Motif 866 (n=129)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| B2RTY4 | MYO9A | S2293 | ochoa | Unconventional myosin-IXa (Unconventional myosin-9a) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating it's GTPase activity in neurons. Required for the regulation of neurite branching and motor neuron axon guidance (By similarity). {ECO:0000250|UniProtKB:Q8C170, ECO:0000250|UniProtKB:Q9Z1N3}. |
| H3BRN7 | None | S23 | ochoa | Uncharacterized protein | None |
| O00515 | LAD1 | S497 | ochoa | Ladinin-1 (Lad-1) (Linear IgA disease antigen) (LADA) | Anchoring filament protein which is a component of the basement membrane zone. {ECO:0000250}. |
| O00559 | EBAG9 | S50 | ochoa | Receptor-binding cancer antigen expressed on SiSo cells (Cancer-associated surface antigen RCAS1) (Estrogen receptor-binding fragment-associated gene 9 protein) | May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases. {ECO:0000269|PubMed:12054692, ECO:0000269|PubMed:12138241, ECO:0000269|PubMed:12672804}. |
| O14617 | AP3D1 | S685 | ochoa | AP-3 complex subunit delta-1 (AP-3 complex subunit delta) (Adaptor-related protein complex 3 subunit delta-1) (Delta-adaptin) | Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Involved in process of CD8+ T-cell and NK cell degranulation (PubMed:26744459). In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity). {ECO:0000250|UniProtKB:O54774, ECO:0000269|PubMed:26744459}. |
| O14646 | CHD1 | S1545 | ochoa | Chromodomain-helicase-DNA-binding protein 1 (CHD-1) (EC 3.6.4.-) (ATP-dependent helicase CHD1) | ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3 (PubMed:18042460, PubMed:28866611). Required for maintaining open chromatin and pluripotency in embryonic stem cells (By similarity). {ECO:0000250|UniProtKB:P40201, ECO:0000269|PubMed:18042460, ECO:0000269|PubMed:28866611}. |
| O15173 | PGRMC2 | S94 | ochoa | Membrane-associated progesterone receptor component 2 (Progesterone membrane-binding protein) (Steroid receptor protein DG6) | Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity). May serve as a universal non-classical progesterone receptor in the uterus (Probable). Intracellular heme chaperone required for delivery of labile, or signaling heme, to the nucleus (By similarity). Plays a role in adipocyte function and systemic glucose homeostasis (PubMed:28111073). In brown fat, which has a high demand for heme, delivery of labile heme in the nucleus regulates the activity of heme-responsive transcriptional repressors such as NR1D1 and BACH1 (By similarity). {ECO:0000250|UniProtKB:Q80UU9, ECO:0000269|PubMed:28111073, ECO:0000305|PubMed:28396637}. |
| O15541 | RNF113A | S47 | ochoa | E3 ubiquitin-protein ligase RNF113A (EC 2.3.2.27) (Cwc24 homolog) (RING finger protein 113A) (Zinc finger protein 183) | Required for pre-mRNA splicing as component of the spliceosome (PubMed:29360106, PubMed:29361316). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). E3 ubiquitin-protein ligase that catalyzes the transfer of ubiquitin onto target proteins (PubMed:28978524, PubMed:29144457). Catalyzes polyubiquitination of SNRNP200/BRR2 with non-canonical 'Lys-63'-linked polyubiquitin chains (PubMed:29144457). Plays a role in DNA repair via its role in the synthesis of 'Lys-63'-linked polyubiquitin chains that recruit ALKBH3 and the ASCC complex to sites of DNA damage by alkylating agents (PubMed:29144457). Ubiquitinates CXCR4, leading to its degradation, and thereby contributes to the termination of CXCR4 signaling (PubMed:28978524). {ECO:0000269|PubMed:28978524, ECO:0000269|PubMed:29144457, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000305|PubMed:33509932}. |
| O43520 | ATP8B1 | S1222 | ochoa | Phospholipid-transporting ATPase IC (EC 7.6.2.1) (ATPase class I type 8B member 1) (Familial intrahepatic cholestasis type 1) (P4-ATPase flippase complex alpha subunit ATP8B1) | Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of phospholipids, in particular phosphatidylcholines (PC), from the outer to the inner leaflet of the plasma membrane (PubMed:17948906, PubMed:25315773). May participate in the establishment of the canalicular membrane integrity by ensuring asymmetric distribution of phospholipids in the canicular membrane (By similarity). Thus may have a role in the regulation of bile acids transport into the canaliculus, uptake of bile acids from intestinal contents into intestinal mucosa or both and protect hepatocytes from bile salts (By similarity). Involved in the microvillus formation in polarized epithelial cells; the function seems to be independent from its flippase activity (PubMed:20512993). Participates in correct apical membrane localization of CDC42, CFTR and SLC10A2 (PubMed:25239307, PubMed:27301931). Enables CDC42 clustering at the apical membrane during enterocyte polarization through the interaction between CDC42 polybasic region and negatively charged membrane lipids provided by ATP8B1 (By similarity). Together with TMEM30A is involved in uptake of the synthetic drug alkylphospholipid perifosine (PubMed:20510206). Required for the preservation of cochlear hair cells in the inner ear (By similarity). May act as cardiolipin transporter during inflammatory injury (By similarity). {ECO:0000250|UniProtKB:Q148W0, ECO:0000269|PubMed:17948906, ECO:0000269|PubMed:20510206, ECO:0000269|PubMed:20512993, ECO:0000269|PubMed:25239307, ECO:0000269|PubMed:27301931}. |
| O43847 | NRDC | S108 | ochoa | Nardilysin (EC 3.4.24.61) (N-arginine dibasic convertase) (NRD convertase) (NRD-C) (Nardilysin convertase) | Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. Is a critical activator of BACE1- and ADAM17-mediated pro-neuregulin ectodomain shedding, involved in the positive regulation of axonal maturation and myelination. Required for proper functioning of 2-oxoglutarate dehydrogenase (OGDH) (By similarity). {ECO:0000250|UniProtKB:Q8BHG1}. |
| O60565 | GREM1 | S76 | ochoa | Gremlin-1 (Cell proliferation-inducing gene 2 protein) (Cysteine knot superfamily 1, BMP antagonist 1) (DAN domain family member 2) (Down-regulated in Mos-transformed cells protein) (Increased in high glucose protein 2) (IHG-2) | Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner (By similarity). Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro) (PubMed:27036124). Acts as inhibitor of monocyte chemotaxis. Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed (By similarity). {ECO:0000250|UniProtKB:O35793, ECO:0000250|UniProtKB:O70326, ECO:0000269|PubMed:27036124}. |
| O75140 | DEPDC5 | S502 | ochoa | GATOR1 complex protein DEPDC5 (DEP domain-containing protein 5) | As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the mTORC1 pathway (PubMed:23723238, PubMed:25457612, PubMed:29590090, PubMed:29769719, PubMed:31548394, PubMed:35338845). In response to amino acid depletion, the GATOR1 complex has GTPase activating protein (GAP) activity and strongly increases GTP hydrolysis by RagA/RRAGA (or RagB/RRAGB) within heterodimeric Rag complexes, thereby turning them into their inactive GDP-bound form, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling (PubMed:23723238, PubMed:25457612, PubMed:29590090, PubMed:29769719, PubMed:35338845). In the presence of abundant amino acids, the GATOR1 complex is negatively regulated by GATOR2, the other GATOR subcomplex, in this amino acid-sensing branch of the TORC1 pathway (PubMed:23723238, PubMed:25457612, PubMed:29769719). Within the GATOR1 complex, DEPDC5 mediates direct interaction with the nucleotide-binding pocket of small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD) and coordinates their nucleotide loading states by promoting RagA/RRAGA or RagB/RRAGB into their GDP-binding state and RagC/RRAGC or RagD/RRAGD into their GTP-binding state (PubMed:29590090, PubMed:35338845). However, it does not execute the GAP activity, which is mediated by NPRL2 (PubMed:29590090). {ECO:0000269|PubMed:23723238, ECO:0000269|PubMed:25457612, ECO:0000269|PubMed:29590090, ECO:0000269|PubMed:29769719, ECO:0000269|PubMed:31548394, ECO:0000269|PubMed:35338845}. |
| O75533 | SF3B1 | S286 | ochoa | Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B1 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). {ECO:0000250|UniProtKB:Q99NB9, ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}. |
| O94915 | FRYL | S1970 | ochoa | Protein furry homolog-like (ALL1-fused gene from chromosome 4p12 protein) | Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching (By similarity). May function as a transcriptional activator. {ECO:0000250, ECO:0000269|PubMed:16061630}. |
| O94915 | FRYL | S1971 | ochoa | Protein furry homolog-like (ALL1-fused gene from chromosome 4p12 protein) | Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching (By similarity). May function as a transcriptional activator. {ECO:0000250, ECO:0000269|PubMed:16061630}. |
| O94989 | ARHGEF15 | S41 | ochoa | Rho guanine nucleotide exchange factor 15 (Ephexin-5) (E5) (Vsm-RhoGEF) | Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synapse development by suppressing the synapse-promoting activity of EPHB2. {ECO:0000269|PubMed:12775584}. |
| O95232 | LUC7L3 | S115 | ochoa | Luc7-like protein 3 (Cisplatin resistance-associated-overexpressed protein) (Luc7A) (Okadaic acid-inducible phosphoprotein OA48-18) (cAMP regulatory element-associated protein 1) (CRE-associated protein 1) (CREAP-1) | Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing. {ECO:0000269|PubMed:16462885}. |
| O96013 | PAK4 | S195 | ochoa | Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4) | Serine/threonine-protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell adhesion turnover, cell migration, growth, proliferation or cell survival (PubMed:26598620). Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN. Promotes kinase-independent stabilization of RHOU, thereby contributing to focal adhesion disassembly during cell migration (PubMed:26598620). {ECO:0000269|PubMed:11278822, ECO:0000269|PubMed:11313478, ECO:0000269|PubMed:14560027, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:20507994, ECO:0000269|PubMed:20631255, ECO:0000269|PubMed:20805321, ECO:0000269|PubMed:26598620, ECO:0000269|PubMed:26607847}. |
| P04049 | RAF1 | Y232 | ochoa | RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) | Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}. |
| P04150 | NR3C1 | S403 | ochoa | Glucocorticoid receptor (GR) (Nuclear receptor subfamily 3 group C member 1) | Receptor for glucocorticoids (GC) (PubMed:27120390, PubMed:37478846). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors (PubMed:28139699). Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:25775514, ECO:0000269|PubMed:27120390, ECO:0000269|PubMed:28139699, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:9590696}.; FUNCTION: [Isoform Alpha]: Has transcriptional activation and repression activity (PubMed:11435610, PubMed:15769988, PubMed:15866175, PubMed:17635946, PubMed:19141540, PubMed:19248771, PubMed:20484466, PubMed:21664385, PubMed:23820903). Mediates glucocorticoid-induced apoptosis (PubMed:23303127). Promotes accurate chromosome segregation during mitosis (PubMed:25847991). May act as a tumor suppressor (PubMed:25847991). May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression (By similarity). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:11435610, ECO:0000269|PubMed:15769988, ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:17635946, ECO:0000269|PubMed:19141540, ECO:0000269|PubMed:19248771, ECO:0000269|PubMed:20484466, ECO:0000269|PubMed:21664385, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903, ECO:0000269|PubMed:25847991}.; FUNCTION: [Isoform Beta]: Acts as a dominant negative inhibitor of isoform Alpha (PubMed:20484466, PubMed:7769088, PubMed:8621628). Has intrinsic transcriptional activity independent of isoform Alpha when both isoforms are coexpressed (PubMed:19248771, PubMed:26711253). Loses this transcription modulator function on its own (PubMed:20484466). Has no hormone-binding activity (PubMed:8621628). May play a role in controlling glucose metabolism by maintaining insulin sensitivity (By similarity). Reduces hepatic gluconeogenesis through down-regulation of PEPCK in an isoform Alpha-dependent manner (PubMed:26711253). Directly regulates STAT1 expression in isoform Alpha-independent manner (PubMed:26711253). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:19248771, ECO:0000269|PubMed:20484466, ECO:0000269|PubMed:26711253, ECO:0000269|PubMed:7769088, ECO:0000269|PubMed:8621628}.; FUNCTION: [Isoform Alpha-2]: Has lower transcriptional activation activity than isoform Alpha. Exerts a dominant negative effect on isoform Alpha trans-repression mechanism (PubMed:20484466).; FUNCTION: [Isoform GR-P]: Increases activity of isoform Alpha. {ECO:0000269|PubMed:11358809}.; FUNCTION: [Isoform Alpha-B]: More effective than isoform Alpha in transcriptional activation, but not repression activity. {ECO:0000269|PubMed:11435610, ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform 10]: Has transcriptional activation activity. {ECO:0000269|PubMed:20484466}.; FUNCTION: [Isoform Alpha-C1]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-C2]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-C3]: Has highest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127). Mediates glucocorticoid-induced apoptosis (PubMed:23303127, PubMed:23820903). {ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903}.; FUNCTION: [Isoform Alpha-D1]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-D2]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-D3]: Has lowest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127). {ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903}. |
| P12270 | TPR | S631 | ochoa | Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:11952838, PubMed:22253824). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:21613532, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:9864356}. |
| P14859 | POU2F1 | S447 | ochoa | POU domain, class 2, transcription factor 1 (NF-A1) (Octamer-binding protein 1) (Oct-1) (Octamer-binding transcription factor 1) (OTF-1) | Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR. {ECO:0000269|PubMed:10480874, ECO:0000269|PubMed:1684878, ECO:0000269|PubMed:7859290}.; FUNCTION: (Microbial infection) In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000305|PubMed:12826401}. |
| P14923 | JUP | S98 | ochoa | Junction plakoglobin (Catenin gamma) (Desmoplakin III) (Desmoplakin-3) | Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity). {ECO:0000250}. |
| P16383 | GCFC2 | S429 | ochoa | Intron Large complex component GCFC2 (GC-rich sequence DNA-binding factor) (GC-rich sequence DNA-binding factor 2) (Transcription factor 9) (TCF-9) | Involved in pre-mRNA splicing through regulating spliceosome C complex formation (PubMed:24304693). May play a role during late-stage splicing events and turnover of excised introns (PubMed:24304693). {ECO:0000269|PubMed:24304693}. |
| P23588 | EIF4B | S433 | ochoa | Eukaryotic translation initiation factor 4B (eIF-4B) | Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. |
