Motif 870 (n=111)
Position-wise Probabilities
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uniprot | genes | site | source | protein | function |
---|---|---|---|---|---|
A0A0B4J269 | None | S462 | ochoa | Melanocyte-stimulating hormone receptor (Melanocortin receptor 1) | Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes. {ECO:0000256|ARBA:ARBA00023428}. |
A2RU67 | FAM234B | S75 | ochoa | Protein FAM234B | None |
E9PAV3 | NACA | S1995 | ochoa | Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC) | Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250|UniProtKB:P70670}. |
H3BQZ7 | HNRNPUL2-BSCL2 | S193 | ochoa | Heterogeneous nuclear ribonucleoprotein U-like protein 2 | None |
O00411 | POLRMT | S1184 | ochoa | DNA-directed RNA polymerase, mitochondrial (MtRPOL) (EC 2.7.7.6) | DNA-dependent RNA polymerase catalyzes the transcription of mitochondrial DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:21278163, PubMed:33602924). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA (PubMed:29149603). In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand (PubMed:29149603). Has DNA primase activity (PubMed:18685103, PubMed:33602924). Catalyzes the synthesis of short RNA primers that are necessary for the initiation of lagging-strand DNA synthesis from the origin of light-strand DNA replication (OriL) (PubMed:18685103, PubMed:33602924). {ECO:0000269|PubMed:18685103, ECO:0000269|PubMed:21278163, ECO:0000269|PubMed:29149603, ECO:0000269|PubMed:33602924}. |
O15020 | SPTBN2 | S1964 | ochoa | Spectrin beta chain, non-erythrocytic 2 (Beta-III spectrin) (Spinocerebellar ataxia 5 protein) | Probably plays an important role in neuronal membrane skeleton. |
O15240 | VGF | S65 | ochoa | Neurosecretory protein VGF [Cleaved into: Neuroendocrine regulatory peptide-1 (NERP-1); Neuroendocrine regulatory peptide-2 (NERP-2); VGF-derived peptide TLQP-21; VGF-derived peptide TLQP-62; Antimicrobial peptide VGF[554-577]] | [Neurosecretory protein VGF]: Secreted polyprotein that is packaged and proteolytically processed by prohormone convertases PCSK1 and PCSK2 in a cell-type-specific manner (By similarity). VGF and peptides derived from its processing play many roles in neurogenesis and neuroplasticity associated with learning, memory, depression and chronic pain (By similarity). {ECO:0000250|UniProtKB:P20156, ECO:0000250|UniProtKB:Q0VGU4}.; FUNCTION: [Neuroendocrine regulatory peptide-1]: Plays a role in the control of body fluid homeostasis by regulating vasopressin release. Suppresses presynaptic glutamatergic neurons connected to vasopressin neurons. {ECO:0000250|UniProtKB:P20156}.; FUNCTION: [Neuroendocrine regulatory peptide-2]: Plays a role in the control of body fluid homeostasis by regulating vasopressin release. Activates GABAergic interneurons which are inhibitory neurons of the nervous system and thereby suppresses presynaptic glutamatergic neurons (By similarity). Also stimulates feeding behavior in an orexin-dependent manner in the hypothalamus (By similarity). Functions as a positive regulator for the activation of orexin neurons resulting in elevated gastric acid secretion and gastric emptying (By similarity). {ECO:0000250|UniProtKB:P20156}.; FUNCTION: [VGF-derived peptide TLQP-21]: Secreted multifunctional neuropeptide that binds to different cell receptors and thereby plays multiple physiological roles including modulation of energy expenditure, pain, response to stress, gastric regulation, glucose homeostasis as well as lipolysis (By similarity). Activates the G-protein-coupled receptor C3AR1 via a folding-upon-binding mechanism leading to enhanced lipolysis in adipocytes (By similarity). Interacts with C1QBP receptor in macrophages and microglia causing increased levels of intracellular calcium and hypersensitivity (By similarity). {ECO:0000250|UniProtKB:P20156, ECO:0000250|UniProtKB:Q0VGU4}.; FUNCTION: [VGF-derived peptide TLQP-62]: Plays a role in the regulation of memory formation and depression-related behaviors potentially by influencing synaptic plasticity and neurogenesis. Induces acute and transient activation of the NTRK2/TRKB receptor and subsequent CREB phosphorylation (By similarity). Also induces insulin secretion in insulinoma cells by increasing intracellular calcium mobilization (By similarity). {ECO:0000250|UniProtKB:Q0VGU4}.; FUNCTION: [Antimicrobial peptide VGF[554-577]]: Has bactericidal activity against M.luteus, and antifungal activity against P. Pastoris. {ECO:0000269|PubMed:23250050}. |
O15439 | ABCC4 | S687 | ochoa | ATP-binding cassette sub-family C member 4 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (MRP/cMOAT-related ABC transporter) (Multi-specific organic anion transporter B) (MOAT-B) (Multidrug resistance-associated protein 4) | ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12523936, PubMed:12835412, PubMed:12883481, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12523936, PubMed:12883481, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:17344354, PubMed:18300232). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). {ECO:0000269|PubMed:11106685, ECO:0000269|PubMed:11856762, ECO:0000269|PubMed:12105214, ECO:0000269|PubMed:12523936, ECO:0000269|PubMed:12835412, ECO:0000269|PubMed:12883481, ECO:0000269|PubMed:15364914, ECO:0000269|PubMed:15454390, ECO:0000269|PubMed:16282361, ECO:0000269|PubMed:17344354, ECO:0000269|PubMed:17959747, ECO:0000269|PubMed:18300232, ECO:0000269|PubMed:26721430}. |
O43390 | HNRNPR | S228 | ochoa | Heterogeneous nuclear ribonucleoprotein R (hnRNP R) | Component of ribonucleosomes, which are complexes of at least 20 other different heterogeneous nuclear ribonucleoproteins (hnRNP). hnRNP play an important role in processing of precursor mRNA in the nucleus. |
O60496 | DOK2 | S77 | ochoa | Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2)) | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity). {ECO:0000250}. |
O60832 | DKC1 | S422 | ochoa | H/ACA ribonucleoprotein complex subunit DKC1 (EC 5.4.99.-) (CBF5 homolog) (Dyskerin) (Nopp140-associated protein of 57 kDa) (Nucleolar protein NAP57) (Nucleolar protein family A member 4) (snoRNP protein DKC1) | [Isoform 1]: Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA (PubMed:25219674, PubMed:32554502). This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1 (PubMed:25219674). Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance (PubMed:19179534, PubMed:25219674). Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme (PubMed:19179534). {ECO:0000269|PubMed:19179534, ECO:0000269|PubMed:25219674, ECO:0000269|PubMed:32554502}.; FUNCTION: [Isoform 3]: Promotes cell to cell and cell to substratum adhesion, increases the cell proliferation rate and leads to cytokeratin hyper-expression. {ECO:0000269|PubMed:21820037}. |
O60936 | NOL3 | S142 | ochoa | Nucleolar protein 3 (Apoptosis repressor with CARD) (Muscle-enriched cytoplasmic protein) (Myp) (Nucleolar protein of 30 kDa) (Nop30) | [Isoform 1]: May be involved in RNA splicing. {ECO:0000269|PubMed:10196175}.; FUNCTION: [Isoform 2]: Functions as an apoptosis repressor that blocks multiple modes of cell death. Inhibits extrinsic apoptotic pathways through two different ways. Firstly by interacting with FAS and FADD upon FAS activation blocking death-inducing signaling complex (DISC) assembly (By similarity). Secondly by interacting with CASP8 in a mitochondria localization- and phosphorylation-dependent manner, limiting the amount of soluble CASP8 available for DISC-mediated activation (By similarity). Inhibits intrinsic apoptotic pathway in response to a wide range of stresses, through its interaction with BAX resulting in BAX inactivation, preventing mitochondrial dysfunction and release of pro-apoptotic factors (PubMed:15004034). Inhibits calcium-mediated cell death by functioning as a cytosolic calcium buffer, dissociating its interaction with CASP8 and maintaining calcium homeostasis (PubMed:15509781). Negatively regulates oxidative stress-induced apoptosis by phosphorylation-dependent suppression of the mitochondria-mediated intrinsic pathway, by blocking CASP2 activation and BAX translocation (By similarity). Negatively regulates hypoxia-induced apoptosis in part by inhibiting the release of cytochrome c from mitochondria in a caspase-independent manner (By similarity). Also inhibits TNF-induced necrosis by preventing TNF-signaling pathway through TNFRSF1A interaction abrogating the recruitment of RIPK1 to complex I (By similarity). Finally through its role as apoptosis repressor, promotes vascular remodeling through inhibition of apoptosis and stimulation of proliferation, in response to hypoxia (By similarity). Inhibits too myoblast differentiation through caspase inhibition (By similarity). {ECO:0000250|UniProtKB:Q62881, ECO:0000250|UniProtKB:Q9D1X0, ECO:0000269|PubMed:15004034, ECO:0000269|PubMed:15509781}. |
O75582 | RPS6KA5 | S368 | ochoa | Ribosomal protein S6 kinase alpha-5 (S6K-alpha-5) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 5) (Nuclear mitogen- and stress-activated protein kinase 1) (RSK-like protein kinase) (RSKL) | Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes (PubMed:11909979, PubMed:12569367, PubMed:12763138, PubMed:18511904, PubMed:9687510, PubMed:9873047). Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin (PubMed:11909979, PubMed:9873047). Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression (PubMed:12628924, PubMed:18511904). In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress (PubMed:12628924). In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential (PubMed:12763138). Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation (PubMed:12569367). Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A (PubMed:15010469). Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN (PubMed:12773393). May also phosphorylate 'Ser-28' of histone H3 (PubMed:12773393). Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14) (PubMed:12773393). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines (By similarity). Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors (By similarity). Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury (By similarity). Phosphorylates TRIM7 at 'Ser-107' in response to growth factor signaling via the MEK/ERK pathway, thereby stimulating its ubiquitin ligase activity (PubMed:25851810). {ECO:0000250|UniProtKB:Q8C050, ECO:0000269|PubMed:11909979, ECO:0000269|PubMed:12569367, ECO:0000269|PubMed:12628924, ECO:0000269|PubMed:12763138, ECO:0000269|PubMed:12773393, ECO:0000269|PubMed:15010469, ECO:0000269|PubMed:18511904, ECO:0000269|PubMed:25851810, ECO:0000269|PubMed:9687510, ECO:0000269|PubMed:9873047}. |
O75943 | RAD17 | S86 | ochoa | Cell cycle checkpoint protein RAD17 (hRad17) (RF-C/activator 1 homolog) | Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage (PubMed:10208430, PubMed:11418864, PubMed:11687627, PubMed:11799063, PubMed:12672690, PubMed:14624239, PubMed:15235112). Has a weak ATPase activity required for binding to chromatin (PubMed:10208430, PubMed:11418864, PubMed:11687627, PubMed:11799063, PubMed:12672690, PubMed:14624239, PubMed:15235112). Participates in the recruitment of the 9-1-1 (RAD1-RAD9-HUS1) complex and RHNO1 onto chromatin, and in CHEK1 activation (PubMed:21659603). Involved in homologous recombination by mediating recruitment of the MRN complex to DNA damage sites (PubMed:24534091). May also serve as a sensor of DNA replication progression (PubMed:12578958, PubMed:14500819, PubMed:15538388). {ECO:0000269|PubMed:10208430, ECO:0000269|PubMed:11418864, ECO:0000269|PubMed:11687627, ECO:0000269|PubMed:11799063, ECO:0000269|PubMed:12578958, ECO:0000269|PubMed:12672690, ECO:0000269|PubMed:14500819, ECO:0000269|PubMed:14624239, ECO:0000269|PubMed:15235112, ECO:0000269|PubMed:15538388, ECO:0000269|PubMed:21659603, ECO:0000269|PubMed:24534091}. |
O94804 | STK10 | S455 | ochoa | Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase) | Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. {ECO:0000269|PubMed:11903060, ECO:0000269|PubMed:12639966, ECO:0000269|PubMed:19255442}. |
O94887 | FARP2 | S886 | ochoa | FERM, ARHGEF and pleckstrin domain-containing protein 2 (FERM domain-including RhoGEF) (FIR) (FERM, RhoGEF and pleckstrin domain-containing protein 2) (Pleckstrin homology domain-containing family C member 3) (PH domain-containing family C member 3) | Functions as a guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity). {ECO:0000250}. |
P06744 | GPI | S176 | ochoa | Glucose-6-phosphate isomerase (GPI) (EC 5.3.1.9) (Autocrine motility factor) (AMF) (Neuroleukin) (NLK) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI) (Sperm antigen 36) (SA-36) | In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis (PubMed:28803808). Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility (PubMed:11437381). Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons (PubMed:11004567, PubMed:3352745). It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion (PubMed:11004567, PubMed:3352745). {ECO:0000269|PubMed:11004567, ECO:0000269|PubMed:11437381, ECO:0000269|PubMed:28803808, ECO:0000269|PubMed:3352745}. |
P07437 | TUBB | S115 | ochoa | Tubulin beta chain (Tubulin beta-5 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
P08237 | PFKM | S74 | psp | ATP-dependent 6-phosphofructokinase, muscle type (ATP-PFK) (PFK-M) (EC 2.7.1.11) (6-phosphofructokinase type A) (Phosphofructo-1-kinase isozyme A) (PFK-A) (Phosphohexokinase) | Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. |
P18583 | SON | S1570 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
P19174 | PLCG1 | Y775 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1) | Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Plays a role in actin reorganization and cell migration (PubMed:17229814). Guanine nucleotide exchange factor that binds the GTPase DNM1 and catalyzes the dissociation of GDP, allowing a GTP molecule to bind in its place, therefore enhancing DNM1-dependent endocytosis (By similarity). {ECO:0000250|UniProtKB:P10686, ECO:0000269|PubMed:17229814, ECO:0000269|PubMed:37422272}. |
P19338 | NCL | S491 | ochoa | Nucleolin (Protein C23) | Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. {ECO:0000269|PubMed:10393184}. |
P21333 | FLNA | S310 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
P21796 | VDAC1 | S240 | ochoa | Non-selective voltage-gated ion channel VDAC1 (Outer mitochondrial membrane protein porin 1) (Plasmalemmal porin) (Porin 31HL) (Porin 31HM) (Voltage-dependent anion-selective channel protein 1) (VDAC-1) (hVDAC1) | Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane (PubMed:10661876, PubMed:11845315, PubMed:18755977, PubMed:30061676, PubMed:8420959). The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis (PubMed:10661876, PubMed:11845315, PubMed:18755977, PubMed:8420959). It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV (PubMed:10661876, PubMed:18755977, PubMed:8420959). The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:18755977, PubMed:8420959). Binds various signaling molecules, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterols cholesterol and oxysterol (PubMed:18755977, PubMed:31015432). In depolarized mitochondria, acts downstream of PRKN and PINK1 to promote mitophagy or prevent apoptosis; polyubiquitination by PRKN promotes mitophagy, while monoubiquitination by PRKN decreases mitochondrial calcium influx which ultimately inhibits apoptosis (PubMed:32047033). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (PubMed:15033708, PubMed:25296756). May mediate ATP export from cells (PubMed:30061676). Part of a complex composed of HSPA9, ITPR1 and VDAC1 that regulates mitochondrial calcium-dependent apoptosis by facilitating calcium transport from the ER lumen to the mitochondria intermembrane space thus providing calcium for the downstream calcium channel MCU that directly releases it into mitochondria matrix (By similarity). Mediates cytochrome c efflux (PubMed:20230784). {ECO:0000250|UniProtKB:Q60932, ECO:0000269|PubMed:10661876, ECO:0000269|PubMed:11845315, ECO:0000269|PubMed:15033708, ECO:0000269|PubMed:18755977, ECO:0000269|PubMed:20230784, ECO:0000269|PubMed:25296756, ECO:0000269|PubMed:30061676, ECO:0000269|PubMed:31015432, ECO:0000269|PubMed:32047033, ECO:0000269|PubMed:8420959}.; FUNCTION: Catalyzes the scrambling of phospholipids across the outer mitochondrial membrane; the mechanism is unrelated to channel activity and is capable of translocating both anionic and zwitterionic phospholipids. {ECO:0000269|PubMed:38065946}. |
