Motif 865 (n=173)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A096LP49 | CCDC187 | S1027 | ochoa | Coiled-coil domain-containing protein 187 | None |
| A0A0C4DFX4 | None | S2778 | ochoa | Snf2 related CREBBP activator protein | None |
| A0A0J9YX86 | GOLGA8Q | S77 | ochoa | Golgin A8 family member Q | None |
| A6NE02 | BTBD17 | S46 | ochoa | BTB/POZ domain-containing protein 17 (Galectin-3-binding protein-like) | None |
| A6NMD2 | GOLGA8J | S77 | ochoa | Golgin subfamily A member 8J | None |
| E9PAV3 | NACA | S765 | ochoa | Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC) | Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250|UniProtKB:P70670}. |
| H3BQL2 | GOLGA8T | S77 | ochoa | Golgin subfamily A member 8T | None |
| H3BSY2 | GOLGA8M | S77 | ochoa | Golgin subfamily A member 8M | None |
| I6L899 | GOLGA8R | S77 | ochoa | Golgin subfamily A member 8R | None |
| O15417 | TNRC18 | S416 | ochoa | Trinucleotide repeat-containing gene 18 protein (Long CAG trinucleotide repeat-containing gene 79 protein) | None |
| O15534 | PER1 | S811 | ochoa | Period circadian protein homolog 1 (hPER1) (Circadian clock protein PERIOD 1) (Circadian pacemaker protein Rigui) | Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Regulates circadian target genes expression at post-transcriptional levels, but may not be required for the repression at transcriptional level. Controls PER2 protein decay. Represses CRY2 preventing its repression on CLOCK/BMAL1 target genes such as FXYD5 and SCNN1A in kidney and PPARA in liver. Besides its involvement in the maintenance of the circadian clock, has an important function in the regulation of several processes. Participates in the repression of glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) by BMAL1:CLOCK. Plays a role in the modulation of the neuroinflammatory state via the regulation of inflammatory mediators release, such as CCL2 and IL6. In spinal astrocytes, negatively regulates the MAPK14/p38 and MAPK8/JNK MAPK cascades as well as the subsequent activation of NFkappaB. Coordinately regulates the expression of multiple genes that are involved in the regulation of renal sodium reabsorption. Can act as gene expression activator in a gene and tissue specific manner, in kidney enhances WNK1 and SLC12A3 expression in collaboration with CLOCK. Modulates hair follicle cycling. Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1. {ECO:0000269|PubMed:24005054}. |
| O43166 | SIPA1L1 | S93 | ochoa | Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) | Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}. |
| O43290 | SART1 | S112 | ochoa | U4/U6.U5 tri-snRNP-associated protein 1 (SNU66 homolog) (hSnu66) (Squamous cell carcinoma antigen recognized by T-cells 1) (SART-1) (hSART-1) (U4/U6.U5 tri-snRNP-associated 110 kDa protein) (allergen Hom s 1) | Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA. {ECO:0000269|PubMed:11350945, ECO:0000269|PubMed:25092792}. |
| O60469 | DSCAM | S1934 | ochoa | Cell adhesion molecule DSCAM (CHD2) (Down syndrome cell adhesion molecule) | Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies (PubMed:10925149). Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. Might also collaborate with UNC5C in NTN1-mediated axon repulsion independently of DCC (By similarity). In spinal cord development plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding (PubMed:18585357, PubMed:19196994). Mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38 (PubMed:18585357, PubMed:19196994). Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions (By similarity). {ECO:0000250|UniProtKB:F1NY98, ECO:0000250|UniProtKB:Q9ERC8, ECO:0000269|PubMed:10925149, ECO:0000269|PubMed:18585357, ECO:0000269|PubMed:19196994}. |
| O75052 | NOS1AP | S249 | ochoa | Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C-terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein) | Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 (By similarity). In kidney podocytes, plays a role in podosomes and filopodia formation through CDC42 activation (PubMed:33523862). {ECO:0000250|UniProtKB:O54960, ECO:0000269|PubMed:33523862}. |
| O75533 | SF3B1 | S332 | ochoa | Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B1 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). {ECO:0000250|UniProtKB:Q99NB9, ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}. |
| O75643 | SNRNP200 | S457 | ochoa | U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.4.13) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog) (U5 snRNP-specific 200 kDa protein) (U5-200KD) | Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome (PubMed:35241646). Plays a role in pre-mRNA splicing as a core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:28502770, PubMed:28781166, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30315277, PubMed:30705154, PubMed:30728453). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. {ECO:0000269|PubMed:16723661, ECO:0000269|PubMed:23045696, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:30728453, ECO:0000269|PubMed:35241646, ECO:0000269|PubMed:8670905, ECO:0000269|PubMed:9539711, ECO:0000305|PubMed:33509932}. |
| O75665 | OFD1 | S745 | ochoa | Centriole and centriolar satellite protein OFD1 (Oral-facial-digital syndrome 1 protein) (Protein 71-7A) | Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164 (By similarity). Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis (PubMed:33934390). Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation (By similarity). {ECO:0000250|UniProtKB:Q80Z25, ECO:0000269|PubMed:33934390}. |
| O94804 | STK10 | S450 | ochoa | Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase) | Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. {ECO:0000269|PubMed:11903060, ECO:0000269|PubMed:12639966, ECO:0000269|PubMed:19255442}. |
| O95977 | S1PR4 | S346 | ochoa | Sphingosine 1-phosphate receptor 4 (S1P receptor 4) (S1P4) (Endothelial differentiation G-protein coupled receptor 6) (Sphingosine 1-phosphate receptor Edg-6) (S1P receptor Edg-6) | Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes. {ECO:0000269|PubMed:10679247, ECO:0000269|PubMed:10753843}. |
| P04049 | RAF1 | S497 | ochoa|psp | RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) | Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}. |
| P05181 | CYP2E1 | S247 | psp | Cytochrome P450 2E1 (EC 1.14.14.1) (4-nitrophenol 2-hydroxylase) (EC 1.14.13.n7) (CYPIIE1) (Cytochrome P450-J) | A cytochrome P450 monooxygenase involved in the metabolism of fatty acids (PubMed:10553002, PubMed:18577768). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:10553002, PubMed:18577768). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids (PubMed:10553002, PubMed:18577768). May be involved in the oxidative metabolism of xenobiotics (Probable). {ECO:0000269|PubMed:10553002, ECO:0000269|PubMed:18577768, ECO:0000305|PubMed:9348445}. |
| P07919 | UQCRH | S61 | ochoa | Cytochrome b-c1 complex subunit 6, mitochondrial (Complex III subunit 6) (Complex III subunit VIII) (Cytochrome c1 non-heme 11 kDa protein) (Mitochondrial hinge protein) (Ubiquinol-cytochrome c reductase complex 11 kDa protein) | Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. {ECO:0000269|PubMed:34750991}. |
| P0CJ92 | GOLGA8H | S77 | ochoa | Golgin subfamily A member 8H | None |
| P10398 | ARAF | S458 | ochoa | Serine/threonine-protein kinase A-Raf (EC 2.7.11.1) (Proto-oncogene A-Raf) (Proto-oncogene A-Raf-1) (Proto-oncogene Pks) | Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade. Phosphorylates PFKFB2 (PubMed:36402789). {ECO:0000269|PubMed:22609986, ECO:0000269|PubMed:36402789}.; FUNCTION: [Isoform 2]: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation. {ECO:0000269|PubMed:22609986}. |
| P11137 | MAP2 | S736 | ochoa | Microtubule-associated protein 2 (MAP-2) | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
| P15056 | BRAF | S605 | ochoa|psp | Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) | Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). Phosphorylates PFKFB2 (PubMed:36402789). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179). {ECO:0000269|PubMed:1508179, ECO:0000269|PubMed:21441910, ECO:0000269|PubMed:29433126, ECO:0000269|PubMed:36402789, ECO:0000305}. |
| P15735 | PHKG2 | S269 | ochoa | Phosphorylase b kinase gamma catalytic chain, liver/testis isoform (PHK-gamma-LT) (PHK-gamma-T) (EC 2.7.11.19) (PSK-C3) (Phosphorylase kinase subunit gamma-2) | Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. May regulate glycogeneolysis in the testis. In vitro, phosphorylates PYGM (PubMed:35549678). {ECO:0000250|UniProtKB:P31325, ECO:0000269|PubMed:10487978, ECO:0000269|PubMed:35549678}. |
| P17661 | DES | S92 | ochoa | Desmin | Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity (PubMed:25358400). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed:24200904, PubMed:25394388, PubMed:26724190). May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Required for nuclear membrane integrity, via anchoring at the cell tip and nuclear envelope, resulting in maintenance of microtubule-derived intracellular mechanical forces (By similarity). Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin (By similarity). {ECO:0000250|UniProtKB:P31001, ECO:0000269|PubMed:24200904, ECO:0000269|PubMed:25394388, ECO:0000269|PubMed:26724190, ECO:0000303|PubMed:25358400}. |
| P23246 | SFPQ | S374 | ochoa | Splicing factor, proline- and glutamine-rich (100 kDa DNA-pairing protein) (hPOMp100) (DNA-binding p52/p100 complex, 100 kDa subunit) (Polypyrimidine tract-binding protein-associated-splicing factor) (PSF) (PTB-associated-splicing factor) | DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphorylation is proposed to lead to release from THRAP3 allowing binding to pre-mRNA splicing regulatotry elements which represses exon inclusion. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. May be involved in a pre-mRNA coupled splicing and polyadenylation process as component of a snRNP-free complex with SNRPA/U1A. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. SFPQ may be involved in homologous DNA pairing; in vitro, promotes the invasion of ssDNA between a duplex DNA and produces a D-loop formation. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1; in vitro, stimulates dissociation of TOP1 from DNA after cleavage and enhances its jumping between separate DNA helices. The SFPQ-NONO heteromer binds DNA (PubMed:25765647). The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends; in vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. SFPQ is involved in transcriptional regulation. Functions as a transcriptional activator (PubMed:25765647). Transcriptional repression is mediated by an interaction of SFPQ with SIN3A and subsequent recruitment of histone deacetylases (HDACs). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. SFPQ isoform Long binds to the DNA binding domains (DBD) of nuclear hormone receptors, like RXRA and probably THRA, and acts as a transcriptional corepressor in absence of hormone ligands. Binds the DNA sequence 5'-CTGAGTC-3' in the insulin-like growth factor response element (IGFRE) and inhibits IGF1-stimulated transcriptional activity. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation (By similarity). Required for the assembly of nuclear speckles (PubMed:25765647). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000250|UniProtKB:Q8VIJ6, ECO:0000269|PubMed:10847580, ECO:0000269|PubMed:10858305, ECO:0000269|PubMed:10931916, ECO:0000269|PubMed:11259580, ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:11897684, ECO:0000269|PubMed:15590677, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:25765647, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:8045264, ECO:0000269|PubMed:8449401}. |
| P25054 | APC | S246 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P25789 | PSMA4 | S173 | ochoa | Proteasome subunit alpha type-4 (Macropain subunit C9) (Multicatalytic endopeptidase complex subunit C9) (Proteasome component C9) (Proteasome subunit L) (Proteasome subunit alpha-3) (alpha-3) | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. |
| P26232 | CTNNA2 | S321 | ochoa | Catenin alpha-2 (Alpha N-catenin) (Alpha-catenin-related protein) | May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system (By similarity). Required for proper regulation of cortical neuronal migration and neurite growth (PubMed:30013181). It acts as a negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization (PubMed:30013181). It thereby suppresses excessive actin branching which would impair neurite growth and stability (PubMed:30013181). Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation (By similarity). {ECO:0000250|UniProtKB:Q61301, ECO:0000269|PubMed:30013181}. |
| P27105 | STOM | S231 | ochoa | Stomatin (Erythrocyte band 7 integral membrane protein) (Erythrocyte membrane protein band 7.2) (Protein 7.2b) | Regulates ion channel activity and transmembrane ion transport. Regulates ASIC2 and ASIC3 channel activity. |
| P28715 | ERCC5 | S705 | ochoa | DNA excision repair protein ERCC-5 (EC 3.1.-.-) (DNA repair protein complementing XP-G cells) (XPG) (Xeroderma pigmentosum group G-complementing protein) | Single-stranded structure-specific DNA endonuclease involved in DNA excision repair (PubMed:32522879, PubMed:32821917, PubMed:7651464, PubMed:8078765, PubMed:8090225, PubMed:8206890). Makes the 3'incision in DNA nucleotide excision repair (NER) (PubMed:32522879, PubMed:32821917, PubMed:8078765, PubMed:8090225). Binds and bends DNA repair bubble substrate and breaks base stacking at the single-strand/double-strand DNA junction of the DNA bubble (PubMed:32522879). Plays a role in base excision repair (BER) by promoting the binding of DNA glycosylase NTHL1 to its substrate and increasing NTHL1 catalytic activity that removes oxidized pyrimidines from DNA (PubMed:9927729). Involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (PubMed:16246722). Functions during the initial step of TCR in cooperation with ERCC6/CSB to recognized stalled RNA polymerase II (PubMed:16246722). Also, stimulates ERCC6/CSB binding to the DNA repair bubble and ERCC6/CSB ATPase activity (PubMed:16246722). Required for DNA replication fork maintenance and preservation of genomic stability (PubMed:26833090, PubMed:32522879). Involved in homologous recombination repair (HRR) induced by DNA replication stress by recruiting RAD51, BRCA2, and PALB2 to the damaged DNA site (PubMed:26833090). In TFIIH stimulates the 5'-3' helicase activity of XPD/ERCC2 and the DNA translocase activity of XPB/ERCC3 (PubMed:31253769). During HRR, binds to the replication fork with high specificity and stabilizes it (PubMed:32522879). Also, acts upstream of HRR, to promote the release of BRCA1 from DNA (PubMed:26833090). {ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:26833090, ECO:0000269|PubMed:31253769, ECO:0000269|PubMed:32522879, ECO:0000269|PubMed:32821917, ECO:0000269|PubMed:7651464, ECO:0000269|PubMed:8078765, ECO:0000269|PubMed:8090225, ECO:0000269|PubMed:8206890, ECO:0000269|PubMed:9927729}. |
| P29375 | KDM5A | S1598 | ochoa | Lysine-specific demethylase 5A (EC 1.14.11.67) (Histone demethylase JARID1A) (Jumonji/ARID domain-containing protein 1A) (Retinoblastoma-binding protein 2) (RBBP-2) ([histone H3]-trimethyl-L-lysine(4) demethylase 5A) | Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif (PubMed:18270511). May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation (PubMed:19430464). May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 (By similarity). Seems to act as a transcriptional corepressor for some genes such as MT1F and to favor the proliferation of cancer cells (PubMed:27427228). {ECO:0000250|UniProtKB:Q3UXZ9, ECO:0000269|PubMed:11358960, ECO:0000269|PubMed:15949438, ECO:0000269|PubMed:17320160, ECO:0000269|PubMed:17320161, ECO:0000269|PubMed:17320163, ECO:0000269|PubMed:18270511, ECO:0000269|PubMed:19430464, ECO:0000269|PubMed:27427228}. |
| P29692 | EEF1D | S37 | ochoa | Elongation factor 1-delta (EF-1-delta) (Antigen NY-CO-4) | [Isoform 1]: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1-alpha for another round of transfer of aminoacyl-tRNAs to the ribosome.; FUNCTION: [Isoform 2]: Regulates induction of heat-shock-responsive genes through association with heat shock transcription factors and direct DNA-binding at heat shock promoter elements (HSE). |
| P30305 | CDC25B | S169 | psp | M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B) | Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression (PubMed:1836978, PubMed:20360007). Directly dephosphorylates CDK1 and stimulates its kinase activity (PubMed:20360007). Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner (PubMed:17332740). The three isoforms seem to have a different level of activity (PubMed:1836978). {ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:1836978, ECO:0000269|PubMed:20360007}. |
| P35221 | CTNNA1 | S323 | ochoa | Catenin alpha-1 (Alpha E-catenin) (Cadherin-associated protein) (Renal carcinoma antigen NY-REN-13) | Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). May play a crucial role in cell differentiation. {ECO:0000250|UniProtKB:P26231, ECO:0000269|PubMed:25653389}. |
| P35227 | PCGF2 | S251 | ochoa | Polycomb group RING finger protein 2 (DNA-binding protein Mel-18) (RING finger protein 110) (Zinc finger protein 144) | Transcriptional repressor. Binds specifically to the DNA sequence 5'-GACTNGACT-3'. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells (By similarity). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:26151332). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332). {ECO:0000250|UniProtKB:P23798, ECO:0000269|PubMed:26151332}. |
| P35520 | CBS | S32 | ochoa | Cystathionine beta-synthase (EC 4.2.1.22) (Beta-thionase) (Serine sulfhydrase) | Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (PubMed:20506325, PubMed:23974653, PubMed:23981774). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity). {ECO:0000250|UniProtKB:P32232, ECO:0000269|PubMed:20506325, ECO:0000269|PubMed:23974653, ECO:0000269|PubMed:23981774}. |
| P35609 | ACTN2 | S840 | ochoa | Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. |
