Motif 854 (n=155)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0B4J269 | None | Y687 | ochoa | Melanocyte-stimulating hormone receptor (Melanocortin receptor 1) | Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes. {ECO:0000256|ARBA:ARBA00023428}. |
| F8WAN1 | SPECC1L-ADORA2A | S55 | ochoa | SPECC1L-ADORA2A readthrough (NMD candidate) | None |
| H7C1D1 | None | S35 | ochoa | DUF4657 domain-containing protein | None |
| O00151 | PDLIM1 | S215 | ochoa | PDZ and LIM domain protein 1 (C-terminal LIM domain protein 1) (Elfin) (LIM domain protein CLP-36) | Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (PubMed:10861853). Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts (By similarity). {ECO:0000250|UniProtKB:P52944, ECO:0000269|PubMed:10861853}. |
| O00567 | NOP56 | S314 | ochoa | Nucleolar protein 56 (Nucleolar protein 5A) | Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs (PubMed:12777385, PubMed:15574333). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs) (PubMed:12777385, PubMed:39570315). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:15574333, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:39570315}. |
| O14523 | C2CD2L | S59 | ochoa | Phospholipid transfer protein C2CD2L (C2 domain-containing protein 2-like) (C2CD2-like) (Transmembrane protein 24) | Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane (PubMed:28209843). It thereby maintains the pool of cell membrane phosphoinositides, which are degraded during phospholipase C (PLC) signaling (PubMed:28209843). Plays a key role in the coordination of Ca(2+) and phosphoinositide signaling: localizes to sites of contact between the endoplasmic reticulum and the cell membrane, where it tethers the two bilayers (PubMed:28209843). In response to elevation of cytosolic Ca(2+), it is phosphorylated at its C-terminus and dissociates from the cell membrane, abolishing phosphatidylinositol transport to the cell membrane (PubMed:28209843). Positively regulates insulin secretion in response to glucose: phosphatidylinositol transfer to the cell membrane allows replenishment of PI(4,5)P2 pools and calcium channel opening, priming a new population of insulin granules (PubMed:28209843). {ECO:0000269|PubMed:28209843}. |
| O14526 | FCHO1 | S622 | ochoa | F-BAR domain only protein 1 | Functions in an early step of clathrin-mediated endocytosis (PubMed:30822429). Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors. Involved in the regulation of T-cell poliferation and activation (PubMed:30822429, PubMed:32098969). Affects TCR clustering upon receptor triggering and modulates its internalisation, playing a role in TCR-dependent T-cell activation (PubMed:32098969). {ECO:0000269|PubMed:20448150, ECO:0000269|PubMed:30822429, ECO:0000269|PubMed:32098969}. |
| O15063 | GARRE1 | S210 | ochoa | Granule associated Rac and RHOG effector protein 1 (GARRE1) | Acts as an effector of RAC1 (PubMed:31871319). Associates with CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation (PubMed:29395067). May also play a role in miRNA silencing machinery (PubMed:29395067). {ECO:0000269|PubMed:29395067, ECO:0000269|PubMed:31871319}. |
| O43683 | BUB1 | S331 | ochoa|psp | Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) | Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (PubMed:35044816). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:17158872, ECO:0000269|PubMed:19487456, ECO:0000269|PubMed:20739936, ECO:0000269|PubMed:35044816}. |
| O75150 | RNF40 | S114 | psp | E3 ubiquitin-protein ligase BRE1B (BRE1-B) (EC 2.3.2.27) (95 kDa retinoblastoma-associated protein) (RBP95) (RING finger protein 40) (RING-type E3 ubiquitin transferase BRE1B) | Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. {ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:19410543}.; FUNCTION: (Microbial infection) Promotes the human herpesvirus 8 (KSHV) lytic cycle by inducing the expression of lytic viral genes including the latency switch gene RTA/ORF50. {ECO:0000269|PubMed:37888983}. |
| O75534 | CSDE1 | S516 | ochoa | Cold shock domain-containing protein E1 (N-ras upstream gene protein) (Protein UNR) | RNA-binding protein involved in translationally coupled mRNA turnover (PubMed:11051545, PubMed:15314026). Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (PubMed:11051545, PubMed:15314026). Required for efficient formation of stress granules (PubMed:29395067). {ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:15314026, ECO:0000269|PubMed:29395067}.; FUNCTION: (Microbial infection) Required for internal initiation of translation of human rhinovirus RNA. {ECO:0000269|PubMed:10049359}. |
| O75643 | SNRNP200 | S457 | ochoa | U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.4.13) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog) (U5 snRNP-specific 200 kDa protein) (U5-200KD) | Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome (PubMed:35241646). Plays a role in pre-mRNA splicing as a core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:28502770, PubMed:28781166, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30315277, PubMed:30705154, PubMed:30728453). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. {ECO:0000269|PubMed:16723661, ECO:0000269|PubMed:23045696, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:30728453, ECO:0000269|PubMed:35241646, ECO:0000269|PubMed:8670905, ECO:0000269|PubMed:9539711, ECO:0000305|PubMed:33509932}. |
| O75762 | TRPA1 | S428 | psp | Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Transformation-sensitive protein p120) (p120) (Wasabi receptor) | Ligand-activated Ca(2+)-permeable, nonselective cation channel involved in pain detection and possibly also in cold perception, oxygen concentration perception, cough, itch, and inner ear function (PubMed:17259981, PubMed:21195050, PubMed:21873995, PubMed:23199233, PubMed:25389312, PubMed:33152265). Has a relatively high Ca(2+) selectivity, with a preference for divalent over monovalent cations (Ca(2+) > Ba(2+) > Mg(2+) > NH4(+) > Li(+) > K(+)), the influx of cation into the cytoplasm leads to membrane depolarization (PubMed:19202543, PubMed:21195050). Has a central role in the pain response to endogenous inflammatory mediators, such as bradykinin and to a diverse array of irritants. Activated by a large variety of structurally unrelated electrophilic and non-electrophilic chemical compounds, such as allylthiocyanate (AITC) from mustard oil or wasabi, cinnamaldehyde, diallyl disulfide (DADS) from garlic, and acrolein, an environmental irritant (PubMed:20547126, PubMed:25389312, PubMed:27241698, PubMed:30878828). Electrophilic ligands activate TRPA1 by interacting with critical N-terminal Cys residues in a covalent manner (PubMed:17164327, PubMed:27241698, PubMed:31866091, PubMed:32641835). Non-electrophile agonists bind at distinct sites in the transmembrane domain to promote channel activation (PubMed:33152265). Also acts as an ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana (PubMed:25389312). May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds (By similarity). {ECO:0000250|UniProtKB:Q8BLA8, ECO:0000269|PubMed:17164327, ECO:0000269|PubMed:17259981, ECO:0000269|PubMed:19202543, ECO:0000269|PubMed:20547126, ECO:0000269|PubMed:21195050, ECO:0000269|PubMed:21873995, ECO:0000269|PubMed:23199233, ECO:0000269|PubMed:25389312, ECO:0000269|PubMed:27241698, ECO:0000269|PubMed:30878828, ECO:0000269|PubMed:31866091, ECO:0000269|PubMed:32641835, ECO:0000269|PubMed:33152265}. |
| O75821 | EIF3G | S266 | ochoa | Eukaryotic translation initiation factor 3 subunit G (eIF3g) (Eukaryotic translation initiation factor 3 RNA-binding subunit) (eIF-3 RNA-binding subunit) (Eukaryotic translation initiation factor 3 subunit 4) (eIF-3-delta) (eIF3 p42) (eIF3 p44) | RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). This subunit can bind 18S rRNA. {ECO:0000255|HAMAP-Rule:MF_03006, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}. |
| O75937 | DNAJC8 | S52 | ochoa | DnaJ homolog subfamily C member 8 (Splicing protein spf31) | Suppresses polyglutamine (polyQ) aggregation of ATXN3 in neuronal cells (PubMed:27133716). {ECO:0000269|PubMed:27133716}. |
| O95235 | KIF20A | S670 | ochoa | Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6) | Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:12939256}. |
| P00338 | LDHA | S161 | ochoa|psp | L-lactate dehydrogenase A chain (LDH-A) (EC 1.1.1.27) (Cell proliferation-inducing gene 19 protein) (LDH muscle subunit) (LDH-M) (Renal carcinoma antigen NY-REN-59) | Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). {ECO:0000269|PubMed:11276087}. |
| P04350 | TUBB4A | Y340 | ochoa | Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P07195 | LDHB | S162 | ochoa|psp | L-lactate dehydrogenase B chain (LDH-B) (EC 1.1.1.27) (LDH heart subunit) (LDH-H) (Renal carcinoma antigen NY-REN-46) | Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). {ECO:0000269|PubMed:27618187}. |
| P07437 | TUBB | Y340 | ochoa | Tubulin beta chain (Tubulin beta-5 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P07864 | LDHC | S161 | ochoa | L-lactate dehydrogenase C chain (LDH-C) (EC 1.1.1.27) (Cancer/testis antigen 32) (CT32) (LDH testis subunit) (LDH-X) | Possible role in sperm motility. |
| P08240 | SRPRA | S286 | ochoa | Signal recognition particle receptor subunit alpha (SR-alpha) (Docking protein alpha) (DP-alpha) | Component of the signal recognition particle (SRP) complex receptor (SR) (PubMed:16439358). Ensures, in conjunction with the SRP complex, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (PubMed:16675701, PubMed:34020957). Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SRP subunit SRP54 (PubMed:34020957). SRP receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER (PubMed:34020957). {ECO:0000269|PubMed:16439358, ECO:0000269|PubMed:16675701, ECO:0000269|PubMed:34020957}. |
| P08865 | RPSA | S138 | ochoa | Small ribosomal subunit protein uS2 (37 kDa laminin receptor precursor) (37LRP) (37/67 kDa laminin receptor) (LRP/LR) (40S ribosomal protein SA) (67 kDa laminin receptor) (67LR) (Colon carcinoma laminin-binding protein) (Laminin receptor 1) (LamR) (Laminin-binding protein precursor p40) (LBP/p40) (Multidrug resistance-associated protein MGr1-Ag) (NEM/1CHD4) | Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. {ECO:0000255|HAMAP-Rule:MF_03016, ECO:0000269|PubMed:16263087, ECO:0000269|PubMed:6300843}.; FUNCTION: (Microbial infection) Acts as a receptor for the Adeno-associated viruses 2,3,8 and 9. {ECO:0000269|PubMed:16973587}.; FUNCTION: (Microbial infection) Acts as a receptor for the Dengue virus. {ECO:0000269|PubMed:15507651}.; FUNCTION: (Microbial infection) Acts as a receptor for the Sindbis virus. {ECO:0000269|PubMed:1385835}.; FUNCTION: (Microbial infection) Acts as a receptor for the Venezuelan equine encephalitis virus. {ECO:0000269|PubMed:1385835}.; FUNCTION: (Microbial infection) Acts as a receptor for the pathogenic prion protein. {ECO:0000269|PubMed:11689427, ECO:0000269|PubMed:9396609}.; FUNCTION: (Microbial infection) Acts as a receptor for bacteria. {ECO:0000269|PubMed:15516338}. |
| P09417 | QDPR | S223 | ochoa | Dihydropteridine reductase (EC 1.5.1.34) (HDHPR) (Quinoid dihydropteridine reductase) (Short chain dehydrogenase/reductase family 33C member 1) | Catalyzes the conversion of quinonoid dihydrobiopterin into tetrahydrobiopterin. {ECO:0000269|PubMed:3033643, ECO:0000269|PubMed:8262916}. |
| P09467 | FBP1 | S170 | psp | Fructose-1,6-bisphosphatase 1 (FBPase 1) (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase 1) (Liver FBPase) | Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain. {ECO:0000269|PubMed:16497803, ECO:0000269|PubMed:18375435, ECO:0000269|PubMed:22517657}. |
| P0DPH7 | TUBA3C | T82 | ochoa | Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P0DPH8 | TUBA3D | T82 | ochoa | Tubulin alpha-3D chain (EC 3.6.5.-) (Alpha-tubulin 3D) [Cleaved into: Detyrosinated tubulin alpha-3D chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P12956 | XRCC6 | S78 | psp | X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6) | Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Required for double-strand break repair and V(D)J recombination (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Also has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). It works in the 3'-5' direction (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Binding to DNA may be mediated by XRCC6 (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The XRCC5-XRRC6 dimer acts as a regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks (PubMed:20383123). 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined (PubMed:20383123). The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488). In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:12145306). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Negatively regulates apoptosis by interacting with BAX and sequestering it from the mitochondria (PubMed:15023334). Might have deubiquitination activity, acting on BAX (PubMed:18362350). {ECO:0000269|PubMed:11493912, ECO:0000269|PubMed:12145306, ECO:0000269|PubMed:15023334, ECO:0000269|PubMed:18362350, ECO:0000269|PubMed:20383123, ECO:0000269|PubMed:20493174, ECO:0000269|PubMed:2466842, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:7957065, ECO:0000269|PubMed:8621488, ECO:0000269|PubMed:9742108}. |
| P14635 | CCNB1 | S147 | psp | G2/mitotic-specific cyclin-B1 | Essential for the control of the cell cycle at the G2/M (mitosis) transition. {ECO:0000269|PubMed:17495531, ECO:0000269|PubMed:17495533, ECO:0000269|PubMed:27030811}. |
| P25054 | APC | S874 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P25054 | APC | S908 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P25815 | S100P | S24 | ochoa | Protein S100-P (Migration-inducing gene 9 protein) (MIG9) (Protein S100-E) (S100 calcium-binding protein P) | May function as calcium sensor and contribute to cellular calcium signaling. In a calcium-dependent manner, functions by interacting with other proteins, such as EZR and PPP5C, and indirectly plays a role in physiological processes like the formation of microvilli in epithelial cells. May stimulate cell proliferation in an autocrine manner via activation of the receptor for activated glycation end products (RAGE). {ECO:0000269|PubMed:14617629, ECO:0000269|PubMed:19111582, ECO:0000269|PubMed:22399290}. |
| P28290 | ITPRID2 | S593 | ochoa|psp | Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) | None |
| P28715 | ERCC5 | S384 | ochoa | DNA excision repair protein ERCC-5 (EC 3.1.-.-) (DNA repair protein complementing XP-G cells) (XPG) (Xeroderma pigmentosum group G-complementing protein) | Single-stranded structure-specific DNA endonuclease involved in DNA excision repair (PubMed:32522879, PubMed:32821917, PubMed:7651464, PubMed:8078765, PubMed:8090225, PubMed:8206890). Makes the 3'incision in DNA nucleotide excision repair (NER) (PubMed:32522879, PubMed:32821917, PubMed:8078765, PubMed:8090225). Binds and bends DNA repair bubble substrate and breaks base stacking at the single-strand/double-strand DNA junction of the DNA bubble (PubMed:32522879). Plays a role in base excision repair (BER) by promoting the binding of DNA glycosylase NTHL1 to its substrate and increasing NTHL1 catalytic activity that removes oxidized pyrimidines from DNA (PubMed:9927729). Involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (PubMed:16246722). Functions during the initial step of TCR in cooperation with ERCC6/CSB to recognized stalled RNA polymerase II (PubMed:16246722). Also, stimulates ERCC6/CSB binding to the DNA repair bubble and ERCC6/CSB ATPase activity (PubMed:16246722). Required for DNA replication fork maintenance and preservation of genomic stability (PubMed:26833090, PubMed:32522879). Involved in homologous recombination repair (HRR) induced by DNA replication stress by recruiting RAD51, BRCA2, and PALB2 to the damaged DNA site (PubMed:26833090). In TFIIH stimulates the 5'-3' helicase activity of XPD/ERCC2 and the DNA translocase activity of XPB/ERCC3 (PubMed:31253769). During HRR, binds to the replication fork with high specificity and stabilizes it (PubMed:32522879). Also, acts upstream of HRR, to promote the release of BRCA1 from DNA (PubMed:26833090). {ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:26833090, ECO:0000269|PubMed:31253769, ECO:0000269|PubMed:32522879, ECO:0000269|PubMed:32821917, ECO:0000269|PubMed:7651464, ECO:0000269|PubMed:8078765, ECO:0000269|PubMed:8090225, ECO:0000269|PubMed:8206890, ECO:0000269|PubMed:9927729}. |
| P43489 | TNFRSF4 | S258 | ochoa | Tumor necrosis factor receptor superfamily member 4 (ACT35 antigen) (OX40L receptor) (TAX transcriptionally-activated glycoprotein 1 receptor) (CD antigen CD134) | Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity. {ECO:0000269|PubMed:7704935}.; FUNCTION: (Microbial infection) Acts as a receptor for human herpesvirus 6B/HHV-6B. {ECO:0000269|PubMed:23674671}. |
| P49327 | FASN | S2123 | ochoa | Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] | Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269|PubMed:16215233, ECO:0000269|PubMed:16969344, ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
