Motif 868 (n=147)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0U1RQJ8 | ATRIP | S331 | ochoa | ATR interacting protein | None |
| A4D2B0 | MBLAC1 | S65 | ochoa | Metallo-beta-lactamase domain-containing protein 1 (EC 3.1.27.-) (Endoribonuclease MBLAC1) | Endoribonuclease that catalyzes the hydrolysis of histone-coding pre-mRNA 3'-end. Involved in histone pre-mRNA processing during the S-phase of the cell cycle, which is required for entering/progressing through S-phase (PubMed:30507380). Cleaves histone pre-mRNA at a major and a minor cleavage site after the 5'-ACCCA-3' and the 5'-ACCCACA-3' sequence, respectively, and located downstream of the stem-loop (PubMed:30507380). May require the presence of the HDE element located at the histone pre-RNA 3'-end to avoid non-specific cleavage (PubMed:30507380). {ECO:0000269|PubMed:30507380}. |
| A7E2V4 | ZSWIM8 | S1060 | ochoa | Zinc finger SWIM domain-containing protein 8 | Substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex that promotes target-directed microRNA degradation (TDMD), a process that mediates degradation of microRNAs (miRNAs) (PubMed:33184234, PubMed:33184237). The SCF-like E3 ubiquitin-protein ligase complex acts by catalyzing ubiquitination and subsequent degradation of AGO proteins (AGO1, AGO2, AGO3 and/or AGO4), thereby exposing miRNAs for degradation (PubMed:33184234, PubMed:33184237). Specifically recognizes and binds AGO proteins when they are engaged with a TDMD target (PubMed:33184234). May also act as a regulator of axon guidance: specifically recognizes misfolded ROBO3 and promotes its ubiquitination and subsequent degradation (PubMed:24012004). Plays an essential role for proper embryonic development of heart and lung (By similarity). Controls protein quality of DAB1, a key signal molecule for brain development, thus protecting its signaling strength. Mechanistically, recognizes intrinsically disordered regions of DAB1 and eliminates misfolded DAB1 that cannot be properly phosphorylated (By similarity). {ECO:0000250|UniProtKB:Q3UHH1, ECO:0000269|PubMed:24012004, ECO:0000269|PubMed:33184234, ECO:0000269|PubMed:33184237}.; FUNCTION: (Microbial infection) Participates in Zika virus inhibition of IFN signaling by acting as a scaffold protein to connect ZSWIM8/CUL3 ligase complex and STAT2, leading to STAT2 degradation. {ECO:0000269|PubMed:39145933}. |
| E7EW31 | PROB1 | S236 | ochoa | Proline-rich basic protein 1 | None |
| O00159 | MYO1C | S29 | ochoa | Unconventional myosin-Ic (Myosin I beta) (MMI-beta) (MMIb) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes. {ECO:0000269|PubMed:24636949}.; FUNCTION: [Isoform 3]: Involved in regulation of transcription. Associated with transcriptional active ribosomal genes. Appears to cooperate with the WICH chromatin-remodeling complex to facilitate transcription. Necessary for the formation of the first phosphodiester bond during transcription initiation. {ECO:0000250|UniProtKB:Q9WTI7}. |
| O14818 | PSMA7 | S150 | ochoa | Proteasome subunit alpha type-7 (Proteasome subunit RC6-1) (Proteasome subunit XAPC7) (Proteasome subunit alpha-4) (alpha-4) | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response. {ECO:0000269|PubMed:11389899, ECO:0000269|PubMed:11713272, ECO:0000269|PubMed:12119296, ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:19442227, ECO:0000269|PubMed:19734229, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. |
| O15061 | SYNM | S471 | ochoa | Synemin (Desmuslin) | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}. |
| O60347 | TBC1D12 | S115 | ochoa | TBC1 domain family member 12 | RAB11A-binding protein that plays a role in neurite outgrowth. {ECO:0000250|UniProtKB:M0R7T9}. |
| O60936 | NOL3 | S120 | ochoa | Nucleolar protein 3 (Apoptosis repressor with CARD) (Muscle-enriched cytoplasmic protein) (Myp) (Nucleolar protein of 30 kDa) (Nop30) | [Isoform 1]: May be involved in RNA splicing. {ECO:0000269|PubMed:10196175}.; FUNCTION: [Isoform 2]: Functions as an apoptosis repressor that blocks multiple modes of cell death. Inhibits extrinsic apoptotic pathways through two different ways. Firstly by interacting with FAS and FADD upon FAS activation blocking death-inducing signaling complex (DISC) assembly (By similarity). Secondly by interacting with CASP8 in a mitochondria localization- and phosphorylation-dependent manner, limiting the amount of soluble CASP8 available for DISC-mediated activation (By similarity). Inhibits intrinsic apoptotic pathway in response to a wide range of stresses, through its interaction with BAX resulting in BAX inactivation, preventing mitochondrial dysfunction and release of pro-apoptotic factors (PubMed:15004034). Inhibits calcium-mediated cell death by functioning as a cytosolic calcium buffer, dissociating its interaction with CASP8 and maintaining calcium homeostasis (PubMed:15509781). Negatively regulates oxidative stress-induced apoptosis by phosphorylation-dependent suppression of the mitochondria-mediated intrinsic pathway, by blocking CASP2 activation and BAX translocation (By similarity). Negatively regulates hypoxia-induced apoptosis in part by inhibiting the release of cytochrome c from mitochondria in a caspase-independent manner (By similarity). Also inhibits TNF-induced necrosis by preventing TNF-signaling pathway through TNFRSF1A interaction abrogating the recruitment of RIPK1 to complex I (By similarity). Finally through its role as apoptosis repressor, promotes vascular remodeling through inhibition of apoptosis and stimulation of proliferation, in response to hypoxia (By similarity). Inhibits too myoblast differentiation through caspase inhibition (By similarity). {ECO:0000250|UniProtKB:Q62881, ECO:0000250|UniProtKB:Q9D1X0, ECO:0000269|PubMed:15004034, ECO:0000269|PubMed:15509781}. |
| O75044 | SRGAP2 | S822 | ochoa | SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2) (Rho GTPase-activating protein 34) | Postsynaptic RAC1 GTPase activating protein (GAP) that plays a key role in neuronal morphogenesis and migration mainly during development of the cerebral cortex (PubMed:20810653, PubMed:27373832, PubMed:28333212). Regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons (PubMed:22559944, PubMed:27373832). SRGAP2/SRGAP2A limits excitatory and inhibitory synapse density through its RAC1-specific GTPase activating activity, while it promotes maturation of both excitatory and inhibitory synapses through its ability to bind to the postsynaptic scaffolding protein HOMER1 at excitatory synapses, and the postsynaptic protein GPHN at inhibitory synapses (By similarity). Mechanistically, acts by binding and deforming membranes, thereby regulating actin dynamics to regulate cell migration and differentiation (PubMed:27373832). Promotes cell repulsion and contact inhibition of locomotion: localizes to protrusions with curved edges and controls the duration of RAC1 activity in contact protrusions (By similarity). In non-neuronal cells, may also play a role in cell migration by regulating the formation of lamellipodia and filopodia (PubMed:20810653, PubMed:21148482). {ECO:0000250|UniProtKB:Q91Z67, ECO:0000269|PubMed:20810653, ECO:0000269|PubMed:21148482, ECO:0000269|PubMed:22559944, ECO:0000269|PubMed:27373832, ECO:0000269|PubMed:28333212}. |
| O75116 | ROCK2 | S1134 | ochoa | Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho kinase 2) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2) | Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation. {ECO:0000269|PubMed:10579722, ECO:0000269|PubMed:15699075, ECO:0000269|PubMed:16574662, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21147781}. |
| O75151 | PHF2 | S929 | ochoa | Lysine-specific demethylase PHF2 (EC 1.14.11.-) (GRC5) (PHD finger protein 2) | Lysine demethylase that demethylates both histones and non-histone proteins (PubMed:20129925, PubMed:21167174, PubMed:21532585). Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B (PubMed:21532585). Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes (PubMed:21532585). The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA (PubMed:21532585). Involved in the activation of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages by catalyzing the demethylation of trimethylated histone H4 lysine 20 (H4K20me3) at the gene promoters (By similarity). {ECO:0000250|UniProtKB:Q9WTU0, ECO:0000269|PubMed:20129925, ECO:0000269|PubMed:21167174, ECO:0000269|PubMed:21532585}. |
| P04049 | RAF1 | S357 | ochoa|psp | RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) | Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}. |
| P08047 | SP1 | S732 | psp | Transcription factor Sp1 | Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Also binds the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component BMAL1 (PubMed:10391891, PubMed:11371615, PubMed:11904305, PubMed:14593115, PubMed:16377629, PubMed:16478997, PubMed:16943418, PubMed:17049555, PubMed:18171990, PubMed:18199680, PubMed:18239466, PubMed:18513490, PubMed:18619531, PubMed:19193796, PubMed:20091743, PubMed:21046154, PubMed:21798247). Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays a role in protecting cells against oxidative stress following brain injury by regulating the expression of RNF112 (By similarity). {ECO:0000250|UniProtKB:O89090, ECO:0000250|UniProtKB:Q01714, ECO:0000269|PubMed:10391891, ECO:0000269|PubMed:11371615, ECO:0000269|PubMed:11904305, ECO:0000269|PubMed:14593115, ECO:0000269|PubMed:16377629, ECO:0000269|PubMed:16478997, ECO:0000269|PubMed:16943418, ECO:0000269|PubMed:17049555, ECO:0000269|PubMed:18171990, ECO:0000269|PubMed:18199680, ECO:0000269|PubMed:18239466, ECO:0000269|PubMed:18513490, ECO:0000269|PubMed:18619531, ECO:0000269|PubMed:19193796, ECO:0000269|PubMed:20091743, ECO:0000269|PubMed:21046154, ECO:0000269|PubMed:21798247}. |
| P08913 | ADRA2A | S375 | psp | Alpha-2A adrenergic receptor (Alpha-2 adrenergic receptor subtype C10) (Alpha-2A adrenoreceptor) (Alpha-2A adrenoceptor) (Alpha-2AAR) | Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol. {ECO:0000269|PubMed:23105096}. |
| P0C7M8 | CLEC2L | S50 | ochoa | C-type lectin domain family 2 member L | None |
| P10070 | GLI2 | S941 | ochoa|psp | Zinc finger protein GLI2 (GLI family zinc finger protein 2) (Tax helper protein) | Functions as a transcription regulator in the hedgehog (Hh) pathway (PubMed:18455992, PubMed:26565916). Functions as a transcriptional activator (PubMed:19878745, PubMed:24311597, PubMed:9557682). May also function as transcriptional repressor (By similarity). Requires STK36 for full transcriptional activator activity. Required for normal embryonic development (PubMed:15994174, PubMed:20685856). {ECO:0000250|UniProtKB:Q0VGT2, ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:18455992, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:26565916, ECO:0000269|PubMed:9557682, ECO:0000305|PubMed:20685856}.; FUNCTION: [Isoform 1]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 2]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 3]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 4]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 1]: Acts as a transcriptional activator in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 2]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 3]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 4]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 5]: Acts as a transcriptional repressor. {ECO:0000269|PubMed:15994174}. |
| P11274 | BCR | S429 | ochoa | Breakpoint cluster region protein (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-26) | Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed:17116687, PubMed:1903516, PubMed:7479768). The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed:23940119, PubMed:7479768). The amino terminus contains an intrinsic kinase activity (PubMed:1657398). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity (PubMed:17116687). Plays a major role as a RHOA GEF in keratinocytes being involved in focal adhesion formation and keratinocyte differentiation (PubMed:23940119). {ECO:0000250|UniProtKB:Q6PAJ1, ECO:0000269|PubMed:1657398, ECO:0000269|PubMed:17116687, ECO:0000269|PubMed:1903516, ECO:0000269|PubMed:23940119, ECO:0000269|PubMed:7479768}. |
| P15056 | BRAF | S465 | ochoa|psp | Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) | Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). Phosphorylates PFKFB2 (PubMed:36402789). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179). {ECO:0000269|PubMed:1508179, ECO:0000269|PubMed:21441910, ECO:0000269|PubMed:29433126, ECO:0000269|PubMed:36402789, ECO:0000305}. |
| P19021 | PAM | S918 | ochoa | Peptidyl-glycine alpha-amidating monooxygenase (PAM) [Includes: Peptidylglycine alpha-hydroxylating monooxygenase (PHM) (EC 1.14.17.3); Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (EC 4.3.2.5) (Peptidylamidoglycolate lyase) (PAL)] | Bifunctional enzyme that catalyzes amidation of the C-terminus of proteins (PubMed:12699694, PubMed:2357221). Alpha-amidation is present at the C-terminus of many endocrine hormones and neuropeptides and is required for their activity (PubMed:1575450). C-terminal amidation also takes place in response to protein fragmentation triggered by oxidative stress, promoting degradation of amidated protein fragments by the proteasome (PubMed:2207077). Alpha-amidation involves two sequential reactions, both of which are catalyzed by separate catalytic domains of the enzyme (PubMed:12699694). The first step, catalyzed by peptidyl alpha-hydroxylating monooxygenase (PHM) domain, is the copper-, ascorbate-, and O2- dependent stereospecific hydroxylation (with S stereochemistry) at the alpha-carbon (C-alpha) of the C-terminal glycine of the peptidylglycine substrate (PubMed:12699694). The second step, catalyzed by the peptidylglycine amidoglycolate lyase (PAL) domain, is the zinc-dependent cleavage of the N-C-alpha bond, producing the alpha-amidated peptide and glyoxylate (PubMed:12699694). Similarly, catalyzes the two-step conversion of an N-fatty acylglycine to a primary fatty acid amide and glyoxylate (By similarity). {ECO:0000250|UniProtKB:P14925, ECO:0000269|PubMed:12699694, ECO:0000269|PubMed:2357221, ECO:0000303|PubMed:1575450, ECO:0000303|PubMed:2207077}. |
| P21399 | ACO1 | S711 | psp | Cytoplasmic aconitate hydratase (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) (Ferritin repressor protein) (Iron regulatory protein 1) (IRP1) (Iron-responsive element-binding protein 1) (IRE-BP 1) | Bifunctional iron sensor that switches between 2 activities depending on iron availability (PubMed:1281544, PubMed:1946430, PubMed:8041788). Iron deprivation, promotes its mRNA binding activity through which it regulates the expression of genes involved in iron uptake, sequestration and utilization (PubMed:1281544, PubMed:1946430, PubMed:23891004, PubMed:8041788). Binds to iron-responsive elements (IRES) in the untranslated region of target mRNAs preventing for instance the translation of ferritin and aminolevulinic acid synthase and stabilizing the transferrin receptor mRNA (PubMed:1281544, PubMed:1946430, PubMed:23891004, PubMed:8041788). {ECO:0000269|PubMed:1281544, ECO:0000269|PubMed:1946430, ECO:0000269|PubMed:23891004, ECO:0000269|PubMed:8041788}.; FUNCTION: Conversely, when cellular iron levels are high, binds a 4Fe-4S cluster which precludes RNA binding activity and promotes the aconitase activity, the isomerization of citrate to isocitrate via cis-aconitate. {ECO:0000269|PubMed:1281544, ECO:0000269|PubMed:1946430, ECO:0000269|PubMed:8041788}. |
| P22735 | TGM1 | S95 | ochoa | Protein-glutamine gamma-glutamyltransferase K (EC 2.3.2.13) (Epidermal TGase) (Transglutaminase K) (TG(K)) (TGK) (TGase K) (Transglutaminase-1) (TGase-1) | Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation (PubMed:26220141). {ECO:0000269|PubMed:26220141}. |
| P30518 | AVPR2 | S255 | psp | Vasopressin V2 receptor (V2R) (AVPR V2) (Antidiuretic hormone receptor) (Renal-type arginine vasopressin receptor) | Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption. {ECO:0000269|PubMed:19440390}. |
| P31277 | HOXD11 | S241 | ochoa | Homeobox protein Hox-D11 (Homeobox protein Hox-4F) | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. |
| P33991 | MCM4 | S120 | ochoa | DNA replication licensing factor MCM4 (EC 3.6.4.12) (CDC21 homolog) (P1-CDC21) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:25661590, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:16899510, PubMed:25661590, PubMed:32453425, PubMed:9305914). {ECO:0000269|PubMed:16899510, ECO:0000269|PubMed:25661590, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9305914}. |
| P35080 | PFN2 | S92 | ochoa | Profilin-2 (Profilin II) | Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. |
| P35637 | FUS | S340 | ochoa | RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein) | DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response (PubMed:27731383). Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing (PubMed:26124092). Also binds its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay (PubMed:24204307). Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (PubMed:10567410). In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity). {ECO:0000250|UniProtKB:P56959, ECO:0000269|PubMed:10567410, ECO:0000269|PubMed:21256132, ECO:0000269|PubMed:24204307, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27731383}. |
| P38935 | IGHMBP2 | S677 | ochoa | DNA-binding protein SMUBP-2 (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent helicase IGHMBP2) (Glial factor 1) (GF-1) (Immunoglobulin mu-binding protein 2) | 5' to 3' helicase that unwinds RNA and DNA duplexes in an ATP-dependent reaction (PubMed:19158098, PubMed:22999958, PubMed:30218034). Specific to 5'-phosphorylated single-stranded guanine-rich sequences (PubMed:22999958, PubMed:8349627). May play a role in RNA metabolism, ribosome biogenesis or initiation of translation (PubMed:19158098, PubMed:19299493). May play a role in regulation of transcription (By similarity). Interacts with tRNA-Tyr (PubMed:19299493). {ECO:0000250|UniProtKB:Q9EQN5, ECO:0000269|PubMed:19158098, ECO:0000269|PubMed:19299493, ECO:0000269|PubMed:22999958, ECO:0000269|PubMed:30218034, ECO:0000269|PubMed:8349627}. |
