Motif 853 (n=217)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0JNW5 | BLTP3B | S1007 | ochoa | Bridge-like lipid transfer protein family member 3B (Syntaxin-6 Habc-interacting protein of 164 kDa) (UHRF1-binding protein 1-like) | Tube-forming lipid transport protein which mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567). Required for retrograde traffic of vesicle clusters in the early endocytic pathway to the Golgi complex (PubMed:20163565, PubMed:35499567). {ECO:0000269|PubMed:20163565, ECO:0000269|PubMed:35499567}. |
| A2RUS2 | DENND3 | S502 | ochoa | DENN domain-containing protein 3 | Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form (PubMed:20937701). Regulates autophagy in response to starvation through RAB12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards RAB12 (By similarity). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the degradation of the transferrin receptor and of the amino acid transporter PAT4 (PubMed:20937701). Starvation also induces phosphorylation at Tyr-858, which leads to up-regulated GEF activity and initiates autophagy (By similarity). {ECO:0000250|UniProtKB:A2RT67, ECO:0000269|PubMed:20937701}. |
| A6NKT7 | RGPD3 | S1622 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| H3BQ06 | None | S28 | ochoa | TBC1 domain family member 24 | May act as a GTPase-activating protein for Rab family protein(s). Involved in neuronal projections development, probably through a negative modulation of ARF6 function. Involved in the regulation of synaptic vesicle trafficking. {ECO:0000256|ARBA:ARBA00046245}. |
| O14561 | NDUFAB1 | S99 | ochoa | Acyl carrier protein, mitochondrial (ACP) (CI-SDAP) (NADH-ubiquinone oxidoreductase 9.6 kDa subunit) | Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) (PubMed:27626371). Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain (PubMed:27626371). Accessory protein, of the core iron-sulfur cluster (ISC) assembly complex, that regulates, in association with LYRM4, the stability and the cysteine desulfurase activity of NFS1 and participates in the [2Fe-2S] clusters assembly on the scaffolding protein ISCU (PubMed:31664822). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity). {ECO:0000250|UniProtKB:P52505, ECO:0000250|UniProtKB:Q9H1K1, ECO:0000269|PubMed:27626371, ECO:0000269|PubMed:31664822}. |
| O14715 | RGPD8 | S1621 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O14976 | GAK | S1185 | ochoa | Cyclin-G-associated kinase (EC 2.7.11.1) (DnaJ homolog subfamily C member 26) | Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 (PubMed:10625686). May play a role in clathrin-mediated endocytosis and intracellular trafficking, and in the dynamics of clathrin assembly/disassembly (PubMed:18489706). {ECO:0000269|PubMed:10625686, ECO:0000269|PubMed:18489706}. |
| O15049 | N4BP3 | S130 | ochoa | NEDD4-binding protein 3 (N4BP3) | Plays a positive role in the antiviral innate immune signaling pathway. Mechanistically, interacts with MAVS and functions as a positive regulator to promote 'Lys-63'-linked polyubiquitination of MAVS and thus strengthens the interaction between MAVS and TRAF2 (PubMed:34880843). Also plays a role in axon and dendrite arborization during cranial nerve development. May also be important for neural crest migration and early development of other anterior structures including eye, brain and cranial cartilage (By similarity). {ECO:0000250|UniProtKB:A0A1L8GXY6, ECO:0000269|PubMed:34880843}. |
| O15055 | PER2 | S700 | psp | Period circadian protein homolog 2 (hPER2) (Circadian clock protein PERIOD 2) | Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndrome and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. PER1 and PER2 proteins transport CRY1 and CRY2 into the nucleus with appropriate circadian timing, but also contribute directly to repression of clock-controlled target genes through interaction with several classes of RNA-binding proteins, helicases and others transcriptional repressors. PER appears to regulate circadian control of transcription by at least three different modes. First, interacts directly with the CLOCK-BMAL1 at the tail end of the nascent transcript peak to recruit complexes containing the SIN3-HDAC that remodel chromatin to repress transcription. Second, brings H3K9 methyltransferases such as SUV39H1 and SUV39H2 to the E-box elements of the circadian target genes, like PER2 itself or PER1. The recruitment of each repressive modifier to the DNA seems to be very precisely temporally orchestrated by the large PER complex, the deacetylases acting before than the methyltransferases. Additionally, large PER complexes are also recruited to the target genes 3' termination site through interactions with RNA-binding proteins and helicases that may play a role in transcription termination to regulate transcription independently of CLOCK-BMAL1 interactions. Recruitment of large PER complexes to the elongating polymerase at PER and CRY termination sites inhibited SETX action, impeding RNA polymerase II release and thereby repressing transcriptional reinitiation. May propagate clock information to metabolic pathways via the interaction with nuclear receptors. Coactivator of PPARA and corepressor of NR1D1, binds rhythmically at the promoter of nuclear receptors target genes like BMAL1 or G6PC1. Directly and specifically represses PPARG proadipogenic activity by blocking PPARG recruitment to target promoters and thereby inhibiting transcriptional activation. Required for fatty acid and lipid metabolism, is involved as well in the regulation of circulating insulin levels. Plays an important role in the maintenance of cardiovascular functions through the regulation of NO and vasodilatatory prostaglandins production in aortas. Controls circadian glutamate uptake in synaptic vesicles through the regulation of VGLUT1 expression. May also be involved in the regulation of inflammatory processes. Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1 and ATF4. Negatively regulates the formation of the TIMELESS-CRY1 complex by competing with TIMELESS for binding to CRY1. {ECO:0000250|UniProtKB:O54943}. |
| O15294 | OGT | S20 | ochoa|psp | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (EC 2.4.1.255) (O-GlcNAc transferase subunit p110) (O-linked N-acetylglucosamine transferase 110 kDa subunit) (OGT) | Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc) (PubMed:12150998, PubMed:15361863, PubMed:19451179, PubMed:20018868, PubMed:21240259, PubMed:21285374, PubMed:23103939, PubMed:26237509, PubMed:26369908, PubMed:26678539, PubMed:27713473, PubMed:37541260, PubMed:37962578). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, AMPK, ATG4B, CAPRIN1, EZH2, FNIP1, GSDMD, KRT7, LMNA, LMNB1, LMNB2, RPTOR, HOXA1, PFKL, KMT2E/MLL5, MAPT/TAU, TET2, RBL2, RET, NOD2 and HCFC1 (PubMed:19451179, PubMed:20200153, PubMed:21285374, PubMed:22923583, PubMed:23353889, PubMed:24474760, PubMed:26237509, PubMed:26369908, PubMed:26678539, PubMed:27527864, PubMed:30699359, PubMed:34074792, PubMed:34667079, PubMed:37541260, PubMed:37962578). Can regulate their cellular processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing (PubMed:21285374). Involved in insulin resistance in muscle and adipocyte cells via glycosylating insulin signaling components and inhibiting the 'Thr-308' phosphorylation of AKT1, enhancing IRS1 phosphorylation and attenuating insulin signaling (By similarity). Involved in glycolysis regulation by mediating glycosylation of 6-phosphofructokinase PFKL, inhibiting its activity (PubMed:22923583). Plays a key role in chromatin structure by mediating O-GlcNAcylation of 'Ser-112' of histone H2B: recruited to CpG-rich transcription start sites of active genes via its interaction with TET proteins (TET1, TET2 or TET3) (PubMed:22121020, PubMed:23353889). As part of the NSL complex indirectly involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). O-GlcNAcylation of 'Ser-75' of EZH2 increases its stability, and facilitating the formation of H3K27me3 by the PRC2/EED-EZH2 complex (PubMed:24474760). Stabilizes KMT2E/MLL5 by mediating its glycosylation, thereby preventing KMT2E/MLL5 ubiquitination (PubMed:26678539). Regulates circadian oscillation of the clock genes and glucose homeostasis in the liver (By similarity). Stabilizes clock proteins BMAL1 and CLOCK through O-glycosylation, which prevents their ubiquitination and subsequent degradation (By similarity). Promotes the CLOCK-BMAL1-mediated transcription of genes in the negative loop of the circadian clock such as PER1/2 and CRY1/2. O-glycosylates HCFC1 and regulates its proteolytic processing and transcriptional activity (PubMed:21285374, PubMed:28302723, PubMed:28584052). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (PubMed:20200153). Regulates mitochondrial motility in neurons by mediating glycosylation of TRAK1 (By similarity). Promotes autophagy by mediating O-glycosylation of ATG4B (PubMed:27527864). Acts as a regulator of mTORC1 signaling by mediating O-glycosylation of RPTOR and FNIP1: O-GlcNAcylation of RPTOR in response to glucose sufficiency promotes activation of the mTORC1 complex (PubMed:30699359, PubMed:37541260). {ECO:0000250|UniProtKB:P56558, ECO:0000250|UniProtKB:Q8CGY8, ECO:0000269|PubMed:12150998, ECO:0000269|PubMed:15361863, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:20018868, ECO:0000269|PubMed:20200153, ECO:0000269|PubMed:21240259, ECO:0000269|PubMed:21285374, ECO:0000269|PubMed:22121020, ECO:0000269|PubMed:22923583, ECO:0000269|PubMed:23103939, ECO:0000269|PubMed:23353889, ECO:0000269|PubMed:24474760, ECO:0000269|PubMed:24563466, ECO:0000269|PubMed:26237509, ECO:0000269|PubMed:26369908, ECO:0000269|PubMed:26678539, ECO:0000269|PubMed:27527864, ECO:0000269|PubMed:28302723, ECO:0000269|PubMed:28584052, ECO:0000269|PubMed:30699359, ECO:0000269|PubMed:34074792, ECO:0000269|PubMed:34667079, ECO:0000269|PubMed:37541260, ECO:0000269|PubMed:37962578}.; FUNCTION: [Isoform 2]: The mitochondrial isoform (mOGT) is cytotoxic and triggers apoptosis in several cell types including INS1, an insulinoma cell line. {ECO:0000269|PubMed:20824293}.; FUNCTION: [Isoform 4]: Has N-acetylglucosaminyltransferase activity: glycosylates proteins, such as HNRNPU, NEUROD1, NUP62 and PDCD6IP (PubMed:31527085). Displays specific substrate selectivity compared to other isoforms (PubMed:31527085). {ECO:0000269|PubMed:31527085}. |
| O43194 | GPR39 | S427 | ochoa | G-protein coupled receptor 39 | Zinc-sensing receptor that can sense changes in extracellular Zn(2+), mediate Zn(2+) signal transmission, and participates in the regulation of numerous physiological processes including glucose homeostasis regulation, gastrointestinal mobility, hormone secretion and cell death (PubMed:18180304). Activation by Zn(2+) in keratinocytes increases the intracellular concentration of Ca(2+) and activates the ERK/MAPK and PI3K/AKT signaling pathways leading to epithelial repair (PubMed:20522546). Plays an essential role in normal wound healing by inducing the production of cytokines including the major inflammatory cytokine IL6 via the PKC/MAPK/CEBPB pathway (By similarity). Regulates adipose tissue metabolism, especially lipolysis, and regulates the function of lipases, such as hormone-sensitive lipase and adipose triglyceride lipase (By similarity). Plays a role in the inhibition of cell death and protects against oxidative, endoplasmic reticulum and mitochondrial stress by inducing secretion of the cytoprotective pigment epithelium-derived growth factor (PEDF) and probably other protective transcripts in a GNA13/RHOA/SRE-dependent manner (PubMed:18180304). Forms dynamic heteroreceptor complexes with HTR1A and GALR1 depending on cell type or specific physiological states, resulting in signaling diversity: HTR1A-GPR39 shows additive increase in signaling along the serum response element (SRE) and NF-kappa-B pathways while GALR1 acts as an antagonist blocking SRE (PubMed:26365466). {ECO:0000250|UniProtKB:Q5U431, ECO:0000269|PubMed:18180304, ECO:0000269|PubMed:20522546, ECO:0000269|PubMed:26365466}. |
| O43347 | MSI1 | S231 | ochoa | RNA-binding protein Musashi homolog 1 (Musashi-1) | RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'-GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'-[GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity). {ECO:0000250}. |
| O60333 | KIF1B | S1054 | ochoa | Kinesin-like protein KIF1B (Klp) (EC 5.6.1.3) | Has a plus-end-directed microtubule motor activity and functions as a motor for transport of vesicles and organelles along microtubules. {ECO:0000269|PubMed:16225668}.; FUNCTION: [Isoform 2]: Has a plus-end-directed microtubule motor activity and functions as a motor for anterograde synaptic vesicle transport along axonal microtubules from the cell body to the presynapse in neuronal cells (By similarity). Functions as a downstream effector in a developmental apoptotic pathway that is activated when nerve growth factor (NGF) becomes limiting for neuronal progenitor cells (PubMed:18334619). {ECO:0000250|UniProtKB:Q60575, ECO:0000269|PubMed:18334619}.; FUNCTION: [Isoform 3]: Has a plus-end-directed microtubule motor activity and functions as a motor for anterograde transport of mitochondria. {ECO:0000269|PubMed:16225668}. |
| O75112 | LDB3 | S44 | ochoa | LIM domain-binding protein 3 (Protein cypher) (Z-band alternatively spliced PDZ-motif protein) | May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton. {ECO:0000305}. |
| O75376 | NCOR1 | S2120 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O75387 | SLC43A1 | S237 | ochoa | Large neutral amino acids transporter small subunit 3 (L-type amino acid transporter 3) (Prostate cancer overexpressed gene 1 protein) (Solute carrier family 43 member 1) | Uniport that mediates the transport of neutral amino acids such as L-leucine, L-isoleucine, L-valine, and L-phenylalanine (PubMed:12930836). The transport activity is sodium ions-independent, electroneutral and mediated by a facilitated diffusion (PubMed:12930836). {ECO:0000269|PubMed:12930836}. |
| O75665 | OFD1 | S954 | ochoa | Centriole and centriolar satellite protein OFD1 (Oral-facial-digital syndrome 1 protein) (Protein 71-7A) | Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164 (By similarity). Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis (PubMed:33934390). Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation (By similarity). {ECO:0000250|UniProtKB:Q80Z25, ECO:0000269|PubMed:33934390}. |
| O75781 | PALM | S189 | ochoa | Paralemmin-1 (Paralemmin) | Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner. {ECO:0000269|PubMed:14978216}. |
| O75943 | RAD17 | S362 | psp | Cell cycle checkpoint protein RAD17 (hRad17) (RF-C/activator 1 homolog) | Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage (PubMed:10208430, PubMed:11418864, PubMed:11687627, PubMed:11799063, PubMed:12672690, PubMed:14624239, PubMed:15235112). Has a weak ATPase activity required for binding to chromatin (PubMed:10208430, PubMed:11418864, PubMed:11687627, PubMed:11799063, PubMed:12672690, PubMed:14624239, PubMed:15235112). Participates in the recruitment of the 9-1-1 (RAD1-RAD9-HUS1) complex and RHNO1 onto chromatin, and in CHEK1 activation (PubMed:21659603). Involved in homologous recombination by mediating recruitment of the MRN complex to DNA damage sites (PubMed:24534091). May also serve as a sensor of DNA replication progression (PubMed:12578958, PubMed:14500819, PubMed:15538388). {ECO:0000269|PubMed:10208430, ECO:0000269|PubMed:11418864, ECO:0000269|PubMed:11687627, ECO:0000269|PubMed:11799063, ECO:0000269|PubMed:12578958, ECO:0000269|PubMed:12672690, ECO:0000269|PubMed:14500819, ECO:0000269|PubMed:14624239, ECO:0000269|PubMed:15235112, ECO:0000269|PubMed:15538388, ECO:0000269|PubMed:21659603, ECO:0000269|PubMed:24534091}. |
| O75969 | AKAP3 | S208 | ochoa | A-kinase anchor protein 3 (AKAP-3) (A-kinase anchor protein 110 kDa) (AKAP 110) (Cancer/testis antigen 82) (CT82) (Fibrous sheath protein of 95 kDa) (FSP95) (Fibrousheathin I) (Fibrousheathin-1) (Protein kinase A-anchoring protein 3) (PRKA3) (Sperm oocyte-binding protein) | Structural component of sperm fibrous sheath (By similarity). Required for the formation of the subcellular structure of the sperm flagellum, sperm motility and male fertility (PubMed:35228300). {ECO:0000250|UniProtKB:O88987, ECO:0000269|PubMed:35228300}. |
| O94823 | ATP10B | S1417 | ochoa | Phospholipid-transporting ATPase VB (EC 7.6.2.1) (ATPase class V type 10B) (P4-ATPase flippase complex alpha subunit ATP10B) | Catalytic component of a P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of glucosylceramide (GlcCer) from the outer to the inner leaflet of lysosome membranes. Plays an important role in the maintenance of lysosome membrane integrity and function in cortical neurons. {ECO:0000269|PubMed:32172343}. |
| O94915 | FRYL | S479 | ochoa | Protein furry homolog-like (ALL1-fused gene from chromosome 4p12 protein) | Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching (By similarity). May function as a transcriptional activator. {ECO:0000250, ECO:0000269|PubMed:16061630}. |
| O94953 | KDM4B | S197 | ochoa | Lysine-specific demethylase 4B (EC 1.14.11.66) (JmjC domain-containing histone demethylation protein 3B) (Jumonji domain-containing protein 2B) ([histone H3]-trimethyl-L-lysine(9) demethylase 4B) | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate (PubMed:16603238, PubMed:28262558). Plays a critical role in the development of the central nervous system (CNS). {ECO:0000250|UniProtKB:Q91VY5, ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:28262558}. |
| O95069 | KCNK2 | S385 | ochoa | Potassium channel subfamily K member 2 (Outward rectifying potassium channel protein TREK-1) (TREK-1 K(+) channel subunit) (Two pore domain potassium channel TREK1) (Two pore potassium channel TPKC1) (K2P2.1) | K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate. Converts to voltage-independent 'leak' conductance mode upon stimulation by various stimuli including mechanical membrane stretch, acidic pH, heat and lipids. Reversibly converts between a voltage-insensitive K(+) 'leak' channel and a voltage-dependent outward rectifying K(+) channel in a phosphorylation-dependent manner (By similarity) (PubMed:10321245, PubMed:10784345, PubMed:11319556, PubMed:23169818, PubMed:30573346, PubMed:38605031). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (By similarity). In trigeminal ganglia sensory neurons, the heterodimer of KCNK2/TREK-1 and KCNK18/TRESK inhibits neuronal firing and neurogenic inflammation by stabilizing the resting membrane potential at K(+) equilibrium potential as well as by regulating the threshold of action potentials and the spike frequency (By similarity). At trigeminal A-beta afferent nerves, the heterodimer of KCNK2/TREK-1 and KCNK4/TRAAK is mostly coexpressed at nodes of Ranvier where it conducts voltage-independent mechanosensitive and thermosensitive currents, allowing rapid action potential repolarization, high speed and high frequence saltatory conduction on myelinated nerves to ensure prompt sensory responses (By similarity). In hippocampal astrocytes, the heterodimer of KCNK2/TREK-1 and KCNK1/TWIK-1 allows passive K(+) conductance under basal conditions, but changes ion selectivity and becomes permeable to L-glutamate and Cl(-) ions upon binding to G-protein subunit GNG4 in stimulated astrocytes. Mediates rapid L-glutamate release in response to activation of G-protein-coupled receptors, such as F2R and CNR1 (By similarity). In hippocampal pyramidal neurons, the homodimer of KCNK2/TREK-1 contributes to gamma-aminobutyric acid (GABA) B-induced slow inhibitory postsynaptic potential. Associates with AKAP5 and Gs-protein-coupled receptor B2AR at postsynaptic dense bodies and converts to a leak channel no longer sensitive to stimulation by arachidonic acid, acidic pH or mechanical stress, nor inhibited by Gq-coupled receptors but still under the negative control of Gs-coupled receptors (By similarity). Permeable to other monovalent cations such as Rb(+) and Cs(+) (By similarity). {ECO:0000250|UniProtKB:P97438, ECO:0000250|UniProtKB:Q920B6, ECO:0000269|PubMed:10321245, ECO:0000269|PubMed:10784345, ECO:0000269|PubMed:11319556, ECO:0000269|PubMed:23169818, ECO:0000269|PubMed:30573346, ECO:0000269|PubMed:38605031}.; FUNCTION: [Isoform 4]: Does not display channel activity but reduces the channel activity of isoform 1 and isoform 2 and reduces cell surface expression of isoform 2. {ECO:0000250|UniProtKB:Q920B6}. |
| O95613 | PCNT | S2878 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| O95747 | OXSR1 | S324 | ochoa | Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress-responsive 1 protein) | Effector serine/threonine-protein kinase component of the WNK-SPAK/OSR1 kinase cascade, which is involved in various processes, such as ion transport, response to hypertonic stress and blood pressure (PubMed:16669787, PubMed:18270262, PubMed:21321328, PubMed:34289367). Specifically recognizes and binds proteins with a RFXV motif (PubMed:16669787, PubMed:17721439, PubMed:21321328). Acts downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4): following activation by WNK kinases, catalyzes phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:17721439). Mediates regulatory volume increase in response to hyperosmotic stress by catalyzing phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1 and SLC12A6/KCC3 downstream of WNK1 and WNK3 kinases (PubMed:16669787, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:16669787, PubMed:19665974, PubMed:21321328). Acts as a regulator of NaCl reabsorption in the distal nephron by mediating phosphorylation and activation of the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney downstream of WNK4 (PubMed:18270262). Also acts as a regulator of angiogenesis in endothelial cells downstream of WNK1 (PubMed:23386621, PubMed:25362046). Acts as an activator of inward rectifier potassium channels KCNJ2/Kir2.1 and KCNJ4/Kir2.3 downstream of WNK1: recognizes and binds the RXFXV/I variant motif on KCNJ2/Kir2.1 and KCNJ4/Kir2.3 and regulates their localization to the cell membrane without mediating their phosphorylation (PubMed:29581290). Phosphorylates RELL1, RELL2 and RELT (PubMed:16389068, PubMed:28688764). Phosphorylates PAK1 (PubMed:14707132). Phosphorylates PLSCR1 in the presence of RELT (PubMed:22052202). {ECO:0000269|PubMed:14707132, ECO:0000269|PubMed:16389068, ECO:0000269|PubMed:16669787, ECO:0000269|PubMed:17721439, ECO:0000269|PubMed:18270262, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22052202, ECO:0000269|PubMed:23386621, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:28688764, ECO:0000269|PubMed:29581290, ECO:0000269|PubMed:34289367}. |