| P50479 | PDLIM4 | S210 | ochoa | PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein) | [Isoform 1]: Suppresses SRC activation by recognizing and binding to active SRC and facilitating PTPN13-mediated dephosphorylation of SRC 'Tyr-419' leading to its inactivation. Inactivated SRC dissociates from this protein allowing the initiation of a new SRC inactivation cycle (PubMed:19307596). Involved in reorganization of the actin cytoskeleton (PubMed:21636573). In nonmuscle cells, binds to ACTN1 (alpha-actinin-1), increases the affinity of ACTN1 to F-actin (filamentous actin), and promotes formation of actin stress fibers. Involved in regulation of the synaptic AMPA receptor transport in dendritic spines of hippocampal pyramidal neurons directing the receptors toward an insertion at the postsynaptic membrane. Links endosomal surface-internalized GRIA1-containing AMPA receptors to the alpha-actinin/actin cytoskeleton. Increases AMPA receptor-mediated excitatory postsynaptic currents in neurons (By similarity). {ECO:0000250|UniProtKB:P36202, ECO:0000269|PubMed:19307596, ECO:0000269|PubMed:21636573}.; FUNCTION: [Isoform 2]: Involved in reorganization of the actin cytoskeleton and in regulation of cell migration. In response to oxidative stress, binds to NQO1, which stabilizes it and protects it from ubiquitin-independent degradation by the core 20S proteasome. Stabilized protein is able to heterodimerize with isoform 1 changing the subcellular location of it from cytoskeleton and nuclei to cytosol, leading to loss of isoforms 1 ability to induce formation of actin stress fibers. Counteracts the effects produced by isoform 1 on organization of actin cytoskeleton and cell motility to fine-tune actin cytoskeleton rearrangement and to attenuate cell migration. {ECO:0000269|PubMed:21636573}. |
| P50990 | CCT8 | S380 | ochoa | T-complex protein 1 subunit theta (TCP-1-theta) (EC 3.6.1.-) (CCT-theta) (Chaperonin containing T-complex polypeptide 1 subunit 8) (Renal carcinoma antigen NY-REN-15) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P54198 | HIRA | S111 | ochoa | Protein HIRA (TUP1-like enhancer of split protein 1) | Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. {ECO:0000269|PubMed:12370293, ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15621527}. |
| P60842 | EIF4A1 | S322 | ochoa | Eukaryotic initiation factor 4A-I (eIF-4A-I) (eIF4A-I) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-1) | ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome (PubMed:20156963). In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. As a result, promotes cell proliferation and growth (PubMed:20156963). {ECO:0000269|PubMed:19153607, ECO:0000269|PubMed:19204291, ECO:0000269|PubMed:20156963}. |
| P61018 | RAB4B | S193 | ochoa | Ras-related protein Rab-4B (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB4B mediates endosomal tethering and fusion through the interaction with RUFY1 and RAB14 (PubMed:20534812). Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (By similarity). {ECO:0000250|UniProtKB:P20338, ECO:0000250|UniProtKB:Q91ZR1, ECO:0000269|PubMed:20534812}. |
| P61221 | ABCE1 | S423 | ochoa | ATP-binding cassette sub-family E member 1 (EC 3.6.5.-) (2'-5'-oligoadenylate-binding protein) (HuHP68) (RNase L inhibitor) (Ribonuclease 4 inhibitor) (RNS4I) | Nucleoside-triphosphatase (NTPase) involved in ribosome recycling by mediating ribosome disassembly (PubMed:20122402, PubMed:21448132). Able to hydrolyze ATP, GTP, UTP and CTP (PubMed:20122402). Splits ribosomes into free 60S subunits and tRNA- and mRNA-bound 40S subunits (PubMed:20122402, PubMed:21448132). Acts either after canonical termination facilitated by release factors (ETF1/eRF1) or after recognition of stalled and vacant ribosomes by mRNA surveillance factors (PELO/Pelota) (PubMed:20122402, PubMed:21448132). Involved in the No-Go Decay (NGD) pathway: recruited to stalled ribosomes by the Pelota-HBS1L complex, and drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (PubMed:21448132). Also plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA (PubMed:29861391). As part of the PINK1-regulated signaling, ubiquitinated by CNOT4 upon mitochondria damage; this modification generates polyubiquitin signals that recruit autophagy receptors to the mitochondrial outer membrane and initiate mitophagy (PubMed:29861391). RNASEL-specific protein inhibitor which antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) to RNASEL (PubMed:9660177). Negative regulator of the anti-viral effect of the interferon-regulated 2-5A/RNASEL pathway (PubMed:11585831, PubMed:9660177, PubMed:9847332). {ECO:0000269|PubMed:11585831, ECO:0000269|PubMed:20122402, ECO:0000269|PubMed:21448132, ECO:0000269|PubMed:29861391, ECO:0000269|PubMed:9660177, ECO:0000269|PubMed:9847332}.; FUNCTION: (Microbial infection) May act as a chaperone for post-translational events during HIV-1 capsid assembly. {ECO:0000269|PubMed:9847332}.; FUNCTION: (Microbial infection) Plays a role in the down-regulation of the 2-5A/RNASEL pathway during encephalomyocarditis virus (EMCV) and HIV-1 infections. {ECO:0000269|PubMed:9660177}. |
| P68363 | TUBA1B | T82 | ochoa | Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| P68371 | TUBB4B | Y340 | ochoa | Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q09666 | AHNAK | S4522 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S5669 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q13322 | GRB10 | S428 | ochoa|psp | Growth factor receptor-bound protein 10 (GRB10 adapter protein) (Insulin receptor-binding protein Grb-IR) | Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2. {ECO:0000269|PubMed:12493740, ECO:0000269|PubMed:15060076, ECO:0000269|PubMed:16434550, ECO:0000269|PubMed:17376403}. |
| Q13509 | TUBB3 | Y340 | ochoa|psp | Tubulin beta-3 chain (Tubulin beta-4 chain) (Tubulin beta-III) | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:34996871, PubMed:38305685, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:34996871, PubMed:38305685, PubMed:38609661). Below the cap, alpha-beta tubulin heterodimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). TUBB3 plays a critical role in proper axon guidance and maintenance (PubMed:20074521). Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Plays a role in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). {ECO:0000269|PubMed:20074521, ECO:0000269|PubMed:28483977, ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| Q13885 | TUBB2A | Y340 | ochoa | Tubulin beta-2A chain (Tubulin beta class IIa) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q14012 | CAMK1 | S333 | ochoa | Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha) | Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on 'Ser-694', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on 'Ser-91', 'Ser-92', 'Ser-93' and 'Ser-294'. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of 'Ser-259' and 'Ser-498' in the regulation of muscle cell differentiation. Regulates NUMB-mediated endocytosis by phosphorylation of NUMB on 'Ser-276' and 'Ser-295'. Involved in the regulation of basal and estrogen-stimulated migration of medulloblastoma cells through ARHGEF7/BETAPIX phosphorylation (By similarity). Is required for proper activation of cyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts. Plays a role in K(+) and ANG2-mediated regulation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin I. {ECO:0000250, ECO:0000269|PubMed:11114197, ECO:0000269|PubMed:12193581, ECO:0000269|PubMed:14507913, ECO:0000269|PubMed:14754892, ECO:0000269|PubMed:17056143, ECO:0000269|PubMed:17442826, ECO:0000269|PubMed:18184567, ECO:0000269|PubMed:20181577}. |
| Q14240 | EIF4A2 | S323 | ochoa | Eukaryotic initiation factor 4A-II (eIF-4A-II) (eIF4A-II) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-2) | ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. |
| Q14320 | FAM50A | S63 | ochoa | Protein FAM50A (Protein HXC-26) (Protein XAP-5) | Probably involved in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:32703943}. |
| Q14449 | GRB14 | S372 | ochoa|psp | Growth factor receptor-bound protein 14 (GRB14 adapter protein) | Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal. {ECO:0000269|PubMed:15210700, ECO:0000269|PubMed:19648926}. |
| Q14500 | KCNJ12 | S64 | psp | ATP-sensitive inward rectifier potassium channel 12 (Inward rectifier K(+) channel Kir2.2) (IRK-2) (Inward rectifier K(+) channel Kir2.2v) (Potassium channel, inwardly rectifying subfamily J member 12) | Inward rectifying potassium channel that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. {ECO:0000269|PubMed:12417321, ECO:0000269|PubMed:20921230, ECO:0000269|PubMed:7859381, ECO:0000269|PubMed:8647284}. |
| Q14517 | FAT1 | S1170 | ochoa | Protocadherin Fat 1 (Cadherin family member 7) (Cadherin-related tumor suppressor homolog) (Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form] | [Protocadherin Fat 1]: Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact. {ECO:0000250}. |
| Q14571 | ITPR2 | S1014 | ochoa | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2 (IP3 receptor isoform 2) (IP3R 2) (InsP3R2) (Inositol 1,4,5-trisphosphate receptor type 2) (Type 2 inositol 1,4,5-trisphosphate receptor) (Type 2 InsP3 receptor) | Inositol 1,4,5-trisphosphate-gated calcium channel that upon inositol 1,4,5-trisphosphate binding transports calcium from the endoplasmic reticulum lumen to cytoplasm. Exists in two states; a long-lived closed state where the channel is essentially 'parked' with only very rare visits to an open state and that ligands facilitate the transition from the 'parked' state into a 'drive' mode represented by periods of bursting activity (By similarity). {ECO:0000250|UniProtKB:Q9Z329}. |
| Q14573 | ITPR3 | S1702 | ochoa | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3 (IP3 receptor isoform 3) (IP3R-3) (InsP3R3) (Type 3 inositol 1,4,5-trisphosphate receptor) (Type 3 InsP3 receptor) | Inositol 1,4,5-trisphosphate-gated calcium channel that, upon 1D-myo-inositol 1,4,5-trisphosphate binding, transports calcium from the endoplasmic reticulum lumen to cytoplasm, thus releasing the intracellular calcium and therefore participates in cellular calcium ion homeostasis (PubMed:32949214, PubMed:37898605, PubMed:8081734, PubMed:8288584). 1D-myo-inositol 1,4,5-trisphosphate binds to the ligand-free channel without altering its global conformation, yielding the low-energy resting state, then progresses through resting-to preactivated transitions to the higher energy preactivated state, which increases affinity for calcium, promoting binding of the low basal cytosolic calcium at the juxtamembrane domain (JD) site, favoring the transition through the ensemble of high-energy intermediate states along the trajectory to the fully-open activated state (PubMed:30013099, PubMed:35301323, PubMed:37898605). Upon opening, releases calcium in the cytosol where it can bind to the low-affinity cytoplasmic domain (CD) site and stabilizes the inhibited state to terminate calcium release (PubMed:30013099, PubMed:35301323, PubMed:37898605). {ECO:0000269|PubMed:30013099, ECO:0000269|PubMed:32949214, ECO:0000269|PubMed:35301323, ECO:0000269|PubMed:37898605, ECO:0000269|PubMed:8081734, ECO:0000269|PubMed:8288584}. |
| Q14671 | PUM1 | S124 | ochoa | Pumilio homolog 1 (HsPUM) (Pumilio-1) | Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (PubMed:18328718, PubMed:21397187, PubMed:21572425, PubMed:21653694). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:20818387, PubMed:20860814, PubMed:22345517). Following growth factor stimulation, phosphorylated and binds to the 3'-UTR of CDKN1B/p27 mRNA, inducing a local conformational change that exposes miRNA-binding sites, promoting association of miR-221 and miR-222, efficient suppression of CDKN1B/p27 expression, and rapid entry to the cell cycle (PubMed:20818387). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517, PubMed:29474920). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm (PubMed:26724866). Involved in neuronal functions by regulating ATXN1 mRNA levels: acts by binding to the 3'-UTR of ATXN1 transcripts, leading to their down-regulation independently of the miRNA machinery (PubMed:25768905, PubMed:29474920). Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845). In testis, acts as a post-transcriptional regulator of spermatogenesis by binding to the 3'-UTR of mRNAs coding for regulators of p53/TP53. Involved in embryonic stem cell renewal by facilitating the exit from the ground state: acts by targeting mRNAs coding for naive pluripotency transcription factors and accelerates their down-regulation at the onset of differentiation (By similarity). Binds specifically to miRNA MIR199A precursor, with PUM2, regulates miRNA MIR199A expression at a postranscriptional level (PubMed:28431233). {ECO:0000250|UniProtKB:Q80U78, ECO:0000269|PubMed:18328718, ECO:0000269|PubMed:18776931, ECO:0000269|PubMed:20818387, ECO:0000269|PubMed:20860814, ECO:0000269|PubMed:21397187, ECO:0000269|PubMed:21572425, ECO:0000269|PubMed:21653694, ECO:0000269|PubMed:22345517, ECO:0000269|PubMed:22955276, ECO:0000269|PubMed:25340845, ECO:0000269|PubMed:25768905, ECO:0000269|PubMed:26724866, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:29474920}. |
| Q15075 | EEA1 | S52 | ochoa | Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2) | Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking. |
| Q15397 | PUM3 | S506 | ochoa | Pumilio homolog 3 (HBV X-transactivated gene 5 protein) (HBV XAg-transactivated protein 5) (Minor histocompatibility antigen HA-8) (HLA-HA8) | Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress (PubMed:21266351). Binds to double-stranded RNA or DNA without sequence specificity (PubMed:25512524). Involved in development of the eye and of primordial germ cells (By similarity). {ECO:0000250|UniProtKB:X1WGX5, ECO:0000269|PubMed:21266351, ECO:0000269|PubMed:25512524}. |
| Q15648 | MED1 | S953 | ochoa|psp | Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}. |
| Q2M1Z3 | ARHGAP31 | S387 | ochoa | Rho GTPase-activating protein 31 (Cdc42 GTPase-activating protein) | Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading, polarized lamellipodia formation and cell migration. {ECO:0000269|PubMed:12192056, ECO:0000269|PubMed:16519628}. |
| Q2NKX8 | ERCC6L | S820 | ochoa | DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15) | DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase (PubMed:17218258, PubMed:23973328). Functions as ATP-dependent DNA translocase (PubMed:23973328, PubMed:28977671). Can promote Holliday junction branch migration (in vitro) (PubMed:23973328). {ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:23973328, ECO:0000269|PubMed:28977671}. |
| Q4KMP7 | TBC1D10B | S248 | ochoa | TBC1 domain family member 10B (Rab27A-GAP-beta) | Acts as a GTPase-activating protein for RAB3A, RAB22A, RAB27A, and RAB35. Does not act on RAB2A and RAB6A. {ECO:0000269|PubMed:16923811, ECO:0000269|PubMed:19077034}. |
| Q53GG5 | PDLIM3 | S252 | ochoa | PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha-actinin-2-associated LIM protein) | May play a role in the organization of actin filament arrays within muscle cells. {ECO:0000250}. |
| Q5TH69 | ARFGEF3 | S1049 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 3 (ARFGEF family member 3) | Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (By similarity). Also regulates glucagon granule production in pancreatic alpha cells (By similarity). Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells (PubMed:19496786). {ECO:0000250|UniProtKB:Q3UGY8, ECO:0000269|PubMed:19496786}. |
| Q69YQ0 | SPECC1L | S55 | ochoa | Cytospin-A (Renal carcinoma antigen NY-REN-22) (Sperm antigen with calponin homology and coiled-coil domains 1-like) (SPECC1-like protein) | Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration. {ECO:0000269|PubMed:21703590}. |
| Q6KC79 | NIPBL | S244 | ochoa | Nipped-B-like protein (Delangin) (SCC2 homolog) | Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}. |
| Q6P1L5 | FAM117B | S510 | ochoa | Protein FAM117B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 13 protein) | None |
| Q6P2E9 | EDC4 | S565 | ochoa | Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls) | In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). {ECO:0000269|PubMed:16364915}. |
| Q6P597 | KLC3 | S466 | ochoa | Kinesin light chain 3 (KLC2-like) (kinesin light chain 2) | Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Plays a role during spermiogenesis in the development of the sperm tail midpiece and in the normal function of spermatozoa (By similarity). May play a role in the formation of the mitochondrial sheath formation in the developing spermatid midpiece (By similarity). {ECO:0000250|UniProtKB:Q91W40}. |
| Q6P9G4 | TMEM154 | S115 | ochoa | Transmembrane protein 154 | None |
| Q6PEY2 | TUBA3E | T82 | ochoa | Tubulin alpha-3E chain (EC 3.6.5.-) (Alpha-tubulin 3E) [Cleaved into: Detyrosinated tubulin alpha-3E chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q6WKZ4 | RAB11FIP1 | S500 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
| Q6ZMR3 | LDHAL6A | S161 | ochoa | L-lactate dehydrogenase A-like 6A (LDHA-like protein 6A) (EC 1.1.1.27) | Catalyzes the interconversion of L-lactate and pyruvate with nicotinamide adenine dinucleotide NAD(+) as a coenzyme (PubMed:18351441). Significantly increases the transcriptional activity of JUN, when overexpressed. {ECO:0000269|PubMed:18351441}. |
| Q70CQ4 | USP31 | S914 | ochoa | Ubiquitin carboxyl-terminal hydrolase 31 (EC 3.4.19.12) (Deubiquitinating enzyme 31) (Ubiquitin thioesterase 31) (Ubiquitin-specific-processing protease 31) | Deubiquitinase that recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. May play a role in the regulation of NF-kappa-B signaling pathway by deubiquitinating TRAF2. {ECO:0000269|PubMed:34184746}.; FUNCTION: (Microbial infection) Plays a positive role in foot-and-mouth disease and classical swine fever viral infection. Mechanistically, associates with internal ribosomal entry site (IRES) element within the 5'-untranslated region of viral genomes to promote translation of the virus-encoded polyprotein. {ECO:0000269|PubMed:35468926}. |
| Q71DI3 | H3C15 | S97 | ochoa | Histone H3.2 (H3-clustered histone 13) (H3-clustered histone 14) (H3-clustered histone 15) (Histone H3/m) (Histone H3/o) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q71U36 | TUBA1A | T82 | ochoa | Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q7L9B9 | EEPD1 | S149 | ochoa | Endonuclease/exonuclease/phosphatase family domain-containing protein 1 | None |