| P27338 | MAOB | S465 | ochoa | Amine oxidase [flavin-containing] B (EC 1.4.3.21) (EC 1.4.3.4) (Monoamine oxidase type B) (MAO-B) | Catalyzes the oxidative deamination of primary and some secondary amines such as neurotransmitters, and exogenous amines including the tertiary amine, neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), with concomitant reduction of oxygen to hydrogen peroxide and participates in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues (PubMed:11049757, PubMed:11134050, PubMed:20493079, PubMed:8316221, PubMed:8665924). Preferentially degrades benzylamine and phenylethylamine (PubMed:11049757, PubMed:11134050, PubMed:20493079, PubMed:8316221, PubMed:8665924). {ECO:0000269|PubMed:11049757, ECO:0000269|PubMed:11134050, ECO:0000269|PubMed:20493079, ECO:0000269|PubMed:8316221, ECO:0000269|PubMed:8665924}. |
| P33991 | MCM4 | S31 | ochoa | DNA replication licensing factor MCM4 (EC 3.6.4.12) (CDC21 homolog) (P1-CDC21) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:25661590, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:16899510, PubMed:25661590, PubMed:32453425, PubMed:9305914). {ECO:0000269|PubMed:16899510, ECO:0000269|PubMed:25661590, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9305914}. |
| P35568 | IRS1 | S374 | ochoa | Insulin receptor substrate 1 (IRS-1) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:19639489, ECO:0000269|PubMed:38625937, ECO:0000269|PubMed:7541045, ECO:0000269|PubMed:8265614}. |
| P40692 | MLH1 | S406 | ochoa|psp | DNA mismatch repair protein Mlh1 (MutL protein homolog 1) | Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma which plays a role in meiosis. {ECO:0000269|PubMed:16873062, ECO:0000269|PubMed:18206974, ECO:0000269|PubMed:20020535, ECO:0000269|PubMed:21120944, ECO:0000269|PubMed:39032648, ECO:0000269|PubMed:9311737}. |
| P41231 | P2RY2 | S355 | ochoa | P2Y purinoceptor 2 (P2Y2) (ATP receptor) (P2U purinoceptor 1) (P2U1) (P2U receptor 1) (Purinergic receptor) | Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP. |
| P43405 | SYK | S306 | ochoa | Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) (p72-Syk) | Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development (PubMed:12387735, PubMed:33782605). Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors phosphorylated by SYK include DEPTOR, VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK (PubMed:12456653, PubMed:15388330, PubMed:34634301, PubMed:8657103). Initially identified as essential in B-cell receptor (BCR) signaling, it is necessary for the maturation of B-cells most probably at the pro-B to pre-B transition (PubMed:12456653). Activated upon BCR engagement, it phosphorylates and activates BLNK an adapter linking the activated BCR to downstream signaling adapters and effectors. It also phosphorylates and activates PLCG1 and the PKC signaling pathway. It also phosphorylates BTK and regulates its activity in B-cell antigen receptor (BCR)-coupled signaling. In addition to its function downstream of BCR also plays a role in T-cell receptor signaling. Also plays a crucial role in the innate immune response to fungal, bacterial and viral pathogens. It is for instance activated by the membrane lectin CLEC7A. Upon stimulation by fungal proteins, CLEC7A together with SYK activates immune cells inducing the production of ROS. Also activates the inflammasome and NF-kappa-B-mediated transcription of chemokines and cytokines in presence of pathogens. Regulates neutrophil degranulation and phagocytosis through activation of the MAPK signaling cascade (By similarity). Required for the stimulation of neutrophil phagocytosis by IL15 (PubMed:15123770). Also mediates the activation of dendritic cells by cell necrosis stimuli. Also involved in mast cells activation. Involved in interleukin-3/IL3-mediated signaling pathway in basophils (By similarity). Also functions downstream of receptors mediating cell adhesion (PubMed:12387735). Relays for instance, integrin-mediated neutrophils and macrophages activation and P-selectin receptor/SELPG-mediated recruitment of leukocytes to inflammatory loci. Also plays a role in non-immune processes. It is for instance involved in vascular development where it may regulate blood and lymphatic vascular separation. It is also required for osteoclast development and function. Functions in the activation of platelets by collagen, mediating PLCG2 phosphorylation and activation. May be coupled to the collagen receptor by the ITAM domain-containing FCER1G. Also activated by the membrane lectin CLEC1B that is required for activation of platelets by PDPN/podoplanin. Involved in platelet adhesion being activated by ITGB3 engaged by fibrinogen. Together with CEACAM20, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a role in the intestinal immune response (By similarity). {ECO:0000250|UniProtKB:P48025, ECO:0000269|PubMed:12387735, ECO:0000269|PubMed:12456653, ECO:0000269|PubMed:15123770, ECO:0000269|PubMed:15388330, ECO:0000269|PubMed:19909739, ECO:0000269|PubMed:33782605, ECO:0000269|PubMed:34634301, ECO:0000269|PubMed:8657103, ECO:0000269|PubMed:9535867}. |
| P48730 | CSNK1D | S328 | ochoa | Casein kinase I isoform delta (CKI-delta) (CKId) (EC 2.7.11.1) (Tau-protein kinase CSNK1D) (EC 2.7.11.26) | Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. Phosphorylates NEDD9/HEF1 (By similarity). EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate. {ECO:0000250|UniProtKB:Q9DC28, ECO:0000269|PubMed:10606744, ECO:0000269|PubMed:12270943, ECO:0000269|PubMed:14761950, ECO:0000269|PubMed:16027726, ECO:0000269|PubMed:17562708, ECO:0000269|PubMed:17962809, ECO:0000269|PubMed:19043076, ECO:0000269|PubMed:20041275, ECO:0000269|PubMed:20048001, ECO:0000269|PubMed:20407760, ECO:0000269|PubMed:20637175, ECO:0000269|PubMed:20696890, ECO:0000269|PubMed:20699359, ECO:0000269|PubMed:21084295, ECO:0000269|PubMed:21422228, ECO:0000269|PubMed:23636092}. |
| P49662 | CASP4 | S279 | ochoa | Caspase-4 (CASP-4) (EC 3.4.22.57) (ICE and Ced-3 homolog 2) (ICH-2) (ICE(rel)-II) (Mih1) (Protease TX) [Cleaved into: Caspase-4 subunit p10; Caspase-4 subunit p20] | Inflammatory caspase that acts as the effector of the non-canonical inflammasome by mediating lipopolysaccharide (LPS)-induced pyroptosis (PubMed:25119034, PubMed:26375003, PubMed:32109412, PubMed:34671164, PubMed:37001519, PubMed:37993712, PubMed:37993714). Also indirectly activates the NLRP3 and NLRP6 inflammasomes (PubMed:23516580, PubMed:26375003, PubMed:32109412, PubMed:7797510). Acts as a thiol protease that cleaves a tetrapeptide after an Asp residue at position P1: catalyzes cleavage of CGAS, GSDMD and IL18 (PubMed:15326478, PubMed:23516580, PubMed:26375003, PubMed:28314590, PubMed:32109412, PubMed:37993712, PubMed:37993714, PubMed:7797510). Effector of the non-canonical inflammasome independently of NLRP3 inflammasome and CASP1: the non-canonical inflammasome promotes pyroptosis through GSDMD cleavage without involving secretion of cytokine IL1B (PubMed:25119034, PubMed:25121752, PubMed:26375003, PubMed:31268602, PubMed:32109412, PubMed:37993712, PubMed:37993714). In the non-canonical inflammasome, CASP4 is activated by direct binding to the lipid A moiety of LPS without the need of an upstream sensor (PubMed:25119034, PubMed:25121752, PubMed:29520027, PubMed:32510692, PubMed:32581219, PubMed:37993712). LPS-binding promotes CASP4 activation and CASP4-mediated cleavage of GSDMD and IL18, followed by IL18 secretion through the GSDMD pore, pyroptosis of infected cells and their extrusion into the gut lumen (PubMed:25119034, PubMed:25121752, PubMed:37993712, PubMed:37993714). Also indirectly promotes secretion of mature cytokines (IL1A and HMGB1) downstream of GSDMD-mediated pyroptosis via activation of the NLRP3 and NLRP6 inflammasomes (PubMed:26375003, PubMed:32109412). Involved in NLRP3-dependent CASP1 activation and IL1B secretion in response to non-canonical activators, such as UVB radiation or cholera enterotoxin (PubMed:22246630, PubMed:23516580, PubMed:24879791, PubMed:25964352, PubMed:26173988, PubMed:26174085, PubMed:26508369). Involved in NLRP6 inflammasome-dependent activation in response to lipoteichoic acid (LTA), a cell-wall component of Gram-positive bacteria, which leads to CASP1 activation and IL1B secretion (PubMed:33377178). Involved in LPS-induced IL6 secretion; this activity may not require caspase enzymatic activity (PubMed:26508369). The non-canonical inflammasome is required for innate immunity to cytosolic, but not vacuolar, bacteria (By similarity). Plays a crucial role in the restriction of S.typhimurium replication in colonic epithelial cells during infection (PubMed:25121752, PubMed:25964352). Activation of the non-canonical inflammasome in brain endothelial cells can lead to excessive pyroptosis, leading to blood-brain barrier breakdown (By similarity). Pyroptosis limits bacterial replication, while cytokine secretion promotes the recruitment and activation of immune cells and triggers mucosal inflammation (PubMed:25121752, PubMed:25964352, PubMed:26375003). May also act as an activator of adaptive immunity in dendritic cells, following activation by oxidized phospholipid 1-palmitoyl-2-arachidonoyl- sn-glycero-3-phosphorylcholine, an oxidized phospholipid (oxPAPC) (By similarity). Involved in cell death induced by endoplasmic reticulum stress and by treatment with cytotoxic APP peptides found in Alzheimer's patient brains (PubMed:15123740, PubMed:22246630, PubMed:23661706). Cleavage of GSDMD is not strictly dependent on the consensus cleavage site but depends on an exosite interface on CASP4 that recognizes and binds the Gasdermin-D, C-terminal (GSDMD-CT) part (PubMed:32109412). Catalyzes cleavage and maturation of IL18; IL18 processing also depends of the exosite interface on CASP4 (PubMed:15326478, PubMed:37993712, PubMed:37993714). In contrast, it does not directly process IL1B (PubMed:7743998, PubMed:7797510, PubMed:7797592). During non-canonical inflammasome activation, cuts CGAS and may play a role in the regulation of antiviral innate immune activation (PubMed:28314590). {ECO:0000250|UniProtKB:P70343, ECO:0000269|PubMed:15123740, ECO:0000269|PubMed:15326478, ECO:0000269|PubMed:22246630, ECO:0000269|PubMed:23516580, ECO:0000269|PubMed:23661706, ECO:0000269|PubMed:24879791, ECO:0000269|PubMed:25119034, ECO:0000269|PubMed:25121752, ECO:0000269|PubMed:25964352, ECO:0000269|PubMed:26173988, ECO:0000269|PubMed:26174085, ECO:0000269|PubMed:26375003, ECO:0000269|PubMed:26508369, ECO:0000269|PubMed:28314590, ECO:0000269|PubMed:29520027, ECO:0000269|PubMed:31268602, ECO:0000269|PubMed:32109412, ECO:0000269|PubMed:32510692, ECO:0000269|PubMed:32581219, ECO:0000269|PubMed:33377178, ECO:0000269|PubMed:34671164, ECO:0000269|PubMed:37001519, ECO:0000269|PubMed:37993714, ECO:0000269|PubMed:7743998, ECO:0000269|PubMed:7797510, ECO:0000269|PubMed:7797592}.; FUNCTION: (Microbial infection) In response to the Td92 surface protein of the periodontal pathogen T.denticola, activated by cathepsin CTSG which leads to production and secretion of IL1A and pyroptosis of gingival fibroblasts. {ECO:0000269|PubMed:29077095}. |
| P51116 | FXR2 | S566 | ochoa | RNA-binding protein FXR2 (FXR2P) (FMR1 autosomal homolog 2) | mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for adult hippocampal neurogenesis (By similarity). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (By similarity). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs: mRNAs storage into membraneless compartments regulates their translation and/or stability (By similarity). Acts as a regulator of adult hippocampal neurogenesis by regulating translation and/or stability of NOG mRNA, thereby preventing NOG protein expression in the dentate gyrus (By similarity). {ECO:0000250|UniProtKB:Q61584, ECO:0000250|UniProtKB:Q9WVR4}. |
| P51582 | P2RY4 | S333 | psp | P2Y purinoceptor 4 (P2Y4) (P2P) (Uridine nucleotide receptor) (UNR) | Receptor for UTP and UDP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. Not activated by ATP or ADP. |
| P51956 | NEK3 | S354 | ochoa | Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (HSPK 36) (Never in mitosis A-related kinase 3) (NimA-related protein kinase 3) | Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules. Regulates microtubule acetylation in neurons. Contributes to prolactin-mediated phosphorylation of PXN and VAV2. Implicated in prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells through mechanisms involving RAC1 activation and phosphorylation of PXN and VAV2. {ECO:0000269|PubMed:15618286, ECO:0000269|PubMed:17297458}. |
| P54259 | ATN1 | S42 | ochoa | Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein) | Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats. {ECO:0000250|UniProtKB:O35126, ECO:0000269|PubMed:10085113, ECO:0000269|PubMed:10973986}. |
| P78317 | RNF4 | S94 | ochoa | E3 ubiquitin-protein ligase RNF4 (EC 2.3.2.27) (RING finger protein 4) (Small nuclear ring finger protein) (Protein SNURF) | E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation (PubMed:18408734, PubMed:19307308, PubMed:35013556). Regulates the degradation of several proteins including PML and the transcriptional activator PEA3 (PubMed:18408734, PubMed:19307308, PubMed:20943951). Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation (PubMed:20212317). Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1 (PubMed:19779455, PubMed:20026589). Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation (PubMed:12885770). Catalyzes ubiquitination of sumoylated PARP1 in response to PARP1 trapping to chromatin, leading to PARP1 removal from chromatin by VCP/p97 (PubMed:35013556). {ECO:0000269|PubMed:12885770, ECO:0000269|PubMed:18408734, ECO:0000269|PubMed:19307308, ECO:0000269|PubMed:19779455, ECO:0000269|PubMed:20026589, ECO:0000269|PubMed:20212317, ECO:0000269|PubMed:20943951, ECO:0000269|PubMed:35013556}. |
| P78317 | RNF4 | S95 | ochoa | E3 ubiquitin-protein ligase RNF4 (EC 2.3.2.27) (RING finger protein 4) (Small nuclear ring finger protein) (Protein SNURF) | E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation (PubMed:18408734, PubMed:19307308, PubMed:35013556). Regulates the degradation of several proteins including PML and the transcriptional activator PEA3 (PubMed:18408734, PubMed:19307308, PubMed:20943951). Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation (PubMed:20212317). Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1 (PubMed:19779455, PubMed:20026589). Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation (PubMed:12885770). Catalyzes ubiquitination of sumoylated PARP1 in response to PARP1 trapping to chromatin, leading to PARP1 removal from chromatin by VCP/p97 (PubMed:35013556). {ECO:0000269|PubMed:12885770, ECO:0000269|PubMed:18408734, ECO:0000269|PubMed:19307308, ECO:0000269|PubMed:19779455, ECO:0000269|PubMed:20026589, ECO:0000269|PubMed:20212317, ECO:0000269|PubMed:20943951, ECO:0000269|PubMed:35013556}. |
| Q02297 | NRG1 | S443 | ochoa | Pro-neuregulin-1, membrane-bound isoform (Pro-NRG1) [Cleaved into: Neuregulin-1 (Acetylcholine receptor-inducing activity) (ARIA) (Breast cancer cell differentiation factor p45) (Glial growth factor) (Heregulin) (HRG) (Neu differentiation factor) (Sensory and motor neuron-derived factor)] | Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4 (PubMed:10867024, PubMed:7902537). Binds to ERBB3 (PubMed:20682778). Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:20682778). Ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons (By similarity). {ECO:0000250|UniProtKB:P43322, ECO:0000269|PubMed:10867024, ECO:0000269|PubMed:1348215, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:7902537}. |