P23246 | SFPQ | S283 | ochoa|psp | Splicing factor, proline- and glutamine-rich (100 kDa DNA-pairing protein) (hPOMp100) (DNA-binding p52/p100 complex, 100 kDa subunit) (Polypyrimidine tract-binding protein-associated-splicing factor) (PSF) (PTB-associated-splicing factor) | DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphorylation is proposed to lead to release from THRAP3 allowing binding to pre-mRNA splicing regulatotry elements which represses exon inclusion. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. May be involved in a pre-mRNA coupled splicing and polyadenylation process as component of a snRNP-free complex with SNRPA/U1A. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. SFPQ may be involved in homologous DNA pairing; in vitro, promotes the invasion of ssDNA between a duplex DNA and produces a D-loop formation. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1; in vitro, stimulates dissociation of TOP1 from DNA after cleavage and enhances its jumping between separate DNA helices. The SFPQ-NONO heteromer binds DNA (PubMed:25765647). The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends; in vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. SFPQ is involved in transcriptional regulation. Functions as a transcriptional activator (PubMed:25765647). Transcriptional repression is mediated by an interaction of SFPQ with SIN3A and subsequent recruitment of histone deacetylases (HDACs). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. SFPQ isoform Long binds to the DNA binding domains (DBD) of nuclear hormone receptors, like RXRA and probably THRA, and acts as a transcriptional corepressor in absence of hormone ligands. Binds the DNA sequence 5'-CTGAGTC-3' in the insulin-like growth factor response element (IGFRE) and inhibits IGF1-stimulated transcriptional activity. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation (By similarity). Required for the assembly of nuclear speckles (PubMed:25765647). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000250|UniProtKB:Q8VIJ6, ECO:0000269|PubMed:10847580, ECO:0000269|PubMed:10858305, ECO:0000269|PubMed:10931916, ECO:0000269|PubMed:11259580, ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:11897684, ECO:0000269|PubMed:15590677, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:25765647, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:8045264, ECO:0000269|PubMed:8449401}. |
P25205 | MCM3 | S740 | ochoa | DNA replication licensing factor MCM3 (EC 3.6.4.12) (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3) (RLF subunit beta) (p102) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for the entry in S phase and for cell division (Probable). {ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000305|PubMed:35585232}. |
P26583 | HMGB2 | S115 | ochoa | High mobility group protein B2 (High mobility group protein 2) (HMG-2) | Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes. Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:11909973, PubMed:18413230, PubMed:19522541, PubMed:19965638, PubMed:20123072, PubMed:7797075). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a promiscuous immunogenic DNA/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). In the extracellular compartment acts as a chemokine. Promotes proliferation and migration of endothelial cells implicating AGER/RAGE (PubMed:19811285). Has antimicrobial activity in gastrointestinal epithelial tissues (PubMed:23877675). Involved in inflammatory response to antigenic stimulus coupled with pro-inflammatory activity (By similarity). Involved in modulation of neurogenesis probably by regulation of neural stem proliferation (By similarity). Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway (By similarity). {ECO:0000250|UniProtKB:P09429, ECO:0000250|UniProtKB:P30681, ECO:0000269|PubMed:11909973, ECO:0000269|PubMed:18413230, ECO:0000269|PubMed:19522541, ECO:0000269|PubMed:19811285, ECO:0000269|PubMed:19965638, ECO:0000269|PubMed:23877675, ECO:0000269|PubMed:7797075, ECO:0000305|PubMed:20123072}. |
P31785 | IL2RG | S326 | ochoa | Cytokine receptor common subunit gamma (Interleukin-2 receptor subunit gamma) (IL-2 receptor subunit gamma) (IL-2R subunit gamma) (IL-2RG) (gammaC) (p64) (CD antigen CD132) | Common subunit for the receptors for a variety of interleukins. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (PubMed:15123770). {ECO:0000269|PubMed:15123770}. |
P45880 | VDAC2 | S251 | ochoa | Non-selective voltage-gated ion channel VDAC2 (VDAC-2) (hVDAC2) (Outer mitochondrial membrane protein porin 2) | Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane (PubMed:8420959). The channel adopts an open conformation at zero mV and a closed conformation at both positive and negative potentials (PubMed:8420959). There are two populations of channels; the main that functions in a lower open-state conductance with lower ion selectivity, that switch, in a voltage-dependent manner, from the open to a low-conducting 'closed' state and the other that has a normal ion selectivity in the typical high conductance, 'open' state (PubMed:8420959). Binds various lipids, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterols cholesterol and oxysterol (PubMed:31015432). Binding of ceramide promotes the mitochondrial outer membrane permeabilization (MOMP) apoptotic pathway (PubMed:31015432). {ECO:0000269|PubMed:31015432, ECO:0000269|PubMed:8420959}.; FUNCTION: Catalyzes the scrambling of phospholipids across the outer mitochondrial membrane; the mechanism is unrelated to channel activity and is capable of translocating both anionic and zwitterionic phospholipids. {ECO:0000269|PubMed:38065946}. |
P51608 | MECP2 | S65 | ochoa | Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2) | Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). {ECO:0000250|UniProtKB:Q9Z2D6}. |
P55011 | SLC12A2 | S132 | ochoa | Solute carrier family 12 member 2 (Basolateral Na-K-Cl symporter) (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2) (BSC2) (Na-K-2Cl cotransporter 1) (hNKCC1) | Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:33597714, PubMed:35585053, PubMed:36239040, PubMed:36306358, PubMed:7629105). Plays a vital role in the regulation of ionic balance and cell volume (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:7629105). {ECO:0000269|PubMed:16669787, ECO:0000269|PubMed:32081947, ECO:0000269|PubMed:32294086, ECO:0000269|PubMed:33597714, ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36239040, ECO:0000269|PubMed:36306358, ECO:0000269|PubMed:7629105}. |
P57103 | SLC8A3 | S382 | ochoa | Sodium/calcium exchanger 3 (Na(+)/Ca(2+)-exchange protein 3) (Solute carrier family 8 member 3) | Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells, both in muscle and in brain. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A3 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In neurons, contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory (By similarity). Required for normal oligodendrocyte differentiation and for normal myelination (PubMed:21959935). Mediates Ca(2+) efflux from mitochondria and contributes to mitochondrial Ca(2+) ion homeostasis (By similarity). {ECO:0000250|UniProtKB:S4R2P9, ECO:0000269|PubMed:21959935}. |
P60484 | PTEN | S380 | psp | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.16) (EC 3.1.3.48) (EC 3.1.3.67) (Inositol polyphosphate 3-phosphatase) (EC 3.1.3.-) (Mutated in multiple advanced cancers 1) (Phosphatase and tensin homolog) | Dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins (PubMed:9187108, PubMed:9256433, PubMed:9616126). Also functions as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring of PtdIns(3,4,5)P3/phosphatidylinositol 3,4,5-trisphosphate, PtdIns(3,4)P2/phosphatidylinositol 3,4-diphosphate and PtdIns3P/phosphatidylinositol 3-phosphate with a preference for PtdIns(3,4,5)P3 (PubMed:16824732, PubMed:26504226, PubMed:9593664, PubMed:9811831). Furthermore, this enzyme can also act as a cytosolic inositol 3-phosphatase acting on Ins(1,3,4,5,6)P5/inositol 1,3,4,5,6 pentakisphosphate and possibly Ins(1,3,4,5)P4/1D-myo-inositol 1,3,4,5-tetrakisphosphate (PubMed:11418101, PubMed:15979280). Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (PubMed:31492966, PubMed:37279284). The unphosphorylated form cooperates with MAGI2 to suppress AKT1 activation (PubMed:11707428). In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement (PubMed:22279049). Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation (PubMed:22279049). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces PTEN phosphorylation which changes its binding preference from the p85 regulatory subunit of the PI3K kinase complex to DLC1 and results in translocation of the PTEN-DLC1 complex to the posterior of migrating cells to promote RHOA activation (PubMed:26166433). Meanwhile, TNS3 switches binding preference from DLC1 to p85 and the TNS3-p85 complex translocates to the leading edge of migrating cells to activate RAC1 activation (PubMed:26166433). Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Involved in the regulation of synaptic function in excitatory hippocampal synapses. Recruited to the postsynaptic membrane upon NMDA receptor activation, is required for the modulation of synaptic activity during plasticity. Enhancement of lipid phosphatase activity is able to drive depression of AMPA receptor-mediated synaptic responses, activity required for NMDA receptor-dependent long-term depression (LTD) (By similarity). May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability (PubMed:10468583, PubMed:18716620). {ECO:0000250|UniProtKB:O08586, ECO:0000250|UniProtKB:O54857, ECO:0000269|PubMed:10468583, ECO:0000269|PubMed:11418101, ECO:0000269|PubMed:11707428, ECO:0000269|PubMed:15979280, ECO:0000269|PubMed:16824732, ECO:0000269|PubMed:18716620, ECO:0000269|PubMed:22279049, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26504226, ECO:0000269|PubMed:31492966, ECO:0000269|PubMed:37279284, ECO:0000269|PubMed:9187108, ECO:0000269|PubMed:9256433, ECO:0000269|PubMed:9593664, ECO:0000269|PubMed:9616126, ECO:0000269|PubMed:9811831}.; FUNCTION: [Isoform alpha]: Functional kinase, like isoform 1 it antagonizes the PI3K-AKT/PKB signaling pathway. Plays a role in mitochondrial energetic metabolism by promoting COX activity and ATP production, via collaboration with isoform 1 in increasing protein levels of PINK1. {ECO:0000269|PubMed:23744781}. |
P60709 | ACTB | S300 | ochoa | Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] | Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (PubMed:39321809, PubMed:38609661). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:Q6QAQ1, ECO:0000269|PubMed:25255767, ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
P62910 | RPL32 | S105 | ochoa | Large ribosomal subunit protein eL32 (60S ribosomal protein L32) | Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
P63261 | ACTG1 | S300 | ochoa | Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage (By similarity). {ECO:0000250|UniProtKB:P63260, ECO:0000305|PubMed:29581253}. |
P68371 | TUBB4B | S115 | ochoa | Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
P78527 | PRKDC | S2932 | ochoa | DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) | Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250|UniProtKB:P97313, ECO:0000269|PubMed:10026262, ECO:0000269|PubMed:10467406, ECO:0000269|PubMed:11889123, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12509254, ECO:0000269|PubMed:12649176, ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:14612514, ECO:0000269|PubMed:14627815, ECO:0000269|PubMed:14704337, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:15262962, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:1597196, ECO:0000269|PubMed:16046194, ECO:0000269|PubMed:16397295, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:2247066, ECO:0000269|PubMed:2507541, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30247612, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33854234, ECO:0000269|PubMed:34352203, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:8407951, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9362500, ECO:0000269|PubMed:9363941, ECO:0000269|PubMed:9679063}. |
P98171 | ARHGAP4 | S216 | ochoa | Rho GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (Rho-type GTPase-activating protein 4) (p115) | Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells. |
Q00536 | CDK16 | S65 | ochoa|psp | Cyclin-dependent kinase 16 (EC 2.7.11.22) (Cell division protein kinase 16) (PCTAIRE-motif protein kinase 1) (Serine/threonine-protein kinase PCTAIRE-1) | Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro). {ECO:0000250, ECO:0000269|PubMed:22184064, ECO:0000269|PubMed:22796189, ECO:0000269|PubMed:22798068}. |
Q01538 | MYT1 | S108 | ochoa | Myelin transcription factor 1 (MyT1) (Myelin transcription factor I) (MyTI) (PLPB1) (Proteolipid protein-binding protein) | Binds to the promoter region of genes encoding proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendroglia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription. {ECO:0000269|PubMed:14962745}. |
Q02556 | IRF8 | S232 | ochoa | Interferon regulatory factor 8 (IRF-8) (Interferon consensus sequence-binding protein) (H-ICSBP) (ICSBP) | Transcription factor that specifically binds to the upstream regulatory region of type I interferon (IFN) and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) (PubMed:25122610). Can both act as a transcriptional activator or repressor (By similarity). Plays a negative regulatory role in cells of the immune system (By similarity). Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes (By similarity). Required for the development of plasmacytoid dendritic cells (pDCs), which produce most of the type I IFN in response to viral infection (By similarity). Positively regulates macroautophagy in dendritic cells (PubMed:29434592). Acts as a transcriptional repressor of osteoclast differentiation factors such as NFATC1 and EEIG1 (By similarity). {ECO:0000250|UniProtKB:P23611, ECO:0000269|PubMed:25122610, ECO:0000269|PubMed:29434592}. |
