Motif 859 (n=61)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0C4DFX4 | None | S2194 | ochoa | Snf2 related CREBBP activator protein | None |
| A6NKT7 | RGPD3 | T1178 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| H3BQZ7 | HNRNPUL2-BSCL2 | S188 | ochoa | Heterogeneous nuclear ribonucleoprotein U-like protein 2 | None |
| O14715 | RGPD8 | T1177 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O60563 | CCNT1 | S363 | ochoa | Cyclin-T1 (CycT1) (Cyclin-T) | Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II) (PubMed:16109376, PubMed:16109377, PubMed:30134174, PubMed:35393539). Required to activate the protein kinase activity of CDK9: acts by mediating formation of liquid-liquid phase separation (LLPS) that enhances binding of P-TEFb to the CTD of RNA Pol II (PubMed:29849146, PubMed:35393539). {ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377, ECO:0000269|PubMed:29849146, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:35393539}.; FUNCTION: (Microbial infection) In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes. {ECO:0000269|PubMed:10329125, ECO:0000269|PubMed:10329126}. |
| O75037 | KIF21B | S1272 | ochoa | Kinesin-like protein KIF21B | Plus-end directed microtubule-dependent motor protein which displays processive activity. Is involved in regulation of microtubule dynamics, synapse function and neuronal morphology, including dendritic tree branching and spine formation. Plays a role in lerning and memory. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptor to cell surface. {ECO:0000250|UniProtKB:Q9QXL1}. |
| O75396 | SEC22B | S174 | ochoa | Vesicle-trafficking protein SEC22b (ER-Golgi SNARE of 24 kDa) (ERS-24) (ERS24) (SEC22 vesicle-trafficking protein homolog B) (SEC22 vesicle-trafficking protein-like 1) | SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER. {ECO:0000269|PubMed:15272311}. |
| P04049 | RAF1 | S497 | ochoa|psp | RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) | Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}. |
| P06239 | LCK | S158 | ochoa|psp | Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK) | Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules are recruited, ultimately leading to lymphokine production. LCK also contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, which leads to hyperphosphorylation and activation of LCK. Also plays a role in the IL2 receptor-linked signaling pathway that controls the T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Phosphorylates other substrates including RUNX3, PTK2B/PYK2, the microtubule-associated protein MAPT, RHOH or TYROBP. Interacts with FYB2 (PubMed:27335501). {ECO:0000269|PubMed:16339550, ECO:0000269|PubMed:16709819, ECO:0000269|PubMed:20028775, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:20851766, ECO:0000269|PubMed:21269457, ECO:0000269|PubMed:22080863, ECO:0000269|PubMed:27335501, ECO:0000269|PubMed:38614099}. |
| P0DJD0 | RGPD1 | T1162 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | T1170 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P10398 | ARAF | S458 | ochoa | Serine/threonine-protein kinase A-Raf (EC 2.7.11.1) (Proto-oncogene A-Raf) (Proto-oncogene A-Raf-1) (Proto-oncogene Pks) | Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade. Phosphorylates PFKFB2 (PubMed:36402789). {ECO:0000269|PubMed:22609986, ECO:0000269|PubMed:36402789}.; FUNCTION: [Isoform 2]: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation. {ECO:0000269|PubMed:22609986}. |
| P15056 | BRAF | S605 | ochoa|psp | Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) | Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). Phosphorylates PFKFB2 (PubMed:36402789). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179). {ECO:0000269|PubMed:1508179, ECO:0000269|PubMed:21441910, ECO:0000269|PubMed:29433126, ECO:0000269|PubMed:36402789, ECO:0000305}. |
| P23919 | DTYMK | S88 | psp | Thymidylate kinase (EC 2.7.4.9) (dTMP kinase) | Catalyzes the phosphorylation of thymidine monophosphate (dTMP) to thymidine diphosphate (dTDP), the immediate precursor for the DNA building block dTTP, with ATP as the preferred phosphoryl donor in the presence of Mg(2+). {ECO:0000269|PubMed:12614151, ECO:0000269|PubMed:2017365, ECO:0000269|PubMed:34918187, ECO:0000269|PubMed:8024690, ECO:0000305|PubMed:18469}. |
| P24539 | ATP5PB | S155 | ochoa | ATP synthase peripheral stalk subunit b, mitochondrial (ATP synthase F(0) complex subunit B1, mitochondrial) (ATP synthase peripheral stalk-membrane subunit b) (ATP synthase proton-transporting mitochondrial F(0) complex subunit B1) (ATP synthase subunit b) (ATPase subunit b) | Subunit b, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (PubMed:37244256). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (PubMed:37244256). Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (By similarity). {ECO:0000250|UniProtKB:P13619, ECO:0000250|UniProtKB:P19483, ECO:0000269|PubMed:37244256, ECO:0000305|PubMed:37244256}. |
| P29350 | PTPN6 | S140 | ochoa | Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Protein-tyrosine phosphatase SHP-1) (SH-PTP1) | Tyrosine phosphatase enzyme that plays important roles in controlling immune signaling pathways and fundamental physiological processes such as hematopoiesis (PubMed:14739280, PubMed:29925997). Dephosphorylates and negatively regulate several receptor tyrosine kinases (RTKs) such as EGFR, PDGFR and FGFR, thereby modulating their signaling activities (PubMed:21258366, PubMed:9733788). When recruited to immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing receptors such as immunoglobulin-like transcript 2/LILRB1, programmed cell death protein 1/PDCD1, CD3D, CD22, CLEC12A and other receptors involved in immune regulation, initiates their dephosphorylation and subsequently inhibits downstream signaling events (PubMed:11907092, PubMed:14739280, PubMed:37932456, PubMed:38166031). Modulates the signaling of several cytokine receptors including IL-4 receptor (PubMed:9065461). Additionally, targets multiple cytoplasmic signaling molecules including STING1, LCK or STAT1 among others involved in diverse cellular processes including modulation of T-cell activation or cGAS-STING signaling (PubMed:34811497, PubMed:38532423). Within the nucleus, negatively regulates the activity of some transcription factors such as NFAT5 via direct dephosphorylation. Also acts as a key transcriptional regulator of hepatic gluconeogenesis by controlling recruitment of RNA polymerase II to the PCK1 promoter together with STAT5A (PubMed:37595871). {ECO:0000269|PubMed:10574931, ECO:0000269|PubMed:11266449, ECO:0000269|PubMed:11907092, ECO:0000269|PubMed:14739280, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:29925997, ECO:0000269|PubMed:34811497, ECO:0000269|PubMed:37595871, ECO:0000269|PubMed:37932456, ECO:0000269|PubMed:38166031, ECO:0000269|PubMed:38532423, ECO:0000269|PubMed:9065461, ECO:0000269|PubMed:9733788}. |
| P32298 | GRK4 | S139 | psp | G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1) | Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2. {ECO:0000269|PubMed:19520868, ECO:0000269|PubMed:8626439}. |
| P32298 | GRK4 | S485 | psp | G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1) | Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2. {ECO:0000269|PubMed:19520868, ECO:0000269|PubMed:8626439}. |
| P34947 | GRK5 | S484 | ochoa|psp | G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5) | Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein-coupled receptors (GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. Phosphorylates a variety of GPCRs, including adrenergic receptors, muscarinic acetylcholine receptors (more specifically Gi-coupled M2/M4 subtypes), dopamine receptors and opioid receptors. In addition to GPCRs, also phosphorylates various substrates: Hsc70-interacting protein/ST13, TP53/p53, HDAC5, and arrestin-1/ARRB1. Phosphorylation of ARRB1 by GRK5 inhibits G-protein independent MAPK1/MAPK3 signaling downstream of 5HT4-receptors. Phosphorylation of HDAC5, a repressor of myocyte enhancer factor 2 (MEF2) leading to nuclear export of HDAC5 and allowing MEF2-mediated transcription. Phosphorylation of TP53/p53, a crucial tumor suppressor, inhibits TP53/p53-mediated apoptosis. Phosphorylation of ST13 regulates internalization of the chemokine receptor. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor, LRP6 during Wnt signaling (in vitro). {ECO:0000269|PubMed:19661922, ECO:0000269|PubMed:19801552, ECO:0000269|PubMed:20038610, ECO:0000269|PubMed:20124405, ECO:0000269|PubMed:21728385}. |
| P35221 | CTNNA1 | S655 | ochoa|psp | Catenin alpha-1 (Alpha E-catenin) (Cadherin-associated protein) (Renal carcinoma antigen NY-REN-13) | Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). May play a crucial role in cell differentiation. {ECO:0000250|UniProtKB:P26231, ECO:0000269|PubMed:25653389}. |
| P43250 | GRK6 | S484 | ochoa|psp | G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6) | Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro). {ECO:0000250, ECO:0000269|PubMed:19801552, ECO:0000269|PubMed:20048153}. |