| P41180 | CASR | S875 | psp | Extracellular calcium-sensing receptor (CaR) (CaSR) (hCasR) (Parathyroid cell calcium-sensing receptor 1) (PCaR1) | G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis (PubMed:17555508, PubMed:19789209, PubMed:21566075, PubMed:22114145, PubMed:22789683, PubMed:23966241, PubMed:25104082, PubMed:25292184, PubMed:25766501, PubMed:26386835, PubMed:32817431, PubMed:33603117, PubMed:34194040, PubMed:34467854, PubMed:7759551, PubMed:8636323, PubMed:8702647, PubMed:8878438). Senses fluctuations in the circulating calcium concentration: activated by elevated circulating calcium, leading to decreased parathyroid hormone (PTH) secretion in parathyroid glands (By similarity). In kidneys, acts as a key regulator of renal tubular calcium resorption (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G-proteins) and modulates the activity of downstream effectors (PubMed:38632411). CASR is coupled with different G(q)/G(11), G(i)/G(o)- or G(s)-classes of G-proteins depending on the context (PubMed:38632411). In the parathyroid and kidney, CASR signals through G(q)/G(11) and G(i)/G(o) G-proteins: G(q)/G(11) coupling activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers, while G(i)/G(o) coupling mediates inhibition of adenylate cyclase activity (PubMed:38632411, PubMed:7759551). The G-protein-coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as Trp or Phe, act concertedly with divalent cations, such as calcium or magnesium, to achieve full receptor activation (PubMed:27386547, PubMed:27434672, PubMed:32817431, PubMed:33603117, PubMed:34194040). Acts as an activator of the NLRP3 inflammasome via G(i)/G(o)-mediated signaling: down-regulation of cyclic AMP (cAMP) relieving NLRP3 inhibition by cAMP (PubMed:32843625). Acts as a regulator of proton-sensing receptor GPR68 in a seesaw manner: CASR-mediated signaling inhibits GPR68 signaling in response to extracellular calcium, while GPR68 inhibits CASR in presence of extracellular protons (By similarity). {ECO:0000250|UniProtKB:P48442, ECO:0000250|UniProtKB:Q9QY96, ECO:0000269|PubMed:17555508, ECO:0000269|PubMed:19789209, ECO:0000269|PubMed:21566075, ECO:0000269|PubMed:22114145, ECO:0000269|PubMed:22789683, ECO:0000269|PubMed:23966241, ECO:0000269|PubMed:25104082, ECO:0000269|PubMed:25292184, ECO:0000269|PubMed:25766501, ECO:0000269|PubMed:26386835, ECO:0000269|PubMed:27386547, ECO:0000269|PubMed:27434672, ECO:0000269|PubMed:32817431, ECO:0000269|PubMed:32843625, ECO:0000269|PubMed:33603117, ECO:0000269|PubMed:34194040, ECO:0000269|PubMed:34467854, ECO:0000269|PubMed:38632411, ECO:0000269|PubMed:7759551, ECO:0000269|PubMed:8636323, ECO:0000269|PubMed:8702647, ECO:0000269|PubMed:8878438}. |
| P42166 | TMPO | S79 | ochoa | Lamina-associated polypeptide 2, isoform alpha (Thymopoietin isoform alpha) (TP alpha) (Thymopoietin-related peptide isoform alpha) (TPRP isoform alpha) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)] | May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.; FUNCTION: TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide. |
| P49069 | CAMLG | S20 | ochoa | Guided entry of tail-anchored proteins factor CAMLG (Calcium signal-modulating cyclophilin ligand) | Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (PubMed:23041287, PubMed:24392163, PubMed:27226539). Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol (PubMed:23041287, PubMed:24392163, PubMed:27226539). Required for the stability of GET1 (PubMed:32187542). Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium (PubMed:7522304). Essential for the survival of peripheral follicular B cells (By similarity). {ECO:0000250|UniProtKB:P49070, ECO:0000269|PubMed:23041287, ECO:0000269|PubMed:24392163, ECO:0000269|PubMed:27226539, ECO:0000269|PubMed:32187542, ECO:0000269|PubMed:7522304}. |
| P49247 | RPIA | S106 | ochoa | Ribose-5-phosphate isomerase (EC 5.3.1.6) (Phosphoriboisomerase) | Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate and participates in the first step of the non-oxidative branch of the pentose phosphate pathway. {ECO:0000269|PubMed:14988808}. |
| P49715 | CEBPA | S266 | ochoa | CCAAT/enhancer-binding protein alpha (C/EBP alpha) | Transcription factor that coordinates proliferation arrest and the differentiation of myeloid progenitors, adipocytes, hepatocytes, and cells of the lung and the placenta. Binds directly to the consensus DNA sequence 5'-T[TG]NNGNAA[TG]-3' acting as an activator on distinct target genes (PubMed:11242107). During early embryogenesis, plays essential and redundant functions with CEBPB. Essential for the transition from common myeloid progenitors (CMP) to granulocyte/monocyte progenitors (GMP). Critical for the proper development of the liver and the lung (By similarity). Necessary for terminal adipocyte differentiation, is required for postnatal maintenance of systemic energy homeostasis and lipid storage (By similarity). To regulate these different processes at the proper moment and tissue, interplays with other transcription factors and modulators. Down-regulates the expression of genes that maintain cells in an undifferentiated and proliferative state through E2F1 repression, which is critical for its ability to induce adipocyte and granulocyte terminal differentiation. Reciprocally E2F1 blocks adipocyte differentiation by binding to specific promoters and repressing CEBPA binding to its target gene promoters. Proliferation arrest also depends on a functional binding to SWI/SNF complex (PubMed:14660596). In liver, regulates gluconeogenesis and lipogenesis through different mechanisms. To regulate gluconeogenesis, functionally cooperates with FOXO1 binding to IRE-controlled promoters and regulating the expression of target genes such as PCK1 or G6PC1. To modulate lipogenesis, interacts and transcriptionally synergizes with SREBF1 in promoter activation of specific lipogenic target genes such as ACAS2. In adipose tissue, seems to act as FOXO1 coactivator accessing to ADIPOQ promoter through FOXO1 binding sites (By similarity). {ECO:0000250|UniProtKB:P05554, ECO:0000250|UniProtKB:P53566, ECO:0000269|PubMed:11242107, ECO:0000269|PubMed:14660596}.; FUNCTION: [Isoform 3]: Can act as dominant-negative. Binds DNA and have transctivation activity, even if much less efficiently than isoform 2. Does not inhibit cell proliferation (PubMed:14660596). {ECO:0000250|UniProtKB:P05554, ECO:0000250|UniProtKB:P53566, ECO:0000269|PubMed:14660596}.; FUNCTION: [Isoform 4]: Directly and specifically enhances ribosomal DNA transcription interacting with RNA polymerase I-specific cofactors and inducing histone acetylation. {ECO:0000269|PubMed:20075868}. |
| P67809 | YBX1 | S36 | ochoa | Y-box-binding protein 1 (YB-1) (CCAAT-binding transcription factor I subunit A) (CBF-A) (DNA-binding protein B) (DBPB) (Enhancer factor I subunit A) (EFI-A) (Nuclease-sensitive element-binding protein 1) (Y-box transcription factor) | DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing, DNA repair and transcription regulation (PubMed:10817758, PubMed:11698476, PubMed:14718551, PubMed:18809583, PubMed:31358969, PubMed:8188694). Predominantly acts as a RNA-binding protein: binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C) (PubMed:19561594, PubMed:31358969). Promotes mRNA stabilization: acts by binding to m5C-containing mRNAs and recruiting the mRNA stability maintainer ELAVL1, thereby preventing mRNA decay (PubMed:10817758, PubMed:11698476, PubMed:31358969). Component of the CRD-mediated complex that promotes MYC mRNA stability (PubMed:19029303). Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Plays a key role in RNA composition of extracellular exosomes by defining the sorting of small non-coding RNAs, such as tRNAs, Y RNAs, Vault RNAs and miRNAs (PubMed:27559612, PubMed:29073095). Probably sorts RNAs in exosomes by recognizing and binding C5-methylcytosine (m5C)-containing RNAs (PubMed:28341602, PubMed:29073095). Acts as a key effector of epidermal progenitors by preventing epidermal progenitor senescence: acts by regulating the translation of a senescence-associated subset of cytokine mRNAs, possibly by binding to m5C-containing mRNAs (PubMed:29712925). Also involved in pre-mRNA alternative splicing regulation: binds to splice sites in pre-mRNA and regulates splice site selection (PubMed:12604611). Binds to TSC22D1 transcripts, thereby inhibiting their translation and negatively regulating TGF-beta-mediated transcription of COL1A2 (By similarity). Also able to bind DNA: regulates transcription of the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7' (PubMed:18809583). Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes (PubMed:18809583, PubMed:8188694). Promotes separation of DNA strands that contain mismatches or are modified by cisplatin (PubMed:14718551). Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA, suggesting a role in DNA repair (PubMed:14718551). The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation (PubMed:19483673). {ECO:0000250|UniProtKB:P62960, ECO:0000250|UniProtKB:Q28618, ECO:0000269|PubMed:10817758, ECO:0000269|PubMed:11698476, ECO:0000269|PubMed:12604611, ECO:0000269|PubMed:14718551, ECO:0000269|PubMed:18809583, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:19483673, ECO:0000269|PubMed:19561594, ECO:0000269|PubMed:27559612, ECO:0000269|PubMed:28341602, ECO:0000269|PubMed:29073095, ECO:0000269|PubMed:29712925, ECO:0000269|PubMed:31358969, ECO:0000269|PubMed:8188694}. |
| P69891 | HBG1 | S53 | ochoa | Hemoglobin subunit gamma-1 (Gamma-1-globin) (Hb F Agamma) (Hemoglobin gamma-1 chain) (Hemoglobin gamma-A chain) | Gamma chains make up the fetal hemoglobin F, in combination with alpha chains. {ECO:0000269|PubMed:11514664, ECO:0000269|PubMed:22096240, ECO:0000269|PubMed:6198905}. |
| P69892 | HBG2 | S53 | ochoa | Hemoglobin subunit gamma-2 (Gamma-2-globin) (Hb F Ggamma) (Hemoglobin gamma-2 chain) (Hemoglobin gamma-G chain) | Gamma chains make up the fetal hemoglobin F, in combination with alpha chains. {ECO:0000269|PubMed:19065339, ECO:0000269|PubMed:21561349, ECO:0000269|PubMed:24502349}. |
| P78413 | IRX4 | S473 | ochoa | Iroquois-class homeodomain protein IRX-4 (Homeodomain protein IRXA3) (Iroquois homeobox protein 4) | Likely to be an important mediator of ventricular differentiation during cardiac development. |
| Q00341 | HDLBP | S756 | ochoa | Vigilin (High density lipoprotein-binding protein) (HDL-binding protein) | Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol. |
| Q01484 | ANK2 | S29 | ochoa | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}. |
| Q04637 | EIF4G1 | S1098 | ochoa | Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:29987188). Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) (PubMed:29987188). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon (PubMed:29987188). Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning (PubMed:29987188). As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). {ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29987188}. |
| Q09666 | AHNAK | S5604 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q13363 | CTBP1 | S100 | psp | C-terminal-binding protein 1 (CtBP1) (EC 1.1.1.-) | Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation. {ECO:0000269|PubMed:12419229, ECO:0000269|PubMed:15542832, ECO:0000269|PubMed:18212045, ECO:0000269|PubMed:19103759, ECO:0000269|PubMed:9858600}. |
| Q13586 | STIM1 | S567 | ochoa | Stromal interaction molecule 1 | Acts as a Ca(2+) sensor that gates two major inward rectifying Ca(2+) channels at the plasma membrane: Ca(2+) release-activated Ca(2+) (CRAC) channels and arachidonate-regulated Ca(2+)-selective (ARC) channels (PubMed:15866891, PubMed:16005298, PubMed:16208375, PubMed:16537481, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:18854159, PubMed:19182790, PubMed:19249086, PubMed:19622606, PubMed:19706554, PubMed:22464749, PubMed:24069340, PubMed:24351972, PubMed:24591628, PubMed:25326555, PubMed:26322679, PubMed:28219928, PubMed:32415068). Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates CRAC channel pore-forming subunits ORA1, ORA2 and ORAI3 to generate sustained and oscillatory Ca(2+) entry (PubMed:16208375, PubMed:16537481, PubMed:32415068). Involved in enamel formation (PubMed:24621671). {ECO:0000269|PubMed:15866891, ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16208375, ECO:0000269|PubMed:16537481, ECO:0000269|PubMed:16733527, ECO:0000269|PubMed:16766533, ECO:0000269|PubMed:16807233, ECO:0000269|PubMed:18854159, ECO:0000269|PubMed:19182790, ECO:0000269|PubMed:19249086, ECO:0000269|PubMed:19622606, ECO:0000269|PubMed:19706554, ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:24069340, ECO:0000269|PubMed:24351972, ECO:0000269|PubMed:24591628, ECO:0000269|PubMed:24621671, ECO:0000269|PubMed:25326555, ECO:0000269|PubMed:26322679, ECO:0000269|PubMed:28219928, ECO:0000269|PubMed:32415068}. |
| Q13627 | DYRK1A | S538 | ochoa | Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.11.23) (EC 2.7.12.1) (Dual specificity YAK1-related kinase) (HP86) (Protein kinase minibrain homolog) (MNBH) (hMNB) | Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities (PubMed:20981014, PubMed:21127067, PubMed:23665168, PubMed:30773093, PubMed:8769099). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3 (PubMed:23665168). Plays an important role in double-strand breaks (DSBs) repair following DNA damage (PubMed:31024071). Mechanistically, phosphorylates RNF169 and increases its ability to block accumulation of TP53BP1 at the DSB sites thereby promoting homologous recombination repair (HRR) (PubMed:30773093). Also acts as a positive regulator of transcription by acting as a CTD kinase that mediates phosphorylation of the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A (PubMed:25620562, PubMed:29849146). May play a role in a signaling pathway regulating nuclear functions of cell proliferation (PubMed:14500717). Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Has pro-survival function and negatively regulates the apoptotic process (By similarity). Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1 (By similarity). This in turn inhibits p53/TP53 activity and apoptosis (By similarity). Phosphorylates SEPTIN4, SEPTIN5 and SF3B1 at 'Thr-434' (By similarity). {ECO:0000250|UniProtKB:Q61214, ECO:0000250|UniProtKB:Q63470, ECO:0000269|PubMed:14500717, ECO:0000269|PubMed:20981014, ECO:0000269|PubMed:21127067, ECO:0000269|PubMed:23665168, ECO:0000269|PubMed:25620562, ECO:0000269|PubMed:29849146, ECO:0000269|PubMed:30773093, ECO:0000269|PubMed:31024071, ECO:0000269|PubMed:8769099}. |
| Q13796 | SHROOM2 | S847 | ochoa | Protein Shroom2 (Apical-like protein) (Protein APXL) | May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). {ECO:0000250}. |
| Q14689 | DIP2A | S94 | ochoa | Disco-interacting protein 2 homolog A (DIP2 homolog A) (EC 6.2.1.1) | Catalyzes the de novo synthesis of acetyl-CoA in vitro (By similarity). Promotes acetylation of CTTN, possibly by providing the acetyl donor, ensuring correct dendritic spine morphology and synaptic transmission (By similarity). Binds to follistatin-related protein FSTL1 and may act as a cell surface receptor for FSTL1, contributing to AKT activation and subsequent FSTL1-induced survival and function of endothelial cells and cardiac myocytes (PubMed:20054002). {ECO:0000250|UniProtKB:Q8BWT5, ECO:0000269|PubMed:20054002}. |
| Q14697 | GANAB | S591 | ochoa | Neutral alpha-glucosidase AB (EC 3.2.1.207) (Alpha-glucosidase 2) (Glucosidase II subunit alpha) | Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:10929008). Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia (PubMed:27259053). {ECO:0000269|PubMed:10929008, ECO:0000269|PubMed:27259053}. |
| Q15035 | TRAM2 | S346 | ochoa | Translocating chain-associated membrane protein 2 | Necessary for collagen type I synthesis. May couple the activity of the ER Ca(2+) pump SERCA2B with the activity of the translocon. This coupling may increase the local Ca(2+) concentration at the site of collagen synthesis, and a high Ca(2+) concentration may be necessary for the function of molecular chaperones involved in collagen folding. Required for proper insertion of the first transmembrane helix N-terminus of TM4SF20 into the ER lumen, may act as a ceramide sensor for regulated alternative translocation (RAT) (PubMed:27499293). {ECO:0000269|PubMed:14749390, ECO:0000269|PubMed:27499293}. |
| Q15722 | LTB4R | S320 | ochoa|psp | Leukotriene B4 receptor 1 (LTB4-R 1) (LTB4-R1) (Chemoattractant receptor-like 1) (G-protein coupled receptor 16) (P2Y purinoceptor 7) (P2Y7) | Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response. |
| Q27J81 | INF2 | S1204 | ochoa | Inverted formin-2 (HBEBP2-binding protein C) | Severs actin filaments and accelerates their polymerization and depolymerization. {ECO:0000250}. |
| Q2M1V0 | ISX | S183 | psp | Intestine-specific homeobox (RAX-like homeobox) | Transcription factor that regulates gene expression in intestine. May participate in vitamin A metabolism most likely by regulating BCO1 expression in the intestine (By similarity). {ECO:0000250}. |
| Q3MIP1 | ITPRIPL2 | S139 | ochoa | Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2 | None |
| Q4KMQ1 | TPRN | S222 | ochoa | Taperin | Essential for hearing (By similarity). Required for maintenance of stereocilia on both inner and outer hair cells (By similarity). Necessary for the integrity of the stereociliary rootlet (By similarity). May act as an actin cytoskeleton regulator involved in the regulation of actin dynamics at the pointed end in hair cells (By similarity). Forms rings at the base of stereocilia and binds actin filaments in the stereocilia which may stabilize the stereocilia (By similarity). Acts as a strong inhibitor of PPP1CA phosphatase activity (PubMed:23213405). Recruited to sites of DNA damage and may play a role in DNA damage repair (PubMed:23213405). {ECO:0000250|UniProtKB:A2AI08, ECO:0000269|PubMed:23213405}. |
| Q5TCZ1 | SH3PXD2A | S1016 | ochoa | SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains) | Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells (PubMed:27789576). Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. {ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:15710328, ECO:0000269|PubMed:15710903, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497, ECO:0000269|PubMed:27789576}. |
