Motif 863 (n=262)

Position-wise Probabilities

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uniprot genes site source protein function
A0FGR8 ESYT2 S693 ochoa Extended synaptotagmin-2 (E-Syt2) (Chr2Syt) Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex. Promotes the localization of SACM1L at endoplasmic reticulum-plasma membrane contact sites (EPCS) (PubMed:27044890). {ECO:0000269|PubMed:17360437, ECO:0000269|PubMed:20833364, ECO:0000269|PubMed:23791178, ECO:0000269|PubMed:24847877, ECO:0000269|PubMed:27044890}.
F8WAN1 SPECC1L-ADORA2A S392 ochoa SPECC1L-ADORA2A readthrough (NMD candidate) None
O14639 ABLIM1 S677 ochoa Actin-binding LIM protein 1 (abLIM-1) (Actin-binding LIM protein family member 1) (Actin-binding double zinc finger protein) (LIMAB1) (Limatin) May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance. {ECO:0000250, ECO:0000269|PubMed:9245787}.
O14640 DVL1 S119 ochoa Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1) Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).
O14757 CHEK1 S288 ochoa Serine/threonine-protein kinase Chk1 (EC 2.7.11.1) (CHK1 checkpoint homolog) (Cell cycle checkpoint kinase) (Checkpoint kinase-1) Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA (PubMed:11535615, PubMed:12399544, PubMed:12446774, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15650047, PubMed:15665856, PubMed:32357935). May also negatively regulate cell cycle progression during unperturbed cell cycles (PubMed:11535615, PubMed:12399544, PubMed:12446774, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15650047, PubMed:15665856). This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome (PubMed:11535615, PubMed:12399544, PubMed:12446774, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15650047, PubMed:15665856). Recognizes the substrate consensus sequence [R-X-X-S/T] (PubMed:11535615, PubMed:12399544, PubMed:12446774, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15650047, PubMed:15665856). Binds to and phosphorylates CDC25A, CDC25B and CDC25C (PubMed:12676583, PubMed:12676925, PubMed:12759351, PubMed:14559997, PubMed:14681206, PubMed:19734889, PubMed:9278511). Phosphorylation of CDC25A at 'Ser-178' and 'Thr-507' and phosphorylation of CDC25C at 'Ser-216' creates binding sites for 14-3-3 proteins which inhibit CDC25A and CDC25C (PubMed:9278511). Phosphorylation of CDC25A at 'Ser-76', 'Ser-124', 'Ser-178', 'Ser-279' and 'Ser-293' promotes proteolysis of CDC25A (PubMed:12676583, PubMed:12676925, PubMed:12759351, PubMed:14681206, PubMed:19734889, PubMed:9278511). Phosphorylation of CDC25A at 'Ser-76' primes the protein for subsequent phosphorylation at 'Ser-79', 'Ser-82' and 'Ser-88' by NEK11, which is required for polyubiquitination and degradation of CDCD25A (PubMed:19734889, PubMed:20090422, PubMed:9278511). Inhibition of CDC25 leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression (PubMed:9278511). Also phosphorylates NEK6 (PubMed:18728393). Binds to and phosphorylates RAD51 at 'Thr-309', which promotes the release of RAD51 from BRCA2 and enhances the association of RAD51 with chromatin, thereby promoting DNA repair by homologous recombination (PubMed:15665856). Phosphorylates multiple sites within the C-terminus of TP53, which promotes activation of TP53 by acetylation and promotes cell cycle arrest and suppression of cellular proliferation (PubMed:10673501, PubMed:15659650, PubMed:16511572). Also promotes repair of DNA cross-links through phosphorylation of FANCE (PubMed:17296736). Binds to and phosphorylates TLK1 at 'Ser-743', which prevents the TLK1-dependent phosphorylation of the chromatin assembly factor ASF1A (PubMed:12660173, PubMed:12955071). This may enhance chromatin assembly both in the presence or absence of DNA damage (PubMed:12660173, PubMed:12955071). May also play a role in replication fork maintenance through regulation of PCNA (PubMed:18451105). May regulate the transcription of genes that regulate cell-cycle progression through the phosphorylation of histones (By similarity). Phosphorylates histone H3.1 (to form H3T11ph), which leads to epigenetic inhibition of a subset of genes (By similarity). May also phosphorylate RB1 to promote its interaction with the E2F family of transcription factors and subsequent cell cycle arrest (PubMed:17380128). Phosphorylates SPRTN, promoting SPRTN recruitment to chromatin (PubMed:31316063). Reduces replication stress and activates the G2/M checkpoint, by phosphorylating and inactivating PABIR1/FAM122A and promoting the serine/threonine-protein phosphatase 2A-mediated dephosphorylation and stabilization of WEE1 levels and activity (PubMed:33108758). {ECO:0000250|UniProtKB:O35280, ECO:0000269|PubMed:10673501, ECO:0000269|PubMed:11535615, ECO:0000269|PubMed:12399544, ECO:0000269|PubMed:12446774, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:12676583, ECO:0000269|PubMed:12676925, ECO:0000269|PubMed:12759351, ECO:0000269|PubMed:12955071, ECO:0000269|PubMed:14559997, ECO:0000269|PubMed:14681206, ECO:0000269|PubMed:14988723, ECO:0000269|PubMed:15311285, ECO:0000269|PubMed:15650047, ECO:0000269|PubMed:15659650, ECO:0000269|PubMed:15665856, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:17296736, ECO:0000269|PubMed:17380128, ECO:0000269|PubMed:18451105, ECO:0000269|PubMed:18728393, ECO:0000269|PubMed:19734889, ECO:0000269|PubMed:20090422, ECO:0000269|PubMed:31316063, ECO:0000269|PubMed:32357935, ECO:0000269|PubMed:33108758, ECO:0000269|PubMed:9278511}.; FUNCTION: [Isoform 2]: Endogenous repressor of isoform 1, interacts with, and antagonizes CHK1 to promote the S to G2/M phase transition. {ECO:0000269|PubMed:22184239}.
O14974 PPP1R12A S678 psp Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity. {ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:19245366, ECO:0000269|PubMed:20354225}.
O14976 GAK S834 ochoa Cyclin-G-associated kinase (EC 2.7.11.1) (DnaJ homolog subfamily C member 26) Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 (PubMed:10625686). May play a role in clathrin-mediated endocytosis and intracellular trafficking, and in the dynamics of clathrin assembly/disassembly (PubMed:18489706). {ECO:0000269|PubMed:10625686, ECO:0000269|PubMed:18489706}.
O15211 RGL2 S745 ochoa Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like 2) (RalGDS-like factor) (Ras-associated protein RAB2L) Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the GTP-bound form of Rap 1A and H-Ras in vitro (By similarity). {ECO:0000250}.
O15234 CASC3 S363 ochoa Protein CASC3 (Cancer susceptibility candidate gene 3 protein) (Metastatic lymph node gene 51 protein) (MLN 51) (Protein barentsz) (Btz) Required for pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:29301961). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA-helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Binds poly(G) and poly(U) RNA homomer. {ECO:0000269|PubMed:17375189, ECO:0000269|PubMed:17652158, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961}.
O15409 FOXP2 S339 ochoa Forkhead box protein P2 (CAG repeat protein 44) (Trinucleotide repeat-containing gene 10 protein) Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. Involved in neural mechanisms mediating the development of speech and language.
O15516 CLOCK S449 ochoa Circadian locomoter output cycles protein kaput (hCLOCK) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 8) (bHLHe8) Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Regulates the circadian expression of ICAM1, VCAM1, CCL2, THPO and MPL and also acts as an enhancer of the transactivation potential of NF-kappaB. Plays an important role in the homeostatic regulation of sleep. The CLOCK-BMAL1 heterodimer regulates the circadian expression of SERPINE1/PAI1, VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1, GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1, ATF4, MTA1, KLF10 and also genes implicated in glucose and lipid metabolism. Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors. The CLOCK-BMAL2 heterodimer activates the transcription of SERPINE1/PAI1 and BHLHE40/DEC1. The preferred binding motif for the CLOCK-BMAL1 heterodimer is 5'-CACGTGA-3', which contains a flanking adenine nucleotide at the 3-prime end of the canonical 6-nucleotide E-box sequence (PubMed:23229515). CLOCK specifically binds to the half-site 5'-CAC-3', while BMAL1 binds to the half-site 5'-GTGA-3' (PubMed:23229515). The CLOCK-BMAL1 heterodimer also recognizes the non-canonical E-box motifs 5'-AACGTGA-3' and 5'-CATGTGA-3' (PubMed:23229515). CLOCK has an intrinsic acetyltransferase activity, which enables circadian chromatin remodeling by acetylating histones and nonhistone proteins, including its own partner BMAL1. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) via the acetylation of multiple lysine residues located in its hinge region (PubMed:21980503). The acetyltransferase activity of CLOCK is as important as its transcription activity in circadian control. Acetylates metabolic enzymes IMPDH2 and NDUFA9 in a circadian manner. Facilitated by BMAL1, rhythmically interacts and acetylates argininosuccinate synthase 1 (ASS1) leading to enzymatic inhibition of ASS1 as well as the circadian oscillation of arginine biosynthesis and subsequent ureagenesis (PubMed:28985504). Drives the circadian rhythm of blood pressure through transcriptional activation of ATP1B1 (By similarity). {ECO:0000250|UniProtKB:O08785, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:18587630, ECO:0000269|PubMed:21659603, ECO:0000269|PubMed:21980503, ECO:0000269|PubMed:22284746, ECO:0000269|PubMed:23229515, ECO:0000269|PubMed:23785138, ECO:0000269|PubMed:24005054, ECO:0000269|PubMed:28985504}.
O43166 SIPA1L1 S1178 ochoa Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}.
O43464 HTRA2 S350 ochoa Serine protease HTRA2, mitochondrial (EC 3.4.21.108) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine protease 25) (Serine proteinase OMI) [Isoform 1]: Serine protease that shows proteolytic activity against a non-specific substrate beta-casein (PubMed:10873535). Promotes apoptosis by either relieving the inhibition of BIRC proteins on caspases, leading to an increase in caspase activity; or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism (PubMed:15200957). Cleaves BIRC6 and relieves its inhibition on CASP3, CASP7 and CASP9, but it is also prone to inhibition by BIRC6 (PubMed:36758104, PubMed:36758105). Cleaves THAP5 and promotes its degradation during apoptosis (PubMed:19502560). {ECO:0000269|PubMed:10873535, ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:19502560, ECO:0000269|PubMed:36758104, ECO:0000269|PubMed:36758105}.; FUNCTION: [Isoform 2]: Seems to be proteolytically inactive. {ECO:0000269|PubMed:10995577}.
O43561 LAT S109 ochoa Linker for activation of T-cells family member 1 (36 kDa phosphotyrosine adapter protein) (pp36) (p36-38) Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development (PubMed:23514740, PubMed:25907557). Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules. {ECO:0000269|PubMed:10072481, ECO:0000269|PubMed:23514740, ECO:0000269|PubMed:25907557}.
O60293 ZFC3H1 S510 ochoa Zinc finger C3H1 domain-containing protein (Coiled-coil domain-containing protein 131) (Proline/serine-rich coiled-coil protein 2) Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters. {ECO:0000269|PubMed:27871484}.
O60318 MCM3AP S430 ochoa Germinal-center associated nuclear protein (GANP) (EC 2.3.1.48) (80 kDa MCM3-associated protein) (MCM3 acetylating protein) (MCM3AP) (EC 2.3.1.-) (MCM3 acetyltransferase) [Isoform GANP]: As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:20005110, PubMed:20384790, PubMed:22307388, PubMed:23591820). Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations (PubMed:23652018). {ECO:0000269|PubMed:20005110, ECO:0000269|PubMed:20384790, ECO:0000269|PubMed:22307388, ECO:0000269|PubMed:23591820, ECO:0000269|PubMed:23652018}.; FUNCTION: [Isoform MCM3AP]: Binds to and acetylates the replication protein MCM3. Plays a role in the initiation of DNA replication and participates in controls that ensure that DNA replication initiates only once per cell cycle (PubMed:11258703, PubMed:12226073). Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations (PubMed:23652018). {ECO:0000269|PubMed:11258703, ECO:0000269|PubMed:12226073, ECO:0000269|PubMed:23652018}.
O60336 MAPKBP1 S1254 ochoa Mitogen-activated protein kinase-binding protein 1 (JNK-binding protein 1) (JNKBP-1) Negative regulator of NOD2 function. It down-regulates NOD2-induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response (PubMed:22700971). Involved in JNK signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q6NS57, ECO:0000269|PubMed:22700971}.
O60343 TBC1D4 S648 ochoa TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160) May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake. {ECO:0000269|PubMed:15971998, ECO:0000269|PubMed:18771725, ECO:0000269|PubMed:22908308}.
O60841 EIF5B S190 ochoa Eukaryotic translation initiation factor 5B (eIF-5B) (EC 3.6.5.3) (Translation initiation factor IF-2) Plays a role in translation initiation (PubMed:10659855, PubMed:35732735). Ribosome-dependent GTPase that promotes the joining of the 60S ribosomal subunit to the pre-initiation complex to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon (PubMed:10659855, PubMed:35732735). Together with eIF1A (EIF1AX), actively orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex (PubMed:12569173, PubMed:35732735). Is released after formation of the 80S initiation complex (PubMed:35732735). Its GTPase activity is not essential for ribosomal subunits joining, but GTP hydrolysis is needed for eIF1A (EIF1AX) ejection quickly followed by EIF5B release to form elongation-competent ribosomes (PubMed:10659855, PubMed:35732735). In contrast to its procaryotic homolog, does not promote recruitment of Met-rRNA to the small ribosomal subunit (PubMed:10659855). {ECO:0000269|PubMed:10659855, ECO:0000269|PubMed:12569173, ECO:0000269|PubMed:35732735}.
O75121 MFAP3L S306 ochoa Microfibrillar-associated protein 3-like (Testis development protein NYD-SP9) May participate in the nuclear signaling of EGFR and MAPK1/ERK2. May a have a role in metastasis. {ECO:0000269|PubMed:24735981}.
O75369 FLNB S2486 ochoa Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.
O75385 ULK1 S783 ochoa Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1) Serine/threonine-protein kinase involved in autophagy in response to starvation (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:23524951, PubMed:25040165, PubMed:29487085, PubMed:31123703). Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165). Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR (PubMed:21795849). Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity (PubMed:21460634). May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences (PubMed:18936157). Plays a role early in neuronal differentiation and is required for granule cell axon formation (PubMed:11146101). Also phosphorylates SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165, PubMed:37306101). Phosphorylates FLCN, promoting autophagy (PubMed:25126726). Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation (PubMed:20921139). Phosphorylates ATG4B, leading to inhibit autophagy by decreasing both proteolytic activation and delipidation activities of ATG4B (PubMed:28821708). {ECO:0000269|PubMed:11146101, ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:20921139, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:25040165, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:28821708, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:31123703, ECO:0000269|PubMed:37306101}.
O75400 PRPF40A S42 ochoa Pre-mRNA-processing factor 40 homolog A (Fas ligand-associated factor 1) (Formin-binding protein 11) (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein 10) (HIP-10) (Huntingtin-interacting protein A) (Renal carcinoma antigen NY-REN-6) Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing. {ECO:0000250, ECO:0000269|PubMed:21834987}.
O75449 KATNA1 S117 ochoa Katanin p60 ATPase-containing subunit A1 (Katanin p60 subunit A1) (EC 5.6.1.1) (p60 katanin) Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. {ECO:0000255|HAMAP-Rule:MF_03023, ECO:0000269|PubMed:10751153, ECO:0000269|PubMed:11870226, ECO:0000269|PubMed:19287380}.
O75563 SKAP2 S291 ochoa Src kinase-associated phosphoprotein 2 (Pyk2/RAFTK-associated protein) (Retinoic acid-induced protein 70) (SKAP55 homolog) (SKAP-55HOM) (SKAP-HOM) (Src family-associated phosphoprotein 2) (Src kinase-associated phosphoprotein 55-related protein) (Src-associated adapter protein with PH and SH3 domains) May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway. {ECO:0000269|PubMed:12893833, ECO:0000269|PubMed:9837776}.
O94915 FRYL S2340 ochoa Protein furry homolog-like (ALL1-fused gene from chromosome 4p12 protein) Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching (By similarity). May function as a transcriptional activator. {ECO:0000250, ECO:0000269|PubMed:16061630}.
O95049 TJP3 S346 ochoa Tight junction protein ZO-3 (Tight junction protein 3) (Zona occludens protein 3) (Zonula occludens protein 3) TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:16129888). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Binds and recruits PATJ to tight junctions where it connects and stabilizes apical and lateral components of tight junctions (PubMed:16129888). Promotes cell-cycle progression through the sequestration of cyclin D1 (CCND1) at tight junctions during mitosis which prevents CCND1 degradation during M-phase and enables S-phase transition (PubMed:21411630). With TJP1 and TJP2, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). Contrary to TJP2, TJP3 is dispensable for individual viability, embryonic development, epithelial differentiation, and the establishment of TJs, at least in the laboratory environment (By similarity). {ECO:0000250|UniProtKB:O62683, ECO:0000250|UniProtKB:Q9QXY1, ECO:0000269|PubMed:16129888, ECO:0000269|PubMed:21411630}.
O95049 TJP3 S368 ochoa Tight junction protein ZO-3 (Tight junction protein 3) (Zona occludens protein 3) (Zonula occludens protein 3) TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:16129888). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Binds and recruits PATJ to tight junctions where it connects and stabilizes apical and lateral components of tight junctions (PubMed:16129888). Promotes cell-cycle progression through the sequestration of cyclin D1 (CCND1) at tight junctions during mitosis which prevents CCND1 degradation during M-phase and enables S-phase transition (PubMed:21411630). With TJP1 and TJP2, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). Contrary to TJP2, TJP3 is dispensable for individual viability, embryonic development, epithelial differentiation, and the establishment of TJs, at least in the laboratory environment (By similarity). {ECO:0000250|UniProtKB:O62683, ECO:0000250|UniProtKB:Q9QXY1, ECO:0000269|PubMed:16129888, ECO:0000269|PubMed:21411630}.
O95425 SVIL S341 ochoa Supervillin (Archvillin) (p205/p250) [Isoform 1]: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699). Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (PubMed:19109420). {ECO:0000269|PubMed:12711699, ECO:0000269|PubMed:19109420}.; FUNCTION: [Isoform 2]: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity). {ECO:0000250|UniProtKB:O46385}.
O95644 NFATC1 S161 psp Nuclear factor of activated T-cells, cytoplasmic 1 (NF-ATc1) (NFATc1) (NFAT transcription complex cytosolic component) (NF-ATc) (NFATc) Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells (PubMed:10358178). Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function (By similarity). {ECO:0000250|UniProtKB:O88942, ECO:0000269|PubMed:10358178}.
O95696 BRD1 S506 ochoa Bromodomain-containing protein 1 (BR140-like protein) (Bromodomain and PHD finger-containing protein 2) Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, that acts as a regulator of hematopoiesis (PubMed:16387653, PubMed:21753189, PubMed:21880731). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby promoting erythroid differentiation (PubMed:21753189). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:21880731}.
P02671 FGA S364 ochoa|psp Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain] Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}.
P02730 SLC4A1 S357 ochoa Band 3 anion transport protein (Anion exchange protein 1) (AE 1) (Anion exchanger 1) (Solute carrier family 4 member 1) (CD antigen CD233) Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein (PubMed:10926824, PubMed:14734552, PubMed:1538405, PubMed:16227998, PubMed:20151848, PubMed:24121512, PubMed:28387307, PubMed:35835865). Component of the ankyrin-1 complex of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin (PubMed:1538405, PubMed:20151848, PubMed:35835865). Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine (PubMed:10926824, PubMed:14734552, PubMed:16227998, PubMed:24121512, PubMed:28387307). {ECO:0000269|PubMed:10926824, ECO:0000269|PubMed:14734552, ECO:0000269|PubMed:1538405, ECO:0000269|PubMed:16227998, ECO:0000269|PubMed:20151848, ECO:0000269|PubMed:24121512, ECO:0000269|PubMed:28387307, ECO:0000269|PubMed:35835865}.; FUNCTION: (Microbial infection) Acts as a receptor for P.falciparum (isolate 3D7) MSP9 and thus, facilitates merozoite invasion of erythrocytes (PubMed:14630931). Acts as a receptor for P.falciparum (isolate 3D7) MSP1 and thus, facilitates merozoite invasion of erythrocytes (PubMed:12692305). {ECO:0000269|PubMed:12692305, ECO:0000269|PubMed:14630931}.
P04049 RAF1 S267 ochoa RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}.
P04155 TFF1 S49 ochoa Trefoil factor 1 (Breast cancer estrogen-inducible protein) (PNR-2) (Polypeptide P1.A) (hP1.A) (Protein pS2) Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. May inhibit the growth of calcium oxalate crystals in urine. {ECO:0000269|PubMed:16308573}.
P04792 HSPB1 S86 ochoa|psp Heat shock protein beta-1 (HspB1) (28 kDa heat shock protein) (Estrogen-regulated 24 kDa protein) (Heat shock 27 kDa protein) (HSP 27) (Heat shock protein family B member 1) (Stress-responsive protein 27) (SRP27) Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state (PubMed:10383393, PubMed:20178975). Plays a role in stress resistance and actin organization (PubMed:19166925). Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins (PubMed:23728742). {ECO:0000269|PubMed:10383393, ECO:0000269|PubMed:19166925, ECO:0000269|PubMed:20178975, ECO:0000269|PubMed:23728742}.
P08238 HSP90AB1 S594 ochoa Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}.
P08588 ADRB1 S412 psp Beta-1 adrenergic receptor (Beta-1 adrenoreceptor) (Beta-1 adrenoceptor) Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling. Involved in the regulation of sleep/wake behaviors (PubMed:31473062). {ECO:0000269|PubMed:12391161, ECO:0000269|PubMed:31473062}.
P10398 ARAF S222 ochoa Serine/threonine-protein kinase A-Raf (EC 2.7.11.1) (Proto-oncogene A-Raf) (Proto-oncogene A-Raf-1) (Proto-oncogene Pks) Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade. Phosphorylates PFKFB2 (PubMed:36402789). {ECO:0000269|PubMed:22609986, ECO:0000269|PubMed:36402789}.; FUNCTION: [Isoform 2]: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation. {ECO:0000269|PubMed:22609986}.
P10586 PTPRF S1299 ochoa Receptor-type tyrosine-protein phosphatase F (EC 3.1.3.48) (Leukocyte common antigen related) (LAR) Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity.; FUNCTION: The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.
P17302 GJA1 S330 ochoa|psp Gap junction alpha-1 protein (Connexin-43) (Cx43) (Gap junction 43 kDa heart protein) Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles (By similarity). {ECO:0000250|UniProtKB:P08050, ECO:0000250|UniProtKB:P23242}.
P20273 CD22 S725 ochoa B-cell receptor CD22 (B-lymphocyte cell adhesion molecule) (BL-CAM) (Sialic acid-binding Ig-like lectin 2) (Siglec-2) (T-cell surface antigen Leu-14) (CD antigen CD22) Most highly expressed siglec (sialic acid-binding immunoglobulin-like lectin) on B-cells that plays a role in various aspects of B-cell biology including differentiation, antigen presentation, and trafficking to bone marrow (PubMed:34330755, PubMed:8627166). Binds to alpha 2,6-linked sialic acid residues of surface molecules such as CD22 itself, CD45 and IgM in a cis configuration. Can also bind to ligands on other cells as an adhesion molecule in a trans configuration (PubMed:20172905). Acts as an inhibitory coreceptor on the surface of B-cells and inhibits B-cell receptor induced signaling, characterized by inhibition of the calcium mobilization and cellular activation. Mechanistically, the immunoreceptor tyrosine-based inhibitory motif domain is phosphorylated by the Src kinase LYN, which in turn leads to the recruitment of the protein tyrosine phosphatase 1/PTPN6, leading to the negative regulation of BCR signaling (PubMed:8627166). If this negative signaling from is of sufficient strength, apoptosis of the B-cell can be induced (PubMed:20516366). {ECO:0000269|PubMed:20172905, ECO:0000269|PubMed:20516366, ECO:0000269|PubMed:34330755, ECO:0000269|PubMed:8627166}.
P21333 FLNA S2531 ochoa Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}.
P22681 CBL S799 ochoa E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL) E3 ubiquitin-protein ligase that acts as a negative regulator of many signaling pathways by mediating ubiquitination of cell surface receptors (PubMed:10514377, PubMed:11896602, PubMed:14661060, PubMed:14739300, PubMed:15190072, PubMed:17509076, PubMed:18374639, PubMed:19689429, PubMed:21596750, PubMed:28381567). Accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome (PubMed:10514377, PubMed:14661060, PubMed:14739300, PubMed:17094949, PubMed:17509076, PubMed:17974561). Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, CSF1R, EPHA8 and KDR and mediates their ubiquitination to terminate signaling (PubMed:15190072, PubMed:18374639, PubMed:21596750). Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation (PubMed:11896602). Ubiquitinates EGFR and SPRY2 (PubMed:17094949, PubMed:17974561). Ubiquitinates NECTIN1 following association between NECTIN1 and herpes simplex virus 1/HHV-1 envelope glycoprotein D, leading to NECTIN1 removal from cell surface (PubMed:28381567). Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis (PubMed:15190072, PubMed:18374639). Essential for osteoclastic bone resorption (PubMed:14739300). The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:14739300). May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBLB, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity). {ECO:0000250|UniProtKB:P22682, ECO:0000269|PubMed:10514377, ECO:0000269|PubMed:11896602, ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:14739300, ECO:0000269|PubMed:15190072, ECO:0000269|PubMed:17094949, ECO:0000269|PubMed:17509076, ECO:0000269|PubMed:17974561, ECO:0000269|PubMed:18374639, ECO:0000269|PubMed:19689429, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:28381567}.
P23497 SP100 S459 ochoa Nuclear autoantigen Sp-100 (Nuclear dot-associated Sp100 protein) (Speckled 100 kDa) Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation. {ECO:0000269|PubMed:11909962, ECO:0000269|PubMed:14647468, ECO:0000269|PubMed:15247905, ECO:0000269|PubMed:15592518, ECO:0000269|PubMed:15767676, ECO:0000269|PubMed:16177824, ECO:0000269|PubMed:17245429, ECO:0000269|PubMed:21274506, ECO:0000269|PubMed:21880768}.
P23588 EIF4B S430 ochoa Eukaryotic translation initiation factor 4B (eIF-4B) Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.
P28290 ITPRID2 S874 ochoa Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) None
P30086 PEBP1 S60 ochoa Phosphatidylethanolamine-binding protein 1 (PEBP-1) (HCNPpp) (Neuropolypeptide h3) (Prostatic-binding protein) (Raf kinase inhibitor protein) (RKIP) [Cleaved into: Hippocampal cholinergic neurostimulating peptide (HCNP)] Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation. {ECO:0000250, ECO:0000269|PubMed:18294816}.; FUNCTION: HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity). {ECO:0000250}.
P30260 CDC27 S387 ochoa Cell division cycle protein 27 homolog (Anaphase-promoting complex subunit 3) (APC3) (CDC27 homolog) (CDC27Hs) (H-NUC) Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}.
P30405 PPIF S39 ochoa Peptidyl-prolyl cis-trans isomerase F, mitochondrial (PPIase F) (EC 5.2.1.8) (Cyclophilin D) (CyP-D) (CypD) (Cyclophilin F) (Mitochondrial cyclophilin) (CyP-M) (Rotamase F) PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Involved in regulation of the mitochondrial permeability transition pore (mPTP) (PubMed:26387735). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated (PubMed:26387735). In cooperation with mitochondrial p53/TP53 is involved in activating oxidative stress-induced necrosis (PubMed:22726440). Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels (By similarity). Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis (PubMed:19228691). {ECO:0000250|UniProtKB:Q99KR7, ECO:0000269|PubMed:19228691, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22726440, ECO:0000269|PubMed:26387735}.
P35269 GTF2F1 S385 ochoa|psp General transcription factor IIF subunit 1 (General transcription factor IIF 74 kDa subunit) (Transcription initiation factor IIF subunit alpha) (TFIIF-alpha) (Transcription initiation factor RAP74) TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. {ECO:0000269|PubMed:10428810}.
P36915 GNL1 S55 ochoa Guanine nucleotide-binding protein-like 1 (GTP-binding protein HSR1) Possible regulatory or functional link with the histocompatibility cluster.
P40337 VHL S80 ochoa|psp von Hippel-Lindau disease tumor suppressor (Protein G7) (pVHL) Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex (PubMed:10944113, PubMed:17981124, PubMed:19584355). Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions (PubMed:10944113, PubMed:17981124). Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases (PubMed:10944113, PubMed:17981124). Ubiquitinates, in an oxygen-responsive manner, ADRB2 (PubMed:19584355). Acts as a negative regulator of mTORC1 by promoting ubiquitination and degradation of RPTOR (PubMed:34290272). {ECO:0000269|PubMed:10944113, ECO:0000269|PubMed:17981124, ECO:0000269|PubMed:19584355, ECO:0000269|PubMed:34290272}.