| P49792 | RANBP2 | T2153 | ochoa|psp | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P62910 | RPL32 | S105 | ochoa | Large ribosomal subunit protein eL32 (60S ribosomal protein L32) | Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| P78312 | FAM193A | S858 | ochoa | Protein FAM193A (Protein IT14) | None |
| P78344 | EIF4G2 | S443 | ochoa | Eukaryotic translation initiation factor 4 gamma 2 (eIF-4-gamma 2) (eIF-4G 2) (eIF4G 2) (Death-associated protein 5) (DAP-5) (p97) | Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases. {ECO:0000269|PubMed:11511540, ECO:0000269|PubMed:11943866, ECO:0000269|PubMed:9032289, ECO:0000269|PubMed:9049310}. |
| Q01484 | ANK2 | S2172 | ochoa | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}. |
| Q03188 | CENPC | S55 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
| Q10571 | MN1 | S1034 | ochoa | Transcriptional activator MN1 (Probable tumor suppressor protein MN1) | Transcriptional activator which specifically regulates expression of TBX22 in the posterior region of the developing palate. Required during later stages of palate development for growth and medial fusion of the palatal shelves. Promotes maturation and normal function of calvarial osteoblasts, including expression of the osteoclastogenic cytokine TNFSF11/RANKL. Necessary for normal development of the membranous bones of the skull (By similarity). May play a role in tumor suppression (Probable). {ECO:0000250|UniProtKB:D3YWE6, ECO:0000305|PubMed:7731706}. |
| Q12851 | MAP4K2 | S365 | ochoa | Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (B lymphocyte serine/threonine-protein kinase) (Germinal center kinase) (GC kinase) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Rab8-interacting protein) | Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway and to a lesser extent of the p38 MAPKs signaling pathway. Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including pathogen-associated molecular patterns (PAMPs) such as polyinosine-polycytidine (poly(IC)), lipopolysaccharides (LPS), lipid A, peptidoglycan (PGN), or bacterial flagellin. To a lesser degree, IL-1 and engagement of CD40 also stimulate MAP4K2-mediated JNKs activation. The requirement for MAP4K2/GCK is most pronounced for LPS signaling, and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8. Enhances MAP3K1 oligomerization, which may relieve N-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. Also mediates the SAP/JNK signaling pathway and the p38 MAPKs signaling pathway through activation of the MAP3Ks MAP3K10/MLK2 and MAP3K11/MLK3. May play a role in the regulation of vesicle targeting or fusion. regulation of vesicle targeting or fusion. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:11784851, ECO:0000269|PubMed:15456887, ECO:0000269|PubMed:17584736, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:7477268, ECO:0000269|PubMed:7515885, ECO:0000269|PubMed:9712898}. |
| Q12912 | IRAG2 | S93 | ochoa | Inositol 1,4,5-triphosphate receptor associated 2 (Lymphoid-restricted membrane protein) (Protein Jaw1) [Cleaved into: Processed inositol 1,4,5-triphosphate receptor associated 2] | Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion. Plays a role in maintaining nuclear shape, maybe as a component of the LINC complex and through interaction with microtubules. Plays a role in the regulation of cellular excitability by regulating the hyperpolarization-activated cyclic nucleotide-gated HCN4 channel activity (By similarity). {ECO:0000250|UniProtKB:Q60664}. |
| Q13813 | SPTAN1 | S416 | ochoa | Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. |
| Q14151 | SAFB2 | S276 | ochoa | Scaffold attachment factor B2 (SAF-B2) | Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation. |
| Q15424 | SAFB | S277 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q1KMD3 | HNRNPUL2 | S188 | ochoa | Heterogeneous nuclear ribonucleoprotein U-like protein 2 (Scaffold-attachment factor A2) (SAF-A2) | None |
| Q5VT25 | CDC42BPA | S234 | psp | Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha) | Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration (PubMed:15723050, PubMed:9092543, PubMed:9418861). Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates: PPP1R12A, LIMK1 and LIMK2 (PubMed:11340065, PubMed:11399775). May play a role in TFRC-mediated iron uptake (PubMed:20188707). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). Triggers the formation of an extrusion apical actin ring required for epithelial extrusion of apoptotic cells (PubMed:29162624). {ECO:0000250|UniProtKB:Q3UU96, ECO:0000269|PubMed:11340065, ECO:0000269|PubMed:11399775, ECO:0000269|PubMed:15723050, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:20188707, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:29162624, ECO:0000269|PubMed:9092543, ECO:0000269|PubMed:9418861}. |
| Q6ZRS2 | SRCAP | S2371 | ochoa | Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) | Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}. |
| Q8NFC6 | BOD1L1 | S1095 | ochoa | Biorientation of chromosomes in cell division protein 1-like 1 | Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}. |
| Q8NI35 | PATJ | S781 | ochoa | InaD-like protein (Inadl protein) (hINADL) (Channel-interacting PDZ domain-containing protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) | Scaffolding protein that facilitates the localization of proteins to the cell membrane (PubMed:11927608, PubMed:16678097, PubMed:22006950). Required for the correct formation of tight junctions and epithelial apico-basal polarity (PubMed:11927608, PubMed:16678097). Acts (via its L27 domain) as an apical connector and elongation factor for multistranded TJP1/ZO1 condensates that form a tight junction belt, thereby required for the formation of the tight junction-mediated cell barrier (By similarity). Positively regulates epithelial cell microtubule elongation and cell migration, possibly via facilitating localization of PRKCI/aPKC and PAR3D/PAR3 at the leading edge of migrating cells (By similarity). Plays a role in the correct reorientation of the microtubule-organizing center during epithelial migration (By similarity). May regulate the surface expression and/or function of ASIC3 in sensory neurons (By similarity). May recruit ARHGEF18 to apical cell-cell boundaries (PubMed:22006950). {ECO:0000250|UniProtKB:E2QYC9, ECO:0000250|UniProtKB:Q63ZW7, ECO:0000269|PubMed:11927608, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:22006950}. |
| Q8WUI4 | HDAC7 | S595 | ochoa | Histone deacetylase 7 (HD7) (EC 3.5.1.98) (Histone deacetylase 7A) (HD7a) (Protein deacetylase HDAC7) (EC 3.5.1.-) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C (By similarity). During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene (PubMed:12239305). Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565). Serves as a corepressor of RARA, causing its deacetylation and inhibition of RARE DNA element binding (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758). Also acetylates non-histone proteins, such as ALKBH5 (PubMed:37369679). {ECO:0000250|UniProtKB:Q8C2B3, ECO:0000269|PubMed:12239305, ECO:0000269|PubMed:17360565, ECO:0000269|PubMed:28167758, ECO:0000269|PubMed:37369679}. |
| Q8WWI1 | LMO7 | S1177 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q92574 | TSC1 | S270 | ochoa | Hamartin (Tuberous sclerosis 1 protein) | Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12906785, PubMed:15340059, PubMed:24529379, PubMed:28215400). The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12906785, PubMed:15340059, PubMed:24529379). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12271141, PubMed:24529379, PubMed:28215400, PubMed:33215753). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Within the TSC-TBC complex, TSC1 stabilizes TSC2 and prevents TSC2 self-aggregation (PubMed:10585443, PubMed:28215400). Acts as a tumor suppressor (PubMed:9242607). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 (PubMed:29127155). Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity (PubMed:29127155). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155). Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1 (PubMed:16464865, PubMed:29127155). {ECO:0000250|UniProtKB:Q9Z136, ECO:0000269|PubMed:10585443, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:16464865, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:29127155, ECO:0000269|PubMed:33215753, ECO:0000269|PubMed:9242607}. |
| Q96IT1 | ZNF496 | S392 | ochoa | Zinc finger protein 496 (Zinc finger protein with KRAB and SCAN domains 17) | DNA-binding transcription factor that can both act as an activator and a repressor. {ECO:0000250}. |