| P36956 | SREBF1 | S1049 | ochoa | Sterol regulatory element-binding protein 1 (SREBP-1) (Class D basic helix-loop-helix protein 1) (bHLHd1) (Sterol regulatory element-binding transcription factor 1) [Cleaved into: Processed sterol regulatory element-binding protein 1 (Transcription factor SREBF1)] | [Sterol regulatory element-binding protein 1]: Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 1), which is embedded in the endoplasmic reticulum membrane (PubMed:32322062). Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis and lipid homeostasis (By similarity). {ECO:0000250|UniProtKB:Q9WTN3, ECO:0000269|PubMed:32322062}.; FUNCTION: [Processed sterol regulatory element-binding protein 1]: Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis and lipid homeostasis (PubMed:12177166, PubMed:32322062, PubMed:8402897). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3') (PubMed:12177166, PubMed:8402897). Regulates the promoters of genes involved in cholesterol biosynthesis and the LDL receptor (LDLR) pathway of sterol regulation (PubMed:12177166, PubMed:32322062, PubMed:8402897). {ECO:0000250|UniProtKB:Q9WTN3, ECO:0000269|PubMed:12177166, ECO:0000269|PubMed:32322062, ECO:0000269|PubMed:8402897}.; FUNCTION: [Isoform SREBP-1A]: Isoform expressed only in select tissues, which has higher transcriptional activity compared to SREBP-1C (By similarity). Able to stimulate both lipogenic and cholesterogenic gene expression (PubMed:12177166, PubMed:32497488). Has a role in the nutritional regulation of fatty acids and triglycerides in lipogenic organs such as the liver (By similarity). Required for innate immune response in macrophages by regulating lipid metabolism (By similarity). {ECO:0000250|UniProtKB:Q9WTN3, ECO:0000269|PubMed:12177166, ECO:0000269|PubMed:32497488}.; FUNCTION: [Isoform SREBP-1C]: Predominant isoform expressed in most tissues, which has weaker transcriptional activity compared to isoform SREBP-1A (By similarity). Primarily controls expression of lipogenic gene (PubMed:12177166). Strongly activates global lipid synthesis in rapidly growing cells (By similarity). {ECO:0000250|UniProtKB:Q9WTN3, ECO:0000269|PubMed:12177166}.; FUNCTION: [Isoform SREBP-1aDelta]: The absence of Golgi proteolytic processing requirement makes this isoform constitutively active in transactivation of lipogenic gene promoters. {ECO:0000305|PubMed:7759101}.; FUNCTION: [Isoform SREBP-1cDelta]: The absence of Golgi proteolytic processing requirement makes this isoform constitutively active in transactivation of lipogenic gene promoters. {ECO:0000305|PubMed:7759101}. |
| P49005 | POLD2 | S254 | ochoa | DNA polymerase delta subunit 2 (DNA polymerase delta subunit p50) | Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex (PubMed:17317665, PubMed:22801543, PubMed:24449906). As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair (PubMed:12403614, PubMed:16510448, PubMed:19074196, PubMed:20334433, PubMed:24035200). Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4 (PubMed:19074196, PubMed:20334433). Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated (PubMed:24035200). Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation (PubMed:20227374). Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR) (PubMed:24310611). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites performed by Pol-delta4, independently of DNA polymerase zeta (REV3L) or eta (POLH). Facilitates abasic site bypass by DNA polymerase delta by promoting extension from the nucleotide inserted opposite the lesion. Also involved in TLS as a component of the DNA polymerase zeta complex (PubMed:24449906). Along with POLD3, dramatically increases the efficiency and processivity of DNA synthesis of the DNA polymerase zeta complex compared to the minimal zeta complex, consisting of only REV3L and REV7 (PubMed:24449906). {ECO:0000269|PubMed:12403614, ECO:0000269|PubMed:16510448, ECO:0000269|PubMed:19074196, ECO:0000269|PubMed:20227374, ECO:0000269|PubMed:20334433, ECO:0000269|PubMed:24035200, ECO:0000269|PubMed:24310611, ECO:0000269|PubMed:24449906}. |
| P49069 | CAMLG | S148 | ochoa | Guided entry of tail-anchored proteins factor CAMLG (Calcium signal-modulating cyclophilin ligand) | Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (PubMed:23041287, PubMed:24392163, PubMed:27226539). Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol (PubMed:23041287, PubMed:24392163, PubMed:27226539). Required for the stability of GET1 (PubMed:32187542). Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium (PubMed:7522304). Essential for the survival of peripheral follicular B cells (By similarity). {ECO:0000250|UniProtKB:P49070, ECO:0000269|PubMed:23041287, ECO:0000269|PubMed:24392163, ECO:0000269|PubMed:27226539, ECO:0000269|PubMed:32187542, ECO:0000269|PubMed:7522304}. |
| P51116 | FXR2 | S450 | ochoa | RNA-binding protein FXR2 (FXR2P) (FMR1 autosomal homolog 2) | mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for adult hippocampal neurogenesis (By similarity). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (By similarity). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs: mRNAs storage into membraneless compartments regulates their translation and/or stability (By similarity). Acts as a regulator of adult hippocampal neurogenesis by regulating translation and/or stability of NOG mRNA, thereby preventing NOG protein expression in the dentate gyrus (By similarity). {ECO:0000250|UniProtKB:Q61584, ECO:0000250|UniProtKB:Q9WVR4}. |
| P51582 | P2RY4 | S334 | psp | P2Y purinoceptor 4 (P2Y4) (P2P) (Uridine nucleotide receptor) (UNR) | Receptor for UTP and UDP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. Not activated by ATP or ADP. |
| P51790 | CLCN3 | S109 | psp | H(+)/Cl(-) exchange transporter 3 (Chloride channel protein 3) (ClC-3) (Chloride transporter ClC-3) | [Isoform 1]: Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons (By similarity). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (PubMed:29845874). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (PubMed:29845874). {ECO:0000250|UniProtKB:P51791, ECO:0000303|PubMed:29845874}.; FUNCTION: [Isoform 2]: Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons. {ECO:0000269|PubMed:11967229}. |
| P55010 | EIF5 | S229 | ochoa | Eukaryotic translation initiation factor 5 (eIF-5) | Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon (PubMed:11166181, PubMed:22813744, PubMed:24319994). In this complex, acts as a GTPase-activating protein, by promoting GTP hydrolysis by eIF2G (EIF2S3) (PubMed:11166181). During scanning, interacts with both EIF1 (via its C-terminal domain (CTD)) and EIF1A (via its NTD) (PubMed:22813744). This interaction with EIF1A contributes to the maintenance of EIF1 within the open 43S PIC (PubMed:24319994). When start codon is recognized, EIF5, via its NTD, induces eIF2G (EIF2S3) to hydrolyze the GTP (PubMed:11166181). Start codon recognition also induces a conformational change of the PIC to a closed state (PubMed:22813744). This change increases the affinity of EIF5-CTD for EIF2-beta (EIF2S2), which allows the release, by an indirect mechanism, of EIF1 from the PIC (PubMed:22813744). Finally, EIF5 stabilizes the PIC in its closed conformation (PubMed:22813744). {ECO:0000269|PubMed:11166181, ECO:0000269|PubMed:22813744, ECO:0000269|PubMed:24319994}. |
| P56945 | BCAR1 | S407 | ochoa | Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas) | Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion (PubMed:12432078, PubMed:12832404). Implicated in induction of cell migration and cell branching (PubMed:12432078, PubMed:12832404, PubMed:17038317). Involved in the BCAR3-mediated inhibition of TGFB signaling (By similarity). {ECO:0000250|UniProtKB:Q61140, ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:12832404, ECO:0000269|PubMed:17038317}. |
| P78317 | RNF4 | S90 | ochoa | E3 ubiquitin-protein ligase RNF4 (EC 2.3.2.27) (RING finger protein 4) (Small nuclear ring finger protein) (Protein SNURF) | E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation (PubMed:18408734, PubMed:19307308, PubMed:35013556). Regulates the degradation of several proteins including PML and the transcriptional activator PEA3 (PubMed:18408734, PubMed:19307308, PubMed:20943951). Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation (PubMed:20212317). Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1 (PubMed:19779455, PubMed:20026589). Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation (PubMed:12885770). Catalyzes ubiquitination of sumoylated PARP1 in response to PARP1 trapping to chromatin, leading to PARP1 removal from chromatin by VCP/p97 (PubMed:35013556). {ECO:0000269|PubMed:12885770, ECO:0000269|PubMed:18408734, ECO:0000269|PubMed:19307308, ECO:0000269|PubMed:19779455, ECO:0000269|PubMed:20026589, ECO:0000269|PubMed:20212317, ECO:0000269|PubMed:20943951, ECO:0000269|PubMed:35013556}. |
| P78352 | DLG4 | S511 | ochoa | Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90) | Postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for the postsynaptic clustering of crucial synaptic proteins. Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression (By similarity). Under basal conditions, cooperates with FYN to stabilize palmitoyltransferase ZDHHC5 at the synaptic membrane through FYN-mediated phosphorylation of ZDHHC5 and its subsequent inhibition of association with endocytic proteins (PubMed:26334723). {ECO:0000250|UniProtKB:Q62108, ECO:0000269|PubMed:26334723}. |
| P79483 | HLA-DRB3 | S117 | ochoa | HLA class II histocompatibility antigen, DR beta 3 chain (MHC class II antigen DRB3) | A beta chain of antigen-presenting major histocompatibility complex class II (MHCII) molecule. In complex with the alpha chain HLA-DRA, displays antigenic peptides on professional antigen presenting cells (APCs) for recognition by alpha-beta T cell receptor (TCR) on HLA-DRB3-restricted CD4-positive T cells. This guides antigen-specific T-helper effector functions, both antibody-mediated immune response and macrophage activation, to ultimately eliminate the infectious agents and transformed cells. Typically presents extracellular peptide antigens of 10 to 30 amino acids that arise from proteolysis of endocytosed antigens in lysosomes (PubMed:16148104, PubMed:19531622, PubMed:19830726, PubMed:20368442, PubMed:22929521, PubMed:23569328, PubMed:2463305, PubMed:2788702, PubMed:30282837, PubMed:31020640, PubMed:31308093, PubMed:31333679). In the tumor microenvironment, presents antigenic peptides that are primarily generated in tumor-resident APCs likely via phagocytosis of apoptotic tumor cells or macropinocytosis of secreted tumor proteins (By similarity). Presents peptides derived from intracellular proteins that are trapped in autolysosomes after macroautophagy, a mechanism especially relevant for T cell selection in the thymus and central immune tolerance (By similarity). The selection of the immunodominant epitopes follows two processing modes: 'bind first, cut/trim later' for pathogen-derived antigenic peptides and 'cut first, bind later' for autoantigens/self-peptides. The anchor residue at position 1 of the peptide N-terminus, usually a large hydrophobic residue, is essential for high affinity interaction with MHCII molecules (By similarity). {ECO:0000250|UniProtKB:P01911, ECO:0000269|PubMed:16148104, ECO:0000269|PubMed:19531622, ECO:0000269|PubMed:19830726, ECO:0000269|PubMed:20368442, ECO:0000269|PubMed:22929521, ECO:0000269|PubMed:23569328, ECO:0000269|PubMed:2463305, ECO:0000269|PubMed:2788702, ECO:0000269|PubMed:30282837, ECO:0000269|PubMed:31020640, ECO:0000269|PubMed:31308093, ECO:0000269|PubMed:31333679}.; FUNCTION: ALLELE DRB3*01:01: Exclusively presents several immunogenic epitopes derived from C.tetani neurotoxin tetX, playing a significant role in immune recognition and long-term protection (PubMed:19830726, PubMed:2463305, PubMed:2788702). Presents viral epitopes derived from HHV-6B U11, TRX2/U56 and U85 antigens to polyfunctional CD4-positive T cells with cytotoxic activity implicated in control of HHV-6B infection (PubMed:31020640). {ECO:0000269|PubMed:19830726, ECO:0000269|PubMed:2463305, ECO:0000269|PubMed:2788702, ECO:0000269|PubMed:31020640}.; FUNCTION: ALLELE DRB3*02:02 Exclusively presents several immunogenic epitopes derived from C.tetani neurotoxin tetX, playing a significant role in immune recognition and long-term protection (PubMed:19830726, PubMed:2788702). Upon EBV infection, presents to CD4-positive T cells latent antigen EBNA2 (PRSPTVFYNIPPMPLPPSQL) and lytic antigen BZLF1 (LTAYHVSTAPTGSWF) peptides, driving oligoclonal expansion and selection of virus-specific memory T cell subsets with cytotoxic potential to directly eliminate virus-infected B cells (PubMed:23569328, PubMed:31308093). Presents viral epitopes derived from HHV-6B U11, gB/U39 and gH/U48 antigens to polyfunctional CD4-positive T cells with cytotoxic activity implicated in control of HHV-6B infection (PubMed:31020640). Plays a minor role in CD4-positive T cell immune response against Dengue virus by presenting conserved peptides from capsid and non-structural NS3 proteins (PubMed:31333679). Displays peptides derived from IAV matrix protein M, implying a role in protection against IAV infection (PubMed:19830726). In the context of tumor immunesurveillance, may present to T-helper 1 cells an immunogenic epitope derived from tumor-associated antigen WT1 (KRYFKLSHLQMHSRKH), likely providing for effective antitumor immunity in a wide range of solid and hematological malignancies (PubMed:22929521). Presents to Vbeta2-positive T-helper 1 cells specifically an immunodominant peptide derived from tumor antigen CTAG1A/NY-ESO-1(PGVLLKEFTVSGNILTIRLTAADHR) and confers protective memory response (PubMed:19531622, PubMed:20368442). In metastatic epithelial tumors, presents to intratumoral CD4-positive T cells a TP53 neoantigen (HYNYMCNSSCMGSMNRRPILTIITL) carrying G245S hotspot driver mutation and may mediate tumor regression (PubMed:30282837). {ECO:0000269|PubMed:19531622, ECO:0000269|PubMed:19830726, ECO:0000269|PubMed:20368442, ECO:0000269|PubMed:22929521, ECO:0000269|PubMed:23569328, ECO:0000269|PubMed:2788702, ECO:0000269|PubMed:30282837, ECO:0000269|PubMed:31020640, ECO:0000269|PubMed:31308093, ECO:0000269|PubMed:31333679}.; FUNCTION: ALLELE DRB3*03:01: Presents a series of conserved peptides derived from the M.tuberculosis PPE family of proteins, in particular PPE29 and PPE33, known to be highly immunogenic (PubMed:32341563). Presents immunogenic epitopes derived from C.tetani neurotoxin tetX, playing a role in immune recognition and long-term protection (PubMed:2788702). Displays immunodominant viral peptides from HCV non-structural protein NS2, as part of a broad range T-helper response to resolve infection (PubMed:16148104). {ECO:0000269|PubMed:16148104, ECO:0000269|PubMed:2788702, ECO:0000269|PubMed:32341563}. |
| P84101 | SERF2 | S21 | ochoa | Small EDRK-rich factor 2 (Gastric cancer-related protein VRG107) (Protein 4F5-related) (4F5rel) (h4F5rel) | Positive regulator of amyloid protein aggregation and proteotoxicity (PubMed:20723760). Induces conformational changes in amyloid proteins, such as HTT, driving them into compact formations preceding the formation of aggregates (PubMed:20723760). {ECO:0000269|PubMed:20723760}. |
| Q01196 | RUNX1 | S295 | ochoa | Runt-related transcription factor 1 (Acute myeloid leukemia 1 protein) (Core-binding factor subunit alpha-2) (CBF-alpha-2) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEA2-alpha B) (PEBP2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit) | Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (Probable). Essential for the development of normal hematopoiesis (PubMed:17431401). Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter (PubMed:10207087, PubMed:14970218). Inhibits KAT6B-dependent transcriptional activation (By similarity). Involved in lineage commitment of immature T cell precursors. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity). Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3. Activates the expression of IL2 and IFNG and down-regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells (PubMed:17377532). Positively regulates the expression of RORC in T-helper 17 cells (By similarity). {ECO:0000250|UniProtKB:Q03347, ECO:0000269|PubMed:10207087, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:14970218, ECO:0000269|PubMed:17377532, ECO:0000269|PubMed:17431401, ECO:0000305}.; FUNCTION: Isoform AML-1G shows higher binding activities for target genes and binds TCR-beta-E2 and RAG-1 target site with threefold higher affinity than other isoforms. It is less effective in the context of neutrophil terminal differentiation. {ECO:0000250|UniProtKB:Q03347}.; FUNCTION: Isoform AML-1L interferes with the transactivation activity of RUNX1. {ECO:0000269|PubMed:9199349}. |
| Q02487 | DSC2 | S824 | ochoa | Desmocollin-2 (Cadherin family member 2) (Desmocollin-3) (Desmosomal glycoprotein II) (Desmosomal glycoprotein III) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:33596089). Promotes timely incorporation of DSG2 into desmosome intercellular junctions and promotes interaction of desmosome cell junctions with intermediate filament cytokeratin, via modulation of DSP phosphorylation (PubMed:33596089). Plays an important role in desmosome-mediated maintenance of intestinal epithelial cell intercellular adhesion strength and barrier function (PubMed:33596089). Positively regulates wound healing of intestinal mucosa via promotion of epithelial cell migration, and also plays a role in mechanotransduction of force between intestinal epithelial cells and extracellular matrix (PubMed:31967937). May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. May promote p38MAPK signaling activation that facilitates keratinocyte migration (By similarity). {ECO:0000250|UniProtKB:P55292, ECO:0000269|PubMed:31967937, ECO:0000269|PubMed:33596089}. |
| Q02487 | DSC2 | S828 | ochoa | Desmocollin-2 (Cadherin family member 2) (Desmocollin-3) (Desmosomal glycoprotein II) (Desmosomal glycoprotein III) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:33596089). Promotes timely incorporation of DSG2 into desmosome intercellular junctions and promotes interaction of desmosome cell junctions with intermediate filament cytokeratin, via modulation of DSP phosphorylation (PubMed:33596089). Plays an important role in desmosome-mediated maintenance of intestinal epithelial cell intercellular adhesion strength and barrier function (PubMed:33596089). Positively regulates wound healing of intestinal mucosa via promotion of epithelial cell migration, and also plays a role in mechanotransduction of force between intestinal epithelial cells and extracellular matrix (PubMed:31967937). May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. May promote p38MAPK signaling activation that facilitates keratinocyte migration (By similarity). {ECO:0000250|UniProtKB:P55292, ECO:0000269|PubMed:31967937, ECO:0000269|PubMed:33596089}. |
| Q03164 | KMT2A | S1115 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q04637 | EIF4G1 | S1209 | ochoa | Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:29987188). Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) (PubMed:29987188). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon (PubMed:29987188). Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning (PubMed:29987188). As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). {ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29987188}. |
| Q13017 | ARHGAP5 | S1023 | ochoa | Rho GTPase-activating protein 5 (Rho-type GTPase-activating protein 5) (p190-B) | GTPase-activating protein for Rho family members (PubMed:8537347). {ECO:0000269|PubMed:8537347}. |
| Q13523 | PRP4K | S507 | ochoa | Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog) | Serine/threonine kinase involved in spliceosomal assembly as well as mitosis and signaling regulation (PubMed:10799319, PubMed:12077342, PubMed:17513757, PubMed:17998396). Connects chromatin mediated regulation of transcription and pre-mRNA splicing (PubMed:12077342). During spliceosomal assembly, interacts with and phosphorylates PRPF6 and PRPF31, components of the U4/U6-U5 tri-small nuclear ribonucleoprotein (snRNP), to facilitate the formation of the spliceosome B complex. Plays a role in regulating transcription and the spindle assembly checkpoint (SAC) (PubMed:20118938). Associates with U5 snRNP and NCOR1 deacetylase complexes which may allow a coordination of pre-mRNA splicing with chromatin remodeling events involved in transcriptional regulation (PubMed:12077342). Associates and probably phosphorylates SMARCA4 and NCOR1 (PubMed:12077342). Phosphorylates SRSF1 (PubMed:11418604). Associates with kinetochores during mitosis and is necessary for recruitment and maintenance of the checkpoint proteins such as MAD1L1 and MAD12L1 at the kinetochores (PubMed:17998396). Phosphorylates and regulates the activity of the transcription factors such as ELK1 and KLF13 (PubMed:10799319, PubMed:17513757). Phosphorylates nuclear YAP1 and WWTR1/TAZ which induces nuclear exclusion and regulates Hippo signaling pathway, involved in tissue growth control (PubMed:29695716). {ECO:0000269|PubMed:10799319, ECO:0000269|PubMed:11418604, ECO:0000269|PubMed:12077342, ECO:0000269|PubMed:17513757, ECO:0000269|PubMed:17998396, ECO:0000269|PubMed:20118938, ECO:0000269|PubMed:29695716}. |