P41235 HNF4A S151 psp Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) (TCF-14) (Transcription factor HNF-4) Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes (PubMed:30597922). Activates the transcription of CYP2C38 (By similarity). Represses the CLOCK-BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells (PubMed:30530698). {ECO:0000250|UniProtKB:P49698, ECO:0000269|PubMed:30530698, ECO:0000269|PubMed:30597922}.
P42345 MTOR S2454 ochoa Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin and FKBP12 target 1) (Rapamycin target protein 1) (Tyrosine-protein kinase mTOR) (EC 2.7.10.2) Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals (PubMed:12087098, PubMed:12150925, PubMed:12150926, PubMed:12231510, PubMed:12718876, PubMed:14651849, PubMed:15268862, PubMed:15467718, PubMed:15545625, PubMed:15718470, PubMed:18497260, PubMed:18762023, PubMed:18925875, PubMed:20516213, PubMed:20537536, PubMed:21659604, PubMed:23429703, PubMed:23429704, PubMed:25799227, PubMed:26018084, PubMed:29150432, PubMed:29236692, PubMed:31112131, PubMed:31601708, PubMed:32561715, PubMed:34519269, PubMed:37751742). MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins (PubMed:15268862, PubMed:15467718, PubMed:17517883, PubMed:18372248, PubMed:18497260, PubMed:18925875, PubMed:20516213, PubMed:21576368, PubMed:21659604, PubMed:23429704, PubMed:30171069, PubMed:29236692, PubMed:37751742). Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2) (PubMed:15268862, PubMed:15467718, PubMed:18497260, PubMed:18925875, PubMed:20516213, PubMed:21576368, PubMed:21659604, PubMed:23429704, PubMed:29424687, PubMed:29567957, PubMed:35926713). In response to nutrients, growth factors or amino acids, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis (PubMed:12087098, PubMed:12150925, PubMed:12150926, PubMed:12231510, PubMed:12718876, PubMed:14651849, PubMed:15268862, PubMed:15467718, PubMed:15545625, PubMed:15718470, PubMed:18497260, PubMed:18762023, PubMed:18925875, PubMed:20516213, PubMed:20537536, PubMed:21659604, PubMed:23429703, PubMed:23429704, PubMed:25799227, PubMed:26018084, PubMed:29150432, PubMed:29236692, PubMed:31112131, PubMed:34519269). This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E) (PubMed:24403073, PubMed:29236692). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4 (PubMed:12087098, PubMed:12150925, PubMed:18925875, PubMed:29150432, PubMed:29236692). Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation, through transcriptional enhancement of the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex (PubMed:23429703, PubMed:23429704). Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor (PubMed:20516213). Activates dormant ribosomes by mediating phosphorylation of SERBP1, leading to SERBP1 inactivation and reactivation of translation (PubMed:36691768). In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1 (PubMed:23426360). To maintain energy homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A (By similarity). In the same time, mTORC1 inhibits catabolic pathways: negatively regulates autophagy through phosphorylation of ULK1 (PubMed:32561715). Under nutrient sufficiency, phosphorylates ULK1 at 'Ser-758', disrupting the interaction with AMPK and preventing activation of ULK1 (PubMed:32561715). Also prevents autophagy through phosphorylation of the autophagy inhibitor DAP (PubMed:20537536). Also prevents autophagy by phosphorylating RUBCNL/Pacer under nutrient-rich conditions (PubMed:30704899). Prevents autophagy by mediating phosphorylation of AMBRA1, thereby inhibiting AMBRA1 ability to mediate ubiquitination of ULK1 and interaction between AMBRA1 and PPP2CA (PubMed:23524951, PubMed:25438055). mTORC1 exerts a feedback control on upstream growth factor signaling that includes phosphorylation and activation of GRB10 a INSR-dependent signaling suppressor (PubMed:21659604). Among other potential targets mTORC1 may phosphorylate CLIP1 and regulate microtubules (PubMed:12231510). The mTORC1 complex is inhibited in response to starvation and amino acid depletion (PubMed:12150925, PubMed:12150926, PubMed:24403073, PubMed:31695197). The non-canonical mTORC1 complex, which acts independently of RHEB, specifically mediates phosphorylation of MiT/TFE factors MITF, TFEB and TFE3 in the presence of nutrients, promoting their cytosolic retention and inactivation (PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:24448649, PubMed:32612235, PubMed:36608670, PubMed:36697823). Upon starvation or lysosomal stress, inhibition of mTORC1 induces dephosphorylation and nuclear translocation of TFEB and TFE3, promoting their transcription factor activity (PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:24448649, PubMed:32612235, PubMed:36608670). The mTORC1 complex regulates pyroptosis in macrophages by promoting GSDMD oligomerization (PubMed:34289345). MTOR phosphorylates RPTOR which in turn inhibits mTORC1 (By similarity). As part of the mTORC2 complex, MTOR transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15268862, PubMed:15467718, PubMed:24670654, PubMed:29424687, PubMed:29567957, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:15268862, PubMed:15467718, PubMed:21376236, PubMed:24670654, PubMed:29424687, PubMed:29567957, PubMed:35926713). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:15467718). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:15718470, PubMed:21376236, PubMed:24670654, PubMed:29424687, PubMed:29567957). mTORC2 also regulates the phosphorylation of SGK1 at 'Ser-422' (PubMed:18925875). mTORC2 may regulate the actin cytoskeleton, through phosphorylation of PRKCA, PXN and activation of the Rho-type guanine nucleotide exchange factors RHOA and RAC1A or RAC1B (PubMed:15268862). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). May also regulate insulin signaling by acting as a tyrosine protein kinase that catalyzes phosphorylation of IGF1R and INSR; additional evidence are however required to confirm this result in vivo (PubMed:26584640). Regulates osteoclastogenesis by adjusting the expression of CEBPB isoforms (By similarity). Plays an important regulatory role in the circadian clock function; regulates period length and rhythm amplitude of the suprachiasmatic nucleus (SCN) and liver clocks (By similarity). {ECO:0000250|UniProtKB:Q9JLN9, ECO:0000269|PubMed:12087098, ECO:0000269|PubMed:12150925, ECO:0000269|PubMed:12150926, ECO:0000269|PubMed:12231510, ECO:0000269|PubMed:12718876, ECO:0000269|PubMed:14651849, ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15545625, ECO:0000269|PubMed:15718470, ECO:0000269|PubMed:17517883, ECO:0000269|PubMed:18372248, ECO:0000269|PubMed:18497260, ECO:0000269|PubMed:18762023, ECO:0000269|PubMed:18925875, ECO:0000269|PubMed:20516213, ECO:0000269|PubMed:20537536, ECO:0000269|PubMed:21376236, ECO:0000269|PubMed:21576368, ECO:0000269|PubMed:21659604, ECO:0000269|PubMed:22343943, ECO:0000269|PubMed:22576015, ECO:0000269|PubMed:22692423, ECO:0000269|PubMed:23426360, ECO:0000269|PubMed:23429703, ECO:0000269|PubMed:23429704, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:24403073, ECO:0000269|PubMed:24448649, ECO:0000269|PubMed:24670654, ECO:0000269|PubMed:25438055, ECO:0000269|PubMed:25799227, ECO:0000269|PubMed:26018084, ECO:0000269|PubMed:26584640, ECO:0000269|PubMed:29150432, ECO:0000269|PubMed:29236692, ECO:0000269|PubMed:29424687, ECO:0000269|PubMed:29567957, ECO:0000269|PubMed:30171069, ECO:0000269|PubMed:30704899, ECO:0000269|PubMed:31112131, ECO:0000269|PubMed:31601708, ECO:0000269|PubMed:31695197, ECO:0000269|PubMed:32561715, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:34289345, ECO:0000269|PubMed:34519269, ECO:0000269|PubMed:35926713, ECO:0000269|PubMed:36608670, ECO:0000269|PubMed:36691768, ECO:0000269|PubMed:36697823, ECO:0000269|PubMed:37751742}.
P43243 MATR3 S606 ochoa Matrin-3 May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32245947}.
P46013 MKI67 S411 ochoa Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}.
P48634 PRRC2A S1115 ochoa Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}.
P48681 NES S323 ochoa Nestin Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}.
P48764 SLC9A3 S563 ochoa Sodium/hydrogen exchanger 3 (Na(+)/H(+) exchanger 3) (NHE-3) (Solute carrier family 9 member 3) Plasma membrane Na(+)/H(+) antiporter (PubMed:18829453, PubMed:26358773, PubMed:35613257). Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry, playing a key role in salt and fluid absorption and pH homeostasis (By similarity). Major apical Na(+)/H(+) exchanger in kidney and intestine playing an important role in renal and intestine Na(+) absorption and blood pressure regulation (PubMed:24622516, PubMed:26358773). {ECO:0000250|UniProtKB:G3X939, ECO:0000269|PubMed:18829453, ECO:0000269|PubMed:24622516, ECO:0000269|PubMed:26358773, ECO:0000269|PubMed:35613257}.
P49450 CENPA S27 ochoa Histone H3-like centromeric protein A (Centromere autoantigen A) (Centromere protein A) (CENP-A) Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes (PubMed:11756469, PubMed:14667408, PubMed:15282608, PubMed:15475964, PubMed:15702419, PubMed:17651496, PubMed:19114591, PubMed:20739937, PubMed:27499292, PubMed:7962047, PubMed:9024683). Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore (PubMed:18072184). The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3 (PubMed:26878239, PubMed:27499292). May serve as an epigenetic mark that propagates centromere identity through replication and cell division (PubMed:15282608, PubMed:15475964, PubMed:20739937, PubMed:21478274, PubMed:26878239). Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis (PubMed:11756469, PubMed:14667408, PubMed:18072184, PubMed:23818633, PubMed:25556658, PubMed:27499292). {ECO:0000269|PubMed:11756469, ECO:0000269|PubMed:14667408, ECO:0000269|PubMed:15282608, ECO:0000269|PubMed:15475964, ECO:0000269|PubMed:15702419, ECO:0000269|PubMed:17651496, ECO:0000269|PubMed:18072184, ECO:0000269|PubMed:19114591, ECO:0000269|PubMed:21478274, ECO:0000269|PubMed:23818633, ECO:0000269|PubMed:25556658, ECO:0000269|PubMed:26878239, ECO:0000269|PubMed:27499292, ECO:0000269|PubMed:7962047, ECO:0000269|PubMed:9024683, ECO:0000305|PubMed:20739937}.
P49815 TSC2 S1346 ochoa Tuberin (Tuberous sclerosis 2 protein) Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:33436626, PubMed:35772404). Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12172553, PubMed:12820960, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:33436626). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:35772404). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity). {ECO:0000250|UniProtKB:P49816, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12820960, ECO:0000269|PubMed:12842888, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:22819219, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:33436626, ECO:0000269|PubMed:35772404}.
P50548 ERF S190 ochoa ETS domain-containing transcription factor ERF (Ets2 repressor factor) (PE-2) Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment (By similarity). May be important for regulating trophoblast stem cell differentiation (By similarity). {ECO:0000250}.
P52292 KPNA2 S62 ochoa|psp Importin subunit alpha-1 (Karyopherin subunit alpha-2) (RAG cohort protein 1) (SRP1-alpha) Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1 (PubMed:28991411, PubMed:32130408, PubMed:7604027, PubMed:7754385). Binds specifically and directly to substrates containing either a simple or bipartite NLS motif (PubMed:28991411, PubMed:32130408, PubMed:7604027, PubMed:7754385). Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:7604027, PubMed:7754385). At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediator of PR-DUB complex component BAP1 nuclear import; acts redundantly with KPNA1 and Transportin-1/TNPO1 (PubMed:35446349). {ECO:0000269|PubMed:28991411, ECO:0000269|PubMed:32130408, ECO:0000269|PubMed:35446349, ECO:0000269|PubMed:7604027, ECO:0000269|PubMed:7754385}.
P52597 HNRNPF S203 ochoa Heterogeneous nuclear ribonucleoprotein F (hnRNP F) (Nucleolin-like protein mcs94-1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein F, N-terminally processed] Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state. {ECO:0000269|PubMed:20526337}.
P52799 EFNB2 S268 ochoa Ephrin-B2 (EPH-related receptor tyrosine kinase ligand 5) (LERK-5) (HTK ligand) (HTK-L) Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons. {ECO:0000269|PubMed:12734395}.; FUNCTION: (Microbial infection) Acts as a receptor for Hendra virus and Nipah virus. {ECO:0000269|PubMed:15998730, ECO:0000269|PubMed:16007075, ECO:0000269|PubMed:16477309, ECO:0000269|PubMed:17376907}.
P53602 MVD S104 ochoa Diphosphomevalonate decarboxylase (EC 4.1.1.33) (Mevalonate (diphospho)decarboxylase) (MDDase) (Mevalonate pyrophosphate decarboxylase) Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis. {ECO:0000269|PubMed:18823933, ECO:0000269|PubMed:8626466, ECO:0000269|PubMed:9392419}.
P53814 SMTN S800 ochoa Smoothelin Structural protein of the cytoskeleton.
P54646 PRKAA2 S491 ochoa|psp 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPK subunit alpha-2) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:17307971, PubMed:17712357). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (PubMed:17307971, PubMed:17712357). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (PubMed:17307971, PubMed:17712357). Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively (PubMed:7959015). Promotes lipolysis of lipid droplets by mediating phosphorylation of isoform 1 of CHKA (CHKalpha2) (PubMed:34077757). Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3 (By similarity). Involved in insulin receptor/INSR internalization (PubMed:25687571). AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160 (By similarity). Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A (PubMed:11518699, PubMed:11554766, PubMed:15866171, PubMed:17711846, PubMed:18184930). Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm (By similarity). In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription (By similarity). Acts as a key regulator of cell growth and proliferation by phosphorylating FNIP1, TSC2, RPTOR, WDR24 and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2 (PubMed:14651849, PubMed:20160076, PubMed:21205641). Also phosphorylates and inhibits GATOR2 subunit WDR24 in response to nutrient limitation, leading to suppress glucose-mediated mTORC1 activation (PubMed:36732624). In response to energetic stress, phosphorylates FNIP1, inactivating the non-canonical mTORC1 signaling, thereby promoting nuclear translocation of TFEB and TFE3, and inducing transcription of lysosomal or autophagy genes (PubMed:37079666). In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1 (PubMed:21205641). In that process, it also activates WDR45/WIPI4 (PubMed:28561066). Phosphorylates CASP6, thereby preventing its autoprocessing and subsequent activation (PubMed:32029622). AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it (By similarity). May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it (By similarity). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (PubMed:17486097). Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1 (PubMed:12519745, PubMed:20074060). Plays an important role in the differential regulation of pro-autophagy (composed of PIK3C3, BECN1, PIK3R4 and UVRAG or ATG14) and non-autophagy (composed of PIK3C3, BECN1 and PIK3R4) complexes, in response to glucose starvation (By similarity). Can inhibit the non-autophagy complex by phosphorylating PIK3C3 and can activate the pro-autophagy complex by phosphorylating BECN1 (By similarity). Upon glucose starvation, promotes ARF6 activation in a kinase-independent manner leading to cell migration (PubMed:36017701). Upon glucose deprivation mediates the phosphorylation of ACSS2 at 'Ser-659', which exposes the nuclear localization signal of ACSS2, required for its interaction with KPNA1 and nuclear translocation (PubMed:28552616). Upon stress, regulates mitochondrial fragmentation through phosphorylation of MTFR1L (PubMed:36367943). {ECO:0000250|UniProtKB:Q09137, ECO:0000250|UniProtKB:Q8BRK8, ECO:0000269|PubMed:11518699, ECO:0000269|PubMed:11554766, ECO:0000269|PubMed:12519745, ECO:0000269|PubMed:14651849, ECO:0000269|PubMed:15866171, ECO:0000269|PubMed:17486097, ECO:0000269|PubMed:17711846, ECO:0000269|PubMed:18184930, ECO:0000269|PubMed:20074060, ECO:0000269|PubMed:20160076, ECO:0000269|PubMed:21205641, ECO:0000269|PubMed:25687571, ECO:0000269|PubMed:28552616, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:32029622, ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:36017701, ECO:0000269|PubMed:36367943, ECO:0000269|PubMed:36732624, ECO:0000269|PubMed:37079666, ECO:0000269|PubMed:7959015, ECO:0000303|PubMed:17307971, ECO:0000303|PubMed:17712357}.
P60709 ACTB S265 ochoa Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (PubMed:39321809, PubMed:38609661). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:Q6QAQ1, ECO:0000269|PubMed:25255767, ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}.
P61764 STXBP1 S516 ochoa Syntaxin-binding protein 1 (MUNC18-1) (N-Sec1) (Protein unc-18 homolog 1) (Unc18-1) (Protein unc-18 homolog A) (Unc-18A) (p67) Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins (By similarity). Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. Involved in the release of neurotransmitters from neurons through interacting with SNARE complex component STX1A and mediating the assembly of the SNARE complex at synaptic membranes (By similarity). May play a role in determining the specificity of intracellular fusion reactions. {ECO:0000250|UniProtKB:O08599, ECO:0000250|UniProtKB:P61765}.
P62995 TRA2B S26 ochoa Transformer-2 protein homolog beta (TRA-2 beta) (TRA2-beta) (hTRA2-beta) (Splicing factor, arginine/serine-rich 10) (Transformer-2 protein homolog B) Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:12761049, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:9546399}.
P63261 ACTG1 S265 ochoa Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage (By similarity). {ECO:0000250|UniProtKB:P63260, ECO:0000305|PubMed:29581253}.
P78314 SH3BP2 S435 ochoa SH3 domain-binding protein 2 (3BP-2) Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism.
P98182 ZNF200 S189 ochoa Zinc finger protein 200 Localizes protein arginine N-methyltransferase PRMT3 to the nucleus. {ECO:0000269|PubMed:39513743}.
Q02156 PRKCE S388 ochoa Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon) Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration. In HeLa cells, contributes to hepatocyte growth factor (HGF)-induced cell migration, and in human corneal epithelial cells, plays a critical role in wound healing after activation by HGF. During cytokinesis, forms a complex with YWHAB, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implicate the regulation of RHOA. In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F-actin via interaction with COPB1. During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length. Plays a role in the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3). Involved in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement. May be involved in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation. Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol. Upon PMA treatment, phosphorylates the capsaicin- and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons. Is able to form a complex with PDLIM5 and N-type calcium channel, and may enhance channel activities and potentiates fast synaptic transmission by phosphorylating the pore-forming alpha subunit CACNA1B (CaV2.2). In prostate cancer cells, interacts with and phosphorylates STAT3, which increases DNA-binding and transcriptional activity of STAT3 and seems to be essential for prostate cancer cell invasion. Downstream of TLR4, plays an important role in the lipopolysaccharide (LPS)-induced immune response by phosphorylating and activating TICAM2/TRAM, which in turn activates the transcription factor IRF3 and subsequent cytokines production. In differentiating erythroid progenitors, is regulated by EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2. May be involved in the regulation of the insulin-induced phosphorylation and activation of AKT1. Phosphorylates NLRP5/MATER and may thereby modulate AKT pathway activation in cumulus cells (PubMed:19542546). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000269|PubMed:11884385, ECO:0000269|PubMed:1374067, ECO:0000269|PubMed:15355962, ECO:0000269|PubMed:16757566, ECO:0000269|PubMed:17603037, ECO:0000269|PubMed:17875639, ECO:0000269|PubMed:17875724, ECO:0000269|PubMed:19542546, ECO:0000269|PubMed:21806543, ECO:0000269|PubMed:36040231}.
Q03001 DST S7518 ochoa Dystonin (230 kDa bullous pemphigoid antigen) (230/240 kDa bullous pemphigoid antigen) (Bullous pemphigoid antigen 1) (BPA) (Bullous pemphigoid antigen) (Dystonia musculorum protein) (Hemidesmosomal plaque protein) Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1 (By similarity). {ECO:0000250|UniProtKB:Q91ZU6}.; FUNCTION: [Isoform 3]: Plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity.; FUNCTION: [Isoform 6]: Required for bundling actin filaments around the nucleus. {ECO:0000250, ECO:0000269|PubMed:10428034, ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692}.; FUNCTION: [Isoform 7]: Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport.
Q03164 KMT2A S191 ochoa Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}.
Q04726 TLE3 S205 ochoa Transducin-like enhancer protein 3 (Enhancer of split groucho-like protein 3) (ESG3) Transcriptional corepressor that binds to a number of transcription factors (PubMed:28689657). Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling (PubMed:28689657). The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). {ECO:0000250|UniProtKB:Q04724, ECO:0000269|PubMed:28689657}.
Q04727 TLE4 S210 ochoa Transducin-like enhancer protein 4 (Grg-4) (Groucho-related protein 4) Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity). Involved in transcriptional repression of GNRHR and enhances MSX1-mediated transcriptional repression of CGA/alpha-GSU (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q62441}.
Q05D32 CTDSPL2 S36 ochoa CTD small phosphatase-like protein 2 (CTDSP-like 2) (EC 3.1.3.-) Probable phosphatase. {ECO:0000250}.
Q05D32 CTDSPL2 S112 ochoa CTD small phosphatase-like protein 2 (CTDSP-like 2) (EC 3.1.3.-) Probable phosphatase. {ECO:0000250}.
Q07157 TJP1 S323 ochoa Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}.
Q08357 SLC20A2 S324 ochoa Sodium-dependent phosphate transporter 2 (Gibbon ape leukemia virus receptor 2) (GLVR-2) (Phosphate transporter 2) (PiT-2) (Pit2) (hPit2) (Solute carrier family 20 member 2) Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:12205090, PubMed:15955065, PubMed:16790504, PubMed:17494632, PubMed:22327515, PubMed:28722801, PubMed:30704756). Plays a critical role in the determination of bone quality and strength by providing phosphate for bone mineralization (By similarity). Required to maintain normal cerebrospinal fluid phosphate levels (By similarity). Mediates phosphate-induced calcification of vascular smooth muscle cells (VCMCs) and can functionally compensate for loss of SLC20A1 in VCMCs (By similarity). {ECO:0000250|UniProtKB:Q80UP8, ECO:0000269|PubMed:12205090, ECO:0000269|PubMed:15955065, ECO:0000269|PubMed:16790504, ECO:0000269|PubMed:17494632, ECO:0000269|PubMed:22327515, ECO:0000269|PubMed:28722801, ECO:0000269|PubMed:30704756}.; FUNCTION: (Microbial infection) Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) variants. {ECO:0000269|PubMed:11435563, ECO:0000269|PubMed:12205090, ECO:0000269|PubMed:15955065, ECO:0000269|PubMed:8302848}.
Q08AD1 CAMSAP2 S443 ochoa Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1) Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919, ECO:0000269|PubMed:24908486, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28726242}.
Q09666 AHNAK S5790 ochoa Neuroblast differentiation-associated protein AHNAK (Desmoyokin) May be required for neuronal cell differentiation.
Q12774 ARHGEF5 S662 ochoa Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM) Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity). {ECO:0000250|UniProtKB:E9Q7D5, ECO:0000269|PubMed:14662653, ECO:0000269|PubMed:15601624}.
Q12774 ARHGEF5 S1019 ochoa Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM) Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity). {ECO:0000250|UniProtKB:E9Q7D5, ECO:0000269|PubMed:14662653, ECO:0000269|PubMed:15601624}.
Q12815 TROAP S342 ochoa Tastin (Trophinin-assisting protein) (Trophinin-associated protein) Could be involved with bystin and trophinin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation.
Q12872 SFSWAP S917 ochoa Splicing factor, suppressor of white-apricot homolog (Splicing factor, arginine/serine-rich 8) (Suppressor of white apricot protein homolog) Plays a role as an alternative splicing regulator. Regulate its own expression at the level of RNA processing. Also regulates the splicing of fibronectin and CD45 genes. May act, at least in part, by interaction with other R/S-containing splicing factors. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269|PubMed:8940107}.
Q12986 NFX1 S150 ochoa Transcriptional repressor NF-X1 (EC 2.3.2.-) (Nuclear transcription factor, X box-binding protein 1) Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination. {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:15371341, ECO:0000269|PubMed:17267499}.
Q13480 GAB1 S274 ochoa GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1) Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway (PubMed:29408807). {ECO:0000269|PubMed:29408807}.
Q14004 CDK13 S325 ochoa Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}.
Q14155 ARHGEF7 S161 ochoa Rho guanine nucleotide exchange factor 7 (Beta-Pix) (COOL-1) (PAK-interacting exchange factor beta) (p85) Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons. {ECO:0000250, ECO:0000269|PubMed:18184567, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750}.
Q14289 PTK2B S399 ochoa Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK) Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376'. Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca(2+) levels. May also regulate potassium ion transport by phosphorylation of potassium channel subunits. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN; this requires both SRC and PTK2/PYK2. {ECO:0000269|PubMed:10022920, ECO:0000269|PubMed:12771146, ECO:0000269|PubMed:12893833, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:15050747, ECO:0000269|PubMed:15166227, ECO:0000269|PubMed:17634955, ECO:0000269|PubMed:18086875, ECO:0000269|PubMed:18339875, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:18765415, ECO:0000269|PubMed:19086031, ECO:0000269|PubMed:19207108, ECO:0000269|PubMed:19244237, ECO:0000269|PubMed:19428251, ECO:0000269|PubMed:19648005, ECO:0000269|PubMed:19880522, ECO:0000269|PubMed:20001213, ECO:0000269|PubMed:20381867, ECO:0000269|PubMed:20521079, ECO:0000269|PubMed:21357692, ECO:0000269|PubMed:21533080, ECO:0000269|PubMed:7544443, ECO:0000269|PubMed:8670418, ECO:0000269|PubMed:8849729}.
Q14432 PDE3A S446 ochoa cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A) (cGMP-inhibited cAMP phosphodiesterase) (cGI-PDE) Cyclic nucleotide phosphodiesterase with specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:1315035, PubMed:25961942, PubMed:8155697, PubMed:8695850). Also has activity toward cUMP (PubMed:27975297). Independently of its catalytic activity it is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling (PubMed:31420216, PubMed:34707099). {ECO:0000269|PubMed:1315035, ECO:0000269|PubMed:25961942, ECO:0000269|PubMed:27975297, ECO:0000269|PubMed:31420216, ECO:0000269|PubMed:34707099, ECO:0000269|PubMed:8155697, ECO:0000269|PubMed:8695850}.
Q14573 ITPR3 S1840 ochoa Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3 (IP3 receptor isoform 3) (IP3R-3) (InsP3R3) (Type 3 inositol 1,4,5-trisphosphate receptor) (Type 3 InsP3 receptor) Inositol 1,4,5-trisphosphate-gated calcium channel that, upon 1D-myo-inositol 1,4,5-trisphosphate binding, transports calcium from the endoplasmic reticulum lumen to cytoplasm, thus releasing the intracellular calcium and therefore participates in cellular calcium ion homeostasis (PubMed:32949214, PubMed:37898605, PubMed:8081734, PubMed:8288584). 1D-myo-inositol 1,4,5-trisphosphate binds to the ligand-free channel without altering its global conformation, yielding the low-energy resting state, then progresses through resting-to preactivated transitions to the higher energy preactivated state, which increases affinity for calcium, promoting binding of the low basal cytosolic calcium at the juxtamembrane domain (JD) site, favoring the transition through the ensemble of high-energy intermediate states along the trajectory to the fully-open activated state (PubMed:30013099, PubMed:35301323, PubMed:37898605). Upon opening, releases calcium in the cytosol where it can bind to the low-affinity cytoplasmic domain (CD) site and stabilizes the inhibited state to terminate calcium release (PubMed:30013099, PubMed:35301323, PubMed:37898605). {ECO:0000269|PubMed:30013099, ECO:0000269|PubMed:32949214, ECO:0000269|PubMed:35301323, ECO:0000269|PubMed:37898605, ECO:0000269|PubMed:8081734, ECO:0000269|PubMed:8288584}.
Q14678 KANK1 S194 ochoa KN motif and ankyrin repeat domain-containing protein 1 (Ankyrin repeat domain-containing protein 15) (Kidney ankyrin repeat-containing protein) Adapter protein that links structural and signaling protein complexes positioned to guide microtubule and actin cytoskeleton dynamics during cell morphogenesis (PubMed:22084092, PubMed:24120883). At focal adhesions (FAs) rims, organizes cortical microtubule stabilizing complexes (CMSCs) and directly interacts with major FA component TLN1, forming macromolecular assemblies positioned to control microtubule-actin crosstalk at the cell edge (PubMed:24120883, PubMed:27410476). Recruits KIF21A in CMSCs at axonal growth cones and regulates axon guidance by suppressing microtubule growth without inducing microtubule disassembly once it reaches the cell cortex (PubMed:24120883). Interacts with ARFGEF1 and participates in establishing microtubule-organizing center (MTOC) orientation and directed cell movement in wound healing (PubMed:22084092). Regulates actin stress fiber formation and cell migration by inhibiting RHOA activation in response to growth factors; this function involves phosphorylation through PI3K/Akt signaling and may depend on the competitive interaction with 14-3-3 adapter proteins to sequester them from active complexes (PubMed:18458160, PubMed:25961457). Inhibits the formation of lamellipodia but not of filopodia; this function may depend on the competitive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading; this function is partially mediated by BAIAP2 (PubMed:19171758). In the nucleus, is involved in beta-catenin-dependent activation of transcription (PubMed:16968744). During cell division, may regulate DAAM1-dependent RHOA activation that signals centrosome maturation and chromosomal segregation. May also be involved in contractile ring formation during cytokinesis (By similarity). Potential tumor suppressor for renal cell carcinoma (Probable). {ECO:0000250|UniProtKB:E9Q238, ECO:0000269|PubMed:16968744, ECO:0000269|PubMed:18458160, ECO:0000269|PubMed:19171758, ECO:0000269|PubMed:22084092, ECO:0000269|PubMed:24120883, ECO:0000269|PubMed:25961457, ECO:0000269|PubMed:27410476, ECO:0000305|PubMed:12133830}.
