Motif 857 (n=95)
Position-wise Probabilities
Download
| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0J9YVX5 | None | S170 | ochoa | Golgi-associated PDZ and coiled-coil motif-containing protein (CFTR-associated ligand) (PDZ protein interacting specifically with TC10) | None |
| A4D1E1 | ZNF804B | S877 | ochoa | Zinc finger protein 804B | None |
| A8MV72 | None | S204 | ochoa | Putative UPF0607 protein ENSP00000382826 | None |
| D6RIA3 | C4orf54 | S1035 | ochoa | Uncharacterized protein C4orf54 (Familial obliterative portal venopathy) | None |
| O00560 | SDCBP | S131 | ochoa|psp | Syntenin-1 (Melanoma differentiation-associated protein 9) (MDA-9) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18) (Scaffold protein Pbp1) (Syndecan-binding protein 1) | Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527). Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292). In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed:22660413). Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120). In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PubMed:11498591). May also play a role in vesicular trafficking (PubMed:11179419). Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (PubMed:10230395). {ECO:0000269|PubMed:10230395, ECO:0000269|PubMed:11179419, ECO:0000269|PubMed:11498591, ECO:0000269|PubMed:22660413, ECO:0000269|PubMed:25893292, ECO:0000269|PubMed:26539120, ECO:0000303|PubMed:26291527}. |
| O43683 | BUB1 | S525 | ochoa|psp | Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) | Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (PubMed:35044816). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:17158872, ECO:0000269|PubMed:19487456, ECO:0000269|PubMed:20739936, ECO:0000269|PubMed:35044816}. |
| O75569 | PRKRA | S246 | psp | Interferon-inducible double-stranded RNA-dependent protein kinase activator A (PKR-associated protein X) (PKR-associating protein X) (Protein activator of the interferon-induced protein kinase) (Protein kinase, interferon-inducible double-stranded RNA-dependent activator) | Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity). {ECO:0000250, ECO:0000269|PubMed:10336432, ECO:0000269|PubMed:11238927, ECO:0000269|PubMed:16424907, ECO:0000269|PubMed:16982605, ECO:0000269|PubMed:17452327, ECO:0000269|PubMed:9687506}. |
| O95071 | UBR5 | S191 | psp | E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250|UniProtKB:Q80TP3, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:28689657, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:33208877, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37478862}. |
| O95171 | SCEL | S312 | ochoa | Sciellin | May function in the assembly or regulation of proteins in the cornified envelope. The LIM domain may be involved in homotypic or heterotypic associations and may function to localize sciellin to the cornified envelope. |
| O95235 | KIF20A | S757 | ochoa | Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6) | Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:12939256}. |
| O95239 | KIF4A | S1139 | ochoa | Chromosome-associated kinesin KIF4A (Chromokinesin-A) | Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis (PubMed:29848660). Translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis (PubMed:15297875, PubMed:15625105). May play a role in mitotic chromosomal positioning and bipolar spindle stabilization (By similarity). {ECO:0000250|UniProtKB:P33174, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:29848660}. |
| O95425 | SVIL | S938 | ochoa | Supervillin (Archvillin) (p205/p250) | [Isoform 1]: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699). Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (PubMed:19109420). {ECO:0000269|PubMed:12711699, ECO:0000269|PubMed:19109420}.; FUNCTION: [Isoform 2]: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity). {ECO:0000250|UniProtKB:O46385}. |
| O96028 | NSD2 | S30 | ochoa | Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein) | Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:19808676, PubMed:22099308, PubMed:27571355, PubMed:29728617, PubMed:33941880). Also monomethylates nucleosomal histone H3 at 'Lys-36' (H3K36me) in vitro (PubMed:22099308). Does not trimethylate nucleosomal histone H3 at 'Lys-36' (H3K36me3) (PubMed:22099308). However, specifically trimethylates histone H3 at 'Lys-36' (H3K36me3) at euchromatic regions in embryonic stem (ES) cells (By similarity). By methylating histone H3 at 'Lys-36', involved in the regulation of gene transcription during various biological processes (PubMed:16115125, PubMed:22099308, PubMed:29728617). In ES cells, associates with developmental transcription factors such as SALL1 and represses inappropriate gene transcription mediated by histone deacetylation (By similarity). During heart development, associates with transcription factor NKX2-5 to repress transcription of NKX2-5 target genes (By similarity). Plays an essential role in adipogenesis, by regulating expression of genes involved in pre-adipocyte differentiation (PubMed:29728617). During T-cell receptor (TCR) and CD28-mediated T-cell activation, promotes the transcription of transcription factor BCL6 which is required for follicular helper T (Tfh) cell differentiation (By similarity). During B-cell development, required for the generation of the B1 lineage (By similarity). During B2 cell activation, may contribute to the control of isotype class switch recombination (CRS), splenic germinal center formation, and the humoral immune response (By similarity). Plays a role in class switch recombination of the immunoglobulin heavy chain (IgH) locus during B-cell activation (By similarity). By regulating the methylation of histone H3 at 'Lys-36' and histone H4 at 'Lys-20' at the IgH locus, involved in TP53BP1 recruitment to the IgH switch region and promotes the transcription of IgA (By similarity). {ECO:0000250|UniProtKB:Q8BVE8, ECO:0000269|PubMed:16115125, ECO:0000269|PubMed:19808676, ECO:0000269|PubMed:22099308, ECO:0000269|PubMed:27571355, ECO:0000269|PubMed:29728617, ECO:0000269|PubMed:33941880}.; FUNCTION: [Isoform 1]: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2). {ECO:0000269|PubMed:22099308}.; FUNCTION: [Isoform 4]: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:22099308). Methylation of histone H3 at 'Lys-27' is controversial (PubMed:18172012, PubMed:22099308). Mono-, di- or tri-methylates histone H3 at 'Lys-27' (H3K27me, H3K27me2 and H3K27me3) (PubMed:18172012). Does not methylate histone H3 at 'Lys-27' (PubMed:22099308). May act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment (PubMed:11152655, PubMed:18172012). {ECO:0000269|PubMed:11152655, ECO:0000269|PubMed:18172012, ECO:0000269|PubMed:22099308}. |
| P04049 | RAF1 | S471 | psp | RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) | Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}. |
| P04626 | ERBB2 | S819 | ochoa | Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340) | Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. {ECO:0000305}.; FUNCTION: In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. {ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:15380516, ECO:0000269|PubMed:21555369}. |
| P05198 | EIF2S1 | S49 | ochoa|psp | Eukaryotic translation initiation factor 2 subunit 1 (Eukaryotic translation initiation factor 2 subunit alpha) (eIF-2-alpha) (eIF-2A) (eIF-2alpha) (eIF2-alpha) | Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:16289705, PubMed:38340717). This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex (43S PIC) (PubMed:16289705). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex (PubMed:16289705). In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B (PubMed:16289705). EIF2S1/eIF2-alpha is a key component of the integrated stress response (ISR), required for adaptation to various stress: phosphorylation by metabolic-stress sensing protein kinases (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2) in response to stress converts EIF2S1/eIF2-alpha in a global protein synthesis inhibitor, leading to an attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming (PubMed:19131336, PubMed:33384352, PubMed:38340717). EIF2S1/eIF2-alpha also acts as an activator of mitophagy in response to mitochondrial damage: phosphorylation by EIF2AK1/HRI promotes relocalization to the mitochondrial surface, thereby triggering PRKN-independent mitophagy (PubMed:38340717). {ECO:0000269|PubMed:16289705, ECO:0000269|PubMed:19131336, ECO:0000269|PubMed:33384352, ECO:0000269|PubMed:38340717}. |
| P05546 | SERPIND1 | S37 | ochoa | Heparin cofactor 2 (Heparin cofactor II) (HC-II) (Protease inhibitor leuserpin-2) (HLS2) (Serpin D1) | Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner. {ECO:0000269|PubMed:1939083, ECO:0000269|PubMed:32827448}.; FUNCTION: Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils. {ECO:0000269|PubMed:1939083}.; FUNCTION: [Isoform 2]: Shows negligible inhibition, in vitro, of thrombin and tPA and no inhibition of factor Xa, in vitro. {ECO:0000269|PubMed:32827448}. |
| P06493 | CDK1 | T222 | ochoa | Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase) | Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition via association with multiple interphase cyclins (PubMed:16407259, PubMed:16933150, PubMed:17459720, PubMed:18356527, PubMed:19509060, PubMed:19917720, PubMed:20171170, PubMed:20935635, PubMed:20937773, PubMed:21063390, PubMed:2188730, PubMed:23355470, PubMed:2344612, PubMed:23601106, PubMed:23602554, PubMed:25556658, PubMed:26829474, PubMed:27814491, PubMed:30139873, PubMed:30704899). Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, GOLGA2/GM130, GRASP1, UBE2A/hHR6A, HIST1H1 proteins/histone H1, HMGA1, HIVEP3/KRC, KAT5, LMNA, LMNB, LBR, MKI67, LATS1, MAP1B, MAP4, MARCKS, MCM2, MCM4, MKLP1, MLST8, MYB, NEFH, NFIC, NPC/nuclear pore complex, PITPNM1/NIR2, NPM1, NCL, NUCKS1, NPM1/numatrin, ORC1, PRKAR2A, EEF1E1/p18, EIF3F/p47, p53/TP53, NONO/p54NRB, PAPOLA, PLEC/plectin, RB1, TPPP, UL40/R2, RAB4A, RAP1GAP, RBBP8/CtIP, RCC1, RPS6KB1/S6K1, KHDRBS1/SAM68, ESPL1, SKI, BIRC5/survivin, STIP1, TEX14, beta-tubulins, MAPT/TAU, NEDD1, VIM/vimentin, TK1, FOXO1, RUNX1/AML1, SAMHD1, SIRT2, CGAS and RUNX2 (PubMed:16407259, PubMed:16933150, PubMed:17459720, PubMed:18356527, PubMed:19202191, PubMed:19509060, PubMed:19917720, PubMed:20171170, PubMed:20935635, PubMed:20937773, PubMed:21063390, PubMed:2188730, PubMed:23355470, PubMed:2344612, PubMed:23601106, PubMed:23602554, PubMed:25012651, PubMed:25556658, PubMed:26829474, PubMed:27814491, PubMed:30704899, PubMed:32351706, PubMed:34741373). CDK1/CDC2-cyclin-B controls pronuclear union in interphase fertilized eggs (PubMed:18480403, PubMed:20360007). Essential for early stages of embryonic development (PubMed:18480403, PubMed:20360007). During G2 and early mitosis, CDC25A/B/C-mediated dephosphorylation activates CDK1/cyclin complexes which phosphorylate several substrates that trigger at least centrosome separation, Golgi dynamics, nuclear envelope breakdown and chromosome condensation (PubMed:18480403, PubMed:20360007, PubMed:2188730, PubMed:2344612, PubMed:30139873). Once chromosomes are condensed and aligned at the metaphase plate, CDK1 activity is switched off by WEE1- and PKMYT1-mediated phosphorylation to allow sister chromatid separation, chromosome decondensation, reformation of the nuclear envelope and cytokinesis (PubMed:18480403, PubMed:20360007). Phosphorylates KRT5 during prometaphase and metaphase (By similarity). Inactivated by PKR/EIF2AK2- and WEE1-mediated phosphorylation upon DNA damage to stop cell cycle and genome replication at the G2 checkpoint thus facilitating DNA repair (PubMed:20360007). Reactivated after successful DNA repair through WIP1-dependent signaling leading to CDC25A/B/C-mediated dephosphorylation and restoring cell cycle progression (PubMed:20395957). Catalyzes lamin (LMNA, LMNB1 and LMNB2) phosphorylation at the onset of mitosis, promoting nuclear envelope breakdown (PubMed:2188730, PubMed:2344612, PubMed:37788673). In proliferating cells, CDK1-mediated FOXO1 phosphorylation at the G2-M phase represses FOXO1 interaction with 14-3-3 proteins and thereby promotes FOXO1 nuclear accumulation and transcription factor activity, leading to cell death of postmitotic neurons (PubMed:18356527). The phosphorylation of beta-tubulins regulates microtubule dynamics during mitosis (PubMed:16371510). NEDD1 phosphorylation promotes PLK1-mediated NEDD1 phosphorylation and subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation (PubMed:19509060). In addition, CC2D1A phosphorylation regulates CC2D1A spindle pole localization and association with SCC1/RAD21 and centriole cohesion during mitosis (PubMed:20171170). The phosphorylation of Bcl-xL/BCL2L1 after prolongated G2 arrest upon DNA damage triggers apoptosis (PubMed:19917720). In contrast, CASP8 phosphorylation during mitosis prevents its activation by proteolysis and subsequent apoptosis (PubMed:20937773). This phosphorylation occurs in cancer cell lines, as well as in primary breast tissues and lymphocytes (PubMed:20937773). EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing (PubMed:20935635). CALD1 phosphorylation promotes Schwann cell migration during peripheral nerve regeneration (By similarity). CDK1-cyclin-B complex phosphorylates NCKAP5L and mediates its dissociation from centrosomes during mitosis (PubMed:26549230). Regulates the amplitude of the cyclic expression of the core clock gene BMAL1 by phosphorylating its transcriptional repressor NR1D1, and this phosphorylation is necessary for SCF(FBXW7)-mediated ubiquitination and proteasomal degradation of NR1D1 (PubMed:27238018). Phosphorylates EML3 at 'Thr-881' which is essential for its interaction with HAUS augmin-like complex and TUBG1 (PubMed:30723163). Phosphorylates CGAS during mitosis, leading to its inhibition, thereby preventing CGAS activation by self DNA during mitosis (PubMed:32351706). Phosphorylates SKA3 on multiple sites during mitosis which promotes SKA3 binding to the NDC80 complex and anchoring of the SKA complex to kinetochores, to enable stable attachment of mitotic spindle microtubules to kinetochores (PubMed:28479321, PubMed:31804178, PubMed:32491969). {ECO:0000250|UniProtKB:P11440, ECO:0000250|UniProtKB:P39951, ECO:0000269|PubMed:16371510, ECO:0000269|PubMed:16407259, ECO:0000269|PubMed:16933150, ECO:0000269|PubMed:17459720, ECO:0000269|PubMed:18356527, ECO:0000269|PubMed:18480403, ECO:0000269|PubMed:19202191, ECO:0000269|PubMed:19509060, ECO:0000269|PubMed:19917720, ECO:0000269|PubMed:20171170, ECO:0000269|PubMed:20360007, ECO:0000269|PubMed:20395957, ECO:0000269|PubMed:20935635, ECO:0000269|PubMed:20937773, ECO:0000269|PubMed:21063390, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:23355470, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23601106, ECO:0000269|PubMed:23602554, ECO:0000269|PubMed:25012651, ECO:0000269|PubMed:25556658, ECO:0000269|PubMed:26549230, ECO:0000269|PubMed:26829474, ECO:0000269|PubMed:27238018, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:28479321, ECO:0000269|PubMed:30139873, ECO:0000269|PubMed:30704899, ECO:0000269|PubMed:30723163, ECO:0000269|PubMed:31804178, ECO:0000269|PubMed:32351706, ECO:0000269|PubMed:32491969, ECO:0000269|PubMed:34741373, ECO:0000269|PubMed:37788673}.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. {ECO:0000269|PubMed:21516087}. |
| P10398 | ARAF | S432 | psp | Serine/threonine-protein kinase A-Raf (EC 2.7.11.1) (Proto-oncogene A-Raf) (Proto-oncogene A-Raf-1) (Proto-oncogene Pks) | Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade. Phosphorylates PFKFB2 (PubMed:36402789). {ECO:0000269|PubMed:22609986, ECO:0000269|PubMed:36402789}.; FUNCTION: [Isoform 2]: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation. {ECO:0000269|PubMed:22609986}. |
| P14618 | PKM | S205 | ochoa | Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (Tyrosine-protein kinase PKM2) (EC 2.7.10.2) (p58) | Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723, PubMed:20847263). The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production (PubMed:15996096, PubMed:1854723, PubMed:20847263). The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival (PubMed:15996096, PubMed:1854723, PubMed:20847263). {ECO:0000269|PubMed:15996096, ECO:0000269|PubMed:1854723, ECO:0000269|PubMed:20847263}.; FUNCTION: [Isoform M2]: Isoform specifically expressed during embryogenesis that has low pyruvate kinase activity by itself and requires allosteric activation by D-fructose 1,6-bisphosphate (FBP) for pyruvate kinase activity (PubMed:18337823, PubMed:20847263). In addition to its pyruvate kinase activity in the cytoplasm, also acts as a regulator of transcription in the nucleus by acting as a protein kinase (PubMed:18191611, PubMed:21620138, PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661). Translocates into the nucleus in response to various signals, such as EGF receptor activation, and homodimerizes, leading to its conversion into a protein threonine- and tyrosine-protein kinase (PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661, PubMed:26787900). Catalyzes phosphorylation of STAT3 at 'Tyr-705' and histone H3 at 'Thr-11' (H3T11ph), leading to activate transcription (PubMed:22306293, PubMed:22901803, PubMed:24120661). Its ability to activate transcription plays a role in cancer cells by promoting cell proliferation and promote tumorigenesis (PubMed:18337823, PubMed:22901803, PubMed:26787900). Promotes the expression of the immune checkpoint protein CD274 in BMAL1-deficient macrophages (By similarity). May also act as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum-destined mRNAs (By similarity). Plays a role in caspase independent cell death of tumor cells (PubMed:17308100). {ECO:0000250|UniProtKB:P52480, ECO:0000269|PubMed:17308100, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263, ECO:0000269|PubMed:21620138, ECO:0000269|PubMed:22056988, ECO:0000269|PubMed:22306293, ECO:0000269|PubMed:22901803, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:26787900}.; FUNCTION: [Isoform M1]: Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth (PubMed:18337823). In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity (PubMed:20847263). {ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263}. |
