Motif 858 (n=93)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A087WV96 | CYP3A7-CYP3A51P | T138 | ochoa | Cytochrome P450 3A (EC 1.14.14.-) | Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. {ECO:0000256|RuleBase:RU368049}. |
| O00161 | SNAP23 | T41 | ochoa | Synaptosomal-associated protein 23 (SNAP-23) (Vesicle-membrane fusion protein SNAP-23) | Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion. |
| O60281 | ZNF292 | T1017 | ochoa | Zinc finger protein 292 | May be involved in transcriptional regulation. |
| O75363 | BCAS1 | T317 | ochoa | Breast carcinoma-amplified sequence 1 (Amplified and overexpressed in breast cancer) (Novel amplified in breast cancer 1) | Required for myelination. {ECO:0000250|UniProtKB:Q80YN3}. |
| O95271 | TNKS | T839 | psp | Poly [ADP-ribose] polymerase tankyrase-1 (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 5) (ARTD5) (Poly [ADP-ribose] polymerase 5A) (Protein poly-ADP-ribosyltransferase tankyrase-1) (EC 2.4.2.-) (TNKS-1) (TRF1-interacting ankyrin-related ADP-ribose polymerase) (Tankyrase I) (Tankyrase-1) (TANK1) | Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking (PubMed:10988299, PubMed:11739745, PubMed:16076287, PubMed:19759537, PubMed:21478859, PubMed:22864114, PubMed:23622245, PubMed:25043379, PubMed:28619731). Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation (PubMed:19759537, PubMed:21478859). Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination (PubMed:21478859). Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length (PubMed:11739745). Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI (PubMed:22864114). May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles (PubMed:10988299). May be involved in spindle pole assembly through PARsylation of NUMA1 (PubMed:16076287). Stimulates 26S proteasome activity (PubMed:23622245). {ECO:0000269|PubMed:10988299, ECO:0000269|PubMed:11739745, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:19759537, ECO:0000269|PubMed:21478859, ECO:0000269|PubMed:22864114, ECO:0000269|PubMed:23622245, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:28619731}. |
| P06753 | TPM3 | T54 | ochoa | Tropomyosin alpha-3 chain (Gamma-tropomyosin) (Tropomyosin-3) (Tropomyosin-5) (hTM5) | Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. {ECO:0000250|UniProtKB:P09493}. |
| P07951 | TPM2 | T252 | ochoa | Tropomyosin beta chain (Beta-tropomyosin) (Tropomyosin-2) | Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization. {ECO:0000250|UniProtKB:P58774, ECO:0000250|UniProtKB:P58775}. |
| P08670 | VIM | T361 | ochoa | Vimentin | Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Plays a role in cell directional movement, orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Protects SCRIB from proteasomal degradation and facilitates its localization to intermediate filaments in a cell contact-mediated manner (By similarity). {ECO:0000250|UniProtKB:A0A8C0N8E3, ECO:0000250|UniProtKB:P31000}.; FUNCTION: Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. {ECO:0000269|PubMed:21746880}. |
| P08684 | CYP3A4 | T138 | ochoa | Cytochrome P450 3A4 (EC 1.14.14.1) (1,4-cineole 2-exo-monooxygenase) (1,8-cineole 2-exo-monooxygenase) (EC 1.14.14.56) (Albendazole monooxygenase (sulfoxide-forming)) (EC 1.14.14.73) (Albendazole sulfoxidase) (CYPIIIA3) (CYPIIIA4) (Cholesterol 25-hydroxylase) (Cytochrome P450 3A3) (Cytochrome P450 HLp) (Cytochrome P450 NF-25) (Cytochrome P450-PCN1) (Nifedipine oxidase) (Quinine 3-monooxygenase) (EC 1.14.14.55) | A cytochrome P450 monooxygenase involved in the metabolism of sterols, steroid hormones, retinoids and fatty acids (PubMed:10681376, PubMed:11093772, PubMed:11555828, PubMed:12865317, PubMed:14559847, PubMed:15373842, PubMed:15764715, PubMed:19965576, PubMed:20702771, PubMed:21490593, PubMed:21576599). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds (PubMed:12865317, PubMed:14559847, PubMed:15373842, PubMed:15764715, PubMed:21490593, PubMed:21576599, PubMed:2732228). Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C-16 position (PubMed:11555828, PubMed:12865317, PubMed:14559847). Plays a role in the metabolism of androgens, particularly in oxidative deactivation of testosterone (PubMed:15373842, PubMed:15764715, PubMed:22773874, PubMed:2732228). Metabolizes testosterone to less biologically active 2beta- and 6beta-hydroxytestosterones (PubMed:15373842, PubMed:15764715, PubMed:2732228). Contributes to the formation of hydroxycholesterols (oxysterols), particularly A-ring hydroxylated cholesterol at the C-4beta position, and side chain hydroxylated cholesterol at the C-25 position, likely contributing to cholesterol degradation and bile acid biosynthesis (PubMed:21576599). Catalyzes bisallylic hydroxylation of polyunsaturated fatty acids (PUFA) (PubMed:9435160). Catalyzes the epoxidation of double bonds of PUFA with a preference for the last double bond (PubMed:19965576). Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling (PubMed:20702771). Plays a role in the metabolism of retinoids. Displays high catalytic activity for oxidation of all-trans-retinol to all-trans-retinal, a rate-limiting step for the biosynthesis of all-trans-retinoic acid (atRA) (PubMed:10681376). Further metabolizes atRA toward 4-hydroxyretinoate and may play a role in hepatic atRA clearance (PubMed:11093772). Responsible for oxidative metabolism of xenobiotics. Acts as a 2-exo-monooxygenase for plant lipid 1,8-cineole (eucalyptol) (PubMed:11159812). Metabolizes the majority of the administered drugs. Catalyzes sulfoxidation of the anthelmintics albendazole and fenbendazole (PubMed:10759686). Hydroxylates antimalarial drug quinine (PubMed:8968357). Acts as a 1,4-cineole 2-exo-monooxygenase (PubMed:11695850). Also involved in vitamin D catabolism and calcium homeostasis. Catalyzes the inactivation of the active hormone calcitriol (1-alpha,25-dihydroxyvitamin D(3)) (PubMed:29461981). {ECO:0000269|PubMed:10681376, ECO:0000269|PubMed:10759686, ECO:0000269|PubMed:11093772, ECO:0000269|PubMed:11159812, ECO:0000269|PubMed:11555828, ECO:0000269|PubMed:11695850, ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:14559847, ECO:0000269|PubMed:15373842, ECO:0000269|PubMed:15764715, ECO:0000269|PubMed:19965576, ECO:0000269|PubMed:20702771, ECO:0000269|PubMed:21490593, ECO:0000269|PubMed:21576599, ECO:0000269|PubMed:22773874, ECO:0000269|PubMed:2732228, ECO:0000269|PubMed:29461981, ECO:0000269|PubMed:8968357, ECO:0000269|PubMed:9435160}. |
| P11055 | MYH3 | S1200 | ochoa | Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE) | Muscle contraction. |
| P11055 | MYH3 | T1776 | ochoa | Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE) | Muscle contraction. |
| P12882 | MYH1 | T992 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12882 | MYH1 | S1203 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12882 | MYH1 | T1779 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12883 | MYH7 | S1199 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P12883 | MYH7 | T1775 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P12956 | XRCC6 | T472 | ochoa | X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6) | Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Required for double-strand break repair and V(D)J recombination (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Also has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). It works in the 3'-5' direction (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Binding to DNA may be mediated by XRCC6 (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The XRCC5-XRRC6 dimer acts as a regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks (PubMed:20383123). 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined (PubMed:20383123). The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488). In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:12145306). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Negatively regulates apoptosis by interacting with BAX and sequestering it from the mitochondria (PubMed:15023334). Might have deubiquitination activity, acting on BAX (PubMed:18362350). {ECO:0000269|PubMed:11493912, ECO:0000269|PubMed:12145306, ECO:0000269|PubMed:15023334, ECO:0000269|PubMed:18362350, ECO:0000269|PubMed:20383123, ECO:0000269|PubMed:20493174, ECO:0000269|PubMed:2466842, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:7957065, ECO:0000269|PubMed:8621488, ECO:0000269|PubMed:9742108}. |
| P13533 | MYH6 | S1201 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P13533 | MYH6 | T1777 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P13535 | MYH8 | T991 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
| P13535 | MYH8 | T1778 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
| P15822 | HIVEP1 | T1268 | ochoa | Zinc finger protein 40 (Cirhin interaction protein) (CIRIP) (Gate keeper of apoptosis-activating protein) (GAAP) (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis. |
| P16615 | ATP2A2 | T441 | ochoa | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) (SR Ca(2+)-ATPase 2) (EC 7.2.2.10) (Calcium pump 2) (Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase) | This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (PubMed:12542527, PubMed:16402920). Involved in autophagy in response to starvation. Upon interaction with VMP1 and activation, controls ER-isolation membrane contacts for autophagosome formation (PubMed:28890335). Also modulates ER contacts with lipid droplets, mitochondria and endosomes (PubMed:28890335). In coordination with FLVCR2 mediates heme-stimulated switching from mitochondrial ATP synthesis to thermogenesis (By similarity). {ECO:0000250|UniProtKB:O55143, ECO:0000269|PubMed:12542527, ECO:0000269|PubMed:16402920, ECO:0000269|PubMed:28890335}.; FUNCTION: [Isoform 2]: Involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca(2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca(2+) signaling cascades that promote osteoclast differentiation and activation. {ECO:0000250|UniProtKB:O55143}. |
| P20815 | CYP3A5 | T138 | ochoa | Cytochrome P450 3A5 (EC 1.14.14.1) (CYPIIIA5) (Cytochrome P450-PCN3) | A cytochrome P450 monooxygenase involved in the metabolism of steroid hormones and vitamins (PubMed:10681376, PubMed:11093772, PubMed:12865317, PubMed:2732228). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds (PubMed:10681376, PubMed:11093772, PubMed:12865317, PubMed:2732228). Exhibits high catalytic activity for the formation of catechol estrogens from 17beta-estradiol (E2) and estrone (E1), namely 2-hydroxy E1 and E2 (PubMed:12865317). Catalyzes 6beta-hydroxylation of the steroid hormones testosterone, progesterone, and androstenedione (PubMed:2732228). Catalyzes the oxidative conversion of all-trans-retinol to all-trans-retinal, a rate-limiting step for the biosynthesis of all-trans-retinoic acid (atRA) (PubMed:10681376). Further metabolizes all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may play a role in hepatic atRA clearance (PubMed:11093772). Also involved in the oxidative metabolism of xenobiotics, including calcium channel blocking drug nifedipine and immunosuppressive drug cyclosporine (PubMed:2732228). {ECO:0000269|PubMed:10681376, ECO:0000269|PubMed:11093772, ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:2732228}. |
| P20929 | NEB | T4441 | ochoa | Nebulin | This giant muscle protein may be involved in maintaining the structural integrity of sarcomeres and the membrane system associated with the myofibrils. Binds and stabilize F-actin. |
