Motif 869 (n=110)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A7E2V4 | ZSWIM8 | S598 | ochoa | Zinc finger SWIM domain-containing protein 8 | Substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex that promotes target-directed microRNA degradation (TDMD), a process that mediates degradation of microRNAs (miRNAs) (PubMed:33184234, PubMed:33184237). The SCF-like E3 ubiquitin-protein ligase complex acts by catalyzing ubiquitination and subsequent degradation of AGO proteins (AGO1, AGO2, AGO3 and/or AGO4), thereby exposing miRNAs for degradation (PubMed:33184234, PubMed:33184237). Specifically recognizes and binds AGO proteins when they are engaged with a TDMD target (PubMed:33184234). May also act as a regulator of axon guidance: specifically recognizes misfolded ROBO3 and promotes its ubiquitination and subsequent degradation (PubMed:24012004). Plays an essential role for proper embryonic development of heart and lung (By similarity). Controls protein quality of DAB1, a key signal molecule for brain development, thus protecting its signaling strength. Mechanistically, recognizes intrinsically disordered regions of DAB1 and eliminates misfolded DAB1 that cannot be properly phosphorylated (By similarity). {ECO:0000250|UniProtKB:Q3UHH1, ECO:0000269|PubMed:24012004, ECO:0000269|PubMed:33184234, ECO:0000269|PubMed:33184237}.; FUNCTION: (Microbial infection) Participates in Zika virus inhibition of IFN signaling by acting as a scaffold protein to connect ZSWIM8/CUL3 ligase complex and STAT2, leading to STAT2 degradation. {ECO:0000269|PubMed:39145933}. |
| O00170 | AIP | S132 | ochoa|psp | AH receptor-interacting protein (AIP) (Aryl-hydrocarbon receptor-interacting protein) (HBV X-associated protein 2) (XAP-2) (Immunophilin homolog ARA9) | May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.; FUNCTION: Cellular negative regulator of the hepatitis B virus (HBV) X protein. |
| O14646 | CHD1 | S1102 | ochoa | Chromodomain-helicase-DNA-binding protein 1 (CHD-1) (EC 3.6.4.-) (ATP-dependent helicase CHD1) | ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3 (PubMed:18042460, PubMed:28866611). Required for maintaining open chromatin and pluripotency in embryonic stem cells (By similarity). {ECO:0000250|UniProtKB:P40201, ECO:0000269|PubMed:18042460, ECO:0000269|PubMed:28866611}. |
| O14917 | PCDH17 | S1112 | ochoa | Protocadherin-17 (Protocadherin-68) | Potential calcium-dependent cell-adhesion protein. |
| O43194 | GPR39 | S384 | ochoa | G-protein coupled receptor 39 | Zinc-sensing receptor that can sense changes in extracellular Zn(2+), mediate Zn(2+) signal transmission, and participates in the regulation of numerous physiological processes including glucose homeostasis regulation, gastrointestinal mobility, hormone secretion and cell death (PubMed:18180304). Activation by Zn(2+) in keratinocytes increases the intracellular concentration of Ca(2+) and activates the ERK/MAPK and PI3K/AKT signaling pathways leading to epithelial repair (PubMed:20522546). Plays an essential role in normal wound healing by inducing the production of cytokines including the major inflammatory cytokine IL6 via the PKC/MAPK/CEBPB pathway (By similarity). Regulates adipose tissue metabolism, especially lipolysis, and regulates the function of lipases, such as hormone-sensitive lipase and adipose triglyceride lipase (By similarity). Plays a role in the inhibition of cell death and protects against oxidative, endoplasmic reticulum and mitochondrial stress by inducing secretion of the cytoprotective pigment epithelium-derived growth factor (PEDF) and probably other protective transcripts in a GNA13/RHOA/SRE-dependent manner (PubMed:18180304). Forms dynamic heteroreceptor complexes with HTR1A and GALR1 depending on cell type or specific physiological states, resulting in signaling diversity: HTR1A-GPR39 shows additive increase in signaling along the serum response element (SRE) and NF-kappa-B pathways while GALR1 acts as an antagonist blocking SRE (PubMed:26365466). {ECO:0000250|UniProtKB:Q5U431, ECO:0000269|PubMed:18180304, ECO:0000269|PubMed:20522546, ECO:0000269|PubMed:26365466}. |
| O43379 | WDR62 | S1232 | ochoa | WD repeat-containing protein 62 | Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (PubMed:20729831, PubMed:20890278). Plays a role in mother-centriole-dependent centriole duplication; the function also seems to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). {ECO:0000269|PubMed:20729831, ECO:0000269|PubMed:20890278, ECO:0000269|PubMed:26297806}. |
| O43524 | FOXO3 | S257 | ochoa | Forkhead box protein O3 (AF6q21 protein) (Forkhead in rhabdomyosarcoma-like 1) | Transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy (PubMed:10102273, PubMed:16751106, PubMed:21329882, PubMed:30513302). Acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, such as GABARAP1L, MAP1LC3B and ATG12, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins (By similarity). Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (PubMed:10102273, PubMed:16751106). Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (PubMed:21329882). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription. Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Also acts as a key regulator of regulatory T-cells (Treg) differentiation by activating expression of FOXP3 (PubMed:30513302). {ECO:0000250|UniProtKB:Q9WVH4, ECO:0000269|PubMed:10102273, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:21329882, ECO:0000269|PubMed:23283301, ECO:0000269|PubMed:30513302}. |
| O43752 | STX6 | S133 | ochoa | Syntaxin-6 | SNARE promoting movement of transport vesicles to target membranes. Targets endosomes to the trans-Golgi network, and may therefore function in retrograde trafficking. Together with SNARE STX12, promotes movement of vesicles from endosomes to the cell membrane, and may therefore function in the endocytic recycling pathway. {ECO:0000250|UniProtKB:Q63635}. |
| O43772 | SLC25A20 | S143 | ochoa | Mitochondrial carnitine/acylcarnitine carrier protein (Carnitine/acylcarnitine translocase) (CAC) (CACT) (Solute carrier family 25 member 20) | Mediates the electroneutral exchange of acylcarnitines (O-acyl-(R)-carnitine or L-acylcarnitine) of different acyl chain lengths (ranging from O-acetyl-(R)-carnitine to long-chain O-acyl-(R)-carnitines) with free carnitine ((R)-carnitine or L-carnitine) across the mitochondrial inner membrane, via a ping-pong mechanism (Probable) (PubMed:12892634, PubMed:18307102). Key player in the mitochondrial oxidation pathway, it translocates the fatty acids in the form of acylcarnitines into the mitochondrial matrix, where the carnitine palmitoyltransferase 2 (CPT-2) activates them to undergo fatty acid beta-oxidation (Probable). Catalyzes the unidirectional transport (uniport) of carnitine at lower rates than the antiport (exchange) (PubMed:18307102). {ECO:0000269|PubMed:12892634, ECO:0000269|PubMed:18307102, ECO:0000305|PubMed:18307102, ECO:0000305|PubMed:20347717}. |
| O60341 | KDM1A | S687 | psp | Lysine-specific histone demethylase 1A (EC 1.14.99.66) (BRAF35-HDAC complex protein BHC110) (Flavin-containing amine oxidase domain-containing protein 2) ([histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1A) | Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context (PubMed:15620353, PubMed:15811342, PubMed:16079794, PubMed:16079795, PubMed:16140033, PubMed:16223729, PubMed:27292636). Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed (PubMed:15620353, PubMed:15811342, PubMed:16079794, PubMed:21300290). Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me (PubMed:15620353, PubMed:20389281, PubMed:21300290, PubMed:23721412). May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity (PubMed:16079794, PubMed:16140033, PubMed:16885027, PubMed:21300290, PubMed:23721412). Also acts as a coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in AR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A (PubMed:16079795). Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1 (PubMed:29691401). Demethylates methylated 'Lys-42' and methylated 'Lys-117' of SOX2 (PubMed:29358331). Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (PubMed:16079794, PubMed:16140033). Facilitates epithelial-to-mesenchymal transition by acting as an effector of SNAI1-mediated transcription repression of epithelial markers E-cadherin/CDH1, CDN7 and KRT8 (PubMed:20562920, PubMed:27292636). Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7 (PubMed:20389281). Required for the repression of GIPR expression (PubMed:34655521, PubMed:34906447). {ECO:0000269|PubMed:12032298, ECO:0000269|PubMed:15620353, ECO:0000269|PubMed:15811342, ECO:0000269|PubMed:16079794, ECO:0000269|PubMed:16079795, ECO:0000269|PubMed:16140033, ECO:0000269|PubMed:16223729, ECO:0000269|PubMed:16885027, ECO:0000269|PubMed:16956976, ECO:0000269|PubMed:17805299, ECO:0000269|PubMed:20228790, ECO:0000269|PubMed:20389281, ECO:0000269|PubMed:20562920, ECO:0000269|PubMed:21300290, ECO:0000269|PubMed:23721412, ECO:0000269|PubMed:27292636, ECO:0000269|PubMed:29358331, ECO:0000269|PubMed:29691401, ECO:0000269|PubMed:34655521, ECO:0000269|PubMed:34906447}. |
| O75153 | CLUH | S723 | ochoa | Clustered mitochondria protein homolog | mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. Specifically binds mRNAs of nuclear-encoded mitochondrial proteins in the cytoplasm and regulates transport or translation of these transcripts close to mitochondria, playing a role in mitochondrial biogenesis. {ECO:0000255|HAMAP-Rule:MF_03013, ECO:0000269|PubMed:25349259}. |
| O75410 | TACC1 | S361 | ochoa | Transforming acidic coiled-coil-containing protein 1 (Gastric cancer antigen Ga55) (Taxin-1) | Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863). Might promote the nuclear localization of the receptors (PubMed:20078863). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. {ECO:0000269|PubMed:20078863}. |
| O75533 | SF3B1 | S35 | ochoa | Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B1 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). {ECO:0000250|UniProtKB:Q99NB9, ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}. |
| O75533 | SF3B1 | S75 | ochoa | Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B1 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). {ECO:0000250|UniProtKB:Q99NB9, ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}. |
| O75533 | SF3B1 | S322 | ochoa | Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B1 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). {ECO:0000250|UniProtKB:Q99NB9, ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}. |
| O95239 | KIF4A | S1126 | ochoa | Chromosome-associated kinesin KIF4A (Chromokinesin-A) | Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis (PubMed:29848660). Translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis (PubMed:15297875, PubMed:15625105). May play a role in mitotic chromosomal positioning and bipolar spindle stabilization (By similarity). {ECO:0000250|UniProtKB:P33174, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:29848660}. |
| O95831 | AIFM1 | S375 | ochoa | Apoptosis-inducing factor 1, mitochondrial (EC 1.6.99.-) (Programmed cell death protein 8) | Functions both as NADH oxidoreductase and as regulator of apoptosis (PubMed:17094969, PubMed:20362274, PubMed:23217327, PubMed:33168626). In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway (PubMed:20362274). Release into the cytoplasm is mediated upon binding to poly-ADP-ribose chains (By similarity). The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA (PubMed:20362274). Binds to DNA in a sequence-independent manner (PubMed:27178839). Interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates caspase-7 to amplify apoptosis (PubMed:17094969). Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells (PubMed:19418225). In contrast, participates in normal mitochondrial metabolism. Plays an important role in the regulation of respiratory chain biogenesis by interacting with CHCHD4 and controlling CHCHD4 mitochondrial import (PubMed:26004228). {ECO:0000250|UniProtKB:Q9Z0X1, ECO:0000269|PubMed:17094969, ECO:0000269|PubMed:19418225, ECO:0000269|PubMed:20362274, ECO:0000269|PubMed:23217327, ECO:0000269|PubMed:26004228, ECO:0000269|PubMed:27178839, ECO:0000269|PubMed:33168626}.; FUNCTION: [Isoform 4]: Has NADH oxidoreductase activity. Does not induce nuclear apoptosis. {ECO:0000269|PubMed:16644725}.; FUNCTION: [Isoform 5]: Pro-apoptotic isoform. {ECO:0000269|PubMed:16365034}. |
| P00441 | SOD1 | S60 | ochoa | Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) (Superoxide dismutase 1) (hSod1) | Destroys radicals which are normally produced within the cells and which are toxic to biological systems. {ECO:0000269|PubMed:24140062}. |
| P02042 | HBD | S73 | ochoa | Hemoglobin subunit delta (Delta-globin) (Hemoglobin delta chain) | Involved in oxygen transport from the lung to the various peripheral tissues. |