| Q5VWQ8 | DAB2IP | S827 | ochoa | Disabled homolog 2-interacting protein (DAB2 interaction protein) (DAB2-interacting protein) (ASK-interacting protein 1) (AIP-1) (DOC-2/DAB-2 interactive protein) | Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Involved in several processes such as innate immune response, inflammation and cell growth inhibition, apoptosis, cell survival, angiogenesis, cell migration and maturation. Also plays a role in cell cycle checkpoint control; reduces G1 phase cyclin levels resulting in G0/G1 cell cycle arrest. Mediates signal transduction by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF), interferon (IFN) or lipopolysaccharide (LPS). Modulates the balance between phosphatidylinositol 3-kinase (PI3K)-AKT-mediated cell survival and apoptosis stimulated kinase (MAP3K5)-JNK signaling pathways; sequesters both AKT1 and MAP3K5 and counterbalances the activity of each kinase by modulating their phosphorylation status in response to pro-inflammatory stimuli. Acts as a regulator of the endoplasmic reticulum (ER) unfolded protein response (UPR) pathway; specifically involved in transduction of the ER stress-response to the JNK cascade through ERN1. Mediates TNF-alpha-induced apoptosis activation by facilitating dissociation of inhibitor 14-3-3 from MAP3K5; recruits the PP2A phosphatase complex which dephosphorylates MAP3K5 on 'Ser-966', leading to the dissociation of 13-3-3 proteins and activation of the MAP3K5-JNK signaling pathway in endothelial cells. Also mediates TNF/TRAF2-induced MAP3K5-JNK activation, while it inhibits CHUK-NF-kappa-B signaling. Acts a negative regulator in the IFN-gamma-mediated JAK-STAT signaling cascade by inhibiting smooth muscle cell (VSMCs) proliferation and intimal expansion, and thus, prevents graft arteriosclerosis (GA). Acts as a GTPase-activating protein (GAP) for the ADP ribosylation factor 6 (ARF6), Ras and RAB40C (PubMed:29156729). Promotes hydrolysis of the ARF6-bound GTP and thus, negatively regulates phosphatidylinositol 4,5-bisphosphate (PIP2)-dependent TLR4-TIRAP-MyD88 and NF-kappa-B signaling pathways in endothelial cells in response to lipopolysaccharides (LPS). Binds specifically to phosphatidylinositol 4-phosphate (PtdIns4P) and phosphatidylinositol 3-phosphate (PtdIns3P). In response to vascular endothelial growth factor (VEGFA), acts as a negative regulator of the VEGFR2-PI3K-mediated angiogenic signaling pathway by inhibiting endothelial cell migration and tube formation. In the developing brain, promotes both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex in a glial-dependent locomotion process. Probable downstream effector of the Reelin signaling pathway; promotes Purkinje cell (PC) dendrites development and formation of cerebellar synapses. Also functions as a tumor suppressor protein in prostate cancer progression; prevents cell proliferation and epithelial-to-mesenchymal transition (EMT) through activation of the glycogen synthase kinase-3 beta (GSK3B)-induced beta-catenin and inhibition of PI3K-AKT and Ras-MAPK survival downstream signaling cascades, respectively. {ECO:0000269|PubMed:12813029, ECO:0000269|PubMed:17389591, ECO:0000269|PubMed:18292600, ECO:0000269|PubMed:19033661, ECO:0000269|PubMed:19903888, ECO:0000269|PubMed:19948740, ECO:0000269|PubMed:20080667, ECO:0000269|PubMed:20154697, ECO:0000269|PubMed:21700930, ECO:0000269|PubMed:22696229, ECO:0000269|PubMed:29156729}. |
| Q641Q2 | WASHC2A | S1001 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
| Q684P5 | RAP1GAP2 | S574 | ochoa | Rap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activating Rap/Ran-GAP domain-like protein 4) | GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. {ECO:0000269|PubMed:15632203}. |
| Q68DC2 | ANKS6 | S660 | ochoa | Ankyrin repeat and SAM domain-containing protein 6 (Ankyrin repeat domain-containing protein 14) (SamCystin) (Sterile alpha motif domain-containing protein 6) (SAM domain-containing protein 6) | Required for renal function. {ECO:0000269|PubMed:23793029}. |
| Q6P3S6 | FBXO42 | S545 | ochoa | F-box only protein 42 (Just one F-box and Kelch domain-containing protein) | Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation. {ECO:0000269|PubMed:19509332}. |
| Q6SPF0 | SAMD1 | S399 | ochoa | Sterile alpha motif domain-containing protein 1 (SAM domain-containing protein 1) (Atherin) | Unmethylated CpG islands (CGIs)-binding protein which localizes to H3K4me3-decorated CGIs, where it acts as a transcriptional repressor (PubMed:33980486). Tethers L3MBTL3 to chromatin and interacts with the KDM1A histone demethylase complex to modulate H3K4me2 and H3K4me3 levels at CGIs (PubMed:33980486). Plays a role in atherogenesis by binding with LDL on cell surface and promoting LDL oxidation which leads to the formation of foam cell (PubMed:16159594, PubMed:34006929). {ECO:0000269|PubMed:16159594, ECO:0000269|PubMed:33980486, ECO:0000269|PubMed:34006929}. |
| Q717R9 | CYS1 | S128 | ochoa | Cystin-1 (Cilia-associated protein) | None |
| Q7KZF4 | SND1 | S238 | ochoa | Staphylococcal nuclease domain-containing protein 1 (EC 3.1.31.1) (100 kDa coactivator) (EBNA2 coactivator p100) (Tudor domain-containing protein 11) (p100 co-activator) | Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs (PubMed:18453631, PubMed:28546213). As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition (PubMed:28546213). Functions as a bridging factor between STAT6 and the basal transcription factor (PubMed:12234934). Plays a role in PIM1 regulation of MYB activity (PubMed:9809063). Functions as a transcriptional coactivator for STAT5 (By similarity). {ECO:0000250|UniProtKB:Q78PY7, ECO:0000269|PubMed:12234934, ECO:0000269|PubMed:18453631, ECO:0000269|PubMed:28546213, ECO:0000269|PubMed:9809063}.; FUNCTION: (Microbial infection) Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2 (EBNA2). {ECO:0000269|PubMed:7651391}.; FUNCTION: (Microbial infection) Promotes SARS-CoV-2 RNA synthesis by binding to negative-sense RNA and the viral protein nsp9. {ECO:0000269|PubMed:37794589}. |
| Q7Z3G6 | PRICKLE2 | S319 | ochoa | Prickle-like protein 2 | None |
| Q7Z460 | CLASP1 | S280 | ochoa | CLIP-associating protein 1 (Cytoplasmic linker-associated protein 1) (Multiple asters homolog 1) (Protein Orbit homolog 1) (hOrbit1) | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:12837247, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864}. |
| Q7Z460 | CLASP1 | S797 | ochoa | CLIP-associating protein 1 (Cytoplasmic linker-associated protein 1) (Multiple asters homolog 1) (Protein Orbit homolog 1) (hOrbit1) | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:12837247, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864}. |
| Q7Z4H7 | HAUS6 | S447 | ochoa | HAUS augmin-like complex subunit 6 | Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Promotes the nucleation of microtubules from the spindle through recruitment of NEDD1 and gamma-tubulin. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}. |
| Q7Z6I6 | ARHGAP30 | S994 | ochoa | Rho GTPase-activating protein 30 (Rho-type GTPase-activating protein 30) | GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. {ECO:0000269|PubMed:21565175}. |
| Q86VR2 | RETREG3 | S28 | ochoa | Reticulophagy regulator 3 | Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress (PubMed:34338405). When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins (PubMed:34338405). Promotes ER membrane curvature and ER tubulation required for subsequent ER fragmentation and engulfment into autophagosomes (PubMed:33826365). Required for collagen quality control in a LIR motif-dependent manner (By similarity). Mediates NRF1-enhanced neurite outgrowth (PubMed:26040720). {ECO:0000250|UniProtKB:Q9CQV4, ECO:0000269|PubMed:26040720, ECO:0000269|PubMed:33826365, ECO:0000269|PubMed:34338405}. |
| Q8IVD9 | NUDCD3 | S146 | ochoa | NudC domain-containing protein 3 | None |
| Q8IVT2 | MISP | S397 | ochoa|psp | Mitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein) | Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus. {ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:23574715}. |
| Q8N1G1 | REXO1 | S459 | ochoa | RNA exonuclease 1 homolog (EC 3.1.-.-) (Elongin-A-binding protein 1) (EloA-BP1) (Transcription elongation factor B polypeptide 3-binding protein 1) | Seems to have no detectable effect on transcription elongation in vitro. {ECO:0000269|PubMed:12943681}. |
| Q8N5C8 | TAB3 | S103 | ochoa | TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 3) (NF-kappa-B-activating protein 1) (TAK1-binding protein 3) (TAB-3) (TGF-beta-activated kinase 1-binding protein 3) | Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158122). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158122, PubMed:36593296). The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (PubMed:15327770, PubMed:18079694, PubMed:22158122). {ECO:0000269|PubMed:14633987, ECO:0000269|PubMed:14766965, ECO:0000269|PubMed:15327770, ECO:0000269|PubMed:18079694, ECO:0000269|PubMed:22158122, ECO:0000269|PubMed:36593296}.; FUNCTION: [Isoform 2]: May be an oncogenic factor. {ECO:0000269|PubMed:14766965}. |
| Q8N8K9 | KIAA1958 | S249 | ochoa | Uncharacterized protein KIAA1958 | None |
| Q8NDF8 | TENT4B | S484 | ochoa | Terminal nucleotidyltransferase 4B (Non-canonical poly(A) RNA polymerase PAPD5) (EC 2.7.7.19) (PAP-associated domain-containing protein 5) (Terminal guanylyltransferase) (EC 2.7.7.-) (Terminal uridylyltransferase 3) (TUTase 3) (Topoisomerase-related function protein 4-2) (TRF4-2) | Terminal nucleotidyltransferase that catalyzes preferentially the transfer of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation (PubMed:21788334, PubMed:30026317). Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Doesn't need a cofactor for polyadenylation activity (in vitro) (PubMed:21788334, PubMed:21855801). Required for cytoplasmic polyadenylation of mRNAs involved in carbohydrate metabolism, including the glucose transporter SLC2A1/GLUT1 (PubMed:28383716). Plays a role in replication-dependent histone mRNA degradation, probably through terminal uridylation of mature histone mRNAs. May play a role in sister chromatid cohesion (PubMed:18172165). Mediates 3' adenylation of the microRNA MIR21 followed by its 3'-to-5' trimming by the exoribonuclease PARN leading to degradation (PubMed:25049417). Mediates 3' adenylation of H/ACA box snoRNAs (small nucleolar RNAs) followed by its 3'-to-5' trimming by the exoribonuclease PARN which enhances snoRNA stability and maturation (PubMed:22442037). {ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:21788334, ECO:0000269|PubMed:21855801, ECO:0000269|PubMed:22442037, ECO:0000269|PubMed:25049417, ECO:0000269|PubMed:28383716, ECO:0000269|PubMed:30026317}. |
| Q8TAA3 | PSMA8 | S158 | ochoa | Proteasome subunit alpha-type 8 (Proteasome alpha 4 subunit) (Alpha4s) (Proteasome subunit alpha-type 7-like) | Component of the spermatoproteasome, a proteasome specifically found in testis that promotes acetylation-dependent degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. The proteasome is a protein complex that degrades unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Required for 20S core proteasome assembly, essential for the degradation of meiotic proteins RAD51 and RPA1 at late prophase I and the progression of meiosis I during spermatogenesis. Localizes to the synaptonemal complex, a 'zipper'-like structure that holds homologous chromosome pairs in synapsis during meiotic prophase I. {ECO:0000250|UniProtKB:Q9CWH6}. |
| Q8TBN0 | RAB3IL1 | S197 | ochoa | Guanine nucleotide exchange factor for Rab-3A (Rab-3A-interacting-like protein 1) (Rab3A-interacting-like protein 1) (Rabin3-like 1) | Guanine nucleotide exchange factor (GEF) which may activate RAB3A, a GTPase that regulates synaptic vesicle exocytosis. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May also activate RAB8A and RAB8B. {ECO:0000269|PubMed:20937701}. |
| Q8TF44 | C2CD4C | S178 | ochoa | C2 calcium-dependent domain-containing protein 4C (Nuclear-localized factor 3) (Protein FAM148C) | None |
| Q8WXE1 | ATRIP | S518 | ochoa | ATR-interacting protein (ATM and Rad3-related-interacting protein) | Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein. {ECO:0000269|PubMed:12791985}. |
| Q8WZ75 | ROBO4 | S899 | ochoa | Roundabout homolog 4 (Magic roundabout) | Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity). Involved in the maintenance of endothelial barrier organization and function (PubMed:30455415). {ECO:0000250, ECO:0000269|PubMed:30455415}. |
| Q92804 | TAF15 | S289 | ochoa | TATA-binding protein-associated factor 2N (68 kDa TATA-binding protein-associated factor) (TAF(II)68) (TAFII68) (RNA-binding protein 56) | RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Can enter the preinitiation complex together with the RNA polymerase II (Pol II). {ECO:0000269|PubMed:19124016, ECO:0000269|PubMed:21256132}. |
| Q92997 | DVL3 | S280 | psp | Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) | Involved in the signal transduction pathway mediated by multiple Wnt genes. {ECO:0000250|UniProtKB:Q61062}. |
| Q93084 | ATP2A3 | S362 | ochoa | Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (SERCA3) (SR Ca(2+)-ATPase 3) (EC 7.2.2.10) (Calcium pump 3) | This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction. {ECO:0000269|PubMed:11956212, ECO:0000269|PubMed:15028735}. |
| Q969Y2 | GTPBP3 | S24 | ochoa | 5-taurinomethyluridine-[tRNA] synthase subunit GTPB3, mitochondrial (EC 3.6.1.-) (GTP-binding protein 3) (Mitochondrial GTP-binding protein 1) (tRNA modification GTPase GTPBP3, mitochondrial) | GTPase component of the GTPBP3-MTO1 complex that catalyzes the 5-taurinomethyluridine (taum(5)U) modification at the 34th wobble position (U34) of mitochondrial tRNAs (mt-tRNAs), which plays a role in mt-tRNA decoding and mitochondrial translation (PubMed:29390138, PubMed:33619562). Taum(5)U formation on mammalian mt-tRNA requires the presence of both GTPBP3-mediated GTPase activity and MTO1 catalytic activity (PubMed:29390138). {ECO:0000269|PubMed:29390138, ECO:0000269|PubMed:33619562}. |
| Q96HB5 | CCDC120 | S331 | ochoa | Coiled-coil domain-containing protein 120 | Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells (PubMed:28422092). Together with CCDC68, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly (PubMed:28422092). Recruits NIN and CEP170 to centrosomes (PubMed:28422092). Also required for neurite growth. Localizes CYTH2 to vesicles to allow its transport along neurites, and subsequent ARF6 activation and neurite growth. {ECO:0000269|PubMed:25326380}. |
| Q96PE2 | ARHGEF17 | S717 | ochoa | Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}. |
| Q96PY6 | NEK1 | S428 | ochoa | Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) (Renal carcinoma antigen NY-REN-55) | Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity (PubMed:20230784). Involved in DNA damage checkpoint control and for proper DNA damage repair (PubMed:20230784). In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death (PubMed:20230784). May be implicated in the control of meiosis (By similarity). Involved in cilium assembly (PubMed:21211617). {ECO:0000250|UniProtKB:P51954, ECO:0000269|PubMed:20230784, ECO:0000269|PubMed:21211617}. |
| Q96RL1 | UIMC1 | S236 | ochoa | BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Retinoid X receptor-interacting protein 110) (Ubiquitin interaction motif-containing protein 1) | Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.38). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. {ECO:0000269|PubMed:12080054, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:17525342, ECO:0000269|PubMed:17621610, ECO:0000269|PubMed:17643121, ECO:0000269|PubMed:19015238, ECO:0000269|PubMed:19202061, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19328070, ECO:0000269|PubMed:24627472, ECO:0000269|Ref.38}. |
| Q96T58 | SPEN | S1076 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q99081 | TCF12 | S332 | ochoa | Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) | Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250|UniProtKB:Q61286, ECO:0000269|PubMed:32620954}. |
| Q99496 | RNF2 | S203 | ochoa | E3 ubiquitin-protein ligase RING2 (EC 2.3.2.27) (Huntingtin-interacting protein 2-interacting protein 3) (HIP2-interacting protein 3) (Protein DinG) (RING finger protein 1B) (RING1b) (RING finger protein 2) (RING finger protein BAP-1) (RING-type E3 ubiquitin transferase RING2) | E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation (PubMed:15386022, PubMed:16359901, PubMed:21772249, PubMed:25355358, PubMed:25519132, PubMed:26151332, PubMed:33864376). H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation (By similarity). Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:16359901, PubMed:26151332). PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility (PubMed:26151332). E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4 (PubMed:21772249). Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity (Probable). Association with the chromosomal DNA is cell-cycle dependent. In resting B- and T-lymphocytes, interaction with AURKB leads to block its activity, thereby maintaining transcription in resting lymphocytes (By similarity). Also acts as a negative regulator of autophagy by mediating ubiquitination of AMBRA1, leading to its subsequent degradation (By similarity). {ECO:0000250|UniProtKB:Q9CQJ4, ECO:0000269|PubMed:11513855, ECO:0000269|PubMed:15386022, ECO:0000269|PubMed:16359901, ECO:0000269|PubMed:16714294, ECO:0000269|PubMed:20696397, ECO:0000269|PubMed:21772249, ECO:0000269|PubMed:25355358, ECO:0000269|PubMed:25519132, ECO:0000269|PubMed:26151332, ECO:0000269|PubMed:33864376, ECO:0000305}. |
| Q9BT23 | LIMD2 | S29 | ochoa | LIM domain-containing protein 2 | Acts as an activator of the protein-kinase ILK, thereby regulating cell motility (PubMed:24590809). {ECO:0000269|PubMed:24590809}. |
| Q9BU76 | MMTAG2 | S127 | ochoa | Multiple myeloma tumor-associated protein 2 (hMMTAG2) | None |
| Q9BU76 | MMTAG2 | S155 | ochoa | Multiple myeloma tumor-associated protein 2 (hMMTAG2) | None |
| Q9BY89 | KIAA1671 | S1379 | ochoa | Uncharacterized protein KIAA1671 | None |
| Q9C0C2 | TNKS1BP1 | S1452 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9C0H5 | ARHGAP39 | S248 | ochoa | Rho GTPase-activating protein 39 | None |
| Q9H1Z4 | WDR13 | S116 | ochoa | WD repeat-containing protein 13 | None |
| Q9H4G0 | EPB41L1 | S396 | ochoa | Band 4.1-like protein 1 (Erythrocyte membrane protein band 4.1-like 1) (Neuronal protein 4.1) (4.1N) | May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases. |
| Q9H8Y5 | ANKZF1 | S533 | ochoa | tRNA endonuclease ANKZF1 (EC 3.1.-.-) (Ankyrin repeat and zinc finger domain-containing protein 1) (Zinc finger protein 744) | Endonuclease that cleaves polypeptidyl-tRNAs downstream of the ribosome-associated quality control (RQC) pathway to release incompletely synthesized polypeptides for degradation (PubMed:29632312, PubMed:30244831, PubMed:31011209). The RQC pathway disassembles aberrantly stalled translation complexes to recycle or degrade the constituent parts (PubMed:29632312, PubMed:30244831, PubMed:31011209). ANKZF1 acts downstream disassembly of stalled ribosomes and specifically cleaves off the terminal 3'-CCA nucleotides universal to all tRNAs from polypeptidyl-tRNAs, releasing (1) ubiquitinated polypeptides from 60S ribosomal subunit for degradation and (2) cleaved tRNAs (PubMed:31011209). ANKZF1-cleaved tRNAs are then repaired and recycled by ELAC1 and TRNT1 (PubMed:31011209, PubMed:32075755). Also plays a role in the cellular response to hydrogen peroxide and in the maintenance of mitochondrial integrity under conditions of cellular stress (PubMed:28302725). {ECO:0000269|PubMed:28302725, ECO:0000269|PubMed:29632312, ECO:0000269|PubMed:30244831, ECO:0000269|PubMed:31011209, ECO:0000269|PubMed:32075755}. |
| Q9H910 | JPT2 | S125 | ochoa | Jupiter microtubule associated homolog 2 (Hematological and neurological expressed 1-like protein) (HN1-like protein) | Nicotinic acid adenine dinucleotide phosphate (NAADP) binding protein required for NAADP-evoked intracellular calcium release (PubMed:33758061, PubMed:33758062). Confers NAADP-sensitivity to the two pore channels (TPCs) complex (PubMed:33758061). Enables NAADP to activate Ca(2+) release from the endoplasmic reticulum through ryanodine receptors (PubMed:33758062). {ECO:0000269|PubMed:33758061, ECO:0000269|PubMed:33758062}.; FUNCTION: (Microbial infection) Involved in the endolysosomal trafficking of human coronavirus SARS-CoV-2. {ECO:0000269|PubMed:33758061}. |