Q04837 | SSBP1 | S70 | ochoa | Single-stranded DNA-binding protein, mitochondrial (Mt-SSB) (MtSSB) (PWP1-interacting protein 17) | Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA) (PubMed:21953457, PubMed:23290262, PubMed:31550240). In vitro, required to maintain the copy number of mitochondrial DNA (mtDNA) and plays a crucial role during mtDNA replication by stimulating the activity of the replisome components POLG and TWNK at the replication fork (PubMed:12975372, PubMed:15167897, PubMed:21953457, PubMed:26446790, PubMed:31550240). Promotes the activity of the gamma complex polymerase POLG, largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate POLG activity (PubMed:21953457, PubMed:26446790, PubMed:31550240). In addition it is able to promote the 5'-3' unwinding activity of the mtDNA helicase TWNK (PubMed:12975372). May also function in mtDNA repair (PubMed:23290262). {ECO:0000269|PubMed:12975372, ECO:0000269|PubMed:15167897, ECO:0000269|PubMed:21953457, ECO:0000269|PubMed:23290262, ECO:0000269|PubMed:26446790, ECO:0000269|PubMed:31550240}. |
Q09666 | AHNAK | S110 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
Q13509 | TUBB3 | S115 | ochoa | Tubulin beta-3 chain (Tubulin beta-4 chain) (Tubulin beta-III) | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:34996871, PubMed:38305685, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:34996871, PubMed:38305685, PubMed:38609661). Below the cap, alpha-beta tubulin heterodimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). TUBB3 plays a critical role in proper axon guidance and maintenance (PubMed:20074521). Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Plays a role in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). {ECO:0000269|PubMed:20074521, ECO:0000269|PubMed:28483977, ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
Q13885 | TUBB2A | S115 | ochoa | Tubulin beta-2A chain (Tubulin beta class IIa) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
Q14157 | UBAP2L | S254 | ochoa | Ubiquitin-associated protein 2-like (Protein NICE-4) (RNA polymerase II degradation factor UBAP2L) | Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs) (By similarity). Is a regulator of stress granule assembly, required for their efficient formation (PubMed:29395067, PubMed:35977029). Required for proper brain development and neocortex lamination (By similarity). {ECO:0000250|UniProtKB:Q80X50, ECO:0000269|PubMed:29395067, ECO:0000269|PubMed:35633597}. |
Q1KMD3 | HNRNPUL2 | S193 | ochoa | Heterogeneous nuclear ribonucleoprotein U-like protein 2 (Scaffold-attachment factor A2) (SAF-A2) | None |
Q5JTC6 | AMER1 | S42 | ochoa | APC membrane recruitment protein 1 (Amer1) (Protein FAM123B) (Wilms tumor gene on the X chromosome protein) | Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development. {ECO:0000269|PubMed:17510365, ECO:0000269|PubMed:17925383, ECO:0000269|PubMed:19416806, ECO:0000269|PubMed:21304492, ECO:0000269|PubMed:21498506}. |
Q6NWY9 | PRPF40B | S847 | ochoa | Pre-mRNA-processing factor 40 homolog B (Huntingtin yeast partner C) (Huntingtin-interacting protein C) | May be involved in pre-mRNA splicing. {ECO:0000269|PubMed:9700202}. |
Q6PJG2 | MIDEAS | S709 | ochoa | Mitotic deacetylase-associated SANT domain protein (ELM2 and SANT domain-containing protein 1) | None |
Q7L4E1 | MIGA2 | S224 | ochoa | Mitoguardin 2 (Protein FAM73B) | Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD. {ECO:0000269|PubMed:26711011}. |
Q7Z3K3 | POGZ | S721 | ochoa | Pogo transposable element with ZNF domain (Suppressor of hairy wing homolog 5) (Zinc finger protein 280E) (Zinc finger protein 635) | Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms (PubMed:20562864). Promotes the repair of DNA double-strand breaks through the homologous recombination pathway (PubMed:26721387). {ECO:0000269|PubMed:20562864, ECO:0000269|PubMed:26721387}. |
Q7Z434 | MAVS | S409 | ochoa | Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA) | Adapter required for innate immune defense against viruses (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:21170385, PubMed:23087404, PubMed:27992402, PubMed:33139700, PubMed:37582970). Acts downstream of DHX33, RIGI and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFNB and RANTES (CCL5) (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:20628368, PubMed:21170385, PubMed:23087404, PubMed:25636800, PubMed:27736772, PubMed:33110251). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state (PubMed:20451243). Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response (PubMed:20451243). May activate the same pathways following detection of extracellular dsRNA by TLR3 (PubMed:16153868). May protect cells from apoptosis (PubMed:16125763). Involved in NLRP3 inflammasome activation by mediating NLRP3 recruitment to mitochondria (PubMed:23582325). {ECO:0000269|PubMed:16125763, ECO:0000269|PubMed:16127453, ECO:0000269|PubMed:16153868, ECO:0000269|PubMed:16177806, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20451243, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:23087404, ECO:0000269|PubMed:23582325, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:27992402, ECO:0000269|PubMed:33110251, ECO:0000269|PubMed:33139700, ECO:0000269|PubMed:37582970}. |
Q86WR7 | PROSER2 | S311 | ochoa | Proline and serine-rich protein 2 | None |
Q8IV36 | HID1 | S616 | ochoa | Protein HID1 (Down-regulated in multiple cancers 1) (HID1 domain-containing protein) (Protein hid-1 homolog) | May play an important role in the development of cancers in a broad range of tissues. {ECO:0000269|PubMed:11281419}. |
Q8IVH2 | FOXP4 | S52 | ochoa | Forkhead box protein P4 (Fork head-related protein-like A) | Transcriptional repressor that represses lung-specific expression. {ECO:0000250}. |
Q8IXU6 | SLC35F2 | S24 | ochoa | Solute carrier family 35 member F2 | Putative solute transporter. {ECO:0000305}. |
Q8N1F7 | NUP93 | S168 | ochoa | Nuclear pore complex protein Nup93 (93 kDa nucleoporin) (Nucleoporin Nup93) | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling (PubMed:26878725). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:15703211, ECO:0000269|PubMed:26878725, ECO:0000269|PubMed:9348540}. |
Q8N2F6 | ARMC10 | S54 | ochoa | Armadillo repeat-containing protein 10 (Splicing variant involved in hepatocarcinogenesis protein) | May play a role in cell survival and cell growth. May suppress the transcriptional activity of p53/TP53. {ECO:0000269|PubMed:12839973, ECO:0000269|PubMed:17904127}. |
Q8N5U6 | RNF10 | S128 | ochoa | E3 ubiquitin-protein ligase RNF10 (EC 2.3.2.27) (RING finger protein 10) | E3 ubiquitin-protein ligase that catalyzes monoubiquitination of 40S ribosomal proteins RPS2/us5 and RPS3/us3 in response to ribosome stalling (PubMed:34348161, PubMed:34469731). Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC): RNF10 acts by mediating monoubiquitination of RPS2/us5 and RPS3/us3, promoting their degradation by the proteasome (PubMed:34348161, PubMed:34469731). Also promotes ubiquitination of 40S ribosomal proteins in response to ribosome stalling during translation elongation (PubMed:34348161). The action of RNF10 in iRQC is counteracted by USP10 (PubMed:34469731). May also act as a transcriptional factor involved in the regulation of MAG (Myelin-associated glycoprotein) expression (By similarity). Acts as a regulator of Schwann cell differentiation and myelination (By similarity). {ECO:0000250|UniProtKB:Q5XI59, ECO:0000269|PubMed:34348161, ECO:0000269|PubMed:34469731}. |
Q8NFQ8 | TOR1AIP2 | S167 | ochoa | Torsin-1A-interacting protein 2 (Lumenal domain-like LAP1) | Required for endoplasmic reticulum integrity. Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope as well as induces TOR1A, TOR1B and TOR3A ATPase activity. {ECO:0000269|PubMed:19339278, ECO:0000269|PubMed:23569223, ECO:0000269|PubMed:24275647}. |
Q8WUX9 | CHMP7 | S431 | ochoa | Charged multivesicular body protein 7 (Chromatin-modifying protein 7) | ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope (NE) during late anaphase (PubMed:26040712). Together with SPAST, the ESCRT-III complex promotes NE sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712, PubMed:28242692). Recruited to the reforming NE during anaphase by LEMD2 (PubMed:28242692). Plays a role in the endosomal sorting pathway (PubMed:16856878). {ECO:0000269|PubMed:16856878, ECO:0000269|PubMed:26040712, ECO:0000269|PubMed:28242692}. |
Q92599 | SEPTIN8 | S20 | ochoa | Septin-8 | Filament-forming cytoskeletal GTPase (By similarity). May play a role in platelet secretion (PubMed:15116257). Seems to participate in the process of SNARE complex formation in synaptic vesicles (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:B0BNF1, ECO:0000269|PubMed:15116257}.; FUNCTION: [Isoform 4]: Stabilizes BACE1 protein levels and promotes the sorting and accumulation of BACE1 to the recycling or endosomal compartments, modulating the beta-amyloidogenic processing of APP. {ECO:0000269|PubMed:27084579}. |
Q92797 | SYMPK | S1222 | ochoa | Symplekin | Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity. {ECO:0000269|PubMed:16230528, ECO:0000269|PubMed:20861839}. |
Q969W9 | PMEPA1 | S233 | ochoa | Protein TMEPAI (Prostate transmembrane protein androgen induced 1) (Solid tumor-associated 1 protein) (Transmembrane prostate androgen-induced protein) | Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal (PubMed:20129061, PubMed:24627487). Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4 (PubMed:18703514). {ECO:0000269|PubMed:18703514, ECO:0000269|PubMed:20129061, ECO:0000269|PubMed:24627487}. |
Q96DT7 | ZBTB10 | S80 | ochoa | Zinc finger and BTB domain-containing protein 10 (Zinc finger protein RIN ZF) | May be involved in transcriptional regulation. |
Q96G28 | CFAP36 | S201 | ochoa | Cilia- and flagella-associated protein 36 (Coiled-coil domain-containing protein 104) | May act as an effector for ARL3. |
Q96GX5 | MASTL | S631 | ochoa | Serine/threonine-protein kinase greatwall (GW) (GWL) (hGWL) (EC 2.7.11.1) (Microtubule-associated serine/threonine-protein kinase-like) (MAST-L) | Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance (PubMed:19680222). Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively (PubMed:38123684). ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high (PubMed:20818157). Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation. {ECO:0000269|PubMed:12890928, ECO:0000269|PubMed:19680222, ECO:0000269|PubMed:19793917, ECO:0000269|PubMed:20538976, ECO:0000269|PubMed:20818157, ECO:0000269|PubMed:38123684}. |
Q96T37 | RBM15 | S175 | ochoa | RNA-binding protein 15 (One-twenty two protein 1) (RNA-binding motif protein 15) | RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (By similarity). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation (By similarity). Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation (PubMed:26575292). Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen (By similarity). Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL (By similarity). May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing (PubMed:17001072, PubMed:19786495). High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing (PubMed:17001072, PubMed:19786495). May be implicated in HOX gene regulation (PubMed:11344311). {ECO:0000250|UniProtKB:Q0VBL3, ECO:0000269|PubMed:17001072, ECO:0000269|PubMed:19786495, ECO:0000269|PubMed:26575292, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:11344311}. |
Q96TC7 | RMDN3 | S225 | ochoa | Regulator of microtubule dynamics protein 3 (RMD-3) (hRMD-3) (Cerebral protein 10) (Protein FAM82A2) (Protein FAM82C) (Protein tyrosine phosphatase-interacting protein 51) (TCPTP-interacting protein 51) | Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis. {ECO:0000269|PubMed:16820967, ECO:0000269|PubMed:22131369}. |
Q99442 | SEC62 | S356 | ochoa | Translocation protein SEC62 (Translocation protein 1) (TP-1) (hTP-1) | Mediates post-translational transport of precursor polypeptides across endoplasmic reticulum (ER). Proposed to act as a targeting receptor for small presecretory proteins containing short and apolar signal peptides. Targets and properly positions newly synthesized presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen. {ECO:0000269|PubMed:22375059, ECO:0000269|PubMed:29719251}. |
Q9BVA1 | TUBB2B | S115 | ochoa | Tubulin beta-2B chain | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:23001566, PubMed:26732629, PubMed:28013290). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910). {ECO:0000269|PubMed:19465910, ECO:0000269|PubMed:23001566, ECO:0000269|PubMed:26732629, ECO:0000269|PubMed:28013290}. |
Q9BVS4 | RIOK2 | S350 | ochoa|psp | Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (RIO kinase 2) | Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA (PubMed:19564402). Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function (PubMed:21880710). {ECO:0000269|PubMed:16037817, ECO:0000269|PubMed:19564402, ECO:0000269|PubMed:21880710}. |
Q9BW71 | HIRIP3 | S300 | ochoa | HIRA-interacting protein 3 | Histone chaperone that carries a H2A-H2B histone complex and facilitates its deposition onto chromatin. {ECO:0000269|PubMed:38334665, ECO:0000269|PubMed:9710638}. |
Q9BXS6 | NUSAP1 | S149 | ochoa | Nucleolar and spindle-associated protein 1 (NuSAP) | Microtubule-associated protein with the capacity to bundle and stabilize microtubules (By similarity). May associate with chromosomes and promote the organization of mitotic spindle microtubules around them. {ECO:0000250, ECO:0000269|PubMed:12963707}. |
Q9C0B0 | UNK | S411 | ochoa | RING finger protein unkempt homolog (Zinc finger CCCH domain-containing protein 5) | Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280). {ECO:0000269|PubMed:25737280}. |
Q9C0C2 | TNKS1BP1 | S936 | ochoa | 182 kDa tankyrase-1-binding protein | None |
Q9H0W5 | CCDC8 | S401 | ochoa | Coiled-coil domain-containing protein 8 | Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695, PubMed:24793696). Required for localization of CUL7 to the centrosome (PubMed:24793695). {ECO:0000269|PubMed:24793695, ECO:0000269|PubMed:24793696}. |
Q9H0W8 | SMG9 | S53 | ochoa | Nonsense-mediated mRNA decay factor SMG9 | Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:19417104). Is recruited by release factors to stalled ribosomes together with SMG1 and SMG8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between SMG1 and SMG8 (PubMed:19417104). Plays a role in brain, heart, and eye development (By similarity). {ECO:0000250|UniProtKB:Q9DB90, ECO:0000269|PubMed:19417104}. |
Q9H773 | DCTPP1 | S150 | ochoa | dCTP pyrophosphatase 1 (EC 3.6.1.12) (Deoxycytidine-triphosphatase 1) (dCTPase 1) (RS21C6) (XTP3-transactivated gene A protein) | Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism. {ECO:0000269|PubMed:24467396}. |
Q9NSI6 | BRWD1 | S2011 | ochoa | Bromodomain and WD repeat-containing protein 1 (WD repeat-containing protein 9) | May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000250, ECO:0000269|PubMed:21834987}. |
Q9NUQ6 | SPATS2L | S526 | ochoa | SPATS2-like protein (DNA polymerase-transactivated protein 6) (Stress granule and nucleolar protein) (SGNP) | None |
Q9NX61 | TMEM161A | S69 | ochoa | Transmembrane protein 161A (Adaptive response to oxidative stress protein 29) (AROS-29) | May play a role in protection against oxidative stress. Overexpression leads to reduced levels of oxidant-induced DNA damage and apoptosis. {ECO:0000269|PubMed:16551573}. |
Q9UGI8 | TES | S140 | ochoa | Testin (TESS) | Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. Inhibits tumor cell growth. {ECO:0000269|PubMed:11420696, ECO:0000269|PubMed:12571287, ECO:0000269|PubMed:12695497}. |
Q9UID3 | VPS51 | S44 | ochoa | Vacuolar protein sorting-associated protein 51 homolog (Another new gene 2 protein) (Protein fat-free homolog) | Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN (PubMed:20685960). Acts as a component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane (PubMed:25799061). {ECO:0000269|PubMed:20685960, ECO:0000269|PubMed:25799061}. |