| P05023 | ATP1A1 | S635 | ochoa | Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-1) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (PubMed:29499166, PubMed:30388404). Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity). {ECO:0000250|UniProtKB:Q8VDN2, ECO:0000269|PubMed:29499166, ECO:0000269|PubMed:30388404}. |
| P05062 | ALDOB | S276 | ochoa | Fructose-bisphosphate aldolase B (EC 4.1.2.13) (Liver-type aldolase) | Catalyzes the aldol cleavage of fructose 1,6-biphosphate to form two triosephosphates dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate in glycolysis as well as the reverse stereospecific aldol addition reaction in gluconeogenesis. In fructolysis, metabolizes fructose 1-phosphate derived from the phosphorylation of dietary fructose by fructokinase into dihydroxyacetone phosphate and D-glyceraldehyde (PubMed:10970798, PubMed:12205126, PubMed:20848650). Acts as an adapter independently of its enzymatic activity, exerts a tumor suppressor role by stabilizing the ternary complex with G6PD and TP53 to inhibit G6PD activity and keep oxidative pentose phosphate metabolism in check (PubMed:35122041). {ECO:0000269|PubMed:10970798, ECO:0000269|PubMed:12205126, ECO:0000269|PubMed:20848650, ECO:0000269|PubMed:35122041}. |
| P10636 | MAPT | S288 | psp | Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}. |
| P13073 | COX4I1 | S30 | ochoa | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (Cytochrome c oxidase polypeptide IV) (Cytochrome c oxidase subunit IV isoform 1) (COX IV-1) | Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P00424}. |
| P13637 | ATP1A3 | S625 | ochoa | Sodium/potassium-transporting ATPase subunit alpha-3 (Na(+)/K(+) ATPase alpha-3 subunit) (EC 7.2.2.13) (Na(+)/K(+) ATPase alpha(III) subunit) (Sodium pump subunit alpha-3) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. {ECO:0000269|PubMed:33880529}. |
| P13639 | EEF2 | S422 | ochoa | Elongation factor 2 (EF-2) (EC 3.6.5.-) | Catalyzes the GTP-dependent ribosomal translocation step during translation elongation (PubMed:26593721). During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively (PubMed:26593721). Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (PubMed:26593721). {ECO:0000269|PubMed:26593721}. |
| P20340 | RAB6A | S23 | ochoa | Ras-related protein Rab-6A (Rab-6) (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:25962623). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:25962623). RAB6A acts as a regulator of COPI-independent retrograde transport from the Golgi apparatus towards the endoplasmic reticulum (ER) (PubMed:25962623). Has a low GTPase activity (PubMed:25962623). Recruits VPS13B to the Golgi membrane (PubMed:25492866). Plays a role in neuron projection development (Probable). {ECO:0000269|PubMed:25492866, ECO:0000269|PubMed:25962623, ECO:0000305|PubMed:25492866}. |
| P21359 | NF1 | S883 | ochoa | Neurofibromin (Neurofibromatosis-related protein NF-1) [Cleaved into: Neurofibromin truncated] | Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity. {ECO:0000269|PubMed:2121371, ECO:0000269|PubMed:8417346}. |
| P28290 | ITPRID2 | S1134 | ochoa | Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) | None |
| P33240 | CSTF2 | S524 | ochoa | Cleavage stimulation factor subunit 2 (CF-1 64 kDa subunit) (Cleavage stimulation factor 64 kDa subunit) (CSTF 64 kDa subunit) (CstF-64) | One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs. {ECO:0000269|PubMed:32816001, ECO:0000269|PubMed:9199325}. |
| P36871 | PGM1 | S509 | ochoa | Phosphoglucomutase-1 (PGM 1) (EC 5.4.2.2) (Glucose phosphomutase 1) | Catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate (PubMed:15378030, PubMed:25288802). The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate (Probable) (PubMed:25288802). This enzyme participates in both the breakdown and synthesis of glucose (PubMed:17924679, PubMed:25288802). {ECO:0000269|PubMed:15378030, ECO:0000269|PubMed:17924679, ECO:0000269|PubMed:25288802, ECO:0000305|PubMed:15378030}. |
| P36897 | TGFBR1 | S191 | psp | TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Activin A receptor type II-like protein kinase of 53kD) (Activin receptor-like kinase 5) (ALK-5) (ALK5) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I) | Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis (PubMed:33914044). The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation. {ECO:0000269|PubMed:15761148, ECO:0000269|PubMed:16754747, ECO:0000269|PubMed:18758450, ECO:0000269|PubMed:33914044, ECO:0000269|PubMed:7774578, ECO:0000269|PubMed:8752209, ECO:0000269|PubMed:8980228, ECO:0000269|PubMed:9346908}. |
| P46013 | MKI67 | S1302 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P48634 | PRRC2A | S1089 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P49327 | FASN | S523 | ochoa | Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] | Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269|PubMed:16215233, ECO:0000269|PubMed:16969344, ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
| P50993 | ATP1A2 | S632 | ochoa | Sodium/potassium-transporting ATPase subunit alpha-2 (Na(+)/K(+) ATPase alpha-2 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-2) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients. {ECO:0000269|PubMed:33880529}. |
| P61978 | HNRNPK | S81 | ochoa | Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP) | One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). {ECO:0000250, ECO:0000269|PubMed:16360036, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:22825850, ECO:0000269|PubMed:33174841}. |
| P68871 | HBB | S73 | ochoa | Hemoglobin subunit beta (Beta-globin) (Hemoglobin beta chain) [Cleaved into: LVV-hemorphin-7; Spinorphin] | Involved in oxygen transport from the lung to the various peripheral tissues. {ECO:0000269|PubMed:28066926}.; FUNCTION: LVV-hemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure.; FUNCTION: [Spinorphin]: Functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation. |
| P78368 | CSNK1G2 | S32 | ochoa | Casein kinase I isoform gamma-2 (CKI-gamma 2) (EC 2.7.11.1) | Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation (PubMed:15077195, PubMed:15917222, PubMed:18794808, PubMed:19005213). Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate (By similarity). Involved in regulation of reactive oxygen species (ROS) levels (PubMed:37099597). {ECO:0000250|UniProtKB:P48729, ECO:0000250|UniProtKB:Q8BVP5, ECO:0000269|PubMed:15077195, ECO:0000269|PubMed:15917222, ECO:0000269|PubMed:18794808, ECO:0000269|PubMed:19005213, ECO:0000269|PubMed:37099597}. |
| P84243 | H3-3A | S32 | ochoa | Histone H3.3 | Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15776021, ECO:0000269|PubMed:16258499}. |
| Q07912 | TNK2 | S856 | ochoa | Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Tyrosine kinase non-receptor protein 2) | Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR. Phosphorylates WASP (PubMed:20110370). {ECO:0000269|PubMed:10652228, ECO:0000269|PubMed:11278436, ECO:0000269|PubMed:16247015, ECO:0000269|PubMed:16257963, ECO:0000269|PubMed:16472662, ECO:0000269|PubMed:17038317, ECO:0000269|PubMed:18262180, ECO:0000269|PubMed:18435854, ECO:0000269|PubMed:19815557, ECO:0000269|PubMed:20110370, ECO:0000269|PubMed:20333297, ECO:0000269|PubMed:20383201}. |
| Q09666 | AHNAK | S337 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S3724 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S5397 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S5593 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S5832 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12774 | ARHGEF5 | S892 | ochoa | Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM) | Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity). {ECO:0000250|UniProtKB:E9Q7D5, ECO:0000269|PubMed:14662653, ECO:0000269|PubMed:15601624}. |
| Q13177 | PAK2 | S24 | ochoa | Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (Gamma-PAK) (PAK65) (S6/H4 kinase) (p21-activated kinase 2) (PAK-2) (p58) [Cleaved into: PAK-2p27 (p27); PAK-2p34 (p34) (C-t-PAK2)] | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation (PubMed:12853446, PubMed:16617111, PubMed:19273597, PubMed:19923322, PubMed:33693784, PubMed:7744004, PubMed:9171063). Acts as a downstream effector of the small GTPases CDC42 and RAC1 (PubMed:7744004). Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues (PubMed:7744004). Full-length PAK2 stimulates cell survival and cell growth (PubMed:7744004). Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration (PubMed:21317288). Phosphorylates JUN and plays an important role in EGF-induced cell proliferation (PubMed:21177766). Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP (PubMed:21724829). Phosphorylates CASP7, thereby preventing its activity (PubMed:21555521, PubMed:27889207). Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis (PubMed:19273597, PubMed:19923322). On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway (PubMed:12853446, PubMed:16617111, PubMed:9171063). Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation (PubMed:15234964). {ECO:0000269|PubMed:12853446, ECO:0000269|PubMed:15234964, ECO:0000269|PubMed:16617111, ECO:0000269|PubMed:19273597, ECO:0000269|PubMed:19923322, ECO:0000269|PubMed:21177766, ECO:0000269|PubMed:21317288, ECO:0000269|PubMed:21555521, ECO:0000269|PubMed:21724829, ECO:0000269|PubMed:27889207, ECO:0000269|PubMed:33693784, ECO:0000269|PubMed:7744004, ECO:0000269|PubMed:9171063}. |
| Q13526 | PIN1 | S42 | ochoa | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Peptidyl-prolyl cis-trans isomerase Pin1) (PPIase Pin1) (Rotamase Pin1) | Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs (PubMed:21497122, PubMed:23623683, PubMed:29686383). By inducing conformational changes in a subset of phosphorylated proteins, acts as a molecular switch in multiple cellular processes (PubMed:21497122, PubMed:22033920, PubMed:23623683). Displays a preference for acidic residues located N-terminally to the proline bond to be isomerized. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK (PubMed:16644721). Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation (PubMed:15664191). Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner (PubMed:17828269). Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN (PubMed:22608923). May facilitate the ubiquitination and proteasomal degradation of RBBP8/CtIP through CUL3/KLHL15 E3 ubiquitin-protein ligase complex, hence favors DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:23623683, PubMed:27561354). Upon IL33-induced lung inflammation, catalyzes cis-trans isomerization of phosphorylated IRAK3/IRAK-M, inducing IRAK3 stabilization, nuclear translocation and expression of pro-inflammatory genes in dendritic cells (PubMed:29686383). Catalyzes cis-trans isomerization of phosphorylated phosphoglycerate kinase PGK1 under hypoxic conditions to promote its binding to the TOM complex and targeting to the mitochondrion (PubMed:26942675). {ECO:0000269|PubMed:15664191, ECO:0000269|PubMed:16644721, ECO:0000269|PubMed:17828269, ECO:0000269|PubMed:21497122, ECO:0000269|PubMed:22033920, ECO:0000269|PubMed:22608923, ECO:0000269|PubMed:23623683, ECO:0000269|PubMed:26942675, ECO:0000269|PubMed:27561354, ECO:0000269|PubMed:29686383}. |
| Q13671 | RIN1 | S42 | ochoa | Ras and Rab interactor 1 (Ras inhibitor JC99) (Ras interaction/interference protein 1) | Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis. {ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9208849}. |
| Q14162 | SCARF1 | S610 | ochoa | Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I) | Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein. Plays a role in the regulation of neurite-like outgrowth (By similarity). {ECO:0000250}. |
| Q14162 | SCARF1 | S684 | ochoa | Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I) | Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein. Plays a role in the regulation of neurite-like outgrowth (By similarity). {ECO:0000250}. |
| Q14315 | FLNC | S2602 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q15084 | PDIA6 | Y252 | ochoa | Protein disulfide-isomerase A6 (EC 5.3.4.1) (Endoplasmic reticulum protein 5) (ER protein 5) (ERp5) (Protein disulfide isomerase P5) (Thioredoxin domain-containing protein 7) | May function as a chaperone that inhibits aggregation of misfolded proteins (PubMed:12204115). Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (PubMed:24508390). May also regulate the UPR via the EIF2AK3 UPR sensor (PubMed:24508390). Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (PubMed:15466936). {ECO:0000269|PubMed:12204115, ECO:0000269|PubMed:15466936, ECO:0000269|PubMed:24508390}. |