| Q96SN8 | CDK5RAP2 | S140 | psp | CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215) | Potential regulator of CDK5 activity via its interaction with CDK5R1 (PubMed:15164053). Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter (PubMed:19282672). Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends (PubMed:18042621, PubMed:17959831, PubMed:19553473). Regulates centrosomal maturation by recruitment of the gamma-tubulin ring complex (gTuRC) onto centrosomes (PubMed:18042621, PubMed:17959831, PubMed:26485573, PubMed:39321809). In complex with PDE4DIP isoform 13/MMG8/SMYLE, MAPRE1 and AKAP9, contributes to microtubules nucleation and extension from the centrosome to the cell periphery (PubMed:29162697). Required for the recruitment of AKAP9 to centrosomes (PubMed:29162697). Plays a role in neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q8K389, ECO:0000269|PubMed:15164053, ECO:0000269|PubMed:17959831, ECO:0000269|PubMed:18042621, ECO:0000269|PubMed:19282672, ECO:0000269|PubMed:19553473, ECO:0000269|PubMed:26485573, ECO:0000269|PubMed:29162697, ECO:0000269|PubMed:39321809}. |
| Q99666 | RGPD5 | T1177 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q9BSW7 | SYT17 | S67 | ochoa | Synaptotagmin-17 (Protein B/K) (Synaptotagmin XVII) (SytXVII) | Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000269|PubMed:23999003}. |
| Q9BZ29 | DOCK9 | S1282 | ochoa | Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin-1) (Zizimin-1) | Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation. {ECO:0000269|PubMed:12172552, ECO:0000269|PubMed:19745154}. |
| Q9C0G0 | ZNF407 | S822 | ochoa | Zinc finger protein 407 | May be involved in transcriptional regulation. |
| Q9H5J0 | ZBTB3 | S213 | ochoa | Zinc finger and BTB domain-containing protein 3 | May be involved in transcriptional regulation. |
| Q9NPG3 | UBN1 | S336 | ochoa | Ubinuclein-1 (HIRA-binding protein) (Protein VT4) (Ubiquitously expressed nuclear protein) | Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:19029251}. |
| Q9NVI1 | FANCI | S559 | psp | Fanconi anemia group I protein (Protein FACI) | Plays an essential role in the repair of DNA double-strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites (PubMed:17412408, PubMed:17460694, PubMed:17452773, PubMed:19111657, PubMed:36385258). The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA (PubMed:19589784). Participates in S phase and G2 phase checkpoint activation upon DNA damage (PubMed:25862789). {ECO:0000250|UniProtKB:B0I564, ECO:0000269|PubMed:17412408, ECO:0000269|PubMed:17452773, ECO:0000269|PubMed:17460694, ECO:0000269|PubMed:19111657, ECO:0000269|PubMed:19589784, ECO:0000269|PubMed:25862789, ECO:0000269|PubMed:36385258}. |
| Q9NYF8 | BCLAF1 | S525 | ochoa | Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) | Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}. |
| Q9UHG0 | DCDC2 | S433 | ochoa | Doublecortin domain-containing protein 2 (Protein RU2S) | Protein that plays a role in the inhibition of canonical Wnt signaling pathway (PubMed:25557784). May be involved in neuronal migration during development of the cerebral neocortex (By similarity). Involved in the control of ciliogenesis and ciliary length (PubMed:25601850, PubMed:27319779). {ECO:0000250|UniProtKB:D3ZR10, ECO:0000269|PubMed:25557784, ECO:0000269|PubMed:25601850, ECO:0000269|PubMed:27319779}. |
| Q9UKK3 | PARP4 | S1504 | ochoa | Protein mono-ADP-ribosyltransferase PARP4 (EC 2.4.2.-) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Poly [ADP-ribose] polymerase 4) (PARP-4) (Vault poly(ADP-ribose) polymerase) (VPARP) | Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. {ECO:0000269|PubMed:25043379}. |
| Q9UL26 | RAB22A | S175 | ochoa | Ras-related protein Rab-22A (Rab-22) | Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes (PubMed:16537905). Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth (PubMed:21849477). Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form (PubMed:16537905). {ECO:0000269|PubMed:16537905, ECO:0000269|PubMed:21849477}. |
| Q9ULW3 | ABT1 | S188 | ochoa | Activator of basal transcription 1 (hABT1) (Basal transcriptional activator) | Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes (By similarity). {ECO:0000250}. |
| Q9Y490 | TLN1 | S992 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| Q9Y6K9 | IKBKG | S68 | psp | NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier) | Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor (PubMed:14695475, PubMed:20724660, PubMed:21518757, PubMed:9751060). Its binding to scaffolding polyubiquitin plays a key role in IKK activation by multiple signaling receptor pathways (PubMed:16547522, PubMed:18287044, PubMed:19033441, PubMed:19185524, PubMed:21606507, PubMed:27777308, PubMed:33567255). Can recognize and bind both 'Lys-63'-linked and linear polyubiquitin upon cell stimulation, with a much higher affinity for linear polyubiquitin (PubMed:16547522, PubMed:18287044, PubMed:19033441, PubMed:19185524, PubMed:21606507, PubMed:27777308). Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3 (PubMed:19854139). Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination (PubMed:20724660). {ECO:0000269|PubMed:14695475, ECO:0000269|PubMed:16547522, ECO:0000269|PubMed:18287044, ECO:0000269|PubMed:19033441, ECO:0000269|PubMed:19185524, ECO:0000269|PubMed:19854139, ECO:0000269|PubMed:20724660, ECO:0000269|PubMed:21518757, ECO:0000269|PubMed:21606507, ECO:0000269|PubMed:27777308, ECO:0000269|PubMed:33567255, ECO:0000269|PubMed:9751060}.; FUNCTION: (Microbial infection) Also considered to be a mediator for HTLV-1 Tax oncoprotein activation of NF-kappa-B. {ECO:0000269|PubMed:10364167, ECO:0000269|PubMed:11064457}. |
| Q9BQS8 | FYCO1 | S669 | Sugiyama | FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7) | May mediate microtubule plus end-directed vesicle transport. {ECO:0000269|PubMed:20100911}. |
| O95425 | SVIL | S130 | Sugiyama | Supervillin (Archvillin) (p205/p250) | [Isoform 1]: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699). Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (PubMed:19109420). {ECO:0000269|PubMed:12711699, ECO:0000269|PubMed:19109420}.; FUNCTION: [Isoform 2]: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity). {ECO:0000250|UniProtKB:O46385}. |
| Q06124 | PTPN11 | S142 | Sugiyama | Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3) | Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus (PubMed:10655584, PubMed:14739280, PubMed:18559669, PubMed:18829466, PubMed:26742426, PubMed:28074573). Positively regulates MAPK signal transduction pathway (PubMed:28074573). Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed:28074573). Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity (PubMed:18559669). Dephosphorylates CDC73 (PubMed:26742426). Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification (By similarity). Dephosphorylates tyrosine-phosphorylated NEDD9/CAS-L (PubMed:19275884). {ECO:0000250|UniProtKB:P35235, ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:14739280, ECO:0000269|PubMed:18559669, ECO:0000269|PubMed:18829466, ECO:0000269|PubMed:19275884, ECO:0000269|PubMed:26742426, ECO:0000269|PubMed:28074573}. |
| Q7Z7E8 | UBE2Q1 | S401 | Sugiyama | Ubiquitin-conjugating enzyme E2 Q1 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme Q1) (Protein NICE-5) (Ubiquitin carrier protein Q1) (Ubiquitin-protein ligase Q1) | Catalyzes the covalent attachment of ubiquitin to other proteins (PubMed:22496338). May be involved in hormonal homeostasis in females. Involved in regulation of B4GALT1 cell surface expression, B4GALT1-mediated cell adhesion to laminin and embryoid body formation (By similarity). {ECO:0000250|UniProtKB:Q7TSS2, ECO:0000269|PubMed:22496338}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.000003 | 5.556 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 0.000012 | 4.915 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 0.000016 | 4.792 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 0.000016 | 4.792 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.000019 | 4.716 |
| R-HSA-210990 | PECAM1 interactions | 0.000033 | 4.482 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.000042 | 4.379 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.000063 | 4.199 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.000092 | 4.037 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.000092 | 4.037 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.000092 | 4.037 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.000063 | 4.199 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.000092 | 4.037 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.000289 | 3.540 |
| R-HSA-9927353 | Co-inhibition by BTLA | 0.000435 | 3.362 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.000533 | 3.273 |
| R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 0.000566 | 3.247 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.000713 | 3.147 |
| R-HSA-5673000 | RAF activation | 0.000763 | 3.118 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.000841 | 3.075 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.000874 | 3.058 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.001271 | 2.896 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.001424 | 2.847 |
| R-HSA-913531 | Interferon Signaling | 0.001733 | 2.761 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.001759 | 2.755 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.001759 | 2.755 |