| O95865 | DDAH2 | S253 | psp | Putative hydrolase DDAH2 (EC 3.-.-.-) (DDAHII) (Inactive N(G),N(G)-dimethylarginine dimethylaminohydrolase 2) (DDAH-2) (Inactive dimethylarginine dimethylaminohydrolase 2) (Protein G6a) (S-phase protein) | Putative hydrolase with unknown substrate (Probable). Does not hydrolyze N(G),N(G)-dimethyl-L-arginine (ADMA) which acts as an inhibitor of NOS (PubMed:21493890, PubMed:37296100). In endothelial cells, induces expression of vascular endothelial growth factor (VEGF) via phosphorylation of the transcription factor SP1 by PKA in a process that is independent of NO and NO synthase (By similarity). Similarly, enhances pancreatic insulin secretion through SP1-mediated transcriptional up-regulation of secretagogin/SCGN, an insulin vesicle docking protein (By similarity). Upon viral infection, relocates to mitochondria where it promotes mitochondrial fission through activation of DNM1L leading to the inhibition of innate response activation mediated by MAVS (PubMed:33850055). {ECO:0000250|UniProtKB:Q99LD8, ECO:0000269|PubMed:21493890, ECO:0000269|PubMed:33850055, ECO:0000269|PubMed:37296100, ECO:0000305|PubMed:10493931, ECO:0000305|PubMed:21493890, ECO:0000305|PubMed:37296100}. |
| O95905 | ECD | S419 | ochoa | Protein ecdysoneless homolog (Human suppressor of GCR two) (hSGT1) | Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP (PubMed:16849563, PubMed:23880345). May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes (PubMed:19919181, PubMed:9928932). Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins (PubMed:19640839). The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex (PubMed:26711270). May play a role in regulation of pre-mRNA splicing (PubMed:24722212). Participates together with DDX39A in mRNA nuclear export (PubMed:33941617). {ECO:0000269|PubMed:16849563, ECO:0000269|PubMed:19640839, ECO:0000269|PubMed:19919181, ECO:0000269|PubMed:23880345, ECO:0000269|PubMed:26711270, ECO:0000269|PubMed:33941617, ECO:0000305|PubMed:24722212, ECO:0000305|PubMed:9928932}. |
| P00568 | AK1 | S38 | ochoa | Adenylate kinase isoenzyme 1 (AK 1) (EC 2.7.4.3) (EC 2.7.4.4) (EC 2.7.4.6) (ATP-AMP transphosphorylase 1) (ATP:AMP phosphotransferase) (Adenylate monophosphate kinase) (Myokinase) | Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) (PubMed:21080915, PubMed:23416111, PubMed:2542324). Also catalyzes at a very low rate the synthesis of thiamine triphosphate (ThTP) from thiamine diphosphate (ThDP) and ADP (By similarity). {ECO:0000250|UniProtKB:P05081, ECO:0000255|HAMAP-Rule:MF_03171, ECO:0000269|PubMed:21080915, ECO:0000269|PubMed:23416111, ECO:0000269|PubMed:2542324}. |
| P00918 | CA2 | S219 | ochoa | Carbonic anhydrase 2 (EC 4.2.1.1) (Carbonate dehydratase II) (Carbonic anhydrase C) (CAC) (Carbonic anhydrase II) (CA-II) (Cyanamide hydratase CA2) (EC 4.2.1.69) | Catalyzes the reversible hydration of carbon dioxide (PubMed:11327835, PubMed:11802772, PubMed:11831900, PubMed:12056894, PubMed:12171926, PubMed:1336460, PubMed:14736236, PubMed:15300855, PubMed:15453828, PubMed:15667203, PubMed:15865431, PubMed:16106378, PubMed:16214338, PubMed:16290146, PubMed:16686544, PubMed:16759856, PubMed:16807956, PubMed:17127057, PubMed:17251017, PubMed:17314045, PubMed:17330962, PubMed:17346964, PubMed:17540563, PubMed:17588751, PubMed:17705204, PubMed:18024029, PubMed:18162396, PubMed:18266323, PubMed:18374572, PubMed:18481843, PubMed:18618712, PubMed:18640037, PubMed:18942852, PubMed:1909891, PubMed:1910042, PubMed:19170619, PubMed:19186056, PubMed:19206230, PubMed:19520834, PubMed:19778001, PubMed:7761440, PubMed:7901850, PubMed:8218160, PubMed:8262987, PubMed:8399159, PubMed:8451242, PubMed:8485129, PubMed:8639494, PubMed:9265618, PubMed:9398308). Can also hydrate cyanamide to urea (PubMed:10550681, PubMed:11015219). Stimulates the chloride-bicarbonate exchange activity of SLC26A6 (PubMed:15990874). Essential for bone resorption and osteoclast differentiation (PubMed:15300855). Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. {ECO:0000269|PubMed:10550681, ECO:0000269|PubMed:11015219, ECO:0000269|PubMed:11327835, ECO:0000269|PubMed:11802772, ECO:0000269|PubMed:11831900, ECO:0000269|PubMed:12056894, ECO:0000269|PubMed:12171926, ECO:0000269|PubMed:1336460, ECO:0000269|PubMed:14736236, ECO:0000269|PubMed:15300855, ECO:0000269|PubMed:15453828, ECO:0000269|PubMed:15667203, ECO:0000269|PubMed:15865431, ECO:0000269|PubMed:15990874, ECO:0000269|PubMed:16106378, ECO:0000269|PubMed:16214338, ECO:0000269|PubMed:16290146, ECO:0000269|PubMed:16686544, ECO:0000269|PubMed:16759856, ECO:0000269|PubMed:16807956, ECO:0000269|PubMed:17127057, ECO:0000269|PubMed:17251017, ECO:0000269|PubMed:17314045, ECO:0000269|PubMed:17330962, ECO:0000269|PubMed:17346964, ECO:0000269|PubMed:17540563, ECO:0000269|PubMed:17588751, ECO:0000269|PubMed:17705204, ECO:0000269|PubMed:18024029, ECO:0000269|PubMed:18162396, ECO:0000269|PubMed:18266323, ECO:0000269|PubMed:18374572, ECO:0000269|PubMed:18481843, ECO:0000269|PubMed:18618712, ECO:0000269|PubMed:18640037, ECO:0000269|PubMed:18942852, ECO:0000269|PubMed:1909891, ECO:0000269|PubMed:1910042, ECO:0000269|PubMed:19170619, ECO:0000269|PubMed:19186056, ECO:0000269|PubMed:19206230, ECO:0000269|PubMed:19520834, ECO:0000269|PubMed:19778001, ECO:0000269|PubMed:7761440, ECO:0000269|PubMed:7901850, ECO:0000269|PubMed:8218160, ECO:0000269|PubMed:8262987, ECO:0000269|PubMed:8399159, ECO:0000269|PubMed:8451242, ECO:0000269|PubMed:8485129, ECO:0000269|PubMed:8639494, ECO:0000269|PubMed:9265618, ECO:0000269|PubMed:9398308}. |
| P02748 | C9 | S260 | ochoa | Complement component C9 [Cleaved into: Complement component C9a; Complement component C9b] | Pore-forming component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis (PubMed:22832194, PubMed:26841837, PubMed:26841934, PubMed:27052168, PubMed:30552328, PubMed:6177822, PubMed:9212048, PubMed:9634479). The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways (PubMed:9212048, PubMed:9634479). The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:9212048, PubMed:9634479). Constitutes the pore-forming subunit of the MAC complex: during MAC assembly, C9 associates with the C5b8 intermediate complex, and polymerizes to complete the pore (PubMed:26841934, PubMed:30111885, PubMed:30552328, PubMed:34752492, PubMed:4055801, PubMed:6177822). {ECO:0000269|PubMed:22832194, ECO:0000269|PubMed:26841837, ECO:0000269|PubMed:26841934, ECO:0000269|PubMed:27052168, ECO:0000269|PubMed:30111885, ECO:0000269|PubMed:30552328, ECO:0000269|PubMed:34752492, ECO:0000269|PubMed:4055801, ECO:0000269|PubMed:6177822, ECO:0000269|PubMed:9212048, ECO:0000269|PubMed:9634479}. |
| P07814 | EPRS1 | S817 | ochoa | Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)] | Multifunctional protein which primarily functions within the aminoacyl-tRNA synthetase multienzyme complex, also known as multisynthetase complex. Within the complex it catalyzes the attachment of both L-glutamate and L-proline to their cognate tRNAs in a two-step reaction where the amino acid is first activated by ATP to form a covalent intermediate with AMP. Subsequently, the activated amino acid is transferred to the acceptor end of the cognate tRNA to form L-glutamyl-tRNA(Glu) and L-prolyl-tRNA(Pro) (PubMed:23263184, PubMed:24100331, PubMed:29576217, PubMed:3290852, PubMed:37212275). Upon interferon-gamma stimulation, EPRS1 undergoes phosphorylation, causing its dissociation from the aminoacyl-tRNA synthetase multienzyme complex. It is recruited to form the GAIT complex, which binds to stem loop-containing GAIT elements found in the 3'-UTR of various inflammatory mRNAs, such as ceruloplasmin. The GAIT complex inhibits the translation of these mRNAs, allowing interferon-gamma to redirect the function of EPRS1 from protein synthesis to translation inhibition in specific cell contexts (PubMed:15479637, PubMed:23071094). Furthermore, it can function as a downstream effector in the mTORC1 signaling pathway, by promoting the translocation of SLC27A1 from the cytoplasm to the plasma membrane where it mediates the uptake of long-chain fatty acid by adipocytes. Thereby, EPRS1 also plays a role in fat metabolism and more indirectly influences lifespan (PubMed:28178239). {ECO:0000269|PubMed:15479637, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:28178239, ECO:0000269|PubMed:29576217, ECO:0000269|PubMed:3290852, ECO:0000269|PubMed:37212275}. |
| P0DMU7 | CT45A6 | S103 | ochoa | Cancer/testis antigen family 45 member A6 (Cancer/testis antigen 45-6) (Cancer/testis antigen 45A6) | None |
| P0DMU8 | CT45A5 | S103 | ochoa | Cancer/testis antigen family 45 member A5 (Cancer/testis antigen 45-5) (Cancer/testis antigen 45A5) | None |
| P0DMV0 | CT45A7 | S103 | ochoa | Cancer/testis antigen family 45 member A7 (Cancer/testis antigen 45A7) | None |
| P0DMV1 | CT45A8 | S103 | ochoa | Cancer/testis antigen family 45 member A8 (Cancer/testis antigen 45A8) | None |
| P0DMV2 | CT45A9 | S103 | ochoa | Cancer/testis antigen family 45 member A9 (Cancer/testis antigen 45A9) | None |
| P10636 | MAPT | S318 | ochoa | Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}. |
| P11277 | SPTB | S35 | ochoa | Spectrin beta chain, erythrocytic (Beta-I spectrin) | Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. |
| P15056 | BRAF | S614 | psp | Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) | Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). Phosphorylates PFKFB2 (PubMed:36402789). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179). {ECO:0000269|PubMed:1508179, ECO:0000269|PubMed:21441910, ECO:0000269|PubMed:29433126, ECO:0000269|PubMed:36402789, ECO:0000305}. |
| P17600 | SYN1 | S390 | ochoa | Synapsin-1 (Brain protein 4.1) (Synapsin I) | Neuronal phosphoprotein that coats synaptic vesicles, and binds to the cytoskeleton. Acts as a regulator of synaptic vesicles trafficking, involved in the control of neurotransmitter release at the pre-synaptic terminal (PubMed:21441247, PubMed:23406870). Also involved in the regulation of axon outgrowth and synaptogenesis (By similarity). The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level (By similarity). {ECO:0000250|UniProtKB:O88935, ECO:0000250|UniProtKB:P09951, ECO:0000269|PubMed:21441247, ECO:0000269|PubMed:23406870}. |
| P17706 | PTPN2 | S293 | ochoa | Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (T-cell protein-tyrosine phosphatase) (TCPTP) | Non-receptor type tyrosine-specific phosphatase that dephosphorylates receptor protein tyrosine kinases including INSR, EGFR, CSF1R, PDGFR. Also dephosphorylates non-receptor protein tyrosine kinases like JAK1, JAK2, JAK3, Src family kinases, STAT1, STAT3 and STAT6 either in the nucleus or the cytoplasm. Negatively regulates numerous signaling pathways and biological processes like hematopoiesis, inflammatory response, cell proliferation and differentiation, and glucose homeostasis. Plays a multifaceted and important role in the development of the immune system. Functions in T-cell receptor signaling through dephosphorylation of FYN and LCK to control T-cells differentiation and activation. Dephosphorylates CSF1R, negatively regulating its downstream signaling and macrophage differentiation. Negatively regulates cytokine (IL2/interleukin-2 and interferon)-mediated signaling through dephosphorylation of the cytoplasmic kinases JAK1, JAK3 and their substrate STAT1, that propagate signaling downstream of the cytokine receptors. Also regulates the IL6/interleukin-6 and IL4/interleukin-4 cytokine signaling through dephosphorylation of STAT3 and STAT6 respectively. In addition to the immune system, it is involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. Activated by the integrin ITGA1/ITGB1, it dephosphorylates EGFR and negatively regulates EGF signaling. Dephosphorylates PDGFRB and negatively regulates platelet-derived growth factor receptor-beta signaling pathway and therefore cell proliferation. Negatively regulates tumor necrosis factor-mediated signaling downstream via MAPK through SRC dephosphorylation. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of the hepatocyte growth factor receptor MET. Also plays an important role in glucose homeostasis. For instance, negatively regulates the insulin receptor signaling pathway through the dephosphorylation of INSR and control gluconeogenesis and liver glucose production through negative regulation of the IL6 signaling pathways. May also bind DNA. {ECO:0000269|PubMed:10734133, ECO:0000269|PubMed:11909529, ECO:0000269|PubMed:12138178, ECO:0000269|PubMed:12612081, ECO:0000269|PubMed:14966296, ECO:0000269|PubMed:15592458, ECO:0000269|PubMed:18819921, ECO:0000269|PubMed:22080863, ECO:0000269|PubMed:9488479}. |
| P18583 | SON | S163 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
| P18848 | ATF4 | S58 | ochoa | Cyclic AMP-dependent transcription factor ATF-4 (cAMP-dependent transcription factor ATF-4) (Activating transcription factor 4) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (Tax-responsive enhancer element-binding protein 67) (TaxREB67) | Transcription factor that binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') and displays two biological functions, as regulator of metabolic and redox processes under normal cellular conditions, and as master transcription factor during integrated stress response (ISR) (PubMed:16682973, PubMed:17684156, PubMed:31023583, PubMed:31444471, PubMed:32132707). Binds to asymmetric CRE's as a heterodimer and to palindromic CRE's as a homodimer (By similarity). Core effector of the ISR, which is required for adaptation to various stress such as endoplasmic reticulum (ER) stress, amino acid starvation, mitochondrial stress or oxidative stress (PubMed:31023583, PubMed:32132707). During ISR, ATF4 translation is induced via an alternative ribosome translation re-initiation mechanism in response to EIF2S1/eIF-2-alpha phosphorylation, and stress-induced ATF4 acts as a master transcription factor of stress-responsive genes in order to promote cell recovery (PubMed:31023583, PubMed:32132706, PubMed:32132707). Promotes the transcription of genes linked to amino acid sufficiency and resistance to oxidative stress to protect cells against metabolic consequences of ER oxidation (By similarity). Activates the transcription of NLRP1, possibly in concert with other factors in response to ER stress (PubMed:26086088). Activates the transcription of asparagine synthetase (ASNS) in response to amino acid deprivation or ER stress (PubMed:11960987). However, when associated with DDIT3/CHOP, the transcriptional activation of the ASNS gene is inhibited in response to amino acid deprivation (PubMed:18940792). Together with DDIT3/CHOP, mediates programmed cell death by promoting the expression of genes involved in cellular amino acid metabolic processes, mRNA translation and the terminal unfolded protein response (terminal UPR), a cellular response that elicits programmed cell death when ER stress is prolonged and unresolved (By similarity). Activates the expression of COX7A2L/SCAF1 downstream of the EIF2AK3/PERK-mediated unfolded protein response, thereby promoting formation of respiratory chain supercomplexes and increasing mitochondrial oxidative phosphorylation (PubMed:31023583). Together with DDIT3/CHOP, activates the transcription of the IRS-regulator TRIB3 and promotes ER stress-induced neuronal cell death by regulating the expression of BBC3/PUMA in response to ER stress (PubMed:15775988). May cooperate with the UPR transcriptional regulator QRICH1 to regulate ER protein homeostasis which is critical for cell viability in response to ER stress (PubMed:33384352). In the absence of stress, ATF4 translation is at low levels and it is required for normal metabolic processes such as embryonic lens formation, fetal liver hematopoiesis, bone development and synaptic plasticity (By similarity). Acts as a regulator of osteoblast differentiation in response to phosphorylation by RPS6KA3/RSK2: phosphorylation in osteoblasts enhances transactivation activity and promotes expression of osteoblast-specific genes and post-transcriptionally regulates the synthesis of Type I collagen, the main constituent of the bone matrix (PubMed:15109498). Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). Activates transcription of SIRT4 (By similarity). Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4 (By similarity). Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes (By similarity). Mainly acts as a transcriptional activator in cellular stress adaptation, but it can also act as a transcriptional repressor: acts as a regulator of synaptic plasticity by repressing transcription, thereby inhibiting induction and maintenance of long-term memory (By similarity). Regulates synaptic functions via interaction with DISC1 in neurons, which inhibits ATF4 transcription factor activity by disrupting ATF4 dimerization and DNA-binding (PubMed:31444471). {ECO:0000250|UniProtKB:Q06507, ECO:0000269|PubMed:11960987, ECO:0000269|PubMed:15109498, ECO:0000269|PubMed:15775988, ECO:0000269|PubMed:16682973, ECO:0000269|PubMed:17684156, ECO:0000269|PubMed:18940792, ECO:0000269|PubMed:26086088, ECO:0000269|PubMed:31023583, ECO:0000269|PubMed:31444471, ECO:0000269|PubMed:32132706, ECO:0000269|PubMed:32132707, ECO:0000269|PubMed:33384352}.; FUNCTION: (Microbial infection) Binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. {ECO:0000269|PubMed:1847461}. |
| P20810 | CAST | S499 | ochoa | Calpastatin (Calpain inhibitor) (Sperm BS-17 component) | Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. |
| P21333 | FLNA | S1976 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P22059 | OSBP | S386 | ochoa | Oxysterol-binding protein 1 | Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (PubMed:24209621). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol (PubMed:15746430, PubMed:17428193). Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly (PubMed:15746430). Regulates cholesterol efflux by decreasing ABCA1 stability (PubMed:18450749). {ECO:0000269|PubMed:15746430, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:18450749, ECO:0000269|PubMed:24209621}. |
| P22460 | KCNA5 | S592 | psp | Potassium voltage-gated channel subfamily A member 5 (HPCN1) (Voltage-gated potassium channel HK2) (Voltage-gated potassium channel subunit Kv1.5) | Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:12130714). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (PubMed:12130714). Homotetrameric channels display rapid activation and slow inactivation (PubMed:12130714, PubMed:8505626). Required for normal electrical conduction including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with XIRP2 (By similarity). May play a role in regulating the secretion of insulin in normal pancreatic islets. {ECO:0000250|UniProtKB:Q61762, ECO:0000269|PubMed:12130714, ECO:0000269|PubMed:17267549, ECO:0000269|PubMed:20018952, ECO:0000269|PubMed:36917789, ECO:0000269|PubMed:8505626}.; FUNCTION: [Isoform 2]: Exhibits a faster depolarization rate, reduced voltage-dependent recovery from inactivation and an excessive cumulative inactivation. {ECO:0000269|PubMed:11524461}. |
| P24588 | AKAP5 | S178 | ochoa | A-kinase anchor protein 5 (AKAP-5) (A-kinase anchor protein 79 kDa) (AKAP 79) (H21) (cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein) | Multivalent scaffold protein that anchors the cAMP-dependent protein kinase/PKA to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors (PubMed:1512224). Association with the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade. Plays a role in long term synaptic potentiation by regulating protein trafficking from the dendritic recycling endosomes to the plasma membrane and controlling both structural and functional plasticity at excitatory synapses (PubMed:25589740). In hippocampal pyramidal neurons, recruits KCNK2/TREK-1 channel at postsynaptic dense bodies microdomains and converts it to a leak channel no longer sensitive to stimulation by arachidonic acid, acidic pH or mechanical stress, nor inhibited by Gq-coupled receptors but still under the negative control of Gs-coupled receptors (By similarity). Associates with ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where it recruits NFATC2/NFAT1 and couples store-operated Ca(2+) influx to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses (PubMed:33941685). {ECO:0000250|UniProtKB:D3YVF0, ECO:0000269|PubMed:1512224, ECO:0000269|PubMed:25589740, ECO:0000269|PubMed:33941685}. |
| P24928 | POLR2A | S27 | ochoa | DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48) | Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250|UniProtKB:G3MZY8, ECO:0000250|UniProtKB:P08775, ECO:0000269|PubMed:23748380, ECO:0000269|PubMed:24207025, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:28108474, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:8381534, ECO:0000269|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269|PubMed:18032511}. |