Q14934 NFATC4 S281 ochoa|psp Nuclear factor of activated T-cells, cytoplasmic 4 (NF-ATc4) (NFATc4) (T-cell transcription factor NFAT3) (NF-AT3) Ca(2+)-regulated transcription factor that is involved in several processes, including the development and function of the immune, cardiovascular, musculoskeletal, and nervous systems (PubMed:11514544, PubMed:11997522, PubMed:17213202, PubMed:17875713, PubMed:18668201, PubMed:25663301, PubMed:7749981). Involved in T-cell activation, stimulating the transcription of cytokine genes, including that of IL2 and IL4 (PubMed:18347059, PubMed:18668201, PubMed:7749981). Along with NFATC3, involved in embryonic heart development. Following JAK/STAT signaling activation and as part of a complex with NFATC3 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). Involved in mitochondrial energy metabolism required for cardiac morphogenesis and function (By similarity). Transactivates many genes involved in the cardiovascular system, including AGTR2, NPPB/BNP (in synergy with GATA4), NPPA/ANP/ANF and MYH7/beta-MHC (By similarity). Involved in the regulation of adult hippocampal neurogenesis. Involved in BDNF-driven pro-survival signaling in hippocampal adult-born neurons. Involved in the formation of long-term spatial memory and long-term potentiation (By similarity). In cochlear nucleus neurons, may play a role in deafferentation-induced apoptosis during the developmental critical period, when auditory neurons depend on afferent input for survival (By similarity). Binds to and activates the BACE1/Beta-secretase 1 promoter, hence may regulate the proteolytic processing of the amyloid precursor protein (APP) (PubMed:25663301). Plays a role in adipocyte differentiation (PubMed:11997522). May be involved in myoblast differentiation into myotubes (PubMed:17213202). Binds the consensus DNA sequence 5'-GGAAAAT-3' (Probable). In the presence of CREBBP, activates TNF transcription (PubMed:11514544). Binds to PPARG gene promoter and regulates its activity (PubMed:11997522). Binds to PPARG and REG3G gene promoters (By similarity). {ECO:0000250|UniProtKB:D3Z9H7, ECO:0000250|UniProtKB:Q8K120, ECO:0000269|PubMed:11514544, ECO:0000269|PubMed:11997522, ECO:0000269|PubMed:17213202, ECO:0000269|PubMed:17875713, ECO:0000269|PubMed:18347059, ECO:0000269|PubMed:18668201, ECO:0000269|PubMed:25663301, ECO:0000269|PubMed:7749981, ECO:0000305}.
Q15642 TRIP10 S304 ochoa Cdc42-interacting protein 4 (Protein Felic) (Salt tolerant protein) (hSTP) (Thyroid receptor-interacting protein 10) (TR-interacting protein 10) (TRIP-10) Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL. {ECO:0000250, ECO:0000269|PubMed:11069762, ECO:0000269|PubMed:16318909, ECO:0000269|PubMed:16326391}.
Q16513 PKN2 S591 ochoa Serine/threonine-protein kinase N2 (EC 2.7.11.13) (PKN gamma) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2) PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Involved in the negative regulation of ciliogenesis (PubMed:27104747). {ECO:0000269|PubMed:10226025, ECO:0000269|PubMed:10926925, ECO:0000269|PubMed:11777936, ECO:0000269|PubMed:11781095, ECO:0000269|PubMed:15123640, ECO:0000269|PubMed:15364941, ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:20188095, ECO:0000269|PubMed:20974804, ECO:0000269|PubMed:21754995, ECO:0000269|PubMed:27104747, ECO:0000269|PubMed:9121475}.; FUNCTION: (Microbial infection) Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication. {ECO:0000269|PubMed:15364941}.
Q16625 OCLN S378 ochoa Occludin May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions. {ECO:0000269|PubMed:19114660}.; FUNCTION: (Microbial infection) Acts as a coreceptor for hepatitis C virus (HCV) in hepatocytes. {ECO:0000269|PubMed:19182773, ECO:0000269|PubMed:20375010}.
Q16828 DUSP6 S182 ochoa Dual specificity protein phosphatase 6 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase PYST1) (Mitogen-activated protein kinase phosphatase 3) (MAP kinase phosphatase 3) (MKP-3) Dual specificity protein phosphatase, which mediates dephosphorylation and inactivation of MAP kinases (PubMed:8670865). Has a specificity for the ERK family (PubMed:8670865). Plays an important role in alleviating chronic postoperative pain (By similarity). Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity). Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (By similarity). Promotes cell differentiation by regulating MAPK1/MAPK3 activity and regulating the expression of AP1 transcription factors (PubMed:29043977). {ECO:0000250|UniProtKB:Q9DBB1, ECO:0000269|PubMed:29043977, ECO:0000269|PubMed:8670865}.
Q16849 PTPRN S303 ochoa Receptor-type tyrosine-protein phosphatase-like N (R-PTP-N) (Islet cell antigen 512) (ICA 512) (Islet cell autoantigen 3) (PTP IA-2) [Cleaved into: ICA512-N-terminal fragment (ICA512-NTF); ICA512-transmembrane fragment (ICA512-TMF); ICA512-cleaved cytosolic fragment (ICA512-CCF)] Plays a role in vesicle-mediated secretory processes (PubMed:24843546). Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets (By similarity). Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation (PubMed:24843546). Plays a role in insulin secretion in response to glucose stimuli (PubMed:24843546). Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain (By similarity). In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (By similarity). Required to maintain normal levels of renin expression and renin release (By similarity). Seems to lack intrinsic enzyme activity (By similarity). May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (By similarity). {ECO:0000250|UniProtKB:Q60673, ECO:0000269|PubMed:24843546}.; FUNCTION: [ICA512-transmembrane fragment]: ICA512-TMF regulates dynamics and exocytosis of insulin secretory granules (SGs); binding of ICA512-TMF to SNTB2/beta-2-syntrophin is proposed to restrain SGs mobility and exocytosis by tethering them to the actin cytoskeleton depending on UTRN; the function is inhibited by cytoplasmic ICA512-CFF dimerizing with ICA512-TMF and displacing SNTB2. {ECO:0000269|PubMed:18824546, ECO:0000269|PubMed:20886068}.; FUNCTION: [ICA512-cleaved cytosolic fragment]: ICA512-CCF translocated to the nucleus promotes expression of insulin and other granule-related genes; the function implicates binding to and regulating activity of STAT5B probably by preventing its dephosphorylation and potentially by inducing its sumoylation by recruiting PIAS4 (PubMed:15596545, PubMed:16622421, PubMed:18178618). Enhances pancreatic beta-cell proliferation by converging with signaling by STAT5B and STAT3 (PubMed:15596545, PubMed:16622421, PubMed:18178618). ICA512-CCF located in the cytoplasm regulates dynamics and exocytosis of insulin secretory granules (SGs) by dimerizing with ICA512-TMF and displacing SNTB2 thus enhancing SGs mobility and exocytosis (PubMed:18824546, PubMed:20886068). {ECO:0000269|PubMed:15596545, ECO:0000269|PubMed:16622421, ECO:0000269|PubMed:18178618, ECO:0000269|PubMed:18824546, ECO:0000269|PubMed:20886068}.
Q2M3G4 SHROOM1 S314 ochoa Protein Shroom1 (Apical protein 2) May be involved in the assembly of microtubule arrays during cell elongation. {ECO:0000250}.
Q2NKX8 ERCC6L S1036 ochoa DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15) DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase (PubMed:17218258, PubMed:23973328). Functions as ATP-dependent DNA translocase (PubMed:23973328, PubMed:28977671). Can promote Holliday junction branch migration (in vitro) (PubMed:23973328). {ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:23973328, ECO:0000269|PubMed:28977671}.
Q3V6T2 CCDC88A S1425 ochoa Girdin (Akt phosphorylation enhancer) (APE) (Coiled-coil domain-containing protein 88A) (G alpha-interacting vesicle-associated protein) (GIV) (Girders of actin filament) (Hook-related protein 1) (HkRP1) Bifunctional modulator of guanine nucleotide-binding proteins (G proteins) (PubMed:19211784, PubMed:27621449). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein G(i) alpha subunits (PubMed:19211784, PubMed:21954290, PubMed:23509302, PubMed:25187647). Also acts as a guanine nucleotide dissociation inhibitor for guanine nucleotide-binding protein G(s) subunit alpha GNAS (PubMed:27621449). Essential for cell migration (PubMed:16139227, PubMed:19211784, PubMed:20462955, PubMed:21954290). Interacts in complex with G(i) alpha subunits with the EGFR receptor, retaining EGFR at the cell membrane following ligand stimulation and promoting EGFR signaling which triggers cell migration (PubMed:20462955). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex which enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB (PubMed:19211784). Phosphorylation of AKT1/PKB induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Binds in its tyrosine-phosphorylated form to the phosphatidylinositol 3-kinase (PI3K) regulatory subunit PIK3R1 which enables recruitment of PIK3R1 to the EGFR receptor, enhancing PI3K activity and cell migration (PubMed:21954290). Plays a role as a key modulator of the AKT-mTOR signaling pathway, controlling the tempo of the process of newborn neuron integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Inhibition of G(s) subunit alpha GNAS leads to reduced cellular levels of cAMP and suppression of cell proliferation (PubMed:27621449). Essential for the integrity of the actin cytoskeleton (PubMed:16139227, PubMed:19211784). Required for formation of actin stress fibers and lamellipodia (PubMed:15882442). May be involved in membrane sorting in the early endosome (PubMed:15882442). Plays a role in ciliogenesis and cilium morphology and positioning and this may partly be through regulation of the localization of scaffolding protein CROCC/Rootletin (PubMed:27623382). {ECO:0000250|UniProtKB:Q5SNZ0, ECO:0000269|PubMed:15882442, ECO:0000269|PubMed:16139227, ECO:0000269|PubMed:19211784, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:21954290, ECO:0000269|PubMed:23509302, ECO:0000269|PubMed:25187647, ECO:0000269|PubMed:27621449, ECO:0000269|PubMed:27623382}.
Q5KSL6 DGKK S828 ochoa Diacylglycerol kinase kappa (DAG kinase kappa) (DGK-kappa) (EC 2.7.1.107) (142 kDa diacylglycerol kinase) (Diglyceride kinase kappa) Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:16210324, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). {ECO:0000269|PubMed:16210324, ECO:0000269|PubMed:23949095, ECO:0000305}.
Q5SW79 CEP170 S1278 ochoa Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}.
Q5T1M5 FKBP15 S964 ochoa FK506-binding protein 15 (FKBP-15) (133 kDa FK506-binding protein) (133 kDa FKBP) (FKBP-133) (WASP- and FKBP-like protein) (WAFL) May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement. {ECO:0000250, ECO:0000269|PubMed:19121306}.
Q5T200 ZC3H13 S853 ochoa Zinc finger CCCH domain-containing protein 13 Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}.
Q5T5C0 STXBP5 S700 ochoa Syntaxin-binding protein 5 (Lethal(2) giant larvae protein homolog 3) (Tomosyn-1) Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane. Competes with STXBP1 for STX1 binding (By similarity). {ECO:0000250}.
Q5T5C0 STXBP5 S790 ochoa Syntaxin-binding protein 5 (Lethal(2) giant larvae protein homolog 3) (Tomosyn-1) Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane. Competes with STXBP1 for STX1 binding (By similarity). {ECO:0000250}.
Q5T5P2 KIAA1217 S361 ochoa Sickle tail protein homolog Required for normal development of intervertebral disks. {ECO:0000250|UniProtKB:A2AQ25}.
Q5U5Q3 MEX3C S545 ochoa RNA-binding E3 ubiquitin-protein ligase MEX3C (EC 2.3.2.27) (RING finger and KH domain-containing protein 2) (RING finger protein 194) (RING-type E3 ubiquitin transferase MEX3C) E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation. {ECO:0000269|PubMed:22863774, ECO:0000269|PubMed:23446422}.
Q5VT25 CDC42BPA S1616 ochoa Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha) Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration (PubMed:15723050, PubMed:9092543, PubMed:9418861). Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates: PPP1R12A, LIMK1 and LIMK2 (PubMed:11340065, PubMed:11399775). May play a role in TFRC-mediated iron uptake (PubMed:20188707). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). Triggers the formation of an extrusion apical actin ring required for epithelial extrusion of apoptotic cells (PubMed:29162624). {ECO:0000250|UniProtKB:Q3UU96, ECO:0000269|PubMed:11340065, ECO:0000269|PubMed:11399775, ECO:0000269|PubMed:15723050, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:20188707, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:29162624, ECO:0000269|PubMed:9092543, ECO:0000269|PubMed:9418861}.
Q5VTR2 RNF20 S525 ochoa E3 ubiquitin-protein ligase BRE1A (BRE1-A) (hBRE1) (EC 2.3.2.27) (RING finger protein 20) (RING-type E3 ubiquitin transferase BRE1A) Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role inb histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of isoform 2 of PA2G4 in cancer cells leading to its proteasome-mediated degradation. {ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:16337599, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19410543}.; FUNCTION: (Microbial infection) Promotes the human herpesvirus 8 (KSHV) lytic cycle by inducing the expression of lytic viral genes including the latency switch gene RTA/ORF50. {ECO:0000269|PubMed:37888983}.
Q69YQ0 SPECC1L S392 ochoa Cytospin-A (Renal carcinoma antigen NY-REN-22) (Sperm antigen with calponin homology and coiled-coil domains 1-like) (SPECC1-like protein) Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration. {ECO:0000269|PubMed:21703590}.
Q6BDS2 BLTP3A S1111 ochoa Bridge-like lipid transfer protein family member 3A (ICBP90-binding protein 1) (UHRF1-binding protein 1) (Ubiquitin-like containing PHD and RING finger domains 1-binding protein 1) Tube-forming lipid transport protein which probably mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567). May be involved in the retrograde traffic of vesicle clusters in the endocytic pathway to the Golgi complex (PubMed:35499567). {ECO:0000269|PubMed:35499567}.
Q6NYC8 PPP1R18 S133 ochoa Phostensin (Protein phosphatase 1 F-actin cytoskeleton-targeting subunit) (Protein phosphatase 1 regulatory subunit 18) [Isoform 1]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:24434620}.; FUNCTION: [Isoform 4]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:17374523}.
Q6NYC8 PPP1R18 S163 ochoa Phostensin (Protein phosphatase 1 F-actin cytoskeleton-targeting subunit) (Protein phosphatase 1 regulatory subunit 18) [Isoform 1]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:24434620}.; FUNCTION: [Isoform 4]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:17374523}.
Q6P0Q8 MAST2 S1264 ochoa Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1) Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}.
Q6PL18 ATAD2 S170 ochoa ATPase family AAA domain-containing protein 2 (EC 3.6.1.-) (AAA nuclear coregulator cancer-associated protein) (ANCCA) May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells. {ECO:0000269|PubMed:17998543}.
Q6T4R5 NHS S479 ochoa Actin remodeling regulator NHS (Congenital cataracts and dental anomalies protein) (Nance-Horan syndrome protein) May function in cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipod formation. Involved in the regulation eye, tooth, brain and craniofacial development. {ECO:0000269|PubMed:20332100}.
Q6UN15 FIP1L1 S500 ochoa Pre-mRNA 3'-end-processing factor FIP1 (hFip1) (FIP1-like 1 protein) (Factor interacting with PAP) (Rearranged in hypereosinophilia) Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex. {ECO:0000269|PubMed:14749727}.
Q6ZRV2 FAM83H S1106 ochoa Protein FAM83H May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:18252228, ECO:0000269|PubMed:23902688}.
Q6ZV73 FGD6 S1301 ochoa FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24) May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity). {ECO:0000250}.
Q70CQ4 USP31 S887 ochoa Ubiquitin carboxyl-terminal hydrolase 31 (EC 3.4.19.12) (Deubiquitinating enzyme 31) (Ubiquitin thioesterase 31) (Ubiquitin-specific-processing protease 31) Deubiquitinase that recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. May play a role in the regulation of NF-kappa-B signaling pathway by deubiquitinating TRAF2. {ECO:0000269|PubMed:34184746}.; FUNCTION: (Microbial infection) Plays a positive role in foot-and-mouth disease and classical swine fever viral infection. Mechanistically, associates with internal ribosomal entry site (IRES) element within the 5'-untranslated region of viral genomes to promote translation of the virus-encoded polyprotein. {ECO:0000269|PubMed:35468926}.
Q7L2J0 MEPCE S183 ochoa 7SK snRNA methylphosphate capping enzyme (MePCE) (EC 2.1.1.-) (Bicoid-interacting protein 3 homolog) (Bin3 homolog) S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA), leading to stabilize it (PubMed:17643375, PubMed:19906723, PubMed:30559425). Also has a non-enzymatic function as part of the 7SK RNP complex: the 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:17643375). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate the assembly of 7SK RNP complex (PubMed:19906723, PubMed:38100593). MEPCE has a non-enzymatic function in the 7SK RNP complex; interaction with LARP7 within the 7SK RNP complex occluding its catalytic center (PubMed:19906723). Also required for stability of U6 snRNAs (PubMed:38100593). {ECO:0000269|PubMed:17643375, ECO:0000269|PubMed:19906723, ECO:0000269|PubMed:28254838, ECO:0000269|PubMed:30559425, ECO:0000269|PubMed:38100593}.
Q7Z2W4 ZC3HAV1 S257 ochoa Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP) Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). {ECO:0000269|PubMed:18225958, ECO:0000269|PubMed:21102435, ECO:0000269|PubMed:21876179, ECO:0000269|PubMed:22720057}.
Q7Z309 PABIR2 S33 ochoa PABIR family member 2 None
Q7Z309 PABIR2 S58 ochoa PABIR family member 2 None
Q7Z3G6 PRICKLE2 S731 ochoa Prickle-like protein 2 None
Q7Z460 CLASP1 S655 ochoa CLIP-associating protein 1 (Cytoplasmic linker-associated protein 1) (Multiple asters homolog 1) (Protein Orbit homolog 1) (hOrbit1) Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:12837247, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864}.
Q7Z628 NET1 T29 ochoa Neuroepithelial cell-transforming gene 1 protein (Proto-oncogene p65 Net1) (Rho guanine nucleotide exchange factor 8) Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. {ECO:0000269|PubMed:21373644}.
Q7Z6E9 RBBP6 S780 ochoa E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis) E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). {ECO:0000250|UniProtKB:P97868, ECO:0000269|PubMed:18851979, ECO:0000269|PubMed:24726359}.; FUNCTION: (Microbial infection) [Isoform 1]: Restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription. {ECO:0000269|PubMed:30550789}.
Q7Z6Z7 HUWE1 S3116 ochoa E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}.
Q7Z6Z7 HUWE1 S3760 ochoa E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}.
Q86SQ0 PHLDB2 S521 ochoa Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}.
Q86X29 LSR S540 ochoa Lipolysis-stimulated lipoprotein receptor (Angulin-1) Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity). Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (By similarity). {ECO:0000250|UniProtKB:Q99KG5, ECO:0000250|UniProtKB:Q9WU74}.
Q86XN8 MEX3D S514 ochoa RNA-binding protein MEX3D (RING finger and KH domain-containing protein 1) (RING finger protein 193) (TINO) RNA binding protein, may be involved in post-transcriptional regulatory mechanisms. {ECO:0000250}.
Q86XZ4 SPATS2 S394 ochoa Spermatogenesis-associated serine-rich protein 2 (Serine-rich spermatocytes and round spermatid 59 kDa protein) (p59scr) None
Q8IU81 IRF2BP1 S125 ochoa Interferon regulatory factor 2-binding protein 1 (IRF-2-binding protein 1) (IRF-2BP1) (Probable E3 ubiquitin-protein ligase IRF2BP1) (EC 2.3.2.27) (Probable RING-type E3 ubiquitin transferase IRF2BP1) Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. Represses ATF2-dependent transcriptional activation. {ECO:0000269|PubMed:12799427, ECO:0000269|PubMed:18671972}.
Q8IVH2 FOXP4 S451 ochoa Forkhead box protein P4 (Fork head-related protein-like A) Transcriptional repressor that represses lung-specific expression. {ECO:0000250}.
Q8IVT2 MISP S479 ochoa Mitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein) Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus. {ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:23574715}.
Q8IWB9 TEX2 S222 ochoa Testis-expressed protein 2 (Transmembrane protein 96) During endoplasmic reticulum (ER) stress or when cellular ceramide levels increase, may induce contacts between the ER and medial-Golgi complex to facilitate non-vesicular transport of ceramides from the ER to the Golgi complex where they are converted to complex sphingolipids, preventing toxic ceramide accumulation. {ECO:0000269|PubMed:28011845}.
Q8IWU5 SULF2 S838 ochoa Extracellular sulfatase Sulf-2 (hSulf-2) (Arylsulfatase) (EC 3.1.6.1) (N-acetylglucosamine-6-sulfatase) (EC 3.1.6.14) [Cleaved into: Extracellular sulfatase Sulf-2 secreted form] Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity (PubMed:12368295, PubMed:30788513, PubMed:35294879). It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin (PubMed:12368295, PubMed:30788513, PubMed:35294879). {ECO:0000269|PubMed:12368295, ECO:0000269|PubMed:30788513, ECO:0000269|PubMed:35294879}.
Q8IWX8 CHERP S823 ochoa Calcium homeostasis endoplasmic reticulum protein (ERPROT 213-21) (SR-related CTD-associated factor 6) Involved in calcium homeostasis, growth and proliferation. {ECO:0000269|PubMed:10794731, ECO:0000269|PubMed:12656674}.
Q8IZ21 PHACTR4 S451 ochoa Phosphatase and actin regulator 4 Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity). {ECO:0000250}.
Q8IZD4 DCP1B S283 ochoa mRNA-decapping enzyme 1B (EC 3.6.1.62) May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (By similarity). {ECO:0000250|UniProtKB:Q9NPI6}.
Q8N0Z3 SPICE1 S819 ochoa Spindle and centriole-associated protein 1 (Coiled-coil domain-containing protein 52) (Spindle and centriole-associated protein) Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome congression in mitosis. {ECO:0000269|PubMed:20736305}.
Q8N108 MIER1 S491 ochoa Mesoderm induction early response protein 1 (Early response 1) (Er1) (Mi-er1) (hMi-er1) Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing. {ECO:0000269|PubMed:12482978}.
Q8N3F8 MICALL1 Y203 ochoa MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13) Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q8BGT6, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:21795389, ECO:0000269|PubMed:23596323, ECO:0000269|PubMed:31615969, ECO:0000269|PubMed:34100897}.
Q8N5S9 CAMKK1 S82 ochoa Calcium/calmodulin-dependent protein kinase kinase 1 (CaM-KK 1) (CaM-kinase kinase 1) (CaMKK 1) (EC 2.7.11.17) (CaM-kinase IV kinase) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-KK alpha) (CaM-kinase kinase alpha) (CaMKK alpha) Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. {ECO:0000269|PubMed:12935886}.
Q8N6F7 GCSAM S129 ochoa Germinal center-associated signaling and motility protein (Germinal center B-cell-expressed transcript 2 protein) (Germinal center-associated lymphoma protein) (hGAL) Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation. {ECO:0000269|PubMed:17823310, ECO:0000269|PubMed:20844236, ECO:0000269|PubMed:23299888}.
Q8ND24 RNF214 S176 ochoa RING finger protein 214 None
Q8ND76 CCNY S33 ochoa Cyclin-Y (Cyc-Y) (Cyclin box protein 1) (Cyclin fold protein 1) (cyclin-X) Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription. {ECO:0000269|PubMed:18060517, ECO:0000269|PubMed:19524571, ECO:0000269|PubMed:20059949, ECO:0000269|PubMed:22184064}.
Q8NEV8 EXPH5 S393 ochoa Exophilin-5 (Synaptotagmin-like protein homolog lacking C2 domains b) (SlaC2-b) (Slp homolog lacking C2 domains b) May act as Rab effector protein and play a role in vesicle trafficking.
Q8NEY1 NAV1 S460 ochoa Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) May be involved in neuronal migration. {ECO:0000250}.
Q8NF91 SYNE1 S5891 ochoa Nesprin-1 (Enaptin) (KASH domain-containing protein 1) (KASH1) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenesis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette. {ECO:0000250|UniProtKB:Q6ZWR6, ECO:0000269|PubMed:11792814, ECO:0000269|PubMed:18396275}.
Q8NF91 SYNE1 S8280 ochoa Nesprin-1 (Enaptin) (KASH domain-containing protein 1) (KASH1) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenesis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette. {ECO:0000250|UniProtKB:Q6ZWR6, ECO:0000269|PubMed:11792814, ECO:0000269|PubMed:18396275}.
Q8NFW9 MYRIP S542 ochoa Rab effector MyRIP (Exophilin-8) (Myosin-VIIa- and Rab-interacting protein) (Synaptotagmin-like protein lacking C2 domains C) (SlaC2-c) (Slp homolog lacking C2 domains c) Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments. Functions as a protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release (By similarity). {ECO:0000250}.
Q8TEV9 SMCR8 S521 ochoa Guanine nucleotide exchange protein SMCR8 (Smith-Magenis syndrome chromosomal region candidate gene 8 protein) Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:20562859, PubMed:27103069, PubMed:27193190, PubMed:27559131, PubMed:27617292, PubMed:28195531, PubMed:32303654). In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:20562859, PubMed:27103069, PubMed:27617292, PubMed:28195531). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity (PubMed:27617292, PubMed:28195531). As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro (PubMed:32303654). Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates (PubMed:27559131, PubMed:28195531). In addition to its activity in the cytoplasm within the C9orf72-SMCR8 complex, SMCR8 also localizes in the nucleus, where it associates with chromatin and negatively regulates expression of suppresses ULK1 and WIPI2 genes (PubMed:28195531). {ECO:0000269|PubMed:20562859, ECO:0000269|PubMed:27103069, ECO:0000269|PubMed:27193190, ECO:0000269|PubMed:27559131, ECO:0000269|PubMed:27617292, ECO:0000269|PubMed:28195531, ECO:0000269|PubMed:32303654}.
Q8WYP5 AHCTF1 S1952 ochoa Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}.
Q92502 STARD8 S506 ochoa StAR-related lipid transfer protein 8 (Deleted in liver cancer 3 protein) (DLC-3) (START domain-containing protein 8) (StARD8) (START-GAP3) Accelerates GTPase activity of RHOA and CDC42, but not RAC1. Stimulates the hydrolysis of phosphatidylinositol 4,5-bisphosphate by PLCD1. {ECO:0000269|PubMed:17976533}.
Q92738 USP6NL S765 ochoa USP6 N-terminal-like protein (Related to the N-terminus of tre) (RN-tre) Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex. {ECO:0000269|PubMed:11099046, ECO:0000269|PubMed:17562788, ECO:0000269|PubMed:17684057}.
Q92766 RREB1 S1175 ochoa Ras-responsive element-binding protein 1 (RREB-1) (Finger protein in nuclear bodies) (Raf-responsive zinc finger protein LZ321) (Zinc finger motif enhancer-binding protein 1) (Zep-1) Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters (PubMed:10390538, PubMed:15067362, PubMed:17550981, PubMed:8816445, PubMed:9305772). Represses the angiotensinogen gene (PubMed:15067362). Negatively regulates the transcriptional activity of AR (PubMed:17550981). Potentiates the transcriptional activity of NEUROD1 (PubMed:12482979). Promotes brown adipocyte differentiation (By similarity). May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression (PubMed:8816445). {ECO:0000250|UniProtKB:Q3UH06, ECO:0000269|PubMed:10390538, ECO:0000269|PubMed:12482979, ECO:0000269|PubMed:15067362, ECO:0000269|PubMed:17550981, ECO:0000269|PubMed:8816445, ECO:0000269|PubMed:9305772}.
Q92859 NEO1 S803 ochoa Neogenin (Immunoglobulin superfamily DCC subclass member 2) Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response. {ECO:0000269|PubMed:21149453}.
Q96A32 MYL11 S20 ochoa Myosin regulatory light chain 11 (Fast skeletal myosin light chain 2) (MLC2B) (Myosin light chain 11) (Myosin regulatory light chain 2, skeletal muscle isoform) Myosin regulatory subunit that plays an essential role to maintain muscle integrity during early development (By similarity). Plays a role in muscle contraction (By similarity). {ECO:0000250|UniProtKB:O93409}.