Q9UJM3 | ERRFI1 | S391 | ochoa | ERBB receptor feedback inhibitor 1 (Mitogen-inducible gene 6 protein) (MIG-6) | Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity). {ECO:0000250}. |
Q9UKN1 | MUC12 | S5442 | ochoa | Mucin-12 (MUC-12) (Mucin-11) (MUC-11) | Involved in epithelial cell protection, adhesion modulation, and signaling. May be involved in epithelial cell growth regulation. Stimulated by both cytokine TNF-alpha and TGF-beta in intestinal epithelium. {ECO:0000269|PubMed:17058067}. |
Q9ULU4 | ZMYND8 | S533 | ochoa | MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8) | Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) (PubMed:26655721, PubMed:27477906, PubMed:31965980, PubMed:36064715). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac (PubMed:27477906). May also act as a transcriptional corepressor for KDM5C and EZH2 (PubMed:33323928). Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309, PubMed:27732854, PubMed:30134174). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (PubMed:26655721, PubMed:30134174). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression (PubMed:26655721). Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform (PubMed:30134174, PubMed:35916866, PubMed:36064715). Suppresses breast cancer, and prostate cancer cell invasion and metastasis (PubMed:27477906, PubMed:31965980, PubMed:33323928). {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:26655721, ECO:0000269|PubMed:27477906, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:31965980, ECO:0000269|PubMed:33323928, ECO:0000269|PubMed:35916866, ECO:0000269|PubMed:36064715}. |
Q9ULU4 | ZMYND8 | S1119 | ochoa | MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8) | Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) (PubMed:26655721, PubMed:27477906, PubMed:31965980, PubMed:36064715). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac (PubMed:27477906). May also act as a transcriptional corepressor for KDM5C and EZH2 (PubMed:33323928). Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309, PubMed:27732854, PubMed:30134174). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (PubMed:26655721, PubMed:30134174). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression (PubMed:26655721). Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform (PubMed:30134174, PubMed:35916866, PubMed:36064715). Suppresses breast cancer, and prostate cancer cell invasion and metastasis (PubMed:27477906, PubMed:31965980, PubMed:33323928). {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:26655721, ECO:0000269|PubMed:27477906, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:31965980, ECO:0000269|PubMed:33323928, ECO:0000269|PubMed:35916866, ECO:0000269|PubMed:36064715}. |
Q9UMS6 | SYNPO2 | S274 | ochoa | Synaptopodin-2 (Genethonin-2) (Myopodin) | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. |
Q9UNF1 | MAGED2 | S84 | ochoa | Melanoma-associated antigen D2 (11B6) (Breast cancer-associated gene 1 protein) (BCG-1) (Hepatocellular carcinoma-associated protein JCL-1) (MAGE-D2 antigen) | Regulates the expression, localization to the plasma membrane and function of the sodium chloride cotransporters SLC12A1 and SLC12A3, two key components of salt reabsorption in the distal renal tubule. {ECO:0000269|PubMed:27120771}. |
Q9Y285 | FARSA | S198 | ochoa | Phenylalanine--tRNA ligase alpha subunit (EC 6.1.1.20) (CML33) (Phenylalanyl-tRNA synthetase alpha subunit) (PheRS) | None |
Q9Y2J4 | AMOTL2 | S549 | ochoa | Angiomotin-like protein 2 (Leman coiled-coil protein) (LCCP) | Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Plays a role in coupling actin fibers to cell junctions in endothelial cells and is therefore required for correct endothelial cell morphology via facilitating transcellular transmission of mechanical force resulting in endothelial cell elongation (By similarity). Required for the anchoring of radial actin fibers to CDH1 junction complexes at the cell membrane which facilitates organization of radial actin fiber structure and cellular response to contractile forces (PubMed:28842668). This contributes to maintenance of cell area, size, shape, epithelial sheet organization and trophectoderm cell properties that facilitate blastocyst zona hatching (PubMed:28842668). Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. Activates the Hippo signaling pathway in response to cell contact inhibition via interaction with and ubiquitination by Crumbs complex-bound WWP1 (PubMed:34404733). Ubiquitinated AMOTL2 then interacts with LATS2 which in turn phosphorylates YAP1, excluding it from the nucleus and localizing it to the cytoplasm and tight junctions, therefore ultimately repressing YAP1-driven transcription of target genes (PubMed:17293535, PubMed:21205866, PubMed:26598551). Acts to inhibit WWTR1/TAZ transcriptional coactivator activity via sequestering WWTR1/TAZ in the cytoplasm and at tight junctions (PubMed:23911299). Regulates the size and protein composition of the podosome cortex and core at myofibril neuromuscular junctions (PubMed:23525008). Selectively promotes FGF-induced MAPK activation through SRC (PubMed:17293535). May play a role in the polarity, proliferation and migration of endothelial cells. {ECO:0000250|UniProtKB:Q8K371, ECO:0000269|PubMed:17293535, ECO:0000269|PubMed:21205866, ECO:0000269|PubMed:21937427, ECO:0000269|PubMed:22362771, ECO:0000269|PubMed:23525008, ECO:0000269|PubMed:23911299, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:28842668, ECO:0000269|PubMed:34404733}. |
Q9Y6R9 | CCDC61 | S469 | ochoa | Centrosomal protein CCDC61 (Coiled-coil domain-containing protein 61) (VFL3 homolog) | Microtubule-binding centrosomal protein required for centriole cohesion, independently of the centrosome-associated protein/CEP250 and rootletin/CROCC linker (PubMed:31789463). In interphase, required for anchoring microtubule at the mother centriole subdistal appendages and for centrosome positioning (PubMed:31789463). During mitosis, may be involved in spindle assembly and chromatin alignment by regulating the organization of spindle microtubules into a symmetrical structure (PubMed:30354798). Has been proposed to play a role in CEP170 recruitment to centrosomes (PubMed:30354798). However, this function could not be confirmed (PubMed:31789463). Plays a non-essential role in ciliogenesis (PubMed:31789463, PubMed:32375023). {ECO:0000269|PubMed:30354798, ECO:0000269|PubMed:31789463, ECO:0000269|PubMed:32375023}. |
P00558 | PGK1 | S393 | Sugiyama | Phosphoglycerate kinase 1 (EC 2.7.11.1) (EC 2.7.2.3) (Cell migration-inducing gene 10 protein) (Primer recognition protein 2) (PRP 2) | Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate (PubMed:30323285, PubMed:7391028). Both L- and D- forms of purine and pyrimidine nucleotides can be used as substrates, but the activity is much lower on pyrimidines (PubMed:18463139). In addition to its role as a glycolytic enzyme, it seems that PGK1 acts as a polymerase alpha cofactor protein (primer recognition protein) (PubMed:2324090). Acts as a protein kinase when localized to the mitochondrion where it phosphorylates pyruvate dehydrogenase kinase PDK1 to inhibit pyruvate dehydrogenase complex activity and suppress the formation of acetyl-coenzyme A from pyruvate, and consequently inhibit oxidative phosphorylation and promote glycolysis (PubMed:26942675, PubMed:36849569). May play a role in sperm motility (PubMed:26677959). {ECO:0000269|PubMed:18463139, ECO:0000269|PubMed:2324090, ECO:0000269|PubMed:26677959, ECO:0000269|PubMed:26942675, ECO:0000269|PubMed:30323285, ECO:0000269|PubMed:36849569, ECO:0000269|PubMed:7391028}. |
P07205 | PGK2 | S393 | Sugiyama | Phosphoglycerate kinase 2 (EC 2.7.2.3) (Phosphoglycerate kinase, testis specific) | Essential for sperm motility and male fertility (PubMed:26677959). Not required for the completion of spermatogenesis (By similarity). {ECO:0000250|UniProtKB:P09041, ECO:0000269|PubMed:26677959}. |
P27797 | CALR | S52 | Sugiyama | Calreticulin (CRP55) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP) (grp60) | Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (PubMed:7876246). Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (PubMed:11149926). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity). {ECO:0000250|UniProtKB:P28491, ECO:0000250|UniProtKB:Q8K3H7, ECO:0000269|PubMed:11149926, ECO:0000269|PubMed:7876246}. |
Q9HDC9 | APMAP | S188 | Sugiyama | Adipocyte plasma membrane-associated protein (Protein BSCv) | Exhibits strong arylesterase activity with beta-naphthyl acetate and phenyl acetate. May play a role in adipocyte differentiation. {ECO:0000269|PubMed:18513186}. |
Q14694 | USP10 | S265 | Sugiyama | Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.4.19.12) (Deubiquitinating enzyme 10) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10) | Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, RPS2/us5, RPS3/us3, RPS10/eS10, BECN1, SNX3 and CFTR (PubMed:11439350, PubMed:18632802, PubMed:31981475). Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53 (PubMed:20096447). Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response (PubMed:20096447). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes (PubMed:21962518). In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13 (PubMed:21962518). Does not deubiquitinate MDM2 (PubMed:20096447). Plays a key role in 40S ribosome subunit recycling when a ribosome has stalled during translation: acts both by inhibiting formation of stress granules, which store stalled translation pre-initiation complexes, and mediating deubiquitination of 40S ribosome subunits (PubMed:27022092, PubMed:31981475, PubMed:34348161, PubMed:34469731). Acts as a negative regulator of stress granules formation by lowering G3BP1 and G3BP2 valence, thereby preventing G3BP1 and G3BP2 ability to undergo liquid-liquid phase separation (LLPS) and assembly of stress granules (PubMed:11439350, PubMed:27022092, PubMed:32302570). Promotes 40S ribosome subunit recycling following ribosome dissociation in response to ribosome stalling by mediating deubiquitination of 40S ribosomal proteins RPS2/us5, RPS3/us3 and RPS10/eS10, thereby preventing their degradation by the proteasome (PubMed:31981475, PubMed:34348161, PubMed:34469731). Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC): USP10 acts by removing monoubiquitination of RPS2/us5 and RPS3/us3, promoting 40S ribosomal subunit recycling (PubMed:34469731). Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling (PubMed:19398555). Involved in a TANK-dependent negative feedback response to attenuate NF-kappa-B activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Deubiquitinates TBX21 leading to its stabilization (PubMed:24845384). Plays a negative role in the RLR signaling pathway upon RNA virus infection by blocking the RIGI-mediated MAVS activation. Mechanistically, removes the unanchored 'Lys-63'-linked polyubiquitin chains of MAVS to inhibit its aggregation, essential for its activation (PubMed:37582970). {ECO:0000269|PubMed:11439350, ECO:0000269|PubMed:18632802, ECO:0000269|PubMed:19398555, ECO:0000269|PubMed:20096447, ECO:0000269|PubMed:21962518, ECO:0000269|PubMed:24845384, ECO:0000269|PubMed:25861989, ECO:0000269|PubMed:27022092, ECO:0000269|PubMed:31981475, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:34348161, ECO:0000269|PubMed:34469731, ECO:0000269|PubMed:37582970}. |
Q13765 | NACA | S132 | Sugiyama | Nascent polypeptide-associated complex subunit alpha (NAC-alpha) (Alpha-NAC) (allergen Hom s 2) | Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters. {ECO:0000269|PubMed:10982809, ECO:0000269|PubMed:15784678, ECO:0000269|PubMed:9877153}. |
P60174 | TPI1 | S97 | Sugiyama | Triosephosphate isomerase (TIM) (EC 5.3.1.1) (Methylglyoxal synthase) (EC 4.2.3.3) (Triose-phosphate isomerase) | Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. {ECO:0000269|PubMed:18562316}.; FUNCTION: It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids. {ECO:0000250|UniProtKB:P00939}. |
P09960 | LTA4H | S236 | Sugiyama | Leukotriene A-4 hydrolase (LTA-4 hydrolase) (EC 3.3.2.6) (Leukotriene A(4) hydrolase) (Tripeptide aminopeptidase LTA4H) (EC 3.4.11.4) | Bifunctional zinc metalloenzyme that comprises both epoxide hydrolase (EH) and aminopeptidase activities. Acts as an epoxide hydrolase to catalyze the conversion of LTA4 to the pro-inflammatory mediator leukotriene B4 (LTB4) (PubMed:11917124, PubMed:12207002, PubMed:15078870, PubMed:18804029, PubMed:1897988, PubMed:1975494, PubMed:2244921). Also has aminopeptidase activity, with high affinity for N-terminal arginines of various synthetic tripeptides (PubMed:18804029, PubMed:20813919). In addition to its pro-inflammatory EH activity, may also counteract inflammation by its aminopeptidase activity, which inactivates by cleavage another neutrophil attractant, the tripeptide Pro-Gly-Pro (PGP), a bioactive fragment of collagen generated by the action of matrix metalloproteinase-9 (MMP9) and prolylendopeptidase (PREPL) (PubMed:20813919, PubMed:24591641). Involved also in the biosynthesis of resolvin E1 and 18S-resolvin E1 from eicosapentaenoic acid, two lipid mediators that show potent anti-inflammatory and pro-resolving actions (PubMed:21206090). {ECO:0000269|PubMed:11917124, ECO:0000269|PubMed:12207002, ECO:0000269|PubMed:15078870, ECO:0000269|PubMed:18804029, ECO:0000269|PubMed:1897988, ECO:0000269|PubMed:1975494, ECO:0000269|PubMed:20813919, ECO:0000269|PubMed:21206090, ECO:0000269|PubMed:2244921, ECO:0000269|PubMed:24591641}. |
P00505 | GOT2 | S118 | Sugiyama | Aspartate aminotransferase, mitochondrial (mAspAT) (EC 2.6.1.1) (EC 2.6.1.7) (Fatty acid-binding protein) (FABP-1) (Glutamate oxaloacetate transaminase 2) (Kynurenine aminotransferase 4) (Kynurenine aminotransferase IV) (Kynurenine--oxoglutarate transaminase 4) (Kynurenine--oxoglutarate transaminase IV) (Plasma membrane-associated fatty acid-binding protein) (FABPpm) (Transaminase A) | Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism. Facilitates cellular uptake of long-chain free fatty acids. {ECO:0000269|PubMed:31422819, ECO:0000269|PubMed:9537447}. |
P22102 | GART | S106 | Sugiyama | Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (Glycinamide ribonucleotide synthetase) (GARS) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIR synthase) (AIRS) (Phosphoribosyl-aminoimidazole synthetase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (5'-phosphoribosylglycinamide transformylase) (GAR transformylase) (GART)] | Trifunctional enzyme that catalyzes three distinct reactions as part of the 'de novo' inosine monophosphate biosynthetic pathway. {ECO:0000305|PubMed:12450384, ECO:0000305|PubMed:12755606, ECO:0000305|PubMed:20631005, ECO:0000305|PubMed:2183217}. |
P10636 | MAPT | S355 | SIGNOR | Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}. |
Q8N5S9 | CAMKK1 | S69 | Sugiyama | Calcium/calmodulin-dependent protein kinase kinase 1 (CaM-KK 1) (CaM-kinase kinase 1) (CaMKK 1) (EC 2.7.11.17) (CaM-kinase IV kinase) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-KK alpha) (CaM-kinase kinase alpha) (CaMKK alpha) | Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. {ECO:0000269|PubMed:12935886}. |