| Q7Z3G6 | PRICKLE2 | S740 | ochoa | Prickle-like protein 2 | None |
| Q7Z6I8 | C5orf24 | S144 | ochoa | UPF0461 protein C5orf24 | None |
| Q86SQ0 | PHLDB2 | S58 | ochoa | Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) | Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}. |
| Q86X29 | LSR | S401 | ochoa | Lipolysis-stimulated lipoprotein receptor (Angulin-1) | Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity). Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (By similarity). {ECO:0000250|UniProtKB:Q99KG5, ECO:0000250|UniProtKB:Q9WU74}. |
| Q86YV0 | RASAL3 | S228 | ochoa | RAS protein activator like-3 | Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down-stream ERK signaling pathway. {ECO:0000250|UniProtKB:Q8C2K5}. |
| Q8IW93 | ARHGEF19 | S350 | ochoa | Rho guanine nucleotide exchange factor 19 (Ephexin-2) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPase. {ECO:0000250}. |
| Q8IWU2 | LMTK2 | S561 | ochoa | Serine/threonine-protein kinase LMTK2 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase 2) (Brain-enriched kinase) (hBREK) (CDK5/p35-regulated kinase) (CPRK) (Kinase/phosphatase/inhibitor 2) (Lemur tyrosine kinase 2) (Serine/threonine-protein kinase KPI-2) | Phosphorylates PPP1C, phosphorylase b and CFTR. |
| Q8N4X5 | AFAP1L2 | S414 | ochoa | Actin filament-associated protein 1-like 2 (AFAP1-like protein 2) | May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation. {ECO:0000269|PubMed:17412687}. |
| Q8N5C1 | CALHM5 | S238 | ochoa | Calcium homeostasis modulator protein 5 (Protein FAM26E) | May assemble to form large pore channels with gating and ion conductance likely regulated by membrane lipids. {ECO:0000269|PubMed:33298887}. |
| Q8N6F7 | GCSAM | S157 | ochoa | Germinal center-associated signaling and motility protein (Germinal center B-cell-expressed transcript 2 protein) (Germinal center-associated lymphoma protein) (hGAL) | Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation. {ECO:0000269|PubMed:17823310, ECO:0000269|PubMed:20844236, ECO:0000269|PubMed:23299888}. |
| Q8N6H7 | ARFGAP2 | S340 | ochoa | ADP-ribosylation factor GTPase-activating protein 2 (ARF GAP 2) (GTPase-activating protein ZNF289) (Zinc finger protein 289) | GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. {ECO:0000269|PubMed:17760859}. |
| Q8NDX1 | PSD4 | S109 | ochoa | PH and SEC7 domain-containing protein 4 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 B) (Exchange factor for ARF6 B) (Pleckstrin homology and SEC7 domain-containing protein 4) (Telomeric of interleukin-1 cluster protein) | Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate. {ECO:0000269|PubMed:12082148, ECO:0000269|PubMed:21458045}. |
| Q8NFY4 | SEMA6D | S713 | ochoa | Semaphorin-6D | Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections. Ligand of TREM2 with PLXNA1 as coreceptor in dendritic cells, plays a role in the generation of immune responses and skeletal homeostasis (By similarity). {ECO:0000250|UniProtKB:Q76KF0}. |
| Q8TCU6 | PREX1 | S1200 | ochoa | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1) (PtdIns(3,4,5)-dependent Rac exchanger 1) | Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils. |
| Q8WWI1 | LMO7 | S919 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q92614 | MYO18A | S74 | ochoa | Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210) | May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939). {ECO:0000250|UniProtKB:Q9JMH9, ECO:0000269|PubMed:16087679, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:21123169, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:25965346, ECO:0000269|PubMed:27467939}. |
| Q92994 | BRF1 | S566 | ochoa | Transcription factor IIIB 90 kDa subunit (TFIIIB90) (hTFIIIB90) (B-related factor 1) (BRF-1) (hBRF) (TAF3B2) (TATA box-binding protein-associated factor, RNA polymerase III, subunit 2) | General activator of RNA polymerase which utilizes different TFIIIB complexes at structurally distinct promoters. The isoform 1 is involved in the transcription of tRNA, adenovirus VA1, 7SL and 5S RNA. Isoform 2 is required for transcription of the U6 promoter. |
| Q96BY6 | DOCK10 | S1236 | ochoa | Dedicator of cytokinesis protein 10 (Zizimin-3) | Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression. {ECO:0000250|UniProtKB:Q8BZN6}. |
| Q96GX5 | MASTL | S384 | ochoa | Serine/threonine-protein kinase greatwall (GW) (GWL) (hGWL) (EC 2.7.11.1) (Microtubule-associated serine/threonine-protein kinase-like) (MAST-L) | Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance (PubMed:19680222). Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively (PubMed:38123684). ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high (PubMed:20818157). Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation. {ECO:0000269|PubMed:12890928, ECO:0000269|PubMed:19680222, ECO:0000269|PubMed:19793917, ECO:0000269|PubMed:20538976, ECO:0000269|PubMed:20818157, ECO:0000269|PubMed:38123684}. |
| Q96II8 | LRCH3 | S65 | ochoa | DISP complex protein LRCH3 (Leucine-rich repeat and calponin homology domain-containing protein 3) | As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. {ECO:0000269|PubMed:29467281}. |
| Q96JY6 | PDLIM2 | S241 | ochoa | PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) | Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity. {ECO:0000269|PubMed:15659642}. |
| Q96PU5 | NEDD4L | S538 | ochoa | E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2) | E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins and is thereby implicated in the regulation of various signaling pathways including autophagy, innate immunity or DNA repair (PubMed:20064473, PubMed:31959741, PubMed:33608556). Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation (PubMed:15496141). Downregulates autophagy and cell growth by ubiquitinating and reducing cellular ULK1 or ASCT2 levels (PubMed:28820317, PubMed:31959741). Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5 (PubMed:26363003, PubMed:27445338). Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Involved in the regulation of TOR signaling (PubMed:27694961). Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF (PubMed:27445338). Plays a role in antiviral innate immunity by catalyzing 'Lys-29'-linked cysteine ubiquitination of TRAF3, resulting in enhanced 'Lys-48' and 'Lys-63'-linked ubiquitination of TRAF3 (PubMed:33608556). Ubiquitinates TTYH2 and TTYH3 and regulates protein levels of TTYH2 (PubMed:18577513). {ECO:0000250|UniProtKB:Q8CFI0, ECO:0000269|PubMed:12911626, ECO:0000269|PubMed:15040001, ECO:0000269|PubMed:15217910, ECO:0000269|PubMed:15489223, ECO:0000269|PubMed:15496141, ECO:0000269|PubMed:15576372, ECO:0000269|PubMed:18577513, ECO:0000269|PubMed:19144635, ECO:0000269|PubMed:23999003, ECO:0000269|PubMed:25631046, ECO:0000269|PubMed:26363003, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:27694961, ECO:0000269|PubMed:33608556}. |
| Q96RL1 | UIMC1 | S254 | ochoa | BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Retinoid X receptor-interacting protein 110) (Ubiquitin interaction motif-containing protein 1) | Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.38). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. {ECO:0000269|PubMed:12080054, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:17525342, ECO:0000269|PubMed:17621610, ECO:0000269|PubMed:17643121, ECO:0000269|PubMed:19015238, ECO:0000269|PubMed:19202061, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19328070, ECO:0000269|PubMed:24627472, ECO:0000269|Ref.38}. |
| Q96T83 | SLC9A7 | S573 | ochoa | Sodium/hydrogen exchanger 7 (Na(+)/H(+) exchanger 7) (NHE-7) (Solute carrier family 9 member 7) | Golgi Na(+), K(+)/(H+) antiporter. Mediates the electoneutral influx of Na(+) or K(+) in exchange for H(+). May contribute to the regulation of Golgi apparatus volume and pH. {ECO:0000269|PubMed:11279194, ECO:0000269|PubMed:30335141}. |
| Q96T88 | UHRF1 | S174 | ochoa | E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (Inverted CCAAT box-binding protein of 90 kDa) (Nuclear protein 95) (Nuclear zinc finger protein Np95) (HuNp95) (hNp95) (RING finger protein 106) (RING-type E3 ubiquitin transferase UHRF1) (Transcription factor ICBP90) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (hUHRF1) (Ubiquitin-like-containing PHD and RING finger domains protein 1) | Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications. Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins such as histone H3 and PML. It is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo. Plays a role in DNA repair by cooperating with UHRF2 to ensure recruitment of FANCD2 to interstrand cross-links (ICLs) leading to FANCD2 activation. Acts as a critical player of proper spindle architecture by catalyzing the 'Lys-63'-linked ubiquitination of KIF11, thereby controlling KIF11 localization on the spindle (PubMed:37728657). {ECO:0000269|PubMed:10646863, ECO:0000269|PubMed:15009091, ECO:0000269|PubMed:15361834, ECO:0000269|PubMed:17673620, ECO:0000269|PubMed:17967883, ECO:0000269|PubMed:19056828, ECO:0000269|PubMed:21745816, ECO:0000269|PubMed:21777816, ECO:0000269|PubMed:22945642, ECO:0000269|PubMed:30335751, ECO:0000269|PubMed:37728657}. |
| Q99816 | TSG101 | S48 | ochoa | Tumor susceptibility gene 101 protein (ESCRT-I complex subunit TSG101) | Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). It may also play a role in the extracellular release of microvesicles that differ from the exosomes (PubMed:22315426). {ECO:0000269|PubMed:11916981, ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:21070952, ECO:0000269|PubMed:21757351, ECO:0000269|PubMed:22315426, ECO:0000269|PubMed:22660413}. |
| Q9BQE3 | TUBA1C | T82 | ochoa | Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9BTV7 | CABLES2 | S259 | ochoa | CDK5 and ABL1 enzyme substrate 2 (Interactor with CDK3 2) (Ik3-2) | Unknown. Probably involved in G1-S cell cycle transition. |
| Q9BUF5 | TUBB6 | Y340 | ochoa | Tubulin beta-6 chain (Tubulin beta class V) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. {ECO:0000250|UniProtKB:P02557}. |
| Q9BVA1 | TUBB2B | Y340 | ochoa | Tubulin beta-2B chain | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:23001566, PubMed:26732629, PubMed:28013290). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910). {ECO:0000269|PubMed:19465910, ECO:0000269|PubMed:23001566, ECO:0000269|PubMed:26732629, ECO:0000269|PubMed:28013290}. |
| Q9BW04 | SARG | S462 | ochoa | Specifically androgen-regulated gene protein | Putative androgen-specific receptor. {ECO:0000269|PubMed:15525603}. |
| Q9BX40 | LSM14B | S165 | ochoa | Protein LSM14 homolog B (RNA-associated protein 55B) (hRAP55B) | mRNA-binding protein essential for female fertility, oocyte meiotic maturation and the assembly of MARDO (mitochondria-associated ribonucleoprotein domain), a membraneless compartment that stores maternal mRNAs in oocytes. Ensures the proper accumulation and clearance of mRNAs essential for oocyte meiotic maturation and the normal progression from Meiosis I to Meiosis II in oocytes. Promotes the translation of some oogenesis-related mRNAs. Regulates the expression and/or localization of some key P-body proteins in oocytes. Essential for the assembly of the primordial follicle in the ovary. {ECO:0000250|UniProtKB:Q8CGC4}. |
| Q9BX63 | BRIP1 | S1004 | ochoa | Fanconi anemia group J protein (EC 5.6.2.3) (BRCA1-associated C-terminal helicase 1) (BRCA1-interacting protein C-terminal helicase 1) (BRCA1-interacting protein 1) (DNA 5'-3' helicase FANCJ) | DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of chromosomal stability (PubMed:11301010, PubMed:14983014, PubMed:16116421, PubMed:16153896, PubMed:17596542, PubMed:36608669). Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination (PubMed:14983014, PubMed:16153896). Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1 (PubMed:14983014, PubMed:16153896). Involved in the repair of abasic sites at replication forks by promoting the degradation of DNA-protein cross-links: acts by catalyzing unfolding of HMCES DNA-protein cross-link via its helicase activity, exposing the underlying DNA and enabling cleavage of the DNA-protein adduct by the SPRTN metalloprotease (PubMed:16116421, PubMed:36608669). Can unwind RNA:DNA substrates (PubMed:14983014). Unwinds G-quadruplex DNA; unwinding requires a 5'-single stranded tail (PubMed:18426915, PubMed:20639400). {ECO:0000269|PubMed:11301010, ECO:0000269|PubMed:14983014, ECO:0000269|PubMed:16116421, ECO:0000269|PubMed:16153896, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639400, ECO:0000269|PubMed:36608669}. |
| Q9H2E6 | SEMA6A | S265 | ochoa | Semaphorin-6A (Semaphorin VIA) (Sema VIA) (Semaphorin-6A-1) (SEMA6A-1) | Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation. {ECO:0000250|UniProtKB:O35464}.; FUNCTION: (Microbial infection) Acts as a receptor for P.sordellii toxin TcsL in the in the vascular endothelium. {ECO:0000269|PubMed:32302524, ECO:0000269|PubMed:32589945}. |
| Q9H3K6 | BOLA2 | S34 | ochoa | BolA-like protein 2 | Acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (PubMed:26613676, PubMed:27519415). Acts together with the monothiol glutaredoxin GLRX3 (PubMed:26613676, PubMed:27519415). {ECO:0000269|PubMed:26613676, ECO:0000269|PubMed:27519415}. |
| Q9H3Q1 | CDC42EP4 | S118 | ochoa | Cdc42 effector protein 4 (Binder of Rho GTPases 4) | Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts. |
| Q9H582 | ZNF644 | S639 | ochoa | Zinc finger protein 644 (Zinc finger motif enhancer-binding protein 2) (Zep-2) | May be involved in transcriptional regulation. |
| Q9H7P9 | PLEKHG2 | S51 | ochoa | Pleckstrin homology domain-containing family G member 2 (PH domain-containing family G member 2) | May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein) (PubMed:18045877). Involved in the regulation of actin polymerization (PubMed:26573021). {ECO:0000250|UniProtKB:Q6KAU7, ECO:0000269|PubMed:18045877, ECO:0000269|PubMed:26573021}. |
| Q9NQT8 | KIF13B | S1391 | ochoa | Kinesin-like protein KIF13B (Kinesin-like protein GAKIN) | Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes. {ECO:0000269|PubMed:20194617}. |
| Q9NQV6 | PRDM10 | S1088 | ochoa | PR domain zinc finger protein 10 (PR domain-containing protein 10) (Tristanin) | Transcriptional activator, essential for early embryonic development and survival of embryonic stem cells (ESCs) (By similarity). Supports cell growth and survival during early development by transcriptionally activating the expression of the translation initiation factor EIF3B, to sustain global translation (By similarity). Activates the transcription of FLNC (PubMed:36440963). {ECO:0000250|UniProtKB:Q3UTQ7, ECO:0000269|PubMed:36440963}. |
| Q9NRM7 | LATS2 | S446 | psp | Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase) | Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:18158288, PubMed:26437443, PubMed:26598551, PubMed:34404733). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:26437443, PubMed:26598551, PubMed:34404733). Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:26598551, PubMed:34404733). Also phosphorylates YAP1 in response to cell contact inhibition-driven WWP1 ubiquitination of AMOTL2, which results in LATS2 activation (PubMed:34404733). Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability (PubMed:10871863). Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity (PubMed:12853976). Negative regulator of the androgen receptor (PubMed:15131260). Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities (PubMed:21952048). This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ (PubMed:21952048). Acts as an activator of the NLRP3 inflammasome by mediating phosphorylation of 'Ser-265' of NLRP3 following NLRP3 palmitoylation, promoting NLRP3 activation by NEK7 (PubMed:39173637). {ECO:0000269|PubMed:10871863, ECO:0000269|PubMed:12853976, ECO:0000269|PubMed:15131260, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:21952048, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:34404733, ECO:0000269|PubMed:39173637}. |
| Q9NY61 | AATF | S55 | ochoa | Protein AATF (Apoptosis-antagonizing transcription factor) (Rb-binding protein Che-1) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date. {ECO:0000269|PubMed:12450794, ECO:0000269|PubMed:12847090, ECO:0000269|PubMed:14627703, ECO:0000269|PubMed:15207272, ECO:0000269|PubMed:34516797}. |
| Q9NZ56 | FMN2 | S499 | ochoa | Formin-2 | Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization (PubMed:21730168, PubMed:22330775). Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2 (PubMed:21730168, PubMed:22330775). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis (By similarity). Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress-induced cell cycle arrest (PubMed:23375502). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). Protects cells against apoptosis by protecting CDKN1A against degradation (PubMed:23375502). {ECO:0000250|UniProtKB:Q9JL04, ECO:0000269|PubMed:21730168, ECO:0000269|PubMed:22330775, ECO:0000269|PubMed:23375502, ECO:0000269|PubMed:26287480}. |