| R-HSA-877312 | Regulation of IFNG signaling | 0.002216 | 2.654 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.002381 | 2.623 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.002789 | 2.555 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 0.003099 | 2.509 |
| R-HSA-391160 | Signal regulatory protein family interactions | 0.002789 | 2.555 |
| R-HSA-432142 | Platelet sensitization by LDL | 0.004491 | 2.348 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.004304 | 2.366 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 0.005277 | 2.278 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.004933 | 2.307 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.005045 | 2.297 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.005062 | 2.296 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.005568 | 2.254 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.006565 | 2.183 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 0.006565 | 2.183 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.006485 | 2.188 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.007764 | 2.110 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.008672 | 2.062 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.008995 | 2.046 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.009501 | 2.022 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.009522 | 2.021 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.010063 | 1.997 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.010592 | 1.975 |
| R-HSA-422475 | Axon guidance | 0.010663 | 1.972 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.012358 | 1.908 |
| R-HSA-176034 | Interactions of Tat with host cellular proteins | 0.012774 | 1.894 |
| R-HSA-5602636 | IKBKB deficiency causes SCID | 0.012774 | 1.894 |
| R-HSA-5603027 | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... | 0.012774 | 1.894 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.015048 | 1.823 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.016404 | 1.785 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.016404 | 1.785 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.015048 | 1.823 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.013583 | 1.867 |
| R-HSA-1280218 | Adaptive Immune System | 0.015224 | 1.817 |
| R-HSA-1500931 | Cell-Cell communication | 0.014749 | 1.831 |
| R-HSA-162582 | Signal Transduction | 0.014600 | 1.836 |
| R-HSA-9675108 | Nervous system development | 0.014678 | 1.833 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.017559 | 1.756 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.018565 | 1.731 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.018565 | 1.731 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.020450 | 1.689 |
| R-HSA-9607240 | FLT3 Signaling | 0.018264 | 1.738 |
| R-HSA-165159 | MTOR signalling | 0.019710 | 1.705 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.019710 | 1.705 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.017938 | 1.746 |
| R-HSA-8865999 | MET activates PTPN11 | 0.021200 | 1.674 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 0.033707 | 1.472 |
| R-HSA-9645135 | STAT5 Activation | 0.037840 | 1.422 |
| R-HSA-9732724 | IFNG signaling activates MAPKs | 0.041957 | 1.377 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.066293 | 1.179 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.070290 | 1.153 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.082178 | 1.085 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.090020 | 1.046 |
| R-HSA-163210 | Formation of ATP by chemiosmotic coupling | 0.101660 | 0.993 |
| R-HSA-429947 | Deadenylation of mRNA | 0.120734 | 0.918 |
| R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse | 0.120734 | 0.918 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.131986 | 0.879 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.131986 | 0.879 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.135705 | 0.867 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.135705 | 0.867 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.143096 | 0.844 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.061826 | 1.209 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.061826 | 1.209 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.068851 | 1.162 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.074896 | 1.126 |
| R-HSA-192823 | Viral mRNA Translation | 0.086183 | 1.065 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.092662 | 1.033 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 0.070290 | 1.153 |
| R-HSA-156902 | Peptide chain elongation | 0.065306 | 1.185 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.142887 | 0.845 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 0.131986 | 0.879 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.076125 | 1.118 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.113152 | 0.946 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.077360 | 1.111 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.076125 | 1.118 |
| R-HSA-2424491 | DAP12 signaling | 0.143096 | 0.844 |
| R-HSA-525793 | Myogenesis | 0.128251 | 0.892 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.082365 | 1.084 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.040904 | 1.388 |
| R-HSA-165181 | Inhibition of TSC complex formation by PKB | 0.025386 | 1.595 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 0.033707 | 1.472 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.078232 | 1.107 |
| R-HSA-9702518 | STAT5 activation downstream of FLT3 ITD mutants | 0.086107 | 1.065 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.120734 | 0.918 |
| R-HSA-8949613 | Cristae formation | 0.131986 | 0.879 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.073674 | 1.133 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.076125 | 1.118 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.077360 | 1.111 |
| R-HSA-170968 | Frs2-mediated activation | 0.070290 | 1.153 |
| R-HSA-180292 | GAB1 signalosome | 0.093916 | 1.027 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.071249 | 1.147 |
| R-HSA-5654710 | PI-3K cascade:FGFR3 | 0.097796 | 1.010 |
| R-HSA-5654720 | PI-3K cascade:FGFR4 | 0.101660 | 0.993 |
| R-HSA-5654689 | PI-3K cascade:FGFR1 | 0.113152 | 0.946 |
| R-HSA-5654695 | PI-3K cascade:FGFR2 | 0.124500 | 0.905 |
| R-HSA-169893 | Prolonged ERK activation events | 0.082178 | 1.085 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.034178 | 1.466 |
| R-HSA-9762292 | Regulation of CDH11 function | 0.054202 | 1.266 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.132702 | 0.877 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.066481 | 1.177 |
| R-HSA-187706 | Signalling to p38 via RIT and RIN | 0.033707 | 1.472 |
| R-HSA-170984 | ARMS-mediated activation | 0.050138 | 1.300 |
| R-HSA-112411 | MAPK1 (ERK2) activation | 0.050138 | 1.300 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 0.078232 | 1.107 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 0.097796 | 1.010 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 0.105507 | 0.977 |
| R-HSA-5654706 | FRS-mediated FGFR3 signaling | 0.109338 | 0.961 |
| R-HSA-5654712 | FRS-mediated FGFR4 signaling | 0.113152 | 0.946 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 0.120734 | 0.918 |
| R-HSA-5654693 | FRS-mediated FGFR1 signaling | 0.124500 | 0.905 |
| R-HSA-420029 | Tight junction interactions | 0.124500 | 0.905 |
| R-HSA-5654700 | FRS-mediated FGFR2 signaling | 0.135705 | 0.867 |
| R-HSA-68877 | Mitotic Prometaphase | 0.063039 | 1.200 |
| R-HSA-202403 | TCR signaling | 0.096617 | 1.015 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.114282 | 0.942 |
| R-HSA-9028731 | Activated NTRK2 signals through FRS2 and FRS3 | 0.066293 | 1.179 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.143096 | 0.844 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.083632 | 1.078 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.038465 | 1.415 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.117070 | 0.932 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 0.082178 | 1.085 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.120734 | 0.918 |
| R-HSA-9669938 | Signaling by KIT in disease | 0.113152 | 0.946 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.069537 | 1.158 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 0.139408 | 0.856 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 0.143096 | 0.844 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.021965 | 1.658 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 0.025386 | 1.595 |
| R-HSA-9706374 | FLT3 signaling through SRC family kinases | 0.025386 | 1.595 |
| R-HSA-418886 | Netrin mediated repulsion signals | 0.041957 | 1.377 |
| R-HSA-110056 | MAPK3 (ERK1) activation | 0.054202 | 1.266 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 0.066293 | 1.179 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 0.066293 | 1.179 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 0.074269 | 1.129 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.087467 | 1.058 |