| P15056 | BRAF | S579 | psp | Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) | Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). Phosphorylates PFKFB2 (PubMed:36402789). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179). {ECO:0000269|PubMed:1508179, ECO:0000269|PubMed:21441910, ECO:0000269|PubMed:29433126, ECO:0000269|PubMed:36402789, ECO:0000305}. |
| P23921 | RRM1 | S133 | ochoa | Ribonucleoside-diphosphate reductase large subunit (EC 1.17.4.1) (Ribonucleoside-diphosphate reductase subunit M1) (Ribonucleotide reductase large subunit) | Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. |
| P27361 | MAPK3 | S263 | ochoa | Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (Microtubule-associated protein 2 kinase) (p44-ERK1) | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway (PubMed:34497368). MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade also plays a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, DEPTOR, FRS2 or GRB10) (PubMed:35216969). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. {ECO:0000269|PubMed:10393181, ECO:0000269|PubMed:10617468, ECO:0000269|PubMed:12110590, ECO:0000269|PubMed:12356731, ECO:0000269|PubMed:12974390, ECO:0000269|PubMed:15788397, ECO:0000269|PubMed:15952796, ECO:0000269|PubMed:16581800, ECO:0000269|PubMed:19265199, ECO:0000269|PubMed:34497368, ECO:0000269|PubMed:35216969, ECO:0000269|PubMed:8325880, ECO:0000269|PubMed:9155018, ECO:0000269|PubMed:9480836}. |
| P28482 | MAPK1 | S246 | ochoa|psp | Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade also plays a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1 and FXR1) and a variety of other signaling-related molecules (like ARHGEF2, DCC, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. Mediates phosphorylation of TPR in response to EGF stimulation. May play a role in the spindle assembly checkpoint. Phosphorylates PML and promotes its interaction with PIN1, leading to PML degradation. Phosphorylates CDK2AP2 (By similarity). Phosphorylates phosphoglycerate kinase PGK1 under hypoxic conditions to promote its targeting to the mitochondrion and suppress the formation of acetyl-coenzyme A from pyruvate (PubMed:26942675). {ECO:0000250|UniProtKB:P63086, ECO:0000269|PubMed:10617468, ECO:0000269|PubMed:10637505, ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:12110590, ECO:0000269|PubMed:12356731, ECO:0000269|PubMed:12792650, ECO:0000269|PubMed:12794087, ECO:0000269|PubMed:12974390, ECO:0000269|PubMed:15184391, ECO:0000269|PubMed:15241487, ECO:0000269|PubMed:15616583, ECO:0000269|PubMed:15664191, ECO:0000269|PubMed:15788397, ECO:0000269|PubMed:15952796, ECO:0000269|PubMed:16581800, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:19265199, ECO:0000269|PubMed:19879846, ECO:0000269|PubMed:22033920, ECO:0000269|PubMed:26942675, ECO:0000269|PubMed:32721402, ECO:0000269|PubMed:7588608, ECO:0000269|PubMed:8622688, ECO:0000269|PubMed:9480836, ECO:0000269|PubMed:9596579, ECO:0000269|PubMed:9649500, ECO:0000269|PubMed:9687510, ECO:0000303|PubMed:15526160, ECO:0000303|PubMed:16393692, ECO:0000303|PubMed:19565474, ECO:0000303|PubMed:21779493}.; FUNCTION: Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity. {ECO:0000269|PubMed:19879846}. |
| P35367 | HRH1 | S233 | ochoa | Histamine H1 receptor (H1-R) (H1R) (HH1R) | G-protein-coupled receptor for histamine, a biogenic amine that functions as an immune modulator and a neurotransmitter (PubMed:33828102, PubMed:8280179). Through the H1 receptor, histamine mediates the contraction of smooth muscles and increases capillary permeability due to contraction of terminal venules. Also mediates neurotransmission in the central nervous system and thereby regulates circadian rhythms, emotional and locomotor activities as well as cognitive functions (By similarity). {ECO:0000250|UniProtKB:P70174, ECO:0000269|PubMed:33828102, ECO:0000269|PubMed:8280179}. |
| P39748 | FEN1 | S352 | ochoa | Flap endonuclease 1 (FEN-1) (EC 3.1.-.-) (DNase IV) (Flap structure-specific endonuclease 1) (Maturation factor 1) (MF1) (hFEN-1) | Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA. {ECO:0000255|HAMAP-Rule:MF_03140, ECO:0000269|PubMed:10744741, ECO:0000269|PubMed:11986308, ECO:0000269|PubMed:18443037, ECO:0000269|PubMed:20729856, ECO:0000269|PubMed:26751069, ECO:0000269|PubMed:7961795, ECO:0000269|PubMed:8621570}. |
| P46531 | NOTCH1 | S2148 | ochoa | Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)] | Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). {ECO:0000269|PubMed:20616313}. |
| P46781 | RPS9 | S163 | ochoa | Small ribosomal subunit protein uS4 (40S ribosomal protein S9) | Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| P48549 | KCNJ3 | S401 | psp | G protein-activated inward rectifier potassium channel 1 (GIRK-1) (Inward rectifier K(+) channel Kir3.1) (Potassium channel, inwardly rectifying subfamily J member 3) | Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This potassium channel is controlled by G proteins (PubMed:8804710, PubMed:8868049). This receptor plays a crucial role in regulating the heartbeat (By similarity). {ECO:0000250|UniProtKB:P63251, ECO:0000269|PubMed:8804710, ECO:0000269|PubMed:8868049}. |
| P49023 | PXN | S414 | ochoa | Paxillin | Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion. {ECO:0000269|PubMed:25015296}. |
| P54886 | ALDH18A1 | S79 | ochoa | Delta-1-pyrroline-5-carboxylate synthase (P5CS) (Aldehyde dehydrogenase family 18 member A1) [Includes: Glutamate 5-kinase (GK) (EC 2.7.2.11) (Gamma-glutamyl kinase); Gamma-glutamyl phosphate reductase (GPR) (EC 1.2.1.41) (Glutamate-5-semialdehyde dehydrogenase) (Glutamyl-gamma-semialdehyde dehydrogenase)] | Bifunctional enzyme that converts glutamate to glutamate 5-semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine. {ECO:0000269|PubMed:10037775, ECO:0000269|PubMed:11092761, ECO:0000269|PubMed:26297558, ECO:0000269|PubMed:26320891, ECO:0000269|PubMed:39506109}. |
| P60709 | ACTB | Y198 | ochoa | Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] | Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (PubMed:39321809, PubMed:38609661). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:Q6QAQ1, ECO:0000269|PubMed:25255767, ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| P61160 | ACTR2 | Y202 | psp | Actin-related protein 2 (Actin-like protein 2) | ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9000076). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9000076). Seems to contact the pointed end of the daughter actin filament (PubMed:9000076). In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation (PubMed:29058690). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:17220302, PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). {ECO:0000269|PubMed:17220302, ECO:0000269|PubMed:29058690, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:9000076}. |
| P62736 | ACTA2 | Y200 | ochoa | Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P63261 | ACTG1 | Y198 | ochoa|psp | Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage (By similarity). {ECO:0000250|UniProtKB:P63260, ECO:0000305|PubMed:29581253}. |
| P63267 | ACTG2 | Y199 | ochoa | Actin, gamma-enteric smooth muscle (EC 3.6.4.-) (Alpha-actin-3) (Gamma-2-actin) (Smooth muscle gamma-actin) [Cleaved into: Actin, gamma-enteric smooth muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P68032 | ACTC1 | Y200 | ochoa | Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P68133 | ACTA1 | Y200 | ochoa | Actin, alpha skeletal muscle (EC 3.6.4.-) (Alpha-actin-1) [Cleaved into: Actin, alpha skeletal muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P68402 | PAFAH1B2 | S64 | ochoa | Platelet-activating factor acetylhydrolase IB subunit alpha2 (EC 3.1.1.47) (PAF acetylhydrolase 30 kDa subunit) (PAF-AH 30 kDa subunit) (PAF-AH subunit beta) (PAFAH subunit beta) | Alpha2 catalytic subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF. The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition. The alpha2/alpha2 homodimer (PAFAH1B2/PAFAH1B2 homodimer) hydrolyzes PAF and 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylethanolamine (AAGPE) more efficiently than 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid (AAGPA). In contrast, the alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B3 heterodimer) hydrolyzes AAGPA more efficiently than PAF, but has little hydrolytic activity towards AAGPE (By similarity). May play a role in male germ cell meiosis during the late pachytenestage and meiotic divisions as well as early spermiogenesis (By similarity). {ECO:0000250|UniProtKB:P68401, ECO:0000250|UniProtKB:Q61206}. |
| Q00536 | CDK16 | T380 | psp | Cyclin-dependent kinase 16 (EC 2.7.11.22) (Cell division protein kinase 16) (PCTAIRE-motif protein kinase 1) (Serine/threonine-protein kinase PCTAIRE-1) | Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro). {ECO:0000250, ECO:0000269|PubMed:22184064, ECO:0000269|PubMed:22796189, ECO:0000269|PubMed:22798068}. |
| Q00537 | CDK17 | S83 | ochoa | Cyclin-dependent kinase 17 (EC 2.7.11.22) (Cell division protein kinase 17) (PCTAIRE-motif protein kinase 2) (Serine/threonine-protein kinase PCTAIRE-2) | May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1 (By similarity). {ECO:0000250}. |
| Q14202 | ZMYM3 | S464 | ochoa | Zinc finger MYM-type protein 3 (Zinc finger protein 261) | Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}. |
| Q14993 | COL19A1 | S81 | ochoa | Collagen alpha-1(XIX) chain (Collagen alpha-1(Y) chain) | May act as a cross-bridge between fibrils and other extracellular matrix molecules. Involved in skeletal myogenesis in the developing esophagus. May play a role in organization of the pericellular matrix or the sphinteric smooth muscle. {ECO:0000269|PubMed:12788917}. |
| Q15759 | MAPK11 | T241 | psp | Mitogen-activated protein kinase 11 (MAP kinase 11) (MAPK 11) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (Stress-activated protein kinase 2b) (SAPK2b) (p38-2) | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway (PubMed:12452429, PubMed:20626350, PubMed:35857590). MAPK11 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors (PubMed:12452429, PubMed:20626350, PubMed:35857590). Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each (PubMed:12452429, PubMed:20626350, PubMed:35857590). MAPK11 functions are mostly redundant with those of MAPK14 (PubMed:12452429, PubMed:20626350, PubMed:35857590). Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets (PubMed:12452429, PubMed:20626350). RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1 (PubMed:9687510). RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery. On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2 (PubMed:11154262). In the cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17. Such phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR signaling and cell proliferation. Additional examples of p38 MAPK substrates are the FGFR1. FGFR1 can be translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A (PubMed:10330143, PubMed:15356147, PubMed:9430721). The p38 MAPKs are emerging as important modulators of gene expression by regulating chromatin modifiers and remodelers (PubMed:10330143, PubMed:15356147, PubMed:9430721). The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on 'Ser-10' (H3S10ph) in LPS-stimulated myeloid cells. This phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for increased NF-kappa-B recruitment. Phosphorylates NLRP1 downstream of MAP3K20/ZAK in response to UV-B irradiation and ribosome collisions, promoting activation of the NLRP1 inflammasome and pyroptosis (PubMed:35857590). Phosphorylates methyltransferase DOT1L on 'Ser-834', 'Thr-900', 'Ser-902', 'Thr-984', 'Ser-1001', 'Ser-1009' and 'Ser-1104' (PubMed:38270553). {ECO:0000269|PubMed:10330143, ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:15356147, ECO:0000269|PubMed:35857590, ECO:0000269|PubMed:38270553, ECO:0000269|PubMed:9430721, ECO:0000269|PubMed:9687510, ECO:0000303|PubMed:12452429, ECO:0000303|PubMed:20626350}. |
| Q5H9R7 | PPP6R3 | S315 | ochoa | Serine/threonine-protein phosphatase 6 regulatory subunit 3 (SAPS domain family member 3) (Sporulation-induced transcript 4-associated protein SAPL) | Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. May have an important role in maintaining immune self-tolerance. {ECO:0000269|PubMed:11401438, ECO:0000269|PubMed:16769727}. |
| Q5SRE5 | NUP188 | S1257 | ochoa | Nucleoporin NUP188 (hNup188) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope (Probable). Required for proper protein transport into the nucleus (PubMed:32275884). {ECO:0000269|PubMed:32275884, ECO:0000305|PubMed:32275884}. |
| Q5SY16 | NOL9 | S241 | ochoa | Polynucleotide 5'-hydroxyl-kinase NOL9 (EC 2.7.1.78) (Nucleolar protein 9) | Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of single-stranded and double-stranded RNA and DNA substrates (PubMed:21063389). Involved in rRNA processing and its kinase activity is required for the processing of the 32S precursor into 5.8S and 28S rRNAs, more specifically for the generation of the major 5.8S(S) form (PubMed:21063389). Required for the efficient pre-rRNA processing of internal transcribed spacer 2 (ITS2) (PubMed:21063389). Associates with LAS1L to form an ITS2 pre-rRNA endonuclease-kinase complex and is responsible for the transport of this complex into the nucleolus (PubMed:31288032). {ECO:0000269|PubMed:21063389, ECO:0000269|PubMed:31288032}. |
| Q5TCZ1 | SH3PXD2A | S662 | ochoa | SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains) | Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells (PubMed:27789576). Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. {ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:15710328, ECO:0000269|PubMed:15710903, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497, ECO:0000269|PubMed:27789576}. |
| Q5VWN6 | TASOR2 | S19 | ochoa | Protein TASOR 2 | None |
| Q6KC79 | NIPBL | S1243 | ochoa | Nipped-B-like protein (Delangin) (SCC2 homolog) | Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}. |
| Q6PJ61 | FBXO46 | S313 | ochoa | F-box only protein 46 (F-box only protein 34-like) | Substrate-recognition component of the SCF(FBXO46) protein ligase complex, which mediates the ubiquitination and degradation of target proteins (PubMed:30171069). In absence of stress, the SCF(FBXO46) complex catalyzes ubiquitination and degradation of MTOR-phosphorylated FBXO31 (PubMed:30171069). {ECO:0000269|PubMed:30171069}. |
| Q6VY07 | PACS1 | S320 | ochoa | Phosphofurin acidic cluster sorting protein 1 (PACS-1) | Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN. Required for normal ER Ca2+ handling in lymphocytes. Together with WDR37, it plays an essential role in lymphocyte development, quiescence and survival. Required for stabilizing peripheral lymphocyte populations (By similarity). {ECO:0000250|UniProtKB:Q8K212, ECO:0000269|PubMed:11331585, ECO:0000269|PubMed:15692563}. |
| Q7L8C5 | SYT13 | S58 | ochoa | Synaptotagmin-13 (Synaptotagmin XIII) (SytXIII) | May be involved in transport vesicle docking to the plasma membrane. {ECO:0000250}. |
| Q7L9B9 | EEPD1 | S428 | ochoa | Endonuclease/exonuclease/phosphatase family domain-containing protein 1 | None |
| Q86TV6 | TTC7B | S196 | ochoa | Tetratricopeptide repeat protein 7B (TPR repeat protein 7B) (Tetratricopeptide repeat protein 7-like-1) (TPR repeat protein 7-like-1) | Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, plays a central role in bridging PI4KA to EFR3B and HYCC1, via direct interactions (PubMed:26571211). {ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:26571211}. |
| Q86V87 | FHIP2B | S325 | psp | FHF complex subunit HOOK-interacting protein 2B (FHIP2B) (Retinoic acid-induced protein 16) | Able to activate MAPK/ERK and TGFB signaling pathways (PubMed:22971576). May regulate the activity of genes involved in intestinal barrier function and immunoprotective inflammation (By similarity). May play a role in cell proliferation (PubMed:22971576). {ECO:0000250|UniProtKB:Q80YR2, ECO:0000269|PubMed:22971576}. |
| Q8IWP9 | CCDC28A | S255 | ochoa | Coiled-coil domain-containing protein 28A (CCRL1AP) | None |