| Q04637 | EIF4G1 | S1187 | ochoa|psp | Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:29987188). Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) (PubMed:29987188). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon (PubMed:29987188). Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning (PubMed:29987188). As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). {ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29987188}. |
| Q04727 | TLE4 | S300 | ochoa | Transducin-like enhancer protein 4 (Grg-4) (Groucho-related protein 4) | Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity). Involved in transcriptional repression of GNRHR and enhances MSX1-mediated transcriptional repression of CGA/alpha-GSU (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q62441}. |
| Q08378 | GOLGA3 | S1392 | ochoa | Golgin subfamily A member 3 (Golgi complex-associated protein of 170 kDa) (GCP170) (Golgin-160) | Golgi auto-antigen; probably involved in maintaining Golgi structure. |
| Q14153 | FAM53B | S178 | ochoa | Protein FAM53B (Protein simplet) | Acts as a regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) nuclear localization. {ECO:0000269|PubMed:25183871}. |
| Q15386 | UBE3C | S672 | ochoa | Ubiquitin-protein ligase E3C (EC 2.3.2.26) (HECT-type ubiquitin transferase E3C) (Homologous to E6AP carboxyl terminus homologous protein 2) (HectH2) (RTA-associated ubiquitin ligase) (RAUL) | E3 ubiquitin-protein ligase that specifically catalyzes 'Lys-29'- and 'Lys-48'-linked polyubiquitin chains (PubMed:11278995, PubMed:12692129, PubMed:16341092, PubMed:16601690, PubMed:24158444, PubMed:24811749, PubMed:25752573, PubMed:25752577, PubMed:32039437, PubMed:33637724, PubMed:34239127). Accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:32039437, PubMed:9575161). Associates with the proteasome and promotes elongation of ubiquitin chains on substrates bound to the 26S proteasome (PubMed:24158444, PubMed:28396413, PubMed:31375563). Also catalyzes 'Lys-29'- and 'Lys-48'-linked ubiquitination of 26S proteasome subunit ADRM1/RPN13 in response to proteotoxic stress, impairing the ability of the proteasome to bind and degrade ubiquitin-conjugated proteins (PubMed:24811749, PubMed:31375563). Acts as a negative regulator of autophagy by mediating 'Lys-29'- and 'Lys-48'-linked ubiquitination of PIK3C3/VPS34, promoting its degradation (PubMed:33637724). Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains; with some preference for 'Lys-48' linkages (PubMed:11278995, PubMed:16601690, PubMed:25752577). Acts as a negative regulator of type I interferon by mediating 'Lys-48'-linked ubiquitination of IRF3 and IRF7, leading to their degradation by the proteasome (PubMed:21167755). Catalyzes ubiquitination and degradation of CAND2 (PubMed:12692129). {ECO:0000269|PubMed:11278995, ECO:0000269|PubMed:12692129, ECO:0000269|PubMed:16341092, ECO:0000269|PubMed:16601690, ECO:0000269|PubMed:21167755, ECO:0000269|PubMed:24158444, ECO:0000269|PubMed:24811749, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:28396413, ECO:0000269|PubMed:31375563, ECO:0000269|PubMed:32039437, ECO:0000269|PubMed:33637724, ECO:0000269|PubMed:34239127, ECO:0000269|PubMed:9575161}. |
| Q15772 | SPEG | S2176 | ochoa | Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) | Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. |
| Q15910 | EZH2 | S375 | ochoa | Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6) | Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2 (PubMed:22323599, PubMed:30923826). Compared to EZH1-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. EZH2 can also methylate non-histone proteins such as the transcription factor GATA4 and the nuclear receptor RORA. Regulates the circadian clock via histone methylation at the promoter of the circadian genes. Essential for the CRY1/2-mediated repression of the transcriptional activation of PER1/2 by the CLOCK-BMAL1 heterodimer; involved in the di and trimethylation of 'Lys-27' of histone H3 on PER1/2 promoters which is necessary for the CRY1/2 proteins to inhibit transcription. {ECO:0000269|PubMed:14532106, ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15385962, ECO:0000269|PubMed:16179254, ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:16618801, ECO:0000269|PubMed:16717091, ECO:0000269|PubMed:16936726, ECO:0000269|PubMed:17210787, ECO:0000269|PubMed:17344414, ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:19026781, ECO:0000269|PubMed:20935635, ECO:0000269|PubMed:22323599, ECO:0000269|PubMed:23063525, ECO:0000269|PubMed:24474760, ECO:0000269|PubMed:30026490, ECO:0000269|PubMed:30923826}. |
| Q32MZ4 | LRRFIP1 | S115 | ochoa | Leucine-rich repeat flightless-interacting protein 1 (LRR FLII-interacting protein 1) (GC-binding factor 2) (TAR RNA-interacting protein) | Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:10364563, ECO:0000269|PubMed:14522076, ECO:0000269|PubMed:16199883, ECO:0000269|PubMed:19265123, ECO:0000269|PubMed:9705290}. |
| Q3MIN7 | RGL3 | S511 | ochoa | Ral guanine nucleotide dissociation stimulator-like 3 (RalGDS-like 3) | Guanine nucleotide exchange factor (GEF) for Ral-A. Potential effector of GTPase HRas and Ras-related protein M-Ras. Negatively regulates Elk-1-dependent gene induction downstream of HRas and MEKK1 (By similarity). {ECO:0000250}. |
| Q53GL0 | PLEKHO1 | S239 | ochoa | Pleckstrin homology domain-containing family O member 1 (PH domain-containing family O member 1) (C-Jun-binding protein) (JBP) (Casein kinase 2-interacting protein 1) (CK2-interacting protein 1) (CKIP-1) (Osteoclast maturation-associated gene 120 protein) | Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation. {ECO:0000269|PubMed:14729969, ECO:0000269|PubMed:15706351, ECO:0000269|PubMed:15831458, ECO:0000269|PubMed:16325375, ECO:0000269|PubMed:16987810, ECO:0000269|PubMed:17197158, ECO:0000269|PubMed:17942896}. |
| Q5M775 | SPECC1 | S37 | ochoa | Cytospin-B (Nuclear structure protein 5) (NSP5) (Sperm antigen HCMOGT-1) (Sperm antigen with calponin homology and coiled-coil domains 1) | None |
| Q5M775 | SPECC1 | S133 | ochoa | Cytospin-B (Nuclear structure protein 5) (NSP5) (Sperm antigen HCMOGT-1) (Sperm antigen with calponin homology and coiled-coil domains 1) | None |
| Q5M775 | SPECC1 | S792 | ochoa | Cytospin-B (Nuclear structure protein 5) (NSP5) (Sperm antigen HCMOGT-1) (Sperm antigen with calponin homology and coiled-coil domains 1) | None |
| Q5TCX8 | MAP3K21 | S788 | ochoa | Mitogen-activated protein kinase kinase kinase 21 (EC 2.7.11.25) (Mitogen-activated protein kinase kinase kinase MLK4) (Mixed lineage kinase 4) | Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways. {ECO:0000269|PubMed:21602844}. |
| Q5VT06 | CEP350 | S506 | ochoa | Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) | Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CPAP (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}. |
| Q5VZ89 | DENND4C | S1561 | ochoa | DENN domain-containing protein 4C | Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. {ECO:0000269|PubMed:20937701}. |
| Q68D20 | PMS2CL | S161 | ochoa | Protein PMS2CL (PMS2-C terminal-like protein) | None |
| Q6PL18 | ATAD2 | S421 | ochoa | ATPase family AAA domain-containing protein 2 (EC 3.6.1.-) (AAA nuclear coregulator cancer-associated protein) (ANCCA) | May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells. {ECO:0000269|PubMed:17998543}. |
| Q6ZNJ1 | NBEAL2 | S1830 | ochoa | Neurobeachin-like protein 2 | Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis. {ECO:0000269|PubMed:21765411, ECO:0000269|PubMed:21765412}. |
| Q702N8 | XIRP1 | S1668 | ochoa | Xin actin-binding repeat-containing protein 1 (Cardiomyopathy-associated protein 1) | Protects actin filaments from depolymerization (PubMed:15454575). Required for correct cardiac intercalated disk ultrastructure via maintenance of cell-cell adhesion stability, and as a result maintains cardiac organ morphology, conductance and heart beat rhythm (By similarity). Required for development of normal skeletal muscle morphology and muscle fiber type composition (By similarity). Plays a role in regulating muscle satellite cell activation and survival, as a result promotes muscle fiber recovery from injury and fatigue (By similarity). {ECO:0000250|UniProtKB:O70373, ECO:0000269|PubMed:15454575}. |
| Q76L83 | ASXL2 | S1153 | ochoa | Putative Polycomb group protein ASXL2 (Additional sex combs-like protein 2) | Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (PubMed:30664650, PubMed:36180891). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:30664650, PubMed:36180891). ASXL1, ASXL2 and ASXL3 function redundantly in the PR-DUB complex (By similarity) (PubMed:30664650). The ASXL proteins are essential for chromatin recruitment and transcriptional activation of associated genes (By similarity). ASXL1 and ASXL2 are important for BAP1 protein stability (PubMed:30664650). {ECO:0000250, ECO:0000250|UniProtKB:Q8BZ32, ECO:0000269|PubMed:21047783, ECO:0000269|PubMed:30664650, ECO:0000269|PubMed:36180891}. |
| Q7Z6B7 | SRGAP1 | S880 | ochoa | SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho GTPase-activating protein 13) | GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42. {ECO:0000269|PubMed:11672528}. |
| Q7Z6B7 | SRGAP1 | S940 | ochoa | SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho GTPase-activating protein 13) | GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42. {ECO:0000269|PubMed:11672528}. |
| Q7Z6Z7 | HUWE1 | S3381 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q86UT8 | CENATAC | S183 | ochoa | Centrosomal AT-AC splicing factor (Coiled-coil domain-containing protein 84) | Component of the minor spliceosome that promotes splicing of a specific, rare minor intron subtype (PubMed:34009673). Negative regulator of centrosome duplication (PubMed:31722219). Constrains centriole number by modulating the degradation of the centrosome-duplication-associated protein SASS6 in an acetylation-dependent manner. SIRT1 deacetylates CENATAC in G1 phase, allowing for SASS6 accumulation on the centrosome and subsequent procentriole assembly. The CENATAC acetylation level is restored in mitosis by NAT10, promoting SASS6 proteasome degradation by facilitating SASS6 binding to APC/C E3 ubiquitin-protein ligase complex/FZR1 (PubMed:31722219). {ECO:0000269|PubMed:31722219, ECO:0000269|PubMed:34009673}. |
| Q86VE0 | MYPOP | S177 | ochoa | Myb-related transcription factor, partner of profilin (Myb-related protein p42POP) (Partner of profilin) | Transcriptional repressor; DNA-binding protein that specifically recognizes the core sequence 5'-YAAC[GT]G-3'. Dimerization with PFN1 reduces its DNA-binding capacity (By similarity). {ECO:0000250}. |
| Q86VQ6 | TXNRD3 | S41 | ochoa | Thioredoxin reductase 3 (EC 1.8.1.9) (Thioredoxin and glutathione reductase) (Thioredoxin reductase 3 intronic transcript 1) (Thioredoxin reductase 3 neighbor gene) (Thioredoxin reductase TR2) | Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components (By similarity). {ECO:0000250|UniProtKB:Q99MD6}. |
| Q8IWX8 | CHERP | S828 | ochoa | Calcium homeostasis endoplasmic reticulum protein (ERPROT 213-21) (SR-related CTD-associated factor 6) | Involved in calcium homeostasis, growth and proliferation. {ECO:0000269|PubMed:10794731, ECO:0000269|PubMed:12656674}. |
| Q8IX01 | SUGP2 | S93 | ochoa | SURP and G-patch domain-containing protein 2 (Arginine/serine-rich-splicing factor 14) (Splicing factor, arginine/serine-rich 14) | May play a role in mRNA splicing. {ECO:0000305}. |
| Q8IXT5 | RBM12B | S107 | ochoa | RNA-binding protein 12B (RNA-binding motif protein 12B) | None |
| Q8IY92 | SLX4 | S1243 | ochoa | Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) | Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. {ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19595722, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}. |
| Q8N3R9 | PALS1 | S83 | ochoa | Protein PALS1 (MAGUK p55 subfamily member 5) (Membrane protein, palmitoylated 5) (Protein associated with Lin-7 1) | Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (PubMed:16678097, PubMed:25385611). Also involved in adherens junction biogenesis by ensuring correct localization of the exocyst complex protein EXOC4/SEC8 which allows trafficking of adherens junction structural component CDH1 to the cell surface (By similarity). Plays a role through its interaction with CDH5 in vascular lumen formation and endothelial membrane polarity (PubMed:27466317). Required during embryonic and postnatal retinal development (By similarity). Required for the maintenance of cerebellar progenitor cells in an undifferentiated proliferative state, preventing premature differentiation, and is required for cerebellar histogenesis, fissure formation, cerebellar layer organization and cortical development (By similarity). Plays a role in neuronal progenitor cell survival, potentially via promotion of mTOR signaling (By similarity). Plays a role in the radial and longitudinal extension of the myelin sheath in Schwann cells (By similarity). May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter (By similarity). Plays a role in the T-cell receptor-mediated activation of NF-kappa-B (PubMed:21479189). Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity). Required for the normal polarized localization of the vesicular marker STX4 (By similarity). Required for the correct trafficking of the myelin proteins PMP22 and MAG (By similarity). Involved in promoting phosphorylation and cytoplasmic retention of transcriptional coactivators YAP1 and WWTR1/TAZ which leads to suppression of TGFB1-dependent transcription of target genes such as CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1 and SMAD7 (By similarity). {ECO:0000250|UniProtKB:B4F7E7, ECO:0000250|UniProtKB:Q9JLB2, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:21479189, ECO:0000269|PubMed:25385611, ECO:0000269|PubMed:27466317}.; FUNCTION: (Microbial infection) Acts as an interaction partner for human coronaviruses SARS-CoV and, probably, SARS-CoV-2 envelope protein E which results in delayed formation of tight junctions and disregulation of cell polarity. {ECO:0000269|PubMed:20861307, ECO:0000303|PubMed:32891874}. |
| Q8N3Z6 | ZCCHC7 | S481 | ochoa | Zinc finger CCHC domain-containing protein 7 (TRAMP-like complex RNA-binding factor ZCCHC7) | None |
| Q8N4L1 | TMEM151A | S423 | ochoa | Transmembrane protein 151A | None |
| Q8N4S9 | MARVELD2 | S389 | ochoa | MARVEL domain-containing protein 2 (Tricellulin) | Plays a role in the formation of tricellular tight junctions and of epithelial barriers (By similarity). Required for normal hearing via its role in the separation of the endolymphatic and perilymphatic spaces of the organ of Corti in the inner ear, and for normal survival of hair cells in the organ of Corti (PubMed:17186462). {ECO:0000250|UniProtKB:Q3UZP0, ECO:0000269|PubMed:17186462}. |