| P25054 | APC | S874 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P25054 | APC | S2088 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P25445 | FAS | S225 | ochoa | Tumor necrosis factor receptor superfamily member 6 (Apo-1 antigen) (Apoptosis-mediating surface antigen FAS) (FASLG receptor) (CD antigen CD95) | Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase CASP8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs CASP8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). {ECO:0000269|PubMed:19118384, ECO:0000269|PubMed:7533181, ECO:0000269|PubMed:9184224}. |
| P27105 | STOM | S244 | ochoa | Stomatin (Erythrocyte band 7 integral membrane protein) (Erythrocyte membrane protein band 7.2) (Protein 7.2b) | Regulates ion channel activity and transmembrane ion transport. Regulates ASIC2 and ASIC3 channel activity. |
| P30305 | CDC25B | S249 | ochoa|psp | M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B) | Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression (PubMed:1836978, PubMed:20360007). Directly dephosphorylates CDK1 and stimulates its kinase activity (PubMed:20360007). Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner (PubMed:17332740). The three isoforms seem to have a different level of activity (PubMed:1836978). {ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:1836978, ECO:0000269|PubMed:20360007}. |
| P36873 | PPP1CC | S48 | ochoa | Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC 3.1.3.16) (Protein phosphatase 1C catalytic subunit) | Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets (PubMed:17936702, PubMed:25012651). Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1 (PubMed:17936702). Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (PubMed:20516061). In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation (PubMed:21712997). May dephosphorylate CSNK1D and CSNK1E (By similarity). Regulates the recruitment of the SKA complex to kinetochores (PubMed:28982702). Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Together with PPP1CA (PP1-alpha subunit), dephosphorylates IFIH1/MDA5 and RIG-I leading to their activation and a functional innate immune response (PubMed:23499489). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (PubMed:35768504, PubMed:35831509). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (PubMed:35768504, PubMed:35831509). Dephosphorylates MKI67 at the onset of anaphase (PubMed:25012651). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (PubMed:35768504, PubMed:35831509). {ECO:0000250|UniProtKB:P63087, ECO:0000269|PubMed:17936702, ECO:0000269|PubMed:20516061, ECO:0000269|PubMed:21712997, ECO:0000269|PubMed:23396208, ECO:0000269|PubMed:23499489, ECO:0000269|PubMed:25012651, ECO:0000269|PubMed:28982702, ECO:0000269|PubMed:35768504, ECO:0000269|PubMed:35831509}. |
| P37802 | TAGLN2 | S163 | ochoa|psp | Transgelin-2 (Epididymis tissue protein Li 7e) (SM22-alpha homolog) | None |
| P38398 | BRCA1 | S308 | psp | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P42768 | WAS | S277 | ochoa | Actin nucleation-promoting factor WAS (Wiskott-Aldrich syndrome protein) (WASp) | Effector protein for Rho-type GTPases that regulates actin filament reorganization via its interaction with the Arp2/3 complex (PubMed:12235133, PubMed:12769847, PubMed:16275905). Important for efficient actin polymerization (PubMed:12235133, PubMed:16275905, PubMed:8625410). Possible regulator of lymphocyte and platelet function (PubMed:9405671). Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria (PubMed:18650809). In addition to its role in the cytoplasmic cytoskeleton, also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:20574068). Promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). {ECO:0000269|PubMed:12235133, ECO:0000269|PubMed:12769847, ECO:0000269|PubMed:16275905, ECO:0000269|PubMed:18650809, ECO:0000269|PubMed:20574068, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:8625410, ECO:0000269|PubMed:9405671}. |
| P43243 | MATR3 | S118 | ochoa | Matrin-3 | May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32245947}. |
| P48735 | IDH2 | S423 | ochoa | Isocitrate dehydrogenase [NADP], mitochondrial (IDH) (EC 1.1.1.42) (ICD-M) (IDP) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase) | Plays a role in intermediary metabolism and energy production (PubMed:19228619, PubMed:22416140). It may tightly associate or interact with the pyruvate dehydrogenase complex (PubMed:19228619, PubMed:22416140). {ECO:0000269|PubMed:19228619, ECO:0000269|PubMed:22416140}. |
| P49368 | CCT3 | S458 | ochoa | T-complex protein 1 subunit gamma (TCP-1-gamma) (EC 3.6.1.-) (CCT-gamma) (Chaperonin containing T-complex polypeptide 1 subunit 3) (hTRiC5) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P49792 | RANBP2 | S1374 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P50443 | SLC26A2 | S25 | ochoa | Sulfate transporter (Diastrophic dysplasia protein) (Solute carrier family 26 member 2) | Sulfate transporter which mediates sulfate uptake into chondrocytes in order to maintain adequate sulfation of proteoglycans which is needed for cartilage development (PubMed:11448940, PubMed:15294877, PubMed:20219950, PubMed:7923357). Mediates electroneutral anion exchange of sulfate ions for oxalate ions and of sulfate and oxalate ions for chloride ions (PubMed:20219950). Mediates exchange of sulfate and oxalate ions for hydroxyl ions and of chloride ions for bromide, iodide and nitrate ions (By similarity). The coupling of sulfate transport to both hydroxyl and chloride ions likely serves to ensure transport at both acidic pH when most sulfate uptake is mediated by sulfate-hydroxide exchange and alkaline pH when most sulfate uptake is mediated by sulfate-chloride exchange (By similarity). Essential for chondrocyte proliferation, differentiation and cell size expansion (By similarity). {ECO:0000250|UniProtKB:Q62273, ECO:0000269|PubMed:11448940, ECO:0000269|PubMed:15294877, ECO:0000269|PubMed:20219950, ECO:0000269|PubMed:7923357}. |
| P51587 | BRCA2 | S1099 | ochoa | Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein) | Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination (PubMed:24896180). {ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15199141, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:20729832, ECO:0000269|PubMed:20729858, ECO:0000269|PubMed:20729859, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21719596, ECO:0000269|PubMed:24485656, ECO:0000269|PubMed:24896180}. |
| P52597 | HNRNPF | S32 | ochoa | Heterogeneous nuclear ribonucleoprotein F (hnRNP F) (Nucleolin-like protein mcs94-1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein F, N-terminally processed] | Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state. {ECO:0000269|PubMed:20526337}. |
| P52746 | ZNF142 | S904 | ochoa | Zinc finger protein 142 | May be involved in transcriptional regulation. {ECO:0000305}. |
| P53794 | SLC5A3 | S594 | ochoa | Sodium/myo-inositol cotransporter (Na(+)/myo-inositol cotransporter) (Sodium/myo-inositol transporter 1) (SMIT1) (Solute carrier family 5 member 3) | Electrogenic Na(+)-coupled sugar symporter that actively transports myo-inositol and its stereoisomer scyllo-inositol across the plasma membrane, with a Na(+) to sugar coupling ratio of 2:1 (By similarity). Maintains myo-inositol concentration gradient that defines cell volume and fluid balance during osmotic stress, in particular in the fetoplacental unit and central nervous system (By similarity). Forms coregulatory complexes with voltage-gated K(+) ion channels, allosterically altering ion selectivity, voltage dependence and gating kinetics of the channel. In turn, K(+) efflux through the channel forms a local electrical gradient that modulates electrogenic Na(+)-coupled myo-inositol influx through the transporter (PubMed:24595108, PubMed:28793216). Associates with KCNQ1-KCNE2 channel in the apical membrane of choroid plexus epithelium and regulates the myo-inositol gradient between blood and cerebrospinal fluid with an impact on neuron excitability (By similarity) (PubMed:24595108). Associates with KCNQ2-KCNQ3 channel altering ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+) permeation (PubMed:28793216). Provides myo-inositol precursor for biosynthesis of phosphoinositides such as PI(4,5)P2, thus indirectly affecting the activity of phosphoinositide-dependent ion channels and Ca(2+) signaling upon osmotic stress (PubMed:27217553). {ECO:0000250|UniProtKB:P31637, ECO:0000250|UniProtKB:Q9JKZ2, ECO:0000269|PubMed:24595108, ECO:0000269|PubMed:27217553, ECO:0000269|PubMed:28793216}. |
| P54132 | BLM | S338 | ochoa|psp | RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) | ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}. |
| P54252 | ATXN3 | S272 | ochoa | Ataxin-3 (EC 3.4.19.12) (Machado-Joseph disease protein 1) (Spinocerebellar ataxia type 3 protein) | Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates (PubMed:12297501, PubMed:16118278, PubMed:17696782, PubMed:23625928, PubMed:28445460, PubMed:33157014). Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (PubMed:17696782). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By similarity). Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription (PubMed:12297501). Acts as a negative regulator of mTORC1 signaling in response to amino acid deprivation by mediating deubiquitination of RHEB, thereby promoting RHEB inactivation by the TSC-TBC complex (PubMed:33157014). Regulates autophagy via the deubiquitination of 'Lys-402' of BECN1 leading to the stabilization of BECN1 (PubMed:28445460). {ECO:0000250|UniProtKB:Q9CVD2, ECO:0000269|PubMed:12297501, ECO:0000269|PubMed:16118278, ECO:0000269|PubMed:17696782, ECO:0000269|PubMed:23625928, ECO:0000269|PubMed:28445460, ECO:0000269|PubMed:33157014}. |
| P54296 | MYOM2 | S341 | ochoa | Myomesin-2 (165 kDa connectin-associated protein) (165 kDa titin-associated protein) (M-protein) (Myomesin family member 2) | Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. |
| P55316 | FOXG1 | S19 | psp | Forkhead box protein G1 (Brain factor 1) (BF-1) (BF1) (Brain factor 2) (BF-2) (BF2) (hBF-2) (Forkhead box protein G1A) (Forkhead box protein G1B) (Forkhead box protein G1C) (Forkhead-related protein FKHL1) (HFK1) (Forkhead-related protein FKHL2) (HFK2) (Forkhead-related protein FKHL3) (HFK3) | Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon. {ECO:0000269|PubMed:12657635}. |
| P62136 | PPP1CA | S48 | ochoa | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16) | Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets (PubMed:28216226, PubMed:30158517, PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670, PubMed:39603239, PubMed:39603240). Protein phosphatase 1 (PP1) is essential for cell division, transcription elongation, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670, PubMed:39603239, PubMed:39603240). Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Catalytic component of the PNUTS-PP1 protein phosphatase complex, a protein phosphatase 1 (PP1) complex that promotes RNA polymerase II transcription pause-release, allowing transcription elongation: the PNUTS-PP1 complex mediates the release of RNA polymerase II from promoter-proximal region of genes by catalyzing dephosphorylation of proteins involved in transcription, such as AFF4, CDK9, MEPCE, INTS12, NCBP1, POLR2M/GDOWN1 and SUPT6H (PubMed:39603239, PubMed:39603240). The PNUTS-PP1 complex also regulates transcription termination by mediating dephosphorylation of SUPT5H in termination zones downstream of poly(A) sites, thereby promoting deceleration of RNA polymerase II transcription (PubMed:31677974). PNUTS-PP1 complex is also involved in the response to replication stress by mediating dephosphorylation of POLR2A at 'Ser-5' of the CTD, promoting RNA polymerase II degradation (PubMed:33264625). PNUTS-PP1 also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (PubMed:20516061). Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage (PubMed:17283141). Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development (By similarity). In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation (PubMed:21712997). May dephosphorylate CSNK1D and CSNK1E (PubMed:21712997). Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Dephosphorylates CENPA (PubMed:25556658). Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy (PubMed:26083323). Together with PPP1CC (PP1-gamma subunit), dephosphorylates IFIH1/MDA5 and RIG-I leading to their activation and a functional innate immune response (PubMed:23499489). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (PubMed:35768504, PubMed:36175670). {ECO:0000250|UniProtKB:P62137, ECO:0000269|PubMed:17283141, ECO:0000269|PubMed:20516061, ECO:0000269|PubMed:21712997, ECO:0000269|PubMed:23396208, ECO:0000269|PubMed:23499489, ECO:0000269|PubMed:25556658, ECO:0000269|PubMed:26083323, ECO:0000269|PubMed:28216226, ECO:0000269|PubMed:30158517, ECO:0000269|PubMed:31677974, ECO:0000269|PubMed:33264625, ECO:0000269|PubMed:35768504, ECO:0000269|PubMed:35830882, ECO:0000269|PubMed:35831509, ECO:0000269|PubMed:36175670, ECO:0000269|PubMed:39603239, ECO:0000269|PubMed:39603240}.; FUNCTION: (Microbial infection) Necessary for alphaviruses replication. {ECO:0000269|PubMed:29769351}. |
| P62140 | PPP1CB | S47 | ochoa | Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (PPP1CD) (EC 3.1.3.16) (EC 3.1.3.53) | Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (PubMed:35768504, PubMed:35831509, PubMed:36175670). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (PubMed:35768504, PubMed:35831509, PubMed:36175670). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (PubMed:35768504, PubMed:36175670). {ECO:0000269|PubMed:20516061, ECO:0000269|PubMed:21712997, ECO:0000269|PubMed:23396208, ECO:0000269|PubMed:35768504, ECO:0000269|PubMed:35831509, ECO:0000269|PubMed:36175670}. |
| Q01082 | SPTBN1 | S778 | ochoa | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
| Q01082 | SPTBN1 | S1388 | ochoa | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
| Q01118 | SCN7A | S791 | ochoa | Sodium channel protein type 7 subunit alpha (Atypical sodium channel Nav2.1) (Nax channel) (Sodium channel protein type VII subunit alpha) | Sodium leak channel functioning as an osmosensor regulating sodium ion levels in various tissues and organs. While most sodium channels are voltage-gated, SCN7A is not and lets sodium flow through membrane along its concentration gradient (PubMed:26537257, PubMed:35301303). In glial cells of the central nervous system, senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake through activation of nearby neurons to maintain appropriate sodium levels in the body (By similarity). By mediating sodium influx into keratinocytes, also plays a role in skin barrier homeostasis (PubMed:26537257). {ECO:0000250|UniProtKB:B1AYL1, ECO:0000269|PubMed:26537257, ECO:0000269|PubMed:35301303}. |
| Q01201 | RELB | S41 | ochoa | Transcription factor RelB (I-Rel) | NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer in a CRY1/CRY2 independent manner. Increased repression of the heterodimer is seen in the presence of NFKB2/p52. Is required for both T and B lymphocyte maturation and function (PubMed:26385063). {ECO:0000269|PubMed:1732739, ECO:0000269|PubMed:22565310, ECO:0000269|PubMed:26385063, ECO:0000269|PubMed:7925301, ECO:0000269|PubMed:8441398}. |
| Q01484 | ANK2 | S2666 | ochoa | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}. |
| Q02224 | CENPE | S454 | ochoa | Centromere-associated protein E (Centromere protein E) (CENP-E) (Kinesin-7) (Kinesin-related protein CENPE) | Microtubule plus-end-directed kinetochore motor which plays an important role in chromosome congression, microtubule-kinetochore conjugation and spindle assembly checkpoint activation. Drives chromosome congression (alignment of chromosomes at the spindle equator resulting in the formation of the metaphase plate) by mediating the lateral sliding of polar chromosomes along spindle microtubules towards the spindle equator and by aiding the establishment and maintenance of connections between kinetochores and spindle microtubules (PubMed:23891108, PubMed:25395579, PubMed:7889940). The transport of pole-proximal chromosomes towards the spindle equator is favored by microtubule tracks that are detyrosinated (PubMed:25908662). Acts as a processive bi-directional tracker of dynamic microtubule tips; after chromosomes have congressed, continues to play an active role at kinetochores, enhancing their links with dynamic microtubule ends (PubMed:23955301). Suppresses chromosome congression in NDC80-depleted cells and contributes positively to congression only when microtubules are stabilized (PubMed:25743205). Plays an important role in the formation of stable attachments between kinetochores and spindle microtubules (PubMed:17535814) The stabilization of kinetochore-microtubule attachment also requires CENPE-dependent localization of other proteins to the kinetochore including BUB1B, MAD1 and MAD2. Plays a role in spindle assembly checkpoint activation (SAC) via its interaction with BUB1B resulting in the activation of its kinase activity, which is important for activating SAC. Necessary for the mitotic checkpoint signal at individual kinetochores to prevent aneuploidy due to single chromosome loss (By similarity). {ECO:0000250|UniProtKB:Q6RT24, ECO:0000269|PubMed:17535814, ECO:0000269|PubMed:23891108, ECO:0000269|PubMed:23955301, ECO:0000269|PubMed:25395579, ECO:0000269|PubMed:25743205, ECO:0000269|PubMed:25908662, ECO:0000269|PubMed:7889940}. |
| Q07617 | SPAG1 | S560 | ochoa | Sperm-associated antigen 1 (HSD-3.8) (Infertility-related sperm protein Spag-1) | May play a role in the cytoplasmic assembly of the ciliary dynein arms (By similarity). May play a role in fertilization. Binds GTP and has GTPase activity. {ECO:0000250, ECO:0000269|PubMed:11517287, ECO:0000269|PubMed:1299558}. |
| Q08945 | SSRP1 | S652 | ochoa | FACT complex subunit SSRP1 (Chromatin-specific transcription elongation factor 80 kDa subunit) (Facilitates chromatin transcription complex 80 kDa subunit) (FACT 80 kDa subunit) (FACTp80) (Facilitates chromatin transcription complex subunit SSRP1) (Recombination signal sequence recognition protein 1) (Structure-specific recognition protein 1) (hSSRP1) (T160) | Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63. {ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:12374749, ECO:0000269|PubMed:12934006, ECO:0000269|PubMed:16713563, ECO:0000269|PubMed:9489704, ECO:0000269|PubMed:9566881, ECO:0000269|PubMed:9836642}. |
| Q09666 | AHNAK | S5669 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q0VF96 | CGNL1 | S415 | ochoa | Cingulin-like protein 1 (Junction-associated coiled-coil protein) (Paracingulin) | May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons. {ECO:0000269|PubMed:22891260}. |
| Q12888 | TP53BP1 | S280 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12923 | PTPN13 | S969 | ochoa | Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1) (PTP-BAS) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (Protein-tyrosine phosphatase PTPL1) | Tyrosine phosphatase which negatively regulates FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317). {ECO:0000269|PubMed:15611135, ECO:0000269|PubMed:23604317}. |
| Q12959 | DLG1 | S138 | ochoa | Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (SAP97) (hDlg) | Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). May also play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel. During long-term depression in hippocampal neurons, it recruits ADAM10 to the plasma membrane (PubMed:23676497). {ECO:0000250|UniProtKB:A0A8C0TYJ0, ECO:0000250|UniProtKB:Q811D0, ECO:0000269|PubMed:10656683, ECO:0000269|PubMed:12445884, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15263016, ECO:0000269|PubMed:19213956, ECO:0000269|PubMed:20605917, ECO:0000269|PubMed:23676497}. |
| Q13464 | ROCK1 | S1147 | ochoa | Rho-associated protein kinase 1 (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-35) (Rho-associated, coiled-coil-containing protein kinase 1) (Rho-associated, coiled-coil-containing protein kinase I) (ROCK-I) (p160 ROCK-1) (p160ROCK) | Protein kinase which is a key regulator of the actin cytoskeleton and cell polarity (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:8617235, PubMed:9722579). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:23093407, PubMed:23355470, PubMed:8617235, PubMed:9722579). Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing (PubMed:18694941). Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (PubMed:19036714). Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability (By similarity). Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation (PubMed:19181962). Required for centrosome positioning and centrosome-dependent exit from mitosis (By similarity). Plays a role in terminal erythroid differentiation (PubMed:21072057). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Promotes keratinocyte terminal differentiation (PubMed:19997641). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles (By similarity). {ECO:0000250|UniProtKB:P70335, ECO:0000250|UniProtKB:Q8MIT6, ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:10652353, ECO:0000269|PubMed:11018042, ECO:0000269|PubMed:11283607, ECO:0000269|PubMed:17158456, ECO:0000269|PubMed:18573880, ECO:0000269|PubMed:18694941, ECO:0000269|PubMed:19036714, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19181962, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21072057, ECO:0000269|PubMed:23093407, ECO:0000269|PubMed:23355470, ECO:0000269|PubMed:8617235, ECO:0000269|PubMed:9722579}. |