| Q8IXJ6 | SIRT2 | S53 | ochoa | NAD-dependent protein deacetylase sirtuin-2 (EC 2.3.1.286) (NAD-dependent protein defatty-acylase sirtuin-2) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 2) (SIR2-like protein 2) | NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors (PubMed:12620231, PubMed:16648462, PubMed:18249187, PubMed:18332217, PubMed:18995842, PubMed:20543840, PubMed:20587414, PubMed:21081649, PubMed:21726808, PubMed:21949390, PubMed:22014574, PubMed:22771473, PubMed:23468428, PubMed:23908241, PubMed:24177535, PubMed:24681946, PubMed:24769394, PubMed:24940000). Participates in the modulation of multiple and diverse biological processes such as cell cycle control, genomic integrity, microtubule dynamics, cell differentiation, metabolic networks, and autophagy (PubMed:12620231, PubMed:16648462, PubMed:18249187, PubMed:18332217, PubMed:18995842, PubMed:20543840, PubMed:20587414, PubMed:21081649, PubMed:21726808, PubMed:21949390, PubMed:22014574, PubMed:22771473, PubMed:23468428, PubMed:23908241, PubMed:24177535, PubMed:24681946, PubMed:24769394, PubMed:24940000). Plays a major role in the control of cell cycle progression and genomic stability (PubMed:12697818, PubMed:16909107, PubMed:17488717, PubMed:17726514, PubMed:19282667, PubMed:23468428). Functions in the antephase checkpoint preventing precocious mitotic entry in response to microtubule stress agents, and hence allowing proper inheritance of chromosomes (PubMed:12697818, PubMed:16909107, PubMed:17488717, PubMed:17726514, PubMed:19282667, PubMed:23468428). Positively regulates the anaphase promoting complex/cyclosome (APC/C) ubiquitin ligase complex activity by deacetylating CDC20 and FZR1, then allowing progression through mitosis (PubMed:22014574). Associates both with chromatin at transcriptional start sites (TSSs) and enhancers of active genes (PubMed:23468428). Plays a role in cell cycle and chromatin compaction through epigenetic modulation of the regulation of histone H4 'Lys-20' methylation (H4K20me1) during early mitosis (PubMed:23468428). Specifically deacetylates histone H4 at 'Lys-16' (H4K16ac) between the G2/M transition and metaphase enabling H4K20me1 deposition by KMT5A leading to ulterior levels of H4K20me2 and H4K20me3 deposition throughout cell cycle, and mitotic S-phase progression (PubMed:23468428). Deacetylates KMT5A modulating KMT5A chromatin localization during the mitotic stress response (PubMed:23468428). Also deacetylates histone H3 at 'Lys-57' (H3K56ac) during the mitotic G2/M transition (PubMed:20587414). Upon bacterium Listeria monocytogenes infection, deacetylates 'Lys-18' of histone H3 in a receptor tyrosine kinase MET- and PI3K/Akt-dependent manner, thereby inhibiting transcriptional activity and promoting late stages of listeria infection (PubMed:23908241). During oocyte meiosis progression, may deacetylate histone H4 at 'Lys-16' (H4K16ac) and alpha-tubulin, regulating spindle assembly and chromosome alignment by influencing microtubule dynamics and kinetochore function (PubMed:24940000). Deacetylates histone H4 at 'Lys-16' (H4K16ac) at the VEGFA promoter and thereby contributes to regulate expression of VEGFA, a key regulator of angiogenesis (PubMed:24940000). Deacetylates alpha-tubulin at 'Lys-40' and hence controls neuronal motility, oligodendroglial cell arbor projection processes and proliferation of non-neuronal cells (PubMed:18332217, PubMed:18995842). Phosphorylation at Ser-368 by a G1/S-specific cyclin E-CDK2 complex inactivates SIRT2-mediated alpha-tubulin deacetylation, negatively regulating cell adhesion, cell migration and neurite outgrowth during neuronal differentiation (PubMed:17488717). Deacetylates PARD3 and participates in the regulation of Schwann cell peripheral myelination formation during early postnatal development and during postinjury remyelination (PubMed:21949390). Involved in several cellular metabolic pathways (PubMed:20543840, PubMed:21726808, PubMed:24769394). Plays a role in the regulation of blood glucose homeostasis by deacetylating and stabilizing phosphoenolpyruvate carboxykinase PCK1 activity in response to low nutrient availability (PubMed:21726808). Acts as a key regulator in the pentose phosphate pathway (PPP) by deacetylating and activating the glucose-6-phosphate G6PD enzyme, and therefore, stimulates the production of cytosolic NADPH to counteract oxidative damage (PubMed:24769394). Maintains energy homeostasis in response to nutrient deprivation as well as energy expenditure by inhibiting adipogenesis and promoting lipolysis (PubMed:20543840). Attenuates adipocyte differentiation by deacetylating and promoting FOXO1 interaction to PPARG and subsequent repression of PPARG-dependent transcriptional activity (PubMed:20543840). Plays a role in the regulation of lysosome-mediated degradation of protein aggregates by autophagy in neuronal cells (PubMed:20543840). Deacetylates FOXO1 in response to oxidative stress or serum deprivation, thereby negatively regulating FOXO1-mediated autophagy (PubMed:20543840). Deacetylates a broad range of transcription factors and co-regulators regulating target gene expression. Deacetylates transcriptional factor FOXO3 stimulating the ubiquitin ligase SCF(SKP2)-mediated FOXO3 ubiquitination and degradation (By similarity). Deacetylates HIF1A and therefore promotes HIF1A degradation and inhibition of HIF1A transcriptional activity in tumor cells in response to hypoxia (PubMed:24681946). Deacetylates RELA in the cytoplasm inhibiting NF-kappaB-dependent transcription activation upon TNF-alpha stimulation (PubMed:21081649). Inhibits transcriptional activation by deacetylating p53/TP53 and EP300 (PubMed:18249187, PubMed:18995842). Also deacetylates EIF5A (PubMed:22771473). Functions as a negative regulator on oxidative stress-tolerance in response to anoxia-reoxygenation conditions (PubMed:24769394). Plays a role as tumor suppressor (PubMed:22014574). In addition to protein deacetylase activity, also has activity toward long-chain fatty acyl groups and mediates protein-lysine demyristoylation and depalmitoylation of target proteins, such as ARF6 and KRAS, thereby regulating their association with membranes (PubMed:25704306, PubMed:29239724, PubMed:32103017). {ECO:0000250|UniProtKB:Q8VDQ8, ECO:0000269|PubMed:12620231, ECO:0000269|PubMed:12697818, ECO:0000269|PubMed:16648462, ECO:0000269|PubMed:16909107, ECO:0000269|PubMed:17488717, ECO:0000269|PubMed:17574768, ECO:0000269|PubMed:17726514, ECO:0000269|PubMed:18249187, ECO:0000269|PubMed:18332217, ECO:0000269|PubMed:18640115, ECO:0000269|PubMed:18722353, ECO:0000269|PubMed:18995842, ECO:0000269|PubMed:19282667, ECO:0000269|PubMed:20543840, ECO:0000269|PubMed:20587414, ECO:0000269|PubMed:21081649, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:21949390, ECO:0000269|PubMed:22014574, ECO:0000269|PubMed:22771473, ECO:0000269|PubMed:22819792, ECO:0000269|PubMed:23468428, ECO:0000269|PubMed:23908241, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:24177535, ECO:0000269|PubMed:24681946, ECO:0000269|PubMed:24769394, ECO:0000269|PubMed:24940000, ECO:0000269|PubMed:25704306, ECO:0000269|PubMed:29239724, ECO:0000269|PubMed:32103017}.; FUNCTION: [Isoform 1]: Deacetylates EP300, alpha-tubulin and histone H3 and H4. {ECO:0000269|PubMed:24177535}.; FUNCTION: [Isoform 2]: Deacetylates EP300, alpha-tubulin and histone H3 and H4. {ECO:0000269|PubMed:24177535}.; FUNCTION: [Isoform 5]: Lacks deacetylation activity, at least toward known SIRT2 targets. {ECO:0000269|PubMed:24177535}. |
| Q8IYI6 | EXOC8 | S372 | ochoa | Exocyst complex component 8 (Exocyst complex 84 kDa subunit) | Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. |
| Q8TDJ6 | DMXL2 | S1137 | ochoa | DmX-like protein 2 (Rabconnectin-3) | May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles (PubMed:11809763). Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity). {ECO:0000250|UniProtKB:Q8BPN8, ECO:0000269|PubMed:11809763}. |
| Q8TEB1 | DCAF11 | S147 | ochoa | DDB1- and CUL4-associated factor 11 (WD repeat-containing protein 23) | May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240}. |
| Q92574 | TSC1 | S468 | ochoa|psp | Hamartin (Tuberous sclerosis 1 protein) | Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12906785, PubMed:15340059, PubMed:24529379, PubMed:28215400). The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12906785, PubMed:15340059, PubMed:24529379). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12271141, PubMed:24529379, PubMed:28215400, PubMed:33215753). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Within the TSC-TBC complex, TSC1 stabilizes TSC2 and prevents TSC2 self-aggregation (PubMed:10585443, PubMed:28215400). Acts as a tumor suppressor (PubMed:9242607). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 (PubMed:29127155). Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity (PubMed:29127155). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155). Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1 (PubMed:16464865, PubMed:29127155). {ECO:0000250|UniProtKB:Q9Z136, ECO:0000269|PubMed:10585443, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:16464865, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:29127155, ECO:0000269|PubMed:33215753, ECO:0000269|PubMed:9242607}. |
| Q92900 | UPF1 | S600 | ochoa | Regulator of nonsense transcripts 1 (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent helicase RENT1) (Nonsense mRNA reducing factor 1) (NORF1) (Up-frameshift suppressor 1 homolog) (hUpf1) | RNA-dependent helicase required for nonsense-mediated decay (NMD) of aberrant mRNAs containing premature stop codons and modulates the expression level of normal mRNAs (PubMed:11163187, PubMed:16086026, PubMed:18172165, PubMed:21145460, PubMed:21419344, PubMed:24726324). Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD (PubMed:11544179, PubMed:25220460). Recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex (PubMed:19417104). In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) (located 50-55 or more nucleotides downstream from the termination codon) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD (PubMed:21419344). Phosphorylated UPF1 is recognized by EST1B/SMG5, SMG6 and SMG7 which are thought to provide a link to the mRNA degradation machinery involving exonucleolytic and endonucleolytic pathways, and to serve as adapters to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation and allowing the recycling of NMD factors (PubMed:12554878). UPF1 can also activate NMD without UPF2 or UPF3, and in the absence of the NMD-enhancing downstream EJC indicative for alternative NMD pathways (PubMed:18447585). Plays a role in replication-dependent histone mRNA degradation at the end of phase S; the function is independent of UPF2 (PubMed:16086026, PubMed:18172165). For the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed (PubMed:18447585, PubMed:25220460). The ATPase activity of UPF1 is required for disassembly of mRNPs undergoing NMD (PubMed:21145460). Together with UPF2 and dependent on TDRD6, mediates the degradation of mRNA harboring long 3'UTR by inducing the NMD machinery (By similarity). Also capable of unwinding double-stranded DNA and translocating on single-stranded DNA (PubMed:30218034). {ECO:0000250|UniProtKB:Q9EPU0, ECO:0000269|PubMed:11163187, ECO:0000269|PubMed:11544179, ECO:0000269|PubMed:12554878, ECO:0000269|PubMed:16086026, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:18447585, ECO:0000269|PubMed:19417104, ECO:0000269|PubMed:21145460, ECO:0000269|PubMed:21419344, ECO:0000269|PubMed:24726324, ECO:0000269|PubMed:25220460, ECO:0000269|PubMed:30218034}. |
| Q96E17 | RAB3C | S196 | ochoa | Ras-related protein Rab-3C (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. {ECO:0000250|UniProtKB:P10949}. |
| Q96HC4 | PDLIM5 | S76 | ochoa | PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein) | May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May be required to restrain postsynaptic growth of excitatory synapses. Isoform 1, but not isoform 2, expression favors spine thinning and elongation. {ECO:0000250|UniProtKB:Q62920}. |
| Q99959 | PKP2 | S34 | ochoa | Plakophilin-2 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:25208567). Regulates focal adhesion turnover resulting in changes in focal adhesion size, cell adhesion and cell spreading, potentially via transcriptional modulation of beta-integrins (PubMed:23884246). Required to maintain gingival epithelial barrier function (PubMed:34368962). Important component of the desmosome that is also required for localization of desmosome component proteins such as DSC2, DSG2 and JUP to the desmosome cell-cell junction (PubMed:22781308, PubMed:25208567). Required for the formation of desmosome cell junctions in cardiomyocytes, thereby required for the correct formation of the heart, specifically trabeculation and formation of the atria walls (By similarity). Loss of desmosome cell junctions leads to mis-localization of DSP and DSG2 resulting in disruption of cell-cell adhesion and disordered intermediate filaments (By similarity). Modulates profibrotic gene expression in cardiomyocytes via regulation of DSP expression and subsequent activation of downstream TGFB1 and MAPK14/p38 MAPK signaling (By similarity). Required for cardiac sodium current propagation and electrical synchrony in cardiac myocytes, via ANK3 stabilization and modulation of SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). Required for mitochondrial function, nuclear envelope integrity and positive regulation of SIRT3 transcription via maintaining DES localization at its nuclear envelope and cell tip anchoring points, and thereby preserving regulation of the transcriptional program (PubMed:35959657). Maintenance of nuclear envelope integrity protects against DNA damage and transcriptional dysregulation of genes, especially those involved in the electron transport chain, thereby preserving mitochondrial function and protecting against superoxide radical anion generation (PubMed:35959657). Binds single-stranded DNA (ssDNA) (PubMed:20613778). May regulate the localization of GJA1 to gap junctions in intercalated disks of the heart (PubMed:18662195). Involved in the inhibition of viral infection by influenza A viruses (IAV) (PubMed:28169297). Acts as a host restriction factor for IAV viral propagation, potentially via disrupting the interaction of IAV polymerase complex proteins (PubMed:28169297). {ECO:0000250|UniProtKB:F1M7L9, ECO:0000250|UniProtKB:Q9CQ73, ECO:0000269|PubMed:18662195, ECO:0000269|PubMed:20613778, ECO:0000269|PubMed:22781308, ECO:0000269|PubMed:23884246, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:28169297, ECO:0000269|PubMed:34368962, ECO:0000269|PubMed:35959657}. |
| Q9BSJ8 | ESYT1 | S1067 | ochoa | Extended synaptotagmin-1 (E-Syt1) (Membrane-bound C2 domain-containing protein) | Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels (PubMed:23791178, PubMed:24183667). Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane (PubMed:24183667). Acts as an inhibitor of ADGRD1 G-protein-coupled receptor activity in absence of cytosolic calcium (PubMed:38758649). Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). {ECO:0000250|UniProtKB:A0FGR8, ECO:0000269|PubMed:23791178, ECO:0000269|PubMed:24183667, ECO:0000269|PubMed:38758649}. |
| Q9BV44 | THUMPD3 | S207 | ochoa | tRNA (guanine(6)-N(2))-methyltransferase THUMP3 (EC 2.1.1.256) (THUMP domain-containing protein 3) (tRNA(Trp) (guanine(7)-N(2))-methyltransferase THUMP3) (EC 2.1.1.-) | Catalytic subunit of the THUMPD3-TRM112 methyltransferase complex, that specifically mediates the S-adenosyl-L-methionine-dependent N(2)-methylation of guanosine nucleotide at position 6 (m2G6) in tRNAs (PubMed:34669960, PubMed:37283053). This is one of the major tRNA (guanine-N(2))-methyltransferases (PubMed:37283053). Also catalyzes the S-adenosyl-L-methionine-dependent N(2)-methylation of guanosine nucleotide at position 7 of tRNA(Trp) (PubMed:34669960). {ECO:0000269|PubMed:34669960, ECO:0000269|PubMed:37283053}. |
| Q9BX66 | SORBS1 | S705 | ochoa | Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) | Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250|UniProtKB:Q62417}. |
| Q9BXK5 | BCL2L13 | S38 | ochoa | Bcl-2-like protein 13 (Bcl2-L-13) (Bcl-rambo) (Protein Mil1) | May promote the activation of caspase-3 and apoptosis. |
| Q9HBX9 | RXFP1 | S304 | ochoa | Relaxin receptor 1 (Leucine-rich repeat-containing G-protein coupled receptor 7) (Relaxin family peptide receptor 1) | Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP. |
| Q9NP80 | PNPLA8 | S511 | psp | Calcium-independent phospholipase A2-gamma (EC 3.1.1.-) (EC 3.1.1.5) (Intracellular membrane-associated calcium-independent phospholipase A2 gamma) (iPLA2-gamma) (PNPLA-gamma) (Patatin-like phospholipase domain-containing protein 8) (iPLA2-2) | Calcium-independent and membrane-bound phospholipase, that catalyzes the esterolytic cleavage of fatty acids from glycerophospholipids to yield free fatty acids and lysophospholipids, hence regulating membrane physical properties and the release of lipid second messengers and growth factors (PubMed:10744668, PubMed:10833412, PubMed:15695510, PubMed:15908428, PubMed:17213206, PubMed:18171998, PubMed:28442572). Hydrolyzes phosphatidylethanolamine, phosphatidylcholine and probably phosphatidylinositol with a possible preference for the former (PubMed:15695510). Also has a broad substrate specificity in terms of fatty acid moieties, hydrolyzing saturated and mono-unsaturated fatty acids at nearly equal rates from either the sn-1 or sn-2 position in diacyl phosphatidylcholine (PubMed:10744668, PubMed:10833412, PubMed:15695510, PubMed:15908428). However, has a weak activity toward polyunsaturated fatty acids at the sn-2 position, and thereby favors the production of 2-arachidonoyl lysophosphatidylcholine, a key branch point metabolite in eicosanoid signaling (PubMed:15908428). On the other hand, can produce arachidonic acid from the sn-1 position of diacyl phospholipid and from the sn-2 position of arachidonate-containing plasmalogen substrates (PubMed:15908428). Therefore, plays an important role in the mobilization of arachidonic acid in response to cellular stimuli and the generation of lipid second messengers (PubMed:15695510, PubMed:15908428). Can also hydrolyze lysophosphatidylcholine (PubMed:15695510). In the mitochondrial compartment, catalyzes the hydrolysis and release of oxidized aliphatic chains from cardiolipin and integrates mitochondrial bioenergetics and signaling. It is essential for maintaining efficient bioenergetic mitochondrial function through tailoring mitochondrial membrane lipid metabolism and composition (PubMed:28442572). {ECO:0000250|UniProtKB:Q8K1N1, ECO:0000269|PubMed:10744668, ECO:0000269|PubMed:10833412, ECO:0000269|PubMed:15695510, ECO:0000269|PubMed:15908428, ECO:0000269|PubMed:17213206, ECO:0000269|PubMed:18171998, ECO:0000269|PubMed:28442572}. |