| Q9HC44 | GPBP1L1 | S50 | ochoa | Vasculin-like protein 1 (GC-rich promoter-binding protein 1-like 1) | Possible transcription factor. {ECO:0000305}. |
| Q9HCE6 | ARHGEF10L | S1256 | ochoa | Rho guanine nucleotide exchange factor 10-like protein (GrinchGEF) | Acts as a guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC. {ECO:0000269|PubMed:16112081}. |
| Q9NQT8 | KIF13B | S1797 | ochoa | Kinesin-like protein KIF13B (Kinesin-like protein GAKIN) | Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes. {ECO:0000269|PubMed:20194617}. |
| Q9NUQ8 | ABCF3 | S79 | ochoa | ATP-binding cassette sub-family F member 3 | Displays an antiviral effect against flaviviruses such as west Nile virus (WNV) in the presence of OAS1B. {ECO:0000250}. |
| Q9NV58 | RNF19A | S518 | ochoa | E3 ubiquitin-protein ligase RNF19A (EC 2.3.2.31) (Double ring-finger protein) (Dorfin) (RING finger protein 19A) (p38) | E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection. {ECO:0000269|PubMed:11237715, ECO:0000269|PubMed:12145308, ECO:0000269|PubMed:12750386, ECO:0000269|PubMed:15456787, ECO:0000269|PubMed:16513638}. |
| Q9NV70 | EXOC1 | S298 | ochoa | Exocyst complex component 1 (Exocyst complex component Sec3) | Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.; FUNCTION: (Microbial infection) Has an antiviral effect against flaviviruses by affecting viral RNA transcription and translation through the sequestration of elongation factor 1-alpha (EEF1A1). This results in decreased viral RNA synthesis and decreased viral protein translation. {ECO:0000269|PubMed:19889084}. |
| Q9NVT9 | ARMC1 | S189 | ochoa | Armadillo repeat-containing protein 1 | In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility. {ECO:0000269|PubMed:31644573}. |
| Q9NWW5 | CLN6 | S31 | ochoa | Ceroid-lipofuscinosis neuronal protein 6 (Protein CLN6) | None |
| Q9NXR1 | NDE1 | S239 | ochoa | Nuclear distribution protein nudE homolog 1 (NudE) | Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a postmitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex. Acts as a RAB9A/B effector that tethers RAB9-associated late endosomes to the dynein motor for their retrograde transport to the trans-Golgi network (PubMed:34793709). {ECO:0000269|PubMed:17600710, ECO:0000269|PubMed:21529752, ECO:0000269|PubMed:34793709}. |
| Q9P206 | NHSL3 | S215 | ochoa | NHS-like protein 3 | Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269|PubMed:32854746}. |
| Q9P244 | LRFN1 | S584 | ochoa | Leucine-rich repeat and fibronectin type III domain-containing protein 1 (Synaptic adhesion-like molecule 2) | Promotes neurite outgrowth in hippocampal neurons. Involved in the regulation and maintenance of excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1 (By similarity). {ECO:0000250}. |
| Q9P265 | DIP2B | S100 | ochoa | Disco-interacting protein 2 homolog B (DIP2 homolog B) | Negatively regulates axonal outgrowth and is essential for normal synaptic transmission. Not required for regulation of axon polarity. Promotes acetylation of alpha-tubulin. {ECO:0000250|UniProtKB:Q3UH60}. |
| Q9UGP4 | LIMD1 | S145 | ochoa | LIM domain-containing protein 1 | Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation. {ECO:0000269|PubMed:15542589, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22286099}. |
| Q9UGU0 | TCF20 | S1482 | ochoa | Transcription factor 20 (TCF-20) (Nuclear factor SPBP) (Protein AR1) (Stromelysin-1 PDGF-responsive element-binding protein) (SPRE-binding protein) | Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator. {ECO:0000269|PubMed:10995766}. |
| Q9UKG1 | APPL1 | S430 | psp | DCC-interacting protein 13-alpha (Dip13-alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1) | Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism (PubMed:10490823, PubMed:15016378, PubMed:19661063, PubMed:26073777, PubMed:26583432). Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex (PubMed:15016378). Functions as a positive regulator of innate immune response via activation of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1 (By similarity). Inhibits Fc-gamma receptor-mediated phagocytosis through PI3K/Akt signaling in macrophages (By similarity). Regulates TLR4 signaling in activated macrophages (By similarity). Involved in trafficking of the TGFBR1 from the endosomes to the nucleus via microtubules in a TRAF6-dependent manner (PubMed:26583432). Plays a role in cell metabolism by regulating adiponecting and insulin signaling pathways (PubMed:19661063, PubMed:24879834, PubMed:26073777). Required for fibroblast migration through HGF cell signaling (By similarity). Positive regulator of beta-catenin/TCF-dependent transcription through direct interaction with RUVBL2/reptin resulting in the relief of RUVBL2-mediated repression of beta-catenin/TCF target genes by modulating the interactions within the beta-catenin-reptin-HDAC complex (PubMed:19433865). {ECO:0000250|UniProtKB:Q8K3H0, ECO:0000269|PubMed:10490823, ECO:0000269|PubMed:15016378, ECO:0000269|PubMed:19433865, ECO:0000269|PubMed:19661063, ECO:0000269|PubMed:24879834, ECO:0000269|PubMed:26073777, ECO:0000269|PubMed:26583432}. |
| Q9UKZ4 | TENM1 | S105 | ochoa | Teneurin-1 (Ten-1) (Protein Odd Oz/ten-m homolog 1) (Tenascin-M1) (Ten-m1) (Teneurin transmembrane protein 1) [Cleaved into: Ten-1 intracellular domain (IDten-1) (Ten-1 ICD); Teneurin C-terminal-associated peptide (TCPA-1) (Ten-1 extracellular domain) (Ten-1 ECD)] | Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May function as a cellular signal transducer (By similarity). {ECO:0000250}.; FUNCTION: [Teneurin C-terminal-associated peptide]: Plays a role in the regulation of neuroplasticity in the limbic system. Mediates a rapid reorganization of actin- and tubulin-based cytoskeleton elements with an increase in dendritic arborization and spine density formation of neurons in the hippocampus and amygdala. Induces BDNF transcription inhibition in neurons. Activates the mitogen-activated protein (MAP) kinase 2 (MEK2) and extracellular signal-regulated kinase (ERK) cascade. Also acts as a bioactive neuroprotective peptide on limbic neurons of the brain and regulates stress-induced behavior: attenuates alkalosis-associated necrotic cell death and the effects of corticotropin-releasing factor (CRF) on c-fos/FOS induction and on the reinstatement of cocaine seeking (By similarity). {ECO:0000250}.; FUNCTION: [Ten-1 intracellular domain]: Induces gene transcription activation. {ECO:0000250}. |
| Q9ULI0 | ATAD2B | S61 | ochoa | ATPase family AAA domain-containing protein 2B | None |
| Q9ULL8 | SHROOM4 | S729 | ochoa | Protein Shroom4 (Second homolog of apical protein) | Probable regulator of cytoskeletal architecture that plays an important role in development. May regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II (By similarity). {ECO:0000250, ECO:0000269|PubMed:16684770}. |
| Q9UPN3 | MACF1 | S7322 | psp | Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) | [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250|UniProtKB:Q9QXZ0, ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:27693509}. |
| Q9UPP1 | PHF8 | S904 | ochoa | Histone lysine demethylase PHF8 (EC 1.14.11.27) (EC 1.14.11.65) (PHD finger protein 8) ([histone H3]-dimethyl-L-lysine(36) demethylase PHF8) ([histone H3]-dimethyl-L-lysine(9) demethylase PHF8) | Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Required for brain development, probably by regulating expression of neuron-specific genes. Only has activity toward H4K20Me1 when nucleosome is used as a substrate and when not histone octamer is used as substrate. May also have weak activity toward dimethylated H3 'Lys-36' (H3K36Me2), however, the relevance of this result remains unsure in vivo. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: has weak activity toward H3K9Me2 in absence of H3K4me3, while it has high activity toward H3K9me2 when binding H3K4me3. Positively modulates transcription of histone demethylase KDM5C, acting synergistically with transcription factor ARX; synergy may be related to enrichment of histone H3K4me3 in regulatory elements. {ECO:0000269|PubMed:19843542, ECO:0000269|PubMed:20023638, ECO:0000269|PubMed:20101266, ECO:0000269|PubMed:20208542, ECO:0000269|PubMed:20346720, ECO:0000269|PubMed:20421419, ECO:0000269|PubMed:20531378, ECO:0000269|PubMed:20548336, ECO:0000269|PubMed:20622853, ECO:0000269|PubMed:20622854, ECO:0000269|PubMed:31691806}. |
| Q9UPV7 | PHF24 | S51 | ochoa | PHD finger protein 24 | None |
| Q9UQB3 | CTNND2 | S285 | ochoa | Catenin delta-2 (Delta-catenin) (GT24) (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin) | Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses (PubMed:25807484). Involved in the regulation of Wnt signaling (PubMed:25807484). It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation (By similarity). Functions as a transcriptional activator when bound to ZBTB33 (By similarity). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. {ECO:0000250|UniProtKB:O35927, ECO:0000269|PubMed:25807484, ECO:0000269|PubMed:9971746}. |
| Q9Y2E4 | DIP2C | S89 | ochoa | Disco-interacting protein 2 homolog C (DIP2 homolog C) | None |
| Q9Y2J2 | EPB41L3 | S409 | ochoa | Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (Erythrocyte membrane protein band 4.1-like 3) [Cleaved into: Band 4.1-like protein 3, N-terminally processed] | Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5. {ECO:0000269|PubMed:15334060, ECO:0000269|PubMed:15737618, ECO:0000269|PubMed:16420693, ECO:0000269|PubMed:9892180}. |
| Q9Y2K9 | STXBP5L | S763 | psp | Syntaxin-binding protein 5-like (Lethal(2) giant larvae protein homolog 4) (Tomosyn-2) | Plays a role in vesicle trafficking and exocytosis inhibition. In pancreatic beta-cells, inhibits insulin secretion probably by interacting with and regulating STX1A and STX4, key t-SNARE proteins involved in the fusion of insulin granules to the plasma membrane. Also plays a role in neurotransmitter release by inhibiting basal acetylcholine release from axon terminals and by preventing synaptic fatigue upon repetitive stimulation (By similarity). Promotes as well axonal outgrowth (PubMed:25504045). {ECO:0000250|UniProtKB:Q5DQR4, ECO:0000269|PubMed:25504045}. |
| Q9Y446 | PKP3 | S260 | ochoa | Plakophilin-3 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:24124604). Required for the localization of DSG2, DSP and PKP2 to mature desmosome junctions (PubMed:20859650). May also play a role in the maintenance of DSG3 protein abundance in keratinocytes (By similarity). Required for the formation of DSP-containing desmosome precursors in the cytoplasm during desmosome assembly (PubMed:25208567). Also regulates the accumulation of CDH1 to mature desmosome junctions, via cAMP-dependent signaling and its interaction with activated RAP1A (PubMed:25208567). Positively regulates the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with FXR1, may also regulate the protein abundance of DSP via the same mechanism (PubMed:25225333). May also regulate the protein abundance of the desmosome component PKP1 (By similarity). Required for the organization of desmosome junctions at intercellular borders between basal keratinocytes of the epidermis, as a result plays a role in maintenance of the dermal barrier and regulation of the dermal inflammatory response (By similarity). Required during epidermal keratinocyte differentiation for cell adherence at tricellular cell-cell contacts, via regulation of the timely formation of adherens junctions and desmosomes in a calcium-dependent manner, and may also play a role in the organization of the intracellular actin fiber belt (By similarity). Acts as a negative regulator of the inflammatory response in hematopoietic cells of the skin and intestine, via modulation of proinflammatory cytokine production (By similarity). Important for epithelial barrier maintenance in the intestine to reduce intestinal permeability, thereby plays a role in protection from intestinal-derived endotoxemia (By similarity). Required for the development of hair follicles, via a role in the regulation of inner root sheaf length, correct alignment and anterior-posterior polarity of hair follicles (By similarity). Promotes proliferation and cell-cycle G1/S phase transition of keratinocytes (By similarity). Promotes E2F1-driven transcription of G1/S phase promoting genes by acting to release E2F1 from its inhibitory interaction with RB1, via sequestering RB1 and CDKN1A to the cytoplasm and thereby increasing CDK4- and CDK6-driven phosphorylation of RB1 (By similarity). May act as a scaffold protein to facilitate MAPK phosphorylation of RPS6KA protein family members and subsequently promote downstream EGFR signaling (By similarity). May play a role in the positive regulation of transcription of Wnt-mediated TCF-responsive target genes (PubMed:34058472). {ECO:0000250|UniProtKB:Q9QY23, ECO:0000269|PubMed:20859650, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:34058472}. |
| Q9Y4E5 | ZNF451 | S825 | ochoa | E3 SUMO-protein ligase ZNF451 (EC 2.3.2.-) (Coactivator for steroid receptors) (E3 SUMO-protein transferase ZNF451) (Zinc finger protein 451) | E3 SUMO-protein ligase; has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins (PubMed:26524493, PubMed:26524494). Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro). Required for MCM4 sumoylation (By similarity). Has no activity with SUMO1 (PubMed:26524493). Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site 'Lys-11' (PubMed:26524493). Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at 'Lys-9' (PubMed:24324267). Plays a role in regulating the transcription of AR targets (PubMed:18656483). {ECO:0000250|UniProtKB:Q8C0P7, ECO:0000269|PubMed:18656483, ECO:0000269|PubMed:24324267, ECO:0000269|PubMed:26524493, ECO:0000269|PubMed:26524494}. |
| Q9Y4F5 | CEP170B | S619 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
| P60174 | TPI1 | S212 | Sugiyama | Triosephosphate isomerase (TIM) (EC 5.3.1.1) (Methylglyoxal synthase) (EC 4.2.3.3) (Triose-phosphate isomerase) | Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. {ECO:0000269|PubMed:18562316}.; FUNCTION: It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids. {ECO:0000250|UniProtKB:P00939}. |
| P07602 | PSAP | S29 | Sugiyama | Prosaposin (Proactivator polypeptide) [Cleaved into: Saposin-A (Protein A); Saposin-B-Val; Saposin-B (Cerebroside sulfate activator) (CSAct) (Dispersin) (Sphingolipid activator protein 1) (SAP-1) (Sulfatide/GM1 activator); Saposin-C (A1 activator) (Co-beta-glucosidase) (Glucosylceramidase activator) (Sphingolipid activator protein 2) (SAP-2); Saposin-D (Component C) (Protein C)] | Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate.; FUNCTION: Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta-galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha-galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases.; FUNCTION: Saposin-D is a specific sphingomyelin phosphodiesterase activator (EC 3.1.4.12).; FUNCTION: [Prosaposin]: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. {ECO:0000250|UniProtKB:Q61207, ECO:0000269|PubMed:10383054}.; FUNCTION: Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases. |
| P62979 | RPS27A | S123 | Sugiyama | Ubiquitin-ribosomal protein eS31 fusion protein (Ubiquitin carboxyl extension protein 80) [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31 (40S ribosomal protein S27a)] | [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000303|PubMed:19754430}.; FUNCTION: [Small ribosomal subunit protein eS31]: Component of the 40S subunit of the ribosome (PubMed:23636399, PubMed:9582194). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:23636399, PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797, ECO:0000305|PubMed:9582194}. |
| Q9Y5X1 | SNX9 | S122 | Sugiyama | Sorting nexin-9 (SH3 and PX domain-containing protein 1) (Protein SDP1) (SH3 and PX domain-containing protein 3A) | Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate. {ECO:0000269|PubMed:11799118, ECO:0000269|PubMed:12952949, ECO:0000269|PubMed:15703209, ECO:0000269|PubMed:17609109, ECO:0000269|PubMed:17948057, ECO:0000269|PubMed:18388313, ECO:0000269|PubMed:20427313, ECO:0000269|PubMed:21048941, ECO:0000269|PubMed:22718350}. |
| O43353 | RIPK2 | S25 | Sugiyama | Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containing IL-1 beta ICE-kinase) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (Tyrosine-protein kinase RIPK2) (EC 2.7.10.2) | Serine/threonine/tyrosine-protein kinase that plays an essential role in modulation of innate and adaptive immune responses (PubMed:14638696, PubMed:17054981, PubMed:21123652, PubMed:28656966, PubMed:9575181, PubMed:9642260). Acts as a key effector of NOD1 and NOD2 signaling pathways: upon activation by bacterial peptidoglycans, NOD1 and NOD2 oligomerize and recruit RIPK2 via CARD-CARD domains, leading to the formation of RIPK2 filaments (PubMed:17054981, PubMed:17562858, PubMed:21123652, PubMed:22607974, PubMed:28656966, PubMed:29452636, PubMed:30026309). Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3, as well as 'Met-1'-linked (linear) polyubiquitination by the LUBAC complex, becoming a scaffolding protein for downstream effectors (PubMed:22607974, PubMed:28545134, PubMed:29452636, PubMed:30026309, PubMed:30279485, PubMed:30478312). 'Met-1'-linked polyubiquitin chains attached to RIPK2 recruit IKBKG/NEMO, which undergoes 'Lys-63'-linked polyubiquitination in a RIPK2-dependent process (PubMed:17562858, PubMed:22607974, PubMed:29452636, PubMed:30026309). 'Lys-63'-linked polyubiquitin chains attached to RIPK2 serve as docking sites for TAB2 and TAB3 and mediate the recruitment of MAP3K7/TAK1 to IKBKG/NEMO, inducing subsequent activation of IKBKB/IKKB (PubMed:18079694). In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:18079694). The protein kinase activity is dispensable for the NOD1 and NOD2 signaling pathways (PubMed:29452636, PubMed:30026309). Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappa-B activation by NOD2 (PubMed:21887730). Also involved in adaptive immunity: plays a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation (PubMed:14638696). Plays a role in the inactivation of RHOA in response to NGFR signaling (PubMed:26646181). {ECO:0000269|PubMed:14638696, ECO:0000269|PubMed:17054981, ECO:0000269|PubMed:17562858, ECO:0000269|PubMed:18079694, ECO:0000269|PubMed:21123652, ECO:0000269|PubMed:21887730, ECO:0000269|PubMed:22607974, ECO:0000269|PubMed:26646181, ECO:0000269|PubMed:28545134, ECO:0000269|PubMed:28656966, ECO:0000269|PubMed:29452636, ECO:0000269|PubMed:30026309, ECO:0000269|PubMed:30279485, ECO:0000269|PubMed:30478312, ECO:0000269|PubMed:9575181, ECO:0000269|PubMed:9642260}. |
| Q6UVK1 | CSPG4 | S321 | Sugiyama | Chondroitin sulfate proteoglycan 4 (Chondroitin sulfate proteoglycan NG2) (Melanoma chondroitin sulfate proteoglycan) (Melanoma-associated chondroitin sulfate proteoglycan) | Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Also functions as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades. {ECO:0000269|PubMed:10587647, ECO:0000269|PubMed:11278606, ECO:0000269|PubMed:15210734}. |
