Motif 870 (n=111)

Position-wise Probabilities

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uniprot genes site source protein function
A0A0B4J269 None S462 ochoa Melanocyte-stimulating hormone receptor (Melanocortin receptor 1) Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes. {ECO:0000256|ARBA:ARBA00023428}.
A2RU67 FAM234B S75 ochoa Protein FAM234B None
E9PAV3 NACA S1995 ochoa Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC) Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250|UniProtKB:P70670}.
H3BQZ7 HNRNPUL2-BSCL2 S193 ochoa Heterogeneous nuclear ribonucleoprotein U-like protein 2 None
O00411 POLRMT S1184 ochoa DNA-directed RNA polymerase, mitochondrial (MtRPOL) (EC 2.7.7.6) DNA-dependent RNA polymerase catalyzes the transcription of mitochondrial DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:21278163, PubMed:33602924). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA (PubMed:29149603). In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand (PubMed:29149603). Has DNA primase activity (PubMed:18685103, PubMed:33602924). Catalyzes the synthesis of short RNA primers that are necessary for the initiation of lagging-strand DNA synthesis from the origin of light-strand DNA replication (OriL) (PubMed:18685103, PubMed:33602924). {ECO:0000269|PubMed:18685103, ECO:0000269|PubMed:21278163, ECO:0000269|PubMed:29149603, ECO:0000269|PubMed:33602924}.
O15020 SPTBN2 S1964 ochoa Spectrin beta chain, non-erythrocytic 2 (Beta-III spectrin) (Spinocerebellar ataxia 5 protein) Probably plays an important role in neuronal membrane skeleton.
O15240 VGF S65 ochoa Neurosecretory protein VGF [Cleaved into: Neuroendocrine regulatory peptide-1 (NERP-1); Neuroendocrine regulatory peptide-2 (NERP-2); VGF-derived peptide TLQP-21; VGF-derived peptide TLQP-62; Antimicrobial peptide VGF[554-577]] [Neurosecretory protein VGF]: Secreted polyprotein that is packaged and proteolytically processed by prohormone convertases PCSK1 and PCSK2 in a cell-type-specific manner (By similarity). VGF and peptides derived from its processing play many roles in neurogenesis and neuroplasticity associated with learning, memory, depression and chronic pain (By similarity). {ECO:0000250|UniProtKB:P20156, ECO:0000250|UniProtKB:Q0VGU4}.; FUNCTION: [Neuroendocrine regulatory peptide-1]: Plays a role in the control of body fluid homeostasis by regulating vasopressin release. Suppresses presynaptic glutamatergic neurons connected to vasopressin neurons. {ECO:0000250|UniProtKB:P20156}.; FUNCTION: [Neuroendocrine regulatory peptide-2]: Plays a role in the control of body fluid homeostasis by regulating vasopressin release. Activates GABAergic interneurons which are inhibitory neurons of the nervous system and thereby suppresses presynaptic glutamatergic neurons (By similarity). Also stimulates feeding behavior in an orexin-dependent manner in the hypothalamus (By similarity). Functions as a positive regulator for the activation of orexin neurons resulting in elevated gastric acid secretion and gastric emptying (By similarity). {ECO:0000250|UniProtKB:P20156}.; FUNCTION: [VGF-derived peptide TLQP-21]: Secreted multifunctional neuropeptide that binds to different cell receptors and thereby plays multiple physiological roles including modulation of energy expenditure, pain, response to stress, gastric regulation, glucose homeostasis as well as lipolysis (By similarity). Activates the G-protein-coupled receptor C3AR1 via a folding-upon-binding mechanism leading to enhanced lipolysis in adipocytes (By similarity). Interacts with C1QBP receptor in macrophages and microglia causing increased levels of intracellular calcium and hypersensitivity (By similarity). {ECO:0000250|UniProtKB:P20156, ECO:0000250|UniProtKB:Q0VGU4}.; FUNCTION: [VGF-derived peptide TLQP-62]: Plays a role in the regulation of memory formation and depression-related behaviors potentially by influencing synaptic plasticity and neurogenesis. Induces acute and transient activation of the NTRK2/TRKB receptor and subsequent CREB phosphorylation (By similarity). Also induces insulin secretion in insulinoma cells by increasing intracellular calcium mobilization (By similarity). {ECO:0000250|UniProtKB:Q0VGU4}.; FUNCTION: [Antimicrobial peptide VGF[554-577]]: Has bactericidal activity against M.luteus, and antifungal activity against P. Pastoris. {ECO:0000269|PubMed:23250050}.
O15439 ABCC4 S687 ochoa ATP-binding cassette sub-family C member 4 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (MRP/cMOAT-related ABC transporter) (Multi-specific organic anion transporter B) (MOAT-B) (Multidrug resistance-associated protein 4) ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12523936, PubMed:12835412, PubMed:12883481, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12523936, PubMed:12883481, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:17344354, PubMed:18300232). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). {ECO:0000269|PubMed:11106685, ECO:0000269|PubMed:11856762, ECO:0000269|PubMed:12105214, ECO:0000269|PubMed:12523936, ECO:0000269|PubMed:12835412, ECO:0000269|PubMed:12883481, ECO:0000269|PubMed:15364914, ECO:0000269|PubMed:15454390, ECO:0000269|PubMed:16282361, ECO:0000269|PubMed:17344354, ECO:0000269|PubMed:17959747, ECO:0000269|PubMed:18300232, ECO:0000269|PubMed:26721430}.
O43390 HNRNPR S228 ochoa Heterogeneous nuclear ribonucleoprotein R (hnRNP R) Component of ribonucleosomes, which are complexes of at least 20 other different heterogeneous nuclear ribonucleoproteins (hnRNP). hnRNP play an important role in processing of precursor mRNA in the nucleus.
O60496 DOK2 S77 ochoa Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2)) DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity). {ECO:0000250}.
O60832 DKC1 S422 ochoa H/ACA ribonucleoprotein complex subunit DKC1 (EC 5.4.99.-) (CBF5 homolog) (Dyskerin) (Nopp140-associated protein of 57 kDa) (Nucleolar protein NAP57) (Nucleolar protein family A member 4) (snoRNP protein DKC1) [Isoform 1]: Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA (PubMed:25219674, PubMed:32554502). This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1 (PubMed:25219674). Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance (PubMed:19179534, PubMed:25219674). Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme (PubMed:19179534). {ECO:0000269|PubMed:19179534, ECO:0000269|PubMed:25219674, ECO:0000269|PubMed:32554502}.; FUNCTION: [Isoform 3]: Promotes cell to cell and cell to substratum adhesion, increases the cell proliferation rate and leads to cytokeratin hyper-expression. {ECO:0000269|PubMed:21820037}.
O60936 NOL3 S142 ochoa Nucleolar protein 3 (Apoptosis repressor with CARD) (Muscle-enriched cytoplasmic protein) (Myp) (Nucleolar protein of 30 kDa) (Nop30) [Isoform 1]: May be involved in RNA splicing. {ECO:0000269|PubMed:10196175}.; FUNCTION: [Isoform 2]: Functions as an apoptosis repressor that blocks multiple modes of cell death. Inhibits extrinsic apoptotic pathways through two different ways. Firstly by interacting with FAS and FADD upon FAS activation blocking death-inducing signaling complex (DISC) assembly (By similarity). Secondly by interacting with CASP8 in a mitochondria localization- and phosphorylation-dependent manner, limiting the amount of soluble CASP8 available for DISC-mediated activation (By similarity). Inhibits intrinsic apoptotic pathway in response to a wide range of stresses, through its interaction with BAX resulting in BAX inactivation, preventing mitochondrial dysfunction and release of pro-apoptotic factors (PubMed:15004034). Inhibits calcium-mediated cell death by functioning as a cytosolic calcium buffer, dissociating its interaction with CASP8 and maintaining calcium homeostasis (PubMed:15509781). Negatively regulates oxidative stress-induced apoptosis by phosphorylation-dependent suppression of the mitochondria-mediated intrinsic pathway, by blocking CASP2 activation and BAX translocation (By similarity). Negatively regulates hypoxia-induced apoptosis in part by inhibiting the release of cytochrome c from mitochondria in a caspase-independent manner (By similarity). Also inhibits TNF-induced necrosis by preventing TNF-signaling pathway through TNFRSF1A interaction abrogating the recruitment of RIPK1 to complex I (By similarity). Finally through its role as apoptosis repressor, promotes vascular remodeling through inhibition of apoptosis and stimulation of proliferation, in response to hypoxia (By similarity). Inhibits too myoblast differentiation through caspase inhibition (By similarity). {ECO:0000250|UniProtKB:Q62881, ECO:0000250|UniProtKB:Q9D1X0, ECO:0000269|PubMed:15004034, ECO:0000269|PubMed:15509781}.
O75582 RPS6KA5 S368 ochoa Ribosomal protein S6 kinase alpha-5 (S6K-alpha-5) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 5) (Nuclear mitogen- and stress-activated protein kinase 1) (RSK-like protein kinase) (RSKL) Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes (PubMed:11909979, PubMed:12569367, PubMed:12763138, PubMed:18511904, PubMed:9687510, PubMed:9873047). Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin (PubMed:11909979, PubMed:9873047). Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression (PubMed:12628924, PubMed:18511904). In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress (PubMed:12628924). In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential (PubMed:12763138). Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation (PubMed:12569367). Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A (PubMed:15010469). Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN (PubMed:12773393). May also phosphorylate 'Ser-28' of histone H3 (PubMed:12773393). Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14) (PubMed:12773393). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines (By similarity). Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors (By similarity). Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury (By similarity). Phosphorylates TRIM7 at 'Ser-107' in response to growth factor signaling via the MEK/ERK pathway, thereby stimulating its ubiquitin ligase activity (PubMed:25851810). {ECO:0000250|UniProtKB:Q8C050, ECO:0000269|PubMed:11909979, ECO:0000269|PubMed:12569367, ECO:0000269|PubMed:12628924, ECO:0000269|PubMed:12763138, ECO:0000269|PubMed:12773393, ECO:0000269|PubMed:15010469, ECO:0000269|PubMed:18511904, ECO:0000269|PubMed:25851810, ECO:0000269|PubMed:9687510, ECO:0000269|PubMed:9873047}.
O75943 RAD17 S86 ochoa Cell cycle checkpoint protein RAD17 (hRad17) (RF-C/activator 1 homolog) Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage (PubMed:10208430, PubMed:11418864, PubMed:11687627, PubMed:11799063, PubMed:12672690, PubMed:14624239, PubMed:15235112). Has a weak ATPase activity required for binding to chromatin (PubMed:10208430, PubMed:11418864, PubMed:11687627, PubMed:11799063, PubMed:12672690, PubMed:14624239, PubMed:15235112). Participates in the recruitment of the 9-1-1 (RAD1-RAD9-HUS1) complex and RHNO1 onto chromatin, and in CHEK1 activation (PubMed:21659603). Involved in homologous recombination by mediating recruitment of the MRN complex to DNA damage sites (PubMed:24534091). May also serve as a sensor of DNA replication progression (PubMed:12578958, PubMed:14500819, PubMed:15538388). {ECO:0000269|PubMed:10208430, ECO:0000269|PubMed:11418864, ECO:0000269|PubMed:11687627, ECO:0000269|PubMed:11799063, ECO:0000269|PubMed:12578958, ECO:0000269|PubMed:12672690, ECO:0000269|PubMed:14500819, ECO:0000269|PubMed:14624239, ECO:0000269|PubMed:15235112, ECO:0000269|PubMed:15538388, ECO:0000269|PubMed:21659603, ECO:0000269|PubMed:24534091}.
O94804 STK10 S455 ochoa Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase) Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. {ECO:0000269|PubMed:11903060, ECO:0000269|PubMed:12639966, ECO:0000269|PubMed:19255442}.
O94887 FARP2 S886 ochoa FERM, ARHGEF and pleckstrin domain-containing protein 2 (FERM domain-including RhoGEF) (FIR) (FERM, RhoGEF and pleckstrin domain-containing protein 2) (Pleckstrin homology domain-containing family C member 3) (PH domain-containing family C member 3) Functions as a guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity). {ECO:0000250}.
P06744 GPI S176 ochoa Glucose-6-phosphate isomerase (GPI) (EC 5.3.1.9) (Autocrine motility factor) (AMF) (Neuroleukin) (NLK) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI) (Sperm antigen 36) (SA-36) In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis (PubMed:28803808). Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility (PubMed:11437381). Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons (PubMed:11004567, PubMed:3352745). It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion (PubMed:11004567, PubMed:3352745). {ECO:0000269|PubMed:11004567, ECO:0000269|PubMed:11437381, ECO:0000269|PubMed:28803808, ECO:0000269|PubMed:3352745}.
P07437 TUBB S115 ochoa Tubulin beta chain (Tubulin beta-5 chain) Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P08237 PFKM S74 psp ATP-dependent 6-phosphofructokinase, muscle type (ATP-PFK) (PFK-M) (EC 2.7.1.11) (6-phosphofructokinase type A) (Phosphofructo-1-kinase isozyme A) (PFK-A) (Phosphohexokinase) Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
P18583 SON S1570 ochoa Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}.
P19174 PLCG1 Y775 ochoa 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1) Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Plays a role in actin reorganization and cell migration (PubMed:17229814). Guanine nucleotide exchange factor that binds the GTPase DNM1 and catalyzes the dissociation of GDP, allowing a GTP molecule to bind in its place, therefore enhancing DNM1-dependent endocytosis (By similarity). {ECO:0000250|UniProtKB:P10686, ECO:0000269|PubMed:17229814, ECO:0000269|PubMed:37422272}.
P19338 NCL S491 ochoa Nucleolin (Protein C23) Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. {ECO:0000269|PubMed:10393184}.
P21333 FLNA S310 ochoa Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}.
P21796 VDAC1 S240 ochoa Non-selective voltage-gated ion channel VDAC1 (Outer mitochondrial membrane protein porin 1) (Plasmalemmal porin) (Porin 31HL) (Porin 31HM) (Voltage-dependent anion-selective channel protein 1) (VDAC-1) (hVDAC1) Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane (PubMed:10661876, PubMed:11845315, PubMed:18755977, PubMed:30061676, PubMed:8420959). The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis (PubMed:10661876, PubMed:11845315, PubMed:18755977, PubMed:8420959). It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV (PubMed:10661876, PubMed:18755977, PubMed:8420959). The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:18755977, PubMed:8420959). Binds various signaling molecules, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterols cholesterol and oxysterol (PubMed:18755977, PubMed:31015432). In depolarized mitochondria, acts downstream of PRKN and PINK1 to promote mitophagy or prevent apoptosis; polyubiquitination by PRKN promotes mitophagy, while monoubiquitination by PRKN decreases mitochondrial calcium influx which ultimately inhibits apoptosis (PubMed:32047033). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (PubMed:15033708, PubMed:25296756). May mediate ATP export from cells (PubMed:30061676). Part of a complex composed of HSPA9, ITPR1 and VDAC1 that regulates mitochondrial calcium-dependent apoptosis by facilitating calcium transport from the ER lumen to the mitochondria intermembrane space thus providing calcium for the downstream calcium channel MCU that directly releases it into mitochondria matrix (By similarity). Mediates cytochrome c efflux (PubMed:20230784). {ECO:0000250|UniProtKB:Q60932, ECO:0000269|PubMed:10661876, ECO:0000269|PubMed:11845315, ECO:0000269|PubMed:15033708, ECO:0000269|PubMed:18755977, ECO:0000269|PubMed:20230784, ECO:0000269|PubMed:25296756, ECO:0000269|PubMed:30061676, ECO:0000269|PubMed:31015432, ECO:0000269|PubMed:32047033, ECO:0000269|PubMed:8420959}.; FUNCTION: Catalyzes the scrambling of phospholipids across the outer mitochondrial membrane; the mechanism is unrelated to channel activity and is capable of translocating both anionic and zwitterionic phospholipids. {ECO:0000269|PubMed:38065946}.