| P24462 | CYP3A7 | T138 | ochoa | Cytochrome P450 3A7 (EC 1.14.14.1) (CYPIIIA7) (Cytochrome P450-HFLA) (P450HLp2) | A cytochrome P450 monooxygenase involved in the metabolism of steroid hormones and vitamins during embryogenesis (PubMed:11093772, PubMed:12865317, PubMed:14559847, PubMed:17178770, PubMed:9555064). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:11093772, PubMed:12865317, PubMed:14559847, PubMed:17178770, PubMed:9555064). Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes 3beta-hydroxyandrost-5-en-17-one (dehydroepiandrosterone, DHEA), a precursor in the biosynthesis of androgen and estrogen steroid hormones (PubMed:17178770, PubMed:9555064). Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1), particularly D-ring hydroxylated estrone at the C16-alpha position (PubMed:12865317, PubMed:14559847). Mainly hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may play a role in atRA clearance during fetal development (PubMed:11093772). Also involved in the oxidative metabolism of xenobiotics including anticonvulsants (PubMed:9555064). {ECO:0000269|PubMed:11093772, ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:14559847, ECO:0000269|PubMed:17178770, ECO:0000269|PubMed:9555064}. |
| P35251 | RFC1 | T1073 | ochoa | Replication factor C subunit 1 (Activator 1 140 kDa subunit) (A1 140 kDa subunit) (Activator 1 large subunit) (Activator 1 subunit 1) (DNA-binding protein PO-GA) (Replication factor C 140 kDa subunit) (RF-C 140 kDa subunit) (RFC140) (Replication factor C large subunit) | Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA (PubMed:9488738). This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Can bind single- or double-stranded DNA. {ECO:0000269|PubMed:8999859, ECO:0000269|PubMed:9488738}. |
| P35579 | MYH9 | T1313 | ochoa | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P35579 | MYH9 | T1657 | ochoa | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P35749 | MYH11 | T1386 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
| P37198 | NUP62 | T467 | ochoa | Nuclear pore glycoprotein p62 (62 kDa nucleoporin) (Nucleoporin Nup62) | Essential component of the nuclear pore complex (PubMed:1915414). The N-terminal is probably involved in nucleocytoplasmic transport (PubMed:1915414). The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of p62 to the pore complex (PubMed:1915414, PubMed:24107630). Plays a role in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation and spindle orientation (PubMed:24107630). It might be involved in protein recruitment to the centrosome after nuclear breakdown (PubMed:24107630). {ECO:0000269|PubMed:1915414, ECO:0000269|PubMed:24107630}. |
| P46940 | IQGAP1 | T1509 | ochoa | Ras GTPase-activating-like protein IQGAP1 (p195) | Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Recruited to the cell cortex by interaction with ILK which allows it to cooperate with its effector DIAPH1 to locally stabilize microtubules and allow stable insertion of caveolae into the plasma membrane (By similarity). Binds to activated CDC42 but does not stimulate its GTPase activity. Associates with calmodulin. May promote neurite outgrowth (PubMed:15695813). May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest (PubMed:20883816). {ECO:0000250|UniProtKB:Q9JKF1, ECO:0000269|PubMed:15695813, ECO:0000269|PubMed:20883816}. |
| P49368 | CCT3 | T512 | psp | T-complex protein 1 subunit gamma (TCP-1-gamma) (EC 3.6.1.-) (CCT-gamma) (Chaperonin containing T-complex polypeptide 1 subunit 3) (hTRiC5) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P67936 | TPM4 | T216 | ochoa | Tropomyosin alpha-4 chain (TM30p1) (Tropomyosin-4) | Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments (By similarity). Binds calcium (PubMed:1836432). Plays a role in platelet biogenesis. {ECO:0000250|UniProtKB:P09495, ECO:0000269|PubMed:1836432, ECO:0000269|PubMed:28134622, ECO:0000269|PubMed:35170221}. |
| P68871 | HBB | T88 | ochoa | Hemoglobin subunit beta (Beta-globin) (Hemoglobin beta chain) [Cleaved into: LVV-hemorphin-7; Spinorphin] | Involved in oxygen transport from the lung to the various peripheral tissues. {ECO:0000269|PubMed:28066926}.; FUNCTION: LVV-hemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure.; FUNCTION: [Spinorphin]: Functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation. |
| Q12906 | ILF3 | T592 | ochoa | Interleukin enhancer-binding factor 3 (Double-stranded RNA-binding protein 76) (DRBP76) (M-phase phosphoprotein 4) (MPP4) (Nuclear factor associated with dsRNA) (NFAR) (Nuclear factor of activated T-cells 90 kDa) (NF-AT-90) (Translational control protein 80) (TCP80) | RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs (PubMed:28625552). As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (PubMed:21123651, PubMed:34110282). Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs (PubMed:21123651, PubMed:28625552). {ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:21123651, ECO:0000269|PubMed:28625552, ECO:0000269|PubMed:9442054}.; FUNCTION: (Microbial infection) Plays a positive role in HIV-1 virus production by binding to and thereby stabilizing HIV-1 RNA, together with ILF3. {ECO:0000269|PubMed:26891316}. |
| Q12923 | PTPN13 | T216 | ochoa | Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1) (PTP-BAS) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (Protein-tyrosine phosphatase PTPL1) | Tyrosine phosphatase which negatively regulates FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317). {ECO:0000269|PubMed:15611135, ECO:0000269|PubMed:23604317}. |
| Q13416 | ORC2 | T258 | ochoa | Origin recognition complex subunit 2 | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3. {ECO:0000269|PubMed:22427655, ECO:0000269|PubMed:22935713}. |
| Q13554 | CAMK2B | T287 | ochoa|psp | Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle (PubMed:16690701). In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons (PubMed:29100089). Participates in the modulation of skeletal muscle function in response to exercise (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). Phosphorylates reticulophagy regulator RETREG1 at 'Ser-151' under endoplasmic reticulum stress conditions which enhances RETREG1 oligomerization and its membrane scission and reticulophagy activity (PubMed:31930741). {ECO:0000250|UniProtKB:P08413, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:29100089, ECO:0000269|PubMed:31930741}. |
| Q13555 | CAMK2G | T287 | ochoa|psp | Calcium/calmodulin-dependent protein kinase type II subunit gamma (CaM kinase II subunit gamma) (CaMK-II subunit gamma) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin (PubMed:16690701). In the central nervous system, it is involved in the regulation of neurite formation and arborization (PubMed:30184290). It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q923T9, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:30184290}. |
| Q13557 | CAMK2D | T287 | ochoa|psp | Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program (PubMed:17179159). Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis (PubMed:16690701). May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q6PHZ2, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:17179159}. |
| Q13586 | STIM1 | T665 | ochoa | Stromal interaction molecule 1 | Acts as a Ca(2+) sensor that gates two major inward rectifying Ca(2+) channels at the plasma membrane: Ca(2+) release-activated Ca(2+) (CRAC) channels and arachidonate-regulated Ca(2+)-selective (ARC) channels (PubMed:15866891, PubMed:16005298, PubMed:16208375, PubMed:16537481, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:18854159, PubMed:19182790, PubMed:19249086, PubMed:19622606, PubMed:19706554, PubMed:22464749, PubMed:24069340, PubMed:24351972, PubMed:24591628, PubMed:25326555, PubMed:26322679, PubMed:28219928, PubMed:32415068). Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates CRAC channel pore-forming subunits ORA1, ORA2 and ORAI3 to generate sustained and oscillatory Ca(2+) entry (PubMed:16208375, PubMed:16537481, PubMed:32415068). Involved in enamel formation (PubMed:24621671). {ECO:0000269|PubMed:15866891, ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16208375, ECO:0000269|PubMed:16537481, ECO:0000269|PubMed:16733527, ECO:0000269|PubMed:16766533, ECO:0000269|PubMed:16807233, ECO:0000269|PubMed:18854159, ECO:0000269|PubMed:19182790, ECO:0000269|PubMed:19249086, ECO:0000269|PubMed:19622606, ECO:0000269|PubMed:19706554, ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:24069340, ECO:0000269|PubMed:24351972, ECO:0000269|PubMed:24591628, ECO:0000269|PubMed:24621671, ECO:0000269|PubMed:25326555, ECO:0000269|PubMed:26322679, ECO:0000269|PubMed:28219928, ECO:0000269|PubMed:32415068}. |
| Q15149 | PLEC | T1282 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q4VCS5 | AMOT | T536 | psp | Angiomotin | Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions. Repressor of YAP1 and WWTR1/TAZ transcription of target genes, potentially via regulation of Hippo signaling-mediated phosphorylation of YAP1 which results in its recruitment to tight junctions (PubMed:21205866). {ECO:0000269|PubMed:11257124, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:21205866}. |
| Q5T5Y3 | CAMSAP1 | T1030 | ochoa | Calmodulin-regulated spectrin-associated protein 1 | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19508979, PubMed:21834987, PubMed:24117850, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and stabilizes microtubules (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation (PubMed:24486153, PubMed:24706919). Through interaction with spectrin may regulate neurite outgrowth (PubMed:24117850). {ECO:0000269|PubMed:19508979, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:24117850, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919}. |
| Q6ZSR9 | None | T185 | ochoa | Uncharacterized protein FLJ45252 | None |
| Q6ZV65 | FAM47E | T158 | ochoa | Protein FAM47E | Promotes histone methylation by localizing the arginine methyltransferase PRMT5 to chromatin. {ECO:0000269|PubMed:33376131}. |
| Q711Q0 | CEFIP | T293 | ochoa | Cardiac-enriched FHL2-interacting protein | Plays an important role in cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. {ECO:0000250|UniProtKB:M0RD54}. |
| Q7Z3S7 | CACNA2D4 | T509 | ochoa | Voltage-dependent calcium channel subunit alpha-2/delta-4 (Voltage-gated calcium channel subunit alpha-2/delta-4) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-4; Voltage-dependent calcium channel subunit delta-4] | The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. {ECO:0000269|PubMed:12181424}. |
| Q7Z6Z7 | HUWE1 | T655 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q8IZ83 | ALDH16A1 | T490 | ochoa | Aldehyde dehydrogenase family 16 member A1 | None |
| Q8NEY1 | NAV1 | T1170 | ochoa | Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) | May be involved in neuronal migration. {ECO:0000250}. |
| Q8NHV4 | NEDD1 | T88 | psp | Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1) (NEDD-1) | Required for mitosis progression. Promotes the nucleation of microtubules from the spindle. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19509060}. |
| Q8WWK9 | CKAP2 | T596 | ochoa|psp | Cytoskeleton-associated protein 2 (CTCL tumor antigen se20-10) (Tumor- and microtubule-associated protein) | Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner (By similarity). {ECO:0000250}. |
| Q8WXH0 | SYNE2 | T5876 | ochoa | Nesprin-2 (KASH domain-containing protein 2) (KASH2) (Nuclear envelope spectrin repeat protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE) (Synaptic nuclear envelope protein 2) (Syne-2) | Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (PubMed:34818527). Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. May be involved in nucleus-centrosome attachment. During interkinetic nuclear migration (INM) at G2 phase and nuclear migration in neural progenitors its LINC complex association with SUN1/2 and probable association with cytoplasmic dynein-dynactin motor complexes functions to pull the nucleus toward the centrosome; SYNE1 and SYNE2 may act redundantly. During INM at G1 phase mediates respective LINC complex association with kinesin to push the nucleus away from the centrosome. Involved in nuclear migration in retinal photoreceptor progenitors. Required for centrosome migration to the apical cell surface during early ciliogenesis. Facilitates the relaxation of mechanical stress imposed by compressive actin fibers at the rupture site through its nteraction with SYN2 (PubMed:34818527). {ECO:0000250|UniProtKB:Q6ZWQ0, ECO:0000269|PubMed:12118075, ECO:0000269|PubMed:18396275, ECO:0000269|PubMed:19596800, ECO:0000269|PubMed:20724637, ECO:0000269|PubMed:22945352, ECO:0000269|PubMed:34818527}. |