| Q9NZV8 | KCND2 | S552 | psp | A-type voltage-gated potassium channel KCND2 (Potassium voltage-gated channel subfamily D member 2) (Voltage-gated potassium channel subunit Kv4.2) | Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Mediates the major part of the dendritic A-type current I(SA) in brain neurons (By similarity). This current is activated at membrane potentials that are below the threshold for action potentials. It regulates neuronal excitability, prolongs the latency before the first spike in a series of action potentials, regulates the frequency of repetitive action potential firing, shortens the duration of action potentials and regulates the back-propagation of action potentials from the neuronal cell body to the dendrites. Contributes to the regulation of the circadian rhythm of action potential firing in suprachiasmatic nucleus neurons, which regulates the circadian rhythm of locomotor activity (By similarity). Functions downstream of the metabotropic glutamate receptor GRM5 and plays a role in neuronal excitability and in nociception mediated by activation of GRM5 (By similarity). Mediates the transient outward current I(to) in rodent heart left ventricle apex cells, but not in human heart, where this current is mediated by another family member. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient (PubMed:10551270, PubMed:11507158, PubMed:14623880, PubMed:14695263, PubMed:14980201, PubMed:15454437, PubMed:16934482, PubMed:19171772, PubMed:24501278, PubMed:24811166, PubMed:34552243, PubMed:35597238). The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:11507158). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCND2 and KCND3; channel properties depend on the type of pore-forming alpha subunits that are part of the channel. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes. Interaction with specific isoforms of the regulatory subunits KCNIP1, KCNIP2, KCNIP3 or KCNIP4 strongly increases expression at the cell surface and thereby increases channel activity; it modulates the kinetics of channel activation and inactivation, shifts the threshold for channel activation to more negative voltage values, shifts the threshold for inactivation to less negative voltages and accelerates recovery after inactivation (PubMed:14623880, PubMed:14980201, PubMed:15454437, PubMed:19171772, PubMed:24501278, PubMed:24811166). Likewise, interaction with DPP6 or DPP10 promotes expression at the cell membrane and regulates both channel characteristics and activity (By similarity). Upon depolarization, the channel goes from a resting closed state (C state) to an activated but non-conducting state (C* state), from there, the channel may either inactivate (I state) or open (O state) (PubMed:35597238). {ECO:0000250|UniProtKB:Q63881, ECO:0000250|UniProtKB:Q9Z0V2, ECO:0000269|PubMed:10551270, ECO:0000269|PubMed:10729221, ECO:0000269|PubMed:11507158, ECO:0000269|PubMed:14623880, ECO:0000269|PubMed:14695263, ECO:0000269|PubMed:14980201, ECO:0000269|PubMed:15454437, ECO:0000269|PubMed:16934482, ECO:0000269|PubMed:19171772, ECO:0000269|PubMed:24501278, ECO:0000269|PubMed:24811166, ECO:0000269|PubMed:34552243, ECO:0000269|PubMed:35597238}. |
| Q9P2N6 | KANSL3 | S559 | ochoa | KAT8 regulatory NSL complex subunit 3 (NSL complex protein NSL3) (Non-specific lethal 3 homolog) (Serum inhibited-related protein) (Testis development protein PRTD) | Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (PubMed:20018852, PubMed:33657400). The NSL complex also acts as a regulator of gene expression in mitochondria (PubMed:27768893). Within the NSL complex, KANSL3 is required to promote KAT8 association with mitochondrial DNA (PubMed:27768893). Required for transcription of intraciliary transport genes in both ciliated and non-ciliated cells (By similarity). This is necessary for cilium assembly in ciliated cells and for organization of the microtubule cytoskeleton in non-ciliated cells (By similarity). Also required within the NSL complex to maintain nuclear architecture stability by promoting KAT8-mediated acetylation of lamin LMNA (By similarity). Plays an essential role in spindle assembly during mitosis (PubMed:26243146). Acts as a microtubule minus-end binding protein which stabilizes microtubules and promotes their assembly (PubMed:26243146). Indispensable during early embryonic development where it is required for proper lineage specification and maintenance during peri-implantation development and is essential for implantation (By similarity). {ECO:0000250|UniProtKB:A2RSY1, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:26243146, ECO:0000269|PubMed:27768893, ECO:0000269|PubMed:33657400}. |
| Q9UBU6 | FAM8A1 | S83 | ochoa | Protein FAM8A1 (Autosomal highly conserved protein) | Plays a role in the assembly of the HRD1 complex, a complex involved in the ubiquitin-proteasome-dependent process of ER-associated degradation (ERAD). {ECO:0000269|PubMed:28827405}. |
| Q9UEW8 | STK39 | S309 | psp | STE20/SPS1-related proline-alanine-rich protein kinase (Ste-20-related kinase) (EC 2.7.11.1) (DCHT) (Serine/threonine-protein kinase 39) | Effector serine/threonine-protein kinase component of the WNK-SPAK/OSR1 kinase cascade, which is involved in various processes, such as ion transport, response to hypertonic stress and blood pressure (PubMed:16669787, PubMed:18270262, PubMed:21321328, PubMed:34289367). Specifically recognizes and binds proteins with a RFXV motif (PubMed:16669787, PubMed:21321328). Acts downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4): following activation by WNK kinases, catalyzes phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:21321328). Mediates regulatory volume increase in response to hyperosmotic stress by catalyzing phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1 and SLC12A6/KCC3 downstream of WNK1 and WNK3 kinases (PubMed:12740379, PubMed:16669787, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:16669787, PubMed:19665974, PubMed:21321328). Acts as a regulator of NaCl reabsorption in the distal nephron by mediating phosphorylation and activation of the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney downstream of WNK4 (PubMed:18270262). Mediates the inhibition of SLC4A4, SLC26A6 as well as CFTR activities (By similarity). Phosphorylates RELT (By similarity). {ECO:0000250|UniProtKB:Q9Z1W9, ECO:0000269|PubMed:12740379, ECO:0000269|PubMed:16669787, ECO:0000269|PubMed:18270262, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:34289367}. |
| Q9UHR4 | BAIAP2L1 | S354 | ochoa | BAR/IMD domain-containing adapter protein 2-like 1 (Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1) (BAI1-associated protein 2-like protein 1) (Insulin receptor tyrosine kinase substrate) | May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. {ECO:0000269|PubMed:17430976, ECO:0000269|PubMed:19366662, ECO:0000269|PubMed:22921828}. |
| Q9ULU4 | ZMYND8 | S1119 | ochoa | MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8) | Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) (PubMed:26655721, PubMed:27477906, PubMed:31965980, PubMed:36064715). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac (PubMed:27477906). May also act as a transcriptional corepressor for KDM5C and EZH2 (PubMed:33323928). Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309, PubMed:27732854, PubMed:30134174). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (PubMed:26655721, PubMed:30134174). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression (PubMed:26655721). Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform (PubMed:30134174, PubMed:35916866, PubMed:36064715). Suppresses breast cancer, and prostate cancer cell invasion and metastasis (PubMed:27477906, PubMed:31965980, PubMed:33323928). {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:26655721, ECO:0000269|PubMed:27477906, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:31965980, ECO:0000269|PubMed:33323928, ECO:0000269|PubMed:35916866, ECO:0000269|PubMed:36064715}. |
| Q9UMS6 | SYNPO2 | S264 | ochoa | Synaptopodin-2 (Genethonin-2) (Myopodin) | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. |
| Q9UP65 | PLA2G4C | S337 | ochoa | Cytosolic phospholipase A2 gamma (cPLA2-gamma) (EC 3.1.1.4) (Cytosolic lysophospholipase) (EC 3.1.1.5) (Cytosolic lysophospholipid O-acyltransferase) (EC 2.3.1.-) (Phospholipase A2 group IVC) | Calcium-independent phospholipase, lysophospholipase and O-acyltransferase involved in phospholipid remodeling with implications in endoplasmic reticulum membrane homeostasis and lipid droplet biogenesis (PubMed:10085124, PubMed:10358058, PubMed:19501189, PubMed:28336330, PubMed:9705332). Preferentially hydrolyzes the ester bond of the fatty acyl group attached at the sn-2 position of phospholipids with choline and ethanolamine head groups, producing lysophospholipids that are used in deacylation-reacylation cycles (PubMed:10085124, PubMed:10358058, PubMed:19501189, PubMed:28336330, PubMed:9705332). Transfers the sn-1 fatty acyl from one lysophospholipid molecule to the sn-2 position of another lysophospholipid to form diacyl, alkylacyl and alkenylacyl glycerophospholipids. Cleaves ester bonds but not alkyl or alkenyl ether bonds at sn-1 position of lysophospholipids (PubMed:15944408, PubMed:19501189). Catalyzes sn-2 fatty acyl transfer from phospholipids to the sn-2 position of 1-O-alkyl or 1-O-alkenyl lysophospholipids with lower efficiency (PubMed:15944408, PubMed:19501189). In response to dietary fatty acids, may play a role in the formation of nascent lipid droplets from the endoplasmic reticulum likely by regulating the phospholipid composition of these organelles (PubMed:28336330). {ECO:0000269|PubMed:10085124, ECO:0000269|PubMed:10358058, ECO:0000269|PubMed:15944408, ECO:0000269|PubMed:19501189, ECO:0000269|PubMed:28336330, ECO:0000269|PubMed:9705332}.; FUNCTION: (Microbial infection) May play a role in replication and assembly of human hepatitis C virus (HCV) (PubMed:23015700, PubMed:28336330). In response to HCV infection, promotes remodeling of host endoplasmic reticulum membranes to form organelle-like structures called membranous web, where HCV replication occur (PubMed:23015700). Can further mediate translocation of replication complexes to lipid droplets to enable virion assembly (PubMed:23015700, PubMed:28336330). {ECO:0000269|PubMed:23015700, ECO:0000269|PubMed:28336330}.; FUNCTION: (Microbial infection) May facilitate human T-lymphotropic virus type 1 (HTLV-1) infection by promoting leukotriene B4 (LTB4) biosynthesis. LTB4 acts as a chemoattractant for HTLV-1-infected CD4-positive T cells and favors cell to cell viral transmission. {ECO:0000269|PubMed:28639618}. |
| Q9UPQ0 | LIMCH1 | S601 | ochoa | LIM and calponin homology domains-containing protein 1 | Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269|PubMed:28228547}. |
| Q9UQB8 | BAIAP2 | S454 | ochoa|psp | BAR/IMD domain-containing adapter protein 2 (Brain-specific angiogenesis inhibitor 1-associated protein 2) (BAI-associated protein 2) (BAI1-associated protein 2) (Protein BAP2) (Fas ligand-associated factor 3) (FLAF3) (Insulin receptor substrate p53/p58) (IRS-58) (IRSp53/58) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) | Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions. {ECO:0000269|PubMed:11130076, ECO:0000269|PubMed:11696321, ECO:0000269|PubMed:14752106, ECO:0000269|PubMed:17115031, ECO:0000269|PubMed:19366662}. |
| Q9UQC2 | GAB2 | S459 | ochoa | GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100) | Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. {ECO:0000269|PubMed:15750601, ECO:0000269|PubMed:19172738}. |
| Q9Y247 | FAM50B | S63 | ochoa | Protein FAM50B (Protein XAP-5-like) | None |
| Q9Y2X3 | NOP58 | S304 | ochoa | Nucleolar protein 58 (Nucleolar protein 5) | Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs (PubMed:15574333, PubMed:17636026, PubMed:19620283, PubMed:34516797). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs) (PubMed:39570315). {ECO:0000269|PubMed:15574333, ECO:0000269|PubMed:17636026, ECO:0000269|PubMed:19620283, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:39570315}. |
| Q9Y2X9 | ZNF281 | S117 | ochoa | Zinc finger protein 281 (GC-box-binding zinc finger protein 1) (Transcription factor ZBP-99) (Zinc finger DNA-binding protein 99) | Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs (By similarity). Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes. {ECO:0000250, ECO:0000269|PubMed:10448078, ECO:0000269|PubMed:12771217}. |
| Q9Y446 | PKP3 | S305 | ochoa | Plakophilin-3 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:24124604). Required for the localization of DSG2, DSP and PKP2 to mature desmosome junctions (PubMed:20859650). May also play a role in the maintenance of DSG3 protein abundance in keratinocytes (By similarity). Required for the formation of DSP-containing desmosome precursors in the cytoplasm during desmosome assembly (PubMed:25208567). Also regulates the accumulation of CDH1 to mature desmosome junctions, via cAMP-dependent signaling and its interaction with activated RAP1A (PubMed:25208567). Positively regulates the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with FXR1, may also regulate the protein abundance of DSP via the same mechanism (PubMed:25225333). May also regulate the protein abundance of the desmosome component PKP1 (By similarity). Required for the organization of desmosome junctions at intercellular borders between basal keratinocytes of the epidermis, as a result plays a role in maintenance of the dermal barrier and regulation of the dermal inflammatory response (By similarity). Required during epidermal keratinocyte differentiation for cell adherence at tricellular cell-cell contacts, via regulation of the timely formation of adherens junctions and desmosomes in a calcium-dependent manner, and may also play a role in the organization of the intracellular actin fiber belt (By similarity). Acts as a negative regulator of the inflammatory response in hematopoietic cells of the skin and intestine, via modulation of proinflammatory cytokine production (By similarity). Important for epithelial barrier maintenance in the intestine to reduce intestinal permeability, thereby plays a role in protection from intestinal-derived endotoxemia (By similarity). Required for the development of hair follicles, via a role in the regulation of inner root sheaf length, correct alignment and anterior-posterior polarity of hair follicles (By similarity). Promotes proliferation and cell-cycle G1/S phase transition of keratinocytes (By similarity). Promotes E2F1-driven transcription of G1/S phase promoting genes by acting to release E2F1 from its inhibitory interaction with RB1, via sequestering RB1 and CDKN1A to the cytoplasm and thereby increasing CDK4- and CDK6-driven phosphorylation of RB1 (By similarity). May act as a scaffold protein to facilitate MAPK phosphorylation of RPS6KA protein family members and subsequently promote downstream EGFR signaling (By similarity). May play a role in the positive regulation of transcription of Wnt-mediated TCF-responsive target genes (PubMed:34058472). {ECO:0000250|UniProtKB:Q9QY23, ECO:0000269|PubMed:20859650, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:34058472}. |
| Q9Y490 | TLN1 | S2279 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| Q9Y4H2 | IRS2 | S608 | ochoa | Insulin receptor substrate 2 (IRS-2) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}. |
| Q9Y6M5 | SLC30A1 | S468 | ochoa | Proton-coupled zinc antiporter SLC30A1 (Solute carrier family 30 member 1) (Zinc transporter 1) | Zinc ion:proton antiporter that could function at the plasma membrane mediating zinc efflux from cells against its electrochemical gradient protecting them from intracellular zinc accumulation and toxicity (PubMed:31471319). Alternatively, could prevent the transport to the plasma membrane of CACNB2, the L-type calcium channels regulatory subunit, through a yet to be defined mechanism. By modulating the expression of these channels at the plasma membrane, could prevent calcium and zinc influx into cells. By the same mechanism, could also prevent L-type calcium channels-mediated heavy metal influx into cells (By similarity). In some cells, could also function as a zinc ion:proton antiporter mediating zinc entry into the lumen of cytoplasmic vesicles. In macrophages, can increase zinc ions concentration into the lumen of cytoplasmic vesicles containing engulfed bacteria and could help inactivate them (PubMed:32441444). Forms a complex with TMC6/EVER1 and TMC8/EVER2 at the ER membrane of keratynocytes which facilitates zinc uptake into the ER (PubMed:18158319). Down-regulates the activity of transcription factors induced by zinc and cytokines (PubMed:18158319). {ECO:0000250|UniProtKB:Q62720, ECO:0000269|PubMed:18158319, ECO:0000269|PubMed:31471319, ECO:0000269|PubMed:32441444}. |
| Q9Y6Q9 | NCOA3 | S589 | ochoa | Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. |
| R4GMW8 | BIVM-ERCC5 | S838 | ochoa | DNA excision repair protein ERCC-5 | None |
| O14965 | AURKA | S266 | GPS6|ELM|EPSD|PSP | Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Breast tumor-amplified kinase) (Ipl1- and aurora-related kinase 1) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase Ayk1) (Serine/threonine-protein kinase aurora-A) | Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression (PubMed:11039908, PubMed:12390251, PubMed:17125279, PubMed:17360485, PubMed:18615013, PubMed:26246606). Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis (PubMed:14523000, PubMed:26246606). Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (PubMed:27335426). Required for initial activation of CDK1 at centrosomes (PubMed:13678582, PubMed:15128871). Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2 (PubMed:11551964, PubMed:14702041, PubMed:15128871, PubMed:15147269, PubMed:15987997, PubMed:17604723, PubMed:18056443, PubMed:18615013). Phosphorylates MCRS1 which is required for MCRS1-mediated kinetochore fiber assembly and mitotic progression (PubMed:27192185). Regulates KIF2A tubulin depolymerase activity (PubMed:19351716). Important for microtubule formation and/or stabilization (PubMed:18056443). Required for normal axon formation (PubMed:19812038). Plays a role in microtubule remodeling during neurite extension (PubMed:19668197). Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and destabilizing p53/TP53 (PubMed:14702041). Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity (PubMed:11551964). Inhibits cilia outgrowth (By similarity). Required for cilia disassembly via phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (PubMed:17604723, PubMed:20643351). Regulates protein levels of the anti-apoptosis protein BIRC5 by suppressing the expression of the SCF(FBXL7) E3 ubiquitin-protein ligase substrate adapter FBXL7 through the phosphorylation of the transcription factor FOXP1 (PubMed:28218735). {ECO:0000250|UniProtKB:A0A8I3S724, ECO:0000269|PubMed:11039908, ECO:0000269|PubMed:11551964, ECO:0000269|PubMed:12390251, ECO:0000269|PubMed:13678582, ECO:0000269|PubMed:14523000, ECO:0000269|PubMed:14702041, ECO:0000269|PubMed:15128871, ECO:0000269|PubMed:15147269, ECO:0000269|PubMed:15987997, ECO:0000269|PubMed:17125279, ECO:0000269|PubMed:17360485, ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:18615013, ECO:0000269|PubMed:19351716, ECO:0000269|PubMed:19668197, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:20643351, ECO:0000269|PubMed:26246606, ECO:0000269|PubMed:27192185, ECO:0000269|PubMed:27335426, ECO:0000269|PubMed:28218735}. |