| Q14690 | PDCD11 | S180 | ochoa | Protein RRP5 homolog (NF-kappa-B-binding protein) (NFBP) (Programmed cell death protein 11) | Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA. {ECO:0000269|PubMed:17654514}.; FUNCTION: Involved in the biogenesis of rRNA. {ECO:0000250}. |
| Q14980 | NUMA1 | S1942 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q15022 | SUZ12 | S568 | ochoa | Polycomb protein SUZ12 (Chromatin precipitated E2F target 9 protein) (ChET 9 protein) (Joined to JAZF1 protein) (Suppressor of zeste 12 protein homolog) | Polycomb group (PcG) protein. Component of the PRC2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:15231737, PubMed:15385962, PubMed:16618801, PubMed:17344414, PubMed:18285464, PubMed:28229514, PubMed:29499137, PubMed:31959557). The PRC2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (PubMed:12351676, PubMed:12435631, PubMed:15099518, PubMed:15225548, PubMed:15385962, PubMed:15684044, PubMed:16431907, PubMed:18086877, PubMed:18285464). Genes repressed by the PRC2 complex include HOXC8, HOXA9, MYT1 and CDKN2A (PubMed:15231737, PubMed:16618801, PubMed:17200670, PubMed:31959557). {ECO:0000269|PubMed:12351676, ECO:0000269|PubMed:12435631, ECO:0000269|PubMed:15099518, ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15385962, ECO:0000269|PubMed:15684044, ECO:0000269|PubMed:16431907, ECO:0000269|PubMed:16618801, ECO:0000269|PubMed:17200670, ECO:0000269|PubMed:17344414, ECO:0000269|PubMed:18086877, ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:28229514, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}. |
| Q15043 | SLC39A14 | S311 | ochoa | Metal cation symporter ZIP14 (LIV-1 subfamily of ZIP zinc transporter 4) (LZT-Hs4) (Solute carrier family 39 member 14) (Zrt- and Irt-like protein 14) (ZIP-14) | Electroneutral transporter of the plasma membrane mediating the cellular uptake of the divalent metal cations zinc, manganese and iron that are important for tissue homeostasis, metabolism, development and immunity (PubMed:15642354, PubMed:27231142, PubMed:29621230). Functions as an energy-dependent symporter, transporting through the membranes an electroneutral complex composed of a divalent metal cation and two bicarbonate anions (By similarity). Beside these endogenous cellular substrates, can also import cadmium a non-essential metal which is cytotoxic and carcinogenic (By similarity). Controls the cellular uptake by the intestinal epithelium of systemic zinc, which is in turn required to maintain tight junctions and the intestinal permeability (By similarity). Modifies the activity of zinc-dependent phosphodiesterases, thereby indirectly regulating G protein-coupled receptor signaling pathways important for gluconeogenesis and chondrocyte differentiation (By similarity). Regulates insulin receptor signaling, glucose uptake, glycogen synthesis and gluconeogenesis in hepatocytes through the zinc-dependent intracellular catabolism of insulin (PubMed:27703010). Through zinc cellular uptake also plays a role in the adaptation of cells to endoplasmic reticulum stress (By similarity). Major manganese transporter of the basolateral membrane of intestinal epithelial cells, it plays a central role in manganese systemic homeostasis through intestinal manganese uptake (PubMed:31028174). Also involved in manganese extracellular uptake by cells of the blood-brain barrier (PubMed:31699897). May also play a role in manganese and zinc homeostasis participating in their elimination from the blood through the hepatobiliary excretion (By similarity). Also functions in the extracellular uptake of free iron. May also function intracellularly and mediate the transport from endosomes to cytosol of iron endocytosed by transferrin (PubMed:20682781). Plays a role in innate immunity by regulating the expression of cytokines by activated macrophages (PubMed:23052185). {ECO:0000250|UniProtKB:Q75N73, ECO:0000269|PubMed:15642354, ECO:0000269|PubMed:20682781, ECO:0000269|PubMed:23052185, ECO:0000269|PubMed:27231142, ECO:0000269|PubMed:27703010, ECO:0000269|PubMed:29621230, ECO:0000269|PubMed:31028174, ECO:0000269|PubMed:31699897}. |
| Q15645 | TRIP13 | S41 | ochoa | Pachytene checkpoint protein 2 homolog (Human papillomavirus type 16 E1 protein-binding protein) (16E1-BP) (HPV16 E1 protein-binding protein) (Thyroid hormone receptor interactor 13) (Thyroid receptor-interacting protein 13) (TR-interacting protein 13) (TRIP-13) | Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double-strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes (By similarity). Plays a role in mitotic spindle assembly checkpoint (SAC) activation (PubMed:28553959). {ECO:0000250|UniProtKB:Q3UA06, ECO:0000269|PubMed:28553959}. |
| Q15652 | JMJD1C | S1228 | ochoa | Probable JmjC domain-containing histone demethylation protein 2C (EC 1.14.11.-) (Jumonji domain-containing protein 1C) (Thyroid receptor-interacting protein 8) (TR-interacting protein 8) (TRIP-8) | Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity). {ECO:0000250}. |
| Q16236 | NFE2L2 | S344 | psp | Nuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2) (NFE2-related factor 2) (Nrf-2) (Nuclear factor, erythroid derived 2, like 2) | Transcription factor that plays a key role in the response to oxidative stress: binds to antioxidant response (ARE) elements present in the promoter region of many cytoprotective genes, such as phase 2 detoxifying enzymes, and promotes their expression, thereby neutralizing reactive electrophiles (PubMed:11035812, PubMed:19489739, PubMed:29018201, PubMed:31398338). In normal conditions, ubiquitinated and degraded in the cytoplasm by the BCR(KEAP1) complex (PubMed:11035812, PubMed:15601839, PubMed:29018201). In response to oxidative stress, electrophile metabolites inhibit activity of the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2/NRF2, heterodimerization with one of the small Maf proteins and binding to ARE elements of cytoprotective target genes (PubMed:19489739, PubMed:29590092). The NFE2L2/NRF2 pathway is also activated in response to selective autophagy: autophagy promotes interaction between KEAP1 and SQSTM1/p62 and subsequent inactivation of the BCR(KEAP1) complex, leading to NFE2L2/NRF2 nuclear accumulation and expression of cytoprotective genes (PubMed:20452972). The NFE2L2/NRF2 pathway is also activated during the unfolded protein response (UPR), contributing to redox homeostasis and cell survival following endoplasmic reticulum stress (By similarity). May also be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region (PubMed:7937919). Also plays an important role in the regulation of the innate immune response and antiviral cytosolic DNA sensing. It is a critical regulator of the innate immune response and survival during sepsis by maintaining redox homeostasis and restraint of the dysregulation of pro-inflammatory signaling pathways like MyD88-dependent and -independent and TNF-alpha signaling (By similarity). Suppresses macrophage inflammatory response by blocking pro-inflammatory cytokine transcription and the induction of IL6 (By similarity). Binds to the proximity of pro-inflammatory genes in macrophages and inhibits RNA Pol II recruitment. The inhibition is independent of the NRF2-binding motif and reactive oxygen species level (By similarity). Represses antiviral cytosolic DNA sensing by suppressing the expression of the adapter protein STING1 and decreasing responsiveness to STING1 agonists while increasing susceptibility to infection with DNA viruses (PubMed:30158636). Once activated, limits the release of pro-inflammatory cytokines in response to human coronavirus SARS-CoV-2 infection and to virus-derived ligands through a mechanism that involves inhibition of IRF3 dimerization. Also inhibits both SARS-CoV-2 replication, as well as the replication of several other pathogenic viruses including Herpes Simplex Virus-1 and-2, Vaccinia virus, and Zika virus through a type I interferon (IFN)-independent mechanism (PubMed:33009401). {ECO:0000250|UniProtKB:Q60795, ECO:0000269|PubMed:11035812, ECO:0000269|PubMed:15601839, ECO:0000269|PubMed:19489739, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:29018201, ECO:0000269|PubMed:29590092, ECO:0000269|PubMed:30158636, ECO:0000269|PubMed:31398338, ECO:0000269|PubMed:33009401, ECO:0000269|PubMed:7937919}. |
| Q16659 | MAPK6 | S558 | ochoa | Mitogen-activated protein kinase 6 (MAP kinase 6) (MAPK 6) (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97-MAPK) | Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity). {ECO:0000250}. |
| Q2KJY2 | KIF26B | S984 | ochoa | Kinesin-like protein KIF26B | Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity). {ECO:0000250}. |
| Q2M1Z3 | ARHGAP31 | S595 | ochoa | Rho GTPase-activating protein 31 (Cdc42 GTPase-activating protein) | Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading, polarized lamellipodia formation and cell migration. {ECO:0000269|PubMed:12192056, ECO:0000269|PubMed:16519628}. |
| Q2PPJ7 | RALGAPA2 | S368 | ochoa | Ral GTPase-activating protein subunit alpha-2 (250 kDa substrate of Akt) (AS250) (p220) | Catalytic subunit of the heterodimeric RalGAP2 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. {ECO:0000250}. |
| Q5DJT8 | CT45A2 | S103 | ochoa | Cancer/testis antigen family 45 member A2 (Cancer/testis antigen 45-2) (Cancer/testis antigen 45A2) | None |
| Q5FBB7 | SGO1 | S129 | ochoa | Shugoshin 1 (Serologically defined breast cancer antigen NY-BR-85) (Shugoshin-like 1) | Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity. Involved in centromeric enrichment of AUKRB in prometaphase. {ECO:0000269|PubMed:15604152, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:15737064, ECO:0000269|PubMed:16580887, ECO:0000269|PubMed:17617734, ECO:0000269|PubMed:17621308, ECO:0000269|PubMed:18331714, ECO:0000269|PubMed:20739936}. |
| Q5HYN5 | CT45A1 | S103 | ochoa | Cancer/testis antigen family 45 member A1 (Cancer/testis antigen 45-1) (Cancer/testis antigen 45A1) | None |
| Q5T3J3 | LRIF1 | S599 | ochoa | Ligand-dependent nuclear receptor-interacting factor 1 (HP1-binding protein enriched in inactive X chromosome protein 1) (HBiX1) (Receptor-interacting factor 1) | Together with SMCHD1, involved in chromosome X inactivation in females by promoting the compaction of heterochromatin (PubMed:23542155). Also able to repress the ligand-induced transcriptional activity of retinoic acid receptor alpha (RARA), possibly through direct recruitment of histone deacetylases (PubMed:17455211). Also required for silencing of the DUX4 locus in somatic cells (PubMed:32467133). {ECO:0000269|PubMed:17455211, ECO:0000269|PubMed:23542155, ECO:0000269|PubMed:32467133}. |
| Q5T481 | RBM20 | S980 | ochoa | RNA-binding protein 20 (RNA-binding motif protein 20) | RNA-binding protein that acts as a regulator of mRNA splicing of a subset of genes encoding key structural proteins involved in cardiac development, such as TTN (Titin), CACNA1C, CAMK2D or PDLIM5/ENH (PubMed:22466703, PubMed:24960161, PubMed:26604136, PubMed:27496873, PubMed:27531932, PubMed:29895960, PubMed:30948719, PubMed:32840935, PubMed:34732726, PubMed:35427468). Acts as a repressor of mRNA splicing: specifically binds the 5'UCUU-3' motif that is predominantly found within intronic sequences of pre-mRNAs, leading to the exclusion of specific exons in target transcripts (PubMed:24960161, PubMed:30948719, PubMed:34732726). RBM20-mediated exon skipping is hormone-dependent and is essential for TTN isoform transition in both cardiac and skeletal muscles (PubMed:27531932, PubMed:30948719). RBM20-mediated exon skipping of TTN provides substrates for the formation of circular RNA (circRNAs) from the TTN transcripts (PubMed:27531932, PubMed:34732726). Together with RBM24, promotes the expression of short isoforms of PDLIM5/ENH in cardiomyocytes (By similarity). {ECO:0000250|UniProtKB:E9PT37, ECO:0000269|PubMed:22466703, ECO:0000269|PubMed:24960161, ECO:0000269|PubMed:26604136, ECO:0000269|PubMed:27496873, ECO:0000269|PubMed:27531932, ECO:0000269|PubMed:29895960, ECO:0000269|PubMed:30948719, ECO:0000269|PubMed:32840935, ECO:0000269|PubMed:34732726, ECO:0000269|PubMed:35427468}. |
| Q5UIP0 | RIF1 | S1971 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5W0B1 | OBI1 | S75 | ochoa | ORC ubiquitin ligase 1 (OBI1) (EC 2.3.2.27) (RING finger protein 219) | E3 ubiquitin ligase essential for DNA replication origin activation during S phase (PubMed:31160578). Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase (PubMed:31160578). {ECO:0000269|PubMed:31160578}. |
| Q6P0N0 | MIS18BP1 | S991 | ochoa | Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243) | Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038, ECO:0000269|PubMed:17339379}. |
| Q6PJW8 | CNST | S293 | ochoa | Consortin | Required for targeting of connexins to the plasma membrane. {ECO:0000269|PubMed:19864490}. |
| Q6PL18 | ATAD2 | S1233 | ochoa | ATPase family AAA domain-containing protein 2 (EC 3.6.1.-) (AAA nuclear coregulator cancer-associated protein) (ANCCA) | May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells. {ECO:0000269|PubMed:17998543}. |
| Q6UN15 | FIP1L1 | S440 | ochoa | Pre-mRNA 3'-end-processing factor FIP1 (hFip1) (FIP1-like 1 protein) (Factor interacting with PAP) (Rearranged in hypereosinophilia) | Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex. {ECO:0000269|PubMed:14749727}. |
| Q6WKZ4 | RAB11FIP1 | S500 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
| Q6ZS30 | NBEAL1 | S1842 | ochoa | Neurobeachin-like protein 1 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 16 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 17 protein) | None |
| Q6ZUT9 | DENND5B | S1076 | ochoa | DENN domain-containing protein 5B (Rab6IP1-like protein) | Guanine nucleotide exchange factor (GEF) which may activate RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}. |
| Q6ZV89 | SH2D5 | S197 | ochoa | SH2 domain-containing protein 5 | May be involved in synaptic plasticity regulation through the control of Rac-GTP levels. {ECO:0000250|UniProtKB:Q8JZW5}. |
| Q7L2H7 | EIF3M | S152 | ochoa | Eukaryotic translation initiation factor 3 subunit M (eIF3m) (Fetal lung protein B5) (hFL-B5) (PCI domain-containing protein 1) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17403899, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17403899). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03012, ECO:0000269|PubMed:17403899, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) May favor virus entry in case of infection with herpes simplex virus 1 (HSV1) or herpes simplex virus 2 (HSV2). {ECO:0000269|PubMed:15919898}. |
| Q7L9B9 | EEPD1 | S149 | ochoa | Endonuclease/exonuclease/phosphatase family domain-containing protein 1 | None |
| Q7Z2Z1 | TICRR | S1840 | ochoa | Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) | Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}. |
| Q7Z309 | PABIR2 | S55 | ochoa | PABIR family member 2 | None |
| Q7Z3G6 | PRICKLE2 | S753 | ochoa | Prickle-like protein 2 | None |
| Q7Z401 | DENND4A | S963 | ochoa | C-myc promoter-binding protein (DENN domain-containing protein 4A) | Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter. {ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:8056341}. |
| Q7Z5K2 | WAPL | S159 | ochoa | Wings apart-like protein homolog (Friend of EBNA2 protein) (WAPL cohesin release factor) | Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin (PubMed:26299517). Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15150110, ECO:0000269|PubMed:17112726, ECO:0000269|PubMed:17113138, ECO:0000269|PubMed:19696148, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:21111234, ECO:0000269|PubMed:23776203, ECO:0000269|PubMed:26299517}. |
| Q86UU1 | PHLDB1 | S563 | ochoa | Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha) | None |
| Q86WJ1 | CHD1L | S591 | ochoa | Chromodomain-helicase-DNA-binding protein 1-like (EC 3.6.4.-) (Amplified in liver cancer protein 1) | ATP-dependent chromatin remodeler that mediates chromatin-remodeling following DNA damage (PubMed:19661379, PubMed:29220652, PubMed:29220653, PubMed:33357431, PubMed:34210977, PubMed:34486521, PubMed:34874266). Recruited to DNA damage sites through interaction with poly-ADP-ribose: specifically recognizes and binds histones that are poly-ADP-ribosylated on serine residues in response to DNA damage (PubMed:19661379, PubMed:29220652, PubMed:29220653, PubMed:34486521, PubMed:34874266). Poly-ADP-ribose-binding activates the ATP-dependent chromatin remodeler activity, thereby regulating chromatin during DNA repair (PubMed:19661379, PubMed:29220652, PubMed:29220653, PubMed:34486521, PubMed:34874266). Catalyzes nucleosome sliding away from DNA breaks in an ATP-dependent manner (PubMed:19661379, PubMed:29220652, PubMed:29220653). Chromatin remodeling activity promotes PARP2 removal from chromatin (PubMed:33275888). {ECO:0000269|PubMed:19661379, ECO:0000269|PubMed:29220652, ECO:0000269|PubMed:29220653, ECO:0000269|PubMed:33275888, ECO:0000269|PubMed:33357431, ECO:0000269|PubMed:34210977, ECO:0000269|PubMed:34486521, ECO:0000269|PubMed:34874266}. |
| Q86YS3 | RAB11FIP4 | S324 | ochoa | Rab11 family-interacting protein 4 (FIP4-Rab11) (Rab11-FIP4) (Arfophilin-2) | Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abscission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. In case of infection by HCMV (human cytomegalovirus), may participate in egress of the virus out of nucleus; this function is independent of ARF6. {ECO:0000269|PubMed:12470645}. |
| Q8IUG5 | MYO18B | S2350 | ochoa | Unconventional myosin-XVIIIb | May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth. |
| Q8IVE3 | PLEKHH2 | S1458 | ochoa | Pleckstrin homology domain-containing family H member 2 | In the kidney glomerulus may play a role in linking podocyte foot processes to the glomerular basement membrane. May be involved in stabilization of F-actin by attenuating its depolymerization. Can recruit TGFB1I1 from focal adhesions to podocyte lamellipodia. |
| Q8IWB9 | TEX2 | S398 | ochoa | Testis-expressed protein 2 (Transmembrane protein 96) | During endoplasmic reticulum (ER) stress or when cellular ceramide levels increase, may induce contacts between the ER and medial-Golgi complex to facilitate non-vesicular transport of ceramides from the ER to the Golgi complex where they are converted to complex sphingolipids, preventing toxic ceramide accumulation. {ECO:0000269|PubMed:28011845}. |
| Q8IXJ9 | ASXL1 | S462 | ochoa | Polycomb group protein ASXL1 (Additional sex combs-like protein 1) | Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG) (PubMed:16606617). Acts as a coactivator of RARA and RXRA through association with NCOA1 (PubMed:16606617). Acts as a corepressor for PPARG and suppresses its adipocyte differentiation-inducing activity (By similarity). Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (PubMed:20436459, PubMed:30664650, PubMed:36180891). Acts as a sensor of N(6)-methyladenine methylation on DNA (6mA): recognizes and binds 6mA DNA, leading to its ubiquitination and degradation by TRIP12, thereby inactivating the PR-DUB complex and regulating Polycomb silencing (PubMed:30982744). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:30664650, PubMed:36180891). ASXL1, ASXL2 and ASXL3 function redundantly in the PR-DUB complex (By similarity) (PubMed:30664650). The ASXL proteins are essential for chromatin recruitment and transcriptional activation of associated genes (By similarity). ASXL1 and ASXL2 are important for BAP1 protein stability (PubMed:30664650). Together with BAP1, negatively regulates epithelial-mesenchymal transition (EMT) of trophoblast stem cells during placental development by regulating genes involved in epithelial cell integrity, cell adhesion and cytoskeletal organization (PubMed:34170818). {ECO:0000250|UniProtKB:P59598, ECO:0000269|PubMed:16606617, ECO:0000269|PubMed:20436459, ECO:0000269|PubMed:30664650, ECO:0000269|PubMed:30982744, ECO:0000269|PubMed:34170818, ECO:0000269|PubMed:36180891}. |
| Q8IZD4 | DCP1B | S227 | ochoa | mRNA-decapping enzyme 1B (EC 3.6.1.62) | May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (By similarity). {ECO:0000250|UniProtKB:Q9NPI6}. |
| Q8IZH2 | XRN1 | S1045 | ochoa | 5'-3' exoribonuclease 1 (EC 3.1.13.-) (Strand-exchange protein 1 homolog) | Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS). {ECO:0000250|UniProtKB:P97789, ECO:0000269|PubMed:18172165}. |
| Q8N163 | CCAR2 | S23 | ochoa | Cell cycle and apoptosis regulator protein 2 (Cell division cycle and apoptosis regulator protein 2) (DBIRD complex subunit KIAA1967) (Deleted in breast cancer gene 1 protein) (DBC-1) (DBC.1) (NET35) (p30 DBC) | Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions (PubMed:22446626). Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis (PubMed:18235501, PubMed:18235502, PubMed:23352644). Inhibits SUV39H1 methyltransferase activity (PubMed:19218236). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress (PubMed:23398316). Regulates the circadian expression of the core clock components NR1D1 and BMAL1 (PubMed:23398316). Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation (PubMed:23398316). Represses the ligand-dependent transcriptional activation function of ESR2 (PubMed:20074560). Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 (PubMed:24415752). Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization (PubMed:21030595). Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway (PubMed:24824780). Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (PubMed:25661920). Plays an important role in tumor suppression through p53/TP53 regulation; stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 (PubMed:25732823). Represses the transcriptional activator activity of BRCA1 (PubMed:20160719). Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro (PubMed:25361978). {ECO:0000269|PubMed:18235501, ECO:0000269|PubMed:18235502, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19218236, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:22446626, ECO:0000269|PubMed:23352644, ECO:0000269|PubMed:23398316, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25661920, ECO:0000269|PubMed:25732823}. |