Q8TD08 | MAPK15 | S442 | Sugiyama | Mitogen-activated protein kinase 15 (MAP kinase 15) (MAPK 15) (EC 2.7.11.24) (Extracellular signal-regulated kinase 7) (ERK-7) (Extracellular signal-regulated kinase 8) (ERK-8) | Atypical MAPK protein that regulates several process such as autophagy, ciliogenesis, protein trafficking/secretion and genome integrity, in a kinase activity-dependent manner (PubMed:20733054, PubMed:21847093, PubMed:22948227, PubMed:24618899, PubMed:29021280). Controls both, basal and starvation-induced autophagy throught its interaction with GABARAP, MAP1LC3B and GABARAPL1 leading to autophagosome formation, SQSTM1 degradation and reduced MAP1LC3B inhibitory phosphorylation (PubMed:22948227). Regulates primary cilium formation and the localization of ciliary proteins involved in cilium structure, transport, and signaling (PubMed:29021280). Prevents the relocation of the sugar-adding enzymes from the Golgi to the endoplasmic reticulum, thereby restricting the production of sugar-coated proteins (PubMed:24618899). Upon amino-acid starvation, mediates transitional endoplasmic reticulum site disassembly and inhibition of secretion (PubMed:21847093). Binds to chromatin leading to MAPK15 activation and interaction with PCNA, that which protects genomic integrity by inhibiting MDM2-mediated degradation of PCNA (PubMed:20733054). Regulates DA transporter (DAT) activity and protein expression via activation of RhoA (PubMed:28842414). In response to H(2)O(2) treatment phosphorylates ELAVL1, thus preventing it from binding to the PDCD4 3'UTR and rendering the PDCD4 mRNA accessible to miR-21 and leading to its degradation and loss of protein expression (PubMed:26595526). Also functions in a kinase activity-independent manner as a negative regulator of growth (By similarity). Phosphorylates in vitro FOS and MBP (PubMed:11875070, PubMed:16484222, PubMed:19166846, PubMed:20638370). During oocyte maturation, plays a key role in the microtubule organization and meiotic cell cycle progression in oocytes, fertilized eggs, and early embryos (By similarity). Interacts with ESRRA promoting its re-localization from the nucleus to the cytoplasm and then prevents its transcriptional activity (PubMed:21190936). {ECO:0000250|UniProtKB:Q80Y86, ECO:0000250|UniProtKB:Q9Z2A6, ECO:0000269|PubMed:11875070, ECO:0000269|PubMed:16484222, ECO:0000269|PubMed:19166846, ECO:0000269|PubMed:20638370, ECO:0000269|PubMed:20733054, ECO:0000269|PubMed:21190936, ECO:0000269|PubMed:21847093, ECO:0000269|PubMed:22948227, ECO:0000269|PubMed:24618899, ECO:0000269|PubMed:26595526, ECO:0000269|PubMed:28842414, ECO:0000269|PubMed:29021280}. |
Q9H093 | NUAK2 | S492 | Sugiyama | NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (Omphalocele kinase 2) (SNF1/AMP kinase-related kinase) (SNARK) | Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Phosphorylates LATS1 and LATS2. Plays a key role in neural tube closure during embryonic development through LATS2 phosphorylation and regulation of the nuclear localization of YAP1 a critical downstream regulatory target in the Hippo signaling pathway (PubMed:32845958). {ECO:0000269|PubMed:14575707, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15345718, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:32845958}. |
Q01081 | U2AF1 | S19 | Sugiyama | Splicing factor U2AF 35 kDa subunit (U2 auxiliary factor 35 kDa subunit) (U2 small nuclear RNA auxiliary factor 1) (U2 snRNP auxiliary factor small subunit) | Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron. {ECO:0000269|PubMed:22158538, ECO:0000269|PubMed:25311244, ECO:0000269|PubMed:8647433}. |
Q8WU68 | U2AF1L4 | S19 | Sugiyama | Splicing factor U2AF 26 kDa subunit (U2 auxiliary factor 26) (U2 small nuclear RNA auxiliary factor 1-like protein 4) (U2AF1-like 4) (U2(RNU2) small nuclear RNA auxiliary factor 1-like protein 3) (U2 small nuclear RNA auxiliary factor 1-like protein 3) (U2AF1-like protein 3) | RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3'-splice site (By similarity). Shows a preference for AGC or AGA (By similarity). {ECO:0000250|UniProtKB:Q8BGJ9}. |
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reactome_id | name | p | -log10_p |
---|---|---|---|
R-HSA-437239 | Recycling pathway of L1 | 2.341236e-08 | 7.631 |
R-HSA-190828 | Gap junction trafficking | 3.032758e-07 | 6.518 |
R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 4.619627e-07 | 6.335 |
R-HSA-157858 | Gap junction trafficking and regulation | 5.574872e-07 | 6.254 |
R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 1.017665e-06 | 5.992 |
R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 1.274343e-06 | 5.895 |
R-HSA-190872 | Transport of connexons to the plasma membrane | 1.581126e-06 | 5.801 |
R-HSA-373760 | L1CAM interactions | 1.513437e-06 | 5.820 |
R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 1.845728e-06 | 5.734 |
R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 4.844547e-06 | 5.315 |
R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 5.546181e-06 | 5.256 |
R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 9.450012e-06 | 5.025 |
R-HSA-9833482 | PKR-mediated signaling | 9.450012e-06 | 5.025 |
R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 1.554327e-05 | 4.808 |
R-HSA-9663891 | Selective autophagy | 1.758145e-05 | 4.755 |
R-HSA-438064 | Post NMDA receptor activation events | 1.646205e-05 | 4.784 |
R-HSA-190861 | Gap junction assembly | 2.529872e-05 | 4.597 |
R-HSA-9646399 | Aggrephagy | 4.815585e-05 | 4.317 |
R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 4.595227e-05 | 4.338 |
R-HSA-1632852 | Macroautophagy | 5.380319e-05 | 4.269 |
R-HSA-389977 | Post-chaperonin tubulin folding pathway | 5.990242e-05 | 4.223 |
R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 5.854238e-05 | 4.233 |
R-HSA-8949215 | Mitochondrial calcium ion transport | 8.047248e-05 | 4.094 |
R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 1.003008e-04 | 3.999 |
R-HSA-9612973 | Autophagy | 1.043993e-04 | 3.981 |
R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 1.203494e-04 | 3.920 |
R-HSA-9022534 | Loss of MECP2 binding ability to 5hmC-DNA | 1.319440e-04 | 3.880 |
R-HSA-913531 | Interferon Signaling | 1.339915e-04 | 3.873 |
R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 1.636738e-04 | 3.786 |
R-HSA-8986944 | Transcriptional Regulation by MECP2 | 1.926165e-04 | 3.715 |
R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 1.877382e-04 | 3.726 |
R-HSA-6807878 | COPI-mediated anterograde transport | 2.759377e-04 | 3.559 |
R-HSA-983189 | Kinesins | 2.662306e-04 | 3.575 |
R-HSA-422475 | Axon guidance | 2.447726e-04 | 3.611 |
R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 3.037750e-04 | 3.517 |
R-HSA-9022692 | Regulation of MECP2 expression and activity | 3.247516e-04 | 3.488 |
R-HSA-70171 | Glycolysis | 3.349029e-04 | 3.475 |
R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 4.407437e-04 | 3.356 |
R-HSA-9675108 | Nervous system development | 4.600013e-04 | 3.337 |
R-HSA-1852241 | Organelle biogenesis and maintenance | 5.302911e-04 | 3.275 |
R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 5.245511e-04 | 3.280 |
R-HSA-446353 | Cell-extracellular matrix interactions | 5.492470e-04 | 3.260 |
R-HSA-9022538 | Loss of MECP2 binding ability to 5mC-DNA | 8.114711e-04 | 3.091 |
R-HSA-70326 | Glucose metabolism | 7.925934e-04 | 3.101 |
R-HSA-2132295 | MHC class II antigen presentation | 9.965624e-04 | 3.001 |
R-HSA-9022927 | MECP2 regulates transcription of genes involved in GABA signaling | 1.162268e-03 | 2.935 |
R-HSA-5620924 | Intraflagellar transport | 1.240494e-03 | 2.906 |
R-HSA-70263 | Gluconeogenesis | 1.240494e-03 | 2.906 |
R-HSA-390466 | Chaperonin-mediated protein folding | 1.244840e-03 | 2.905 |
R-HSA-9022535 | Loss of phosphorylation of MECP2 at T308 | 1.573519e-03 | 2.803 |
R-HSA-69275 | G2/M Transition | 1.601414e-03 | 2.795 |
R-HSA-391251 | Protein folding | 1.621386e-03 | 2.790 |
R-HSA-453274 | Mitotic G2-G2/M phases | 1.691237e-03 | 2.772 |
R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 2.044229e-03 | 2.689 |
R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 1.994149e-03 | 2.700 |
R-HSA-1266695 | Interleukin-7 signaling | 2.221064e-03 | 2.653 |
R-HSA-445095 | Interaction between L1 and Ankyrins | 2.647643e-03 | 2.577 |
R-HSA-199977 | ER to Golgi Anterograde Transport | 2.528068e-03 | 2.597 |
R-HSA-1640170 | Cell Cycle | 2.744257e-03 | 2.562 |
R-HSA-9022707 | MECP2 regulates transcription factors | 3.160104e-03 | 2.500 |
R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 3.178597e-03 | 2.498 |
R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 3.368981e-03 | 2.473 |
R-HSA-68882 | Mitotic Anaphase | 3.488227e-03 | 2.457 |
R-HSA-2555396 | Mitotic Metaphase and Anaphase | 3.569112e-03 | 2.447 |
R-HSA-196025 | Formation of annular gap junctions | 3.803337e-03 | 2.420 |
R-HSA-176187 | Activation of ATR in response to replication stress | 4.217544e-03 | 2.375 |
R-HSA-190873 | Gap junction degradation | 4.502166e-03 | 2.347 |
R-HSA-9022702 | MECP2 regulates transcription of neuronal ligands | 5.255654e-03 | 2.279 |
R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 5.321946e-03 | 2.274 |
R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 5.518624e-03 | 2.258 |
R-HSA-68886 | M Phase | 6.210945e-03 | 2.207 |
R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 6.438456e-03 | 2.191 |
R-HSA-201556 | Signaling by ALK | 6.639828e-03 | 2.178 |
R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 6.690948e-03 | 2.175 |
R-HSA-4839748 | Signaling by AMER1 mutants | 6.922919e-03 | 2.160 |
R-HSA-5617833 | Cilium Assembly | 7.819206e-03 | 2.107 |
R-HSA-9609646 | HCMV Infection | 7.134484e-03 | 2.147 |
R-HSA-8856688 | Golgi-to-ER retrograde transport | 7.752236e-03 | 2.111 |
R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 6.922919e-03 | 2.160 |
R-HSA-9005895 | Pervasive developmental disorders | 7.834878e-03 | 2.106 |
R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 7.834878e-03 | 2.106 |
R-HSA-9697154 | Disorders of Nervous System Development | 7.834878e-03 | 2.106 |
R-HSA-5688426 | Deubiquitination | 7.846984e-03 | 2.105 |
R-HSA-5467343 | Deletions in the AMER1 gene destabilize the destruction complex | 8.163977e-03 | 2.088 |
R-HSA-68877 | Mitotic Prometaphase | 8.351484e-03 | 2.078 |
R-HSA-1280215 | Cytokine Signaling in Immune system | 8.382106e-03 | 2.077 |
R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 8.797862e-03 | 2.056 |
R-HSA-9609690 | HCMV Early Events | 8.909356e-03 | 2.050 |
R-HSA-69278 | Cell Cycle, Mitotic | 9.207845e-03 | 2.036 |
R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 1.087339e-02 | 1.964 |
R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 9.694126e-03 | 2.013 |
R-HSA-948021 | Transport to the Golgi and subsequent modification | 1.010449e-02 | 1.995 |
R-HSA-9675151 | Disorders of Developmental Biology | 1.314259e-02 | 1.881 |
R-HSA-72187 | mRNA 3'-end processing | 1.356808e-02 | 1.867 |
R-HSA-5610787 | Hedgehog 'off' state | 1.358896e-02 | 1.867 |
R-HSA-9913635 | Strand-asynchronous mitochondrial DNA replication | 1.689480e-02 | 1.772 |
R-HSA-2467813 | Separation of Sister Chromatids | 1.753891e-02 | 1.756 |
R-HSA-73856 | RNA Polymerase II Transcription Termination | 1.957450e-02 | 1.708 |
R-HSA-5689880 | Ub-specific processing proteases | 2.150236e-02 | 1.668 |
R-HSA-5628897 | TP53 Regulates Metabolic Genes | 2.163369e-02 | 1.665 |
R-HSA-1592230 | Mitochondrial biogenesis | 2.329971e-02 | 1.633 |
R-HSA-112315 | Transmission across Chemical Synapses | 2.348621e-02 | 1.629 |
R-HSA-5674404 | PTEN Loss of Function in Cancer | 2.429401e-02 | 1.615 |
R-HSA-8943723 | Regulation of PTEN mRNA translation | 2.402355e-02 | 1.619 |
R-HSA-9636667 | Manipulation of host energy metabolism | 2.429401e-02 | 1.615 |
R-HSA-163282 | Mitochondrial transcription initiation | 2.429401e-02 | 1.615 |
R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 2.847343e-02 | 1.546 |
R-HSA-8953854 | Metabolism of RNA | 2.392177e-02 | 1.621 |
R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 2.860959e-02 | 1.543 |
R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 2.879160e-02 | 1.541 |
R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 2.952341e-02 | 1.530 |
R-HSA-69481 | G2/M Checkpoints | 3.006426e-02 | 1.522 |
R-HSA-187037 | Signaling by NTRK1 (TRKA) | 3.073095e-02 | 1.512 |
R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 3.216234e-02 | 1.493 |
R-HSA-75944 | Transcription from mitochondrial promoters | 3.226113e-02 | 1.491 |
R-HSA-109582 | Hemostasis | 3.334663e-02 | 1.477 |
R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 3.390316e-02 | 1.470 |
R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 3.749218e-02 | 1.426 |
R-HSA-9034793 | Activated NTRK3 signals through PLCG1 | 4.016369e-02 | 1.396 |
R-HSA-167021 | PLC-gamma1 signalling | 4.016369e-02 | 1.396 |
R-HSA-9026527 | Activated NTRK2 signals through PLCG1 | 4.800219e-02 | 1.319 |
R-HSA-1251932 | PLCG1 events in ERBB2 signaling | 4.800219e-02 | 1.319 |
R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 4.121980e-02 | 1.385 |
R-HSA-4791275 | Signaling by WNT in cancer | 3.933901e-02 | 1.405 |
R-HSA-5205647 | Mitophagy | 4.508062e-02 | 1.346 |
R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 4.508062e-02 | 1.346 |
R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 4.121980e-02 | 1.385 |
R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 4.705934e-02 | 1.327 |
R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 4.508062e-02 | 1.346 |
R-HSA-5358351 | Signaling by Hedgehog | 3.941269e-02 | 1.404 |
R-HSA-166520 | Signaling by NTRKs | 4.848177e-02 | 1.314 |
R-HSA-8853659 | RET signaling | 4.906940e-02 | 1.309 |
R-HSA-199991 | Membrane Trafficking | 4.915077e-02 | 1.308 |
R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 5.111018e-02 | 1.291 |
R-HSA-5689896 | Ovarian tumor domain proteases | 5.111018e-02 | 1.291 |
R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 5.318103e-02 | 1.274 |
R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 5.528135e-02 | 1.257 |
R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 5.741053e-02 | 1.241 |
R-HSA-5674135 | MAP2K and MAPK activation | 6.175303e-02 | 1.209 |
R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 5.956795e-02 | 1.225 |
R-HSA-9656223 | Signaling by RAF1 mutants | 6.175303e-02 | 1.209 |
R-HSA-9649948 | Signaling downstream of RAS mutants | 7.307297e-02 | 1.136 |
R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 7.307297e-02 | 1.136 |
R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 7.307297e-02 | 1.136 |
R-HSA-199920 | CREB phosphorylation | 7.113856e-02 | 1.148 |
R-HSA-69478 | G2/M DNA replication checkpoint | 7.113856e-02 | 1.148 |
R-HSA-6802949 | Signaling by RAS mutants | 7.307297e-02 | 1.136 |
R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 7.084855e-02 | 1.150 |
R-HSA-72312 | rRNA processing | 5.730795e-02 | 1.242 |
R-HSA-8849468 | PTK6 Regulates Proteins Involved in RNA Processing | 5.577717e-02 | 1.254 |
R-HSA-1489509 | DAG and IP3 signaling | 7.075827e-02 | 1.150 |
R-HSA-168256 | Immune System | 6.801449e-02 | 1.167 |
R-HSA-597592 | Post-translational protein modification | 5.695371e-02 | 1.244 |
R-HSA-9637690 | Response of Mtb to phagocytosis | 6.620382e-02 | 1.179 |
R-HSA-168316 | Assembly of Viral Components at the Budding Site | 5.577717e-02 | 1.254 |
R-HSA-75153 | Apoptotic execution phase | 7.307297e-02 | 1.136 |
R-HSA-3928662 | EPHB-mediated forward signaling | 6.846837e-02 | 1.165 |
R-HSA-9675135 | Diseases of DNA repair | 7.307297e-02 | 1.136 |
R-HSA-446203 | Asparagine N-linked glycosylation | 7.310368e-02 | 1.136 |
R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 7.467223e-02 | 1.127 |
R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 7.516163e-02 | 1.124 |
R-HSA-9700206 | Signaling by ALK in cancer | 7.516163e-02 | 1.124 |
R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 7.541191e-02 | 1.123 |
R-HSA-8948747 | Regulation of PTEN localization | 7.872598e-02 | 1.104 |