| Q93084 | ATP2A3 | T441 | ochoa | Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (SERCA3) (SR Ca(2+)-ATPase 3) (EC 7.2.2.10) (Calcium pump 3) | This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction. {ECO:0000269|PubMed:11956212, ECO:0000269|PubMed:15028735}. |
| Q96F24 | NRBF2 | T123 | ochoa | Nuclear receptor-binding factor 2 (NRBF-2) (Comodulator of PPAR and RXR) | May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro). {ECO:0000269|PubMed:15610520}.; FUNCTION: Involved in starvation-induced autophagy probably by its association with PI3K complex I (PI3KC3-C1). However, effects has been described variably. Involved in the induction of starvation-induced autophagy (PubMed:24785657). Stabilizes PI3KC3-C1 assembly and enhances ATG14-linked lipid kinase activity of PIK3C3 (By similarity). Proposed to negatively regulate basal and starvation-induced autophagy and to inhibit PIK3C3 activity by modulating interactions in PI3KC3-C1 (PubMed:25086043). May be involved in autophagosome biogenesis (PubMed:25086043). May play a role in neural progenitor cell survival during differentiation (By similarity). {ECO:0000250|UniProtKB:Q8VCQ3, ECO:0000269|PubMed:24785657, ECO:0000269|PubMed:25086043}. |
| Q99801 | NKX3-1 | T166 | psp | Homeobox protein Nkx-3.1 (Homeobox protein NK-3 homolog A) | Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. {ECO:0000269|PubMed:19462257}. |
| Q9BRK5 | SDF4 | T193 | ochoa | 45 kDa calcium-binding protein (Cab45) (Stromal cell-derived factor 4) (SDF-4) | May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment. {ECO:0000250}.; FUNCTION: Isoform 5 may be involved in the exocytosis of zymogens by pancreatic acini. |
| Q9BVL2 | NUP58 | T331 | ochoa | Nucleoporin p58/p45 (58 kDa nucleoporin) (Nucleoporin-like protein 1) | Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. {ECO:0000250|UniProtKB:P70581}. |
| Q9BZF9 | UACA | T1232 | ochoa | Uveal autoantigen with coiled-coil domains and ankyrin repeats | Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1 (By similarity). {ECO:0000250}.; FUNCTION: Modulates isoactin dynamics to regulate the morphological alterations required for cell growth and motility. Interaction with ARF6 may modulate cell shape and motility after injury. May be involved in multiple neurite formation (By similarity). {ECO:0000250|UniProtKB:Q8CGB3, ECO:0000250|UniProtKB:Q8HYY4}. |
| Q9H8T0 | AKTIP | T190 | psp | AKT-interacting protein (Ft1) (Fused toes protein homolog) | Component of the FTS/Hook/FHIP complex (FHF complex) (PubMed:32073997). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). {ECO:0000269|PubMed:14749367, ECO:0000269|PubMed:18799622, ECO:0000269|PubMed:32073997}. |
| Q9UHF7 | TRPS1 | T929 | ochoa | Zinc finger transcription factor Trps1 (Tricho-rhino-phalangeal syndrome type I protein) (Zinc finger protein GC79) | Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes. {ECO:0000269|PubMed:12885770, ECO:0000269|PubMed:17391059}. |
| Q9UKX2 | MYH2 | T994 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UKX2 | MYH2 | S1205 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UKX2 | MYH2 | T1781 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UKX3 | MYH13 | T1779 | ochoa | Myosin-13 (Myosin heavy chain 13) (Myosin heavy chain, skeletal muscle, extraocular) (MyHC-EO) (Myosin heavy chain, skeletal muscle, laryngeal) (MyHC-IIL) (Superfast myosin) | Fast twitching myosin mediating the high-velocity and low-tension contractions of specific striated muscles. {ECO:0000269|PubMed:23908353}. |
| Q9UQM7 | CAMK2A | T286 | ochoa|psp | Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in various processes, such as synaptic plasticity, neurotransmitter release and long-term potentiation (PubMed:14722083). Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development (PubMed:28130356). Also regulates the migration of developing neurons (PubMed:29100089). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378). Phosphorylates the transcription factor ETS1 in response to calcium signaling, thereby decreasing ETS1 affinity for DNA (By similarity). In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (PubMed:11972023). In response to interferon-beta (IFN-beta) stimulation, stimulates the JAK-STAT signaling pathway (PubMed:35568036). Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (By similarity). {ECO:0000250|UniProtKB:P11275, ECO:0000250|UniProtKB:P11798, ECO:0000269|PubMed:11972023, ECO:0000269|PubMed:23805378, ECO:0000269|PubMed:28130356, ECO:0000269|PubMed:29100089}. |
| Q9Y2F5 | ICE1 | T1252 | ochoa | Little elongation complex subunit 1 (Interactor of little elongator complex ELL subunit 1) | Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780). {ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23932780}. |
| Q9Y5X5 | NPFFR2 | T477 | psp | Neuropeptide FF receptor 2 (G-protein coupled receptor 74) (G-protein coupled receptor HLWAR77) (Neuropeptide G-protein coupled receptor) | Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. {ECO:0000269|PubMed:11024015}. |
| Q9Y623 | MYH4 | T992 | ochoa | Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) | Muscle contraction. |
| Q9Y623 | MYH4 | T1779 | ochoa | Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) | Muscle contraction. |
| P31948 | STIP1 | T243 | Sugiyama | Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop) (Renal carcinoma antigen NY-REN-11) (Transformation-sensitive protein IEF SSP 3521) | Acts as a co-chaperone for HSP90AA1 (PubMed:27353360). Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (By similarity). {ECO:0000250|UniProtKB:O35814, ECO:0000303|PubMed:27353360}. |
| O75116 | ROCK2 | T967 | Sugiyama | Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho kinase 2) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2) | Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation. {ECO:0000269|PubMed:10579722, ECO:0000269|PubMed:15699075, ECO:0000269|PubMed:16574662, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21147781}. |
| P20674 | COX5A | T105 | Sugiyama | Cytochrome c oxidase subunit 5A, mitochondrial (Cytochrome c oxidase polypeptide Va) | Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P00427}. |
| P13807 | GYS1 | T278 | PSP | Glycogen [starch] synthase, muscle (EC 2.4.1.11) (Glycogen synthase 1) | Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. {ECO:0000269|PubMed:35835870}. |
| P43490 | NAMPT | T179 | Sugiyama | Nicotinamide phosphoribosyltransferase (NAmPRTase) (Nampt) (EC 2.4.2.12) (Pre-B-cell colony-enhancing factor 1) (Pre-B cell-enhancing factor) (Visfatin) | Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity). {ECO:0000250|UniProtKB:Q99KQ4, ECO:0000269|PubMed:24130902}. |
| P10721 | KIT | T607 | Sugiyama | Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117) | Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1. {ECO:0000269|PubMed:10397721, ECO:0000269|PubMed:12444928, ECO:0000269|PubMed:12511554, ECO:0000269|PubMed:12878163, ECO:0000269|PubMed:17904548, ECO:0000269|PubMed:19265199, ECO:0000269|PubMed:21135090, ECO:0000269|PubMed:21640708, ECO:0000269|PubMed:7520444, ECO:0000269|PubMed:9528781}. |
| P16234 | PDGFRA | T611 | Sugiyama | Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a) | Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor. {ECO:0000269|PubMed:10734113, ECO:0000269|PubMed:10947961, ECO:0000269|PubMed:11297552, ECO:0000269|PubMed:12522257, ECO:0000269|PubMed:1646396, ECO:0000269|PubMed:17087943, ECO:0000269|PubMed:1709159, ECO:0000269|PubMed:17141222, ECO:0000269|PubMed:20972453, ECO:0000269|PubMed:21224473, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:2554309, ECO:0000269|PubMed:8188664, ECO:0000269|PubMed:8760137, ECO:0000269|PubMed:8943348}. |
| P49588 | AARS1 | T240 | Sugiyama | Alanine--tRNA ligase, cytoplasmic (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS) (Protein lactyltransferase AARS1) (EC 6.-.-.-) (Renal carcinoma antigen NY-REN-42) | Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala) (PubMed:27622773, PubMed:27911835, PubMed:28493438, PubMed:33909043). Also edits incorrectly charged tRNA(Ala) via its editing domain (PubMed:27622773, PubMed:27911835, PubMed:28493438, PubMed:29273753). In presence of high levels of lactate, also acts as a protein lactyltransferase that mediates lactylation of lysine residues in target proteins, such as TEAD1, TP53/p53 and YAP1 (PubMed:38512451, PubMed:38653238). Protein lactylation takes place in a two-step reaction: lactate is first activated by ATP to form lactate-AMP and then transferred to lysine residues of target proteins (PubMed:38512451, PubMed:38653238, PubMed:39322678). Acts as an inhibitor of TP53/p53 activity by catalyzing lactylation of TP53/p53 (PubMed:38653238). Acts as a positive regulator of the Hippo pathway by mediating lactylation of TEAD1 and YAP1 (PubMed:38512451). {ECO:0000269|PubMed:27622773, ECO:0000269|PubMed:27911835, ECO:0000269|PubMed:28493438, ECO:0000269|PubMed:29273753, ECO:0000269|PubMed:33909043, ECO:0000269|PubMed:38512451, ECO:0000269|PubMed:38653238, ECO:0000269|PubMed:39322678}. |
| P05455 | SSB | T120 | Sugiyama | Lupus La protein (La autoantigen) (La ribonucleoprotein) (Sjoegren syndrome type B antigen) (SS-B) | Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation (PubMed:2470590, PubMed:3192525). In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12384597). {ECO:0000269|PubMed:12384597, ECO:0000269|PubMed:2470590, ECO:0000269|PubMed:3192525}. |
| Q07065 | CKAP4 | T471 | Sugiyama | Cytoskeleton-associated protein 4 (63-kDa cytoskeleton-linking membrane protein) (Climp-63) (p63) | Mediates the anchoring of the endoplasmic reticulum to microtubules. {ECO:0000269|PubMed:15703217}.; FUNCTION: High-affinity epithelial cell surface receptor for the FZD8-related low molecular weight sialoglycopeptide APF/antiproliferative factor. Mediates the APF antiproliferative signaling within cells. {ECO:0000269|PubMed:17030514, ECO:0000269|PubMed:19144824}. |