Q96E09 PABIR1 S45 ochoa PPP2R1A-PPP2R2A-interacting phosphatase regulator 1 (PABIR family member 1) Acts as an inhibitor of serine/threonine-protein phosphatase 2A (PP2A) activity (PubMed:27588481, PubMed:33108758, PubMed:38123684). Inhibits PP2A activity by blocking the substrate binding site on PPP2R2A and the active site of PPP2CA (PubMed:38123684). Potentiates ubiquitin-mediated proteasomal degradation of serine/threonine-protein phosphatase 2A catalytic subunit alpha (PPP2CA) (PubMed:27588481). Inhibits PP2A-mediated dephosphorylation of WEE1, promoting ubiquitin-mediated proteolysis of WEE1, thereby releasing G2/M checkpoint (PubMed:33108758). {ECO:0000269|PubMed:27588481, ECO:0000269|PubMed:33108758, ECO:0000269|PubMed:38123684}.
Q96E09 PABIR1 S197 ochoa PPP2R1A-PPP2R2A-interacting phosphatase regulator 1 (PABIR family member 1) Acts as an inhibitor of serine/threonine-protein phosphatase 2A (PP2A) activity (PubMed:27588481, PubMed:33108758, PubMed:38123684). Inhibits PP2A activity by blocking the substrate binding site on PPP2R2A and the active site of PPP2CA (PubMed:38123684). Potentiates ubiquitin-mediated proteasomal degradation of serine/threonine-protein phosphatase 2A catalytic subunit alpha (PPP2CA) (PubMed:27588481). Inhibits PP2A-mediated dephosphorylation of WEE1, promoting ubiquitin-mediated proteolysis of WEE1, thereby releasing G2/M checkpoint (PubMed:33108758). {ECO:0000269|PubMed:27588481, ECO:0000269|PubMed:33108758, ECO:0000269|PubMed:38123684}.
Q96HA1 POM121 Y401 ochoa Nuclear envelope pore membrane protein POM 121 (Nuclear envelope pore membrane protein POM 121A) (Nucleoporin Nup121) (Pore membrane protein of 121 kDa) Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}.
Q96MG2 JSRP1 S51 ochoa Junctional sarcoplasmic reticulum protein 1 (Junctional-face membrane protein of 45 kDa homolog) (JP-45) Involved in skeletal muscle excitation/contraction coupling (EC), probably acting as a regulator of the voltage-sensitive calcium channel CACNA1S. EC is a physiological process whereby an electrical signal (depolarization of the plasma membrane) is converted into a chemical signal, a calcium gradient, by the opening of ryanodine receptor calcium release channels. May regulate CACNA1S membrane targeting and activity. {ECO:0000269|PubMed:22927026}.
Q96MK2 RIPOR3 S348 ochoa RIPOR family member 3 None
Q96N67 DOCK7 S190 ochoa Dedicator of cytokinesis protein 7 Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity). {ECO:0000250|UniProtKB:Q8R1A4, ECO:0000269|PubMed:16982419, ECO:0000269|PubMed:29467281}.
Q96PE2 ARHGEF17 S720 ochoa Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}.
Q96PU4 UHRF2 S675 ochoa E3 ubiquitin-protein ligase UHRF2 (EC 2.3.2.27) (Np95/ICBP90-like RING finger protein) (Np95-like RING finger protein) (Nuclear protein 97) (Nuclear zinc finger protein Np97) (RING finger protein 107) (RING-type E3 ubiquitin transferase UHRF2) (Ubiquitin-like PHD and RING finger domain-containing protein 2) (Ubiquitin-like-containing PHD and RING finger domains protein 2) E3 ubiquitin ligase that plays important roles in DNA methylation, histone modifications, cell cycle and DNA repair (PubMed:15178429, PubMed:23404503, PubMed:27743347, PubMed:29506131). Acts as a specific reader for 5-hydroxymethylcytosine (5hmC) and thereby recruits various substrates to these sites to ubiquitinate them (PubMed:24813944, PubMed:27129234). This activity also allows the maintenance of 5mC levels at specific genomic loci and regulates neuron-related gene expression (By similarity). Participates in cell cycle regulation by ubiquitinating cyclins CCND1 and CCNE1 and thereby inducing G1 arrest (PubMed:15178429, PubMed:15361834, PubMed:21952639). Also ubiquitinates PCNP leading to its degradation by the proteasome (PubMed:12176013, PubMed:14741369). Plays an active role in DNA damage repair by ubiquitinating p21/CDKN1A leading to its proteasomal degradation (PubMed:29923055). Also promotes DNA repair by acting as an interstrand cross-links (ICLs) sensor. Mechanistically, cooperates with UHRF1 to ensure recruitment of FANCD2 to ICLs, leading to FANCD2 monoubiquitination and subsequent activation (PubMed:30335751). Contributes to UV-induced DNA damage response by physically interacting with ATR in response to irradiation, thereby promoting ATR activation (PubMed:33848395). {ECO:0000250|UniProtKB:Q7TMI3, ECO:0000269|PubMed:12176013, ECO:0000269|PubMed:14741369, ECO:0000269|PubMed:15178429, ECO:0000269|PubMed:15361834, ECO:0000269|PubMed:21952639, ECO:0000269|PubMed:23404503, ECO:0000269|PubMed:24813944, ECO:0000269|PubMed:27129234, ECO:0000269|PubMed:27743347, ECO:0000269|PubMed:29506131, ECO:0000269|PubMed:29923055, ECO:0000269|PubMed:30335751, ECO:0000269|PubMed:33848395}.
Q96T17 MAP7D2 S195 ochoa MAP7 domain-containing protein 2 Microtubule-stabilizing protein that plays a role in the control of cell motility and neurite outgrowth via direct binding to the microtubule (By similarity). Acts as a critical cofactor for kinesin transport. In the proximal axon, regulates kinesin-1 family members, KIF5A, KIF5B and KIF5C recruitment to microtubules and contributes to kinesin-1-mediated transport in the axons (By similarity). {ECO:0000250|UniProtKB:A2AG50, ECO:0000250|UniProtKB:D4A4L4}.
Q99501 GAS2L1 S360 psp GAS2-like protein 1 (GAS2-related protein on chromosome 22) (Growth arrest-specific protein 2-like 1) Involved in the cross-linking of microtubules and microfilaments (PubMed:12584248, PubMed:24706950). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (PubMed:24706950). {ECO:0000269|PubMed:12584248, ECO:0000269|PubMed:24706950}.
Q9BRD0 BUD13 S407 ochoa BUD13 homolog Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000305|PubMed:33509932}.
Q9BRQ0 PYGO2 S56 ochoa Pygopus homolog 2 Involved in signal transduction through the Wnt pathway.
Q9BS91 SLC35A5 S402 ochoa UDP-sugar transporter protein SLC35A5 (Solute carrier family 35 member A5) Probable UDP-sugar:UMP transmembrane antiporter involved in UDP-alpha-D-glucuronate/UDP-GlcA, UDP-GlcNAc/UDP-N-acetyl-alpha-D-glucosamine and UDP-N-acetyl-alpha-D-galactosamine/UDP-GalNAc transport from the cytosol to the lumen of the Golgi. {ECO:0000269|PubMed:2322548, ECO:0000269|PubMed:30641943}.
Q9BTA9 WAC S72 ochoa WW domain-containing adapter protein with coiled-coil Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1) (PubMed:21329877). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription (PubMed:21329877). Regulates the cell-cycle checkpoint activation in response to DNA damage (PubMed:21329877). Positive regulator of amino acid starvation-induced autophagy (PubMed:22354037). Also acts as a negative regulator of basal autophagy (PubMed:26812014). Positively regulates MTOR activity by promoting, in an energy-dependent manner, the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex. This leads to the dimerization of the mTORC1 complex and its subsequent activation (PubMed:26812014). May negatively regulate the ubiquitin proteasome pathway (PubMed:21329877). {ECO:0000269|PubMed:21329877, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:26812014}.
Q9BXL7 CARD11 S652 psp Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 1) (Carma 1) Adapter protein that plays a key role in adaptive immune response by transducing the activation of NF-kappa-B downstream of T-cell receptor (TCR) and B-cell receptor (BCR) engagement (PubMed:11278692, PubMed:11356195, PubMed:12356734). Transduces signals downstream TCR or BCR activation via the formation of a multiprotein complex together with BCL10 and MALT1 that induces NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11356195). Upon activation in response to TCR or BCR triggering, CARD11 homooligomerizes to form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10 and subsequent recruitment of MALT1: this leads to I-kappa-B kinase (IKK) phosphorylation and degradation, and release of NF-kappa-B proteins for nuclear translocation (PubMed:24074955). Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Promotes linear ubiquitination of BCL10 by promoting the targeting of BCL10 to RNF31/HOIP (PubMed:27777308). Stimulates the phosphorylation of BCL10 (PubMed:11356195). Also activates the TORC1 signaling pathway (PubMed:28628108). {ECO:0000269|PubMed:11278692, ECO:0000269|PubMed:11356195, ECO:0000269|PubMed:12356734, ECO:0000269|PubMed:17287217, ECO:0000269|PubMed:24074955, ECO:0000269|PubMed:27777308, ECO:0000269|PubMed:28628108}.
Q9BY77 POLDIP3 S44 ochoa Polymerase delta-interacting protein 3 (46 kDa DNA polymerase delta interaction protein) (p46) (S6K1 Aly/REF-like target) (SKAR) Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Involved in nuclear mRNA export; probably mediated by association with the TREX complex. {ECO:0000269|PubMed:18423201, ECO:0000269|PubMed:22928037}.
Q9BZW8 CD244 Y342 ochoa Natural killer cell receptor 2B4 (NK cell activation-inducing ligand) (NAIL) (NK cell type I receptor protein 2B4) (NKR2B4) (h2B4) (SLAM family member 4) (SLAMF4) (Signaling lymphocytic activation molecule 4) (CD antigen CD244) Heterophilic receptor of the signaling lymphocytic activation molecule (SLAM) family; its ligand is CD48. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Acts as activating natural killer (NK) cell receptor (PubMed:10359122, PubMed:11714776, PubMed:8376943). Activating function implicates association with SH2D1A and FYN (PubMed:15713798). Downstreaming signaling involves predominantly VAV1, and, to a lesser degree, INPP5D/SHIP1 and CBL. Signal attenuation in the absence of SH2D1A is proposed to be dependent on INPP5D and to a lesser extent PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:10934222, PubMed:15713798). Stimulates NK cell cytotoxicity, production of IFN-gamma and granule exocytosis (PubMed:11714776, PubMed:8376943). Optimal expansion and activation of NK cells seems to be dependent on the engagement of CD244 with CD48 expressed on neighboring NK cells (By similarity). Acts as costimulator in NK activation by enhancing signals by other NK receptors such as NCR3 and NCR1 (PubMed:10741393). At early stages of NK cell differentiation may function as an inhibitory receptor possibly ensuring the self-tolerance of developing NK cells (PubMed:11917118). Involved in the regulation of CD8(+) T-cell proliferation; expression on activated T-cells and binding to CD48 provides costimulatory-like function for neighboring T-cells (By similarity). Inhibits inflammatory responses in dendritic cells (DCs) (By similarity). {ECO:0000250|UniProtKB:Q07763, ECO:0000269|PubMed:10359122, ECO:0000269|PubMed:10741393, ECO:0000269|PubMed:10934222, ECO:0000269|PubMed:11714776, ECO:0000269|PubMed:11917118, ECO:0000269|PubMed:8376943, ECO:0000305|PubMed:15713798}.
Q9C0B0 UNK S240 ochoa RING finger protein unkempt homolog (Zinc finger CCCH domain-containing protein 5) Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280). {ECO:0000269|PubMed:25737280}.
Q9C0B5 ZDHHC5 S537 ochoa Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375) Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, GSDMD, NLRP3, NOD1, NOD2, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, inflammation, fatty acid uptake, bacterial sensing or cardiac functions (PubMed:21820437, PubMed:29185452, PubMed:31402609, PubMed:31649195, PubMed:34293401, PubMed:38092000, PubMed:38530158, PubMed:38599239). Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) (PubMed:26334723). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins (PubMed:26334723). Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2 (PubMed:26334723). Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2 (PubMed:31402609). Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes (PubMed:31649195, PubMed:34293401). Also participates in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane (PubMed:32958780). Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis (PubMed:32958780). Controls oligodendrocyte development by catalyzing STAT3 palmitoylation (By similarity). Acts as a regulator of inflammatory response by mediating palmitoylation of NLRP3 and GSDMD (PubMed:38092000, PubMed:38530158, PubMed:38599239). Palmitoylates NLRP3 to promote inflammasome assembly and activation (PubMed:38092000). Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD), thereby promoting membrane translocation and pore formation of GSDMD (PubMed:38530158, PubMed:38599239). {ECO:0000250|UniProtKB:Q8VDZ4, ECO:0000269|PubMed:21820437, ECO:0000269|PubMed:26334723, ECO:0000269|PubMed:29185452, ECO:0000269|PubMed:31402609, ECO:0000269|PubMed:31649195, ECO:0000269|PubMed:32958780, ECO:0000269|PubMed:34293401, ECO:0000269|PubMed:38092000, ECO:0000269|PubMed:38530158, ECO:0000269|PubMed:38599239}.
Q9C0C2 TNKS1BP1 S437 ochoa 182 kDa tankyrase-1-binding protein None
Q9C0C2 TNKS1BP1 S1054 ochoa 182 kDa tankyrase-1-binding protein None
Q9GZY8 MFF S93 ochoa Mitochondrial fission factor Plays a role in mitochondrial and peroxisomal fission (PubMed:18353969, PubMed:23530241, PubMed:24196833). Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface (PubMed:23530241). May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles (By similarity). {ECO:0000250|UniProtKB:Q4KM98, ECO:0000269|PubMed:18353969, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:24196833}.
Q9H0H5 RACGAP1 S257 ochoa Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP) (Protein CYK4 homolog) (CYK4) (HsCYK-4) Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Sequentially binds to ECT2 and RAB11FIP3 which regulates cleavage furrow ingression and abscission during cytokinesis (PubMed:18511905). Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity (PubMed:10979956). Has a critical role in erythropoiesis (PubMed:34818416). Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells. {ECO:0000269|PubMed:10979956, ECO:0000269|PubMed:11085985, ECO:0000269|PubMed:11278976, ECO:0000269|PubMed:11782313, ECO:0000269|PubMed:14729465, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16129829, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:18511905, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19468302, ECO:0000269|PubMed:23235882, ECO:0000269|PubMed:9497316}.
Q9H1H9 KIF13A S1392 ochoa Kinesin-like protein KIF13A (Kinesin-like protein RBKIN) Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR-containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abscission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis. {ECO:0000269|PubMed:19841138, ECO:0000269|PubMed:20208530}.
Q9H334 FOXP1 S449 ochoa Forkhead box protein P1 (Mac-1-regulated forkhead) (MFH) Transcriptional repressor (PubMed:18347093, PubMed:26647308). Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal cord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintenance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18 (By similarity). Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis (PubMed:25267198). Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor (PubMed:15286807, PubMed:18347093, PubMed:18799727). Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B (PubMed:24023716). Can negatively regulate androgen receptor signaling (PubMed:18640093). Acts as a transcriptional activator of the FBXL7 promoter; this activity is regulated by AURKA (PubMed:28218735). {ECO:0000250|UniProtKB:P58462, ECO:0000269|PubMed:15286807, ECO:0000269|PubMed:18640093, ECO:0000269|PubMed:18799727, ECO:0000269|PubMed:24023716, ECO:0000269|PubMed:25267198, ECO:0000269|PubMed:26647308, ECO:0000269|PubMed:28218735, ECO:0000305|PubMed:18347093, ECO:0000305|PubMed:24023716}.; FUNCTION: [Isoform 8]: Involved in transcriptional regulation in embryonic stem cells (ESCs). Stimulates expression of transcription factors that are required for pluripotency and decreases expression of differentiation-associated genes. Has distinct DNA-binding specifities as compared to the canonical form and preferentially binds DNA with the sequence 5'-CGATACAA-3' (or closely related sequences) (PubMed:21924763). Promotes ESC self-renewal and pluripotency (By similarity). {ECO:0000250|UniProtKB:P58462, ECO:0000269|PubMed:21924763}.
Q9H6F5 CCDC86 S26 ochoa Coiled-coil domain-containing protein 86 (Cytokine-induced protein with coiled-coil domain) Required for proper chromosome segregation during mitosis and error-free mitotic progression. {ECO:0000269|PubMed:36695333}.
Q9H7N4 SCAF1 S622 ochoa Splicing factor, arginine/serine-rich 19 (SR-related C-terminal domain-associated factor 1) (SR-related and CTD-associated factor 1) (SR-related-CTD-associated factor) (SCAF) (Serine arginine-rich pre-mRNA splicing factor SR-A1) (SR-A1) May function in pre-mRNA splicing. {ECO:0000250}.
Q9HCH5 SYTL2 S398 ochoa Synaptotagmin-like protein 2 (Breast cancer-associated antigen SGA-72M) (Exophilin-4) Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive. {ECO:0000269|PubMed:17182843, ECO:0000269|PubMed:18266782, ECO:0000269|PubMed:18812475}.
Q9HCK8 CHD8 S2046 ochoa Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.-) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1) ATP-dependent chromatin-remodeling factor, it slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. Regulates alternative splicing of a core group of genes involved in neuronal differentiation, cell cycle and DNA repair. Enables H3K36me3-coupled transcription elongation and co-transcriptional RNA processing likely via interaction with HNRNPL. {ECO:0000255|HAMAP-Rule:MF_03071, ECO:0000269|PubMed:17938208, ECO:0000269|PubMed:18378692, ECO:0000269|PubMed:28533432, ECO:0000269|PubMed:36537238}.
Q9HD20 ATP13A1 S905 ochoa Endoplasmic reticulum transmembrane helix translocase (EC 7.4.2.-) (Endoplasmic reticulum P5A-ATPase) Endoplasmic reticulum translocase required to remove mitochondrial transmembrane proteins mistargeted to the endoplasmic reticulum (PubMed:32973005, PubMed:36264797). Acts as a dislocase that mediates the ATP-dependent extraction of mislocalized mitochondrial transmembrane proteins from the endoplasmic reticulum membrane (PubMed:32973005). Specifically binds mitochondrial tail-anchored transmembrane proteins: has an atypically large substrate-binding pocket that recognizes and binds moderately hydrophobic transmembranes with short hydrophilic lumenal domains (PubMed:32973005). {ECO:0000269|PubMed:32973005, ECO:0000269|PubMed:36264797}.
Q9NP61 ARFGAP3 S375 ochoa ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3) GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. {ECO:0000269|PubMed:11172815}.
Q9NQX3 GPHN S303 ochoa Gephyrin [Includes: Molybdopterin adenylyltransferase (MPT adenylyltransferase) (EC 2.7.7.75) (Domain G); Molybdopterin molybdenumtransferase (MPT Mo-transferase) (EC 2.10.1.1) (Domain E)] Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Acts as a major instructive molecule at inhibitory synapses, where it also clusters GABA type A receptors (PubMed:25025157, PubMed:26613940). {ECO:0000250|UniProtKB:Q03555, ECO:0000269|PubMed:25025157, ECO:0000269|PubMed:26613940}.; FUNCTION: Also has a catalytic activity and catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. {ECO:0000269|PubMed:26613940}.
Q9NR19 ACSS2 S36 ochoa Acetyl-coenzyme A synthetase, cytoplasmic (EC 6.2.1.1) (Acetate--CoA ligase) (Acetyl-CoA synthetase) (ACS) (AceCS) (Acetyl-CoA synthetase 1) (AceCS1) (Acyl-CoA synthetase short-chain family member 2) (Acyl-activating enzyme) (Propionate--CoA ligase) (EC 6.2.1.17) Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (PubMed:10843999, PubMed:28003429, PubMed:28552616). Acetate is the preferred substrate (PubMed:10843999, PubMed:28003429). Can also utilize propionate with a much lower affinity (By similarity). Nuclear ACSS2 promotes glucose deprivation-induced lysosomal biogenesis and autophagy, tumor cell survival and brain tumorigenesis (PubMed:28552616). Glucose deprivation results in AMPK-mediated phosphorylation of ACSS2 leading to its translocation to the nucleus where it binds to TFEB and locally produces acetyl-CoA for histone acetylation in the promoter regions of TFEB target genes thereby activating their transcription (PubMed:28552616). The regulation of genes associated with autophagy and lysosomal activity through ACSS2 is important for brain tumorigenesis and tumor survival (PubMed:28552616). Acts as a chromatin-bound transcriptional coactivator that up-regulates histone acetylation and expression of neuronal genes (By similarity). Can be recruited to the loci of memory-related neuronal genes to maintain a local acetyl-CoA pool, providing the substrate for histone acetylation and promoting the expression of specific genes, which is essential for maintaining long-term spatial memory (By similarity). {ECO:0000250|UniProtKB:Q9QXG4, ECO:0000269|PubMed:10843999, ECO:0000269|PubMed:28003429, ECO:0000269|PubMed:28552616}.
Q9NR34 MAN1C1 S164 ochoa Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC (EC 3.2.1.113) (HMIC) (Mannosidase alpha class 1C member 1) (Processing alpha-1,2-mannosidase IC) (Alpha-1,2-mannosidase IC) Involved in the maturation of Asn-linked oligosaccharides. Trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce first Man(8)GlcNAc(2) then Man(6)GlcNAc and a small amount of Man(5)GlcNAc.
Q9NR48 ASH1L S1170 ochoa Histone-lysine N-methyltransferase ASH1L (EC 2.1.1.359) (EC 2.1.1.367) (ASH1-like protein) (huASH1) (Absent small and homeotic disks protein 1 homolog) (Lysine N-methyltransferase 2H) Histone methyltransferase specifically trimethylating 'Lys-36' of histone H3 forming H3K36me3 (PubMed:21239497). Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). The physiological significance of the H3K9me1 activity is unclear (By similarity). {ECO:0000250|UniProtKB:Q99MY8, ECO:0000269|PubMed:21239497}.
Q9NRH2 SNRK S563 ochoa SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1-related kinase) May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis. {ECO:0000250|UniProtKB:Q63553, ECO:0000269|PubMed:12234663, ECO:0000269|PubMed:15733851}.
Q9NSK0 KLC4 S598 ochoa Kinesin light chain 4 (KLC 4) (Kinesin-like protein 8) Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity). {ECO:0000250}.
Q9NVN8 GNL3L S519 ochoa Guanine nucleotide-binding protein-like 3-like protein Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP. {ECO:0000269|PubMed:16251348, ECO:0000269|PubMed:17034816, ECO:0000269|PubMed:19487455, ECO:0000269|PubMed:21132010}.
Q9NWZ8 GEMIN8 S170 ochoa Gem-associated protein 8 (Gemin-8) (Protein FAM51A1) The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. {ECO:0000269|PubMed:17023415, ECO:0000269|PubMed:18984161}.
Q9P0V3 SH3BP4 S251 ochoa SH3 domain-binding protein 4 (EH-binding protein 10) (Transferrin receptor-trafficking protein) May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy. {ECO:0000269|PubMed:16325581, ECO:0000269|PubMed:22575674}.
Q9P206 NHSL3 S327 ochoa NHS-like protein 3 Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269|PubMed:32854746}.
Q9P266 JCAD S947 ochoa Junctional cadherin 5-associated protein (Junctional protein associated with coronary artery disease) (JCAD) None
Q9P270 SLAIN2 S374 ochoa SLAIN motif-containing protein 2 Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase. {ECO:0000269|PubMed:21646404}.
Q9P2G1 ANKIB1 S443 ochoa Ankyrin repeat and IBR domain-containing protein 1 (EC 2.3.2.31) Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates. {ECO:0000250}.
Q9UBR4 LHX3 S234 psp LIM/homeobox protein Lhx3 (LIM homeobox protein 3) Transcription factor. Recognizes and binds to the consensus sequence motif 5'-AATTAATTA-3' in the regulatory elements of target genes, such as glycoprotein hormones alpha chain CGA and visual system homeobox CHX10, positively modulating transcription; transcription can be co-activated by LDB2. Synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1 (By similarity). Required for the establishment of the specialized cells of the pituitary gland and the nervous system (PubMed:21149718). Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1 (By similarity). {ECO:0000250|UniProtKB:P50481, ECO:0000269|PubMed:21149718}.
Q9UBU9 NXF1 S62 ochoa Nuclear RNA export factor 1 (Tip-associated protein) (Tip-associating protein) (mRNA export factor TAP) Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway) (PubMed:10924507). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex (PubMed:18364396, PubMed:19165146, PubMed:9660949). ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export (PubMed:18364396, PubMed:19165146, PubMed:9660949). Also involved in nuclear export of m6A-containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). {ECO:0000269|PubMed:10924507, ECO:0000269|PubMed:18364396, ECO:0000269|PubMed:19165146, ECO:0000269|PubMed:28984244, ECO:0000269|PubMed:9660949}.
Q9UG56 PISD S341 ochoa Phosphatidylserine decarboxylase proenzyme, mitochondrial (EC 4.1.1.65) [Cleaved into: Phosphatidylserine decarboxylase beta chain; Phosphatidylserine decarboxylase alpha chain] Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) (PubMed:30488656, PubMed:30858161). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. May be involved in lipid droplet biogenesis at the endoplasmic reticulum membrane (By similarity). {ECO:0000250|UniProtKB:A0A8H4BVL9, ECO:0000255|HAMAP-Rule:MF_03208, ECO:0000269|PubMed:30488656, ECO:0000269|PubMed:30858161}.
Q9UGP4 LIMD1 S304 ochoa LIM domain-containing protein 1 Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation. {ECO:0000269|PubMed:15542589, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22286099}.
Q9UH92 MLX S106 ochoa Max-like protein X (Class D basic helix-loop-helix protein 13) (bHLHd13) (Max-like bHLHZip protein) (Protein BigMax) (Transcription factor-like protein 4) Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MAD1, MAD4, MNT, WBSCR14 and MLXIP which recognizes the core sequence 5'-CACGTG-3'. The TCFL4-MAD1, TCFL4-MAD4, TCFL4-WBSCR14 complexes are transcriptional repressors. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation. {ECO:0000269|PubMed:10593926, ECO:0000269|PubMed:12446771, ECO:0000269|PubMed:16782875}.
Q9UHB6 LIMA1 S346 ochoa LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}.
Q9UJD0 RIMS3 S116 ochoa Regulating synaptic membrane exocytosis protein 3 (Nim3) (RIM3 gamma) (Rab-3-interacting molecule 3) (RIM 3) Regulates synaptic membrane exocytosis. {ECO:0000250}.
Q9UJF2 RASAL2 S928 ochoa Ras GTPase-activating protein nGAP (RAS protein activator-like 2) Inhibitory regulator of the Ras-cyclic AMP pathway.
Q9UJK0 TSR3 S267 ochoa 18S rRNA aminocarboxypropyltransferase (EC 2.5.1.157) (20S S rRNA accumulation protein 3 homolog) (HsTsr3) Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1248 (Psi1248) in 18S rRNA (Probable). It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA (Probable). {ECO:0000305|PubMed:27084949}.
Q9UJY4 GGA2 S334 ochoa ADP-ribosylation factor-binding protein GGA2 (Gamma-adaptin-related protein 2) (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (VHS domain and ear domain of gamma-adaptin) (Vear) Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:10747088). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:27901063). Regulates retrograde transport of phosphorylated form of BACE1 from endosomes to the trans-Golgi network (PubMed:15615712). {ECO:0000269|PubMed:10747088, ECO:0000269|PubMed:15615712, ECO:0000269|PubMed:27901063}.
Q9UKJ3 GPATCH8 S758 ochoa G patch domain-containing protein 8 None
Q9UKV3 ACIN1 S990 ochoa Apoptotic chromatin condensation inducer in the nucleus (Acinus) Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}.
Q9ULH0 KIDINS220 T890 ochoa Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. {ECO:0000250, ECO:0000269|PubMed:18089783}.
Q9ULH1 ASAP1 S746 ochoa Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP) Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:25673879). {ECO:0000250, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:25673879}.
Q9UNI6 DUSP12 S241 ochoa Dual specificity protein phosphatase 12 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity tyrosine phosphatase YVH1) Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues. Can dephosphorylate glucokinase (in vitro) (By similarity). Has phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate and other in vitro substrates (PubMed:10446167, PubMed:24531476). {ECO:0000250|UniProtKB:Q9JIM4, ECO:0000269|PubMed:10446167, ECO:0000269|PubMed:24531476}.
Q9UP95 SLC12A4 S24 ochoa Solute carrier family 12 member 4 (Electroneutral potassium-chloride cotransporter 1) (Erythroid K-Cl cotransporter 1) (hKCC1) Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:35759661). May contribute to cell volume homeostasis in single cells (PubMed:10913127, PubMed:34031912). May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity). {ECO:0000250|UniProtKB:Q9JIS8, ECO:0000269|PubMed:10913127, ECO:0000269|PubMed:34031912, ECO:0000269|PubMed:35759661}.; FUNCTION: [Isoform 4]: No transporter activity. {ECO:0000269|PubMed:11551954}.
Q9UQ35 SRRM2 S2415 ochoa Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q9UQC2 GAB2 S218 ochoa GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100) Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. {ECO:0000269|PubMed:15750601, ECO:0000269|PubMed:19172738}.
Q9Y2I9 TBC1D30 S122 ochoa TBC1 domain family member 30 May act as a GTPase-activating protein for Rab family protein(s). {ECO:0000305}.