| Q13555 | CAMK2G | S280 | ochoa|psp | Calcium/calmodulin-dependent protein kinase type II subunit gamma (CaM kinase II subunit gamma) (CaMK-II subunit gamma) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin (PubMed:16690701). In the central nervous system, it is involved in the regulation of neurite formation and arborization (PubMed:30184290). It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q923T9, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:30184290}. |
| Q13936 | CACNA1C | S1718 | ochoa | Voltage-dependent L-type calcium channel subunit alpha-1C (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Voltage-gated calcium channel subunit alpha Cav1.2) | Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:12181424, PubMed:15454078, PubMed:15863612, PubMed:16299511, PubMed:17224476, PubMed:20953164, PubMed:23677916, PubMed:24728418, PubMed:26253506, PubMed:27218670, PubMed:29078335, PubMed:29742403, PubMed:30023270, PubMed:30172029, PubMed:34163037, PubMed:8099908). Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm (By similarity). Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm (PubMed:15454078, PubMed:15863612, PubMed:17224476, PubMed:24728418, PubMed:26253506). Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells (PubMed:28119464). Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable). {ECO:0000250|UniProtKB:P15381, ECO:0000269|PubMed:12181424, ECO:0000269|PubMed:15454078, ECO:0000269|PubMed:15863612, ECO:0000269|PubMed:16299511, ECO:0000269|PubMed:17224476, ECO:0000269|PubMed:20953164, ECO:0000269|PubMed:23677916, ECO:0000269|PubMed:24728418, ECO:0000269|PubMed:25260352, ECO:0000269|PubMed:25633834, ECO:0000269|PubMed:26253506, ECO:0000269|PubMed:27218670, ECO:0000269|PubMed:28119464, ECO:0000269|PubMed:29078335, ECO:0000269|PubMed:29742403, ECO:0000269|PubMed:30023270, ECO:0000269|PubMed:30172029, ECO:0000269|PubMed:31430211, ECO:0000269|PubMed:34163037, ECO:0000269|PubMed:8099908, ECO:0000305}.; FUNCTION: [Isoform 12]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:12176756, ECO:0000269|PubMed:7737988}.; FUNCTION: [Isoform 13]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:17071743}.; FUNCTION: [Isoform 14]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:17071743}.; FUNCTION: [Isoform 15]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:17071743}.; FUNCTION: [Isoform 16]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:9087614}.; FUNCTION: [Isoform 17]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:9087614}.; FUNCTION: [Isoform 18]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:8392192}.; FUNCTION: [Isoform 19]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:7737988}.; FUNCTION: [Isoform 20]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:7737988}.; FUNCTION: [Isoform 21]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:9607315}.; FUNCTION: [Isoform 22]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:9607315}.; FUNCTION: [Isoform 23]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:9607315}.; FUNCTION: [Isoform 24]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:17071743}.; FUNCTION: [Isoform 25]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:17071743}.; FUNCTION: [Isoform 26]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:9013606}.; FUNCTION: [Isoform 27]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:9013606}.; FUNCTION: [Isoform 34]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. {ECO:0000269|PubMed:11741969}.; FUNCTION: (Microbial infection) Acts as a receptor for Influenzavirus (PubMed:29779930). May play a critical role in allowing virus entry when sialylated and expressed on lung tissues (PubMed:29779930). {ECO:0000269|PubMed:29779930}. |
| Q14137 | BOP1 | S598 | ochoa | Ribosome biogenesis protein BOP1 (Block of proliferation 1 protein) | Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. {ECO:0000255|HAMAP-Rule:MF_03027, ECO:0000269|PubMed:17353269, ECO:0000269|PubMed:24120868}. |
| Q14574 | DSC3 | S819 | ochoa | Desmocollin-3 (Cadherin family member 3) (Desmocollin-4) (HT-CP) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (By similarity). Required for cell-cell adhesion in the epidermis, as a result required for the maintenance of the dermal cohesion and the dermal barrier function (PubMed:19717567). Required for cell-cell adhesion of epithelial cell layers surrounding the telogen hair club, as a result plays an important role in telogen hair shaft anchorage (By similarity). Essential for successful completion of embryo compaction and embryo development (By similarity). {ECO:0000250|UniProtKB:P55850, ECO:0000269|PubMed:19717567}. |
| Q14574 | DSC3 | S823 | ochoa | Desmocollin-3 (Cadherin family member 3) (Desmocollin-4) (HT-CP) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (By similarity). Required for cell-cell adhesion in the epidermis, as a result required for the maintenance of the dermal cohesion and the dermal barrier function (PubMed:19717567). Required for cell-cell adhesion of epithelial cell layers surrounding the telogen hair club, as a result plays an important role in telogen hair shaft anchorage (By similarity). Essential for successful completion of embryo compaction and embryo development (By similarity). {ECO:0000250|UniProtKB:P55850, ECO:0000269|PubMed:19717567}. |
| Q14687 | GSE1 | S899 | ochoa | Genetic suppressor element 1 | None |
| Q14966 | ZNF638 | S1913 | ochoa | Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein) | Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:30487602, PubMed:8647861). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q61464, ECO:0000269|PubMed:30487602, ECO:0000269|PubMed:8647861}. |
| Q15058 | KIF14 | S911 | ochoa | Kinesin-like protein KIF14 | Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis (PubMed:16648480, PubMed:24784001). During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively (PubMed:16431929). Regulates cell growth through regulation of cell cycle progression and cytokinesis (PubMed:24854087). During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic process which controls CDKN1B degradation, resulting in positive regulation of cyclins, including CCNE1, CCND1 and CCNB1 (PubMed:24854087). During late neurogenesis, regulates the cerebellar, cerebral cortex and olfactory bulb development through regulation of apoptosis, cell proliferation and cell division (By similarity). Also is required for chromosome congression and alignment during mitotic cell cycle process (PubMed:15843429). Regulates cell spreading, focal adhesion dynamics, and cell migration through its interaction with RADIL resulting in regulation of RAP1A-mediated inside-out integrin activation by tethering RADIL on microtubules (PubMed:23209302). {ECO:0000250|UniProtKB:L0N7N1, ECO:0000269|PubMed:15843429, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:16648480, ECO:0000269|PubMed:23209302, ECO:0000269|PubMed:24784001, ECO:0000269|PubMed:24854087}. |
| Q15149 | PLEC | S4354 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q15366 | PCBP2 | S90 | ochoa | Poly(rC)-binding protein 2 (Alpha-CP2) (Heterogeneous nuclear ribonucleoprotein E2) (hnRNP E2) | Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:12414943, PubMed:7607214). Major cellular poly(rC)-binding protein (PubMed:12414943). Also binds poly(rU) (PubMed:12414943). Acts as a negative regulator of antiviral signaling (PubMed:19881509, PubMed:35322803). Negatively regulates cellular antiviral responses mediated by MAVS signaling (PubMed:19881509). It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation (PubMed:19881509). Negativeley regulates the cGAS-STING pathway via interaction with CGAS, preventing the formation of liquid-like droplets in which CGAS is activated (PubMed:35322803). Together with PCBP1, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). {ECO:0000250|UniProtKB:Q61990, ECO:0000269|PubMed:12414943, ECO:0000269|PubMed:19881509, ECO:0000269|PubMed:35322803, ECO:0000269|PubMed:7607214}.; FUNCTION: (Microbial infection) In case of infection by poliovirus, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12414943, PubMed:24371074). Also plays a role in initiation of viral RNA replication in concert with the viral protein 3CD (PubMed:12414943). {ECO:0000269|PubMed:12414943, ECO:0000269|PubMed:24371074}. |
| Q15743 | GPR68 | S331 | ochoa | G-protein coupled receptor 68 (G-protein coupled receptor 12A) (GPR12A) (Ovarian cancer G-protein coupled receptor 1) (OGR-1) | Proton-sensing G-protein coupled receptor activated by extracellular pH, which is required to monitor pH changes and generate adaptive reactions (PubMed:12955148, PubMed:29677517, PubMed:32865988, PubMed:33478938, PubMed:39753132). The receptor is almost silent at pH 7.8 but fully activated at pH 6.8 (PubMed:12955148, PubMed:39753132). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as phospholipase C (PubMed:29677517, PubMed:39753132). GPR68 is mainly coupled to G(q) G proteins and mediates production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (PubMed:29677517, PubMed:39753132). Acts as a key mechanosensor of fluid shear stress and membrane stretch (PubMed:29677517, PubMed:30471999). Expressed in endothelial cells of small-diameter resistance arteries, where it mediates flow-induced dilation in response to shear stress (PubMed:29677517). May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone (By similarity). Acts as a regulator of calcium-sensing receptor CASR in a seesaw manner: GPR68-mediated signaling inhibits CASR signaling in response to protons, while CASR inhibits GPR68 in presence of extracellular calcium (By similarity). {ECO:0000250|UniProtKB:Q8BFQ3, ECO:0000269|PubMed:12955148, ECO:0000269|PubMed:29677517, ECO:0000269|PubMed:30471999, ECO:0000269|PubMed:32865988, ECO:0000269|PubMed:33478938, ECO:0000269|PubMed:39753132}. |
| Q2LD37 | BLTP1 | S4607 | ochoa | Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein) | Tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (Probable). Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as a regulator of phagocytosis (PubMed:31540829). {ECO:0000269|PubMed:30906834, ECO:0000269|PubMed:31540829, ECO:0000305|PubMed:35015055, ECO:0000305|PubMed:35491307}. |
| Q2M3G4 | SHROOM1 | S248 | ochoa | Protein Shroom1 (Apical protein 2) | May be involved in the assembly of microtubule arrays during cell elongation. {ECO:0000250}. |
| Q2NKQ1 | SGSM1 | S685 | ochoa | Small G protein signaling modulator 1 (RUN and TBC1 domain-containing protein 2) | Interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. Promotes GTP hydrolysis by RAB34 and RAB36. Probably functions as a GTPase effector with RAB9A and RAB9B; does not stimulate GTP hydrolysis with RAB9A and RAB9B. {ECO:0000269|PubMed:22637480}. |
| Q30154 | HLA-DRB5 | S117 | ochoa | HLA class II histocompatibility antigen, DR beta 5 chain (DR beta-5) (DR2-beta-2) (Dw2) (MHC class II antigen DRB5) | Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading. |
| Q4VC05 | BCL7A | S186 | ochoa | B-cell CLL/lymphoma 7 protein family member A | None |
| Q52LW3 | ARHGAP29 | S98 | ochoa | Rho GTPase-activating protein 29 (PTPL1-associated RhoGAP protein 1) (Rho-type GTPase-activating protein 29) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis. {ECO:0000269|PubMed:15752761, ECO:0000269|PubMed:9305890}. |
| Q53GS9 | USP39 | S46 | ochoa | Ubiquitin carboxyl-terminal hydrolase 39 (EC 3.4.19.12) (SAD1 homolog) (U4/U6.U5 tri-snRNP-associated 65 kDa protein) | Deubiquitinating enzyme that plays a role in many cellular processes including cellular antiviral response, epithelial morphogenesis, DNA repair or B-cell development (PubMed:33127822, PubMed:34614178). Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the precatalytic spliceosome (PubMed:11350945, PubMed:26912367). Specifically regulates immunoglobulin gene rearrangement in a spliceosome-dependent manner, which involves modulating chromatin interactions at the Igh locus and therefore plays an essential role in B-cell development (By similarity). Regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint (PubMed:18728397). Regulates apoptosis and G2/M cell cycle checkpoint in response to DNA damage by deubiquitinating and stabilizing CHK2 (PubMed:30771428). Also plays an important role in DNA repair by controlling the recruitment of XRCC4/LIG4 to DNA double-strand breaks for non-homologous end-joining repair (PubMed:34614178). Participates in antiviral activity by affecting the type I IFN signaling by stabilizing STAT1 and decreasing its 'Lys-6'-linked ubiquitination (PubMed:33127822). Contributes to non-canonical Wnt signaling during epidermal differentiation (By similarity). Acts as a negative regulator NF-kappa-B activation through deubiquitination of 'Lys-48'-linked ubiquitination of NFKBIA (PubMed:36651806). {ECO:0000250|UniProtKB:Q3TIX9, ECO:0000269|PubMed:11350945, ECO:0000269|PubMed:18728397, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:30771428, ECO:0000269|PubMed:33127822, ECO:0000269|PubMed:34614178, ECO:0000269|PubMed:36651806}. |
| Q5C9Z4 | NOM1 | S114 | ochoa | Nucleolar MIF4G domain-containing protein 1 (SGD1 homolog) | Plays a role in targeting PPP1CA to the nucleolus. {ECO:0000269|PubMed:17965019}. |
| Q5FWE3 | PRRT3 | S865 | ochoa | Proline-rich transmembrane protein 3 | None |
| Q5M775 | SPECC1 | S37 | ochoa | Cytospin-B (Nuclear structure protein 5) (NSP5) (Sperm antigen HCMOGT-1) (Sperm antigen with calponin homology and coiled-coil domains 1) | None |
| Q5TKA1 | LIN9 | S76 | ochoa | Protein lin-9 homolog (HuLin-9) (hLin-9) (Beta subunit-associated regulator of apoptosis) (TUDOR gene similar protein) (Type I interferon receptor beta chain-associated protein) (pRB-associated protein) | Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition. {ECO:0000269|PubMed:15538385, ECO:0000269|PubMed:16730350}. |
| Q5VT06 | CEP350 | S506 | ochoa | Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) | Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CPAP (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}. |
| Q5XUX0 | FBXO31 | S33 | ochoa|psp | F-box only protein 31 | Substrate-recognition component of the SCF(FBXO31) protein ligase complex, which specifically mediates the ubiquitination of proteins amidated at their C-terminus in response to oxidative stress, leading to their degradation by the proteasome (PubMed:39880951). FBXO31 specifically recognizes and binds C-terminal peptides bearing an amide: C-terminal amidation in response to oxidative stress takes place following protein fragmentation (PubMed:39880951). The SCF(FBXO31) also plays a role in G1 arrest following DNA damage by mediating ubiquitination of phosphorylated cyclin-D1 (CCND1), promoting its degradation by the proteasome, resulting in G1 arrest (PubMed:19412162, PubMed:29279382). The SCF(FBXO31) complex is however not a major regulator of CCND1 stability during the G1/S transition (By similarity). In response to genotoxic stress, the SCF(FBXO31) complex directs ubiquitination and degradation of phosphorylated MDM2, thereby promoting p53/TP53-mediated DNA damage response (PubMed:26124108). SCF(FBXO31) complex is required for genomic integrity by catalyzing ubiquitination and degradation of cyclin-A (CCNA1 and/or CCNA2) during the G1 phase (PubMed:31413110). In response to genotoxic stress, the SCF(FBXO31) complex directs ubiquitination and degradation of phosphorylated FBXO46 and MAP2K6 (PubMed:24936062, PubMed:30171069). SCF(FBXO31) complex promotes ubiquitination and degradation of CDT1 during the G2 phase to prevent re-replication (PubMed:24828503). The SCF(FBXO31) complex also mediates ubiquitination and degradation of DUSP6, OGT and PARD6A (PubMed:23469015, PubMed:34686346, PubMed:39894887). {ECO:0000250|UniProtKB:Q3TQF0, ECO:0000269|PubMed:19412162, ECO:0000269|PubMed:23469015, ECO:0000269|PubMed:24828503, ECO:0000269|PubMed:24936062, ECO:0000269|PubMed:26124108, ECO:0000269|PubMed:29279382, ECO:0000269|PubMed:30171069, ECO:0000269|PubMed:31413110, ECO:0000269|PubMed:34686346, ECO:0000269|PubMed:39880951, ECO:0000269|PubMed:39894887}. |
| Q6DN90 | IQSEC1 | S211 | ochoa | IQ motif and SEC7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein) (BRAG2) | Guanine nucleotide exchange factor for ARF1 and ARF6 (PubMed:11226253, PubMed:24058294). Guanine nucleotide exchange factor activity is enhanced by lipid binding (PubMed:24058294). Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalization of beta-1 integrin (PubMed:16461286). Involved in neuronal development (Probable). In neurons, plays a role in the control of vesicle formation by endocytoc cargo. Upon long term depression, interacts with GRIA2 and mediates the activation of ARF6 to internalize synaptic AMPAR receptors (By similarity). {ECO:0000250|UniProtKB:A0A0G2JUG7, ECO:0000269|PubMed:11226253, ECO:0000269|PubMed:16461286, ECO:0000269|PubMed:24058294, ECO:0000305|PubMed:31607425}. |
| Q6NV74 | CRACDL | S609 | ochoa | CRACD-like protein | None |
| Q6P1M3 | LLGL2 | S961 | ochoa | LLGL scribble cell polarity complex component 2 (HGL) (Lethal(2) giant larvae protein homolog 2) | Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity. {ECO:0000269|PubMed:15632202}. |
| Q6PCB6 | ABHD17C | S211 | ochoa | Alpha/beta hydrolase domain-containing protein 17C (Abhydrolase domain-containing protein 17C) (EC 3.1.2.22) | Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards NRAS and DLG4/PSD95. {ECO:0000269|PubMed:26701913}. |
| Q6RW13 | AGTRAP | S127 | ochoa | Type-1 angiotensin II receptor-associated protein (AT1 receptor-associated protein) | Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalization as well as mechanism of receptor desensitization such as phosphorylation. Also induces a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity. {ECO:0000269|PubMed:12960423}. |
| Q6WKZ4 | RAB11FIP1 | S477 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
| Q6ZNJ1 | NBEAL2 | S770 | ochoa | Neurobeachin-like protein 2 | Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis. {ECO:0000269|PubMed:21765411, ECO:0000269|PubMed:21765412}. |
| Q6ZNL6 | FGD5 | S812 | ochoa | FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23) | Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape. {ECO:0000269|PubMed:22328776}. |
| Q6ZRS2 | SRCAP | S2955 | ochoa | Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) | Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}. |