R-HSA-212718 | EGFR interacts with phospholipase C-gamma | 8.625190e-02 | 1.064 |
R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 1.011212e-01 | 0.995 |
R-HSA-390450 | Folding of actin by CCT/TriC | 1.011212e-01 | 0.995 |
R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 1.084655e-01 | 0.965 |
R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 1.084655e-01 | 0.965 |
R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 1.084655e-01 | 0.965 |
R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 1.084655e-01 | 0.965 |
R-HSA-5339716 | Signaling by GSK3beta mutants | 1.157503e-01 | 0.936 |
R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 1.229760e-01 | 0.910 |
R-HSA-3000484 | Scavenging by Class F Receptors | 1.229760e-01 | 0.910 |
R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 1.229760e-01 | 0.910 |
R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 1.229760e-01 | 0.910 |
R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 1.229760e-01 | 0.910 |
R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 1.229760e-01 | 0.910 |
R-HSA-5654227 | Phospholipase C-mediated cascade; FGFR3 | 1.372520e-01 | 0.862 |
R-HSA-196299 | Beta-catenin phosphorylation cascade | 1.443033e-01 | 0.841 |
R-HSA-5654228 | Phospholipase C-mediated cascade; FGFR4 | 1.443033e-01 | 0.841 |
R-HSA-5083636 | Defective GALNT12 causes CRCS1 | 1.512974e-01 | 0.820 |
R-HSA-5083625 | Defective GALNT3 causes HFTC | 1.512974e-01 | 0.820 |
R-HSA-77595 | Processing of Intronless Pre-mRNAs | 1.582348e-01 | 0.801 |
R-HSA-5654219 | Phospholipase C-mediated cascade: FGFR1 | 1.651159e-01 | 0.782 |
R-HSA-5083632 | Defective C1GALT1C1 causes TNPS | 1.651159e-01 | 0.782 |
R-HSA-5654221 | Phospholipase C-mediated cascade; FGFR2 | 1.854260e-01 | 0.732 |
R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 1.854260e-01 | 0.732 |
R-HSA-912526 | Interleukin receptor SHC signaling | 2.117453e-01 | 0.674 |
R-HSA-977068 | Termination of O-glycan biosynthesis | 2.117453e-01 | 0.674 |
R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 1.157101e-01 | 0.937 |
R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 1.157101e-01 | 0.937 |
R-HSA-8854518 | AURKA Activation by TPX2 | 1.237769e-01 | 0.907 |
R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 1.430933e-01 | 0.844 |
R-HSA-380287 | Centrosome maturation | 1.487249e-01 | 0.828 |
R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 1.981098e-01 | 0.703 |
R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 2.010797e-01 | 0.697 |
R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 2.130090e-01 | 0.672 |
R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 1.951456e-01 | 0.710 |
R-HSA-8943724 | Regulation of PTEN gene transcription | 1.077867e-01 | 0.967 |
R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 8.264018e-02 | 1.083 |
R-HSA-8983432 | Interleukin-15 signaling | 1.229760e-01 | 0.910 |
R-HSA-9020958 | Interleukin-21 signaling | 9.371680e-02 | 1.028 |
R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 1.210727e-01 | 0.917 |
R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 8.264018e-02 | 1.083 |
R-HSA-156902 | Peptide chain elongation | 1.892349e-01 | 0.723 |
R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 1.004789e-01 | 0.998 |
R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 9.371680e-02 | 1.028 |
R-HSA-6807070 | PTEN Regulation | 1.372229e-01 | 0.863 |
R-HSA-6798695 | Neutrophil degranulation | 1.997079e-01 | 0.700 |
R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 2.160025e-01 | 0.666 |
R-HSA-72764 | Eukaryotic Translation Termination | 2.160025e-01 | 0.666 |
R-HSA-9020558 | Interleukin-2 signaling | 1.084655e-01 | 0.965 |
R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 1.347358e-01 | 0.871 |
R-HSA-918233 | TRAF3-dependent IRF activation pathway | 1.582348e-01 | 0.801 |
R-HSA-8985947 | Interleukin-9 signaling | 8.625190e-02 | 1.064 |
R-HSA-6802957 | Oncogenic MAPK signaling | 1.774935e-01 | 0.751 |
R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 9.371680e-02 | 1.028 |
R-HSA-176974 | Unwinding of DNA | 9.371680e-02 | 1.028 |
R-HSA-4839744 | Signaling by APC mutants | 1.084655e-01 | 0.965 |
R-HSA-4839735 | Signaling by AXIN mutants | 1.157503e-01 | 0.936 |
R-HSA-418890 | Role of second messengers in netrin-1 signaling | 1.229760e-01 | 0.910 |
R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 1.301431e-01 | 0.886 |
R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 1.512974e-01 | 0.820 |
R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 2.181921e-01 | 0.661 |
R-HSA-933542 | TRAF6 mediated NF-kB activation | 2.181921e-01 | 0.661 |
R-HSA-72689 | Formation of a pool of free 40S subunits | 2.160025e-01 | 0.666 |
R-HSA-156842 | Eukaryotic Translation Elongation | 2.040548e-01 | 0.690 |
R-HSA-9006925 | Intracellular signaling by second messengers | 1.773198e-01 | 0.751 |
R-HSA-375165 | NCAM signaling for neurite out-growth | 1.130524e-01 | 0.947 |
R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 1.011212e-01 | 0.995 |
R-HSA-418359 | Reduction of cytosolic Ca++ levels | 1.157503e-01 | 0.936 |
R-HSA-9018681 | Biosynthesis of protectins | 1.372520e-01 | 0.862 |
R-HSA-5218921 | VEGFR2 mediated cell proliferation | 2.245867e-01 | 0.649 |
R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 1.745766e-01 | 0.758 |
R-HSA-69306 | DNA Replication | 1.661422e-01 | 0.780 |
R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 8.625190e-02 | 1.064 |
R-HSA-9932451 | SWI/SNF chromatin remodelers | 2.245867e-01 | 0.649 |
R-HSA-9932444 | ATP-dependent chromatin remodelers | 2.245867e-01 | 0.649 |
R-HSA-198753 | ERK/MAPK targets | 1.920865e-01 | 0.717 |
R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 1.701278e-01 | 0.769 |
R-HSA-114608 | Platelet degranulation | 1.120160e-01 | 0.951 |
R-HSA-426117 | Cation-coupled Chloride cotransporters | 7.872598e-02 | 1.104 |
R-HSA-425561 | Sodium/Calcium exchangers | 1.157503e-01 | 0.936 |
R-HSA-429947 | Deadenylation of mRNA | 2.181921e-01 | 0.661 |
R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 2.113633e-01 | 0.675 |
R-HSA-5693607 | Processing of DNA double-strand break ends | 1.658752e-01 | 0.780 |
R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 1.011212e-01 | 0.995 |
R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 1.243839e-01 | 0.905 |
R-HSA-5655291 | Signaling by FGFR4 in disease | 1.372520e-01 | 0.862 |
R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 1.372520e-01 | 0.862 |
R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 1.443033e-01 | 0.841 |
R-HSA-3270619 | IRF3-mediated induction of type I IFN | 1.443033e-01 | 0.841 |
R-HSA-9020265 | Biosynthesis of aspirin-triggered D-series resolvins | 1.651159e-01 | 0.782 |
R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 2.309293e-01 | 0.637 |
R-HSA-9764561 | Regulation of CDH1 Function | 1.000187e-01 | 1.000 |
R-HSA-1169408 | ISG15 antiviral mechanism | 1.487249e-01 | 0.828 |
R-HSA-9018676 | Biosynthesis of D-series resolvins | 2.052457e-01 | 0.688 |
R-HSA-140342 | Apoptosis induced DNA fragmentation | 1.011212e-01 | 0.995 |
R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 1.372520e-01 | 0.862 |
R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 1.651159e-01 | 0.782 |
R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 1.651159e-01 | 0.782 |
R-HSA-5653656 | Vesicle-mediated transport | 7.916567e-02 | 1.101 |
R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 1.986929e-01 | 0.702 |
R-HSA-5693532 | DNA Double-Strand Break Repair | 1.661422e-01 | 0.780 |
R-HSA-1483249 | Inositol phosphate metabolism | 8.264018e-02 | 1.083 |
R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 2.181921e-01 | 0.661 |
R-HSA-9659379 | Sensory processing of sound | 1.601187e-01 | 0.796 |
R-HSA-210990 | PECAM1 interactions | 1.084655e-01 | 0.965 |
R-HSA-9635465 | Suppression of apoptosis | 1.084655e-01 | 0.965 |
R-HSA-9856872 | Malate-aspartate shuttle | 1.372520e-01 | 0.862 |
R-HSA-9023661 | Biosynthesis of E-series 18(R)-resolvins | 1.372520e-01 | 0.862 |
R-HSA-1643713 | Signaling by EGFR in Cancer | 2.309293e-01 | 0.637 |
R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 1.292287e-01 | 0.889 |
R-HSA-168255 | Influenza Infection | 8.082130e-02 | 1.092 |
R-HSA-2028269 | Signaling by Hippo | 1.651159e-01 | 0.782 |
R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 1.719412e-01 | 0.765 |
R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 1.920865e-01 | 0.717 |
R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 1.920865e-01 | 0.717 |
R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 9.746602e-02 | 1.011 |
R-HSA-392499 | Metabolism of proteins | 1.337291e-01 | 0.874 |
R-HSA-430116 | GP1b-IX-V activation signalling | 9.371680e-02 | 1.028 |
R-HSA-9018896 | Biosynthesis of E-series 18(S)-resolvins | 1.920865e-01 | 0.717 |
R-HSA-9031628 | NGF-stimulated transcription | 7.777455e-02 | 1.109 |
R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 9.371680e-02 | 1.028 |
R-HSA-69620 | Cell Cycle Checkpoints | 1.950831e-01 | 0.710 |
R-HSA-5621575 | CD209 (DC-SIGN) signaling | 2.181921e-01 | 0.661 |
R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 2.309293e-01 | 0.637 |
R-HSA-69473 | G2/M DNA damage checkpoint | 1.459034e-01 | 0.836 |
R-HSA-210993 | Tie2 Signaling | 1.719412e-01 | 0.765 |
R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 2.052457e-01 | 0.688 |
R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 2.052457e-01 | 0.688 |
R-HSA-8983711 | OAS antiviral response | 1.229760e-01 | 0.910 |
R-HSA-156711 | Polo-like kinase mediated events | 1.719412e-01 | 0.765 |
R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 9.042620e-02 | 1.044 |
R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 7.777455e-02 | 1.109 |
R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 1.506354e-01 | 0.822 |
R-HSA-73894 | DNA Repair | 2.025475e-01 | 0.693 |
R-HSA-162582 | Signal Transduction | 1.581844e-01 | 0.801 |
R-HSA-3000171 | Non-integrin membrane-ECM interactions | 1.487249e-01 | 0.828 |
R-HSA-194138 | Signaling by VEGF | 1.085742e-01 | 0.964 |
R-HSA-9824446 | Viral Infection Pathways | 1.481020e-01 | 0.829 |
R-HSA-1834941 | STING mediated induction of host immune responses | 1.787110e-01 | 0.748 |
R-HSA-5663205 | Infectious disease | 1.630058e-01 | 0.788 |
R-HSA-168268 | Virus Assembly and Release | 1.512974e-01 | 0.820 |
R-HSA-112316 | Neuronal System | 1.083263e-01 | 0.965 |
R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 1.264956e-01 | 0.898 |
R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 1.833501e-01 | 0.737 |
R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 1.971905e-01 | 0.705 |
R-HSA-2682334 | EPH-Ephrin signaling | 2.040548e-01 | 0.690 |
R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 1.719412e-01 | 0.765 |
R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 2.052457e-01 | 0.688 |
R-HSA-3700989 | Transcriptional Regulation by TP53 | 1.057901e-01 | 0.976 |
R-HSA-2262752 | Cellular responses to stress | 2.329115e-01 | 0.633 |
R-HSA-2408557 | Selenocysteine synthesis | 2.340366e-01 | 0.631 |
R-HSA-1483255 | PI Metabolism | 2.370521e-01 | 0.625 |
R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 2.372204e-01 | 0.625 |
R-HSA-5655332 | Signaling by FGFR3 in disease | 2.372204e-01 | 0.625 |
R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 2.372204e-01 | 0.625 |
R-HSA-192823 | Viral mRNA Translation | 2.400698e-01 | 0.620 |
R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 2.430895e-01 | 0.614 |
R-HSA-171319 | Telomere Extension By Telomerase | 2.434605e-01 | 0.614 |
R-HSA-5620971 | Pyroptosis | 2.434605e-01 | 0.614 |
R-HSA-5673001 | RAF/MAP kinase cascade | 2.485028e-01 | 0.605 |
R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 2.496498e-01 | 0.603 |
R-HSA-9615710 | Late endosomal microautophagy | 2.496498e-01 | 0.603 |
R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 2.496498e-01 | 0.603 |
R-HSA-5656169 | Termination of translesion DNA synthesis | 2.496498e-01 | 0.603 |
R-HSA-5654708 | Downstream signaling of activated FGFR3 | 2.496498e-01 | 0.603 |
R-HSA-418360 | Platelet calcium homeostasis | 2.496498e-01 | 0.603 |
R-HSA-9006335 | Signaling by Erythropoietin | 2.496498e-01 | 0.603 |
R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 2.496498e-01 | 0.603 |
R-HSA-9018679 | Biosynthesis of EPA-derived SPMs | 2.496498e-01 | 0.603 |
R-HSA-72163 | mRNA Splicing - Major Pathway | 2.545132e-01 | 0.594 |
R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 2.551829e-01 | 0.593 |
R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 2.557890e-01 | 0.592 |
R-HSA-68962 | Activation of the pre-replicative complex | 2.557890e-01 | 0.592 |
R-HSA-2424491 | DAP12 signaling | 2.557890e-01 | 0.592 |
R-HSA-5654716 | Downstream signaling of activated FGFR4 | 2.557890e-01 | 0.592 |
R-HSA-1227990 | Signaling by ERBB2 in Cancer | 2.557890e-01 | 0.592 |
R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 2.582088e-01 | 0.588 |
R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 2.582088e-01 | 0.588 |
R-HSA-5684996 | MAPK1/MAPK3 signaling | 2.610004e-01 | 0.583 |
R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 2.618783e-01 | 0.582 |
R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 2.618783e-01 | 0.582 |
R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 2.618783e-01 | 0.582 |
R-HSA-162588 | Budding and maturation of HIV virion | 2.618783e-01 | 0.582 |
R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 2.618783e-01 | 0.582 |
R-HSA-186763 | Downstream signal transduction | 2.618783e-01 | 0.582 |
R-HSA-9833109 | Evasion by RSV of host interferon responses | 2.618783e-01 | 0.582 |
R-HSA-8963693 | Aspartate and asparagine metabolism | 2.618783e-01 | 0.582 |
R-HSA-202403 | TCR signaling | 2.642623e-01 | 0.578 |
R-HSA-69190 | DNA strand elongation | 2.679181e-01 | 0.572 |
R-HSA-111465 | Apoptotic cleavage of cellular proteins | 2.679181e-01 | 0.572 |
R-HSA-1855170 | IPs transport between nucleus and cytosol | 2.739089e-01 | 0.562 |
R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 2.739089e-01 | 0.562 |
R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 2.739089e-01 | 0.562 |
R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 2.763699e-01 | 0.559 |
R-HSA-72172 | mRNA Splicing | 2.787712e-01 | 0.555 |
R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 2.798510e-01 | 0.553 |
R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 2.798510e-01 | 0.553 |
R-HSA-5696394 | DNA Damage Recognition in GG-NER | 2.798510e-01 | 0.553 |
R-HSA-8964539 | Glutamate and glutamine metabolism | 2.798510e-01 | 0.553 |
R-HSA-5357801 | Programmed Cell Death | 2.809889e-01 | 0.551 |
R-HSA-909733 | Interferon alpha/beta signaling | 2.854450e-01 | 0.544 |
R-HSA-180746 | Nuclear import of Rev protein | 2.857449e-01 | 0.544 |
R-HSA-901042 | Calnexin/calreticulin cycle | 2.857449e-01 | 0.544 |
R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 2.857449e-01 | 0.544 |
R-HSA-72613 | Eukaryotic Translation Initiation | 2.884679e-01 | 0.540 |
R-HSA-72737 | Cap-dependent Translation Initiation | 2.884679e-01 | 0.540 |
R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 2.915908e-01 | 0.535 |
R-HSA-5654696 | Downstream signaling of activated FGFR2 | 2.915908e-01 | 0.535 |
R-HSA-5654687 | Downstream signaling of activated FGFR1 | 2.915908e-01 | 0.535 |
R-HSA-5693538 | Homology Directed Repair | 2.945095e-01 | 0.531 |
R-HSA-111933 | Calmodulin induced events | 2.973893e-01 | 0.527 |
R-HSA-111997 | CaM pathway | 2.973893e-01 | 0.527 |
R-HSA-68875 | Mitotic Prophase | 3.005444e-01 | 0.522 |
R-HSA-933541 | TRAF6 mediated IRF7 activation | 3.031407e-01 | 0.518 |