| Q9NX46 | ADPRS | S67 | ochoa | ADP-ribosylhydrolase ARH3 (ADP-ribose glycohydrolase ARH3) (ADP-ribosylhydrolase 3) (O-acetyl-ADP-ribose deacetylase ARH3) (EC 3.5.1.-) (Poly(ADP-ribose) glycohydrolase ARH3) (EC 3.2.1.143) ([Protein ADP-ribosylarginine] hydrolase-like protein 2) ([Protein ADP-ribosylserine] hydrolase) (EC 3.2.2.-) | ADP-ribosylhydrolase that preferentially hydrolyzes the scissile alpha-O-linkage attached to the anomeric C1'' position of ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on serine and threonine, free poly(ADP-ribose) and O-acetyl-ADP-D-ribose (PubMed:21498885, PubMed:29907568, PubMed:30045870, PubMed:30401461, PubMed:30830864, PubMed:33186521, PubMed:33769608, PubMed:33894202, PubMed:34019811, PubMed:34321462, PubMed:34479984, PubMed:34625544). Specifically acts as a serine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to serine residues on proteins, thereby playing a key role in DNA damage response (PubMed:28650317, PubMed:29234005, PubMed:30045870, PubMed:33186521, PubMed:34019811, PubMed:34625544). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:29480802, PubMed:33186521, PubMed:34625544). Does not hydrolyze ADP-ribosyl-arginine, -cysteine, -diphthamide, or -asparagine bonds (PubMed:16278211, PubMed:33769608). Also able to degrade protein free poly(ADP-ribose), which is synthesized in response to DNA damage: free poly(ADP-ribose) acts as a potent cell death signal and its degradation by ADPRHL2 protects cells from poly(ADP-ribose)-dependent cell death, a process named parthanatos (PubMed:16278211). Also hydrolyzes free poly(ADP-ribose) in mitochondria (PubMed:22433848). Specifically digests O-acetyl-ADP-D-ribose, a product of deacetylation reactions catalyzed by sirtuins (PubMed:17075046, PubMed:21498885). Specifically degrades 1''-O-acetyl-ADP-D-ribose isomer, rather than 2''-O-acetyl-ADP-D-ribose or 3''-O-acetyl-ADP-D-ribose isomers (PubMed:21498885). {ECO:0000269|PubMed:16278211, ECO:0000269|PubMed:17075046, ECO:0000269|PubMed:21498885, ECO:0000269|PubMed:22433848, ECO:0000269|PubMed:28650317, ECO:0000269|PubMed:29234005, ECO:0000269|PubMed:29480802, ECO:0000269|PubMed:29907568, ECO:0000269|PubMed:30045870, ECO:0000269|PubMed:30401461, ECO:0000269|PubMed:30830864, ECO:0000269|PubMed:33186521, ECO:0000269|PubMed:33769608, ECO:0000269|PubMed:33894202, ECO:0000269|PubMed:34019811, ECO:0000269|PubMed:34321462, ECO:0000269|PubMed:34479984, ECO:0000269|PubMed:34625544}. |
| Q9P0K7 | RAI14 | S239 | ochoa | Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14) | Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier. {ECO:0000250|UniProtKB:Q5U312}. |
| Q9UHF7 | TRPS1 | S368 | ochoa | Zinc finger transcription factor Trps1 (Tricho-rhino-phalangeal syndrome type I protein) (Zinc finger protein GC79) | Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes. {ECO:0000269|PubMed:12885770, ECO:0000269|PubMed:17391059}. |
| Q9UKT8 | FBXW2 | S243 | ochoa | F-box/WD repeat-containing protein 2 (F-box and WD-40 domain-containing protein 2) (Protein MD6) | Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. |
| Q9UPQ9 | TNRC6B | S1504 | ochoa | Trinucleotide repeat-containing gene 6B protein | Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs) (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). As scaffolding protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes (PubMed:21981923). {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:19167051, ECO:0000269|PubMed:19304925, ECO:0000269|PubMed:21981923, ECO:0000269|PubMed:32354837}. |
| Q9Y490 | TLN1 | S2096 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| P08195 | SLC3A2 | S253 | Sugiyama | Amino acid transporter heavy chain SLC3A2 (4F2 cell-surface antigen heavy chain) (4F2hc) (4F2 heavy chain antigen) (Lymphocyte activation antigen 4F2 large subunit) (Solute carrier family 3 member 2) (CD antigen CD98) | Acts as a chaperone that facilitates biogenesis and trafficking of functional transporters heterodimers to the plasma membrane. Forms heterodimer with SLC7 family transporters (SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A10 and SLC7A11), a group of amino-acid antiporters (PubMed:10574970, PubMed:10903140, PubMed:11557028, PubMed:30867591, PubMed:33298890, PubMed:33758168, PubMed:34880232, PubMed:9751058, PubMed:9829974, PubMed:9878049). Heterodimers function as amino acids exchangers, the specificity of the substrate depending on the SLC7A subunit. Heterodimers SLC3A2/SLC7A6 or SLC3A2/SLC7A7 mediate the uptake of dibasic amino acids (PubMed:10903140, PubMed:9829974). Heterodimer SLC3A2/SLC7A11 functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane (PubMed:34880232). SLC3A2/SLC7A10 translocates small neutral L- and D-amino acids across the plasma membrane (By similarity). SLC3A2/SLC75 or SLC3A2/SLC7A8 translocates neutral amino acids with broad specificity, thyroid hormones and L-DOPA (PubMed:10574970, PubMed:11389679, PubMed:11557028, PubMed:11564694, PubMed:11742812, PubMed:12117417, PubMed:12225859, PubMed:12716892, PubMed:15980244, PubMed:30867591, PubMed:33298890, PubMed:33758168). SLC3A2 is essential for plasma membrane localization, stability, and the transport activity of SLC7A5 and SLC7A8 (PubMed:10391915, PubMed:10574970, PubMed:11311135, PubMed:15769744, PubMed:33066406). When associated with LAPTM4B, the heterodimer SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation (PubMed:25998567). Modulates integrin-related signaling and is essential for integrin-dependent cell spreading, migration and tumor progression (PubMed:11121428, PubMed:15625115). {ECO:0000250|UniProtKB:P63115, ECO:0000269|PubMed:10391915, ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:10903140, ECO:0000269|PubMed:11121428, ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:11389679, ECO:0000269|PubMed:11557028, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:11742812, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:12716892, ECO:0000269|PubMed:15625115, ECO:0000269|PubMed:15769744, ECO:0000269|PubMed:15980244, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:33066406, ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:33758168, ECO:0000269|PubMed:34880232, ECO:0000269|PubMed:9751058, ECO:0000269|PubMed:9829974, ECO:0000269|PubMed:9878049}.; FUNCTION: (Microbial infection) In case of hepatitis C virus/HCV infection, the complex formed by SLC3A2 and SLC7A5/LAT1 plays a role in HCV propagation by facilitating viral entry into host cell and increasing L-leucine uptake-mediated mTORC1 signaling activation, thereby contributing to HCV-mediated pathogenesis. {ECO:0000269|PubMed:30341327}.; FUNCTION: (Microbial infection) Acts as a receptor for malaria parasite Plasmodium vivax (Thai isolate) in immature red blood cells. {ECO:0000269|PubMed:34294905}. |
| Q06323 | PSME1 | S31 | Sugiyama | Proteasome activator complex subunit 1 (11S regulator complex subunit alpha) (REG-alpha) (Activator of multicatalytic protease subunit 1) (Interferon gamma up-regulated I-5111 protein) (IGUP I-5111) (Proteasome activator 28 subunit alpha) (PA28a) (PA28alpha) | Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome. |
| P45983 | MAPK8 | T243 | Sugiyama | Mitogen-activated protein kinase 8 (MAP kinase 8) (MAPK 8) (EC 2.7.11.24) (JNK-46) (Stress-activated protein kinase 1c) (SAPK1c) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) | Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway (PubMed:28943315). In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity (PubMed:18307971). Phosphorylates the replication licensing factor CDT1, inhibiting the interaction between CDT1 and the histone H4 acetylase HBO1 to replication origins (PubMed:21856198). Loss of this interaction abrogates the acetylation required for replication initiation (PubMed:21856198). Promotes stressed cell apoptosis by phosphorylating key regulatory factors including p53/TP53 and Yes-associates protein YAP1 (PubMed:21364637). In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Contributes to the survival of erythroid cells by phosphorylating the antagonist of cell death BAD upon EPO stimulation (PubMed:21095239). Mediates starvation-induced BCL2 phosphorylation, BCL2 dissociation from BECN1, and thus activation of autophagy (PubMed:18570871). Phosphorylates STMN2 and hence regulates microtubule dynamics, controlling neurite elongation in cortical neurons (By similarity). In the developing brain, through its cytoplasmic activity on STMN2, negatively regulates the rate of exit from multipolar stage and of radial migration from the ventricular zone (By similarity). Phosphorylates several other substrates including heat shock factor protein 4 (HSF4), the deacetylase SIRT1, ELK1, or the E3 ligase ITCH (PubMed:16581800, PubMed:17296730, PubMed:20027304). Phosphorylates the CLOCK-BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692). Phosphorylates the heat shock transcription factor HSF1, suppressing HSF1-induced transcriptional activity (PubMed:10747973). Phosphorylates POU5F1, which results in the inhibition of POU5F1's transcriptional activity and enhances its proteasomal degradation (By similarity). Phosphorylates JUND and this phosphorylation is inhibited in the presence of MEN1 (PubMed:22327296). In neurons, phosphorylates SYT4 which captures neuronal dense core vesicles at synapses (By similarity). Phosphorylates EIF4ENIF1/4-ET in response to oxidative stress, promoting P-body assembly (PubMed:22966201). Phosphorylates SIRT6 in response to oxidative stress, stimulating its mono-ADP-ribosyltransferase activity (PubMed:27568560). Phosphorylates NLRP3, promoting assembly of the NLRP3 inflammasome (PubMed:28943315). Phosphorylates ALKBH5 in response to reactive oxygen species (ROS), promoting ALKBH5 sumoylation and inactivation (PubMed:34048572). {ECO:0000250|UniProtKB:P49185, ECO:0000250|UniProtKB:Q91Y86, ECO:0000269|PubMed:10747973, ECO:0000269|PubMed:16581800, ECO:0000269|PubMed:17296730, ECO:0000269|PubMed:18307971, ECO:0000269|PubMed:18570871, ECO:0000269|PubMed:20027304, ECO:0000269|PubMed:21095239, ECO:0000269|PubMed:21364637, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:22327296, ECO:0000269|PubMed:22441692, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:27568560, ECO:0000269|PubMed:28943315, ECO:0000269|PubMed:34048572}.; FUNCTION: JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. |
| P53779 | MAPK10 | T281 | Sugiyama | Mitogen-activated protein kinase 10 (MAP kinase 10) (MAPK 10) (EC 2.7.11.24) (MAP kinase p49 3F12) (Stress-activated protein kinase 1b) (SAPK1b) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) | Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the amyloid-beta precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Also participates in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock (PubMed:22441692). Phosphorylates JUND and this phosphorylation is inhibited in the presence of MEN1 (PubMed:22327296). {ECO:0000269|PubMed:11718727, ECO:0000269|PubMed:22327296, ECO:0000269|PubMed:22441692}. |
| P51957 | NEK4 | S720 | Sugiyama | Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) | Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage. {ECO:0000250|UniProtKB:Q9Z1J2, ECO:0000269|PubMed:22851694}. |
| O14910 | LIN7A | S157 | Sugiyama | Protein lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Tax interaction protein 33) (TIP-33) (Vertebrate lin-7 homolog 1) (Veli-1) | Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. {ECO:0000250|UniProtKB:Q8JZS0, ECO:0000269|PubMed:12967566}. |
| Q9NUP9 | LIN7C | S142 | Sugiyama | Protein lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3) | Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. {ECO:0000250|UniProtKB:O88952}. |
| P00451 | F8 | S1656 | SIGNOR | Coagulation factor VIII (Antihemophilic factor) (AHF) (Procoagulant component) [Cleaved into: Factor VIIIa heavy chain, 200 kDa isoform; Factor VIIIa heavy chain, 92 kDa isoform; Factor VIII B chain; Factor VIIIa light chain] | Factor VIII, along with calcium and phospholipid, acts as a cofactor for F9/factor IXa when it converts F10/factor X to the activated form, factor Xa. |
| Q96J92 | WNK4 | S316 | Sugiyama | Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase lysine-deficient 4) (Protein kinase with no lysine 4) | Serine/threonine-protein kinase component of the WNK4-SPAK/OSR1 kinase cascade, which acts as a key regulator of ion transport in the distal nephron and blood pressure (By similarity). The WNK4-SPAK/OSR1 kinase cascade is composed of WNK4, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:16832045). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:16832045, PubMed:22989884). Acts as a molecular switch that regulates the balance between renal salt reabsorption and K(+) secretion by modulating the activities of renal transporters and channels, including the Na-Cl cotransporter SLC12A3/NCC and the K(+) channel, KCNJ1/ROMK (By similarity). Regulates NaCl reabsorption in the distal nephron by activating the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney: activates SLC12A3/NCC in a OXSR1/OSR1- and STK39/SPAK-dependent process (By similarity). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels (CFTR, KCNJ1/ROMK, SLC4A4, SLC26A9 and TRPV4) by clathrin-dependent endocytosis (By similarity). Also inhibits the activity of the epithelial Na(+) channel (ENaC) SCNN1A, SCNN1B, SCNN1D in a inase-independent mechanism (By similarity). May also phosphorylate NEDD4L (PubMed:20525693). {ECO:0000250|UniProtKB:Q80UE6, ECO:0000269|PubMed:16832045, ECO:0000269|PubMed:20525693, ECO:0000269|PubMed:22989884}. |
| P14868 | DARS1 | S192 | Sugiyama | Aspartate--tRNA ligase, cytoplasmic (EC 6.1.1.12) (Aspartyl-tRNA synthetase) (AspRS) (Cell proliferation-inducing gene 40 protein) | Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. {ECO:0000250|UniProtKB:P15178}. |
| Q86UP3 | ZFHX4 | S314 | Sugiyama | Zinc finger homeobox protein 4 (Zinc finger homeodomain protein 4) (ZFH-4) | May play a role in neural and muscle differentiation (By similarity). May be involved in transcriptional regulation. {ECO:0000250}. |
| Q9NWZ3 | IRAK4 | S314 | Sugiyama | Interleukin-1 receptor-associated kinase 4 (IRAK-4) (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-64) | Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways (PubMed:17878374). Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections. {ECO:0000269|PubMed:11960013, ECO:0000269|PubMed:12538665, ECO:0000269|PubMed:15084582, ECO:0000269|PubMed:17217339, ECO:0000269|PubMed:17337443, ECO:0000269|PubMed:17878374, ECO:0000269|PubMed:17997719, ECO:0000269|PubMed:20400509, ECO:0000269|PubMed:24316379}. |
| P20794 | MAK | T218 | Sugiyama | Serine/threonine-protein kinase MAK (EC 2.7.11.1) (Male germ cell-associated kinase) | Essential for the regulation of ciliary length and required for the long-term survival of photoreceptors (By similarity). Phosphorylates FZR1 in a cell cycle-dependent manner. Plays a role in the transcriptional coactivation of AR. Could play an important function in spermatogenesis. May play a role in chromosomal stability in prostate cancer cells. {ECO:0000250, ECO:0000269|PubMed:12084720, ECO:0000269|PubMed:16951154, ECO:0000269|PubMed:21986944}. |
| Q9UQ07 | MOK | T220 | Sugiyama | MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase) (Renal tumor antigen 1) (RAGE-1) | Able to phosphorylate several exogenous substrates and to undergo autophosphorylation. Negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner. {ECO:0000250|UniProtKB:Q9WVS4}. |
| Q9BYP7 | WNK3 | S289 | Sugiyama | Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase lysine-deficient 3) (Protein kinase with no lysine 3) | Serine/threonine-protein kinase component of the WNK3-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis and regulatory volume increase in response to hyperosmotic stress (PubMed:16275911, PubMed:16275913, PubMed:16501604, PubMed:22989884, PubMed:36318922). WNK3 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK3 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK3-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:22989884). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A4/KCC1, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:16275911, PubMed:16275913). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A4/KCC1, SLC12A5/KCC2 and SLC12A6/KCC3 inhibits its activity, blocking ion efflux (PubMed:16275911, PubMed:16275913, PubMed:16357011, PubMed:19470686, PubMed:21613606). Phosphorylates WNK4, possibly regulating the activity of SLC12A3/NCC (PubMed:17975670). May also phosphorylate NEDD4L (PubMed:20525693). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as KCNJ1 and SLC26A9 (PubMed:16357011, PubMed:17673510). Increases Ca(2+) influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase-dependent pathway (PubMed:18768590). {ECO:0000269|PubMed:16275911, ECO:0000269|PubMed:16275913, ECO:0000269|PubMed:16357011, ECO:0000269|PubMed:16501604, ECO:0000269|PubMed:17673510, ECO:0000269|PubMed:17975670, ECO:0000269|PubMed:18768590, ECO:0000269|PubMed:19470686, ECO:0000269|PubMed:20525693, ECO:0000269|PubMed:21613606, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:36318922}. |