| Q6ZSZ5 | ARHGEF18 | S98 | ochoa | Rho guanine nucleotide exchange factor 18 (114 kDa Rho-specific guanine nucleotide exchange factor) (p114-Rho-GEF) (p114RhoGEF) (Septin-associated RhoGEF) (SA-RhoGEF) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also acts as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells (PubMed:22006950). {ECO:0000269|PubMed:11085924, ECO:0000269|PubMed:14512443, ECO:0000269|PubMed:15558029, ECO:0000269|PubMed:22006950, ECO:0000269|PubMed:28132693}. |
| Q7L4E1 | MIGA2 | S228 | ochoa | Mitoguardin 2 (Protein FAM73B) | Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD. {ECO:0000269|PubMed:26711011}. |
| Q7L5N1 | COPS6 | S211 | ochoa | COP9 signalosome complex subunit 6 (SGN6) (Signalosome subunit 6) (JAB1-containing signalosome subunit 6) (MOV34 homolog) (Vpr-interacting protein) (hVIP) | Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity. Stabilizes COP1 through reducing COP1 auto-ubiquitination and decelerating COP1 turnover rate, hence regulates the ubiquitination of COP1 targets. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:21625211, ECO:0000269|PubMed:9535219}. |
| Q7Z2Y5 | NRK | S1031 | ochoa | Nik-related protein kinase (EC 2.7.11.1) | May phosphorylate cofilin-1 and induce actin polymerization through this process, during the late stages of embryogenesis. Involved in the TNF-alpha-induced signaling pathway (By similarity). {ECO:0000250}. |
| Q86SQ0 | PHLDB2 | S524 | ochoa | Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) | Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}. |
| Q86U28 | ISCA2 | S29 | ochoa | Iron-sulfur cluster assembly 2 homolog, mitochondrial (HESB-like domain-containing protein 1) | Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. May be involved in the binding of an intermediate of Fe/S cluster assembly. {ECO:0000269|PubMed:22323289}. |
| Q86YC2 | PALB2 | S172 | ochoa | Partner and localizer of BRCA2 | Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks (PubMed:16793542, PubMed:19369211, PubMed:19423707, PubMed:22941656, PubMed:24141787, PubMed:28319063). Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA) (PubMed:20871615). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51 (PubMed:20871616). Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination (PubMed:19369211). Via its WD repeats is proposed to scaffold a HR complex containing RAD51C and BRCA2 which is thought to play a role in HR-mediated DNA repair (PubMed:24141787). Essential partner of BRCA2 that promotes the localization and stability of BRCA2 (PubMed:16793542). Also enables its recombinational repair and checkpoint functions of BRCA2 (PubMed:16793542). May act by promoting stable association of BRCA2 with nuclear structures, allowing BRCA2 to escape the effects of proteasome-mediated degradation (PubMed:16793542). Binds DNA with high affinity for D loop, which comprises single-stranded, double-stranded and branched DNA structures (PubMed:20871616). May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with BRCA2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity (PubMed:24485656). {ECO:0000269|PubMed:16793542, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:19423707, ECO:0000269|PubMed:20871615, ECO:0000269|PubMed:20871616, ECO:0000269|PubMed:22941656, ECO:0000269|PubMed:24141787, ECO:0000269|PubMed:24485656, ECO:0000269|PubMed:28319063}. |
| Q8IUW3 | SPATA2L | S290 | ochoa | Spermatogenesis-associated protein 2-like protein (SPATA2-like protein) | None |
| Q8IVF2 | AHNAK2 | S38 | ochoa | Protein AHNAK2 | None |
| Q8IVM0 | CCDC50 | S143 | ochoa | Coiled-coil domain-containing protein 50 (Protein Ymer) | Involved in EGFR signaling. {ECO:0000269|PubMed:15314609}. |
| Q8IWR0 | ZC3H7A | S429 | ochoa | Zinc finger CCCH domain-containing protein 7A | May be a specific regulator of miRNA biogenesis. Binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the 3'-ATA(A/T)-5' motif in the apical loop. {ECO:0000269|PubMed:28431233}. |
| Q8IZQ1 | WDFY3 | S3326 | ochoa | WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy) | Required for selective macroautophagy (aggrephagy). Acts as an adapter protein by linking specific proteins destined for degradation to the core autophagic machinery members, such as the ATG5-ATG12-ATG16L E3-like ligase, SQSTM1 and LC3 (PubMed:20417604). Along with p62/SQSTM1, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with SQSTM1, required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Important for normal brain development. Essential for the formation of axonal tracts throughout the brain and spinal cord, including the formation of the major forebrain commissures. Involved in the ability of neural cells to respond to guidance cues. Required for cortical neurons to respond to the trophic effects of netrin-1/NTN1 (By similarity). Regulates Wnt signaling through the removal of DVL3 aggregates, likely in an autophagy-dependent manner. This process may be important for the determination of brain size during embryonic development (PubMed:27008544). May regulate osteoclastogenesis by acting on the TNFSF11/RANKL - TRAF6 pathway (By similarity). After cytokinetic abscission, involved in midbody remnant degradation (PubMed:24128730). In vitro strongly binds to phosphatidylinositol 3-phosphate (PtdIns3P) (PubMed:15292400). {ECO:0000250|UniProtKB:Q6VNB8, ECO:0000269|PubMed:15292400, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20417604, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:27008544}. |
| Q8N122 | RPTOR | S606 | psp | Regulatory-associated protein of mTOR (Raptor) (p150 target of rapamycin (TOR)-scaffold protein) | Component of the mechanistic target of rapamycin complex 1 (mTORC1), an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:26588989, PubMed:32561715, PubMed:37541260). In response to nutrients, growth factors or amino acids, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating several substrates, such as ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:26588989, PubMed:37541260). In the same time, it inhibits catabolic pathways by phosphorylating the autophagy initiation components ULK1 and ATG13, as well as transcription factor TFEB, a master regulators of lysosomal biogenesis and autophagy (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:32561715, PubMed:37541260). The mTORC1 complex is inhibited in response to starvation and amino acid depletion (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:37541260). Within the mTORC1 complex, RPTOR acts both as a molecular adapter, which (1) mediates recruitment of mTORC1 to lysosomal membranes via interaction with small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD), and a (2) substrate-specific adapter, which promotes substrate specificity by binding to TOS motif-containing proteins and direct them towards the active site of the MTOR kinase domain for phosphorylation (PubMed:12747827, PubMed:24403073, PubMed:26588989, PubMed:37541260). mTORC1 complex regulates many cellular processes, such as odontoblast and osteoclast differentiation or neuronal transmission (By similarity). mTORC1 complex in excitatory neuronal transmission is required for the prosocial behavior induced by the psychoactive substance lysergic acid diethylamide (LSD) (By similarity). {ECO:0000250|UniProtKB:Q8K4Q0, ECO:0000269|PubMed:12150925, ECO:0000269|PubMed:12150926, ECO:0000269|PubMed:12747827, ECO:0000269|PubMed:24403073, ECO:0000269|PubMed:26588989, ECO:0000269|PubMed:32561715, ECO:0000269|PubMed:37541260}. |
| Q8N567 | ZCCHC9 | S28 | ochoa | Zinc finger CCHC domain-containing protein 9 | May down-regulate transcription mediated by NF-kappa-B and the serum response element. {ECO:0000269|PubMed:18721783}. |
| Q8N6U8 | GPR161 | S360 | ochoa | G-protein coupled receptor 161 (G-protein coupled receptor RE2) | Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity). {ECO:0000250}. |
| Q8NCE2 | MTMR14 | S576 | ochoa | Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14 (EC 3.1.3.95) (HCV NS5A-transactivated protein 4 splice variant A-binding protein 1) (NS5ATP4ABP1) (Myotubularin-related protein 14) (Phosphatidylinositol-3-phosphate phosphatase) (hJumpy) | Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate. {ECO:0000269|PubMed:17008356}. |
| Q8NEY1 | NAV1 | S194 | ochoa | Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) | May be involved in neuronal migration. {ECO:0000250}. |
| Q8NHH9 | ATL2 | S35 | ochoa | Atlastin-2 (ATL-2) (EC 3.6.5.-) (ADP-ribosylation factor-like protein 6-interacting protein 2) | Atlastin-2 (ATL2) is a membrane-anchored GTPase that mediates the GTP-dependent fusion of endoplasmic reticulum (ER) membranes, maintaining the continuous ER network. It facilitates the formation of three-way junctions where ER tubules intersect (PubMed:18270207, PubMed:19665976, PubMed:22065636, PubMed:27619977, PubMed:34817557). Two atlastin-2 on neighboring ER tubules bind GTP and form loose homodimers through the GB1/RHD3-type G domains and 3HB regions. Upon GTP hydrolysis, the 3HB regions tighten, pulling the membranes together to drive their fusion. After fusion, the homodimer disassembles upon release of inorganic phosphate (Pi). Subsequently, GDP dissociates, resetting the monomers to a conformation ready for a new fusion cycle (By similarity). {ECO:0000250|UniProtKB:Q8WXF7, ECO:0000269|PubMed:18270207, ECO:0000269|PubMed:19665976, ECO:0000269|PubMed:22065636, ECO:0000269|PubMed:27619977, ECO:0000269|PubMed:34817557}. |
| Q8TD43 | TRPM4 | S1152 | psp | Transient receptor potential cation channel subfamily M member 4 (hTRPM4) (Calcium-activated non-selective cation channel 1) (Long transient receptor potential channel 4) (LTrpC-4) (LTrpC4) (Melastatin-4) | Calcium-activated selective cation channel that mediates membrane depolarization (PubMed:12015988, PubMed:12842017, PubMed:29211723, PubMed:30528822). While it is activated by increase in intracellular Ca(2+), it is impermeable to it (PubMed:12015988). Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane (PubMed:12015988). It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway. Plays a role in keratinocyte differentiation (PubMed:30528822). {ECO:0000269|PubMed:11535825, ECO:0000269|PubMed:12015988, ECO:0000269|PubMed:12799367, ECO:0000269|PubMed:12842017, ECO:0000269|PubMed:14758478, ECO:0000269|PubMed:15121803, ECO:0000269|PubMed:15331675, ECO:0000269|PubMed:15472118, ECO:0000269|PubMed:15550671, ECO:0000269|PubMed:15590641, ECO:0000269|PubMed:15845551, ECO:0000269|PubMed:16186107, ECO:0000269|PubMed:16407466, ECO:0000269|PubMed:16424899, ECO:0000269|PubMed:16806463, ECO:0000269|PubMed:20625999, ECO:0000269|PubMed:20656926, ECO:0000269|PubMed:29211723, ECO:0000269|PubMed:30528822}.; FUNCTION: [Isoform 2]: Lacks channel activity. {ECO:0000269|PubMed:12842017}. |
| Q8TD55 | PLEKHO2 | S164 | ochoa | Pleckstrin homology domain-containing family O member 2 (PH domain-containing family O member 2) (Pleckstrin homology domain-containing family Q member 1) (PH domain-containing family Q member 1) | None |
| Q8TDD1 | DDX54 | S71 | ochoa | ATP-dependent RNA helicase DDX54 (EC 3.6.4.13) (ATP-dependent RNA helicase DP97) (DEAD box RNA helicase 97 kDa) (DEAD box protein 54) | Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors. {ECO:0000269|PubMed:12466272}. |
| Q8TEB9 | RHBDD1 | Y264 | psp | Rhomboid-related protein 4 (RRP4) (EC 3.4.21.105) (Rhomboid domain-containing protein 1) (Rhomboid-like protein 4) | Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions. Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded membrane proteins. Required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Functions in BIK, MPZ, PKD1, PTCRA, RHO, STEAP3 and TRAC processing. Involved in the regulation of exosomal secretion; inhibits the TSAP6-mediated secretion pathway. Involved in the regulation of apoptosis; modulates BIK-mediated apoptotic activity. Also plays a role in the regulation of spermatogenesis; inhibits apoptotic activity in spermatogonia. {ECO:0000269|PubMed:18953687, ECO:0000269|PubMed:22624035}. |
| Q8TEX9 | IPO4 | S972 | ochoa | Importin-4 (Imp4) (Importin-4b) (Imp4b) (Ran-binding protein 4) (RanBP4) | Nuclear transport receptor that mediates nuclear import of proteins, such as histones, RPS3A, TNP2 and VDR (PubMed:11823430, PubMed:16207705, PubMed:17682055, PubMed:21454524). Serves as receptor for nuclear localization signals (NLS) in cargo substrates (PubMed:11823430, PubMed:16207705). Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:11823430, PubMed:16207705). At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran (PubMed:11823430). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:11823430). Mediates the nuclear import of the histone H3-H4 dimer when in complex with ASF1 (ASF1A or ASF1B) (PubMed:21454524, PubMed:29408485). Mediates the ligand-independent nuclear import of vitamin D receptor (VDR) (PubMed:16207705). In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS (PubMed:12610148). {ECO:0000269|PubMed:11823430, ECO:0000269|PubMed:12610148, ECO:0000269|PubMed:16207705, ECO:0000269|PubMed:17682055, ECO:0000269|PubMed:21454524, ECO:0000269|PubMed:29408485}. |
| Q96B33 | CLDN23 | S206 | ochoa | Claudin-23 | Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. {ECO:0000250}. |
| Q96HP0 | DOCK6 | S159 | ochoa | Dedicator of cytokinesis protein 6 | Acts as a guanine nucleotide exchange factor (GEF) for CDC42 and RAC1 small GTPases. Through its activation of CDC42 and RAC1, may regulate neurite outgrowth (By similarity). {ECO:0000250, ECO:0000269|PubMed:17196961}. |
| Q96PE1 | ADGRA2 | S963 | ochoa | Adhesion G protein-coupled receptor A2 (G-protein coupled receptor 124) (Tumor endothelial marker 5) | Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:28289266, PubMed:30026314). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (PubMed:30026314). ADGRA2-tethering function does not rely on its G-protein coupled receptor (GPCR) structure but instead on its combined capacity to interact with RECK extracellularly and recruit the Dishevelled scaffolding protein intracellularly (PubMed:30026314). Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate (PubMed:16982628). {ECO:0000250|UniProtKB:Q91ZV8, ECO:0000269|PubMed:16982628, ECO:0000269|PubMed:28289266, ECO:0000269|PubMed:30026314}. |
| Q96QT4 | TRPM7 | S1500 | ochoa | Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form] | Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644). {ECO:0000250|UniProtKB:Q923J1, ECO:0000269|PubMed:11385574, ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:18365021, ECO:0000269|PubMed:18394644, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:35561741, ECO:0000269|PubMed:36027648}.; FUNCTION: [TRPM7 channel, cleaved form]: The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling. {ECO:0000250|UniProtKB:Q923J1}.; FUNCTION: [TRPM7 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development. {ECO:0000250|UniProtKB:Q923J1}. |
| Q96RG2 | PASK | S956 | ochoa|psp | PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (hPASK) (EC 2.7.11.1) | Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation. {ECO:0000269|PubMed:16275910, ECO:0000269|PubMed:17052199, ECO:0000269|PubMed:17595531, ECO:0000269|PubMed:20943661, ECO:0000269|PubMed:21181396, ECO:0000269|PubMed:21418524}. |
| Q96SN8 | CDK5RAP2 | S366 | ochoa | CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215) | Potential regulator of CDK5 activity via its interaction with CDK5R1 (PubMed:15164053). Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter (PubMed:19282672). Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends (PubMed:18042621, PubMed:17959831, PubMed:19553473). Regulates centrosomal maturation by recruitment of the gamma-tubulin ring complex (gTuRC) onto centrosomes (PubMed:18042621, PubMed:17959831, PubMed:26485573, PubMed:39321809). In complex with PDE4DIP isoform 13/MMG8/SMYLE, MAPRE1 and AKAP9, contributes to microtubules nucleation and extension from the centrosome to the cell periphery (PubMed:29162697). Required for the recruitment of AKAP9 to centrosomes (PubMed:29162697). Plays a role in neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q8K389, ECO:0000269|PubMed:15164053, ECO:0000269|PubMed:17959831, ECO:0000269|PubMed:18042621, ECO:0000269|PubMed:19282672, ECO:0000269|PubMed:19553473, ECO:0000269|PubMed:26485573, ECO:0000269|PubMed:29162697, ECO:0000269|PubMed:39321809}. |
| Q99832 | CCT7 | S59 | psp | T-complex protein 1 subunit eta (TCP-1-eta) (EC 3.6.1.-) (CCT-eta) (Chaperonin containing T-complex polypeptide 1 subunit 7) (HIV-1 Nef-interacting protein) [Cleaved into: T-complex protein 1 subunit eta, N-terminally processed] | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). {ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| Q99952 | PTPN18 | S390 | ochoa | Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Brain-derived phosphatase) | Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues. |
| Q9BRJ6 | C7orf50 | S97 | ochoa | Protein cholesin | Hormone secreted from the intestine in response to cholesterol, where it acts to inhibit cholesterol synthesis in the liver and VLDL secretion,leading to a reduction in circulating cholesterol levels. Acts through binding to its receptor, GPR146. {ECO:0000269|PubMed:38503280}. |
| Q9BV36 | MLPH | S204 | ochoa | Melanophilin (Exophilin-3) (Slp homolog lacking C2 domains a) (SlaC2-a) (Synaptotagmin-like protein 2a) | Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A. {ECO:0000269|PubMed:12062444}. |
| Q9BZ71 | PITPNM3 | S907 | ochoa | Membrane-associated phosphatidylinositol transfer protein 3 (Phosphatidylinositol transfer protein, membrane-associated 3) (PITPnm 3) (Pyk2 N-terminal domain-interacting receptor 1) (NIR-1) | Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro) (By similarity). Binds calcium ions. {ECO:0000250}. |
| Q9C0C2 | TNKS1BP1 | S214 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9C0J8 | WDR33 | S1210 | ochoa | pre-mRNA 3' end processing protein WDR33 (WD repeat-containing protein 33) (WD repeat-containing protein of 146 kDa) | Essential for both cleavage and polyadenylation of pre-mRNA 3' ends. {ECO:0000269|PubMed:19217410}. |
| Q9H1J1 | UPF3A | S401 | ochoa | Regulator of nonsense transcripts 3A (Nonsense mRNA reducing factor 3A) (Up-frameshift suppressor 3 homolog A) (hUpf3) | Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. However, UPF3A is shown to be only marginally active in NMD as compared to UPF3B. Binds spliced mRNA upstream of exon-exon junctions. In vitro, weakly stimulates translation. {ECO:0000269|PubMed:11163187, ECO:0000269|PubMed:16601204}. |
| Q9H4Z2 | ZNF335 | S686 | ochoa | Zinc finger protein 335 (NRC-interacting factor 1) (NIF-1) | Component or associated component of some histone methyltransferase complexes may regulate transcription through recruitment of those complexes on gene promoters (PubMed:19131338, PubMed:23178126). Enhances ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:12215545, PubMed:18180299, PubMed:19131338). Plays an important role in neural progenitor cell proliferation and self-renewal through the regulation of specific genes involved brain development, including REST (PubMed:23178126). Also controls the expression of genes involved in somatic development and regulates, for instance, lymphoblast proliferation (PubMed:23178126). {ECO:0000269|PubMed:12215545, ECO:0000269|PubMed:18180299, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:23178126}. |