P23246 SFPQ S283 ochoa|psp Splicing factor, proline- and glutamine-rich (100 kDa DNA-pairing protein) (hPOMp100) (DNA-binding p52/p100 complex, 100 kDa subunit) (Polypyrimidine tract-binding protein-associated-splicing factor) (PSF) (PTB-associated-splicing factor) DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphorylation is proposed to lead to release from THRAP3 allowing binding to pre-mRNA splicing regulatotry elements which represses exon inclusion. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. May be involved in a pre-mRNA coupled splicing and polyadenylation process as component of a snRNP-free complex with SNRPA/U1A. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. SFPQ may be involved in homologous DNA pairing; in vitro, promotes the invasion of ssDNA between a duplex DNA and produces a D-loop formation. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1; in vitro, stimulates dissociation of TOP1 from DNA after cleavage and enhances its jumping between separate DNA helices. The SFPQ-NONO heteromer binds DNA (PubMed:25765647). The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends; in vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. SFPQ is involved in transcriptional regulation. Functions as a transcriptional activator (PubMed:25765647). Transcriptional repression is mediated by an interaction of SFPQ with SIN3A and subsequent recruitment of histone deacetylases (HDACs). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. SFPQ isoform Long binds to the DNA binding domains (DBD) of nuclear hormone receptors, like RXRA and probably THRA, and acts as a transcriptional corepressor in absence of hormone ligands. Binds the DNA sequence 5'-CTGAGTC-3' in the insulin-like growth factor response element (IGFRE) and inhibits IGF1-stimulated transcriptional activity. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation (By similarity). Required for the assembly of nuclear speckles (PubMed:25765647). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000250|UniProtKB:Q8VIJ6, ECO:0000269|PubMed:10847580, ECO:0000269|PubMed:10858305, ECO:0000269|PubMed:10931916, ECO:0000269|PubMed:11259580, ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:11897684, ECO:0000269|PubMed:15590677, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:25765647, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:8045264, ECO:0000269|PubMed:8449401}.
P25205 MCM3 S740 ochoa DNA replication licensing factor MCM3 (EC 3.6.4.12) (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3) (RLF subunit beta) (p102) Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for the entry in S phase and for cell division (Probable). {ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000305|PubMed:35585232}.
P26583 HMGB2 S115 ochoa High mobility group protein B2 (High mobility group protein 2) (HMG-2) Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes. Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:11909973, PubMed:18413230, PubMed:19522541, PubMed:19965638, PubMed:20123072, PubMed:7797075). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a promiscuous immunogenic DNA/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). In the extracellular compartment acts as a chemokine. Promotes proliferation and migration of endothelial cells implicating AGER/RAGE (PubMed:19811285). Has antimicrobial activity in gastrointestinal epithelial tissues (PubMed:23877675). Involved in inflammatory response to antigenic stimulus coupled with pro-inflammatory activity (By similarity). Involved in modulation of neurogenesis probably by regulation of neural stem proliferation (By similarity). Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway (By similarity). {ECO:0000250|UniProtKB:P09429, ECO:0000250|UniProtKB:P30681, ECO:0000269|PubMed:11909973, ECO:0000269|PubMed:18413230, ECO:0000269|PubMed:19522541, ECO:0000269|PubMed:19811285, ECO:0000269|PubMed:19965638, ECO:0000269|PubMed:23877675, ECO:0000269|PubMed:7797075, ECO:0000305|PubMed:20123072}.
P31785 IL2RG S326 ochoa Cytokine receptor common subunit gamma (Interleukin-2 receptor subunit gamma) (IL-2 receptor subunit gamma) (IL-2R subunit gamma) (IL-2RG) (gammaC) (p64) (CD antigen CD132) Common subunit for the receptors for a variety of interleukins. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (PubMed:15123770). {ECO:0000269|PubMed:15123770}.
P45880 VDAC2 S251 ochoa Non-selective voltage-gated ion channel VDAC2 (VDAC-2) (hVDAC2) (Outer mitochondrial membrane protein porin 2) Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane (PubMed:8420959). The channel adopts an open conformation at zero mV and a closed conformation at both positive and negative potentials (PubMed:8420959). There are two populations of channels; the main that functions in a lower open-state conductance with lower ion selectivity, that switch, in a voltage-dependent manner, from the open to a low-conducting 'closed' state and the other that has a normal ion selectivity in the typical high conductance, 'open' state (PubMed:8420959). Binds various lipids, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterols cholesterol and oxysterol (PubMed:31015432). Binding of ceramide promotes the mitochondrial outer membrane permeabilization (MOMP) apoptotic pathway (PubMed:31015432). {ECO:0000269|PubMed:31015432, ECO:0000269|PubMed:8420959}.; FUNCTION: Catalyzes the scrambling of phospholipids across the outer mitochondrial membrane; the mechanism is unrelated to channel activity and is capable of translocating both anionic and zwitterionic phospholipids. {ECO:0000269|PubMed:38065946}.
P51608 MECP2 S65 ochoa Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2) Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). {ECO:0000250|UniProtKB:Q9Z2D6}.
P55011 SLC12A2 S132 ochoa Solute carrier family 12 member 2 (Basolateral Na-K-Cl symporter) (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2) (BSC2) (Na-K-2Cl cotransporter 1) (hNKCC1) Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:33597714, PubMed:35585053, PubMed:36239040, PubMed:36306358, PubMed:7629105). Plays a vital role in the regulation of ionic balance and cell volume (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:7629105). {ECO:0000269|PubMed:16669787, ECO:0000269|PubMed:32081947, ECO:0000269|PubMed:32294086, ECO:0000269|PubMed:33597714, ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36239040, ECO:0000269|PubMed:36306358, ECO:0000269|PubMed:7629105}.
P57103 SLC8A3 S382 ochoa Sodium/calcium exchanger 3 (Na(+)/Ca(2+)-exchange protein 3) (Solute carrier family 8 member 3) Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells, both in muscle and in brain. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A3 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In neurons, contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory (By similarity). Required for normal oligodendrocyte differentiation and for normal myelination (PubMed:21959935). Mediates Ca(2+) efflux from mitochondria and contributes to mitochondrial Ca(2+) ion homeostasis (By similarity). {ECO:0000250|UniProtKB:S4R2P9, ECO:0000269|PubMed:21959935}.
P60484 PTEN S380 psp Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.16) (EC 3.1.3.48) (EC 3.1.3.67) (Inositol polyphosphate 3-phosphatase) (EC 3.1.3.-) (Mutated in multiple advanced cancers 1) (Phosphatase and tensin homolog) Dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins (PubMed:9187108, PubMed:9256433, PubMed:9616126). Also functions as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring of PtdIns(3,4,5)P3/phosphatidylinositol 3,4,5-trisphosphate, PtdIns(3,4)P2/phosphatidylinositol 3,4-diphosphate and PtdIns3P/phosphatidylinositol 3-phosphate with a preference for PtdIns(3,4,5)P3 (PubMed:16824732, PubMed:26504226, PubMed:9593664, PubMed:9811831). Furthermore, this enzyme can also act as a cytosolic inositol 3-phosphatase acting on Ins(1,3,4,5,6)P5/inositol 1,3,4,5,6 pentakisphosphate and possibly Ins(1,3,4,5)P4/1D-myo-inositol 1,3,4,5-tetrakisphosphate (PubMed:11418101, PubMed:15979280). Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (PubMed:31492966, PubMed:37279284). The unphosphorylated form cooperates with MAGI2 to suppress AKT1 activation (PubMed:11707428). In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement (PubMed:22279049). Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation (PubMed:22279049). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces PTEN phosphorylation which changes its binding preference from the p85 regulatory subunit of the PI3K kinase complex to DLC1 and results in translocation of the PTEN-DLC1 complex to the posterior of migrating cells to promote RHOA activation (PubMed:26166433). Meanwhile, TNS3 switches binding preference from DLC1 to p85 and the TNS3-p85 complex translocates to the leading edge of migrating cells to activate RAC1 activation (PubMed:26166433). Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Involved in the regulation of synaptic function in excitatory hippocampal synapses. Recruited to the postsynaptic membrane upon NMDA receptor activation, is required for the modulation of synaptic activity during plasticity. Enhancement of lipid phosphatase activity is able to drive depression of AMPA receptor-mediated synaptic responses, activity required for NMDA receptor-dependent long-term depression (LTD) (By similarity). May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability (PubMed:10468583, PubMed:18716620). {ECO:0000250|UniProtKB:O08586, ECO:0000250|UniProtKB:O54857, ECO:0000269|PubMed:10468583, ECO:0000269|PubMed:11418101, ECO:0000269|PubMed:11707428, ECO:0000269|PubMed:15979280, ECO:0000269|PubMed:16824732, ECO:0000269|PubMed:18716620, ECO:0000269|PubMed:22279049, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26504226, ECO:0000269|PubMed:31492966, ECO:0000269|PubMed:37279284, ECO:0000269|PubMed:9187108, ECO:0000269|PubMed:9256433, ECO:0000269|PubMed:9593664, ECO:0000269|PubMed:9616126, ECO:0000269|PubMed:9811831}.; FUNCTION: [Isoform alpha]: Functional kinase, like isoform 1 it antagonizes the PI3K-AKT/PKB signaling pathway. Plays a role in mitochondrial energetic metabolism by promoting COX activity and ATP production, via collaboration with isoform 1 in increasing protein levels of PINK1. {ECO:0000269|PubMed:23744781}.
P60709 ACTB S300 ochoa Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (PubMed:39321809, PubMed:38609661). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:Q6QAQ1, ECO:0000269|PubMed:25255767, ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}.
P62910 RPL32 S105 ochoa Large ribosomal subunit protein eL32 (60S ribosomal protein L32) Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}.
P63261 ACTG1 S300 ochoa Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage (By similarity). {ECO:0000250|UniProtKB:P63260, ECO:0000305|PubMed:29581253}.
P68371 TUBB4B S115 ochoa Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain) Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P78527 PRKDC S2932 ochoa DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250|UniProtKB:P97313, ECO:0000269|PubMed:10026262, ECO:0000269|PubMed:10467406, ECO:0000269|PubMed:11889123, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12509254, ECO:0000269|PubMed:12649176, ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:14612514, ECO:0000269|PubMed:14627815, ECO:0000269|PubMed:14704337, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:15262962, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:1597196, ECO:0000269|PubMed:16046194, ECO:0000269|PubMed:16397295, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:2247066, ECO:0000269|PubMed:2507541, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30247612, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33854234, ECO:0000269|PubMed:34352203, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:8407951, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9362500, ECO:0000269|PubMed:9363941, ECO:0000269|PubMed:9679063}.
P98171 ARHGAP4 S216 ochoa Rho GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (Rho-type GTPase-activating protein 4) (p115) Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells.
Q00536 CDK16 S65 ochoa|psp Cyclin-dependent kinase 16 (EC 2.7.11.22) (Cell division protein kinase 16) (PCTAIRE-motif protein kinase 1) (Serine/threonine-protein kinase PCTAIRE-1) Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro). {ECO:0000250, ECO:0000269|PubMed:22184064, ECO:0000269|PubMed:22796189, ECO:0000269|PubMed:22798068}.
Q01538 MYT1 S108 ochoa Myelin transcription factor 1 (MyT1) (Myelin transcription factor I) (MyTI) (PLPB1) (Proteolipid protein-binding protein) Binds to the promoter region of genes encoding proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendroglia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription. {ECO:0000269|PubMed:14962745}.
Q02556 IRF8 S232 ochoa Interferon regulatory factor 8 (IRF-8) (Interferon consensus sequence-binding protein) (H-ICSBP) (ICSBP) Transcription factor that specifically binds to the upstream regulatory region of type I interferon (IFN) and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) (PubMed:25122610). Can both act as a transcriptional activator or repressor (By similarity). Plays a negative regulatory role in cells of the immune system (By similarity). Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes (By similarity). Required for the development of plasmacytoid dendritic cells (pDCs), which produce most of the type I IFN in response to viral infection (By similarity). Positively regulates macroautophagy in dendritic cells (PubMed:29434592). Acts as a transcriptional repressor of osteoclast differentiation factors such as NFATC1 and EEIG1 (By similarity). {ECO:0000250|UniProtKB:P23611, ECO:0000269|PubMed:25122610, ECO:0000269|PubMed:29434592}.
Q04837 SSBP1 S70 ochoa Single-stranded DNA-binding protein, mitochondrial (Mt-SSB) (MtSSB) (PWP1-interacting protein 17) Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA) (PubMed:21953457, PubMed:23290262, PubMed:31550240). In vitro, required to maintain the copy number of mitochondrial DNA (mtDNA) and plays a crucial role during mtDNA replication by stimulating the activity of the replisome components POLG and TWNK at the replication fork (PubMed:12975372, PubMed:15167897, PubMed:21953457, PubMed:26446790, PubMed:31550240). Promotes the activity of the gamma complex polymerase POLG, largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate POLG activity (PubMed:21953457, PubMed:26446790, PubMed:31550240). In addition it is able to promote the 5'-3' unwinding activity of the mtDNA helicase TWNK (PubMed:12975372). May also function in mtDNA repair (PubMed:23290262). {ECO:0000269|PubMed:12975372, ECO:0000269|PubMed:15167897, ECO:0000269|PubMed:21953457, ECO:0000269|PubMed:23290262, ECO:0000269|PubMed:26446790, ECO:0000269|PubMed:31550240}.
Q09666 AHNAK S110 ochoa Neuroblast differentiation-associated protein AHNAK (Desmoyokin) May be required for neuronal cell differentiation.
Q13509 TUBB3 S115 ochoa Tubulin beta-3 chain (Tubulin beta-4 chain) (Tubulin beta-III) Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:34996871, PubMed:38305685, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:34996871, PubMed:38305685, PubMed:38609661). Below the cap, alpha-beta tubulin heterodimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). TUBB3 plays a critical role in proper axon guidance and maintenance (PubMed:20074521). Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Plays a role in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). {ECO:0000269|PubMed:20074521, ECO:0000269|PubMed:28483977, ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}.
Q13885 TUBB2A S115 ochoa Tubulin beta-2A chain (Tubulin beta class IIa) Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q14157 UBAP2L S254 ochoa Ubiquitin-associated protein 2-like (Protein NICE-4) (RNA polymerase II degradation factor UBAP2L) Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs) (By similarity). Is a regulator of stress granule assembly, required for their efficient formation (PubMed:29395067, PubMed:35977029). Required for proper brain development and neocortex lamination (By similarity). {ECO:0000250|UniProtKB:Q80X50, ECO:0000269|PubMed:29395067, ECO:0000269|PubMed:35633597}.
Q1KMD3 HNRNPUL2 S193 ochoa Heterogeneous nuclear ribonucleoprotein U-like protein 2 (Scaffold-attachment factor A2) (SAF-A2) None
Q5JTC6 AMER1 S42 ochoa APC membrane recruitment protein 1 (Amer1) (Protein FAM123B) (Wilms tumor gene on the X chromosome protein) Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development. {ECO:0000269|PubMed:17510365, ECO:0000269|PubMed:17925383, ECO:0000269|PubMed:19416806, ECO:0000269|PubMed:21304492, ECO:0000269|PubMed:21498506}.
Q6NWY9 PRPF40B S847 ochoa Pre-mRNA-processing factor 40 homolog B (Huntingtin yeast partner C) (Huntingtin-interacting protein C) May be involved in pre-mRNA splicing. {ECO:0000269|PubMed:9700202}.
Q6PJG2 MIDEAS S709 ochoa Mitotic deacetylase-associated SANT domain protein (ELM2 and SANT domain-containing protein 1) None
Q7L4E1 MIGA2 S224 ochoa Mitoguardin 2 (Protein FAM73B) Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD. {ECO:0000269|PubMed:26711011}.
Q7Z3K3 POGZ S721 ochoa Pogo transposable element with ZNF domain (Suppressor of hairy wing homolog 5) (Zinc finger protein 280E) (Zinc finger protein 635) Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms (PubMed:20562864). Promotes the repair of DNA double-strand breaks through the homologous recombination pathway (PubMed:26721387). {ECO:0000269|PubMed:20562864, ECO:0000269|PubMed:26721387}.
Q7Z434 MAVS S409 ochoa Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA) Adapter required for innate immune defense against viruses (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:21170385, PubMed:23087404, PubMed:27992402, PubMed:33139700, PubMed:37582970). Acts downstream of DHX33, RIGI and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFNB and RANTES (CCL5) (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:20628368, PubMed:21170385, PubMed:23087404, PubMed:25636800, PubMed:27736772, PubMed:33110251). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state (PubMed:20451243). Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response (PubMed:20451243). May activate the same pathways following detection of extracellular dsRNA by TLR3 (PubMed:16153868). May protect cells from apoptosis (PubMed:16125763). Involved in NLRP3 inflammasome activation by mediating NLRP3 recruitment to mitochondria (PubMed:23582325). {ECO:0000269|PubMed:16125763, ECO:0000269|PubMed:16127453, ECO:0000269|PubMed:16153868, ECO:0000269|PubMed:16177806, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20451243, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:23087404, ECO:0000269|PubMed:23582325, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:27992402, ECO:0000269|PubMed:33110251, ECO:0000269|PubMed:33139700, ECO:0000269|PubMed:37582970}.
Q86WR7 PROSER2 S311 ochoa Proline and serine-rich protein 2 None
Q8IV36 HID1 S616 ochoa Protein HID1 (Down-regulated in multiple cancers 1) (HID1 domain-containing protein) (Protein hid-1 homolog) May play an important role in the development of cancers in a broad range of tissues. {ECO:0000269|PubMed:11281419}.