| Q15149 | PLEC | S1448 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q15773 | MLF2 | S32 | ochoa | Myeloid leukemia factor 2 (Myelodysplasia-myeloid leukemia factor 2) | None |
| Q29RF7 | PDS5A | S1159 | ochoa | Sister chromatid cohesion protein PDS5 homolog A (Cell proliferation-inducing gene 54 protein) (Sister chromatid cohesion protein 112) (SCC-112) | Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15855230, ECO:0000269|PubMed:19907496}. |
| Q2KJY2 | KIF26B | S274 | ochoa | Kinesin-like protein KIF26B | Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity). {ECO:0000250}. |
| Q3L8U1 | CHD9 | S1472 | ochoa | Chromodomain-helicase-DNA-binding protein 9 (CHD-9) (EC 3.6.4.-) (ATP-dependent helicase CHD9) (Chromatin-related mesenchymal modulator) (CReMM) (Chromatin-remodeling factor CHROM1) (Kismet homolog 2) (PPAR-alpha-interacting complex protein 320 kDa) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) | Probable ATP-dependent chromatin-remodeling factor. Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Has DNA-dependent ATPase activity and binds to A/T-rich DNA. Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis (By similarity). {ECO:0000250, ECO:0000269|PubMed:16095617, ECO:0000269|PubMed:16554032}. |
| Q58EX2 | SDK2 | S1982 | ochoa | Protein sidekick-2 | Adhesion molecule that promotes lamina-specific synaptic connections in the retina and is specifically required for the formation of neuronal circuits that detect motion. Acts by promoting formation of synapses between two specific retinal cell types: the retinal ganglion cells W3B-RGCs and the excitatory amacrine cells VG3-ACs. Formation of synapses between these two cells plays a key role in detection of motion. Promotes synaptic connectivity via homophilic interactions. {ECO:0000250|UniProtKB:Q6V4S5}. |
| Q5JSZ5 | PRRC2B | S1136 | ochoa | Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) | None |
| Q641Q2 | WASHC2A | S1123 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
| Q69YH5 | CDCA2 | S981 | psp | Cell division cycle-associated protein 2 (Recruits PP1 onto mitotic chromatin at anaphase protein) (Repo-Man) | Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. {ECO:0000269|PubMed:16492807, ECO:0000269|PubMed:16998479}. |
| Q6DCA0 | AMMECR1L | S33 | ochoa | AMMECR1-like protein | None |
| Q6P1M3 | LLGL2 | S965 | ochoa | LLGL scribble cell polarity complex component 2 (HGL) (Lethal(2) giant larvae protein homolog 2) | Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity. {ECO:0000269|PubMed:15632202}. |
| Q6PGQ7 | BORA | S339 | ochoa | Protein aurora borealis (HsBora) | Required for the activation of AURKA at the onset of mitosis. {ECO:0000269|PubMed:16890155}. |
| Q6ZNJ1 | NBEAL2 | S763 | ochoa | Neurobeachin-like protein 2 | Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis. {ECO:0000269|PubMed:21765411, ECO:0000269|PubMed:21765412}. |
| Q6ZSR9 | None | S258 | ochoa | Uncharacterized protein FLJ45252 | None |
| Q6ZV73 | FGD6 | S663 | ochoa | FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24) | May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity). {ECO:0000250}. |
| Q7L2J0 | MEPCE | S179 | ochoa | 7SK snRNA methylphosphate capping enzyme (MePCE) (EC 2.1.1.-) (Bicoid-interacting protein 3 homolog) (Bin3 homolog) | S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA), leading to stabilize it (PubMed:17643375, PubMed:19906723, PubMed:30559425). Also has a non-enzymatic function as part of the 7SK RNP complex: the 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:17643375). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate the assembly of 7SK RNP complex (PubMed:19906723, PubMed:38100593). MEPCE has a non-enzymatic function in the 7SK RNP complex; interaction with LARP7 within the 7SK RNP complex occluding its catalytic center (PubMed:19906723). Also required for stability of U6 snRNAs (PubMed:38100593). {ECO:0000269|PubMed:17643375, ECO:0000269|PubMed:19906723, ECO:0000269|PubMed:28254838, ECO:0000269|PubMed:30559425, ECO:0000269|PubMed:38100593}. |
| Q7Z3K3 | POGZ | S314 | ochoa | Pogo transposable element with ZNF domain (Suppressor of hairy wing homolog 5) (Zinc finger protein 280E) (Zinc finger protein 635) | Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms (PubMed:20562864). Promotes the repair of DNA double-strand breaks through the homologous recombination pathway (PubMed:26721387). {ECO:0000269|PubMed:20562864, ECO:0000269|PubMed:26721387}. |
| Q7Z4V5 | HDGFL2 | S146 | ochoa | Hepatoma-derived growth factor-related protein 2 (HDGF-related protein 2) (HRP-2) (Hepatoma-derived growth factor 2) (HDGF-2) | Acts as an epigenetic regulator of myogenesis in cooperation with DPF3a (isoform 2 of DPF3/BAF45C) (PubMed:32459350). Associates with the BAF complex via its interaction with DPF3a and HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters (PubMed:32459350). Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs (PubMed:26721387). Preferentially binds to chromatin regions marked by H3K9me3, H3K27me3 and H3K36me2 (PubMed:26721387, PubMed:32459350). Involved in cellular growth control, through the regulation of cyclin D1 expression (PubMed:25689719). {ECO:0000269|PubMed:25689719, ECO:0000269|PubMed:26721387, ECO:0000269|PubMed:32459350}. |
| Q7Z6E9 | RBBP6 | S945 | ochoa | E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis) | E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). {ECO:0000250|UniProtKB:P97868, ECO:0000269|PubMed:18851979, ECO:0000269|PubMed:24726359}.; FUNCTION: (Microbial infection) [Isoform 1]: Restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription. {ECO:0000269|PubMed:30550789}. |
| Q86UU1 | PHLDB1 | S430 | ochoa | Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha) | None |
| Q86VY4 | TSPYL5 | S180 | ochoa | Testis-specific Y-encoded-like protein 5 (TSPY-like protein 5) | Involved in modulation of cell growth and cellular response to gamma radiation probably via regulation of the Akt signaling pathway. Involved in regulation of p53/TP53. Suppresses p53/TP53 protein levels and promotes its ubiquitination; the function is dependent on USP7 and independent on MDM2. Proposed to displace p53/TP53 from interaction with USP7. {ECO:0000269|PubMed:20079711, ECO:0000269|PubMed:21170034}. |
| Q86X29 | LSR | S436 | ochoa | Lipolysis-stimulated lipoprotein receptor (Angulin-1) | Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity). Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (By similarity). {ECO:0000250|UniProtKB:Q99KG5, ECO:0000250|UniProtKB:Q9WU74}. |
| Q8IVF5 | TIAM2 | S1545 | ochoa | Rho guanine nucleotide exchange factor TIAM2 (SIF and TIAM1-like exchange factor) (T-lymphoma invasion and metastasis-inducing protein 2) (TIAM-2) | Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane (By similarity). Activates specifically RAC1, but not CDC42 and RHOA. {ECO:0000250, ECO:0000269|PubMed:10512681}. |
| Q8IX07 | ZFPM1 | S668 | ochoa | Zinc finger protein ZFPM1 (Friend of GATA protein 1) (FOG-1) (Friend of GATA 1) (Zinc finger protein 89A) (Zinc finger protein multitype 1) | Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity). {ECO:0000250}. |
| Q8IXQ3 | C9orf40 | S80 | ochoa | Uncharacterized protein C9orf40 | None |
| Q8N370 | SLC43A2 | S278 | psp | Large neutral amino acids transporter small subunit 4 (L-type amino acid transporter 4) (Solute carrier family 43 member 2) | Uniporter that mediates the transport of the stereospecific L-phenylalanine, L-methionine and L-branched-chain amino acids, between the extracellular space and the cytoplasm and may control the transepithelial (re)absorption of neutral amino acid in kidney and small intestine (PubMed:15659399, PubMed:30379325). The transport activity is mediated through facilitated diffusion and is sodium ions-, chloride ions- and pH-independent (PubMed:15659399). {ECO:0000269|PubMed:15659399, ECO:0000269|PubMed:30379325}. |
| Q8N4C8 | MINK1 | S903 | ochoa | Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6) | Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking (PubMed:10708748, PubMed:16337592). Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons (By similarity). Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates TANC1 upon stimulation by RAP2A, MBP and SMAD1 (PubMed:18930710, PubMed:21690388). Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1 (By similarity). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000250|UniProtKB:F1LP90, ECO:0000250|UniProtKB:Q9JM52, ECO:0000269|PubMed:10708748, ECO:0000269|PubMed:16337592, ECO:0000269|PubMed:18930710, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}.; FUNCTION: Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration. |
| Q8N6H7 | ARFGAP2 | S368 | ochoa | ADP-ribosylation factor GTPase-activating protein 2 (ARF GAP 2) (GTPase-activating protein ZNF289) (Zinc finger protein 289) | GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. {ECO:0000269|PubMed:17760859}. |
| Q8NEL9 | DDHD1 | S752 | ochoa | Phospholipase DDHD1 (EC 3.1.1.111) (EC 3.1.1.32) (DDHD domain-containing protein 1) (Phosphatidic acid-preferring phospholipase A1 homolog) (PA-PLA1) (EC 3.1.1.118) (Phospholipid sn-1 acylhydrolase) | Phospholipase A1 (PLA1) that hydrolyzes ester bonds at the sn-1 position of glycerophospholipids producing a free fatty acid and a lysophospholipid (Probable) (PubMed:20359546, PubMed:22922100). Prefers phosphatidate (1,2-diacyl-sn-glycero-3-phosphate, PA) as substrate in vitro, but can efficiently hydrolyze phosphatidylinositol (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol), PI), as well as a range of other glycerophospholipid substrates such as phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE), phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) and phosphatidylglycerol (1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol), PG) (Probable) (PubMed:20359546). Involved in the regulation of the endogenous content of polyunsaturated PI and PS lipids in the nervous system. Changes in these lipids extend to downstream metabolic products like PI phosphates PIP and PIP2, which play fundamental roles in cell biology (By similarity). Regulates mitochondrial morphology (PubMed:24599962). These dynamic changes may be due to PA hydrolysis at the mitochondrial surface (PubMed:24599962). May play a regulatory role in spermatogenesis or sperm function (PubMed:24599962). {ECO:0000250|UniProtKB:Q80YA3, ECO:0000269|PubMed:20359546, ECO:0000269|PubMed:22922100, ECO:0000269|PubMed:24599962, ECO:0000303|PubMed:24599962, ECO:0000305|PubMed:37189713}. |
| Q92997 | DVL3 | S605 | psp | Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) | Involved in the signal transduction pathway mediated by multiple Wnt genes. {ECO:0000250|UniProtKB:Q61062}. |
| Q96BD0 | SLCO4A1 | S356 | ochoa | Solute carrier organic anion transporter family member 4A1 (OATP4A1) (Colon organic anion transporter) (Organic anion transporter polypeptide-related protein 1) (OATP-RP1) (OATPRP1) (POAT) (Organic anion-transporting polypeptide E) (OATP-E) (Sodium-independent organic anion transporter E) (Solute carrier family 21 member 12) | Organic anion antiporter with apparent broad substrate specificity. Recognizes various substrates including thyroid hormones 3,3',5-triiodo-L-thyronine (T3), L-thyroxine (T4) and 3,3',5'-triiodo-L-thyronine (rT3), conjugated steroids such as estrone 3-sulfate and estradiol 17-beta glucuronide, bile acids such as taurocholate and prostanoids such as prostaglandin E2, likely operating in a tissue-specific manner (PubMed:10873595, PubMed:19129463, PubMed:30343886). May be involved in uptake of metabolites from the circulation into organs such as kidney, liver or placenta. Possibly drives the selective transport of thyroid hormones and estrogens coupled to an outward glutamate gradient across the microvillous membrane of the placenta (PubMed:30343886). The transport mechanism, its electrogenicity and potential tissue-specific counterions remain to be elucidated (Probable). {ECO:0000269|PubMed:10873595, ECO:0000269|PubMed:19129463, ECO:0000269|PubMed:30343886, ECO:0000305}. |
| Q96C92 | ENTR1 | S258 | ochoa | Endosome-associated-trafficking regulator 1 (Antigen NY-CO-3) (Serologically defined colon cancer antigen 3) | Endosome-associated protein that plays a role in membrane receptor sorting, cytokinesis and ciliogenesis (PubMed:23108400, PubMed:25278552, PubMed:27767179). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1 (PubMed:25278552). Involved in the regulation of cytokinesis; the function may involve PTPN13 and GIT1 (PubMed:23108400). Plays a role in the formation of cilia (PubMed:27767179). Involved in cargo protein localization, such as PKD2, at primary cilia (PubMed:27767179). Involved in the presentation of the tumor necrosis factor (TNF) receptor TNFRSF1A on the cell surface, and hence in the modulation of the TNF-induced apoptosis (By similarity). {ECO:0000250|UniProtKB:A2AIW0, ECO:0000269|PubMed:23108400, ECO:0000269|PubMed:25278552, ECO:0000269|PubMed:27767179}. |