| Q9H814 | PHAX | S146 | ochoa | Phosphorylated adapter RNA export protein (RNA U small nuclear RNA export adapter protein) | A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus (PubMed:39011894). Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner (By similarity). Also plays a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Also binds to telomerase RNA. {ECO:0000250, ECO:0000269|PubMed:15574332, ECO:0000269|PubMed:15574333}. |
| Q9H9A5 | CNOT10 | S21 | ochoa | CCR4-NOT transcription complex subunit 10 | Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex. {ECO:0000269|PubMed:23221646}. |
| Q9HCM7 | FBRSL1 | S31 | ochoa | Fibrosin-1-like protein (AUTS2-like protein) (HBV X-transactivated gene 9 protein) (HBV XAg-transactivated protein 9) | None |
| Q9NPG3 | UBN1 | S135 | ochoa | Ubinuclein-1 (HIRA-binding protein) (Protein VT4) (Ubiquitously expressed nuclear protein) | Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:19029251}. |
| Q9NQT8 | KIF13B | S1791 | ochoa | Kinesin-like protein KIF13B (Kinesin-like protein GAKIN) | Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes. {ECO:0000269|PubMed:20194617}. |
| Q9NQT8 | KIF13B | S1795 | ochoa | Kinesin-like protein KIF13B (Kinesin-like protein GAKIN) | Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes. {ECO:0000269|PubMed:20194617}. |
| Q9NZM3 | ITSN2 | S957 | ochoa | Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein) | Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:23999003}. |
| Q9P0J7 | KCMF1 | S207 | ochoa | E3 ubiquitin-protein ligase KCMF1 (EC 2.3.2.27) (FGF-induced in gastric cancer) (Potassium channel modulatory factor) (PCMF) (ZZ-type zinc finger-containing protein 1) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and then transfers it to targeted substrates, promoting their degradation by the proteasome (PubMed:15581609, PubMed:25582440, PubMed:34893540, PubMed:37891180, PubMed:38297121). Together with UBR4, component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR4, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). {ECO:0000269|PubMed:15581609, ECO:0000269|PubMed:25582440, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:37891180, ECO:0000269|PubMed:38297121}. |
| Q9P227 | ARHGAP23 | S545 | ochoa | Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| Q9P227 | ARHGAP23 | S1188 | ochoa | Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| Q9P253 | VPS18 | S689 | ochoa | Vacuolar protein sorting-associated protein 18 homolog (hVPS18) | Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203). Involved in dendrite development of Pukinje cells (By similarity). {ECO:0000250|UniProtKB:Q8R307, ECO:0000269|PubMed:25783203, ECO:0000305|PubMed:11382755, ECO:0000305|PubMed:23351085, ECO:0000305|PubMed:25783203}. |
| Q9UBC3 | DNMT3B | S31 | ochoa | DNA (cytosine-5)-methyltransferase 3B (Dnmt3b) (EC 2.1.1.37) (DNA methyltransferase HsaIIIB) (DNA MTase HsaIIIB) (M.HsaIIIB) | Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Functions as a transcriptional corepressor by associating with ZHX1. Required for DUX4 silencing in somatic cells (PubMed:27153398). {ECO:0000250, ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:17303076, ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18567530, ECO:0000269|PubMed:27153398}. |
| Q9UBQ7 | GRHPR | S36 | ochoa | Glyoxylate reductase/hydroxypyruvate reductase (EC 1.1.1.79) (EC 1.1.1.81) | Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate, oxidizes D-glycerate to hydroxypyruvate. {ECO:0000269|PubMed:10484776, ECO:0000269|PubMed:10524214}. |
| Q9UGI8 | TES | S140 | ochoa | Testin (TESS) | Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. Inhibits tumor cell growth. {ECO:0000269|PubMed:11420696, ECO:0000269|PubMed:12571287, ECO:0000269|PubMed:12695497}. |
| Q9UHB6 | LIMA1 | S114 | ochoa | LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) | Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}. |
| Q9UHI6 | DDX20 | S320 | ochoa | Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.15) (EC 3.6.4.13) (Component of gems 3) (DEAD box protein 20) (DEAD box protein DP 103) (Gemin-3) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs). {ECO:0000269|PubMed:18984161}. |
| Q9UIF9 | BAZ2A | S1207 | ochoa | Bromodomain adjacent to zinc finger domain protein 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3) | Regulatory subunit of the ATP-dependent NoRC-1 and NoRC-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Directly stimulates the ATPase activity of SMARCA5 in the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). The NoRC-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NoRC-5 ISWI chromatin remodeling complex, mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription (By similarity). Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac (By similarity). Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity). {ECO:0000250|UniProtKB:Q91YE5, ECO:0000269|PubMed:28801535}. |
| Q9UIG0 | BAZ1B | S508 | ochoa | Tyrosine-protein kinase BAZ1B (EC 2.7.10.2) (Bromodomain adjacent to zinc finger domain protein 1B) (Williams syndrome transcription factor) (Williams-Beuren syndrome chromosomal region 10 protein) (Williams-Beuren syndrome chromosomal region 9 protein) (hWALp2) | Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator (PubMed:19092802). Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph) (PubMed:19092802, PubMed:19234442). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19092802, PubMed:19234442). Regulatory subunit of the ATP-dependent WICH-1 and WICH-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:11980720, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The WICH-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the WICH-5 ISWI chromatin remodeling complex (PubMed:28801535). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the recruitment of the WICH-5 ISWI chromatin remodeling complex to replication foci during DNA replication (PubMed:15543136). {ECO:0000250|UniProtKB:Q9Z277, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:19092802, ECO:0000269|PubMed:19234442, ECO:0000269|PubMed:28801535}. |
| Q9UKI8 | TLK1 | S357 | ochoa | Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (PKU-beta) (Tousled-like kinase 1) | Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:10588641, ECO:0000269|PubMed:11314006, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:9427565}. |
| Q9UMN6 | KMT2B | S2146 | ochoa | Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17707229, PubMed:25561738). Likely plays a redundant role with KMT2C in enriching H3K4me1 marks on primed and active enhancer elements (PubMed:24081332). Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 (PubMed:17707229). Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development (By similarity). Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation (By similarity). {ECO:0000250|UniProtKB:O08550, ECO:0000269|PubMed:17707229, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q9UPN4 | CEP131 | S45 | ochoa | Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) (Pre-acrosome localization protein 1) | Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Also acts as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). Essential for maintaining proper centriolar satellite integrity (PubMed:30804208). {ECO:0000250|UniProtKB:Q62036, ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:22797915, ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:24185901, ECO:0000269|PubMed:24550735, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:30804208}. |
| Q9UPN4 | CEP131 | S498 | ochoa | Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) (Pre-acrosome localization protein 1) | Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Also acts as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). Essential for maintaining proper centriolar satellite integrity (PubMed:30804208). {ECO:0000250|UniProtKB:Q62036, ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:22797915, ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:24185901, ECO:0000269|PubMed:24550735, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:30804208}. |
| Q9UQC2 | GAB2 | S210 | ochoa|psp | GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100) | Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. {ECO:0000269|PubMed:15750601, ECO:0000269|PubMed:19172738}. |
| Q9Y490 | TLN1 | S455 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| Q9Y4F5 | CEP170B | S512 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
| Q9Y4F5 | CEP170B | S1196 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
| R4GMW8 | BIVM-ERCC5 | S1159 | ochoa | DNA excision repair protein ERCC-5 | None |
| O95218 | ZRANB2 | T50 | Sugiyama | Zinc finger Ran-binding domain-containing protein 2 (Zinc finger protein 265) (Zinc finger, splicing) | Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). May interfere with constitutive 5'-splice site selection. {ECO:0000269|PubMed:11448987, ECO:0000269|PubMed:21256132}. |
| P50416 | CPT1A | S612 | Sugiyama | Carnitine O-palmitoyltransferase 1, liver isoform (CPT1-L) (EC 2.3.1.21) (Carnitine O-palmitoyltransferase I, liver isoform) (CPT I) (CPTI-L) (Carnitine palmitoyltransferase 1A) (Succinyltransferase CPT1A) (EC 2.3.1.-) | Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion (PubMed:11350182, PubMed:14517221, PubMed:16651524, PubMed:9691089). Also possesses a lysine succinyltransferase activity that can regulate enzymatic activity of substrate proteins such as ENO1 and metabolism independent of its classical carnitine O-palmitoyltransferase activity (PubMed:29425493). Plays an important role in hepatic triglyceride metabolism (By similarity). Also plays a role in inducible regulatory T-cell (iTreg) differentiation once activated by butyryl-CoA that antagonizes malonyl-CoA-mediated CPT1A repression (By similarity). Sustains the IFN-I response by recruiting ZDHCC4 to palmitoylate MAVS at the mitochondria leading to MAVS stabilization and activation (PubMed:38016475). Promotes ROS-induced oxidative stress in liver injury via modulation of NFE2L2 and NLRP3-mediated signaling pathways (By similarity). {ECO:0000250|UniProtKB:P32198, ECO:0000269|PubMed:11350182, ECO:0000269|PubMed:14517221, ECO:0000269|PubMed:16651524, ECO:0000269|PubMed:29425493, ECO:0000269|PubMed:38016475, ECO:0000269|PubMed:9691089}. |
| O43283 | MAP3K13 | S411 | Sugiyama | Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Leucine zipper-bearing kinase) (Mixed lineage kinase) (MLK) | Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B. {ECO:0000269|PubMed:11726277, ECO:0000269|PubMed:12492477, ECO:0000269|PubMed:9353328}. |
| P40222 | TXLNA | S65 | Sugiyama | Alpha-taxilin | May be involved in intracellular vesicle traffic and potentially in calcium-dependent exocytosis in neuroendocrine cells. |
| P11277 | SPTB | S439 | Sugiyama | Spectrin beta chain, erythrocytic (Beta-I spectrin) | Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. |
| Q9BWF3 | RBM4 | S343 | Sugiyama | RNA-binding protein 4 (Lark homolog) (hLark) (RNA-binding motif protein 4) (RNA-binding motif protein 4a) | RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA. Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation. Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress. Associates to internal ribosome entry segment (IRES) in target mRNA species under stress conditions. Plays a role for miRNA-guided RNA cleavage and translation suppression by promoting association of AGO2-containing miRNPs with their cognate target mRNAs. Associates with miRNAs during muscle cell differentiation. Binds preferentially to 5'-CGCGCG[GCA]-3' motif in vitro. {ECO:0000269|PubMed:12628928, ECO:0000269|PubMed:16260624, ECO:0000269|PubMed:16777844, ECO:0000269|PubMed:16934801, ECO:0000269|PubMed:17284590, ECO:0000269|PubMed:17932509, ECO:0000269|PubMed:19801630, ECO:0000269|PubMed:21343338, ECO:0000269|PubMed:21518792, ECO:0000269|PubMed:37548402}. |
| Q86W92 | PPFIBP1 | S630 | Sugiyama | Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1) (hSGT2) | May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A. {ECO:0000269|PubMed:9624153}. |
| P39019 | RPS19 | S98 | Sugiyama | Small ribosomal subunit protein eS19 (40S ribosomal protein S19) | Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Required for pre-rRNA processing and maturation of 40S ribosomal subunits (PubMed:16990592). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:16990592, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| Q9Y285 | FARSA | S352 | Sugiyama | Phenylalanine--tRNA ligase alpha subunit (EC 6.1.1.20) (CML33) (Phenylalanyl-tRNA synthetase alpha subunit) (PheRS) | None |
| Q15569 | TESK1 | S49 | Sugiyama | Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1) | Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues (By similarity). Regulates the cellular cytoskeleton by enhancing actin stress fiber formation via phosphorylation of cofilin and by preventing microtubule breakdown via inhibition of TAOK1/MARKK kinase activity (By similarity). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Positively regulates integrin-mediated cell spreading, via phosphorylation of cofilin (PubMed:15584898). Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of ciliary vesicle directional trafficking to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (PubMed:25849865). Probably plays a central role at and after the meiotic phase of spermatogenesis (By similarity). {ECO:0000250|UniProtKB:O70146, ECO:0000250|UniProtKB:Q63572, ECO:0000269|PubMed:15584898, ECO:0000269|PubMed:25849865}. |
| Q9H4A4 | RNPEP | S29 | Sugiyama | Aminopeptidase B (AP-B) (EC 3.4.11.6) (Arginine aminopeptidase) (Arginyl aminopeptidase) | Exopeptidase which selectively removes arginine and/or lysine residues from the N-terminus of several peptide substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin and Arg(-1)-Lys(0)-somatostatin-14. Can hydrolyze leukotriene A4 (LTA-4) into leukotriene B4 (LTB-4) (By similarity). {ECO:0000250}. |
| P12270 | TPR | S1241 | Sugiyama | Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:11952838, PubMed:22253824). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:21613532, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:9864356}. |
| Q9Y383 | LUC7L2 | S50 | Sugiyama | Putative RNA-binding protein Luc7-like 2 | May bind to RNA via its Arg/Ser-rich domain. |
| P51153 | RAB13 | S155 | Sugiyama | Ras-related protein Rab-13 (EC 3.6.5.2) (Cell growth-inhibiting gene 4 protein) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB13 is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through regulation of endothelial cells chemotaxis. Also involved in neurite outgrowth. Has also been proposed to play a role in post-Golgi membrane trafficking from the TGN to the recycling endosome. Finally, it has been involved in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore may play a role in glucose homeostasis. {ECO:0000269|PubMed:12058051, ECO:0000269|PubMed:15096524, ECO:0000269|PubMed:15528189, ECO:0000269|PubMed:16525024, ECO:0000269|PubMed:18779367, ECO:0000269|PubMed:20008558, ECO:0000269|PubMed:35343654}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9909396 | Circadian clock | 0.000010 | 5.016 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.000038 | 4.416 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 0.000225 | 3.648 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 0.000297 | 3.528 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 0.000297 | 3.528 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.000276 | 3.559 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.000429 | 3.367 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.000429 | 3.367 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.000429 | 3.367 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.000217 | 3.664 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.000429 | 3.367 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.000768 | 3.115 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.000838 | 3.077 |
| R-HSA-8951911 | RUNX3 regulates RUNX1-mediated transcription | 0.001008 | 2.997 |
| R-HSA-5673000 | RAF activation | 0.001349 | 2.870 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.001743 | 2.759 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.001900 | 2.721 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.002566 | 2.591 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.002384 | 2.623 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.002757 | 2.560 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.003169 | 2.499 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.003841 | 2.416 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.003841 | 2.416 |
| R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 0.003913 | 2.407 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.003841 | 2.416 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.003705 | 2.431 |
| R-HSA-429947 | Deadenylation of mRNA | 0.005139 | 2.289 |
| R-HSA-9620244 | Long-term potentiation | 0.005623 | 2.250 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.010480 | 1.980 |
| R-HSA-8953854 | Metabolism of RNA | 0.009655 | 2.015 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.010114 | 1.995 |
| R-HSA-983712 | Ion channel transport | 0.010502 | 1.979 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 0.011362 | 1.945 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.013057 | 1.884 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 0.016524 | 1.782 |
| R-HSA-877300 | Interferon gamma signaling | 0.016779 | 1.775 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.019142 | 1.718 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.019142 | 1.718 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.021283 | 1.672 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.022476 | 1.648 |
| R-HSA-376172 | DSCAM interactions | 0.044682 | 1.350 |
| R-HSA-8939247 | RUNX1 regulates transcription of genes involved in interleukin signaling | 0.076886 | 1.114 |
| R-HSA-8939245 | RUNX1 regulates transcription of genes involved in BCR signaling | 0.076886 | 1.114 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.087379 | 1.059 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 0.087379 | 1.059 |
| R-HSA-8939256 | RUNX1 regulates transcription of genes involved in WNT signaling | 0.097753 | 1.010 |
| R-HSA-9645135 | STAT5 Activation | 0.097753 | 1.010 |
| R-HSA-9732724 | IFNG signaling activates MAPKs | 0.108010 | 0.967 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.026668 | 1.574 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 0.118150 | 0.928 |
| R-HSA-446107 | Type I hemidesmosome assembly | 0.118150 | 0.928 |
| R-HSA-451308 | Activation of Ca-permeable Kainate Receptor | 0.138089 | 0.860 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 0.138089 | 0.860 |
| R-HSA-4839744 | Signaling by APC mutants | 0.147890 | 0.830 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.147890 | 0.830 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.147890 | 0.830 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.147890 | 0.830 |
| R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse | 0.046756 | 1.330 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.157580 | 0.802 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.167160 | 0.777 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.167160 | 0.777 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.167160 | 0.777 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.167160 | 0.777 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.167160 | 0.777 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.167160 | 0.777 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 0.058325 | 1.234 |