| P35579 | MYH9 | S1376 | Sugiyama | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| O95786 | RIGI | T671 | EPSD|PSP | Antiviral innate immune response receptor RIG-I (ATP-dependent RNA helicase DDX58) (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (RNA sensor RIG-I) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I) | Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and pro-inflammatory cytokines (PubMed:15208624, PubMed:15708988, PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:17190814, PubMed:18636086, PubMed:19122199, PubMed:19211564, PubMed:24366338, PubMed:28469175, PubMed:29117565, PubMed:31006531, PubMed:34935440, PubMed:35263596, PubMed:36793726). Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments (PubMed:15208624, PubMed:15708988). The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms (PubMed:28469175, PubMed:31006531). Upon activation, associates with mitochondria antiviral signaling protein (MAVS/IPS1) that activates the IKK-related kinases TBK1 and IKBKE which in turn phosphorylate the interferon regulatory factors IRF3 and IRF7, activating transcription of antiviral immunological genes including the IFN-alpha and IFN-beta interferons (PubMed:28469175, PubMed:31006531). Ligands include 5'-triphosphorylated ssRNAs and dsRNAs but also short dsRNAs (<1 kb in length) (PubMed:15208624, PubMed:15708988, PubMed:19576794, PubMed:19609254, PubMed:21742966). In addition to the 5'-triphosphate moiety, blunt-end base pairing at the 5'-end of the RNA is very essential (PubMed:15208624, PubMed:15708988, PubMed:19576794, PubMed:19609254, PubMed:21742966). Overhangs at the non-triphosphorylated end of the dsRNA RNA have no major impact on its activity (PubMed:15208624, PubMed:15708988, PubMed:19576794, PubMed:19609254, PubMed:21742966). A 3'overhang at the 5'triphosphate end decreases and any 5'overhang at the 5' triphosphate end abolishes its activity (PubMed:15208624, PubMed:15708988, PubMed:19576794, PubMed:19609254, PubMed:21742966). Detects both positive and negative strand RNA viruses including members of the families Paramyxoviridae: Human respiratory syncytial virus and measles virus (MeV), Rhabdoviridae: vesicular stomatitis virus (VSV), Orthomyxoviridae: influenza A and B virus, Flaviviridae: Japanese encephalitis virus (JEV), hepatitis C virus (HCV), dengue virus (DENV) and west Nile virus (WNV) (PubMed:21616437, PubMed:21884169). It also detects rotaviruses and reoviruses (PubMed:21616437, PubMed:21884169). Detects and binds to SARS-CoV-2 RNAs which is inhibited by m6A RNA modifications (Ref.74). Also involved in antiviral signaling in response to viruses containing a dsDNA genome such as Epstein-Barr virus (EBV) (PubMed:19631370). Detects dsRNA produced from non-self dsDNA by RNA polymerase III, such as Epstein-Barr virus-encoded RNAs (EBERs). May play important roles in granulocyte production and differentiation, bacterial phagocytosis and in the regulation of cell migration. {ECO:0000269|PubMed:15208624, ECO:0000269|PubMed:15708988, ECO:0000269|PubMed:16125763, ECO:0000269|PubMed:16127453, ECO:0000269|PubMed:16153868, ECO:0000269|PubMed:17190814, ECO:0000269|PubMed:18636086, ECO:0000269|PubMed:19122199, ECO:0000269|PubMed:19211564, ECO:0000269|PubMed:19576794, ECO:0000269|PubMed:19609254, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:21742966, ECO:0000269|PubMed:24366338, ECO:0000269|PubMed:28469175, ECO:0000269|PubMed:29117565, ECO:0000269|PubMed:31006531, ECO:0000269|PubMed:34935440, ECO:0000269|PubMed:35263596, ECO:0000269|PubMed:36793726, ECO:0000269|Ref.74, ECO:0000303|PubMed:21616437, ECO:0000303|PubMed:21884169}. |
| Q12792 | TWF1 | T304 | Sugiyama | Twinfilin-1 (Protein A6) (Protein tyrosine kinase 9) | Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles (By similarity). {ECO:0000250}. |
| P19338 | NCL | T305 | Sugiyama | Nucleolin (Protein C23) | Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. {ECO:0000269|PubMed:10393184}. |
| P09874 | PARP1 | T397 | Sugiyama | Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)] | Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:17177976, PubMed:18055453, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:20388712, PubMed:21680843, PubMed:22582261, PubMed:23230272, PubMed:25043379, PubMed:26344098, PubMed:26626479, PubMed:26626480, PubMed:30104678, PubMed:31796734, PubMed:32028527, PubMed:32241924, PubMed:32358582, PubMed:33186521, PubMed:34465625, PubMed:34737271). Mediates glutamate, aspartate, serine, histidine or tyrosine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:19764761, PubMed:25043379, PubMed:28190768, PubMed:29954836, PubMed:35393539, PubMed:7852410, PubMed:9315851). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:33186521, PubMed:34874266). Specificity for the different amino acids is conferred by interacting factors, such as HPF1 and NMNAT1 (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 confers serine specificity by completing the PARP1 active site (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Also catalyzes tyrosine ADP-ribosylation of target proteins following interaction with HPF1 (PubMed:29954836, PubMed:30257210). Following interaction with NMNAT1, catalyzes glutamate and aspartate ADP-ribosylation of target proteins; NMNAT1 confers glutamate and aspartate specificity (By similarity). PARP1 initiates the repair of DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones (H2BS6ADPr and H3S10ADPr), thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272, PubMed:27067600, PubMed:34465625, PubMed:34874266). HPF1 initiates serine ADP-ribosylation but restricts the polymerase activity of PARP1 in order to limit the length of poly-ADP-ribose chains (PubMed:33683197, PubMed:34732825, PubMed:34795260). In addition to base excision repair (BER) pathway, also involved in double-strand breaks (DSBs) repair: together with TIMELESS, accumulates at DNA damage sites and promotes homologous recombination repair by mediating poly-ADP-ribosylation (PubMed:26344098, PubMed:30356214). Mediates the poly-ADP-ribosylation of a number of proteins, including itself, APLF, CHFR, RPA1 and NFAT5 (PubMed:17396150, PubMed:19764761, PubMed:24906880, PubMed:34049076). In addition to proteins, also able to ADP-ribosylate DNA: catalyzes ADP-ribosylation of DNA strand break termini containing terminal phosphates and a 2'-OH group in single- and double-stranded DNA, respectively (PubMed:27471034). Required for PARP9 and DTX3L recruitment to DNA damage sites (PubMed:23230272). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). PARP1-mediated DNA repair in neurons plays a role in sleep: senses DNA damage in neurons and promotes sleep, facilitating efficient DNA repair (By similarity). In addition to DNA repair, also involved in other processes, such as transcription regulation, programmed cell death, membrane repair, adipogenesis and innate immunity (PubMed:15607977, PubMed:17177976, PubMed:19344625, PubMed:27256882, PubMed:32315358, PubMed:32844745, PubMed:35124853, PubMed:35393539, PubMed:35460603). Acts as a repressor of transcription: binds to nucleosomes and modulates chromatin structure in a manner similar to histone H1, thereby altering RNA polymerase II (PubMed:15607977, PubMed:22464733). Acts both as a positive and negative regulator of transcription elongation, depending on the context (PubMed:27256882, PubMed:35393539). Acts as a positive regulator of transcription elongation by mediating poly-ADP-ribosylation of NELFE, preventing RNA-binding activity of NELFE and relieving transcription pausing (PubMed:27256882). Acts as a negative regulator of transcription elongation in response to DNA damage by catalyzing poly-ADP-ribosylation of CCNT1, disrupting the phase separation activity of CCNT1 and subsequent activation of CDK9 (PubMed:35393539). Involved in replication fork progression following interaction with CARM1: mediates poly-ADP-ribosylation at replication forks, slowing fork progression (PubMed:33412112). Poly-ADP-ribose chains generated by PARP1 also play a role in poly-ADP-ribose-dependent cell death, a process named parthanatos (By similarity). Also acts as a negative regulator of the cGAS-STING pathway (PubMed:32315358, PubMed:32844745, PubMed:35460603). Acts by mediating poly-ADP-ribosylation of CGAS: PARP1 translocates into the cytosol following phosphorylation by PRKDC and catalyzes poly-ADP-ribosylation and inactivation of CGAS (PubMed:35460603). Acts as a negative regulator of adipogenesis: catalyzes poly-ADP-ribosylation of histone H2B on 'Glu-35' (H2BE35ADPr) following interaction with NMNAT1, inhibiting phosphorylation of H2B at 'Ser-36' (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (By similarity). Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000250|UniProtKB:P11103, ECO:0000269|PubMed:15607977, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:17396150, ECO:0000269|PubMed:18055453, ECO:0000269|PubMed:18172500, ECO:0000269|PubMed:19344625, ECO:0000269|PubMed:19661379, ECO:0000269|PubMed:19764761, ECO:0000269|PubMed:20388712, ECO:0000269|PubMed:21680843, ECO:0000269|PubMed:22464733, ECO:0000269|PubMed:22582261, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:24906880, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:26344098, ECO:0000269|PubMed:26626479, ECO:0000269|PubMed:26626480, ECO:0000269|PubMed:27067600, ECO:0000269|PubMed:27256882, ECO:0000269|PubMed:27257257, ECO:0000269|PubMed:27471034, ECO:0000269|PubMed:28190768, ECO:0000269|PubMed:29954836, ECO:0000269|PubMed:30104678, ECO:0000269|PubMed:30257210, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:31796734, ECO:0000269|PubMed:32028527, ECO:0000269|PubMed:32241924, ECO:0000269|PubMed:32315358, ECO:0000269|PubMed:32358582, ECO:0000269|PubMed:32844745, ECO:0000269|PubMed:33186521, ECO:0000269|PubMed:33412112, ECO:0000269|PubMed:33589610, ECO:0000269|PubMed:33683197, ECO:0000269|PubMed:34049076, ECO:0000269|PubMed:34465625, ECO:0000269|PubMed:34625544, ECO:0000269|PubMed:34732825, ECO:0000269|PubMed:34737271, ECO:0000269|PubMed:34795260, ECO:0000269|PubMed:34874266, ECO:0000269|PubMed:35124853, ECO:0000269|PubMed:35393539, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:7852410, ECO:0000269|PubMed:9315851}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed C-terminus]: Promotes AIFM1-mediated apoptosis (PubMed:33168626). This form, which translocates into the cytoplasm following cleavage by caspase-3 (CASP3) and caspase-7 (CASP7) in response to apoptosis, is auto-poly-ADP-ribosylated and serves as a poly-ADP-ribose carrier to induce AIFM1-mediated apoptosis (PubMed:33168626). {ECO:0000269|PubMed:33168626}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed N-terminus]: This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis. {ECO:0000269|PubMed:35104452}. |
| Q9H2G2 | SLK | T527 | Sugiyama | STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2) | Mediates apoptosis and actin stress fiber dissolution. {ECO:0000250}. |
| P17275 | JUNB | T313 | Sugiyama | Transcription factor JunB (Transcription factor AP-1 subunit JunB) | Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[GC]TCA-3'. Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to an AP-1 consensus sequence and its transcriptional activity (By similarity). {ECO:0000250|UniProtKB:P09450}. |
| O60271 | SPAG9 | T423 | Sugiyama | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}. |
| Q9BYT3 | STK33 | T496 | Sugiyama | Serine/threonine-protein kinase 33 (EC 2.7.11.1) | Serine/threonine protein kinase required for spermatid differentiation and male fertility (PubMed:37146716, PubMed:38781365). Promotes sperm flagella assembly during spermatogenesis by mediating phosphorylation of fibrous sheath proteins AKAP3 and AKAP4 (By similarity). Also phosphorylates vimentin/VIM, thereby regulating the dynamic behavior of the intermediate filament cytoskeleton (By similarity). {ECO:0000250|UniProtKB:Q924X7, ECO:0000269|PubMed:37146716, ECO:0000269|PubMed:38781365}. |
| Q92888 | ARHGEF1 | T406 | Sugiyama | Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5) | Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits (PubMed:9641915, PubMed:9641916). Acts as a GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase (PubMed:30521495, PubMed:8810315, PubMed:9641915, PubMed:9641916). Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain (PubMed:9641916). This GEF activity is inhibited by binding to activated GNA12 (PubMed:9641916). Mediates angiotensin-2-induced RhoA activation (PubMed:20098430). In lymphoid follicles, may trigger activation of GNA13 as part of S1PR2-dependent signaling pathway that leads to inhibition of germinal center (GC) B cell growth and migration outside the GC niche. {ECO:0000250|UniProtKB:Q61210, ECO:0000269|PubMed:20098430, ECO:0000269|PubMed:30521495, ECO:0000269|PubMed:8810315, ECO:0000269|PubMed:9641915, ECO:0000269|PubMed:9641916}. |
| Q52LJ0 | FAM98B | T267 | Sugiyama | Protein FAM98B | Positively stimulates PRMT1-induced protein arginine dimethylated arginine methylation (PubMed:28040436). {ECO:0000269|PubMed:28040436}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-397014 | Muscle contraction | 7.671641e-13 | 12.115 |