| Q8N4C6 | NIN | S1837 | ochoa | Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein) | Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells (PubMed:15190203, PubMed:23386061). May also act as a centrosome maturation factor (PubMed:11956314). May play a role in microtubule nucleation, by recruiting the gamma-tubulin ring complex to the centrosome (PubMed:15190203). Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules (PubMed:15190203). Required for centriole organization and microtubule anchoring at the mother centriole (PubMed:23386061). {ECO:0000269|PubMed:11956314, ECO:0000269|PubMed:15190203, ECO:0000269|PubMed:23386061}. |
| Q8ND24 | RNF214 | S195 | ochoa | RING finger protein 214 | None |
| Q8NEN9 | PDZD8 | S530 | ochoa | PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR-104) | Molecular tethering protein that connects endoplasmic reticulum and mitochondria membranes (PubMed:29097544). PDZD8-dependent endoplasmic reticulum-mitochondria membrane tethering is essential for endoplasmic reticulum-mitochondria Ca(2+) transfer (PubMed:29097544). In neurons, involved in the regulation of dendritic Ca(2+) dynamics by regulating mitochondrial Ca(2+) uptake in neurons (PubMed:29097544). Plays an indirect role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987). May inhibit herpes simplex virus 1 infection at an early stage (PubMed:21549406). {ECO:0000269|PubMed:21549406, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:29097544}. |
| Q8NHU0 | CT45A3 | S103 | ochoa | Cancer/testis antigen family 45 member A3 (Cancer/testis antigen 45-3) (Cancer/testis antigen 45-4) (Cancer/testis antigen 45A3) (Cancer/testis antigen 45A4) (Cancer/testis antigen family 45 member A4) | None |
| Q8TBZ8 | ZNF564 | S183 | ochoa | Zinc finger protein 564 | May be involved in transcriptional regulation. |
| Q8TDJ6 | DMXL2 | S929 | ochoa | DmX-like protein 2 (Rabconnectin-3) | May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles (PubMed:11809763). Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity). {ECO:0000250|UniProtKB:Q8BPN8, ECO:0000269|PubMed:11809763}. |
| Q8WX93 | PALLD | S595 | ochoa | Palladin (SIH002) (Sarcoma antigen NY-SAR-77) | Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. {ECO:0000269|PubMed:11598191, ECO:0000269|PubMed:15147863, ECO:0000269|PubMed:17537434}. |
| Q8WYL5 | SSH1 | S812 | ochoa | Protein phosphatase Slingshot homolog 1 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 1) (SSH-1L) (hSSH-1L) | Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. {ECO:0000269|PubMed:11832213, ECO:0000269|PubMed:12684437, ECO:0000269|PubMed:12807904, ECO:0000269|PubMed:14531860, ECO:0000269|PubMed:14645219, ECO:0000269|PubMed:15056216, ECO:0000269|PubMed:15159416, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:15671020, ECO:0000269|PubMed:16230460}. |
| Q8WZ82 | OVCA2 | S168 | ochoa | Esterase OVCA2 (EC 3.1.1.1) (OVCA2 serine hydrolase domain-containing protein) (Ovarian cancer-associated gene 2 protein) | Exhibits ester hydrolase activity with a strong preference for long-chain alkyl ester substrates and high selectivity against a variety of short, branched, and substituted esters. Is able to hydrolyze ester bonds within a wide range of p-nitrophenyl derivatives (C2-C14) in vitro, with a strong preference toward substrates of >8 carbons. {ECO:0000269|PubMed:32182256}. |
| Q92900 | UPF1 | S1084 | psp | Regulator of nonsense transcripts 1 (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent helicase RENT1) (Nonsense mRNA reducing factor 1) (NORF1) (Up-frameshift suppressor 1 homolog) (hUpf1) | RNA-dependent helicase required for nonsense-mediated decay (NMD) of aberrant mRNAs containing premature stop codons and modulates the expression level of normal mRNAs (PubMed:11163187, PubMed:16086026, PubMed:18172165, PubMed:21145460, PubMed:21419344, PubMed:24726324). Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD (PubMed:11544179, PubMed:25220460). Recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex (PubMed:19417104). In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) (located 50-55 or more nucleotides downstream from the termination codon) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD (PubMed:21419344). Phosphorylated UPF1 is recognized by EST1B/SMG5, SMG6 and SMG7 which are thought to provide a link to the mRNA degradation machinery involving exonucleolytic and endonucleolytic pathways, and to serve as adapters to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation and allowing the recycling of NMD factors (PubMed:12554878). UPF1 can also activate NMD without UPF2 or UPF3, and in the absence of the NMD-enhancing downstream EJC indicative for alternative NMD pathways (PubMed:18447585). Plays a role in replication-dependent histone mRNA degradation at the end of phase S; the function is independent of UPF2 (PubMed:16086026, PubMed:18172165). For the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed (PubMed:18447585, PubMed:25220460). The ATPase activity of UPF1 is required for disassembly of mRNPs undergoing NMD (PubMed:21145460). Together with UPF2 and dependent on TDRD6, mediates the degradation of mRNA harboring long 3'UTR by inducing the NMD machinery (By similarity). Also capable of unwinding double-stranded DNA and translocating on single-stranded DNA (PubMed:30218034). {ECO:0000250|UniProtKB:Q9EPU0, ECO:0000269|PubMed:11163187, ECO:0000269|PubMed:11544179, ECO:0000269|PubMed:12554878, ECO:0000269|PubMed:16086026, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:18447585, ECO:0000269|PubMed:19417104, ECO:0000269|PubMed:21145460, ECO:0000269|PubMed:21419344, ECO:0000269|PubMed:24726324, ECO:0000269|PubMed:25220460, ECO:0000269|PubMed:30218034}. |
| Q96B97 | SH3KBP1 | S79 | ochoa | SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1) | Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may be inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Has an essential role in the stimulation of B cell activation (PubMed:29636373). {ECO:0000250, ECO:0000269|PubMed:11894095, ECO:0000269|PubMed:11894096, ECO:0000269|PubMed:12177062, ECO:0000269|PubMed:12734385, ECO:0000269|PubMed:12771190, ECO:0000269|PubMed:15090612, ECO:0000269|PubMed:15707590, ECO:0000269|PubMed:16177060, ECO:0000269|PubMed:16256071, ECO:0000269|PubMed:21275903, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:29636373}. |
| Q96G27 | WBP1 | S212 | ochoa | WW domain-binding protein 1 (WBP-1) | None |
| Q96H22 | CENPN | S218 | ochoa | Centromere protein N (CENP-N) (Interphase centromere complex protein 32) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA nucleosomes by CENPN is required for centromere assembly. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate. {ECO:0000269|PubMed:16622419, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:18007590, ECO:0000269|PubMed:19543270}. |
| Q96KR1 | ZFR | S553 | ochoa | Zinc finger RNA-binding protein (hZFR) (M-phase phosphoprotein homolog) | Involved in postimplantation and gastrulation stages of development. Involved in the nucleocytoplasmic shuttling of STAU2. Binds to DNA and RNA (By similarity). {ECO:0000250}. |
| Q96L93 | KIF16B | S587 | ochoa | Kinesin-like protein KIF16B (Sorting nexin-23) | Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. {ECO:0000269|PubMed:15882625}. |
| Q96MK2 | RIPOR3 | S384 | ochoa | RIPOR family member 3 | None |
| Q96PU5 | NEDD4L | S538 | ochoa | E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2) | E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins and is thereby implicated in the regulation of various signaling pathways including autophagy, innate immunity or DNA repair (PubMed:20064473, PubMed:31959741, PubMed:33608556). Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation (PubMed:15496141). Downregulates autophagy and cell growth by ubiquitinating and reducing cellular ULK1 or ASCT2 levels (PubMed:28820317, PubMed:31959741). Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5 (PubMed:26363003, PubMed:27445338). Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Involved in the regulation of TOR signaling (PubMed:27694961). Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF (PubMed:27445338). Plays a role in antiviral innate immunity by catalyzing 'Lys-29'-linked cysteine ubiquitination of TRAF3, resulting in enhanced 'Lys-48' and 'Lys-63'-linked ubiquitination of TRAF3 (PubMed:33608556). Ubiquitinates TTYH2 and TTYH3 and regulates protein levels of TTYH2 (PubMed:18577513). {ECO:0000250|UniProtKB:Q8CFI0, ECO:0000269|PubMed:12911626, ECO:0000269|PubMed:15040001, ECO:0000269|PubMed:15217910, ECO:0000269|PubMed:15489223, ECO:0000269|PubMed:15496141, ECO:0000269|PubMed:15576372, ECO:0000269|PubMed:18577513, ECO:0000269|PubMed:19144635, ECO:0000269|PubMed:23999003, ECO:0000269|PubMed:25631046, ECO:0000269|PubMed:26363003, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:27694961, ECO:0000269|PubMed:33608556}. |
| Q96Q89 | KIF20B | S1756 | ochoa | Kinesin-like protein KIF20B (Cancer/testis antigen 90) (CT90) (Kinesin family member 20B) (Kinesin-related motor interacting with PIN1) (M-phase phosphoprotein 1) (MPP1) | Plus-end-directed motor enzyme that is required for completion of cytokinesis (PubMed:11470801, PubMed:12740395). Required for proper midbody organization and abscission in polarized cortical stem cells. Plays a role in the regulation of neuronal polarization by mediating the transport of specific cargos. Participates in the mobilization of SHTN1 and in the accumulation of PIP3 in the growth cone of primary hippocampal neurons in a tubulin and actin-dependent manner. In the developing telencephalon, cooperates with SHTN1 to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in cerebral cortex growth (By similarity). Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436). {ECO:0000250|UniProtKB:Q80WE4, ECO:0000269|PubMed:11470801, ECO:0000269|PubMed:12740395, ECO:0000269|PubMed:17409436}. |
| Q96R06 | SPAG5 | S954 | ochoa | Sperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126) | Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase (PubMed:11724960, PubMed:12356910, PubMed:27462074). Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:17664331, PubMed:27462074). In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes (PubMed:18361916, PubMed:21402792). Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis (PubMed:23953116). May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU (PubMed:18055457). {ECO:0000269|PubMed:12356910, ECO:0000269|PubMed:17664331, ECO:0000269|PubMed:18055457, ECO:0000269|PubMed:18361916, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:23953116, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:27462074, ECO:0000305|PubMed:11724960}. |
| Q96S59 | RANBP9 | S181 | psp | Ran-binding protein 9 (RanBP9) (BPM-L) (BPM90) (Ran-binding protein M) (RanBPM) (RanBP7) | May act as scaffolding protein, and as adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Acts as a mediator of cell spreading and actin cytoskeleton rearrangement (PubMed:18710924). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). May be involved in signaling of ITGB2/LFA-1 and other integrins (PubMed:14722085). Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway (PubMed:12147692). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation (PubMed:12361945, PubMed:18222118). Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity (PubMed:15558019). Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA. {ECO:0000269|PubMed:12147692, ECO:0000269|PubMed:12361945, ECO:0000269|PubMed:14500717, ECO:0000269|PubMed:14722085, ECO:0000269|PubMed:15381419, ECO:0000269|PubMed:15558019, ECO:0000269|PubMed:18222118, ECO:0000269|PubMed:18710924, ECO:0000269|PubMed:29911972, ECO:0000305}. |
| Q96TA1 | NIBAN2 | S574 | ochoa | Protein Niban 2 (Meg-3) (Melanoma invasion by ERK) (MINERVA) (Niban-like protein 1) (Protein FAM129B) | May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro. {ECO:0000269|PubMed:19362540, ECO:0000269|PubMed:21148485}. |
| Q99426 | TBCB | S91 | ochoa | Tubulin-folding cofactor B (Cytoskeleton-associated protein 1) (Cytoskeleton-associated protein CKAPI) (Tubulin-specific chaperone B) | Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer (PubMed:9265649). Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth (By similarity). {ECO:0000250|UniProtKB:Q9D1E6, ECO:0000269|PubMed:9265649}. |
| Q99570 | PIK3R4 | S925 | ochoa | Phosphoinositide 3-kinase regulatory subunit 4 (PI3-kinase regulatory subunit 4) (EC 2.7.11.1) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein) | Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123). {ECO:0000269|PubMed:20643123}. |
| Q99666 | RGPD5 | S1621 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q9BQK8 | LPIN3 | S463 | ochoa | Phosphatidate phosphatase LPIN3 (EC 3.1.3.4) (Lipin-3) (Lipin-3-like) | Magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis therefore regulates fatty acid metabolism. {ECO:0000250|UniProtKB:Q99PI4}. |
| Q9BRY0 | SLC39A3 | S114 | ochoa | Zinc transporter ZIP3 (Solute carrier family 39 member 3) (Zrt- and Irt-like protein 3) (ZIP-3) | Transporter for the divalent cation Zn(2+). Mediates the influx of Zn(2+) into cells from extracellular space. Controls Zn(2+) accumulation into dentate gyrus granule cells in the hippocampus. Mediates Zn(2+) reuptake from the secreted milk within the alveolar lumen. {ECO:0000250|UniProtKB:Q99K24}. |
| Q9BS34 | ZNF670 | S64 | ochoa | Zinc finger protein 670 | May be involved in transcriptional regulation. |
| Q9BVK6 | TMED9 | S162 | ochoa | Transmembrane emp24 domain-containing protein 9 (GMP25) (Glycoprotein 25L2) (p24 family protein alpha-2) (p24alpha2) (p25) | Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer-dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of the ER-Golgi intermediate compartment and the Golgi apparatus. Involved in ER localization of PTPN2 isoform PTPB. {ECO:0000269|PubMed:10852829, ECO:0000269|PubMed:14600267, ECO:0000269|PubMed:16595549, ECO:0000269|PubMed:18287528, ECO:0000269|PubMed:19296914}. |
| Q9H0M0 | WWP1 | S25 | ochoa | NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 2.3.2.26) (Atrophin-1-interacting protein 5) (AIP5) (HECT-type E3 ubiquitin transferase WWP1) (TGIF-interacting ubiquitin ligase 1) (Tiul1) (WW domain-containing protein 1) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF. Activates the Hippo signaling pathway in response to cell contact inhibition and recruitment to the Crumbs complex at the cell membrane (PubMed:34404733). Monoubiquitinates AMOTL2 which facilitates its interaction with and activation of LATS2 (PubMed:34404733). LATS2 then phosphorylates YAP1, excluding it from the nucleus and therefore ultimately represses YAP1-driven transcription of target genes (PubMed:34404733). {ECO:0000269|PubMed:12535537, ECO:0000269|PubMed:15221015, ECO:0000269|PubMed:15359284, ECO:0000269|PubMed:34404733}. |
| Q9H2C0 | GAN | S174 | ochoa | Gigaxonin (Kelch-like protein 16) | Probable cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Controls degradation of TBCB. Controls degradation of MAP1B and MAP1S, and is critical for neuronal maintenance and survival. {ECO:0000269|PubMed:12147674, ECO:0000269|PubMed:15983046, ECO:0000269|PubMed:16227972, ECO:0000269|PubMed:16303566}. |
| Q9H2E6 | SEMA6A | S760 | ochoa | Semaphorin-6A (Semaphorin VIA) (Sema VIA) (Semaphorin-6A-1) (SEMA6A-1) | Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation. {ECO:0000250|UniProtKB:O35464}.; FUNCTION: (Microbial infection) Acts as a receptor for P.sordellii toxin TcsL in the in the vascular endothelium. {ECO:0000269|PubMed:32302524, ECO:0000269|PubMed:32589945}. |
| Q9H3R0 | KDM4C | S198 | ochoa | Lysine-specific demethylase 4C (EC 1.14.11.66) (Gene amplified in squamous cell carcinoma 1 protein) (GASC-1 protein) (JmjC domain-containing histone demethylation protein 3C) (Jumonji domain-containing protein 2C) ([histone H3]-trimethyl-L-lysine(9) demethylase 4C) | Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. {ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:28262558}. |
| Q9H694 | BICC1 | S31 | ochoa | Protein bicaudal C homolog 1 (Bic-C) | Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development. {ECO:0000269|PubMed:21922595}. |
| Q9H706 | GAREM1 | S382 | ochoa | GRB2-associated and regulator of MAPK protein 1 (GRB2-associated and regulator of MAPK1) | [Isoform 1]: Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation. {ECO:0000269|PubMed:19509291}. |
| Q9HD42 | CHMP1A | S101 | ochoa | Charged multivesicular body protein 1a (Chromatin-modifying protein 1a) (CHMP1a) (Vacuolar protein sorting-associated protein 46-1) (Vps46-1) (hVps46-1) | Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing. {ECO:0000269|PubMed:11559747, ECO:0000269|PubMed:11559748, ECO:0000269|PubMed:19129479, ECO:0000269|PubMed:23045692}. |
| Q9NP62 | GCM1 | S177 | psp | Chorion-specific transcription factor GCMa (hGCMa) (GCM motif protein 1) (Glial cells missing homolog 1) | Transcription factor involved in the control of expression of placental growth factor (PGF) and other placenta-specific genes (PubMed:10542267, PubMed:18160678). Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer (PubMed:10542267). Binds to the SYDE1 promoter (PubMed:27917469). Has a central role in mediating the differentiation of trophoblast cells along both the villous and extravillous pathways in placental development (PubMed:19219068). {ECO:0000269|PubMed:10542267, ECO:0000269|PubMed:18160678, ECO:0000269|PubMed:19219068, ECO:0000269|PubMed:27917469}. |
| Q9NQ86 | TRIM36 | S279 | ochoa | E3 ubiquitin-protein ligase TRIM36 (EC 2.3.2.27) (RING finger protein 98) (RING-type E3 ubiquitin transferase TRIM36) (Tripartite motif-containing protein 36) (Zinc-binding protein Rbcc728) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation (PubMed:28087737). May play a role in the acrosome reaction and fertilization. {ECO:0000250|UniProtKB:Q80WG7, ECO:0000269|PubMed:28087737}. |
| Q9NR12 | PDLIM7 | S29 | ochoa | PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma) | May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity). {ECO:0000250, ECO:0000269|PubMed:11874232, ECO:0000269|PubMed:7929196}. |
| Q9NR82 | KCNQ5 | S831 | ochoa | Potassium voltage-gated channel subfamily KQT member 5 (KQT-like 5) (Potassium channel subunit alpha KvLQT5) (Voltage-gated potassium channel subunit Kv7.5) | Pore-forming subunit of the voltage-gated potassium (Kv) channel broadly expressed in brain and involved in the regulation of neuronal excitability (PubMed:10787416, PubMed:10816588, PubMed:11159685, PubMed:28669405). Associates with KCNQ3/Kv7.3 pore-forming subunit to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons (PubMed:10816588, PubMed:11159685). Contributes, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current (PubMed:10816588). Also forms a functional channel with KCNQ1/Kv7.1 subunit that may contribute to vasoconstriction and hypertension (PubMed:24855057). Channel may be selectively permeable in vitro to other cations besides potassium, in decreasing order of affinity K(+) = Rb(+) > Cs(+) > Na(+) (PubMed:10816588). Similar to the native M-channel, KCNQ3-KCNQ5 potassium channel is suppressed by activation of the muscarinic acetylcholine receptor CHRM1 (PubMed:10816588). {ECO:0000269|PubMed:10787416, ECO:0000269|PubMed:10816588, ECO:0000269|PubMed:11159685, ECO:0000269|PubMed:24855057, ECO:0000269|PubMed:28669405}. |
| Q9NS91 | RAD18 | S122 | ochoa | E3 ubiquitin-protein ligase RAD18 (EC 2.3.2.27) (Postreplication repair protein RAD18) (hHR18) (hRAD18) (RING finger protein 73) (RING-type E3 ubiquitin transferase RAD18) | E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity. {ECO:0000269|PubMed:17108083, ECO:0000269|PubMed:21659603}. |
| Q9NUW8 | TDP1 | S81 | psp | Tyrosyl-DNA phosphodiesterase 1 (Tyr-DNA phosphodiesterase 1) (EC 3.1.4.-) | DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate. {ECO:0000269|PubMed:12023295, ECO:0000269|PubMed:15111055, ECO:0000269|PubMed:15811850, ECO:0000269|PubMed:16141202, ECO:0000269|PubMed:22822062}. |
| Q9UBC2 | EPS15L1 | S49 | ochoa | Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) | Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:9407958}. |
| Q9UDY2 | TJP2 | S385 | ochoa | Tight junction protein 2 (Tight junction protein ZO-2) (Zona occludens protein 2) (Zonula occludens protein 2) | Plays a role in tight junctions and adherens junctions (By similarity). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (By similarity). {ECO:0000250|UniProtKB:Q9Z0U1}. |