Q8IVH2 FOXP4 S52 ochoa Forkhead box protein P4 (Fork head-related protein-like A) Transcriptional repressor that represses lung-specific expression. {ECO:0000250}.
Q8IXU6 SLC35F2 S24 ochoa Solute carrier family 35 member F2 Putative solute transporter. {ECO:0000305}.
Q8N1F7 NUP93 S168 ochoa Nuclear pore complex protein Nup93 (93 kDa nucleoporin) (Nucleoporin Nup93) Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling (PubMed:26878725). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:15703211, ECO:0000269|PubMed:26878725, ECO:0000269|PubMed:9348540}.
Q8N2F6 ARMC10 S54 ochoa Armadillo repeat-containing protein 10 (Splicing variant involved in hepatocarcinogenesis protein) May play a role in cell survival and cell growth. May suppress the transcriptional activity of p53/TP53. {ECO:0000269|PubMed:12839973, ECO:0000269|PubMed:17904127}.
Q8N5U6 RNF10 S128 ochoa E3 ubiquitin-protein ligase RNF10 (EC 2.3.2.27) (RING finger protein 10) E3 ubiquitin-protein ligase that catalyzes monoubiquitination of 40S ribosomal proteins RPS2/us5 and RPS3/us3 in response to ribosome stalling (PubMed:34348161, PubMed:34469731). Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC): RNF10 acts by mediating monoubiquitination of RPS2/us5 and RPS3/us3, promoting their degradation by the proteasome (PubMed:34348161, PubMed:34469731). Also promotes ubiquitination of 40S ribosomal proteins in response to ribosome stalling during translation elongation (PubMed:34348161). The action of RNF10 in iRQC is counteracted by USP10 (PubMed:34469731). May also act as a transcriptional factor involved in the regulation of MAG (Myelin-associated glycoprotein) expression (By similarity). Acts as a regulator of Schwann cell differentiation and myelination (By similarity). {ECO:0000250|UniProtKB:Q5XI59, ECO:0000269|PubMed:34348161, ECO:0000269|PubMed:34469731}.
Q8NFQ8 TOR1AIP2 S167 ochoa Torsin-1A-interacting protein 2 (Lumenal domain-like LAP1) Required for endoplasmic reticulum integrity. Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope as well as induces TOR1A, TOR1B and TOR3A ATPase activity. {ECO:0000269|PubMed:19339278, ECO:0000269|PubMed:23569223, ECO:0000269|PubMed:24275647}.
Q8WUX9 CHMP7 S431 ochoa Charged multivesicular body protein 7 (Chromatin-modifying protein 7) ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope (NE) during late anaphase (PubMed:26040712). Together with SPAST, the ESCRT-III complex promotes NE sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712, PubMed:28242692). Recruited to the reforming NE during anaphase by LEMD2 (PubMed:28242692). Plays a role in the endosomal sorting pathway (PubMed:16856878). {ECO:0000269|PubMed:16856878, ECO:0000269|PubMed:26040712, ECO:0000269|PubMed:28242692}.
Q92599 SEPTIN8 S20 ochoa Septin-8 Filament-forming cytoskeletal GTPase (By similarity). May play a role in platelet secretion (PubMed:15116257). Seems to participate in the process of SNARE complex formation in synaptic vesicles (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:B0BNF1, ECO:0000269|PubMed:15116257}.; FUNCTION: [Isoform 4]: Stabilizes BACE1 protein levels and promotes the sorting and accumulation of BACE1 to the recycling or endosomal compartments, modulating the beta-amyloidogenic processing of APP. {ECO:0000269|PubMed:27084579}.
Q92797 SYMPK S1222 ochoa Symplekin Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity. {ECO:0000269|PubMed:16230528, ECO:0000269|PubMed:20861839}.
Q969W9 PMEPA1 S233 ochoa Protein TMEPAI (Prostate transmembrane protein androgen induced 1) (Solid tumor-associated 1 protein) (Transmembrane prostate androgen-induced protein) Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal (PubMed:20129061, PubMed:24627487). Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4 (PubMed:18703514). {ECO:0000269|PubMed:18703514, ECO:0000269|PubMed:20129061, ECO:0000269|PubMed:24627487}.
Q96DT7 ZBTB10 S80 ochoa Zinc finger and BTB domain-containing protein 10 (Zinc finger protein RIN ZF) May be involved in transcriptional regulation.
Q96G28 CFAP36 S201 ochoa Cilia- and flagella-associated protein 36 (Coiled-coil domain-containing protein 104) May act as an effector for ARL3.
Q96GX5 MASTL S631 ochoa Serine/threonine-protein kinase greatwall (GW) (GWL) (hGWL) (EC 2.7.11.1) (Microtubule-associated serine/threonine-protein kinase-like) (MAST-L) Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance (PubMed:19680222). Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively (PubMed:38123684). ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high (PubMed:20818157). Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation. {ECO:0000269|PubMed:12890928, ECO:0000269|PubMed:19680222, ECO:0000269|PubMed:19793917, ECO:0000269|PubMed:20538976, ECO:0000269|PubMed:20818157, ECO:0000269|PubMed:38123684}.
Q96T37 RBM15 S175 ochoa RNA-binding protein 15 (One-twenty two protein 1) (RNA-binding motif protein 15) RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (By similarity). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation (By similarity). Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation (PubMed:26575292). Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen (By similarity). Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL (By similarity). May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing (PubMed:17001072, PubMed:19786495). High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing (PubMed:17001072, PubMed:19786495). May be implicated in HOX gene regulation (PubMed:11344311). {ECO:0000250|UniProtKB:Q0VBL3, ECO:0000269|PubMed:17001072, ECO:0000269|PubMed:19786495, ECO:0000269|PubMed:26575292, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:11344311}.
Q96TC7 RMDN3 S225 ochoa Regulator of microtubule dynamics protein 3 (RMD-3) (hRMD-3) (Cerebral protein 10) (Protein FAM82A2) (Protein FAM82C) (Protein tyrosine phosphatase-interacting protein 51) (TCPTP-interacting protein 51) Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis. {ECO:0000269|PubMed:16820967, ECO:0000269|PubMed:22131369}.
Q99442 SEC62 S356 ochoa Translocation protein SEC62 (Translocation protein 1) (TP-1) (hTP-1) Mediates post-translational transport of precursor polypeptides across endoplasmic reticulum (ER). Proposed to act as a targeting receptor for small presecretory proteins containing short and apolar signal peptides. Targets and properly positions newly synthesized presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen. {ECO:0000269|PubMed:22375059, ECO:0000269|PubMed:29719251}.
Q9BVA1 TUBB2B S115 ochoa Tubulin beta-2B chain Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:23001566, PubMed:26732629, PubMed:28013290). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910). {ECO:0000269|PubMed:19465910, ECO:0000269|PubMed:23001566, ECO:0000269|PubMed:26732629, ECO:0000269|PubMed:28013290}.
Q9BVS4 RIOK2 S350 ochoa|psp Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (RIO kinase 2) Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA (PubMed:19564402). Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function (PubMed:21880710). {ECO:0000269|PubMed:16037817, ECO:0000269|PubMed:19564402, ECO:0000269|PubMed:21880710}.
Q9BW71 HIRIP3 S300 ochoa HIRA-interacting protein 3 Histone chaperone that carries a H2A-H2B histone complex and facilitates its deposition onto chromatin. {ECO:0000269|PubMed:38334665, ECO:0000269|PubMed:9710638}.
Q9BXS6 NUSAP1 S149 ochoa Nucleolar and spindle-associated protein 1 (NuSAP) Microtubule-associated protein with the capacity to bundle and stabilize microtubules (By similarity). May associate with chromosomes and promote the organization of mitotic spindle microtubules around them. {ECO:0000250, ECO:0000269|PubMed:12963707}.
Q9C0B0 UNK S411 ochoa RING finger protein unkempt homolog (Zinc finger CCCH domain-containing protein 5) Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280). {ECO:0000269|PubMed:25737280}.
Q9C0C2 TNKS1BP1 S936 ochoa 182 kDa tankyrase-1-binding protein None
Q9H0W5 CCDC8 S401 ochoa Coiled-coil domain-containing protein 8 Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695, PubMed:24793696). Required for localization of CUL7 to the centrosome (PubMed:24793695). {ECO:0000269|PubMed:24793695, ECO:0000269|PubMed:24793696}.
Q9H0W8 SMG9 S53 ochoa Nonsense-mediated mRNA decay factor SMG9 Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:19417104). Is recruited by release factors to stalled ribosomes together with SMG1 and SMG8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between SMG1 and SMG8 (PubMed:19417104). Plays a role in brain, heart, and eye development (By similarity). {ECO:0000250|UniProtKB:Q9DB90, ECO:0000269|PubMed:19417104}.
Q9H773 DCTPP1 S150 ochoa dCTP pyrophosphatase 1 (EC 3.6.1.12) (Deoxycytidine-triphosphatase 1) (dCTPase 1) (RS21C6) (XTP3-transactivated gene A protein) Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism. {ECO:0000269|PubMed:24467396}.
Q9NSI6 BRWD1 S2011 ochoa Bromodomain and WD repeat-containing protein 1 (WD repeat-containing protein 9) May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000250, ECO:0000269|PubMed:21834987}.
Q9NUQ6 SPATS2L S526 ochoa SPATS2-like protein (DNA polymerase-transactivated protein 6) (Stress granule and nucleolar protein) (SGNP) None
Q9NX61 TMEM161A S69 ochoa Transmembrane protein 161A (Adaptive response to oxidative stress protein 29) (AROS-29) May play a role in protection against oxidative stress. Overexpression leads to reduced levels of oxidant-induced DNA damage and apoptosis. {ECO:0000269|PubMed:16551573}.
Q9UGI8 TES S140 ochoa Testin (TESS) Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. Inhibits tumor cell growth. {ECO:0000269|PubMed:11420696, ECO:0000269|PubMed:12571287, ECO:0000269|PubMed:12695497}.
Q9UID3 VPS51 S44 ochoa Vacuolar protein sorting-associated protein 51 homolog (Another new gene 2 protein) (Protein fat-free homolog) Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN (PubMed:20685960). Acts as a component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane (PubMed:25799061). {ECO:0000269|PubMed:20685960, ECO:0000269|PubMed:25799061}.
Q9UJM3 ERRFI1 S391 ochoa ERBB receptor feedback inhibitor 1 (Mitogen-inducible gene 6 protein) (MIG-6) Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity). {ECO:0000250}.
Q9UKN1 MUC12 S5442 ochoa Mucin-12 (MUC-12) (Mucin-11) (MUC-11) Involved in epithelial cell protection, adhesion modulation, and signaling. May be involved in epithelial cell growth regulation. Stimulated by both cytokine TNF-alpha and TGF-beta in intestinal epithelium. {ECO:0000269|PubMed:17058067}.
Q9ULU4 ZMYND8 S533 ochoa MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8) Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) (PubMed:26655721, PubMed:27477906, PubMed:31965980, PubMed:36064715). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac (PubMed:27477906). May also act as a transcriptional corepressor for KDM5C and EZH2 (PubMed:33323928). Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309, PubMed:27732854, PubMed:30134174). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (PubMed:26655721, PubMed:30134174). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression (PubMed:26655721). Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform (PubMed:30134174, PubMed:35916866, PubMed:36064715). Suppresses breast cancer, and prostate cancer cell invasion and metastasis (PubMed:27477906, PubMed:31965980, PubMed:33323928). {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:26655721, ECO:0000269|PubMed:27477906, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:31965980, ECO:0000269|PubMed:33323928, ECO:0000269|PubMed:35916866, ECO:0000269|PubMed:36064715}.
Q9ULU4 ZMYND8 S1119 ochoa MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8) Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) (PubMed:26655721, PubMed:27477906, PubMed:31965980, PubMed:36064715). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac (PubMed:27477906). May also act as a transcriptional corepressor for KDM5C and EZH2 (PubMed:33323928). Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309, PubMed:27732854, PubMed:30134174). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (PubMed:26655721, PubMed:30134174). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression (PubMed:26655721). Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform (PubMed:30134174, PubMed:35916866, PubMed:36064715). Suppresses breast cancer, and prostate cancer cell invasion and metastasis (PubMed:27477906, PubMed:31965980, PubMed:33323928). {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:26655721, ECO:0000269|PubMed:27477906, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:31965980, ECO:0000269|PubMed:33323928, ECO:0000269|PubMed:35916866, ECO:0000269|PubMed:36064715}.
Q9UMS6 SYNPO2 S274 ochoa Synaptopodin-2 (Genethonin-2) (Myopodin) Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}.
Q9UNF1 MAGED2 S84 ochoa Melanoma-associated antigen D2 (11B6) (Breast cancer-associated gene 1 protein) (BCG-1) (Hepatocellular carcinoma-associated protein JCL-1) (MAGE-D2 antigen) Regulates the expression, localization to the plasma membrane and function of the sodium chloride cotransporters SLC12A1 and SLC12A3, two key components of salt reabsorption in the distal renal tubule. {ECO:0000269|PubMed:27120771}.
Q9Y285 FARSA S198 ochoa Phenylalanine--tRNA ligase alpha subunit (EC 6.1.1.20) (CML33) (Phenylalanyl-tRNA synthetase alpha subunit) (PheRS) None
Q9Y2J4 AMOTL2 S549 ochoa Angiomotin-like protein 2 (Leman coiled-coil protein) (LCCP) Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Plays a role in coupling actin fibers to cell junctions in endothelial cells and is therefore required for correct endothelial cell morphology via facilitating transcellular transmission of mechanical force resulting in endothelial cell elongation (By similarity). Required for the anchoring of radial actin fibers to CDH1 junction complexes at the cell membrane which facilitates organization of radial actin fiber structure and cellular response to contractile forces (PubMed:28842668). This contributes to maintenance of cell area, size, shape, epithelial sheet organization and trophectoderm cell properties that facilitate blastocyst zona hatching (PubMed:28842668). Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. Activates the Hippo signaling pathway in response to cell contact inhibition via interaction with and ubiquitination by Crumbs complex-bound WWP1 (PubMed:34404733). Ubiquitinated AMOTL2 then interacts with LATS2 which in turn phosphorylates YAP1, excluding it from the nucleus and localizing it to the cytoplasm and tight junctions, therefore ultimately repressing YAP1-driven transcription of target genes (PubMed:17293535, PubMed:21205866, PubMed:26598551). Acts to inhibit WWTR1/TAZ transcriptional coactivator activity via sequestering WWTR1/TAZ in the cytoplasm and at tight junctions (PubMed:23911299). Regulates the size and protein composition of the podosome cortex and core at myofibril neuromuscular junctions (PubMed:23525008). Selectively promotes FGF-induced MAPK activation through SRC (PubMed:17293535). May play a role in the polarity, proliferation and migration of endothelial cells. {ECO:0000250|UniProtKB:Q8K371, ECO:0000269|PubMed:17293535, ECO:0000269|PubMed:21205866, ECO:0000269|PubMed:21937427, ECO:0000269|PubMed:22362771, ECO:0000269|PubMed:23525008, ECO:0000269|PubMed:23911299, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:28842668, ECO:0000269|PubMed:34404733}.
Q9Y6R9 CCDC61 S469 ochoa Centrosomal protein CCDC61 (Coiled-coil domain-containing protein 61) (VFL3 homolog) Microtubule-binding centrosomal protein required for centriole cohesion, independently of the centrosome-associated protein/CEP250 and rootletin/CROCC linker (PubMed:31789463). In interphase, required for anchoring microtubule at the mother centriole subdistal appendages and for centrosome positioning (PubMed:31789463). During mitosis, may be involved in spindle assembly and chromatin alignment by regulating the organization of spindle microtubules into a symmetrical structure (PubMed:30354798). Has been proposed to play a role in CEP170 recruitment to centrosomes (PubMed:30354798). However, this function could not be confirmed (PubMed:31789463). Plays a non-essential role in ciliogenesis (PubMed:31789463, PubMed:32375023). {ECO:0000269|PubMed:30354798, ECO:0000269|PubMed:31789463, ECO:0000269|PubMed:32375023}.
P00558 PGK1 S393 Sugiyama Phosphoglycerate kinase 1 (EC 2.7.11.1) (EC 2.7.2.3) (Cell migration-inducing gene 10 protein) (Primer recognition protein 2) (PRP 2) Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate (PubMed:30323285, PubMed:7391028). Both L- and D- forms of purine and pyrimidine nucleotides can be used as substrates, but the activity is much lower on pyrimidines (PubMed:18463139). In addition to its role as a glycolytic enzyme, it seems that PGK1 acts as a polymerase alpha cofactor protein (primer recognition protein) (PubMed:2324090). Acts as a protein kinase when localized to the mitochondrion where it phosphorylates pyruvate dehydrogenase kinase PDK1 to inhibit pyruvate dehydrogenase complex activity and suppress the formation of acetyl-coenzyme A from pyruvate, and consequently inhibit oxidative phosphorylation and promote glycolysis (PubMed:26942675, PubMed:36849569). May play a role in sperm motility (PubMed:26677959). {ECO:0000269|PubMed:18463139, ECO:0000269|PubMed:2324090, ECO:0000269|PubMed:26677959, ECO:0000269|PubMed:26942675, ECO:0000269|PubMed:30323285, ECO:0000269|PubMed:36849569, ECO:0000269|PubMed:7391028}.