| Q9H4A3 | WNK1 | S363 | Sugiyama | Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1) | Serine/threonine-protein kinase component of the WNK1-SPAK/OSR1 kinase cascade, which acts as a key regulator of blood pressure and regulatory volume increase by promoting ion influx (PubMed:15883153, PubMed:17190791, PubMed:31656913, PubMed:34289367, PubMed:36318922). WNK1 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK1 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK1-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:15883153, PubMed:16263722, PubMed:17190791, PubMed:19739668, PubMed:21321328, PubMed:22989884, PubMed:25477473, PubMed:34289367, PubMed:36318922). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A5/KCC2 and SLC12A6/KCC3, regulating their activity (PubMed:16263722, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:19665974, PubMed:21321328). Also acts as a regulator of angiogenesis in endothelial cells via activation of OXSR1/OSR1 and STK39/SPAK: activation of OXSR1/OSR1 regulates chemotaxis and invasion, while STK39/SPAK regulates endothelial cell proliferation (PubMed:25362046). Also acts independently of the WNK1-SPAK/OSR1 kinase cascade by catalyzing phosphorylation of other substrates, such as SYT2, PCF11 and NEDD4L (PubMed:29196535). Mediates phosphorylation of SYT2, regulating SYT2 association with phospholipids and membrane-binding (By similarity). Regulates mRNA export in the nucleus by mediating phosphorylation of PCF11, thereby decreasing the association between PCF11 and POLR2A/RNA polymerase II and promoting mRNA export to the cytoplasm (PubMed:29196535). Acts as a negative regulator of autophagy (PubMed:27911840). Required for the abscission step during mitosis, independently of the WNK1-SPAK/OSR1 kinase cascade (PubMed:21220314). May also play a role in actin cytoskeletal reorganization (PubMed:10660600). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as SLC4A4, SLC26A6, SLC26A9, TRPV4 and CFTR (By similarity). Involved in the regulation of epithelial Na(+) channel (ENaC) by promoting activation of SGK1 in a kinase-independent manner: probably acts as a scaffold protein that promotes the recruitment of SGK1 to the mTORC2 complex in response to chloride, leading to mTORC2-dependent phosphorylation and activation of SGK1 (PubMed:36373794). Acts as an assembly factor for the ER membrane protein complex independently of its protein kinase activity: associates with EMC2 in the cytoplasm via its amphipathic alpha-helix, and prevents EMC2 ubiquitination and subsequent degradation, thereby promoting EMC2 stabilization (PubMed:33964204). {ECO:0000250|UniProtKB:P83741, ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:15883153, ECO:0000269|PubMed:16263722, ECO:0000269|PubMed:17190791, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:19739668, ECO:0000269|PubMed:21220314, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:25477473, ECO:0000269|PubMed:27911840, ECO:0000269|PubMed:29196535, ECO:0000269|PubMed:31656913, ECO:0000269|PubMed:33964204, ECO:0000269|PubMed:34289367, ECO:0000269|PubMed:36318922, ECO:0000269|PubMed:36373794}.; FUNCTION: [Isoform 3]: Kinase-defective isoform specifically expressed in kidney, which acts as a dominant-negative regulator of the longer isoform 1 (PubMed:14645531). Does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport (By similarity). Down-regulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity (By similarity). In kidney, may play an important role regulating sodium and potassium balance (By similarity). {ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:14645531}. |
| Q9Y3S1 | WNK2 | S337 | Sugiyama | Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Antigen NY-CO-43) (Protein kinase lysine-deficient 2) (Protein kinase with no lysine 2) (Serologically defined colon cancer antigen 43) | Serine/threonine-protein kinase component of the WNK2-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation (PubMed:17667937, PubMed:18593598, PubMed:21733846). The WNK2-SPAK/OSR1 kinase cascade is composed of WNK2, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (By similarity). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, regulating their activity (By similarity). Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:21733846). Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5 (PubMed:21733846). Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression (PubMed:17667937, PubMed:18593598). Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1 (PubMed:17667937, PubMed:18593598). WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity (PubMed:17667937, PubMed:18593598). {ECO:0000250|UniProtKB:Q9H4A3, ECO:0000269|PubMed:17667937, ECO:0000269|PubMed:18593598, ECO:0000269|PubMed:21733846}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 1.147756e-09 | 8.940 |
| R-HSA-5674135 | MAP2K and MAPK activation | 2.638402e-09 | 8.579 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 2.638402e-09 | 8.579 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 5.577865e-09 | 8.254 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 5.577865e-09 | 8.254 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 5.577865e-09 | 8.254 |
| R-HSA-6802949 | Signaling by RAS mutants | 5.577865e-09 | 8.254 |
| R-HSA-450341 | Activation of the AP-1 family of transcription factors | 2.884932e-08 | 7.540 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 5.579376e-08 | 7.253 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 2.857915e-07 | 6.544 |
| R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 3.624541e-07 | 6.441 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 3.452093e-07 | 6.462 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 1.087151e-06 | 5.964 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 1.087151e-06 | 5.964 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 2.951887e-06 | 5.530 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 5.362892e-06 | 5.271 |
| R-HSA-418990 | Adherens junctions interactions | 7.143743e-06 | 5.146 |
| R-HSA-9764561 | Regulation of CDH1 Function | 7.177005e-06 | 5.144 |
| R-HSA-446728 | Cell junction organization | 8.219292e-06 | 5.085 |
| R-HSA-421270 | Cell-cell junction organization | 2.164087e-05 | 4.665 |
| R-HSA-1500931 | Cell-Cell communication | 2.471659e-05 | 4.607 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 2.670096e-05 | 4.573 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 2.812223e-05 | 4.551 |
| R-HSA-9732724 | IFNG signaling activates MAPKs | 5.188553e-05 | 4.285 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 5.188553e-05 | 4.285 |
| R-HSA-5683057 | MAPK family signaling cascades | 5.456522e-05 | 4.263 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 6.871100e-05 | 4.163 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 6.871100e-05 | 4.163 |
| R-HSA-445355 | Smooth Muscle Contraction | 7.473331e-05 | 4.126 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 7.760332e-05 | 4.110 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 9.618534e-05 | 4.017 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 1.149444e-04 | 3.940 |
| R-HSA-450294 | MAP kinase activation | 1.324379e-04 | 3.878 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 1.246990e-04 | 3.904 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 1.246990e-04 | 3.904 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 1.246990e-04 | 3.904 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 1.513740e-04 | 3.820 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 2.182006e-04 | 3.661 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 2.087662e-04 | 3.680 |
| R-HSA-187687 | Signalling to ERKs | 2.296218e-04 | 3.639 |
| R-HSA-448424 | Interleukin-17 signaling | 2.326893e-04 | 3.633 |
| R-HSA-170968 | Frs2-mediated activation | 2.460483e-04 | 3.609 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 2.460483e-04 | 3.609 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 2.593524e-04 | 3.586 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 2.940404e-04 | 3.532 |
| R-HSA-373760 | L1CAM interactions | 3.191192e-04 | 3.496 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 3.280248e-04 | 3.484 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 3.598510e-04 | 3.444 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 3.598510e-04 | 3.444 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 3.400542e-04 | 3.468 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 3.400542e-04 | 3.468 |
| R-HSA-169893 | Prolonged ERK activation events | 3.946255e-04 | 3.404 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 4.045463e-04 | 3.393 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 4.045463e-04 | 3.393 |
| R-HSA-1640170 | Cell Cycle | 5.570508e-04 | 3.254 |
| R-HSA-437239 | Recycling pathway of L1 | 6.301414e-04 | 3.201 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 6.736472e-04 | 3.172 |
| R-HSA-9652169 | Signaling by MAP2K mutants | 8.397536e-04 | 3.076 |
| R-HSA-198753 | ERK/MAPK targets | 8.411549e-04 | 3.075 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 8.411549e-04 | 3.075 |
| R-HSA-1474244 | Extracellular matrix organization | 8.119081e-04 | 3.090 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 1.040053e-03 | 2.983 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 1.131641e-03 | 2.946 |
| R-HSA-397014 | Muscle contraction | 1.250889e-03 | 2.903 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 1.281873e-03 | 2.892 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 1.427269e-03 | 2.845 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 1.536628e-03 | 2.813 |
| R-HSA-9700206 | Signaling by ALK in cancer | 1.536628e-03 | 2.813 |
| R-HSA-2672351 | Stimuli-sensing channels | 1.593563e-03 | 2.798 |
| R-HSA-9842640 | Signaling by LTK in cancer | 1.863908e-03 | 2.730 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 1.806804e-03 | 2.743 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 1.961084e-03 | 2.708 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 1.712070e-03 | 2.766 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 1.712070e-03 | 2.766 |
| R-HSA-68886 | M Phase | 2.090452e-03 | 2.680 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 2.470647e-03 | 2.607 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 2.659278e-03 | 2.575 |
| R-HSA-69278 | Cell Cycle, Mitotic | 2.689639e-03 | 2.570 |
| R-HSA-196025 | Formation of annular gap junctions | 2.759243e-03 | 2.559 |
| R-HSA-444257 | RSK activation | 2.759243e-03 | 2.559 |
| R-HSA-2559583 | Cellular Senescence | 2.795560e-03 | 2.554 |
| R-HSA-5673000 | RAF activation | 3.058894e-03 | 2.514 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 3.058894e-03 | 2.514 |
| R-HSA-190873 | Gap junction degradation | 3.268897e-03 | 2.486 |
| R-HSA-2559585 | Oncogene Induced Senescence | 3.271774e-03 | 2.485 |
| R-HSA-110056 | MAPK3 (ERK1) activation | 3.819097e-03 | 2.418 |
| R-HSA-74749 | Signal attenuation | 3.819097e-03 | 2.418 |
| R-HSA-168898 | Toll-like Receptor Cascades | 3.632061e-03 | 2.440 |
| R-HSA-9627069 | Regulation of the apoptosome activity | 3.819097e-03 | 2.418 |
| R-HSA-111458 | Formation of apoptosome | 3.819097e-03 | 2.418 |
| R-HSA-9635465 | Suppression of apoptosis | 4.409267e-03 | 2.356 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 4.994260e-03 | 2.302 |
| R-HSA-9664407 | Parasite infection | 4.994260e-03 | 2.302 |
| R-HSA-9664417 | Leishmania phagocytosis | 4.994260e-03 | 2.302 |
| R-HSA-202670 | ERKs are inactivated | 5.038835e-03 | 2.298 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 5.038835e-03 | 2.298 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 5.038835e-03 | 2.298 |
| R-HSA-111461 | Cytochrome c-mediated apoptotic response | 5.038835e-03 | 2.298 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 5.127434e-03 | 2.290 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 5.427856e-03 | 2.265 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 5.707238e-03 | 2.244 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 6.413917e-03 | 2.193 |
| R-HSA-5654743 | Signaling by FGFR4 | 5.599888e-03 | 2.252 |
| R-HSA-422475 | Axon guidance | 6.267994e-03 | 2.203 |
| R-HSA-5654741 | Signaling by FGFR3 | 6.222371e-03 | 2.206 |
| R-HSA-2682334 | EPH-Ephrin signaling | 5.813761e-03 | 2.236 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 5.906201e-03 | 2.229 |
| R-HSA-9672387 | Defective F8 accelerates dissociation of the A2 domain | 6.931309e-03 | 2.159 |
| R-HSA-9672395 | Defective F8 binding to the cell membrane | 6.931309e-03 | 2.159 |
| R-HSA-9672397 | Defective F8 secretion | 6.931309e-03 | 2.159 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 7.265698e-03 | 2.139 |
| R-HSA-1502540 | Signaling by Activin | 7.939895e-03 | 2.100 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 8.265313e-03 | 2.083 |
| R-HSA-162582 | Signal Transduction | 8.680346e-03 | 2.061 |
| R-HSA-6794361 | Neurexins and neuroligins | 8.717898e-03 | 2.060 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 8.717898e-03 | 2.060 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 8.758105e-03 | 2.058 |
| R-HSA-9675108 | Nervous system development | 9.552040e-03 | 2.020 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 9.612413e-03 | 2.017 |
| R-HSA-157118 | Signaling by NOTCH | 9.920760e-03 | 2.003 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 1.013261e-02 | 1.994 |
| R-HSA-5654736 | Signaling by FGFR1 | 1.037157e-02 | 1.984 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 1.037157e-02 | 1.984 |
| R-HSA-9672393 | Defective F8 binding to von Willebrand factor | 1.381500e-02 | 1.860 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 1.440704e-02 | 1.841 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 1.162141e-02 | 1.935 |
| R-HSA-140837 | Intrinsic Pathway of Fibrin Clot Formation | 1.440704e-02 | 1.841 |
| R-HSA-68875 | Mitotic Prophase | 1.464165e-02 | 1.834 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 1.126196e-02 | 1.948 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 1.131306e-02 | 1.946 |
| R-HSA-445144 | Signal transduction by L1 | 1.338009e-02 | 1.874 |
| R-HSA-140875 | Common Pathway of Fibrin Clot Formation | 1.338009e-02 | 1.874 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 1.153670e-02 | 1.938 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 1.238665e-02 | 1.907 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 1.290877e-02 | 1.889 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 1.219521e-02 | 1.914 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 1.142721e-02 | 1.942 |
| R-HSA-1181150 | Signaling by NODAL | 1.338009e-02 | 1.874 |
| R-HSA-111471 | Apoptotic factor-mediated response | 1.142721e-02 | 1.942 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 1.546699e-02 | 1.811 |
| R-HSA-983712 | Ion channel transport | 1.546915e-02 | 1.811 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 1.574875e-02 | 1.803 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 1.655943e-02 | 1.781 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 1.655943e-02 | 1.781 |
| R-HSA-194138 | Signaling by VEGF | 1.690727e-02 | 1.772 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 1.751422e-02 | 1.757 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 1.768388e-02 | 1.752 |
| R-HSA-982772 | Growth hormone receptor signaling | 1.768388e-02 | 1.752 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 1.810659e-02 | 1.742 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 1.811789e-02 | 1.742 |
| R-HSA-199991 | Membrane Trafficking | 1.850544e-02 | 1.733 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 1.871002e-02 | 1.728 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 1.895423e-02 | 1.722 |
| R-HSA-9824443 | Parasitic Infection Pathways | 1.905869e-02 | 1.720 |
| R-HSA-9658195 | Leishmania infection | 1.905869e-02 | 1.720 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 1.932454e-02 | 1.714 |
| R-HSA-9013694 | Signaling by NOTCH4 | 1.995015e-02 | 1.700 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 2.124440e-02 | 1.673 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 2.124440e-02 | 1.673 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 2.189361e-02 | 1.660 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 2.249204e-02 | 1.648 |
| R-HSA-913531 | Interferon Signaling | 2.316751e-02 | 1.635 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 2.744083e-02 | 1.562 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 2.744083e-02 | 1.562 |
| R-HSA-9672383 | Defective factor IX causes thrombophilia | 2.744083e-02 | 1.562 |
| R-HSA-9672396 | Defective cofactor function of FVIIIa variant | 2.744083e-02 | 1.562 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 2.744083e-02 | 1.562 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 2.744083e-02 | 1.562 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 2.744083e-02 | 1.562 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 2.744083e-02 | 1.562 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 2.744083e-02 | 1.562 |
| R-HSA-9674519 | Defective F8 sulfation at Y1699 | 2.744083e-02 | 1.562 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 2.744083e-02 | 1.562 |
| R-HSA-9673202 | Defective F9 variant does not activate FX | 2.744083e-02 | 1.562 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 2.744083e-02 | 1.562 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 2.744083e-02 | 1.562 |
| R-HSA-9672391 | Defective F8 cleavage by thrombin | 2.744083e-02 | 1.562 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 2.744083e-02 | 1.562 |
| R-HSA-5603037 | IRAK4 deficiency (TLR5) | 3.418360e-02 | 1.466 |
| R-HSA-5660862 | Defective SLC7A7 causes lysinuric protein intolerance (LPI) | 3.418360e-02 | 1.466 |