| Q96EV2 | RBM33 | S997 | ochoa | RNA-binding protein 33 (Proline-rich protein 8) (RNA-binding motif protein 33) | RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as mRNA export, mRNA stability and/or translation (PubMed:35589130, PubMed:37257451). Binds a subset of intronless RNAs containing GC-rich elements, such as NORAD, and promotes their nuclear export by recruiting target RNAs to components of the NXF1-NXT1 RNA export machinery (PubMed:35589130). Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, promoting their demethylation by ALKBH5 (PubMed:37257451). Acts as an molecular adapter, which (1) promotes ALKBH5 recruitment to m6A-containing transcripts and (2) activates ALKBH5 demethylase activity by recruiting SENP1, leading to ALKBH5 deSUMOylation and subsequent activation (PubMed:37257451). {ECO:0000269|PubMed:35589130, ECO:0000269|PubMed:37257451}. |
| Q96HH9 | GRAMD2B | S296 | ochoa | GRAM domain-containing protein 2B (HCV NS3-transactivated protein 2) | None |
| Q96NE9 | FRMD6 | S415 | ochoa | FERM domain-containing protein 6 (Willin) | None |
| Q96RU3 | FNBP1 | S303 | ochoa | Formin-binding protein 1 (Formin-binding protein 17) (hFBP17) | May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL. {ECO:0000250, ECO:0000269|PubMed:15252009, ECO:0000269|PubMed:16318909, ECO:0000269|PubMed:16326391, ECO:0000269|PubMed:16418535, ECO:0000269|PubMed:17512409}. |
| Q9BQG0 | MYBBP1A | S1207 | ochoa | Myb-binding protein 1A | May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (By similarity). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (By similarity). Has a role in rRNA biogenesis together with PWP1 (PubMed:29065309). {ECO:0000250|UniProtKB:Q7TPV4, ECO:0000269|PubMed:29065309}. |
| Q9BU76 | MMTAG2 | S127 | ochoa | Multiple myeloma tumor-associated protein 2 (hMMTAG2) | None |
| Q9BZI7 | UPF3B | S34 | ochoa | Regulator of nonsense transcripts 3B (Nonsense mRNA reducing factor 3B) (Up-frameshift suppressor 3 homolog B) (hUpf3B) (Up-frameshift suppressor 3 homolog on chromosome X) (hUpf3p-X) | Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA upstream of exon-exon junctions. In vitro, stimulates translation; the function is independent of association with UPF2 and components of the EJC core. {ECO:0000269|PubMed:11163187, ECO:0000269|PubMed:12718880, ECO:0000269|PubMed:16209946, ECO:0000269|PubMed:16601204, ECO:0000269|PubMed:18066079}. |
| Q9H6S3 | EPS8L2 | S21 | ochoa | Epidermal growth factor receptor kinase substrate 8-like protein 2 (EPS8-like protein 2) (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-related protein 2) | Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity). {ECO:0000250|UniProtKB:Q99K30, ECO:0000269|PubMed:14565974}. |
| Q9H9Q4 | NHEJ1 | S251 | psp | Non-homologous end-joining factor 1 (Protein cernunnos) (XRCC4-like factor) | DNA repair protein involved in DNA non-homologous end joining (NHEJ); it is required for double-strand break (DSB) repair and V(D)J recombination and is also involved in telomere maintenance (PubMed:16439204, PubMed:16439205, PubMed:17317666, PubMed:17470781, PubMed:17717001, PubMed:18158905, PubMed:18644470, PubMed:20558749, PubMed:26100018, PubMed:28369633). Plays a key role in NHEJ by promoting the ligation of various mismatched and non-cohesive ends (PubMed:17470781, PubMed:17717001, PubMed:19056826). Together with PAXX, collaborates with DNA polymerase lambda (POLL) to promote joining of non-cohesive DNA ends (PubMed:25670504, PubMed:30250067). May act in concert with XRCC5-XRCC6 (Ku) to stimulate XRCC4-mediated joining of blunt ends and several types of mismatched ends that are non-complementary or partially complementary (PubMed:16439204, PubMed:16439205, PubMed:17317666, PubMed:17470781). In some studies, has been shown to associate with XRCC4 to form alternating helical filaments that bridge DNA and act like a bandage, holding together the broken DNA until it is repaired (PubMed:21768349, PubMed:21775435, PubMed:22228831, PubMed:22287571, PubMed:26100018, PubMed:27437582, PubMed:28500754). Alternatively, it has also been shown that rather than forming filaments, a single NHEJ1 dimer interacts through both head domains with XRCC4 to promote the close alignment of DNA ends (By similarity). The XRCC4-NHEJ1/XLF subcomplex binds to the DNA fragments of a DSB in a highly diffusive manner and robustly bridges two independent DNA molecules, holding the broken DNA fragments in close proximity to one other (PubMed:27437582, PubMed:28500754). The mobility of the bridges ensures that the ends remain accessible for further processing by other repair factors (PubMed:27437582). Binds DNA in a length-dependent manner (PubMed:17317666, PubMed:18158905). {ECO:0000250|UniProtKB:A0A1L8ENT6, ECO:0000269|PubMed:16439204, ECO:0000269|PubMed:16439205, ECO:0000269|PubMed:17317666, ECO:0000269|PubMed:17470781, ECO:0000269|PubMed:17717001, ECO:0000269|PubMed:18158905, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:19056826, ECO:0000269|PubMed:20558749, ECO:0000269|PubMed:21768349, ECO:0000269|PubMed:21775435, ECO:0000269|PubMed:22228831, ECO:0000269|PubMed:22287571, ECO:0000269|PubMed:25670504, ECO:0000269|PubMed:26100018, ECO:0000269|PubMed:27437582, ECO:0000269|PubMed:28369633, ECO:0000269|PubMed:28500754, ECO:0000269|PubMed:30250067}. |
| Q9HBR0 | SLC38A10 | S806 | ochoa | Solute carrier family 38 member 10 (Amino acid transporter SLC38A10) | Facilitates bidirectional transport of amino acids. May act as a glutamate sensor that regulates glutamate-glutamine cycle and mTOR signaling in the brain. The transport mechanism remains to be elucidated. {ECO:0000250|UniProtKB:Q5I012}. |
| Q9HC52 | CBX8 | S315 | ochoa | Chromobox protein homolog 8 (Polycomb 3 homolog) (Pc3) (hPc3) (Rectachrome 1) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269|PubMed:21282530}. |
| Q9HCI7 | MSL2 | S347 | ochoa | E3 ubiquitin-protein ligase MSL2 (EC 2.3.2.27) (Male-specific lethal 2-like 1) (MSL2-like 1) (Male-specific lethal-2 homolog) (MSL-2) (Male-specific lethal-2 homolog 1) (RING finger protein 184) | Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:16543150, PubMed:33837287). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). MSL2 plays a key role in gene dosage by ensuring biallelic expression of a subset of dosage-sensitive genes, including many haploinsufficient genes (By similarity). Acts by promoting promoter-enhancer contacts, thereby preventing DNA methylation of one allele and creating a methylation-free environment for methylation-sensitive transcription factors such as SP1, KANSL1 and KANSL3 (By similarity). Also acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A (PubMed:21726816, PubMed:30930284). This activity is greatly enhanced by heterodimerization with MSL1 (PubMed:21726816, PubMed:30930284). H2B ubiquitination in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (PubMed:21726816). Also involved in the DNA damage response by mediating ubiquitination of TP53/p53 and TP53BP1 (PubMed:19033443, PubMed:23874665). {ECO:0000250|UniProtKB:Q69ZF8, ECO:0000250|UniProtKB:Q9D1P2, ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:19033443, ECO:0000269|PubMed:21726816, ECO:0000269|PubMed:23874665, ECO:0000269|PubMed:30930284, ECO:0000269|PubMed:33837287}. |
| Q9NRW1 | RAB6B | S23 | ochoa | Ras-related protein Rab-6B (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology (By similarity). Recruits VPS13B to the Golgi membrane (PubMed:25492866). Regulates the compacted morphology of the Golgi (PubMed:26209634). Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells (PubMed:17707369). Plays a role in neuron projection development (PubMed:25492866). {ECO:0000250|UniProtKB:P20340, ECO:0000269|PubMed:17707369, ECO:0000269|PubMed:25492866, ECO:0000269|PubMed:26209634}. |
| Q9NWH9 | SLTM | S800 | ochoa | SAFB-like transcription modulator (Modulator of estrogen-induced transcription) | When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis. {ECO:0000250}. |
| Q9UGU0 | TCF20 | S884 | ochoa | Transcription factor 20 (TCF-20) (Nuclear factor SPBP) (Protein AR1) (Stromelysin-1 PDGF-responsive element-binding protein) (SPRE-binding protein) | Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator. {ECO:0000269|PubMed:10995766}. |
| Q9UKI2 | CDC42EP3 | S93 | ochoa | Cdc42 effector protein 3 (Binder of Rho GTPases 2) (MSE55-related Cdc42-binding protein) | Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. {ECO:0000269|PubMed:10490598, ECO:0000269|PubMed:11035016}. |
| Q9UNZ2 | NSFL1C | S62 | ochoa | NSFL1 cofactor p47 (UBX domain-containing protein 2C) (p97 cofactor p47) | Reduces the ATPase activity of VCP (By similarity). Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro) (PubMed:15498563). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807). Also, regulates spindle orientation during mitosis (PubMed:23649807). {ECO:0000250|UniProtKB:O35987, ECO:0000269|PubMed:15498563, ECO:0000269|PubMed:23649807}. |
| Q9Y4G8 | RAPGEF2 | S1253 | ochoa | Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1) | Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Also acts as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP (PubMed:23800469, PubMed:10801446) or not (PubMed:10548487, PubMed:10608844, PubMed:11359771). Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Also provides inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions. {ECO:0000269|PubMed:10548487, ECO:0000269|PubMed:10608844, ECO:0000269|PubMed:10608883, ECO:0000269|PubMed:10801446, ECO:0000269|PubMed:10934204, ECO:0000269|PubMed:11359771, ECO:0000269|PubMed:12391161, ECO:0000269|PubMed:16272156, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:23800469}. |
| P62241 | RPS8 | S66 | Sugiyama | Small ribosomal subunit protein eS8 (40S ribosomal protein S8) | Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| Q9Y696 | CLIC4 | S31 | Sugiyama | Chloride intracellular channel protein 4 (Glutaredoxin-like oxidoreductase CLIC4) (EC 1.8.-.-) (Intracellular chloride ion channel protein p64H1) | In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor (PubMed:25581026, PubMed:37759794). Can insert into membranes and form voltage-dependent multi-ion conductive channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions (By similarity) (PubMed:16176272). Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). Promotes cell-surface expression of HRH3. {ECO:0000250|UniProtKB:Q9Z0W7, ECO:0000269|PubMed:12163372, ECO:0000269|PubMed:14569596, ECO:0000269|PubMed:16176272, ECO:0000269|PubMed:16239224, ECO:0000269|PubMed:18302930, ECO:0000269|PubMed:19247789, ECO:0000269|PubMed:25581026, ECO:0000269|PubMed:37759794}. |
| P13639 | EEF2 | S793 | Sugiyama | Elongation factor 2 (EF-2) (EC 3.6.5.-) | Catalyzes the GTP-dependent ribosomal translocation step during translation elongation (PubMed:26593721). During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively (PubMed:26593721). Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (PubMed:26593721). {ECO:0000269|PubMed:26593721}. |
| Q8NBP7 | PCSK9 | S668 | GPS6 | Proprotein convertase subtilisin/kexin type 9 (EC 3.4.21.-) (Neural apoptosis-regulated convertase 1) (NARC-1) (Proprotein convertase 9) (PC9) (Subtilisin/kexin-like protease PC9) | Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments (PubMed:18039658). Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation (PubMed:17461796, PubMed:18197702, PubMed:18799458, PubMed:22074827). Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner. Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway (PubMed:18660751). Inhibits epithelial Na(+) channel (ENaC)-mediated Na(+) absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation. Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways. {ECO:0000269|PubMed:17461796, ECO:0000269|PubMed:18039658, ECO:0000269|PubMed:18197702, ECO:0000269|PubMed:18660751, ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22074827, ECO:0000269|PubMed:22493497, ECO:0000269|PubMed:22580899}. |
| O43242 | PSMD3 | S450 | Sugiyama | 26S proteasome non-ATPase regulatory subunit 3 (26S proteasome regulatory subunit RPN3) (26S proteasome regulatory subunit S3) (Proteasome subunit p58) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. {ECO:0000269|PubMed:1317798}. |
| Q9H093 | NUAK2 | S327 | Sugiyama | NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (Omphalocele kinase 2) (SNF1/AMP kinase-related kinase) (SNARK) | Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Phosphorylates LATS1 and LATS2. Plays a key role in neural tube closure during embryonic development through LATS2 phosphorylation and regulation of the nuclear localization of YAP1 a critical downstream regulatory target in the Hippo signaling pathway (PubMed:32845958). {ECO:0000269|PubMed:14575707, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15345718, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:32845958}. |