P07205 PGK2 S393 Sugiyama Phosphoglycerate kinase 2 (EC 2.7.2.3) (Phosphoglycerate kinase, testis specific) Essential for sperm motility and male fertility (PubMed:26677959). Not required for the completion of spermatogenesis (By similarity). {ECO:0000250|UniProtKB:P09041, ECO:0000269|PubMed:26677959}.
P27797 CALR S52 Sugiyama Calreticulin (CRP55) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP) (grp60) Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (PubMed:7876246). Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (PubMed:11149926). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity). {ECO:0000250|UniProtKB:P28491, ECO:0000250|UniProtKB:Q8K3H7, ECO:0000269|PubMed:11149926, ECO:0000269|PubMed:7876246}.
Q9HDC9 APMAP S188 Sugiyama Adipocyte plasma membrane-associated protein (Protein BSCv) Exhibits strong arylesterase activity with beta-naphthyl acetate and phenyl acetate. May play a role in adipocyte differentiation. {ECO:0000269|PubMed:18513186}.
Q14694 USP10 S265 Sugiyama Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.4.19.12) (Deubiquitinating enzyme 10) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10) Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, RPS2/us5, RPS3/us3, RPS10/eS10, BECN1, SNX3 and CFTR (PubMed:11439350, PubMed:18632802, PubMed:31981475). Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53 (PubMed:20096447). Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response (PubMed:20096447). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes (PubMed:21962518). In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13 (PubMed:21962518). Does not deubiquitinate MDM2 (PubMed:20096447). Plays a key role in 40S ribosome subunit recycling when a ribosome has stalled during translation: acts both by inhibiting formation of stress granules, which store stalled translation pre-initiation complexes, and mediating deubiquitination of 40S ribosome subunits (PubMed:27022092, PubMed:31981475, PubMed:34348161, PubMed:34469731). Acts as a negative regulator of stress granules formation by lowering G3BP1 and G3BP2 valence, thereby preventing G3BP1 and G3BP2 ability to undergo liquid-liquid phase separation (LLPS) and assembly of stress granules (PubMed:11439350, PubMed:27022092, PubMed:32302570). Promotes 40S ribosome subunit recycling following ribosome dissociation in response to ribosome stalling by mediating deubiquitination of 40S ribosomal proteins RPS2/us5, RPS3/us3 and RPS10/eS10, thereby preventing their degradation by the proteasome (PubMed:31981475, PubMed:34348161, PubMed:34469731). Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC): USP10 acts by removing monoubiquitination of RPS2/us5 and RPS3/us3, promoting 40S ribosomal subunit recycling (PubMed:34469731). Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling (PubMed:19398555). Involved in a TANK-dependent negative feedback response to attenuate NF-kappa-B activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Deubiquitinates TBX21 leading to its stabilization (PubMed:24845384). Plays a negative role in the RLR signaling pathway upon RNA virus infection by blocking the RIGI-mediated MAVS activation. Mechanistically, removes the unanchored 'Lys-63'-linked polyubiquitin chains of MAVS to inhibit its aggregation, essential for its activation (PubMed:37582970). {ECO:0000269|PubMed:11439350, ECO:0000269|PubMed:18632802, ECO:0000269|PubMed:19398555, ECO:0000269|PubMed:20096447, ECO:0000269|PubMed:21962518, ECO:0000269|PubMed:24845384, ECO:0000269|PubMed:25861989, ECO:0000269|PubMed:27022092, ECO:0000269|PubMed:31981475, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:34348161, ECO:0000269|PubMed:34469731, ECO:0000269|PubMed:37582970}.
Q13765 NACA S132 Sugiyama Nascent polypeptide-associated complex subunit alpha (NAC-alpha) (Alpha-NAC) (allergen Hom s 2) Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters. {ECO:0000269|PubMed:10982809, ECO:0000269|PubMed:15784678, ECO:0000269|PubMed:9877153}.
P60174 TPI1 S97 Sugiyama Triosephosphate isomerase (TIM) (EC 5.3.1.1) (Methylglyoxal synthase) (EC 4.2.3.3) (Triose-phosphate isomerase) Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. {ECO:0000269|PubMed:18562316}.; FUNCTION: It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids. {ECO:0000250|UniProtKB:P00939}.
P09960 LTA4H S236 Sugiyama Leukotriene A-4 hydrolase (LTA-4 hydrolase) (EC 3.3.2.6) (Leukotriene A(4) hydrolase) (Tripeptide aminopeptidase LTA4H) (EC 3.4.11.4) Bifunctional zinc metalloenzyme that comprises both epoxide hydrolase (EH) and aminopeptidase activities. Acts as an epoxide hydrolase to catalyze the conversion of LTA4 to the pro-inflammatory mediator leukotriene B4 (LTB4) (PubMed:11917124, PubMed:12207002, PubMed:15078870, PubMed:18804029, PubMed:1897988, PubMed:1975494, PubMed:2244921). Also has aminopeptidase activity, with high affinity for N-terminal arginines of various synthetic tripeptides (PubMed:18804029, PubMed:20813919). In addition to its pro-inflammatory EH activity, may also counteract inflammation by its aminopeptidase activity, which inactivates by cleavage another neutrophil attractant, the tripeptide Pro-Gly-Pro (PGP), a bioactive fragment of collagen generated by the action of matrix metalloproteinase-9 (MMP9) and prolylendopeptidase (PREPL) (PubMed:20813919, PubMed:24591641). Involved also in the biosynthesis of resolvin E1 and 18S-resolvin E1 from eicosapentaenoic acid, two lipid mediators that show potent anti-inflammatory and pro-resolving actions (PubMed:21206090). {ECO:0000269|PubMed:11917124, ECO:0000269|PubMed:12207002, ECO:0000269|PubMed:15078870, ECO:0000269|PubMed:18804029, ECO:0000269|PubMed:1897988, ECO:0000269|PubMed:1975494, ECO:0000269|PubMed:20813919, ECO:0000269|PubMed:21206090, ECO:0000269|PubMed:2244921, ECO:0000269|PubMed:24591641}.
P00505 GOT2 S118 Sugiyama Aspartate aminotransferase, mitochondrial (mAspAT) (EC 2.6.1.1) (EC 2.6.1.7) (Fatty acid-binding protein) (FABP-1) (Glutamate oxaloacetate transaminase 2) (Kynurenine aminotransferase 4) (Kynurenine aminotransferase IV) (Kynurenine--oxoglutarate transaminase 4) (Kynurenine--oxoglutarate transaminase IV) (Plasma membrane-associated fatty acid-binding protein) (FABPpm) (Transaminase A) Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism. Facilitates cellular uptake of long-chain free fatty acids. {ECO:0000269|PubMed:31422819, ECO:0000269|PubMed:9537447}.
P22102 GART S106 Sugiyama Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (Glycinamide ribonucleotide synthetase) (GARS) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIR synthase) (AIRS) (Phosphoribosyl-aminoimidazole synthetase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (5'-phosphoribosylglycinamide transformylase) (GAR transformylase) (GART)] Trifunctional enzyme that catalyzes three distinct reactions as part of the 'de novo' inosine monophosphate biosynthetic pathway. {ECO:0000305|PubMed:12450384, ECO:0000305|PubMed:12755606, ECO:0000305|PubMed:20631005, ECO:0000305|PubMed:2183217}.
P10636 MAPT S355 SIGNOR Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}.
Q8N5S9 CAMKK1 S69 Sugiyama Calcium/calmodulin-dependent protein kinase kinase 1 (CaM-KK 1) (CaM-kinase kinase 1) (CaMKK 1) (EC 2.7.11.17) (CaM-kinase IV kinase) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-KK alpha) (CaM-kinase kinase alpha) (CaMKK alpha) Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. {ECO:0000269|PubMed:12935886}.
Q8TD08 MAPK15 S442 Sugiyama Mitogen-activated protein kinase 15 (MAP kinase 15) (MAPK 15) (EC 2.7.11.24) (Extracellular signal-regulated kinase 7) (ERK-7) (Extracellular signal-regulated kinase 8) (ERK-8) Atypical MAPK protein that regulates several process such as autophagy, ciliogenesis, protein trafficking/secretion and genome integrity, in a kinase activity-dependent manner (PubMed:20733054, PubMed:21847093, PubMed:22948227, PubMed:24618899, PubMed:29021280). Controls both, basal and starvation-induced autophagy throught its interaction with GABARAP, MAP1LC3B and GABARAPL1 leading to autophagosome formation, SQSTM1 degradation and reduced MAP1LC3B inhibitory phosphorylation (PubMed:22948227). Regulates primary cilium formation and the localization of ciliary proteins involved in cilium structure, transport, and signaling (PubMed:29021280). Prevents the relocation of the sugar-adding enzymes from the Golgi to the endoplasmic reticulum, thereby restricting the production of sugar-coated proteins (PubMed:24618899). Upon amino-acid starvation, mediates transitional endoplasmic reticulum site disassembly and inhibition of secretion (PubMed:21847093). Binds to chromatin leading to MAPK15 activation and interaction with PCNA, that which protects genomic integrity by inhibiting MDM2-mediated degradation of PCNA (PubMed:20733054). Regulates DA transporter (DAT) activity and protein expression via activation of RhoA (PubMed:28842414). In response to H(2)O(2) treatment phosphorylates ELAVL1, thus preventing it from binding to the PDCD4 3'UTR and rendering the PDCD4 mRNA accessible to miR-21 and leading to its degradation and loss of protein expression (PubMed:26595526). Also functions in a kinase activity-independent manner as a negative regulator of growth (By similarity). Phosphorylates in vitro FOS and MBP (PubMed:11875070, PubMed:16484222, PubMed:19166846, PubMed:20638370). During oocyte maturation, plays a key role in the microtubule organization and meiotic cell cycle progression in oocytes, fertilized eggs, and early embryos (By similarity). Interacts with ESRRA promoting its re-localization from the nucleus to the cytoplasm and then prevents its transcriptional activity (PubMed:21190936). {ECO:0000250|UniProtKB:Q80Y86, ECO:0000250|UniProtKB:Q9Z2A6, ECO:0000269|PubMed:11875070, ECO:0000269|PubMed:16484222, ECO:0000269|PubMed:19166846, ECO:0000269|PubMed:20638370, ECO:0000269|PubMed:20733054, ECO:0000269|PubMed:21190936, ECO:0000269|PubMed:21847093, ECO:0000269|PubMed:22948227, ECO:0000269|PubMed:24618899, ECO:0000269|PubMed:26595526, ECO:0000269|PubMed:28842414, ECO:0000269|PubMed:29021280}.
Q9H093 NUAK2 S492 Sugiyama NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (Omphalocele kinase 2) (SNF1/AMP kinase-related kinase) (SNARK) Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Phosphorylates LATS1 and LATS2. Plays a key role in neural tube closure during embryonic development through LATS2 phosphorylation and regulation of the nuclear localization of YAP1 a critical downstream regulatory target in the Hippo signaling pathway (PubMed:32845958). {ECO:0000269|PubMed:14575707, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15345718, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:32845958}.
Q01081 U2AF1 S19 Sugiyama Splicing factor U2AF 35 kDa subunit (U2 auxiliary factor 35 kDa subunit) (U2 small nuclear RNA auxiliary factor 1) (U2 snRNP auxiliary factor small subunit) Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron. {ECO:0000269|PubMed:22158538, ECO:0000269|PubMed:25311244, ECO:0000269|PubMed:8647433}.
Q8WU68 U2AF1L4 S19 Sugiyama Splicing factor U2AF 26 kDa subunit (U2 auxiliary factor 26) (U2 small nuclear RNA auxiliary factor 1-like protein 4) (U2AF1-like 4) (U2(RNU2) small nuclear RNA auxiliary factor 1-like protein 3) (U2 small nuclear RNA auxiliary factor 1-like protein 3) (U2AF1-like protein 3) RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3'-splice site (By similarity). Shows a preference for AGC or AGA (By similarity). {ECO:0000250|UniProtKB:Q8BGJ9}.