Q9Y2K6 USP20 S341 ochoa Ubiquitin carboxyl-terminal hydrolase 20 (EC 3.4.19.12) (Deubiquitinating enzyme 20) (Ubiquitin thioesterase 20) (Ubiquitin-specific-processing protease 20) (VHL-interacting deubiquitinating enzyme 2) (hVDU2) Deubiquitinating enzyme that plays a role in many cellular processes including autophagy, cellular antiviral response or membrane protein biogenesis (PubMed:27801882, PubMed:29487085). Attenuates TLR4-mediated NF-kappa-B signaling by cooperating with beta-arrestin-2/ARRB2 and inhibiting TRAF6 autoubiquitination (PubMed:26839314). Promotes cellular antiviral responses by deconjugating 'Lys-33' and 'Lys-48'-linked ubiquitination of STING1 leading to its stabilization (PubMed:27801882). Plays an essential role in autophagy induction by regulating the ULK1 stability through deubiquitination of ULK1 (PubMed:29487085). Acts as a positive regulator for NF-kappa-B activation by TNF-alpha through deubiquitinating 'Lys-48'-linked polyubiquitination of SQSTM1, leading to its increased stability (PubMed:32354117). Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2) (PubMed:19424180). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2 (PubMed:19424180). This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity (PubMed:15776016). Deubiquitinates MCL1, a pivotal member of the anti-apoptotic Bcl-2 protein family to regulate its stability (PubMed:35063767). Within the endoplasmic reticulum, participates with USP33 in the rescue of post-translationally targeted membrane proteins that are inappropriately ubiquitinated by the cytosolic protein quality control in the cytosol (PubMed:33792613). {ECO:0000269|PubMed:12056827, ECO:0000269|PubMed:12865408, ECO:0000269|PubMed:15776016, ECO:0000269|PubMed:19424180, ECO:0000269|PubMed:26839314, ECO:0000269|PubMed:27801882, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:32354117, ECO:0000269|PubMed:33792613, ECO:0000269|PubMed:35063767}.
Q9Y2L6 FRMD4B S774 ochoa FERM domain-containing protein 4B (GRP1-binding protein GRSP1) Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex. Plays a redundant role with FRMD4A in epithelial polarization. {ECO:0000250|UniProtKB:Q920B0}.
Q9Y426 C2CD2 S519 ochoa C2 domain-containing protein 2 (Transmembrane protein 24-like) None
Q9Y4B6 DCAF1 S987 ochoa DDB1- and CUL4-associated factor 1 (HIV-1 Vpr-binding protein) (VprBP) (Serine/threonine-protein kinase VPRBP) (EC 2.7.11.1) (Vpr-interacting protein) Acts both as a substrate recognition component of E3 ubiquitin-protein ligase complexes and as an atypical serine/threonine-protein kinase, playing key roles in various processes such as cell cycle, telomerase regulation and histone modification. Probable substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, named CUL4A-RBX1-DDB1-DCAF1/VPRBP complex, which mediates ubiquitination and proteasome-dependent degradation of proteins such as NF2 (PubMed:23063525). Involved in the turnover of methylated proteins: recognizes and binds methylated proteins via its chromo domain, leading to ubiquitination of target proteins by the RBX1-DDB1-DCAF1/VPRBP complex (PubMed:23063525). The CUL4A-RBX1-DDB1-DCAF1/VPRBP complex is also involved in B-cell development: DCAF1 is recruited by RAG1 to ubiquitinate proteins, leading to limit error-prone repair during V(D)J recombination (By similarity). Also part of the EDVP complex, an E3 ligase complex that mediates ubiquitination of proteins such as TERT, leading to TERT degradation and telomerase inhibition (PubMed:19287380, PubMed:23362280). The EDVP complex also mediates ubiquitination and degradation of CCP110 (PubMed:28242748, PubMed:34259627). Also acts as an atypical serine/threonine-protein kinase that specifically mediates phosphorylation of 'Thr-120' of histone H2A (H2AT120ph) in a nucleosomal context, thereby repressing transcription (PubMed:24140421). H2AT120ph is present in the regulatory region of many tumor suppresor genes, down-regulates their transcription and is present at high level in a number of tumors (PubMed:24140421). Involved in JNK-mediated apoptosis during cell competition process via its interaction with LLGL1 and LLGL2 (PubMed:20644714). By acting on TET dioxygenses, essential for oocyte maintenance at the primordial follicle stage, hence essential for female fertility (By similarity). {ECO:0000250|UniProtKB:Q80TR8, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:17609381, ECO:0000269|PubMed:17630831, ECO:0000269|PubMed:18332868, ECO:0000269|PubMed:18524771, ECO:0000269|PubMed:18606781, ECO:0000269|PubMed:19287380, ECO:0000269|PubMed:20644714, ECO:0000269|PubMed:22184063, ECO:0000269|PubMed:23063525, ECO:0000269|PubMed:23362280, ECO:0000269|PubMed:24140421, ECO:0000269|PubMed:28242748, ECO:0000269|PubMed:34259627}.; FUNCTION: (Microbial infection) In case of infection by HIV-1 virus, it is recruited by HIV-1 Vpr in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to arrest the cell cycle in G2 phase, and also to protect the viral protein from proteasomal degradation by another E3 ubiquitin ligase. The HIV-1 Vpr protein hijacks the CUL4A-RBX1-DDB1-DCAF1/VPRBP complex to promote ubiquitination and degradation of proteins such as TERT and ZIP/ZGPAT. {ECO:0000269|PubMed:17314515, ECO:0000269|PubMed:17559673, ECO:0000269|PubMed:17609381, ECO:0000269|PubMed:17620334, ECO:0000269|PubMed:17626091, ECO:0000269|PubMed:17630831, ECO:0000269|PubMed:18524771, ECO:0000269|PubMed:24116224}.; FUNCTION: (Microbial infection) In case of infection by HIV-2 virus, it is recruited by HIV-2 Vpx in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to enhanced efficiency of macrophage infection and promotion of the replication of cognate primate lentiviruses in cells of monocyte/macrophage lineage. {ECO:0000269|PubMed:17314515, ECO:0000269|PubMed:18464893, ECO:0000269|PubMed:19264781, ECO:0000269|PubMed:19923175, ECO:0000269|PubMed:24336198}.
Q9Y4F5 CEP170B S711 ochoa Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}.
Q9Y4F9 RIPOR2 S593 ochoa Rho family-interacting cell polarization regulator 2 Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization (PubMed:17150207, PubMed:23241886, PubMed:24687993, PubMed:24958875, PubMed:25588844, PubMed:27556504). Inhibits chemokine-induced T lymphocyte responses, such as cell adhesion, polarization and migration (PubMed:23241886). Involved also in the regulation of neutrophil polarization, chemotaxis and adhesion (By similarity). Required for normal development of inner and outer hair cell stereocilia within the cochlea of the inner ear (By similarity). Plays a role for maintaining the structural organization of the basal domain of stereocilia (By similarity). Involved in mechanosensory hair cell function (By similarity). Required for normal hearing (PubMed:24958875). {ECO:0000250|UniProtKB:Q80U16, ECO:0000269|PubMed:17150207, ECO:0000269|PubMed:23241886, ECO:0000269|PubMed:24687993, ECO:0000269|PubMed:24958875, ECO:0000269|PubMed:27556504}.; FUNCTION: [Isoform 2]: Acts as an inhibitor of the small GTPase RHOA (PubMed:25588844). Plays a role in fetal mononuclear myoblast differentiation by promoting filopodia and myotube formation (PubMed:17150207). Maintains naive T lymphocytes in a quiescent state (PubMed:27556504). {ECO:0000269|PubMed:17150207, ECO:0000269|PubMed:25588844, ECO:0000269|PubMed:27556504}.
Q9Y570 PPME1 S27 ochoa Protein phosphatase methylesterase 1 (PME-1) (EC 3.1.1.89) Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme. {ECO:0000269|PubMed:10318862}.
Q9Y6R9 CCDC61 S381 ochoa Centrosomal protein CCDC61 (Coiled-coil domain-containing protein 61) (VFL3 homolog) Microtubule-binding centrosomal protein required for centriole cohesion, independently of the centrosome-associated protein/CEP250 and rootletin/CROCC linker (PubMed:31789463). In interphase, required for anchoring microtubule at the mother centriole subdistal appendages and for centrosome positioning (PubMed:31789463). During mitosis, may be involved in spindle assembly and chromatin alignment by regulating the organization of spindle microtubules into a symmetrical structure (PubMed:30354798). Has been proposed to play a role in CEP170 recruitment to centrosomes (PubMed:30354798). However, this function could not be confirmed (PubMed:31789463). Plays a non-essential role in ciliogenesis (PubMed:31789463, PubMed:32375023). {ECO:0000269|PubMed:30354798, ECO:0000269|PubMed:31789463, ECO:0000269|PubMed:32375023}.
Q96RT7 TUBGCP6 S1060 SIGNOR Gamma-tubulin complex component 6 (GCP-6) Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:11694571, PubMed:38305685, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685, PubMed:38609661, PubMed:39321809). {ECO:0000269|PubMed:11694571, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}.
Q96RT7 TUBGCP6 S1087 SIGNOR Gamma-tubulin complex component 6 (GCP-6) Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:11694571, PubMed:38305685, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685, PubMed:38609661, PubMed:39321809). {ECO:0000269|PubMed:11694571, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}.
Q96RT7 TUBGCP6 S1114 SIGNOR Gamma-tubulin complex component 6 (GCP-6) Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:11694571, PubMed:38305685, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685, PubMed:38609661, PubMed:39321809). {ECO:0000269|PubMed:11694571, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}.
Q96RT7 TUBGCP6 S1168 SIGNOR Gamma-tubulin complex component 6 (GCP-6) Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:11694571, PubMed:38305685, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685, PubMed:38609661, PubMed:39321809). {ECO:0000269|PubMed:11694571, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}.
Q96RT7 TUBGCP6 S1195 SIGNOR Gamma-tubulin complex component 6 (GCP-6) Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:11694571, PubMed:38305685, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685, PubMed:38609661, PubMed:39321809). {ECO:0000269|PubMed:11694571, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}.
Q96RT7 TUBGCP6 S1249 SIGNOR Gamma-tubulin complex component 6 (GCP-6) Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:11694571, PubMed:38305685, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685, PubMed:38609661, PubMed:39321809). {ECO:0000269|PubMed:11694571, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}.
P53350 PLK1 S529 SIGNOR Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13) Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis (PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:23455478, PubMed:23509069, PubMed:28512243, PubMed:8991084). Polo-like kinase proteins act by binding and phosphorylating proteins that are already phosphorylated on a specific motif recognized by the POLO box domains (PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:23455478, PubMed:23509069, PubMed:28512243, PubMed:8991084). Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, MRE11, PPP1R12A/MYPT1, POLQ, PRC1, RACGAP1/CYK4, RAD51, RHNO1, SGO1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1, WEE1 and HNRNPU (PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17218258, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:22325354, PubMed:23455478, PubMed:23509069, PubMed:25986610, PubMed:26811421, PubMed:28512243, PubMed:37440612, PubMed:37674080, PubMed:8991084). Plays a key role in centrosome functions and the assembly of bipolar spindles by phosphorylating KIZ, NEDD1 and NINL (PubMed:16980960, PubMed:19509060). NEDD1 phosphorylation promotes subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation (PubMed:19509060). Phosphorylation of NINL component of the centrosome leads to NINL dissociation from other centrosomal proteins (PubMed:12852856). Involved in mitosis exit and cytokinesis by phosphorylating CEP55, ECT2, KIF20A/MKLP2, CENPU, PRC1 and RACGAP1 (PubMed:12939256, PubMed:16247472, PubMed:17351640, PubMed:19468300, PubMed:19468302). Recruited at the central spindle by phosphorylating and docking PRC1 and KIF20A/MKLP2; creates its own docking sites on PRC1 and KIF20A/MKLP2 by mediating phosphorylation of sites subsequently recognized by the POLO box domains (PubMed:12939256, PubMed:17351640). Phosphorylates RACGAP1, thereby creating a docking site for the Rho GTP exchange factor ECT2 that is essential for the cleavage furrow formation (PubMed:19468300, PubMed:19468302). Promotes the central spindle recruitment of ECT2 (PubMed:16247472). Plays a central role in G2/M transition of mitotic cell cycle by phosphorylating CCNB1, CDC25C, FOXM1, CENPU, PKMYT1/MYT1, PPP1R12A/MYPT1 and WEE1 (PubMed:11202906, PubMed:12447691, PubMed:12524548, PubMed:19160488). Part of a regulatory circuit that promotes the activation of CDK1 by phosphorylating the positive regulator CDC25C and inhibiting the negative regulators WEE1 and PKMYT1/MYT1 (PubMed:11202906). Also acts by mediating phosphorylation of cyclin-B1 (CCNB1) on centrosomes in prophase (PubMed:12447691, PubMed:12524548). Phosphorylates FOXM1, a key mitotic transcription regulator, leading to enhance FOXM1 transcriptional activity (PubMed:19160488). Involved in kinetochore functions and sister chromatid cohesion by phosphorylating BUB1B/BUBR1, FBXO5/EMI1 and STAG2/SA2 (PubMed:15148369, PubMed:15469984, PubMed:17376779, PubMed:18331714). PLK1 is high on non-attached kinetochores suggesting a role of PLK1 in kinetochore attachment or in spindle assembly checkpoint (SAC) regulation (PubMed:17617734). Required for kinetochore localization of BUB1B (PubMed:17376779). Regulates the dissociation of cohesin from chromosomes by phosphorylating cohesin subunits such as STAG2/SA2 (By similarity). Phosphorylates SGO1: required for spindle pole localization of isoform 3 of SGO1 and plays a role in regulating its centriole cohesion function (PubMed:18331714). Mediates phosphorylation of FBXO5/EMI1, a negative regulator of the APC/C complex during prophase, leading to FBXO5/EMI1 ubiquitination and degradation by the proteasome (PubMed:15148369, PubMed:15469984). Acts as a negative regulator of p53 family members: phosphorylates TOPORS, leading to inhibit the sumoylation of p53/TP53 and simultaneously enhance the ubiquitination and subsequent degradation of p53/TP53 (PubMed:19473992). Phosphorylates the transactivation domain of the transcription factor p73/TP73, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates BORA, and thereby promotes the degradation of BORA (PubMed:18521620). Contributes to the regulation of AURKA function (PubMed:18615013, PubMed:18662541). Also required for recovery after DNA damage checkpoint and entry into mitosis (PubMed:18615013, PubMed:18662541). Phosphorylates MISP, leading to stabilization of cortical and astral microtubule attachments required for proper spindle positioning (PubMed:23509069). Together with MEIKIN, acts as a regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage (By similarity). Phosphorylates CEP68 and is required for its degradation (PubMed:25503564). Regulates nuclear envelope breakdown during prophase by phosphorylating DCTN1 resulting in its localization in the nuclear envelope (PubMed:20679239). Phosphorylates the heat shock transcription factor HSF1, promoting HSF1 nuclear translocation upon heat shock (PubMed:15661742). Phosphorylates HSF1 also in the early mitotic period; this phosphorylation regulates HSF1 localization to the spindle pole, the recruitment of the SCF(BTRC) ubiquitin ligase complex induicing HSF1 degradation, and hence mitotic progression (PubMed:18794143). Regulates mitotic progression by phosphorylating RIOK2 (PubMed:21880710). Through the phosphorylation of DZIP1 regulates the localization during mitosis of the BBSome, a ciliary protein complex involved in cilium biogenesis (PubMed:27979967). Regulates DNA repair during mitosis by mediating phosphorylation of POLQ and RHNO1, thereby promoting POLQ recruitment to DNA damage sites (PubMed:37440612, PubMed:37674080). Phosphorylates ATXN10 which may play a role in the regulation of cytokinesis and may stimulate the proteasome-mediated degradation of ATXN10 (PubMed:21857149). {ECO:0000250|UniProtKB:P70032, ECO:0000250|UniProtKB:Q5F2C3, ECO:0000269|PubMed:11202906, ECO:0000269|PubMed:12207013, ECO:0000269|PubMed:12447691, ECO:0000269|PubMed:12524548, ECO:0000269|PubMed:12738781, ECO:0000269|PubMed:12852856, ECO:0000269|PubMed:12939256, ECO:0000269|PubMed:14532005, ECO:0000269|PubMed:14734534, ECO:0000269|PubMed:15070733, ECO:0000269|PubMed:15148369, ECO:0000269|PubMed:15469984, ECO:0000269|PubMed:15661742, ECO:0000269|PubMed:16198290, ECO:0000269|PubMed:16247472, ECO:0000269|PubMed:16980960, ECO:0000269|PubMed:17081991, ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:17351640, ECO:0000269|PubMed:17376779, ECO:0000269|PubMed:17617734, ECO:0000269|PubMed:18174154, ECO:0000269|PubMed:18331714, ECO:0000269|PubMed:18418051, ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:18521620, ECO:0000269|PubMed:18615013, ECO:0000269|PubMed:18662541, ECO:0000269|PubMed:18794143, ECO:0000269|PubMed:19160488, ECO:0000269|PubMed:19351716, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19468302, ECO:0000269|PubMed:19473992, ECO:0000269|PubMed:19509060, ECO:0000269|PubMed:19597481, ECO:0000269|PubMed:20679239, ECO:0000269|PubMed:21857149, ECO:0000269|PubMed:21880710, ECO:0000269|PubMed:22325354, ECO:0000269|PubMed:23455478, ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:25986610, ECO:0000269|PubMed:26811421, ECO:0000269|PubMed:27979967, ECO:0000269|PubMed:37440612, ECO:0000269|PubMed:37674080, ECO:0000269|PubMed:8991084}.
O15075 DCLK1 S172 Sugiyama Serine/threonine-protein kinase DCLK1 (EC 2.7.11.1) (Doublecortin domain-containing protein 3A) (Doublecortin-like and CAM kinase-like 1) (Doublecortin-like kinase 1) Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system.
P48426 PIP4K2A S115 Sugiyama Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha) (Diphosphoinositide kinase 2-alpha) (PIP5KIII) (Phosphatidylinositol 5-Phosphate 4-Kinase) (PI5P4Kalpha) (Phosphatidylinositol 5-phosphate 4-kinase type II alpha) (PI(5)P 4-kinase type II alpha) (PIP4KII-alpha) (PtdIns(4)P-5-kinase B isoform) (PtdIns(4)P-5-kinase C isoform) (PtdIns(5)P-4-kinase isoform 2-alpha) Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) (PubMed:23326584, PubMed:9367159). Has both ATP- and GTP-dependent kinase activities (PubMed:26774281). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2 (PubMed:18364242). May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation (By similarity). Required for lysosome-peroxisome membrane contacts and intracellular cholesterol transport through modulating peroxisomal PtdIns(4,5)P2 level (PubMed:29353240). In collaboration with PIP4K2B, has a role in mediating autophagy in times of nutrient stress (By similarity). Required for autophagosome-lysosome fusion and the regulation of cellular lipid metabolism (PubMed:31091439). May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size (By similarity). Negatively regulates insulin signaling through a catalytic-independent mechanism (PubMed:31091439). PIP4Ks interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (PubMed:31091439). {ECO:0000250|UniProtKB:O70172, ECO:0000250|UniProtKB:Q9R0I8, ECO:0000269|PubMed:18364242, ECO:0000269|PubMed:23326584, ECO:0000269|PubMed:26774281, ECO:0000269|PubMed:29353240, ECO:0000269|PubMed:31091439, ECO:0000269|PubMed:9367159}.
Q92974 ARHGEF2 S896 GPS6|EPSD Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) (Microtubule-regulated Rho-GEF) (Proliferating cell nucleolar antigen p40) Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed:9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF activity and the activation of RhoA. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability (By similarity). Involved in neuronal progenitor cell division and differentiation (PubMed:28453519). Involved in the migration of precerebellar neurons (By similarity). {ECO:0000250|UniProtKB:Q60875, ECO:0000250|UniProtKB:Q865S3, ECO:0000269|PubMed:19043560, ECO:0000269|PubMed:21887730, ECO:0000269|PubMed:28453519, ECO:0000269|PubMed:9857026}.
P35368 ADRA1B S410 SIGNOR|iPTMNet|EPSD Alpha-1B adrenergic receptor (Alpha-1B adrenoreceptor) (Alpha-1B adrenoceptor) This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes. {ECO:0000269|PubMed:18802028, ECO:0000269|PubMed:22120526}.
O60343 TBC1D4 S759 Sugiyama TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160) May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake. {ECO:0000269|PubMed:15971998, ECO:0000269|PubMed:18771725, ECO:0000269|PubMed:22908308}.
P27448 MARK3 S610 Sugiyama MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (C-TAK1) (cTAK1) (Cdc25C-associated protein kinase 1) (ELKL motif kinase 2) (EMK-2) (Protein kinase STK10) (Ser/Thr protein kinase PAR-1) (Par-1a) (Serine/threonine-protein kinase p78) Serine/threonine-protein kinase (PubMed:16822840, PubMed:16980613, PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Phosphorylates CDC25C on 'Ser-216' (PubMed:12941695). Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol (PubMed:16822840). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714). Phosphorylates PKP2 and KSR1 (PubMed:12941695). {ECO:0000269|PubMed:12941695, ECO:0000269|PubMed:16822840, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:23666762, ECO:0000269|PubMed:28087714}.
P35568 IRS1 S315 SIGNOR Insulin receptor substrate 1 (IRS-1) Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:19639489, ECO:0000269|PubMed:38625937, ECO:0000269|PubMed:7541045, ECO:0000269|PubMed:8265614}.
P53671 LIMK2 S22 Sugiyama LIM domain kinase 2 (LIMK-2) (EC 2.7.11.1) Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics (PubMed:10436159, PubMed:11018042). Acts downstream of several Rho family GTPase signal transduction pathways (PubMed:10436159, PubMed:11018042). Involved in astral microtubule organization and mitotic spindle orientation during early stages of mitosis by mediating phosphorylation of TPPP (PubMed:22328514). Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro (PubMed:8537403). Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of directional trafficking of ciliary vesicles to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (PubMed:25849865). {ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:11018042, ECO:0000269|PubMed:22328514, ECO:0000269|PubMed:25849865, ECO:0000269|PubMed:8537403}.
P0CAP2 POLR2M S187 Sugiyama DNA-directed RNA polymerase II subunit GRINL1A (DNA-directed RNA polymerase II subunit M) (Glutamate receptor-like protein 1A) [Isoform 1]: Appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II). Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. May play a role in the Mediator complex-dependent regulation of transcription activation. Acts as a negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II. {ECO:0000269|PubMed:16769904, ECO:0000269|PubMed:30190596}.
Q08881 ITK S204 Sugiyama Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (Interleukin-2-inducible T-cell kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation (PubMed:12186560, PubMed:12682224, PubMed:21725281). Required for TCR-mediated calcium response in gamma-delta T-cells, may also be involved in the modulation of the transcriptomic signature in the Vgamma2-positive subset of immature gamma-delta T-cells (By similarity). Phosphorylates TBX21 at 'Tyr-530' and mediates its interaction with GATA3 (By similarity). {ECO:0000250|UniProtKB:Q03526, ECO:0000269|PubMed:12186560, ECO:0000269|PubMed:12682224, ECO:0000269|PubMed:21725281}.
Q99759 MAP3K3 S345 Sugiyama Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3) Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators. {ECO:0000269|PubMed:12912994, ECO:0000269|PubMed:14661019, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:33729480, ECO:0000269|PubMed:33891857, ECO:0000269|PubMed:9006902}.
Q15303 ERBB4 S1123 Sugiyama Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)] Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration. Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote nuclear import of STAT5A, activation of STAT5A, mammary epithelium differentiation, cell proliferation and activation of gene expression. The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactation. The ERBB4 soluble intracellular domains can also translocate to mitochondria and promote apoptosis. {ECO:0000269|PubMed:10348342, ECO:0000269|PubMed:10353604, ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:10722704, ECO:0000269|PubMed:10867024, ECO:0000269|PubMed:11178955, ECO:0000269|PubMed:11390655, ECO:0000269|PubMed:12807903, ECO:0000269|PubMed:15534001, ECO:0000269|PubMed:15746097, ECO:0000269|PubMed:16251361, ECO:0000269|PubMed:16778220, ECO:0000269|PubMed:16837552, ECO:0000269|PubMed:17486069, ECO:0000269|PubMed:17638867, ECO:0000269|PubMed:19098003, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:8383326, ECO:0000269|PubMed:8617750, ECO:0000269|PubMed:9135143, ECO:0000269|PubMed:9168115, ECO:0000269|PubMed:9334263}.
P78356 PIP4K2B S120 Sugiyama Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-beta) (Diphosphoinositide kinase 2-beta) (Phosphatidylinositol 5-phosphate 4-kinase type II beta) (PI(5)P 4-kinase type II beta) (PIP4KII-beta) (PtdIns(5)P-4-kinase isoform 2-beta) Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate (PubMed:26774281, PubMed:9038203). Preferentially utilizes GTP, rather than ATP, for PI(5)P phosphorylation and its activity reflects changes in direct proportion to the physiological GTP concentration (PubMed:26774281). Its GTP-sensing activity is critical for metabolic adaptation (PubMed:26774281). PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (PubMed:31091439). {ECO:0000269|PubMed:26774281, ECO:0000269|PubMed:31091439, ECO:0000269|PubMed:9038203}.
Q92630 DYRK2 S474 Sugiyama Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1) Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at 'Ser-46', and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. Phosphorylates EIF2B5 at 'Ser-544', enabling its subsequent phosphorylation and inhibition by GSK3B. Likewise, phosphorylation of NFATC1, CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B. May play a general role in the priming of GSK3 substrates. Inactivates GYS1 by phosphorylation at 'Ser-641', and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Mediates EDVP E3 ligase complex formation and is required for the phosphorylation and subsequent degradation of KATNA1. Phosphorylates TERT at 'Ser-457', promoting TERT ubiquitination by the EDVP complex. Phosphorylates SIAH2, and thereby increases its ubiquitin ligase activity. Promotes the proteasomal degradation of MYC and JUN, and thereby regulates progress through the mitotic cell cycle and cell proliferation. Promotes proteasomal degradation of GLI2 and GLI3, and thereby plays a role in smoothened and sonic hedgehog signaling. Plays a role in cytoskeleton organization and neurite outgrowth via its phosphorylation of DCX and DPYSL2. Phosphorylates CRMP2/DPYSL2, CRMP4/DPYSL3, DCX, EIF2B5, EIF4EBP1, GLI2, GLI3, GYS1, JUN, MDM2, MYC, NFATC1, p53/TP53, TAU/MAPT and KATNA1. Can phosphorylate histone H1, histone H3 and histone H2B (in vitro). Can phosphorylate CARHSP1 (in vitro). {ECO:0000269|PubMed:11311121, ECO:0000269|PubMed:12588975, ECO:0000269|PubMed:14593110, ECO:0000269|PubMed:15910284, ECO:0000269|PubMed:16511445, ECO:0000269|PubMed:16611631, ECO:0000269|PubMed:17349958, ECO:0000269|PubMed:18455992, ECO:0000269|PubMed:18599021, ECO:0000269|PubMed:19287380, ECO:0000269|PubMed:22307329, ECO:0000269|PubMed:22878263, ECO:0000269|PubMed:23362280, ECO:0000269|PubMed:9748265}.
Q96RR4 CAMKK2 S503 Sugiyama Calcium/calmodulin-dependent protein kinase kinase 2 (CaM-KK 2) (CaM-kinase kinase 2) (CaMKK 2) (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-KK beta) (CaM-kinase kinase beta) (CaMKK beta) Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching. {ECO:0000250, ECO:0000269|PubMed:11395482, ECO:0000269|PubMed:12935886, ECO:0000269|PubMed:21957496, ECO:0000269|PubMed:9662074}.