| Q8N6S5 | ARL6IP6 | S29 | ochoa | ADP-ribosylation factor-like protein 6-interacting protein 6 (ARL-6-interacting protein 6) (Aip-6) (Phosphonoformate immuno-associated protein 1) | None |
| Q8N7R7 | CCNYL1 | Y120 | ochoa | Cyclin-Y-like protein 1 | Key regulator of Wnt signaling implicated in various biological processes including male fertility, embryonic neurogenesis and cortex development. Activates the cyclin-dependent kinase CDK16, and promotes sperm maturation. {ECO:0000250|UniProtKB:D3YUJ3}. |
| Q8NB78 | KDM1B | S25 | ochoa | Lysine-specific histone demethylase 2 (EC 1.14.99.66) (Flavin-containing amine oxidase domain-containing protein 1) (Lysine-specific histone demethylase 1B) | Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of GLYR1 to achieve such activity, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes (PubMed:30970244). {ECO:0000269|PubMed:23260659, ECO:0000269|PubMed:23357850, ECO:0000269|PubMed:30970244}. |
| Q8NCD3 | HJURP | S686 | ochoa | Holliday junction recognition protein (14-3-3-associated AKT substrate) (Fetal liver-expressing gene 1 protein) (Up-regulated in lung cancer 9) | Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions. {ECO:0000269|PubMed:19410544, ECO:0000269|PubMed:19410545}. |
| Q8ND76 | CCNY | Y98 | ochoa | Cyclin-Y (Cyc-Y) (Cyclin box protein 1) (Cyclin fold protein 1) (cyclin-X) | Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription. {ECO:0000269|PubMed:18060517, ECO:0000269|PubMed:19524571, ECO:0000269|PubMed:20059949, ECO:0000269|PubMed:22184064}. |
| Q8NF50 | DOCK8 | S947 | ochoa | Dedicator of cytokinesis protein 8 | Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP (PubMed:22461490, PubMed:28028151). During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC (By similarity). Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane (PubMed:28028151). Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing (PubMed:25762780). {ECO:0000250|UniProtKB:Q8C147, ECO:0000269|PubMed:22461490, ECO:0000269|PubMed:25762780, ECO:0000269|PubMed:28028151}. |
| Q8NFC6 | BOD1L1 | S2963 | ochoa | Biorientation of chromosomes in cell division protein 1-like 1 | Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}. |
| Q8NFW9 | MYRIP | S542 | ochoa | Rab effector MyRIP (Exophilin-8) (Myosin-VIIa- and Rab-interacting protein) (Synaptotagmin-like protein lacking C2 domains C) (SlaC2-c) (Slp homolog lacking C2 domains c) | Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments. Functions as a protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release (By similarity). {ECO:0000250}. |
| Q8TDW5 | SYTL5 | S319 | ochoa | Synaptotagmin-like protein 5 | May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids. |
| Q8TF17 | SH3TC2 | S29 | ochoa | SH3 domain and tetratricopeptide repeat-containing protein 2 | None |
| Q92545 | TMEM131 | S1336 | ochoa | Transmembrane protein 131 (Protein RW1) | Collagen binding transmembrane protein involved in collagen secretion by recruiting the ER-to-Golgi transport complex TRAPPIII (PubMed:32095531). May play a role in the immune response to viral infection. {ECO:0000250, ECO:0000269|PubMed:32095531}. |
| Q92545 | TMEM131 | S1515 | ochoa | Transmembrane protein 131 (Protein RW1) | Collagen binding transmembrane protein involved in collagen secretion by recruiting the ER-to-Golgi transport complex TRAPPIII (PubMed:32095531). May play a role in the immune response to viral infection. {ECO:0000250, ECO:0000269|PubMed:32095531}. |
| Q92613 | JADE3 | S571 | ochoa | Protein Jade-3 (Jade family PHD finger protein 3) (PHD finger protein 16) | Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity. {ECO:0000269|PubMed:16387653}. |
| Q92766 | RREB1 | S1174 | ochoa | Ras-responsive element-binding protein 1 (RREB-1) (Finger protein in nuclear bodies) (Raf-responsive zinc finger protein LZ321) (Zinc finger motif enhancer-binding protein 1) (Zep-1) | Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters (PubMed:10390538, PubMed:15067362, PubMed:17550981, PubMed:8816445, PubMed:9305772). Represses the angiotensinogen gene (PubMed:15067362). Negatively regulates the transcriptional activity of AR (PubMed:17550981). Potentiates the transcriptional activity of NEUROD1 (PubMed:12482979). Promotes brown adipocyte differentiation (By similarity). May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression (PubMed:8816445). {ECO:0000250|UniProtKB:Q3UH06, ECO:0000269|PubMed:10390538, ECO:0000269|PubMed:12482979, ECO:0000269|PubMed:15067362, ECO:0000269|PubMed:17550981, ECO:0000269|PubMed:8816445, ECO:0000269|PubMed:9305772}. |
| Q92785 | DPF2 | S94 | ochoa | Zinc finger protein ubi-d4 (Apoptosis response zinc finger protein) (BRG1-associated factor 45D) (BAF45D) (D4, zinc and double PHD fingers family 2) (Protein requiem) | Plays an active role in transcriptional regulation by binding modified histones H3 and H4 (PubMed:27775714, PubMed:28533407). Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells (PubMed:28533407). Might also have a role in the development and maturation of lymphoid cells (By similarity). Involved in the regulation of non-canonical NF-kappa-B pathway (PubMed:20460684). {ECO:0000250|UniProtKB:Q61103, ECO:0000269|PubMed:20460684, ECO:0000269|PubMed:27775714, ECO:0000269|PubMed:28533407}. |
| Q92870 | APBB2 | S43 | ochoa | Amyloid beta precursor protein binding family B member 2 (Amyloid-beta (A4) precursor protein-binding family B member 2) (Protein Fe65-like 1) | Plays a role in the maintenance of lens transparency, and may also play a role in muscle cell strength (By similarity). Involved in hippocampal neurite branching and neuromuscular junction formation, as a result plays a role in spatial memory functioning (By similarity). Activates transcription of APP (PubMed:14527950). {ECO:0000250|UniProtKB:Q9DBR4, ECO:0000269|PubMed:14527950}. |
| Q96GS4 | BORCS6 | S89 | ochoa | BLOC-1-related complex subunit 6 (Lysosome-dispersing protein) (Lyspersin) | As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. {ECO:0000269|PubMed:25898167}. |
| Q96HP0 | DOCK6 | S406 | ochoa | Dedicator of cytokinesis protein 6 | Acts as a guanine nucleotide exchange factor (GEF) for CDC42 and RAC1 small GTPases. Through its activation of CDC42 and RAC1, may regulate neurite outgrowth (By similarity). {ECO:0000250, ECO:0000269|PubMed:17196961}. |
| Q96RG2 | PASK | S70 | ochoa | PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (hPASK) (EC 2.7.11.1) | Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation. {ECO:0000269|PubMed:16275910, ECO:0000269|PubMed:17052199, ECO:0000269|PubMed:17595531, ECO:0000269|PubMed:20943661, ECO:0000269|PubMed:21181396, ECO:0000269|PubMed:21418524}. |
| Q9BQK8 | LPIN3 | S161 | ochoa | Phosphatidate phosphatase LPIN3 (EC 3.1.3.4) (Lipin-3) (Lipin-3-like) | Magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis therefore regulates fatty acid metabolism. {ECO:0000250|UniProtKB:Q99PI4}. |
| Q9BX63 | BRIP1 | S122 | ochoa | Fanconi anemia group J protein (EC 5.6.2.3) (BRCA1-associated C-terminal helicase 1) (BRCA1-interacting protein C-terminal helicase 1) (BRCA1-interacting protein 1) (DNA 5'-3' helicase FANCJ) | DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of chromosomal stability (PubMed:11301010, PubMed:14983014, PubMed:16116421, PubMed:16153896, PubMed:17596542, PubMed:36608669). Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination (PubMed:14983014, PubMed:16153896). Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1 (PubMed:14983014, PubMed:16153896). Involved in the repair of abasic sites at replication forks by promoting the degradation of DNA-protein cross-links: acts by catalyzing unfolding of HMCES DNA-protein cross-link via its helicase activity, exposing the underlying DNA and enabling cleavage of the DNA-protein adduct by the SPRTN metalloprotease (PubMed:16116421, PubMed:36608669). Can unwind RNA:DNA substrates (PubMed:14983014). Unwinds G-quadruplex DNA; unwinding requires a 5'-single stranded tail (PubMed:18426915, PubMed:20639400). {ECO:0000269|PubMed:11301010, ECO:0000269|PubMed:14983014, ECO:0000269|PubMed:16116421, ECO:0000269|PubMed:16153896, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639400, ECO:0000269|PubMed:36608669}. |
| Q9BXS6 | NUSAP1 | S106 | ochoa | Nucleolar and spindle-associated protein 1 (NuSAP) | Microtubule-associated protein with the capacity to bundle and stabilize microtubules (By similarity). May associate with chromosomes and promote the organization of mitotic spindle microtubules around them. {ECO:0000250, ECO:0000269|PubMed:12963707}. |
| Q9H1H9 | KIF13A | S1394 | ochoa | Kinesin-like protein KIF13A (Kinesin-like protein RBKIN) | Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR-containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abscission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis. {ECO:0000269|PubMed:19841138, ECO:0000269|PubMed:20208530}. |
| Q9H2X6 | HIPK2 | S847 | ochoa | Homeodomain-interacting protein kinase 2 (hHIPk2) (EC 2.7.11.1) | Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1, ZBTB4 and DAZAP2. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect acetylation). The phosphorylation of p53/TP53 may be mediated by a p53/TP53-HIPK2-AXIN1 complex. Involved in the response to hypoxia by acting as a transcriptional co-suppressor of HIF1A. Mediates transcriptional activation of TP73. In response to TGFB, cooperates with DAXX to activate JNK. Negative regulator through phosphorylation and subsequent proteasomal degradation of CTNNB1 and the antiapoptotic factor CTBP1. In the Wnt/beta-catenin signaling pathway acts as an intermediate kinase between MAP3K7/TAK1 and NLK to promote the proteasomal degradation of MYB. Phosphorylates CBX4 upon DNA damage and promotes its E3 SUMO-protein ligase activity. Activates CREB1 and ATF1 transcription factors by phosphorylation in response to genotoxic stress. In response to DNA damage, stabilizes PML by phosphorylation. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. Promotes angiogenesis, and is involved in erythroid differentiation, especially during fetal liver erythropoiesis. Phosphorylation of RUNX1 and EP300 stimulates EP300 transcription regulation activity. Triggers ZBTB4 protein degradation in response to DNA damage. In response to DNA damage, phosphorylates DAZAP2 which localizes DAZAP2 to the nucleus, reduces interaction of DAZAP2 with HIPK2 and prevents DAZAP2-dependent ubiquitination of HIPK2 by E3 ubiquitin-protein ligase SIAH1 and subsequent proteasomal degradation (PubMed:33591310). Modulates HMGA1 DNA-binding affinity. In response to high glucose, triggers phosphorylation-mediated subnuclear localization shifting of PDX1. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. {ECO:0000269|PubMed:11740489, ECO:0000269|PubMed:11925430, ECO:0000269|PubMed:12851404, ECO:0000269|PubMed:12874272, ECO:0000269|PubMed:14678985, ECO:0000269|PubMed:17018294, ECO:0000269|PubMed:17960875, ECO:0000269|PubMed:18695000, ECO:0000269|PubMed:18809579, ECO:0000269|PubMed:19015637, ECO:0000269|PubMed:19046997, ECO:0000269|PubMed:19448668, ECO:0000269|PubMed:20307497, ECO:0000269|PubMed:20573984, ECO:0000269|PubMed:20637728, ECO:0000269|PubMed:20980392, ECO:0000269|PubMed:21192925, ECO:0000269|PubMed:22825850, ECO:0000269|PubMed:33591310}. |
| Q9H6F5 | CCDC86 | S26 | ochoa | Coiled-coil domain-containing protein 86 (Cytokine-induced protein with coiled-coil domain) | Required for proper chromosome segregation during mitosis and error-free mitotic progression. {ECO:0000269|PubMed:36695333}. |
| Q9H7N4 | SCAF1 | S623 | ochoa | Splicing factor, arginine/serine-rich 19 (SR-related C-terminal domain-associated factor 1) (SR-related and CTD-associated factor 1) (SR-related-CTD-associated factor) (SCAF) (Serine arginine-rich pre-mRNA splicing factor SR-A1) (SR-A1) | May function in pre-mRNA splicing. {ECO:0000250}. |
| Q9H7N4 | SCAF1 | S624 | ochoa | Splicing factor, arginine/serine-rich 19 (SR-related C-terminal domain-associated factor 1) (SR-related and CTD-associated factor 1) (SR-related-CTD-associated factor) (SCAF) (Serine arginine-rich pre-mRNA splicing factor SR-A1) (SR-A1) | May function in pre-mRNA splicing. {ECO:0000250}. |
| Q9H9A7 | RMI1 | S363 | ochoa | RecQ-mediated genome instability protein 1 (BLM-associated protein of 75 kDa) (BLAP75) (FAAP75) | Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability. {ECO:0000269|PubMed:15775963, ECO:0000269|PubMed:16537486, ECO:0000269|PubMed:16595695}. |
| Q9H9J4 | USP42 | S431 | ochoa | Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.4.19.12) (Deubiquitinating enzyme 42) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) | Deubiquitinating enzyme which may play an important role during spermatogenesis. {ECO:0000250}. |
| Q9H9J4 | USP42 | S1007 | ochoa | Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.4.19.12) (Deubiquitinating enzyme 42) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) | Deubiquitinating enzyme which may play an important role during spermatogenesis. {ECO:0000250}. |
| Q9HC52 | CBX8 | S190 | ochoa | Chromobox protein homolog 8 (Polycomb 3 homolog) (Pc3) (hPc3) (Rectachrome 1) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269|PubMed:21282530}. |
| Q9HCG8 | CWC22 | T101 | ochoa | Pre-mRNA-splicing factor CWC22 homolog (Nucampholin homolog) (fSAPb) | Required for pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:12226669, PubMed:22961380, PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Promotes exon-junction complex (EJC) assembly (PubMed:22959432, PubMed:22961380). Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay. {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12226669, ECO:0000269|PubMed:22959432, ECO:0000269|PubMed:22961380, ECO:0000269|PubMed:23236153, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000305|PubMed:33509932}. |
| Q9HCK8 | CHD8 | S2414 | ochoa | Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.-) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1) | ATP-dependent chromatin-remodeling factor, it slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. Regulates alternative splicing of a core group of genes involved in neuronal differentiation, cell cycle and DNA repair. Enables H3K36me3-coupled transcription elongation and co-transcriptional RNA processing likely via interaction with HNRNPL. {ECO:0000255|HAMAP-Rule:MF_03071, ECO:0000269|PubMed:17938208, ECO:0000269|PubMed:18378692, ECO:0000269|PubMed:28533432, ECO:0000269|PubMed:36537238}. |
| Q9NRA8 | EIF4ENIF1 | S680 | ochoa | Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) | EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}. |
| Q9NYP9 | MIS18A | S28 | ochoa | Protein Mis18-alpha (FAPP1-associated protein 1) | Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038}. |
| Q9NZM1 | MYOF | S1036 | ochoa | Myoferlin (Fer-1-like protein 3) | Calcium/phospholipid-binding protein that plays a role in the plasmalemma repair mechanism of endothelial cells that permits rapid resealing of membranes disrupted by mechanical stress. Involved in endocytic recycling. Implicated in VEGF signal transduction by regulating the levels of the receptor KDR (By similarity). {ECO:0000250}. |