| P53634 | CTSC | S428 | Sugiyama | Dipeptidyl peptidase 1 (EC 3.4.14.1) (Cathepsin C) (Cathepsin J) (Dipeptidyl peptidase I) (DPP-I) (DPPI) (Dipeptidyl transferase) [Cleaved into: Dipeptidyl peptidase 1 exclusion domain chain (Dipeptidyl peptidase I exclusion domain chain); Dipeptidyl peptidase 1 heavy chain (Dipeptidyl peptidase I heavy chain); Dipeptidyl peptidase 1 light chain (Dipeptidyl peptidase I light chain)] | Thiol protease (PubMed:1586157). Has dipeptidylpeptidase activity (PubMed:1586157). Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids (PubMed:1586157). Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate (PubMed:1586157). Can act as both an exopeptidase and endopeptidase (PubMed:1586157). Activates serine proteases such as elastase, cathepsin G and granzymes A and B (PubMed:8428921). {ECO:0000269|PubMed:1586157, ECO:0000269|PubMed:8428921}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.000016 | 4.804 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.000019 | 4.711 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.000042 | 4.374 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.000088 | 4.057 |
| R-HSA-5578775 | Ion homeostasis | 0.001378 | 2.861 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.002109 | 2.676 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.005044 | 2.297 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.008127 | 2.090 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.005954 | 2.225 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.005786 | 2.238 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 0.007209 | 2.142 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.005218 | 2.282 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.003680 | 2.434 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 0.004960 | 2.304 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.007803 | 2.108 |
| R-HSA-75153 | Apoptotic execution phase | 0.007732 | 2.112 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.008469 | 2.072 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.010170 | 1.993 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.010740 | 1.969 |
| R-HSA-8939211 | ESR-mediated signaling | 0.012435 | 1.905 |
| R-HSA-211728 | Regulation of PAK-2p34 activity by PS-GAP/RHG10 | 0.014672 | 1.834 |
| R-HSA-5657560 | Hereditary fructose intolerance | 0.014672 | 1.834 |
| R-HSA-373756 | SDK interactions | 0.014672 | 1.834 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.016063 | 1.794 |
| R-HSA-5609974 | Defective PGM1 causes PGM1-CDG | 0.021928 | 1.659 |
| R-HSA-211736 | Stimulation of the cell death response by PAK-2p34 | 0.029131 | 1.536 |
| R-HSA-3656535 | TGFBR1 LBD Mutants in Cancer | 0.029131 | 1.536 |
| R-HSA-3645790 | TGFBR2 Kinase Domain Mutants in Cancer | 0.029131 | 1.536 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 0.036281 | 1.440 |
| R-HSA-8952158 | RUNX3 regulates BCL2L11 (BIM) transcription | 0.043379 | 1.363 |
| R-HSA-3656532 | TGFBR1 KD Mutants in Cancer | 0.043379 | 1.363 |
| R-HSA-3656534 | Loss of Function of TGFBR1 in Cancer | 0.050425 | 1.297 |
| R-HSA-3304356 | SMAD2/3 Phosphorylation Motif Mutants in Cancer | 0.050425 | 1.297 |
| R-HSA-6802953 | RAS signaling downstream of NF1 loss-of-function variants | 0.064363 | 1.191 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 0.071256 | 1.147 |
| R-HSA-446107 | Type I hemidesmosome assembly | 0.078099 | 1.107 |
| R-HSA-201688 | WNT mediated activation of DVL | 0.084891 | 1.071 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 0.091634 | 1.038 |
| R-HSA-5358493 | Synthesis of diphthamide-EEF2 | 0.104972 | 0.979 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 0.111568 | 0.952 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.031044 | 1.508 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 0.131069 | 0.883 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.069096 | 1.161 |
| R-HSA-72187 | mRNA 3'-end processing | 0.073255 | 1.135 |
| R-HSA-5334118 | DNA methylation | 0.228122 | 0.642 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.228122 | 0.642 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 0.272537 | 0.565 |
| R-HSA-156902 | Peptide chain elongation | 0.161372 | 0.792 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.329497 | 0.482 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.192947 | 0.715 |
| R-HSA-1989781 | PPARA activates gene expression | 0.137063 | 0.863 |
| R-HSA-72172 | mRNA Splicing | 0.230398 | 0.638 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.156411 | 0.806 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 0.298999 | 0.524 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.140442 | 0.853 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.209224 | 0.679 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.233385 | 0.632 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 0.181020 | 0.742 |
| R-HSA-169911 | Regulation of Apoptosis | 0.039065 | 1.408 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.143833 | 0.842 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.329497 | 0.482 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.233385 | 0.632 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 0.111568 | 0.952 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 0.049599 | 1.305 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.021215 | 1.673 |
| R-HSA-6798695 | Neutrophil degranulation | 0.025955 | 1.586 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.181061 | 0.742 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 0.137474 | 0.862 |
| R-HSA-9664420 | Killing mechanisms | 0.137474 | 0.862 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 0.222385 | 0.653 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.261677 | 0.582 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.109103 | 0.962 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 0.057420 | 1.241 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 0.098328 | 1.007 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 0.277907 | 0.556 |
| R-HSA-3304351 | Signaling by TGF-beta Receptor Complex in Cancer | 0.064363 | 1.191 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.025168 | 1.599 |
| R-HSA-4641258 | Degradation of DVL | 0.042471 | 1.372 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.174416 | 0.758 |
| R-HSA-3642278 | Loss of Function of TGFBR2 in Cancer | 0.029131 | 1.536 |
| R-HSA-3304349 | Loss of Function of SMAD2/3 in Cancer | 0.057420 | 1.241 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.104972 | 0.979 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.131069 | 0.883 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 0.216605 | 0.664 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.092899 | 1.032 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.293784 | 0.532 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.293784 | 0.532 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.329497 | 0.482 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.156411 | 0.806 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.304176 | 0.517 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.317824 | 0.498 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.079640 | 1.099 |
| R-HSA-9927020 | Heme assimilation | 0.143833 | 0.842 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.199008 | 0.701 |
| R-HSA-8873719 | RAB geranylgeranylation | 0.090646 | 1.043 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.187060 | 0.728 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.045525 | 1.342 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.314416 | 0.502 |
| R-HSA-8964046 | VLDL clearance | 0.071256 | 1.147 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 0.199008 | 0.701 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 0.245084 | 0.611 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 0.261677 | 0.582 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.267127 | 0.573 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.267127 | 0.573 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.304176 | 0.517 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.304176 | 0.517 |
| R-HSA-9710421 | Defective pyroptosis | 0.314416 | 0.502 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.329497 | 0.482 |
| R-HSA-8964038 | LDL clearance | 0.018555 | 1.732 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 0.081806 | 1.087 |
| R-HSA-4086400 | PCP/CE pathway | 0.133405 | 0.875 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 0.045983 | 1.337 |
| R-HSA-3928664 | Ephrin signaling | 0.156411 | 0.806 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.199008 | 0.701 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.199008 | 0.701 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.030445 | 1.516 |
| R-HSA-5689603 | UCH proteinases | 0.128449 | 0.891 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.148522 | 0.828 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.298999 | 0.524 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.063550 | 1.197 |
| R-HSA-198693 | AKT phosphorylates targets in the nucleus | 0.084891 | 1.071 |
| R-HSA-428540 | Activation of RAC1 | 0.104972 | 0.979 |
| R-HSA-1237044 | Erythrocytes take up carbon dioxide and release oxygen | 0.162631 | 0.789 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.216605 | 0.664 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.037988 | 1.420 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.272537 | 0.565 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 0.272537 | 0.565 |
| R-HSA-4641257 | Degradation of AXIN | 0.277907 | 0.556 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.277907 | 0.556 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 0.111568 | 0.952 |
| R-HSA-1480926 | O2/CO2 exchange in erythrocytes | 0.162631 | 0.789 |
| R-HSA-983189 | Kinesins | 0.090646 | 1.043 |
| R-HSA-164944 | Nef and signal transduction | 0.064363 | 1.191 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 0.071256 | 1.147 |
| R-HSA-70350 | Fructose catabolism | 0.137474 | 0.862 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.090646 | 1.043 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.095168 | 1.022 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.250656 | 0.601 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 0.256186 | 0.591 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.261677 | 0.582 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 0.261677 | 0.582 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.304176 | 0.517 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.304176 | 0.517 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.043529 | 1.361 |
| R-HSA-199991 | Membrane Trafficking | 0.060416 | 1.219 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 0.216605 | 0.664 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.110118 | 0.958 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.161372 | 0.792 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 0.250656 | 0.601 |
| R-HSA-1247673 | Erythrocytes take up oxygen and release carbon dioxide | 0.111568 | 0.952 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 0.118116 | 0.928 |
| R-HSA-70370 | Galactose catabolism | 0.143833 | 0.842 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.193056 | 0.714 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.090646 | 1.043 |
| R-HSA-5694530 | Cargo concentration in the ER | 0.239472 | 0.621 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.293784 | 0.532 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.298999 | 0.524 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.298999 | 0.524 |
| R-HSA-195721 | Signaling by WNT | 0.209541 | 0.679 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.239472 | 0.621 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.268827 | 0.571 |
| R-HSA-9907900 | Proteasome assembly | 0.319480 | 0.496 |
| R-HSA-5652084 | Fructose metabolism | 0.187060 | 0.728 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.081806 | 1.087 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.288531 | 0.540 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 0.288531 | 0.540 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.314416 | 0.502 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.319480 | 0.496 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.324507 | 0.489 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.312405 | 0.505 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.177046 | 0.752 |
| R-HSA-9839389 | TGFBR3 regulates TGF-beta signaling | 0.071256 | 1.147 |