| R-HSA-8877330 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | 0.176632 | 0.753 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.176632 | 0.753 |
| R-HSA-69166 | Removal of the Flap Intermediate | 0.185997 | 0.730 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 0.195256 | 0.709 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.195256 | 0.709 |
| R-HSA-390522 | Striated Muscle Contraction | 0.077277 | 1.112 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.204410 | 0.689 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.080603 | 1.094 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.213460 | 0.671 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 0.213460 | 0.671 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.037734 | 1.423 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 0.222408 | 0.653 |
| R-HSA-191859 | snRNP Assembly | 0.042250 | 1.374 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.042250 | 1.374 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.097858 | 1.009 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 0.231255 | 0.636 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.101425 | 0.994 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.048673 | 1.313 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.048673 | 1.313 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.240002 | 0.620 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.053786 | 1.269 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.248650 | 0.604 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.248650 | 0.604 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.248650 | 0.604 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.248650 | 0.604 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.248650 | 0.604 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.248650 | 0.604 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.057332 | 1.242 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.066667 | 1.176 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.127325 | 0.895 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.265652 | 0.576 |
| R-HSA-380287 | Centrosome maturation | 0.070584 | 1.151 |
| R-HSA-211999 | CYP2E1 reactions | 0.290442 | 0.537 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 0.290442 | 0.537 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.154567 | 0.811 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.054943 | 1.260 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.054943 | 1.260 |
| R-HSA-72649 | Translation initiation complex formation | 0.158547 | 0.800 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.298519 | 0.525 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.100726 | 0.997 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.314399 | 0.503 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.036683 | 1.436 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.195116 | 0.710 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.337551 | 0.472 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.345095 | 0.462 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.345095 | 0.462 |
| R-HSA-72172 | mRNA Splicing | 0.044908 | 1.348 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.359926 | 0.444 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.359926 | 0.444 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.359926 | 0.444 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.159016 | 0.799 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.367216 | 0.435 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.367216 | 0.435 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.381549 | 0.418 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.262064 | 0.582 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.320888 | 0.494 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.052425 | 1.280 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.152586 | 0.816 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.274708 | 0.561 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.105395 | 0.977 |
| R-HSA-8931987 | RUNX1 regulates estrogen receptor mediated transcription | 0.108010 | 0.967 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 0.195256 | 0.709 |
| R-HSA-354192 | Integrin signaling | 0.073997 | 1.131 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.174648 | 0.758 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 0.345095 | 0.462 |
| R-HSA-8939242 | RUNX1 regulates transcription of genes involved in differentiation of keratinocy... | 0.118150 | 0.928 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 0.167160 | 0.777 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.087383 | 1.059 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.123534 | 0.908 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.089436 | 1.048 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 0.374423 | 0.427 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.186983 | 0.728 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 0.055347 | 1.257 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.174648 | 0.758 |
| R-HSA-5576893 | Phase 2 - plateau phase | 0.213460 | 0.671 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.186983 | 0.728 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.325058 | 0.488 |
| R-HSA-69186 | Lagging Strand Synthesis | 0.257199 | 0.590 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.367216 | 0.435 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.224225 | 0.649 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.359926 | 0.444 |
| R-HSA-525793 | Myogenesis | 0.052425 | 1.280 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.352553 | 0.453 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.108665 | 0.964 |
| R-HSA-1538133 | G0 and Early G1 | 0.352553 | 0.453 |
| R-HSA-8941333 | RUNX2 regulates genes involved in differentiation of myeloid cells | 0.066273 | 1.179 |
| R-HSA-1614603 | Cysteine formation from homocysteine | 0.108010 | 0.967 |
| R-HSA-451306 | Ionotropic activity of kainate receptors | 0.147890 | 0.830 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.157580 | 0.802 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.157580 | 0.802 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.176632 | 0.753 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 0.282273 | 0.549 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 0.282273 | 0.549 |
| R-HSA-9865881 | Complex III assembly | 0.290442 | 0.537 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.290442 | 0.537 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.290442 | 0.537 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.170597 | 0.768 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.314399 | 0.503 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.345095 | 0.462 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.150607 | 0.822 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.070584 | 1.151 |
| R-HSA-69190 | DNA strand elongation | 0.352553 | 0.453 |
| R-HSA-170968 | Frs2-mediated activation | 0.176632 | 0.753 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.211699 | 0.674 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.374423 | 0.427 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.083972 | 1.076 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.150896 | 0.821 |
| R-HSA-9027307 | Biosynthesis of maresin-like SPMs | 0.213460 | 0.671 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.228413 | 0.641 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.228413 | 0.641 |
| R-HSA-169893 | Prolonged ERK activation events | 0.204410 | 0.689 |
| R-HSA-9762292 | Regulation of CDH11 function | 0.138089 | 0.860 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.042250 | 1.374 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.231255 | 0.636 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.089436 | 1.048 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.367216 | 0.435 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.091649 | 1.038 |
| R-HSA-165159 | MTOR signalling | 0.112336 | 0.949 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.041332 | 1.384 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 0.231255 | 0.636 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 0.290442 | 0.537 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.231255 | 0.636 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.190997 | 0.719 |
| R-HSA-187706 | Signalling to p38 via RIT and RIN | 0.087379 | 1.059 |
| R-HSA-170984 | ARMS-mediated activation | 0.128177 | 0.892 |
| R-HSA-1483226 | Synthesis of PI | 0.147890 | 0.830 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.089436 | 1.048 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.158547 | 0.800 |
| R-HSA-420029 | Tight junction interactions | 0.298519 | 0.525 |
| R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 0.322205 | 0.492 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 0.352553 | 0.453 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 0.374423 | 0.427 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.381549 | 0.418 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.381549 | 0.418 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.210206 | 0.677 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.306504 | 0.514 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 0.138089 | 0.860 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.298519 | 0.525 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.298519 | 0.525 |
| R-HSA-69275 | G2/M Transition | 0.031356 | 1.504 |
| R-HSA-8951664 | Neddylation | 0.297378 | 0.527 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.032637 | 1.486 |
| R-HSA-3295583 | TRP channels | 0.052425 | 1.280 |
| R-HSA-9702518 | STAT5 activation downstream of FLT3 ITD mutants | 0.213460 | 0.671 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 0.248650 | 0.604 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.314399 | 0.503 |
| R-HSA-5334118 | DNA methylation | 0.329922 | 0.482 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.337551 | 0.472 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.374423 | 0.427 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.140289 | 0.853 |
| R-HSA-187687 | Signalling to ERKs | 0.381549 | 0.418 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.290442 | 0.537 |
| R-HSA-202403 | TCR signaling | 0.164502 | 0.784 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.175640 | 0.755 |
| R-HSA-447038 | NrCAM interactions | 0.076886 | 1.114 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 0.167160 | 0.777 |
| R-HSA-69109 | Leading Strand Synthesis | 0.167160 | 0.777 |
| R-HSA-69091 | Polymerase switching | 0.167160 | 0.777 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.067577 | 1.170 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.146668 | 0.834 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.135084 | 0.869 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.374423 | 0.427 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.266279 | 0.575 |
| R-HSA-69242 | S Phase | 0.123770 | 0.907 |
| R-HSA-9018682 | Biosynthesis of maresins | 0.282273 | 0.549 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.098424 | 1.007 |
| R-HSA-397014 | Muscle contraction | 0.128450 | 0.891 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 0.128177 | 0.892 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.306504 | 0.514 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.329922 | 0.482 |
| R-HSA-5693538 | Homology Directed Repair | 0.192725 | 0.715 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.123534 | 0.908 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.374423 | 0.427 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.100188 | 0.999 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 0.087379 | 1.059 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 0.087379 | 1.059 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 0.118150 | 0.928 |
| R-HSA-9754560 | SARS-CoV-2 modulates autophagy | 0.147890 | 0.830 |
| R-HSA-5682910 | LGI-ADAM interactions | 0.147890 | 0.830 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.185997 | 0.730 |
| R-HSA-419408 | Lysosphingolipid and LPA receptors | 0.195256 | 0.709 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.195256 | 0.709 |
| R-HSA-9766229 | Degradation of CDH1 | 0.138858 | 0.857 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.359926 | 0.444 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.367216 | 0.435 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 0.367216 | 0.435 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 0.374423 | 0.427 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.374423 | 0.427 |
| R-HSA-169911 | Regulation of Apoptosis | 0.381549 | 0.418 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.378540 | 0.422 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 0.195256 | 0.709 |
| R-HSA-202433 | Generation of second messenger molecules | 0.101425 | 0.994 |
| R-HSA-449836 | Other interleukin signaling | 0.240002 | 0.620 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.356937 | 0.447 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.185997 | 0.730 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 0.204410 | 0.689 |
| R-HSA-1362409 | Mitochondrial iron-sulfur cluster biogenesis | 0.248650 | 0.604 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 0.298519 | 0.525 |
| R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | 0.306504 | 0.514 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.064747 | 1.189 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.345095 | 0.462 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.359926 | 0.444 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.131665 | 0.881 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.261354 | 0.583 |
| R-HSA-8849468 | PTK6 Regulates Proteins Involved in RNA Processing | 0.076886 | 1.114 |
| R-HSA-9635465 | Suppression of apoptosis | 0.147890 | 0.830 |
| R-HSA-392517 | Rap1 signalling | 0.240002 | 0.620 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.322205 | 0.492 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.329922 | 0.482 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.329922 | 0.482 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.337551 | 0.472 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.359926 | 0.444 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.374423 | 0.427 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.045069 | 1.346 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.105028 | 0.979 |
| R-HSA-446728 | Cell junction organization | 0.255718 | 0.592 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.359926 | 0.444 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.204410 | 0.689 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 0.204410 | 0.689 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.070584 | 1.151 |
| R-HSA-1500931 | Cell-Cell communication | 0.188438 | 0.725 |
| R-HSA-73894 | DNA Repair | 0.269019 | 0.570 |
| R-HSA-8983432 | Interleukin-15 signaling | 0.167160 | 0.777 |
| R-HSA-3214842 | HDMs demethylate histones | 0.298519 | 0.525 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.232607 | 0.633 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.242200 | 0.616 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.133671 | 0.874 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.073997 | 1.131 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 0.222408 | 0.653 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.190997 | 0.719 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.036257 | 1.441 |
| R-HSA-4839726 | Chromatin organization | 0.369412 | 0.432 |
| R-HSA-3371556 | Cellular response to heat stress | 0.201420 | 0.696 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.128177 | 0.892 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.038715 | 1.412 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.195256 | 0.709 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 0.222408 | 0.653 |
| R-HSA-200425 | Carnitine shuttle | 0.282273 | 0.549 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.150607 | 0.822 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.224225 | 0.649 |
| R-HSA-2408508 | Metabolism of ingested SeMet, Sec, MeSec into H2Se | 0.381549 | 0.418 |
| R-HSA-1989781 | PPARA activates gene expression | 0.137720 | 0.861 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 0.329922 | 0.482 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.141819 | 0.848 |
| R-HSA-202424 | Downstream TCR signaling | 0.105395 | 0.977 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.153588 | 0.814 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.228413 | 0.641 |
| R-HSA-417957 | P2Y receptors | 0.185997 | 0.730 |
| R-HSA-373753 | Nephrin family interactions | 0.248650 | 0.604 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.315288 | 0.501 |
| R-HSA-422475 | Axon guidance | 0.115977 | 0.936 |
| R-HSA-162582 | Signal Transduction | 0.242266 | 0.616 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.041332 | 1.384 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.064441 | 1.191 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.359926 | 0.444 |
| R-HSA-9675108 | Nervous system development | 0.154557 | 0.811 |
| R-HSA-418038 | Nucleotide-like (purinergic) receptors | 0.231255 | 0.636 |
| R-HSA-1266738 | Developmental Biology | 0.091152 | 1.040 |
| R-HSA-913531 | Interferon Signaling | 0.043729 | 1.359 |
| R-HSA-9942503 | Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) | 0.204410 | 0.689 |
| R-HSA-9945266 | Differentiation of T cells | 0.204410 | 0.689 |
| R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 0.298519 | 0.525 |
| R-HSA-186763 | Downstream signal transduction | 0.345095 | 0.462 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.127692 | 0.894 |
| R-HSA-5358508 | Mismatch Repair | 0.231255 | 0.636 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.108665 | 0.964 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.195116 | 0.710 |
| R-HSA-8848021 | Signaling by PTK6 | 0.195116 | 0.710 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.304151 | 0.517 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.070763 | 1.150 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.345802 | 0.461 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.249592 | 0.603 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.277081 | 0.557 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.290442 | 0.537 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.290442 | 0.537 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.371515 | 0.430 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.314399 | 0.503 |
| R-HSA-75153 | Apoptotic execution phase | 0.127325 | 0.895 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.253636 | 0.596 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.313892 | 0.503 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.170597 | 0.768 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.358151 | 0.446 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.307678 | 0.512 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.295754 | 0.529 |