| Q99798 | ACO2 | S388 | Sugiyama | Aconitate hydratase, mitochondrial (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) | Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. {ECO:0000250|UniProtKB:P16276}. |
| P05129 | PRKCG | S600 | Sugiyama | Protein kinase C gamma type (PKC-gamma) (EC 2.7.11.13) | Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. May be involved in the regulation of hippocampal long-term potentiation (LTP), but may be not necessary for the process of synaptic plasticity. May be involved in desensitization of mu-type opioid receptor-mediated G-protein activation in the spinal cord, and may be critical for the development and/or maintenance of morphine-induced reinforcing effects in the limbic forebrain. May modulate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the phosphorylation and degradation of opioid receptors. May also contributes to chronic morphine-induced changes in nociceptive processing. Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the allodynia pain produced by peripheral inflammation. Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A) receptors. During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes, and is involved in insulin-induced inhibition of necrosis, an important mechanism for minimizing ischemic injury. Required for the elimination of multiple climbing fibers during innervation of Purkinje cells in developing cerebellum. Is activated in lens epithelial cells upon hydrogen peroxide treatment, and phosphorylates connexin-43 (GJA1/CX43), resulting in disassembly of GJA1 gap junction plaques and inhibition of gap junction activity which could provide a protective effect against oxidative stress (By similarity). Phosphorylates p53/TP53 and promotes p53/TP53-dependent apoptosis in response to DNA damage. Involved in the phase resetting of the cerebral cortex circadian clock during temporally restricted feeding. Stabilizes the core clock component BMAL1 by interfering with its ubiquitination, thus suppressing its degradation, resulting in phase resetting of the cerebral cortex clock (By similarity). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000250|UniProtKB:P63318, ECO:0000250|UniProtKB:P63319, ECO:0000269|PubMed:16377624, ECO:0000269|PubMed:36040231}. |
| P16234 | PDGFRA | S601 | Sugiyama | Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a) | Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor. {ECO:0000269|PubMed:10734113, ECO:0000269|PubMed:10947961, ECO:0000269|PubMed:11297552, ECO:0000269|PubMed:12522257, ECO:0000269|PubMed:1646396, ECO:0000269|PubMed:17087943, ECO:0000269|PubMed:1709159, ECO:0000269|PubMed:17141222, ECO:0000269|PubMed:20972453, ECO:0000269|PubMed:21224473, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:2554309, ECO:0000269|PubMed:8188664, ECO:0000269|PubMed:8760137, ECO:0000269|PubMed:8943348}. |
| Q9H6Z4 | RANBP3 | S57 | SIGNOR | Ran-binding protein 3 (RanBP3) | Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export. {ECO:0000269|PubMed:11425870, ECO:0000269|PubMed:11571268, ECO:0000269|PubMed:11932251, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:9637251}. |
| O60610 | DIAPH1 | S1235 | Sugiyama | Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1) | Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers (By similarity). Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization (By similarity). Required for cytokinesis, and transcriptional activation of the serum response factor (By similarity). DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics (By similarity). Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules and promote cell migration (By similarity). Has neurite outgrowth promoting activity. Acts in a Rho-dependent manner to recruit PFY1 to the membrane (By similarity). In hear cells, it may play a role in the regulation of actin polymerization in hair cells (PubMed:20937854, PubMed:21834987, PubMed:26912466). The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854, PubMed:21834987). It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity (PubMed:20937854, PubMed:21834987). In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (PubMed:20937854, PubMed:21834987). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (PubMed:20937854, PubMed:21834987). Plays a role in brain development (PubMed:24781755). Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity (By similarity). {ECO:0000250|UniProtKB:O08808, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:24781755, ECO:0000269|PubMed:26912466}. |
| P17987 | TCP1 | S19 | Sugiyama | T-complex protein 1 subunit alpha (TCP-1-alpha) (EC 3.6.1.-) (CCT-alpha) (Chaperonin containing T-complex polypeptide 1 subunit 1) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P42167 | TMPO | S79 | Sugiyama | Lamina-associated polypeptide 2, isoforms beta/gamma (Thymopoietin, isoforms beta/gamma) (TP beta/gamma) (Thymopoietin-related peptide isoforms beta/gamma) (TPRP isoforms beta/gamma) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)] | May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control of initiation of DNA replication through its interaction with NAKAP95.; FUNCTION: Thymopoietin (TP) and Thymopentin (TP5) may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide. |
| Q8NBP7 | PCSK9 | S666 | GPS6 | Proprotein convertase subtilisin/kexin type 9 (EC 3.4.21.-) (Neural apoptosis-regulated convertase 1) (NARC-1) (Proprotein convertase 9) (PC9) (Subtilisin/kexin-like protease PC9) | Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments (PubMed:18039658). Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation (PubMed:17461796, PubMed:18197702, PubMed:18799458, PubMed:22074827). Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner. Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway (PubMed:18660751). Inhibits epithelial Na(+) channel (ENaC)-mediated Na(+) absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation. Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways. {ECO:0000269|PubMed:17461796, ECO:0000269|PubMed:18039658, ECO:0000269|PubMed:18197702, ECO:0000269|PubMed:18660751, ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22074827, ECO:0000269|PubMed:22493497, ECO:0000269|PubMed:22580899}. |
| P05187 | ALPP | S153 | Sugiyama | Alkaline phosphatase, placental type (EC 3.1.3.1) (Alkaline phosphatase Regan isozyme) (Placental alkaline phosphatase 1) (PLAP-1) | Alkaline phosphatase that can hydrolyze various phosphate compounds. {ECO:0000269|PubMed:1939159, ECO:0000269|PubMed:25775211}. |
| P09923 | ALPI | S150 | Sugiyama | Intestinal-type alkaline phosphatase (IAP) (Intestinal alkaline phosphatase) (EC 3.1.3.1) | Alkaline phosphatase that can hydrolyze various phosphate compounds. {ECO:0000250|UniProtKB:P15693}. |
| P10696 | ALPG | S150 | Sugiyama | Alkaline phosphatase, germ cell type (EC 3.1.3.1) (ALP-1) (Alkaline phosphatase Nagao isozyme) (Alkaline phosphatase, placental-like) (Germ cell alkaline phosphatase) (GCAP) (Placental alkaline phosphatase-like) (PLAP-like) | Alkaline phosphatase that can hydrolyze various phosphate compounds. {ECO:0000269|PubMed:1939159}. |
| Q14524 | SCN5A | S539 | PSP | Sodium channel protein type 5 subunit alpha (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (hH1) | Pore-forming subunit of Nav1.5, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:1309946, PubMed:21447824, PubMed:23085483, PubMed:23420830, PubMed:25370050, PubMed:26279430, PubMed:26392562, PubMed:26776555). Nav1.5 is the predominant sodium channel expressed in myocardial cells and it is responsible for the initial upstroke of the action potential in cardiac myocytes, thereby initiating the heartbeat (PubMed:11234013, PubMed:11804990, PubMed:12569159, PubMed:1309946). Required for normal electrical conduction including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with XIRP2 (By similarity). {ECO:0000250|UniProtKB:Q9JJV9, ECO:0000269|PubMed:11234013, ECO:0000269|PubMed:11804990, ECO:0000269|PubMed:12569159, ECO:0000269|PubMed:1309946, ECO:0000269|PubMed:19074138, ECO:0000269|PubMed:21447824, ECO:0000269|PubMed:23085483, ECO:0000269|PubMed:23420830, ECO:0000269|PubMed:24167619, ECO:0000269|PubMed:25370050, ECO:0000269|PubMed:26279430, ECO:0000269|PubMed:26392562, ECO:0000269|PubMed:26776555}. |
| Q9Y4K4 | MAP4K5 | S28 | Sugiyama | Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (Kinase homologous to SPS1/STE20) (KHS) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) | May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. {ECO:0000269|PubMed:9038372}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-5683826 | Surfactant metabolism | 0.000219 | 3.659 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.000112 | 3.953 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 0.000278 | 3.556 |
| R-HSA-5688849 | Defective CSF2RB causes SMDP5 | 0.003164 | 2.500 |
| R-HSA-5688890 | Defective CSF2RA causes SMDP4 | 0.003164 | 2.500 |
| R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 0.003164 | 2.500 |
| R-HSA-9854909 | Regulation of MITF-M dependent genes involved in invasion | 0.002439 | 2.613 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 0.002546 | 2.594 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 0.002830 | 2.548 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.004474 | 2.349 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 0.004879 | 2.312 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 0.005864 | 2.232 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 0.005864 | 2.232 |
| R-HSA-422475 | Axon guidance | 0.005816 | 2.235 |
| R-HSA-937042 | IRAK2 mediated activation of TAK1 complex | 0.006932 | 2.159 |
| R-HSA-9674415 | Drug resistance of PDGFR mutants | 0.010195 | 1.992 |
| R-HSA-9674428 | PDGFR mutants bind TKIs | 0.010195 | 1.992 |
| R-HSA-9674403 | Regorafenib-resistant PDGFR mutants | 0.010195 | 1.992 |
| R-HSA-5687868 | Defective SFTPA2 causes IPF | 0.010195 | 1.992 |
| R-HSA-9674396 | Imatinib-resistant PDGFR mutants | 0.010195 | 1.992 |
| R-HSA-9674404 | Sorafenib-resistant PDGFR mutants | 0.010195 | 1.992 |
| R-HSA-9674401 | Sunitinib-resistant PDGFR mutants | 0.010195 | 1.992 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 0.008081 | 2.093 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.010152 | 1.993 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.008932 | 2.049 |
| R-HSA-9645460 | Alpha-protein kinase 1 signaling pathway | 0.009310 | 2.031 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.008329 | 2.079 |
| R-HSA-68886 | M Phase | 0.009056 | 2.043 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.008099 | 2.092 |
| R-HSA-9675108 | Nervous system development | 0.009595 | 2.018 |
| R-HSA-4641258 | Degradation of DVL | 0.010797 | 1.967 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.010797 | 1.967 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 0.011999 | 1.921 |
| R-HSA-5687613 | Diseases associated with surfactant metabolism | 0.011999 | 1.921 |
| R-HSA-4086400 | PCP/CE pathway | 0.012283 | 1.911 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 0.012156 | 1.915 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 0.011999 | 1.921 |
| R-HSA-9659379 | Sensory processing of sound | 0.012765 | 1.894 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.014372 | 1.842 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 0.016586 | 1.780 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 0.014985 | 1.824 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.015353 | 1.814 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.014372 | 1.842 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 0.016586 | 1.780 |
| R-HSA-69481 | G2/M Checkpoints | 0.016048 | 1.795 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.018541 | 1.732 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.019446 | 1.711 |
| R-HSA-193639 | p75NTR signals via NF-kB | 0.016586 | 1.780 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.018366 | 1.736 |
| R-HSA-1640170 | Cell Cycle | 0.018371 | 1.736 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.013571 | 1.867 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.013571 | 1.867 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.014794 | 1.830 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.014794 | 1.830 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.017054 | 1.768 |
| R-HSA-391160 | Signal regulatory protein family interactions | 0.014985 | 1.824 |
| R-HSA-9036092 | Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus... | 0.020286 | 1.693 |
| R-HSA-5659996 | RPIA deficiency: failed conversion of R5P to RU5P | 0.020286 | 1.693 |
| R-HSA-6791461 | RPIA deficiency: failed conversion of RU5P to R5P | 0.020286 | 1.693 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.022309 | 1.652 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.024338 | 1.614 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.023311 | 1.632 |
| R-HSA-5617833 | Cilium Assembly | 0.021411 | 1.669 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.024160 | 1.617 |
| R-HSA-1500931 | Cell-Cell communication | 0.023248 | 1.634 |
| R-HSA-392517 | Rap1 signalling | 0.025601 | 1.592 |
| R-HSA-72649 | Translation initiation complex formation | 0.026463 | 1.577 |
| R-HSA-5339700 | Signaling by TCF7L2 mutants | 0.030275 | 1.519 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 0.049950 | 1.301 |
| R-HSA-392023 | Adrenaline signalling through Alpha-2 adrenergic receptor | 0.049950 | 1.301 |
| R-HSA-8941237 | Invadopodia formation | 0.049950 | 1.301 |
| R-HSA-9706377 | FLT3 signaling by CBL mutants | 0.069228 | 1.160 |
| R-HSA-9017802 | Noncanonical activation of NOTCH3 | 0.078721 | 1.104 |
| R-HSA-3595174 | Defective CHST14 causes EDS, musculocontractural type | 0.088118 | 1.055 |
| R-HSA-3595172 | Defective CHST3 causes SEDCJD | 0.088118 | 1.055 |
| R-HSA-9732724 | IFNG signaling activates MAPKs | 0.097419 | 1.011 |
| R-HSA-114516 | Disinhibition of SNARE formation | 0.097419 | 1.011 |
| R-HSA-3595177 | Defective CHSY1 causes TPBS | 0.097419 | 1.011 |
| R-HSA-201688 | WNT mediated activation of DVL | 0.115740 | 0.937 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 0.124761 | 0.904 |
| R-HSA-429947 | Deadenylation of mRNA | 0.038448 | 1.415 |
| R-HSA-2022923 | DS-GAG biosynthesis | 0.142531 | 0.846 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.151280 | 0.820 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.045613 | 1.341 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.055858 | 1.253 |
| R-HSA-9673767 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 0.177000 | 0.752 |
| R-HSA-9673770 | Signaling by PDGFRA extracellular domain mutants | 0.177000 | 0.752 |
| R-HSA-5656121 | Translesion synthesis by POLI | 0.185400 | 0.732 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.028685 | 1.542 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.075466 | 1.122 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.084446 | 1.073 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.037213 | 1.429 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.037213 | 1.429 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.039863 | 1.399 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.090604 | 1.043 |
| R-HSA-167161 | HIV Transcription Initiation | 0.090604 | 1.043 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.090604 | 1.043 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.041223 | 1.385 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.051384 | 1.289 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.106541 | 0.972 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.106541 | 0.972 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.106541 | 0.972 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.106541 | 0.972 |
| R-HSA-380287 | Centrosome maturation | 0.054491 | 1.264 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.073115 | 1.136 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.073115 | 1.136 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.078628 | 1.104 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.086252 | 1.064 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.126352 | 0.898 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.135523 | 0.868 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.135523 | 0.868 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.071318 | 1.147 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.082402 | 1.084 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.043174 | 1.365 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.031002 | 1.509 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.090604 | 1.043 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.103296 | 0.986 |
| R-HSA-110312 | Translesion synthesis by REV1 | 0.177000 | 0.752 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.076264 | 1.118 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.106541 | 0.972 |
| R-HSA-5635851 | GLI proteins bind promoters of Hh responsive genes to promote transcription | 0.078721 | 1.104 |
| R-HSA-174490 | Membrane binding and targetting of GAG proteins | 0.159941 | 0.796 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.055858 | 1.253 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.149694 | 0.825 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.096890 | 1.014 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.096204 | 1.017 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 0.106626 | 0.972 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 0.142531 | 0.846 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 0.185400 | 0.732 |
| R-HSA-9664420 | Killing mechanisms | 0.185400 | 0.732 |
| R-HSA-5673000 | RAF activation | 0.066819 | 1.175 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.069663 | 1.157 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.069663 | 1.157 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.035924 | 1.445 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.090604 | 1.043 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.090604 | 1.043 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.109814 | 0.959 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.126556 | 0.898 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.129974 | 0.886 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.129974 | 0.886 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.149694 | 0.825 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 0.151280 | 0.820 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.136874 | 0.864 |
| R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 0.168514 | 0.773 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.051384 | 1.289 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.126556 | 0.898 |
| R-HSA-388479 | Vasopressin-like receptors | 0.059638 | 1.224 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.087509 | 1.058 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.106601 | 0.972 |