Download
reactome_id name p -log10_p
R-HSA-162582 Signal Transduction 9.288218e-07 6.032
R-HSA-8935964 RUNX1 regulates expression of components of tight junctions 1.387789e-05 4.858
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 1.507712e-05 4.822
R-HSA-9649948 Signaling downstream of RAS mutants 5.455998e-05 4.263
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 5.206767e-05 4.283
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 5.455998e-05 4.263
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 5.455998e-05 4.263
R-HSA-5674135 MAP2K and MAPK activation 2.975013e-05 4.527
R-HSA-6802957 Oncogenic MAPK signaling 4.631320e-05 4.334
R-HSA-6802949 Signaling by RAS mutants 5.455998e-05 4.263
R-HSA-9018519 Estrogen-dependent gene expression 9.724733e-05 4.012
R-HSA-9656223 Signaling by RAF1 mutants 2.522519e-04 3.598
R-HSA-438064 Post NMDA receptor activation events 3.308330e-04 3.480
R-HSA-5673001 RAF/MAP kinase cascade 4.185384e-04 3.378
R-HSA-5684996 MAPK1/MAPK3 signaling 5.259617e-04 3.279
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 5.561844e-04 3.255
R-HSA-5683057 MAPK family signaling cascades 8.502475e-04 3.070
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 8.641436e-04 3.063
R-HSA-1253288 Downregulation of ERBB4 signaling 1.012045e-03 2.995
R-HSA-196025 Formation of annular gap junctions 1.012045e-03 2.995
R-HSA-442729 CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde 1.012045e-03 2.995
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 9.477356e-04 3.023
R-HSA-190873 Gap junction degradation 1.297167e-03 2.887
R-HSA-9619229 Activation of RAC1 downstream of NMDARs 1.297167e-03 2.887
R-HSA-111932 CaMK IV-mediated phosphorylation of CREB 1.628236e-03 2.788
R-HSA-5675221 Negative regulation of MAPK pathway 1.837010e-03 2.736
R-HSA-8939211 ESR-mediated signaling 2.127864e-03 2.672
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 2.605954e-03 2.584
R-HSA-1489509 DAG and IP3 signaling 2.571522e-03 2.590
R-HSA-9664565 Signaling by ERBB2 KD Mutants 3.521753e-03 2.453
R-HSA-210745 Regulation of gene expression in beta cells 3.521753e-03 2.453
R-HSA-8847993 ERBB2 Activates PTK6 Signaling 4.054643e-03 2.392
R-HSA-1250196 SHC1 events in ERBB2 signaling 3.889000e-03 2.410
R-HSA-1227990 Signaling by ERBB2 in Cancer 3.889000e-03 2.410
R-HSA-416482 G alpha (12/13) signalling events 4.334580e-03 2.363
R-HSA-191650 Regulation of gap junction activity 5.097436e-03 2.293
R-HSA-6785631 ERBB2 Regulates Cell Motility 4.708255e-03 2.327
R-HSA-9705677 SARS-CoV-2 targets PDZ proteins in cell-cell junction 5.097436e-03 2.293
R-HSA-9006925 Intracellular signaling by second messengers 5.065291e-03 2.295
R-HSA-446353 Cell-extracellular matrix interactions 4.708255e-03 2.327
R-HSA-193648 NRAGE signals death through JNK 5.663053e-03 2.247
R-HSA-1250347 SHC1 events in ERBB4 signaling 6.197260e-03 2.208
R-HSA-1963640 GRB2 events in ERBB2 signaling 6.197260e-03 2.208
R-HSA-1963642 PI3K events in ERBB2 signaling 7.035396e-03 2.153
R-HSA-1227986 Signaling by ERBB2 7.253325e-03 2.139
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 7.792857e-03 2.108
R-HSA-2219528 PI3K/AKT Signaling in Cancer 9.119885e-03 2.040
R-HSA-1251985 Nuclear signaling by ERBB4 9.745601e-03 2.011
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 1.100769e-02 1.958
R-HSA-165159 MTOR signalling 1.199116e-02 1.921
R-HSA-9726840 SHOC2 M1731 mutant abolishes MRAS complex function 1.352728e-02 1.869
R-HSA-72163 mRNA Splicing - Major Pathway 1.345050e-02 1.871
R-HSA-8847453 Synthesis of PIPs in the nucleus 1.352728e-02 1.869
R-HSA-3928662 EPHB-mediated forward signaling 1.365807e-02 1.865
R-HSA-69618 Mitotic Spindle Checkpoint 1.404956e-02 1.852
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 1.452829e-02 1.838
R-HSA-199418 Negative regulation of the PI3K/AKT network 1.459539e-02 1.836
R-HSA-9665686 Signaling by ERBB2 TMD/JMD mutants 1.612099e-02 1.793
R-HSA-9660537 Signaling by MRAS-complex mutants 1.618281e-02 1.791
R-HSA-9726842 Gain-of-function MRAS complexes activate RAF signaling 1.618281e-02 1.791
R-HSA-390696 Adrenoceptors 1.618281e-02 1.791
R-HSA-351906 Apoptotic cleavage of cell adhesion proteins 1.618281e-02 1.791
R-HSA-9620244 Long-term potentiation 1.756452e-02 1.755
R-HSA-72172 mRNA Splicing 1.800133e-02 1.745
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 1.829504e-02 1.738
R-HSA-157858 Gap junction trafficking and regulation 1.844704e-02 1.734
R-HSA-430116 GP1b-IX-V activation signalling 1.904130e-02 1.720
R-HSA-8875555 MET activates RAP1 and RAC1 2.209497e-02 1.656
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 2.173443e-02 1.663
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 2.556921e-02 1.592
R-HSA-141424 Amplification of signal from the kinetochores 2.556921e-02 1.592
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK 2.583163e-02 1.588
R-HSA-8863795 Downregulation of ERBB2 signaling 2.583163e-02 1.588
R-HSA-1250342 PI3K events in ERBB4 signaling 2.875784e-02 1.541
R-HSA-9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters 2.875784e-02 1.541
R-HSA-4420097 VEGFA-VEGFR2 Pathway 2.686059e-02 1.571
R-HSA-111465 Apoptotic cleavage of cellular proteins 2.962839e-02 1.528
R-HSA-186712 Regulation of beta-cell development 3.084001e-02 1.511
R-HSA-2682334 EPH-Ephrin signaling 3.447545e-02 1.462
R-HSA-4641265 Repression of WNT target genes 3.235252e-02 1.490
R-HSA-6804758 Regulation of TP53 Activity through Acetylation 3.163117e-02 1.500
R-HSA-114508 Effects of PIP2 hydrolysis 3.370317e-02 1.472
R-HSA-112043 PLC beta mediated events 3.378591e-02 1.471
R-HSA-5673000 RAF activation 3.584404e-02 1.446
R-HSA-5607763 CLEC7A (Dectin-1) induces NFAT activation 4.003353e-02 1.398
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 3.696702e-02 1.432
R-HSA-6811555 PI5P Regulates TP53 Acetylation 3.611335e-02 1.442
R-HSA-391160 Signal regulatory protein family interactions 4.003353e-02 1.398
R-HSA-9006931 Signaling by Nuclear Receptors 3.839550e-02 1.416
R-HSA-5633007 Regulation of TP53 Activity 3.824970e-02 1.417
R-HSA-194138 Signaling by VEGF 3.762063e-02 1.425
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 3.689031e-02 1.433
R-HSA-8848021 Signaling by PTK6 3.689031e-02 1.433
R-HSA-111933 Calmodulin induced events 4.033067e-02 1.394
R-HSA-111997 CaM pathway 4.033067e-02 1.394
R-HSA-112040 G-protein mediated events 4.357635e-02 1.361
R-HSA-176412 Phosphorylation of the APC/C 4.832579e-02 1.316
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 4.756526e-02 1.323
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 5.010902e-02 1.300
R-HSA-9958790 SLC-mediated transport of inorganic anions 4.508720e-02 1.346
R-HSA-3700989 Transcriptional Regulation by TP53 4.796919e-02 1.319
R-HSA-193704 p75 NTR receptor-mediated signalling 4.509234e-02 1.346
R-HSA-5619109 Defective SLC6A2 causes orthostatic intolerance (OI) 5.100844e-02 1.292
R-HSA-5619050 Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tu... 5.100844e-02 1.292
R-HSA-5619111 Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) 5.100844e-02 1.292
R-HSA-190827 Transport of connexins along the secretory pathway 5.100844e-02 1.292
R-HSA-190704 Oligomerization of connexins into connexons 5.100844e-02 1.292
R-HSA-9931521 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... 5.268519e-02 1.278
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 5.271781e-02 1.278
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 5.275106e-02 1.278
R-HSA-3928664 Ephrin signaling 6.180021e-02 1.209
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 5.479692e-02 1.261
R-HSA-1236394 Signaling by ERBB4 5.680511e-02 1.246
R-HSA-156711 Polo-like kinase mediated events 6.180021e-02 1.209
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 5.479692e-02 1.261
R-HSA-5637810 Constitutive Signaling by EGFRvIII 5.717864e-02 1.243
R-HSA-5637812 Signaling by EGFRvIII in Cancer 5.717864e-02 1.243
R-HSA-8854214 TBC/RABGAPs 6.092701e-02 1.215
R-HSA-111996 Ca-dependent events 5.812756e-02 1.236
R-HSA-1433557 Signaling by SCF-KIT 6.092701e-02 1.215
R-HSA-9831926 Nephron development 6.180021e-02 1.209
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 6.255576e-02 1.204
R-HSA-190828 Gap junction trafficking 6.378843e-02 1.195
R-HSA-68881 Mitotic Metaphase/Anaphase Transition 6.742838e-02 1.171
R-HSA-5619089 Defective SLC6A5 causes hyperekplexia 3 (HKPX3) 6.742838e-02 1.171
R-HSA-9673766 Signaling by cytosolic PDGFRA and PDGFRB fusion proteins 8.356522e-02 1.078
R-HSA-5368598 Negative regulation of TCF-dependent signaling by DVL-interacting proteins 8.356522e-02 1.078
R-HSA-8865999 MET activates PTPN11 8.356522e-02 1.078
R-HSA-165181 Inhibition of TSC complex formation by PKB 9.942380e-02 1.003
R-HSA-74713 IRS activation 1.150089e-01 0.939
R-HSA-9673768 Signaling by membrane-tethered fusions of PDGFRA or PDGFRB 1.150089e-01 0.939
R-HSA-9706377 FLT3 signaling by CBL mutants 1.150089e-01 0.939
R-HSA-9652817 Signaling by MAPK mutants 1.303253e-01 0.885
R-HSA-9645135 STAT5 Activation 1.453775e-01 0.838
R-HSA-8851907 MET activates PI3K/AKT signaling 1.601701e-01 0.795
R-HSA-9732724 IFNG signaling activates MAPKs 1.601701e-01 0.795
R-HSA-964827 Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 t... 1.601701e-01 0.795
R-HSA-112412 SOS-mediated signalling 1.601701e-01 0.795
R-HSA-8875656 MET receptor recycling 1.747075e-01 0.758
R-HSA-9028335 Activated NTRK2 signals through PI3K 1.747075e-01 0.758
R-HSA-170984 ARMS-mediated activation 1.889942e-01 0.724
R-HSA-201688 WNT mediated activation of DVL 1.889942e-01 0.724
R-HSA-390450 Folding of actin by CCT/TriC 2.030344e-01 0.692
R-HSA-6803529 FGFR2 alternative splicing 8.663451e-02 1.062
R-HSA-163765 ChREBP activates metabolic gene expression 2.168324e-01 0.664
R-HSA-429947 Deadenylation of mRNA 9.727605e-02 1.012
R-HSA-9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... 1.082635e-01 0.966
R-HSA-9820865 Z-decay: degradation of maternal mRNAs by zygotically expressed factors 2.437184e-01 0.613
R-HSA-9619483 Activation of AMPK downstream of NMDARs 1.195608e-01 0.922
R-HSA-69166 Removal of the Flap Intermediate 2.696845e-01 0.569
R-HSA-159227 Transport of the SLBP independent Mature mRNA 1.489414e-01 0.827
R-HSA-72187 mRNA 3'-end processing 8.880565e-02 1.052
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 1.549816e-01 0.810
R-HSA-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins 2.947622e-01 0.531
R-HSA-9687136 Aberrant regulation of mitotic exit in cancer due to RB1 defects 2.947622e-01 0.531
R-HSA-77595 Processing of Intronless Pre-mRNAs 3.069774e-01 0.513
R-HSA-174437 Removal of the Flap Intermediate from the C-strand 3.189817e-01 0.496
R-HSA-372708 p130Cas linkage to MAPK signaling for integrins 3.189817e-01 0.496
R-HSA-190840 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 3.189817e-01 0.496
R-HSA-180292 GAB1 signalosome 3.307788e-01 0.480
R-HSA-5651801 PCNA-Dependent Long Patch Base Excision Repair 3.307788e-01 0.480
R-HSA-5654710 PI-3K cascade:FGFR3 3.423723e-01 0.466
R-HSA-912631 Regulation of signaling by CBL 3.423723e-01 0.466
R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B 3.423723e-01 0.466
R-HSA-167242 Abortive elongation of HIV-1 transcript in the absence of Tat 3.423723e-01 0.466
R-HSA-5654720 PI-3K cascade:FGFR4 3.537657e-01 0.451
R-HSA-9934037 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 3.537657e-01 0.451
R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A 3.649623e-01 0.438
R-HSA-5602498 MyD88 deficiency (TLR2/4) 3.649623e-01 0.438
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 1.694046e-01 0.771
R-HSA-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER 3.759657e-01 0.425
R-HSA-5603041 IRAK4 deficiency (TLR2/4) 3.759657e-01 0.425
R-HSA-380287 Centrosome maturation 1.779550e-01 0.750
R-HSA-5654689 PI-3K cascade:FGFR1 3.867790e-01 0.413
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... 2.879833e-01 0.541
R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 3.072058e-01 0.513
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 2.405959e-01 0.619
R-HSA-191859 snRNP Assembly 3.263268e-01 0.486
R-HSA-194441 Metabolism of non-coding RNA 3.263268e-01 0.486
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 3.515959e-01 0.454
R-HSA-380259 Loss of Nlp from mitotic centrosomes 3.515959e-01 0.454
R-HSA-8854518 AURKA Activation by TPX2 3.703337e-01 0.431
R-HSA-182971 EGFR downregulation 1.370139e-01 0.863
R-HSA-69183 Processive synthesis on the lagging strand 2.823325e-01 0.549
R-HSA-2871809 FCERI mediated Ca+2 mobilization 1.901759e-01 0.721
R-HSA-198203 PI3K/AKT activation 2.030344e-01 0.692
R-HSA-3371568 Attenuation phase 1.983760e-01 0.703
R-HSA-5620916 VxPx cargo-targeting to cilium 3.537657e-01 0.451
R-HSA-9931529 Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK 1.150089e-01 0.939
R-HSA-163680 AMPK inhibits chREBP transcriptional activation activity 1.889942e-01 0.724
R-HSA-3371571 HSF1-dependent transactivation 8.548048e-02 1.068
R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 2.751335e-01 0.560
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 8.956071e-02 1.048
R-HSA-2025928 Calcineurin activates NFAT 1.889942e-01 0.724
R-HSA-9664420 Killing mechanisms 2.947622e-01 0.531
R-HSA-9673324 WNT5:FZD7-mediated leishmania damping 2.947622e-01 0.531
R-HSA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 3.189817e-01 0.496
R-HSA-190872 Transport of connexons to the plasma membrane 3.307788e-01 0.480
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 2.177481e-01 0.662
R-HSA-177929 Signaling by EGFR 1.026326e-01 0.989
R-HSA-69186 Lagging Strand Synthesis 3.649623e-01 0.438
R-HSA-9613829 Chaperone Mediated Autophagy 3.307788e-01 0.480
R-HSA-8875360 InlB-mediated entry of Listeria monocytogenes into host cell 2.823325e-01 0.549
R-HSA-2467813 Separation of Sister Chromatids 1.015153e-01 0.993
R-HSA-8937144 Aryl hydrocarbon receptor signalling 1.303253e-01 0.885
R-HSA-9613354 Lipophagy 1.889942e-01 0.724
R-HSA-964739 N-glycan trimming and elongation in the cis-Golgi 2.696845e-01 0.569
R-HSA-202433 Generation of second messenger molecules 1.983760e-01 0.703
R-HSA-9027276 Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 2.437184e-01 0.613
R-HSA-3371511 HSF1 activation 1.733664e-01 0.761
R-HSA-68877 Mitotic Prometaphase 1.685945e-01 0.773
R-HSA-3928665 EPH-ephrin mediated repulsion of cells 7.273608e-02 1.138
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 1.943031e-01 0.712
R-HSA-176417 Phosphorylation of Emi1 1.303253e-01 0.885
R-HSA-446107 Type I hemidesmosome assembly 1.747075e-01 0.758
R-HSA-2151209 Activation of PPARGC1A (PGC-1alpha) by phosphorylation 2.030344e-01 0.692
R-HSA-68884 Mitotic Telophase/Cytokinesis 2.303924e-01 0.638
R-HSA-202670 ERKs are inactivated 2.303924e-01 0.638
R-HSA-445095 Interaction between L1 and Ankyrins 1.138756e-01 0.944
R-HSA-162658 Golgi Cisternae Pericentriolar Stack Reorganization 2.568144e-01 0.590
R-HSA-9933947 Formation of the non-canonical BAF (ncBAF) complex 2.568144e-01 0.590
R-HSA-9680350 Signaling by CSF1 (M-CSF) in myeloid cells 1.610681e-01 0.793
R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex 3.069774e-01 0.513
R-HSA-429914 Deadenylation-dependent mRNA decay 1.135264e-01 0.945
R-HSA-2428928 IRS-related events triggered by IGF1R 1.210224e-01 0.917
R-HSA-73856 RNA Polymerase II Transcription Termination 1.210224e-01 0.917
R-HSA-181429 Serotonin Neurotransmitter Release Cycle 3.307788e-01 0.480
R-HSA-8851708 Signaling by FGFR2 IIIa TM 3.423723e-01 0.466
R-HSA-168325 Viral Messenger RNA Synthesis 3.389981e-01 0.470
R-HSA-8856828 Clathrin-mediated endocytosis 1.528641e-01 0.816
R-HSA-1234174 Cellular response to hypoxia 3.641105e-01 0.439
R-HSA-3371556 Cellular response to heat stress 2.115224e-01 0.675
R-HSA-112399 IRS-mediated signalling 1.062158e-01 0.974
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 8.518523e-02 1.070
R-HSA-74749 Signal attenuation 2.030344e-01 0.692
R-HSA-202403 TCR signaling 3.583029e-01 0.446
R-HSA-8875878 MET promotes cell motility 1.858105e-01 0.731
R-HSA-6807004 Negative regulation of MET activity 3.537657e-01 0.451
R-HSA-9603381 Activated NTRK3 signals through PI3K 1.601701e-01 0.795
R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation 1.082635e-01 0.966
R-HSA-74751 Insulin receptor signalling cascade 1.325950e-01 0.877
R-HSA-212676 Dopamine Neurotransmitter Release Cycle 3.867790e-01 0.413
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 3.949747e-01 0.403
R-HSA-8876384 Listeria monocytogenes entry into host cells 3.759657e-01 0.425
R-HSA-201681 TCF dependent signaling in response to WNT 2.786982e-01 0.555
R-HSA-166208 mTORC1-mediated signalling 8.663451e-02 1.062
R-HSA-9856532 Mechanical load activates signaling by PIEZO1 and integrins in osteocytes 3.423723e-01 0.466
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 2.873038e-01 0.542
R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants 3.307788e-01 0.480
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 3.453068e-01 0.462
R-HSA-2428924 IGF1R signaling cascade 1.325950e-01 0.877
R-HSA-6806834 Signaling by MET 1.998205e-01 0.699
R-HSA-5654738 Signaling by FGFR2 6.966974e-02 1.157
R-HSA-5674499 Negative feedback regulation of MAPK pathway 1.303253e-01 0.885
R-HSA-8964046 VLDL clearance 1.601701e-01 0.795
R-HSA-428359 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... 2.030344e-01 0.692
R-HSA-9706019 RHOBTB3 ATPase cycle 2.168324e-01 0.664
R-HSA-399954 Sema3A PAK dependent Axon repulsion 2.823325e-01 0.549
R-HSA-388844 Receptor-type tyrosine-protein phosphatases 2.947622e-01 0.531
R-HSA-430039 mRNA decay by 5' to 3' exoribonuclease 3.069774e-01 0.513
R-HSA-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anapha... 3.069774e-01 0.513
R-HSA-168276 NS1 Mediated Effects on Host Pathways 1.920796e-01 0.717
R-HSA-264642 Acetylcholine Neurotransmitter Release Cycle 3.649623e-01 0.438
R-HSA-9639288 Amino acids regulate mTORC1 2.879833e-01 0.541
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 3.688076e-01 0.433
R-HSA-74752 Signaling by Insulin receptor 1.048876e-01 0.979
R-HSA-8953854 Metabolism of RNA 7.475370e-02 1.126
R-HSA-69275 G2/M Transition 7.014826e-02 1.154
R-HSA-169893 Prolonged ERK activation events 2.947622e-01 0.531
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 1.365358e-01 0.865
R-HSA-453274 Mitotic G2-G2/M phases 7.299721e-02 1.137
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 1.098474e-01 0.959
R-HSA-2555396 Mitotic Metaphase and Anaphase 1.237453e-01 0.907
R-HSA-9842663 Signaling by LTK 2.437184e-01 0.613
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 1.920796e-01 0.717
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 3.453068e-01 0.462
R-HSA-5654743 Signaling by FGFR4 2.237812e-01 0.650
R-HSA-8934903 Receptor Mediated Mitophagy 2.030344e-01 0.692
R-HSA-9702518 STAT5 activation downstream of FLT3 ITD mutants 3.069774e-01 0.513
R-HSA-983189 Kinesins 3.326710e-01 0.478
R-HSA-190236 Signaling by FGFR 1.250117e-01 0.903
R-HSA-68882 Mitotic Anaphase 1.218182e-01 0.914
R-HSA-5654741 Signaling by FGFR3 2.365794e-01 0.626
R-HSA-163685 Integration of energy metabolism 2.789289e-01 0.555
R-HSA-1295596 Spry regulation of FGF signaling 2.823325e-01 0.549
R-HSA-9682385 FLT3 signaling in disease 1.733664e-01 0.761
R-HSA-195721 Signaling by WNT 3.209848e-01 0.494
R-HSA-69278 Cell Cycle, Mitotic 2.287703e-01 0.641
R-HSA-3214847 HATs acetylate histones 3.014757e-01 0.521
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling 2.174023e-01 0.663
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 2.491585e-01 0.604
R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 7.637706e-02 1.117
R-HSA-5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer 7.637706e-02 1.117
R-HSA-199991 Membrane Trafficking 8.013003e-02 1.096
R-HSA-1640170 Cell Cycle 2.937361e-01 0.532
R-HSA-9612973 Autophagy 1.899834e-01 0.721
R-HSA-9607240 FLT3 Signaling 2.046971e-01 0.689
R-HSA-427652 Sodium-coupled phosphate cotransporters 1.303253e-01 0.885
R-HSA-2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7 1.453775e-01 0.838
R-HSA-426117 Cation-coupled Chloride cotransporters 1.601701e-01 0.795
R-HSA-428890 Role of ABL in ROBO-SLIT signaling 1.601701e-01 0.795
R-HSA-8849469 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 1.747075e-01 0.758
R-HSA-425986 Sodium/Proton exchangers 1.747075e-01 0.758
R-HSA-9820962 Assembly and release of respiratory syncytial virus (RSV) virions 2.030344e-01 0.692
R-HSA-425381 Bicarbonate transporters 2.168324e-01 0.664
R-HSA-69109 Leading Strand Synthesis 2.437184e-01 0.613
R-HSA-69091 Polymerase switching 2.437184e-01 0.613
R-HSA-9942503 Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) 2.947622e-01 0.531
R-HSA-9945266 Differentiation of T cells 2.947622e-01 0.531
R-HSA-9706369 Negative regulation of FLT3 2.947622e-01 0.531
R-HSA-375280 Amine ligand-binding receptors 2.301744e-01 0.638
R-HSA-5654736 Signaling by FGFR1 3.072058e-01 0.513
R-HSA-1643713 Signaling by EGFR in Cancer 1.082635e-01 0.966
R-HSA-2980766 Nuclear Envelope Breakdown 3.135928e-01 0.504
R-HSA-5655302 Signaling by FGFR1 in disease 2.110401e-01 0.676
R-HSA-3214841 PKMTs methylate histone lysines 2.046971e-01 0.689
R-HSA-5653656 Vesicle-mediated transport 2.819009e-01 0.550
R-HSA-5693548 Sensing of DNA Double Strand Breaks 2.303924e-01 0.638
R-HSA-844456 The NLRP3 inflammasome 3.423723e-01 0.466
R-HSA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation 6.671100e-02 1.176
R-HSA-195253 Degradation of beta-catenin by the destruction complex 3.949747e-01 0.403
R-HSA-422475 Axon guidance 1.933715e-01 0.714
R-HSA-437239 Recycling pathway of L1 2.494157e-01 0.603
R-HSA-76002 Platelet activation, signaling and aggregation 2.559039e-01 0.592
R-HSA-5628897 TP53 Regulates Metabolic Genes 1.866876e-01 0.729
R-HSA-9758919 Epithelial-Mesenchymal Transition (EMT) during gastrulation 1.303253e-01 0.885
R-HSA-5336415 Uptake and function of diphtheria toxin 1.601701e-01 0.795
R-HSA-9834752 Respiratory syncytial virus genome replication 1.889942e-01 0.724
R-HSA-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 2.568144e-01 0.590
R-HSA-5655291 Signaling by FGFR4 in disease 2.696845e-01 0.569
R-HSA-9933937 Formation of the canonical BAF (cBAF) complex 2.696845e-01 0.569
R-HSA-9933946 Formation of the embryonic stem cell BAF (esBAF) complex 2.823325e-01 0.549
R-HSA-139853 Elevation of cytosolic Ca2+ levels 3.189817e-01 0.496
R-HSA-9665348 Signaling by ERBB2 ECD mutants 3.307788e-01 0.480
R-HSA-9675108 Nervous system development 2.573994e-01 0.589
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 2.314052e-01 0.636
R-HSA-69620 Cell Cycle Checkpoints 2.149652e-01 0.668
R-HSA-9764561 Regulation of CDH1 Function 3.135928e-01 0.504
R-HSA-1632852 Macroautophagy 2.982714e-01 0.525
R-HSA-9913351 Formation of the dystrophin-glycoprotein complex (DGC) 1.370139e-01 0.863
R-HSA-1226099 Signaling by FGFR in disease 1.736647e-01 0.760
R-HSA-6794362 Protein-protein interactions at synapses 2.222819e-01 0.653
R-HSA-9671555 Signaling by PDGFR in disease 8.145530e-02 1.089
R-HSA-1247673 Erythrocytes take up oxygen and release carbon dioxide 2.437184e-01 0.613
R-HSA-9933939 Formation of the polybromo-BAF (pBAF) complex 2.696845e-01 0.569