| R-HSA-109581 | Apoptosis | 0.338766 | 0.470 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.320888 | 0.494 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.382118 | 0.418 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.382118 | 0.418 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.382586 | 0.417 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.382586 | 0.417 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.387451 | 0.412 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 0.388594 | 0.411 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.388594 | 0.411 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 0.388594 | 0.411 |
| R-HSA-111933 | Calmodulin induced events | 0.388594 | 0.411 |
| R-HSA-8853659 | RET signaling | 0.388594 | 0.411 |
| R-HSA-111997 | CaM pathway | 0.388594 | 0.411 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.388594 | 0.411 |
| R-HSA-69239 | Synthesis of DNA | 0.394657 | 0.404 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.394657 | 0.404 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.394657 | 0.404 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.395559 | 0.403 |
| R-HSA-4641258 | Degradation of DVL | 0.395559 | 0.403 |
| R-HSA-4641257 | Degradation of AXIN | 0.395559 | 0.403 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.395559 | 0.403 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.395559 | 0.403 |
| R-HSA-419037 | NCAM1 interactions | 0.395559 | 0.403 |
| R-HSA-549127 | SLC-mediated transport of organic cations | 0.395559 | 0.403 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.395559 | 0.403 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.398657 | 0.399 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.402445 | 0.395 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.402445 | 0.395 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 0.409254 | 0.388 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.409254 | 0.388 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.409254 | 0.388 |
| R-HSA-9648002 | RAS processing | 0.409254 | 0.388 |
| R-HSA-69541 | Stabilization of p53 | 0.409254 | 0.388 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.409254 | 0.388 |
| R-HSA-72766 | Translation | 0.409265 | 0.388 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.415985 | 0.381 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.415985 | 0.381 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.415985 | 0.381 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.415985 | 0.381 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.415985 | 0.381 |
| R-HSA-9854311 | Maturation of TCA enzymes and regulation of TCA cycle | 0.415985 | 0.381 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.415985 | 0.381 |
| R-HSA-8982491 | Glycogen metabolism | 0.415985 | 0.381 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.422639 | 0.374 |
| R-HSA-9607240 | FLT3 Signaling | 0.422639 | 0.374 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.422639 | 0.374 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.422639 | 0.374 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.422639 | 0.374 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.422639 | 0.374 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 0.422639 | 0.374 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.422639 | 0.374 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.422639 | 0.374 |
| R-HSA-5617833 | Cilium Assembly | 0.427848 | 0.369 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.429219 | 0.367 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.429219 | 0.367 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.429219 | 0.367 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.429219 | 0.367 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.429219 | 0.367 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.433465 | 0.363 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.434082 | 0.362 |
| R-HSA-111996 | Ca-dependent events | 0.435724 | 0.361 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.435724 | 0.361 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.435724 | 0.361 |
| R-HSA-68877 | Mitotic Prometaphase | 0.436862 | 0.360 |
| R-HSA-373760 | L1CAM interactions | 0.437950 | 0.359 |
| R-HSA-9710421 | Defective pyroptosis | 0.442155 | 0.354 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.442155 | 0.354 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.442155 | 0.354 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.442155 | 0.354 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 0.442155 | 0.354 |
| R-HSA-9907900 | Proteasome assembly | 0.448513 | 0.348 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.448513 | 0.348 |
| R-HSA-373752 | Netrin-1 signaling | 0.448513 | 0.348 |
| R-HSA-5683826 | Surfactant metabolism | 0.448513 | 0.348 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.449468 | 0.347 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.454799 | 0.342 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.454799 | 0.342 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.454799 | 0.342 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.454799 | 0.342 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.454799 | 0.342 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.454799 | 0.342 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.454799 | 0.342 |
| R-HSA-9824272 | Somitogenesis | 0.454799 | 0.342 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.454799 | 0.342 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.461014 | 0.336 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.461014 | 0.336 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.461014 | 0.336 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.461014 | 0.336 |
| R-HSA-9675135 | Diseases of DNA repair | 0.461014 | 0.336 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.464618 | 0.333 |
| R-HSA-6798695 | Neutrophil degranulation | 0.465723 | 0.332 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.467158 | 0.331 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.468367 | 0.329 |
| R-HSA-5357801 | Programmed Cell Death | 0.475268 | 0.323 |
| R-HSA-194138 | Signaling by VEGF | 0.475819 | 0.323 |
| R-HSA-69206 | G1/S Transition | 0.475819 | 0.323 |
| R-HSA-6805567 | Keratinization | 0.478174 | 0.320 |
| R-HSA-73893 | DNA Damage Bypass | 0.479238 | 0.319 |
| R-HSA-389661 | Glyoxylate metabolism and glycine degradation | 0.479238 | 0.319 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.479238 | 0.319 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.479238 | 0.319 |
| R-HSA-114608 | Platelet degranulation | 0.483207 | 0.316 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.485176 | 0.314 |
| R-HSA-109704 | PI3K Cascade | 0.485176 | 0.314 |
| R-HSA-68886 | M Phase | 0.489112 | 0.311 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.491046 | 0.309 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.491046 | 0.309 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.491046 | 0.309 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.495452 | 0.305 |
| R-HSA-72187 | mRNA 3'-end processing | 0.496850 | 0.304 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.496850 | 0.304 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.496850 | 0.304 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.496850 | 0.304 |
| R-HSA-5576891 | Cardiac conduction | 0.501396 | 0.300 |
| R-HSA-9843745 | Adipogenesis | 0.501396 | 0.300 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.502588 | 0.299 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.502588 | 0.299 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 0.502588 | 0.299 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.502588 | 0.299 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.502588 | 0.299 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.508261 | 0.294 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.508556 | 0.294 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.513869 | 0.289 |
| R-HSA-9753281 | Paracetamol ADME | 0.513869 | 0.289 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.519414 | 0.284 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.519414 | 0.284 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.519414 | 0.284 |
| R-HSA-5578775 | Ion homeostasis | 0.519414 | 0.284 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.519414 | 0.284 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.524896 | 0.280 |
| R-HSA-112399 | IRS-mediated signalling | 0.524896 | 0.280 |
| R-HSA-1483166 | Synthesis of PA | 0.524896 | 0.280 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.529633 | 0.276 |
| R-HSA-6807070 | PTEN Regulation | 0.533086 | 0.273 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.533086 | 0.273 |
| R-HSA-180786 | Extension of Telomeres | 0.535674 | 0.271 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.535674 | 0.271 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.535674 | 0.271 |
| R-HSA-1632852 | Macroautophagy | 0.539940 | 0.268 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.540972 | 0.267 |
| R-HSA-8873719 | RAB geranylgeranylation | 0.540972 | 0.267 |
| R-HSA-983189 | Kinesins | 0.540972 | 0.267 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.540972 | 0.267 |
| R-HSA-351202 | Metabolism of polyamines | 0.540972 | 0.267 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.540972 | 0.267 |
| R-HSA-379724 | tRNA Aminoacylation | 0.540972 | 0.267 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.546209 | 0.263 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.546209 | 0.263 |
| R-HSA-112043 | PLC beta mediated events | 0.546209 | 0.263 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.546209 | 0.263 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.546209 | 0.263 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.546209 | 0.263 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.550091 | 0.260 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.551387 | 0.259 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.551387 | 0.259 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.551387 | 0.259 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.551387 | 0.259 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.551387 | 0.259 |
| R-HSA-186797 | Signaling by PDGF | 0.551387 | 0.259 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.556232 | 0.255 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.556506 | 0.255 |
| R-HSA-373755 | Semaphorin interactions | 0.556506 | 0.255 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.560086 | 0.252 |
| R-HSA-211981 | Xenobiotics | 0.561567 | 0.251 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.561567 | 0.251 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.561567 | 0.251 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.561567 | 0.251 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.566571 | 0.247 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.566571 | 0.247 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.571518 | 0.243 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.576390 | 0.239 |
| R-HSA-112040 | G-protein mediated events | 0.576408 | 0.239 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.576408 | 0.239 |
| R-HSA-69306 | DNA Replication | 0.582788 | 0.234 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.585961 | 0.232 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.589116 | 0.230 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.590750 | 0.229 |
| R-HSA-9612973 | Autophagy | 0.592253 | 0.227 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.595146 | 0.225 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.595422 | 0.225 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.595422 | 0.225 |
| R-HSA-1640170 | Cell Cycle | 0.596180 | 0.225 |
| R-HSA-9711097 | Cellular response to starvation | 0.598473 | 0.223 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.600041 | 0.222 |
| R-HSA-421270 | Cell-cell junction organization | 0.600111 | 0.222 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.604608 | 0.219 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.604608 | 0.219 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.604608 | 0.219 |
| R-HSA-9749641 | Aspirin ADME | 0.604608 | 0.219 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.604608 | 0.219 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.609123 | 0.215 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.609123 | 0.215 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.609123 | 0.215 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.610219 | 0.215 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 0.613587 | 0.212 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.616709 | 0.210 |
| R-HSA-5689603 | UCH proteinases | 0.617999 | 0.209 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.626676 | 0.203 |
| R-HSA-5619084 | ABC transporter disorders | 0.626676 | 0.203 |
| R-HSA-4086400 | PCP/CE pathway | 0.626676 | 0.203 |
| R-HSA-191273 | Cholesterol biosynthesis | 0.626676 | 0.203 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.635156 | 0.197 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.635156 | 0.197 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.637178 | 0.196 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.639324 | 0.194 |
| R-HSA-9018677 | Biosynthesis of DHA-derived SPMs | 0.639324 | 0.194 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.640031 | 0.194 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.642867 | 0.192 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.645686 | 0.190 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.645686 | 0.190 |
| R-HSA-9679506 | SARS-CoV Infections | 0.646829 | 0.189 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.647518 | 0.189 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.655527 | 0.183 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.659463 | 0.181 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.659463 | 0.181 |
| R-HSA-112316 | Neuronal System | 0.659684 | 0.181 |
| R-HSA-168255 | Influenza Infection | 0.662230 | 0.179 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.663355 | 0.178 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 0.663355 | 0.178 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.667203 | 0.176 |
| R-HSA-156902 | Peptide chain elongation | 0.671006 | 0.173 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.672548 | 0.172 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.672913 | 0.172 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.674767 | 0.171 |
| R-HSA-73884 | Base Excision Repair | 0.678484 | 0.168 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.682160 | 0.166 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.682160 | 0.166 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.682160 | 0.166 |
| R-HSA-74160 | Gene expression (Transcription) | 0.684356 | 0.165 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.685882 | 0.164 |
| R-HSA-391251 | Protein folding | 0.689386 | 0.162 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.689386 | 0.162 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.692937 | 0.159 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.696449 | 0.157 |
| R-HSA-1474290 | Collagen formation | 0.696449 | 0.157 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.699920 | 0.155 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.699920 | 0.155 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.699931 | 0.155 |
| R-HSA-1483257 | Phospholipid metabolism | 0.699931 | 0.155 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.703351 | 0.153 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.703351 | 0.153 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.703351 | 0.153 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.705758 | 0.151 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 0.706744 | 0.151 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.706744 | 0.151 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.706744 | 0.151 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.706744 | 0.151 |
| R-HSA-157579 | Telomere Maintenance | 0.710098 | 0.149 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.710098 | 0.149 |
| R-HSA-422356 | Regulation of insulin secretion | 0.713414 | 0.147 |
| R-HSA-190236 | Signaling by FGFR | 0.713414 | 0.147 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.716692 | 0.145 |
| R-HSA-70171 | Glycolysis | 0.719933 | 0.143 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.719933 | 0.143 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.722284 | 0.141 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.722284 | 0.141 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.723137 | 0.141 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.723137 | 0.141 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.726305 | 0.139 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.726305 | 0.139 |
| R-HSA-1483255 | PI Metabolism | 0.726305 | 0.139 |
| R-HSA-192823 | Viral mRNA Translation | 0.729436 | 0.137 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.732532 | 0.135 |
| R-HSA-111885 | Opioid Signalling | 0.732532 | 0.135 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.732532 | 0.135 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.734759 | 0.134 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.744567 | 0.128 |
| R-HSA-211000 | Gene Silencing by RNA | 0.744567 | 0.128 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.747491 | 0.126 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.747670 | 0.126 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.750381 | 0.125 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.752973 | 0.123 |
| R-HSA-8957322 | Metabolism of steroids | 0.754721 | 0.122 |
| R-HSA-418990 | Adherens junctions interactions | 0.757146 | 0.121 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.758856 | 0.120 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.761617 | 0.118 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.764347 | 0.117 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.769713 | 0.114 |
| R-HSA-162906 | HIV Infection | 0.775056 | 0.111 |
| R-HSA-70326 | Glucose metabolism | 0.777535 | 0.109 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.777535 | 0.109 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.780083 | 0.108 |
| R-HSA-72312 | rRNA processing | 0.784502 | 0.105 |
| R-HSA-68875 | Mitotic Prophase | 0.785093 | 0.105 |
| R-HSA-73886 | Chromosome Maintenance | 0.787555 | 0.104 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 0.787555 | 0.104 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.787555 | 0.104 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.792395 | 0.101 |
| R-HSA-9717207 | Sensory perception of sweet, bitter, and umami (glutamate) taste | 0.792395 | 0.101 |
| R-HSA-157118 | Signaling by NOTCH | 0.798895 | 0.098 |