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reactome_id name p -log10_p
R-HSA-437239 Recycling pathway of L1 2.341236e-08 7.631
R-HSA-190828 Gap junction trafficking 3.032758e-07 6.518
R-HSA-9619483 Activation of AMPK downstream of NMDARs 4.619627e-07 6.335
R-HSA-157858 Gap junction trafficking and regulation 5.574872e-07 6.254
R-HSA-9668328 Sealing of the nuclear envelope (NE) by ESCRT-III 1.017665e-06 5.992
R-HSA-190840 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 1.274343e-06 5.895
R-HSA-190872 Transport of connexons to the plasma membrane 1.581126e-06 5.801
R-HSA-373760 L1CAM interactions 1.513437e-06 5.820
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 1.845728e-06 5.734
R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC 4.844547e-06 5.315
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 5.546181e-06 5.256
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 9.450012e-06 5.025
R-HSA-9833482 PKR-mediated signaling 9.450012e-06 5.025
R-HSA-389958 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 1.554327e-05 4.808
R-HSA-9663891 Selective autophagy 1.758145e-05 4.755
R-HSA-438064 Post NMDA receptor activation events 1.646205e-05 4.784
R-HSA-190861 Gap junction assembly 2.529872e-05 4.597
R-HSA-9646399 Aggrephagy 4.815585e-05 4.317
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 4.595227e-05 4.338
R-HSA-1632852 Macroautophagy 5.380319e-05 4.269
R-HSA-389977 Post-chaperonin tubulin folding pathway 5.990242e-05 4.223
R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors 5.854238e-05 4.233
R-HSA-8949215 Mitochondrial calcium ion transport 8.047248e-05 4.094
R-HSA-8955332 Carboxyterminal post-translational modifications of tubulin 1.003008e-04 3.999
R-HSA-9612973 Autophagy 1.043993e-04 3.981
R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC 1.203494e-04 3.920
R-HSA-9022534 Loss of MECP2 binding ability to 5hmC-DNA 1.319440e-04 3.880
R-HSA-913531 Interferon Signaling 1.339915e-04 3.873
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 1.636738e-04 3.786
R-HSA-8986944 Transcriptional Regulation by MECP2 1.926165e-04 3.715
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic 1.877382e-04 3.726
R-HSA-6807878 COPI-mediated anterograde transport 2.759377e-04 3.559
R-HSA-983189 Kinesins 2.662306e-04 3.575
R-HSA-422475 Axon guidance 2.447726e-04 3.611
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 3.037750e-04 3.517
R-HSA-9022692 Regulation of MECP2 expression and activity 3.247516e-04 3.488
R-HSA-70171 Glycolysis 3.349029e-04 3.475
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 4.407437e-04 3.356
R-HSA-9675108 Nervous system development 4.600013e-04 3.337
R-HSA-1852241 Organelle biogenesis and maintenance 5.302911e-04 3.275
R-HSA-5620920 Cargo trafficking to the periciliary membrane 5.245511e-04 3.280
R-HSA-446353 Cell-extracellular matrix interactions 5.492470e-04 3.260
R-HSA-9022538 Loss of MECP2 binding ability to 5mC-DNA 8.114711e-04 3.091
R-HSA-70326 Glucose metabolism 7.925934e-04 3.101
R-HSA-2132295 MHC class II antigen presentation 9.965624e-04 3.001
R-HSA-9022927 MECP2 regulates transcription of genes involved in GABA signaling 1.162268e-03 2.935
R-HSA-5620924 Intraflagellar transport 1.240494e-03 2.906
R-HSA-70263 Gluconeogenesis 1.240494e-03 2.906
R-HSA-390466 Chaperonin-mediated protein folding 1.244840e-03 2.905
R-HSA-9022535 Loss of phosphorylation of MECP2 at T308 1.573519e-03 2.803
R-HSA-69275 G2/M Transition 1.601414e-03 2.795
R-HSA-391251 Protein folding 1.621386e-03 2.790
R-HSA-453274 Mitotic G2-G2/M phases 1.691237e-03 2.772
R-HSA-9022537 Loss of MECP2 binding ability to the NCoR/SMRT complex 2.044229e-03 2.689
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 1.994149e-03 2.700
R-HSA-1266695 Interleukin-7 signaling 2.221064e-03 2.653
R-HSA-445095 Interaction between L1 and Ankyrins 2.647643e-03 2.577
R-HSA-199977 ER to Golgi Anterograde Transport 2.528068e-03 2.597
R-HSA-1640170 Cell Cycle 2.744257e-03 2.562
R-HSA-9022707 MECP2 regulates transcription factors 3.160104e-03 2.500
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 3.178597e-03 2.498
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 3.368981e-03 2.473
R-HSA-68882 Mitotic Anaphase 3.488227e-03 2.457
R-HSA-2555396 Mitotic Metaphase and Anaphase 3.569112e-03 2.447
R-HSA-196025 Formation of annular gap junctions 3.803337e-03 2.420
R-HSA-176187 Activation of ATR in response to replication stress 4.217544e-03 2.375
R-HSA-190873 Gap junction degradation 4.502166e-03 2.347
R-HSA-9022702 MECP2 regulates transcription of neuronal ligands 5.255654e-03 2.279
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 5.321946e-03 2.274
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 5.518624e-03 2.258
R-HSA-68886 M Phase 6.210945e-03 2.207
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 6.438456e-03 2.191
R-HSA-201556 Signaling by ALK 6.639828e-03 2.178
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 6.690948e-03 2.175
R-HSA-4839748 Signaling by AMER1 mutants 6.922919e-03 2.160
R-HSA-5617833 Cilium Assembly 7.819206e-03 2.107
R-HSA-9609646 HCMV Infection 7.134484e-03 2.147
R-HSA-8856688 Golgi-to-ER retrograde transport 7.752236e-03 2.111
R-HSA-381183 ATF6 (ATF6-alpha) activates chaperone genes 6.922919e-03 2.160
R-HSA-9005895 Pervasive developmental disorders 7.834878e-03 2.106
R-HSA-9005891 Loss of function of MECP2 in Rett syndrome 7.834878e-03 2.106
R-HSA-9697154 Disorders of Nervous System Development 7.834878e-03 2.106
R-HSA-5688426 Deubiquitination 7.846984e-03 2.105
R-HSA-5467343 Deletions in the AMER1 gene destabilize the destruction complex 8.163977e-03 2.088
R-HSA-68877 Mitotic Prometaphase 8.351484e-03 2.078
R-HSA-1280215 Cytokine Signaling in Immune system 8.382106e-03 2.077
R-HSA-381033 ATF6 (ATF6-alpha) activates chaperones 8.797862e-03 2.056
R-HSA-9609690 HCMV Early Events 8.909356e-03 2.050
R-HSA-69278 Cell Cycle, Mitotic 9.207845e-03 2.036
R-HSA-9701898 STAT3 nuclear events downstream of ALK signaling 1.087339e-02 1.964
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 9.694126e-03 2.013
R-HSA-948021 Transport to the Golgi and subsequent modification 1.010449e-02 1.995
R-HSA-9675151 Disorders of Developmental Biology 1.314259e-02 1.881
R-HSA-72187 mRNA 3'-end processing 1.356808e-02 1.867
R-HSA-5610787 Hedgehog 'off' state 1.358896e-02 1.867
R-HSA-9913635 Strand-asynchronous mitochondrial DNA replication 1.689480e-02 1.772
R-HSA-2467813 Separation of Sister Chromatids 1.753891e-02 1.756
R-HSA-73856 RNA Polymerase II Transcription Termination 1.957450e-02 1.708
R-HSA-5689880 Ub-specific processing proteases 2.150236e-02 1.668
R-HSA-5628897 TP53 Regulates Metabolic Genes 2.163369e-02 1.665
R-HSA-1592230 Mitochondrial biogenesis 2.329971e-02 1.633
R-HSA-112315 Transmission across Chemical Synapses 2.348621e-02 1.629
R-HSA-5674404 PTEN Loss of Function in Cancer 2.429401e-02 1.615
R-HSA-8943723 Regulation of PTEN mRNA translation 2.402355e-02 1.619
R-HSA-9636667 Manipulation of host energy metabolism 2.429401e-02 1.615
R-HSA-163282 Mitochondrial transcription initiation 2.429401e-02 1.615
R-HSA-8868773 rRNA processing in the nucleus and cytosol 2.847343e-02 1.546
R-HSA-8953854 Metabolism of RNA 2.392177e-02 1.621
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 2.860959e-02 1.543
R-HSA-9022699 MECP2 regulates neuronal receptors and channels 2.879160e-02 1.541
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 2.952341e-02 1.530
R-HSA-69481 G2/M Checkpoints 3.006426e-02 1.522
R-HSA-187037 Signaling by NTRK1 (TRKA) 3.073095e-02 1.512
R-HSA-5205685 PINK1-PRKN Mediated Mitophagy 3.216234e-02 1.493
R-HSA-75944 Transcription from mitochondrial promoters 3.226113e-02 1.491
R-HSA-109582 Hemostasis 3.334663e-02 1.477
R-HSA-9709570 Impaired BRCA2 binding to RAD51 3.390316e-02 1.470
R-HSA-9913351 Formation of the dystrophin-glycoprotein complex (DGC) 3.749218e-02 1.426
R-HSA-9034793 Activated NTRK3 signals through PLCG1 4.016369e-02 1.396
R-HSA-167021 PLC-gamma1 signalling 4.016369e-02 1.396
R-HSA-9026527 Activated NTRK2 signals through PLCG1 4.800219e-02 1.319
R-HSA-1251932 PLCG1 events in ERBB2 signaling 4.800219e-02 1.319
R-HSA-5685938 HDR through Single Strand Annealing (SSA) 4.121980e-02 1.385
R-HSA-4791275 Signaling by WNT in cancer 3.933901e-02 1.405
R-HSA-5205647 Mitophagy 4.508062e-02 1.346
R-HSA-9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function 4.508062e-02 1.346
R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol 4.121980e-02 1.385
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 4.705934e-02 1.327
R-HSA-9675136 Diseases of DNA Double-Strand Break Repair 4.508062e-02 1.346
R-HSA-5358351 Signaling by Hedgehog 3.941269e-02 1.404
R-HSA-166520 Signaling by NTRKs 4.848177e-02 1.314
R-HSA-8853659 RET signaling 4.906940e-02 1.309
R-HSA-199991 Membrane Trafficking 4.915077e-02 1.308
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 5.111018e-02 1.291
R-HSA-5689896 Ovarian tumor domain proteases 5.111018e-02 1.291
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange 5.318103e-02 1.274
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 5.528135e-02 1.257
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 5.741053e-02 1.241
R-HSA-5674135 MAP2K and MAPK activation 6.175303e-02 1.209
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 5.956795e-02 1.225
R-HSA-9656223 Signaling by RAF1 mutants 6.175303e-02 1.209
R-HSA-9649948 Signaling downstream of RAS mutants 7.307297e-02 1.136
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 7.307297e-02 1.136
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 7.307297e-02 1.136
R-HSA-199920 CREB phosphorylation 7.113856e-02 1.148
R-HSA-69478 G2/M DNA replication checkpoint 7.113856e-02 1.148
R-HSA-6802949 Signaling by RAS mutants 7.307297e-02 1.136
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 7.084855e-02 1.150
R-HSA-72312 rRNA processing 5.730795e-02 1.242
R-HSA-8849468 PTK6 Regulates Proteins Involved in RNA Processing 5.577717e-02 1.254
R-HSA-1489509 DAG and IP3 signaling 7.075827e-02 1.150
R-HSA-168256 Immune System 6.801449e-02 1.167
R-HSA-597592 Post-translational protein modification 5.695371e-02 1.244
R-HSA-9637690 Response of Mtb to phagocytosis 6.620382e-02 1.179
R-HSA-168316 Assembly of Viral Components at the Budding Site 5.577717e-02 1.254
R-HSA-75153 Apoptotic execution phase 7.307297e-02 1.136
R-HSA-3928662 EPHB-mediated forward signaling 6.846837e-02 1.165
R-HSA-9675135 Diseases of DNA repair 7.307297e-02 1.136
R-HSA-446203 Asparagine N-linked glycosylation 7.310368e-02 1.136
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 7.467223e-02 1.127
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 7.516163e-02 1.124
R-HSA-9700206 Signaling by ALK in cancer 7.516163e-02 1.124
R-HSA-3928665 EPH-ephrin mediated repulsion of cells 7.541191e-02 1.123
R-HSA-8948747 Regulation of PTEN localization 7.872598e-02 1.104
R-HSA-212718 EGFR interacts with phospholipase C-gamma 8.625190e-02 1.064
R-HSA-9027277 Erythropoietin activates Phospholipase C gamma (PLCG) 1.011212e-01 0.995
R-HSA-390450 Folding of actin by CCT/TriC 1.011212e-01 0.995
R-HSA-933543 NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 1.084655e-01 0.965
R-HSA-5467340 AXIN missense mutants destabilize the destruction complex 1.084655e-01 0.965
R-HSA-5467348 Truncations of AMER1 destabilize the destruction complex 1.084655e-01 0.965
R-HSA-5467337 APC truncation mutants have impaired AXIN binding 1.084655e-01 0.965
R-HSA-5339716 Signaling by GSK3beta mutants 1.157503e-01 0.936
R-HSA-4839743 Signaling by CTNNB1 phospho-site mutants 1.229760e-01 0.910
R-HSA-3000484 Scavenging by Class F Receptors 1.229760e-01 0.910
R-HSA-5358751 CTNNB1 S45 mutants aren't phosphorylated 1.229760e-01 0.910
R-HSA-5358747 CTNNB1 S33 mutants aren't phosphorylated 1.229760e-01 0.910
R-HSA-5358749 CTNNB1 S37 mutants aren't phosphorylated 1.229760e-01 0.910
R-HSA-5358752 CTNNB1 T41 mutants aren't phosphorylated 1.229760e-01 0.910
R-HSA-5654227 Phospholipase C-mediated cascade; FGFR3 1.372520e-01 0.862
R-HSA-196299 Beta-catenin phosphorylation cascade 1.443033e-01 0.841
R-HSA-5654228 Phospholipase C-mediated cascade; FGFR4 1.443033e-01 0.841
R-HSA-5083636 Defective GALNT12 causes CRCS1 1.512974e-01 0.820
R-HSA-5083625 Defective GALNT3 causes HFTC 1.512974e-01 0.820
R-HSA-77595 Processing of Intronless Pre-mRNAs 1.582348e-01 0.801
R-HSA-5654219 Phospholipase C-mediated cascade: FGFR1 1.651159e-01 0.782
R-HSA-5083632 Defective C1GALT1C1 causes TNPS 1.651159e-01 0.782
R-HSA-5654221 Phospholipase C-mediated cascade; FGFR2 1.854260e-01 0.732
R-HSA-9934037 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 1.854260e-01 0.732
R-HSA-912526 Interleukin receptor SHC signaling 2.117453e-01 0.674
R-HSA-977068 Termination of O-glycan biosynthesis 2.117453e-01 0.674
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 1.157101e-01 0.937
R-HSA-380259 Loss of Nlp from mitotic centrosomes 1.157101e-01 0.937
R-HSA-8854518 AURKA Activation by TPX2 1.237769e-01 0.907
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 1.430933e-01 0.844
R-HSA-380287 Centrosome maturation 1.487249e-01 0.828
R-HSA-9954714 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA 1.981098e-01 0.703