| Q14028 | CNGB1 | S958 | Sugiyama | Cyclic nucleotide-gated channel beta-1 (CNG channel beta-1) (Cyclic nucleotide-gated cation channel 4) (CNG channel 4) (CNG-4) (CNG4) (Cyclic nucleotide-gated cation channel gamma) (Cyclic nucleotide-gated cation channel modulatory subunit) (Glutamic acid-rich protein) (GARP) | Pore-forming subunit of the rod cyclic nucleotide-gated channel. Mediates rod photoresponses at dim light converting transient changes in intracellular cGMP levels into electrical signals. In the dark, cGMP levels are high and keep the channel open enabling a steady inward current carried by Na(+) and Ca(2+) ions that leads to membrane depolarization and neurotransmitter release from synaptic terminals. Upon photon absorption cGMP levels decline leading to channel closure and membrane hyperpolarization that ultimately slows neurotransmitter release and signals the presence of light, the end point of the phototransduction cascade (By similarity) (PubMed:34699778). Pore-forming subunit of the olfactory cyclic nucleotide-gated channel. Operates in the cilia of olfactory sensory neurons where chemical stimulation of the odorant is converted to an electrical signal. Mediates odorant-induced cAMP-dependent Ca(2+) influx triggering neuron depolarization. The rise of intracellular Ca(2+) levels potentiates the olfactory response by activating Ca(2+)-dependent Cl(-) channels, but it also serves as a negative feedback signal to desensitize the channel for rapid adaptation to odorants (By similarity). Conducts cGMP- and cAMP-gated ion currents, with permeability for monovalent and divalent cations. The selectivity for Ca(2+) over Na(+) increases with cGMP concentrations, whereas the selectivity among monovalent ions is independent of the cGMP levels (By similarity) (PubMed:34699778). {ECO:0000250|UniProtKB:A0A8I5ZN27, ECO:0000250|UniProtKB:Q28181, ECO:0000250|UniProtKB:Q9NQW8, ECO:0000269|PubMed:34699778}.; FUNCTION: [Isoform GARP2]: High affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties: it is a regulator of spontaneous activation of rod PDE6, thereby serving to lower rod photoreceptor 'dark noise' and allowing these sensory cells to operate at the single photon detection limit. {ECO:0000269|PubMed:16407240}. |
| Q92890 | UFD1 | Y219 | Sugiyama | Ubiquitin recognition factor in ER-associated degradation protein 1 (Ubiquitin fusion degradation protein 1) (UB fusion protein 1) | Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and NPLOC4, which binds to RIGI and recruits RNF125 to promote ubiquitination and degradation of RIGI (PubMed:26471729). {ECO:0000250|UniProtKB:Q9ES53, ECO:0000269|PubMed:26471729}. |
| P42685 | FRK | S324 | Sugiyama | Tyrosine-protein kinase FRK (EC 2.7.10.2) (FYN-related kinase) (Nuclear tyrosine protein kinase RAK) (Protein-tyrosine kinase 5) | Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor. {ECO:0000269|PubMed:19345329}. |
| O60563 | CCNT1 | S433 | Sugiyama | Cyclin-T1 (CycT1) (Cyclin-T) | Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II) (PubMed:16109376, PubMed:16109377, PubMed:30134174, PubMed:35393539). Required to activate the protein kinase activity of CDK9: acts by mediating formation of liquid-liquid phase separation (LLPS) that enhances binding of P-TEFb to the CTD of RNA Pol II (PubMed:29849146, PubMed:35393539). {ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377, ECO:0000269|PubMed:29849146, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:35393539}.; FUNCTION: (Microbial infection) In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes. {ECO:0000269|PubMed:10329125, ECO:0000269|PubMed:10329126}. |
| P51957 | NEK4 | S467 | Sugiyama | Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) | Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage. {ECO:0000250|UniProtKB:Q9Z1J2, ECO:0000269|PubMed:22851694}. |
| Q99961 | SH3GL1 | S64 | Sugiyama | Endophilin-A2 (EEN fusion partner of MLL) (Endophilin-2) (Extra eleven-nineteen leukemia fusion gene protein) (EEN) (SH3 domain protein 2B) (SH3 domain-containing GRB2-like protein 1) | Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity). {ECO:0000250}. |
| P11388 | TOP2A | S390 | Sugiyama | DNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme) | Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (PubMed:17567603, PubMed:18790802, PubMed:22013166, PubMed:22323612). May play a role in regulating the period length of BMAL1 transcriptional oscillation (By similarity). {ECO:0000250|UniProtKB:Q01320, ECO:0000269|PubMed:17567603, ECO:0000269|PubMed:18790802, ECO:0000269|PubMed:22013166, ECO:0000269|PubMed:22323612}. |
| Q13976 | PRKG1 | S73 | Sugiyama | cGMP-dependent protein kinase 1 (cGK 1) (cGK1) (EC 2.7.11.12) (cGMP-dependent protein kinase I) (cGKI) | Serine/threonine protein kinase that acts as a key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-signaling pathway, and other processes involved in several aspects of the CNS like axon guidance, hippocampal and cerebellar learning, circadian rhythm and nociception. Smooth muscle relaxation is mediated through lowering of intracellular free calcium, by desensitization of contractile proteins to calcium, and by decrease in the contractile state of smooth muscle or in platelet activation. Regulates intracellular calcium levels via several pathways: phosphorylates IRAG1 and inhibits IP3-induced Ca(2+) release from intracellular stores, phosphorylation of KCNMA1 (BKCa) channels decreases intracellular Ca(2+) levels, which leads to increased opening of this channel. PRKG1 phosphorylates the canonical transient receptor potential channel (TRPC) family which inactivates the associated inward calcium current. Another mode of action of NO/cGMP/PKGI signaling involves PKGI-mediated inactivation of the Ras homolog gene family member A (RhoA). Phosphorylation of RHOA by PRKG1 blocks the action of this protein in myriad processes: regulation of RHOA translocation; decreasing contraction; controlling vesicle trafficking, reduction of myosin light chain phosphorylation resulting in vasorelaxation. Activation of PRKG1 by NO signaling also alters gene expression in a number of tissues. In smooth muscle cells, increased cGMP and PRKG1 activity influence expression of smooth muscle-specific contractile proteins, levels of proteins in the NO/cGMP signaling pathway, down-regulation of the matrix proteins osteopontin and thrombospondin-1 to limit smooth muscle cell migration and phenotype. Regulates vasodilator-stimulated phosphoprotein (VASP) functions in platelets and smooth muscle. {ECO:0000269|PubMed:10567269, ECO:0000269|PubMed:11162591, ECO:0000269|PubMed:11723116, ECO:0000269|PubMed:12082086, ECO:0000269|PubMed:14608379, ECO:0000269|PubMed:15194681, ECO:0000269|PubMed:16990611, ECO:0000269|PubMed:8182057}. |
| Q04721 | NOTCH2 | S1621 | Sugiyama | Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)] | Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (PubMed:21378985, PubMed:21378989). Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation (PubMed:29149593). Positively regulates self-renewal of liver cancer cells (PubMed:25985737). {ECO:0000250|UniProtKB:O35516, ECO:0000269|PubMed:21378985, ECO:0000269|PubMed:21378989, ECO:0000269|PubMed:25985737, ECO:0000269|PubMed:29149593}. |
| Q15459 | SF3A1 | S465 | Sugiyama | Splicing factor 3A subunit 1 (SF3a120) (Spliceosome-associated protein 114) (SAP 114) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:10882114, PubMed:11533230, PubMed:32494006). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:10882114, PubMed:11533230, PubMed:32494006). Within the 17S U2 SnRNP complex, SF3A1 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex (PubMed:10882114, PubMed:11533230). Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes (PubMed:29360106, PubMed:30315277). {ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:11533230, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:32494006}. |
| O95302 | FKBP9 | S277 | Sugiyama | Peptidyl-prolyl cis-trans isomerase FKBP9 (PPIase FKBP9) (EC 5.2.1.8) (63 kDa FK506-binding protein) (63 kDa FKBP) (FKBP-63) (FK506-binding protein 9) (FKBP-9) (Rotamase) | PPIases accelerate the folding of proteins during protein synthesis. |
| P18124 | RPL7 | S149 | Sugiyama | Large ribosomal subunit protein uL30 (60S ribosomal protein L7) | Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669547). Binds to G-rich structures in 28S rRNA and in mRNAs (PubMed:12962325). Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (PubMed:12962325). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 1.110223e-16 | 15.955 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 1.110223e-16 | 15.955 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 1.110223e-16 | 15.955 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 1.110223e-16 | 15.955 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 1.110223e-16 | 15.955 |
| R-HSA-983189 | Kinesins | 1.110223e-16 | 15.955 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 3.330669e-16 | 15.477 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 7.771561e-16 | 15.109 |
| R-HSA-190861 | Gap junction assembly | 1.443290e-15 | 14.841 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 4.107825e-15 | 14.386 |
| R-HSA-9646399 | Aggrephagy | 7.771561e-15 | 14.109 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 1.421085e-14 | 13.847 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 1.321165e-14 | 13.879 |
| R-HSA-190828 | Gap junction trafficking | 2.775558e-14 | 13.557 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 3.275158e-14 | 13.485 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 5.606626e-14 | 13.251 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 5.517808e-14 | 13.258 |
| R-HSA-437239 | Recycling pathway of L1 | 5.606626e-14 | 13.251 |
| R-HSA-157858 | Gap junction trafficking and regulation | 8.759660e-14 | 13.058 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 1.660894e-13 | 12.780 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 2.265965e-13 | 12.645 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 3.046452e-13 | 12.516 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 4.267697e-13 | 12.370 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 4.676259e-13 | 12.330 |
| R-HSA-391251 | Protein folding | 5.327960e-13 | 12.273 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 7.046586e-13 | 12.152 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 1.153744e-12 | 11.938 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 3.101075e-12 | 11.508 |
| R-HSA-438064 | Post NMDA receptor activation events | 3.626655e-12 | 11.440 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 4.154899e-12 | 11.381 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 6.783352e-12 | 11.169 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 1.498113e-11 | 10.824 |
| R-HSA-9833482 | PKR-mediated signaling | 1.869371e-11 | 10.728 |
| R-HSA-68877 | Mitotic Prometaphase | 2.009859e-11 | 10.697 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 3.044531e-11 | 10.516 |
| R-HSA-2132295 | MHC class II antigen presentation | 3.235590e-11 | 10.490 |
| R-HSA-5620924 | Intraflagellar transport | 3.562850e-11 | 10.448 |
| R-HSA-9663891 | Selective autophagy | 6.106815e-11 | 10.214 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 7.458623e-11 | 10.127 |
| R-HSA-69275 | G2/M Transition | 1.068234e-10 | 9.971 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 1.237247e-10 | 9.908 |
| R-HSA-2467813 | Separation of Sister Chromatids | 1.682031e-10 | 9.774 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 2.891754e-10 | 9.539 |
| R-HSA-68886 | M Phase | 4.624778e-10 | 9.335 |
| R-HSA-68882 | Mitotic Anaphase | 8.831093e-10 | 9.054 |
| R-HSA-69278 | Cell Cycle, Mitotic | 8.842195e-10 | 9.053 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 9.403387e-10 | 9.027 |
| R-HSA-5617833 | Cilium Assembly | 1.203124e-09 | 8.920 |
| R-HSA-373760 | L1CAM interactions | 2.034022e-09 | 8.692 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 3.795727e-09 | 8.421 |
| R-HSA-1640170 | Cell Cycle | 4.203792e-09 | 8.376 |
| R-HSA-9612973 | Autophagy | 7.354648e-09 | 8.133 |
| R-HSA-1632852 | Macroautophagy | 1.989461e-08 | 7.701 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 3.676673e-08 | 7.435 |
| R-HSA-5610787 | Hedgehog 'off' state | 4.007889e-08 | 7.397 |
| R-HSA-9609690 | HCMV Early Events | 9.785598e-08 | 7.009 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 1.361972e-07 | 6.866 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 1.700614e-07 | 6.769 |
| R-HSA-9609646 | HCMV Infection | 2.529642e-07 | 6.597 |
| R-HSA-422475 | Axon guidance | 7.646971e-07 | 6.117 |
| R-HSA-5358351 | Signaling by Hedgehog | 1.057461e-06 | 5.976 |
| R-HSA-9675108 | Nervous system development | 2.066026e-06 | 5.685 |
| R-HSA-199991 | Membrane Trafficking | 2.910887e-06 | 5.536 |
| R-HSA-112315 | Transmission across Chemical Synapses | 4.706418e-06 | 5.327 |
| R-HSA-109582 | Hemostasis | 5.250854e-06 | 5.280 |
| R-HSA-913531 | Interferon Signaling | 7.724961e-06 | 5.112 |
| R-HSA-112316 | Neuronal System | 7.544571e-05 | 4.122 |
| R-HSA-5653656 | Vesicle-mediated transport | 7.602967e-05 | 4.119 |
| R-HSA-162582 | Signal Transduction | 1.067732e-04 | 3.972 |
| R-HSA-2262752 | Cellular responses to stress | 1.129171e-04 | 3.947 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 3.039349e-04 | 3.517 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 4.951746e-04 | 3.305 |
| R-HSA-8953897 | Cellular responses to stimuli | 6.347364e-04 | 3.197 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 1.252592e-03 | 2.902 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 1.390338e-03 | 2.857 |
| R-HSA-74713 | IRS activation | 2.615708e-03 | 2.582 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 3.661521e-03 | 2.436 |
| R-HSA-72649 | Translation initiation complex formation | 4.540580e-03 | 2.343 |
| R-HSA-1280218 | Adaptive Immune System | 4.793143e-03 | 2.319 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 5.072264e-03 | 2.295 |
| R-HSA-193648 | NRAGE signals death through JNK | 5.072264e-03 | 2.295 |
| R-HSA-1266738 | Developmental Biology | 5.231900e-03 | 2.281 |
| R-HSA-9824446 | Viral Infection Pathways | 5.312789e-03 | 2.275 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 5.644170e-03 | 2.248 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 7.258305e-03 | 2.139 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 7.258305e-03 | 2.139 |
| R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 7.424773e-03 | 2.129 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 9.205195e-03 | 2.036 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 9.540274e-03 | 2.020 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 9.540274e-03 | 2.020 |
| R-HSA-74749 | Signal attenuation | 8.653675e-03 | 2.063 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 9.967028e-03 | 2.001 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 1.056328e-02 | 1.976 |
| R-HSA-8853659 | RET signaling | 1.117564e-02 | 1.952 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 1.133942e-02 | 1.945 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 1.133942e-02 | 1.945 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 1.136293e-02 | 1.945 |
| R-HSA-380287 | Centrosome maturation | 1.230121e-02 | 1.910 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 1.283952e-02 | 1.891 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 1.309516e-02 | 1.883 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 1.309516e-02 | 1.883 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 1.331378e-02 | 1.876 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 1.439495e-02 | 1.842 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 1.496177e-02 | 1.825 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 1.602741e-02 | 1.795 |
| R-HSA-416700 | Other semaphorin interactions | 1.773513e-02 | 1.751 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 1.916673e-02 | 1.717 |
| R-HSA-70268 | Pyruvate metabolism | 1.982662e-02 | 1.703 |
| R-HSA-5576891 | Cardiac conduction | 2.101667e-02 | 1.677 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 2.136933e-02 | 1.670 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 2.188982e-02 | 1.660 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 2.260564e-02 | 1.646 |
| R-HSA-392499 | Metabolism of proteins | 2.260889e-02 | 1.646 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 2.329239e-02 | 1.633 |
| R-HSA-381070 | IRE1alpha activates chaperones | 2.333559e-02 | 1.632 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 2.528387e-02 | 1.597 |
| R-HSA-156711 | Polo-like kinase mediated events | 2.528387e-02 | 1.597 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 2.946550e-02 | 1.531 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 3.055017e-02 | 1.515 |
| R-HSA-176034 | Interactions of Tat with host cellular proteins | 3.135819e-02 | 1.504 |