| R-HSA-69481 | G2/M Checkpoints | 0.804022 | 0.095 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.806268 | 0.094 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.810684 | 0.091 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.810788 | 0.091 |
| R-HSA-382551 | Transport of small molecules | 0.814090 | 0.089 |
| R-HSA-9717189 | Sensory perception of taste | 0.815000 | 0.089 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.815457 | 0.089 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.817121 | 0.088 |
| R-HSA-109582 | Hemostasis | 0.817638 | 0.087 |
| R-HSA-5688426 | Deubiquitination | 0.823613 | 0.084 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.827370 | 0.082 |
| R-HSA-163685 | Integration of energy metabolism | 0.827370 | 0.082 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.827370 | 0.082 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.840765 | 0.075 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.840765 | 0.075 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.842570 | 0.074 |
| R-HSA-9018678 | Biosynthesis of specialized proresolving mediators (SPMs) | 0.842592 | 0.074 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.842802 | 0.074 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.844399 | 0.073 |
| R-HSA-2262752 | Cellular responses to stress | 0.845161 | 0.073 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.849695 | 0.071 |
| R-HSA-166520 | Signaling by NTRKs | 0.851420 | 0.070 |
| R-HSA-9758941 | Gastrulation | 0.853126 | 0.069 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.855355 | 0.068 |
| R-HSA-9609507 | Protein localization | 0.859756 | 0.066 |
| R-HSA-73887 | Death Receptor Signaling | 0.861366 | 0.065 |
| R-HSA-449147 | Signaling by Interleukins | 0.864342 | 0.063 |
| R-HSA-9610379 | HCMV Late Events | 0.866088 | 0.062 |
| R-HSA-162587 | HIV Life Cycle | 0.866088 | 0.062 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.867626 | 0.062 |
| R-HSA-418594 | G alpha (i) signalling events | 0.869295 | 0.061 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.870650 | 0.060 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.876493 | 0.057 |
| R-HSA-195721 | Signaling by WNT | 0.880083 | 0.055 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 0.880702 | 0.055 |
| R-HSA-5619102 | SLC transporter disorders | 0.880702 | 0.055 |
| R-HSA-199991 | Membrane Trafficking | 0.883321 | 0.054 |
| R-HSA-72306 | tRNA processing | 0.886093 | 0.053 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.889976 | 0.051 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.891953 | 0.050 |
| R-HSA-611105 | Respiratory electron transport | 0.896159 | 0.048 |
| R-HSA-2559583 | Cellular Senescence | 0.898534 | 0.046 |
| R-HSA-9609690 | HCMV Early Events | 0.915688 | 0.038 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.918074 | 0.037 |
| R-HSA-212436 | Generic Transcription Pathway | 0.918403 | 0.037 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.919498 | 0.036 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.919505 | 0.036 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.921349 | 0.036 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.921985 | 0.035 |
| R-HSA-68882 | Mitotic Anaphase | 0.933901 | 0.030 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.934663 | 0.029 |
| R-HSA-9748784 | Drug ADME | 0.935416 | 0.029 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.936401 | 0.029 |
| R-HSA-8939211 | ESR-mediated signaling | 0.948196 | 0.023 |
| R-HSA-168249 | Innate Immune System | 0.950163 | 0.022 |
| R-HSA-388396 | GPCR downstream signalling | 0.951840 | 0.021 |
| R-HSA-168256 | Immune System | 0.953548 | 0.021 |
| R-HSA-9609646 | HCMV Infection | 0.955457 | 0.020 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.959412 | 0.018 |
| R-HSA-416476 | G alpha (q) signalling events | 0.962148 | 0.017 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.962648 | 0.017 |
| R-HSA-1280218 | Adaptive Immune System | 0.963554 | 0.016 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.967838 | 0.014 |
| R-HSA-500792 | GPCR ligand binding | 0.971820 | 0.012 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.973569 | 0.012 |
| R-HSA-372790 | Signaling by GPCR | 0.974367 | 0.011 |
| R-HSA-9824446 | Viral Infection Pathways | 0.979372 | 0.009 |
| R-HSA-1474244 | Extracellular matrix organization | 0.982665 | 0.008 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.991411 | 0.004 |
| R-HSA-556833 | Metabolism of lipids | 0.991615 | 0.004 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.992088 | 0.003 |
| R-HSA-392499 | Metabolism of proteins | 0.992917 | 0.003 |
| R-HSA-8978868 | Fatty acid metabolism | 0.992964 | 0.003 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.994100 | 0.003 |
| R-HSA-597592 | Post-translational protein modification | 0.994293 | 0.002 |
| R-HSA-1643685 | Disease | 0.996239 | 0.002 |
| R-HSA-211859 | Biological oxidations | 0.998206 | 0.001 |
| R-HSA-5663205 | Infectious disease | 0.999357 | 0.000 |
| R-HSA-1430728 | Metabolism | 0.999999 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.870 | 0.152 | 2 | 0.856 |
CLK3 |
0.867 | 0.254 | 1 | 0.845 |
SRPK1 |
0.859 | 0.202 | -3 | 0.770 |
PIM3 |
0.858 | 0.139 | -3 | 0.840 |
CDC7 |
0.857 | 0.048 | 1 | 0.820 |
CAMK1B |
0.856 | 0.120 | -3 | 0.874 |
PIM1 |
0.854 | 0.192 | -3 | 0.786 |
RSK2 |
0.854 | 0.138 | -3 | 0.782 |
NLK |
0.854 | 0.138 | 1 | 0.851 |
MOS |
0.854 | 0.081 | 1 | 0.854 |
PRKD1 |
0.853 | 0.159 | -3 | 0.827 |
DSTYK |
0.853 | 0.045 | 2 | 0.873 |
WNK1 |
0.853 | 0.143 | -2 | 0.873 |
MTOR |
0.852 | -0.006 | 1 | 0.765 |
PRPK |
0.852 | -0.050 | -1 | 0.855 |
NUAK2 |
0.852 | 0.117 | -3 | 0.845 |
PRKD2 |
0.852 | 0.150 | -3 | 0.768 |
CDKL1 |
0.851 | 0.091 | -3 | 0.816 |
NDR1 |
0.851 | 0.093 | -3 | 0.836 |
GCN2 |
0.850 | -0.088 | 2 | 0.800 |
NDR2 |
0.850 | 0.053 | -3 | 0.841 |
PKN3 |
0.850 | 0.076 | -3 | 0.831 |
CAMK2G |
0.849 | 0.005 | 2 | 0.815 |
ERK5 |
0.849 | 0.094 | 1 | 0.822 |
HIPK4 |
0.849 | 0.138 | 1 | 0.827 |
KIS |
0.848 | 0.161 | 1 | 0.754 |
PKN2 |
0.848 | 0.096 | -3 | 0.847 |
SRPK2 |
0.848 | 0.159 | -3 | 0.689 |
RAF1 |
0.847 | -0.097 | 1 | 0.799 |
P90RSK |
0.847 | 0.090 | -3 | 0.783 |
CDKL5 |
0.847 | 0.091 | -3 | 0.803 |
CLK2 |
0.847 | 0.250 | -3 | 0.761 |
MARK4 |
0.847 | 0.077 | 4 | 0.780 |
NEK6 |
0.847 | 0.037 | -2 | 0.850 |
MAPKAPK3 |
0.846 | 0.083 | -3 | 0.776 |
NIK |
0.846 | 0.088 | -3 | 0.887 |
RSK3 |
0.846 | 0.089 | -3 | 0.782 |
BMPR2 |
0.846 | -0.071 | -2 | 0.856 |
MST4 |
0.845 | 0.047 | 2 | 0.813 |
CAMLCK |
0.845 | 0.088 | -2 | 0.850 |
SKMLCK |
0.845 | 0.091 | -2 | 0.865 |
AMPKA1 |
0.845 | 0.111 | -3 | 0.852 |
CLK1 |
0.845 | 0.196 | -3 | 0.760 |
ULK2 |
0.845 | -0.117 | 2 | 0.767 |
P70S6KB |
0.844 | 0.096 | -3 | 0.803 |
SRPK3 |
0.844 | 0.157 | -3 | 0.747 |
ATR |
0.844 | -0.007 | 1 | 0.804 |
CAMK2D |
0.844 | 0.049 | -3 | 0.840 |
TSSK2 |
0.844 | 0.142 | -5 | 0.893 |
PKCD |
0.844 | 0.093 | 2 | 0.773 |
MAPKAPK2 |
0.843 | 0.090 | -3 | 0.728 |
CLK4 |
0.843 | 0.169 | -3 | 0.779 |
PDHK4 |
0.843 | -0.258 | 1 | 0.809 |
DYRK2 |
0.842 | 0.165 | 1 | 0.775 |
AURC |
0.842 | 0.131 | -2 | 0.686 |
HUNK |
0.841 | -0.024 | 2 | 0.806 |
ICK |
0.841 | 0.086 | -3 | 0.846 |
IKKB |
0.841 | -0.153 | -2 | 0.715 |
AMPKA2 |
0.841 | 0.109 | -3 | 0.820 |
DAPK2 |
0.841 | 0.058 | -3 | 0.877 |
TSSK1 |
0.841 | 0.135 | -3 | 0.868 |
GRK5 |
0.840 | -0.085 | -3 | 0.869 |
PKACG |
0.840 | 0.076 | -2 | 0.756 |
NEK7 |
0.840 | -0.096 | -3 | 0.847 |
TBK1 |
0.840 | -0.129 | 1 | 0.686 |
PRKD3 |
0.840 | 0.121 | -3 | 0.765 |
PDHK1 |
0.839 | -0.196 | 1 | 0.792 |
PAK6 |
0.839 | 0.179 | -2 | 0.721 |
CDK8 |
0.839 | 0.110 | 1 | 0.728 |
NIM1 |
0.839 | 0.035 | 3 | 0.754 |
MNK2 |
0.839 | 0.098 | -2 | 0.810 |
GRK6 |
0.839 | 0.008 | 1 | 0.796 |
CAMK2A |
0.839 | 0.092 | 2 | 0.812 |
IKKE |
0.839 | -0.128 | 1 | 0.680 |
TGFBR2 |
0.838 | -0.055 | -2 | 0.765 |
LATS2 |
0.838 | 0.020 | -5 | 0.771 |
CHAK2 |
0.838 | -0.024 | -1 | 0.820 |
CDK13 |
0.837 | 0.145 | 1 | 0.722 |
JNK2 |
0.837 | 0.187 | 1 | 0.691 |
CAMK2B |
0.837 | 0.077 | 2 | 0.777 |
PKACB |
0.837 | 0.136 | -2 | 0.700 |
NEK9 |
0.837 | -0.033 | 2 | 0.825 |
CDK5 |
0.837 | 0.174 | 1 | 0.768 |
CDK7 |
0.836 | 0.111 | 1 | 0.746 |
QSK |
0.836 | 0.081 | 4 | 0.754 |
MLK1 |
0.836 | -0.098 | 2 | 0.793 |
BCKDK |
0.836 | -0.121 | -1 | 0.837 |
PAK1 |
0.836 | 0.062 | -2 | 0.781 |
FAM20C |
0.836 | 0.042 | 2 | 0.562 |
HIPK1 |
0.836 | 0.193 | 1 | 0.789 |
CDK18 |
0.835 | 0.164 | 1 | 0.693 |
RIPK3 |
0.835 | -0.093 | 3 | 0.707 |
GRK1 |
0.835 | 0.024 | -2 | 0.751 |
MELK |
0.835 | 0.066 | -3 | 0.805 |
CDK19 |
0.835 | 0.115 | 1 | 0.700 |
WNK3 |
0.835 | -0.157 | 1 | 0.775 |
PKCB |
0.835 | 0.081 | 2 | 0.739 |
HIPK2 |
0.834 | 0.182 | 1 | 0.704 |
IRE1 |
0.834 | 0.016 | 1 | 0.779 |
JNK3 |
0.834 | 0.159 | 1 | 0.719 |
PRKX |
0.834 | 0.153 | -3 | 0.683 |
SGK3 |
0.834 | 0.125 | -3 | 0.773 |
CAMK4 |
0.833 | -0.007 | -3 | 0.822 |
MSK2 |
0.833 | 0.034 | -3 | 0.756 |
AKT2 |
0.833 | 0.116 | -3 | 0.702 |
QIK |
0.833 | 0.015 | -3 | 0.838 |
PIM2 |
0.833 | 0.145 | -3 | 0.754 |
PKCA |
0.833 | 0.080 | 2 | 0.718 |
PKR |
0.833 | 0.082 | 1 | 0.823 |
RSK4 |
0.833 | 0.094 | -3 | 0.746 |
ATM |
0.833 | 0.001 | 1 | 0.752 |
ULK1 |
0.832 | -0.176 | -3 | 0.814 |
MARK3 |
0.832 | 0.076 | 4 | 0.724 |
P38A |
0.832 | 0.149 | 1 | 0.769 |
PAK3 |
0.832 | 0.016 | -2 | 0.783 |
CDK1 |
0.832 | 0.135 | 1 | 0.705 |
BMPR1B |
0.832 | 0.072 | 1 | 0.774 |
PKCG |
0.831 | 0.044 | 2 | 0.736 |
MNK1 |
0.831 | 0.079 | -2 | 0.824 |
SIK |
0.831 | 0.061 | -3 | 0.766 |
MSK1 |
0.831 | 0.080 | -3 | 0.760 |
NEK2 |
0.830 | 0.016 | 2 | 0.808 |
NUAK1 |
0.830 | 0.019 | -3 | 0.794 |
MASTL |
0.830 | -0.199 | -2 | 0.806 |
AURB |
0.830 | 0.086 | -2 | 0.680 |
DNAPK |
0.830 | 0.072 | 1 | 0.690 |
CDK12 |
0.830 | 0.137 | 1 | 0.694 |
RIPK1 |
0.829 | -0.137 | 1 | 0.785 |
DYRK4 |
0.829 | 0.168 | 1 | 0.709 |
CDK9 |
0.829 | 0.121 | 1 | 0.729 |
MLK2 |
0.829 | -0.098 | 2 | 0.800 |
GRK4 |
0.829 | -0.102 | -2 | 0.801 |
MLK3 |
0.829 | -0.025 | 2 | 0.736 |
LATS1 |
0.829 | 0.044 | -3 | 0.858 |
HIPK3 |
0.829 | 0.164 | 1 | 0.779 |
CDK10 |
0.829 | 0.199 | 1 | 0.725 |
MYLK4 |
0.828 | 0.053 | -2 | 0.786 |
ANKRD3 |
0.828 | -0.125 | 1 | 0.824 |
P38G |
0.828 | 0.153 | 1 | 0.631 |
TTBK2 |
0.828 | -0.126 | 2 | 0.729 |
PKCZ |
0.828 | 0.038 | 2 | 0.776 |
PKG2 |
0.827 | 0.082 | -2 | 0.703 |
BRSK1 |
0.827 | 0.007 | -3 | 0.800 |
CAMK1G |
0.827 | 0.056 | -3 | 0.769 |
PKCH |
0.826 | 0.030 | 2 | 0.716 |
MARK2 |
0.826 | 0.034 | 4 | 0.687 |
PLK1 |
0.826 | -0.042 | -2 | 0.796 |
P38B |
0.826 | 0.136 | 1 | 0.701 |
DYRK1B |
0.826 | 0.150 | 1 | 0.739 |
ALK4 |
0.825 | -0.058 | -2 | 0.767 |
CDK2 |
0.825 | 0.073 | 1 | 0.768 |
DLK |
0.825 | -0.224 | 1 | 0.772 |
IRE2 |
0.825 | -0.008 | 2 | 0.725 |
IKKA |
0.825 | -0.121 | -2 | 0.695 |
GRK7 |
0.825 | 0.030 | 1 | 0.739 |
CDK14 |
0.825 | 0.157 | 1 | 0.733 |
CDK16 |
0.825 | 0.169 | 1 | 0.658 |
TGFBR1 |
0.824 | -0.031 | -2 | 0.732 |
DYRK3 |
0.824 | 0.151 | 1 | 0.792 |
CDK3 |
0.824 | 0.149 | 1 | 0.661 |
CDK17 |
0.824 | 0.122 | 1 | 0.640 |
ERK1 |
0.824 | 0.115 | 1 | 0.699 |
CHK1 |
0.824 | 0.039 | -3 | 0.814 |
PHKG1 |
0.823 | -0.026 | -3 | 0.825 |
DYRK1A |
0.823 | 0.110 | 1 | 0.785 |
MPSK1 |
0.823 | 0.221 | 1 | 0.832 |
VRK2 |
0.823 | -0.091 | 1 | 0.846 |
DCAMKL1 |
0.822 | 0.061 | -3 | 0.790 |
MARK1 |
0.822 | 0.014 | 4 | 0.739 |
CHAK1 |
0.822 | -0.074 | 2 | 0.763 |
BRSK2 |
0.822 | -0.035 | -3 | 0.817 |
PKACA |
0.822 | 0.108 | -2 | 0.657 |
AKT1 |
0.822 | 0.106 | -3 | 0.716 |
MEK1 |
0.821 | -0.157 | 2 | 0.814 |
PRP4 |
0.821 | 0.066 | -3 | 0.756 |
PAK2 |
0.821 | -0.019 | -2 | 0.767 |
MLK4 |
0.821 | -0.068 | 2 | 0.714 |
PERK |
0.821 | -0.027 | -2 | 0.819 |
PLK3 |
0.821 | -0.038 | 2 | 0.765 |
WNK4 |
0.821 | 0.018 | -2 | 0.869 |
YSK4 |
0.821 | -0.119 | 1 | 0.718 |
ALK2 |
0.820 | -0.014 | -2 | 0.750 |
HRI |
0.820 | -0.038 | -2 | 0.830 |
ACVR2B |
0.820 | -0.008 | -2 | 0.764 |
AURA |
0.820 | 0.042 | -2 | 0.648 |
SMG1 |
0.820 | -0.054 | 1 | 0.759 |
ACVR2A |
0.819 | -0.022 | -2 | 0.755 |
DRAK1 |
0.818 | -0.061 | 1 | 0.730 |
PINK1 |
0.818 | -0.047 | 1 | 0.849 |
MAPKAPK5 |
0.818 | -0.065 | -3 | 0.727 |
PKCT |
0.818 | 0.038 | 2 | 0.721 |
P70S6K |
0.817 | 0.045 | -3 | 0.718 |
CAMK1D |
0.817 | 0.082 | -3 | 0.690 |
ERK2 |
0.817 | 0.069 | 1 | 0.724 |
MST3 |
0.817 | 0.041 | 2 | 0.823 |
SSTK |
0.816 | 0.058 | 4 | 0.729 |
SMMLCK |
0.816 | 0.031 | -3 | 0.831 |
IRAK4 |
0.816 | -0.011 | 1 | 0.779 |
BRAF |
0.816 | -0.067 | -4 | 0.818 |
GAK |
0.815 | 0.220 | 1 | 0.889 |
NEK5 |
0.815 | 0.006 | 1 | 0.804 |
P38D |
0.815 | 0.140 | 1 | 0.662 |
PKCI |
0.815 | 0.054 | 2 | 0.740 |
MEKK1 |
0.814 | -0.082 | 1 | 0.767 |
ERK7 |
0.814 | 0.104 | 2 | 0.573 |
PHKG2 |
0.814 | 0.007 | -3 | 0.808 |
GSK3A |
0.813 | 0.068 | 4 | 0.464 |
PKCE |
0.813 | 0.088 | 2 | 0.720 |
GSK3B |
0.813 | 0.030 | 4 | 0.450 |
TLK2 |
0.813 | -0.124 | 1 | 0.756 |
PAK5 |
0.813 | 0.073 | -2 | 0.655 |
SNRK |
0.812 | -0.176 | 2 | 0.647 |
MAK |
0.812 | 0.159 | -2 | 0.702 |
DCAMKL2 |
0.812 | -0.008 | -3 | 0.814 |
CDK6 |
0.812 | 0.153 | 1 | 0.720 |
MEK5 |
0.811 | -0.201 | 2 | 0.798 |
MEKK2 |
0.811 | -0.071 | 2 | 0.786 |
PAK4 |
0.811 | 0.093 | -2 | 0.659 |
BUB1 |
0.811 | 0.205 | -5 | 0.888 |
PLK4 |
0.811 | -0.117 | 2 | 0.615 |
MEKK3 |
0.810 | -0.167 | 1 | 0.755 |
PKN1 |
0.810 | 0.057 | -3 | 0.735 |
AKT3 |
0.810 | 0.103 | -3 | 0.637 |
TAO3 |
0.810 | -0.027 | 1 | 0.750 |
ZAK |
0.810 | -0.140 | 1 | 0.717 |
GRK2 |
0.810 | -0.091 | -2 | 0.660 |
DAPK3 |
0.809 | 0.077 | -3 | 0.807 |
SGK1 |
0.809 | 0.102 | -3 | 0.621 |
MOK |
0.809 | 0.156 | 1 | 0.806 |
CAMK1A |
0.809 | 0.097 | -3 | 0.668 |
TLK1 |
0.809 | -0.113 | -2 | 0.789 |
BMPR1A |
0.809 | -0.005 | 1 | 0.757 |
TNIK |
0.809 | 0.107 | 3 | 0.870 |
CAMKK1 |
0.808 | -0.077 | -2 | 0.764 |
CDK4 |
0.808 | 0.134 | 1 | 0.686 |
LKB1 |
0.808 | 0.006 | -3 | 0.829 |
PASK |
0.808 | -0.016 | -3 | 0.860 |
CK2A2 |
0.808 | 0.052 | 1 | 0.681 |
JNK1 |
0.807 | 0.106 | 1 | 0.681 |
CK1E |
0.807 | -0.030 | -3 | 0.574 |
TAO2 |
0.807 | -0.021 | 2 | 0.832 |
PBK |
0.806 | 0.222 | 1 | 0.846 |
MRCKB |
0.806 | 0.098 | -3 | 0.747 |
HGK |
0.805 | 0.041 | 3 | 0.865 |
NEK4 |
0.805 | -0.019 | 1 | 0.756 |
CHK2 |
0.804 | 0.052 | -3 | 0.648 |
SBK |
0.804 | 0.089 | -3 | 0.579 |
NEK8 |
0.804 | -0.122 | 2 | 0.799 |
CAMKK2 |
0.803 | -0.083 | -2 | 0.764 |
GCK |
0.803 | 0.000 | 1 | 0.760 |
ROCK2 |
0.803 | 0.108 | -3 | 0.791 |
HPK1 |
0.802 | 0.026 | 1 | 0.743 |
NEK1 |
0.802 | 0.052 | 1 | 0.771 |
DAPK1 |
0.802 | 0.047 | -3 | 0.793 |
IRAK1 |
0.802 | -0.201 | -1 | 0.790 |
MINK |
0.802 | 0.004 | 1 | 0.745 |
PDK1 |
0.801 | -0.055 | 1 | 0.769 |
DMPK1 |
0.801 | 0.151 | -3 | 0.769 |
EEF2K |
0.801 | 0.019 | 3 | 0.845 |
NEK11 |
0.800 | -0.174 | 1 | 0.744 |
LRRK2 |
0.800 | -0.040 | 2 | 0.834 |
MEKK6 |
0.800 | -0.038 | 1 | 0.742 |
MRCKA |
0.800 | 0.065 | -3 | 0.759 |
CK1D |
0.799 | -0.027 | -3 | 0.521 |
TTBK1 |
0.799 | -0.184 | 2 | 0.645 |
BIKE |
0.799 | 0.274 | 1 | 0.829 |
KHS1 |
0.799 | 0.067 | 1 | 0.738 |
LOK |
0.799 | -0.018 | -2 | 0.776 |
KHS2 |
0.798 | 0.086 | 1 | 0.752 |
CK1G1 |
0.798 | -0.065 | -3 | 0.580 |
TAK1 |
0.797 | -0.097 | 1 | 0.774 |
CK1A2 |
0.797 | -0.031 | -3 | 0.522 |
MST2 |
0.796 | -0.109 | 1 | 0.763 |
CK2A1 |
0.795 | 0.021 | 1 | 0.655 |
VRK1 |
0.795 | -0.090 | 2 | 0.820 |
GRK3 |
0.794 | -0.089 | -2 | 0.610 |
PLK2 |
0.793 | -0.022 | -3 | 0.818 |
MAP3K15 |
0.793 | -0.108 | 1 | 0.709 |
YSK1 |
0.793 | -0.016 | 2 | 0.795 |
ROCK1 |
0.792 | 0.091 | -3 | 0.757 |
STK33 |
0.790 | -0.135 | 2 | 0.606 |
MST1 |
0.790 | -0.109 | 1 | 0.742 |
CRIK |
0.789 | 0.100 | -3 | 0.708 |
PDHK3_TYR |
0.789 | 0.222 | 4 | 0.845 |
HASPIN |
0.788 | 0.048 | -1 | 0.704 |
PKG1 |
0.787 | 0.023 | -2 | 0.633 |
SLK |
0.787 | -0.105 | -2 | 0.704 |
AAK1 |
0.787 | 0.306 | 1 | 0.757 |
MYO3B |
0.786 | 0.053 | 2 | 0.808 |
NEK3 |
0.785 | -0.092 | 1 | 0.718 |
MEK2 |
0.784 | -0.229 | 2 | 0.788 |
TTK |
0.783 | 0.022 | -2 | 0.807 |
RIPK2 |
0.781 | -0.285 | 1 | 0.682 |
TESK1_TYR |
0.779 | -0.001 | 3 | 0.866 |
OSR1 |
0.778 | -0.092 | 2 | 0.767 |
MAP2K4_TYR |
0.778 | 0.016 | -1 | 0.875 |
PKMYT1_TYR |
0.778 | 0.048 | 3 | 0.821 |
MAP2K6_TYR |
0.777 | 0.023 | -1 | 0.880 |
PDHK4_TYR |
0.776 | 0.001 | 2 | 0.842 |
MYO3A |
0.776 | -0.043 | 1 | 0.747 |
LIMK2_TYR |
0.776 | 0.065 | -3 | 0.885 |
TAO1 |
0.775 | -0.064 | 1 | 0.674 |
MAP2K7_TYR |
0.774 | -0.148 | 2 | 0.834 |
BMPR2_TYR |
0.774 | -0.018 | -1 | 0.863 |
ASK1 |
0.773 | -0.134 | 1 | 0.692 |
PINK1_TYR |
0.771 | -0.118 | 1 | 0.799 |
ALPHAK3 |
0.771 | -0.076 | -1 | 0.773 |
EPHA6 |
0.770 | 0.020 | -1 | 0.848 |
PDHK1_TYR |
0.769 | -0.110 | -1 | 0.877 |
LIMK1_TYR |
0.768 | -0.080 | 2 | 0.829 |
YANK3 |
0.768 | -0.088 | 2 | 0.407 |
EPHB4 |
0.767 | -0.007 | -1 | 0.834 |
RET |
0.766 | -0.104 | 1 | 0.756 |
ABL2 |
0.762 | -0.002 | -1 | 0.810 |
TYK2 |
0.762 | -0.155 | 1 | 0.753 |
MST1R |
0.761 | -0.151 | 3 | 0.778 |
TYRO3 |
0.761 | -0.138 | 3 | 0.774 |
TXK |
0.759 | 0.028 | 1 | 0.792 |
TNNI3K_TYR |
0.759 | 0.031 | 1 | 0.764 |
ABL1 |
0.759 | -0.018 | -1 | 0.806 |
ROS1 |
0.759 | -0.138 | 3 | 0.746 |
DDR1 |
0.758 | -0.159 | 4 | 0.740 |
FGR |
0.758 | -0.047 | 1 | 0.829 |
YES1 |
0.758 | -0.021 | -1 | 0.813 |
JAK2 |
0.758 | -0.171 | 1 | 0.745 |
CK1A |
0.757 | -0.075 | -3 | 0.434 |
ITK |
0.756 | -0.057 | -1 | 0.797 |
CSF1R |
0.756 | -0.142 | 3 | 0.757 |
LCK |
0.756 | 0.036 | -1 | 0.800 |
TNK2 |
0.756 | -0.050 | 3 | 0.709 |
BLK |
0.755 | 0.072 | -1 | 0.805 |
EPHA4 |
0.755 | -0.056 | 2 | 0.754 |
HCK |
0.755 | -0.043 | -1 | 0.801 |
JAK3 |
0.755 | -0.149 | 1 | 0.726 |
FER |
0.755 | -0.132 | 1 | 0.831 |
STLK3 |
0.754 | -0.251 | 1 | 0.685 |
SRMS |
0.754 | -0.092 | 1 | 0.801 |
EPHB3 |
0.753 | -0.072 | -1 | 0.821 |
EPHB2 |
0.753 | -0.057 | -1 | 0.817 |
WEE1_TYR |
0.752 | -0.035 | -1 | 0.755 |
NEK10_TYR |
0.752 | -0.113 | 1 | 0.628 |
EPHB1 |
0.752 | -0.108 | 1 | 0.789 |
TNK1 |
0.752 | -0.076 | 3 | 0.752 |
INSRR |
0.751 | -0.138 | 3 | 0.708 |
MERTK |
0.750 | -0.088 | 3 | 0.741 |
PDGFRB |
0.749 | -0.197 | 3 | 0.774 |
FGFR2 |
0.749 | -0.186 | 3 | 0.753 |
JAK1 |
0.749 | -0.083 | 1 | 0.688 |
AXL |
0.748 | -0.137 | 3 | 0.738 |
BMX |
0.748 | -0.056 | -1 | 0.709 |
KDR |
0.747 | -0.145 | 3 | 0.719 |
FLT3 |
0.747 | -0.184 | 3 | 0.774 |
KIT |
0.746 | -0.185 | 3 | 0.757 |
TEK |
0.746 | -0.194 | 3 | 0.699 |
TEC |
0.745 | -0.100 | -1 | 0.728 |
FYN |
0.745 | 0.009 | -1 | 0.763 |
BTK |
0.744 | -0.191 | -1 | 0.760 |
PTK6 |
0.743 | -0.186 | -1 | 0.745 |
EPHA1 |
0.743 | -0.115 | 3 | 0.731 |
EPHA7 |
0.743 | -0.106 | 2 | 0.759 |
EPHA3 |
0.742 | -0.142 | 2 | 0.731 |
FGFR1 |
0.742 | -0.233 | 3 | 0.725 |
MET |
0.741 | -0.171 | 3 | 0.745 |
LTK |
0.741 | -0.155 | 3 | 0.691 |
PDGFRA |
0.740 | -0.268 | 3 | 0.771 |
DDR2 |
0.739 | -0.068 | 3 | 0.679 |
ALK |
0.739 | -0.190 | 3 | 0.670 |
FLT1 |
0.739 | -0.173 | -1 | 0.825 |
PTK2B |
0.738 | -0.087 | -1 | 0.776 |
FRK |
0.737 | -0.141 | -1 | 0.816 |
NTRK1 |
0.737 | -0.240 | -1 | 0.812 |
LYN |
0.737 | -0.103 | 3 | 0.674 |
EPHA5 |
0.736 | -0.099 | 2 | 0.737 |
CK1G3 |
0.736 | -0.091 | -3 | 0.389 |
MATK |
0.735 | -0.142 | -1 | 0.749 |
FGFR3 |
0.735 | -0.222 | 3 | 0.721 |
ERBB2 |
0.734 | -0.234 | 1 | 0.707 |
INSR |
0.734 | -0.211 | 3 | 0.686 |
FLT4 |
0.733 | -0.243 | 3 | 0.710 |
SRC |
0.733 | -0.069 | -1 | 0.772 |
NTRK2 |
0.733 | -0.267 | 3 | 0.717 |
EPHA8 |
0.731 | -0.137 | -1 | 0.802 |
NTRK3 |
0.730 | -0.193 | -1 | 0.768 |
YANK2 |
0.729 | -0.132 | 2 | 0.416 |
CSK |
0.729 | -0.187 | 2 | 0.759 |
EGFR |
0.729 | -0.134 | 1 | 0.609 |
PTK2 |
0.728 | -0.057 | -1 | 0.758 |
SYK |
0.724 | -0.074 | -1 | 0.750 |
MUSK |
0.723 | -0.169 | 1 | 0.613 |
FGFR4 |
0.722 | -0.178 | -1 | 0.773 |
EPHA2 |
0.720 | -0.148 | -1 | 0.768 |
IGF1R |
0.715 | -0.208 | 3 | 0.619 |
ERBB4 |
0.712 | -0.142 | 1 | 0.634 |
CK1G2 |
0.710 | -0.113 | -3 | 0.490 |
FES |
0.705 | -0.201 | -1 | 0.697 |
ZAP70 |
0.700 | -0.114 | -1 | 0.693 |