| R-HSA-9907900 | Proteasome assembly | 0.100078 | 1.000 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.103296 | 0.986 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.140354 | 0.853 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.128623 | 0.891 |
| R-HSA-5624138 | Trafficking of myristoylated proteins to the cilium | 0.069228 | 1.160 |
| R-HSA-6791465 | Pentose phosphate pathway disease | 0.078721 | 1.104 |
| R-HSA-8948747 | Regulation of PTEN localization | 0.097419 | 1.011 |
| R-HSA-3785653 | Myoclonic epilepsy of Lafora | 0.106626 | 0.972 |
| R-HSA-176974 | Unwinding of DNA | 0.115740 | 0.937 |
| R-HSA-5689877 | Josephin domain DUBs | 0.124761 | 0.904 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 0.177000 | 0.752 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 0.072545 | 1.139 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.075466 | 1.122 |
| R-HSA-4641257 | Degradation of AXIN | 0.075466 | 1.122 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.075466 | 1.122 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.090604 | 1.043 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.133414 | 0.875 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.040337 | 1.394 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.028084 | 1.552 |
| R-HSA-170968 | Frs2-mediated activation | 0.159941 | 0.796 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.129974 | 0.886 |
| R-HSA-418597 | G alpha (z) signalling events | 0.136874 | 0.864 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.061253 | 1.213 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.048367 | 1.315 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 0.168514 | 0.773 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.081418 | 1.089 |
| R-HSA-169893 | Prolonged ERK activation events | 0.185400 | 0.732 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.099597 | 1.002 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.064333 | 1.192 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 0.106626 | 0.972 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.045613 | 1.341 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 0.064015 | 1.194 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 0.066819 | 1.175 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.066819 | 1.175 |
| R-HSA-169911 | Regulation of Apoptosis | 0.069663 | 1.157 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.039863 | 1.399 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.090604 | 1.043 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.150906 | 0.821 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.090178 | 1.045 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.076264 | 1.118 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.154585 | 0.811 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.107734 | 0.968 |
| R-HSA-418889 | Caspase activation via Dependence Receptors in the absence of ligand | 0.115740 | 0.937 |
| R-HSA-9839394 | TGFBR3 expression | 0.040785 | 1.390 |
| R-HSA-418360 | Platelet calcium homeostasis | 0.050641 | 1.295 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 0.177000 | 0.752 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.103296 | 0.986 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.048103 | 1.318 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.050641 | 1.295 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.066819 | 1.175 |
| R-HSA-187706 | Signalling to p38 via RIT and RIN | 0.078721 | 1.104 |
| R-HSA-170984 | ARMS-mediated activation | 0.115740 | 0.937 |
| R-HSA-1433617 | Regulation of signaling by NODAL | 0.115740 | 0.937 |
| R-HSA-418359 | Reduction of cytosolic Ca++ levels | 0.142531 | 0.846 |
| R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer | 0.151280 | 0.820 |
| R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants | 0.151280 | 0.820 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 0.177000 | 0.752 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 0.177000 | 0.752 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.061253 | 1.213 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.061253 | 1.213 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 0.066819 | 1.175 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.084446 | 1.073 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.084446 | 1.073 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.087509 | 1.058 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.087509 | 1.058 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.106541 | 0.972 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 0.116438 | 0.934 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.069541 | 1.158 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.126352 | 0.898 |
| R-HSA-68877 | Mitotic Prometaphase | 0.174148 | 0.759 |
| R-HSA-75893 | TNF signaling | 0.140354 | 0.853 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.161851 | 0.791 |
| R-HSA-9766229 | Degradation of CDH1 | 0.116438 | 0.934 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.031552 | 1.501 |
| R-HSA-69239 | Synthesis of DNA | 0.124095 | 0.906 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.028685 | 1.542 |
| R-HSA-4641265 | Repression of WNT target genes | 0.151280 | 0.820 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.096890 | 1.014 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.100078 | 1.000 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.103296 | 0.986 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.140194 | 0.853 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 0.106541 | 0.972 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.176542 | 0.753 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 0.033937 | 1.469 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 0.142531 | 0.846 |
| R-HSA-69541 | Stabilization of p53 | 0.081418 | 1.089 |
| R-HSA-167172 | Transcription of the HIV genome | 0.183398 | 0.737 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.028886 | 1.539 |
| R-HSA-8941284 | RUNX2 regulates chondrocyte maturation | 0.069228 | 1.160 |
| R-HSA-389542 | NADPH regeneration | 0.088118 | 1.055 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.097419 | 1.011 |
| R-HSA-9683686 | Maturation of spike protein | 0.124761 | 0.904 |
| R-HSA-209560 | NF-kB is activated and signals survival | 0.142531 | 0.846 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 0.151280 | 0.820 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 0.151280 | 0.820 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 0.168514 | 0.773 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.081418 | 1.089 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.100311 | 0.999 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.048367 | 1.315 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.158025 | 0.801 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.038526 | 1.414 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.130909 | 0.883 |
| R-HSA-5693538 | Homology Directed Repair | 0.154520 | 0.811 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.051384 | 1.289 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 0.066819 | 1.175 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.150906 | 0.821 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.130909 | 0.883 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.119627 | 0.922 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 0.115740 | 0.937 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.087509 | 1.058 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.103296 | 0.986 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.098249 | 1.008 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.046893 | 1.329 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.126352 | 0.898 |
| R-HSA-9762293 | Regulation of CDH11 gene transcription | 0.115740 | 0.937 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.075466 | 1.122 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.028917 | 1.539 |
| R-HSA-73887 | Death Receptor Signaling | 0.032923 | 1.482 |
| R-HSA-202424 | Downstream TCR signaling | 0.082402 | 1.084 |
| R-HSA-69275 | G2/M Transition | 0.060971 | 1.215 |
| R-HSA-9694493 | Maturation of protein E | 0.078721 | 1.104 |
| R-HSA-9683683 | Maturation of protein E | 0.078721 | 1.104 |
| R-HSA-8964011 | HDL clearance | 0.088118 | 1.055 |
| R-HSA-391906 | Leukotriene receptors | 0.088118 | 1.055 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 0.133691 | 0.874 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 0.185400 | 0.732 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.059315 | 1.227 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.123160 | 0.910 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.128623 | 0.891 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.063003 | 1.201 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.066122 | 1.180 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.132312 | 0.878 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.111505 | 0.953 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.143853 | 0.842 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.179735 | 0.745 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.128623 | 0.891 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.102391 | 0.990 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.102391 | 0.990 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.102391 | 0.990 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 0.185400 | 0.732 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.103296 | 0.986 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.103296 | 0.986 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.116438 | 0.934 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.116438 | 0.934 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.071318 | 1.147 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.165207 | 0.782 |
| R-HSA-3214842 | HDMs demethylate histones | 0.040785 | 1.390 |
| R-HSA-5578775 | Ion homeostasis | 0.140354 | 0.853 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.073510 | 1.134 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.138120 | 0.860 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.154457 | 0.811 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.156952 | 0.804 |
| R-HSA-390696 | Adrenoceptors | 0.106626 | 0.972 |
| R-HSA-9637628 | Modulation by Mtb of host immune system | 0.106626 | 0.972 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 0.159941 | 0.796 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.133414 | 0.875 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.154457 | 0.811 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.156952 | 0.804 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.137852 | 0.861 |
| R-HSA-69206 | G1/S Transition | 0.174295 | 0.759 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.098525 | 1.006 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.144918 | 0.839 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.046893 | 1.329 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.069663 | 1.157 |
| R-HSA-68882 | Mitotic Anaphase | 0.035612 | 1.448 |
| R-HSA-9664873 | Pexophagy | 0.124761 | 0.904 |
| R-HSA-5686938 | Regulation of TLR by endogenous ligand | 0.066819 | 1.175 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.036231 | 1.441 |
| R-HSA-68875 | Mitotic Prophase | 0.049988 | 1.301 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 0.124761 | 0.904 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 0.177000 | 0.752 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.140354 | 0.853 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.161609 | 0.792 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.027296 | 1.564 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.123160 | 0.910 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.106541 | 0.972 |
| R-HSA-162582 | Signal Transduction | 0.053602 | 1.271 |
| R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 0.106626 | 0.972 |
| R-HSA-9708530 | Regulation of BACH1 activity | 0.185400 | 0.732 |
| R-HSA-450294 | MAP kinase activation | 0.034658 | 1.460 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.054491 | 1.264 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.121853 | 0.914 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.096890 | 1.014 |
| R-HSA-418990 | Adherens junctions interactions | 0.036857 | 1.433 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.089286 | 1.049 |
| R-HSA-421270 | Cell-cell junction organization | 0.061491 | 1.211 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.103296 | 0.986 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.088206 | 1.055 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.049865 | 1.302 |
| R-HSA-448424 | Interleukin-17 signaling | 0.046893 | 1.329 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.111505 | 0.953 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.136874 | 0.864 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.126556 | 0.898 |
| R-HSA-446728 | Cell junction organization | 0.087502 | 1.058 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.140354 | 0.853 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.161609 | 0.792 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.156952 | 0.804 |
| R-HSA-202403 | TCR signaling | 0.130909 | 0.883 |
| R-HSA-9706369 | Negative regulation of FLT3 | 0.185400 | 0.732 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.179735 | 0.745 |
| R-HSA-9683701 | Translation of Structural Proteins | 0.090604 | 1.043 |
| R-HSA-1266738 | Developmental Biology | 0.105058 | 0.979 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.050475 | 1.297 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.139581 | 0.855 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.161851 | 0.791 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.172446 | 0.763 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.186369 | 0.730 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.190755 | 0.720 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.190755 | 0.720 |
| R-HSA-5576891 | Cardiac conduction | 0.192148 | 0.716 |
| R-HSA-5655862 | Translesion synthesis by POLK | 0.193715 | 0.713 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 0.193715 | 0.713 |
| R-HSA-4420332 | Defective B3GALT6 causes EDSP2 and SEMDJL1 | 0.193715 | 0.713 |
| R-HSA-3560783 | Defective B4GALT7 causes EDS, progeroid type | 0.193715 | 0.713 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 0.193715 | 0.713 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.193715 | 0.713 |
| R-HSA-975110 | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | 0.193715 | 0.713 |
| R-HSA-6787450 | tRNA modification in the mitochondrion | 0.193715 | 0.713 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.194448 | 0.711 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.194448 | 0.711 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.198151 | 0.703 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.201863 | 0.695 |
| R-HSA-5663084 | Diseases of carbohydrate metabolism | 0.201863 | 0.695 |
| R-HSA-3560801 | Defective B3GAT3 causes JDSSDHD | 0.201945 | 0.695 |
| R-HSA-4641263 | Regulation of FZD by ubiquitination | 0.201945 | 0.695 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 0.201945 | 0.695 |
| R-HSA-3229121 | Glycogen storage diseases | 0.201945 | 0.695 |
| R-HSA-109582 | Hemostasis | 0.204727 | 0.689 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.205582 | 0.687 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.205582 | 0.687 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.205582 | 0.687 |
| R-HSA-917937 | Iron uptake and transport | 0.209309 | 0.679 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.210092 | 0.678 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 0.210092 | 0.678 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 0.210092 | 0.678 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.210092 | 0.678 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.210092 | 0.678 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.210092 | 0.678 |
| R-HSA-5689603 | UCH proteinases | 0.213043 | 0.672 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.213043 | 0.672 |
| R-HSA-6807070 | PTEN Regulation | 0.215735 | 0.666 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.216783 | 0.664 |
| R-HSA-110320 | Translesion Synthesis by POLH | 0.218156 | 0.661 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 0.218156 | 0.661 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 0.218156 | 0.661 |
| R-HSA-912631 | Regulation of signaling by CBL | 0.218156 | 0.661 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 0.218156 | 0.661 |
| R-HSA-5619084 | ABC transporter disorders | 0.220530 | 0.657 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.226139 | 0.646 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 0.226139 | 0.646 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.226139 | 0.646 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 0.226139 | 0.646 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 0.226139 | 0.646 |
| R-HSA-1181150 | Signaling by NODAL | 0.226139 | 0.646 |
| R-HSA-3322077 | Glycogen synthesis | 0.226139 | 0.646 |
| R-HSA-391903 | Eicosanoid ligand-binding receptors | 0.226139 | 0.646 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.226410 | 0.645 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.226410 | 0.645 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.228038 | 0.642 |
| R-HSA-195721 | Signaling by WNT | 0.228513 | 0.641 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.229096 | 0.640 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.231787 | 0.635 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.234040 | 0.631 |
| R-HSA-9636383 | Prevention of phagosomal-lysosomal fusion | 0.234040 | 0.631 |
| R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 0.234040 | 0.631 |
| R-HSA-9931295 | PD-L1(CD274) glycosylation and translocation to plasma membrane | 0.234040 | 0.631 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.234040 | 0.631 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.234040 | 0.631 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.239333 | 0.621 |
| R-HSA-2022870 | CS-GAG biosynthesis | 0.241861 | 0.616 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.241861 | 0.616 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.241861 | 0.616 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.241861 | 0.616 |
| R-HSA-175474 | Assembly Of The HIV Virion | 0.241861 | 0.616 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.241861 | 0.616 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 0.241861 | 0.616 |
| R-HSA-69242 | S Phase | 0.242608 | 0.615 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.246047 | 0.609 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.246880 | 0.608 |