| R-HSA-5578775 | Ion homeostasis | 3.140179e-02 | 1.503 |
| R-HSA-8854521 | Interaction between PHLDA1 and AURKA | 4.159212e-02 | 1.381 |
| R-HSA-429947 | Deadenylation of mRNA | 4.100505e-02 | 1.387 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 3.521942e-02 | 1.453 |
| R-HSA-397014 | Muscle contraction | 3.845459e-02 | 1.415 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 4.066459e-02 | 1.391 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 3.390142e-02 | 1.470 |
| R-HSA-373755 | Semaphorin interactions | 4.066459e-02 | 1.391 |
| R-HSA-5663205 | Infectious disease | 3.968227e-02 | 1.401 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 3.857921e-02 | 1.414 |
| R-HSA-74751 | Insulin receptor signalling cascade | 4.208859e-02 | 1.376 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 4.348688e-02 | 1.362 |
| R-HSA-1266695 | Interleukin-7 signaling | 4.348688e-02 | 1.362 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 4.520402e-02 | 1.345 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 4.602328e-02 | 1.337 |
| R-HSA-1296053 | Classical Kir channels | 5.171856e-02 | 1.286 |
| R-HSA-72766 | Translation | 5.201863e-02 | 1.284 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 5.274473e-02 | 1.278 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 5.274473e-02 | 1.278 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 5.303015e-02 | 1.275 |
| R-HSA-5334118 | DNA methylation | 5.394583e-02 | 1.268 |
| R-HSA-418360 | Platelet calcium homeostasis | 5.394583e-02 | 1.268 |
| R-HSA-4086398 | Ca2+ pathway | 5.600615e-02 | 1.252 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 5.767219e-02 | 1.239 |
| R-HSA-162588 | Budding and maturation of HIV virion | 5.947502e-02 | 1.226 |
| R-HSA-168256 | Immune System | 5.997184e-02 | 1.222 |
| R-HSA-5083630 | Defective LFNG causes SCDO3 | 6.173862e-02 | 1.209 |
| R-HSA-1538133 | G0 and Early G1 | 6.230990e-02 | 1.205 |
| R-HSA-416482 | G alpha (12/13) signalling events | 6.456784e-02 | 1.190 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 6.518991e-02 | 1.186 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 6.634870e-02 | 1.178 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 6.811382e-02 | 1.167 |
| R-HSA-5576894 | Phase 1 - inactivation of fast Na+ channels | 8.146404e-02 | 1.089 |
| R-HSA-9645135 | STAT5 Activation | 9.117159e-02 | 1.040 |
| R-HSA-9027283 | Erythropoietin activates STAT5 | 9.117159e-02 | 1.040 |
| R-HSA-69478 | G2/M DNA replication checkpoint | 9.117159e-02 | 1.040 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 9.117159e-02 | 1.040 |
| R-HSA-1912399 | Pre-NOTCH Processing in the Endoplasmic Reticulum | 1.007771e-01 | 0.997 |
| R-HSA-112412 | SOS-mediated signalling | 1.007771e-01 | 0.997 |
| R-HSA-164843 | 2-LTR circle formation | 1.289924e-01 | 0.889 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 1.289924e-01 | 0.889 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 1.289924e-01 | 0.889 |
| R-HSA-4839744 | Signaling by APC mutants | 1.382005e-01 | 0.859 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 1.382005e-01 | 0.859 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 1.382005e-01 | 0.859 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 1.382005e-01 | 0.859 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 1.473118e-01 | 0.832 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 1.563273e-01 | 0.806 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 1.563273e-01 | 0.806 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 1.563273e-01 | 0.806 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 1.563273e-01 | 0.806 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 1.563273e-01 | 0.806 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 1.563273e-01 | 0.806 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 1.563273e-01 | 0.806 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 1.652481e-01 | 0.782 |
| R-HSA-9027284 | Erythropoietin activates RAS | 1.828093e-01 | 0.738 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 1.828093e-01 | 0.738 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 1.828093e-01 | 0.738 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 1.914516e-01 | 0.718 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 2.000031e-01 | 0.699 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 2.084647e-01 | 0.681 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 2.251218e-01 | 0.648 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 2.251218e-01 | 0.648 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 2.251218e-01 | 0.648 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 2.333192e-01 | 0.632 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.333192e-01 | 0.632 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 2.333192e-01 | 0.632 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.333192e-01 | 0.632 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 2.414304e-01 | 0.617 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 7.943069e-02 | 1.100 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 7.943069e-02 | 1.100 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 9.146373e-02 | 1.039 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 1.042032e-01 | 0.982 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 1.339876e-01 | 0.873 |
| R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 2.414304e-01 | 0.617 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 1.919540e-01 | 0.717 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 2.333192e-01 | 0.632 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 1.872536e-01 | 0.728 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 1.872536e-01 | 0.728 |
| R-HSA-72172 | mRNA Splicing | 2.159226e-01 | 0.666 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 1.153229e-01 | 0.938 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 1.430783e-01 | 0.844 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 1.199176e-01 | 0.921 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 1.872536e-01 | 0.728 |
| R-HSA-198203 | PI3K/AKT activation | 1.289924e-01 | 0.889 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 1.130010e-01 | 0.947 |
| R-HSA-9948299 | Ribosome-associated quality control | 8.433463e-02 | 1.074 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 1.448827e-01 | 0.839 |
| R-HSA-418457 | cGMP effects | 1.740751e-01 | 0.759 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 2.494563e-01 | 0.603 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 1.485336e-01 | 0.828 |
| R-HSA-1483152 | Hydrolysis of LPE | 9.117159e-02 | 1.040 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 2.000031e-01 | 0.699 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 2.573977e-01 | 0.589 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 2.439993e-01 | 0.613 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 9.294089e-02 | 1.032 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 1.792605e-01 | 0.747 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 1.119683e-01 | 0.951 |
| R-HSA-176417 | Phosphorylation of Emi1 | 8.146404e-02 | 1.089 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 1.007771e-01 | 0.997 |
| R-HSA-425986 | Sodium/Proton exchangers | 1.102818e-01 | 0.957 |
| R-HSA-8875656 | MET receptor recycling | 1.102818e-01 | 0.957 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 1.196865e-01 | 0.922 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 1.473118e-01 | 0.832 |
| R-HSA-4839735 | Signaling by AXIN mutants | 1.473118e-01 | 0.832 |
| R-HSA-174490 | Membrane binding and targetting of GAG proteins | 1.652481e-01 | 0.782 |
| R-HSA-5576886 | Phase 4 - resting membrane potential | 1.914516e-01 | 0.718 |
| R-HSA-176412 | Phosphorylation of the APC/C | 1.914516e-01 | 0.718 |
| R-HSA-350054 | Notch-HLH transcription pathway | 2.573977e-01 | 0.589 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 2.652557e-01 | 0.576 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 2.730309e-01 | 0.564 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 1.670520e-01 | 0.777 |
| R-HSA-68875 | Mitotic Prophase | 1.714876e-01 | 0.766 |
| R-HSA-6798695 | Neutrophil degranulation | 2.469114e-01 | 0.607 |
| R-HSA-112399 | IRS-mediated signalling | 1.522032e-01 | 0.818 |
| R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 1.740751e-01 | 0.759 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 9.620659e-02 | 1.017 |
| R-HSA-9682385 | FLT3 signaling in disease | 7.713658e-02 | 1.113 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 2.730309e-01 | 0.564 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 8.133198e-02 | 1.090 |
| R-HSA-74752 | Signaling by Insulin receptor | 9.563416e-02 | 1.019 |
| R-HSA-2428924 | IGF1R signaling cascade | 1.783467e-01 | 0.749 |
| R-HSA-8964046 | VLDL clearance | 1.007771e-01 | 0.997 |
| R-HSA-1483115 | Hydrolysis of LPC | 1.740751e-01 | 0.759 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 2.000031e-01 | 0.699 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 2.168373e-01 | 0.664 |
| R-HSA-2564830 | Cytosolic iron-sulfur cluster assembly | 2.168373e-01 | 0.664 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 1.130010e-01 | 0.947 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 1.821378e-01 | 0.740 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 2.421291e-01 | 0.616 |
| R-HSA-2028269 | Signaling by Hippo | 2.084647e-01 | 0.681 |
| R-HSA-9702518 | STAT5 activation downstream of FLT3 ITD mutants | 2.000031e-01 | 0.699 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 1.708030e-01 | 0.768 |
| R-HSA-9607240 | FLT3 Signaling | 9.294089e-02 | 1.032 |
| R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 | 9.117159e-02 | 1.040 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 1.473118e-01 | 0.832 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 1.828093e-01 | 0.738 |
| R-HSA-2485179 | Activation of the phototransduction cascade | 1.914516e-01 | 0.718 |
| R-HSA-110320 | Translesion Synthesis by POLH | 2.251218e-01 | 0.648 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 2.251218e-01 | 0.648 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 2.494563e-01 | 0.603 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 1.745682e-01 | 0.758 |
| R-HSA-162587 | HIV Life Cycle | 1.172187e-01 | 0.931 |
| R-HSA-162592 | Integration of provirus | 1.473118e-01 | 0.832 |
| R-HSA-69481 | G2/M Checkpoints | 1.925915e-01 | 0.715 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 1.652481e-01 | 0.782 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 1.828093e-01 | 0.738 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 2.333192e-01 | 0.632 |
| R-HSA-73894 | DNA Repair | 2.185721e-01 | 0.660 |
| R-HSA-162906 | HIV Infection | 2.683517e-01 | 0.571 |
| R-HSA-69620 | Cell Cycle Checkpoints | 7.742524e-02 | 1.111 |
| R-HSA-8953854 | Metabolism of RNA | 2.005709e-01 | 0.698 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 1.652481e-01 | 0.782 |
| R-HSA-6807004 | Negative regulation of MET activity | 2.333192e-01 | 0.632 |
| R-HSA-1482922 | Acyl chain remodelling of PI | 2.333192e-01 | 0.632 |
| R-HSA-8964208 | Phenylalanine metabolism | 2.414304e-01 | 0.617 |
| R-HSA-109704 | PI3K Cascade | 1.269363e-01 | 0.896 |
| R-HSA-2672351 | Stimuli-sensing channels | 1.363911e-01 | 0.865 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 2.494563e-01 | 0.603 |
| R-HSA-435368 | Zinc efflux and compartmentalization by the SLC30 family | 7.165341e-02 | 1.145 |
| R-HSA-392517 | Rap1 signalling | 2.251218e-01 | 0.648 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 2.494563e-01 | 0.603 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 2.573977e-01 | 0.589 |
| R-HSA-1226099 | Signaling by FGFR in disease | 2.167197e-01 | 0.664 |
| R-HSA-195721 | Signaling by WNT | 2.503695e-01 | 0.601 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 2.118935e-01 | 0.674 |
| R-HSA-8983711 | OAS antiviral response | 1.563273e-01 | 0.806 |
| R-HSA-418346 | Platelet homeostasis | 1.315991e-01 | 0.881 |
| R-HSA-1433557 | Signaling by SCF-KIT | 1.028342e-01 | 0.988 |
| R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 1.007771e-01 | 0.997 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 1.914516e-01 | 0.718 |
| R-HSA-175474 | Assembly Of The HIV Virion | 2.494563e-01 | 0.603 |
| R-HSA-8983432 | Interleukin-15 signaling | 1.563273e-01 | 0.806 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 2.414304e-01 | 0.617 |
| R-HSA-425410 | Metal ion SLC transporters | 1.199176e-01 | 0.921 |
| R-HSA-2586552 | Signaling by Leptin | 1.289924e-01 | 0.889 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 9.950471e-02 | 1.002 |
| R-HSA-435354 | Zinc transporters | 1.740751e-01 | 0.759 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 2.414304e-01 | 0.617 |
| R-HSA-5669034 | TNFs bind their physiological receptors | 2.730309e-01 | 0.564 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 2.674937e-01 | 0.573 |
| R-HSA-210993 | Tie2 Signaling | 2.168373e-01 | 0.664 |
| R-HSA-1489509 | DAG and IP3 signaling | 1.095834e-01 | 0.960 |
| R-HSA-163685 | Integration of energy metabolism | 8.133198e-02 | 1.090 |
| R-HSA-1643685 | Disease | 1.493965e-01 | 0.826 |
| R-HSA-112043 | PLC beta mediated events | 1.670520e-01 | 0.777 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 2.206021e-01 | 0.656 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 1.485336e-01 | 0.828 |
| R-HSA-6806834 | Signaling by MET | 2.400901e-01 | 0.620 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 2.225821e-01 | 0.653 |
| R-HSA-597592 | Post-translational protein modification | 8.246215e-02 | 1.084 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 2.251218e-01 | 0.648 |
| R-HSA-8964038 | LDL clearance | 2.573977e-01 | 0.589 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 1.558906e-01 | 0.807 |
| R-HSA-112040 | G-protein mediated events | 1.897554e-01 | 0.722 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 1.522032e-01 | 0.818 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 1.339876e-01 | 0.873 |
| R-HSA-9700206 | Signaling by ALK in cancer | 1.339876e-01 | 0.873 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 1.586614e-01 | 0.800 |
| R-HSA-982772 | Growth hormone receptor signaling | 2.652557e-01 | 0.576 |
| R-HSA-194138 | Signaling by VEGF | 1.872536e-01 | 0.728 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 1.199176e-01 | 0.921 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 2.534251e-01 | 0.596 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 1.821378e-01 | 0.740 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 8.585618e-02 | 1.066 |
| R-HSA-9020591 | Interleukin-12 signaling | 2.244902e-01 | 0.649 |
| R-HSA-73887 | Death Receptor Signaling | 1.119683e-01 | 0.951 |
| R-HSA-447115 | Interleukin-12 family signaling | 2.714116e-01 | 0.566 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 2.733659e-01 | 0.563 |
| R-HSA-156902 | Peptide chain elongation | 2.753290e-01 | 0.560 |
| R-HSA-72312 | rRNA processing | 2.800599e-01 | 0.553 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 2.807243e-01 | 0.552 |
| R-HSA-3214842 | HDMs demethylate histones | 2.807243e-01 | 0.552 |
| R-HSA-1296059 | G protein gated Potassium channels | 2.807243e-01 | 0.552 |
| R-HSA-1296041 | Activation of G protein gated Potassium channels | 2.807243e-01 | 0.552 |
| R-HSA-997272 | Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | 2.807243e-01 | 0.552 |
| R-HSA-3295583 | TRP channels | 2.883368e-01 | 0.540 |
| R-HSA-5689901 | Metalloprotease DUBs | 2.883368e-01 | 0.540 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 2.909847e-01 | 0.536 |
| R-HSA-8939211 | ESR-mediated signaling | 2.918485e-01 | 0.535 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 2.948932e-01 | 0.530 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 2.958692e-01 | 0.529 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 2.958692e-01 | 0.529 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 2.958692e-01 | 0.529 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 2.958692e-01 | 0.529 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 2.987987e-01 | 0.525 |
| R-HSA-157118 | Signaling by NOTCH | 2.989548e-01 | 0.524 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 3.009294e-01 | 0.522 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 3.027008e-01 | 0.519 |
| R-HSA-167287 | HIV elongation arrest and recovery | 3.033223e-01 | 0.518 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 3.033223e-01 | 0.518 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 3.065993e-01 | 0.513 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 3.104937e-01 | 0.508 |
| R-HSA-72764 | Eukaryotic Translation Termination | 3.104937e-01 | 0.508 |
| R-HSA-9006335 | Signaling by Erythropoietin | 3.106970e-01 | 0.508 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 3.106970e-01 | 0.508 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 3.106970e-01 | 0.508 |
| R-HSA-392154 | Nitric oxide stimulates guanylate cyclase | 3.106970e-01 | 0.508 |
| R-HSA-9615710 | Late endosomal microautophagy | 3.106970e-01 | 0.508 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 3.106970e-01 | 0.508 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 3.143837e-01 | 0.503 |
| R-HSA-1296071 | Potassium Channels | 3.143837e-01 | 0.503 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 3.143837e-01 | 0.503 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 3.179941e-01 | 0.498 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 3.179941e-01 | 0.498 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 3.182690e-01 | 0.497 |
| R-HSA-422356 | Regulation of insulin secretion | 3.221492e-01 | 0.492 |
| R-HSA-182971 | EGFR downregulation | 3.252144e-01 | 0.488 |
| R-HSA-3214847 | HATs acetylate histones | 3.260240e-01 | 0.487 |