| Q9UEW8 | STK39 | S370 | ochoa | STE20/SPS1-related proline-alanine-rich protein kinase (Ste-20-related kinase) (EC 2.7.11.1) (DCHT) (Serine/threonine-protein kinase 39) | Effector serine/threonine-protein kinase component of the WNK-SPAK/OSR1 kinase cascade, which is involved in various processes, such as ion transport, response to hypertonic stress and blood pressure (PubMed:16669787, PubMed:18270262, PubMed:21321328, PubMed:34289367). Specifically recognizes and binds proteins with a RFXV motif (PubMed:16669787, PubMed:21321328). Acts downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4): following activation by WNK kinases, catalyzes phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:21321328). Mediates regulatory volume increase in response to hyperosmotic stress by catalyzing phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1 and SLC12A6/KCC3 downstream of WNK1 and WNK3 kinases (PubMed:12740379, PubMed:16669787, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:16669787, PubMed:19665974, PubMed:21321328). Acts as a regulator of NaCl reabsorption in the distal nephron by mediating phosphorylation and activation of the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney downstream of WNK4 (PubMed:18270262). Mediates the inhibition of SLC4A4, SLC26A6 as well as CFTR activities (By similarity). Phosphorylates RELT (By similarity). {ECO:0000250|UniProtKB:Q9Z1W9, ECO:0000269|PubMed:12740379, ECO:0000269|PubMed:16669787, ECO:0000269|PubMed:18270262, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:34289367}. |
| Q9UGP4 | LIMD1 | S24 | ochoa | LIM domain-containing protein 1 | Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation. {ECO:0000269|PubMed:15542589, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22286099}. |
| Q9UH62 | ARMCX3 | S218 | ochoa | Armadillo repeat-containing X-linked protein 3 (ARM protein lost in epithelial cancers on chromosome X 3) (Protein ALEX3) | Regulates mitochondrial aggregation and transport in axons in living neurons. May link mitochondria to the TRAK2-kinesin motor complex via its interaction with Miro and TRAK2. Mitochondrial distribution and dynamics is regulated through ARMCX3 protein degradation, which is promoted by PCK and negatively regulated by WNT1. Enhances the SOX10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters. {ECO:0000250|UniProtKB:Q8BHS6}. |
| Q9UHC6 | CNTNAP2 | S1306 | ochoa | Contactin-associated protein-like 2 (Cell recognition molecule Caspr2) | Required for gap junction formation (Probable). Required, with CNTNAP1, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the juxtaparanodal region of the axo-glial junction. {ECO:0000250|UniProtKB:Q9CPW0, ECO:0000305|PubMed:33238150}. |
| Q9UKA4 | AKAP11 | S1523 | ochoa | A-kinase anchor protein 11 (AKAP-11) (A-kinase anchor protein 220 kDa) (AKAP 220) (hAKAP220) (Protein kinase A-anchoring protein 11) (PRKA11) | Binds to type II regulatory subunits of protein kinase A and anchors/targets them. |
| Q9UKJ3 | GPATCH8 | S491 | ochoa | G patch domain-containing protein 8 | None |
| Q9ULJ3 | ZBTB21 | S610 | ochoa | Zinc finger and BTB domain-containing protein 21 (Zinc finger protein 295) | Acts as a transcription repressor. {ECO:0000269|PubMed:15629158}. |
| Q9ULM0 | PLEKHH1 | S219 | ochoa | Pleckstrin homology domain-containing family H member 1 (PH domain-containing family H member 1) | None |
| Q9ULP9 | TBC1D24 | S28 | ochoa | TBC1 domain family member 24 | May act as a GTPase-activating protein for Rab family protein(s) (PubMed:20727515, PubMed:20797691). Involved in neuronal projections development, probably through a negative modulation of ARF6 function (PubMed:20727515). Involved in the regulation of synaptic vesicle trafficking (PubMed:31257402). {ECO:0000269|PubMed:20727515, ECO:0000269|PubMed:20797691, ECO:0000269|PubMed:31257402}. |
| Q9ULV3 | CIZ1 | S350 | ochoa | Cip1-interacting zinc finger protein (CDKN1A-interacting zinc finger protein 1) (Nuclear protein NP94) (Zinc finger protein 356) | May regulate the subcellular localization of CIP/WAF1. |
| Q9Y2H5 | PLEKHA6 | S314 | ochoa | Pleckstrin homology domain-containing family A member 6 (PH domain-containing family A member 6) (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3) | None |
| Q9Y2L9 | LRCH1 | S365 | ochoa | Leucine-rich repeat and calponin homology domain-containing protein 1 (Calponin homology domain-containing protein 1) (Neuronal protein 81) (NP81) | Acts as a negative regulator of GTPase CDC42 by sequestering CDC42-guanine exchange factor DOCK8. Probably by preventing CDC42 activation, negatively regulates CD4(+) T-cell migration. {ECO:0000269|PubMed:28028151}. |
| Q9Y2W1 | THRAP3 | S622 | ochoa | Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150) | Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). {ECO:0000269|PubMed:20123736, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:22424773, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:24043798}. |
| Q9Y2Z4 | YARS2 | S377 | ochoa | Tyrosine--tRNA ligase, mitochondrial (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) (TyrRS) | Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr). {ECO:0000269|PubMed:15779907, ECO:0000269|PubMed:17997975}. |
| Q9Y316 | MEMO1 | S86 | ochoa | Protein MEMO1 (C21orf19-like protein) (Hepatitis C virus NS5A-transactivated protein 7) (HCV NS5A-transactivated protein 7) (Mediator of ErbB2-driven cell motility 1) (Mediator of cell motility 1) (Memo-1) | May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell migration. {ECO:0000269|PubMed:15156151, ECO:0000269|PubMed:20937854}. |
| Q9Y5Z4 | HEBP2 | S181 | ochoa | Heme-binding protein 2 (Placental protein 23) (PP23) (Protein SOUL) | Can promote mitochondrial permeability transition and facilitate necrotic cell death under different types of stress conditions. {ECO:0000269|PubMed:17098234}. |
| Q9Y6M5 | SLC30A1 | S468 | ochoa | Proton-coupled zinc antiporter SLC30A1 (Solute carrier family 30 member 1) (Zinc transporter 1) | Zinc ion:proton antiporter that could function at the plasma membrane mediating zinc efflux from cells against its electrochemical gradient protecting them from intracellular zinc accumulation and toxicity (PubMed:31471319). Alternatively, could prevent the transport to the plasma membrane of CACNB2, the L-type calcium channels regulatory subunit, through a yet to be defined mechanism. By modulating the expression of these channels at the plasma membrane, could prevent calcium and zinc influx into cells. By the same mechanism, could also prevent L-type calcium channels-mediated heavy metal influx into cells (By similarity). In some cells, could also function as a zinc ion:proton antiporter mediating zinc entry into the lumen of cytoplasmic vesicles. In macrophages, can increase zinc ions concentration into the lumen of cytoplasmic vesicles containing engulfed bacteria and could help inactivate them (PubMed:32441444). Forms a complex with TMC6/EVER1 and TMC8/EVER2 at the ER membrane of keratynocytes which facilitates zinc uptake into the ER (PubMed:18158319). Down-regulates the activity of transcription factors induced by zinc and cytokines (PubMed:18158319). {ECO:0000250|UniProtKB:Q62720, ECO:0000269|PubMed:18158319, ECO:0000269|PubMed:31471319, ECO:0000269|PubMed:32441444}. |
| P06744 | GPI | S247 | Sugiyama | Glucose-6-phosphate isomerase (GPI) (EC 5.3.1.9) (Autocrine motility factor) (AMF) (Neuroleukin) (NLK) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI) (Sperm antigen 36) (SA-36) | In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis (PubMed:28803808). Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility (PubMed:11437381). Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons (PubMed:11004567, PubMed:3352745). It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion (PubMed:11004567, PubMed:3352745). {ECO:0000269|PubMed:11004567, ECO:0000269|PubMed:11437381, ECO:0000269|PubMed:28803808, ECO:0000269|PubMed:3352745}. |
| P35998 | PSMC2 | S89 | Sugiyama | 26S proteasome regulatory subunit 7 (26S proteasome AAA-ATPase subunit RPT1) (Proteasome 26S subunit ATPase 2) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000269|PubMed:1317798, ECO:0000269|PubMed:28539385, ECO:0000269|PubMed:9295362}. |
| Q3B891 | BRCA1 | S308 | GPS6 | BRCA1 DNA repair associated (BRCA1 protein) | None |
| Q9P032 | NDUFAF4 | S35 | Sugiyama | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 (Hormone-regulated proliferation-associated protein of 20 kDa) | Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) (PubMed:18179882, PubMed:28853723). May be involved in cell proliferation and survival of hormone-dependent tumor cells. May be a regulator of breast tumor cell invasion. {ECO:0000269|PubMed:14871833, ECO:0000269|PubMed:17001319, ECO:0000269|PubMed:18179882, ECO:0000269|PubMed:28853723}. |
| P13073 | COX4I1 | S74 | Sugiyama | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (Cytochrome c oxidase polypeptide IV) (Cytochrome c oxidase subunit IV isoform 1) (COX IV-1) | Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P00424}. |
| Q8IWW6 | ARHGAP12 | S215 | Sugiyama | Rho GTPase-activating protein 12 (Rho-type GTPase-activating protein 12) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| Q9Y490 | TLN1 | S1535 | Sugiyama | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| Q9Y4G6 | TLN2 | S1537 | Sugiyama | Talin-2 | As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity (By similarity). {ECO:0000250}. |
| Q9HBH7 | BEX1 | S102 | SIGNOR | Protein BEX1 (Brain-expressed X-linked protein 1) | Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states (By similarity). In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates (By similarity). {ECO:0000250|UniProtKB:Q3MKQ2, ECO:0000250|UniProtKB:Q9R224}. |
| P63165 | SUMO1 | S61 | Sugiyama | Small ubiquitin-related modifier 1 (SUMO-1) (GAP-modifying protein 1) (GMP1) (SMT3 homolog 3) (Sentrin) (Ubiquitin-homology domain protein PIC1) (Ubiquitin-like protein SMT3C) (Smt3C) (Ubiquitin-like protein UBL1) | Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1 (PubMed:19223394). Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3 (PubMed:24651376). {ECO:0000269|PubMed:18408734, ECO:0000269|PubMed:18538659, ECO:0000269|PubMed:19223394, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:24651376, ECO:0000269|PubMed:9019411, ECO:0000269|PubMed:9162015}. |
| Q16623 | STX1A | S188 | GPS6|SIGNOR|ELM|iPTMNet|EPSD | Syntaxin-1A (Neuron-specific antigen HPC-1) | Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis (PubMed:26635000). Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final fusion. Participates in the calcium-dependent regulation of acrosomal exocytosis in sperm (PubMed:23091057). Also plays an important role in the exocytosis of hormones such as insulin or glucagon-like peptide 1 (GLP-1) (By similarity). {ECO:0000250|UniProtKB:O35526, ECO:0000269|PubMed:23091057, ECO:0000269|PubMed:26635000}. |
| O00401 | WASL | S242 | EPSD | Actin nucleation-promoting factor WASL (Neural Wiskott-Aldrich syndrome protein) (N-WASP) | Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex (PubMed:16767080, PubMed:19366662, PubMed:19487689, PubMed:22847007, PubMed:22921828, PubMed:9422512). Involved in various processes, such as mitosis and cytokinesis, via its role in the regulation of actin polymerization (PubMed:19366662, PubMed:19487689, PubMed:22847007, PubMed:22921828, PubMed:9422512). Together with CDC42, involved in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia (PubMed:9422512). In addition to its role in the cytoplasm, also plays a role in the nucleus by regulating gene transcription, probably by promoting nuclear actin polymerization (PubMed:16767080). Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression (By similarity). Plays a role in dendrite spine morphogenesis (By similarity). Decreasing levels of DNMBP (using antisense RNA) alters apical junction morphology in cultured enterocytes, junctions curve instead of being nearly linear (PubMed:19767742). {ECO:0000250|UniProtKB:Q91YD9, ECO:0000269|PubMed:16767080, ECO:0000269|PubMed:19366662, ECO:0000269|PubMed:19487689, ECO:0000269|PubMed:19767742, ECO:0000269|PubMed:22847007, ECO:0000269|PubMed:22921828, ECO:0000269|PubMed:9422512}. |
| P42765 | ACAA2 | T87 | Sugiyama | 3-ketoacyl-CoA thiolase, mitochondrial (EC 2.3.1.16) (Acetyl-CoA acetyltransferase) (EC 2.3.1.9) (Acetyl-CoA acyltransferase) (Acyl-CoA hydrolase, mitochondrial) (EC 3.1.2.-, EC 3.1.2.1, EC 3.1.2.2) (Beta-ketothiolase) (Mitochondrial 3-oxoacyl-CoA thiolase) (T1) | In the production of energy from fats, this is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (Probable). Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain unbranched 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms (Probable). Also catalyzes the condensation of two acetyl-CoA molecules into acetoacetyl-CoA and could be involved in the production of ketone bodies (Probable). Also displays hydrolase activity on various fatty acyl-CoAs (PubMed:25478839). Thereby, could be responsible for the production of acetate in a side reaction to beta-oxidation (Probable). Abolishes BNIP3-mediated apoptosis and mitochondrial damage (PubMed:18371312). {ECO:0000269|PubMed:18371312, ECO:0000269|PubMed:25478839, ECO:0000305|PubMed:25478839}. |
| Q13188 | STK3 | S444 | Sugiyama | Serine/threonine-protein kinase 3 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 2) (MST-2) (STE20-like kinase MST2) (Serine/threonine-protein kinase Krs-1) [Cleaved into: Serine/threonine-protein kinase 3 36kDa subunit (MST2/N); Serine/threonine-protein kinase 3 20kDa subunit (MST2/C)] | Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation (PubMed:11278283, PubMed:8566796, PubMed:8816758). Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:15688006, PubMed:16930133, PubMed:23972470, PubMed:28087714, PubMed:29063833, PubMed:30622739). Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:15688006, PubMed:16930133, PubMed:23972470, PubMed:28087714). STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates NKX2-1 (By similarity). Phosphorylates NEK2 and plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosome, and its ability to phosphorylate CROCC and CEP250 (PubMed:21076410, PubMed:21723128). In conjunction with SAV1, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation (PubMed:21104395). Positively regulates RAF1 activation via suppression of the inhibitory phosphorylation of RAF1 on 'Ser-259' (PubMed:20212043). Phosphorylates MOBKL1A and RASSF2 (PubMed:19525978). Phosphorylates MOBKL1B on 'Thr-74'. Acts cooperatively with MOBKL1B to activate STK38 (PubMed:18328708, PubMed:18362890). {ECO:0000250|UniProtKB:Q9JI10, ECO:0000269|PubMed:11278283, ECO:0000269|PubMed:15688006, ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:18328708, ECO:0000269|PubMed:18362890, ECO:0000269|PubMed:19525978, ECO:0000269|PubMed:20212043, ECO:0000269|PubMed:21076410, ECO:0000269|PubMed:21104395, ECO:0000269|PubMed:21723128, ECO:0000269|PubMed:23972470, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:29063833, ECO:0000269|PubMed:30622739, ECO:0000269|PubMed:8566796, ECO:0000269|PubMed:8816758}. |
| P11441 | UBL4A | S128 | Sugiyama | Ubiquitin-like protein 4A (Ubiquitin-like protein GDX) | As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20676083, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20676083, PubMed:25535373, PubMed:28104892). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome (PubMed:28104892). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303). {ECO:0000269|PubMed:20676083, ECO:0000269|PubMed:21636303, ECO:0000269|PubMed:21743475, ECO:0000269|PubMed:25535373, ECO:0000269|PubMed:28104892}. |
| Q01082 | SPTBN1 | S35 | Sugiyama | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
| Q6VN20 | RANBP10 | S69 | Sugiyama | Ran-binding protein 10 (RanBP10) | May act as an adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation (PubMed:18222118). Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase. May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function (By similarity). {ECO:0000250|UniProtKB:Q6VN19, ECO:0000269|PubMed:18222118, ECO:0000269|PubMed:29911972, ECO:0000305}. |
| Q92499 | DDX1 | S541 | Sugiyama | ATP-dependent RNA helicase DDX1 (EC 3.6.4.13) (DEAD box protein 1) (DEAD box protein retinoblastoma) (DBP-RB) | Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 expression. Binds to the cyclin CCND2 promoter region. Associates with chromatin at the NF-kappa-B promoter region via association with RELA. Binds to poly(A) RNA. May be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB: together with archease (ZBTB8OS), acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation (PubMed:24870230). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1. Specifically binds (via helicase ATP-binding domain) on both short and long poly(I:C) dsRNA (By similarity). {ECO:0000250|UniProtKB:Q91VR5, ECO:0000269|PubMed:12183465, ECO:0000269|PubMed:15567440, ECO:0000269|PubMed:18335541, ECO:0000269|PubMed:18710941, ECO:0000269|PubMed:20573827, ECO:0000269|PubMed:24870230}.; FUNCTION: (Microbial infection) Required for HIV-1 Rev function as well as for HIV-1 and coronavirus IBV replication. Binds to the RRE sequence of HIV-1 mRNAs. {ECO:0000269|PubMed:15567440}.; FUNCTION: (Microbial infection) Required for Coronavirus IBV replication. {ECO:0000269|PubMed:20573827}. |
| P07305 | H1-0 | S66 | Sugiyama | Histone H1.0 (Histone H1') (Histone H1(0)) [Cleaved into: Histone H1.0, N-terminally processed] | Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The histones H1.0 are found in cells that are in terminal stages of differentiation or that have low rates of cell division. |
| P00966 | ASS1 | S131 | Sugiyama | Argininosuccinate synthase (EC 6.3.4.5) (Citrulline--aspartate ligase) | One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues. {ECO:0000305|PubMed:18473344, ECO:0000305|PubMed:27287393, ECO:0000305|PubMed:8792870}. |
| O95376 | ARIH2 | S113 | Sugiyama | E3 ubiquitin-protein ligase ARIH2 (ARI-2) (Protein ariadne-2 homolog) (EC 2.3.2.31) (Triad1 protein) | E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 (PubMed:16118314, PubMed:17646546, PubMed:19340006, PubMed:24076655, PubMed:33268465, PubMed:34518685, PubMed:38418882). Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-5-RING ubiquitin ligase complex (ECS complex, also named CRL5 complex) and initiating ubiquitination of ECS substrates: associates with ECS complex and specifically mediates addition of the first ubiquitin on ECS targets (PubMed:33268465, PubMed:34518685, PubMed:38418882). The initial ubiquitin is then elongated (PubMed:33268465). E3 ubiquitin-protein ligase activity is activated upon binding to neddylated form of the cullin-5 (CUL5) component of the ECS complex (PubMed:24076655). Together with the ECS(ASB9) complex, catalyzes ubiquitination of CKB (PubMed:33268465). Promotes ubiquitination of DCUN1D1 (PubMed:30587576). Mediates 'Lys-6', 'Lys-48'- and 'Lys-63'-linked polyubiquitination (PubMed:16118314, PubMed:17646546, PubMed:19340006). May play a role in myelopoiesis (PubMed:19340006). {ECO:0000269|PubMed:16118314, ECO:0000269|PubMed:17646546, ECO:0000269|PubMed:19340006, ECO:0000269|PubMed:24076655, ECO:0000269|PubMed:30587576, ECO:0000269|PubMed:33268465, ECO:0000269|PubMed:34518685, ECO:0000269|PubMed:38418882}.; FUNCTION: (Microbial infection) Following infection by HIV-1 virus, acts together with a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex) hijacked by the HIV-1 Vif protein, to catalyze ubiquitination and degradation of APOBEC3F and APOBEC3G. {ECO:0000269|PubMed:31253590, ECO:0000269|PubMed:36754086}. |
| Q9HBE1 | PATZ1 | S564 | Sugiyama | POZ-, AT hook-, and zinc finger-containing protein 1 (BTB/POZ domain zinc finger transcription factor) (Protein kinase A RI subunit alpha-associated protein) (Zinc finger and BTB domain-containing protein 19) (Zinc finger protein 278) (Zinc finger sarcoma gene protein) | Transcriptional regulator that plays a role in many biological processes such as embryogenesis, senescence, T-cell development or neurogenesis (PubMed:10713105, PubMed:25755280, PubMed:31875552). Interacts with the TP53 protein to control genes that are important in proliferation and in the DNA-damage response. Mechanistically, the interaction inhibits the DNA binding and transcriptional activity of TP53/p53 (PubMed:25755280). Part of the transcriptional network modulating regulatory T-cell development and controls the generation of the regulatory T-cell pool under homeostatic conditions (PubMed:31875552). {ECO:0000269|PubMed:10713105, ECO:0000269|PubMed:25755280, ECO:0000269|PubMed:31875552}.; FUNCTION: (Microbial infection) Plays a positive role in viral cDNA synthesis. {ECO:0000269|PubMed:31060775}. |
| Q96PY6 | NEK1 | S155 | Sugiyama | Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) (Renal carcinoma antigen NY-REN-55) | Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity (PubMed:20230784). Involved in DNA damage checkpoint control and for proper DNA damage repair (PubMed:20230784). In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death (PubMed:20230784). May be implicated in the control of meiosis (By similarity). Involved in cilium assembly (PubMed:21211617). {ECO:0000250|UniProtKB:P51954, ECO:0000269|PubMed:20230784, ECO:0000269|PubMed:21211617}. |