| R-HSA-162906 | HIV Infection | 0.248260 | 0.605 |
| R-HSA-199991 | Membrane Trafficking | 0.249053 | 0.604 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.249603 | 0.603 |
| R-HSA-8964038 | LDL clearance | 0.249603 | 0.603 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.249603 | 0.603 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.249603 | 0.603 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.250478 | 0.601 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.250656 | 0.601 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.250779 | 0.601 |
| R-HSA-69306 | DNA Replication | 0.256249 | 0.591 |
| R-HSA-9609507 | Protein localization | 0.256249 | 0.591 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.256249 | 0.591 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 0.257266 | 0.590 |
| R-HSA-9830674 | Formation of the ureteric bud | 0.257266 | 0.590 |
| R-HSA-70268 | Pyruvate metabolism | 0.258214 | 0.588 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.258214 | 0.588 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.258990 | 0.587 |
| R-HSA-156902 | Peptide chain elongation | 0.261994 | 0.582 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 0.264852 | 0.577 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.264852 | 0.577 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.264852 | 0.577 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.265775 | 0.575 |
| R-HSA-162587 | HIV Life Cycle | 0.267238 | 0.573 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.269994 | 0.569 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.272360 | 0.565 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.273337 | 0.563 |
| R-HSA-157118 | Signaling by NOTCH | 0.277401 | 0.557 |
| R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | 0.279792 | 0.553 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 0.279792 | 0.553 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 0.279792 | 0.553 |
| R-HSA-525793 | Myogenesis | 0.279792 | 0.553 |
| R-HSA-9637687 | Suppression of phagosomal maturation | 0.279792 | 0.553 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.279792 | 0.553 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.280896 | 0.551 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.280896 | 0.551 |
| R-HSA-109581 | Apoptosis | 0.281050 | 0.551 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 0.287149 | 0.542 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.287149 | 0.542 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.287149 | 0.542 |
| R-HSA-901032 | ER Quality Control Compartment (ERQC) | 0.287149 | 0.542 |
| R-HSA-264876 | Insulin processing | 0.287149 | 0.542 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.292222 | 0.534 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 0.294431 | 0.531 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.294431 | 0.531 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.295993 | 0.529 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.295993 | 0.529 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.299761 | 0.523 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 0.301639 | 0.521 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.301639 | 0.521 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.301639 | 0.521 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.301639 | 0.521 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.301639 | 0.521 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 0.301639 | 0.521 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.303526 | 0.518 |
| R-HSA-190236 | Signaling by FGFR | 0.307288 | 0.512 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.308774 | 0.510 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.308774 | 0.510 |
| R-HSA-5688426 | Deubiquitination | 0.311668 | 0.506 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.313915 | 0.503 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.314799 | 0.502 |
| R-HSA-186763 | Downstream signal transduction | 0.315836 | 0.501 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 0.315836 | 0.501 |
| R-HSA-162588 | Budding and maturation of HIV virion | 0.315836 | 0.501 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.315836 | 0.501 |
| R-HSA-182971 | EGFR downregulation | 0.315836 | 0.501 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.315836 | 0.501 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.318548 | 0.497 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.322292 | 0.492 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 0.322827 | 0.491 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.322827 | 0.491 |
| R-HSA-69190 | DNA strand elongation | 0.322827 | 0.491 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.322827 | 0.491 |
| R-HSA-1538133 | G0 and Early G1 | 0.322827 | 0.491 |
| R-HSA-192823 | Viral mRNA Translation | 0.326032 | 0.487 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.327955 | 0.484 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.329747 | 0.482 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.329747 | 0.482 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.329747 | 0.482 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.329747 | 0.482 |
| R-HSA-9930044 | Nuclear RNA decay | 0.329747 | 0.482 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.329747 | 0.482 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.329766 | 0.482 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.329766 | 0.482 |
| R-HSA-163125 | Post-translational modification: synthesis of GPI-anchored proteins | 0.333494 | 0.477 |
| R-HSA-2559583 | Cellular Senescence | 0.333957 | 0.476 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.336596 | 0.473 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.336596 | 0.473 |
| R-HSA-2024101 | CS/DS degradation | 0.336596 | 0.473 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.336596 | 0.473 |
| R-HSA-418346 | Platelet homeostasis | 0.340933 | 0.467 |
| R-HSA-1971475 | Glycosaminoglycan-protein linkage region biosynthesis | 0.343376 | 0.464 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 0.343376 | 0.464 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.343376 | 0.464 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.343376 | 0.464 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.343376 | 0.464 |
| R-HSA-1980145 | Signaling by NOTCH2 | 0.343376 | 0.464 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.343376 | 0.464 |
| R-HSA-5205647 | Mitophagy | 0.343376 | 0.464 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.344643 | 0.463 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.348346 | 0.458 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.348346 | 0.458 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.348346 | 0.458 |
| R-HSA-187687 | Signalling to ERKs | 0.350087 | 0.456 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.350087 | 0.456 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.355584 | 0.449 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.356730 | 0.448 |
| R-HSA-111933 | Calmodulin induced events | 0.356730 | 0.448 |
| R-HSA-111997 | CaM pathway | 0.356730 | 0.448 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.356730 | 0.448 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.356730 | 0.448 |
| R-HSA-983712 | Ion channel transport | 0.359035 | 0.445 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.369814 | 0.432 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.369814 | 0.432 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.374114 | 0.427 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 0.376256 | 0.425 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.376256 | 0.425 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.376256 | 0.425 |
| R-HSA-71336 | Pentose phosphate pathway | 0.376256 | 0.425 |
| R-HSA-9648002 | RAS processing | 0.376256 | 0.425 |
| R-HSA-9679506 | SARS-CoV Infections | 0.377654 | 0.423 |
| R-HSA-9646399 | Aggrephagy | 0.382633 | 0.417 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.382633 | 0.417 |
| R-HSA-9854311 | Maturation of TCA enzymes and regulation of TCA cycle | 0.382633 | 0.417 |
| R-HSA-8982491 | Glycogen metabolism | 0.382633 | 0.417 |
| R-HSA-373760 | L1CAM interactions | 0.384961 | 0.415 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.388945 | 0.410 |
| R-HSA-9694548 | Maturation of spike protein | 0.388945 | 0.410 |
| R-HSA-9607240 | FLT3 Signaling | 0.388945 | 0.410 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.395193 | 0.403 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.395193 | 0.403 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.397755 | 0.400 |
| R-HSA-913531 | Interferon Signaling | 0.398752 | 0.399 |
| R-HSA-111996 | Ca-dependent events | 0.401377 | 0.396 |
| R-HSA-165159 | MTOR signalling | 0.401377 | 0.396 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.401377 | 0.396 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.404128 | 0.393 |
| R-HSA-5357801 | Programmed Cell Death | 0.405979 | 0.391 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.407499 | 0.390 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 0.407499 | 0.390 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.410064 | 0.387 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.413558 | 0.383 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.413558 | 0.383 |
| R-HSA-69236 | G1 Phase | 0.413558 | 0.383 |
| R-HSA-375280 | Amine ligand-binding receptors | 0.413558 | 0.383 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.413611 | 0.383 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.413611 | 0.383 |
| R-HSA-3560782 | Diseases associated with glycosaminoglycan metabolism | 0.419556 | 0.377 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 0.419556 | 0.377 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.419556 | 0.377 |
| R-HSA-9824272 | Somitogenesis | 0.419556 | 0.377 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.419556 | 0.377 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.420671 | 0.376 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.420671 | 0.376 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.420671 | 0.376 |
| R-HSA-397014 | Muscle contraction | 0.425039 | 0.372 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.425493 | 0.371 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.425493 | 0.371 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.425493 | 0.371 |
| R-HSA-9675135 | Diseases of DNA repair | 0.425493 | 0.371 |
| R-HSA-388396 | GPCR downstream signalling | 0.428316 | 0.368 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.431181 | 0.365 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.437186 | 0.359 |
| R-HSA-70263 | Gluconeogenesis | 0.437186 | 0.359 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.437186 | 0.359 |
| R-HSA-73893 | DNA Damage Bypass | 0.442944 | 0.354 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.442944 | 0.354 |
| R-HSA-9843745 | Adipogenesis | 0.445036 | 0.352 |
| R-HSA-9909396 | Circadian clock | 0.448471 | 0.348 |
| R-HSA-8951664 | Neddylation | 0.449230 | 0.348 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.451894 | 0.345 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.459867 | 0.337 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.459867 | 0.337 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.465394 | 0.332 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.465394 | 0.332 |
| R-HSA-1793185 | Chondroitin sulfate/dermatan sulfate metabolism | 0.476280 | 0.322 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.477912 | 0.321 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.481640 | 0.317 |
| R-HSA-177929 | Signaling by EGFR | 0.481640 | 0.317 |
| R-HSA-8935690 | Digestion | 0.481640 | 0.317 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.483430 | 0.316 |
| R-HSA-5668914 | Diseases of metabolism | 0.486537 | 0.313 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.486945 | 0.313 |
| R-HSA-1483166 | Synthesis of PA | 0.486945 | 0.313 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.486945 | 0.313 |
| R-HSA-72766 | Translation | 0.490437 | 0.309 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.492197 | 0.308 |
| R-HSA-9033241 | Peroxisomal protein import | 0.497395 | 0.303 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.502540 | 0.299 |
| R-HSA-983189 | Kinesins | 0.502540 | 0.299 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.502540 | 0.299 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.502540 | 0.299 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.502540 | 0.299 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.502540 | 0.299 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.502540 | 0.299 |
| R-HSA-351202 | Metabolism of polyamines | 0.502540 | 0.299 |
| R-HSA-445717 | Aquaporin-mediated transport | 0.507633 | 0.294 |
| R-HSA-112043 | PLC beta mediated events | 0.507633 | 0.294 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.507633 | 0.294 |
| R-HSA-166520 | Signaling by NTRKs | 0.508169 | 0.294 |
| R-HSA-186797 | Signaling by PDGF | 0.512674 | 0.290 |
| R-HSA-1268020 | Mitochondrial protein import | 0.512674 | 0.290 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.514541 | 0.289 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.516603 | 0.287 |
| R-HSA-8953854 | Metabolism of RNA | 0.516663 | 0.287 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.517663 | 0.286 |
| R-HSA-373755 | Semaphorin interactions | 0.517663 | 0.286 |
| R-HSA-8963743 | Digestion and absorption | 0.517663 | 0.286 |
| R-HSA-8848021 | Signaling by PTK6 | 0.517663 | 0.286 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.517663 | 0.286 |
| R-HSA-4839726 | Chromatin organization | 0.521607 | 0.283 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.522602 | 0.282 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.527122 | 0.278 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.530233 | 0.276 |
| R-HSA-9830369 | Kidney development | 0.537119 | 0.270 |
| R-HSA-112040 | G-protein mediated events | 0.537119 | 0.270 |
| R-HSA-9711097 | Cellular response to starvation | 0.539483 | 0.268 |
| R-HSA-5218859 | Regulated Necrosis | 0.541860 | 0.266 |
| R-HSA-877300 | Interferon gamma signaling | 0.542538 | 0.266 |
| R-HSA-372790 | Signaling by GPCR | 0.547577 | 0.262 |
| R-HSA-9840310 | Glycosphingolipid catabolism | 0.551197 | 0.259 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.551197 | 0.259 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.555795 | 0.255 |
| R-HSA-8978934 | Metabolism of cofactors | 0.555795 | 0.255 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.557605 | 0.254 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.558607 | 0.253 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.560345 | 0.252 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.560345 | 0.252 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.567698 | 0.246 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.569308 | 0.245 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.569308 | 0.245 |
| R-HSA-8852135 | Protein ubiquitination | 0.573721 | 0.241 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.573721 | 0.241 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 0.573721 | 0.241 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.578089 | 0.238 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.578105 | 0.238 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.583833 | 0.234 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.586677 | 0.232 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.590929 | 0.228 |
| R-HSA-6806834 | Signaling by MET | 0.595121 | 0.225 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.595121 | 0.225 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.596047 | 0.225 |
| R-HSA-977225 | Amyloid fiber formation | 0.599272 | 0.222 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.603379 | 0.219 |
| R-HSA-168255 | Influenza Infection | 0.603435 | 0.219 |
| R-HSA-392499 | Metabolism of proteins | 0.610596 | 0.214 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.611470 | 0.214 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.617195 | 0.210 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.619396 | 0.208 |
| R-HSA-375276 | Peptide ligand-binding receptors | 0.622336 | 0.206 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.623299 | 0.205 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.627162 | 0.203 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.627608 | 0.202 |
| R-HSA-9663891 | Selective autophagy | 0.630986 | 0.200 |
| R-HSA-420499 | Class C/3 (Metabotropic glutamate/pheromone receptors) | 0.630986 | 0.200 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.634805 | 0.197 |
| R-HSA-418594 | G alpha (i) signalling events | 0.641293 | 0.193 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.643084 | 0.192 |
| R-HSA-391251 | Protein folding | 0.649527 | 0.187 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.649527 | 0.187 |
| R-HSA-449147 | Signaling by Interleukins | 0.652750 | 0.185 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.653122 | 0.185 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.656681 | 0.183 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.656681 | 0.183 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.658051 | 0.182 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.658051 | 0.182 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.660204 | 0.180 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.667142 | 0.176 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.667142 | 0.176 |
| R-HSA-72172 | mRNA Splicing | 0.670140 | 0.174 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.673939 | 0.171 |
| R-HSA-422356 | Regulation of insulin secretion | 0.673939 | 0.171 |
| R-HSA-6805567 | Keratinization | 0.674878 | 0.171 |
| R-HSA-3214847 | HATs acetylate histones | 0.677285 | 0.169 |
| R-HSA-70171 | Glycolysis | 0.680598 | 0.167 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.684834 | 0.164 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.688764 | 0.162 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.691031 | 0.161 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.691048 | 0.160 |
| R-HSA-111885 | Opioid Signalling | 0.693513 | 0.159 |
| R-HSA-9833110 | RSV-host interactions | 0.696660 | 0.157 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.699774 | 0.155 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.705909 | 0.151 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.705909 | 0.151 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.717656 | 0.144 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.721480 | 0.142 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.723575 | 0.141 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.729226 | 0.137 |