| R-HSA-6811555 | PI5P Regulates TP53 Acetylation | 0.118116 | 0.928 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 0.162631 | 0.789 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.113863 | 0.944 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.324507 | 0.489 |
| R-HSA-69275 | G2/M Transition | 0.194121 | 0.712 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.055570 | 1.255 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.197870 | 0.704 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.334133 | 0.476 |
| R-HSA-9707616 | Heme signaling | 0.095168 | 1.022 |
| R-HSA-3214842 | HDMs demethylate histones | 0.204917 | 0.688 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.174416 | 0.758 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.020539 | 1.687 |
| R-HSA-8876725 | Protein methylation | 0.131069 | 0.883 |
| R-HSA-5635838 | Activation of SMO | 0.137474 | 0.862 |
| R-HSA-879518 | Organic anion transport by SLCO transporters | 0.193056 | 0.714 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.233818 | 0.631 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.293784 | 0.532 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.298999 | 0.524 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.324507 | 0.489 |
| R-HSA-9842663 | Signaling by LTK | 0.111568 | 0.952 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.131069 | 0.883 |
| R-HSA-200425 | Carnitine shuttle | 0.193056 | 0.714 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.025033 | 1.601 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.288531 | 0.540 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.304176 | 0.517 |
| R-HSA-2559583 | Cellular Senescence | 0.060846 | 1.216 |
| R-HSA-446728 | Cell junction organization | 0.023777 | 1.624 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.317824 | 0.498 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.027168 | 1.566 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.033034 | 1.481 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.225241 | 0.647 |
| R-HSA-9607240 | FLT3 Signaling | 0.298999 | 0.524 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.199008 | 0.701 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.324507 | 0.489 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.324507 | 0.489 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.170224 | 0.769 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.170224 | 0.769 |
| R-HSA-1500931 | Cell-Cell communication | 0.039160 | 1.407 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.073772 | 1.132 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.236104 | 0.627 |
| R-HSA-1181150 | Signaling by NODAL | 0.168806 | 0.773 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.116263 | 0.935 |
| R-HSA-2262752 | Cellular responses to stress | 0.021486 | 1.668 |
| R-HSA-9909396 | Circadian clock | 0.298823 | 0.525 |
| R-HSA-8854214 | TBC/RABGAPs | 0.055208 | 1.258 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.250656 | 0.601 |
| R-HSA-6807070 | PTEN Regulation | 0.109578 | 0.960 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.241547 | 0.617 |
| R-HSA-109581 | Apoptosis | 0.045193 | 1.345 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.049365 | 1.307 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.025604 | 1.592 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.133405 | 0.875 |
| R-HSA-69541 | Stabilization of p53 | 0.288531 | 0.540 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.213041 | 0.672 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.190283 | 0.721 |
| R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 0.204917 | 0.688 |
| R-HSA-5609975 | Diseases associated with glycosylation precursor biosynthesis | 0.250656 | 0.601 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 0.256186 | 0.591 |
| R-HSA-421270 | Cell-cell junction organization | 0.141819 | 0.848 |
| R-HSA-162582 | Signal Transduction | 0.123900 | 0.907 |
| R-HSA-5576891 | Cardiac conduction | 0.024112 | 1.618 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.121101 | 0.917 |
| R-HSA-202433 | Generation of second messenger molecules | 0.293784 | 0.532 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.204958 | 0.688 |
| R-HSA-418990 | Adherens junctions interactions | 0.257888 | 0.589 |
| R-HSA-397014 | Muscle contraction | 0.029472 | 1.531 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.193056 | 0.714 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.261677 | 0.582 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.271558 | 0.566 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.032589 | 1.487 |
| R-HSA-8982491 | Glycogen metabolism | 0.293784 | 0.532 |
| R-HSA-9824272 | Somitogenesis | 0.324507 | 0.489 |
| R-HSA-5357801 | Programmed Cell Death | 0.086323 | 1.064 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 0.193056 | 0.714 |
| R-HSA-422475 | Axon guidance | 0.241616 | 0.617 |
| R-HSA-3322077 | Glycogen synthesis | 0.168806 | 0.773 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.329497 | 0.482 |
| R-HSA-9675108 | Nervous system development | 0.287790 | 0.541 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.279611 | 0.553 |
| R-HSA-983712 | Ion channel transport | 0.069145 | 1.160 |
| R-HSA-382551 | Transport of small molecules | 0.206929 | 0.684 |
| R-HSA-202403 | TCR signaling | 0.227953 | 0.642 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.256186 | 0.591 |
| R-HSA-157118 | Signaling by NOTCH | 0.301875 | 0.520 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.250656 | 0.601 |
| R-HSA-163685 | Integration of energy metabolism | 0.312405 | 0.505 |
| R-HSA-109582 | Hemostasis | 0.075209 | 1.124 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.263367 | 0.579 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.156207 | 0.806 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.195616 | 0.709 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.171793 | 0.765 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.186401 | 0.730 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.320530 | 0.494 |
| R-HSA-9679506 | SARS-CoV Infections | 0.253875 | 0.595 |
| R-HSA-449147 | Signaling by Interleukins | 0.050620 | 1.296 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.334450 | 0.476 |
| R-HSA-437239 | Recycling pathway of L1 | 0.334450 | 0.476 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.339367 | 0.469 |
| R-HSA-70263 | Gluconeogenesis | 0.339367 | 0.469 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.339367 | 0.469 |
| R-HSA-9766229 | Degradation of CDH1 | 0.344248 | 0.463 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.344248 | 0.463 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.344248 | 0.463 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.344756 | 0.462 |
| R-HSA-69242 | S Phase | 0.347432 | 0.459 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.352773 | 0.453 |
| R-HSA-9864848 | Complex IV assembly | 0.353904 | 0.451 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.353904 | 0.451 |
| R-HSA-912446 | Meiotic recombination | 0.353904 | 0.451 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.353904 | 0.451 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.353904 | 0.451 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.355438 | 0.449 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.358678 | 0.445 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.358678 | 0.445 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.358678 | 0.445 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.358678 | 0.445 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.358678 | 0.445 |
| R-HSA-69306 | DNA Replication | 0.360757 | 0.443 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.363410 | 0.440 |
| R-HSA-73887 | Death Receptor Signaling | 0.363410 | 0.440 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.363418 | 0.440 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.363418 | 0.440 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.363418 | 0.440 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.363418 | 0.440 |
| R-HSA-72649 | Translation initiation complex formation | 0.368123 | 0.434 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.368123 | 0.434 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.368123 | 0.434 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.372793 | 0.429 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.372793 | 0.429 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.377429 | 0.423 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.377429 | 0.423 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.377429 | 0.423 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.382031 | 0.418 |
| R-HSA-1483166 | Synthesis of PA | 0.382031 | 0.418 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.386600 | 0.413 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.386600 | 0.413 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.386600 | 0.413 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.389709 | 0.409 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.391135 | 0.408 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 0.391135 | 0.408 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.395636 | 0.403 |
| R-HSA-351202 | Metabolism of polyamines | 0.395636 | 0.403 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.395636 | 0.403 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.400105 | 0.398 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.400105 | 0.398 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.400304 | 0.398 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.404541 | 0.393 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.404541 | 0.393 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.404541 | 0.393 |
| R-HSA-373755 | Semaphorin interactions | 0.408944 | 0.388 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.408944 | 0.388 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.410403 | 0.387 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.412967 | 0.384 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.414151 | 0.383 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.415524 | 0.381 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.417654 | 0.379 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.421962 | 0.375 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 0.426237 | 0.370 |
| R-HSA-72766 | Translation | 0.426291 | 0.370 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.430482 | 0.366 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.438074 | 0.358 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.438877 | 0.358 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.438877 | 0.358 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 0.438877 | 0.358 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.438877 | 0.358 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.438877 | 0.358 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.438877 | 0.358 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.443028 | 0.354 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.443028 | 0.354 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.443028 | 0.354 |
| R-HSA-9638482 | Metal ion assimilation from the host | 0.443028 | 0.354 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.447149 | 0.350 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.447149 | 0.350 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.447149 | 0.350 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.451240 | 0.346 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.451240 | 0.346 |
| R-HSA-5663084 | Diseases of carbohydrate metabolism | 0.451240 | 0.346 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.455301 | 0.342 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.459332 | 0.338 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.463023 | 0.334 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.463334 | 0.334 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.466533 | 0.331 |
| R-HSA-8957322 | Metabolism of steroids | 0.468436 | 0.329 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.471249 | 0.327 |
| R-HSA-5619084 | ABC transporter disorders | 0.471249 | 0.327 |
| R-HSA-9955298 | SLC-mediated transport of organic anions | 0.471249 | 0.327 |
| R-HSA-9659379 | Sensory processing of sound | 0.475163 | 0.323 |
| R-HSA-9824446 | Viral Infection Pathways | 0.477090 | 0.321 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.479048 | 0.320 |
| R-HSA-9833482 | PKR-mediated signaling | 0.479048 | 0.320 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.482348 | 0.317 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.482905 | 0.316 |