| P05556 | ITGB1 | S675 | Sugiyama | Integrin beta-1 (Fibronectin receptor subunit beta) (Glycoprotein IIa) (GPIIA) (VLA-4 subunit beta) (CD antigen CD29) | Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (By similarity). Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. When associated with alpha-7 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415, PubMed:24789099). ITGA4:ITGB1 and ITGA5:ITGB1 bind to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 acts as a receptor for fibronectin FN1 and mediates R-G-D-dependent cell adhesion to FN1 (PubMed:33962943). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430). ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (PubMed:31331973). Plays an important role in myoblast differentiation and fusion during skeletal myogenesis (By similarity). ITGA9:ITGB1 may play a crucial role in SVEP1/polydom-mediated myoblast cell adhesion (By similarity). Integrins ITGA9:ITGB1 and ITGA4:ITGB1 repress PRKCA-mediated L-type voltage-gated channel Ca(2+) influx and ROCK-mediated calcium sensitivity in vascular smooth muscle cells via their interaction with SVEP1, thereby inhibit vasocontraction (PubMed:35802072). {ECO:0000250|UniProtKB:P07228, ECO:0000250|UniProtKB:P09055, ECO:0000269|PubMed:10455171, ECO:0000269|PubMed:12473654, ECO:0000269|PubMed:12807887, ECO:0000269|PubMed:16256741, ECO:0000269|PubMed:17158881, ECO:0000269|PubMed:18635536, ECO:0000269|PubMed:18804435, ECO:0000269|PubMed:19064666, ECO:0000269|PubMed:21768292, ECO:0000269|PubMed:23125415, ECO:0000269|PubMed:24789099, ECO:0000269|PubMed:25398877, ECO:0000269|PubMed:29030430, ECO:0000269|PubMed:31331973, ECO:0000269|PubMed:33962943, ECO:0000269|PubMed:35802072, ECO:0000269|PubMed:7523423}.; FUNCTION: [Isoform 2]: Interferes with isoform 1 resulting in a dominant negative effect on cell adhesion and migration (in vitro). {ECO:0000305|PubMed:2249781}.; FUNCTION: [Isoform 5]: Isoform 5 displaces isoform 1 in striated muscles. {ECO:0000250|UniProtKB:P09055}.; FUNCTION: (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human echoviruses 1 and 8. {ECO:0000269|PubMed:8411387}.; FUNCTION: (Microbial infection) Acts as a receptor for Cytomegalovirus/HHV-5. {ECO:0000269|PubMed:20660204}.; FUNCTION: (Microbial infection) Acts as a receptor for Epstein-Barr virus/HHV-4. {ECO:0000269|PubMed:17945327}.; FUNCTION: (Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for Human parvovirus B19. {ECO:0000269|PubMed:12907437}.; FUNCTION: (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human rotavirus. {ECO:0000269|PubMed:12941907}.; FUNCTION: (Microbial infection) Acts as a receptor for Mammalian reovirus. {ECO:0000269|PubMed:16501085}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, integrin ITGA5:ITGB1 binding to extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. {ECO:0000269|PubMed:10397733}.; FUNCTION: (Microbial infection) Interacts with CotH proteins expressed by fungi of the order mucorales, the causative agent of mucormycosis, which plays an important role in epithelial cell invasion by the fungi (PubMed:32487760). Integrin ITGA3:ITGB1 may act as a receptor for R.delemar CotH7 in alveolar epithelial cells, which may be an early step in pulmonary mucormycosis disease progression (PubMed:32487760). {ECO:0000269|PubMed:32487760}.; FUNCTION: (Microbial infection) May serve as a receptor for adhesin A (nadA) of N.meningitidis. {ECO:0000305|PubMed:21471204}.; FUNCTION: (Microbial infection) Facilitates rabies infection in a fibronectin-dependent manner and participates in rabies virus traffic after internalization. {ECO:0000269|PubMed:31666383}. |
| P0DPB6 | POLR1D | S78 | Sugiyama | DNA-directed RNA polymerases I and III subunit RPAC2 (RNA polymerases I and III subunit AC2) (AC19) (DNA-directed RNA polymerase I subunit D) (RNA polymerase I 16 kDa subunit) (RPA16) (RPC16) (hRPA19) | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and short non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs, respectively. {ECO:0000250|UniProtKB:P28000, ECO:0000269|PubMed:20413673, ECO:0000269|PubMed:34671025, ECO:0000269|PubMed:34887565, ECO:0000269|PubMed:35637192, ECO:0000269|PubMed:36271492}. |
| Q9NYF8 | BCLAF1 | S345 | Sugiyama | Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) | Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9818035 | NFE2L2 regulating ER-stress associated genes | 0.000117 | 3.932 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 0.000518 | 3.285 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 0.000682 | 3.166 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 0.000682 | 3.166 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 0.000118 | 3.928 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.000222 | 3.653 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.000455 | 3.342 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.000455 | 3.342 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.000508 | 3.295 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.000691 | 3.161 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.000341 | 3.468 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.000364 | 3.439 |
| R-HSA-1640170 | Cell Cycle | 0.000365 | 3.438 |
| R-HSA-75153 | Apoptotic execution phase | 0.000203 | 3.693 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.000323 | 3.491 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.000960 | 3.018 |
| R-HSA-373760 | L1CAM interactions | 0.000958 | 3.019 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.001200 | 2.921 |
| R-HSA-9675135 | Diseases of DNA repair | 0.001540 | 2.813 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.001745 | 2.758 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.002386 | 2.622 |
| R-HSA-435354 | Zinc transporters | 0.002764 | 2.558 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.003173 | 2.499 |
| R-HSA-983189 | Kinesins | 0.004112 | 2.386 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.003923 | 2.406 |
| R-HSA-69275 | G2/M Transition | 0.004566 | 2.341 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.004856 | 2.314 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.006130 | 2.213 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.006852 | 2.164 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.006852 | 2.164 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.006852 | 2.164 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.006852 | 2.164 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.006166 | 2.210 |
| R-HSA-68877 | Mitotic Prometaphase | 0.005644 | 2.248 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.006340 | 2.198 |
| R-HSA-73894 | DNA Repair | 0.005976 | 2.224 |
| R-HSA-447038 | NrCAM interactions | 0.005266 | 2.279 |
| R-HSA-422475 | Axon guidance | 0.006452 | 2.190 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.006621 | 2.179 |
| R-HSA-109581 | Apoptosis | 0.006826 | 2.166 |
| R-HSA-9909396 | Circadian clock | 0.008079 | 2.093 |
| R-HSA-5357801 | Programmed Cell Death | 0.008159 | 2.088 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 0.008533 | 2.069 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.008852 | 2.053 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.009065 | 2.043 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.010217 | 1.991 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.011055 | 1.956 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.011287 | 1.947 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.010703 | 1.971 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.012227 | 1.913 |
| R-HSA-6806834 | Signaling by MET | 0.011721 | 1.931 |
| R-HSA-9675108 | Nervous system development | 0.011576 | 1.936 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.012254 | 1.912 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 0.012496 | 1.903 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 0.015100 | 1.821 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.015165 | 1.819 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.015165 | 1.819 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.013370 | 1.874 |
| R-HSA-442380 | Zinc influx into cells by the SLC39 gene family | 0.014724 | 1.832 |
| R-HSA-199991 | Membrane Trafficking | 0.014686 | 1.833 |
| R-HSA-9828806 | Maturation of hRSV A proteins | 0.014429 | 1.841 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.015798 | 1.801 |
| R-HSA-451308 | Activation of Ca-permeable Kainate Receptor | 0.017110 | 1.767 |
| R-HSA-5689877 | Josephin domain DUBs | 0.017110 | 1.767 |
| R-HSA-5693538 | Homology Directed Repair | 0.016418 | 1.785 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.018109 | 1.742 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.019937 | 1.700 |
| R-HSA-451306 | Ionotropic activity of kainate receptors | 0.019648 | 1.707 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 0.019648 | 1.707 |
| R-HSA-8979227 | Triglyceride metabolism | 0.019937 | 1.700 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.022299 | 1.652 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.022456 | 1.649 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.021086 | 1.676 |
| R-HSA-68886 | M Phase | 0.021696 | 1.664 |
| R-HSA-69481 | G2/M Checkpoints | 0.022509 | 1.648 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.023797 | 1.623 |
| R-HSA-5673000 | RAF activation | 0.025348 | 1.596 |
| R-HSA-877312 | Regulation of IFNG signaling | 0.025161 | 1.599 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.024111 | 1.618 |
| R-HSA-8851805 | MET activates RAS signaling | 0.025161 | 1.599 |
| R-HSA-373755 | Semaphorin interactions | 0.024005 | 1.620 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.026812 | 1.572 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.028410 | 1.547 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.028541 | 1.545 |
| R-HSA-1475029 | Reversible hydration of carbon dioxide | 0.028126 | 1.551 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 0.028126 | 1.551 |
| R-HSA-68882 | Mitotic Anaphase | 0.029339 | 1.533 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.029970 | 1.523 |
| R-HSA-163560 | Triglyceride catabolism | 0.028610 | 1.543 |
| R-HSA-9709275 | Impaired BRCA2 translocation to the nucleus | 0.029973 | 1.523 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 0.029973 | 1.523 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 0.029973 | 1.523 |
| R-HSA-9763198 | Impaired BRCA2 binding to SEM1 (DSS1) | 0.029973 | 1.523 |
| R-HSA-1296072 | Voltage gated Potassium channels | 0.030321 | 1.518 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 0.031224 | 1.506 |
| R-HSA-416700 | Other semaphorin interactions | 0.034449 | 1.463 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.034449 | 1.463 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.033899 | 1.470 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 0.033899 | 1.470 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.038825 | 1.411 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.041265 | 1.384 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 0.041265 | 1.384 |
| R-HSA-3560792 | Defective SLC26A2 causes chondrodysplasias | 0.044622 | 1.350 |
| R-HSA-2028269 | Signaling by Hippo | 0.044848 | 1.348 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.046035 | 1.337 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.048540 | 1.314 |
| R-HSA-425410 | Metal ion SLC transporters | 0.054880 | 1.261 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 0.048540 | 1.314 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.054899 | 1.260 |
| R-HSA-1299503 | TWIK related potassium channel (TREK) | 0.059050 | 1.229 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.064334 | 1.192 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.064334 | 1.192 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.056874 | 1.245 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 0.056241 | 1.250 |
| R-HSA-446343 | Localization of the PINCH-ILK-PARVIN complex to focal adhesions | 0.059050 | 1.229 |
| R-HSA-912446 | Meiotic recombination | 0.062139 | 1.207 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.056241 | 1.250 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.064334 | 1.192 |
| R-HSA-373753 | Nephrin family interactions | 0.056241 | 1.250 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.064334 | 1.192 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.056362 | 1.249 |
| R-HSA-75157 | FasL/ CD95L signaling | 0.073262 | 1.135 |
| R-HSA-9673766 | Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | 0.073262 | 1.135 |
| R-HSA-9818025 | NFE2L2 regulating TCA cycle genes | 0.101047 | 0.995 |
| R-HSA-9818026 | NFE2L2 regulating inflammation associated genes | 0.101047 | 0.995 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.114627 | 0.941 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 0.141177 | 0.850 |
| R-HSA-9010642 | ROBO receptors bind AKAP5 | 0.154153 | 0.812 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 0.166934 | 0.777 |
| R-HSA-5218900 | CASP8 activity is inhibited | 0.166934 | 0.777 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 0.179523 | 0.746 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 0.179523 | 0.746 |
| R-HSA-6803529 | FGFR2 alternative splicing | 0.068519 | 1.164 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 0.068519 | 1.164 |
| R-HSA-4839744 | Signaling by APC mutants | 0.191922 | 0.717 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.191922 | 0.717 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.191922 | 0.717 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.191922 | 0.717 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 0.204134 | 0.690 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.204134 | 0.690 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.204134 | 0.690 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.216163 | 0.665 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.216163 | 0.665 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.216163 | 0.665 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.216163 | 0.665 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.216163 | 0.665 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.090680 | 1.042 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.090680 | 1.042 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.095336 | 1.021 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.095336 | 1.021 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.100059 | 1.000 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.251173 | 0.600 |
| R-HSA-73780 | RNA Polymerase III Chain Elongation | 0.251173 | 0.600 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 0.251173 | 0.600 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.262493 | 0.581 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.273643 | 0.563 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.145099 | 0.838 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.145099 | 0.838 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.284625 | 0.546 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.155610 | 0.808 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 0.295442 | 0.530 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.160919 | 0.793 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.160919 | 0.793 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.306096 | 0.514 |
| R-HSA-774815 | Nucleosome assembly | 0.193385 | 0.714 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.193385 | 0.714 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.198879 | 0.701 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.198879 | 0.701 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.198879 | 0.701 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 0.357006 | 0.447 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 0.357006 | 0.447 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.232171 | 0.634 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.232171 | 0.634 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 0.366733 | 0.436 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.237759 | 0.624 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.237759 | 0.624 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.184711 | 0.734 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.293791 | 0.532 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.293791 | 0.532 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.304964 | 0.516 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.310539 | 0.508 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.349253 | 0.457 |
| R-HSA-380287 | Centrosome maturation | 0.360187 | 0.443 |
| R-HSA-167172 | Transcription of the HIV genome | 0.321660 | 0.493 |
| R-HSA-167169 | HIV Transcription Elongation | 0.160919 | 0.793 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.124574 | 0.905 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 0.228010 | 0.642 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.160919 | 0.793 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.171633 | 0.765 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.171633 | 0.765 |
| R-HSA-166665 | Terminal pathway of complement | 0.114627 | 0.941 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.155610 | 0.808 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.193385 | 0.714 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.198879 | 0.701 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.090680 | 1.042 |
| R-HSA-381042 | PERK regulates gene expression | 0.134747 | 0.870 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.259768 | 0.585 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.259768 | 0.585 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.354728 | 0.450 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.263841 | 0.579 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 0.072791 | 1.138 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.166260 | 0.779 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.177033 | 0.752 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.227884 | 0.642 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.343762 | 0.464 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.385748 | 0.414 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.332737 | 0.478 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.160919 | 0.793 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.316589 | 0.500 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.376460 | 0.424 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.075353 | 1.123 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.171633 | 0.765 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.092623 | 1.033 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.232171 | 0.634 |
| R-HSA-8875513 | MET interacts with TNS proteins | 0.073262 | 1.135 |
| R-HSA-8866376 | Reelin signalling pathway | 0.101047 | 0.995 |
| R-HSA-203641 | NOSTRIN mediated eNOS trafficking | 0.141177 | 0.850 |
| R-HSA-8866904 | Negative regulation of activity of TFAP2 (AP-2) family transcription factors | 0.154153 | 0.812 |
| R-HSA-3371378 | Regulation by c-FLIP | 0.154153 | 0.812 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.204134 | 0.690 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.204134 | 0.690 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.204134 | 0.690 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.228010 | 0.642 |
| R-HSA-5576886 | Phase 4 - resting membrane potential | 0.262493 | 0.581 |
| R-HSA-1566977 | Fibronectin matrix formation | 0.273643 | 0.563 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.295442 | 0.530 |
| R-HSA-8851708 | Signaling by FGFR2 IIIa TM | 0.306096 | 0.514 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.177033 | 0.752 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.082067 | 1.086 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 0.337104 | 0.472 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 0.347131 | 0.460 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.347131 | 0.460 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 0.357006 | 0.447 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.226592 | 0.645 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.366733 | 0.436 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.282595 | 0.549 |
| R-HSA-6799198 | Complex I biogenesis | 0.293791 | 0.532 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.327205 | 0.485 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.365630 | 0.437 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.169714 | 0.770 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.295442 | 0.530 |
| R-HSA-170968 | Frs2-mediated activation | 0.228010 | 0.642 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.231106 | 0.636 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 0.262493 | 0.581 |
| R-HSA-9707616 | Heme signaling | 0.288195 | 0.540 |
| R-HSA-1500620 | Meiosis | 0.169714 | 0.770 |
| R-HSA-9620244 | Long-term potentiation | 0.081582 | 1.088 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.338256 | 0.471 |
| R-HSA-162587 | HIV Life Cycle | 0.277260 | 0.557 |
| R-HSA-169893 | Prolonged ERK activation events | 0.262493 | 0.581 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.166022 | 0.780 |
| R-HSA-182971 | EGFR downregulation | 0.109693 | 0.960 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 0.154153 | 0.812 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.068519 | 1.164 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 0.204134 | 0.690 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 0.347131 | 0.460 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.343762 | 0.464 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.260166 | 0.585 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 0.306096 | 0.514 |
| R-HSA-5689603 | UCH proteinases | 0.137426 | 0.862 |
| R-HSA-8951664 | Neddylation | 0.305873 | 0.514 |
| R-HSA-162906 | HIV Infection | 0.323634 | 0.490 |
| R-HSA-429593 | Inositol transporters | 0.101047 | 0.995 |
| R-HSA-187706 | Signalling to p38 via RIT and RIN | 0.114627 | 0.941 |
| R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 0.114627 | 0.941 |
| R-HSA-69416 | Dimerization of procaspase-8 | 0.154153 | 0.812 |
| R-HSA-170984 | ARMS-mediated activation | 0.166934 | 0.777 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.204134 | 0.690 |