| R-HSA-72312 | rRNA processing | 0.731578 | 0.136 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.734762 | 0.134 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.734762 | 0.134 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.740185 | 0.131 |
| R-HSA-70326 | Glucose metabolism | 0.740185 | 0.131 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.740185 | 0.131 |
| R-HSA-112316 | Neuronal System | 0.740781 | 0.130 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.742855 | 0.129 |
| R-HSA-9824446 | Viral Infection Pathways | 0.745760 | 0.127 |
| R-HSA-73894 | DNA Repair | 0.749387 | 0.125 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 0.750704 | 0.125 |
| R-HSA-500792 | GPCR ligand binding | 0.752388 | 0.124 |
| R-HSA-1660662 | Glycosphingolipid metabolism | 0.755803 | 0.122 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.755803 | 0.122 |
| R-HSA-194138 | Signaling by VEGF | 0.763259 | 0.117 |
| R-HSA-114608 | Platelet degranulation | 0.768103 | 0.115 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.775185 | 0.111 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.776290 | 0.110 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.782052 | 0.107 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.788054 | 0.103 |
| R-HSA-416476 | G alpha (q) signalling events | 0.789689 | 0.103 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.793037 | 0.101 |
| R-HSA-163685 | Integration of energy metabolism | 0.793037 | 0.101 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.795167 | 0.100 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.801427 | 0.096 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.801427 | 0.096 |
| R-HSA-9664407 | Parasite infection | 0.801427 | 0.096 |
| R-HSA-1632852 | Macroautophagy | 0.803471 | 0.095 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.803471 | 0.095 |
| R-HSA-382551 | Transport of small molecules | 0.811539 | 0.091 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.812927 | 0.090 |
| R-HSA-9658195 | Leishmania infection | 0.815847 | 0.088 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.815847 | 0.088 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.817207 | 0.088 |
| R-HSA-9758941 | Gastrulation | 0.820953 | 0.086 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.822797 | 0.085 |
| R-HSA-168249 | Innate Immune System | 0.824553 | 0.084 |
| R-HSA-1989781 | PPARA activates gene expression | 0.831740 | 0.080 |
| R-HSA-9612973 | Autophagy | 0.833473 | 0.079 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.834663 | 0.078 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.835189 | 0.078 |
| R-HSA-5619102 | SLC transporter disorders | 0.851413 | 0.070 |
| R-HSA-72306 | tRNA processing | 0.857448 | 0.067 |
| R-HSA-418555 | G alpha (s) signalling events | 0.858919 | 0.066 |
| R-HSA-1280218 | Adaptive Immune System | 0.861251 | 0.065 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.863240 | 0.064 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.868457 | 0.061 |
| R-HSA-6798695 | Neutrophil degranulation | 0.870355 | 0.060 |
| R-HSA-3781865 | Diseases of glycosylation | 0.876717 | 0.057 |
| R-HSA-1643685 | Disease | 0.881150 | 0.055 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 0.887712 | 0.052 |
| R-HSA-597592 | Post-translational protein modification | 0.888694 | 0.051 |
| R-HSA-428157 | Sphingolipid metabolism | 0.896665 | 0.047 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.897733 | 0.047 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.898790 | 0.046 |
| R-HSA-8939211 | ESR-mediated signaling | 0.929673 | 0.032 |
| R-HSA-212436 | Generic Transcription Pathway | 0.936384 | 0.029 |
| R-HSA-5663205 | Infectious disease | 0.943075 | 0.025 |
| R-HSA-74160 | Gene expression (Transcription) | 0.954556 | 0.020 |
| R-HSA-2262752 | Cellular responses to stress | 0.958657 | 0.018 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.961209 | 0.017 |
| R-HSA-1483257 | Phospholipid metabolism | 0.961598 | 0.017 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.969768 | 0.013 |
| R-HSA-8957322 | Metabolism of steroids | 0.971646 | 0.012 |
| R-HSA-1474244 | Extracellular matrix organization | 0.973651 | 0.012 |
| R-HSA-168256 | Immune System | 0.973987 | 0.011 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.981161 | 0.008 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.981358 | 0.008 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.982203 | 0.008 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.985962 | 0.006 |
| R-HSA-9709957 | Sensory Perception | 0.999170 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999986 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
PIM3 |
0.840 | 0.288 | -3 | 0.895 |
NDR2 |
0.839 | 0.263 | -3 | 0.878 |
RSK2 |
0.835 | 0.268 | -3 | 0.867 |
CDKL5 |
0.833 | 0.261 | -3 | 0.887 |
COT |
0.832 | 0.090 | 2 | 0.799 |
CDC7 |
0.832 | 0.127 | 1 | 0.786 |
AURC |
0.831 | 0.250 | -2 | 0.744 |
CDKL1 |
0.831 | 0.277 | -3 | 0.884 |
NDR1 |
0.831 | 0.235 | -3 | 0.878 |
RSK3 |
0.829 | 0.266 | -3 | 0.867 |
P90RSK |
0.829 | 0.247 | -3 | 0.873 |
PIM1 |
0.829 | 0.280 | -3 | 0.867 |
PRKD1 |
0.828 | 0.209 | -3 | 0.893 |
CLK3 |
0.826 | 0.155 | 1 | 0.725 |
SRPK1 |
0.826 | 0.223 | -3 | 0.865 |
PKACB |
0.825 | 0.280 | -2 | 0.742 |
HIPK4 |
0.825 | 0.189 | 1 | 0.695 |
PKACG |
0.825 | 0.221 | -2 | 0.783 |
MTOR |
0.825 | 0.174 | 1 | 0.708 |
SKMLCK |
0.824 | 0.209 | -2 | 0.890 |
ICK |
0.824 | 0.246 | -3 | 0.897 |
CAMK1B |
0.824 | 0.191 | -3 | 0.876 |
MOS |
0.823 | 0.110 | 1 | 0.824 |
NUAK2 |
0.823 | 0.193 | -3 | 0.874 |
NIM1 |
0.823 | 0.282 | 3 | 0.859 |
RSK4 |
0.822 | 0.251 | -3 | 0.849 |
MARK4 |
0.822 | 0.189 | 4 | 0.768 |
PRKD2 |
0.822 | 0.202 | -3 | 0.848 |
LATS2 |
0.821 | 0.133 | -5 | 0.701 |
MST4 |
0.821 | 0.207 | 2 | 0.814 |
MSK2 |
0.821 | 0.230 | -3 | 0.873 |
P70S6KB |
0.820 | 0.209 | -3 | 0.865 |
PKN3 |
0.820 | 0.156 | -3 | 0.869 |
AMPKA1 |
0.820 | 0.175 | -3 | 0.876 |
SGK3 |
0.820 | 0.283 | -3 | 0.867 |
WNK1 |
0.819 | 0.119 | -2 | 0.885 |
CAMLCK |
0.819 | 0.214 | -2 | 0.888 |
PRKX |
0.819 | 0.263 | -3 | 0.800 |
IKKB |
0.819 | -0.031 | -2 | 0.752 |
MSK1 |
0.818 | 0.238 | -3 | 0.873 |
RAF1 |
0.818 | 0.025 | 1 | 0.762 |
DYRK2 |
0.818 | 0.141 | 1 | 0.636 |
PRPK |
0.818 | -0.018 | -1 | 0.690 |
PAK1 |
0.818 | 0.184 | -2 | 0.858 |
ERK5 |
0.817 | 0.077 | 1 | 0.770 |
AMPKA2 |
0.817 | 0.184 | -3 | 0.867 |
AKT2 |
0.817 | 0.278 | -3 | 0.814 |
QSK |
0.817 | 0.228 | 4 | 0.748 |
NLK |
0.817 | 0.056 | 1 | 0.745 |
TSSK1 |
0.817 | 0.167 | -3 | 0.878 |
PKCD |
0.817 | 0.186 | 2 | 0.715 |
MAPKAPK2 |
0.817 | 0.176 | -3 | 0.850 |
AURB |
0.816 | 0.209 | -2 | 0.743 |
DAPK2 |
0.816 | 0.222 | -3 | 0.880 |
HUNK |
0.816 | 0.045 | 2 | 0.761 |
PKN2 |
0.816 | 0.150 | -3 | 0.864 |
ATR |
0.816 | 0.067 | 1 | 0.770 |
HIPK1 |
0.816 | 0.205 | 1 | 0.656 |
SRPK2 |
0.816 | 0.208 | -3 | 0.820 |
MAPKAPK3 |
0.815 | 0.138 | -3 | 0.869 |
CLK2 |
0.814 | 0.253 | -3 | 0.847 |
PIM2 |
0.814 | 0.268 | -3 | 0.848 |
CLK4 |
0.814 | 0.221 | -3 | 0.852 |
PAK3 |
0.813 | 0.150 | -2 | 0.849 |
NIK |
0.813 | 0.146 | -3 | 0.860 |
PDHK4 |
0.813 | -0.054 | 1 | 0.769 |
CAMK2D |
0.813 | 0.115 | -3 | 0.870 |
SIK |
0.813 | 0.231 | -3 | 0.841 |
HIPK2 |
0.813 | 0.163 | 1 | 0.555 |
PKACA |
0.813 | 0.258 | -2 | 0.696 |
TBK1 |
0.812 | -0.064 | 1 | 0.671 |
SRPK3 |
0.812 | 0.194 | -3 | 0.842 |
PDHK1 |
0.812 | -0.005 | 1 | 0.764 |
MAK |
0.812 | 0.292 | -2 | 0.779 |
MNK2 |
0.811 | 0.152 | -2 | 0.830 |
DSTYK |
0.811 | -0.044 | 2 | 0.803 |
GRK1 |
0.811 | 0.045 | -2 | 0.821 |
PKCA |
0.810 | 0.192 | 2 | 0.659 |
AURA |
0.810 | 0.186 | -2 | 0.730 |
GCN2 |
0.810 | -0.099 | 2 | 0.767 |
PRKD3 |
0.810 | 0.189 | -3 | 0.844 |
PKG2 |
0.810 | 0.183 | -2 | 0.736 |
RIPK3 |
0.810 | -0.006 | 3 | 0.799 |
ULK2 |
0.809 | -0.073 | 2 | 0.741 |
CLK1 |
0.809 | 0.202 | -3 | 0.830 |
AKT1 |
0.809 | 0.271 | -3 | 0.826 |
KIS |
0.809 | 0.037 | 1 | 0.630 |
MELK |
0.809 | 0.146 | -3 | 0.860 |
QIK |
0.809 | 0.163 | -3 | 0.859 |
NEK6 |
0.809 | -0.002 | -2 | 0.815 |
CDK18 |
0.808 | 0.111 | 1 | 0.555 |
DYRK1A |
0.808 | 0.183 | 1 | 0.652 |
PAK6 |
0.808 | 0.142 | -2 | 0.803 |
BCKDK |
0.808 | -0.012 | -1 | 0.656 |
PAK2 |
0.808 | 0.147 | -2 | 0.848 |
BMPR2 |
0.808 | -0.110 | -2 | 0.853 |
TGFBR2 |
0.808 | -0.004 | -2 | 0.761 |
LATS1 |
0.807 | 0.165 | -3 | 0.881 |
CAMK2G |
0.807 | -0.068 | 2 | 0.759 |
NUAK1 |
0.807 | 0.142 | -3 | 0.848 |
PKCG |
0.807 | 0.145 | 2 | 0.668 |
DYRK3 |
0.807 | 0.210 | 1 | 0.659 |
PKCB |
0.807 | 0.143 | 2 | 0.664 |
TSSK2 |
0.807 | 0.052 | -5 | 0.762 |
RIPK1 |
0.807 | 0.037 | 1 | 0.735 |
WNK3 |
0.806 | -0.042 | 1 | 0.735 |
IKKE |
0.806 | -0.103 | 1 | 0.661 |
CDK7 |
0.806 | 0.053 | 1 | 0.612 |
IKKA |
0.805 | -0.003 | -2 | 0.729 |
MNK1 |
0.805 | 0.130 | -2 | 0.835 |
CAMK4 |
0.805 | 0.078 | -3 | 0.850 |
MASTL |
0.805 | 0.009 | -2 | 0.797 |
MYLK4 |
0.804 | 0.164 | -2 | 0.836 |
HIPK3 |
0.804 | 0.167 | 1 | 0.650 |
CDK19 |
0.804 | 0.048 | 1 | 0.565 |
GRK5 |
0.804 | -0.096 | -3 | 0.794 |
DCAMKL1 |
0.803 | 0.211 | -3 | 0.851 |
CDK8 |
0.803 | 0.030 | 1 | 0.595 |
BRSK1 |
0.803 | 0.108 | -3 | 0.863 |
CDK5 |
0.803 | 0.105 | 1 | 0.631 |
DYRK4 |
0.803 | 0.116 | 1 | 0.568 |
IRE1 |
0.803 | 0.022 | 1 | 0.720 |
NEK7 |
0.803 | -0.100 | -3 | 0.788 |
AKT3 |
0.803 | 0.278 | -3 | 0.789 |
CDK14 |
0.803 | 0.135 | 1 | 0.594 |
PKCZ |
0.802 | 0.121 | 2 | 0.716 |
MARK3 |
0.802 | 0.126 | 4 | 0.692 |
CAMK2B |
0.802 | 0.077 | 2 | 0.732 |
CHAK2 |
0.802 | -0.040 | -1 | 0.656 |
SGK1 |
0.801 | 0.286 | -3 | 0.780 |
MPSK1 |
0.801 | 0.301 | 1 | 0.795 |
MLK1 |
0.801 | -0.106 | 2 | 0.751 |
P70S6K |
0.801 | 0.199 | -3 | 0.831 |
JNK2 |
0.801 | 0.067 | 1 | 0.555 |
CAMK2A |
0.801 | 0.085 | 2 | 0.739 |
FAM20C |
0.801 | 0.024 | 2 | 0.548 |
MARK2 |
0.800 | 0.115 | 4 | 0.669 |
DYRK1B |
0.800 | 0.131 | 1 | 0.587 |
BRSK2 |
0.800 | 0.070 | -3 | 0.856 |
GRK6 |
0.799 | -0.071 | 1 | 0.747 |
CDK13 |
0.799 | 0.043 | 1 | 0.585 |
NEK9 |
0.798 | -0.041 | 2 | 0.784 |
MOK |
0.798 | 0.255 | 1 | 0.691 |
PKCH |
0.798 | 0.096 | 2 | 0.660 |
JNK3 |
0.797 | 0.040 | 1 | 0.585 |
DNAPK |
0.797 | 0.083 | 1 | 0.661 |
PHKG1 |
0.797 | 0.059 | -3 | 0.869 |
P38A |
0.797 | 0.072 | 1 | 0.652 |
ATM |
0.797 | -0.004 | 1 | 0.716 |
CDK12 |
0.797 | 0.061 | 1 | 0.554 |
WNK4 |
0.797 | 0.113 | -2 | 0.874 |
CHK1 |
0.796 | 0.092 | -3 | 0.856 |
PKCT |
0.796 | 0.162 | 2 | 0.668 |
MARK1 |
0.796 | 0.109 | 4 | 0.717 |
BMPR1B |
0.796 | 0.017 | 1 | 0.719 |
PKR |
0.796 | 0.091 | 1 | 0.766 |
ULK1 |
0.796 | -0.161 | -3 | 0.733 |
DLK |
0.796 | -0.105 | 1 | 0.735 |
MLK2 |
0.795 | -0.049 | 2 | 0.755 |
CAMK1G |
0.795 | 0.134 | -3 | 0.837 |
CDK10 |
0.795 | 0.117 | 1 | 0.582 |
GRK7 |
0.794 | 0.063 | 1 | 0.686 |
CDK9 |
0.794 | 0.044 | 1 | 0.595 |
GRK4 |
0.794 | -0.119 | -2 | 0.824 |
ANKRD3 |
0.793 | -0.109 | 1 | 0.787 |
CDK17 |
0.793 | 0.058 | 1 | 0.495 |
CAMK1D |
0.793 | 0.181 | -3 | 0.809 |
MAPKAPK5 |
0.793 | 0.082 | -3 | 0.850 |
P38B |
0.793 | 0.052 | 1 | 0.585 |
TTBK2 |
0.793 | -0.122 | 2 | 0.673 |
PAK5 |
0.793 | 0.144 | -2 | 0.746 |
ERK1 |
0.793 | 0.037 | 1 | 0.578 |
VRK2 |
0.793 | 0.046 | 1 | 0.796 |
PLK4 |
0.792 | 0.046 | 2 | 0.620 |
P38G |
0.792 | 0.041 | 1 | 0.488 |
DAPK3 |
0.792 | 0.221 | -3 | 0.863 |
IRE2 |
0.791 | -0.023 | 2 | 0.703 |
NEK2 |
0.791 | -0.014 | 2 | 0.754 |
CDK1 |
0.791 | 0.030 | 1 | 0.558 |
PKCI |
0.790 | 0.131 | 2 | 0.692 |
SNRK |
0.790 | -0.019 | 2 | 0.654 |
MLK3 |
0.790 | -0.071 | 2 | 0.675 |
MEK1 |
0.790 | -0.041 | 2 | 0.783 |
SMMLCK |
0.789 | 0.163 | -3 | 0.868 |
PAK4 |
0.789 | 0.134 | -2 | 0.751 |
PKCE |
0.789 | 0.160 | 2 | 0.656 |
SMG1 |
0.788 | -0.035 | 1 | 0.733 |
TGFBR1 |
0.788 | -0.038 | -2 | 0.752 |
CDK16 |
0.788 | 0.063 | 1 | 0.516 |
MRCKB |
0.787 | 0.228 | -3 | 0.829 |
ALK4 |
0.787 | -0.086 | -2 | 0.788 |
ROCK2 |
0.787 | 0.245 | -3 | 0.866 |
SSTK |
0.787 | 0.025 | 4 | 0.744 |
DAPK1 |
0.787 | 0.204 | -3 | 0.858 |
PLK1 |
0.786 | -0.120 | -2 | 0.762 |
PASK |
0.786 | 0.086 | -3 | 0.894 |
SBK |
0.785 | 0.234 | -3 | 0.731 |
PKN1 |
0.785 | 0.156 | -3 | 0.833 |
MST3 |
0.785 | 0.099 | 2 | 0.776 |
DCAMKL2 |
0.785 | 0.083 | -3 | 0.849 |
YSK4 |
0.784 | -0.091 | 1 | 0.695 |
ERK2 |
0.784 | -0.010 | 1 | 0.593 |
CDK3 |
0.784 | 0.050 | 1 | 0.519 |
ALK2 |
0.784 | -0.042 | -2 | 0.772 |
P38D |
0.784 | 0.040 | 1 | 0.532 |
CHK2 |
0.784 | 0.192 | -3 | 0.775 |
PBK |
0.783 | 0.281 | 1 | 0.854 |
GAK |
0.783 | 0.227 | 1 | 0.872 |
IRAK4 |
0.783 | -0.004 | 1 | 0.731 |
MLK4 |
0.783 | -0.109 | 2 | 0.671 |
CAMK1A |
0.783 | 0.186 | -3 | 0.782 |
PHKG2 |
0.782 | 0.058 | -3 | 0.823 |
BRAF |
0.782 | -0.028 | -4 | 0.792 |
ACVR2A |
0.782 | -0.072 | -2 | 0.750 |
NEK5 |
0.782 | 0.023 | 1 | 0.766 |
TLK2 |
0.782 | -0.059 | 1 | 0.697 |
DRAK1 |
0.782 | -0.045 | 1 | 0.681 |
MEKK1 |
0.782 | 0.005 | 1 | 0.738 |
CK1E |
0.782 | -0.013 | -3 | 0.500 |
CHAK1 |
0.781 | -0.116 | 2 | 0.712 |
MRCKA |
0.781 | 0.196 | -3 | 0.839 |
MEKK2 |
0.781 | 0.004 | 2 | 0.753 |
MEK5 |
0.780 | -0.063 | 2 | 0.771 |
CRIK |
0.780 | 0.255 | -3 | 0.833 |
MEKK3 |
0.780 | -0.091 | 1 | 0.722 |
PRP4 |
0.779 | -0.019 | -3 | 0.700 |
ACVR2B |
0.779 | -0.083 | -2 | 0.761 |
PERK |
0.779 | -0.083 | -2 | 0.807 |
DMPK1 |
0.779 | 0.251 | -3 | 0.826 |
CDK2 |
0.779 | -0.020 | 1 | 0.635 |
PKG1 |
0.779 | 0.172 | -2 | 0.667 |
PDK1 |
0.778 | 0.107 | 1 | 0.720 |
TAO3 |
0.777 | 0.065 | 1 | 0.710 |
PLK3 |
0.777 | -0.129 | 2 | 0.727 |
LKB1 |
0.777 | 0.050 | -3 | 0.788 |
ZAK |
0.777 | -0.077 | 1 | 0.695 |
MEKK6 |
0.776 | 0.128 | 1 | 0.713 |
GRK2 |
0.775 | -0.086 | -2 | 0.718 |
BMPR1A |
0.775 | -0.024 | 1 | 0.702 |
CK1G1 |
0.775 | -0.017 | -3 | 0.488 |
BUB1 |
0.775 | 0.118 | -5 | 0.736 |
PINK1 |
0.775 | -0.089 | 1 | 0.755 |
HRI |
0.774 | -0.131 | -2 | 0.816 |
CDK4 |
0.774 | 0.048 | 1 | 0.544 |
ROCK1 |
0.773 | 0.220 | -3 | 0.840 |
GSK3B |
0.773 | -0.006 | 4 | 0.401 |
JNK1 |
0.772 | 0.012 | 1 | 0.543 |
CDK6 |
0.772 | 0.043 | 1 | 0.584 |
CAMKK1 |
0.771 | -0.066 | -2 | 0.767 |
IRAK1 |
0.771 | -0.128 | -1 | 0.584 |
CAMKK2 |
0.770 | -0.024 | -2 | 0.763 |
MAP3K15 |
0.770 | 0.091 | 1 | 0.686 |
CK1D |
0.770 | -0.019 | -3 | 0.451 |
TNIK |
0.770 | 0.113 | 3 | 0.893 |
GSK3A |
0.770 | 0.008 | 4 | 0.408 |
ERK7 |
0.770 | 0.005 | 2 | 0.504 |
NEK8 |
0.770 | -0.084 | 2 | 0.758 |
GCK |
0.769 | 0.067 | 1 | 0.707 |
NEK11 |
0.769 | -0.038 | 1 | 0.701 |
HGK |
0.769 | 0.077 | 3 | 0.892 |
NEK4 |
0.769 | 0.005 | 1 | 0.720 |
TLK1 |
0.769 | -0.146 | -2 | 0.784 |
HPK1 |
0.769 | 0.092 | 1 | 0.692 |
CK2A2 |
0.769 | 0.022 | 1 | 0.699 |
CK1A2 |
0.769 | -0.022 | -3 | 0.457 |
MINK |
0.769 | 0.084 | 1 | 0.709 |
TAO2 |
0.768 | -0.006 | 2 | 0.768 |
KHS1 |
0.768 | 0.128 | 1 | 0.696 |
NEK1 |
0.767 | 0.062 | 1 | 0.734 |
KHS2 |
0.766 | 0.130 | 1 | 0.701 |
LRRK2 |
0.766 | 0.019 | 2 | 0.788 |
TTBK1 |
0.765 | -0.162 | 2 | 0.597 |
GRK3 |
0.765 | -0.071 | -2 | 0.683 |
EEF2K |
0.764 | -0.015 | 3 | 0.867 |
YSK1 |
0.763 | 0.093 | 2 | 0.759 |
LOK |
0.763 | 0.014 | -2 | 0.764 |
BIKE |
0.761 | 0.219 | 1 | 0.843 |
MST2 |
0.761 | -0.056 | 1 | 0.729 |
TAK1 |
0.761 | -0.077 | 1 | 0.727 |
VRK1 |
0.760 | -0.059 | 2 | 0.786 |
NEK3 |
0.759 | 0.058 | 1 | 0.691 |
HASPIN |
0.758 | 0.033 | -1 | 0.608 |
CK2A1 |
0.757 | -0.003 | 1 | 0.674 |
STK33 |
0.757 | -0.093 | 2 | 0.589 |
MEK2 |
0.756 | -0.068 | 2 | 0.766 |
AAK1 |
0.755 | 0.268 | 1 | 0.779 |
RIPK2 |
0.753 | -0.151 | 1 | 0.669 |
PLK2 |
0.752 | -0.091 | -3 | 0.696 |
PDHK3_TYR |
0.752 | 0.136 | 4 | 0.839 |
SLK |
0.752 | -0.078 | -2 | 0.708 |
MST1 |
0.750 | -0.099 | 1 | 0.709 |
MYO3B |
0.750 | 0.081 | 2 | 0.760 |
PKMYT1_TYR |
0.749 | 0.253 | 3 | 0.890 |
MAP2K4_TYR |
0.748 | 0.211 | -1 | 0.721 |
YANK3 |
0.746 | -0.029 | 2 | 0.398 |
LIMK2_TYR |
0.745 | 0.152 | -3 | 0.850 |
ASK1 |
0.745 | -0.015 | 1 | 0.675 |
TTK |
0.745 | -0.037 | -2 | 0.784 |
TESK1_TYR |
0.744 | 0.038 | 3 | 0.925 |
OSR1 |
0.744 | -0.049 | 2 | 0.757 |
MAP2K6_TYR |
0.741 | 0.035 | -1 | 0.706 |
MYO3A |
0.740 | 0.020 | 1 | 0.687 |
PDHK4_TYR |
0.740 | 0.004 | 2 | 0.818 |
MAP2K7_TYR |
0.739 | -0.020 | 2 | 0.800 |
TAO1 |
0.738 | -0.031 | 1 | 0.643 |
PINK1_TYR |
0.736 | -0.034 | 1 | 0.759 |
BMPR2_TYR |
0.735 | -0.036 | -1 | 0.691 |
PDHK1_TYR |
0.735 | -0.069 | -1 | 0.693 |
LIMK1_TYR |
0.733 | 0.011 | 2 | 0.786 |
ALPHAK3 |
0.733 | -0.111 | -1 | 0.597 |
CK1A |
0.732 | -0.053 | -3 | 0.364 |
EPHA6 |
0.731 | -0.065 | -1 | 0.628 |
EPHB4 |
0.729 | -0.069 | -1 | 0.605 |
TNK2 |
0.729 | 0.034 | 3 | 0.778 |
FGR |
0.728 | 0.002 | 1 | 0.824 |
RET |
0.728 | -0.123 | 1 | 0.724 |
ROS1 |
0.728 | -0.054 | 3 | 0.829 |
TYK2 |
0.728 | -0.067 | 1 | 0.727 |
YES1 |
0.727 | -0.020 | -1 | 0.635 |
TXK |
0.727 | -0.017 | 1 | 0.792 |
TNNI3K_TYR |
0.727 | 0.057 | 1 | 0.747 |
ABL2 |
0.726 | -0.036 | -1 | 0.597 |
MST1R |
0.726 | -0.106 | 3 | 0.844 |
TYRO3 |
0.726 | -0.120 | 3 | 0.843 |
BLK |
0.725 | 0.046 | -1 | 0.612 |
ABL1 |
0.724 | -0.037 | -1 | 0.595 |
JAK2 |
0.724 | -0.102 | 1 | 0.720 |
TNK1 |
0.724 | 0.015 | 3 | 0.830 |
LCK |
0.724 | 0.016 | -1 | 0.598 |
STLK3 |
0.723 | -0.156 | 1 | 0.664 |
HCK |
0.722 | -0.051 | -1 | 0.601 |
DDR1 |
0.722 | -0.134 | 4 | 0.744 |
FER |
0.721 | -0.131 | 1 | 0.810 |
ITK |
0.721 | -0.076 | -1 | 0.577 |
CSF1R |
0.720 | -0.138 | 3 | 0.824 |
JAK3 |
0.719 | -0.132 | 1 | 0.704 |
NEK10_TYR |
0.718 | -0.024 | 1 | 0.592 |
JAK1 |
0.717 | -0.017 | 1 | 0.675 |
EPHB3 |
0.717 | -0.106 | -1 | 0.580 |
SRMS |
0.716 | -0.142 | 1 | 0.781 |
EPHA4 |
0.716 | -0.115 | 2 | 0.718 |
AXL |
0.715 | -0.111 | 3 | 0.811 |
INSRR |
0.715 | -0.158 | 3 | 0.805 |
MERTK |
0.714 | -0.109 | 3 | 0.814 |
BMX |
0.714 | -0.093 | -1 | 0.509 |
EPHB1 |
0.713 | -0.179 | 1 | 0.772 |
FYN |
0.713 | -0.025 | -1 | 0.583 |
EPHB2 |
0.713 | -0.133 | -1 | 0.575 |
PDGFRB |
0.713 | -0.169 | 3 | 0.842 |
FGFR2 |
0.712 | -0.182 | 3 | 0.834 |
KDR |
0.711 | -0.126 | 3 | 0.791 |
WEE1_TYR |
0.711 | -0.082 | -1 | 0.566 |
BTK |
0.709 | -0.182 | -1 | 0.546 |
FLT3 |
0.709 | -0.177 | 3 | 0.834 |
TEK |
0.709 | -0.177 | 3 | 0.784 |
CK1G3 |
0.709 | -0.069 | -3 | 0.321 |
KIT |
0.709 | -0.186 | 3 | 0.822 |
TEC |
0.708 | -0.144 | -1 | 0.531 |
EPHA1 |
0.707 | -0.120 | 3 | 0.792 |
DDR2 |
0.707 | -0.051 | 3 | 0.773 |
MET |
0.707 | -0.152 | 3 | 0.815 |
FGFR1 |
0.706 | -0.185 | 3 | 0.803 |
LTK |
0.706 | -0.142 | 3 | 0.776 |
PTK6 |
0.706 | -0.177 | -1 | 0.523 |
SRC |
0.706 | -0.043 | -1 | 0.592 |
EPHA7 |
0.705 | -0.135 | 2 | 0.717 |
YANK2 |
0.705 | -0.077 | 2 | 0.404 |
EPHA3 |
0.704 | -0.157 | 2 | 0.699 |
PDGFRA |
0.704 | -0.213 | 3 | 0.835 |
ALK |
0.704 | -0.179 | 3 | 0.763 |
PTK2B |
0.704 | -0.105 | -1 | 0.565 |
LYN |
0.704 | -0.098 | 3 | 0.750 |
NTRK1 |
0.702 | -0.205 | -1 | 0.598 |
FRK |
0.701 | -0.160 | -1 | 0.604 |
FLT1 |
0.701 | -0.185 | -1 | 0.605 |
ERBB2 |
0.700 | -0.189 | 1 | 0.684 |
FGFR3 |
0.699 | -0.206 | 3 | 0.805 |
NTRK3 |
0.699 | -0.151 | -1 | 0.555 |
INSR |
0.698 | -0.180 | 3 | 0.782 |
EPHA5 |
0.697 | -0.148 | 2 | 0.703 |
NTRK2 |
0.696 | -0.224 | 3 | 0.788 |
FLT4 |
0.696 | -0.210 | 3 | 0.784 |
MATK |
0.696 | -0.149 | -1 | 0.544 |
PTK2 |
0.695 | -0.078 | -1 | 0.574 |
EPHA8 |
0.695 | -0.147 | -1 | 0.567 |
CSK |
0.694 | -0.163 | 2 | 0.723 |
EGFR |
0.693 | -0.136 | 1 | 0.602 |
FGFR4 |
0.690 | -0.154 | -1 | 0.559 |
SYK |
0.689 | -0.117 | -1 | 0.550 |
IGF1R |
0.684 | -0.177 | 3 | 0.727 |
EPHA2 |
0.684 | -0.166 | -1 | 0.533 |
CK1G2 |
0.683 | -0.090 | -3 | 0.406 |
MUSK |
0.681 | -0.170 | 1 | 0.599 |
ERBB4 |
0.680 | -0.128 | 1 | 0.620 |
ZAP70 |
0.674 | -0.084 | -1 | 0.509 |
FES |
0.673 | -0.179 | -1 | 0.495 |