R-HSA-109704 PI3K Cascade 8.220996e-02 1.085
R-HSA-8853659 RET signaling 1.733664e-01 0.761
R-HSA-9845576 Glycosphingolipid transport 1.733664e-01 0.761
R-HSA-947581 Molybdenum cofactor biosynthesis 3.759657e-01 0.425
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 3.361125e-01 0.474
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 2.524012e-01 0.598
R-HSA-6794361 Neurexins and neuroligins 2.815607e-01 0.550
R-HSA-112315 Transmission across Chemical Synapses 1.490203e-01 0.827
R-HSA-9659379 Sensory processing of sound 1.953956e-01 0.709
R-HSA-1280218 Adaptive Immune System 2.390934e-01 0.621
R-HSA-112316 Neuronal System 1.508835e-01 0.821
R-HSA-1480926 O2/CO2 exchange in erythrocytes 3.423723e-01 0.466
R-HSA-392517 Rap1 signalling 3.423723e-01 0.466
R-HSA-442660 SLC-mediated transport of neurotransmitters 2.110401e-01 0.676
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse 3.537657e-01 0.451
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 1.485928e-01 0.828
R-HSA-198753 ERK/MAPK targets 3.649623e-01 0.438
R-HSA-5655253 Signaling by FGFR2 in disease 2.687035e-01 0.571
R-HSA-140875 Common Pathway of Fibrin Clot Formation 3.537657e-01 0.451
R-HSA-9855142 Cellular responses to mechanical stimuli 3.771517e-01 0.423
R-HSA-1433559 Regulation of KIT signaling 2.696845e-01 0.569
R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea 1.026326e-01 0.989
R-HSA-8849932 Synaptic adhesion-like molecules 3.307788e-01 0.480
R-HSA-1237044 Erythrocytes take up carbon dioxide and release oxygen 3.423723e-01 0.466
R-HSA-1169408 ISG15 antiviral mechanism 1.779550e-01 0.750
R-HSA-71384 Ethanol oxidation 3.867790e-01 0.413
R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins 2.815607e-01 0.550
R-HSA-5685942 HDR through Homologous Recombination (HRR) 3.765327e-01 0.424
R-HSA-9707616 Heme signaling 3.453068e-01 0.462
R-HSA-451927 Interleukin-2 family signaling 1.983760e-01 0.703
R-HSA-111885 Opioid Signalling 1.434537e-01 0.843
R-HSA-8983432 Interleukin-15 signaling 2.437184e-01 0.613
R-HSA-373752 Netrin-1 signaling 2.301744e-01 0.638
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer 9.190971e-02 1.037
R-HSA-198323 AKT phosphorylates targets in the cytosol 2.437184e-01 0.613
R-HSA-5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 3.189817e-01 0.496
R-HSA-5607764 CLEC7A (Dectin-1) signaling 2.873038e-01 0.542
R-HSA-2586552 Signaling by Leptin 2.030344e-01 0.692
R-HSA-9020558 Interleukin-2 signaling 2.168324e-01 0.664
R-HSA-9034015 Signaling by NTRK3 (TRKC) 3.759657e-01 0.425
R-HSA-9705683 SARS-CoV-2-host interactions 2.670640e-01 0.573
R-HSA-9825892 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 8.145530e-02 1.089
R-HSA-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 3.189817e-01 0.496
R-HSA-983169 Class I MHC mediated antigen processing & presentation 1.720328e-01 0.764
R-HSA-166520 Signaling by NTRKs 3.295226e-01 0.482
R-HSA-418885 DCC mediated attractive signaling 2.823325e-01 0.549
R-HSA-112409 RAF-independent MAPK1/3 activation 3.867790e-01 0.413
R-HSA-1257604 PIP3 activates AKT signaling 1.032726e-01 0.986
R-HSA-5619102 SLC transporter disorders 2.236375e-01 0.650
R-HSA-373755 Semaphorin interactions 3.515959e-01 0.454
R-HSA-9764790 Positive Regulation of CDH1 Gene Transcription 2.030344e-01 0.692
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in ... 3.867790e-01 0.413
R-HSA-1500931 Cell-Cell communication 3.715059e-01 0.430
R-HSA-8983711 OAS antiviral response 2.437184e-01 0.613
R-HSA-9856651 MITF-M-dependent gene expression 1.724589e-01 0.763
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 3.453068e-01 0.462
R-HSA-5358508 Mismatch Repair 3.307788e-01 0.480
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 1.489414e-01 0.827
R-HSA-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... 3.069774e-01 0.513
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 2.622725e-01 0.581
R-HSA-9730414 MITF-M-regulated melanocyte development 2.241627e-01 0.649
R-HSA-75153 Apoptotic execution phase 6.969384e-02 1.157
R-HSA-1059683 Interleukin-6 signaling 2.568144e-01 0.590
R-HSA-8964038 LDL clearance 3.867790e-01 0.413
R-HSA-9841251 Mitochondrial unfolded protein response (UPRmt) 1.138756e-01 0.944
R-HSA-9682706 Replication of the SARS-CoV-1 genome 2.568144e-01 0.590
R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 3.515959e-01 0.454
R-HSA-9694686 Replication of the SARS-CoV-2 genome 3.189817e-01 0.496
R-HSA-9694516 SARS-CoV-2 Infection 3.174014e-01 0.498
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 3.530877e-01 0.452
R-HSA-9830369 Kidney development 3.765327e-01 0.424
R-HSA-9679514 SARS-CoV-1 Genome Replication and Transcription 2.696845e-01 0.569
R-HSA-9694682 SARS-CoV-2 Genome Replication and Transcription 3.423723e-01 0.466
R-HSA-2028269 Signaling by Hippo 3.189817e-01 0.496
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... 3.641105e-01 0.439
R-HSA-73887 Death Receptor Signaling 8.297781e-02 1.081
R-HSA-77075 RNA Pol II CTD phosphorylation and interaction with CE 3.974056e-01 0.401
R-HSA-167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 3.974056e-01 0.401
R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC 3.974056e-01 0.401
R-HSA-912526 Interleukin receptor SHC signaling 3.974056e-01 0.401
R-HSA-200425 Carnitine shuttle 3.974056e-01 0.401
R-HSA-982772 Growth hormone receptor signaling 3.974056e-01 0.401
R-HSA-9007101 Rab regulation of trafficking 4.005473e-01 0.397
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 4.010672e-01 0.397
R-HSA-453276 Regulation of mitotic cell cycle 4.010672e-01 0.397
R-HSA-68886 M Phase 4.061698e-01 0.391
R-HSA-75067 Processing of Capped Intronless Pre-mRNA 4.078488e-01 0.390
R-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex 4.078488e-01 0.390
R-HSA-9703648 Signaling by FLT3 ITD and TKD mutants 4.078488e-01 0.390
R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle 4.078488e-01 0.390
R-HSA-5621575 CD209 (DC-SIGN) signaling 4.078488e-01 0.390
R-HSA-446199 Synthesis of dolichyl-phosphate 4.078488e-01 0.390
R-HSA-6783589 Interleukin-6 family signaling 4.078488e-01 0.390
R-HSA-4086398 Ca2+ pathway 4.131647e-01 0.384
R-HSA-5654695 PI-3K cascade:FGFR2 4.181115e-01 0.379
R-HSA-9932444 ATP-dependent chromatin remodelers 4.181115e-01 0.379
R-HSA-9932451 SWI/SNF chromatin remodelers 4.181115e-01 0.379
R-HSA-1482801 Acyl chain remodelling of PS 4.181115e-01 0.379
R-HSA-5218921 VEGFR2 mediated cell proliferation 4.181115e-01 0.379
R-HSA-174411 Polymerase switching on the C-strand of the telomere 4.181115e-01 0.379
R-HSA-400685 Sema4D in semaphorin signaling 4.181115e-01 0.379
R-HSA-1266695 Interleukin-7 signaling 4.181115e-01 0.379
R-HSA-5621481 C-type lectin receptors (CLRs) 4.235023e-01 0.373
R-HSA-8852135 Protein ubiquitination 4.251402e-01 0.371
R-HSA-3000171 Non-integrin membrane-ECM interactions 4.251402e-01 0.371
R-HSA-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway 4.281970e-01 0.368
R-HSA-210500 Glutamate Neurotransmitter Release Cycle 4.281970e-01 0.368
R-HSA-9703465 Signaling by FLT3 fusion proteins 4.281970e-01 0.368
R-HSA-525793 Myogenesis 4.281970e-01 0.368
R-HSA-9816359 Maternal to zygotic transition (MZT) 4.282886e-01 0.368
R-HSA-8878171 Transcriptional regulation by RUNX1 4.285922e-01 0.368
R-HSA-1980143 Signaling by NOTCH1 4.310804e-01 0.365
R-HSA-9020591 Interleukin-12 signaling 4.310804e-01 0.365
R-HSA-174414 Processive synthesis on the C-strand of the telomere 4.381084e-01 0.358
R-HSA-167243 Tat-mediated HIV elongation arrest and recovery 4.381084e-01 0.358
R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation 4.381084e-01 0.358
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane 4.381084e-01 0.358
R-HSA-5655332 Signaling by FGFR3 in disease 4.381084e-01 0.358
R-HSA-1483213 Synthesis of PE 4.381084e-01 0.358
R-HSA-389357 CD28 dependent PI3K/Akt signaling 4.381084e-01 0.358
R-HSA-264876 Insulin processing 4.381084e-01 0.358
R-HSA-9006115 Signaling by NTRK2 (TRKB) 4.381084e-01 0.358
R-HSA-167158 Formation of the HIV-1 Early Elongation Complex 4.478485e-01 0.349
R-HSA-113418 Formation of the Early Elongation Complex 4.478485e-01 0.349
R-HSA-167287 HIV elongation arrest and recovery 4.478485e-01 0.349
R-HSA-167290 Pausing and recovery of HIV elongation 4.478485e-01 0.349
R-HSA-5654732 Negative regulation of FGFR3 signaling 4.478485e-01 0.349
R-HSA-77387 Insulin receptor recycling 4.478485e-01 0.349
R-HSA-622312 Inflammasomes 4.478485e-01 0.349
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 4.487024e-01 0.348
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 4.545082e-01 0.342
R-HSA-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... 4.545082e-01 0.342
R-HSA-187037 Signaling by NTRK1 (TRKA) 4.555665e-01 0.341
R-HSA-3247509 Chromatin modifying enzymes 4.556637e-01 0.341
R-HSA-72086 mRNA Capping 4.574204e-01 0.340
R-HSA-5654733 Negative regulation of FGFR4 signaling 4.574204e-01 0.340
R-HSA-5654708 Downstream signaling of activated FGFR3 4.574204e-01 0.340
R-HSA-5656169 Termination of translesion DNA synthesis 4.574204e-01 0.340
R-HSA-9006335 Signaling by Erythropoietin 4.574204e-01 0.340
R-HSA-418360 Platelet calcium homeostasis 4.574204e-01 0.340
R-HSA-9674555 Signaling by CSF3 (G-CSF) 4.574204e-01 0.340
R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases 4.574204e-01 0.340
R-HSA-977225 Amyloid fiber formation 4.602789e-01 0.337
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 4.668269e-01 0.331
R-HSA-2424491 DAP12 signaling 4.668269e-01 0.331
R-HSA-9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects 4.668269e-01 0.331
R-HSA-5654716 Downstream signaling of activated FGFR4 4.668269e-01 0.331
R-HSA-888590 GABA synthesis, release, reuptake and degradation 4.668269e-01 0.331
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 4.760709e-01 0.322
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 4.760709e-01 0.322
R-HSA-389958 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 4.760709e-01 0.322
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 4.773756e-01 0.321
R-HSA-9909396 Circadian clock 4.778775e-01 0.321
R-HSA-8856688 Golgi-to-ER retrograde transport 4.778775e-01 0.321
R-HSA-69190 DNA strand elongation 4.851553e-01 0.314
R-HSA-9937080 Developmental Lineage of Multipotent Pancreatic Progenitor Cells 4.851553e-01 0.314
R-HSA-9675126 Diseases of mitotic cell cycle 4.851553e-01 0.314
R-HSA-1855170 IPs transport between nucleus and cytosol 4.940826e-01 0.306
R-HSA-354192 Integrin signaling 4.940826e-01 0.306
R-HSA-5654726 Negative regulation of FGFR1 signaling 4.940826e-01 0.306
R-HSA-176187 Activation of ATR in response to replication stress 4.940826e-01 0.306
R-HSA-1839124 FGFR1 mutant receptor activation 4.940826e-01 0.306
R-HSA-9930044 Nuclear RNA decay 4.940826e-01 0.306
R-HSA-5619115 Disorders of transmembrane transporters 4.988477e-01 0.302
R-HSA-390466 Chaperonin-mediated protein folding 4.996516e-01 0.301
R-HSA-447115 Interleukin-12 family signaling 4.996516e-01 0.301
R-HSA-3858494 Beta-catenin independent WNT signaling 4.997568e-01 0.301
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis 5.028557e-01 0.299
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 5.028557e-01 0.299
R-HSA-1482788 Acyl chain remodelling of PC 5.028557e-01 0.299
R-HSA-5696394 DNA Damage Recognition in GG-NER 5.028557e-01 0.299
R-HSA-9663891 Selective autophagy 5.051252e-01 0.297
R-HSA-4839726 Chromatin organization 5.053809e-01 0.296
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian expression 5.114772e-01 0.291
R-HSA-5696400 Dual Incision in GG-NER 5.114772e-01 0.291
R-HSA-190861 Gap junction assembly 5.114772e-01 0.291
R-HSA-5654727 Negative regulation of FGFR2 signaling 5.114772e-01 0.291
R-HSA-180746 Nuclear import of Rev protein 5.114772e-01 0.291
R-HSA-5205647 Mitophagy 5.114772e-01 0.291
R-HSA-5686938 Regulation of TLR by endogenous ligand 5.114772e-01 0.291
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 5.159555e-01 0.287
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 5.199497e-01 0.284
R-HSA-5654696 Downstream signaling of activated FGFR2 5.199497e-01 0.284
R-HSA-5654687 Downstream signaling of activated FGFR1 5.199497e-01 0.284
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 5.199497e-01 0.284
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 5.199497e-01 0.284
R-HSA-1482839 Acyl chain remodelling of PE 5.199497e-01 0.284
R-HSA-2559585 Oncogene Induced Senescence 5.199497e-01 0.284
R-HSA-187687 Signalling to ERKs 5.199497e-01 0.284
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 5.211649e-01 0.283
R-HSA-388396 GPCR downstream signalling 5.243889e-01 0.280
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA 5.282758e-01 0.277
R-HSA-140877 Formation of Fibrin Clot (Clotting Cascade) 5.282758e-01 0.277
R-HSA-1839126 FGFR2 mutant receptor activation 5.282758e-01 0.277
R-HSA-114604 GPVI-mediated activation cascade 5.282758e-01 0.277
R-HSA-6804757 Regulation of TP53 Degradation 5.282758e-01 0.277
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 5.295884e-01 0.276
R-HSA-391251 Protein folding 5.319049e-01 0.274
R-HSA-4641258 Degradation of DVL 5.364579e-01 0.270
R-HSA-180910 Vpr-mediated nuclear import of PICs 5.364579e-01 0.270
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... 5.371413e-01 0.270
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 5.444987e-01 0.264
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange 5.444987e-01 0.264
R-HSA-452723 Transcriptional regulation of pluripotent stem cells 5.444987e-01 0.264
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat 5.524004e-01 0.258
R-HSA-8953750 Transcriptional Regulation by E2F6 5.524004e-01 0.258
R-HSA-8964043 Plasma lipoprotein clearance 5.524004e-01 0.258
R-HSA-201556 Signaling by ALK 5.524004e-01 0.258
R-HSA-6806003 Regulation of TP53 Expression and Degradation 5.524004e-01 0.258
R-HSA-9820965 Respiratory syncytial virus (RSV) genome replication, transcription and translat... 5.524004e-01 0.258
R-HSA-913531 Interferon Signaling 5.596686e-01 0.252
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat 5.601656e-01 0.252
R-HSA-167169 HIV Transcription Elongation 5.601656e-01 0.252
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript 5.601656e-01 0.252
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 5.601656e-01 0.252
R-HSA-177243 Interactions of Rev with host cellular proteins 5.601656e-01 0.252
R-HSA-176033 Interactions of Vpr with host cellular proteins 5.601656e-01 0.252
R-HSA-5602358 Diseases associated with the TLR signaling cascade 5.601656e-01 0.252
R-HSA-5260271 Diseases of Immune System 5.601656e-01 0.252
R-HSA-422356 Regulation of insulin secretion 5.677081e-01 0.246
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 5.677965e-01 0.246
R-HSA-73933 Resolution of Abasic Sites (AP sites) 5.677965e-01 0.246
R-HSA-9694548 Maturation of spike protein 5.677965e-01 0.246
R-HSA-8853884 Transcriptional Regulation by VENTX 5.677965e-01 0.246
R-HSA-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... 5.677965e-01 0.246
R-HSA-5218920 VEGFR2 mediated vascular permeability 5.677965e-01 0.246
R-HSA-5693532 DNA Double-Strand Break Repair 5.743942e-01 0.241
R-HSA-167162 RNA Polymerase II HIV Promoter Escape 5.752955e-01 0.240
R-HSA-167161 HIV Transcription Initiation 5.752955e-01 0.240
R-HSA-75953 RNA Polymerase II Transcription Initiation 5.752955e-01 0.240
R-HSA-174417 Telomere C-strand (Lagging Strand) Synthesis 5.752955e-01 0.240
R-HSA-6811438 Intra-Golgi traffic 5.752955e-01 0.240
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 5.826648e-01 0.235
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 5.872655e-01 0.231
R-HSA-1483255 PI Metabolism 5.872655e-01 0.231
R-HSA-73776 RNA Polymerase II Promoter Escape 5.899067e-01 0.229
R-HSA-2173789 TGF-beta receptor signaling activates SMADs 5.899067e-01 0.229
R-HSA-446728 Cell junction organization 5.957827e-01 0.225
R-HSA-9860931 Response of endothelial cells to shear stress 5.967964e-01 0.224
R-HSA-2172127 DAP12 interactions 5.970234e-01 0.224
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 5.970234e-01 0.224
R-HSA-877300 Interferon gamma signaling 5.976893e-01 0.224
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance 6.040170e-01 0.219
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere 6.040170e-01 0.219
R-HSA-774815 Nucleosome assembly 6.040170e-01 0.219
R-HSA-76009 Platelet Aggregation (Plug Formation) 6.040170e-01 0.219
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 6.040170e-01 0.219
R-HSA-69613 p53-Independent G1/S DNA Damage Checkpoint 6.040170e-01 0.219
R-HSA-69601 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A 6.040170e-01 0.219
R-HSA-9824443 Parasitic Infection Pathways 6.046050e-01 0.219
R-HSA-9658195 Leishmania infection 6.046050e-01 0.219
R-HSA-5696398 Nucleotide Excision Repair 6.061619e-01 0.217
R-HSA-109581 Apoptosis 6.090216e-01 0.215
R-HSA-72165 mRNA Splicing - Minor Pathway 6.108897e-01 0.214
R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C 6.108897e-01 0.214
R-HSA-2299718 Condensation of Prophase Chromosomes 6.108897e-01 0.214
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 6.108897e-01 0.214
R-HSA-9664424 Cell recruitment (pro-inflammatory response) 6.108897e-01 0.214
R-HSA-9660826 Purinergic signaling in leishmaniasis infection 6.108897e-01 0.214
R-HSA-5357905 Regulation of TNFR1 signaling 6.108897e-01 0.214
R-HSA-69239 Synthesis of DNA 6.153620e-01 0.211
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin 6.176435e-01 0.209
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network 6.176435e-01 0.209
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 6.199002e-01 0.208
R-HSA-389356 Co-stimulation by CD28 6.242805e-01 0.205
R-HSA-425410 Metal ion SLC transporters 6.242805e-01 0.205
R-HSA-73893 DNA Damage Bypass 6.308026e-01 0.200
R-HSA-5658442 Regulation of RAS by GAPs 6.372120e-01 0.196
R-HSA-1169091 Activation of NF-kappaB in B cells 6.435105e-01 0.191
R-HSA-9864848 Complex IV assembly 6.435105e-01 0.191
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 6.462663e-01 0.190
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 6.497000e-01 0.187
R-HSA-112382 Formation of RNA Pol II elongation complex 6.497000e-01 0.187
R-HSA-9931269 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) 6.497000e-01 0.187
R-HSA-9692916 SARS-CoV-1 activates/modulates innate immune responses 6.497000e-01 0.187
R-HSA-5339562 Uptake and actions of bacterial toxins 6.497000e-01 0.187
R-HSA-109582 Hemostasis 6.513454e-01 0.186
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 6.521952e-01 0.186
R-HSA-9764265 Regulation of CDH1 Expression and Function 6.521952e-01 0.186
R-HSA-75955 RNA Polymerase II Transcription Elongation 6.557824e-01 0.183
R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... 6.557824e-01 0.183
R-HSA-432722 Golgi Associated Vesicle Biogenesis 6.557824e-01 0.183
R-HSA-5250924 B-WICH complex positively regulates rRNA expression 6.557824e-01 0.183
R-HSA-445355 Smooth Muscle Contraction 6.557824e-01 0.183
R-HSA-1221632 Meiotic synapsis 6.557824e-01 0.183
R-HSA-2029485 Role of phospholipids in phagocytosis 6.588987e-01 0.181
R-HSA-72649 Translation initiation complex formation 6.617596e-01 0.179
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 6.617596e-01 0.179
R-HSA-9754678 SARS-CoV-2 modulates host translation machinery 6.617596e-01 0.179
R-HSA-72737 Cap-dependent Translation Initiation 6.630287e-01 0.178
R-HSA-72613 Eukaryotic Translation Initiation 6.630287e-01 0.178
R-HSA-373760 L1CAM interactions 6.630287e-01 0.178
R-HSA-1592230 Mitochondrial biogenesis 6.671185e-01 0.176
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 6.676333e-01 0.175
R-HSA-418597 G alpha (z) signalling events 6.676333e-01 0.175
R-HSA-5693538 Homology Directed Repair 6.711683e-01 0.173
R-HSA-168255 Influenza Infection 6.724712e-01 0.172
R-HSA-372790 Signaling by GPCR 6.727901e-01 0.172
R-HSA-72702 Ribosomal scanning and start codon recognition 6.734054e-01 0.172
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER 6.734054e-01 0.172
R-HSA-5578775 Ion homeostasis 6.734054e-01 0.172
R-HSA-75893 TNF signaling 6.734054e-01 0.172
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 6.751782e-01 0.171
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 6.751782e-01 0.171
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 6.790777e-01 0.168
R-HSA-68875 Mitotic Prophase 6.791484e-01 0.168
R-HSA-73886 Chromosome Maintenance 6.830791e-01 0.166
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... 6.846517e-01 0.165
R-HSA-6782135 Dual incision in TC-NER 6.846517e-01 0.165
R-HSA-9772572 Early SARS-CoV-2 Infection Events 6.846517e-01 0.165
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 6.869705e-01 0.163
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 6.869705e-01 0.163
R-HSA-180786 Extension of Telomeres 6.901293e-01 0.161
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures 6.901293e-01 0.161
R-HSA-2132295 MHC class II antigen presentation 6.908226e-01 0.161
R-HSA-9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 6.955120e-01 0.158
R-HSA-8943724 Regulation of PTEN gene transcription 6.955120e-01 0.158
R-HSA-450294 MAP kinase activation 7.008016e-01 0.154
R-HSA-6784531 tRNA processing in the nucleus 7.059996e-01 0.151
R-HSA-9616222 Transcriptional regulation of granulopoiesis 7.059996e-01 0.151
R-HSA-5617833 Cilium Assembly 7.073671e-01 0.150
R-HSA-1852241 Organelle biogenesis and maintenance 7.087057e-01 0.150
R-HSA-114608 Platelet degranulation 7.095023e-01 0.149
R-HSA-6790901 rRNA modification in the nucleus and cytosol 7.111076e-01 0.148
R-HSA-69615 G1/S DNA Damage Checkpoints 7.111076e-01 0.148
R-HSA-5690714 CD22 mediated BCR regulation 7.161272e-01 0.145
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... 7.161272e-01 0.145
R-HSA-936837 Ion transport by P-type ATPases 7.161272e-01 0.145
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 7.251707e-01 0.140
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 7.259071e-01 0.139
R-HSA-5693606 DNA Double Strand Break Response 7.306705e-01 0.136
R-HSA-416476 G alpha (q) signalling events 7.312059e-01 0.136
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 7.340645e-01 0.134
R-HSA-167172 Transcription of the HIV genome 7.353513e-01 0.134
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 7.353513e-01 0.134
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 7.353513e-01 0.134
R-HSA-425407 SLC-mediated transmembrane transport 7.388023e-01 0.131
R-HSA-448424 Interleukin-17 signaling 7.444712e-01 0.128
R-HSA-9764560 Regulation of CDH1 Gene Transcription 7.444712e-01 0.128
R-HSA-376176 Signaling by ROBO receptors 7.448632e-01 0.128
R-HSA-5620920 Cargo trafficking to the periciliary membrane 7.489130e-01 0.126
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 7.489130e-01 0.126
R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activ... 7.489130e-01 0.126
R-HSA-5357801 Programmed Cell Death 7.529532e-01 0.123
R-HSA-199992 trans-Golgi Network Vesicle Budding 7.532778e-01 0.123
R-HSA-5578749 Transcriptional regulation by small RNAs 7.532778e-01 0.123
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 7.532778e-01 0.123