| Q9NZM3 | ITSN2 | S1118 | ochoa | Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein) | Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:23999003}. |
| Q9P241 | ATP10D | S520 | ochoa | Phospholipid-transporting ATPase VD (EC 7.6.2.1) (ATPase class V type 10D) (P4-ATPase flippase complex alpha subunit ATP10D) | Catalytic component of a P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of glucosylceramide (GlcCer) from the outer to the inner leaflet of the plasma membrane. {ECO:0000269|PubMed:30530492}. |
| Q9P2G1 | ANKIB1 | S938 | ochoa | Ankyrin repeat and IBR domain-containing protein 1 (EC 2.3.2.31) | Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates. {ECO:0000250}. |
| Q9UH99 | SUN2 | S20 | ochoa | SUN domain-containing protein 2 (Protein unc-84 homolog B) (Rab5-interacting protein) (Rab5IP) (Sad1/unc-84 protein-like 2) | As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Required for nuclear migration in retinal photoreceptor progenitors implicating association with cytoplasmic dynein-dynactin and kinesin motor complexes, and probably B-type lamins; SUN1 and SUN2 seem to act redundantly. The SUN1/2:KASH5 LINC complex couples telomeres to microtubules during meiosis; SUN1 and SUN2 seem to act at least partial redundantly. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5. {ECO:0000250|UniProtKB:Q8BJS4, ECO:0000269|PubMed:18396275, ECO:0000305}. |
| Q9UH99 | SUN2 | S62 | ochoa | SUN domain-containing protein 2 (Protein unc-84 homolog B) (Rab5-interacting protein) (Rab5IP) (Sad1/unc-84 protein-like 2) | As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Required for nuclear migration in retinal photoreceptor progenitors implicating association with cytoplasmic dynein-dynactin and kinesin motor complexes, and probably B-type lamins; SUN1 and SUN2 seem to act redundantly. The SUN1/2:KASH5 LINC complex couples telomeres to microtubules during meiosis; SUN1 and SUN2 seem to act at least partial redundantly. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5. {ECO:0000250|UniProtKB:Q8BJS4, ECO:0000269|PubMed:18396275, ECO:0000305}. |
| Q9UPN4 | CEP131 | S498 | ochoa | Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) (Pre-acrosome localization protein 1) | Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Also acts as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). Essential for maintaining proper centriolar satellite integrity (PubMed:30804208). {ECO:0000250|UniProtKB:Q62036, ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:22797915, ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:24185901, ECO:0000269|PubMed:24550735, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:30804208}. |
| Q9UQ35 | SRRM2 | S149 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | Y2693 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y2H5 | PLEKHA6 | S313 | ochoa | Pleckstrin homology domain-containing family A member 6 (PH domain-containing family A member 6) (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3) | None |
| Q9Y383 | LUC7L2 | S353 | ochoa | Putative RNA-binding protein Luc7-like 2 | May bind to RNA via its Arg/Ser-rich domain. |
| Q9Y4G8 | RAPGEF2 | S584 | ochoa | Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1) | Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Also acts as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP (PubMed:23800469, PubMed:10801446) or not (PubMed:10548487, PubMed:10608844, PubMed:11359771). Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Also provides inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions. {ECO:0000269|PubMed:10548487, ECO:0000269|PubMed:10608844, ECO:0000269|PubMed:10608883, ECO:0000269|PubMed:10801446, ECO:0000269|PubMed:10934204, ECO:0000269|PubMed:11359771, ECO:0000269|PubMed:12391161, ECO:0000269|PubMed:16272156, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:23800469}. |
| P78417 | GSTO1 | S23 | Sugiyama | Glutathione S-transferase omega-1 (GSTO-1) (EC 2.5.1.18) (Glutathione S-transferase omega 1-1) (GSTO 1-1) (Glutathione-dependent dehydroascorbate reductase) (EC 1.8.5.1) (Monomethylarsonic acid reductase) (MMA(V) reductase) (EC 1.20.4.2) (S-(Phenacyl)glutathione reductase) (SPG-R) | Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Also has glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid. {ECO:0000269|PubMed:10783391, ECO:0000269|PubMed:11511179, ECO:0000269|PubMed:17226937, ECO:0000269|PubMed:18028863, ECO:0000269|PubMed:21106529}. |
| P61254 | RPL26 | S31 | Sugiyama | Large ribosomal subunit protein uL24 (60S ribosomal protein L26) | Component of the large ribosomal subunit (PubMed:23636399, PubMed:26100019, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:26100019, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:26100019}. |
| Q9UNX3 | RPL26L1 | S31 | Sugiyama | Ribosomal protein uL24-like (60S ribosomal protein L26-like 1) (Large ribosomal subunit protein uL24-like 1) | None |
| P54278 | PMS2 | S547 | Sugiyama | Mismatch repair endonuclease PMS2 (EC 3.1.-.-) (DNA mismatch repair protein PMS2) (PMS1 protein homolog 2) | Component of the post-replicative DNA mismatch repair system (MMR) (PubMed:30653781, PubMed:35189042). Heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Possesses an ATPase activity, but in the absence of gross structural changes, ATP hydrolysis may not be necessary for proficient mismatch repair (PubMed:35189042). {ECO:0000269|PubMed:16873062, ECO:0000269|PubMed:18206974, ECO:0000269|PubMed:23709753, ECO:0000269|PubMed:30653781, ECO:0000269|PubMed:35189042}. |
| Q9BZI1 | IRX2 | S325 | SIGNOR | Iroquois-class homeodomain protein IRX-2 (Homeodomain protein IRXA2) (Iroquois homeobox protein 2) | None |
| Q96HP0 | DOCK6 | S190 | Sugiyama | Dedicator of cytokinesis protein 6 | Acts as a guanine nucleotide exchange factor (GEF) for CDC42 and RAC1 small GTPases. Through its activation of CDC42 and RAC1, may regulate neurite outgrowth (By similarity). {ECO:0000250, ECO:0000269|PubMed:17196961}. |
| Q9UM73 | ALK | S1448 | Sugiyama | ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246) | Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system (PubMed:11121404, PubMed:11387242, PubMed:16317043, PubMed:17274988, PubMed:30061385, PubMed:34646012, PubMed:34819673). Also acts as a key thinness protein involved in the resistance to weight gain: in hypothalamic neurons, controls energy expenditure acting as a negative regulator of white adipose tissue lipolysis and sympathetic tone to fine-tune energy homeostasis (By similarity). Following activation by ALKAL2 ligand at the cell surface, transduces an extracellular signal into an intracellular response (PubMed:30061385, PubMed:33411331, PubMed:34646012, PubMed:34819673). In contrast, ALKAL1 is not a potent physiological ligand for ALK (PubMed:34646012). Ligand-binding to the extracellular domain induces tyrosine kinase activation, leading to activation of the mitogen-activated protein kinase (MAPK) pathway (PubMed:34819673). Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif (PubMed:15226403, PubMed:16878150). Induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1 (PubMed:15226403, PubMed:16878150). ALK activation may also be regulated by pleiotrophin (PTN) and midkine (MDK) (PubMed:11278720, PubMed:11809760, PubMed:12107166, PubMed:12122009). PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation (PubMed:11278720, PubMed:11809760, PubMed:12107166). MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction (PubMed:12122009). Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase (PubMed:15226403, PubMed:16878150). Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK (PubMed:15226403, PubMed:16878150). {ECO:0000250|UniProtKB:P97793, ECO:0000269|PubMed:11121404, ECO:0000269|PubMed:11278720, ECO:0000269|PubMed:11387242, ECO:0000269|PubMed:11809760, ECO:0000269|PubMed:12107166, ECO:0000269|PubMed:12122009, ECO:0000269|PubMed:15226403, ECO:0000269|PubMed:16317043, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:17274988, ECO:0000269|PubMed:30061385, ECO:0000269|PubMed:33411331, ECO:0000269|PubMed:34646012, ECO:0000269|PubMed:34819673}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-383280 | Nuclear Receptor transcription pathway | 1.253673e-07 | 6.902 |
| R-HSA-5545483 | Defective Mismatch Repair Associated With MLH1 | 1.635596e-04 | 3.786 |
| R-HSA-5632987 | Defective Mismatch Repair Associated With PMS2 | 1.635596e-04 | 3.786 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 5.594400e-04 | 3.252 |
| R-HSA-5423599 | Diseases of Mismatch Repair (MMR) | 1.004047e-03 | 2.998 |
| R-HSA-1306955 | GRB7 events in ERBB2 signaling | 1.437208e-03 | 2.842 |
| R-HSA-9675135 | Diseases of DNA repair | 1.613135e-03 | 2.792 |
| R-HSA-9700649 | Drug resistance of ALK mutants | 9.087474e-03 | 2.042 |
| R-HSA-9717264 | ASP-3026-resistant ALK mutants | 9.087474e-03 | 2.042 |
| R-HSA-9717326 | crizotinib-resistant ALK mutants | 9.087474e-03 | 2.042 |
| R-HSA-9717329 | lorlatinib-resistant ALK mutants | 9.087474e-03 | 2.042 |
| R-HSA-9717319 | brigatinib-resistant ALK mutants | 9.087474e-03 | 2.042 |
| R-HSA-9717316 | alectinib-resistant ALK mutants | 9.087474e-03 | 2.042 |
| R-HSA-9717301 | NVP-TAE684-resistant ALK mutants | 9.087474e-03 | 2.042 |
| R-HSA-9717323 | ceritinib-resistant ALK mutants | 9.087474e-03 | 2.042 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 9.629196e-03 | 2.016 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 3.617567e-03 | 2.442 |
| R-HSA-72172 | mRNA Splicing | 4.740868e-03 | 2.324 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 6.470532e-03 | 2.189 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 6.092384e-03 | 2.215 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 5.684161e-03 | 2.245 |
| R-HSA-201556 | Signaling by ALK | 8.906675e-03 | 2.050 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 9.987440e-03 | 2.001 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 9.629196e-03 | 2.016 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 8.301933e-03 | 2.081 |
| R-HSA-5620971 | Pyroptosis | 3.892729e-03 | 2.410 |
| R-HSA-9830369 | Kidney development | 5.183730e-03 | 2.285 |
| R-HSA-8939211 | ESR-mediated signaling | 9.705624e-03 | 2.013 |
| R-HSA-9686114 | Non-canonical inflammasome activation | 1.204326e-02 | 1.919 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 1.204326e-02 | 1.919 |
| R-HSA-417957 | P2Y receptors | 1.204326e-02 | 1.919 |
| R-HSA-74160 | Gene expression (Transcription) | 1.299974e-02 | 1.886 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 1.333932e-02 | 1.875 |
| R-HSA-9948011 | CASP5 inflammasome assembly | 1.809292e-02 | 1.742 |
| R-HSA-9692912 | SARS-CoV-1 targets PDZ proteins in cell-cell junction | 1.809292e-02 | 1.742 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 2.066398e-02 | 1.685 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 2.229001e-02 | 1.652 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.229001e-02 | 1.652 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.229001e-02 | 1.652 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 2.229001e-02 | 1.652 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 1.756973e-02 | 1.755 |
| R-HSA-5358508 | Mismatch Repair | 1.909019e-02 | 1.719 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 1.756973e-02 | 1.755 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 1.756973e-02 | 1.755 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 1.610369e-02 | 1.793 |
| R-HSA-418038 | Nucleotide-like (purinergic) receptors | 1.909019e-02 | 1.719 |
| R-HSA-9831926 | Nephron development | 1.909019e-02 | 1.719 |
| R-HSA-73857 | RNA Polymerase II Transcription | 2.266177e-02 | 1.645 |
| R-HSA-212436 | Generic Transcription Pathway | 1.615097e-02 | 1.792 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 2.488594e-02 | 1.604 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 2.488594e-02 | 1.604 |
| R-HSA-8953854 | Metabolism of RNA | 2.537430e-02 | 1.596 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 2.491279e-02 | 1.604 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 2.499493e-02 | 1.602 |
| R-HSA-429947 | Deadenylation of mRNA | 3.116698e-02 | 1.506 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 3.308459e-02 | 1.480 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 3.193819e-02 | 1.496 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 3.200542e-02 | 1.495 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 3.200542e-02 | 1.495 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 2.902901e-02 | 1.537 |
| R-HSA-5693538 | Homology Directed Repair | 3.355843e-02 | 1.474 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 3.116698e-02 | 1.506 |
| R-HSA-166208 | mTORC1-mediated signalling | 2.747095e-02 | 1.561 |
| R-HSA-9830674 | Formation of the ureteric bud | 2.929544e-02 | 1.533 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 2.780932e-02 | 1.556 |
| R-HSA-8848021 | Signaling by PTK6 | 2.780932e-02 | 1.556 |
| R-HSA-5218859 | Regulated Necrosis | 3.301782e-02 | 1.481 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 3.500835e-02 | 1.456 |
| R-HSA-844615 | The AIM2 inflammasome | 3.586068e-02 | 1.445 |
| R-HSA-162582 | Signal Transduction | 3.743711e-02 | 1.427 |
| R-HSA-9960519 | CASP4-mediated substrate cleavage | 4.462444e-02 | 1.350 |
| R-HSA-9960525 | CASP5-mediated substrate cleavage | 4.462444e-02 | 1.350 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 4.119631e-02 | 1.385 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 4.332983e-02 | 1.363 |
| R-HSA-844623 | The IPAF inflammasome | 4.462444e-02 | 1.350 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 4.119631e-02 | 1.385 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 4.332983e-02 | 1.363 |
| R-HSA-5689603 | UCH proteinases | 4.232946e-02 | 1.373 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 4.332983e-02 | 1.363 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 4.110052e-02 | 1.386 |
| R-HSA-9851151 | MDK and PTN in ALK signaling | 5.330907e-02 | 1.273 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 4.996917e-02 | 1.301 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 4.996917e-02 | 1.301 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 5.458553e-02 | 1.263 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 4.874773e-02 | 1.312 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 5.330907e-02 | 1.273 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 5.458553e-02 | 1.263 |
| R-HSA-9706374 | FLT3 signaling through SRC family kinases | 5.330907e-02 | 1.273 |
| R-HSA-376176 | Signaling by ROBO receptors | 5.381398e-02 | 1.269 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 5.458553e-02 | 1.263 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 5.694818e-02 | 1.245 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 5.703948e-02 | 1.244 |
| R-HSA-73894 | DNA Repair | 6.064229e-02 | 1.217 |
| R-HSA-74713 | IRS activation | 6.191529e-02 | 1.208 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 7.044381e-02 | 1.152 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 6.595362e-02 | 1.181 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 6.191529e-02 | 1.208 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 7.063633e-02 | 1.151 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 6.424394e-02 | 1.192 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 6.177820e-02 | 1.209 |