| R-HSA-190236 | Signaling by FGFR | 0.079850 | 1.098 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.055069 | 1.259 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.031084 | 1.507 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 0.050138 | 1.300 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.131986 | 0.879 |
| R-HSA-877300 | Interferon gamma signaling | 0.040707 | 1.390 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 0.033707 | 1.472 |
| R-HSA-164944 | Nef and signal transduction | 0.037840 | 1.422 |
| R-HSA-167590 | Nef Mediated CD4 Down-regulation | 0.041957 | 1.377 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.058250 | 1.235 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 0.109338 | 0.961 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.131986 | 0.879 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.095293 | 1.021 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.128391 | 0.891 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.093916 | 1.027 |
| R-HSA-162906 | HIV Infection | 0.089922 | 1.046 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.096617 | 1.015 |
| R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 0.033707 | 1.472 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 0.090020 | 1.046 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 0.113152 | 0.946 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 0.116951 | 0.932 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.021680 | 1.664 |
| R-HSA-202424 | Downstream TCR signaling | 0.067662 | 1.170 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.096617 | 1.015 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.115242 | 0.938 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.093975 | 1.027 |
| R-HSA-1059683 | Interleukin-6 signaling | 0.070290 | 1.153 |
| R-HSA-1170546 | Prolactin receptor signaling | 0.074269 | 1.129 |
| R-HSA-392517 | Rap1 signalling | 0.097796 | 1.010 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.139408 | 0.856 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.082178 | 1.085 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.113152 | 0.946 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.106027 | 0.975 |
| R-HSA-168255 | Influenza Infection | 0.053532 | 1.271 |
| R-HSA-9683610 | Maturation of nucleoprotein | 0.070290 | 1.153 |
| R-HSA-2586552 | Signaling by Leptin | 0.054202 | 1.266 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.128251 | 0.892 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.135661 | 0.868 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.050138 | 1.300 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 0.116951 | 0.932 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.036826 | 1.434 |
| R-HSA-109582 | Hemostasis | 0.056608 | 1.247 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 0.139408 | 0.856 |
| R-HSA-6783589 | Interleukin-6 family signaling | 0.120734 | 0.918 |
| R-HSA-373753 | Nephrin family interactions | 0.101660 | 0.993 |
| R-HSA-168256 | Immune System | 0.079059 | 1.102 |
| R-HSA-373760 | L1CAM interactions | 0.107391 | 0.969 |
| R-HSA-210993 | Tie2 Signaling | 0.093916 | 1.027 |
| R-HSA-9694631 | Maturation of nucleoprotein | 0.097796 | 1.010 |
| R-HSA-8854691 | Interleukin-20 family signaling | 0.116951 | 0.932 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.116951 | 0.932 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.086107 | 1.065 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 0.090020 | 1.046 |
| R-HSA-418346 | Platelet homeostasis | 0.091355 | 1.039 |
| R-HSA-9824446 | Viral Infection Pathways | 0.024043 | 1.619 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.024322 | 1.614 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.098362 | 1.007 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.087467 | 1.058 |
| R-HSA-1643685 | Disease | 0.053261 | 1.274 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.025130 | 1.600 |
| R-HSA-9020558 | Interleukin-2 signaling | 0.058250 | 1.235 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.131986 | 0.879 |
| R-HSA-449147 | Signaling by Interleukins | 0.058475 | 1.233 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.101963 | 0.992 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.068068 | 1.167 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.034711 | 1.460 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.034711 | 1.460 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.034711 | 1.460 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.034711 | 1.460 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.110133 | 0.958 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.070278 | 1.153 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.034711 | 1.460 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.050721 | 1.295 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.057527 | 1.240 |
| R-HSA-9679506 | SARS-CoV Infections | 0.036963 | 1.432 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.062979 | 1.201 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.070046 | 1.155 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.144356 | 0.841 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.146768 | 0.833 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.146768 | 0.833 |
| R-HSA-5694530 | Cargo concentration in the ER | 0.146768 | 0.833 |
| R-HSA-186763 | Downstream signal transduction | 0.146768 | 0.833 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.150263 | 0.823 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.150425 | 0.823 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.152958 | 0.815 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.154066 | 0.812 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.154066 | 0.812 |
| R-HSA-354192 | Integrin signaling | 0.154066 | 0.812 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.154066 | 0.812 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.157692 | 0.802 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.157692 | 0.802 |
| R-HSA-199991 | Membrane Trafficking | 0.158933 | 0.799 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.159213 | 0.798 |
| R-HSA-166520 | Signaling by NTRKs | 0.159213 | 0.798 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.161303 | 0.792 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.161303 | 0.792 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.161303 | 0.792 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.164898 | 0.783 |
| R-HSA-187687 | Signalling to ERKs | 0.164898 | 0.783 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 0.164898 | 0.783 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 0.164898 | 0.783 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.164898 | 0.783 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.164898 | 0.783 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.168478 | 0.773 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.168478 | 0.773 |
| R-HSA-8853659 | RET signaling | 0.168478 | 0.773 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.172043 | 0.764 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.172043 | 0.764 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.172043 | 0.764 |
| R-HSA-162587 | HIV Life Cycle | 0.172819 | 0.762 |
| R-HSA-9711097 | Cellular response to starvation | 0.174343 | 0.759 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.174343 | 0.759 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.175593 | 0.755 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.179128 | 0.747 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.179128 | 0.747 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.179128 | 0.747 |
| R-HSA-201556 | Signaling by ALK | 0.179128 | 0.747 |
| R-HSA-597592 | Post-translational protein modification | 0.179277 | 0.746 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.182648 | 0.738 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.182648 | 0.738 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.182648 | 0.738 |
| R-HSA-167169 | HIV Transcription Elongation | 0.182648 | 0.738 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.182648 | 0.738 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.182648 | 0.738 |
| R-HSA-5260271 | Diseases of Immune System | 0.182648 | 0.738 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.182648 | 0.738 |
| R-HSA-202433 | Generation of second messenger molecules | 0.182648 | 0.738 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.183532 | 0.736 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.183532 | 0.736 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.186153 | 0.730 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.186153 | 0.730 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.186153 | 0.730 |
| R-HSA-9683701 | Translation of Structural Proteins | 0.189643 | 0.722 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.194342 | 0.711 |