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 2.010797e-01 0.697
R-HSA-9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... 2.130090e-01 0.672
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 1.951456e-01 0.710
R-HSA-8943724 Regulation of PTEN gene transcription 1.077867e-01 0.967
R-HSA-927802 Nonsense-Mediated Decay (NMD) 8.264018e-02 1.083
R-HSA-8983432 Interleukin-15 signaling 1.229760e-01 0.910
R-HSA-9020958 Interleukin-21 signaling 9.371680e-02 1.028
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 1.210727e-01 0.917
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 8.264018e-02 1.083
R-HSA-156902 Peptide chain elongation 1.892349e-01 0.723
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 1.004789e-01 0.998
R-HSA-2465910 MASTL Facilitates Mitotic Progression 9.371680e-02 1.028
R-HSA-6807070 PTEN Regulation 1.372229e-01 0.863
R-HSA-6798695 Neutrophil degranulation 1.997079e-01 0.700
R-HSA-9954709 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide 2.160025e-01 0.666
R-HSA-72764 Eukaryotic Translation Termination 2.160025e-01 0.666
R-HSA-9020558 Interleukin-2 signaling 1.084655e-01 0.965
R-HSA-195253 Degradation of beta-catenin by the destruction complex 1.347358e-01 0.871
R-HSA-918233 TRAF3-dependent IRF activation pathway 1.582348e-01 0.801
R-HSA-8985947 Interleukin-9 signaling 8.625190e-02 1.064
R-HSA-6802957 Oncogenic MAPK signaling 1.774935e-01 0.751
R-HSA-9619229 Activation of RAC1 downstream of NMDARs 9.371680e-02 1.028
R-HSA-176974 Unwinding of DNA 9.371680e-02 1.028
R-HSA-4839744 Signaling by APC mutants 1.084655e-01 0.965
R-HSA-4839735 Signaling by AXIN mutants 1.157503e-01 0.936
R-HSA-418890 Role of second messengers in netrin-1 signaling 1.229760e-01 0.910
R-HSA-9933947 Formation of the non-canonical BAF (ncBAF) complex 1.301431e-01 0.886
R-HSA-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 1.512974e-01 0.820
R-HSA-75067 Processing of Capped Intronless Pre-mRNA 2.181921e-01 0.661
R-HSA-933542 TRAF6 mediated NF-kB activation 2.181921e-01 0.661
R-HSA-72689 Formation of a pool of free 40S subunits 2.160025e-01 0.666
R-HSA-156842 Eukaryotic Translation Elongation 2.040548e-01 0.690
R-HSA-9006925 Intracellular signaling by second messengers 1.773198e-01 0.751
R-HSA-375165 NCAM signaling for neurite out-growth 1.130524e-01 0.947
R-HSA-428359 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... 1.011212e-01 0.995
R-HSA-418359 Reduction of cytosolic Ca++ levels 1.157503e-01 0.936
R-HSA-9018681 Biosynthesis of protectins 1.372520e-01 0.862
R-HSA-5218921 VEGFR2 mediated cell proliferation 2.245867e-01 0.649
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 1.745766e-01 0.758
R-HSA-69306 DNA Replication 1.661422e-01 0.780
R-HSA-442729 CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde 8.625190e-02 1.064
R-HSA-9932451 SWI/SNF chromatin remodelers 2.245867e-01 0.649
R-HSA-9932444 ATP-dependent chromatin remodelers 2.245867e-01 0.649
R-HSA-198753 ERK/MAPK targets 1.920865e-01 0.717
R-HSA-168273 Influenza Viral RNA Transcription and Replication 1.701278e-01 0.769
R-HSA-114608 Platelet degranulation 1.120160e-01 0.951
R-HSA-426117 Cation-coupled Chloride cotransporters 7.872598e-02 1.104
R-HSA-425561 Sodium/Calcium exchangers 1.157503e-01 0.936
R-HSA-429947 Deadenylation of mRNA 2.181921e-01 0.661
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 2.113633e-01 0.675
R-HSA-5693607 Processing of DNA double-strand break ends 1.658752e-01 0.780
R-HSA-111932 CaMK IV-mediated phosphorylation of CREB 1.011212e-01 0.995
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 1.243839e-01 0.905
R-HSA-5655291 Signaling by FGFR4 in disease 1.372520e-01 0.862
R-HSA-9933937 Formation of the canonical BAF (cBAF) complex 1.372520e-01 0.862
R-HSA-9933946 Formation of the embryonic stem cell BAF (esBAF) complex 1.443033e-01 0.841
R-HSA-3270619 IRF3-mediated induction of type I IFN 1.443033e-01 0.841
R-HSA-9020265 Biosynthesis of aspirin-triggered D-series resolvins 1.651159e-01 0.782
R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation 2.309293e-01 0.637
R-HSA-9764561 Regulation of CDH1 Function 1.000187e-01 1.000
R-HSA-1169408 ISG15 antiviral mechanism 1.487249e-01 0.828
R-HSA-9018676 Biosynthesis of D-series resolvins 2.052457e-01 0.688
R-HSA-140342 Apoptosis induced DNA fragmentation 1.011212e-01 0.995
R-HSA-9933939 Formation of the polybromo-BAF (pBAF) complex 1.372520e-01 0.862
R-HSA-5637812 Signaling by EGFRvIII in Cancer 1.651159e-01 0.782
R-HSA-5637810 Constitutive Signaling by EGFRvIII 1.651159e-01 0.782
R-HSA-5653656 Vesicle-mediated transport 7.916567e-02 1.101
R-HSA-9034015 Signaling by NTRK3 (TRKC) 1.986929e-01 0.702
R-HSA-5693532 DNA Double-Strand Break Repair 1.661422e-01 0.780
R-HSA-1483249 Inositol phosphate metabolism 8.264018e-02 1.083
R-HSA-9665686 Signaling by ERBB2 TMD/JMD mutants 2.181921e-01 0.661
R-HSA-9659379 Sensory processing of sound 1.601187e-01 0.796
R-HSA-210990 PECAM1 interactions 1.084655e-01 0.965
R-HSA-9635465 Suppression of apoptosis 1.084655e-01 0.965
R-HSA-9856872 Malate-aspartate shuttle 1.372520e-01 0.862
R-HSA-9023661 Biosynthesis of E-series 18(R)-resolvins 1.372520e-01 0.862
R-HSA-1643713 Signaling by EGFR in Cancer 2.309293e-01 0.637
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 1.292287e-01 0.889
R-HSA-168255 Influenza Infection 8.082130e-02 1.092
R-HSA-2028269 Signaling by Hippo 1.651159e-01 0.782
R-HSA-9665348 Signaling by ERBB2 ECD mutants 1.719412e-01 0.765
R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 1.920865e-01 0.717
R-HSA-5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer 1.920865e-01 0.717
R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea 9.746602e-02 1.011
R-HSA-392499 Metabolism of proteins 1.337291e-01 0.874
R-HSA-430116 GP1b-IX-V activation signalling 9.371680e-02 1.028
R-HSA-9018896 Biosynthesis of E-series 18(S)-resolvins 1.920865e-01 0.717
R-HSA-9031628 NGF-stimulated transcription 7.777455e-02 1.109
R-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins 9.371680e-02 1.028
R-HSA-69620 Cell Cycle Checkpoints 1.950831e-01 0.710
R-HSA-5621575 CD209 (DC-SIGN) signaling 2.181921e-01 0.661
R-HSA-1660514 Synthesis of PIPs at the Golgi membrane 2.309293e-01 0.637
R-HSA-69473 G2/M DNA damage checkpoint 1.459034e-01 0.836
R-HSA-210993 Tie2 Signaling 1.719412e-01 0.765
R-HSA-2173788 Downregulation of TGF-beta receptor signaling 2.052457e-01 0.688
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in ... 2.052457e-01 0.688
R-HSA-8983711 OAS antiviral response 1.229760e-01 0.910
R-HSA-156711 Polo-like kinase mediated events 1.719412e-01 0.765
R-HSA-4420097 VEGFA-VEGFR2 Pathway 9.042620e-02 1.044
R-HSA-9725371 Nuclear events stimulated by ALK signaling in cancer 7.777455e-02 1.109
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 1.506354e-01 0.822
R-HSA-73894 DNA Repair 2.025475e-01 0.693
R-HSA-162582 Signal Transduction 1.581844e-01 0.801
R-HSA-3000171 Non-integrin membrane-ECM interactions 1.487249e-01 0.828
R-HSA-194138 Signaling by VEGF 1.085742e-01 0.964
R-HSA-9824446 Viral Infection Pathways 1.481020e-01 0.829
R-HSA-1834941 STING mediated induction of host immune responses 1.787110e-01 0.748
R-HSA-5663205 Infectious disease 1.630058e-01 0.788
R-HSA-168268 Virus Assembly and Release 1.512974e-01 0.820
R-HSA-112316 Neuronal System 1.083263e-01 0.965
R-HSA-5685942 HDR through Homologous Recombination (HRR) 1.264956e-01 0.898
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 1.833501e-01 0.737
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 1.971905e-01 0.705
R-HSA-2682334 EPH-Ephrin signaling 2.040548e-01 0.690
R-HSA-9679504 Translation of Replicase and Assembly of the Replication Transcription Complex 1.719412e-01 0.765
R-HSA-9694676 Translation of Replicase and Assembly of the Replication Transcription Complex 2.052457e-01 0.688
R-HSA-3700989 Transcriptional Regulation by TP53 1.057901e-01 0.976
R-HSA-2262752 Cellular responses to stress 2.329115e-01 0.633
R-HSA-2408557 Selenocysteine synthesis 2.340366e-01 0.631
R-HSA-1483255 PI Metabolism 2.370521e-01 0.625
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane 2.372204e-01 0.625
R-HSA-5655332 Signaling by FGFR3 in disease 2.372204e-01 0.625
R-HSA-9006115 Signaling by NTRK2 (TRKB) 2.372204e-01 0.625
R-HSA-192823 Viral mRNA Translation 2.400698e-01 0.620
R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency 2.430895e-01 0.614
R-HSA-171319 Telomere Extension By Telomerase 2.434605e-01 0.614
R-HSA-5620971 Pyroptosis 2.434605e-01 0.614
R-HSA-5673001 RAF/MAP kinase cascade 2.485028e-01 0.605
R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT) 2.496498e-01 0.603
R-HSA-9615710 Late endosomal microautophagy 2.496498e-01 0.603
R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases 2.496498e-01 0.603
R-HSA-5656169 Termination of translesion DNA synthesis 2.496498e-01 0.603
R-HSA-5654708 Downstream signaling of activated FGFR3 2.496498e-01 0.603
R-HSA-418360 Platelet calcium homeostasis 2.496498e-01 0.603
R-HSA-9006335 Signaling by Erythropoietin 2.496498e-01 0.603
R-HSA-9664565 Signaling by ERBB2 KD Mutants 2.496498e-01 0.603
R-HSA-9018679 Biosynthesis of EPA-derived SPMs 2.496498e-01 0.603
R-HSA-72163 mRNA Splicing - Major Pathway 2.545132e-01 0.594
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 2.551829e-01 0.593
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 2.557890e-01 0.592
R-HSA-68962 Activation of the pre-replicative complex 2.557890e-01 0.592
R-HSA-2424491 DAP12 signaling 2.557890e-01 0.592
R-HSA-5654716 Downstream signaling of activated FGFR4 2.557890e-01 0.592
R-HSA-1227990 Signaling by ERBB2 in Cancer 2.557890e-01 0.592
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 2.582088e-01 0.588
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 2.582088e-01 0.588
R-HSA-5684996 MAPK1/MAPK3 signaling 2.610004e-01 0.583
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 2.618783e-01 0.582
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 2.618783e-01 0.582
R-HSA-9820960 Respiratory syncytial virus (RSV) attachment and entry 2.618783e-01 0.582
R-HSA-162588 Budding and maturation of HIV virion 2.618783e-01 0.582
R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling 2.618783e-01 0.582
R-HSA-186763 Downstream signal transduction 2.618783e-01 0.582
R-HSA-9833109 Evasion by RSV of host interferon responses 2.618783e-01 0.582
R-HSA-8963693 Aspartate and asparagine metabolism 2.618783e-01 0.582
R-HSA-202403 TCR signaling 2.642623e-01 0.578
R-HSA-69190 DNA strand elongation 2.679181e-01 0.572
R-HSA-111465 Apoptotic cleavage of cellular proteins 2.679181e-01 0.572
R-HSA-1855170 IPs transport between nucleus and cytosol 2.739089e-01 0.562
R-HSA-159227 Transport of the SLBP independent Mature mRNA 2.739089e-01 0.562
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 2.739089e-01 0.562
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 2.763699e-01 0.559
R-HSA-72172 mRNA Splicing 2.787712e-01 0.555
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 2.798510e-01 0.553
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 2.798510e-01 0.553
R-HSA-5696394 DNA Damage Recognition in GG-NER 2.798510e-01 0.553
R-HSA-8964539 Glutamate and glutamine metabolism 2.798510e-01 0.553
R-HSA-5357801 Programmed Cell Death 2.809889e-01 0.551
R-HSA-909733 Interferon alpha/beta signaling 2.854450e-01 0.544
R-HSA-180746 Nuclear import of Rev protein 2.857449e-01 0.544
R-HSA-901042 Calnexin/calreticulin cycle 2.857449e-01 0.544
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 2.857449e-01 0.544
R-HSA-72613 Eukaryotic Translation Initiation 2.884679e-01 0.540
R-HSA-72737 Cap-dependent Translation Initiation 2.884679e-01 0.540
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 2.915908e-01 0.535
R-HSA-5654696 Downstream signaling of activated FGFR2 2.915908e-01 0.535
R-HSA-5654687 Downstream signaling of activated FGFR1 2.915908e-01 0.535
R-HSA-5693538 Homology Directed Repair 2.945095e-01 0.531
R-HSA-111933 Calmodulin induced events 2.973893e-01 0.527
R-HSA-111997 CaM pathway 2.973893e-01 0.527
R-HSA-68875 Mitotic Prophase 3.005444e-01 0.522
R-HSA-933541 TRAF6 mediated IRF7 activation 3.031407e-01 0.518
R-HSA-180910 Vpr-mediated nuclear import of PICs 3.031407e-01 0.518
R-HSA-9635486 Infection with Mycobacterium tuberculosis 3.035588e-01 0.518
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 3.088454e-01 0.510
R-HSA-9958790 SLC-mediated transport of inorganic anions 3.088454e-01 0.510
R-HSA-1643685 Disease 3.090750e-01 0.510
R-HSA-9816359 Maternal to zygotic transition (MZT) 3.095809e-01 0.509
R-HSA-168249 Innate Immune System 3.139052e-01 0.503
R-HSA-168276 NS1 Mediated Effects on Host Pathways 3.145037e-01 0.502
R-HSA-451927 Interleukin-2 family signaling 3.201161e-01 0.495
R-HSA-202433 Generation of second messenger molecules 3.201161e-01 0.495
R-HSA-177243 Interactions of Rev with host cellular proteins 3.201161e-01 0.495
R-HSA-176033 Interactions of Vpr with host cellular proteins 3.201161e-01 0.495
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 3.256828e-01 0.487
R-HSA-73817 Purine ribonucleoside monophosphate biosynthesis 3.256828e-01 0.487
R-HSA-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... 3.256828e-01 0.487