| R-HSA-977225 | Amyloid fiber formation | 0.482905 | 0.316 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.486733 | 0.313 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.486733 | 0.313 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.487114 | 0.312 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.489486 | 0.310 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.490533 | 0.309 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.494306 | 0.306 |
| R-HSA-1500620 | Meiosis | 0.498050 | 0.303 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.498050 | 0.303 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.501768 | 0.299 |
| R-HSA-168256 | Immune System | 0.502937 | 0.298 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 0.505457 | 0.296 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.505457 | 0.296 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.509120 | 0.293 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.516365 | 0.287 |
| R-HSA-202424 | Downstream TCR signaling | 0.519948 | 0.284 |
| R-HSA-68882 | Mitotic Anaphase | 0.521976 | 0.282 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.523504 | 0.281 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.523504 | 0.281 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.524244 | 0.280 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.527035 | 0.278 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.530539 | 0.275 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.537471 | 0.270 |
| R-HSA-1474290 | Collagen formation | 0.537471 | 0.270 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.540898 | 0.267 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.540898 | 0.267 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.544301 | 0.264 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.544301 | 0.264 |
| R-HSA-2168880 | Scavenging of heme from plasma | 0.544301 | 0.264 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.544301 | 0.264 |
| R-HSA-168249 | Innate Immune System | 0.544506 | 0.264 |
| R-HSA-162906 | HIV Infection | 0.546529 | 0.262 |
| R-HSA-5389840 | Mitochondrial translation elongation | 0.547678 | 0.261 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.547678 | 0.261 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.547678 | 0.261 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.547678 | 0.261 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.551031 | 0.259 |
| R-HSA-157579 | Telomere Maintenance | 0.551031 | 0.259 |
| R-HSA-5368286 | Mitochondrial translation initiation | 0.554359 | 0.256 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.557662 | 0.254 |
| R-HSA-3214847 | HATs acetylate histones | 0.557662 | 0.254 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.560941 | 0.251 |
| R-HSA-70171 | Glycolysis | 0.560941 | 0.251 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.560941 | 0.251 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.561694 | 0.250 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.562087 | 0.250 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.564196 | 0.249 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.564196 | 0.249 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.564196 | 0.249 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.567428 | 0.246 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.567428 | 0.246 |
| R-HSA-192823 | Viral mRNA Translation | 0.570635 | 0.244 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 0.570635 | 0.244 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.573819 | 0.241 |
| R-HSA-68886 | M Phase | 0.574694 | 0.241 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.576979 | 0.239 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.576979 | 0.239 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.583231 | 0.234 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.586322 | 0.232 |
| R-HSA-69239 | Synthesis of DNA | 0.586322 | 0.232 |
| R-HSA-211000 | Gene Silencing by RNA | 0.586322 | 0.232 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.589390 | 0.230 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.589390 | 0.230 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.589390 | 0.230 |
| R-HSA-5419276 | Mitochondrial translation termination | 0.592436 | 0.227 |
| R-HSA-4839726 | Chromatin organization | 0.592972 | 0.227 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.601440 | 0.221 |
| R-HSA-5688426 | Deubiquitination | 0.605015 | 0.218 |
| R-HSA-8953854 | Metabolism of RNA | 0.610621 | 0.214 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.613139 | 0.212 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.616010 | 0.210 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.618860 | 0.208 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.618860 | 0.208 |
| R-HSA-373760 | L1CAM interactions | 0.618860 | 0.208 |
| R-HSA-5663205 | Infectious disease | 0.620567 | 0.207 |
| R-HSA-70326 | Glucose metabolism | 0.621689 | 0.206 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.621689 | 0.206 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.624498 | 0.204 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.627285 | 0.203 |
| R-HSA-1640170 | Cell Cycle | 0.629818 | 0.201 |
| R-HSA-68875 | Mitotic Prophase | 0.630052 | 0.201 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.632799 | 0.199 |
| R-HSA-73886 | Chromosome Maintenance | 0.632799 | 0.199 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.638232 | 0.195 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.646232 | 0.190 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.646232 | 0.190 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.646232 | 0.190 |
| R-HSA-194138 | Signaling by VEGF | 0.646232 | 0.190 |
| R-HSA-69206 | G1/S Transition | 0.646232 | 0.190 |
| R-HSA-114608 | Platelet degranulation | 0.651468 | 0.186 |
| R-HSA-69481 | G2/M Checkpoints | 0.651468 | 0.186 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.655896 | 0.183 |
| R-HSA-1474165 | Reproduction | 0.661710 | 0.179 |
| R-HSA-9843745 | Adipogenesis | 0.664223 | 0.178 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.669195 | 0.174 |
| R-HSA-5368287 | Mitochondrial translation | 0.683676 | 0.165 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.697528 | 0.156 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.699777 | 0.155 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.704227 | 0.152 |
| R-HSA-597592 | Post-translational protein modification | 0.707758 | 0.150 |
| R-HSA-9758941 | Gastrulation | 0.710778 | 0.148 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.717186 | 0.144 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.719291 | 0.143 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.721379 | 0.142 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.723453 | 0.141 |
| R-HSA-9612973 | Autophagy | 0.725511 | 0.139 |
| R-HSA-9610379 | HCMV Late Events | 0.727554 | 0.138 |
| R-HSA-9711097 | Cellular response to starvation | 0.729582 | 0.137 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.729582 | 0.137 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.733593 | 0.135 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.733593 | 0.135 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.741439 | 0.130 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.754623 | 0.122 |
| R-HSA-72306 | tRNA processing | 0.754623 | 0.122 |
| R-HSA-418555 | G alpha (s) signalling events | 0.756451 | 0.121 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.763629 | 0.117 |
| R-HSA-611105 | Respiratory electron transport | 0.768874 | 0.114 |
| R-HSA-168255 | Influenza Infection | 0.770597 | 0.113 |
| R-HSA-3781865 | Diseases of glycosylation | 0.779022 | 0.108 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.785540 | 0.105 |
| R-HSA-68877 | Mitotic Prometaphase | 0.793420 | 0.100 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.802468 | 0.096 |
| R-HSA-913531 | Interferon Signaling | 0.802468 | 0.096 |
| R-HSA-1643685 | Disease | 0.803881 | 0.095 |
| R-HSA-428157 | Sphingolipid metabolism | 0.805436 | 0.094 |
| R-HSA-1280218 | Adaptive Immune System | 0.807404 | 0.093 |
| R-HSA-9640148 | Infection with Enterobacteria | 0.808329 | 0.092 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.808329 | 0.092 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.810168 | 0.091 |
| R-HSA-392499 | Metabolism of proteins | 0.810424 | 0.091 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.817601 | 0.087 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.822171 | 0.085 |
| R-HSA-8978868 | Fatty acid metabolism | 0.827773 | 0.082 |
| R-HSA-8951664 | Neddylation | 0.833779 | 0.079 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.842083 | 0.075 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.842284 | 0.075 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.844634 | 0.073 |
| R-HSA-5668914 | Diseases of metabolism | 0.846611 | 0.072 |
| R-HSA-72312 | rRNA processing | 0.846949 | 0.072 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.863257 | 0.064 |
| R-HSA-9609646 | HCMV Infection | 0.866305 | 0.062 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.869870 | 0.061 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.874109 | 0.058 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.877367 | 0.057 |
| R-HSA-556833 | Metabolism of lipids | 0.878549 | 0.056 |
| R-HSA-416476 | G alpha (q) signalling events | 0.879664 | 0.056 |
| R-HSA-74160 | Gene expression (Transcription) | 0.882727 | 0.054 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.888387 | 0.051 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.891698 | 0.050 |
| R-HSA-9658195 | Leishmania infection | 0.894117 | 0.049 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.894117 | 0.049 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.897597 | 0.047 |
| R-HSA-1483257 | Phospholipid metabolism | 0.904716 | 0.043 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.921093 | 0.036 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.922860 | 0.035 |
| R-HSA-1474244 | Extracellular matrix organization | 0.927383 | 0.033 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.932668 | 0.030 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.936620 | 0.028 |
| R-HSA-388396 | GPCR downstream signalling | 0.936860 | 0.028 |
| R-HSA-73894 | DNA Repair | 0.941682 | 0.026 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.943421 | 0.025 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.950652 | 0.022 |
| R-HSA-212436 | Generic Transcription Pathway | 0.952078 | 0.021 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.952191 | 0.021 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.955266 | 0.020 |
| R-HSA-372790 | Signaling by GPCR | 0.960488 | 0.018 |
| R-HSA-1266738 | Developmental Biology | 0.962182 | 0.017 |
| R-HSA-112316 | Neuronal System | 0.974515 | 0.011 |
| R-HSA-211859 | Biological oxidations | 0.983254 | 0.007 |
| R-HSA-500792 | GPCR ligand binding | 0.989902 | 0.004 |
| R-HSA-1430728 | Metabolism | 0.999567 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999937 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CDC7 |
0.784 | 0.167 | 1 | 0.871 |
MOS |
0.781 | 0.180 | 1 | 0.889 |
COT |
0.780 | 0.044 | 2 | 0.447 |
KIS |
0.777 | 0.081 | 1 | 0.639 |
FAM20C |
0.774 | 0.036 | 2 | 0.306 |
GRK1 |
0.773 | 0.128 | -2 | 0.765 |
GCN2 |
0.771 | -0.055 | 2 | 0.462 |
PRPK |
0.771 | -0.019 | -1 | 0.835 |
BMPR1B |
0.771 | 0.174 | 1 | 0.820 |
IKKB |
0.770 | 0.030 | -2 | 0.677 |
DSTYK |
0.769 | -0.016 | 2 | 0.461 |
NEK6 |
0.768 | 0.052 | -2 | 0.822 |
NDR2 |
0.768 | 0.078 | -3 | 0.667 |
MST4 |
0.767 | 0.119 | 2 | 0.589 |
CLK3 |
0.767 | 0.041 | 1 | 0.784 |
PDHK1 |
0.766 | 0.052 | 1 | 0.815 |
GRK5 |
0.765 | 0.048 | -3 | 0.726 |
TGFBR2 |
0.765 | 0.046 | -2 | 0.786 |
PDHK4 |
0.765 | -0.065 | 1 | 0.822 |
BMPR2 |
0.765 | 0.016 | -2 | 0.824 |
CAMK2G |
0.765 | -0.050 | 2 | 0.429 |
MTOR |
0.765 | -0.050 | 1 | 0.735 |
IKKA |
0.764 | 0.072 | -2 | 0.687 |
RAF1 |
0.764 | -0.020 | 1 | 0.821 |
MLK1 |
0.764 | -0.001 | 2 | 0.465 |
ULK2 |
0.763 | -0.089 | 2 | 0.435 |
TBK1 |
0.762 | -0.040 | 1 | 0.715 |
HIPK4 |
0.762 | 0.054 | 1 | 0.743 |
BCKDK |
0.762 | 0.011 | -1 | 0.816 |
NEK7 |
0.762 | -0.007 | -3 | 0.703 |
NLK |
0.761 | -0.002 | 1 | 0.775 |
GRK7 |
0.761 | 0.133 | 1 | 0.729 |
ERK5 |
0.760 | 0.015 | 1 | 0.765 |
PIM3 |
0.760 | -0.027 | -3 | 0.675 |
BMPR1A |
0.760 | 0.172 | 1 | 0.814 |
GRK4 |
0.760 | 0.025 | -2 | 0.807 |
TGFBR1 |
0.759 | 0.091 | -2 | 0.818 |
ALK2 |
0.759 | 0.142 | -2 | 0.826 |
PRP4 |
0.759 | 0.252 | -3 | 0.866 |
CHAK2 |
0.758 | -0.014 | -1 | 0.814 |
IKKE |
0.758 | -0.052 | 1 | 0.709 |
CDKL5 |
0.758 | 0.001 | -3 | 0.649 |
CDKL1 |
0.758 | -0.037 | -3 | 0.657 |
CAMK1B |
0.757 | -0.080 | -3 | 0.699 |
GRK6 |
0.757 | 0.024 | 1 | 0.822 |
CK1E |
0.756 | 0.053 | -3 | 0.446 |
TTBK2 |
0.755 | -0.046 | 2 | 0.378 |
WNK1 |