| R-HSA-5663205 | Infectious disease | 0.194438 | 0.711 |
| R-HSA-418555 | G alpha (s) signalling events | 0.195893 | 0.708 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.195893 | 0.708 |
| R-HSA-8854214 | TBC/RABGAPs | 0.196580 | 0.706 |
| R-HSA-2172127 | DAP12 interactions | 0.200026 | 0.699 |
| R-HSA-373752 | Netrin-1 signaling | 0.200026 | 0.699 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.202114 | 0.694 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.202773 | 0.693 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.203458 | 0.692 |
| R-HSA-774815 | Nucleosome assembly | 0.203458 | 0.692 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.203458 | 0.692 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.203458 | 0.692 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.203458 | 0.692 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.206875 | 0.684 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.206875 | 0.684 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 0.206875 | 0.684 |
| R-HSA-75153 | Apoptotic execution phase | 0.206875 | 0.684 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.210278 | 0.677 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.213666 | 0.670 |
| R-HSA-9766229 | Degradation of CDH1 | 0.217040 | 0.663 |
| R-HSA-109704 | PI3K Cascade | 0.220400 | 0.657 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.222482 | 0.653 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.223745 | 0.650 |
| R-HSA-2514856 | The phototransduction cascade | 0.223745 | 0.650 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.227076 | 0.644 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.227209 | 0.644 |
| R-HSA-74160 | Gene expression (Transcription) | 0.228373 | 0.641 |
| R-HSA-212436 | Generic Transcription Pathway | 0.229324 | 0.640 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.230394 | 0.638 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.230394 | 0.638 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.231578 | 0.635 |
| R-HSA-72649 | Translation initiation complex formation | 0.233697 | 0.631 |
| R-HSA-392499 | Metabolism of proteins | 0.235108 | 0.629 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.240262 | 0.619 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.240262 | 0.619 |
| R-HSA-177929 | Signaling by EGFR | 0.240262 | 0.619 |
| R-HSA-75893 | TNF signaling | 0.240262 | 0.619 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.240262 | 0.619 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.241432 | 0.617 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.243523 | 0.613 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.243523 | 0.613 |
| R-HSA-112399 | IRS-mediated signalling | 0.243523 | 0.613 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.246771 | 0.608 |
| R-HSA-68886 | M Phase | 0.248933 | 0.604 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.250005 | 0.602 |
| R-HSA-191859 | snRNP Assembly | 0.250005 | 0.602 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.250005 | 0.602 |
| R-HSA-8873719 | RAB geranylgeranylation | 0.253225 | 0.596 |
| R-HSA-983189 | Kinesins | 0.253225 | 0.596 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.253225 | 0.596 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.256432 | 0.591 |
| R-HSA-450294 | MAP kinase activation | 0.256432 | 0.591 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.256432 | 0.591 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.259625 | 0.586 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.259625 | 0.586 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.259625 | 0.586 |
| R-HSA-186797 | Signaling by PDGF | 0.259625 | 0.586 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.262804 | 0.580 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.262804 | 0.580 |
| R-HSA-373755 | Semaphorin interactions | 0.262804 | 0.580 |
| R-HSA-5690714 | CD22 mediated BCR regulation | 0.265970 | 0.575 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.265970 | 0.575 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.265970 | 0.575 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.265970 | 0.575 |
| R-HSA-68882 | Mitotic Anaphase | 0.268400 | 0.571 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.269123 | 0.570 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.269988 | 0.569 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.272262 | 0.565 |
| R-HSA-196807 | Nicotinate metabolism | 0.275388 | 0.560 |
| R-HSA-8951664 | Neddylation | 0.276340 | 0.559 |
| R-HSA-167172 | Transcription of the HIV genome | 0.278501 | 0.555 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.278501 | 0.555 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.282116 | 0.550 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.284687 | 0.546 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.284687 | 0.546 |
| R-HSA-448424 | Interleukin-17 signaling | 0.284687 | 0.546 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.284687 | 0.546 |
| R-HSA-2262752 | Cellular responses to stress | 0.285671 | 0.544 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.290821 | 0.536 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.290821 | 0.536 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 0.290821 | 0.536 |
| R-HSA-72312 | rRNA processing | 0.293792 | 0.532 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.293869 | 0.532 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.293869 | 0.532 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.295394 | 0.530 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.296903 | 0.527 |
| R-HSA-380287 | Centrosome maturation | 0.299925 | 0.523 |
| R-HSA-72766 | Translation | 0.303605 | 0.518 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.305930 | 0.514 |
| R-HSA-157118 | Signaling by NOTCH | 0.306456 | 0.514 |
| R-HSA-9659379 | Sensory processing of sound | 0.311884 | 0.506 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.312088 | 0.506 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.314843 | 0.502 |
| R-HSA-9833482 | PKR-mediated signaling | 0.314843 | 0.502 |
| R-HSA-6806834 | Signaling by MET | 0.314843 | 0.502 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.320722 | 0.494 |
| R-HSA-421270 | Cell-cell junction organization | 0.323802 | 0.490 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.326551 | 0.486 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.334790 | 0.475 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.335202 | 0.475 |
| R-HSA-6798695 | Neutrophil degranulation | 0.336543 | 0.473 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.340909 | 0.467 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.346567 | 0.460 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.354966 | 0.450 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.354966 | 0.450 |
| R-HSA-168249 | Innate Immune System | 0.357502 | 0.447 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.357741 | 0.446 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.363257 | 0.440 |
| R-HSA-446728 | Cell junction organization | 0.365890 | 0.437 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.368726 | 0.433 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.371444 | 0.430 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.374149 | 0.427 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.374149 | 0.427 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.374149 | 0.427 |
| R-HSA-70171 | Glycolysis | 0.379527 | 0.421 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.382198 | 0.418 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.384858 | 0.415 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.395386 | 0.403 |
| R-HSA-211000 | Gene Silencing by RNA | 0.400583 | 0.397 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.403165 | 0.395 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.403165 | 0.395 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.405737 | 0.392 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.413385 | 0.384 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.415912 | 0.381 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.423431 | 0.373 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.423431 | 0.373 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.425916 | 0.371 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.429290 | 0.367 |
| R-HSA-70326 | Glucose metabolism | 0.430855 | 0.366 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.430855 | 0.366 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.430855 | 0.366 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.435751 | 0.361 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.435751 | 0.361 |
| R-HSA-68875 | Mitotic Prophase | 0.438184 | 0.358 |
| R-HSA-73886 | Chromosome Maintenance | 0.440606 | 0.356 |
| R-HSA-3371556 | Cellular response to heat stress | 0.440606 | 0.356 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.443019 | 0.354 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.443019 | 0.354 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.445420 | 0.351 |