| R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 7.044381e-02 | 1.152 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 6.506510e-02 | 1.187 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 7.078925e-02 | 1.150 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 7.250762e-02 | 1.140 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 7.044381e-02 | 1.152 |
| R-HSA-1640170 | Cell Cycle | 7.116621e-02 | 1.148 |
| R-HSA-165159 | MTOR signalling | 7.704824e-02 | 1.113 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 6.995418e-02 | 1.155 |
| R-HSA-9732724 | IFNG signaling activates MAPKs | 8.727048e-02 | 1.059 |
| R-HSA-112412 | SOS-mediated signalling | 8.727048e-02 | 1.059 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 8.727048e-02 | 1.059 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 9.557001e-02 | 1.020 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 9.557001e-02 | 1.020 |
| R-HSA-9700645 | ALK mutants bind TKIs | 1.037946e-01 | 0.984 |
| R-HSA-9948001 | CASP4 inflammasome assembly | 1.119449e-01 | 0.951 |
| R-HSA-1250342 | PI3K events in ERBB4 signaling | 1.280253e-01 | 0.893 |
| R-HSA-1250347 | SHC1 events in ERBB4 signaling | 1.745516e-01 | 0.758 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 2.041907e-01 | 0.690 |
| R-HSA-774815 | Nucleosome assembly | 8.508390e-02 | 1.070 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 8.508390e-02 | 1.070 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 2.257241e-01 | 0.646 |
| R-HSA-72649 | Translation initiation complex formation | 1.105617e-01 | 0.956 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 1.164686e-01 | 0.934 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 1.377290e-01 | 0.861 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 1.377290e-01 | 0.861 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 2.803586e-01 | 0.552 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 1.470858e-01 | 0.832 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 2.869130e-01 | 0.542 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 2.869130e-01 | 0.542 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 2.998442e-01 | 0.523 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 2.998442e-01 | 0.523 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 3.062223e-01 | 0.514 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 1.693864e-01 | 0.771 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 1.054081e-01 | 0.977 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 1.054081e-01 | 0.977 |
| R-HSA-380287 | Centrosome maturation | 1.758608e-01 | 0.755 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 2.220839e-01 | 0.653 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 2.321305e-01 | 0.634 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 2.489335e-01 | 0.604 |
| R-HSA-192823 | Viral mRNA Translation | 2.792525e-01 | 0.554 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 2.960745e-01 | 0.529 |
| R-HSA-68962 | Activation of the pre-replicative complex | 2.803586e-01 | 0.552 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 2.287780e-01 | 0.641 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 1.224538e-01 | 0.912 |
| R-HSA-448706 | Interleukin-1 processing | 1.037946e-01 | 0.984 |
| R-HSA-198203 | PI3K/AKT activation | 1.119449e-01 | 0.951 |
| R-HSA-156902 | Peptide chain elongation | 2.220839e-01 | 0.653 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 1.359567e-01 | 0.867 |
| R-HSA-9956593 | Microbial factors inhibit CASP4 activity | 1.438164e-01 | 0.842 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 1.745516e-01 | 0.758 |
| R-HSA-4641265 | Repression of WNT target genes | 1.359567e-01 | 0.867 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 2.523000e-01 | 0.598 |
| R-HSA-8849473 | PTK6 Expression | 8.727048e-02 | 1.059 |
| R-HSA-5673000 | RAF activation | 3.125426e-01 | 0.505 |
| R-HSA-141333 | Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB | 1.280253e-01 | 0.893 |
| R-HSA-72764 | Eukaryotic Translation Termination | 2.523000e-01 | 0.598 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 2.186114e-01 | 0.660 |
| R-HSA-2424491 | DAP12 signaling | 2.803586e-01 | 0.552 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 2.737445e-01 | 0.563 |
| R-HSA-1227986 | Signaling by ERBB2 | 1.285127e-01 | 0.891 |
| R-HSA-176974 | Unwinding of DNA | 1.037946e-01 | 0.984 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 1.037946e-01 | 0.984 |
| R-HSA-9762292 | Regulation of CDH11 function | 1.119449e-01 | 0.951 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 1.745516e-01 | 0.758 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 1.895057e-01 | 0.722 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 3.062223e-01 | 0.514 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 2.523000e-01 | 0.598 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 2.388446e-01 | 0.622 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 2.979645e-01 | 0.526 |
| R-HSA-74749 | Signal attenuation | 1.119449e-01 | 0.951 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 1.895057e-01 | 0.722 |
| R-HSA-912631 | Regulation of signaling by CBL | 1.968815e-01 | 0.706 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 3.062223e-01 | 0.514 |
| R-HSA-9603381 | Activated NTRK3 signals through PI3K | 8.727048e-02 | 1.059 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 1.516051e-01 | 0.819 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 1.593235e-01 | 0.798 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 1.254743e-01 | 0.901 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 3.062223e-01 | 0.514 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 1.194517e-01 | 0.923 |
| R-HSA-140179 | Amine Oxidase reactions | 1.968815e-01 | 0.706 |
| R-HSA-2564830 | Cytosolic iron-sulfur cluster assembly | 1.895057e-01 | 0.722 |
| R-HSA-420029 | Tight junction interactions | 2.466787e-01 | 0.608 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 2.054281e-01 | 0.687 |
| R-HSA-9700206 | Signaling by ALK in cancer | 9.616708e-02 | 1.017 |
| R-HSA-9711097 | Cellular response to starvation | 2.177991e-01 | 0.662 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 2.803586e-01 | 0.552 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 2.859861e-01 | 0.544 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 2.859861e-01 | 0.544 |
| R-HSA-9842663 | Signaling by LTK | 1.359567e-01 | 0.867 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 2.466787e-01 | 0.608 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 2.466787e-01 | 0.608 |
| R-HSA-180746 | Nuclear import of Rev protein | 3.125426e-01 | 0.505 |
| R-HSA-2408557 | Selenocysteine synthesis | 2.725150e-01 | 0.565 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 2.107099e-01 | 0.676 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 2.490433e-01 | 0.604 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 2.397572e-01 | 0.620 |
| R-HSA-428540 | Activation of RAC1 | 1.280253e-01 | 0.893 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 2.826199e-01 | 0.549 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 2.998442e-01 | 0.523 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 9.616708e-02 | 1.017 |
| R-HSA-1236394 | Signaling by ERBB4 | 1.726185e-01 | 0.763 |
| R-HSA-9768777 | Regulation of NPAS4 gene transcription | 1.037946e-01 | 0.984 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 1.037946e-01 | 0.984 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 2.998442e-01 | 0.523 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 8.508390e-02 | 1.070 |
| R-HSA-9008059 | Interleukin-37 signaling | 2.803586e-01 | 0.552 |
| R-HSA-5683057 | MAPK family signaling cascades | 1.208858e-01 | 0.918 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 3.062223e-01 | 0.514 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 1.820626e-01 | 0.740 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 2.998442e-01 | 0.523 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 2.737445e-01 | 0.563 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 8.554601e-02 | 1.068 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 1.309547e-01 | 0.883 |
| R-HSA-5578768 | Physiological factors | 1.516051e-01 | 0.819 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 2.196307e-01 | 0.658 |
| R-HSA-69275 | G2/M Transition | 2.883356e-01 | 0.540 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 2.932884e-01 | 0.533 |
| R-HSA-392517 | Rap1 signalling | 1.968815e-01 | 0.706 |
| R-HSA-9620244 | Long-term potentiation | 2.466787e-01 | 0.608 |
| R-HSA-75109 | Triglyceride biosynthesis | 2.603346e-01 | 0.584 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 1.309547e-01 | 0.883 |
| R-HSA-69190 | DNA strand elongation | 2.934080e-01 | 0.533 |
| R-HSA-9930044 | Nuclear RNA decay | 2.998442e-01 | 0.523 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 2.932884e-01 | 0.533 |
| R-HSA-1500620 | Meiosis | 2.087487e-01 | 0.680 |
| R-HSA-69481 | G2/M Checkpoints | 1.413119e-01 | 0.850 |
| R-HSA-168255 | Influenza Infection | 2.710613e-01 | 0.567 |
| R-HSA-3214842 | HDMs demethylate histones | 2.466787e-01 | 0.608 |
| R-HSA-936837 | Ion transport by P-type ATPases | 1.408330e-01 | 0.851 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 1.516051e-01 | 0.819 |
| R-HSA-196836 | Vitamin C (ascorbate) metabolism | 2.114338e-01 | 0.675 |
| R-HSA-1483213 | Synthesis of PE | 2.603346e-01 | 0.584 |
| R-HSA-622312 | Inflammasomes | 2.670700e-01 | 0.573 |
| R-HSA-2586552 | Signaling by Leptin | 1.119449e-01 | 0.951 |
| R-HSA-9020558 | Interleukin-2 signaling | 1.200216e-01 | 0.921 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 2.186114e-01 | 0.660 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 1.476550e-01 | 0.831 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 2.036742e-01 | 0.691 |
| R-HSA-4839726 | Chromatin organization | 2.320015e-01 | 0.635 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 1.408330e-01 | 0.851 |
| R-HSA-354192 | Integrin signaling | 2.998442e-01 | 0.523 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 1.726185e-01 | 0.763 |
| R-HSA-5688426 | Deubiquitination | 1.084837e-01 | 0.965 |
| R-HSA-2559583 | Cellular Senescence | 2.735223e-01 | 0.563 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 2.998442e-01 | 0.523 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 8.237765e-02 | 1.084 |
| R-HSA-983712 | Ion channel transport | 2.957672e-01 | 0.529 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 1.669721e-01 | 0.777 |
| R-HSA-264876 | Insulin processing | 2.603346e-01 | 0.584 |
| R-HSA-844456 | The NLRP3 inflammasome | 1.968815e-01 | 0.706 |
| R-HSA-6807070 | PTEN Regulation | 1.716632e-01 | 0.765 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 1.208825e-01 | 0.918 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 2.927136e-01 | 0.534 |
| R-HSA-1266695 | Interleukin-7 signaling | 2.466787e-01 | 0.608 |
| R-HSA-982772 | Growth hormone receptor signaling | 2.327725e-01 | 0.633 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 1.153417e-01 | 0.938 |
| R-HSA-5633007 | Regulation of TP53 Activity | 2.225530e-01 | 0.653 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 2.998442e-01 | 0.523 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 2.083585e-01 | 0.681 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 1.439521e-01 | 0.842 |
| R-HSA-9020591 | Interleukin-12 signaling | 1.791129e-01 | 0.747 |
| R-HSA-447115 | Interleukin-12 family signaling | 2.187430e-01 | 0.660 |
| R-HSA-9609690 | HCMV Early Events | 3.131505e-01 | 0.504 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 3.188057e-01 | 0.496 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 3.188057e-01 | 0.496 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 3.250121e-01 | 0.488 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 3.250121e-01 | 0.488 |
| R-HSA-114604 | GPVI-mediated activation cascade | 3.250121e-01 | 0.488 |
| R-HSA-74158 | RNA Polymerase III Transcription | 3.250121e-01 | 0.488 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 3.250121e-01 | 0.488 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 3.311624e-01 | 0.480 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 3.311624e-01 | 0.480 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 3.372571e-01 | 0.472 |
| R-HSA-5357801 | Programmed Cell Death | 3.380256e-01 | 0.471 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 3.432965e-01 | 0.464 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 3.432965e-01 | 0.464 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 3.432965e-01 | 0.464 |
| R-HSA-68875 | Mitotic Prophase | 3.460941e-01 | 0.461 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 3.492813e-01 | 0.457 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 3.492813e-01 | 0.457 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 3.492813e-01 | 0.457 |
| R-HSA-451927 | Interleukin-2 family signaling | 3.492813e-01 | 0.457 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 3.492813e-01 | 0.457 |
| R-HSA-73886 | Chromosome Maintenance | 3.493931e-01 | 0.457 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 3.552119e-01 | 0.450 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 3.552119e-01 | 0.450 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 3.552119e-01 | 0.450 |
| R-HSA-9607240 | FLT3 Signaling | 3.552119e-01 | 0.450 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 3.610889e-01 | 0.442 |
| R-HSA-5674135 | MAP2K and MAPK activation | 3.610889e-01 | 0.442 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 3.610889e-01 | 0.442 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 3.610889e-01 | 0.442 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 3.610889e-01 | 0.442 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 3.669126e-01 | 0.435 |
| R-HSA-9710421 | Defective pyroptosis | 3.726836e-01 | 0.429 |
| R-HSA-449147 | Signaling by Interleukins | 3.768198e-01 | 0.424 |
| R-HSA-2172127 | DAP12 interactions | 3.784023e-01 | 0.422 |
| R-HSA-156581 | Methylation | 3.784023e-01 | 0.422 |
| R-HSA-5683826 | Surfactant metabolism | 3.784023e-01 | 0.422 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 3.824339e-01 | 0.417 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 3.840693e-01 | 0.416 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 3.840693e-01 | 0.416 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 3.840693e-01 | 0.416 |
| R-HSA-1474165 | Reproduction | 3.852828e-01 | 0.414 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 3.896850e-01 | 0.409 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 3.896850e-01 | 0.409 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 3.896850e-01 | 0.409 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 3.896850e-01 | 0.409 |
| R-HSA-6802949 | Signaling by RAS mutants | 3.896850e-01 | 0.409 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 3.896850e-01 | 0.409 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 3.896850e-01 | 0.409 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 3.896850e-01 | 0.409 |