R-HSA-180910 | Vpr-mediated nuclear import of PICs | 3.031407e-01 | 0.518 |
R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 3.035588e-01 | 0.518 |
R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 3.088454e-01 | 0.510 |
R-HSA-9958790 | SLC-mediated transport of inorganic anions | 3.088454e-01 | 0.510 |
R-HSA-1643685 | Disease | 3.090750e-01 | 0.510 |
R-HSA-9816359 | Maternal to zygotic transition (MZT) | 3.095809e-01 | 0.509 |
R-HSA-168249 | Innate Immune System | 3.139052e-01 | 0.503 |
R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 3.145037e-01 | 0.502 |
R-HSA-451927 | Interleukin-2 family signaling | 3.201161e-01 | 0.495 |
R-HSA-202433 | Generation of second messenger molecules | 3.201161e-01 | 0.495 |
R-HSA-177243 | Interactions of Rev with host cellular proteins | 3.201161e-01 | 0.495 |
R-HSA-176033 | Interactions of Vpr with host cellular proteins | 3.201161e-01 | 0.495 |
R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 3.256828e-01 | 0.487 |
R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 3.256828e-01 | 0.487 |
R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 3.256828e-01 | 0.487 |
R-HSA-3000480 | Scavenging by Class A Receptors | 3.312043e-01 | 0.480 |
R-HSA-5655302 | Signaling by FGFR1 in disease | 3.312043e-01 | 0.480 |
R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 3.366809e-01 | 0.473 |
R-HSA-111996 | Ca-dependent events | 3.366809e-01 | 0.473 |
R-HSA-379716 | Cytosolic tRNA aminoacylation | 3.366809e-01 | 0.473 |
R-HSA-5654743 | Signaling by FGFR4 | 3.421130e-01 | 0.466 |
R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 3.421130e-01 | 0.466 |
R-HSA-2172127 | DAP12 interactions | 3.475010e-01 | 0.459 |
R-HSA-373752 | Netrin-1 signaling | 3.475010e-01 | 0.459 |
R-HSA-2142691 | Synthesis of Leukotrienes (LT) and Eoxins (EX) | 3.475010e-01 | 0.459 |
R-HSA-5683826 | Surfactant metabolism | 3.475010e-01 | 0.459 |
R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 3.528452e-01 | 0.452 |
R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 3.528452e-01 | 0.452 |
R-HSA-5654741 | Signaling by FGFR3 | 3.528452e-01 | 0.452 |
R-HSA-1614558 | Degradation of cysteine and homocysteine | 3.528452e-01 | 0.452 |
R-HSA-5683057 | MAPK family signaling cascades | 3.546582e-01 | 0.450 |
R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 3.581459e-01 | 0.446 |
R-HSA-8953897 | Cellular responses to stimuli | 3.596840e-01 | 0.444 |
R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 3.602391e-01 | 0.443 |
R-HSA-9948299 | Ribosome-associated quality control | 3.631812e-01 | 0.440 |
R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 3.634036e-01 | 0.440 |
R-HSA-381119 | Unfolded Protein Response (UPR) | 3.661183e-01 | 0.436 |
R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 3.686185e-01 | 0.433 |
R-HSA-425410 | Metal ion SLC transporters | 3.686185e-01 | 0.433 |
R-HSA-9664422 | FCGR3A-mediated phagocytosis | 3.690503e-01 | 0.433 |
R-HSA-9664407 | Parasite infection | 3.690503e-01 | 0.433 |
R-HSA-9664417 | Leishmania phagocytosis | 3.690503e-01 | 0.433 |
R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 3.719770e-01 | 0.429 |
R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 3.737910e-01 | 0.427 |
R-HSA-73893 | DNA Damage Bypass | 3.737910e-01 | 0.427 |
R-HSA-389661 | Glyoxylate metabolism and glycine degradation | 3.737910e-01 | 0.427 |
R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 3.778144e-01 | 0.423 |
R-HSA-162599 | Late Phase of HIV Life Cycle | 3.778144e-01 | 0.423 |
R-HSA-1280218 | Adaptive Immune System | 3.780109e-01 | 0.422 |
R-HSA-5655253 | Signaling by FGFR2 in disease | 3.789214e-01 | 0.421 |
R-HSA-9748787 | Azathioprine ADME | 3.789214e-01 | 0.421 |
R-HSA-8856828 | Clathrin-mediated endocytosis | 3.807249e-01 | 0.419 |
R-HSA-68949 | Orc1 removal from chromatin | 3.890575e-01 | 0.410 |
R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 3.890575e-01 | 0.410 |
R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 3.890575e-01 | 0.410 |
R-HSA-8948751 | Regulation of PTEN stability and activity | 3.940638e-01 | 0.404 |
R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 3.940638e-01 | 0.404 |
R-HSA-8956320 | Nucleotide biosynthesis | 3.940638e-01 | 0.404 |
R-HSA-9753281 | Paracetamol ADME | 4.039546e-01 | 0.394 |
R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 4.066527e-01 | 0.391 |
R-HSA-5654736 | Signaling by FGFR1 | 4.088397e-01 | 0.388 |
R-HSA-177929 | Signaling by EGFR | 4.088397e-01 | 0.388 |
R-HSA-5578775 | Ion homeostasis | 4.088397e-01 | 0.388 |
R-HSA-2980766 | Nuclear Envelope Breakdown | 4.136851e-01 | 0.383 |
R-HSA-5621480 | Dectin-2 family | 4.136851e-01 | 0.383 |
R-HSA-1483166 | Synthesis of PA | 4.136851e-01 | 0.383 |
R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 4.136851e-01 | 0.383 |
R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 4.184911e-01 | 0.378 |
R-HSA-9610379 | HCMV Late Events | 4.208341e-01 | 0.376 |
R-HSA-162587 | HIV Life Cycle | 4.208341e-01 | 0.376 |
R-HSA-194441 | Metabolism of non-coding RNA | 4.232580e-01 | 0.373 |
R-HSA-191859 | snRNP Assembly | 4.232580e-01 | 0.373 |
R-HSA-180786 | Extension of Telomeres | 4.232580e-01 | 0.373 |
R-HSA-429914 | Deadenylation-dependent mRNA decay | 4.232580e-01 | 0.373 |
R-HSA-9711097 | Cellular response to starvation | 4.236500e-01 | 0.373 |
R-HSA-877300 | Interferon gamma signaling | 4.264589e-01 | 0.370 |
R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 4.279861e-01 | 0.369 |
R-HSA-1227986 | Signaling by ERBB2 | 4.279861e-01 | 0.369 |
R-HSA-379724 | tRNA Aminoacylation | 4.279861e-01 | 0.369 |
R-HSA-5633007 | Regulation of TP53 Activity | 4.292607e-01 | 0.367 |
R-HSA-168325 | Viral Messenger RNA Synthesis | 4.326757e-01 | 0.364 |
R-HSA-450294 | MAP kinase activation | 4.326757e-01 | 0.364 |
R-HSA-112043 | PLC beta mediated events | 4.326757e-01 | 0.364 |
R-HSA-76002 | Platelet activation, signaling and aggregation | 4.338811e-01 | 0.363 |
R-HSA-109581 | Apoptosis | 4.348430e-01 | 0.362 |
R-HSA-6784531 | tRNA processing in the nucleus | 4.373272e-01 | 0.359 |
R-HSA-186797 | Signaling by PDGF | 4.373272e-01 | 0.359 |
R-HSA-1268020 | Mitochondrial protein import | 4.373272e-01 | 0.359 |
R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 4.373272e-01 | 0.359 |
R-HSA-2408522 | Selenoamino acid metabolism | 4.403963e-01 | 0.356 |
R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 4.419408e-01 | 0.355 |
R-HSA-373755 | Semaphorin interactions | 4.419408e-01 | 0.355 |
R-HSA-8848021 | Signaling by PTK6 | 4.419408e-01 | 0.355 |
R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 4.419408e-01 | 0.355 |
R-HSA-446728 | Cell junction organization | 4.424965e-01 | 0.354 |
R-HSA-9824443 | Parasitic Infection Pathways | 4.489256e-01 | 0.348 |
R-HSA-9658195 | Leishmania infection | 4.489256e-01 | 0.348 |
R-HSA-112040 | G-protein mediated events | 4.600228e-01 | 0.337 |
R-HSA-5621481 | C-type lectin receptors (CLRs) | 4.623084e-01 | 0.335 |
R-HSA-913709 | O-linked glycosylation of mucins | 4.644517e-01 | 0.333 |
R-HSA-5218859 | Regulated Necrosis | 4.644517e-01 | 0.333 |
R-HSA-74160 | Gene expression (Transcription) | 4.669767e-01 | 0.331 |
R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 4.677088e-01 | 0.330 |
R-HSA-9764265 | Regulation of CDH1 Expression and Function | 4.677088e-01 | 0.330 |
R-HSA-9678108 | SARS-CoV-1 Infection | 4.730774e-01 | 0.325 |
R-HSA-448424 | Interleukin-17 signaling | 4.732017e-01 | 0.325 |
R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 4.732017e-01 | 0.325 |
R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 4.775233e-01 | 0.321 |
R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 4.775233e-01 | 0.321 |
R-HSA-1257604 | PIP3 activates AKT signaling | 4.785232e-01 | 0.320 |
R-HSA-1483257 | Phospholipid metabolism | 4.785232e-01 | 0.320 |
R-HSA-5578749 | Transcriptional regulation by small RNAs | 4.818097e-01 | 0.317 |
R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 4.818097e-01 | 0.317 |
R-HSA-69052 | Switching of origins to a post-replicative state | 4.860613e-01 | 0.313 |
R-HSA-1226099 | Signaling by FGFR in disease | 4.902782e-01 | 0.310 |
R-HSA-8852135 | Protein ubiquitination | 4.944607e-01 | 0.306 |
R-HSA-5689603 | UCH proteinases | 4.986093e-01 | 0.302 |
R-HSA-5654738 | Signaling by FGFR2 | 5.148681e-01 | 0.288 |
R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 5.173718e-01 | 0.286 |
R-HSA-9018677 | Biosynthesis of DHA-derived SPMs | 5.188504e-01 | 0.285 |
R-HSA-1500931 | Cell-Cell communication | 5.214954e-01 | 0.283 |
R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 5.274340e-01 | 0.278 |
R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 5.306036e-01 | 0.275 |
R-HSA-1614635 | Sulfur amino acid metabolism | 5.420719e-01 | 0.266 |
R-HSA-376176 | Signaling by ROBO receptors | 5.447023e-01 | 0.264 |
R-HSA-70268 | Pyruvate metabolism | 5.458325e-01 | 0.263 |
R-HSA-73857 | RNA Polymerase II Transcription | 5.480598e-01 | 0.261 |
R-HSA-1236974 | ER-Phagosome pathway | 5.532620e-01 | 0.257 |
R-HSA-1266738 | Developmental Biology | 5.536545e-01 | 0.257 |
R-HSA-202424 | Downstream TCR signaling | 5.569314e-01 | 0.254 |
R-HSA-68867 | Assembly of the pre-replicative complex | 5.713123e-01 | 0.243 |
R-HSA-9837999 | Mitochondrial protein degradation | 5.748345e-01 | 0.240 |
R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 5.783280e-01 | 0.238 |
R-HSA-418990 | Adherens junctions interactions | 5.825158e-01 | 0.235 |
R-HSA-9694516 | SARS-CoV-2 Infection | 5.849790e-01 | 0.233 |
R-HSA-157579 | Telomere Maintenance | 5.886385e-01 | 0.230 |
R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 5.886385e-01 | 0.230 |
R-HSA-8951664 | Neddylation | 5.893463e-01 | 0.230 |
R-HSA-8957275 | Post-translational protein phosphorylation | 5.920195e-01 | 0.228 |
R-HSA-190236 | Signaling by FGFR | 5.920195e-01 | 0.228 |
R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 5.920195e-01 | 0.228 |
R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 5.920195e-01 | 0.228 |
R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 5.920195e-01 | 0.228 |
R-HSA-3214847 | HATs acetylate histones | 5.953728e-01 | 0.225 |
R-HSA-382556 | ABC-family proteins mediated transport | 5.986988e-01 | 0.223 |
R-HSA-162906 | HIV Infection | 6.027598e-01 | 0.220 |
R-HSA-9705683 | SARS-CoV-2-host interactions | 6.049633e-01 | 0.218 |
R-HSA-9842860 | Regulation of endogenous retroelements | 6.052696e-01 | 0.218 |
R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 6.052696e-01 | 0.218 |
R-HSA-111885 | Opioid Signalling | 6.117336e-01 | 0.213 |
R-HSA-449147 | Signaling by Interleukins | 6.140947e-01 | 0.212 |
R-HSA-9833110 | RSV-host interactions | 6.149261e-01 | 0.211 |
R-HSA-3247509 | Chromatin modifying enzymes | 6.179920e-01 | 0.209 |
R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 6.180926e-01 | 0.209 |
R-HSA-5696398 | Nucleotide Excision Repair | 6.180926e-01 | 0.209 |
R-HSA-9692914 | SARS-CoV-1-host interactions | 6.212332e-01 | 0.207 |
R-HSA-418346 | Platelet homeostasis | 6.212332e-01 | 0.207 |
R-HSA-15869 | Metabolism of nucleotides | 6.222618e-01 | 0.206 |
R-HSA-69239 | Synthesis of DNA | 6.243482e-01 | 0.205 |
R-HSA-211000 | Gene Silencing by RNA | 6.243482e-01 | 0.205 |
R-HSA-202733 | Cell surface interactions at the vascular wall | 6.243829e-01 | 0.205 |
R-HSA-1236975 | Antigen processing-Cross presentation | 6.274377e-01 | 0.202 |
R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 6.274377e-01 | 0.202 |
R-HSA-69002 | DNA Replication Pre-Initiation | 6.305021e-01 | 0.200 |
R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 6.305021e-01 | 0.200 |
R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 6.335414e-01 | 0.198 |
R-HSA-166166 | MyD88-independent TLR4 cascade | 6.335414e-01 | 0.198 |
R-HSA-2871796 | FCERI mediated MAPK activation | 6.395458e-01 | 0.194 |
R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 6.425113e-01 | 0.192 |
R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 6.483698e-01 | 0.188 |
R-HSA-4839726 | Chromatin organization | 6.491269e-01 | 0.188 |
R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 6.512632e-01 | 0.186 |
R-HSA-421270 | Cell-cell junction organization | 6.531242e-01 | 0.185 |
R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 6.541330e-01 | 0.184 |
R-HSA-2029485 | Role of phospholipids in phagocytosis | 6.541330e-01 | 0.184 |
R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 6.626025e-01 | 0.179 |
R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 6.653797e-01 | 0.177 |
R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 6.653797e-01 | 0.177 |
R-HSA-73886 | Chromosome Maintenance | 6.708662e-01 | 0.173 |
R-HSA-3371556 | Cellular response to heat stress | 6.708662e-01 | 0.173 |
R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 6.735759e-01 | 0.172 |
R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 6.735759e-01 | 0.172 |
R-HSA-162909 | Host Interactions of HIV factors | 6.789289e-01 | 0.168 |
R-HSA-69206 | G1/S Transition | 6.841949e-01 | 0.165 |
R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 6.867956e-01 | 0.163 |
R-HSA-199418 | Negative regulation of the PI3K/AKT network | 6.969878e-01 | 0.157 |
R-HSA-9679506 | SARS-CoV Infections | 6.985996e-01 | 0.156 |
R-HSA-5576891 | Cardiac conduction | 7.019597e-01 | 0.154 |
R-HSA-72766 | Translation | 7.167256e-01 | 0.145 |
R-HSA-5173105 | O-linked glycosylation | 7.187323e-01 | 0.143 |
R-HSA-9018678 | Biosynthesis of specialized proresolving mediators (SPMs) | 7.345678e-01 | 0.134 |
R-HSA-195721 | Signaling by WNT | 7.369860e-01 | 0.133 |
R-HSA-453279 | Mitotic G1 phase and G1/S transition | 7.410806e-01 | 0.130 |
R-HSA-69242 | S Phase | 7.453340e-01 | 0.128 |
R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 7.453340e-01 | 0.128 |
R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 7.495181e-01 | 0.125 |
R-HSA-9856651 | MITF-M-dependent gene expression | 7.495181e-01 | 0.125 |
R-HSA-9679191 | Potential therapeutics for SARS | 7.495181e-01 | 0.125 |
R-HSA-9755511 | KEAP1-NFE2L2 pathway | 7.515845e-01 | 0.124 |
R-HSA-212436 | Generic Transcription Pathway | 7.522380e-01 | 0.124 |
R-HSA-2142753 | Arachidonate metabolism | 7.536340e-01 | 0.123 |
R-HSA-9609507 | Protein localization | 7.556667e-01 | 0.122 |
R-HSA-9006936 | Signaling by TGFB family members | 7.694370e-01 | 0.114 |
R-HSA-5619102 | SLC transporter disorders | 7.824368e-01 | 0.107 |
R-HSA-1474244 | Extracellular matrix organization | 7.850883e-01 | 0.105 |
R-HSA-72306 | tRNA processing | 7.895359e-01 | 0.103 |
R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 7.947089e-01 | 0.100 |
R-HSA-9664433 | Leishmania parasite growth and survival | 7.947089e-01 | 0.100 |
R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 7.980707e-01 | 0.098 |
R-HSA-611105 | Respiratory electron transport | 8.030516e-01 | 0.095 |
R-HSA-201681 | TCF dependent signaling in response to WNT | 8.110577e-01 | 0.091 |
R-HSA-3781865 | Diseases of glycosylation | 8.126198e-01 | 0.090 |
R-HSA-168898 | Toll-like Receptor Cascades | 8.232009e-01 | 0.084 |
R-HSA-382551 | Transport of small molecules | 8.361974e-01 | 0.078 |
R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 8.399783e-01 | 0.076 |
R-HSA-1483206 | Glycerophospholipid biosynthesis | 8.399783e-01 | 0.076 |
R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 8.463428e-01 | 0.072 |
R-HSA-397014 | Muscle contraction | 8.527451e-01 | 0.069 |
R-HSA-9824439 | Bacterial Infection Pathways | 8.531375e-01 | 0.069 |
R-HSA-9730414 | MITF-M-regulated melanocyte development | 8.539648e-01 | 0.069 |