| R-HSA-194138 | Signaling by VEGF | 0.452565 | 0.344 |
| R-HSA-114608 | Platelet degranulation | 0.457277 | 0.340 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.459618 | 0.338 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.462534 | 0.335 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.473458 | 0.325 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.482490 | 0.317 |
| R-HSA-6807070 | PTEN Regulation | 0.489164 | 0.311 |
| R-HSA-1632852 | Macroautophagy | 0.493565 | 0.307 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.502257 | 0.299 |
| R-HSA-8953854 | Metabolism of RNA | 0.502955 | 0.298 |
| R-HSA-2187338 | Visual phototransduction | 0.508679 | 0.294 |
| R-HSA-73887 | Death Receptor Signaling | 0.523349 | 0.281 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.523349 | 0.281 |
| R-HSA-9612973 | Autophagy | 0.527460 | 0.278 |
| R-HSA-9610379 | HCMV Late Events | 0.529502 | 0.276 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.535578 | 0.271 |
| R-HSA-109581 | Apoptosis | 0.539585 | 0.268 |
| R-HSA-5619102 | SLC transporter disorders | 0.549455 | 0.260 |
| R-HSA-72306 | tRNA processing | 0.557201 | 0.254 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.562924 | 0.250 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.562924 | 0.250 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.562924 | 0.250 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.566699 | 0.247 |
| R-HSA-2559583 | Cellular Senescence | 0.575995 | 0.240 |
| R-HSA-69275 | G2/M Transition | 0.586892 | 0.231 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.590463 | 0.229 |
| R-HSA-983712 | Ion channel transport | 0.592237 | 0.228 |
| R-HSA-5617833 | Cilium Assembly | 0.594003 | 0.226 |
| R-HSA-9609690 | HCMV Early Events | 0.604444 | 0.219 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.604444 | 0.219 |
| R-HSA-1640170 | Cell Cycle | 0.609539 | 0.215 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.616290 | 0.210 |
| R-HSA-1266738 | Developmental Biology | 0.617998 | 0.209 |
| R-HSA-5357801 | Programmed Cell Death | 0.621260 | 0.207 |
| R-HSA-397014 | Muscle contraction | 0.632610 | 0.199 |
| R-HSA-418990 | Adherens junctions interactions | 0.642071 | 0.192 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.654314 | 0.184 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.660279 | 0.180 |
| R-HSA-15869 | Metabolism of nucleotides | 0.669038 | 0.175 |
| R-HSA-8939211 | ESR-mediated signaling | 0.670476 | 0.174 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.684521 | 0.165 |
| R-HSA-9609646 | HCMV Infection | 0.688618 | 0.162 |
| R-HSA-5688426 | Deubiquitination | 0.695331 | 0.158 |
| R-HSA-416476 | G alpha (q) signalling events | 0.707056 | 0.151 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.725618 | 0.139 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.764368 | 0.117 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.773635 | 0.111 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.790798 | 0.102 |
| R-HSA-73894 | DNA Repair | 0.807525 | 0.093 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.810042 | 0.091 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.810874 | 0.091 |
| R-HSA-388396 | GPCR downstream signalling | 0.860686 | 0.065 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.873861 | 0.059 |
| R-HSA-372790 | Signaling by GPCR | 0.895999 | 0.048 |
| R-HSA-9709957 | Sensory Perception | 0.974998 | 0.011 |
| R-HSA-382551 | Transport of small molecules | 0.988120 | 0.005 |
| R-HSA-1430728 | Metabolism | 0.999591 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CLK3 |
0.771 | 0.234 | 1 | 0.850 |
COT |
0.770 | 0.192 | 2 | 0.812 |
CDC7 |
0.755 | 0.067 | 1 | 0.817 |
TGFBR2 |
0.755 | 0.159 | -2 | 0.783 |
BMPR1B |
0.755 | 0.245 | 1 | 0.781 |
MOS |
0.755 | 0.084 | 1 | 0.832 |
PIM3 |
0.753 | 0.066 | -3 | 0.647 |
DSTYK |
0.753 | 0.109 | 2 | 0.804 |
NEK6 |
0.752 | 0.141 | -2 | 0.723 |
CDK5 |
0.752 | 0.177 | 1 | 0.746 |
BMPR2 |
0.749 | 0.105 | -2 | 0.746 |
TGFBR1 |
0.748 | 0.205 | -2 | 0.787 |
NLK |
0.748 | 0.092 | 1 | 0.810 |
GCN2 |
0.747 | 0.042 | 2 | 0.752 |
ACVR2B |
0.747 | 0.207 | -2 | 0.765 |
ACVR2A |
0.746 | 0.200 | -2 | 0.765 |
NDR2 |
0.746 | 0.023 | -3 | 0.662 |
CDK1 |
0.746 | 0.164 | 1 | 0.700 |
PRPK |
0.746 | -0.095 | -1 | 0.708 |
NEK7 |
0.745 | 0.078 | -3 | 0.657 |
CDK2 |
0.745 | 0.191 | 1 | 0.768 |
ATR |
0.745 | 0.055 | 1 | 0.811 |
CHAK2 |
0.745 | 0.081 | -1 | 0.727 |
CAMK1B |
0.744 | -0.005 | -3 | 0.644 |
BMPR1A |
0.744 | 0.242 | 1 | 0.775 |
ALK4 |
0.744 | 0.175 | -2 | 0.788 |
GRK1 |
0.743 | 0.080 | -2 | 0.625 |
CDK3 |
0.743 | 0.200 | 1 | 0.650 |
MLK1 |
0.743 | 0.039 | 2 | 0.778 |
AURC |
0.742 | 0.108 | -2 | 0.605 |
PKCD |
0.742 | 0.091 | 2 | 0.756 |
PRKD1 |
0.741 | 0.020 | -3 | 0.620 |
NDR1 |
0.741 | 0.015 | -3 | 0.635 |
PIM1 |
0.741 | 0.036 | -3 | 0.582 |
ULK2 |
0.741 | -0.002 | 2 | 0.760 |
ALK2 |
0.740 | 0.176 | -2 | 0.784 |
TSSK2 |
0.740 | 0.049 | -5 | 0.596 |
SRPK1 |
0.740 | 0.046 | -3 | 0.544 |
PKN3 |
0.740 | -0.007 | -3 | 0.614 |
SKMLCK |
0.740 | 0.030 | -2 | 0.700 |
CAMLCK |
0.739 | 0.023 | -2 | 0.715 |
KIS |
0.739 | 0.086 | 1 | 0.714 |
IKKA |
0.739 | 0.083 | -2 | 0.574 |
CDKL1 |
0.738 | -0.019 | -3 | 0.597 |
AMPKA1 |
0.738 | 0.030 | -3 | 0.643 |
ICK |
0.737 | 0.040 | -3 | 0.630 |
NUAK2 |
0.737 | -0.011 | -3 | 0.618 |
MLK2 |
0.737 | 0.045 | 2 | 0.801 |
NIK |
0.737 | -0.034 | -3 | 0.673 |
HIPK4 |
0.737 | 0.035 | 1 | 0.776 |
MTOR |
0.737 | -0.070 | 1 | 0.730 |
ERK5 |
0.737 | 0.003 | 1 | 0.730 |
TSSK1 |
0.737 | 0.043 | -3 | 0.662 |
CLK4 |
0.737 | 0.095 | -3 | 0.544 |
RSK2 |
0.736 | 0.007 | -3 | 0.554 |
MST4 |
0.736 | 0.021 | 2 | 0.819 |
DAPK2 |
0.736 | -0.000 | -3 | 0.651 |
CAMK2G |
0.736 | -0.078 | 2 | 0.730 |
LATS1 |
0.735 | 0.043 | -3 | 0.683 |
MLK3 |
0.735 | 0.062 | 2 | 0.722 |
RIPK3 |
0.735 | -0.038 | 3 | 0.663 |
CDK8 |
0.735 | 0.075 | 1 | 0.715 |
CLK1 |
0.735 | 0.094 | -3 | 0.506 |
PRKD2 |
0.735 | 0.012 | -3 | 0.535 |
ATM |
0.735 | 0.054 | 1 | 0.767 |
GRK7 |
0.735 | 0.079 | 1 | 0.737 |
IKKB |
0.735 | -0.066 | -2 | 0.576 |
GRK5 |
0.734 | -0.079 | -3 | 0.731 |
LATS2 |
0.734 | -0.017 | -5 | 0.479 |
TLK2 |
0.734 | 0.115 | 1 | 0.725 |
GRK6 |
0.734 | -0.005 | 1 | 0.788 |
MLK4 |
0.734 | 0.076 | 2 | 0.702 |
CDK18 |
0.734 | 0.112 | 1 | 0.673 |
HUNK |
0.733 | -0.053 | 2 | 0.769 |
RSK3 |
0.733 | -0.003 | -3 | 0.556 |
PDHK4 |
0.733 | -0.238 | 1 | 0.763 |
PKN2 |
0.733 | -0.015 | -3 | 0.621 |
AMPKA2 |
0.733 | 0.018 | -3 | 0.606 |
CDK7 |
0.733 | 0.072 | 1 | 0.724 |
PLK1 |
0.733 | 0.049 | -2 | 0.741 |
SRPK2 |
0.733 | 0.036 | -3 | 0.470 |
CLK2 |
0.733 | 0.101 | -3 | 0.537 |
ULK1 |
0.732 | -0.018 | -3 | 0.635 |
RAF1 |
0.732 | -0.136 | 1 | 0.740 |
PKR |
0.732 | 0.070 | 1 | 0.771 |
MARK4 |
0.732 | 0.035 | 4 | 0.708 |
P90RSK |
0.732 | -0.024 | -3 | 0.558 |
DLK |
0.731 | -0.024 | 1 | 0.762 |
NEK9 |
0.731 | -0.031 | 2 | 0.800 |
AURB |
0.731 | 0.084 | -2 | 0.606 |
ANKRD3 |
0.731 | -0.013 | 1 | 0.764 |
JNK3 |
0.731 | 0.103 | 1 | 0.689 |
CDKL5 |
0.731 | -0.028 | -3 | 0.588 |
P70S6KB |
0.730 | -0.017 | -3 | 0.572 |
NUAK1 |
0.730 | 0.015 | -3 | 0.567 |
JNK2 |
0.730 | 0.106 | 1 | 0.657 |
P38G |
0.729 | 0.109 | 1 | 0.618 |
MAPKAPK2 |
0.729 | -0.012 | -3 | 0.529 |
IRE2 |
0.729 | 0.020 | 2 | 0.698 |
IRE1 |
0.729 | -0.025 | 1 | 0.723 |
CDK17 |
0.729 | 0.102 | 1 | 0.636 |
CDK19 |
0.729 | 0.069 | 1 | 0.683 |
MNK2 |
0.729 | 0.042 | -2 | 0.672 |
MEK1 |
0.729 | 0.016 | 2 | 0.825 |
PKACG |
0.729 | 0.008 | -2 | 0.622 |
GRK4 |
0.728 | -0.028 | -2 | 0.682 |
TBK1 |
0.728 | -0.111 | 1 | 0.601 |
PKCB |
0.728 | 0.028 | 2 | 0.709 |
CDK13 |
0.728 | 0.069 | 1 | 0.693 |
CHK1 |
0.728 | 0.002 | -3 | 0.661 |
RSK4 |
0.727 | 0.020 | -3 | 0.537 |
PAK1 |
0.727 | 0.024 | -2 | 0.656 |
MAPKAPK3 |
0.726 | -0.055 | -3 | 0.563 |
IKKE |
0.726 | -0.115 | 1 | 0.595 |
PDHK1 |
0.726 | -0.231 | 1 | 0.732 |
WNK1 |
0.725 | -0.090 | -2 | 0.656 |
GRK2 |
0.725 | 0.023 | -2 | 0.596 |
PRKD3 |
0.725 | -0.017 | -3 | 0.510 |
PKACB |
0.725 | 0.052 | -2 | 0.608 |
SRPK3 |
0.724 | 0.003 | -3 | 0.526 |
PERK |
0.724 | 0.035 | -2 | 0.737 |
MASTL |
0.724 | -0.214 | -2 | 0.620 |
VRK2 |
0.724 | -0.079 | 1 | 0.799 |
CHAK1 |
0.724 | -0.013 | 2 | 0.768 |
CAMK2B |
0.724 | -0.032 | 2 | 0.693 |
MNK1 |
0.723 | 0.024 | -2 | 0.684 |
TLK1 |
0.723 | 0.045 | -2 | 0.747 |
AURA |
0.723 | 0.070 | -2 | 0.617 |
CAMK2D |
0.723 | -0.099 | -3 | 0.613 |
PRKX |
0.723 | 0.058 | -3 | 0.477 |
ERK2 |
0.722 | 0.081 | 1 | 0.677 |
P38A |
0.722 | 0.064 | 1 | 0.705 |
CAMK4 |
0.722 | -0.072 | -3 | 0.602 |
TTBK2 |
0.722 | -0.099 | 2 | 0.705 |
PKCG |
0.722 | -0.008 | 2 | 0.712 |
MYLK4 |
0.722 | 0.013 | -2 | 0.665 |
SMG1 |
0.721 | 0.012 | 1 | 0.768 |
AKT2 |
0.721 | 0.019 | -3 | 0.462 |
PLK3 |
0.721 | 0.019 | 2 | 0.695 |
CDK16 |
0.721 | 0.095 | 1 | 0.648 |
PAK3 |
0.721 | -0.015 | -2 | 0.651 |
MELK |
0.721 | -0.036 | -3 | 0.576 |
MSK2 |
0.721 | -0.023 | -3 | 0.549 |
SSTK |
0.721 | 0.070 | 4 | 0.662 |
NIM1 |
0.721 | -0.062 | 3 | 0.674 |
HIPK1 |
0.721 | 0.059 | 1 | 0.729 |
PKCA |
0.721 | 0.005 | 2 | 0.702 |
PKCZ |
0.720 | -0.007 | 2 | 0.745 |
CDK14 |
0.720 | 0.083 | 1 | 0.704 |