| R-HSA-72766 | Translation | 3.925267e-01 | 0.406 |
| R-HSA-1483191 | Synthesis of PC | 3.952498e-01 | 0.403 |
| R-HSA-72312 | rRNA processing | 4.047039e-01 | 0.393 |
| R-HSA-9766229 | Degradation of CDH1 | 4.062286e-01 | 0.391 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 4.062286e-01 | 0.391 |
| R-HSA-3247509 | Chromatin modifying enzymes | 4.095813e-01 | 0.388 |
| R-HSA-109704 | PI3K Cascade | 4.116436e-01 | 0.385 |
| R-HSA-9948299 | Ribosome-associated quality control | 4.140080e-01 | 0.383 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 4.163854e-01 | 0.381 |
| R-HSA-9864848 | Complex IV assembly | 4.170095e-01 | 0.380 |
| R-HSA-912446 | Meiotic recombination | 4.170095e-01 | 0.380 |
| R-HSA-68949 | Orc1 removal from chromatin | 4.223268e-01 | 0.374 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 4.223268e-01 | 0.374 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 4.223268e-01 | 0.374 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 4.275959e-01 | 0.369 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 4.275959e-01 | 0.369 |
| R-HSA-1221632 | Meiotic synapsis | 4.275959e-01 | 0.369 |
| R-HSA-193648 | NRAGE signals death through JNK | 4.431186e-01 | 0.353 |
| R-HSA-69278 | Cell Cycle, Mitotic | 4.478423e-01 | 0.349 |
| R-HSA-9609646 | HCMV Infection | 4.481290e-01 | 0.349 |
| R-HSA-9764561 | Regulation of CDH1 Function | 4.481994e-01 | 0.349 |
| R-HSA-112399 | IRS-mediated signalling | 4.481994e-01 | 0.349 |
| R-HSA-5621480 | Dectin-2 family | 4.481994e-01 | 0.349 |
| R-HSA-421270 | Cell-cell junction organization | 4.505068e-01 | 0.346 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 4.532341e-01 | 0.344 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 4.532341e-01 | 0.344 |
| R-HSA-9679191 | Potential therapeutics for SARS | 4.542913e-01 | 0.343 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 4.542913e-01 | 0.343 |
| R-HSA-194441 | Metabolism of non-coding RNA | 4.582232e-01 | 0.339 |
| R-HSA-191859 | snRNP Assembly | 4.582232e-01 | 0.339 |
| R-HSA-8979227 | Triglyceride metabolism | 4.582232e-01 | 0.339 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 4.631670e-01 | 0.334 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 4.631670e-01 | 0.334 |
| R-HSA-156590 | Glutathione conjugation | 4.631670e-01 | 0.334 |
| R-HSA-69620 | Cell Cycle Checkpoints | 4.670339e-01 | 0.331 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 4.680661e-01 | 0.330 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 4.680661e-01 | 0.330 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 4.680661e-01 | 0.330 |
| R-HSA-6784531 | tRNA processing in the nucleus | 4.729207e-01 | 0.325 |
| R-HSA-9707616 | Heme signaling | 4.729207e-01 | 0.325 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 4.729207e-01 | 0.325 |
| R-HSA-9610379 | HCMV Late Events | 4.753257e-01 | 0.323 |
| R-HSA-2262752 | Cellular responses to stress | 4.782828e-01 | 0.320 |
| R-HSA-74751 | Insulin receptor signalling cascade | 4.824984e-01 | 0.317 |
| R-HSA-2428924 | IGF1R signaling cascade | 4.824984e-01 | 0.317 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 4.872222e-01 | 0.312 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 4.872222e-01 | 0.312 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 4.919032e-01 | 0.308 |
| R-HSA-2408522 | Selenoamino acid metabolism | 4.958672e-01 | 0.305 |
| R-HSA-8953897 | Cellular responses to stimuli | 4.999752e-01 | 0.301 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 5.011382e-01 | 0.300 |
| R-HSA-68886 | M Phase | 5.032327e-01 | 0.298 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 5.051698e-01 | 0.297 |
| R-HSA-913531 | Interferon Signaling | 5.051698e-01 | 0.297 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 5.102065e-01 | 0.292 |
| R-HSA-204005 | COPII-mediated vesicle transport | 5.102065e-01 | 0.292 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 5.102065e-01 | 0.292 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 5.102065e-01 | 0.292 |
| R-HSA-446728 | Cell junction organization | 5.129901e-01 | 0.290 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 5.146790e-01 | 0.288 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 5.187144e-01 | 0.285 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 5.191110e-01 | 0.285 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 5.191110e-01 | 0.285 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 5.222601e-01 | 0.282 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 5.235028e-01 | 0.281 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 5.235028e-01 | 0.281 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 5.235028e-01 | 0.281 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 5.243188e-01 | 0.280 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 5.243188e-01 | 0.280 |
| R-HSA-5689880 | Ub-specific processing proteases | 5.243188e-01 | 0.280 |
| R-HSA-1226099 | Signaling by FGFR in disease | 5.278547e-01 | 0.277 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 5.298795e-01 | 0.276 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 5.298795e-01 | 0.276 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 5.321672e-01 | 0.274 |
| R-HSA-1980143 | Signaling by NOTCH1 | 5.364405e-01 | 0.270 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 5.406751e-01 | 0.267 |
| R-HSA-416482 | G alpha (12/13) signalling events | 5.448713e-01 | 0.264 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 5.516816e-01 | 0.258 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 5.531497e-01 | 0.257 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 5.612785e-01 | 0.251 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 5.652877e-01 | 0.248 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 5.692605e-01 | 0.245 |
| R-HSA-5617833 | Cilium Assembly | 5.701725e-01 | 0.244 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 5.731972e-01 | 0.242 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 5.753542e-01 | 0.240 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 5.770982e-01 | 0.239 |
| R-HSA-68877 | Mitotic Prometaphase | 5.779281e-01 | 0.238 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 5.809638e-01 | 0.236 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 5.847943e-01 | 0.233 |
| R-HSA-438064 | Post NMDA receptor activation events | 5.847943e-01 | 0.233 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 5.855818e-01 | 0.232 |
| R-HSA-9645723 | Diseases of programmed cell death | 5.885900e-01 | 0.230 |
| R-HSA-422475 | Axon guidance | 5.918239e-01 | 0.228 |
| R-HSA-1500931 | Cell-Cell communication | 5.941729e-01 | 0.226 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 5.997715e-01 | 0.222 |
| R-HSA-74752 | Signaling by Insulin receptor | 6.070576e-01 | 0.217 |
| R-HSA-391251 | Protein folding | 6.070576e-01 | 0.217 |
| R-HSA-9679506 | SARS-CoV Infections | 6.073851e-01 | 0.217 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 6.106512e-01 | 0.214 |
| R-HSA-2029481 | FCGR activation | 6.106512e-01 | 0.214 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 6.106512e-01 | 0.214 |
| R-HSA-5389840 | Mitochondrial translation elongation | 6.247017e-01 | 0.204 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 6.247017e-01 | 0.204 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 6.247017e-01 | 0.204 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 6.293598e-01 | 0.201 |
| R-HSA-5368286 | Mitochondrial translation initiation | 6.315370e-01 | 0.200 |
| R-HSA-3214847 | HATs acetylate histones | 6.349081e-01 | 0.197 |
| R-HSA-9614085 | FOXO-mediated transcription | 6.349081e-01 | 0.197 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 6.349081e-01 | 0.197 |
| R-HSA-70171 | Glycolysis | 6.382486e-01 | 0.195 |
| R-HSA-418990 | Adherens junctions interactions | 6.408697e-01 | 0.193 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 6.448387e-01 | 0.191 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 6.448387e-01 | 0.191 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 6.448387e-01 | 0.191 |
| R-HSA-1483255 | PI Metabolism | 6.448387e-01 | 0.191 |
| R-HSA-9675108 | Nervous system development | 6.476782e-01 | 0.189 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 6.480889e-01 | 0.188 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 6.513096e-01 | 0.186 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 6.513096e-01 | 0.186 |
| R-HSA-5696398 | Nucleotide Excision Repair | 6.576634e-01 | 0.182 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 6.587024e-01 | 0.181 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 6.630492e-01 | 0.178 |
| R-HSA-69239 | Synthesis of DNA | 6.639022e-01 | 0.178 |
| R-HSA-211000 | Gene Silencing by RNA | 6.639022e-01 | 0.178 |
| R-HSA-2672351 | Stimuli-sensing channels | 6.669791e-01 | 0.176 |
| R-HSA-5419276 | Mitochondrial translation termination | 6.700281e-01 | 0.174 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 6.700281e-01 | 0.174 |
| R-HSA-1483249 | Inositol phosphate metabolism | 6.790095e-01 | 0.168 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 6.790095e-01 | 0.168 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 6.848618e-01 | 0.164 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 6.906082e-01 | 0.161 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 6.934422e-01 | 0.159 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 6.934422e-01 | 0.159 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 6.934422e-01 | 0.159 |
| R-HSA-70326 | Glucose metabolism | 6.990331e-01 | 0.156 |
| R-HSA-9007101 | Rab regulation of trafficking | 6.990331e-01 | 0.156 |
| R-HSA-2980736 | Peptide hormone metabolism | 6.990331e-01 | 0.156 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 7.045227e-01 | 0.152 |
| R-HSA-3371556 | Cellular response to heat stress | 7.099129e-01 | 0.149 |
| R-HSA-6809371 | Formation of the cornified envelope | 7.178155e-01 | 0.144 |
| R-HSA-162909 | Host Interactions of HIV factors | 7.178155e-01 | 0.144 |
| R-HSA-69206 | G1/S Transition | 7.229648e-01 | 0.141 |
| R-HSA-194138 | Signaling by VEGF | 7.229648e-01 | 0.141 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 7.255043e-01 | 0.139 |
| R-HSA-1266738 | Developmental Biology | 7.260177e-01 | 0.139 |
| R-HSA-9824446 | Viral Infection Pathways | 7.278607e-01 | 0.138 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 7.305142e-01 | 0.136 |
| R-HSA-5576891 | Cardiac conduction | 7.402632e-01 | 0.131 |
| R-HSA-9909396 | Circadian clock | 7.426452e-01 | 0.129 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 7.512320e-01 | 0.124 |
| R-HSA-5368287 | Mitochondrial translation | 7.587225e-01 | 0.120 |
| R-HSA-9824443 | Parasitic Infection Pathways | 7.627711e-01 | 0.118 |
| R-HSA-9658195 | Leishmania infection | 7.627711e-01 | 0.118 |
| R-HSA-9664417 | Leishmania phagocytosis | 7.631300e-01 | 0.117 |
| R-HSA-9664407 | Parasite infection | 7.631300e-01 | 0.117 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 7.631300e-01 | 0.117 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 7.653036e-01 | 0.116 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 7.695916e-01 | 0.114 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 7.695916e-01 | 0.114 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 7.717064e-01 | 0.113 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 7.779357e-01 | 0.109 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 7.799743e-01 | 0.108 |
| R-HSA-69242 | S Phase | 7.819944e-01 | 0.107 |
| R-HSA-166520 | Signaling by NTRKs | 7.819944e-01 | 0.107 |
| R-HSA-1483257 | Phospholipid metabolism | 7.844722e-01 | 0.105 |
| R-HSA-195721 | Signaling by WNT | 7.888912e-01 | 0.103 |
| R-HSA-446652 | Interleukin-1 family signaling | 7.898922e-01 | 0.102 |
| R-HSA-69306 | DNA Replication | 7.918218e-01 | 0.101 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 7.937338e-01 | 0.100 |
| R-HSA-73887 | Death Receptor Signaling | 7.937338e-01 | 0.100 |
| R-HSA-162587 | HIV Life Cycle | 7.993659e-01 | 0.097 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 8.012091e-01 | 0.096 |
| R-HSA-877300 | Interferon gamma signaling | 8.030355e-01 | 0.095 |
| R-HSA-6798695 | Neutrophil degranulation | 8.147782e-01 | 0.089 |
| R-HSA-5619102 | SLC transporter disorders | 8.170590e-01 | 0.088 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 8.189382e-01 | 0.087 |
| R-HSA-72306 | tRNA processing | 8.236943e-01 | 0.084 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 8.269217e-01 | 0.083 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 8.285133e-01 | 0.082 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 8.285133e-01 | 0.082 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 8.300904e-01 | 0.081 |
| R-HSA-611105 | Respiratory electron transport | 8.362561e-01 | 0.078 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 8.527104e-01 | 0.069 |
| R-HSA-392499 | Metabolism of proteins | 8.610451e-01 | 0.065 |
| R-HSA-1280218 | Adaptive Immune System | 8.614634e-01 | 0.065 |
| R-HSA-168256 | Immune System | 8.630532e-01 | 0.064 |
| R-HSA-389948 | Co-inhibition by PD-1 | 8.664009e-01 | 0.062 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 8.688511e-01 | 0.061 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 8.700594e-01 | 0.060 |
| R-HSA-9640148 | Infection with Enterobacteria | 8.700594e-01 | 0.060 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 8.700594e-01 | 0.060 |
| R-HSA-6805567 | Keratinization | 8.747831e-01 | 0.058 |
| R-HSA-168249 | Innate Immune System | 8.759824e-01 | 0.058 |
| R-HSA-397014 | Muscle contraction | 8.815508e-01 | 0.055 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 8.815508e-01 | 0.055 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 8.947253e-01 | 0.048 |
| R-HSA-162906 | HIV Infection | 8.969220e-01 | 0.047 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 8.997496e-01 | 0.046 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 9.077785e-01 | 0.042 |
| R-HSA-157118 | Signaling by NOTCH | 9.086302e-01 | 0.042 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 9.143773e-01 | 0.039 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 9.212418e-01 | 0.036 |
| R-HSA-1643685 | Disease | 9.255146e-01 | 0.034 |
| R-HSA-416476 | G alpha (q) signalling events | 9.268830e-01 | 0.033 |
| R-HSA-9711123 | Cellular response to chemical stress | 9.295513e-01 | 0.032 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 9.358062e-01 | 0.029 |
| R-HSA-109582 | Hemostasis | 9.393279e-01 | 0.027 |
| R-HSA-199991 | Membrane Trafficking | 9.461844e-01 | 0.024 |
| R-HSA-597592 | Post-translational protein modification | 9.497062e-01 | 0.022 |
| R-HSA-5663205 | Infectious disease | 9.569011e-01 | 0.019 |
| R-HSA-112315 | Transmission across Chemical Synapses | 9.577852e-01 | 0.019 |
| R-HSA-211859 | Biological oxidations | 9.607217e-01 | 0.017 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.643132e-01 | 0.016 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.712152e-01 | 0.013 |
| R-HSA-500792 | GPCR ligand binding | 9.767539e-01 | 0.010 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.776431e-01 | 0.010 |