| R-HSA-390522 | Striated Muscle Contraction | 1.582692e-10 | 9.801 |
| R-HSA-5578775 | Ion homeostasis | 1.370383e-07 | 6.863 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 1.329717e-06 | 5.876 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 3.749220e-06 | 5.426 |
| R-HSA-936837 | Ion transport by P-type ATPases | 5.249508e-06 | 5.280 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 2.321292e-05 | 4.634 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 2.321292e-05 | 4.634 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 1.266629e-05 | 4.897 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 2.011208e-05 | 4.697 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 2.011208e-05 | 4.697 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 2.011208e-05 | 4.697 |
| R-HSA-6802949 | Signaling by RAS mutants | 2.011208e-05 | 4.697 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 2.321292e-05 | 4.634 |
| R-HSA-3371556 | Cellular response to heat stress | 1.807939e-05 | 4.743 |
| R-HSA-5576891 | Cardiac conduction | 3.097158e-05 | 4.509 |
| R-HSA-9620244 | Long-term potentiation | 3.961086e-05 | 4.402 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 5.654001e-05 | 4.248 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 8.307243e-05 | 4.081 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 9.568096e-05 | 4.019 |
| R-HSA-399719 | Trafficking of AMPA receptors | 7.822082e-05 | 4.107 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 9.568096e-05 | 4.019 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 8.552595e-05 | 4.068 |
| R-HSA-9700206 | Signaling by ALK in cancer | 8.552595e-05 | 4.068 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 9.568096e-05 | 4.019 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 1.270785e-04 | 3.896 |
| R-HSA-111933 | Calmodulin induced events | 1.388506e-04 | 3.857 |
| R-HSA-111997 | CaM pathway | 1.388506e-04 | 3.857 |
| R-HSA-5673000 | RAF activation | 1.158125e-04 | 3.936 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 2.278386e-04 | 3.642 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 2.538940e-04 | 3.595 |
| R-HSA-111996 | Ca-dependent events | 2.458964e-04 | 3.609 |
| R-HSA-1489509 | DAG and IP3 signaling | 3.062423e-04 | 3.514 |
| R-HSA-3371571 | HSF1-dependent transactivation | 4.576746e-04 | 3.339 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 4.799376e-04 | 3.319 |
| R-HSA-445355 | Smooth Muscle Contraction | 5.182423e-04 | 3.285 |
| R-HSA-913531 | Interferon Signaling | 7.158398e-04 | 3.145 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 8.006697e-04 | 3.097 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 8.917437e-04 | 3.050 |
| R-HSA-6784531 | tRNA processing in the nucleus | 8.628042e-04 | 3.064 |
| R-HSA-112043 | PLC beta mediated events | 8.182408e-04 | 3.087 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 9.766484e-04 | 3.010 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 1.066508e-03 | 2.972 |
| R-HSA-112040 | G-protein mediated events | 1.111594e-03 | 2.954 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 1.261523e-03 | 2.899 |
| R-HSA-418360 | Platelet calcium homeostasis | 1.261523e-03 | 2.899 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 1.366891e-03 | 2.864 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 1.477635e-03 | 2.830 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 1.477635e-03 | 2.830 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 1.715650e-03 | 2.766 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 1.715650e-03 | 2.766 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 1.608124e-03 | 2.794 |
| R-HSA-983712 | Ion channel transport | 1.598482e-03 | 2.796 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 1.843113e-03 | 2.734 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 1.843113e-03 | 2.734 |
| R-HSA-180746 | Nuclear import of Rev protein | 1.976338e-03 | 2.704 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 2.038875e-03 | 2.691 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 2.115415e-03 | 2.675 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 2.411479e-03 | 2.618 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 2.081121e-03 | 2.682 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 2.417053e-03 | 2.617 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 2.731986e-03 | 2.564 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 2.901609e-03 | 2.537 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 2.901609e-03 | 2.537 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 2.901609e-03 | 2.537 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 3.077585e-03 | 2.512 |
| R-HSA-438064 | Post NMDA receptor activation events | 2.714140e-03 | 2.566 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 2.568635e-03 | 2.590 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 2.731986e-03 | 2.564 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 2.580462e-03 | 2.588 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 2.919176e-03 | 2.535 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 3.138517e-03 | 2.503 |
| R-HSA-418359 | Reduction of cytosolic Ca++ levels | 3.733071e-03 | 2.428 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 3.804457e-03 | 2.420 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 4.055328e-03 | 2.392 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 4.270940e-03 | 2.369 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 4.722755e-03 | 2.326 |
| R-HSA-9669937 | Drug resistance of KIT mutants | 5.944071e-03 | 2.226 |
| R-HSA-9674415 | Drug resistance of PDGFR mutants | 5.944071e-03 | 2.226 |
| R-HSA-9669921 | KIT mutants bind TKIs | 5.944071e-03 | 2.226 |
| R-HSA-9674428 | PDGFR mutants bind TKIs | 5.944071e-03 | 2.226 |
| R-HSA-9674404 | Sorafenib-resistant PDGFR mutants | 5.944071e-03 | 2.226 |
| R-HSA-9669924 | Masitinib-resistant KIT mutants | 5.944071e-03 | 2.226 |
| R-HSA-9669917 | Imatinib-resistant KIT mutants | 5.944071e-03 | 2.226 |
| R-HSA-9669926 | Nilotinib-resistant KIT mutants | 5.944071e-03 | 2.226 |
| R-HSA-9669929 | Regorafenib-resistant KIT mutants | 5.944071e-03 | 2.226 |
| R-HSA-9669934 | Sunitinib-resistant KIT mutants | 5.944071e-03 | 2.226 |
| R-HSA-9674403 | Regorafenib-resistant PDGFR mutants | 5.944071e-03 | 2.226 |
| R-HSA-9674396 | Imatinib-resistant PDGFR mutants | 5.944071e-03 | 2.226 |
| R-HSA-9674401 | Sunitinib-resistant PDGFR mutants | 5.944071e-03 | 2.226 |
| R-HSA-9669936 | Sorafenib-resistant KIT mutants | 5.944071e-03 | 2.226 |
| R-HSA-9669914 | Dasatinib-resistant KIT mutants | 5.944071e-03 | 2.226 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 4.826693e-03 | 2.316 |
| R-HSA-111885 | Opioid Signalling | 5.131287e-03 | 2.290 |
| R-HSA-162582 | Signal Transduction | 5.263764e-03 | 2.279 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 6.067591e-03 | 2.217 |
| R-HSA-5683057 | MAPK family signaling cascades | 6.521760e-03 | 2.186 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 6.813142e-03 | 2.167 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 7.107172e-03 | 2.148 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 7.149288e-03 | 2.146 |
| R-HSA-191859 | snRNP Assembly | 7.717579e-03 | 2.113 |
| R-HSA-194441 | Metabolism of non-coding RNA | 7.717579e-03 | 2.113 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 8.358068e-03 | 2.078 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 8.510063e-03 | 2.070 |
| R-HSA-373755 | Semaphorin interactions | 9.028956e-03 | 2.044 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 9.230541e-03 | 2.035 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 1.243153e-02 | 1.905 |
| R-HSA-211981 | Xenobiotics | 9.375894e-03 | 2.028 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 1.284893e-02 | 1.891 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 1.572171e-02 | 1.804 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 1.591303e-02 | 1.798 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 1.599463e-02 | 1.796 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 1.696589e-02 | 1.770 |
| R-HSA-9669935 | Signaling by juxtamembrane domain KIT mutants | 1.772752e-02 | 1.751 |
| R-HSA-9680187 | Signaling by extracellular domain mutants of KIT | 1.772752e-02 | 1.751 |
| R-HSA-5545619 | XAV939 stabilizes AXIN | 1.772752e-02 | 1.751 |
| R-HSA-9669933 | Signaling by kinase domain mutants of KIT | 1.772752e-02 | 1.751 |
| R-HSA-9615710 | Late endosomal microautophagy | 1.881892e-02 | 1.725 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 1.881892e-02 | 1.725 |
| R-HSA-9008059 | Interleukin-37 signaling | 1.983355e-02 | 1.703 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 2.028067e-02 | 1.693 |
| R-HSA-168256 | Immune System | 2.099083e-02 | 1.678 |
| R-HSA-162587 | HIV Life Cycle | 2.104702e-02 | 1.677 |
| R-HSA-877300 | Interferon gamma signaling | 2.183099e-02 | 1.661 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 2.193000e-02 | 1.659 |
| R-HSA-3814836 | Glycogen storage disease type XV (GYG1) | 2.356730e-02 | 1.628 |
| R-HSA-3828062 | Glycogen storage disease type 0 (muscle GYS1) | 2.356730e-02 | 1.628 |
| R-HSA-5696400 | Dual Incision in GG-NER | 2.523822e-02 | 1.598 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 2.523822e-02 | 1.598 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 3.368061e-02 | 1.473 |
| R-HSA-9734767 | Developmental Cell Lineages | 2.752937e-02 | 1.560 |
| R-HSA-5423646 | Aflatoxin activation and detoxification | 3.368061e-02 | 1.473 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 2.301122e-02 | 1.638 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 2.523822e-02 | 1.598 |
| R-HSA-168255 | Influenza Infection | 3.114724e-02 | 1.507 |
| R-HSA-70171 | Glycolysis | 2.912951e-02 | 1.536 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 2.873578e-02 | 1.542 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 3.047518e-02 | 1.516 |
| R-HSA-1643685 | Disease | 2.676552e-02 | 1.572 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 2.523822e-02 | 1.598 |
| R-HSA-2682334 | EPH-Ephrin signaling | 2.347634e-02 | 1.629 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 2.717186e-02 | 1.566 |
| R-HSA-72306 | tRNA processing | 2.690975e-02 | 1.570 |
| R-HSA-74160 | Gene expression (Transcription) | 2.501908e-02 | 1.602 |
| R-HSA-418346 | Platelet homeostasis | 3.398075e-02 | 1.469 |
| R-HSA-211000 | Gene Silencing by RNA | 3.470600e-02 | 1.460 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 3.626870e-02 | 1.440 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 3.792697e-02 | 1.421 |
| R-HSA-1483249 | Inositol phosphate metabolism | 3.845214e-02 | 1.415 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 3.893108e-02 | 1.410 |
| R-HSA-75153 | Apoptotic execution phase | 4.166564e-02 | 1.380 |
| R-HSA-70326 | Glucose metabolism | 4.402914e-02 | 1.356 |
| R-HSA-68875 | Mitotic Prophase | 4.653647e-02 | 1.332 |
| R-HSA-68689 | CDC6 association with the ORC:origin complex | 4.658483e-02 | 1.332 |
| R-HSA-389397 | Orexin and neuropeptides FF and QRFP bind to their respective receptors | 4.658483e-02 | 1.332 |
| R-HSA-162909 | Host Interactions of HIV factors | 4.998742e-02 | 1.301 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 5.028223e-02 | 1.299 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 5.053802e-02 | 1.296 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 5.225481e-02 | 1.282 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 5.635105e-02 | 1.249 |
| R-HSA-162906 | HIV Infection | 6.079664e-02 | 1.216 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 6.151722e-02 | 1.211 |
| R-HSA-446107 | Type I hemidesmosome assembly | 6.349484e-02 | 1.197 |
| R-HSA-3785653 | Myoclonic epilepsy of Lafora | 6.349484e-02 | 1.197 |
| R-HSA-6798695 | Neutrophil degranulation | 6.658633e-02 | 1.177 |