R-HSA-3000480 Scavenging by Class A Receptors 3.312043e-01 0.480
R-HSA-5655302 Signaling by FGFR1 in disease 3.312043e-01 0.480
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling 3.366809e-01 0.473
R-HSA-111996 Ca-dependent events 3.366809e-01 0.473
R-HSA-379716 Cytosolic tRNA aminoacylation 3.366809e-01 0.473
R-HSA-5654743 Signaling by FGFR4 3.421130e-01 0.466
R-HSA-2173789 TGF-beta receptor signaling activates SMADs 3.421130e-01 0.466
R-HSA-2172127 DAP12 interactions 3.475010e-01 0.459
R-HSA-373752 Netrin-1 signaling 3.475010e-01 0.459
R-HSA-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX) 3.475010e-01 0.459
R-HSA-5683826 Surfactant metabolism 3.475010e-01 0.459
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 3.528452e-01 0.452
R-HSA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation 3.528452e-01 0.452
R-HSA-5654741 Signaling by FGFR3 3.528452e-01 0.452
R-HSA-1614558 Degradation of cysteine and homocysteine 3.528452e-01 0.452
R-HSA-5683057 MAPK family signaling cascades 3.546582e-01 0.450
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 3.581459e-01 0.446
R-HSA-8953897 Cellular responses to stimuli 3.596840e-01 0.444
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 3.602391e-01 0.443
R-HSA-9948299 Ribosome-associated quality control 3.631812e-01 0.440
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network 3.634036e-01 0.440
R-HSA-381119 Unfolded Protein Response (UPR) 3.661183e-01 0.436
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 3.686185e-01 0.433
R-HSA-425410 Metal ion SLC transporters 3.686185e-01 0.433
R-HSA-9664422 FCGR3A-mediated phagocytosis 3.690503e-01 0.433
R-HSA-9664407 Parasite infection 3.690503e-01 0.433
R-HSA-9664417 Leishmania phagocytosis 3.690503e-01 0.433
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 3.719770e-01 0.429
R-HSA-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle 3.737910e-01 0.427
R-HSA-73893 DNA Damage Bypass 3.737910e-01 0.427
R-HSA-389661 Glyoxylate metabolism and glycine degradation 3.737910e-01 0.427
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 3.778144e-01 0.423
R-HSA-162599 Late Phase of HIV Life Cycle 3.778144e-01 0.423
R-HSA-1280218 Adaptive Immune System 3.780109e-01 0.422
R-HSA-5655253 Signaling by FGFR2 in disease 3.789214e-01 0.421
R-HSA-9748787 Azathioprine ADME 3.789214e-01 0.421
R-HSA-8856828 Clathrin-mediated endocytosis 3.807249e-01 0.419
R-HSA-68949 Orc1 removal from chromatin 3.890575e-01 0.410
R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins 3.890575e-01 0.410
R-HSA-9692916 SARS-CoV-1 activates/modulates innate immune responses 3.890575e-01 0.410
R-HSA-8948751 Regulation of PTEN stability and activity 3.940638e-01 0.404
R-HSA-5250924 B-WICH complex positively regulates rRNA expression 3.940638e-01 0.404
R-HSA-8956320 Nucleotide biosynthesis 3.940638e-01 0.404
R-HSA-9753281 Paracetamol ADME 4.039546e-01 0.394
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 4.066527e-01 0.391
R-HSA-5654736 Signaling by FGFR1 4.088397e-01 0.388
R-HSA-177929 Signaling by EGFR 4.088397e-01 0.388
R-HSA-5578775 Ion homeostasis 4.088397e-01 0.388
R-HSA-2980766 Nuclear Envelope Breakdown 4.136851e-01 0.383
R-HSA-5621480 Dectin-2 family 4.136851e-01 0.383
R-HSA-1483166 Synthesis of PA 4.136851e-01 0.383
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 4.136851e-01 0.383
R-HSA-9772572 Early SARS-CoV-2 Infection Events 4.184911e-01 0.378
R-HSA-9610379 HCMV Late Events 4.208341e-01 0.376
R-HSA-162587 HIV Life Cycle 4.208341e-01 0.376
R-HSA-194441 Metabolism of non-coding RNA 4.232580e-01 0.373
R-HSA-191859 snRNP Assembly 4.232580e-01 0.373
R-HSA-180786 Extension of Telomeres 4.232580e-01 0.373
R-HSA-429914 Deadenylation-dependent mRNA decay 4.232580e-01 0.373
R-HSA-9711097 Cellular response to starvation 4.236500e-01 0.373
R-HSA-877300 Interferon gamma signaling 4.264589e-01 0.370
R-HSA-9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 4.279861e-01 0.369
R-HSA-1227986 Signaling by ERBB2 4.279861e-01 0.369
R-HSA-379724 tRNA Aminoacylation 4.279861e-01 0.369
R-HSA-5633007 Regulation of TP53 Activity 4.292607e-01 0.367
R-HSA-168325 Viral Messenger RNA Synthesis 4.326757e-01 0.364
R-HSA-450294 MAP kinase activation 4.326757e-01 0.364
R-HSA-112043 PLC beta mediated events 4.326757e-01 0.364
R-HSA-76002 Platelet activation, signaling and aggregation 4.338811e-01 0.363
R-HSA-109581 Apoptosis 4.348430e-01 0.362
R-HSA-6784531 tRNA processing in the nucleus 4.373272e-01 0.359
R-HSA-186797 Signaling by PDGF 4.373272e-01 0.359
R-HSA-1268020 Mitochondrial protein import 4.373272e-01 0.359
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 4.373272e-01 0.359
R-HSA-2408522 Selenoamino acid metabolism 4.403963e-01 0.356
R-HSA-6790901 rRNA modification in the nucleus and cytosol 4.419408e-01 0.355
R-HSA-373755 Semaphorin interactions 4.419408e-01 0.355
R-HSA-8848021 Signaling by PTK6 4.419408e-01 0.355
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 4.419408e-01 0.355
R-HSA-446728 Cell junction organization 4.424965e-01 0.354
R-HSA-9824443 Parasitic Infection Pathways 4.489256e-01 0.348
R-HSA-9658195 Leishmania infection 4.489256e-01 0.348
R-HSA-112040 G-protein mediated events 4.600228e-01 0.337
R-HSA-5621481 C-type lectin receptors (CLRs) 4.623084e-01 0.335
R-HSA-913709 O-linked glycosylation of mucins 4.644517e-01 0.333
R-HSA-5218859 Regulated Necrosis 4.644517e-01 0.333
R-HSA-74160 Gene expression (Transcription) 4.669767e-01 0.331
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 4.677088e-01 0.330
R-HSA-9764265 Regulation of CDH1 Expression and Function 4.677088e-01 0.330
R-HSA-9678108 SARS-CoV-1 Infection 4.730774e-01 0.325
R-HSA-448424 Interleukin-17 signaling 4.732017e-01 0.325
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 4.732017e-01 0.325
R-HSA-3906995 Diseases associated with O-glycosylation of proteins 4.775233e-01 0.321
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 4.775233e-01 0.321
R-HSA-1257604 PIP3 activates AKT signaling 4.785232e-01 0.320
R-HSA-1483257 Phospholipid metabolism 4.785232e-01 0.320
R-HSA-5578749 Transcriptional regulation by small RNAs 4.818097e-01 0.317
R-HSA-499943 Interconversion of nucleotide di- and triphosphates 4.818097e-01 0.317
R-HSA-69052 Switching of origins to a post-replicative state 4.860613e-01 0.313
R-HSA-1226099 Signaling by FGFR in disease 4.902782e-01 0.310
R-HSA-8852135 Protein ubiquitination 4.944607e-01 0.306
R-HSA-5689603 UCH proteinases 4.986093e-01 0.302
R-HSA-5654738 Signaling by FGFR2 5.148681e-01 0.288
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 5.173718e-01 0.286
R-HSA-9018677 Biosynthesis of DHA-derived SPMs 5.188504e-01 0.285
R-HSA-1500931 Cell-Cell communication 5.214954e-01 0.283
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 5.274340e-01 0.278
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 5.306036e-01 0.275
R-HSA-1614635 Sulfur amino acid metabolism 5.420719e-01 0.266
R-HSA-376176 Signaling by ROBO receptors 5.447023e-01 0.264
R-HSA-70268 Pyruvate metabolism 5.458325e-01 0.263
R-HSA-73857 RNA Polymerase II Transcription 5.480598e-01 0.261
R-HSA-1236974 ER-Phagosome pathway 5.532620e-01 0.257
R-HSA-1266738 Developmental Biology 5.536545e-01 0.257
R-HSA-202424 Downstream TCR signaling 5.569314e-01 0.254
R-HSA-68867 Assembly of the pre-replicative complex 5.713123e-01 0.243
R-HSA-9837999 Mitochondrial protein degradation 5.748345e-01 0.240
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 5.783280e-01 0.238
R-HSA-418990 Adherens junctions interactions 5.825158e-01 0.235
R-HSA-9694516 SARS-CoV-2 Infection 5.849790e-01 0.233
R-HSA-157579 Telomere Maintenance 5.886385e-01 0.230
R-HSA-170834 Signaling by TGF-beta Receptor Complex 5.886385e-01 0.230
R-HSA-8951664 Neddylation 5.893463e-01 0.230
R-HSA-8957275 Post-translational protein phosphorylation 5.920195e-01 0.228
R-HSA-190236 Signaling by FGFR 5.920195e-01 0.228
R-HSA-975871 MyD88 cascade initiated on plasma membrane 5.920195e-01 0.228
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 5.920195e-01 0.228
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 5.920195e-01 0.228
R-HSA-3214847 HATs acetylate histones 5.953728e-01 0.225
R-HSA-382556 ABC-family proteins mediated transport 5.986988e-01 0.223
R-HSA-162906 HIV Infection 6.027598e-01 0.220
R-HSA-9705683 SARS-CoV-2-host interactions 6.049633e-01 0.218
R-HSA-9842860 Regulation of endogenous retroelements 6.052696e-01 0.218
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 6.052696e-01 0.218
R-HSA-111885 Opioid Signalling 6.117336e-01 0.213
R-HSA-449147 Signaling by Interleukins 6.140947e-01 0.212
R-HSA-9833110 RSV-host interactions 6.149261e-01 0.211
R-HSA-3247509 Chromatin modifying enzymes 6.179920e-01 0.209
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 6.180926e-01 0.209
R-HSA-5696398 Nucleotide Excision Repair 6.180926e-01 0.209
R-HSA-9692914 SARS-CoV-1-host interactions 6.212332e-01 0.207
R-HSA-418346 Platelet homeostasis 6.212332e-01 0.207
R-HSA-15869 Metabolism of nucleotides 6.222618e-01 0.206
R-HSA-69239 Synthesis of DNA 6.243482e-01 0.205
R-HSA-211000 Gene Silencing by RNA 6.243482e-01 0.205
R-HSA-202733 Cell surface interactions at the vascular wall 6.243829e-01 0.205
R-HSA-1236975 Antigen processing-Cross presentation 6.274377e-01 0.202
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 6.274377e-01 0.202
R-HSA-69002 DNA Replication Pre-Initiation 6.305021e-01 0.200
R-HSA-975155 MyD88 dependent cascade initiated on endosome 6.305021e-01 0.200
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 6.335414e-01 0.198
R-HSA-166166 MyD88-independent TLR4 cascade 6.335414e-01 0.198
R-HSA-2871796 FCERI mediated MAPK activation 6.395458e-01 0.194
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 6.425113e-01 0.192
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... 6.483698e-01 0.188
R-HSA-4839726 Chromatin organization 6.491269e-01 0.188
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 6.512632e-01 0.186
R-HSA-421270 Cell-cell junction organization 6.531242e-01 0.185
R-HSA-2871809 FCERI mediated Ca+2 mobilization 6.541330e-01 0.184
R-HSA-2029485 Role of phospholipids in phagocytosis 6.541330e-01 0.184
R-HSA-2219528 PI3K/AKT Signaling in Cancer 6.626025e-01 0.179
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 6.653797e-01 0.177
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 6.653797e-01 0.177
R-HSA-73886 Chromosome Maintenance 6.708662e-01 0.173
R-HSA-3371556 Cellular response to heat stress 6.708662e-01 0.173
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 6.735759e-01 0.172
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 6.735759e-01 0.172
R-HSA-162909 Host Interactions of HIV factors 6.789289e-01 0.168
R-HSA-69206 G1/S Transition 6.841949e-01 0.165
R-HSA-9664323 FCGR3A-mediated IL10 synthesis 6.867956e-01 0.163
R-HSA-199418 Negative regulation of the PI3K/AKT network 6.969878e-01 0.157
R-HSA-9679506 SARS-CoV Infections 6.985996e-01 0.156
R-HSA-5576891 Cardiac conduction 7.019597e-01 0.154
R-HSA-72766 Translation 7.167256e-01 0.145
R-HSA-5173105 O-linked glycosylation 7.187323e-01 0.143
R-HSA-9018678 Biosynthesis of specialized proresolving mediators (SPMs) 7.345678e-01 0.134
R-HSA-195721 Signaling by WNT 7.369860e-01 0.133
R-HSA-453279 Mitotic G1 phase and G1/S transition 7.410806e-01 0.130
R-HSA-69242 S Phase 7.453340e-01 0.128
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 7.453340e-01 0.128
R-HSA-2173782 Binding and Uptake of Ligands by Scavenger Receptors 7.495181e-01 0.125
R-HSA-9856651 MITF-M-dependent gene expression 7.495181e-01 0.125
R-HSA-9679191 Potential therapeutics for SARS 7.495181e-01 0.125
R-HSA-9755511 KEAP1-NFE2L2 pathway 7.515845e-01 0.124
R-HSA-212436 Generic Transcription Pathway 7.522380e-01 0.124
R-HSA-2142753 Arachidonate metabolism 7.536340e-01 0.123
R-HSA-9609507 Protein localization 7.556667e-01 0.122
R-HSA-9006936 Signaling by TGFB family members 7.694370e-01 0.114
R-HSA-5619102 SLC transporter disorders 7.824368e-01 0.107
R-HSA-1474244 Extracellular matrix organization 7.850883e-01 0.105
R-HSA-72306 tRNA processing 7.895359e-01 0.103
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection 7.947089e-01 0.100
R-HSA-9664433 Leishmania parasite growth and survival 7.947089e-01 0.100
R-HSA-1428517 Aerobic respiration and respiratory electron transport 7.980707e-01 0.098
R-HSA-611105 Respiratory electron transport 8.030516e-01 0.095
R-HSA-201681 TCF dependent signaling in response to WNT 8.110577e-01 0.091
R-HSA-3781865 Diseases of glycosylation 8.126198e-01 0.090
R-HSA-168898 Toll-like Receptor Cascades 8.232009e-01 0.084
R-HSA-382551 Transport of small molecules 8.361974e-01 0.078
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 8.399783e-01 0.076
R-HSA-1483206 Glycerophospholipid biosynthesis 8.399783e-01 0.076
R-HSA-983169 Class I MHC mediated antigen processing & presentation 8.463428e-01 0.072
R-HSA-397014 Muscle contraction 8.527451e-01 0.069
R-HSA-9824439 Bacterial Infection Pathways 8.531375e-01 0.069
R-HSA-9730414 MITF-M-regulated melanocyte development 8.539648e-01 0.069
R-HSA-425407 SLC-mediated transmembrane transport 8.596595e-01 0.066
R-HSA-9748784 Drug ADME 8.599144e-01 0.066