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 7.532778e-01 0.123
R-HSA-1266738 Developmental Biology 7.542501e-01 0.122
R-HSA-69052 Switching of origins to a post-replicative state 7.575671e-01 0.121
R-HSA-9664407 Parasite infection 7.599560e-01 0.119
R-HSA-9664417 Leishmania phagocytosis 7.599560e-01 0.119
R-HSA-9664422 FCGR3A-mediated phagocytosis 7.599560e-01 0.119
R-HSA-674695 RNA Polymerase II Pre-transcription Events 7.617820e-01 0.118
R-HSA-69473 G2/M DNA damage checkpoint 7.617820e-01 0.118
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 7.659239e-01 0.116
R-HSA-162599 Late Phase of HIV Life Cycle 7.690900e-01 0.114
R-HSA-5689603 UCH proteinases 7.699941e-01 0.114
R-HSA-9694635 Translation of Structural Proteins 7.739937e-01 0.111
R-HSA-383280 Nuclear Receptor transcription pathway 7.779241e-01 0.109
R-HSA-4086400 PCP/CE pathway 7.779241e-01 0.109
R-HSA-216083 Integrin cell surface interactions 7.779241e-01 0.109
R-HSA-191273 Cholesterol biosynthesis 7.779241e-01 0.109
R-HSA-418990 Adherens junctions interactions 7.856568e-01 0.105
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 7.864557e-01 0.104
R-HSA-69242 S Phase 7.864557e-01 0.104
R-HSA-9679506 SARS-CoV Infections 7.892850e-01 0.103
R-HSA-5693607 Processing of DNA double-strand break ends 7.893110e-01 0.103
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 7.893110e-01 0.103
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 7.929759e-01 0.101
R-HSA-9707564 Cytoprotection by HMOX1 7.965772e-01 0.099
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 7.973872e-01 0.098
R-HSA-69306 DNA Replication 8.000418e-01 0.097
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 8.001161e-01 0.097
R-HSA-1483257 Phospholipid metabolism 8.007310e-01 0.097
R-HSA-73857 RNA Polymerase II Transcription 8.022414e-01 0.096
R-HSA-1500620 Meiosis 8.035937e-01 0.095
R-HSA-5687128 MAPK6/MAPK4 signaling 8.035937e-01 0.095
R-HSA-168273 Influenza Viral RNA Transcription and Replication 8.052589e-01 0.094
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 8.070109e-01 0.093
R-HSA-9909615 Regulation of PD-L1(CD274) Post-translational modification 8.070109e-01 0.093
R-HSA-2262752 Cellular responses to stress 8.090937e-01 0.092
R-HSA-8953897 Cellular responses to stimuli 8.103365e-01 0.091
R-HSA-162587 HIV Life Cycle 8.103550e-01 0.091
R-HSA-9610379 HCMV Late Events 8.103550e-01 0.091
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 8.103690e-01 0.091
R-HSA-9711097 Cellular response to starvation 8.128584e-01 0.090
R-HSA-1236974 ER-Phagosome pathway 8.200976e-01 0.086
R-HSA-202424 Downstream TCR signaling 8.232287e-01 0.084
R-HSA-112310 Neurotransmitter release cycle 8.232287e-01 0.084
R-HSA-73884 Base Excision Repair 8.232287e-01 0.084
R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance 8.322999e-01 0.080
R-HSA-9772573 Late SARS-CoV-2 Infection Events 8.322999e-01 0.080
R-HSA-68867 Assembly of the pre-replicative complex 8.352193e-01 0.078
R-HSA-9837999 Mitochondrial protein degradation 8.380881e-01 0.077
R-HSA-1474290 Collagen formation 8.380881e-01 0.077
R-HSA-212436 Generic Transcription Pathway 8.401803e-01 0.076
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 8.409071e-01 0.075
R-HSA-418555 G alpha (s) signalling events 8.449325e-01 0.073
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization 8.463993e-01 0.072
R-HSA-6807878 COPI-mediated anterograde transport 8.463993e-01 0.072
R-HSA-9909648 Regulation of PD-L1(CD274) expression 8.470217e-01 0.072
R-HSA-157579 Telomere Maintenance 8.490741e-01 0.071
R-HSA-170834 Signaling by TGF-beta Receptor Complex 8.490741e-01 0.071
R-HSA-5689880 Ub-specific processing proteases 8.490853e-01 0.071
R-HSA-8957275 Post-translational protein phosphorylation 8.517025e-01 0.070
R-HSA-975871 MyD88 cascade initiated on plasma membrane 8.517025e-01 0.070
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 8.517025e-01 0.070
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 8.517025e-01 0.070
R-HSA-421270 Cell-cell junction organization 8.528676e-01 0.069
R-HSA-9678108 SARS-CoV-1 Infection 8.531369e-01 0.069
R-HSA-70171 Glycolysis 8.568232e-01 0.067
R-HSA-9009391 Extra-nuclear estrogen signaling 8.593171e-01 0.066
R-HSA-9020702 Interleukin-1 signaling 8.593171e-01 0.066
R-HSA-5688426 Deubiquitination 8.596243e-01 0.066
R-HSA-388841 Regulation of T cell activation by CD28 family 8.612705e-01 0.065
R-HSA-9842860 Regulation of endogenous retroelements 8.617677e-01 0.065
R-HSA-1474244 Extracellular matrix organization 8.624783e-01 0.064
R-HSA-2559583 Cellular Senescence 8.628368e-01 0.064
R-HSA-1280215 Cytokine Signaling in Immune system 8.645991e-01 0.063
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 8.665421e-01 0.062
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 8.711521e-01 0.060
R-HSA-9692914 SARS-CoV-1-host interactions 8.733972e-01 0.059
R-HSA-418346 Platelet homeostasis 8.733972e-01 0.059
R-HSA-168256 Immune System 8.741995e-01 0.058
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 8.756034e-01 0.058
R-HSA-9700206 Signaling by ALK in cancer 8.756034e-01 0.058
R-HSA-211000 Gene Silencing by RNA 8.756034e-01 0.058
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 8.777713e-01 0.057
R-HSA-1236975 Antigen processing-Cross presentation 8.777713e-01 0.057
R-HSA-2672351 Stimuli-sensing channels 8.777713e-01 0.057
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 8.777713e-01 0.057
R-HSA-449147 Signaling by Interleukins 8.786281e-01 0.056
R-HSA-983712 Ion channel transport 8.788341e-01 0.056
R-HSA-69002 DNA Replication Pre-Initiation 8.799015e-01 0.056
R-HSA-975155 MyD88 dependent cascade initiated on endosome 8.799015e-01 0.056
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 8.819947e-01 0.055
R-HSA-166166 MyD88-independent TLR4 cascade 8.819947e-01 0.055
R-HSA-168898 Toll-like Receptor Cascades 8.821478e-01 0.054
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 8.860727e-01 0.053
R-HSA-927802 Nonsense-Mediated Decay (NMD) 8.860727e-01 0.053
R-HSA-2871796 FCERI mediated MAPK activation 8.860727e-01 0.053
R-HSA-1483249 Inositol phosphate metabolism 8.860727e-01 0.053
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 8.880587e-01 0.052
R-HSA-9609690 HCMV Early Events 8.900697e-01 0.051
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... 8.919279e-01 0.050
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 8.938122e-01 0.049
R-HSA-389948 Co-inhibition by PD-1 8.960494e-01 0.048
R-HSA-948021 Transport to the Golgi and subsequent modification 8.989248e-01 0.046
R-HSA-70326 Glucose metabolism 8.992709e-01 0.046
R-HSA-2980736 Peptide hormone metabolism 8.992709e-01 0.046
R-HSA-73894 DNA Repair 8.996144e-01 0.046
R-HSA-1483206 Glycerophospholipid biosynthesis 9.003346e-01 0.046
R-HSA-9759194 Nuclear events mediated by NFE2L2 9.061167e-01 0.043
R-HSA-74160 Gene expression (Transcription) 9.080489e-01 0.042
R-HSA-9717207 Sensory perception of sweet, bitter, and umami (glutamate) taste 9.093637e-01 0.041
R-HSA-162909 Host Interactions of HIV factors 9.109450e-01 0.041
R-HSA-397014 Muscle contraction 9.134603e-01 0.039
R-HSA-9664323 FCGR3A-mediated IL10 synthesis 9.155258e-01 0.038
R-HSA-69481 G2/M Checkpoints 9.169999e-01 0.038
R-HSA-1474165 Reproduction 9.226445e-01 0.035
R-HSA-5576891 Cardiac conduction 9.239949e-01 0.034
R-HSA-9717189 Sensory perception of taste 9.239949e-01 0.034
R-HSA-446219 Synthesis of substrates in N-glycan biosythesis 9.239949e-01 0.034
R-HSA-162906 HIV Infection 9.301494e-01 0.031
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 9.328118e-01 0.030
R-HSA-6807070 PTEN Regulation 9.351383e-01 0.029
R-HSA-2871837 FCERI mediated NF-kB activation 9.416469e-01 0.026
R-HSA-418594 G alpha (i) signalling events 9.419787e-01 0.026
R-HSA-157118 Signaling by NOTCH 9.421124e-01 0.026
R-HSA-199977 ER to Golgi Anterograde Transport 9.446528e-01 0.025
R-HSA-9758941 Gastrulation 9.465706e-01 0.024
R-HSA-9679191 Potential therapeutics for SARS 9.475045e-01 0.023
R-HSA-9755511 KEAP1-NFE2L2 pathway 9.484221e-01 0.023
R-HSA-9820448 Developmental Cell Lineages of the Exocrine Pancreas 9.493238e-01 0.023
R-HSA-446652 Interleukin-1 family signaling 9.493238e-01 0.023
R-HSA-9609646 HCMV Infection 9.499650e-01 0.022
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 9.510802e-01 0.022
R-HSA-1989781 PPARA activates gene expression 9.519355e-01 0.021
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 9.536018e-01 0.021
R-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... 9.536018e-01 0.021
R-HSA-9006936 Signaling by TGFB family members 9.559938e-01 0.020
R-HSA-9711123 Cellular response to chemical stress 9.616129e-01 0.017
R-HSA-72306 tRNA processing 9.637599e-01 0.016
R-HSA-382551 Transport of small molecules 9.653136e-01 0.015
R-HSA-9664433 Leishmania parasite growth and survival 9.656298e-01 0.015
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection 9.656298e-01 0.015
R-HSA-211945 Phase I - Functionalization of compounds 9.669127e-01 0.015
R-HSA-611105 Respiratory electron transport 9.685351e-01 0.014
R-HSA-8868773 rRNA processing in the nucleus and cytosol 9.736319e-01 0.012
R-HSA-168249 Innate Immune System 9.800261e-01 0.009
R-HSA-212165 Epigenetic regulation of gene expression 9.832234e-01 0.007
R-HSA-8957322 Metabolism of steroids 9.834777e-01 0.007
R-HSA-1643685 Disease 9.839473e-01 0.007
R-HSA-446203 Asparagine N-linked glycosylation 9.840637e-01 0.007
R-HSA-8951664 Neddylation 9.855531e-01 0.006
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 9.874626e-01 0.005
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors 9.876828e-01 0.005
R-HSA-72312 rRNA processing 9.881118e-01 0.005
R-HSA-202733 Cell surface interactions at the vascular wall 9.891204e-01 0.005
R-HSA-6798695 Neutrophil degranulation 9.902442e-01 0.004
R-HSA-9734767 Developmental Cell Lineages 9.931418e-01 0.003
R-HSA-9824439 Bacterial Infection Pathways 9.941522e-01 0.003
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 9.945086e-01 0.002
R-HSA-9824446 Viral Infection Pathways 9.961557e-01 0.002
R-HSA-72766 Translation 9.968441e-01 0.001
R-HSA-1428517 Aerobic respiration and respiratory electron transport 9.982899e-01 0.001
R-HSA-196854 Metabolism of vitamins and cofactors 9.988661e-01 0.000
R-HSA-211859 Biological oxidations 9.993074e-01 0.000
R-HSA-5663205 Infectious disease 9.994089e-01 0.000
R-HSA-8978868 Fatty acid metabolism 9.994842e-01 0.000
R-HSA-500792 GPCR ligand binding 9.997662e-01 0.000
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 9.997821e-01 0.000
R-HSA-597592 Post-translational protein modification 9.998600e-01 0.000
R-HSA-392499 Metabolism of proteins 9.999942e-01 0.000
R-HSA-556833 Metabolism of lipids 9.999959e-01 0.000
R-HSA-9709957 Sensory Perception 9.999997e-01 0.000
R-HSA-1430728 Metabolism 1.000000e+00 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
COTCOT 0.897 0.231 2 0.892
KISKIS 0.896 0.364 1 0.832
CLK3CLK3 0.887 0.300 1 0.901
MOSMOS 0.883 0.187 1 0.905
CDC7CDC7 0.881 0.066 1 0.862
IKKBIKKB 0.879 0.018 -2 0.713
MTORMTOR 0.879 0.046 1 0.869
NLKNLK 0.879 0.200 1 0.934
DSTYKDSTYK 0.878 0.074 2 0.891
PRPKPRPK 0.877 -0.080 -1 0.852
GRK1GRK1 0.877 0.205 -2 0.809
GCN2GCN2 0.874 -0.086 2 0.814
TGFBR2TGFBR2 0.874 0.113 -2 0.867
BMPR2BMPR2 0.874 0.039 -2 0.886
PIM3PIM3 0.874 0.079 -3 0.874
NDR2NDR2 0.873 0.063 -3 0.874
TBK1TBK1 0.873 -0.044 1 0.777
RAF1RAF1 0.873 -0.073 1 0.869
ATRATR 0.872 0.023 1 0.848
BMPR1BBMPR1B 0.872 0.250 1 0.804
HIPK4HIPK4 0.872 0.194 1 0.891
SRPK1SRPK1 0.871 0.202 -3 0.790
CDKL1CDKL1 0.871 0.103 -3 0.837
PDHK4PDHK4 0.870 -0.219 1 0.899
ERK5ERK5 0.870 0.094 1 0.868
NEK6NEK6 0.870 0.037 -2 0.885
SKMLCKSKMLCK 0.870 0.114 -2 0.847
GRK5GRK5 0.870 0.001 -3 0.903
IKKEIKKE 0.869 -0.067 1 0.766
MLK1MLK1 0.869 0.023 2 0.813
CAMK1BCAMK1B 0.868 -0.003 -3 0.876
NEK7NEK7 0.868 -0.047 -3 0.852
IKKAIKKA 0.868 0.032 -2 0.713
CAMK2GCAMK2G 0.868 -0.063 2 0.834
GRK4GRK4 0.868 0.064 -2 0.860
RIPK3RIPK3 0.867 -0.006 3 0.820
ICKICK 0.866 0.147 -3 0.867
GRK7GRK7 0.866 0.193 1 0.806
CDK8CDK8 0.865 0.195 1 0.808
CDKL5CDKL5 0.865 0.100 -3 0.826
DYRK2DYRK2 0.865 0.242 1 0.839
PDHK1PDHK1 0.864 -0.211 1 0.880
ULK2ULK2 0.864 -0.190 2 0.794
PKN3PKN3 0.863 0.013 -3 0.853
GRK6GRK6 0.863 0.039 1 0.861
SRPK3SRPK3 0.863 0.180 -3 0.773
CDK1CDK1 0.863 0.262 1 0.772
ALK4ALK4 0.863 0.123 -2 0.869
CAMLCKCAMLCK 0.862 0.018 -2 0.830
TGFBR1TGFBR1 0.862 0.131 -2 0.850
JNK3JNK3 0.862 0.261 1 0.799
FAM20CFAM20C 0.862 0.095 2 0.634
RSK2RSK2 0.861 0.071 -3 0.795
CDK19CDK19 0.861 0.201 1 0.773
NUAK2NUAK2 0.861 0.009 -3 0.861
ACVR2AACVR2A 0.861 0.173 -2 0.851
NDR1NDR1 0.861 -0.025 -3 0.858
NIKNIK 0.861 -0.083 -3 0.890
ACVR2BACVR2B 0.861 0.172 -2 0.857
SRPK2SRPK2 0.860 0.161 -3 0.718
DAPK2DAPK2 0.860 0.011 -3 0.881
CHAK2CHAK2 0.860 -0.049 -1 0.787
BCKDKBCKDK 0.859 -0.130 -1 0.816
HUNKHUNK 0.859 -0.116 2 0.835
CDK5CDK5 0.859 0.237 1 0.823
PRKD1PRKD1 0.859 0.013 -3 0.832
ANKRD3ANKRD3 0.859 -0.024 1 0.889
JNK2JNK2 0.858 0.258 1 0.768
LATS2LATS2 0.858 0.012 -5 0.743
P90RSKP90RSK 0.858 0.046 -3 0.802
PIM1PIM1 0.858 0.069 -3 0.825
WNK1WNK1 0.858 -0.077 -2 0.841
LATS1LATS1 0.858 0.131 -3 0.881
MST4MST4 0.858 -0.040 2 0.844
ATMATM 0.857 -0.011 1 0.778
PLK1PLK1 0.857 0.043 -2 0.841
MARK4MARK4 0.857 -0.044 4 0.857
MASTLMASTL 0.857 -0.199 -2 0.789
DLKDLK 0.857 -0.085 1 0.870
PKN2PKN2 0.857 -0.020 -3 0.854
ALK2ALK2 0.856 0.136 -2 0.863
P38GP38G 0.856 0.253 1 0.697
TTBK2TTBK2 0.856 -0.089 2 0.720
CLK4CLK4 0.856 0.166 -3 0.797
HIPK2HIPK2 0.856 0.262 1 0.766
CDK18CDK18 0.855 0.230 1 0.750
P38BP38B 0.855 0.246 1 0.767
CK1ECK1E 0.855 0.196 -3 0.696
PKCDPKCD 0.855 0.008 2 0.784
CAMK2DCAMK2D 0.855 -0.048 -3 0.848
MLK3MLK3 0.855 0.001 2 0.736
CDK13CDK13 0.854 0.185 1 0.792
ERK1ERK1 0.854 0.224 1 0.764
CLK2CLK2 0.854 0.244 -3 0.784
NEK9NEK9 0.854 -0.150 2 0.839
BMPR1ABMPR1A 0.854 0.191 1 0.785
ULK1ULK1 0.853 -0.216 -3 0.815
RSK3RSK3 0.853 0.013 -3 0.788
P38AP38A 0.853 0.208 1 0.830
HIPK1HIPK1 0.853 0.234 1 0.856
CDK7CDK7 0.853 0.151 1 0.813
AMPKA1AMPKA1 0.853 -0.051 -3 0.867
PKACGPKACG 0.852 -0.005 -2 0.716
CK1DCK1D 0.852 0.220 -3 0.651
MLK2MLK2 0.851 -0.122 2 0.819
MLK4MLK4 0.851 0.013 2 0.720
RIPK1RIPK1 0.851 -0.165 1 0.855
IRE1IRE1 0.851 -0.056 1 0.821
WNK3WNK3 0.851 -0.263 1 0.849
CAMK2BCAMK2B 0.851 0.014 2 0.808
AURCAURC 0.851 0.052 -2 0.650
VRK2VRK2 0.850 -0.041 1 0.925
TLK2TLK2 0.850 0.024 1 0.807
P38DP38D 0.850 0.270 1 0.709
MEK1MEK1 0.850 -0.090 2 0.855
CLK1CLK1 0.849 0.157 -3 0.760
P70S6KBP70S6KB 0.849 -0.036 -3 0.815
PKRPKR 0.849 -0.029 1 0.868
GRK2GRK2 0.849 0.021 -2 0.742
CDK17CDK17 0.848 0.210 1 0.701
YSK4YSK4 0.848 -0.076 1 0.811
MAPKAPK3MAPKAPK3 0.848 -0.056 -3 0.790
MAPKAPK2MAPKAPK2 0.848 0.017 -3 0.756
DYRK1ADYRK1A 0.848 0.191 1 0.870
TSSK1TSSK1 0.848 -0.027 -3 0.879
TSSK2TSSK2 0.848 -0.070 -5 0.772
PRKD2PRKD2 0.848 -0.016 -3 0.777
DYRK4DYRK4 0.848 0.232 1 0.775
PRP4PRP4 0.847 0.136 -3 0.777
CDK3CDK3 0.847 0.231 1 0.717
NIM1NIM1 0.847 -0.098 3 0.837
CDK12CDK12 0.847 0.183 1 0.769
MEKK3MEKK3 0.846 0.041 1 0.845
ERK2ERK2 0.846 0.168 1 0.809
PLK3PLK3 0.846 -0.029 2 0.796
MSK2MSK2 0.846 0.001 -3 0.785
IRE2IRE2 0.846 -0.044 2 0.751
CK1G1CK1G1 0.846 0.147 -3 0.688
AMPKA2AMPKA2 0.846 -0.043 -3 0.836
AURAAURA 0.846 0.055 -2 0.639
CAMK2ACAMK2A 0.845 0.002 2 0.824
PKCAPKCA 0.845 -0.001 2 0.718
RSK4RSK4 0.845 0.059 -3 0.781
PAK1PAK1 0.844 -0.041 -2 0.759
CK1A2CK1A2 0.844 0.183 -3 0.651
CDK14CDK14 0.844 0.216 1 0.792
PKACBPKACB 0.844 0.070 -2 0.660
HIPK3HIPK3 0.844 0.184 1 0.858
CAMK4CAMK4 0.844 -0.114 -3 0.837
CDK2CDK2 0.844 0.116 1 0.837
PKCBPKCB 0.843 -0.022 2 0.730
MSK1MSK1 0.843 0.046 -3 0.783
SMG1SMG1 0.843 -0.075 1 0.793
PKCGPKCG 0.842 -0.048 2 0.733
MEKK2MEKK2 0.842 0.031 2 0.809
QSKQSK 0.842 -0.022 4 0.839
PERKPERK 0.842 -0.037 -2 0.869
PAK3PAK3 0.842 -0.090 -2 0.748
MYLK4MYLK4 0.841 0.007 -2 0.752
NUAK1NUAK1 0.841 -0.056 -3 0.806
AURBAURB 0.841 0.018 -2 0.648
GRK3GRK3 0.841 0.055 -2 0.716
PHKG1PHKG1 0.841 -0.070 -3 0.843
CDK9CDK9 0.841 0.132 1 0.800
DYRK3DYRK3 0.841 0.188 1 0.858
TLK1TLK1 0.840 -0.022 -2 0.877
PKG2PKG2 0.840 0.021 -2 0.650
AKT2AKT2 0.840 0.068 -3 0.719
PKCZPKCZ 0.840 -0.060 2 0.777
DYRK1BDYRK1B 0.839 0.184 1 0.797
MPSK1MPSK1 0.839 0.112 1 0.833
MEKK1MEKK1 0.839 -0.093 1 0.853
JNK1JNK1 0.839 0.208 1 0.753
PLK4PLK4 0.839 -0.076 2 0.646
PAK2PAK2 0.839 -0.066 -2 0.743
QIKQIK 0.838 -0.150 -3 0.844
SGK3SGK3 0.838 0.025 -3 0.790
HRIHRI 0.838 -0.115 -2 0.872
DNAPKDNAPK 0.838 -0.046 1 0.718
PASKPASK 0.838 0.077 -3 0.896
MEK5MEK5 0.838 -0.161 2 0.831
PKCHPKCH 0.838 -0.062 2 0.717
ZAKZAK 0.838 -0.084 1 0.826
CDK16CDK16 0.838 0.206 1 0.719
CHAK1CHAK1 0.838 -0.174 2 0.775
PRKXPRKX 0.838 0.082 -3 0.718
BRAFBRAF 0.838 -0.097 -4 0.845
MNK2MNK2 0.837 -0.072 -2 0.759
NEK2NEK2 0.836 -0.186 2 0.811
MELKMELK 0.836 -0.104 -3 0.811
MARK2MARK2 0.836 -0.052 4 0.768
PINK1PINK1 0.836 -0.101 1 0.887
MST3MST3 0.836 0.006 2 0.833
SIKSIK 0.836 -0.053 -3 0.778
PRKD3PRKD3 0.835 -0.048 -3 0.755
NEK5NEK5 0.835 -0.081 1 0.855
TAO3TAO3 0.835 -0.007 1 0.841
PAK6PAK6 0.835 -0.001 -2 0.673
MNK1MNK1 0.835 -0.053 -2 0.766
PIM2PIM2 0.834 0.022 -3 0.770
MARK3MARK3 0.834 -0.049 4 0.798
GAKGAK 0.834 0.096 1 0.880
DRAK1DRAK1 0.834 -0.103 1 0.789
MAKMAK 0.833 0.233 -2 0.718
GSK3AGSK3A 0.833 0.054 4 0.429
DCAMKL1DCAMKL1 0.832 -0.039 -3 0.797
CDK10CDK10 0.832 0.184 1 0.779
BRSK1BRSK1 0.831 -0.098 -3 0.808
MAPKAPK5MAPKAPK5 0.830 -0.120 -3 0.748
NEK8NEK8 0.830 -0.083 2 0.817
CHK1CHK1 0.830 -0.128 -3 0.829
WNK4WNK4 0.830 -0.152 -2 0.837
CAMK1GCAMK1G 0.830 -0.053 -3 0.781
BRSK2BRSK2 0.829 -0.142 -3 0.822
SMMLCKSMMLCK 0.829 -0.029 -3 0.837
ERK7ERK7 0.828 0.058 2 0.538
PKACAPKACA 0.828 0.047 -2 0.609
SNRKSNRK 0.828 -0.231 2 0.686
IRAK4IRAK4 0.828 -0.148 1 0.829
AKT1AKT1 0.828 0.051 -3 0.733
GSK3BGSK3B 0.828 -0.028 4 0.422
PDK1PDK1 0.827 -0.019 1 0.848
CK2A2CK2A2 0.827 0.073 1 0.720
PLK2PLK2 0.827 0.017 -3 0.805
TTBK1TTBK1 0.827 -0.155 2 0.642
MARK1MARK1 0.826 -0.112 4 0.815
NEK11NEK11 0.825 -0.155 1 0.835
PKCTPKCT 0.825 -0.064 2 0.723
CDK6CDK6 0.825 0.174 1 0.776
GCKGCK 0.825 -0.006 1 0.824
EEF2KEEF2K 0.825 0.013 3 0.880
MST2MST2 0.825 -0.063 1 0.834
DAPK3DAPK3 0.824 0.030 -3 0.824
TAK1TAK1 0.822 -0.048 1 0.842
TAO2TAO2 0.822 -0.125 2 0.843
DCAMKL2DCAMKL2 0.822 -0.094 -3 0.810
LKB1LKB1 0.822 -0.127 -3 0.842
MINKMINK 0.822 -0.037 1 0.817
CAMKK1CAMKK1 0.821 -0.230 -2 0.712
SSTKSSTK 0.820 -0.093 4 0.825
TNIKTNIK 0.820 -0.014 3 0.904
VRK1VRK1 0.819 -0.080 2 0.849
P70S6KP70S6K 0.819 -0.061 -3 0.731
CDK4CDK4 0.819 0.159 1 0.757
PKCEPKCE 0.819 -0.004 2 0.716
TTKTTK 0.819 0.156 -2 0.879
MAP3K15MAP3K15 0.819 -0.099 1 0.816
MOKMOK 0.819 0.158 1 0.845
HGKHGK 0.818 -0.064 3 0.907
PKCIPKCI 0.818 -0.079 2 0.740
IRAK1IRAK1 0.818 -0.285 -1 0.719
CAMK1DCAMK1D 0.818 -0.032 -3 0.711
PAK5PAK5 0.818 -0.038 -2 0.621
PHKG2PHKG2 0.818 -0.121 -3 0.796
DAPK1DAPK1 0.817 0.024 -3 0.815
CK2A1CK2A1 0.817 0.055 1 0.698
NEK4NEK4 0.816 -0.187 1 0.821
MEKK6MEKK6 0.816 -0.152 1 0.826
HPK1HPK1 0.816 -0.050 1 0.811
PAK4PAK4 0.816 -0.020 -2 0.635
CK1ACK1A 0.816 0.165 -3 0.569
AKT3AKT3 0.815 0.059 -3 0.663
SGK1SGK1 0.815 0.055 -3 0.651
CAMKK2CAMKK2 0.815 -0.244 -2 0.704
LRRK2LRRK2 0.813 -0.190 2 0.848
NEK1NEK1 0.813 -0.151 1 0.836
PDHK3_TYRPDHK3_TYR 0.812 0.165 4 0.894
KHS1KHS1 0.812 -0.025 1 0.806
KHS2KHS2 0.812 0.012 1 0.816
MST1MST1 0.811 -0.137 1 0.816
CHK2CHK2 0.811 -0.003 -3 0.657
OSR1OSR1 0.811 0.006 2 0.802
ROCK2ROCK2 0.810 0.006 -3 0.813
PKN1PKN1 0.810 -0.037 -3 0.740
MAP2K6_TYRMAP2K6_TYR 0.808 0.144 -1 0.865
MAP2K4_TYRMAP2K4_TYR 0.808 0.089 -1 0.868
PDHK4_TYRPDHK4_TYR 0.807 0.150 2 0.891
MRCKBMRCKB 0.807 -0.013 -3 0.758
RIPK2RIPK2 0.807 -0.260 1 0.790
LOKLOK 0.807 -0.161 -2 0.718
MEK2MEK2 0.806 -0.279 2 0.820
YSK1YSK1 0.806 -0.129 2 0.802
MRCKAMRCKA 0.806 -0.035 -3 0.777
SLKSLK 0.806 -0.144 -2 0.675
PBKPBK 0.805 -0.035 1 0.797
STK33STK33 0.805 -0.198 2 0.631
CAMK1ACAMK1A 0.805 -0.019 -3 0.672
PDHK1_TYRPDHK1_TYR 0.804 0.079 -1 0.871
BMPR2_TYRBMPR2_TYR 0.804 0.063 -1 0.849
DMPK1DMPK1 0.804 0.042 -3 0.776
YANK3YANK3 0.802 -0.022 2 0.422
PKMYT1_TYRPKMYT1_TYR 0.802 -0.022 3 0.900
TESK1_TYRTESK1_TYR 0.802 -0.080 3 0.923
SBKSBK 0.801 0.030 -3 0.595
ALPHAK3ALPHAK3 0.801 -0.016 -1 0.747
TXKTXK 0.800 0.172 1 0.849
BUB1BUB1 0.800 -0.032 -5 0.718
MAP2K7_TYRMAP2K7_TYR 0.800 -0.158 2 0.868
PKG1PKG1 0.800 -0.019 -2 0.567
HASPINHASPIN 0.799 -0.046 -1 0.627
FGRFGR 0.798 0.088 1 0.869
YES1YES1 0.797 0.083 -1 0.859
NEK3NEK3 0.797 -0.220 1 0.809
BLKBLK 0.797 0.170 -1 0.838
LCKLCK 0.796 0.132 -1 0.837
EPHA6EPHA6 0.796 0.007 -1 0.853
PINK1_TYRPINK1_TYR 0.795 -0.183 1 0.889
EPHB4EPHB4 0.795 0.007 -1 0.843
CSF1RCSF1R 0.795 0.014 3 0.842
CK1G3CK1G3 0.795 0.161 -3 0.526
ASK1ASK1 0.795 -0.166 1 0.808
MYO3BMYO3B 0.795 -0.080 2 0.816
ROCK1ROCK1 0.794 -0.017 -3 0.773
ABL2ABL2 0.794 0.029 -1 0.809
RETRET 0.794 -0.102 1 0.850
HCKHCK 0.794 0.054 -1 0.837
ROS1ROS1 0.793 -0.034 3 0.835
MYO3AMYO3A 0.793 -0.098 1 0.816
BIKEBIKE 0.792 -0.012 1 0.763
LIMK2_TYRLIMK2_TYR 0.792 -0.085 -3 0.884
MST1RMST1R 0.792 -0.102 3 0.862
TYRO3TYRO3 0.792 -0.083 3 0.856
TYK2TYK2 0.791 -0.143 1 0.842
FERFER 0.791 -0.046 1 0.878
FYNFYN 0.791 0.135 -1 0.825
JAK2JAK2 0.790 -0.094 1 0.844
CRIKCRIK 0.790 -0.015 -3 0.736
INSRRINSRR 0.789 -0.017 3 0.805
ITKITK 0.789 0.018 -1 0.797
ABL1ABL1 0.788 -0.009 -1 0.805
KITKIT 0.788 -0.018 3 0.843
SRMSSRMS 0.788 -0.009 1 0.861
JAK3JAK3 0.787 -0.075 1 0.836
TAO1TAO1 0.787 -0.162 1 0.776
LIMK1_TYRLIMK1_TYR 0.787 -0.234 2 0.855
STLK3STLK3 0.786 -0.172 1 0.794
EPHB1EPHB1 0.786 -0.037 1 0.858
METMET 0.785 0.000 3 0.830
EPHB2EPHB2 0.785 -0.006 -1 0.826
EPHA4EPHA4 0.785 -0.035 2 0.794
BMXBMX 0.785 0.010 -1 0.726
DDR1DDR1 0.784 -0.199 4 0.812
EPHB3EPHB3 0.783 -0.050 -1 0.835
KDRKDR 0.783 -0.039 3 0.811
FGFR2FGFR2 0.783 -0.099 3 0.844
FLT3FLT3 0.783 -0.088 3 0.850
TECTEC 0.783 -0.003 -1 0.752
JAK1JAK1 0.782 -0.027 1 0.793
FLT1FLT1 0.781 0.002 -1 0.811
TNK2TNK2 0.781 -0.073 3 0.800
LYNLYN 0.781 0.023 3 0.781
TNNI3K_TYRTNNI3K_TYR 0.780 -0.016 1 0.858
PDGFRBPDGFRB 0.780 -0.158 3 0.858
SRCSRC 0.779 0.052 -1 0.826
MERTKMERTK 0.779 -0.059 3 0.823
FGFR1FGFR1 0.778 -0.129 3 0.819
BTKBTK 0.778 -0.125 -1 0.770
CK1G2CK1G2 0.777 0.124 -3 0.613
TEKTEK 0.776 -0.149 3 0.794
AAK1AAK1 0.776 0.041 1 0.659
FGFR3FGFR3 0.776 -0.076 3 0.817
FRKFRK 0.776 -0.050 -1 0.838
EPHA7EPHA7 0.775 -0.057 2 0.794
ERBB2ERBB2 0.775 -0.107 1 0.799
SYKSYK 0.775 0.101 -1 0.768
AXLAXL 0.775 -0.144 3 0.829
NTRK1NTRK1 0.774 -0.164 -1 0.832
WEE1_TYRWEE1_TYR 0.774 -0.082 -1 0.735
ALKALK 0.773 -0.142 3 0.770
PTK2PTK2 0.773 0.063 -1 0.775
NTRK3NTRK3 0.772 -0.100 -1 0.794
INSRINSR 0.772 -0.124 3 0.788
TNK1TNK1 0.772 -0.159 3 0.837
NEK10_TYRNEK10_TYR 0.772 -0.172 1 0.735
EPHA3EPHA3 0.772 -0.122 2 0.764
EGFREGFR 0.771 -0.036 1 0.716
PTK6PTK6 0.771 -0.188 -1 0.735
PDGFRAPDGFRA 0.771 -0.235 3 0.855
PTK2BPTK2B 0.771 -0.037 -1 0.795
YANK2YANK2 0.770 -0.042 2 0.438
NTRK2NTRK2 0.770 -0.175 3 0.809
LTKLTK 0.770 -0.160 3 0.791
FLT4FLT4 0.769 -0.152 3 0.807
EPHA5EPHA5 0.769 -0.056 2 0.777
EPHA8EPHA8 0.769 -0.057 -1 0.805
DDR2DDR2 0.768 -0.054 3 0.786
FGFR4FGFR4 0.768 -0.051 -1 0.767
MATKMATK 0.767 -0.113 -1 0.722
EPHA1EPHA1 0.767 -0.149 3 0.813
ERBB4ERBB4 0.762 -0.003 1 0.718
CSKCSK 0.760 -0.169 2 0.797
IGF1RIGF1R 0.760 -0.109 3 0.730
EPHA2EPHA2 0.759 -0.063 -1 0.770
ZAP70ZAP70 0.755 0.053 -1 0.687
MUSKMUSK 0.749 -0.187 1 0.701
FESFES 0.745 -0.133 -1 0.712