| R-HSA-164843 | 2-LTR circle formation | 7.460295e-02 | 1.127 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 7.460295e-02 | 1.127 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 8.010800e-02 | 1.096 |
| R-HSA-1433559 | Regulation of KIT signaling | 1.018060e-01 | 0.992 |
| R-HSA-9673770 | Signaling by PDGFRA extracellular domain mutants | 1.071509e-01 | 0.970 |
| R-HSA-9673767 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 1.071509e-01 | 0.970 |
| R-HSA-5656121 | Translesion synthesis by POLI | 1.124643e-01 | 0.949 |
| R-HSA-5655862 | Translesion synthesis by POLK | 1.177464e-01 | 0.929 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 1.282175e-01 | 0.892 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 9.367697e-02 | 1.028 |
| R-HSA-110312 | Translesion synthesis by REV1 | 1.071509e-01 | 0.970 |
| R-HSA-69109 | Leading Strand Synthesis | 9.102108e-02 | 1.041 |
| R-HSA-69091 | Polymerase switching | 9.102108e-02 | 1.041 |
| R-HSA-110320 | Translesion Synthesis by POLH | 1.334068e-01 | 0.875 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 1.048303e-01 | 0.980 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 1.177464e-01 | 0.929 |
| R-HSA-192814 | vRNA Synthesis | 8.010800e-02 | 1.096 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 8.558065e-02 | 1.068 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 1.282175e-01 | 0.892 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 1.281198e-01 | 0.892 |
| R-HSA-9927020 | Heme assimilation | 1.177464e-01 | 0.929 |
| R-HSA-3229121 | Glycogen storage diseases | 1.229974e-01 | 0.910 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 1.229974e-01 | 0.910 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 9.642947e-02 | 1.016 |
| R-HSA-9754706 | Atorvastatin ADME | 1.124643e-01 | 0.949 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 1.229974e-01 | 0.910 |
| R-HSA-416482 | G alpha (12/13) signalling events | 9.367697e-02 | 1.028 |
| R-HSA-9762293 | Regulation of CDH11 gene transcription | 6.906529e-02 | 1.161 |
| R-HSA-1237044 | Erythrocytes take up carbon dioxide and release oxygen | 1.334068e-01 | 0.875 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 1.334068e-01 | 0.875 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 1.029468e-01 | 0.987 |
| R-HSA-162592 | Integration of provirus | 8.558065e-02 | 1.068 |
| R-HSA-1480926 | O2/CO2 exchange in erythrocytes | 1.334068e-01 | 0.875 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 1.071509e-01 | 0.970 |
| R-HSA-9627069 | Regulation of the apoptosome activity | 7.460295e-02 | 1.127 |
| R-HSA-1247673 | Erythrocytes take up oxygen and release carbon dioxide | 9.102108e-02 | 1.041 |
| R-HSA-9659379 | Sensory processing of sound | 9.551061e-02 | 1.020 |
| R-HSA-9027307 | Biosynthesis of maresin-like SPMs | 1.177464e-01 | 0.929 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 7.595143e-02 | 1.119 |
| R-HSA-2028269 | Signaling by Hippo | 1.229974e-01 | 0.910 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 8.467054e-02 | 1.072 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 8.292544e-02 | 1.081 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 8.010800e-02 | 1.096 |
| R-HSA-9610379 | HCMV Late Events | 8.742582e-02 | 1.058 |
| R-HSA-73884 | Base Excision Repair | 1.182695e-01 | 0.927 |
| R-HSA-9762292 | Regulation of CDH11 function | 7.460295e-02 | 1.127 |
| R-HSA-111458 | Formation of apoptosome | 7.460295e-02 | 1.127 |
| R-HSA-111461 | Cytochrome c-mediated apoptotic response | 8.558065e-02 | 1.068 |
| R-HSA-8983711 | OAS antiviral response | 9.102108e-02 | 1.041 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 1.334068e-01 | 0.875 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 9.911648e-02 | 1.004 |
| R-HSA-111471 | Apoptotic factor-mediated response | 1.282175e-01 | 0.892 |
| R-HSA-109581 | Apoptosis | 9.319412e-02 | 1.031 |
| R-HSA-9006936 | Signaling by TGFB family members | 9.086804e-02 | 1.042 |
| R-HSA-2262752 | Cellular responses to stress | 9.084782e-02 | 1.042 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 7.109413e-02 | 1.148 |
| R-HSA-73857 | RNA Polymerase II Transcription | 8.362312e-02 | 1.078 |
| R-HSA-5619102 | SLC transporter disorders | 9.911648e-02 | 1.004 |
| R-HSA-212436 | Generic Transcription Pathway | 8.353597e-02 | 1.078 |
| R-HSA-9609690 | HCMV Early Events | 1.375965e-01 | 0.861 |
| R-HSA-3322077 | Glycogen synthesis | 1.385656e-01 | 0.858 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 1.385656e-01 | 0.858 |
| R-HSA-373753 | Nephrin family interactions | 1.385656e-01 | 0.858 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.385967e-01 | 0.858 |
| R-HSA-1500931 | Cell-Cell communication | 1.415210e-01 | 0.849 |
| R-HSA-69186 | Lagging Strand Synthesis | 1.436940e-01 | 0.843 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 1.436940e-01 | 0.843 |
| R-HSA-1640170 | Cell Cycle | 1.450396e-01 | 0.839 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 1.487921e-01 | 0.827 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 1.487921e-01 | 0.827 |
| R-HSA-112315 | Transmission across Chemical Synapses | 1.491426e-01 | 0.826 |
| R-HSA-5357801 | Programmed Cell Death | 1.514180e-01 | 0.820 |
| R-HSA-9669938 | Signaling by KIT in disease | 1.538602e-01 | 0.813 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 1.538602e-01 | 0.813 |
| R-HSA-5696398 | Nucleotide Excision Repair | 1.545539e-01 | 0.811 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.567669e-01 | 0.805 |
| R-HSA-69239 | Synthesis of DNA | 1.587115e-01 | 0.799 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 1.588985e-01 | 0.799 |
| R-HSA-9018682 | Biosynthesis of maresins | 1.588985e-01 | 0.799 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 1.639070e-01 | 0.785 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 1.639070e-01 | 0.785 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 1.639070e-01 | 0.785 |
| R-HSA-68882 | Mitotic Anaphase | 1.671117e-01 | 0.777 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 1.685620e-01 | 0.773 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 1.688861e-01 | 0.772 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 1.713061e-01 | 0.766 |
| R-HSA-525793 | Myogenesis | 1.738358e-01 | 0.760 |
| R-HSA-70635 | Urea cycle | 1.738358e-01 | 0.760 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 1.787714e-01 | 0.748 |
| R-HSA-9757110 | Prednisone ADME | 1.836478e-01 | 0.736 |
| R-HSA-5693538 | Homology Directed Repair | 1.862017e-01 | 0.730 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 1.862017e-01 | 0.730 |
| R-HSA-449147 | Signaling by Interleukins | 1.884846e-01 | 0.725 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 1.885105e-01 | 0.725 |
| R-HSA-68962 | Activation of the pre-replicative complex | 1.933446e-01 | 0.714 |
| R-HSA-388396 | GPCR downstream signalling | 1.963302e-01 | 0.707 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 1.969524e-01 | 0.706 |
| R-HSA-186763 | Downstream signal transduction | 1.981501e-01 | 0.703 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 1.981501e-01 | 0.703 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 1.981501e-01 | 0.703 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 1.981501e-01 | 0.703 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 1.981501e-01 | 0.703 |
| R-HSA-69190 | DNA strand elongation | 2.029273e-01 | 0.693 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 2.029273e-01 | 0.693 |
| R-HSA-4791275 | Signaling by WNT in cancer | 2.029273e-01 | 0.693 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 2.076763e-01 | 0.683 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 2.076763e-01 | 0.683 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 2.123973e-01 | 0.673 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 2.123973e-01 | 0.673 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 2.136212e-01 | 0.670 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 2.143065e-01 | 0.669 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 2.170905e-01 | 0.663 |
| R-HSA-9609646 | HCMV Infection | 2.182690e-01 | 0.661 |
| R-HSA-68886 | M Phase | 2.201999e-01 | 0.657 |
| R-HSA-9909396 | Circadian clock | 2.208533e-01 | 0.656 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 2.263940e-01 | 0.645 |
| R-HSA-74158 | RNA Polymerase III Transcription | 2.263940e-01 | 0.645 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 2.310047e-01 | 0.636 |
| R-HSA-4641257 | Degradation of AXIN | 2.310047e-01 | 0.636 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 2.310047e-01 | 0.636 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 2.310047e-01 | 0.636 |
| R-HSA-196757 | Metabolism of folate and pterines | 2.310047e-01 | 0.636 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 2.339955e-01 | 0.631 |
| R-HSA-9664407 | Parasite infection | 2.405856e-01 | 0.619 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 2.405856e-01 | 0.619 |
| R-HSA-9664417 | Leishmania phagocytosis | 2.405856e-01 | 0.619 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 2.427845e-01 | 0.615 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 2.446741e-01 | 0.611 |
| R-HSA-8982491 | Glycogen metabolism | 2.446741e-01 | 0.611 |
| R-HSA-9646399 | Aggrephagy | 2.446741e-01 | 0.611 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 2.491769e-01 | 0.603 |
| R-HSA-418594 | G alpha (i) signalling events | 2.521756e-01 | 0.598 |
| R-HSA-5674135 | MAP2K and MAPK activation | 2.536531e-01 | 0.596 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 2.536531e-01 | 0.596 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 2.581030e-01 | 0.588 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 2.581030e-01 | 0.588 |
| R-HSA-9679506 | SARS-CoV Infections | 2.601671e-01 | 0.585 |
| R-HSA-69242 | S Phase | 2.604029e-01 | 0.584 |
| R-HSA-1433557 | Signaling by SCF-KIT | 2.625266e-01 | 0.581 |
| R-HSA-446728 | Cell junction organization | 2.625428e-01 | 0.581 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 2.625428e-01 | 0.581 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 2.641481e-01 | 0.578 |
| R-HSA-5683826 | Surfactant metabolism | 2.669240e-01 | 0.574 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 2.669240e-01 | 0.574 |
| R-HSA-446652 | Interleukin-1 family signaling | 2.692214e-01 | 0.570 |
| R-HSA-372790 | Signaling by GPCR | 2.694592e-01 | 0.570 |
| R-HSA-69306 | DNA Replication | 2.714261e-01 | 0.566 |
| R-HSA-9612973 | Autophagy | 2.780393e-01 | 0.556 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 2.842560e-01 | 0.546 |
| R-HSA-9031628 | NGF-stimulated transcription | 2.842560e-01 | 0.546 |
| R-HSA-73893 | DNA Damage Bypass | 2.885252e-01 | 0.540 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 2.899838e-01 | 0.538 |
| R-HSA-9864848 | Complex IV assembly | 2.969882e-01 | 0.527 |
| R-HSA-68949 | Orc1 removal from chromatin | 3.011823e-01 | 0.521 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 3.011823e-01 | 0.521 |
| R-HSA-1221632 | Meiotic synapsis | 3.053516e-01 | 0.515 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 3.053516e-01 | 0.515 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 3.159031e-01 | 0.500 |
| R-HSA-5689880 | Ub-specific processing proteases | 3.175886e-01 | 0.498 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 3.177124e-01 | 0.498 |
| R-HSA-193648 | NRAGE signals death through JNK | 3.177124e-01 | 0.498 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 3.177124e-01 | 0.498 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 3.197746e-01 | 0.495 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 3.219590e-01 | 0.492 |
| R-HSA-6782135 | Dual incision in TC-NER | 3.258318e-01 | 0.487 |
| R-HSA-180786 | Extension of Telomeres | 3.298555e-01 | 0.482 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 3.298555e-01 | 0.482 |