0.755 | -0.039 | -2 | 0.796 |
ATR |
0.755 | -0.054 | 1 | 0.746 |
NUAK2 |
0.755 | -0.023 | -3 | 0.676 |
PRKD1 |
0.754 | 0.011 | -3 | 0.649 |
ACVR2A |
0.754 | 0.095 | -2 | 0.770 |
NEK9 |
0.753 | -0.022 | 2 | 0.491 |
RIPK3 |
0.753 | -0.044 | 3 | 0.706 |
ALK4 |
0.753 | 0.044 | -2 | 0.826 |
MLK3 |
0.753 | -0.016 | 2 | 0.420 |
PKR |
0.753 | 0.127 | 1 | 0.806 |
PKN3 |
0.753 | -0.077 | -3 | 0.678 |
ULK1 |
0.753 | -0.130 | -3 | 0.682 |
ACVR2B |
0.752 | 0.089 | -2 | 0.786 |
IRE1 |
0.752 | -0.032 | 1 | 0.751 |
CDK8 |
0.751 | 0.014 | 1 | 0.609 |
LATS2 |
0.751 | -0.002 | -5 | 0.718 |
TLK2 |
0.751 | 0.105 | 1 | 0.749 |
SKMLCK |
0.751 | -0.035 | -2 | 0.758 |
NDR1 |
0.751 | -0.043 | -3 | 0.665 |
RSK2 |
0.751 | -0.023 | -3 | 0.620 |
NIK |
0.751 | -0.108 | -3 | 0.720 |
CAMK2D |
0.750 | -0.051 | -3 | 0.676 |
SRPK1 |
0.750 | -0.008 | -3 | 0.611 |
DLK |
0.750 | -0.065 | 1 | 0.802 |
CK1D |
0.749 | 0.074 | -3 | 0.399 |
CAMK2B |
0.748 | -0.019 | 2 | 0.418 |
PKN2 |
0.748 | -0.072 | -3 | 0.675 |
HUNK |
0.748 | -0.120 | 2 | 0.402 |
WNK3 |
0.748 | -0.129 | 1 | 0.776 |
CK2A2 |
0.748 | 0.148 | 1 | 0.750 |
ANKRD3 |
0.747 | -0.071 | 1 | 0.809 |
CK1G1 |
0.747 | 0.042 | -3 | 0.440 |
PRKD2 |
0.747 | -0.015 | -3 | 0.597 |
ICK |
0.747 | -0.026 | -3 | 0.679 |
CAMLCK |
0.746 | -0.087 | -2 | 0.723 |
MLK4 |
0.746 | -0.043 | 2 | 0.409 |
RIPK1 |
0.746 | -0.087 | 1 | 0.769 |
MARK4 |
0.746 | -0.087 | 4 | 0.779 |
AURC |
0.746 | 0.020 | -2 | 0.504 |
MLK2 |
0.746 | -0.074 | 2 | 0.465 |
CDK19 |
0.745 | 0.010 | 1 | 0.569 |
RSK3 |
0.745 | -0.039 | -3 | 0.617 |
PLK1 |
0.745 | -0.049 | -2 | 0.762 |
PIM1 |
0.745 | -0.034 | -3 | 0.616 |
AMPKA1 |
0.745 | -0.078 | -3 | 0.683 |
P90RSK |
0.745 | -0.052 | -3 | 0.629 |
TSSK1 |
0.745 | 0.001 | -3 | 0.709 |
DAPK2 |
0.744 | -0.095 | -3 | 0.713 |
VRK2 |
0.744 | 0.022 | 1 | 0.838 |
TSSK2 |
0.744 | -0.073 | -5 | 0.798 |
CDK5 |
0.744 | 0.029 | 1 | 0.625 |
P70S6KB |
0.744 | -0.045 | -3 | 0.636 |
SRPK3 |
0.744 | -0.012 | -3 | 0.585 |
MAPKAPK2 |
0.743 | -0.015 | -3 | 0.555 |
CDK1 |
0.743 | 0.029 | 1 | 0.562 |
MASTL |
0.743 | -0.191 | -2 | 0.742 |
LATS1 |
0.742 | -0.016 | -3 | 0.689 |
CDK13 |
0.742 | 0.018 | 1 | 0.584 |
PKCD |
0.742 | -0.082 | 2 | 0.435 |
ATM |
0.742 | -0.052 | 1 | 0.682 |
SRPK2 |
0.741 | -0.026 | -3 | 0.537 |
PERK |
0.741 | -0.020 | -2 | 0.805 |
DYRK2 |
0.741 | -0.002 | 1 | 0.649 |
PKACG |
0.741 | -0.050 | -2 | 0.602 |
YSK4 |
0.741 | -0.050 | 1 | 0.746 |
CAMK2A |
0.741 | -0.051 | 2 | 0.417 |
HIPK2 |
0.740 | 0.048 | 1 | 0.560 |
ERK1 |
0.740 | 0.024 | 1 | 0.565 |
CK1A2 |
0.740 | 0.047 | -3 | 0.398 |
MEKK3 |
0.740 | -0.020 | 1 | 0.773 |
IRE2 |
0.739 | -0.093 | 2 | 0.407 |
MEK1 |
0.739 | -0.116 | 2 | 0.463 |
MAPKAPK3 |
0.739 | -0.086 | -3 | 0.598 |
NEK2 |
0.739 | -0.058 | 2 | 0.473 |
PKCA |
0.738 | -0.057 | 2 | 0.412 |
CDK7 |
0.738 | -0.009 | 1 | 0.614 |
PKCB |
0.737 | -0.064 | 2 | 0.405 |
PHKG1 |
0.737 | -0.077 | -3 | 0.653 |
CDK18 |
0.737 | 0.012 | 1 | 0.532 |
JNK3 |
0.737 | 0.009 | 1 | 0.593 |
GRK2 |
0.737 | -0.020 | -2 | 0.688 |
AMPKA2 |
0.737 | -0.086 | -3 | 0.649 |
PLK3 |
0.737 | -0.068 | 2 | 0.379 |
MNK2 |
0.737 | -0.061 | -2 | 0.648 |
CK2A1 |
0.736 | 0.121 | 1 | 0.722 |
RSK4 |
0.736 | -0.029 | -3 | 0.590 |
NIM1 |
0.736 | -0.134 | 3 | 0.746 |
CDK12 |
0.736 | 0.024 | 1 | 0.557 |
HIPK1 |
0.736 | 0.026 | 1 | 0.664 |
TLK1 |
0.735 | -0.031 | -2 | 0.822 |
PKCG |
0.735 | -0.083 | 2 | 0.397 |
NUAK1 |
0.735 | -0.063 | -3 | 0.615 |
MEKK1 |
0.735 | -0.021 | 1 | 0.781 |
PAK1 |
0.735 | -0.085 | -2 | 0.635 |
AURA |
0.735 | -0.007 | -2 | 0.463 |
P38B |
0.735 | 0.022 | 1 | 0.575 |
P38A |
0.735 | 0.015 | 1 | 0.644 |
MEKK2 |
0.735 | -0.011 | 2 | 0.452 |
P38G |
0.734 | 0.022 | 1 | 0.477 |
ZAK |
0.734 | -0.049 | 1 | 0.751 |
JNK2 |
0.734 | 0.014 | 1 | 0.559 |
CHAK1 |
0.734 | -0.105 | 2 | 0.418 |
HRI |
0.734 | -0.084 | -2 | 0.797 |
CLK4 |
0.734 | -0.036 | -3 | 0.611 |
WNK4 |
0.734 | -0.029 | -2 | 0.799 |
CDK9 |
0.733 | 0.002 | 1 | 0.590 |
MST3 |
0.733 | 0.036 | 2 | 0.487 |
PLK4 |
0.733 | -0.102 | 2 | 0.334 |
PRKD3 |
0.732 | -0.059 | -3 | 0.572 |
AURB |
0.732 | -0.027 | -2 | 0.494 |
PKCH |
0.732 | -0.105 | 2 | 0.394 |
PKCZ |
0.732 | -0.077 | 2 | 0.430 |
GRK3 |
0.732 | 0.015 | -2 | 0.663 |
ERK2 |
0.731 | -0.016 | 1 | 0.606 |
MPSK1 |
0.731 | 0.030 | 1 | 0.744 |
BRAF |
0.731 | -0.077 | -4 | 0.583 |
CAMK4 |
0.731 | -0.156 | -3 | 0.642 |
GSK3A |
0.731 | 0.053 | 4 | 0.461 |
CLK2 |
0.731 | -0.000 | -3 | 0.598 |
ERK7 |
0.730 | -0.021 | 2 | 0.322 |
MSK2 |
0.730 | -0.095 | -3 | 0.581 |
PAK3 |
0.730 | -0.127 | -2 | 0.630 |
SMG1 |
0.730 | -0.081 | 1 | 0.686 |
P38D |
0.730 | 0.036 | 1 | 0.489 |
CLK1 |
0.729 | -0.039 | -3 | 0.583 |
TTBK1 |
0.729 | -0.099 | 2 | 0.315 |
PKACB |
0.729 | -0.031 | -2 | 0.525 |
MEK5 |
0.729 | -0.120 | 2 | 0.464 |
CDK2 |
0.729 | -0.027 | 1 | 0.636 |
CDK3 |
0.728 | 0.027 | 1 | 0.499 |
DYRK1A |
0.728 | -0.016 | 1 | 0.681 |
NEK5 |
0.728 | -0.042 | 1 | 0.780 |
CK1A |
0.727 | 0.075 | -3 | 0.323 |
PRKX |
0.727 | -0.017 | -3 | 0.528 |
MNK1 |
0.727 | -0.092 | -2 | 0.656 |
TAO3 |
0.727 | 0.003 | 1 | 0.757 |
QSK |
0.727 | -0.085 | 4 | 0.745 |
SGK3 |
0.727 | -0.059 | -3 | 0.610 |
AKT2 |
0.727 | -0.032 | -3 | 0.542 |
MELK |
0.727 | -0.121 | -3 | 0.635 |
DNAPK |
0.727 | -0.069 | 1 | 0.588 |
PKG2 |
0.727 | -0.055 | -2 | 0.523 |
PAK2 |
0.727 | -0.110 | -2 | 0.619 |
MSK1 |
0.726 | -0.071 | -3 | 0.590 |
QIK |
0.726 | -0.158 | -3 | 0.672 |
EEF2K |
0.726 | 0.020 | 3 | 0.807 |
CDK17 |
0.726 | -0.010 | 1 | 0.478 |
PASK |
0.726 | -0.028 | -3 | 0.694 |
HIPK3 |
0.726 | -0.021 | 1 | 0.672 |
GAK |
0.725 | 0.046 | 1 | 0.790 |
IRAK4 |
0.725 | -0.111 | 1 | 0.763 |
BRSK1 |
0.725 | -0.120 | -3 | 0.620 |
BRSK2 |
0.725 | -0.133 | -3 | 0.641 |
PINK1 |
0.724 | -0.121 | 1 | 0.769 |
GSK3B |
0.724 | -0.004 | 4 | 0.448 |
DCAMKL1 |
0.724 | -0.070 | -3 | 0.613 |
CHK1 |
0.723 | -0.098 | -3 | 0.648 |
PIM2 |
0.723 | -0.051 | -3 | 0.590 |
PAK6 |
0.723 | -0.094 | -2 | 0.530 |
MAPKAPK5 |
0.723 | -0.111 | -3 | 0.571 |
SNRK |
0.723 | -0.204 | 2 | 0.359 |
PLK2 |
0.723 | -0.016 | -3 | 0.657 |
DYRK4 |
0.722 | -0.029 | 1 | 0.571 |
MYLK4 |
0.721 | -0.112 | -2 | 0.634 |
P70S6K |
0.721 | -0.040 | -3 | 0.557 |
SIK |
0.721 | -0.099 | -3 | 0.586 |
DRAK1 |
0.721 | -0.135 | 1 | 0.689 |
MARK2 |
0.721 | -0.108 | 4 | 0.676 |
NEK11 |
0.720 | -0.086 | 1 | 0.743 |
MARK3 |
0.720 | -0.105 | 4 | 0.706 |
LKB1 |
0.720 | -0.005 | -3 | 0.727 |
CDK16 |
0.719 | -0.013 | 1 | 0.497 |
CAMK1G |
0.718 | -0.116 | -3 | 0.599 |
MINK |
0.718 | 0.012 | 1 | 0.764 |
SSTK |
0.718 | -0.106 | 4 | 0.740 |
MST2 |
0.717 | -0.046 | 1 | 0.782 |
GCK |
0.717 | -0.000 | 1 | 0.762 |
NEK8 |
0.717 | -0.112 | 2 | 0.451 |
PKCT |
0.717 | -0.105 | 2 | 0.407 |
CAMKK1 |
0.717 | -0.103 | -2 | 0.670 |
TAO2 |
0.717 | -0.077 | 2 | 0.467 |
DCAMKL2 |
0.717 | -0.120 | -3 | 0.631 |
DYRK3 |
0.716 | -0.037 | 1 | 0.673 |
IRAK1 |
0.716 | -0.162 | -1 | 0.760 |
JNK1 |
0.716 | -0.003 | 1 | 0.539 |
PHKG2 |
0.716 | -0.124 | -3 | 0.631 |
TNIK |
0.716 | 0.006 | 3 | 0.833 |
CDK14 |
0.715 | -0.040 | 1 | 0.574 |
PKCI |
0.715 | -0.092 | 2 | 0.432 |
TAK1 |
0.715 | -0.045 | 1 | 0.796 |
HGK |
0.715 | -0.019 | 3 | 0.823 |
DYRK1B |
0.715 | -0.031 | 1 | 0.592 |
CDK10 |
0.714 | -0.023 | 1 | 0.559 |
AKT1 |
0.714 | -0.049 | -3 | 0.555 |
MEKK6 |
0.714 | -0.077 | 1 | 0.763 |
MAP3K15 |
0.713 | -0.078 | 1 | 0.728 |
PKACA |
0.713 | -0.053 | -2 | 0.463 |
MARK1 |
0.713 | -0.145 | 4 | 0.729 |
PDK1 |
0.712 | -0.089 | 1 | 0.749 |
NEK4 |
0.712 | -0.099 | 1 | 0.757 |
VRK1 |
0.712 | -0.081 | 2 | 0.426 |
PKCE |
0.711 | -0.078 | 2 | 0.394 |
LRRK2 |
0.711 | -0.100 | 2 | 0.475 |
MAK |
0.711 | 0.025 | -2 | 0.639 |
SMMLCK |
0.711 | -0.133 | -3 | 0.659 |
CAMKK2 |
0.711 | -0.089 | -2 | 0.646 |
HPK1 |
0.709 | -0.031 | 1 | 0.743 |
NEK1 |
0.709 | -0.069 | 1 | 0.764 |
YSK1 |
0.708 | -0.010 | 2 | 0.496 |
KHS1 |
0.708 | 0.001 | 1 | 0.747 |
KHS2 |
0.708 | 0.014 | 1 | 0.749 |
OSR1 |
0.708 | 0.041 | 2 | 0.494 |
MOK |
0.707 | 0.004 | 1 | 0.679 |
STK33 |
0.707 | -0.121 | 2 | 0.322 |
CDK6 |
0.706 | -0.026 | 1 | 0.556 |
TTK |
0.706 | -0.005 | -2 | 0.796 |
CAMK1D |
0.705 | -0.100 | -3 | 0.511 |
SGK1 |
0.705 | -0.037 | -3 | 0.473 |
NEK3 |
0.705 | -0.010 | 1 | 0.732 |
YANK3 |
0.705 | -0.052 | 2 | 0.200 |
PDHK3_TYR |
0.705 | 0.054 | 4 | 0.869 |
MST1 |
0.705 | -0.093 | 1 | 0.759 |
DAPK3 |
0.704 | -0.087 | -3 | 0.633 |
LOK |
0.704 | -0.070 | -2 | 0.640 |
CK1G3 |
0.704 | 0.062 | -3 | 0.284 |
CDK4 |
0.704 | -0.030 | 1 | 0.542 |
BUB1 |
0.704 | -0.011 | -5 | 0.747 |
CHK2 |
0.703 | -0.068 | -3 | 0.486 |
PKN1 |
0.703 | -0.103 | -3 | 0.570 |
MEK2 |
0.702 | -0.153 | 2 | 0.468 |
AKT3 |
0.701 | -0.043 | -3 | 0.484 |
MAP2K4_TYR |
0.700 | 0.078 | -1 | 0.862 |
PAK5 |
0.700 | -0.106 | -2 | 0.459 |
RIPK2 |
0.700 | -0.180 | 1 | 0.716 |
PBK |
0.699 | -0.038 | 1 | 0.717 |
DAPK1 |
0.699 | -0.085 | -3 | 0.624 |
PDHK1_TYR |
0.699 | 0.045 | -1 | 0.885 |
PDHK4_TYR |
0.698 | 0.031 | 2 | 0.472 |
ALPHAK3 |
0.698 | -0.019 | -1 | 0.769 |
MAP2K6_TYR |
0.698 | 0.008 | -1 | 0.872 |
ROCK2 |
0.697 | -0.063 | -3 | 0.623 |
SLK |
0.697 | -0.092 | -2 | 0.597 |
TESK1_TYR |
0.696 | -0.056 | 3 | 0.847 |
MRCKB |
0.696 | -0.069 | -3 | 0.577 |
PAK4 |
0.696 | -0.110 | -2 | 0.463 |
PKMYT1_TYR |
0.695 | -0.015 | 3 | 0.810 |
MYO3B |
0.695 | -0.009 | 2 | 0.489 |
BMPR2_TYR |
0.694 | -0.009 | -1 | 0.867 |
SBK |
0.693 | -0.058 | -3 | 0.430 |
HASPIN |
0.693 | -0.032 | -1 | 0.660 |
MRCKA |
0.693 | -0.087 | -3 | 0.587 |
MAP2K7_TYR |
0.692 | -0.135 | 2 | 0.460 |
CRIK |
0.690 | -0.009 | -3 | 0.549 |
CAMK1A |
0.690 | -0.104 | -3 | 0.488 |
ASK1 |
0.689 | -0.119 | 1 | 0.718 |
MYO3A |
0.689 | -0.051 | 1 | 0.749 |
EPHA6 |
0.689 | -0.048 | -1 | 0.873 |
PINK1_TYR |
0.688 | -0.164 | 1 | 0.804 |
LIMK2_TYR |
0.687 | -0.044 | -3 | 0.740 |
PKG1 |
0.687 | -0.083 | -2 | 0.435 |
FER |
0.686 | -0.025 | 1 | 0.867 |
TAO1 |
0.686 | -0.076 | 1 | 0.697 |
FGR |
0.685 | -0.014 | 1 | 0.823 |
EPHB4 |
0.685 | -0.054 | -1 | 0.846 |
DMPK1 |
0.685 | -0.078 | -3 | 0.597 |
BIKE |
0.685 | -0.041 | 1 | 0.662 |
EPHA4 |
0.684 | -0.036 | 2 | 0.372 |
TYK2 |
0.684 | -0.096 | 1 | 0.769 |
TXK |
0.684 | 0.014 | 1 | 0.848 |
CK1G2 |
0.683 | 0.044 | -3 | 0.367 |
ROS1 |
0.683 | -0.091 | 3 | 0.731 |
ROCK1 |
0.683 | -0.082 | -3 | 0.591 |
HCK |
0.682 | -0.020 | -1 | 0.823 |
STLK3 |
0.682 | -0.076 | 1 | 0.727 |
LIMK1_TYR |
0.682 | -0.149 | 2 | 0.468 |
LCK |
0.681 | 0.021 | -1 | 0.829 |
JAK2 |
0.681 | -0.082 | 1 | 0.767 |
RET |
0.681 | -0.134 | 1 | 0.765 |
BLK |
0.681 | 0.028 | -1 | 0.830 |
ABL2 |
0.680 | -0.042 | -1 | 0.812 |
SRMS |
0.680 | -0.056 | 1 | 0.857 |
ITK |
0.680 | -0.042 | -1 | 0.803 |
TNNI3K_TYR |
0.680 | -0.011 | 1 | 0.821 |
TYRO3 |
0.679 | -0.145 | 3 | 0.752 |
YES1 |
0.679 | -0.050 | -1 | 0.826 |
CSF1R |
0.679 | -0.092 | 3 | 0.742 |
ABL1 |
0.679 | -0.041 | -1 | 0.806 |
MST1R |
0.678 | -0.126 | 3 | 0.748 |
EPHB2 |
0.677 | -0.051 | -1 | 0.835 |
EPHB1 |
0.677 | -0.080 | 1 | 0.847 |
EPHB3 |
0.677 | -0.060 | -1 | 0.837 |
FYN |
0.675 | 0.006 | -1 | 0.796 |
INSRR |
0.675 | -0.099 | 3 | 0.698 |
YANK2 |
0.674 | -0.053 | 2 | 0.205 |
PDGFRB |
0.674 | -0.138 | 3 | 0.746 |
JAK3 |
0.674 | -0.104 | 1 | 0.744 |
DDR1 |
0.673 | -0.186 | 4 | 0.798 |
SYK |
0.673 | 0.064 | -1 | 0.798 |
PTK6 |
0.672 | -0.097 | -1 | 0.743 |
PTK2 |
0.671 | 0.013 | -1 | 0.816 |
MERTK |
0.670 | -0.091 | 3 | 0.725 |
TNK2 |
0.670 | -0.110 | 3 | 0.685 |
KIT |
0.670 | -0.110 | 3 | 0.741 |
EPHA7 |
0.670 | -0.069 | 2 | 0.371 |
JAK1 |
0.670 | -0.068 | 1 | 0.711 |
FGFR2 |
0.668 | -0.158 | 3 | 0.731 |
NEK10_TYR |
0.667 | -0.074 | 1 | 0.635 |
TEC |
0.667 | -0.081 | -1 | 0.720 |
MET |
0.667 | -0.074 | 3 | 0.719 |
FLT3 |
0.667 | -0.169 | 3 | 0.742 |
EPHA3 |
0.667 | -0.110 | 2 | 0.360 |
BMX |
0.667 | -0.071 | -1 | 0.692 |
WEE1_TYR |
0.667 | -0.083 | -1 | 0.732 |
LYN |
0.666 | -0.053 | 3 | 0.673 |
FLT1 |
0.666 | -0.064 | -1 | 0.875 |
AAK1 |
0.666 | -0.012 | 1 | 0.553 |
AXL |
0.666 | -0.143 | 3 | 0.716 |
PDGFRA |
0.666 | -0.189 | 3 | 0.750 |
KDR |
0.665 | -0.124 | 3 | 0.695 |
BTK |
0.665 | -0.155 | -1 | 0.764 |
ERBB2 |
0.665 | -0.106 | 1 | 0.722 |
FRK |
0.665 | -0.090 | -1 | 0.838 |
FGFR1 |
0.664 | -0.165 | 3 | 0.701 |
EPHA5 |
0.664 | -0.071 | 2 | 0.349 |
TNK1 |
0.664 | -0.142 | 3 | 0.739 |
TEK |
0.663 | -0.181 | 3 | 0.696 |
ALK |
0.663 | -0.141 | 3 | 0.656 |
SRC |
0.662 | -0.040 | -1 | 0.794 |
NTRK1 |
0.662 | -0.153 | -1 | 0.827 |
LTK |
0.662 | -0.136 | 3 | 0.680 |
PTK2B |
0.662 | -0.086 | -1 | 0.765 |
EGFR |
0.662 | -0.055 | 1 | 0.639 |
INSR |
0.661 | -0.122 | 3 | 0.679 |
EPHA8 |
0.659 | -0.083 | -1 | 0.820 |
FLT4 |
0.658 | -0.153 | 3 | 0.706 |
EPHA1 |
0.658 | -0.150 | 3 | 0.694 |
MATK |
0.657 | -0.105 | -1 | 0.743 |
FGFR3 |
0.657 | -0.154 | 3 | 0.700 |
NTRK2 |
0.657 | -0.164 | 3 | 0.695 |
NTRK3 |
0.656 | -0.116 | -1 | 0.775 |
FGFR4 |
0.656 | -0.073 | -1 | 0.789 |
EPHA2 |
0.654 | -0.071 | -1 | 0.795 |
CSK |
0.653 | -0.132 | 2 | 0.379 |
DDR2 |
0.651 | -0.126 | 3 | 0.666 |
ERBB4 |
0.649 | -0.058 | 1 | 0.670 |
IGF1R |
0.648 | -0.109 | 3 | 0.624 |
MUSK |
0.641 | -0.149 | 1 | 0.612 |
ZAP70 |
0.637 | -0.018 | -1 | 0.692 |
FES |
0.633 | -0.124 | -1 | 0.683 |