| R-HSA-8941237 | Invadopodia formation | 3.418360e-02 | 1.466 |
| R-HSA-390522 | Striated Muscle Contraction | 3.202922e-02 | 1.494 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 3.499905e-02 | 1.456 |
| R-HSA-446343 | Localization of the PINCH-ILK-PARVIN complex to focal adhesions | 2.744083e-02 | 1.562 |
| R-HSA-139910 | Activation of BMF and translocation to mitochondria | 3.418360e-02 | 1.466 |
| R-HSA-111446 | Activation of BIM and translocation to mitochondria | 3.418360e-02 | 1.466 |
| R-HSA-456926 | Thrombin signalling through proteinase activated receptors (PARs) | 2.641082e-02 | 1.578 |
| R-HSA-390650 | Histamine receptors | 3.418360e-02 | 1.466 |
| R-HSA-68882 | Mitotic Anaphase | 2.502256e-02 | 1.602 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 2.542050e-02 | 1.595 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 2.393707e-02 | 1.621 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 3.058381e-02 | 1.515 |
| R-HSA-166520 | Signaling by NTRKs | 2.918994e-02 | 1.535 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 3.310841e-02 | 1.480 |
| R-HSA-9833482 | PKR-mediated signaling | 2.393707e-02 | 1.621 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 3.030628e-02 | 1.518 |
| R-HSA-1538133 | G0 and Early G1 | 2.916531e-02 | 1.535 |
| R-HSA-2262752 | Cellular responses to stress | 2.870666e-02 | 1.542 |
| R-HSA-8964539 | Glutamate and glutamine metabolism | 3.202922e-02 | 1.494 |
| R-HSA-1266738 | Developmental Biology | 2.989675e-02 | 1.524 |
| R-HSA-5654738 | Signaling by FGFR2 | 2.393707e-02 | 1.621 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 2.756494e-02 | 1.560 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 3.350111e-02 | 1.475 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 2.347107e-02 | 1.629 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 2.376930e-02 | 1.624 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 2.916531e-02 | 1.535 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 3.652262e-02 | 1.437 |
| R-HSA-69205 | G1/S-Specific Transcription | 3.652262e-02 | 1.437 |
| R-HSA-8941326 | RUNX2 regulates bone development | 3.652262e-02 | 1.437 |
| R-HSA-8948216 | Collagen chain trimerization | 3.807139e-02 | 1.419 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 3.807139e-02 | 1.419 |
| R-HSA-1251932 | PLCG1 events in ERBB2 signaling | 4.088005e-02 | 1.388 |
| R-HSA-1306955 | GRB7 events in ERBB2 signaling | 4.088005e-02 | 1.388 |
| R-HSA-2644607 | Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling | 4.088005e-02 | 1.388 |
| R-HSA-2644605 | FBXW7 Mutants and NOTCH1 in Cancer | 4.088005e-02 | 1.388 |
| R-HSA-5083630 | Defective LFNG causes SCDO3 | 4.088005e-02 | 1.388 |
| R-HSA-165181 | Inhibition of TSC complex formation by PKB | 4.088005e-02 | 1.388 |
| R-HSA-9007892 | Interleukin-38 signaling | 4.088005e-02 | 1.388 |
| R-HSA-190236 | Signaling by FGFR | 4.102269e-02 | 1.387 |
| R-HSA-70171 | Glycolysis | 4.289993e-02 | 1.368 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 4.451026e-02 | 1.352 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 4.481970e-02 | 1.349 |
| R-HSA-69620 | Cell Cycle Checkpoints | 4.534275e-02 | 1.343 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 4.617891e-02 | 1.336 |
| R-HSA-426496 | Post-transcriptional silencing by small RNAs | 4.753047e-02 | 1.323 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 4.787033e-02 | 1.320 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 4.958414e-02 | 1.305 |
| R-HSA-211000 | Gene Silencing by RNA | 5.083122e-02 | 1.294 |
| R-HSA-190828 | Gap junction trafficking | 5.131995e-02 | 1.290 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 5.131995e-02 | 1.290 |
| R-HSA-9824272 | Somitogenesis | 5.307737e-02 | 1.275 |
| R-HSA-2660826 | Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | 5.413519e-02 | 1.267 |
| R-HSA-2660825 | Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | 5.413519e-02 | 1.267 |
| R-HSA-9652817 | Signaling by MAPK mutants | 5.413519e-02 | 1.267 |
| R-HSA-176417 | Phosphorylation of Emi1 | 5.413519e-02 | 1.267 |
| R-HSA-187706 | Signalling to p38 via RIT and RIN | 5.413519e-02 | 1.267 |
| R-HSA-444821 | Relaxin receptors | 5.413519e-02 | 1.267 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 5.413519e-02 | 1.267 |
| R-HSA-109582 | Hemostasis | 5.429883e-02 | 1.265 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 5.485605e-02 | 1.261 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 5.509016e-02 | 1.259 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 5.665559e-02 | 1.247 |
| R-HSA-157858 | Gap junction trafficking and regulation | 6.031581e-02 | 1.220 |
| R-HSA-9662001 | Defective factor VIII causes hemophilia A | 6.069452e-02 | 1.217 |
| R-HSA-69478 | G2/M DNA replication checkpoint | 6.069452e-02 | 1.217 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 6.069452e-02 | 1.217 |
| R-HSA-426486 | Small interfering RNA (siRNA) biogenesis | 6.069452e-02 | 1.217 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 6.069452e-02 | 1.217 |
| R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 | 6.069452e-02 | 1.217 |
| R-HSA-447043 | Neurofascin interactions | 6.069452e-02 | 1.217 |
| R-HSA-8953897 | Cellular responses to stimuli | 6.187324e-02 | 1.208 |
| R-HSA-72731 | Recycling of eIF2:GDP | 6.720877e-02 | 1.173 |
| R-HSA-1912399 | Pre-NOTCH Processing in the Endoplasmic Reticulum | 6.720877e-02 | 1.173 |
| R-HSA-9768778 | Regulation of NPAS4 mRNA translation | 7.367823e-02 | 1.133 |
| R-HSA-112411 | MAPK1 (ERK2) activation | 8.010323e-02 | 1.096 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 8.648406e-02 | 1.063 |
| R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | 9.282102e-02 | 1.032 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 1.053645e-01 | 0.977 |
| R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer | 1.053645e-01 | 0.977 |
| R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants | 1.053645e-01 | 0.977 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 1.177361e-01 | 0.929 |
| R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 1.238582e-01 | 0.907 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 1.238582e-01 | 0.907 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 6.595358e-02 | 1.181 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 6.787074e-02 | 1.168 |
| R-HSA-72649 | Translation initiation complex formation | 6.980627e-02 | 1.156 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 7.373108e-02 | 1.132 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 7.175983e-02 | 1.144 |
| R-HSA-164940 | Nef mediated downregulation of MHC class I complex cell surface expression | 7.367823e-02 | 1.133 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 7.373108e-02 | 1.132 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 1.053645e-01 | 0.977 |
| R-HSA-204005 | COPII-mediated vesicle transport | 1.030058e-01 | 0.987 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 1.177361e-01 | 0.929 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 7.974766e-02 | 1.098 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 6.720877e-02 | 1.173 |
| R-HSA-2151209 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation | 8.648406e-02 | 1.063 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 1.115717e-01 | 0.952 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 1.115717e-01 | 0.952 |
| R-HSA-5693606 | DNA Double Strand Break Response | 9.648961e-02 | 1.016 |
| R-HSA-6807070 | PTEN Regulation | 9.569479e-02 | 1.019 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 9.864816e-02 | 1.006 |
| R-HSA-171007 | p38MAPK events | 1.238582e-01 | 0.907 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 7.571968e-02 | 1.121 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 6.865011e-02 | 1.163 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 8.384115e-02 | 1.077 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 1.052044e-01 | 0.978 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 1.052044e-01 | 0.978 |
| R-HSA-111995 | phospho-PLA2 pathway | 7.367823e-02 | 1.133 |
| R-HSA-170984 | ARMS-mediated activation | 8.010323e-02 | 1.096 |
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 8.648406e-02 | 1.063 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 7.772532e-02 | 1.109 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 6.959298e-02 | 1.157 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 1.026922e-01 | 0.988 |
| R-HSA-983189 | Kinesins | 8.178637e-02 | 1.087 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 8.591167e-02 | 1.066 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 1.172734e-01 | 0.931 |
| R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 8.010323e-02 | 1.096 |
| R-HSA-9668250 | Defective factor IX causes hemophilia B | 8.648406e-02 | 1.063 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 9.911441e-02 | 1.004 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 1.053645e-01 | 0.977 |
| R-HSA-69166 | Removal of the Flap Intermediate | 1.177361e-01 | 0.929 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 1.118757e-01 | 0.951 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 1.089231e-01 | 0.963 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 8.010323e-02 | 1.096 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 1.115717e-01 | 0.952 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 1.177361e-01 | 0.929 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 1.238582e-01 | 0.907 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 1.141237e-01 | 0.943 |
| R-HSA-877300 | Interferon gamma signaling | 1.263749e-01 | 0.898 |
| R-HSA-9634635 | Estrogen-stimulated signaling through PRKCZ | 8.010323e-02 | 1.096 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 8.010323e-02 | 1.096 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 1.177361e-01 | 0.929 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 8.493141e-02 | 1.071 |
| R-HSA-9659379 | Sensory processing of sound | 1.232299e-01 | 0.909 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 1.177361e-01 | 0.929 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 1.238582e-01 | 0.907 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 9.864816e-02 | 1.006 |
| R-HSA-5653656 | Vesicle-mediated transport | 6.357661e-02 | 1.197 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 7.373108e-02 | 1.132 |
| R-HSA-73894 | DNA Repair | 1.263645e-01 | 0.898 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 8.799762e-02 | 1.056 |
| R-HSA-8848021 | Signaling by PTK6 | 8.799762e-02 | 1.056 |
| R-HSA-180786 | Extension of Telomeres | 7.974766e-02 | 1.098 |
| R-HSA-373755 | Semaphorin interactions | 8.799762e-02 | 1.056 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 7.525772e-02 | 1.123 |
| R-HSA-74751 | Insulin receptor signalling cascade | 9.009869e-02 | 1.045 |
| R-HSA-70326 | Glucose metabolism | 6.395843e-02 | 1.194 |
| R-HSA-3371556 | Cellular response to heat stress | 6.865011e-02 | 1.163 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 8.178637e-02 | 1.087 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 6.996606e-02 | 1.155 |
| R-HSA-1442490 | Collagen degradation | 8.384115e-02 | 1.077 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 8.591167e-02 | 1.066 |
| R-HSA-112315 | Transmission across Chemical Synapses | 9.190863e-02 | 1.037 |
| R-HSA-112316 | Neuronal System | 1.264563e-01 | 0.898 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 7.373108e-02 | 1.132 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 9.569479e-02 | 1.019 |
| R-HSA-5357801 | Programmed Cell Death | 7.270118e-02 | 1.138 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 6.628501e-02 | 1.179 |
| R-HSA-9006936 | Signaling by TGFB family members | 1.279161e-01 | 0.893 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 1.293912e-01 | 0.888 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 1.299381e-01 | 0.886 |
| R-HSA-176412 | Phosphorylation of the APC/C | 1.299381e-01 | 0.886 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 1.299381e-01 | 0.886 |
| R-HSA-9664420 | Killing mechanisms | 1.299381e-01 | 0.886 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 1.299381e-01 | 0.886 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 1.299381e-01 | 0.886 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 1.299381e-01 | 0.886 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 1.301721e-01 | 0.885 |
| R-HSA-109581 | Apoptosis | 1.310190e-01 | 0.883 |
| R-HSA-9734767 | Developmental Cell Lineages | 1.355718e-01 | 0.868 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 1.359763e-01 | 0.867 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 1.359763e-01 | 0.867 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 1.359763e-01 | 0.867 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 1.359763e-01 | 0.867 |
| R-HSA-975110 | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | 1.359763e-01 | 0.867 |
| R-HSA-9651496 | Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) | 1.359763e-01 | 0.867 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 1.359763e-01 | 0.867 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 1.372033e-01 | 0.863 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 1.395657e-01 | 0.855 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 1.395657e-01 | 0.855 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 1.403338e-01 | 0.853 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 1.419369e-01 | 0.848 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 1.419729e-01 | 0.848 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 1.419729e-01 | 0.848 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 1.419729e-01 | 0.848 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 1.419729e-01 | 0.848 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 1.419729e-01 | 0.848 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 1.443169e-01 | 0.841 |
| R-HSA-70268 | Pyruvate metabolism | 1.443169e-01 | 0.841 |
| R-HSA-438064 | Post NMDA receptor activation events | 1.443169e-01 | 0.841 |
| R-HSA-168249 | Innate Immune System | 1.448777e-01 | 0.839 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 1.479283e-01 | 0.830 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 1.479283e-01 | 0.830 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 1.479283e-01 | 0.830 |
| R-HSA-180292 | GAB1 signalosome | 1.479283e-01 | 0.830 |
| R-HSA-3928664 | Ephrin signaling | 1.479283e-01 | 0.830 |
| R-HSA-73884 | Base Excision Repair | 1.515065e-01 | 0.820 |
| R-HSA-112310 | Neurotransmitter release cycle | 1.515065e-01 | 0.820 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 1.534527e-01 | 0.814 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 1.538426e-01 | 0.813 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 1.538426e-01 | 0.813 |
| R-HSA-9671793 | Diseases of hemostasis | 1.538426e-01 | 0.813 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 1.538426e-01 | 0.813 |
| R-HSA-392517 | Rap1 signalling | 1.538426e-01 | 0.813 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 1.563389e-01 | 0.806 |
| R-HSA-381070 | IRE1alpha activates chaperones | 1.563389e-01 | 0.806 |
| R-HSA-391251 | Protein folding | 1.587662e-01 | 0.799 |
| R-HSA-74752 | Signaling by Insulin receptor | 1.587662e-01 | 0.799 |
| R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 1.597163e-01 | 0.797 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 1.597163e-01 | 0.797 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 1.597163e-01 | 0.797 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 1.597163e-01 | 0.797 |
| R-HSA-1474290 | Collagen formation | 1.636419e-01 | 0.786 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 1.655496e-01 | 0.781 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 1.655496e-01 | 0.781 |
| R-HSA-167044 | Signalling to RAS | 1.655496e-01 | 0.781 |
| R-HSA-210991 | Basigin interactions | 1.655496e-01 | 0.781 |
| R-HSA-69186 | Lagging Strand Synthesis | 1.655496e-01 | 0.781 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 1.655496e-01 | 0.781 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 1.710052e-01 | 0.767 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 1.713428e-01 | 0.766 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 1.713428e-01 | 0.766 |
| R-HSA-157579 | Telomere Maintenance | 1.734721e-01 | 0.761 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 1.734721e-01 | 0.761 |
| R-HSA-350054 | Notch-HLH transcription pathway | 1.770961e-01 | 0.752 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 1.809072e-01 | 0.743 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 1.828098e-01 | 0.738 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 1.828098e-01 | 0.738 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 1.828098e-01 | 0.738 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 1.828098e-01 | 0.738 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 1.833965e-01 | 0.737 |
| R-HSA-68877 | Mitotic Prometaphase | 1.839078e-01 | 0.735 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 1.884842e-01 | 0.725 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 1.884842e-01 | 0.725 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 1.908941e-01 | 0.719 |
| R-HSA-1296041 | Activation of G protein gated Potassium channels | 1.941195e-01 | 0.712 |
| R-HSA-997272 | Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | 1.941195e-01 | 0.712 |
| R-HSA-1296059 | G protein gated Potassium channels | 1.941195e-01 | 0.712 |
| R-HSA-9839394 | TGFBR3 expression | 1.941195e-01 | 0.712 |