| R-HSA-112316 | Neuronal System | 3.334715e-01 | 0.477 |
| R-HSA-379724 | tRNA Aminoacylation | 3.338555e-01 | 0.476 |
| R-HSA-186797 | Signaling by PDGF | 3.417847e-01 | 0.466 |
| R-HSA-9707616 | Heme signaling | 3.417847e-01 | 0.466 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 3.417847e-01 | 0.466 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 3.457142e-01 | 0.461 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 3.457142e-01 | 0.461 |
| R-HSA-5617833 | Cilium Assembly | 3.544970e-01 | 0.450 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 3.573640e-01 | 0.447 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 3.612015e-01 | 0.442 |
| R-HSA-196807 | Nicotinate metabolism | 3.612015e-01 | 0.442 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 3.650162e-01 | 0.438 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 3.673686e-01 | 0.435 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 3.725783e-01 | 0.429 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 3.763258e-01 | 0.424 |
| R-HSA-9638482 | Metal ion assimilation from the host | 3.763258e-01 | 0.424 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 3.763258e-01 | 0.424 |
| R-HSA-9824446 | Viral Infection Pathways | 3.771028e-01 | 0.424 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 3.800512e-01 | 0.420 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 3.800512e-01 | 0.420 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 3.837546e-01 | 0.416 |
| R-HSA-4086398 | Ca2+ pathway | 3.837546e-01 | 0.416 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 3.837546e-01 | 0.416 |
| R-HSA-5663084 | Diseases of carbohydrate metabolism | 3.837546e-01 | 0.416 |
| R-HSA-9749641 | Aspirin ADME | 3.837546e-01 | 0.416 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 3.837546e-01 | 0.416 |
| R-HSA-382551 | Transport of small molecules | 3.892539e-01 | 0.410 |
| R-HSA-380287 | Centrosome maturation | 3.910957e-01 | 0.408 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 3.910957e-01 | 0.408 |
| R-HSA-73894 | DNA Repair | 3.956077e-01 | 0.403 |
| R-HSA-9833482 | PKR-mediated signaling | 4.090722e-01 | 0.388 |
| R-HSA-9018677 | Biosynthesis of DHA-derived SPMs | 4.126040e-01 | 0.384 |
| R-HSA-168249 | Innate Immune System | 4.143913e-01 | 0.383 |
| R-HSA-418990 | Adherens junctions interactions | 4.157322e-01 | 0.381 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 4.230744e-01 | 0.374 |
| R-HSA-1500620 | Meiosis | 4.265233e-01 | 0.370 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 4.333601e-01 | 0.363 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 4.338591e-01 | 0.363 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 4.367482e-01 | 0.360 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 4.401162e-01 | 0.356 |
| R-HSA-9663891 | Selective autophagy | 4.401162e-01 | 0.356 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 4.402455e-01 | 0.356 |
| R-HSA-1236974 | ER-Phagosome pathway | 4.434643e-01 | 0.353 |
| R-HSA-5663205 | Infectious disease | 4.441118e-01 | 0.353 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 4.467926e-01 | 0.350 |
| R-HSA-391251 | Protein folding | 4.566597e-01 | 0.340 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 4.599099e-01 | 0.337 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 4.599099e-01 | 0.337 |
| R-HSA-157118 | Signaling by NOTCH | 4.602470e-01 | 0.337 |
| R-HSA-9837999 | Mitochondrial protein degradation | 4.631408e-01 | 0.334 |
| R-HSA-1474290 | Collagen formation | 4.631408e-01 | 0.334 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 4.663527e-01 | 0.331 |
| R-HSA-2168880 | Scavenging of heme from plasma | 4.695454e-01 | 0.328 |
| R-HSA-157579 | Telomere Maintenance | 4.758744e-01 | 0.323 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 4.790108e-01 | 0.320 |
| R-HSA-422356 | Regulation of insulin secretion | 4.790108e-01 | 0.320 |
| R-HSA-421270 | Cell-cell junction organization | 4.817709e-01 | 0.317 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 4.821287e-01 | 0.317 |
| R-HSA-5688426 | Deubiquitination | 4.894687e-01 | 0.310 |
| R-HSA-1483255 | PI Metabolism | 4.913718e-01 | 0.309 |
| R-HSA-9833110 | RSV-host interactions | 5.004517e-01 | 0.301 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 5.064157e-01 | 0.295 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 5.123091e-01 | 0.290 |
| R-HSA-9711123 | Cellular response to chemical stress | 5.139945e-01 | 0.289 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 5.152297e-01 | 0.288 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 5.255670e-01 | 0.279 |
| R-HSA-109582 | Hemostasis | 5.273148e-01 | 0.278 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 5.295749e-01 | 0.276 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 5.323932e-01 | 0.274 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 5.351947e-01 | 0.271 |
| R-HSA-9824443 | Parasitic Infection Pathways | 5.377452e-01 | 0.269 |
| R-HSA-9658195 | Leishmania infection | 5.377452e-01 | 0.269 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 5.379796e-01 | 0.269 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 5.395394e-01 | 0.268 |
| R-HSA-73886 | Chromosome Maintenance | 5.543456e-01 | 0.256 |
| R-HSA-69206 | G1/S Transition | 5.675447e-01 | 0.246 |
| R-HSA-194138 | Signaling by VEGF | 5.675447e-01 | 0.246 |
| R-HSA-195721 | Signaling by WNT | 5.675992e-01 | 0.246 |
| R-HSA-69481 | G2/M Checkpoints | 5.727154e-01 | 0.242 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 5.752777e-01 | 0.240 |
| R-HSA-8953854 | Metabolism of RNA | 5.826053e-01 | 0.235 |
| R-HSA-1474165 | Reproduction | 5.828739e-01 | 0.234 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 6.000793e-01 | 0.222 |
| R-HSA-163685 | Integration of energy metabolism | 6.000793e-01 | 0.222 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 6.041658e-01 | 0.219 |
| R-HSA-6807070 | PTEN Regulation | 6.072363e-01 | 0.217 |
| R-HSA-1632852 | Macroautophagy | 6.119371e-01 | 0.213 |
| R-HSA-9018678 | Biosynthesis of specialized proresolving mediators (SPMs) | 6.188840e-01 | 0.208 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 6.257079e-01 | 0.204 |
| R-HSA-166520 | Signaling by NTRKs | 6.301898e-01 | 0.201 |
| R-HSA-211859 | Biological oxidations | 6.334113e-01 | 0.198 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 6.346186e-01 | 0.197 |
| R-HSA-9679191 | Potential therapeutics for SARS | 6.346186e-01 | 0.197 |
| R-HSA-73887 | Death Receptor Signaling | 6.433194e-01 | 0.192 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 6.518151e-01 | 0.186 |
| R-HSA-422475 | Axon guidance | 6.600657e-01 | 0.180 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 6.702688e-01 | 0.174 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 6.780667e-01 | 0.169 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 6.838410e-01 | 0.165 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 6.838410e-01 | 0.165 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 6.876334e-01 | 0.163 |
| R-HSA-611105 | Respiratory electron transport | 6.932378e-01 | 0.159 |
| R-HSA-9675108 | Nervous system development | 7.017379e-01 | 0.154 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 7.023582e-01 | 0.153 |
| R-HSA-69275 | G2/M Transition | 7.077011e-01 | 0.150 |
| R-HSA-375276 | Peptide ligand-binding receptors | 7.077011e-01 | 0.150 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 7.112102e-01 | 0.148 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 7.112102e-01 | 0.148 |
| R-HSA-68877 | Mitotic Prometaphase | 7.198015e-01 | 0.143 |
| R-HSA-9640148 | Infection with Enterobacteria | 7.362326e-01 | 0.133 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 7.532070e-01 | 0.123 |
| R-HSA-9748784 | Drug ADME | 7.605608e-01 | 0.119 |
| R-HSA-72312 | rRNA processing | 7.800177e-01 | 0.108 |
| R-HSA-69620 | Cell Cycle Checkpoints | 8.120922e-01 | 0.090 |
| R-HSA-416476 | G alpha (q) signalling events | 8.188099e-01 | 0.087 |
| R-HSA-1483257 | Phospholipid metabolism | 8.499102e-01 | 0.071 |
| R-HSA-5653656 | Vesicle-mediated transport | 8.770781e-01 | 0.057 |
| R-HSA-1474244 | Extracellular matrix organization | 8.794477e-01 | 0.056 |
| R-HSA-597592 | Post-translational protein modification | 8.843641e-01 | 0.053 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 8.865775e-01 | 0.052 |
| R-HSA-1280218 | Adaptive Immune System | 8.866076e-01 | 0.052 |
| R-HSA-199991 | Membrane Trafficking | 9.121717e-01 | 0.040 |
| R-HSA-1266738 | Developmental Biology | 9.126085e-01 | 0.040 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.164273e-01 | 0.038 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.184478e-01 | 0.037 |
| R-HSA-392499 | Metabolism of proteins | 9.285225e-01 | 0.032 |
| R-HSA-5668914 | Diseases of metabolism | 9.333741e-01 | 0.030 |
| R-HSA-72766 | Translation | 9.341863e-01 | 0.030 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 9.472383e-01 | 0.024 |
| R-HSA-500792 | GPCR ligand binding | 9.754553e-01 | 0.011 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.794957e-01 | 0.009 |
| R-HSA-1430728 | Metabolism | 9.943191e-01 | 0.002 |
| R-HSA-9709957 | Sensory Perception | 9.962900e-01 | 0.002 |
| R-HSA-556833 | Metabolism of lipids | 9.991367e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
GAK |
0.745 | -0.024 | 1 | 0.673 |
BRAF |
0.743 | 0.036 | -4 | 0.724 |
EEF2K |
0.742 | 0.024 | 3 | 0.853 |
ALK4 |
0.742 | 0.073 | -2 | 0.800 |
VRK2 |
0.741 | -0.099 | 1 | 0.767 |
PKR |
0.739 | -0.045 | 1 | 0.693 |
MST2 |
0.738 | -0.001 | 1 | 0.722 |
TNIK |
0.738 | -0.012 | 3 | 0.871 |
MEK1 |
0.738 | -0.032 | 2 | 0.782 |
NIK |
0.738 | 0.045 | -3 | 0.815 |
LATS1 |
0.738 | 0.044 | -3 | 0.810 |
MST1 |
0.737 | -0.002 | 1 | 0.701 |
NEK1 |
0.737 | 0.008 | 1 | 0.668 |
ALK2 |
0.737 | 0.064 | -2 | 0.779 |
TGFBR1 |
0.737 | 0.094 | -2 | 0.792 |
BMPR1B |
0.737 | 0.116 | 1 | 0.720 |
BMPR2 |
0.737 | -0.020 | -2 | 0.810 |
TTK |
0.736 | 0.006 | -2 | 0.781 |
GCK |
0.735 | -0.038 | 1 | 0.697 |
MINK |
0.735 | -0.045 | 1 | 0.695 |
CAMK1B |
0.735 | 0.097 | -3 | 0.803 |
MARK2 |
0.734 | 0.438 | 4 | 0.614 |
OSR1 |
0.734 | -0.012 | 2 | 0.743 |
TAK1 |
0.734 | -0.074 | 1 | 0.683 |
TAO2 |
0.734 | -0.035 | 2 | 0.773 |
MEKK2 |
0.734 | -0.040 | 2 | 0.754 |
VRK1 |
0.734 | -0.087 | 2 | 0.752 |
NEK5 |
0.733 | -0.023 | 1 | 0.682 |
DAPK2 |
0.732 | -0.001 | -3 | 0.813 |
LRRK2 |
0.732 | -0.087 | 2 | 0.779 |
ASK1 |
0.732 | -0.056 | 1 | 0.697 |
MST3 |
0.732 | 0.008 | 2 | 0.764 |
ACVR2A |
0.732 | 0.079 | -2 | 0.793 |
MEKK1 |
0.731 | -0.016 | 1 | 0.729 |
ANKRD3 |
0.731 | 0.006 | 1 | 0.741 |
DLK |
0.731 | -0.062 | 1 | 0.751 |
PASK |
0.731 | 0.005 | -3 | 0.813 |
CAMLCK |
0.731 | 0.015 | -2 | 0.716 |
HGK |
0.731 | -0.032 | 3 | 0.854 |
MARK4 |
0.731 | 0.379 | 4 | 0.530 |
TAO3 |
0.731 | -0.043 | 1 | 0.700 |
MEK5 |
0.730 | -0.107 | 2 | 0.761 |
KHS1 |
0.730 | -0.026 | 1 | 0.688 |
MAP3K15 |
0.730 | -0.059 | 1 | 0.702 |
AMPKA1 |
0.730 | 0.264 | -3 | 0.797 |
MEKK6 |
0.730 | -0.043 | 1 | 0.710 |
ZAK |
0.729 | -0.008 | 1 | 0.737 |
MARK3 |
0.729 | 0.449 | 4 | 0.632 |
PDK1 |
0.729 | -0.059 | 1 | 0.667 |
MOS |
0.729 | -0.007 | 1 | 0.713 |
LKB1 |
0.728 | -0.040 | -3 | 0.788 |
JNK2 |
0.728 | 0.057 | 1 | 0.632 |
TSSK2 |
0.728 | 0.173 | -5 | 0.710 |
STLK3 |
0.728 | -0.034 | 1 | 0.699 |
CAMKK2 |
0.727 | -0.060 | -2 | 0.627 |
ACVR2B |
0.727 | 0.059 | -2 | 0.789 |
PRPK |
0.727 | -0.083 | -1 | 0.694 |
KHS2 |
0.727 | -0.022 | 1 | 0.692 |
BMPR1A |
0.727 | 0.091 | 1 | 0.701 |
NLK |
0.727 | 0.045 | 1 | 0.761 |
YSK1 |
0.727 | -0.028 | 2 | 0.751 |
CDKL1 |
0.727 | 0.037 | -3 | 0.769 |
HPK1 |
0.726 | -0.036 | 1 | 0.697 |
ICK |
0.726 | 0.041 | -3 | 0.791 |
DMPK1 |
0.726 | 0.068 | -3 | 0.715 |
NEK4 |
0.726 | -0.025 | 1 | 0.676 |
P38B |
0.726 | 0.067 | 1 | 0.659 |
MEK2 |
0.726 | -0.079 | 2 | 0.759 |
P38A |
0.725 | 0.060 | 1 | 0.686 |
BIKE |
0.725 | -0.025 | 1 | 0.558 |
TSSK1 |
0.724 | 0.211 | -3 | 0.809 |
ALPHAK3 |