| R-HSA-388396 | GPCR downstream signalling | 9.779893e-01 | 0.010 |
| R-HSA-418594 | G alpha (i) signalling events | 9.809361e-01 | 0.008 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.816052e-01 | 0.008 |
| R-HSA-5653656 | Vesicle-mediated transport | 9.828534e-01 | 0.008 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.834389e-01 | 0.007 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.878545e-01 | 0.005 |
| R-HSA-372790 | Signaling by GPCR | 9.881034e-01 | 0.005 |
| R-HSA-112316 | Neuronal System | 9.892531e-01 | 0.005 |
| R-HSA-382551 | Transport of small molecules | 9.954084e-01 | 0.002 |
| R-HSA-556833 | Metabolism of lipids | 9.999915e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.824 | 0.168 | 2 | 0.701 |
CDC7 |
0.823 | 0.231 | 1 | 0.594 |
CLK3 |
0.823 | 0.148 | 1 | 0.489 |
MOS |
0.817 | 0.198 | 1 | 0.559 |
BMPR1B |
0.814 | 0.334 | 1 | 0.663 |
KIS |
0.813 | 0.073 | 1 | 0.374 |
PIM3 |
0.810 | 0.071 | -3 | 0.832 |
NDR2 |
0.809 | 0.066 | -3 | 0.846 |
GRK1 |
0.808 | 0.166 | -2 | 0.774 |
HIPK4 |
0.805 | 0.057 | 1 | 0.432 |
PRPK |
0.805 | -0.028 | -1 | 0.845 |
SRPK1 |
0.805 | 0.073 | -3 | 0.736 |
IKKB |
0.805 | -0.021 | -2 | 0.717 |
CHAK2 |
0.803 | 0.080 | -1 | 0.826 |
MTOR |
0.803 | -0.059 | 1 | 0.434 |
SKMLCK |
0.802 | 0.110 | -2 | 0.845 |
NLK |
0.802 | 0.008 | 1 | 0.473 |
RSK2 |
0.802 | 0.083 | -3 | 0.756 |
NDR1 |
0.799 | 0.021 | -3 | 0.828 |
AURC |
0.799 | 0.092 | -2 | 0.663 |
CAMK1B |
0.798 | 0.008 | -3 | 0.831 |
RAF1 |
0.798 | -0.036 | 1 | 0.505 |
DSTYK |
0.798 | -0.009 | 2 | 0.732 |
TBK1 |
0.798 | -0.107 | 1 | 0.407 |
GRK6 |
0.797 | 0.135 | 1 | 0.580 |
GCN2 |
0.797 | -0.125 | 2 | 0.682 |
BMPR2 |
0.796 | -0.045 | -2 | 0.824 |
ERK5 |
0.796 | -0.030 | 1 | 0.430 |
IKKA |
0.796 | 0.015 | -2 | 0.701 |
ATR |
0.796 | -0.046 | 1 | 0.462 |
CAMK2G |
0.796 | -0.042 | 2 | 0.692 |
MST4 |
0.796 | 0.014 | 2 | 0.729 |
GRK7 |
0.796 | 0.135 | 1 | 0.508 |
LATS2 |
0.796 | 0.034 | -5 | 0.762 |
DAPK2 |
0.795 | 0.105 | -3 | 0.838 |
TGFBR1 |
0.795 | 0.168 | -2 | 0.742 |
CLK2 |
0.795 | 0.119 | -3 | 0.737 |
CDKL1 |
0.795 | -0.003 | -3 | 0.778 |
PRKD1 |
0.795 | 0.012 | -3 | 0.814 |
PRKD2 |
0.795 | 0.039 | -3 | 0.760 |
IKKE |
0.795 | -0.109 | 1 | 0.406 |
CDK1 |
0.795 | 0.040 | 1 | 0.391 |
GRK5 |
0.795 | 0.042 | -3 | 0.830 |
ACVR2B |
0.794 | 0.235 | -2 | 0.734 |
TGFBR2 |
0.794 | 0.020 | -2 | 0.732 |
BMPR1A |
0.794 | 0.243 | 1 | 0.642 |
PKN3 |
0.793 | -0.033 | -3 | 0.808 |
CAMLCK |
0.793 | 0.030 | -2 | 0.829 |
HIPK2 |
0.793 | 0.036 | 1 | 0.330 |
PIM1 |
0.793 | 0.029 | -3 | 0.765 |
AMPKA1 |
0.793 | 0.022 | -3 | 0.831 |
NEK6 |
0.792 | -0.050 | -2 | 0.799 |
PDHK4 |
0.792 | -0.205 | 1 | 0.493 |
NIK |
0.792 | -0.025 | -3 | 0.856 |
P90RSK |
0.792 | 0.036 | -3 | 0.763 |
MAPKAPK2 |
0.792 | 0.046 | -3 | 0.730 |
PKN2 |
0.792 | 0.005 | -3 | 0.808 |
NUAK2 |
0.792 | 0.010 | -3 | 0.810 |
ULK2 |
0.792 | -0.152 | 2 | 0.657 |
PKCD |
0.791 | 0.002 | 2 | 0.645 |
RSK3 |
0.791 | 0.013 | -3 | 0.748 |
SRPK2 |
0.791 | 0.047 | -3 | 0.655 |
ALK4 |
0.791 | 0.139 | -2 | 0.775 |
DYRK2 |
0.790 | -0.002 | 1 | 0.377 |
RSK4 |
0.790 | 0.089 | -3 | 0.736 |
WNK1 |
0.790 | -0.062 | -2 | 0.853 |
PKACG |
0.790 | 0.019 | -2 | 0.732 |
LATS1 |
0.790 | 0.082 | -3 | 0.875 |
CDKL5 |
0.789 | -0.020 | -3 | 0.771 |
CDK8 |
0.789 | -0.037 | 1 | 0.368 |
MAPKAPK3 |
0.789 | 0.002 | -3 | 0.764 |
ACVR2A |
0.789 | 0.201 | -2 | 0.716 |
MARK4 |
0.788 | -0.017 | 4 | 0.822 |
MLK1 |
0.788 | -0.076 | 2 | 0.667 |
CDK19 |
0.788 | -0.027 | 1 | 0.343 |
RIPK3 |
0.788 | -0.073 | 3 | 0.671 |
CDK7 |
0.788 | -0.016 | 1 | 0.383 |
P70S6KB |
0.787 | 0.014 | -3 | 0.771 |
HUNK |
0.787 | -0.061 | 2 | 0.670 |
JNK2 |
0.787 | 0.008 | 1 | 0.353 |
HIPK1 |
0.787 | 0.034 | 1 | 0.387 |
GRK2 |
0.787 | 0.207 | -2 | 0.688 |
PDHK1 |
0.787 | -0.211 | 1 | 0.465 |
AMPKA2 |
0.787 | 0.013 | -3 | 0.802 |
DLK |
0.786 | 0.022 | 1 | 0.518 |
DRAK1 |
0.786 | 0.237 | 1 | 0.641 |
PRKX |
0.786 | 0.091 | -3 | 0.671 |
PKACB |
0.786 | 0.064 | -2 | 0.677 |
ICK |
0.786 | -0.016 | -3 | 0.819 |
SRPK3 |
0.786 | 0.052 | -3 | 0.698 |
TSSK2 |
0.785 | -0.007 | -5 | 0.770 |
CDK13 |
0.785 | -0.013 | 1 | 0.360 |
NEK7 |
0.785 | -0.137 | -3 | 0.807 |
CDK5 |
0.785 | 0.005 | 1 | 0.392 |
JNK3 |
0.784 | -0.007 | 1 | 0.367 |
CDK18 |
0.784 | -0.010 | 1 | 0.339 |
ALK2 |
0.784 | 0.110 | -2 | 0.757 |
P38G |
0.784 | -0.003 | 1 | 0.314 |
MLK3 |
0.783 | -0.019 | 2 | 0.606 |
PLK1 |
0.783 | 0.073 | -2 | 0.743 |
CLK4 |
0.783 | 0.037 | -3 | 0.740 |
CAMK2B |
0.783 | 0.020 | 2 | 0.658 |
TSSK1 |
0.783 | -0.014 | -3 | 0.852 |
CDK3 |
0.783 | 0.023 | 1 | 0.335 |
PAK1 |
0.783 | -0.012 | -2 | 0.775 |
AURB |
0.783 | 0.050 | -2 | 0.661 |
CK2A2 |
0.782 | 0.178 | 1 | 0.631 |
GRK4 |
0.782 | -0.029 | -2 | 0.797 |
CAMK2D |
0.782 | -0.061 | -3 | 0.812 |
CLK1 |
0.782 | 0.037 | -3 | 0.717 |
AURA |
0.781 | 0.060 | -2 | 0.637 |
PKCB |
0.781 | -0.007 | 2 | 0.595 |
FAM20C |
0.781 | -0.009 | 2 | 0.517 |
QSK |
0.781 | 0.021 | 4 | 0.808 |
CAMK2A |
0.781 | 0.029 | 2 | 0.681 |
ULK1 |
0.781 | -0.153 | -3 | 0.792 |
MSK1 |
0.780 | 0.041 | -3 | 0.728 |
MLK2 |
0.780 | -0.111 | 2 | 0.692 |
PKR |
0.780 | -0.042 | 1 | 0.476 |
IRE1 |
0.779 | -0.086 | 1 | 0.430 |
CDK12 |
0.779 | -0.015 | 1 | 0.343 |
PKCG |
0.779 | -0.013 | 2 | 0.596 |
MASTL |
0.779 | -0.171 | -2 | 0.766 |
BRSK1 |
0.778 | 0.024 | -3 | 0.770 |
CDK17 |
0.778 | -0.022 | 1 | 0.323 |
PKG2 |
0.778 | 0.029 | -2 | 0.677 |
PKCA |
0.778 | -0.013 | 2 | 0.597 |
WNK3 |
0.778 | -0.215 | 1 | 0.441 |
MNK2 |
0.778 | -0.015 | -2 | 0.778 |
P38B |
0.778 | -0.015 | 1 | 0.338 |
NEK9 |
0.778 | -0.159 | 2 | 0.700 |
RIPK1 |
0.778 | -0.143 | 1 | 0.460 |
MSK2 |
0.778 | -0.015 | -3 | 0.720 |
BCKDK |
0.777 | -0.172 | -1 | 0.746 |
ERK1 |
0.777 | -0.027 | 1 | 0.328 |
ATM |
0.777 | -0.074 | 1 | 0.425 |
ANKRD3 |
0.777 | -0.120 | 1 | 0.489 |
CAMK4 |
0.777 | -0.062 | -3 | 0.787 |
CHAK1 |
0.777 | -0.050 | 2 | 0.701 |
DYRK4 |
0.777 | -0.007 | 1 | 0.345 |
MNK1 |
0.777 | -0.001 | -2 | 0.790 |
PAK3 |
0.777 | -0.056 | -2 | 0.770 |
MYLK4 |
0.777 | 0.047 | -2 | 0.770 |
NIM1 |
0.777 | -0.099 | 3 | 0.725 |
YSK4 |
0.776 | -0.076 | 1 | 0.447 |
DYRK1B |
0.776 | 0.005 | 1 | 0.365 |
P38A |
0.776 | -0.031 | 1 | 0.375 |
PASK |
0.776 | 0.146 | -3 | 0.838 |
AKT2 |
0.776 | 0.026 | -3 | 0.660 |
TTBK2 |
0.776 | -0.148 | 2 | 0.582 |
CK2A1 |
0.775 | 0.180 | 1 | 0.637 |
PRKD3 |
0.775 | -0.025 | -3 | 0.714 |
P38D |
0.775 | -0.004 | 1 | 0.290 |
MEK1 |
0.775 | -0.036 | 2 | 0.722 |
GRK3 |
0.774 | 0.161 | -2 | 0.654 |
IRE2 |
0.774 | -0.082 | 2 | 0.619 |
MARK3 |
0.774 | 0.035 | 4 | 0.765 |
SGK3 |
0.774 | -0.002 | -3 | 0.743 |
CDK2 |
0.774 | -0.010 | 1 | 0.443 |
PIM2 |
0.774 | 0.025 | -3 | 0.720 |
PAK6 |
0.774 | -0.004 | -2 | 0.706 |
PKCZ |
0.774 | -0.052 | 2 | 0.648 |
MLK4 |
0.773 | -0.035 | 2 | 0.580 |
SMG1 |
0.773 | -0.070 | 1 | 0.412 |
TLK2 |
0.773 | -0.069 | 1 | 0.440 |
PRP4 |
0.773 | 0.027 | -3 | 0.804 |
QIK |
0.772 | -0.063 | -3 | 0.793 |
DYRK1A |
0.772 | -0.018 | 1 | 0.399 |
MELK |
0.772 | -0.065 | -3 | 0.783 |
PAK2 |
0.772 | -0.039 | -2 | 0.760 |
VRK2 |
0.772 | -0.170 | 1 | 0.481 |
CDK10 |
0.772 | 0.016 | 1 | 0.366 |
HIPK3 |
0.772 | -0.015 | 1 | 0.360 |
PKCH |
0.772 | -0.045 | 2 | 0.586 |
MST3 |
0.771 | 0.045 | 2 | 0.710 |
NUAK1 |
0.771 | -0.061 | -3 | 0.771 |
PHKG1 |
0.771 | -0.085 | -3 | 0.806 |
MPSK1 |
0.771 | 0.002 | 1 | 0.434 |
SIK |
0.771 | -0.028 | -3 | 0.734 |
CDK9 |
0.771 | -0.052 | 1 | 0.358 |
NEK2 |
0.770 | -0.124 | 2 | 0.701 |
DNAPK |
0.770 | -0.084 | 1 | 0.348 |
CDK14 |
0.769 | -0.022 | 1 | 0.370 |
BRSK2 |
0.769 | -0.056 | -3 | 0.790 |
ERK2 |
0.769 | -0.053 | 1 | 0.359 |
MARK2 |
0.769 | 0.002 | 4 | 0.732 |
PKACA |
0.769 | 0.037 | -2 | 0.627 |
CDK16 |
0.769 | -0.020 | 1 | 0.326 |
DYRK3 |
0.768 | -0.000 | 1 | 0.382 |
PLK3 |
0.768 | -0.069 | 2 | 0.643 |
DCAMKL1 |
0.767 | -0.032 | -3 | 0.771 |
TAO3 |
0.767 | 0.009 | 1 | 0.463 |
AKT1 |
0.766 | 0.017 | -3 | 0.683 |
JNK1 |
0.766 | -0.012 | 1 | 0.362 |
MEKK3 |
0.766 | -0.055 | 1 | 0.475 |
MARK1 |
0.765 | 0.002 | 4 | 0.785 |
CHK1 |
0.765 | -0.068 | -3 | 0.822 |
DAPK3 |
0.765 | 0.072 | -3 | 0.778 |
GCK |
0.765 | 0.102 | 1 | 0.506 |
SSTK |
0.764 | -0.027 | 4 | 0.787 |
PLK4 |
0.764 | -0.125 | 2 | 0.531 |
CK1E |
0.764 | 0.009 | -3 | 0.484 |
DAPK1 |
0.764 | 0.106 | -3 | 0.750 |
CAMK1G |
0.764 | -0.043 | -3 | 0.723 |
ZAK |
0.763 | -0.103 | 1 | 0.449 |
BRAF |
0.763 | -0.073 | -4 | 0.822 |
GAK |
0.762 | 0.006 | 1 | 0.497 |
PINK1 |
0.762 | -0.107 | 1 | 0.470 |
SNRK |
0.762 | -0.136 | 2 | 0.590 |
MEK5 |
0.762 | -0.136 | 2 | 0.698 |
SMMLCK |
0.762 | 0.009 | -3 | 0.783 |
MEKK2 |
0.762 | -0.097 | 2 | 0.669 |
MEKK1 |
0.762 | -0.146 | 1 | 0.441 |
PERK |
0.762 | -0.138 | -2 | 0.775 |
NEK5 |
0.761 | -0.119 | 1 | 0.444 |
PKCT |
0.760 | -0.062 | 2 | 0.592 |
LKB1 |
0.760 | -0.001 | -3 | 0.813 |
MAK |
0.760 | 0.024 | -2 | 0.705 |
HPK1 |
0.760 | 0.071 | 1 | 0.491 |
IRAK4 |
0.759 | -0.135 | 1 | 0.414 |
WNK4 |
0.758 | -0.143 | -2 | 0.844 |
PKCE |
0.758 | 0.008 | 2 | 0.591 |
BUB1 |
0.758 | 0.061 | -5 | 0.713 |
TNIK |
0.758 | 0.019 | 3 | 0.870 |
ERK7 |
0.758 | -0.021 | 2 | 0.456 |
CDK6 |
0.758 | -0.013 | 1 | 0.341 |
GSK3A |
0.757 | -0.008 | 4 | 0.408 |
CK1D |
0.757 | 0.011 | -3 | 0.435 |
P70S6K |
0.757 | -0.028 | -3 | 0.674 |
DCAMKL2 |
0.757 | -0.071 | -3 | 0.786 |
TLK1 |
0.757 | -0.133 | -2 | 0.768 |
NEK11 |
0.757 | -0.080 | 1 | 0.475 |
KHS2 |
0.756 | 0.079 | 1 | 0.468 |
HRI |
0.756 | -0.195 | -2 | 0.781 |
AKT3 |
0.756 | 0.022 | -3 | 0.608 |
PHKG2 |
0.756 | -0.087 | -3 | 0.761 |
NEK8 |
0.756 | -0.104 | 2 | 0.688 |
MINK |
0.755 | -0.005 | 1 | 0.450 |
TAO2 |
0.755 | -0.062 | 2 | 0.713 |
PDK1 |
0.755 | -0.080 | 1 | 0.446 |
CDK4 |
0.755 | -0.021 | 1 | 0.336 |
CAMKK1 |
0.755 | -0.082 | -2 | 0.734 |
HGK |
0.755 | -0.020 | 3 | 0.861 |
PAK5 |
0.754 | -0.028 | -2 | 0.630 |
PKCI |
0.754 | -0.047 | 2 | 0.617 |
MAPKAPK5 |
0.754 | -0.116 | -3 | 0.682 |
CAMK1D |
0.754 | -0.023 | -3 | 0.664 |
MOK |
0.753 | 0.016 | 1 | 0.375 |
KHS1 |
0.753 | 0.024 | 1 | 0.437 |
EEF2K |
0.753 | -0.006 | 3 | 0.853 |
GSK3B |
0.753 | -0.029 | 4 | 0.395 |
MAP3K15 |
0.752 | -0.072 | 1 | 0.418 |
CAMKK2 |
0.752 | -0.064 | -2 | 0.724 |
MST2 |
0.752 | -0.041 | 1 | 0.477 |
ROCK2 |
0.752 | 0.021 | -3 | 0.772 |
CK1A2 |
0.752 | -0.001 | -3 | 0.429 |
PDHK3_TYR |
0.752 | 0.230 | 4 | 0.869 |
SGK1 |
0.751 | 0.015 | -3 | 0.590 |
TAK1 |
0.751 | -0.045 | 1 | 0.489 |
PAK4 |
0.750 | -0.027 | -2 | 0.635 |
PLK2 |
0.748 | -0.028 | -3 | 0.768 |
MRCKB |
0.748 | -0.001 | -3 | 0.711 |
TTBK1 |
0.748 | -0.162 | 2 | 0.511 |
CK1G1 |
0.748 | -0.077 | -3 | 0.509 |
MRCKA |
0.748 | 0.001 | -3 | 0.735 |
MEKK6 |
0.747 | -0.115 | 1 | 0.420 |
NEK4 |
0.747 | -0.132 | 1 | 0.422 |
LRRK2 |
0.747 | -0.096 | 2 | 0.724 |
LOK |
0.747 | -0.066 | -2 | 0.715 |
NEK1 |
0.746 | -0.096 | 1 | 0.424 |
PKN1 |
0.746 | -0.057 | -3 | 0.687 |
SLK |
0.745 | -0.055 | -2 | 0.651 |
CHK2 |
0.745 | -0.013 | -3 | 0.606 |
PDHK4_TYR |
0.745 | 0.160 | 2 | 0.758 |
MST1 |
0.745 | -0.062 | 1 | 0.454 |
PBK |
0.744 | -0.047 | 1 | 0.410 |
VRK1 |
0.743 | -0.120 | 2 | 0.688 |
IRAK1 |
0.742 | -0.227 | -1 | 0.742 |
DMPK1 |
0.742 | 0.027 | -3 | 0.734 |
OSR1 |
0.741 | 0.001 | 2 | 0.677 |
BMPR2_TYR |
0.741 | 0.187 | -1 | 0.866 |
YSK1 |
0.741 | -0.088 | 2 | 0.683 |
HASPIN |
0.741 | -0.014 | -1 | 0.682 |
CAMK1A |
0.740 | -0.036 | -3 | 0.636 |
STK33 |
0.740 | -0.114 | 2 | 0.512 |
TESK1_TYR |
0.740 | 0.035 | 3 | 0.842 |
MAP2K6_TYR |
0.739 | 0.112 | -1 | 0.862 |
MAP2K4_TYR |
0.738 | 0.063 | -1 | 0.855 |
PDHK1_TYR |
0.738 | 0.099 | -1 | 0.872 |
TXK |
0.738 | 0.260 | 1 | 0.609 |
CRIK |
0.735 | 0.007 | -3 | 0.691 |
ROCK1 |
0.735 | -0.006 | -3 | 0.729 |
SBK |
0.734 | -0.022 | -3 | 0.548 |
LIMK2_TYR |
0.734 | -0.003 | -3 | 0.879 |
MEK2 |
0.734 | -0.177 | 2 | 0.698 |
PKMYT1_TYR |
0.733 | -0.048 | 3 | 0.794 |
MYO3B |
0.732 | -0.036 | 2 | 0.715 |
MAP2K7_TYR |
0.732 | -0.124 | 2 | 0.740 |
TTK |
0.732 | -0.044 | -2 | 0.758 |
PKG1 |
0.732 | -0.037 | -2 | 0.598 |
PINK1_TYR |
0.732 | -0.072 | 1 | 0.492 |
ASK1 |
0.731 | -0.107 | 1 | 0.416 |
BIKE |
0.730 | -0.050 | 1 | 0.404 |
EPHA6 |
0.730 | 0.040 | -1 | 0.843 |
RIPK2 |
0.730 | -0.224 | 1 | 0.419 |
MYO3A |
0.728 | -0.065 | 1 | 0.439 |
ALPHAK3 |
0.727 | -0.050 | -1 | 0.759 |
CK1A |
0.727 | 0.041 | -3 | 0.349 |
EPHB4 |
0.725 | 0.020 | -1 | 0.813 |
YANK3 |
0.725 | -0.061 | 2 | 0.324 |
TAO1 |
0.724 | -0.094 | 1 | 0.385 |
LCK |
0.724 | 0.053 | -1 | 0.842 |
NEK3 |
0.723 | -0.198 | 1 | 0.373 |
RET |
0.723 | -0.151 | 1 | 0.419 |
ITK |
0.723 | 0.095 | -1 | 0.800 |
FGR |
0.723 | 0.006 | 1 | 0.503 |
LIMK1_TYR |
0.722 | -0.134 | 2 | 0.734 |
ABL2 |
0.722 | -0.017 | -1 | 0.780 |
TYRO3 |
0.722 | -0.067 | 3 | 0.748 |
BLK |
0.721 | 0.042 | -1 | 0.839 |
YES1 |
0.721 | -0.013 | -1 | 0.833 |
SRMS |
0.721 | 0.071 | 1 | 0.550 |
ROS1 |
0.721 | -0.075 | 3 | 0.714 |
TYK2 |
0.720 | -0.184 | 1 | 0.407 |
MST1R |
0.720 | -0.140 | 3 | 0.755 |
FER |
0.720 | -0.011 | 1 | 0.525 |
CSF1R |
0.719 | -0.088 | 3 | 0.726 |
AAK1 |
0.719 | -0.027 | 1 | 0.332 |
JAK3 |
0.719 | -0.079 | 1 | 0.422 |
EPHA4 |
0.718 | 0.008 | 2 | 0.650 |
HCK |
0.718 | -0.015 | -1 | 0.835 |
JAK2 |
0.717 | -0.172 | 1 | 0.401 |
INSRR |
0.717 | 0.002 | 3 | 0.677 |
BMX |
0.717 | 0.075 | -1 | 0.722 |
NEK10_TYR |
0.716 | -0.093 | 1 | 0.356 |
FYN |
0.715 | 0.061 | -1 | 0.826 |
ABL1 |
0.715 | -0.060 | -1 | 0.771 |
EPHB1 |
0.715 | 0.023 | 1 | 0.522 |
JAK1 |
0.715 | -0.059 | 1 | 0.374 |
STLK3 |
0.714 | -0.135 | 1 | 0.421 |
PTK2 |
0.714 | 0.171 | -1 | 0.801 |
MERTK |
0.713 | 0.020 | 3 | 0.699 |
TNK2 |
0.713 | -0.074 | 3 | 0.681 |
WEE1_TYR |
0.712 | -0.029 | -1 | 0.734 |
KIT |
0.712 | -0.084 | 3 | 0.721 |
EPHB2 |
0.712 | -0.003 | -1 | 0.794 |
DDR1 |
0.711 | -0.181 | 4 | 0.773 |
TEC |
0.711 | 0.020 | -1 | 0.718 |
TNNI3K_TYR |
0.710 | -0.098 | 1 | 0.411 |
PDGFRB |
0.710 | -0.127 | 3 | 0.748 |
EPHB3 |
0.710 | -0.049 | -1 | 0.798 |
MET |
0.710 | -0.036 | 3 | 0.719 |
FGFR2 |
0.709 | -0.151 | 3 | 0.727 |
SYK |
0.709 | 0.122 | -1 | 0.784 |
PTK2B |
0.709 | 0.100 | -1 | 0.749 |
FLT3 |
0.709 | -0.150 | 3 | 0.748 |
KDR |
0.708 | -0.116 | 3 | 0.693 |
AXL |
0.708 | -0.079 | 3 | 0.699 |
TNK1 |
0.707 | -0.140 | 3 | 0.719 |
BTK |
0.707 | -0.083 | -1 | 0.761 |
FRK |
0.705 | -0.047 | -1 | 0.834 |
EPHA7 |
0.705 | -0.019 | 2 | 0.646 |
ALK |
0.705 | -0.069 | 3 | 0.657 |
FLT1 |
0.704 | -0.080 | -1 | 0.815 |
TEK |
0.703 | -0.158 | 3 | 0.655 |
PTK6 |
0.702 | -0.134 | -1 | 0.717 |
EGFR |
0.702 | -0.052 | 1 | 0.389 |
LYN |
0.702 | -0.055 | 3 | 0.643 |
FGFR1 |
0.701 | -0.194 | 3 | 0.698 |
EPHA3 |
0.701 | -0.070 | 2 | 0.625 |
PDGFRA |
0.701 | -0.206 | 3 | 0.749 |
ERBB2 |
0.700 | -0.110 | 1 | 0.439 |
SRC |
0.700 | -0.021 | -1 | 0.806 |
LTK |
0.700 | -0.118 | 3 | 0.673 |
FGFR3 |
0.699 | -0.130 | 3 | 0.693 |
EPHA8 |
0.699 | -0.011 | -1 | 0.794 |
NTRK1 |
0.699 | -0.109 | -1 | 0.776 |
EPHA1 |
0.699 | -0.102 | 3 | 0.699 |
EPHA5 |
0.699 | -0.030 | 2 | 0.629 |
INSR |
0.698 | -0.092 | 3 | 0.650 |
MATK |
0.697 | -0.073 | -1 | 0.700 |
NTRK3 |
0.696 | -0.071 | -1 | 0.732 |
DDR2 |
0.695 | -0.096 | 3 | 0.667 |
CK1G3 |
0.693 | -0.059 | -3 | 0.305 |
NTRK2 |
0.692 | -0.153 | 3 | 0.676 |
EPHA2 |
0.692 | -0.002 | -1 | 0.762 |
FLT4 |
0.692 | -0.186 | 3 | 0.668 |
YANK2 |
0.691 | -0.076 | 2 | 0.335 |
ERBB4 |
0.691 | -0.008 | 1 | 0.451 |
FGFR4 |
0.690 | -0.105 | -1 | 0.743 |
CSK |
0.689 | -0.123 | 2 | 0.651 |
ZAP70 |
0.688 | 0.014 | -1 | 0.704 |
MUSK |
0.687 | -0.101 | 1 | 0.369 |
IGF1R |
0.685 | -0.059 | 3 | 0.580 |
CK1G2 |
0.680 | -0.027 | -3 | 0.410 |
FES |
0.678 | 0.010 | -1 | 0.689 |