| R-HSA-203927 | MicroRNA (miRNA) biogenesis | 1.941195e-01 | 0.712 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 1.941195e-01 | 0.712 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 1.941195e-01 | 0.712 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 1.941195e-01 | 0.712 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 1.961640e-01 | 0.707 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 1.997160e-01 | 0.700 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 1.997160e-01 | 0.700 |
| R-HSA-525793 | Myogenesis | 1.997160e-01 | 0.700 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 1.997160e-01 | 0.700 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 2.034787e-01 | 0.691 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 2.034787e-01 | 0.691 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 2.052741e-01 | 0.688 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 2.052741e-01 | 0.688 |
| R-HSA-264876 | Insulin processing | 2.052741e-01 | 0.688 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 2.060073e-01 | 0.686 |
| R-HSA-171319 | Telomere Extension By Telomerase | 2.107938e-01 | 0.676 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 2.136135e-01 | 0.670 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 2.136135e-01 | 0.670 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 2.162756e-01 | 0.665 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 2.162756e-01 | 0.665 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 2.217196e-01 | 0.654 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 2.217196e-01 | 0.654 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 2.217196e-01 | 0.654 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 2.217196e-01 | 0.654 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 2.217196e-01 | 0.654 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 2.217196e-01 | 0.654 |
| R-HSA-114452 | Activation of BH3-only proteins | 2.217196e-01 | 0.654 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 2.237964e-01 | 0.650 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 2.271262e-01 | 0.644 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 2.271262e-01 | 0.644 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 2.271262e-01 | 0.644 |
| R-HSA-5694530 | Cargo concentration in the ER | 2.271262e-01 | 0.644 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 2.289026e-01 | 0.640 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 2.289026e-01 | 0.640 |
| R-HSA-1296065 | Inwardly rectifying K+ channels | 2.324955e-01 | 0.634 |
| R-HSA-69190 | DNA strand elongation | 2.324955e-01 | 0.634 |
| R-HSA-5693538 | Homology Directed Repair | 2.340171e-01 | 0.631 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 2.378278e-01 | 0.624 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 2.378278e-01 | 0.624 |
| R-HSA-354192 | Integrin signaling | 2.378278e-01 | 0.624 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 2.378278e-01 | 0.624 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 2.378278e-01 | 0.624 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 2.378278e-01 | 0.624 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 2.378278e-01 | 0.624 |
| R-HSA-6798695 | Neutrophil degranulation | 2.400103e-01 | 0.620 |
| R-HSA-73886 | Chromosome Maintenance | 2.417016e-01 | 0.617 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 2.417016e-01 | 0.617 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 2.417016e-01 | 0.617 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 2.431235e-01 | 0.614 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 2.431235e-01 | 0.614 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 2.431235e-01 | 0.614 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 2.431235e-01 | 0.614 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 2.431235e-01 | 0.614 |
| R-HSA-2132295 | MHC class II antigen presentation | 2.468315e-01 | 0.608 |
| R-HSA-162906 | HIV Infection | 2.469345e-01 | 0.607 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 2.483826e-01 | 0.605 |
| R-HSA-180746 | Nuclear import of Rev protein | 2.483826e-01 | 0.605 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 2.483826e-01 | 0.605 |
| R-HSA-162909 | Host Interactions of HIV factors | 2.493981e-01 | 0.603 |
| R-HSA-381042 | PERK regulates gene expression | 2.536056e-01 | 0.596 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 2.536056e-01 | 0.596 |
| R-HSA-69206 | G1/S Transition | 2.545340e-01 | 0.594 |
| R-HSA-9845576 | Glycosphingolipid transport | 2.587925e-01 | 0.587 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 2.587925e-01 | 0.587 |
| R-HSA-114608 | Platelet degranulation | 2.596724e-01 | 0.586 |
| R-HSA-69481 | G2/M Checkpoints | 2.596724e-01 | 0.586 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 2.639438e-01 | 0.578 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 2.639438e-01 | 0.578 |
| R-HSA-8939211 | ESR-mediated signaling | 2.655667e-01 | 0.576 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 2.690596e-01 | 0.570 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 2.690596e-01 | 0.570 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 2.741401e-01 | 0.562 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 2.741401e-01 | 0.562 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 2.741401e-01 | 0.562 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 2.741401e-01 | 0.562 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 2.750929e-01 | 0.561 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 2.776625e-01 | 0.556 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 2.791856e-01 | 0.554 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 2.791856e-01 | 0.554 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 2.791856e-01 | 0.554 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 2.791856e-01 | 0.554 |
| R-HSA-5260271 | Diseases of Immune System | 2.791856e-01 | 0.554 |
| R-HSA-71240 | Tryptophan catabolism | 2.791856e-01 | 0.554 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 2.841964e-01 | 0.546 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 2.841964e-01 | 0.546 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 2.841964e-01 | 0.546 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 2.891726e-01 | 0.539 |
| R-HSA-449147 | Signaling by Interleukins | 2.940713e-01 | 0.532 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 2.941146e-01 | 0.531 |
| R-HSA-991365 | Activation of GABAB receptors | 2.941146e-01 | 0.531 |
| R-HSA-977444 | GABA B receptor activation | 2.941146e-01 | 0.531 |
| R-HSA-165159 | MTOR signalling | 2.941146e-01 | 0.531 |
| R-HSA-111996 | Ca-dependent events | 2.941146e-01 | 0.531 |
| R-HSA-168256 | Immune System | 2.955460e-01 | 0.529 |
| R-HSA-8854214 | TBC/RABGAPs | 2.990224e-01 | 0.524 |
| R-HSA-9907900 | Proteasome assembly | 3.038965e-01 | 0.517 |
| R-HSA-375280 | Amine ligand-binding receptors | 3.038965e-01 | 0.517 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 3.087370e-01 | 0.510 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 3.087370e-01 | 0.510 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 3.087370e-01 | 0.510 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 3.087370e-01 | 0.510 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 3.087370e-01 | 0.510 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 3.135441e-01 | 0.504 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 3.135441e-01 | 0.504 |
| R-HSA-9839373 | Signaling by TGFBR3 | 3.135441e-01 | 0.504 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 3.135441e-01 | 0.504 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 3.160871e-01 | 0.500 |
| R-HSA-416476 | G alpha (q) signalling events | 3.165671e-01 | 0.500 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 3.186361e-01 | 0.497 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 3.230592e-01 | 0.491 |
| R-HSA-9758941 | Gastrulation | 3.237275e-01 | 0.490 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 3.277676e-01 | 0.484 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 3.288096e-01 | 0.483 |
| R-HSA-446652 | Interleukin-1 family signaling | 3.313470e-01 | 0.480 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 3.389431e-01 | 0.470 |
| R-HSA-162587 | HIV Life Cycle | 3.439932e-01 | 0.463 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 3.462788e-01 | 0.461 |
| R-HSA-9711097 | Cellular response to starvation | 3.465137e-01 | 0.460 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 3.508272e-01 | 0.455 |
| R-HSA-5633007 | Regulation of TP53 Activity | 3.515455e-01 | 0.454 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 3.553441e-01 | 0.449 |
| R-HSA-9012852 | Signaling by NOTCH3 | 3.553441e-01 | 0.449 |
| R-HSA-193648 | NRAGE signals death through JNK | 3.598299e-01 | 0.444 |
| R-HSA-177929 | Signaling by EGFR | 3.598299e-01 | 0.444 |
| R-HSA-2467813 | Separation of Sister Chromatids | 3.615695e-01 | 0.442 |
| R-HSA-2408522 | Selenoamino acid metabolism | 3.615695e-01 | 0.442 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 3.642848e-01 | 0.439 |
| R-HSA-5619102 | SLC transporter disorders | 3.690507e-01 | 0.433 |
| R-HSA-191859 | snRNP Assembly | 3.731025e-01 | 0.428 |
| R-HSA-194441 | Metabolism of non-coding RNA | 3.731025e-01 | 0.428 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 3.731025e-01 | 0.428 |
| R-HSA-186712 | Regulation of beta-cell development | 3.731025e-01 | 0.428 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 3.774658e-01 | 0.423 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 3.774658e-01 | 0.423 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 3.774658e-01 | 0.423 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 3.774658e-01 | 0.423 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 3.774658e-01 | 0.423 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 3.774658e-01 | 0.423 |
| R-HSA-1227986 | Signaling by ERBB2 | 3.774658e-01 | 0.423 |
| R-HSA-8873719 | RAB geranylgeranylation | 3.774658e-01 | 0.423 |
| R-HSA-379724 | tRNA Aminoacylation | 3.774658e-01 | 0.423 |
| R-HSA-977443 | GABA receptor activation | 3.774658e-01 | 0.423 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 3.789728e-01 | 0.421 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 3.817990e-01 | 0.418 |
| R-HSA-112043 | PLC beta mediated events | 3.817990e-01 | 0.418 |
| R-HSA-6784531 | tRNA processing in the nucleus | 3.861024e-01 | 0.413 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 3.861024e-01 | 0.413 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 3.903760e-01 | 0.409 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 3.903760e-01 | 0.409 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 3.903760e-01 | 0.409 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 3.903760e-01 | 0.409 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 3.946201e-01 | 0.404 |
| R-HSA-382551 | Transport of small molecules | 3.964859e-01 | 0.402 |
| R-HSA-168255 | Influenza Infection | 4.010573e-01 | 0.397 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 4.030208e-01 | 0.395 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 4.071776e-01 | 0.390 |
| R-HSA-112040 | G-protein mediated events | 4.071776e-01 | 0.390 |
| R-HSA-5218859 | Regulated Necrosis | 4.113058e-01 | 0.386 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 4.113058e-01 | 0.386 |
| R-HSA-74160 | Gene expression (Transcription) | 4.114012e-01 | 0.386 |
| R-HSA-212436 | Generic Transcription Pathway | 4.131592e-01 | 0.384 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 4.220813e-01 | 0.375 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 4.227744e-01 | 0.374 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 4.235203e-01 | 0.373 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 4.235203e-01 | 0.373 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 4.235203e-01 | 0.373 |
| R-HSA-1643685 | Disease | 4.259569e-01 | 0.371 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 4.275356e-01 | 0.369 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 4.275356e-01 | 0.369 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 4.275356e-01 | 0.369 |
| R-HSA-5617833 | Cilium Assembly | 4.275468e-01 | 0.369 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 4.315233e-01 | 0.365 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 4.315233e-01 | 0.365 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 4.315233e-01 | 0.365 |
| R-HSA-4086398 | Ca2+ pathway | 4.315233e-01 | 0.365 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 4.385885e-01 | 0.358 |
| R-HSA-380287 | Centrosome maturation | 4.394162e-01 | 0.357 |
| R-HSA-1980143 | Signaling by NOTCH1 | 4.433219e-01 | 0.353 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 4.433219e-01 | 0.353 |
| R-HSA-5689603 | UCH proteinases | 4.433219e-01 | 0.353 |
| R-HSA-73864 | RNA Polymerase I Transcription | 4.510524e-01 | 0.346 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 4.557417e-01 | 0.341 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 4.586766e-01 | 0.338 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 4.590199e-01 | 0.338 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 4.624492e-01 | 0.335 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 4.661958e-01 | 0.331 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 4.736114e-01 | 0.325 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 4.736114e-01 | 0.325 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 4.845439e-01 | 0.315 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 4.845439e-01 | 0.315 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 4.917069e-01 | 0.308 |
| R-HSA-156902 | Peptide chain elongation | 4.917069e-01 | 0.308 |
| R-HSA-1236974 | ER-Phagosome pathway | 4.952513e-01 | 0.305 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 4.987712e-01 | 0.302 |
| R-HSA-8951664 | Neddylation | 5.009288e-01 | 0.300 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 5.022668e-01 | 0.299 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 5.091857e-01 | 0.293 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 5.160092e-01 | 0.287 |
| R-HSA-9837999 | Mitochondrial protein degradation | 5.160092e-01 | 0.287 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 5.161757e-01 | 0.287 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 5.193856e-01 | 0.285 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 5.227387e-01 | 0.282 |
| R-HSA-72764 | Eukaryotic Translation Termination | 5.227387e-01 | 0.282 |
| R-HSA-72312 | rRNA processing | 5.247508e-01 | 0.280 |
| R-HSA-1296071 | Potassium Channels | 5.260686e-01 | 0.279 |
| R-HSA-3247509 | Chromatin modifying enzymes | 5.290004e-01 | 0.277 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 5.293755e-01 | 0.276 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 5.326595e-01 | 0.274 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 5.359207e-01 | 0.271 |
| R-HSA-3214847 | HATs acetylate histones | 5.359207e-01 | 0.271 |
| R-HSA-73857 | RNA Polymerase II Transcription | 5.362236e-01 | 0.271 |
| R-HSA-382556 | ABC-family proteins mediated transport | 5.391595e-01 | 0.268 |
| R-HSA-2408557 | Selenocysteine synthesis | 5.423758e-01 | 0.266 |
| R-HSA-9020702 | Interleukin-1 signaling | 5.423758e-01 | 0.266 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 5.455699e-01 | 0.263 |
| R-HSA-192823 | Viral mRNA Translation | 5.487418e-01 | 0.261 |
| R-HSA-8953854 | Metabolism of RNA | 5.510785e-01 | 0.259 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 5.518919e-01 | 0.258 |
| R-HSA-111885 | Opioid Signalling | 5.518919e-01 | 0.258 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 5.559978e-01 | 0.255 |
| R-HSA-5696398 | Nucleotide Excision Repair | 5.581267e-01 | 0.253 |
| R-HSA-4839726 | Chromatin organization | 5.600542e-01 | 0.252 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 5.612118e-01 | 0.251 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 5.642755e-01 | 0.249 |
| R-HSA-69239 | Synthesis of DNA | 5.642755e-01 | 0.249 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 5.673181e-01 | 0.246 |
| R-HSA-5688426 | Deubiquitination | 5.720662e-01 | 0.243 |
| R-HSA-1483249 | Inositol phosphate metabolism | 5.792792e-01 | 0.237 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 5.851362e-01 | 0.233 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 5.851362e-01 | 0.233 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 5.880344e-01 | 0.231 |
| R-HSA-9711123 | Cellular response to chemical stress | 5.972801e-01 | 0.224 |
| R-HSA-9007101 | Rab regulation of trafficking | 5.994277e-01 | 0.222 |
| R-HSA-1592230 | Mitochondrial biogenesis | 5.994277e-01 | 0.222 |
| R-HSA-2980736 | Peptide hormone metabolism | 5.994277e-01 | 0.222 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 6.022268e-01 | 0.220 |
| R-HSA-72766 | Translation | 6.086957e-01 | 0.216 |
| R-HSA-6809371 | Formation of the cornified envelope | 6.186194e-01 | 0.209 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 6.466490e-01 | 0.189 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 6.567297e-01 | 0.183 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 6.567297e-01 | 0.183 |
| R-HSA-9948299 | Ribosome-associated quality control | 6.615172e-01 | 0.179 |
| R-HSA-1632852 | Macroautophagy | 6.685746e-01 | 0.175 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 6.731983e-01 | 0.172 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 6.731983e-01 | 0.172 |
| R-HSA-69242 | S Phase | 6.866892e-01 | 0.163 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 6.953750e-01 | 0.158 |
| R-HSA-69306 | DNA Replication | 6.975089e-01 | 0.156 |
| R-HSA-73887 | Death Receptor Signaling | 6.996280e-01 | 0.155 |