| R-HSA-4791275 | Signaling by WNT in cancer | 3.323587e-01 | 0.478 |
| R-HSA-1296065 | Inwardly rectifying K+ channels | 3.323587e-01 | 0.478 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 3.323587e-01 | 0.478 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 3.323587e-01 | 0.478 |
| R-HSA-2408557 | Selenocysteine synthesis | 3.337562e-01 | 0.477 |
| R-HSA-5688426 | Deubiquitination | 3.347501e-01 | 0.475 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 3.367952e-01 | 0.473 |
| R-HSA-354192 | Integrin signaling | 3.394277e-01 | 0.469 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 3.394277e-01 | 0.469 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 3.394277e-01 | 0.469 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 3.394277e-01 | 0.469 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 3.394277e-01 | 0.469 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 3.403865e-01 | 0.468 |
| R-HSA-192823 | Viral mRNA Translation | 3.414630e-01 | 0.467 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 3.453062e-01 | 0.462 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 3.453062e-01 | 0.462 |
| R-HSA-111885 | Opioid Signalling | 3.453062e-01 | 0.462 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 3.464224e-01 | 0.460 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 3.464224e-01 | 0.460 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 3.464224e-01 | 0.460 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 3.491422e-01 | 0.457 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 3.491422e-01 | 0.457 |
| R-HSA-5696400 | Dual Incision in GG-NER | 3.533434e-01 | 0.452 |
| R-HSA-1980145 | Signaling by NOTCH2 | 3.533434e-01 | 0.452 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 3.533434e-01 | 0.452 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 3.533434e-01 | 0.452 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 3.533434e-01 | 0.452 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 3.533434e-01 | 0.452 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 3.533434e-01 | 0.452 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 3.533434e-01 | 0.452 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 3.533434e-01 | 0.452 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 3.533434e-01 | 0.452 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 3.601916e-01 | 0.443 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 3.601916e-01 | 0.443 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 3.601916e-01 | 0.443 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 3.601916e-01 | 0.443 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 3.601916e-01 | 0.443 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 3.606771e-01 | 0.443 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 3.669676e-01 | 0.435 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 3.669676e-01 | 0.435 |
| R-HSA-74158 | RNA Polymerase III Transcription | 3.669676e-01 | 0.435 |
| R-HSA-1296072 | Voltage gated Potassium channels | 3.736724e-01 | 0.428 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 3.736724e-01 | 0.428 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 3.736724e-01 | 0.428 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 3.736724e-01 | 0.428 |
| R-HSA-8963691 | Phenylalanine and tyrosine metabolism | 3.736724e-01 | 0.428 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 3.736724e-01 | 0.428 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 3.736724e-01 | 0.428 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 3.795393e-01 | 0.421 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 3.795393e-01 | 0.421 |
| R-HSA-983712 | Ion channel transport | 3.800012e-01 | 0.420 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 3.803065e-01 | 0.420 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 3.868707e-01 | 0.412 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 3.868707e-01 | 0.412 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 3.868707e-01 | 0.412 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 3.870487e-01 | 0.412 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 3.922994e-01 | 0.406 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 3.933658e-01 | 0.405 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 3.933658e-01 | 0.405 |
| R-HSA-167169 | HIV Transcription Elongation | 3.933658e-01 | 0.405 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 3.933658e-01 | 0.405 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 3.933658e-01 | 0.405 |
| R-HSA-451927 | Interleukin-2 family signaling | 3.933658e-01 | 0.405 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 3.982382e-01 | 0.400 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 3.982382e-01 | 0.400 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 3.997925e-01 | 0.398 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 3.997925e-01 | 0.398 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 3.997925e-01 | 0.398 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 3.997925e-01 | 0.398 |
| R-HSA-5674135 | MAP2K and MAPK activation | 4.061515e-01 | 0.391 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 4.061515e-01 | 0.391 |
| R-HSA-5693538 | Homology Directed Repair | 4.093332e-01 | 0.388 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 4.093332e-01 | 0.388 |
| R-HSA-991365 | Activation of GABAB receptors | 4.124436e-01 | 0.385 |
| R-HSA-977444 | GABA B receptor activation | 4.124436e-01 | 0.385 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 4.124436e-01 | 0.385 |
| R-HSA-73928 | Depyrimidination | 4.124436e-01 | 0.385 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 4.124436e-01 | 0.385 |
| R-HSA-9710421 | Defective pyroptosis | 4.186693e-01 | 0.378 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 4.186693e-01 | 0.378 |
| R-HSA-8854214 | TBC/RABGAPs | 4.186693e-01 | 0.378 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 4.197868e-01 | 0.377 |
| R-HSA-3214858 | RMTs methylate histone arginines | 4.248295e-01 | 0.372 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 4.276012e-01 | 0.369 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 4.309248e-01 | 0.366 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 4.369558e-01 | 0.360 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 4.369558e-01 | 0.360 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 4.369558e-01 | 0.360 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 4.369558e-01 | 0.360 |
| R-HSA-6802949 | Signaling by RAS mutants | 4.369558e-01 | 0.360 |
| R-HSA-9675135 | Diseases of DNA repair | 4.369558e-01 | 0.360 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 4.369558e-01 | 0.360 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 4.369558e-01 | 0.360 |
| R-HSA-75153 | Apoptotic execution phase | 4.369558e-01 | 0.360 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 4.420024e-01 | 0.355 |
| R-HSA-70263 | Gluconeogenesis | 4.488279e-01 | 0.348 |
| R-HSA-73893 | DNA Damage Bypass | 4.546703e-01 | 0.342 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 4.562036e-01 | 0.341 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 4.604511e-01 | 0.337 |
| R-HSA-9843745 | Adipogenesis | 4.632266e-01 | 0.334 |
| R-HSA-2514856 | The phototransduction cascade | 4.661710e-01 | 0.331 |
| R-HSA-912446 | Meiotic recombination | 4.661710e-01 | 0.331 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 4.718307e-01 | 0.326 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 4.718307e-01 | 0.326 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 4.718307e-01 | 0.326 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 4.718307e-01 | 0.326 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 4.774306e-01 | 0.321 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 4.774306e-01 | 0.321 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 4.774306e-01 | 0.321 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 4.774306e-01 | 0.321 |
| R-HSA-445355 | Smooth Muscle Contraction | 4.774306e-01 | 0.321 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 4.774306e-01 | 0.321 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 4.774306e-01 | 0.321 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 4.829715e-01 | 0.316 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 4.829715e-01 | 0.316 |
| R-HSA-3214815 | HDACs deacetylate histones | 4.884541e-01 | 0.311 |
| R-HSA-177929 | Signaling by EGFR | 4.938788e-01 | 0.306 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 4.992463e-01 | 0.302 |
| R-HSA-6782135 | Dual incision in TC-NER | 5.045572e-01 | 0.297 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 5.045572e-01 | 0.297 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 5.098121e-01 | 0.293 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 5.108581e-01 | 0.292 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 5.150117e-01 | 0.288 |
| R-HSA-8873719 | RAB geranylgeranylation | 5.150117e-01 | 0.288 |
| R-HSA-977443 | GABA receptor activation | 5.150117e-01 | 0.288 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 5.150117e-01 | 0.288 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 5.252468e-01 | 0.280 |
| R-HSA-9707616 | Heme signaling | 5.252468e-01 | 0.280 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 5.252468e-01 | 0.280 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 5.336222e-01 | 0.273 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 5.352671e-01 | 0.271 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 5.399930e-01 | 0.268 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 5.401981e-01 | 0.267 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 5.450772e-01 | 0.264 |
| R-HSA-5683057 | MAPK family signaling cascades | 5.482704e-01 | 0.261 |
| R-HSA-1989781 | PPARA activates gene expression | 5.494368e-01 | 0.260 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 5.494368e-01 | 0.260 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 5.499047e-01 | 0.260 |
| R-HSA-5693606 | DNA Double Strand Break Response | 5.499047e-01 | 0.260 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 5.546813e-01 | 0.256 |
| R-HSA-167172 | Transcription of the HIV genome | 5.546813e-01 | 0.256 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 5.556572e-01 | 0.255 |
| R-HSA-9610379 | HCMV Late Events | 5.556572e-01 | 0.255 |
| R-HSA-9711097 | Cellular response to starvation | 5.587447e-01 | 0.253 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 5.587447e-01 | 0.253 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 5.640839e-01 | 0.249 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 5.640839e-01 | 0.249 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 5.640839e-01 | 0.249 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 5.640839e-01 | 0.249 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 5.640839e-01 | 0.249 |
| R-HSA-9006936 | Signaling by TGFB family members | 5.648741e-01 | 0.248 |
| R-HSA-5633007 | Regulation of TP53 Activity | 5.648741e-01 | 0.248 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 5.687109e-01 | 0.245 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 5.687109e-01 | 0.245 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 5.687109e-01 | 0.245 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 5.732890e-01 | 0.242 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 5.732890e-01 | 0.242 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 5.732890e-01 | 0.242 |
| R-HSA-2408522 | Selenoamino acid metabolism | 5.769501e-01 | 0.239 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 5.823009e-01 | 0.235 |
| R-HSA-9013694 | Signaling by NOTCH4 | 5.823009e-01 | 0.235 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 5.867357e-01 | 0.232 |
| R-HSA-8852135 | Protein ubiquitination | 5.867357e-01 | 0.232 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 5.911236e-01 | 0.228 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 5.997610e-01 | 0.222 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 5.997610e-01 | 0.222 |
| R-HSA-73864 | RNA Polymerase I Transcription | 5.997610e-01 | 0.222 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 6.003670e-01 | 0.222 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 6.040114e-01 | 0.219 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 6.058073e-01 | 0.218 |
| R-HSA-5689880 | Ub-specific processing proteases | 6.060677e-01 | 0.217 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 6.060677e-01 | 0.217 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 6.060677e-01 | 0.217 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 6.082169e-01 | 0.216 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 6.082169e-01 | 0.216 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 6.123781e-01 | 0.213 |
| R-HSA-977225 | Amyloid fiber formation | 6.123781e-01 | 0.213 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 6.164953e-01 | 0.210 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 6.205690e-01 | 0.207 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 6.205690e-01 | 0.207 |
| R-HSA-9658195 | Leishmania infection | 6.216960e-01 | 0.206 |
| R-HSA-9824443 | Parasitic Infection Pathways | 6.216960e-01 | 0.206 |
| R-HSA-168255 | Influenza Infection | 6.228019e-01 | 0.206 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 6.245997e-01 | 0.204 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 6.245997e-01 | 0.204 |
| R-HSA-2559583 | Cellular Senescence | 6.255374e-01 | 0.204 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 6.285878e-01 | 0.202 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 6.285878e-01 | 0.202 |
| R-HSA-1500620 | Meiosis | 6.285878e-01 | 0.202 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 6.336521e-01 | 0.198 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 6.364381e-01 | 0.196 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 6.393189e-01 | 0.194 |
| R-HSA-9645723 | Diseases of programmed cell death | 6.441235e-01 | 0.191 |
| R-HSA-73884 | Base Excision Repair | 6.516473e-01 | 0.186 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 6.521575e-01 | 0.186 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 6.542656e-01 | 0.184 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 6.626375e-01 | 0.179 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 6.662237e-01 | 0.176 |
| R-HSA-5389840 | Mitochondrial translation elongation | 6.801937e-01 | 0.167 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 6.801937e-01 | 0.167 |
| R-HSA-376176 | Signaling by ROBO receptors | 6.842805e-01 | 0.165 |
| R-HSA-5368286 | Mitochondrial translation initiation | 6.869591e-01 | 0.163 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 7.000660e-01 | 0.155 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 7.000660e-01 | 0.155 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 7.032566e-01 | 0.153 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 7.064134e-01 | 0.151 |
| R-HSA-9833110 | RSV-host interactions | 7.095368e-01 | 0.149 |
| R-HSA-8957322 | Metabolism of steroids | 7.096079e-01 | 0.149 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 7.096161e-01 | 0.149 |
| R-HSA-5696398 | Nucleotide Excision Repair | 7.126272e-01 | 0.147 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 7.156849e-01 | 0.145 |
| R-HSA-211000 | Gene Silencing by RNA | 7.187102e-01 | 0.143 |
| R-HSA-5419276 | Mitochondrial translation termination | 7.246653e-01 | 0.140 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 7.246653e-01 | 0.140 |
| R-HSA-8951664 | Neddylation | 7.269640e-01 | 0.138 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 7.390101e-01 | 0.131 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 7.445378e-01 | 0.128 |
| R-HSA-909733 | Interferon alpha/beta signaling | 7.472578e-01 | 0.127 |
| R-HSA-9007101 | Rab regulation of trafficking | 7.526118e-01 | 0.123 |
| R-HSA-1592230 | Mitochondrial biogenesis | 7.526118e-01 | 0.123 |
| R-HSA-70326 | Glucose metabolism | 7.526118e-01 | 0.123 |
| R-HSA-3247509 | Chromatin modifying enzymes | 7.532906e-01 | 0.123 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 7.578530e-01 | 0.120 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 7.611820e-01 | 0.119 |
| R-HSA-9717207 | Sensory perception of sweet, bitter, and umami (glutamate) taste | 7.680065e-01 | 0.115 |
| R-HSA-6809371 | Formation of the cornified envelope | 7.704781e-01 | 0.113 |
| R-HSA-162909 | Host Interactions of HIV factors | 7.704781e-01 | 0.113 |
| R-HSA-69206 | G1/S Transition | 7.753429e-01 | 0.111 |
| R-HSA-168249 | Innate Immune System | 7.786905e-01 | 0.109 |
| R-HSA-114608 | Platelet degranulation | 7.801051e-01 | 0.108 |
| R-HSA-4839726 | Chromatin organization | 7.809377e-01 | 0.107 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 7.824485e-01 | 0.107 |
| R-HSA-1474165 | Reproduction | 7.893307e-01 | 0.103 |
| R-HSA-9717189 | Sensory perception of taste | 7.915763e-01 | 0.102 |
| R-HSA-9909396 | Circadian clock | 7.937981e-01 | 0.100 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 7.959964e-01 | 0.099 |
| R-HSA-416476 | G alpha (q) signalling events | 8.058470e-01 | 0.094 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 8.066431e-01 | 0.093 |
| R-HSA-5368287 | Mitochondrial translation | 8.087052e-01 | 0.092 |
| R-HSA-6807070 | PTEN Regulation | 8.107454e-01 | 0.091 |
| R-HSA-9711123 | Cellular response to chemical stress | 8.120528e-01 | 0.090 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 8.127640e-01 | 0.090 |
| R-HSA-9664417 | Leishmania phagocytosis | 8.127640e-01 | 0.090 |
| R-HSA-9664407 | Parasite infection | 8.127640e-01 | 0.090 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 8.147612e-01 | 0.089 |
| R-HSA-449147 | Signaling by Interleukins | 8.194852e-01 | 0.086 |
| R-HSA-2187338 | Visual phototransduction | 8.281609e-01 | 0.082 |