R-HSA-425407 | SLC-mediated transmembrane transport | 8.596595e-01 | 0.066 |
R-HSA-9748784 | Drug ADME | 8.599144e-01 | 0.066 |
R-HSA-5619115 | Disorders of transmembrane transporters | 8.899707e-01 | 0.051 |
R-HSA-71291 | Metabolism of amino acids and derivatives | 8.987304e-01 | 0.046 |
R-HSA-9711123 | Cellular response to chemical stress | 9.076499e-01 | 0.042 |
R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 9.178388e-01 | 0.037 |
R-HSA-212165 | Epigenetic regulation of gene expression | 9.416926e-01 | 0.026 |
R-HSA-418594 | G alpha (i) signalling events | 9.714438e-01 | 0.013 |
R-HSA-8978868 | Fatty acid metabolism | 9.714438e-01 | 0.013 |
R-HSA-5668914 | Diseases of metabolism | 9.758727e-01 | 0.011 |
R-HSA-388396 | GPCR downstream signalling | 9.987482e-01 | 0.001 |
R-HSA-556833 | Metabolism of lipids | 9.988077e-01 | 0.001 |
R-HSA-1430728 | Metabolism | 9.991564e-01 | 0.000 |
R-HSA-372790 | Signaling by GPCR | 9.993892e-01 | 0.000 |
R-HSA-9709957 | Sensory Perception | 9.997353e-01 | 0.000 |
Download
kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
---|---|---|---|---|
CDC7 |
0.830 | 0.370 | 1 | 0.867 |
COT |
0.825 | 0.096 | 2 | 0.790 |
MOS |
0.818 | 0.269 | 1 | 0.822 |
BMPR1B |
0.815 | 0.305 | 1 | 0.842 |
CLK3 |
0.812 | 0.099 | 1 | 0.704 |
PIM3 |
0.811 | 0.058 | -3 | 0.707 |
GRK1 |
0.811 | 0.169 | -2 | 0.766 |
GCN2 |
0.807 | -0.052 | 2 | 0.750 |
DSTYK |
0.806 | 0.007 | 2 | 0.795 |
NEK6 |
0.806 | 0.056 | -2 | 0.889 |
NDR2 |
0.806 | 0.039 | -3 | 0.718 |
PRPK |
0.805 | -0.041 | -1 | 0.794 |
TGFBR2 |
0.805 | 0.081 | -2 | 0.856 |
BMPR2 |
0.803 | 0.060 | -2 | 0.896 |
ULK2 |
0.803 | -0.054 | 2 | 0.744 |
IKKB |
0.802 | -0.078 | -2 | 0.737 |
RAF1 |
0.802 | -0.041 | 1 | 0.725 |
NEK7 |
0.801 | -0.011 | -3 | 0.797 |
GRK5 |
0.801 | 0.038 | -3 | 0.768 |
MST4 |
0.801 | 0.059 | 2 | 0.822 |
MTOR |
0.801 | -0.104 | 1 | 0.631 |
BMPR1A |
0.801 | 0.300 | 1 | 0.852 |
RSK2 |
0.800 | 0.039 | -3 | 0.640 |
FAM20C |
0.800 | 0.079 | 2 | 0.525 |
NLK |
0.800 | 0.009 | 1 | 0.651 |
TGFBR1 |
0.799 | 0.161 | -2 | 0.853 |
ACVR2B |
0.799 | 0.217 | -2 | 0.860 |
GRK6 |
0.799 | 0.088 | 1 | 0.780 |
GRK7 |
0.798 | 0.128 | 1 | 0.697 |
CAMK1B |
0.798 | -0.030 | -3 | 0.728 |
ATR |
0.798 | -0.030 | 1 | 0.688 |
ACVR2A |
0.798 | 0.184 | -2 | 0.851 |
ALK2 |
0.797 | 0.254 | -2 | 0.847 |
CAMK2G |
0.797 | -0.074 | 2 | 0.707 |
TBK1 |
0.796 | -0.114 | 1 | 0.601 |
PRKD1 |
0.796 | 0.023 | -3 | 0.686 |
PDHK4 |
0.796 | -0.214 | 1 | 0.707 |
SKMLCK |
0.795 | 0.009 | -2 | 0.850 |
ALK4 |
0.795 | 0.128 | -2 | 0.867 |
ERK5 |
0.795 | 0.000 | 1 | 0.648 |
PDHK1 |
0.795 | -0.119 | 1 | 0.688 |
PIM1 |
0.794 | 0.032 | -3 | 0.642 |
NDR1 |
0.794 | -0.018 | -3 | 0.696 |
KIS |
0.794 | -0.011 | 1 | 0.523 |
SRPK1 |
0.794 | 0.017 | -3 | 0.623 |
MAPKAPK2 |
0.794 | 0.040 | -3 | 0.581 |
DAPK2 |
0.794 | 0.036 | -3 | 0.741 |
BCKDK |
0.794 | -0.083 | -1 | 0.771 |
CDKL1 |
0.794 | -0.023 | -3 | 0.679 |
MARK4 |
0.793 | 0.019 | 4 | 0.871 |
IKKE |
0.793 | -0.118 | 1 | 0.600 |
NUAK2 |
0.793 | -0.013 | -3 | 0.708 |
IKKA |
0.793 | -0.013 | -2 | 0.736 |
WNK1 |
0.793 | -0.029 | -2 | 0.850 |
ATM |
0.793 | 0.006 | 1 | 0.667 |
CAMLCK |
0.792 | 0.002 | -2 | 0.834 |
GRK4 |
0.792 | -0.029 | -2 | 0.838 |
AMPKA1 |
0.792 | 0.023 | -3 | 0.714 |
MLK1 |
0.792 | -0.078 | 2 | 0.761 |
AURC |
0.792 | 0.069 | -2 | 0.639 |
PRKD2 |
0.792 | 0.012 | -3 | 0.628 |
NIK |
0.792 | -0.050 | -3 | 0.751 |
PKN3 |
0.792 | -0.050 | -3 | 0.690 |
ULK1 |
0.791 | -0.109 | -3 | 0.733 |
P90RSK |
0.791 | -0.011 | -3 | 0.641 |
CDKL5 |
0.791 | -0.003 | -3 | 0.664 |
RIPK3 |
0.790 | -0.071 | 3 | 0.669 |
P70S6KB |
0.790 | 0.004 | -3 | 0.654 |
RSK3 |
0.790 | -0.001 | -3 | 0.635 |
MAPKAPK3 |
0.790 | -0.015 | -3 | 0.623 |
CHAK2 |
0.789 | -0.043 | -1 | 0.736 |
HIPK4 |
0.789 | -0.007 | 1 | 0.616 |
PLK1 |
0.789 | 0.025 | -2 | 0.861 |
LATS2 |
0.789 | -0.024 | -5 | 0.670 |
HUNK |
0.789 | -0.093 | 2 | 0.733 |
SRPK2 |
0.789 | 0.014 | -3 | 0.545 |
NEK9 |
0.788 | -0.051 | 2 | 0.796 |
TSSK2 |
0.788 | 0.038 | -5 | 0.729 |
PKN2 |
0.788 | -0.048 | -3 | 0.698 |
PKCD |
0.787 | -0.015 | 2 | 0.732 |
TSSK1 |
0.787 | 0.037 | -3 | 0.735 |
CAMK2B |
0.787 | 0.018 | 2 | 0.675 |
AMPKA2 |
0.787 | 0.015 | -3 | 0.679 |
CAMK2D |
0.786 | -0.059 | -3 | 0.698 |
CK2A2 |
0.785 | 0.167 | 1 | 0.731 |
RSK4 |
0.785 | 0.035 | -3 | 0.617 |
LATS1 |
0.784 | 0.044 | -3 | 0.736 |
ANKRD3 |
0.784 | -0.115 | 1 | 0.698 |
NIM1 |
0.784 | -0.033 | 3 | 0.690 |
WNK3 |
0.784 | -0.152 | 1 | 0.657 |
PKACG |
0.784 | -0.027 | -2 | 0.711 |
SRPK3 |
0.783 | 0.001 | -3 | 0.603 |
MLK3 |
0.783 | -0.035 | 2 | 0.693 |
IRE1 |
0.782 | -0.069 | 1 | 0.631 |
MLK2 |
0.782 | -0.085 | 2 | 0.776 |
SMG1 |
0.782 | 0.031 | 1 | 0.635 |
MNK2 |
0.782 | -0.004 | -2 | 0.781 |
CAMK2A |
0.782 | -0.004 | 2 | 0.678 |
TTBK2 |
0.782 | -0.120 | 2 | 0.649 |
PKR |
0.782 | 0.014 | 1 | 0.684 |
TLK2 |
0.781 | -0.012 | 1 | 0.661 |
PAK1 |
0.781 | -0.021 | -2 | 0.773 |
DLK |
0.781 | -0.159 | 1 | 0.702 |
ICK |
0.780 | -0.055 | -3 | 0.709 |
CLK2 |
0.780 | 0.059 | -3 | 0.607 |
MASTL |
0.780 | -0.226 | -2 | 0.805 |
AURB |
0.780 | 0.033 | -2 | 0.640 |
PLK3 |
0.779 | -0.015 | 2 | 0.666 |
CDK8 |
0.779 | -0.050 | 1 | 0.507 |
PKCB |
0.779 | -0.026 | 2 | 0.692 |
CDK1 |
0.779 | -0.006 | 1 | 0.490 |
CLK1 |
0.779 | 0.017 | -3 | 0.602 |
NEK2 |
0.779 | -0.043 | 2 | 0.775 |
BRSK1 |
0.779 | -0.024 | -3 | 0.647 |
QSK |
0.779 | -0.000 | 4 | 0.849 |
CLK4 |
0.778 | 0.004 | -3 | 0.629 |
PKACB |
0.778 | 0.022 | -2 | 0.664 |
CDK5 |
0.778 | 0.007 | 1 | 0.534 |
PAK3 |
0.778 | -0.051 | -2 | 0.770 |
MELK |
0.778 | -0.029 | -3 | 0.654 |
PKCA |
0.778 | -0.021 | 2 | 0.688 |
MLK4 |
0.777 | -0.069 | 2 | 0.677 |
IRE2 |
0.777 | -0.050 | 2 | 0.730 |
YSK4 |
0.777 | -0.089 | 1 | 0.636 |
PKCG |
0.777 | -0.050 | 2 | 0.679 |
PRKD3 |
0.776 | -0.033 | -3 | 0.608 |
PERK |
0.776 | -0.008 | -2 | 0.848 |
CDK7 |
0.776 | -0.039 | 1 | 0.517 |
PKG2 |
0.776 | 0.012 | -2 | 0.645 |
VRK2 |
0.776 | -0.076 | 1 | 0.713 |
DYRK2 |
0.776 | -0.038 | 1 | 0.545 |
AURA |
0.776 | 0.020 | -2 | 0.625 |
SIK |
0.775 | -0.023 | -3 | 0.622 |
MARK3 |
0.775 | 0.018 | 4 | 0.820 |
MSK2 |
0.775 | -0.059 | -3 | 0.610 |
GRK2 |
0.775 | -0.025 | -2 | 0.727 |
SGK3 |
0.775 | -0.003 | -3 | 0.624 |
PHKG1 |
0.775 | -0.075 | -3 | 0.679 |
RIPK1 |
0.775 | -0.203 | 1 | 0.654 |
MEK1 |
0.775 | -0.117 | 2 | 0.765 |
NUAK1 |
0.774 | -0.056 | -3 | 0.643 |
QIK |
0.774 | -0.081 | -3 | 0.706 |
CK1E |
0.774 | -0.011 | -3 | 0.523 |
CAMK4 |
0.774 | -0.114 | -3 | 0.671 |
PAK6 |
0.774 | 0.005 | -2 | 0.673 |
MNK1 |
0.774 | -0.014 | -2 | 0.786 |
MSK1 |
0.774 | -0.016 | -3 | 0.608 |
CK2A1 |
0.774 | 0.134 | 1 | 0.703 |
CDK18 |
0.773 | -0.017 | 1 | 0.448 |
MYLK4 |
0.773 | -0.020 | -2 | 0.758 |
CDK19 |
0.773 | -0.050 | 1 | 0.473 |
PIM2 |
0.773 | 0.007 | -3 | 0.606 |
DCAMKL1 |
0.773 | -0.013 | -3 | 0.645 |
AKT2 |
0.773 | 0.002 | -3 | 0.557 |
CDK13 |
0.772 | -0.046 | 1 | 0.489 |
DNAPK |
0.772 | -0.046 | 1 | 0.570 |
CDK2 |
0.772 | -0.017 | 1 | 0.561 |
JNK2 |
0.772 | 0.003 | 1 | 0.464 |
HRI |
0.772 | -0.072 | -2 | 0.878 |
DRAK1 |
0.772 | -0.060 | 1 | 0.678 |
PKCH |
0.772 | -0.061 | 2 | 0.683 |
PLK4 |
0.772 | -0.069 | 2 | 0.593 |
BRAF |
0.772 | -0.002 | -4 | 0.745 |
JNK3 |
0.772 | -0.018 | 1 | 0.500 |
CDK3 |
0.771 | 0.027 | 1 | 0.431 |
PRKX |
0.771 | 0.023 | -3 | 0.551 |
BRSK2 |
0.771 | -0.066 | -3 | 0.661 |
MARK2 |
0.771 | -0.006 | 4 | 0.781 |
PAK2 |
0.771 | -0.057 | -2 | 0.754 |
CHAK1 |
0.769 | -0.120 | 2 | 0.725 |
P38G |
0.769 | -0.021 | 1 | 0.404 |
TLK1 |
0.769 | -0.082 | -2 | 0.888 |
P38A |
0.768 | -0.028 | 1 | 0.533 |
SSTK |
0.768 | 0.045 | 4 | 0.842 |
CDK17 |
0.768 | -0.031 | 1 | 0.410 |
PKCZ |
0.768 | -0.091 | 2 | 0.736 |
HIPK1 |
0.768 | -0.017 | 1 | 0.549 |
ERK1 |
0.767 | -0.029 | 1 | 0.464 |
MST3 |
0.767 | -0.012 | 2 | 0.782 |
HIPK2 |
0.767 | -0.018 | 1 | 0.459 |
P38B |
0.767 | -0.017 | 1 | 0.482 |
GRK3 |
0.767 | -0.010 | -2 | 0.691 |
NEK5 |
0.766 | -0.053 | 1 | 0.667 |
ZAK |
0.766 | -0.109 | 1 | 0.639 |
CHK1 |
0.766 | -0.068 | -3 | 0.684 |
PRP4 |
0.766 | -0.014 | -3 | 0.684 |
MEKK2 |
0.766 | -0.098 | 2 | 0.763 |
EEF2K |
0.765 | 0.090 | 3 | 0.799 |
MARK1 |
0.765 | -0.037 | 4 | 0.832 |
CDK12 |
0.765 | -0.051 | 1 | 0.463 |
CK1G1 |
0.765 | -0.052 | -3 | 0.514 |
MEKK3 |
0.765 | -0.166 | 1 | 0.656 |
CDK16 |
0.764 | 0.000 | 1 | 0.424 |
SNRK |
0.764 | -0.145 | 2 | 0.646 |
TAO3 |
0.763 | -0.058 | 1 | 0.641 |
P70S6K |
0.763 | -0.025 | -3 | 0.568 |
MEKK1 |
0.762 | -0.154 | 1 | 0.653 |
CK1D |
0.762 | -0.023 | -3 | 0.472 |
DAPK3 |
0.762 | 0.029 | -3 | 0.658 |
MEK5 |
0.762 | -0.217 | 2 | 0.770 |
WNK4 |
0.762 | -0.104 | -2 | 0.838 |
PKACA |
0.762 | -0.002 | -2 | 0.607 |
MPSK1 |
0.761 | 0.007 | 1 | 0.606 |
CDK9 |
0.761 | -0.069 | 1 | 0.494 |
AKT1 |
0.761 | -0.001 | -3 | 0.569 |
ERK2 |
0.761 | -0.064 | 1 | 0.497 |
CAMK1G |
0.761 | -0.087 | -3 | 0.615 |
PASK |
0.761 | -0.044 | -3 | 0.746 |
MAPKAPK5 |
0.760 | -0.133 | -3 | 0.574 |
IRAK4 |
0.759 | -0.102 | 1 | 0.635 |
GSK3A |
0.759 | 0.009 | 4 | 0.483 |
CK1A2 |
0.759 | -0.034 | -3 | 0.471 |
SMMLCK |
0.759 | -0.063 | -3 | 0.678 |
DYRK1A |
0.759 | -0.053 | 1 | 0.559 |
GSK3B |
0.758 | -0.007 | 4 | 0.475 |
PINK1 |
0.758 | -0.158 | 1 | 0.639 |
PKCT |
0.758 | -0.074 | 2 | 0.696 |
TAO2 |
0.757 | -0.056 | 2 | 0.788 |
CDK14 |
0.757 | -0.035 | 1 | 0.484 |
MST2 |
0.757 | -0.053 | 1 | 0.678 |
PHKG2 |
0.757 | -0.083 | -3 | 0.648 |
CDK10 |
0.757 | -0.016 | 1 | 0.472 |
DCAMKL2 |
0.757 | -0.085 | -3 | 0.663 |
GAK |
0.757 | -0.024 | 1 | 0.694 |
NEK8 |
0.756 | -0.121 | 2 | 0.770 |
TTBK1 |
0.756 | -0.137 | 2 | 0.566 |
TNIK |
0.756 | 0.018 | 3 | 0.803 |
DAPK1 |
0.756 | 0.014 | -3 | 0.646 |
P38D |
0.756 | -0.021 | 1 | 0.418 |
DYRK4 |
0.755 | -0.049 | 1 | 0.480 |
PLK2 |
0.755 | 0.004 | -3 | 0.746 |
ERK7 |
0.754 | -0.005 | 2 | 0.513 |
CAMKK1 |
0.754 | -0.119 | -2 | 0.718 |
DYRK1B |
0.754 | -0.055 | 1 | 0.503 |
AKT3 |
0.754 | 0.010 | -3 | 0.498 |
PKCE |
0.754 | -0.026 | 2 | 0.674 |
HIPK3 |
0.754 | -0.065 | 1 | 0.532 |
CAMKK2 |
0.754 | -0.090 | -2 | 0.707 |
PAK5 |
0.754 | -0.039 | -2 | 0.636 |
HGK |
0.753 | -0.022 | 3 | 0.791 |
GCK |
0.753 | -0.060 | 1 | 0.661 |
CAMK1D |
0.753 | -0.048 | -3 | 0.532 |
TAK1 |
0.753 | -0.040 | 1 | 0.692 |
PKCI |
0.752 | -0.072 | 2 | 0.708 |
JNK1 |
0.752 | -0.029 | 1 | 0.464 |
MINK |
0.752 | -0.039 | 1 | 0.639 |
DYRK3 |
0.752 | -0.051 | 1 | 0.553 |
PAK4 |
0.751 | -0.031 | -2 | 0.643 |
SGK1 |
0.751 | -0.002 | -3 | 0.478 |
NEK11 |
0.750 | -0.195 | 1 | 0.640 |
MEKK6 |
0.750 | -0.083 | 1 | 0.645 |
LKB1 |
0.749 | -0.102 | -3 | 0.739 |
MAK |
0.749 | 0.015 | -2 | 0.690 |
NEK4 |
0.749 | -0.105 | 1 | 0.626 |
PDK1 |
0.749 | -0.125 | 1 | 0.642 |
MRCKA |
0.748 | 0.005 | -3 | 0.601 |
HPK1 |
0.748 | -0.055 | 1 | 0.641 |
MRCKB |
0.747 | 0.005 | -3 | 0.590 |
CDK6 |
0.747 | -0.022 | 1 | 0.459 |
MAP3K15 |
0.747 | -0.107 | 1 | 0.613 |
VRK1 |
0.747 | -0.086 | 2 | 0.779 |
NEK1 |
0.747 | -0.050 | 1 | 0.635 |
ROCK2 |
0.747 | 0.009 | -3 | 0.640 |
KHS2 |
0.745 | -0.005 | 1 | 0.638 |
LOK |
0.745 | -0.063 | -2 | 0.750 |
KHS1 |
0.745 | -0.024 | 1 | 0.629 |
IRAK1 |
0.745 | -0.239 | -1 | 0.710 |
MST1 |
0.745 | -0.109 | 1 | 0.645 |
PKN1 |
0.744 | -0.073 | -3 | 0.579 |
LRRK2 |
0.744 | -0.146 | 2 | 0.789 |
OSR1 |
0.743 | -0.022 | 2 | 0.765 |
BUB1 |
0.743 | 0.027 | -5 | 0.649 |
TTK |
0.743 | 0.025 | -2 | 0.881 |
PDHK3_TYR |
0.742 | 0.129 | 4 | 0.895 |
YSK1 |
0.742 | -0.056 | 2 | 0.779 |
CDK4 |
0.742 | -0.038 | 1 | 0.450 |
MEK2 |
0.741 | -0.129 | 2 | 0.762 |
CAMK1A |
0.741 | -0.050 | -3 | 0.512 |
MOK |
0.741 | -0.012 | 1 | 0.565 |
EPHA6 |
0.739 | 0.178 | -1 | 0.838 |
PBK |
0.739 | -0.034 | 1 | 0.619 |
CHK2 |
0.739 | -0.075 | -3 | 0.494 |
STK33 |
0.738 | -0.156 | 2 | 0.554 |
SBK |
0.738 | -0.032 | -3 | 0.436 |
SLK |
0.736 | -0.121 | -2 | 0.707 |
EPHB4 |
0.735 | 0.139 | -1 | 0.838 |
DMPK1 |
0.734 | -0.005 | -3 | 0.615 |
RIPK2 |
0.733 | -0.223 | 1 | 0.593 |
TESK1_TYR |
0.733 | -0.039 | 3 | 0.803 |
TXK |
0.733 | 0.175 | 1 | 0.783 |
MAP2K4_TYR |
0.733 | -0.005 | -1 | 0.820 |
ROCK1 |
0.733 | -0.013 | -3 | 0.599 |
CRIK |
0.732 | 0.001 | -3 | 0.570 |
NEK3 |
0.731 | -0.110 | 1 | 0.590 |
ALPHAK3 |
0.731 | 0.049 | -1 | 0.719 |
PDHK4_TYR |
0.731 | -0.021 | 2 | 0.789 |
MAP2K6_TYR |
0.731 | -0.044 | -1 | 0.813 |
PKG1 |
0.730 | -0.050 | -2 | 0.579 |
MYO3B |
0.730 | -0.043 | 2 | 0.788 |
BMPR2_TYR |
0.730 | -0.046 | -1 | 0.821 |
PKMYT1_TYR |
0.729 | -0.057 | 3 | 0.769 |
BIKE |
0.729 | -0.013 | 1 | 0.581 |
PDHK1_TYR |
0.729 | -0.058 | -1 | 0.825 |
CK1A |
0.729 | -0.054 | -3 | 0.398 |
MAP2K7_TYR |
0.728 | -0.171 | 2 | 0.783 |
BLK |
0.727 | 0.144 | -1 | 0.817 |
MYO3A |
0.727 | -0.068 | 1 | 0.623 |
HASPIN |
0.726 | -0.074 | -1 | 0.577 |
SRMS |
0.726 | 0.130 | 1 | 0.807 |
HCK |
0.726 | 0.093 | -1 | 0.823 |
PINK1_TYR |
0.726 | -0.173 | 1 | 0.690 |
EPHB2 |
0.726 | 0.145 | -1 | 0.827 |
LCK |
0.725 | 0.110 | -1 | 0.818 |
ASK1 |
0.725 | -0.130 | 1 | 0.607 |
EPHB1 |
0.725 | 0.106 | 1 | 0.793 |
LIMK2_TYR |
0.725 | -0.034 | -3 | 0.766 |
EPHA4 |
0.725 | 0.106 | 2 | 0.658 |
TAO1 |
0.725 | -0.096 | 1 | 0.569 |
YES1 |
0.724 | 0.035 | -1 | 0.807 |
TYRO3 |
0.724 | 0.018 | 3 | 0.700 |
ABL2 |
0.724 | 0.025 | -1 | 0.780 |
FER |
0.724 | 0.058 | 1 | 0.810 |
EPHB3 |
0.724 | 0.115 | -1 | 0.835 |
YANK3 |
0.723 | -0.080 | 2 | 0.342 |
ROS1 |
0.722 | -0.012 | 3 | 0.665 |
RET |
0.721 | -0.117 | 1 | 0.644 |
ABL1 |
0.721 | 0.019 | -1 | 0.775 |
TEC |
0.721 | 0.105 | -1 | 0.764 |
TYK2 |
0.721 | -0.124 | 1 | 0.650 |
EPHA7 |
0.720 | 0.110 | 2 | 0.671 |
MST1R |
0.720 | -0.098 | 3 | 0.718 |
FGR |
0.719 | -0.065 | 1 | 0.718 |
MERTK |
0.719 | 0.077 | 3 | 0.674 |
ITK |
0.719 | 0.042 | -1 | 0.802 |
BMX |
0.719 | 0.060 | -1 | 0.738 |
STLK3 |
0.718 | -0.135 | 1 | 0.602 |
FYN |
0.718 | 0.067 | -1 | 0.789 |
CSF1R |
0.717 | -0.077 | 3 | 0.696 |
TNK2 |
0.717 | 0.014 | 3 | 0.667 |
LIMK1_TYR |
0.717 | -0.174 | 2 | 0.795 |
JAK2 |
0.717 | -0.121 | 1 | 0.640 |
DDR1 |
0.716 | -0.124 | 4 | 0.840 |
FRK |
0.716 | 0.083 | -1 | 0.837 |
TNNI3K_TYR |
0.714 | -0.023 | 1 | 0.650 |
BTK |
0.713 | 0.009 | -1 | 0.782 |
INSRR |
0.713 | -0.079 | 3 | 0.643 |
AAK1 |
0.713 | 0.012 | 1 | 0.483 |
JAK3 |
0.713 | -0.125 | 1 | 0.641 |
EPHA1 |
0.713 | 0.059 | 3 | 0.662 |
EPHA5 |
0.713 | 0.092 | 2 | 0.645 |
AXL |
0.712 | -0.012 | 3 | 0.676 |
PTK6 |
0.712 | -0.032 | -1 | 0.721 |
EPHA3 |
0.711 | -0.014 | 2 | 0.642 |
LTK |
0.710 | -0.017 | 3 | 0.639 |
LYN |
0.710 | 0.033 | 3 | 0.632 |
JAK1 |
0.710 | -0.060 | 1 | 0.595 |
TEK |
0.709 | -0.024 | 3 | 0.633 |
WEE1_TYR |
0.709 | -0.065 | -1 | 0.721 |
PTK2B |
0.709 | 0.036 | -1 | 0.772 |
KIT |
0.709 | -0.130 | 3 | 0.702 |
KDR |
0.709 | -0.110 | 3 | 0.662 |
ALK |
0.709 | -0.033 | 3 | 0.608 |
FGFR2 |
0.708 | -0.140 | 3 | 0.699 |
CK1G3 |
0.708 | -0.064 | -3 | 0.359 |
PDGFRB |
0.708 | -0.159 | 3 | 0.707 |
FLT3 |
0.708 | -0.121 | 3 | 0.696 |
EPHA8 |
0.707 | 0.017 | -1 | 0.810 |
MET |
0.706 | -0.095 | 3 | 0.682 |
SYK |
0.706 | 0.080 | -1 | 0.756 |
NEK10_TYR |
0.706 | -0.107 | 1 | 0.520 |
SRC |
0.704 | -0.016 | -1 | 0.784 |
FGFR1 |
0.702 | -0.149 | 3 | 0.667 |
ERBB2 |
0.702 | -0.131 | 1 | 0.647 |
PDGFRA |
0.702 | -0.176 | 3 | 0.710 |
TNK1 |
0.702 | -0.129 | 3 | 0.677 |
NTRK1 |
0.701 | -0.154 | -1 | 0.783 |
PTK2 |
0.700 | 0.006 | -1 | 0.770 |
FLT1 |
0.700 | -0.147 | -1 | 0.796 |
NTRK2 |
0.699 | -0.157 | 3 | 0.659 |
INSR |
0.698 | -0.133 | 3 | 0.626 |
FGFR3 |
0.698 | -0.148 | 3 | 0.673 |
EGFR |
0.698 | -0.072 | 1 | 0.574 |
EPHA2 |
0.697 | 0.015 | -1 | 0.793 |
NTRK3 |
0.697 | -0.122 | -1 | 0.742 |
MATK |
0.696 | -0.107 | -1 | 0.680 |
DDR2 |
0.695 | -0.087 | 3 | 0.637 |
FLT4 |
0.694 | -0.191 | 3 | 0.665 |
CSK |
0.692 | -0.124 | 2 | 0.678 |
YANK2 |
0.691 | -0.100 | 2 | 0.354 |
ERBB4 |
0.690 | -0.041 | 1 | 0.635 |
MUSK |
0.690 | -0.100 | 1 | 0.558 |
CK1G2 |
0.689 | -0.067 | -3 | 0.442 |
FGFR4 |
0.688 | -0.122 | -1 | 0.743 |
IGF1R |
0.684 | -0.131 | 3 | 0.563 |
FES |
0.684 | -0.034 | -1 | 0.706 |
ZAP70 |
0.671 | -0.070 | -1 | 0.673 |