| R-HSA-9612973 | Autophagy | 7.038222e-01 | 0.153 |
| R-HSA-9610379 | HCMV Late Events | 7.058974e-01 | 0.151 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 7.184054e-01 | 0.144 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 7.296469e-01 | 0.137 |
| R-HSA-392499 | Metabolism of proteins | 7.306902e-01 | 0.136 |
| R-HSA-72306 | tRNA processing | 7.334818e-01 | 0.135 |
| R-HSA-418555 | G alpha (s) signalling events | 7.353510e-01 | 0.134 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 7.353510e-01 | 0.134 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 7.372072e-01 | 0.132 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 7.426987e-01 | 0.129 |
| R-HSA-597592 | Post-translational protein modification | 7.429612e-01 | 0.129 |
| R-HSA-3781865 | Diseases of glycosylation | 7.585000e-01 | 0.120 |
| R-HSA-1280218 | Adaptive Immune System | 7.591359e-01 | 0.120 |
| R-HSA-69275 | G2/M Transition | 7.618786e-01 | 0.118 |
| R-HSA-375276 | Peptide ligand-binding receptors | 7.618786e-01 | 0.118 |
| R-HSA-5663205 | Infectious disease | 7.640323e-01 | 0.117 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 7.652104e-01 | 0.116 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 7.744814e-01 | 0.111 |
| R-HSA-9609690 | HCMV Early Events | 7.780817e-01 | 0.109 |
| R-HSA-9824439 | Bacterial Infection Pathways | 7.826376e-01 | 0.106 |
| R-HSA-389948 | Co-inhibition by PD-1 | 7.842526e-01 | 0.106 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 7.871824e-01 | 0.104 |
| R-HSA-376176 | Signaling by ROBO receptors | 7.887689e-01 | 0.103 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 7.887689e-01 | 0.103 |
| R-HSA-6805567 | Keratinization | 7.946451e-01 | 0.100 |
| R-HSA-388396 | GPCR downstream signalling | 8.087284e-01 | 0.092 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 8.167357e-01 | 0.088 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 8.216824e-01 | 0.085 |
| R-HSA-15869 | Metabolism of nucleotides | 8.338464e-01 | 0.079 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 8.350166e-01 | 0.078 |
| R-HSA-9609646 | HCMV Infection | 8.495061e-01 | 0.071 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 8.557610e-01 | 0.068 |
| R-HSA-372790 | Signaling by GPCR | 8.653404e-01 | 0.063 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 8.774409e-01 | 0.057 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 8.800193e-01 | 0.056 |
| R-HSA-1483257 | Phospholipid metabolism | 8.905851e-01 | 0.050 |
| R-HSA-195721 | Signaling by WNT | 8.928893e-01 | 0.049 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 9.103119e-01 | 0.041 |
| R-HSA-9679506 | SARS-CoV Infections | 9.128115e-01 | 0.040 |
| R-HSA-500792 | GPCR ligand binding | 9.284197e-01 | 0.032 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.474339e-01 | 0.023 |
| R-HSA-418594 | G alpha (i) signalling events | 9.510577e-01 | 0.022 |
| R-HSA-5668914 | Diseases of metabolism | 9.575788e-01 | 0.019 |
| R-HSA-9824446 | Viral Infection Pathways | 9.622734e-01 | 0.017 |
| R-HSA-9709957 | Sensory Perception | 9.988406e-01 | 0.001 |
| R-HSA-1430728 | Metabolism | 9.999806e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.999836e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
ERK5 |
0.806 | 0.340 | 1 | 0.818 |
NLK |
0.798 | 0.264 | 1 | 0.777 |
CDKL5 |
0.793 | 0.143 | -3 | 0.759 |
HIPK4 |
0.792 | 0.149 | 1 | 0.785 |
CLK3 |
0.792 | 0.142 | 1 | 0.813 |
CDKL1 |
0.791 | 0.132 | -3 | 0.776 |
P38A |
0.789 | 0.241 | 1 | 0.774 |
CDK18 |
0.789 | 0.232 | 1 | 0.693 |
KIS |
0.788 | 0.183 | 1 | 0.756 |
DYRK2 |
0.788 | 0.194 | 1 | 0.773 |
HIPK1 |
0.788 | 0.207 | 1 | 0.767 |
P38B |
0.787 | 0.232 | 1 | 0.748 |
ICK |
0.786 | 0.127 | -3 | 0.794 |
ERK1 |
0.786 | 0.213 | 1 | 0.729 |
COT |
0.785 | 0.044 | 2 | 0.848 |
CDK8 |
0.785 | 0.179 | 1 | 0.737 |
HIPK2 |
0.784 | 0.193 | 1 | 0.713 |
CDK17 |
0.784 | 0.221 | 1 | 0.662 |
CDK14 |
0.784 | 0.247 | 1 | 0.702 |
MTOR |
0.784 | 0.140 | 1 | 0.689 |
CDK19 |
0.784 | 0.193 | 1 | 0.712 |
CDK5 |
0.784 | 0.221 | 1 | 0.746 |
ERK2 |
0.784 | 0.222 | 1 | 0.738 |
JNK2 |
0.783 | 0.243 | 1 | 0.700 |
CDK7 |
0.783 | 0.177 | 1 | 0.737 |
RSK2 |
0.782 | 0.096 | -3 | 0.758 |
CDC7 |
0.782 | 0.050 | 1 | 0.690 |
P90RSK |
0.781 | 0.098 | -3 | 0.741 |
CLK4 |
0.780 | 0.133 | -3 | 0.752 |
CLK1 |
0.780 | 0.140 | -3 | 0.737 |
PRPK |
0.780 | -0.023 | -1 | 0.659 |
HIPK3 |
0.780 | 0.184 | 1 | 0.747 |
CAMK1B |
0.779 | 0.031 | -3 | 0.826 |
DYRK1A |
0.779 | 0.163 | 1 | 0.770 |
PKCD |
0.779 | 0.109 | 2 | 0.853 |
NIM1 |
0.779 | 0.184 | 3 | 0.735 |
PIM3 |
0.778 | 0.015 | -3 | 0.809 |
PRKD2 |
0.778 | 0.091 | -3 | 0.728 |
CDK13 |
0.778 | 0.180 | 1 | 0.718 |
MOS |
0.777 | -0.019 | 1 | 0.713 |
DYRK1B |
0.777 | 0.185 | 1 | 0.719 |
P38D |
0.777 | 0.240 | 1 | 0.679 |
ATR |
0.776 | 0.004 | 1 | 0.694 |
PRKD1 |
0.776 | 0.081 | -3 | 0.748 |
P38G |
0.776 | 0.204 | 1 | 0.661 |
CAMLCK |
0.776 | 0.032 | -2 | 0.534 |
PKN3 |
0.776 | 0.035 | -3 | 0.777 |
DYRK3 |
0.776 | 0.166 | 1 | 0.765 |
DAPK2 |
0.776 | 0.046 | -3 | 0.813 |
RSK3 |
0.776 | 0.079 | -3 | 0.747 |
NIK |
0.775 | 0.038 | -3 | 0.826 |
SRPK1 |
0.775 | 0.088 | -3 | 0.738 |
CDK1 |
0.775 | 0.185 | 1 | 0.716 |
JNK3 |
0.775 | 0.217 | 1 | 0.733 |
MAK |
0.774 | 0.188 | -2 | 0.498 |
CDK12 |
0.774 | 0.178 | 1 | 0.704 |
CDK16 |
0.774 | 0.228 | 1 | 0.668 |
SKMLCK |
0.773 | 0.015 | -2 | 0.510 |
MST4 |
0.773 | 0.093 | 2 | 0.841 |
CDK10 |
0.773 | 0.212 | 1 | 0.698 |
NDR2 |
0.772 | 0.025 | -3 | 0.804 |
PRKD3 |
0.772 | 0.079 | -3 | 0.724 |
NUAK2 |
0.772 | 0.038 | -3 | 0.806 |
PKN2 |
0.772 | 0.046 | -3 | 0.793 |
PKACG |
0.772 | 0.030 | -2 | 0.474 |
PIM1 |
0.771 | 0.041 | -3 | 0.769 |
CDK3 |
0.771 | 0.195 | 1 | 0.676 |
MOK |
0.771 | 0.199 | 1 | 0.782 |
WNK1 |
0.771 | -0.019 | -2 | 0.511 |
MARK4 |
0.771 | 0.062 | 4 | 0.791 |
NDR1 |
0.771 | 0.021 | -3 | 0.797 |
P70S6KB |
0.770 | 0.038 | -3 | 0.770 |
RSK4 |
0.770 | 0.086 | -3 | 0.736 |
AMPKA1 |
0.770 | 0.029 | -3 | 0.798 |
CDK9 |
0.770 | 0.163 | 1 | 0.724 |
RAF1 |
0.770 | -0.088 | 1 | 0.648 |
CDK2 |
0.770 | 0.159 | 1 | 0.746 |
DYRK4 |
0.769 | 0.175 | 1 | 0.729 |
AURC |
0.769 | 0.036 | -2 | 0.460 |
SRPK2 |
0.769 | 0.078 | -3 | 0.675 |
BMPR2 |
0.768 | -0.195 | -2 | 0.487 |
PKCA |
0.768 | 0.103 | 2 | 0.817 |
PDHK4 |
0.768 | -0.125 | 1 | 0.683 |
QIK |
0.768 | 0.069 | -3 | 0.776 |
SGK3 |
0.768 | 0.077 | -3 | 0.733 |
MAPKAPK3 |
0.768 | 0.025 | -3 | 0.722 |
PAK6 |
0.767 | 0.050 | -2 | 0.518 |
TGFBR2 |
0.767 | -0.088 | -2 | 0.412 |
GCN2 |
0.767 | -0.114 | 2 | 0.801 |
AURB |
0.767 | 0.028 | -2 | 0.455 |
PKG2 |
0.767 | 0.029 | -2 | 0.461 |
TSSK2 |
0.767 | 0.007 | -5 | 0.835 |
GRK1 |
0.767 | -0.010 | -2 | 0.489 |
MNK2 |
0.766 | 0.038 | -2 | 0.489 |
ULK2 |
0.766 | -0.087 | 2 | 0.835 |
AMPKA2 |
0.766 | 0.033 | -3 | 0.779 |
RIPK3 |
0.766 | -0.044 | 3 | 0.726 |
AKT2 |
0.766 | 0.079 | -3 | 0.689 |
AKT1 |
0.766 | 0.104 | -3 | 0.696 |
TBK1 |
0.766 | -0.106 | 1 | 0.541 |
PDHK1 |
0.766 | -0.109 | 1 | 0.665 |
PKACB |
0.765 | 0.068 | -2 | 0.444 |
IKKB |
0.765 | -0.089 | -2 | 0.476 |
TSSK1 |
0.765 | 0.022 | -3 | 0.810 |
CLK2 |
0.765 | 0.142 | -3 | 0.747 |
QSK |
0.765 | 0.076 | 4 | 0.762 |
CAMK4 |
0.765 | -0.016 | -3 | 0.783 |
DSTYK |
0.765 | -0.049 | 2 | 0.857 |
MLK1 |
0.764 | -0.065 | 2 | 0.853 |
SRPK3 |
0.764 | 0.059 | -3 | 0.724 |
SIK |
0.764 | 0.079 | -3 | 0.738 |
PKCB |
0.764 | 0.074 | 2 | 0.821 |
CHAK2 |
0.764 | -0.066 | -1 | 0.613 |
PKCG |
0.764 | 0.071 | 2 | 0.811 |
GRK6 |
0.764 | 0.027 | 1 | 0.673 |
MSK2 |
0.764 | 0.028 | -3 | 0.714 |
GRK5 |
0.764 | -0.115 | -3 | 0.821 |
MELK |
0.763 | 0.011 | -3 | 0.755 |
NUAK1 |
0.763 | 0.023 | -3 | 0.765 |
CAMK2G |
0.763 | -0.090 | 2 | 0.761 |
CDK4 |
0.763 | 0.193 | 1 | 0.694 |
PAK3 |
0.763 | -0.018 | -2 | 0.503 |
WNK3 |
0.763 | -0.132 | 1 | 0.637 |
PKR |
0.763 | 0.047 | 1 | 0.677 |
LATS1 |
0.763 | 0.025 | -3 | 0.817 |
MNK1 |
0.762 | 0.042 | -2 | 0.502 |
IRE1 |
0.762 | -0.030 | 1 | 0.646 |
MPSK1 |
0.762 | 0.105 | 1 | 0.637 |
RIPK1 |
0.762 | -0.062 | 1 | 0.643 |
PAK1 |
0.762 | -0.005 | -2 | 0.503 |
PKCH |
0.762 | 0.041 | 2 | 0.822 |
LATS2 |
0.761 | -0.013 | -5 | 0.767 |
CAMK2D |
0.761 | -0.021 | -3 | 0.768 |
MYLK4 |
0.761 | 0.012 | -2 | 0.499 |
PKCZ |
0.761 | 0.019 | 2 | 0.833 |
MASTL |
0.760 | -0.113 | -2 | 0.446 |
MAPKAPK2 |
0.760 | 0.035 | -3 | 0.711 |
IKKE |
0.760 | -0.106 | 1 | 0.536 |
PKACA |
0.760 | 0.061 | -2 | 0.430 |
CDK6 |
0.760 | 0.183 | 1 | 0.691 |
MSK1 |
0.759 | 0.033 | -3 | 0.721 |
PIM2 |
0.759 | 0.038 | -3 | 0.730 |
MLK2 |
0.758 | -0.083 | 2 | 0.850 |
PKCT |
0.758 | 0.069 | 2 | 0.833 |
PRKX |
0.758 | 0.063 | -3 | 0.690 |
PAK2 |
0.757 | -0.026 | -2 | 0.502 |
PHKG1 |
0.757 | -0.009 | -3 | 0.776 |
NEK9 |
0.757 | -0.060 | 2 | 0.862 |
HUNK |
0.756 | -0.112 | 2 | 0.788 |
CHK1 |
0.756 | 0.031 | -3 | 0.773 |
IRE2 |
0.756 | -0.042 | 2 | 0.834 |
MLK3 |
0.756 | -0.016 | 2 | 0.812 |
SMMLCK |
0.756 | 0.029 | -3 | 0.784 |
IKKA |
0.756 | -0.038 | -2 | 0.453 |
VRK2 |
0.756 | -0.046 | 1 | 0.728 |
DLK |
0.756 | -0.126 | 1 | 0.669 |
MARK2 |
0.756 | 0.036 | 4 | 0.708 |
GRK7 |
0.755 | 0.006 | 1 | 0.638 |
JNK1 |
0.755 | 0.196 | 1 | 0.692 |
ULK1 |
0.755 | -0.132 | -3 | 0.695 |
BCKDK |
0.755 | -0.099 | -1 | 0.620 |
SMG1 |
0.755 | -0.024 | 1 | 0.650 |
ANKRD3 |
0.755 | -0.151 | 1 | 0.679 |
BMPR1B |
0.755 | -0.019 | 1 | 0.664 |
ALK4 |
0.755 | -0.080 | -2 | 0.456 |
PRP4 |
0.755 | 0.047 | -3 | 0.608 |
NEK6 |
0.754 | -0.113 | -2 | 0.438 |
ATM |
0.754 | -0.043 | 1 | 0.647 |
BUB1 |
0.754 | 0.129 | -5 | 0.864 |
IRAK4 |
0.754 | 0.005 | 1 | 0.640 |
NEK7 |
0.754 | -0.166 | -3 | 0.727 |
MEK1 |
0.753 | -0.075 | 2 | 0.815 |
PHKG2 |
0.753 | 0.037 | -3 | 0.774 |
PKCI |
0.753 | 0.050 | 2 | 0.802 |
DCAMKL1 |
0.753 | 0.037 | -3 | 0.755 |
MARK3 |
0.753 | 0.032 | 4 | 0.728 |
CAMK1G |
0.752 | 0.006 | -3 | 0.739 |
TTBK2 |
0.752 | -0.122 | 2 | 0.722 |
PKCE |
0.752 | 0.085 | 2 | 0.801 |
TGFBR1 |
0.752 | -0.057 | -2 | 0.424 |
AURA |
0.752 | 0.004 | -2 | 0.439 |
AKT3 |
0.751 | 0.080 | -3 | 0.629 |
ERK7 |
0.751 | 0.075 | 2 | 0.540 |
DNAPK |
0.751 | 0.022 | 1 | 0.585 |
WNK4 |
0.751 | -0.044 | -2 | 0.503 |
P70S6K |
0.750 | 0.030 | -3 | 0.688 |
PERK |
0.750 | -0.098 | -2 | 0.469 |
MARK1 |
0.750 | 0.020 | 4 | 0.745 |
CHAK1 |
0.749 | -0.104 | 2 | 0.814 |
SGK1 |
0.748 | 0.073 | -3 | 0.621 |
MEK5 |
0.748 | -0.083 | 2 | 0.846 |
CAMK1D |
0.748 | 0.029 | -3 | 0.672 |
PKN1 |
0.748 | 0.051 | -3 | 0.696 |
BRSK2 |
0.748 | -0.032 | -3 | 0.758 |
DCAMKL2 |
0.748 | 0.014 | -3 | 0.777 |
GRK2 |
0.747 | -0.069 | -2 | 0.408 |
BRAF |
0.747 | -0.040 | -4 | 0.789 |
MST3 |
0.747 | 0.049 | 2 | 0.836 |
GRK4 |
0.747 | -0.154 | -2 | 0.443 |
CAMK2B |
0.747 | -0.037 | 2 | 0.702 |
PINK1 |
0.747 | -0.052 | 1 | 0.730 |
MEKK1 |
0.747 | -0.030 | 1 | 0.631 |
CAMK1A |
0.747 | 0.050 | -3 | 0.665 |
MLK4 |
0.747 | -0.076 | 2 | 0.780 |
MRCKB |
0.747 | 0.051 | -3 | 0.724 |
NEK2 |
0.746 | -0.084 | 2 | 0.843 |
ZAK |
0.746 | -0.041 | 1 | 0.623 |
PAK5 |
0.746 | -0.000 | -2 | 0.447 |
YSK4 |
0.746 | -0.122 | 1 | 0.587 |
ALK2 |
0.746 | -0.067 | -2 | 0.452 |
ACVR2A |
0.746 | -0.094 | -2 | 0.401 |
DAPK3 |
0.746 | 0.030 | -3 | 0.777 |
TAO3 |
0.746 | 0.032 | 1 | 0.628 |
PLK4 |
0.746 | -0.031 | 2 | 0.695 |
MEKK2 |
0.745 | -0.029 | 2 | 0.842 |
SBK |
0.745 | 0.088 | -3 | 0.589 |
CHK2 |
0.745 | 0.048 | -3 | 0.640 |
CAMK2A |
0.745 | -0.039 | 2 | 0.714 |
BRSK1 |
0.744 | -0.031 | -3 | 0.754 |
MAP3K15 |
0.744 | 0.091 | 1 | 0.611 |
PLK1 |
0.744 | -0.150 | -2 | 0.406 |
ACVR2B |
0.744 | -0.093 | -2 | 0.412 |
PDK1 |
0.743 | 0.026 | 1 | 0.660 |
SNRK |
0.743 | -0.095 | 2 | 0.771 |
CK1E |
0.743 | -0.007 | -3 | 0.572 |
MRCKA |
0.743 | 0.043 | -3 | 0.737 |
CAMKK2 |
0.743 | 0.120 | -2 | 0.586 |
CAMKK1 |
0.743 | 0.115 | -2 | 0.584 |
DRAK1 |
0.743 | -0.067 | 1 | 0.615 |
MEKK3 |
0.743 | -0.095 | 1 | 0.628 |
ROCK2 |
0.742 | 0.051 | -3 | 0.753 |
TAO2 |
0.742 | 0.014 | 2 | 0.887 |
DMPK1 |
0.742 | 0.077 | -3 | 0.762 |
SSTK |
0.742 | -0.053 | 4 | 0.770 |
FAM20C |
0.741 | -0.002 | 2 | 0.535 |
NEK5 |
0.741 | -0.050 | 1 | 0.657 |
MAPKAPK5 |
0.740 | -0.045 | -3 | 0.661 |
DAPK1 |
0.740 | 0.018 | -3 | 0.762 |
GSK3B |
0.740 | 0.018 | 4 | 0.472 |
GSK3A |
0.740 | 0.047 | 4 | 0.483 |
BMPR1A |
0.740 | -0.039 | 1 | 0.647 |
MEKK6 |
0.739 | 0.046 | 1 | 0.640 |
HRI |
0.739 | -0.177 | -2 | 0.443 |
PAK4 |
0.738 | -0.005 | -2 | 0.449 |
NEK11 |
0.738 | -0.028 | 1 | 0.622 |
NEK8 |
0.738 | -0.059 | 2 | 0.865 |
EEF2K |
0.738 | 0.007 | 3 | 0.789 |
GAK |
0.738 | -0.032 | 1 | 0.649 |
LRRK2 |
0.737 | -0.004 | 2 | 0.862 |
IRAK1 |
0.737 | -0.083 | -1 | 0.550 |
TTBK1 |
0.737 | -0.070 | 2 | 0.650 |
TLK2 |
0.736 | -0.166 | 1 | 0.648 |
LKB1 |
0.736 | 0.067 | -3 | 0.689 |
PASK |
0.735 | -0.045 | -3 | 0.818 |
NEK4 |
0.735 | 0.029 | 1 | 0.598 |
HGK |
0.735 | 0.019 | 3 | 0.833 |
CK1D |
0.734 | -0.010 | -3 | 0.524 |
PLK3 |
0.734 | -0.120 | 2 | 0.733 |
PKG1 |
0.734 | -0.001 | -2 | 0.410 |
GRK3 |
0.734 | -0.069 | -2 | 0.380 |
TAK1 |
0.733 | -0.057 | 1 | 0.655 |
NEK1 |
0.733 | 0.079 | 1 | 0.619 |
CK1A2 |
0.733 | -0.010 | -3 | 0.529 |
CK1G1 |
0.732 | -0.012 | -3 | 0.590 |
ROCK1 |
0.732 | 0.041 | -3 | 0.727 |
MINK |
0.731 | -0.000 | 1 | 0.600 |
TNIK |
0.731 | 0.022 | 3 | 0.828 |
GCK |
0.731 | -0.013 | 1 | 0.607 |
LOK |
0.731 | -0.047 | -2 | 0.451 |
MST2 |
0.730 | -0.052 | 1 | 0.615 |
YSK1 |
0.730 | 0.037 | 2 | 0.847 |
HPK1 |
0.730 | 0.004 | 1 | 0.587 |
CRIK |
0.729 | 0.045 | -3 | 0.695 |
KHS2 |
0.729 | 0.047 | 1 | 0.599 |
TLK1 |
0.728 | -0.202 | -2 | 0.400 |
PBK |
0.728 | -0.008 | 1 | 0.585 |
KHS1 |
0.728 | 0.023 | 1 | 0.590 |
RIPK2 |
0.726 | -0.104 | 1 | 0.575 |
VRK1 |
0.724 | -0.139 | 2 | 0.848 |
MST1 |
0.723 | -0.061 | 1 | 0.600 |
NEK3 |
0.723 | -0.005 | 1 | 0.606 |
MEK2 |
0.723 | -0.104 | 2 | 0.824 |
PDHK3_TYR |
0.723 | 0.122 | 4 | 0.859 |
HASPIN |
0.722 | -0.032 | -1 | 0.515 |
SLK |
0.721 | -0.103 | -2 | 0.400 |
TTK |
0.719 | -0.064 | -2 | 0.400 |
PLK2 |
0.718 | -0.028 | -3 | 0.783 |
ASK1 |
0.718 | -0.003 | 1 | 0.599 |
MYO3B |
0.717 | 0.021 | 2 | 0.854 |
PKMYT1_TYR |
0.717 | 0.118 | 3 | 0.828 |
TAO1 |
0.717 | -0.011 | 1 | 0.560 |
LIMK2_TYR |
0.716 | 0.064 | -3 | 0.800 |
TESK1_TYR |
0.715 | -0.005 | 3 | 0.847 |
STK33 |
0.715 | -0.120 | 2 | 0.640 |
BIKE |
0.715 | -0.028 | 1 | 0.532 |
CK2A2 |
0.715 | -0.051 | 1 | 0.556 |
MYO3A |
0.713 | -0.001 | 1 | 0.594 |
MAP2K4_TYR |
0.713 | 0.031 | -1 | 0.682 |
MAP2K7_TYR |
0.712 | -0.038 | 2 | 0.856 |
PINK1_TYR |
0.711 | -0.032 | 1 | 0.688 |
PDHK4_TYR |
0.711 | 0.010 | 2 | 0.837 |
ALPHAK3 |
0.710 | -0.040 | -1 | 0.545 |
TYK2 |
0.709 | 0.017 | 1 | 0.646 |
LIMK1_TYR |
0.708 | -0.015 | 2 | 0.880 |
BMPR2_TYR |
0.707 | -0.020 | -1 | 0.636 |
OSR1 |
0.706 | -0.117 | 2 | 0.806 |
JAK2 |
0.706 | 0.008 | 1 | 0.657 |
AAK1 |
0.706 | 0.009 | 1 | 0.456 |
MAP2K6_TYR |
0.706 | -0.065 | -1 | 0.658 |
EPHA6 |
0.705 | -0.019 | -1 | 0.576 |
ROS1 |
0.705 | -0.021 | 3 | 0.779 |
CK2A1 |
0.705 | -0.060 | 1 | 0.532 |
TYRO3 |
0.705 | -0.054 | 3 | 0.810 |
TNNI3K_TYR |
0.704 | 0.048 | 1 | 0.699 |
YANK3 |
0.704 | -0.034 | 2 | 0.369 |
MST1R |
0.701 | -0.075 | 3 | 0.828 |
JAK1 |
0.701 | 0.052 | 1 | 0.592 |
RET |
0.701 | -0.128 | 1 | 0.652 |
PDHK1_TYR |
0.700 | -0.157 | -1 | 0.636 |
EPHB4 |
0.700 | -0.061 | -1 | 0.575 |
CSF1R |
0.700 | -0.054 | 3 | 0.806 |
DDR1 |
0.699 | -0.088 | 4 | 0.809 |
TNK2 |
0.699 | -0.015 | 3 | 0.798 |
ABL2 |
0.699 | -0.019 | -1 | 0.566 |
TNK1 |
0.699 | -0.027 | 3 | 0.774 |
ABL1 |
0.698 | -0.005 | -1 | 0.568 |
WEE1_TYR |
0.694 | -0.046 | -1 | 0.556 |
FER |
0.694 | -0.097 | 1 | 0.705 |
PDGFRB |
0.693 | -0.091 | 3 | 0.823 |
AXL |
0.693 | -0.076 | 3 | 0.796 |
YES1 |
0.692 | -0.089 | -1 | 0.627 |
JAK3 |
0.692 | -0.111 | 1 | 0.648 |
TXK |
0.692 | -0.058 | 1 | 0.660 |
TEK |
0.692 | -0.073 | 3 | 0.745 |
FLT3 |
0.691 | -0.092 | 3 | 0.801 |
FGR |
0.690 | -0.117 | 1 | 0.669 |
HCK |
0.690 | -0.077 | -1 | 0.590 |
MERTK |
0.690 | -0.066 | 3 | 0.775 |
PDGFRA |
0.690 | -0.093 | 3 | 0.821 |
CK1A |
0.690 | -0.046 | -3 | 0.454 |
NEK10_TYR |
0.689 | -0.056 | 1 | 0.521 |
FGFR1 |
0.689 | -0.089 | 3 | 0.789 |
LTK |
0.689 | -0.047 | 3 | 0.770 |
KDR |
0.689 | -0.091 | 3 | 0.766 |
ALK |
0.689 | -0.061 | 3 | 0.760 |
EPHA4 |
0.689 | -0.062 | 2 | 0.707 |
SRMS |
0.688 | -0.093 | 1 | 0.682 |
EPHB1 |
0.688 | -0.093 | 1 | 0.692 |
BTK |
0.688 | -0.078 | -1 | 0.565 |
EPHB3 |
0.688 | -0.087 | -1 | 0.556 |
FGFR2 |
0.688 | -0.126 | 3 | 0.789 |
TEC |
0.688 | -0.067 | -1 | 0.551 |
KIT |
0.688 | -0.110 | 3 | 0.809 |
STLK3 |
0.688 | -0.184 | 1 | 0.576 |
INSRR |
0.687 | -0.131 | 3 | 0.750 |
LCK |
0.687 | -0.074 | -1 | 0.578 |
DDR2 |
0.687 | -0.022 | 3 | 0.765 |
ITK |
0.686 | -0.087 | -1 | 0.572 |
EPHA1 |
0.686 | -0.063 | 3 | 0.800 |
EPHB2 |
0.683 | -0.106 | -1 | 0.542 |
BLK |
0.683 | -0.066 | -1 | 0.584 |
MET |
0.683 | -0.112 | 3 | 0.812 |
FRK |
0.683 | -0.071 | -1 | 0.578 |
BMX |
0.683 | -0.086 | -1 | 0.514 |
PTK2B |
0.682 | -0.034 | -1 | 0.562 |
PTK6 |
0.681 | -0.152 | -1 | 0.519 |
EPHA7 |
0.681 | -0.077 | 2 | 0.741 |
NTRK2 |
0.680 | -0.108 | 3 | 0.770 |
NTRK1 |
0.680 | -0.125 | -1 | 0.572 |
EPHA3 |
0.679 | -0.091 | 2 | 0.713 |
FYN |
0.678 | -0.085 | -1 | 0.568 |
FGFR3 |
0.677 | -0.126 | 3 | 0.765 |
ERBB2 |
0.677 | -0.129 | 1 | 0.615 |
MATK |
0.677 | -0.094 | -1 | 0.490 |
LYN |
0.677 | -0.081 | 3 | 0.724 |
INSR |
0.675 | -0.118 | 3 | 0.727 |
NTRK3 |
0.675 | -0.111 | -1 | 0.529 |
FLT4 |
0.674 | -0.152 | 3 | 0.737 |
YANK2 |
0.673 | -0.054 | 2 | 0.389 |
EPHA5 |
0.673 | -0.094 | 2 | 0.716 |
CK1G3 |
0.672 | -0.060 | -3 | 0.418 |
FLT1 |
0.672 | -0.172 | -1 | 0.533 |
CSK |
0.671 | -0.114 | 2 | 0.747 |
SRC |
0.670 | -0.095 | -1 | 0.577 |
EPHA8 |
0.670 | -0.095 | -1 | 0.526 |
EGFR |
0.669 | -0.097 | 1 | 0.547 |
MUSK |
0.667 | -0.087 | 1 | 0.524 |
PTK2 |
0.667 | -0.064 | -1 | 0.519 |
SYK |
0.665 | -0.086 | -1 | 0.488 |
FGFR4 |
0.662 | -0.119 | -1 | 0.510 |
FES |
0.661 | -0.062 | -1 | 0.498 |
IGF1R |
0.661 | -0.122 | 3 | 0.664 |
EPHA2 |
0.660 | -0.101 | -1 | 0.490 |
ERBB4 |
0.653 | -0.101 | 1 | 0.558 |
CK1G2 |
0.648 | -0.088 | -3 | 0.508 |
ZAP70 |
0.644 | -0.093 | -1 | 0.459 |