| R-HSA-166520 | Signaling by NTRKs | 8.299948e-01 | 0.081 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 8.324082e-01 | 0.080 |
| R-HSA-9679191 | Potential therapeutics for SARS | 8.336043e-01 | 0.079 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 8.353805e-01 | 0.078 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 8.371377e-01 | 0.077 |
| R-HSA-69306 | DNA Replication | 8.388763e-01 | 0.076 |
| R-HSA-109581 | Apoptosis | 8.537165e-01 | 0.069 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 8.700207e-01 | 0.060 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 8.714101e-01 | 0.060 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 8.714101e-01 | 0.060 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 8.741448e-01 | 0.058 |
| R-HSA-3781865 | Diseases of glycosylation | 8.857525e-01 | 0.053 |
| R-HSA-168898 | Toll-like Receptor Cascades | 8.940394e-01 | 0.049 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 8.995900e-01 | 0.046 |
| R-HSA-389948 | Co-inhibition by PD-1 | 9.038216e-01 | 0.044 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 9.068785e-01 | 0.042 |
| R-HSA-5357801 | Programmed Cell Death | 9.098388e-01 | 0.041 |
| R-HSA-6805567 | Keratinization | 9.108046e-01 | 0.041 |
| R-HSA-418990 | Adherens junctions interactions | 9.216225e-01 | 0.035 |
| R-HSA-388396 | GPCR downstream signalling | 9.280670e-01 | 0.032 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 9.280992e-01 | 0.032 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 9.296334e-01 | 0.032 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 9.299375e-01 | 0.032 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.311351e-01 | 0.031 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.361444e-01 | 0.029 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.381073e-01 | 0.028 |
| R-HSA-418594 | G alpha (i) signalling events | 9.433835e-01 | 0.025 |
| R-HSA-421270 | Cell-cell junction organization | 9.451019e-01 | 0.025 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 9.479885e-01 | 0.023 |
| R-HSA-9734767 | Developmental Cell Lineages | 9.517779e-01 | 0.021 |
| R-HSA-382551 | Transport of small molecules | 9.583356e-01 | 0.018 |
| R-HSA-446728 | Cell junction organization | 9.589987e-01 | 0.018 |
| R-HSA-372790 | Signaling by GPCR | 9.590829e-01 | 0.018 |
| R-HSA-1483257 | Phospholipid metabolism | 9.658905e-01 | 0.015 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.676434e-01 | 0.014 |
| R-HSA-1500931 | Cell-Cell communication | 9.728338e-01 | 0.012 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 9.810140e-01 | 0.008 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.838713e-01 | 0.007 |
| R-HSA-9679506 | SARS-CoV Infections | 9.855185e-01 | 0.006 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.879794e-01 | 0.005 |
| R-HSA-8978868 | Fatty acid metabolism | 9.900131e-01 | 0.004 |
| R-HSA-74160 | Gene expression (Transcription) | 9.915933e-01 | 0.004 |
| R-HSA-5668914 | Diseases of metabolism | 9.919719e-01 | 0.004 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.940889e-01 | 0.003 |
| R-HSA-212436 | Generic Transcription Pathway | 9.952406e-01 | 0.002 |
| R-HSA-73857 | RNA Polymerase II Transcription | 9.983378e-01 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 9.997531e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.998909e-01 | 0.000 |
| R-HSA-381753 | Olfactory Signaling Pathway | 9.999380e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999994e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
MARK3 |
0.781 | 0.513 | 4 | 0.554 |
MARK4 |
0.780 | 0.477 | 4 | 0.446 |
MARK2 |
0.779 | 0.505 | 4 | 0.532 |
QSK |
0.778 | 0.438 | 4 | 0.483 |
SIK |
0.771 | 0.362 | -3 | 0.778 |
AMPKA1 |
0.769 | 0.292 | -3 | 0.867 |
COT |
0.769 | 0.071 | 2 | 0.799 |
MARK1 |
0.768 | 0.434 | 4 | 0.498 |
QIK |
0.767 | 0.345 | -3 | 0.829 |
AMPKA2 |
0.763 | 0.246 | -3 | 0.845 |
NUAK2 |
0.762 | 0.182 | -3 | 0.845 |
MST4 |
0.761 | 0.129 | 2 | 0.840 |
MOS |
0.760 | 0.078 | 1 | 0.876 |
NIM1 |
0.759 | 0.254 | 3 | 0.768 |
TSSK1 |
0.759 | 0.215 | -3 | 0.874 |
WNK1 |
0.759 | 0.116 | -2 | 0.796 |
MTOR |
0.758 | 0.114 | 1 | 0.824 |
PKN3 |
0.758 | 0.102 | -3 | 0.840 |
GRK1 |
0.756 | 0.073 | -2 | 0.880 |
CDKL1 |
0.756 | 0.086 | -3 | 0.818 |
CDC7 |
0.756 | 0.011 | 1 | 0.840 |
PRPK |
0.754 | -0.023 | -1 | 0.648 |
NUAK1 |
0.754 | 0.174 | -3 | 0.812 |
PKN2 |
0.754 | 0.100 | -3 | 0.858 |
RAF1 |
0.754 | 0.033 | 1 | 0.860 |
CAMK1B |
0.754 | 0.065 | -3 | 0.863 |
NDR2 |
0.754 | 0.045 | -3 | 0.855 |
HUNK |
0.753 | 0.095 | 2 | 0.716 |
BRSK2 |
0.752 | 0.220 | -3 | 0.832 |
NLK |
0.752 | 0.042 | 1 | 0.827 |
CDKL5 |
0.752 | 0.072 | -3 | 0.815 |
PIM3 |
0.752 | 0.024 | -3 | 0.847 |
PKCD |
0.752 | 0.107 | 2 | 0.799 |
GCN2 |
0.751 | -0.003 | 2 | 0.780 |
BRSK1 |
0.751 | 0.193 | -3 | 0.807 |
NDR1 |
0.750 | 0.049 | -3 | 0.856 |
WNK3 |
0.750 | 0.043 | 1 | 0.856 |
NIK |
0.749 | 0.094 | -3 | 0.876 |
CAMK2G |
0.749 | -0.029 | 2 | 0.714 |
TSSK2 |
0.749 | 0.137 | -5 | 0.766 |
SSTK |
0.749 | 0.255 | 4 | 0.414 |
MELK |
0.748 | 0.129 | -3 | 0.828 |
ULK2 |
0.748 | -0.033 | 2 | 0.750 |
MLK1 |
0.747 | 0.022 | 2 | 0.816 |
TBK1 |
0.747 | -0.015 | 1 | 0.768 |
RIPK3 |
0.746 | -0.002 | 3 | 0.717 |
DSTYK |
0.746 | -0.012 | 2 | 0.818 |
SKMLCK |
0.746 | 0.042 | -2 | 0.786 |
PKCA |
0.746 | 0.115 | 2 | 0.782 |
ATR |
0.746 | 0.016 | 1 | 0.871 |
ERK5 |
0.746 | 0.021 | 1 | 0.811 |
IKKB |
0.745 | -0.077 | -2 | 0.728 |
PKCB |
0.745 | 0.108 | 2 | 0.786 |
GRK7 |
0.745 | 0.110 | 1 | 0.840 |
SGK3 |
0.745 | 0.103 | -3 | 0.801 |
PDHK4 |
0.744 | -0.097 | 1 | 0.878 |
IRE1 |
0.744 | 0.027 | 1 | 0.842 |
PKCG |
0.744 | 0.089 | 2 | 0.768 |
PKACG |
0.744 | 0.033 | -2 | 0.677 |
PIM1 |
0.744 | 0.043 | -3 | 0.816 |
CAMLCK |
0.744 | 0.021 | -2 | 0.766 |
BCKDK |
0.743 | -0.039 | -1 | 0.609 |
BMPR2 |
0.743 | -0.112 | -2 | 0.807 |
RSK2 |
0.743 | 0.026 | -3 | 0.791 |
DAPK2 |
0.742 | 0.016 | -3 | 0.860 |
RSK3 |
0.742 | 0.032 | -3 | 0.778 |
P70S6KB |
0.742 | 0.014 | -3 | 0.817 |
NEK6 |
0.742 | -0.046 | -2 | 0.764 |
NEK7 |
0.741 | -0.042 | -3 | 0.802 |
PDHK1 |
0.741 | -0.096 | 1 | 0.855 |
TGFBR2 |
0.741 | -0.022 | -2 | 0.737 |
CAMK1G |
0.741 | 0.115 | -3 | 0.779 |
GRK5 |
0.741 | -0.081 | -3 | 0.838 |
IKKE |
0.740 | -0.060 | 1 | 0.754 |
P90RSK |
0.739 | 0.016 | -3 | 0.790 |
HIPK4 |
0.739 | 0.055 | 1 | 0.792 |
MASTL |
0.739 | -0.029 | -2 | 0.767 |
RIPK1 |
0.739 | -0.021 | 1 | 0.880 |
GRK6 |
0.739 | -0.042 | 1 | 0.875 |
CAMK4 |
0.739 | 0.021 | -3 | 0.834 |
PKCH |
0.739 | 0.074 | 2 | 0.767 |
ANKRD3 |
0.738 | 0.003 | 1 | 0.899 |
ICK |
0.738 | 0.022 | -3 | 0.846 |
PKCZ |
0.738 | 0.066 | 2 | 0.811 |
MAPKAPK3 |
0.738 | 0.004 | -3 | 0.808 |
PHKG1 |
0.737 | 0.067 | -3 | 0.839 |
MLK2 |
0.737 | -0.023 | 2 | 0.792 |
AURC |
0.737 | 0.018 | -2 | 0.588 |
LATS2 |
0.736 | -0.019 | -5 | 0.685 |
CAMK2D |
0.736 | -0.032 | -3 | 0.847 |
ATM |
0.736 | 0.015 | 1 | 0.816 |
NEK9 |
0.736 | -0.026 | 2 | 0.831 |
TTBK2 |
0.735 | -0.028 | 2 | 0.654 |
CLK3 |
0.735 | -0.009 | 1 | 0.826 |
CAMK2B |
0.735 | -0.017 | 2 | 0.672 |
IRE2 |
0.735 | 0.021 | 2 | 0.767 |
MLK3 |
0.735 | 0.008 | 2 | 0.772 |
MNK2 |
0.735 | 0.014 | -2 | 0.683 |
PRKD2 |
0.734 | -0.000 | -3 | 0.800 |
WNK4 |
0.734 | 0.057 | -2 | 0.786 |
PKR |
0.734 | 0.020 | 1 | 0.876 |
PRKD1 |
0.734 | -0.035 | -3 | 0.836 |
ULK1 |
0.734 | -0.094 | -3 | 0.796 |
GSK3B |
0.734 | -0.051 | 4 | 0.054 |
MAPKAPK2 |
0.733 | 0.009 | -3 | 0.775 |
MYLK4 |
0.733 | 0.032 | -2 | 0.707 |
MPSK1 |
0.733 | 0.134 | 1 | 0.825 |
NEK2 |
0.733 | 0.044 | 2 | 0.831 |
GSK3A |
0.732 | -0.027 | 4 | 0.051 |
IKKA |
0.732 | -0.064 | -2 | 0.713 |
SNRK |
0.732 | 0.046 | 2 | 0.628 |
RSK4 |
0.732 | 0.025 | -3 | 0.765 |
GRK4 |
0.732 | -0.048 | -2 | 0.842 |
TGFBR1 |
0.732 | 0.005 | -2 | 0.760 |
DLK |
0.732 | -0.110 | 1 | 0.862 |
LATS1 |
0.732 | -0.003 | -3 | 0.852 |
PAK1 |
0.731 | -0.014 | -2 | 0.699 |
MST3 |
0.731 | 0.120 | 2 | 0.827 |
AURB |
0.731 | 0.014 | -2 | 0.584 |
PKACB |
0.731 | 0.037 | -2 | 0.596 |
CHAK2 |
0.731 | -0.093 | -1 | 0.588 |
PKCT |
0.731 | 0.073 | 2 | 0.771 |
MNK1 |
0.731 | 0.023 | -2 | 0.697 |
PKG2 |
0.731 | 0.016 | -2 | 0.601 |
KIS |
0.731 | 0.030 | 1 | 0.665 |
CAMK2A |
0.730 | -0.020 | 2 | 0.696 |
SRPK1 |
0.730 | 0.011 | -3 | 0.775 |
PLK4 |
0.730 | 0.045 | 2 | 0.569 |
ALK4 |
0.730 | -0.030 | -2 | 0.783 |
BMPR1B |
0.729 | 0.022 | 1 | 0.793 |
PRKD3 |
0.729 | 0.013 | -3 | 0.759 |
FAM20C |
0.729 | -0.017 | 2 | 0.450 |
MSK2 |
0.729 | -0.006 | -3 | 0.768 |
PLK1 |
0.729 | -0.065 | -2 | 0.703 |
PAK3 |
0.728 | -0.028 | -2 | 0.695 |
ERK7 |
0.728 | 0.158 | 2 | 0.759 |
IRAK4 |
0.728 | 0.014 | 1 | 0.852 |
HIPK1 |
0.728 | 0.053 | 1 | 0.710 |
PIM2 |
0.728 | 0.043 | -3 | 0.774 |
PRKX |
0.728 | 0.039 | -3 | 0.720 |
MEK1 |
0.728 | -0.021 | 2 | 0.741 |
DCAMKL1 |
0.728 | 0.063 | -3 | 0.802 |
DNAPK |
0.728 | 0.038 | 1 | 0.754 |
YSK4 |
0.727 | -0.015 | 1 | 0.797 |
MLK4 |
0.727 | -0.020 | 2 | 0.754 |
CDK7 |
0.727 | -0.008 | 1 | 0.643 |
AKT2 |
0.727 | 0.036 | -3 | 0.718 |
PAK2 |
0.726 | -0.017 | -2 | 0.692 |
PHKG2 |
0.726 | 0.052 | -3 | 0.811 |
AKT1 |
0.726 | 0.057 | -3 | 0.740 |
PKCI |
0.726 | 0.078 | 2 | 0.809 |
VRK2 |
0.725 | -0.086 | 1 | 0.894 |
CDK18 |
0.725 | 0.022 | 1 | 0.585 |
MSK1 |
0.725 | -0.007 | -3 | 0.780 |
CDK5 |
0.724 | 0.022 | 1 | 0.670 |
CHAK1 |
0.724 | -0.057 | 2 | 0.726 |
DRAK1 |
0.724 | -0.013 | 1 | 0.845 |
PKCE |
0.724 | 0.080 | 2 | 0.768 |
CDK8 |
0.724 | -0.010 | 1 | 0.632 |
SRPK3 |
0.723 | 0.008 | -3 | 0.744 |
MEKK3 |
0.723 | -0.006 | 1 | 0.831 |
MEKK1 |
0.723 | 0.020 | 1 | 0.832 |
ALK2 |
0.722 | -0.026 | -2 | 0.787 |
CDK2 |
0.722 | 0.020 | 1 | 0.719 |
TAO3 |
0.722 | 0.060 | 1 | 0.824 |
ZAK |
0.722 | -0.018 | 1 | 0.808 |
PERK |
0.721 | -0.043 | -2 | 0.791 |
DYRK2 |
0.721 | -0.002 | 1 | 0.691 |
MEKK2 |
0.721 | 0.029 | 2 | 0.775 |
CHK1 |
0.721 | -0.001 | -3 | 0.840 |
P38A |
0.721 | 0.014 | 1 | 0.690 |
CK1E |
0.721 | 0.036 | -3 | 0.518 |
SRPK2 |
0.721 | 0.009 | -3 | 0.707 |
CAMK1D |
0.721 | 0.058 | -3 | 0.718 |
BRAF |
0.721 | -0.036 | -4 | 0.770 |
ACVR2A |
0.720 | -0.042 | -2 | 0.725 |
PKACA |
0.720 | 0.031 | -2 | 0.550 |
CLK4 |
0.720 | 0.004 | -3 | 0.786 |
CAMK1A |
0.720 | 0.099 | -3 | 0.698 |
MEK5 |
0.720 | -0.046 | 2 | 0.764 |
CLK1 |
0.720 | 0.021 | -3 | 0.767 |
SMG1 |
0.720 | -0.043 | 1 | 0.825 |
SMMLCK |
0.720 | 0.010 | -3 | 0.831 |
GAK |
0.720 | 0.069 | 1 | 0.884 |
GRK2 |
0.719 | -0.023 | -2 | 0.734 |
P70S6K |
0.719 | 0.007 | -3 | 0.740 |
PKN1 |
0.719 | 0.076 | -3 | 0.751 |
HRI |
0.719 | -0.064 | -2 | 0.768 |
HIPK2 |
0.719 | 0.023 | 1 | 0.593 |
PLK3 |
0.719 | -0.041 | 2 | 0.645 |
PAK6 |
0.719 | -0.035 | -2 | 0.630 |
NEK5 |
0.719 | 0.013 | 1 | 0.879 |
CDK14 |
0.719 | 0.029 | 1 | 0.634 |
ACVR2B |
0.719 | -0.042 | -2 | 0.742 |
NEK11 |
0.718 | 0.031 | 1 | 0.830 |
CDK17 |
0.718 | 0.013 | 1 | 0.530 |
CDK19 |
0.717 | -0.007 | 1 | 0.590 |
HIPK3 |
0.717 | 0.014 | 1 | 0.706 |
DYRK1A |
0.717 | 0.013 | 1 | 0.724 |
DCAMKL2 |
0.717 | 0.026 | -3 | 0.816 |
JNK3 |
0.717 | -0.004 | 1 | 0.634 |
ERK1 |
0.716 | 0.003 | 1 | 0.602 |
AKT3 |
0.716 | 0.052 | -3 | 0.669 |
TAO2 |
0.716 | 0.039 | 2 | 0.829 |
SGK1 |
0.716 | 0.060 | -3 | 0.658 |
CDK10 |
0.716 | 0.033 | 1 | 0.618 |
NEK8 |
0.716 | 0.015 | 2 | 0.813 |
PDK1 |
0.715 | 0.060 | 1 | 0.881 |
ERK2 |
0.715 | -0.016 | 1 | 0.659 |
JNK2 |
0.715 | -0.002 | 1 | 0.586 |
CDK16 |
0.715 | 0.030 | 1 | 0.553 |
CDK9 |
0.715 | -0.014 | 1 | 0.632 |
P38B |
0.715 | 0.007 | 1 | 0.616 |
CDK1 |
0.714 | -0.006 | 1 | 0.611 |
DAPK3 |
0.714 | 0.021 | -3 | 0.814 |
TLK2 |
0.713 | -0.095 | 1 | 0.825 |
P38G |
0.713 | 0.009 | 1 | 0.517 |
CDK13 |
0.713 | -0.030 | 1 | 0.622 |
CK2A2 |
0.713 | 0.040 | 1 | 0.697 |
MEKK6 |
0.713 | 0.058 | 1 | 0.808 |
MAP3K15 |
0.712 | 0.085 | 1 | 0.802 |
PASK |
0.712 | -0.041 | -3 | 0.848 |
MAPKAPK5 |
0.712 | -0.067 | -3 | 0.744 |
AURA |
0.712 | -0.033 | -2 | 0.561 |
CK1D |
0.711 | 0.032 | -3 | 0.477 |
IRAK1 |
0.711 | -0.080 | -1 | 0.532 |
TLK1 |
0.711 | -0.062 | -2 | 0.781 |
ROCK2 |
0.711 | 0.062 | -3 | 0.820 |
CLK2 |
0.711 | 0.014 | -3 | 0.772 |
CDK12 |
0.710 | -0.018 | 1 | 0.593 |
LRRK2 |
0.710 | 0.043 | 2 | 0.827 |
BMPR1A |
0.710 | -0.021 | 1 | 0.768 |
EEF2K |
0.709 | 0.009 | 3 | 0.766 |
GCK |
0.709 | 0.055 | 1 | 0.813 |
PRP4 |
0.709 | -0.018 | -3 | 0.770 |
DYRK1B |
0.709 | 0.011 | 1 | 0.640 |
CK1A2 |
0.709 | 0.019 | -3 | 0.476 |
HPK1 |
0.709 | 0.071 | 1 | 0.798 |
NEK4 |
0.709 | 0.023 | 1 | 0.821 |
MST2 |
0.709 | 0.027 | 1 | 0.820 |
MRCKB |
0.709 | 0.036 | -3 | 0.773 |
MINK |
0.709 | 0.043 | 1 | 0.809 |
YSK1 |
0.708 | 0.091 | 2 | 0.833 |
TTBK1 |
0.708 | -0.067 | 2 | 0.563 |
GRK3 |
0.708 | -0.022 | -2 | 0.720 |
PAK5 |
0.708 | -0.026 | -2 | 0.578 |
TNIK |
0.708 | 0.040 | 3 | 0.766 |
DYRK3 |
0.708 | 0.013 | 1 | 0.715 |
CAMKK1 |
0.708 | -0.093 | -2 | 0.720 |
MAK |
0.707 | 0.058 | -2 | 0.632 |
CHK2 |
0.707 | 0.025 | -3 | 0.673 |
CDK3 |
0.707 | 0.013 | 1 | 0.547 |
MOK |
0.707 | 0.061 | 1 | 0.745 |
DAPK1 |
0.707 | -0.001 | -3 | 0.796 |
HGK |
0.706 | 0.029 | 3 | 0.766 |
MRCKA |
0.706 | 0.025 | -3 | 0.789 |
LKB1 |
0.706 | -0.028 | -3 | 0.816 |
CAMKK2 |
0.706 | -0.064 | -2 | 0.710 |
TAK1 |
0.705 | -0.001 | 1 | 0.845 |
PINK1 |
0.705 | -0.122 | 1 | 0.841 |
NEK1 |
0.705 | 0.046 | 1 | 0.852 |
DMPK1 |
0.704 | 0.066 | -3 | 0.790 |
VRK1 |
0.704 | -0.028 | 2 | 0.785 |
KHS2 |
0.704 | 0.074 | 1 | 0.804 |
LOK |
0.703 | 0.010 | -2 | 0.702 |
CK2A1 |
0.703 | 0.016 | 1 | 0.676 |
KHS1 |
0.703 | 0.061 | 1 | 0.795 |
MST1 |
0.703 | 0.023 | 1 | 0.812 |
PAK4 |
0.702 | -0.032 | -2 | 0.577 |
CK1G1 |
0.702 | -0.009 | -3 | 0.515 |
ROCK1 |
0.701 | 0.064 | -3 | 0.790 |
DYRK4 |
0.701 | -0.013 | 1 | 0.600 |
CDK6 |
0.700 | 0.006 | 1 | 0.608 |
BUB1 |
0.699 | 0.010 | -5 | 0.735 |
HASPIN |
0.698 | 0.007 | -1 | 0.527 |
JNK1 |
0.697 | -0.016 | 1 | 0.587 |
PKG1 |
0.697 | 0.007 | -2 | 0.517 |
PBK |
0.696 | 0.030 | 1 | 0.804 |
MEK2 |
0.695 | -0.071 | 2 | 0.739 |
RIPK2 |
0.695 | -0.097 | 1 | 0.775 |
SBK |
0.694 | 0.028 | -3 | 0.615 |
CDK4 |
0.694 | -0.019 | 1 | 0.582 |
PLK2 |
0.694 | -0.057 | -3 | 0.705 |
SLK |
0.694 | -0.030 | -2 | 0.677 |
PDHK3_TYR |
0.694 | 0.046 | 4 | 0.209 |
NEK3 |
0.693 | -0.025 | 1 | 0.793 |
CRIK |
0.693 | 0.035 | -3 | 0.748 |
P38D |
0.692 | -0.021 | 1 | 0.528 |
MYO3B |
0.691 | 0.042 | 2 | 0.829 |
STK33 |
0.691 | -0.093 | 2 | 0.545 |
TTK |
0.691 | -0.018 | -2 | 0.739 |
TAO1 |
0.690 | 0.020 | 1 | 0.751 |
PKMYT1_TYR |
0.690 | 0.094 | 3 | 0.798 |
OSR1 |
0.689 | -0.035 | 2 | 0.780 |
TESK1_TYR |
0.689 | 0.011 | 3 | 0.830 |
PDHK4_TYR |
0.689 | 0.057 | 2 | 0.762 |
MAP2K7_TYR |
0.688 | 0.068 | 2 | 0.762 |
MYO3A |
0.688 | 0.027 | 1 | 0.803 |
BMPR2_TYR |
0.687 | 0.011 | -1 | 0.701 |
MAP2K4_TYR |
0.687 | -0.010 | -1 | 0.679 |
PINK1_TYR |
0.686 | -0.007 | 1 | 0.885 |
ASK1 |
0.685 | 0.008 | 1 | 0.790 |
LIMK2_TYR |
0.685 | 0.016 | -3 | 0.890 |
MAP2K6_TYR |
0.684 | -0.040 | -1 | 0.667 |
LIMK1_TYR |
0.684 | 0.036 | 2 | 0.792 |
BIKE |
0.684 | 0.020 | 1 | 0.770 |
ALPHAK3 |
0.683 | -0.052 | -1 | 0.586 |
YANK3 |
0.681 | -0.046 | 2 | 0.321 |
PDHK1_TYR |
0.681 | -0.046 | -1 | 0.662 |
EPHA6 |
0.679 | -0.035 | -1 | 0.641 |
TYK2 |
0.676 | -0.042 | 1 | 0.843 |
DDR1 |
0.676 | -0.071 | 4 | 0.202 |
MST1R |
0.676 | -0.058 | 3 | 0.743 |
ROS1 |
0.674 | -0.047 | 3 | 0.726 |
TNNI3K_TYR |
0.674 | 0.061 | 1 | 0.819 |
YES1 |
0.673 | -0.036 | -1 | 0.601 |
RET |
0.673 | -0.108 | 1 | 0.851 |
ABL2 |
0.671 | -0.056 | -1 | 0.577 |
STLK3 |
0.670 | -0.080 | 1 | 0.769 |
TYRO3 |
0.670 | -0.094 | 3 | 0.744 |
JAK2 |
0.670 | -0.074 | 1 | 0.831 |
JAK3 |
0.670 | -0.063 | 1 | 0.840 |
BLK |
0.670 | 0.029 | -1 | 0.624 |
CSF1R |
0.670 | -0.062 | 3 | 0.738 |
EPHB4 |
0.670 | -0.095 | -1 | 0.595 |
LCK |
0.670 | -0.013 | -1 | 0.613 |
CK1A |
0.669 | -0.010 | -3 | 0.388 |
TNK1 |
0.669 | -0.020 | 3 | 0.725 |
FGR |
0.669 | -0.056 | 1 | 0.894 |
TXK |
0.669 | -0.019 | 1 | 0.834 |
KDR |
0.669 | -0.026 | 3 | 0.722 |
AAK1 |
0.668 | 0.041 | 1 | 0.665 |
JAK1 |
0.666 | 0.009 | 1 | 0.781 |
ABL1 |
0.666 | -0.059 | -1 | 0.571 |
HCK |
0.666 | -0.061 | -1 | 0.609 |
TNK2 |
0.666 | -0.059 | 3 | 0.707 |
NEK10_TYR |
0.665 | -0.023 | 1 | 0.729 |
MET |
0.665 | -0.046 | 3 | 0.725 |
INSRR |
0.664 | -0.090 | 3 | 0.722 |
PDGFRB |
0.664 | -0.088 | 3 | 0.757 |
FER |
0.664 | -0.120 | 1 | 0.889 |
FYN |
0.663 | -0.001 | -1 | 0.615 |
WEE1_TYR |
0.662 | -0.048 | -1 | 0.541 |
TEC |
0.662 | -0.059 | -1 | 0.525 |
FGFR2 |
0.662 | -0.105 | 3 | 0.766 |
FLT3 |
0.662 | -0.086 | 3 | 0.733 |
TEK |
0.660 | -0.082 | 3 | 0.709 |
KIT |
0.660 | -0.099 | 3 | 0.748 |
FGFR1 |
0.660 | -0.073 | 3 | 0.740 |
EPHA4 |
0.660 | -0.093 | 2 | 0.630 |
SRMS |
0.659 | -0.126 | 1 | 0.867 |
ERBB2 |
0.658 | -0.073 | 1 | 0.831 |
ITK |
0.658 | -0.101 | -1 | 0.576 |
ALK |
0.658 | -0.085 | 3 | 0.688 |
EPHB1 |
0.658 | -0.135 | 1 | 0.855 |
BMX |
0.658 | -0.072 | -1 | 0.528 |
PDGFRA |
0.658 | -0.116 | 3 | 0.749 |
FLT1 |
0.658 | -0.070 | -1 | 0.611 |
AXL |
0.657 | -0.116 | 3 | 0.741 |
DDR2 |
0.657 | -0.049 | 3 | 0.713 |
BTK |
0.657 | -0.121 | -1 | 0.533 |
EPHB3 |
0.657 | -0.127 | -1 | 0.576 |
FRK |
0.656 | -0.063 | -1 | 0.605 |
EPHB2 |
0.656 | -0.108 | -1 | 0.573 |
LTK |
0.656 | -0.098 | 3 | 0.711 |
MERTK |
0.655 | -0.115 | 3 | 0.737 |
EPHA1 |
0.654 | -0.103 | 3 | 0.703 |
SRC |
0.653 | -0.037 | -1 | 0.601 |
YANK2 |
0.653 | -0.056 | 2 | 0.334 |
FLT4 |
0.653 | -0.099 | 3 | 0.727 |
PTK6 |
0.653 | -0.148 | -1 | 0.495 |
LYN |
0.653 | -0.069 | 3 | 0.680 |
EPHA3 |
0.652 | -0.120 | 2 | 0.620 |
EPHA7 |
0.652 | -0.109 | 2 | 0.655 |
FGFR3 |
0.652 | -0.094 | 3 | 0.744 |
PTK2 |
0.652 | -0.016 | -1 | 0.640 |
NTRK2 |
0.652 | -0.120 | 3 | 0.719 |
CK1G3 |
0.650 | -0.029 | -3 | 0.344 |
NTRK1 |
0.650 | -0.158 | -1 | 0.570 |
INSR |
0.649 | -0.114 | 3 | 0.683 |
SYK |
0.647 | -0.008 | -1 | 0.600 |
MATK |
0.647 | -0.085 | -1 | 0.519 |
EGFR |
0.646 | -0.059 | 1 | 0.755 |
NTRK3 |
0.646 | -0.119 | -1 | 0.529 |
PTK2B |
0.645 | -0.088 | -1 | 0.537 |
MUSK |
0.644 | -0.053 | 1 | 0.761 |
EPHA8 |
0.644 | -0.095 | -1 | 0.594 |
EPHA5 |
0.643 | -0.127 | 2 | 0.617 |
CK1G2 |
0.641 | -0.013 | -3 | 0.434 |
ERBB4 |
0.640 | -0.031 | 1 | 0.756 |
FGFR4 |
0.638 | -0.101 | -1 | 0.543 |
IGF1R |
0.636 | -0.117 | 3 | 0.645 |
CSK |
0.634 | -0.152 | 2 | 0.650 |
EPHA2 |
0.632 | -0.123 | -1 | 0.569 |
ZAP70 |
0.628 | -0.013 | -1 | 0.561 |
FES |
0.626 | -0.111 | -1 | 0.506 |