R-HSA-5619115 Disorders of transmembrane transporters 8.899707e-01 0.051
R-HSA-71291 Metabolism of amino acids and derivatives 8.987304e-01 0.046
R-HSA-9711123 Cellular response to chemical stress 9.076499e-01 0.042
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 9.178388e-01 0.037
R-HSA-212165 Epigenetic regulation of gene expression 9.416926e-01 0.026
R-HSA-418594 G alpha (i) signalling events 9.714438e-01 0.013
R-HSA-8978868 Fatty acid metabolism 9.714438e-01 0.013
R-HSA-5668914 Diseases of metabolism 9.758727e-01 0.011
R-HSA-388396 GPCR downstream signalling 9.987482e-01 0.001
R-HSA-556833 Metabolism of lipids 9.988077e-01 0.001
R-HSA-1430728 Metabolism 9.991564e-01 0.000
R-HSA-372790 Signaling by GPCR 9.993892e-01 0.000
R-HSA-9709957 Sensory Perception 9.997353e-01 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
CDC7CDC7 0.830 0.370 1 0.867
COTCOT 0.825 0.096 2 0.790
MOSMOS 0.818 0.269 1 0.822
BMPR1BBMPR1B 0.815 0.305 1 0.842
CLK3CLK3 0.812 0.099 1 0.704
PIM3PIM3 0.811 0.058 -3 0.707
GRK1GRK1 0.811 0.169 -2 0.766
GCN2GCN2 0.807 -0.052 2 0.750
DSTYKDSTYK 0.806 0.007 2 0.795
NEK6NEK6 0.806 0.056 -2 0.889
NDR2NDR2 0.806 0.039 -3 0.718
PRPKPRPK 0.805 -0.041 -1 0.794
TGFBR2TGFBR2 0.805 0.081 -2 0.856
BMPR2BMPR2 0.803 0.060 -2 0.896
ULK2ULK2 0.803 -0.054 2 0.744
IKKBIKKB 0.802 -0.078 -2 0.737
RAF1RAF1 0.802 -0.041 1 0.725
NEK7NEK7 0.801 -0.011 -3 0.797
GRK5GRK5 0.801 0.038 -3 0.768
MST4MST4 0.801 0.059 2 0.822
MTORMTOR 0.801 -0.104 1 0.631
BMPR1ABMPR1A 0.801 0.300 1 0.852
RSK2RSK2 0.800 0.039 -3 0.640
FAM20CFAM20C 0.800 0.079 2 0.525
NLKNLK 0.800 0.009 1 0.651
TGFBR1TGFBR1 0.799 0.161 -2 0.853
ACVR2BACVR2B 0.799 0.217 -2 0.860
GRK6GRK6 0.799 0.088 1 0.780
GRK7GRK7 0.798 0.128 1 0.697
CAMK1BCAMK1B 0.798 -0.030 -3 0.728
ATRATR 0.798 -0.030 1 0.688
ACVR2AACVR2A 0.798 0.184 -2 0.851
ALK2ALK2 0.797 0.254 -2 0.847
CAMK2GCAMK2G 0.797 -0.074 2 0.707
TBK1TBK1 0.796 -0.114 1 0.601
PRKD1PRKD1 0.796 0.023 -3 0.686
PDHK4PDHK4 0.796 -0.214 1 0.707
SKMLCKSKMLCK 0.795 0.009 -2 0.850
ALK4ALK4 0.795 0.128 -2 0.867
ERK5ERK5 0.795 0.000 1 0.648
PDHK1PDHK1 0.795 -0.119 1 0.688
PIM1PIM1 0.794 0.032 -3 0.642
NDR1NDR1 0.794 -0.018 -3 0.696
KISKIS 0.794 -0.011 1 0.523
SRPK1SRPK1 0.794 0.017 -3 0.623
MAPKAPK2MAPKAPK2 0.794 0.040 -3 0.581
DAPK2DAPK2 0.794 0.036 -3 0.741
BCKDKBCKDK 0.794 -0.083 -1 0.771
CDKL1CDKL1 0.794 -0.023 -3 0.679
MARK4MARK4 0.793 0.019 4 0.871
IKKEIKKE 0.793 -0.118 1 0.600
NUAK2NUAK2 0.793 -0.013 -3 0.708
IKKAIKKA 0.793 -0.013 -2 0.736
WNK1WNK1 0.793 -0.029 -2 0.850
ATMATM 0.793 0.006 1 0.667
CAMLCKCAMLCK 0.792 0.002 -2 0.834
GRK4GRK4 0.792 -0.029 -2 0.838
AMPKA1AMPKA1 0.792 0.023 -3 0.714
MLK1MLK1 0.792 -0.078 2 0.761
AURCAURC 0.792 0.069 -2 0.639
PRKD2PRKD2 0.792 0.012 -3 0.628
NIKNIK 0.792 -0.050 -3 0.751
PKN3PKN3 0.792 -0.050 -3 0.690
ULK1ULK1 0.791 -0.109 -3 0.733
P90RSKP90RSK 0.791 -0.011 -3 0.641
CDKL5CDKL5 0.791 -0.003 -3 0.664
RIPK3RIPK3 0.790 -0.071 3 0.669
P70S6KBP70S6KB 0.790 0.004 -3 0.654
RSK3RSK3 0.790 -0.001 -3 0.635
MAPKAPK3MAPKAPK3 0.790 -0.015 -3 0.623
CHAK2CHAK2 0.789 -0.043 -1 0.736
HIPK4HIPK4 0.789 -0.007 1 0.616
PLK1PLK1 0.789 0.025 -2 0.861
LATS2LATS2 0.789 -0.024 -5 0.670
HUNKHUNK 0.789 -0.093 2 0.733
SRPK2SRPK2 0.789 0.014 -3 0.545
NEK9NEK9 0.788 -0.051 2 0.796
TSSK2TSSK2 0.788 0.038 -5 0.729
PKN2PKN2 0.788 -0.048 -3 0.698
PKCDPKCD 0.787 -0.015 2 0.732
TSSK1TSSK1 0.787 0.037 -3 0.735
CAMK2BCAMK2B 0.787 0.018 2 0.675
AMPKA2AMPKA2 0.787 0.015 -3 0.679
CAMK2DCAMK2D 0.786 -0.059 -3 0.698
CK2A2CK2A2 0.785 0.167 1 0.731
RSK4RSK4 0.785 0.035 -3 0.617
LATS1LATS1 0.784 0.044 -3 0.736
ANKRD3ANKRD3 0.784 -0.115 1 0.698
NIM1NIM1 0.784 -0.033 3 0.690
WNK3WNK3 0.784 -0.152 1 0.657
PKACGPKACG 0.784 -0.027 -2 0.711
SRPK3SRPK3 0.783 0.001 -3 0.603
MLK3MLK3 0.783 -0.035 2 0.693
IRE1IRE1 0.782 -0.069 1 0.631
MLK2MLK2 0.782 -0.085 2 0.776
SMG1SMG1 0.782 0.031 1 0.635
MNK2MNK2 0.782 -0.004 -2 0.781
CAMK2ACAMK2A 0.782 -0.004 2 0.678
TTBK2TTBK2 0.782 -0.120 2 0.649
PKRPKR 0.782 0.014 1 0.684
TLK2TLK2 0.781 -0.012 1 0.661
PAK1PAK1 0.781 -0.021 -2 0.773
DLKDLK 0.781 -0.159 1 0.702
ICKICK 0.780 -0.055 -3 0.709
CLK2CLK2 0.780 0.059 -3 0.607
MASTLMASTL 0.780 -0.226 -2 0.805
AURBAURB 0.780 0.033 -2 0.640
PLK3PLK3 0.779 -0.015 2 0.666
CDK8CDK8 0.779 -0.050 1 0.507
PKCBPKCB 0.779 -0.026 2 0.692
CDK1CDK1 0.779 -0.006 1 0.490
CLK1CLK1 0.779 0.017 -3 0.602
NEK2NEK2 0.779 -0.043 2 0.775
BRSK1BRSK1 0.779 -0.024 -3 0.647
QSKQSK 0.779 -0.000 4 0.849
CLK4CLK4 0.778 0.004 -3 0.629
PKACBPKACB 0.778 0.022 -2 0.664
CDK5CDK5 0.778 0.007 1 0.534
PAK3PAK3 0.778 -0.051 -2 0.770
MELKMELK 0.778 -0.029 -3 0.654
PKCAPKCA 0.778 -0.021 2 0.688
MLK4MLK4 0.777 -0.069 2 0.677
IRE2IRE2 0.777 -0.050 2 0.730
YSK4YSK4 0.777 -0.089 1 0.636
PKCGPKCG 0.777 -0.050 2 0.679
PRKD3PRKD3 0.776 -0.033 -3 0.608
PERKPERK 0.776 -0.008 -2 0.848
CDK7CDK7 0.776 -0.039 1 0.517
PKG2PKG2 0.776 0.012 -2 0.645
VRK2VRK2 0.776 -0.076 1 0.713
DYRK2DYRK2 0.776 -0.038 1 0.545
AURAAURA 0.776 0.020 -2 0.625
SIKSIK 0.775 -0.023 -3 0.622
MARK3MARK3 0.775 0.018 4 0.820
MSK2MSK2 0.775 -0.059 -3 0.610
GRK2GRK2 0.775 -0.025 -2 0.727
SGK3SGK3 0.775 -0.003 -3 0.624
PHKG1PHKG1 0.775 -0.075 -3 0.679
RIPK1RIPK1 0.775 -0.203 1 0.654
MEK1MEK1 0.775 -0.117 2 0.765
NUAK1NUAK1 0.774 -0.056 -3 0.643
QIKQIK 0.774 -0.081 -3 0.706
CK1ECK1E 0.774 -0.011 -3 0.523
CAMK4CAMK4 0.774 -0.114 -3 0.671
PAK6PAK6 0.774 0.005 -2 0.673
MNK1MNK1 0.774 -0.014 -2 0.786
MSK1MSK1 0.774 -0.016 -3 0.608
CK2A1CK2A1 0.774 0.134 1 0.703
CDK18CDK18 0.773 -0.017 1 0.448
MYLK4MYLK4 0.773 -0.020 -2 0.758
CDK19CDK19 0.773 -0.050 1 0.473
PIM2PIM2 0.773 0.007 -3 0.606
DCAMKL1DCAMKL1 0.773 -0.013 -3 0.645
AKT2AKT2 0.773 0.002 -3 0.557
CDK13CDK13 0.772 -0.046 1 0.489
DNAPKDNAPK 0.772 -0.046 1 0.570
CDK2CDK2 0.772 -0.017 1 0.561
JNK2JNK2 0.772 0.003 1 0.464
HRIHRI 0.772 -0.072 -2 0.878
DRAK1DRAK1 0.772 -0.060 1 0.678
PKCHPKCH 0.772 -0.061 2 0.683
PLK4PLK4 0.772 -0.069 2 0.593
BRAFBRAF 0.772 -0.002 -4 0.745
JNK3JNK3 0.772 -0.018 1 0.500
CDK3CDK3 0.771 0.027 1 0.431
PRKXPRKX 0.771 0.023 -3 0.551
BRSK2BRSK2 0.771 -0.066 -3 0.661
MARK2MARK2 0.771 -0.006 4 0.781
PAK2PAK2 0.771 -0.057 -2 0.754
CHAK1CHAK1 0.769 -0.120 2 0.725
P38GP38G 0.769 -0.021 1 0.404
TLK1TLK1 0.769 -0.082 -2 0.888
P38AP38A 0.768 -0.028 1 0.533
SSTKSSTK 0.768 0.045 4 0.842
CDK17CDK17 0.768 -0.031 1 0.410
PKCZPKCZ 0.768 -0.091 2 0.736
HIPK1HIPK1 0.768 -0.017 1 0.549
ERK1ERK1 0.767 -0.029 1 0.464
MST3MST3 0.767 -0.012 2 0.782
HIPK2HIPK2 0.767 -0.018 1 0.459
P38BP38B 0.767 -0.017 1 0.482
GRK3GRK3 0.767 -0.010 -2 0.691
NEK5NEK5 0.766 -0.053 1 0.667
ZAKZAK 0.766 -0.109 1 0.639
CHK1CHK1 0.766 -0.068 -3 0.684
PRP4PRP4 0.766 -0.014 -3 0.684
MEKK2MEKK2 0.766 -0.098 2 0.763
EEF2KEEF2K 0.765 0.090 3 0.799
MARK1MARK1 0.765 -0.037 4 0.832
CDK12CDK12 0.765 -0.051 1 0.463
CK1G1CK1G1 0.765 -0.052 -3 0.514
MEKK3MEKK3 0.765 -0.166 1 0.656
CDK16CDK16 0.764 0.000 1 0.424
SNRKSNRK 0.764 -0.145 2 0.646
TAO3TAO3 0.763 -0.058 1 0.641
P70S6KP70S6K 0.763 -0.025 -3 0.568
MEKK1MEKK1 0.762 -0.154 1 0.653
CK1DCK1D 0.762 -0.023 -3 0.472
DAPK3DAPK3 0.762 0.029 -3 0.658
MEK5MEK5 0.762 -0.217 2 0.770
WNK4WNK4 0.762 -0.104 -2 0.838
PKACAPKACA 0.762 -0.002 -2 0.607
MPSK1MPSK1 0.761 0.007 1 0.606
CDK9CDK9 0.761 -0.069 1 0.494
AKT1AKT1 0.761 -0.001 -3 0.569
ERK2ERK2 0.761 -0.064 1 0.497
CAMK1GCAMK1G 0.761 -0.087 -3 0.615
PASKPASK 0.761 -0.044 -3 0.746
MAPKAPK5MAPKAPK5 0.760 -0.133 -3 0.574
IRAK4IRAK4 0.759 -0.102 1 0.635
GSK3AGSK3A 0.759 0.009 4 0.483
CK1A2CK1A2 0.759 -0.034 -3 0.471
SMMLCKSMMLCK 0.759 -0.063 -3 0.678
DYRK1ADYRK1A 0.759 -0.053 1 0.559
GSK3BGSK3B 0.758 -0.007 4 0.475
PINK1PINK1 0.758 -0.158 1 0.639
PKCTPKCT 0.758 -0.074 2 0.696
TAO2TAO2 0.757 -0.056 2 0.788
CDK14CDK14 0.757 -0.035 1 0.484
MST2MST2 0.757 -0.053 1 0.678
PHKG2PHKG2 0.757 -0.083 -3 0.648
CDK10CDK10 0.757 -0.016 1 0.472
DCAMKL2DCAMKL2 0.757 -0.085 -3 0.663
GAKGAK 0.757 -0.024 1 0.694
NEK8NEK8 0.756 -0.121 2 0.770
TTBK1TTBK1 0.756 -0.137 2 0.566
TNIKTNIK 0.756 0.018 3 0.803
DAPK1DAPK1 0.756 0.014 -3 0.646
P38DP38D 0.756 -0.021 1 0.418
DYRK4DYRK4 0.755 -0.049 1 0.480
PLK2PLK2 0.755 0.004 -3 0.746
ERK7ERK7 0.754 -0.005 2 0.513
CAMKK1CAMKK1 0.754 -0.119 -2 0.718
DYRK1BDYRK1B 0.754 -0.055 1 0.503
AKT3AKT3 0.754 0.010 -3 0.498
PKCEPKCE 0.754 -0.026 2 0.674
HIPK3HIPK3 0.754 -0.065 1 0.532
CAMKK2CAMKK2 0.754 -0.090 -2 0.707
PAK5PAK5 0.754 -0.039 -2 0.636
HGKHGK 0.753 -0.022 3 0.791
GCKGCK 0.753 -0.060 1 0.661
CAMK1DCAMK1D 0.753 -0.048 -3 0.532
TAK1TAK1 0.753 -0.040 1 0.692
PKCIPKCI 0.752 -0.072 2 0.708
JNK1JNK1 0.752 -0.029 1 0.464
MINKMINK 0.752 -0.039 1 0.639
DYRK3DYRK3 0.752 -0.051 1 0.553
PAK4PAK4 0.751 -0.031 -2 0.643
SGK1SGK1 0.751 -0.002 -3 0.478
NEK11NEK11 0.750 -0.195 1 0.640
MEKK6MEKK6 0.750 -0.083 1 0.645
LKB1LKB1 0.749 -0.102 -3 0.739
MAKMAK 0.749 0.015 -2 0.690
NEK4NEK4 0.749 -0.105 1 0.626
PDK1PDK1 0.749 -0.125 1 0.642
MRCKAMRCKA 0.748 0.005 -3 0.601
HPK1HPK1 0.748 -0.055 1 0.641
MRCKBMRCKB 0.747 0.005 -3 0.590
CDK6CDK6 0.747 -0.022 1 0.459
MAP3K15MAP3K15 0.747 -0.107 1 0.613
VRK1VRK1 0.747 -0.086 2 0.779
NEK1NEK1 0.747 -0.050 1 0.635
ROCK2ROCK2 0.747 0.009 -3 0.640
KHS2KHS2 0.745 -0.005 1 0.638
LOKLOK 0.745 -0.063 -2 0.750
KHS1KHS1 0.745 -0.024 1 0.629
IRAK1IRAK1 0.745 -0.239 -1 0.710
MST1MST1 0.745 -0.109 1 0.645
PKN1PKN1 0.744 -0.073 -3 0.579
LRRK2LRRK2 0.744 -0.146 2 0.789
OSR1OSR1 0.743 -0.022 2 0.765
BUB1BUB1 0.743 0.027 -5 0.649
TTKTTK 0.743 0.025 -2 0.881
PDHK3_TYRPDHK3_TYR 0.742 0.129 4 0.895
YSK1YSK1 0.742 -0.056 2 0.779
CDK4CDK4 0.742 -0.038 1 0.450
MEK2MEK2 0.741 -0.129 2 0.762
CAMK1ACAMK1A 0.741 -0.050 -3 0.512
MOKMOK 0.741 -0.012 1 0.565
EPHA6EPHA6 0.739 0.178 -1 0.838
PBKPBK 0.739 -0.034 1 0.619
CHK2CHK2 0.739 -0.075 -3 0.494
STK33STK33 0.738 -0.156 2 0.554
SBKSBK 0.738 -0.032 -3 0.436
SLKSLK 0.736 -0.121 -2 0.707
EPHB4EPHB4 0.735 0.139 -1 0.838
DMPK1DMPK1 0.734 -0.005 -3 0.615
RIPK2RIPK2 0.733 -0.223 1 0.593
TESK1_TYRTESK1_TYR 0.733 -0.039 3 0.803
TXKTXK 0.733 0.175 1 0.783
MAP2K4_TYRMAP2K4_TYR 0.733 -0.005 -1 0.820
ROCK1ROCK1 0.733 -0.013 -3 0.599
CRIKCRIK 0.732 0.001 -3 0.570
NEK3NEK3 0.731 -0.110 1 0.590
ALPHAK3ALPHAK3 0.731 0.049 -1 0.719
PDHK4_TYRPDHK4_TYR 0.731 -0.021 2 0.789
MAP2K6_TYRMAP2K6_TYR 0.731 -0.044 -1 0.813
PKG1PKG1 0.730 -0.050 -2 0.579
MYO3BMYO3B 0.730 -0.043 2 0.788
BMPR2_TYRBMPR2_TYR 0.730 -0.046 -1 0.821
PKMYT1_TYRPKMYT1_TYR 0.729 -0.057 3 0.769
BIKEBIKE 0.729 -0.013 1 0.581
PDHK1_TYRPDHK1_TYR 0.729 -0.058 -1 0.825
CK1ACK1A 0.729 -0.054 -3 0.398
MAP2K7_TYRMAP2K7_TYR 0.728 -0.171 2 0.783
BLKBLK 0.727 0.144 -1 0.817
MYO3AMYO3A 0.727 -0.068 1 0.623
HASPINHASPIN 0.726 -0.074 -1 0.577
SRMSSRMS 0.726 0.130 1 0.807
HCKHCK 0.726 0.093 -1 0.823
PINK1_TYRPINK1_TYR 0.726 -0.173 1 0.690
EPHB2EPHB2 0.726 0.145 -1 0.827
LCKLCK 0.725 0.110 -1 0.818
ASK1ASK1 0.725 -0.130 1 0.607
EPHB1EPHB1 0.725 0.106 1 0.793
LIMK2_TYRLIMK2_TYR 0.725 -0.034 -3 0.766
EPHA4EPHA4 0.725 0.106 2 0.658
TAO1TAO1 0.725 -0.096 1 0.569
YES1YES1 0.724 0.035 -1 0.807
TYRO3TYRO3 0.724 0.018 3 0.700
ABL2ABL2 0.724 0.025 -1 0.780
FERFER 0.724 0.058 1 0.810
EPHB3EPHB3 0.724 0.115 -1 0.835
YANK3YANK3 0.723 -0.080 2 0.342
ROS1ROS1 0.722 -0.012 3 0.665
RETRET 0.721 -0.117 1 0.644
ABL1ABL1 0.721 0.019 -1 0.775
TECTEC 0.721 0.105 -1 0.764
TYK2TYK2 0.721 -0.124 1 0.650
EPHA7EPHA7 0.720 0.110 2 0.671
MST1RMST1R 0.720 -0.098 3 0.718
FGRFGR 0.719 -0.065 1 0.718
MERTKMERTK 0.719 0.077 3 0.674
ITKITK 0.719 0.042 -1 0.802
BMXBMX 0.719 0.060 -1 0.738
STLK3STLK3 0.718 -0.135 1 0.602
FYNFYN 0.718 0.067 -1 0.789
CSF1RCSF1R 0.717 -0.077 3 0.696
TNK2TNK2 0.717 0.014 3 0.667
LIMK1_TYRLIMK1_TYR 0.717 -0.174 2 0.795
JAK2JAK2 0.717 -0.121 1 0.640
DDR1DDR1 0.716 -0.124 4 0.840
FRKFRK 0.716 0.083 -1 0.837
TNNI3K_TYRTNNI3K_TYR 0.714 -0.023 1 0.650
BTKBTK 0.713 0.009 -1 0.782
INSRRINSRR 0.713 -0.079 3 0.643
AAK1AAK1 0.713 0.012 1 0.483
JAK3JAK3 0.713 -0.125 1 0.641
EPHA1EPHA1 0.713 0.059 3 0.662
EPHA5EPHA5 0.713 0.092 2 0.645
AXLAXL 0.712 -0.012 3 0.676
PTK6PTK6 0.712 -0.032 -1 0.721
EPHA3EPHA3 0.711 -0.014 2 0.642
LTKLTK 0.710 -0.017 3 0.639
LYNLYN 0.710 0.033 3 0.632
JAK1JAK1 0.710 -0.060 1 0.595
TEKTEK 0.709 -0.024 3 0.633
WEE1_TYRWEE1_TYR 0.709 -0.065 -1 0.721
PTK2BPTK2B 0.709 0.036 -1 0.772
KITKIT 0.709 -0.130 3 0.702
KDRKDR 0.709 -0.110 3 0.662
ALKALK 0.709 -0.033 3 0.608
FGFR2FGFR2 0.708 -0.140 3 0.699
CK1G3CK1G3 0.708 -0.064 -3 0.359
PDGFRBPDGFRB 0.708 -0.159 3 0.707
FLT3FLT3 0.708 -0.121 3 0.696
EPHA8EPHA8 0.707 0.017 -1 0.810
METMET 0.706 -0.095 3 0.682
SYKSYK 0.706 0.080 -1 0.756
NEK10_TYRNEK10_TYR 0.706 -0.107 1 0.520
SRCSRC 0.704 -0.016 -1 0.784
FGFR1FGFR1 0.702 -0.149 3 0.667
ERBB2ERBB2 0.702 -0.131 1 0.647
PDGFRAPDGFRA 0.702 -0.176 3 0.710
TNK1TNK1 0.702 -0.129 3 0.677
NTRK1NTRK1 0.701 -0.154 -1 0.783
PTK2PTK2 0.700 0.006 -1 0.770
FLT1FLT1 0.700 -0.147 -1 0.796
NTRK2NTRK2 0.699 -0.157 3 0.659
INSRINSR 0.698 -0.133 3 0.626
FGFR3FGFR3 0.698 -0.148 3 0.673
EGFREGFR 0.698 -0.072 1 0.574
EPHA2EPHA2 0.697 0.015 -1 0.793
NTRK3NTRK3 0.697 -0.122 -1 0.742
MATKMATK 0.696 -0.107 -1 0.680
DDR2DDR2 0.695 -0.087 3 0.637
FLT4FLT4 0.694 -0.191 3 0.665
CSKCSK 0.692 -0.124 2 0.678
YANK2YANK2 0.691 -0.100 2 0.354
ERBB4ERBB4 0.690 -0.041 1 0.635
MUSKMUSK 0.690 -0.100 1 0.558
CK1G2CK1G2 0.689 -0.067 -3 0.442
FGFR4FGFR4 0.688 -0.122 -1 0.743
IGF1RIGF1R 0.684 -0.131 3 0.563
FESFES 0.684 -0.034 -1 0.706
ZAP70ZAP70 0.671 -0.070 -1 0.673