WNK3 |
0.720 | -0.163 | 1 | 0.723 |
ERK1 |
0.720 | 0.079 | 1 | 0.634 |
MSK1 |
0.720 | 0.010 | -3 | 0.555 |
HRI |
0.720 | -0.029 | -2 | 0.729 |
PKG2 |
0.720 | 0.029 | -2 | 0.589 |
YSK4 |
0.720 | -0.068 | 1 | 0.671 |
QSK |
0.719 | 0.028 | 4 | 0.698 |
P38B |
0.719 | 0.078 | 1 | 0.643 |
PHKG1 |
0.719 | -0.042 | -3 | 0.606 |
CDK12 |
0.719 | 0.059 | 1 | 0.665 |
FAM20C |
0.719 | 0.009 | 2 | 0.526 |
HIPK2 |
0.718 | 0.068 | 1 | 0.649 |
PINK1 |
0.718 | -0.008 | 1 | 0.811 |
DYRK2 |
0.718 | 0.032 | 1 | 0.710 |
PKCH |
0.718 | -0.021 | 2 | 0.694 |
DCAMKL1 |
0.718 | -0.024 | -3 | 0.561 |
CK1E |
0.718 | 0.012 | -3 | 0.545 |
CAMK2A |
0.717 | -0.059 | 2 | 0.708 |
RIPK1 |
0.717 | -0.172 | 1 | 0.726 |
GSK3A |
0.716 | 0.009 | 4 | 0.327 |
CDK9 |
0.716 | 0.042 | 1 | 0.694 |
P38D |
0.716 | 0.097 | 1 | 0.636 |
MEKK2 |
0.716 | 0.001 | 2 | 0.783 |
ZAK |
0.716 | -0.045 | 1 | 0.698 |
NEK5 |
0.716 | 0.005 | 1 | 0.739 |
PLK4 |
0.715 | -0.033 | 2 | 0.609 |
CAMK1G |
0.715 | -0.026 | -3 | 0.515 |
NEK2 |
0.714 | -0.079 | 2 | 0.779 |
MARK3 |
0.714 | 0.050 | 4 | 0.688 |
MARK2 |
0.714 | 0.041 | 4 | 0.656 |
GAK |
0.714 | 0.067 | 1 | 0.813 |
MEKK1 |
0.714 | -0.055 | 1 | 0.715 |
PAK2 |
0.714 | -0.019 | -2 | 0.643 |
PIM2 |
0.714 | -0.023 | -3 | 0.521 |
CDK10 |
0.714 | 0.069 | 1 | 0.696 |
PRP4 |
0.713 | 0.001 | -3 | 0.582 |
GSK3B |
0.713 | -0.030 | 4 | 0.318 |
BCKDK |
0.713 | -0.201 | -1 | 0.649 |
MPSK1 |
0.712 | 0.009 | 1 | 0.747 |
MEK5 |
0.712 | -0.126 | 2 | 0.799 |
DYRK1A |
0.712 | 0.017 | 1 | 0.751 |
DRAK1 |
0.712 | -0.047 | 1 | 0.764 |
GRK3 |
0.712 | 0.008 | -2 | 0.571 |
SIK |
0.712 | -0.015 | -3 | 0.534 |
DNAPK |
0.712 | -0.012 | 1 | 0.674 |
PAK6 |
0.711 | 0.031 | -2 | 0.608 |
DCAMKL2 |
0.711 | -0.038 | -3 | 0.571 |
EEF2K |
0.711 | 0.056 | 3 | 0.786 |
PKACA |
0.711 | 0.030 | -2 | 0.575 |
SGK3 |
0.711 | -0.029 | -3 | 0.559 |
QIK |
0.711 | -0.087 | -3 | 0.605 |
BRAF |
0.710 | -0.058 | -4 | 0.688 |
MST2 |
0.710 | 0.045 | 1 | 0.695 |
AKT1 |
0.710 | 0.019 | -3 | 0.479 |
CK1D |
0.710 | 0.012 | -3 | 0.497 |
TAO3 |
0.710 | -0.013 | 1 | 0.718 |
PKCT |
0.710 | -0.006 | 2 | 0.707 |
NEK8 |
0.709 | -0.011 | 2 | 0.768 |
JNK1 |
0.709 | 0.072 | 1 | 0.672 |
MEKK3 |
0.709 | -0.106 | 1 | 0.706 |
MST3 |
0.709 | -0.038 | 2 | 0.791 |
IRAK4 |
0.709 | -0.067 | 1 | 0.707 |
CDK6 |
0.709 | 0.090 | 1 | 0.681 |
PLK2 |
0.709 | 0.096 | -3 | 0.786 |
SMMLCK |
0.708 | -0.029 | -3 | 0.591 |
PASK |
0.708 | -0.046 | -3 | 0.670 |
DYRK1B |
0.708 | 0.038 | 1 | 0.693 |
CAMKK1 |
0.708 | -0.033 | -2 | 0.613 |
DAPK3 |
0.707 | 0.021 | -3 | 0.573 |
BRSK1 |
0.707 | -0.060 | -3 | 0.569 |
MARK1 |
0.705 | -0.009 | 4 | 0.680 |
TTK |
0.705 | 0.123 | -2 | 0.761 |
CK1A2 |
0.705 | 0.002 | -3 | 0.491 |
CK2A2 |
0.705 | 0.018 | 1 | 0.737 |
BRSK2 |
0.705 | -0.075 | -3 | 0.584 |
OSR1 |
0.705 | 0.126 | 2 | 0.805 |
CAMK1D |
0.705 | -0.032 | -3 | 0.458 |
MAK |
0.705 | 0.055 | -2 | 0.564 |
CDK4 |
0.705 | 0.072 | 1 | 0.663 |
AKT3 |
0.704 | 0.024 | -3 | 0.414 |
TNIK |
0.704 | 0.028 | 3 | 0.803 |
LKB1 |
0.704 | -0.029 | -3 | 0.628 |
DYRK3 |
0.703 | 0.035 | 1 | 0.720 |
PKCE |
0.703 | 0.007 | 2 | 0.694 |
SNRK |
0.703 | -0.139 | 2 | 0.634 |
ERK7 |
0.703 | 0.002 | 2 | 0.480 |
CAMKK2 |
0.703 | -0.049 | -2 | 0.607 |
PKCI |
0.702 | -0.021 | 2 | 0.716 |
HIPK3 |
0.702 | 0.005 | 1 | 0.686 |
DYRK4 |
0.702 | 0.034 | 1 | 0.667 |
MRCKA |
0.701 | 0.014 | -3 | 0.529 |
CK1G1 |
0.701 | -0.019 | -3 | 0.539 |
TAK1 |
0.700 | -0.002 | 1 | 0.731 |
MINK |
0.700 | -0.012 | 1 | 0.666 |
HGK |
0.700 | -0.016 | 3 | 0.797 |
MST1 |
0.700 | 0.006 | 1 | 0.677 |
TAO2 |
0.700 | -0.078 | 2 | 0.797 |
P70S6K |
0.700 | -0.064 | -3 | 0.487 |
ROCK2 |
0.700 | 0.027 | -3 | 0.581 |
PHKG2 |
0.699 | -0.072 | -3 | 0.551 |
GCK |
0.699 | -0.047 | 1 | 0.700 |
MAPKAPK5 |
0.698 | -0.133 | -3 | 0.503 |
DAPK1 |
0.698 | -0.004 | -3 | 0.558 |
PDK1 |
0.697 | -0.084 | 1 | 0.700 |
MRCKB |
0.697 | 0.010 | -3 | 0.507 |
BUB1 |
0.697 | 0.003 | -5 | 0.491 |
WNK4 |
0.697 | -0.170 | -2 | 0.629 |
VRK1 |
0.697 | -0.069 | 2 | 0.773 |
NEK4 |
0.696 | -0.099 | 1 | 0.673 |
CAMK1A |
0.696 | -0.019 | -3 | 0.419 |
TTBK1 |
0.696 | -0.113 | 2 | 0.630 |
MOK |
0.696 | 0.027 | 1 | 0.705 |
NEK11 |
0.696 | -0.176 | 1 | 0.698 |
IRAK1 |
0.695 | -0.179 | -1 | 0.634 |
LOK |
0.695 | -0.032 | -2 | 0.591 |
NEK1 |
0.695 | -0.067 | 1 | 0.698 |
SGK1 |
0.694 | -0.018 | -3 | 0.410 |
DMPK1 |
0.694 | 0.030 | -3 | 0.517 |
PAK5 |
0.694 | -0.000 | -2 | 0.559 |
CK2A1 |
0.693 | -0.007 | 1 | 0.723 |
MAP3K15 |
0.693 | -0.113 | 1 | 0.676 |
PBK |
0.693 | 0.019 | 1 | 0.731 |
PAK4 |
0.692 | 0.014 | -2 | 0.588 |
BIKE |
0.692 | 0.058 | 1 | 0.709 |
LRRK2 |
0.692 | -0.137 | 2 | 0.787 |
PKN1 |
0.692 | -0.060 | -3 | 0.486 |
SLK |
0.691 | -0.037 | -2 | 0.532 |
MEK2 |
0.691 | -0.105 | 2 | 0.801 |
MEKK6 |
0.690 | -0.130 | 1 | 0.688 |
CHK2 |
0.689 | -0.059 | -3 | 0.401 |
KHS2 |
0.689 | -0.028 | 1 | 0.674 |
STK33 |
0.688 | -0.088 | 2 | 0.621 |
KHS1 |
0.688 | -0.060 | 1 | 0.645 |
HPK1 |
0.688 | -0.098 | 1 | 0.668 |
SBK |
0.687 | -0.042 | -3 | 0.342 |
CRIK |
0.686 | -0.013 | -3 | 0.487 |
YSK1 |
0.684 | -0.093 | 2 | 0.776 |
ROCK1 |
0.684 | 0.002 | -3 | 0.530 |
ALPHAK3 |
0.683 | -0.036 | -1 | 0.666 |
AAK1 |
0.682 | 0.086 | 1 | 0.621 |
MYO3A |
0.682 | -0.008 | 1 | 0.677 |
PKG1 |
0.680 | -0.010 | -2 | 0.533 |
MYO3B |
0.680 | -0.028 | 2 | 0.787 |
HASPIN |
0.679 | -0.049 | -1 | 0.520 |
NEK3 |
0.679 | -0.113 | 1 | 0.643 |
CK1A |
0.678 | -0.001 | -3 | 0.435 |
RIPK2 |
0.677 | -0.220 | 1 | 0.639 |
STLK3 |
0.677 | -0.019 | 1 | 0.652 |
YANK3 |
0.676 | -0.028 | 2 | 0.402 |
ASK1 |
0.670 | -0.155 | 1 | 0.668 |
PDHK3_TYR |
0.670 | 0.132 | 4 | 0.683 |
TAO1 |
0.665 | -0.121 | 1 | 0.617 |
PDHK4_TYR |
0.661 | 0.053 | 2 | 0.796 |
TESK1_TYR |
0.659 | -0.025 | 3 | 0.758 |
MAP2K6_TYR |
0.658 | 0.017 | -1 | 0.764 |
BMPR2_TYR |
0.658 | 0.026 | -1 | 0.740 |
TXK |
0.657 | 0.137 | 1 | 0.791 |
EPHA6 |
0.656 | 0.058 | -1 | 0.706 |
CK1G3 |
0.655 | -0.032 | -3 | 0.394 |
MAP2K4_TYR |
0.654 | -0.083 | -1 | 0.736 |
PKMYT1_TYR |
0.654 | -0.075 | 3 | 0.720 |
LIMK2_TYR |
0.654 | 0.014 | -3 | 0.686 |
PINK1_TYR |
0.651 | -0.089 | 1 | 0.775 |
BLK |
0.651 | 0.112 | -1 | 0.679 |
PDHK1_TYR |
0.651 | -0.052 | -1 | 0.763 |
MAP2K7_TYR |
0.650 | -0.178 | 2 | 0.795 |
EPHB4 |
0.649 | 0.004 | -1 | 0.691 |
CK1G2 |
0.649 | -0.020 | -3 | 0.466 |
ROS1 |
0.648 | -0.025 | 3 | 0.689 |
TYRO3 |
0.648 | -0.019 | 3 | 0.702 |
LCK |
0.647 | 0.068 | -1 | 0.674 |
FGR |
0.646 | -0.007 | 1 | 0.764 |
ITK |
0.646 | 0.035 | -1 | 0.673 |
LIMK1_TYR |
0.645 | -0.117 | 2 | 0.806 |
RET |
0.645 | -0.091 | 1 | 0.704 |
YANK2 |
0.645 | -0.056 | 2 | 0.422 |
YES1 |
0.644 | 0.005 | -1 | 0.663 |
JAK3 |
0.644 | -0.042 | 1 | 0.703 |
HCK |
0.643 | 0.002 | -1 | 0.675 |
FER |
0.643 | -0.034 | 1 | 0.789 |
CSF1R |
0.643 | -0.037 | 3 | 0.657 |
MST1R |
0.643 | -0.100 | 3 | 0.683 |
INSRR |
0.642 | -0.035 | 3 | 0.641 |
ABL2 |
0.642 | -0.017 | -1 | 0.646 |
TYK2 |
0.642 | -0.129 | 1 | 0.686 |
TNNI3K_TYR |
0.640 | 0.001 | 1 | 0.692 |
EPHA4 |
0.639 | -0.026 | 2 | 0.688 |
JAK2 |
0.638 | -0.128 | 1 | 0.683 |
BMX |
0.638 | 0.003 | -1 | 0.583 |
EPHB2 |
0.638 | 0.000 | -1 | 0.678 |
PDGFRB |
0.637 | -0.067 | 3 | 0.688 |
FGFR2 |
0.637 | -0.066 | 3 | 0.660 |
SRMS |
0.637 | -0.028 | 1 | 0.765 |
TNK2 |
0.637 | -0.037 | 3 | 0.629 |
DDR1 |
0.637 | -0.166 | 4 | 0.588 |
FYN |
0.636 | 0.046 | -1 | 0.647 |
ABL1 |
0.636 | -0.044 | -1 | 0.632 |
EPHB1 |
0.636 | -0.051 | 1 | 0.747 |
EPHB3 |
0.635 | -0.051 | -1 | 0.674 |
KIT |
0.635 | -0.068 | 3 | 0.659 |
MET |
0.635 | -0.037 | 3 | 0.645 |
TEK |
0.635 | -0.076 | 3 | 0.641 |
KDR |
0.635 | -0.070 | 3 | 0.623 |
NEK10_TYR |
0.633 | -0.064 | 1 | 0.581 |
FGFR1 |
0.633 | -0.069 | 3 | 0.634 |
MERTK |
0.632 | -0.037 | 3 | 0.618 |
TEC |
0.632 | -0.019 | -1 | 0.582 |
BTK |
0.631 | -0.069 | -1 | 0.628 |
AXL |
0.631 | -0.080 | 3 | 0.647 |
FLT3 |
0.631 | -0.095 | 3 | 0.680 |
WEE1_TYR |
0.630 | -0.072 | -1 | 0.606 |
LYN |
0.629 | -0.022 | 3 | 0.598 |
FLT1 |
0.628 | -0.072 | -1 | 0.720 |
JAK1 |
0.628 | -0.087 | 1 | 0.622 |
FRK |
0.628 | -0.028 | -1 | 0.696 |
TNK1 |
0.628 | -0.109 | 3 | 0.669 |
PTK2 |
0.628 | 0.047 | -1 | 0.673 |
EPHA7 |
0.628 | -0.042 | 2 | 0.698 |
FGFR3 |
0.627 | -0.075 | 3 | 0.637 |
PDGFRA |
0.626 | -0.153 | 3 | 0.689 |
ERBB2 |
0.626 | -0.093 | 1 | 0.696 |
SRC |
0.625 | -0.013 | -1 | 0.627 |
MATK |
0.624 | -0.050 | -1 | 0.585 |
INSR |
0.623 | -0.104 | 3 | 0.639 |
SYK |
0.623 | 0.016 | -1 | 0.669 |
EPHA8 |
0.623 | -0.024 | -1 | 0.664 |
FLT4 |
0.623 | -0.109 | 3 | 0.618 |
NTRK1 |
0.623 | -0.124 | -1 | 0.665 |
EGFR |
0.623 | -0.029 | 1 | 0.614 |
PTK6 |
0.622 | -0.132 | -1 | 0.582 |
EPHA3 |
0.622 | -0.103 | 2 | 0.666 |
EPHA1 |
0.622 | -0.096 | 3 | 0.628 |
NTRK3 |
0.621 | -0.087 | -1 | 0.620 |
ALK |
0.621 | -0.136 | 3 | 0.595 |
NTRK2 |
0.621 | -0.119 | 3 | 0.616 |
EPHA5 |
0.621 | -0.051 | 2 | 0.664 |
PTK2B |
0.618 | -0.054 | -1 | 0.590 |
DDR2 |
0.617 | -0.113 | 3 | 0.622 |
LTK |
0.617 | -0.138 | 3 | 0.600 |
CSK |
0.616 | -0.089 | 2 | 0.713 |
MUSK |
0.614 | -0.079 | 1 | 0.596 |
FGFR4 |
0.614 | -0.062 | -1 | 0.631 |
ERBB4 |
0.614 | -0.015 | 1 | 0.633 |
IGF1R |
0.611 | -0.091 | 3 | 0.578 |
EPHA2 |
0.611 | -0.048 | -1 | 0.643 |
ZAP70 |
0.605 | -0.033 | -1 | 0.596 |
FES |
0.595 | -0.108 | -1 | 0.545 |