0.724 | -0.072 | -1 | 0.687 |
DAPK3 |
0.724 | 0.018 | -3 | 0.756 |
PLK1 |
0.724 | 0.027 | -2 | 0.771 |
MEKK3 |
0.723 | -0.069 | 1 | 0.725 |
TLK1 |
0.723 | 0.052 | -2 | 0.790 |
MYO3A |
0.723 | -0.054 | 1 | 0.675 |
ATR |
0.723 | -0.018 | 1 | 0.708 |
JNK3 |
0.723 | 0.038 | 1 | 0.649 |
NEK8 |
0.723 | -0.057 | 2 | 0.741 |
MARK1 |
0.723 | 0.366 | 4 | 0.580 |
YSK4 |
0.723 | -0.056 | 1 | 0.686 |
CAMKK1 |
0.722 | -0.098 | -2 | 0.634 |
NEK11 |
0.722 | -0.111 | 1 | 0.706 |
SMMLCK |
0.722 | 0.004 | -3 | 0.770 |
RAF1 |
0.721 | 0.032 | 1 | 0.727 |
AMPKA2 |
0.721 | 0.235 | -3 | 0.774 |
NUAK2 |
0.720 | 0.147 | -3 | 0.796 |
MYO3B |
0.720 | -0.069 | 2 | 0.755 |
QSK |
0.720 | 0.338 | 4 | 0.566 |
ROCK2 |
0.720 | 0.042 | -3 | 0.751 |
PRP4 |
0.719 | 0.017 | -3 | 0.700 |
LOK |
0.718 | -0.017 | -2 | 0.657 |
SSTK |
0.718 | 0.263 | 4 | 0.498 |
PERK |
0.718 | -0.034 | -2 | 0.778 |
HRI |
0.718 | -0.010 | -2 | 0.800 |
MPSK1 |
0.717 | -0.036 | 1 | 0.607 |
P38G |
0.717 | 0.064 | 1 | 0.574 |
PBK |
0.717 | -0.035 | 1 | 0.596 |
CAMK2G |
0.717 | -0.023 | 2 | 0.789 |
CLK3 |
0.716 | 0.089 | 1 | 0.739 |
PLK3 |
0.716 | 0.047 | 2 | 0.736 |
PIM1 |
0.716 | 0.066 | -3 | 0.747 |
DSTYK |
0.716 | 0.061 | 2 | 0.830 |
COT |
0.716 | 0.049 | 2 | 0.804 |
CDK5 |
0.716 | 0.076 | 1 | 0.653 |
NEK9 |
0.715 | -0.020 | 2 | 0.783 |
AAK1 |
0.715 | -0.009 | 1 | 0.467 |
GRK6 |
0.715 | -0.024 | 1 | 0.741 |
TLK2 |
0.715 | -0.039 | 1 | 0.666 |
ERK5 |
0.715 | 0.026 | 1 | 0.758 |
GRK7 |
0.714 | 0.001 | 1 | 0.668 |
PKN3 |
0.713 | 0.013 | -3 | 0.782 |
CHK1 |
0.713 | 0.044 | -3 | 0.784 |
MLK2 |
0.713 | -0.093 | 2 | 0.763 |
CDKL5 |
0.713 | 0.062 | -3 | 0.760 |
CDK1 |
0.713 | 0.077 | 1 | 0.632 |
DCAMKL1 |
0.712 | 0.052 | -3 | 0.742 |
TAO1 |
0.712 | -0.053 | 1 | 0.653 |
GSK3B |
0.712 | -0.058 | 4 | 0.089 |
DAPK1 |
0.712 | 0.002 | -3 | 0.744 |
GSK3A |
0.712 | -0.034 | 4 | 0.089 |
HIPK1 |
0.712 | 0.056 | 1 | 0.701 |
MRCKA |
0.712 | 0.070 | -3 | 0.720 |
MLK1 |
0.711 | -0.054 | 2 | 0.741 |
CDK2 |
0.711 | 0.104 | 1 | 0.692 |
PDHK4 |
0.711 | -0.108 | 1 | 0.736 |
WNK1 |
0.711 | 0.045 | -2 | 0.721 |
ERK2 |
0.710 | 0.030 | 1 | 0.656 |
TGFBR2 |
0.710 | 0.062 | -2 | 0.781 |
NEK2 |
0.710 | -0.006 | 2 | 0.757 |
SKMLCK |
0.710 | -0.013 | -2 | 0.707 |
PDHK1 |
0.710 | -0.067 | 1 | 0.747 |
CAMK2B |
0.709 | 0.057 | 2 | 0.778 |
P70S6KB |
0.709 | 0.049 | -3 | 0.757 |
CHAK2 |
0.709 | -0.030 | -1 | 0.668 |
HUNK |
0.709 | 0.055 | 2 | 0.750 |
MAK |
0.708 | 0.054 | -2 | 0.607 |
ATM |
0.708 | 0.018 | 1 | 0.656 |
PIM3 |
0.708 | 0.026 | -3 | 0.795 |
DCAMKL2 |
0.708 | 0.038 | -3 | 0.758 |
CDC7 |
0.708 | 0.012 | 1 | 0.714 |
MST4 |
0.708 | 0.035 | 2 | 0.774 |
PIM2 |
0.707 | 0.053 | -3 | 0.716 |
CAMK2D |
0.707 | 0.022 | -3 | 0.782 |
MOK |
0.707 | 0.053 | 1 | 0.698 |
CLK4 |
0.707 | 0.059 | -3 | 0.733 |
WNK4 |
0.707 | -0.054 | -2 | 0.703 |
NEK3 |
0.707 | -0.050 | 1 | 0.677 |
PKCD |
0.707 | 0.009 | 2 | 0.714 |
ROCK1 |
0.707 | 0.036 | -3 | 0.717 |
NEK7 |
0.707 | 0.032 | -3 | 0.824 |
DNAPK |
0.707 | -0.011 | 1 | 0.611 |
SIK |
0.706 | 0.275 | -3 | 0.721 |
QIK |
0.706 | 0.214 | -3 | 0.784 |
MASTL |
0.706 | -0.135 | -2 | 0.707 |
ERK1 |
0.706 | 0.044 | 1 | 0.639 |
CRIK |
0.706 | 0.044 | -3 | 0.683 |
P38D |
0.706 | 0.044 | 1 | 0.577 |
MRCKB |
0.705 | 0.043 | -3 | 0.703 |
PKN2 |
0.704 | 0.018 | -3 | 0.784 |
MLK4 |
0.704 | -0.054 | 2 | 0.663 |
CAMK2A |
0.704 | 0.052 | 2 | 0.787 |
GRK5 |
0.703 | -0.120 | -3 | 0.779 |
JNK1 |
0.703 | 0.024 | 1 | 0.610 |
PINK1 |
0.703 | -0.067 | 1 | 0.669 |
CDK3 |
0.703 | 0.098 | 1 | 0.579 |
TBK1 |
0.703 | 0.002 | 1 | 0.663 |
DRAK1 |
0.703 | -0.017 | 1 | 0.667 |
CAMK1D |
0.703 | 0.080 | -3 | 0.663 |
MELK |
0.702 | 0.118 | -3 | 0.757 |
CLK1 |
0.702 | 0.088 | -3 | 0.707 |
SLK |
0.702 | -0.076 | -2 | 0.607 |
IRAK4 |
0.702 | -0.056 | 1 | 0.657 |
GRK2 |
0.702 | -0.015 | -2 | 0.617 |
DYRK2 |
0.702 | 0.036 | 1 | 0.698 |
NEK6 |
0.702 | 0.016 | -2 | 0.780 |
ULK2 |
0.702 | -0.015 | 2 | 0.725 |
PLK2 |
0.701 | 0.015 | -3 | 0.760 |
BUB1 |
0.701 | -0.000 | -5 | 0.687 |
CAMK1G |
0.701 | 0.113 | -3 | 0.723 |
SGK3 |
0.701 | 0.030 | -3 | 0.736 |
CDK16 |
0.701 | 0.071 | 1 | 0.570 |
DYRK1A |
0.700 | 0.041 | 1 | 0.693 |
MLK3 |
0.700 | -0.063 | 2 | 0.682 |
HIPK3 |
0.699 | 0.025 | 1 | 0.697 |
RSK2 |
0.699 | 0.050 | -3 | 0.739 |
HIPK4 |
0.699 | 0.078 | 1 | 0.706 |
CDK6 |
0.699 | 0.042 | 1 | 0.609 |
CHAK1 |
0.699 | -0.042 | 2 | 0.715 |
MYLK4 |
0.698 | 0.029 | -2 | 0.631 |
NDR1 |
0.698 | 0.071 | -3 | 0.789 |
ERK7 |
0.698 | 0.010 | 2 | 0.501 |
SRPK3 |
0.698 | 0.037 | -3 | 0.702 |
AKT2 |
0.697 | 0.033 | -3 | 0.670 |
HASPIN |
0.697 | -0.049 | -1 | 0.486 |
GRK1 |
0.697 | -0.028 | -2 | 0.657 |
NUAK1 |
0.697 | 0.150 | -3 | 0.753 |
MTOR |
0.697 | -0.107 | 1 | 0.707 |
IKKE |
0.697 | -0.020 | 1 | 0.667 |
RIPK3 |
0.696 | -0.063 | 3 | 0.717 |
SRPK1 |
0.696 | 0.052 | -3 | 0.721 |
WNK3 |
0.696 | -0.032 | 1 | 0.678 |
P90RSK |
0.696 | 0.037 | -3 | 0.745 |
RIPK1 |
0.696 | -0.142 | 1 | 0.681 |
CDK14 |
0.696 | 0.031 | 1 | 0.631 |
CDK4 |
0.695 | 0.024 | 1 | 0.605 |
SGK1 |
0.695 | 0.036 | -3 | 0.607 |
IRE2 |
0.694 | -0.016 | 2 | 0.659 |
PRKD3 |
0.694 | 0.053 | -3 | 0.705 |
NIM1 |
0.694 | 0.092 | 3 | 0.783 |
DYRK1B |
0.694 | 0.045 | 1 | 0.644 |
CDK8 |
0.694 | 0.042 | 1 | 0.669 |
PKCH |
0.694 | -0.016 | 2 | 0.654 |
MAPKAPK3 |
0.693 | 0.041 | -3 | 0.736 |
CDK7 |
0.692 | 0.043 | 1 | 0.652 |
TTBK2 |
0.692 | -0.065 | 2 | 0.708 |
CDK17 |
0.692 | 0.041 | 1 | 0.567 |
RSK4 |
0.692 | 0.050 | -3 | 0.724 |
PKCB |
0.691 | 0.004 | 2 | 0.675 |
CAMK1A |
0.691 | 0.095 | -3 | 0.625 |
BRSK1 |
0.691 | 0.181 | -3 | 0.751 |
CHK2 |
0.691 | 0.018 | -3 | 0.614 |
DYRK3 |
0.691 | 0.024 | 1 | 0.709 |
CAMK4 |
0.691 | -0.015 | -3 | 0.766 |
IRE1 |
0.691 | -0.062 | 1 | 0.639 |
BRSK2 |
0.690 | 0.191 | -3 | 0.760 |
SMG1 |
0.690 | -0.063 | 1 | 0.659 |
GRK4 |
0.690 | -0.051 | -2 | 0.721 |
RSK3 |
0.690 | 0.043 | -3 | 0.738 |
PAK2 |
0.690 | -0.030 | -2 | 0.622 |
IRAK1 |
0.690 | -0.092 | -1 | 0.568 |
PAK1 |
0.690 | -0.019 | -2 | 0.640 |
CLK2 |
0.689 | 0.069 | -3 | 0.720 |
PRKD1 |
0.689 | 0.032 | -3 | 0.766 |
PKCA |
0.689 | -0.037 | 2 | 0.657 |
LATS2 |
0.688 | 0.021 | -5 | 0.623 |
CDK18 |
0.688 | 0.034 | 1 | 0.597 |
HIPK2 |
0.688 | 0.048 | 1 | 0.617 |
AKT1 |
0.687 | 0.020 | -3 | 0.686 |
ULK1 |
0.687 | -0.037 | -3 | 0.761 |
GCN2 |
0.687 | -0.015 | 2 | 0.764 |
DYRK4 |
0.686 | 0.034 | 1 | 0.641 |
MSK1 |
0.686 | 0.002 | -3 | 0.722 |
CDK10 |
0.686 | 0.053 | 1 | 0.616 |
NDR2 |
0.685 | 0.044 | -3 | 0.795 |
PKG2 |
0.685 | 0.027 | -2 | 0.532 |
PKCZ |
0.685 | -0.064 | 2 | 0.718 |
PKACG |
0.685 | 0.013 | -2 | 0.591 |
PKCE |
0.685 | 0.001 | 2 | 0.651 |
CDK9 |
0.685 | 0.020 | 1 | 0.642 |
IKKB |
0.684 | -0.090 | -2 | 0.644 |
RIPK2 |
0.684 | -0.100 | 1 | 0.688 |
PAK3 |
0.684 | -0.030 | -2 | 0.647 |
AURB |
0.684 | 0.003 | -2 | 0.518 |
AURA |
0.684 | -0.006 | -2 | 0.505 |
CDK13 |
0.684 | 0.007 | 1 | 0.631 |
PHKG1 |
0.684 | 0.029 | -3 | 0.771 |
BCKDK |
0.683 | -0.071 | -1 | 0.647 |
PKCG |
0.683 | -0.033 | 2 | 0.671 |
SBK |
0.683 | 0.030 | -3 | 0.560 |
STK33 |
0.682 | -0.061 | 2 | 0.586 |
PLK4 |
0.682 | -0.052 | 2 | 0.570 |
CDK12 |
0.682 | 0.009 | 1 | 0.619 |
CK2A2 |
0.682 | 0.048 | 1 | 0.593 |
PRKD2 |
0.682 | 0.041 | -3 | 0.725 |
SRPK2 |
0.681 | 0.061 | -3 | 0.659 |
MNK2 |
0.681 | -0.001 | -2 | 0.649 |
MAPKAPK2 |
0.681 | 0.047 | -3 | 0.699 |
PKCI |
0.681 | -0.022 | 2 | 0.676 |
IKKA |
0.681 | -0.068 | -2 | 0.646 |
CDK19 |
0.680 | 0.038 | 1 | 0.642 |
P70S6K |
0.680 | 0.023 | -3 | 0.688 |
PKCT |
0.680 | -0.028 | 2 | 0.664 |
MSK2 |
0.680 | -0.009 | -3 | 0.716 |
MNK1 |
0.679 | -0.012 | -2 | 0.657 |
PKACB |
0.679 | 0.028 | -2 | 0.538 |
GRK3 |
0.678 | -0.026 | -2 | 0.570 |
AURC |
0.676 | 0.021 | -2 | 0.520 |
PAK6 |
0.675 | 0.057 | -2 | 0.570 |
CK2A1 |
0.674 | 0.026 | 1 | 0.581 |
SNRK |
0.674 | 0.020 | 2 | 0.608 |
AKT3 |
0.673 | 0.035 | -3 | 0.617 |
MAPKAPK5 |
0.673 | -0.001 | -3 | 0.702 |
PHKG2 |
0.671 | 0.034 | -3 | 0.738 |
TTBK1 |
0.671 | -0.060 | 2 | 0.618 |
PKACA |
0.671 | 0.024 | -2 | 0.497 |
FAM20C |
0.669 | 0.024 | 2 | 0.589 |
PKN1 |
0.669 | -0.000 | -3 | 0.695 |
CK1D |
0.669 | -0.029 | -3 | 0.449 |
KIS |
0.668 | 0.059 | 1 | 0.686 |
CK1A2 |
0.667 | -0.016 | -3 | 0.453 |
EPHA6 |
0.662 | 0.094 | -1 | 0.776 |
CK1E |
0.662 | -0.025 | -3 | 0.503 |
PDHK3_TYR |
0.661 | 0.055 | 4 | 0.289 |
YANK3 |
0.661 | -0.053 | 2 | 0.405 |
PRKX |
0.660 | 0.034 | -3 | 0.669 |
PAK5 |
0.657 | 0.011 | -2 | 0.506 |
BMPR2_TYR |
0.656 | 0.016 | -1 | 0.763 |
EPHB4 |
0.654 | 0.051 | -1 | 0.751 |
TESK1_TYR |
0.654 | -0.006 | 3 | 0.872 |
MAP2K4_TYR |
0.653 | -0.058 | -1 | 0.738 |
YANK2 |
0.653 | -0.064 | 2 | 0.422 |
MAP2K6_TYR |
0.653 | -0.045 | -1 | 0.749 |
PDHK4_TYR |
0.651 | -0.025 | 2 | 0.803 |
TNNI3K_TYR |
0.651 | 0.110 | 1 | 0.778 |
PDHK1_TYR |
0.651 | -0.026 | -1 | 0.767 |
MAP2K7_TYR |
0.650 | -0.054 | 2 | 0.792 |
RET |
0.650 | -0.001 | 1 | 0.712 |
PAK4 |
0.650 | 0.019 | -2 | 0.522 |
PKMYT1_TYR |
0.649 | -0.060 | 3 | 0.829 |
DDR1 |
0.649 | 0.005 | 4 | 0.281 |
EPHB1 |
0.649 | 0.048 | 1 | 0.786 |
TXK |
0.647 | 0.038 | 1 | 0.743 |
LIMK2_TYR |
0.647 | -0.006 | -3 | 0.817 |
PINK1_TYR |
0.647 | -0.096 | 1 | 0.704 |
ROS1 |
0.646 | -0.002 | 3 | 0.778 |
JAK3 |
0.646 | 0.028 | 1 | 0.697 |
EPHA4 |
0.646 | 0.013 | 2 | 0.718 |
PKG1 |
0.646 | 0.011 | -2 | 0.458 |
MST1R |
0.645 | -0.027 | 3 | 0.782 |
EPHB2 |
0.645 | 0.045 | -1 | 0.740 |
INSRR |
0.645 | 0.019 | 3 | 0.752 |
TYK2 |
0.645 | -0.047 | 1 | 0.710 |
JAK2 |
0.645 | -0.031 | 1 | 0.726 |
EPHB3 |
0.644 | 0.021 | -1 | 0.733 |
FGFR2 |
0.642 | 0.001 | 3 | 0.777 |
TYRO3 |
0.642 | -0.046 | 3 | 0.793 |
ITK |
0.642 | -0.002 | -1 | 0.641 |
ABL2 |
0.641 | -0.019 | -1 | 0.652 |
FER |
0.640 | -0.049 | 1 | 0.747 |
LIMK1_TYR |
0.640 | -0.071 | 2 | 0.781 |
CSF1R |
0.640 | -0.054 | 3 | 0.759 |
FGR |
0.639 | -0.034 | 1 | 0.721 |
FGFR1 |
0.638 | 0.015 | 3 | 0.744 |
KDR |
0.638 | 0.003 | 3 | 0.728 |
DDR2 |
0.638 | 0.031 | 3 | 0.724 |
EPHA7 |
0.638 | -0.001 | 2 | 0.716 |
PDGFRB |
0.638 | -0.024 | 3 | 0.779 |
BLK |
0.637 | 0.013 | -1 | 0.691 |
FLT1 |
0.637 | 0.019 | -1 | 0.793 |
YES1 |
0.637 | -0.047 | -1 | 0.656 |
TEK |
0.637 | -0.004 | 3 | 0.733 |
ABL1 |
0.637 | -0.023 | -1 | 0.635 |
BMX |
0.636 | -0.012 | -1 | 0.571 |
CK1G1 |
0.636 | -0.038 | -3 | 0.493 |
LCK |
0.636 | -0.033 | -1 | 0.679 |
HCK |
0.635 | -0.053 | -1 | 0.674 |
TEC |
0.635 | -0.023 | -1 | 0.568 |
MET |
0.635 | -0.034 | 3 | 0.748 |
SRMS |
0.635 | -0.066 | 1 | 0.759 |
PTK2 |
0.633 | 0.047 | -1 | 0.771 |
EPHA3 |
0.633 | -0.021 | 2 | 0.694 |
FLT3 |
0.633 | -0.058 | 3 | 0.768 |
JAK1 |
0.633 | -0.031 | 1 | 0.688 |
KIT |
0.633 | -0.066 | 3 | 0.755 |
ALK |
0.632 | -0.034 | 3 | 0.718 |
INSR |
0.632 | -0.016 | 3 | 0.723 |
FGFR3 |
0.632 | -0.015 | 3 | 0.750 |
EPHA5 |
0.630 | -0.008 | 2 | 0.701 |
ERBB2 |
0.629 | -0.057 | 1 | 0.682 |
NEK10_TYR |
0.629 | -0.067 | 1 | 0.558 |
PDGFRA |
0.629 | -0.078 | 3 | 0.784 |
FRK |
0.629 | -0.042 | -1 | 0.701 |
LTK |
0.628 | -0.048 | 3 | 0.731 |
FLT4 |
0.628 | -0.025 | 3 | 0.725 |
EPHA8 |
0.628 | -0.025 | -1 | 0.718 |
EPHA1 |
0.627 | -0.057 | 3 | 0.724 |
FYN |
0.627 | -0.036 | -1 | 0.657 |
EGFR |
0.627 | -0.019 | 1 | 0.628 |
MERTK |
0.626 | -0.073 | 3 | 0.747 |
NTRK1 |
0.626 | -0.088 | -1 | 0.696 |
BTK |
0.626 | -0.099 | -1 | 0.581 |
SYK |
0.626 | 0.009 | -1 | 0.751 |
TNK1 |
0.625 | -0.073 | 3 | 0.769 |
AXL |
0.625 | -0.090 | 3 | 0.742 |
NTRK2 |
0.625 | -0.057 | 3 | 0.718 |
PTK2B |
0.624 | -0.029 | -1 | 0.588 |
NTRK3 |
0.623 | -0.069 | -1 | 0.656 |
EPHA2 |
0.623 | -0.010 | -1 | 0.726 |
TNK2 |
0.622 | -0.103 | 3 | 0.695 |
LYN |
0.622 | -0.064 | 3 | 0.680 |
PTK6 |
0.622 | -0.124 | -1 | 0.563 |
CK1G3 |
0.621 | -0.063 | -3 | 0.325 |
IGF1R |
0.620 | -0.036 | 3 | 0.674 |
MATK |
0.619 | -0.062 | -1 | 0.588 |
FGFR4 |
0.619 | -0.047 | -1 | 0.684 |
WEE1_TYR |
0.618 | -0.099 | -1 | 0.579 |
CSK |
0.617 | -0.083 | 2 | 0.726 |
ERBB4 |
0.617 | -0.020 | 1 | 0.655 |
CK1G2 |
0.615 | -0.045 | -3 | 0.414 |
SRC |
0.614 | -0.081 | -1 | 0.639 |
MUSK |
0.607 | -0.073 | 1 | 0.591 |
CK1A |
0.606 | -0.043 | -3 | 0.366 |
FES |
0.596 | -0.095 | -1 | 0.542 |
ZAP70 |
0.594 | -0.055 | -1 | 0.632 |