| R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 0.095336 | 1.021 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 0.326925 | 0.486 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.366733 | 0.436 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 0.366733 | 0.436 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.169714 | 0.770 |
| R-HSA-3000157 | Laminin interactions | 0.376312 | 0.424 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.376312 | 0.424 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.171633 | 0.765 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.288195 | 0.540 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.304964 | 0.516 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.119560 | 0.922 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.166260 | 0.779 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.110758 | 0.956 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.288195 | 0.540 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.247602 | 0.606 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 0.198879 | 0.701 |
| R-HSA-9707587 | Regulation of HMOX1 expression and activity | 0.087260 | 1.059 |
| R-HSA-5576890 | Phase 3 - rapid repolarisation | 0.141177 | 0.850 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 0.216163 | 0.665 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.109693 | 0.960 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 0.251173 | 0.600 |
| R-HSA-9857492 | Protein lipoylation | 0.251173 | 0.600 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 0.251173 | 0.600 |
| R-HSA-1237044 | Erythrocytes take up carbon dioxide and release oxygen | 0.306096 | 0.514 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 0.385748 | 0.414 |
| R-HSA-379724 | tRNA Aminoacylation | 0.276990 | 0.558 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 0.385748 | 0.414 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.187911 | 0.726 |
| R-HSA-9659379 | Sensory processing of sound | 0.147943 | 0.830 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.119560 | 0.922 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 0.316589 | 0.500 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.310539 | 0.508 |
| R-HSA-112316 | Neuronal System | 0.214013 | 0.670 |
| R-HSA-1480926 | O2/CO2 exchange in erythrocytes | 0.306096 | 0.514 |
| R-HSA-397014 | Muscle contraction | 0.279536 | 0.554 |
| R-HSA-5250971 | Toxicity of botulinum toxin type C (botC) | 0.101047 | 0.995 |
| R-HSA-447041 | CHL1 interactions | 0.141177 | 0.850 |
| R-HSA-5682910 | LGI-ADAM interactions | 0.191922 | 0.717 |
| R-HSA-427601 | Inorganic anion exchange by SLC26 transporters | 0.191922 | 0.717 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.216163 | 0.665 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.216163 | 0.665 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.216163 | 0.665 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 0.228010 | 0.642 |
| R-HSA-174362 | Transport and metabolism of PAPS | 0.251173 | 0.600 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 0.316589 | 0.500 |
| R-HSA-8874081 | MET activates PTK2 signaling | 0.385748 | 0.414 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.271383 | 0.566 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.173429 | 0.761 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.114599 | 0.941 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 0.251173 | 0.600 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.162355 | 0.790 |
| R-HSA-177929 | Signaling by EGFR | 0.254559 | 0.594 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.180928 | 0.742 |
| R-HSA-68875 | Mitotic Prophase | 0.333853 | 0.476 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.282595 | 0.549 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 0.179523 | 0.746 |
| R-HSA-1296346 | Tandem pore domain potassium channels | 0.179523 | 0.746 |
| R-HSA-1247673 | Erythrocytes take up oxygen and release carbon dioxide | 0.216163 | 0.665 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 0.251173 | 0.600 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.273643 | 0.563 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.385748 | 0.414 |
| R-HSA-1474165 | Reproduction | 0.383267 | 0.416 |
| R-HSA-73886 | Chromosome Maintenance | 0.152003 | 0.818 |
| R-HSA-5688426 | Deubiquitination | 0.128931 | 0.890 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.337104 | 0.472 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.354728 | 0.450 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.244106 | 0.612 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.165709 | 0.781 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.083925 | 1.076 |
| R-HSA-435368 | Zinc efflux and compartmentalization by the SLC30 family | 0.101047 | 0.995 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.119560 | 0.922 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.119560 | 0.922 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 0.284625 | 0.546 |
| R-HSA-9931295 | PD-L1(CD274) glycosylation and translocation to plasma membrane | 0.326925 | 0.486 |
| R-HSA-9830674 | Formation of the ureteric bud | 0.357006 | 0.447 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.140893 | 0.851 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.338256 | 0.471 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.331586 | 0.479 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.150336 | 0.823 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.077147 | 1.113 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.077147 | 1.113 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.151506 | 0.820 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.196546 | 0.707 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.090680 | 1.042 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.228010 | 0.642 |
| R-HSA-75892 | Platelet Adhesion to exposed collagen | 0.228010 | 0.642 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.262493 | 0.581 |
| R-HSA-203927 | MicroRNA (miRNA) biogenesis | 0.376312 | 0.424 |
| R-HSA-70635 | Urea cycle | 0.385748 | 0.414 |
| R-HSA-3214842 | HDMs demethylate histones | 0.081582 | 1.088 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.343762 | 0.464 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 0.166934 | 0.777 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.086094 | 1.065 |
| R-HSA-9683610 | Maturation of nucleoprotein | 0.228010 | 0.642 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.119560 | 0.922 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.253962 | 0.595 |
| R-HSA-1266738 | Developmental Biology | 0.302501 | 0.519 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.184711 | 0.734 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.343762 | 0.464 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.119602 | 0.922 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.215114 | 0.667 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.154153 | 0.812 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.166934 | 0.777 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.080690 | 1.093 |
| R-HSA-210991 | Basigin interactions | 0.326925 | 0.486 |
| R-HSA-1296071 | Potassium Channels | 0.082067 | 1.086 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.385748 | 0.414 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.254559 | 0.594 |
| R-HSA-162582 | Signal Transduction | 0.094850 | 1.023 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.077907 | 1.108 |
| R-HSA-445144 | Signal transduction by L1 | 0.316589 | 0.500 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.187911 | 0.726 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 0.337104 | 0.472 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.366733 | 0.436 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 0.385748 | 0.414 |
| R-HSA-114608 | Platelet degranulation | 0.172207 | 0.764 |
| R-HSA-5576891 | Cardiac conduction | 0.387356 | 0.412 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.251173 | 0.600 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.337104 | 0.472 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.387214 | 0.412 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 0.376312 | 0.424 |
| R-HSA-5218859 | Regulated Necrosis | 0.321660 | 0.493 |
| R-HSA-9833482 | PKR-mediated signaling | 0.151506 | 0.820 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.230689 | 0.637 |
| R-HSA-9694631 | Maturation of nucleoprotein | 0.306096 | 0.514 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.193283 | 0.714 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.123915 | 0.907 |
| R-HSA-8983711 | OAS antiviral response | 0.216163 | 0.665 |
| R-HSA-3000170 | Syndecan interactions | 0.357006 | 0.447 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 0.376312 | 0.424 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.276106 | 0.559 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.288195 | 0.540 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.106729 | 0.972 |
| R-HSA-449836 | Other interleukin signaling | 0.306096 | 0.514 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.344496 | 0.463 |
| R-HSA-1483255 | PI Metabolism | 0.247602 | 0.606 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 0.273643 | 0.563 |
| R-HSA-163685 | Integration of energy metabolism | 0.205673 | 0.687 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.338256 | 0.471 |
| R-HSA-1500931 | Cell-Cell communication | 0.252973 | 0.597 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.293791 | 0.532 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.371054 | 0.431 |
| R-HSA-190236 | Signaling by FGFR | 0.231529 | 0.635 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.146956 | 0.833 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.070140 | 1.154 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.381847 | 0.418 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.253962 | 0.595 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.295442 | 0.530 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.137237 | 0.863 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.360187 | 0.443 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.347131 | 0.460 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.304964 | 0.516 |
| R-HSA-168799 | Neurotoxicity of clostridium toxins | 0.347131 | 0.460 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.119614 | 0.922 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.365630 | 0.437 |
| R-HSA-4839726 | Chromatin organization | 0.389419 | 0.410 |
| R-HSA-983712 | Ion channel transport | 0.389834 | 0.409 |
| R-HSA-9609646 | HCMV Infection | 0.392413 | 0.406 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.392561 | 0.406 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.395042 | 0.403 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.395042 | 0.403 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.395042 | 0.403 |
| R-HSA-75109 | Triglyceride biosynthesis | 0.395042 | 0.403 |
| R-HSA-1483213 | Synthesis of PE | 0.395042 | 0.403 |
| R-HSA-264876 | Insulin processing | 0.395042 | 0.403 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.397886 | 0.400 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.403190 | 0.394 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 0.404195 | 0.393 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.404195 | 0.393 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.404195 | 0.393 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 0.404195 | 0.393 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 0.404195 | 0.393 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.404195 | 0.393 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.408472 | 0.389 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.411739 | 0.385 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.413210 | 0.384 |
| R-HSA-72086 | mRNA Capping | 0.413210 | 0.384 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.413210 | 0.384 |
| R-HSA-180024 | DARPP-32 events | 0.413210 | 0.384 |
| R-HSA-9609690 | HCMV Early Events | 0.413678 | 0.383 |
| R-HSA-2262752 | Cellular responses to stress | 0.414305 | 0.383 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.415776 | 0.381 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.418968 | 0.378 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.422090 | 0.375 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.422090 | 0.375 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.422090 | 0.375 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 0.422090 | 0.375 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.422742 | 0.374 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.424180 | 0.372 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.427217 | 0.369 |
| R-HSA-70268 | Pyruvate metabolism | 0.429368 | 0.367 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.429368 | 0.367 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.430836 | 0.366 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.430836 | 0.366 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 0.430836 | 0.366 |
| R-HSA-162588 | Budding and maturation of HIV virion | 0.430836 | 0.366 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.430836 | 0.366 |
| R-HSA-2129379 | Molecules associated with elastic fibres | 0.430836 | 0.366 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.433957 | 0.363 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.439450 | 0.357 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 0.439450 | 0.357 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.444783 | 0.352 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.444783 | 0.352 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.447934 | 0.349 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.447934 | 0.349 |
| R-HSA-354192 | Integrin signaling | 0.447934 | 0.349 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.447934 | 0.349 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.449869 | 0.347 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.454930 | 0.342 |
| R-HSA-390522 | Striated Muscle Contraction | 0.456290 | 0.341 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.456290 | 0.341 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.456290 | 0.341 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.456290 | 0.341 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 0.456290 | 0.341 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.456290 | 0.341 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 0.456290 | 0.341 |
| R-HSA-391251 | Protein folding | 0.459964 | 0.337 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.459964 | 0.337 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.459964 | 0.337 |
| R-HSA-69242 | S Phase | 0.463435 | 0.334 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.464520 | 0.333 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 0.464520 | 0.333 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.464520 | 0.333 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 0.464520 | 0.333 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.464520 | 0.333 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.464520 | 0.333 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 0.464520 | 0.333 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.469950 | 0.328 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.470604 | 0.327 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.470744 | 0.327 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.472626 | 0.325 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.472626 | 0.325 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.472626 | 0.325 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.472626 | 0.325 |
| R-HSA-187687 | Signalling to ERKs | 0.472626 | 0.325 |
| R-HSA-169911 | Regulation of Apoptosis | 0.472626 | 0.325 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.472626 | 0.325 |
| R-HSA-77289 | Mitochondrial Fatty Acid Beta-Oxidation | 0.474902 | 0.323 |
| R-HSA-446728 | Cell junction organization | 0.475268 | 0.323 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.480610 | 0.318 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 0.480610 | 0.318 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.480610 | 0.318 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.480610 | 0.318 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 0.480610 | 0.318 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.480610 | 0.318 |
| R-HSA-1839126 | FGFR2 mutant receptor activation | 0.480610 | 0.318 |
| R-HSA-8853659 | RET signaling | 0.480610 | 0.318 |
| R-HSA-9824446 | Viral Infection Pathways | 0.482419 | 0.317 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.484722 | 0.315 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.484722 | 0.315 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.488474 | 0.311 |
| R-HSA-4641258 | Degradation of DVL | 0.488474 | 0.311 |
| R-HSA-4641257 | Degradation of AXIN | 0.488474 | 0.311 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.488474 | 0.311 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.488474 | 0.311 |
| R-HSA-157579 | Telomere Maintenance | 0.489589 | 0.310 |
| R-HSA-422356 | Regulation of insulin secretion | 0.494427 | 0.306 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.496219 | 0.304 |
| R-HSA-1566948 | Elastic fibre formation | 0.496219 | 0.304 |
| R-HSA-8875878 | MET promotes cell motility | 0.496219 | 0.304 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 0.496219 | 0.304 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.496219 | 0.304 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.499236 | 0.302 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.503847 | 0.298 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.503847 | 0.298 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.503847 | 0.298 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.503847 | 0.298 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 0.503847 | 0.298 |
| R-HSA-69541 | Stabilization of p53 | 0.503847 | 0.298 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.504016 | 0.298 |
| R-HSA-70171 | Glycolysis | 0.504016 | 0.298 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.509513 | 0.293 |
| R-HSA-9646399 | Aggrephagy | 0.511360 | 0.291 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.511360 | 0.291 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.511360 | 0.291 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.511360 | 0.291 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.511360 | 0.291 |
| R-HSA-9854311 | Maturation of TCA enzymes and regulation of TCA cycle | 0.511360 | 0.291 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.511360 | 0.291 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.511360 | 0.291 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.511360 | 0.291 |
| R-HSA-202433 | Generation of second messenger molecules | 0.511360 | 0.291 |
| R-HSA-379726 | Mitochondrial tRNA aminoacylation | 0.511360 | 0.291 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.513488 | 0.289 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.513488 | 0.289 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.518760 | 0.285 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 0.518760 | 0.285 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.518760 | 0.285 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.518760 | 0.285 |
| R-HSA-9694548 | Maturation of spike protein | 0.518760 | 0.285 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.518760 | 0.285 |
| R-HSA-449147 | Signaling by Interleukins | 0.522612 | 0.282 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.522840 | 0.282 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.522840 | 0.282 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.522840 | 0.282 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.526048 | 0.279 |
| R-HSA-167161 | HIV Transcription Initiation | 0.526048 | 0.279 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.526048 | 0.279 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.526048 | 0.279 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.526048 | 0.279 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.526048 | 0.279 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.526048 | 0.279 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.526048 | 0.279 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.526048 | 0.279 |
| R-HSA-9683701 | Translation of Structural Proteins | 0.526048 | 0.279 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.533227 | 0.273 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 0.533227 | 0.273 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.540297 | 0.267 |
| R-HSA-9710421 | Defective pyroptosis | 0.540297 | 0.267 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.540297 | 0.267 |
| R-HSA-8854214 | TBC/RABGAPs | 0.540297 | 0.267 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.540297 | 0.267 |
| R-HSA-211000 | Gene Silencing by RNA | 0.541180 | 0.267 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.545688 | 0.263 |
| R-HSA-9907900 | Proteasome assembly | 0.547260 | 0.262 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.547260 | 0.262 |
| R-HSA-373752 | Netrin-1 signaling | 0.547260 | 0.262 |
| R-HSA-72306 | tRNA processing | 0.549564 | 0.260 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.554118 | 0.256 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.554118 | 0.256 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.554118 | 0.256 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.554118 | 0.256 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.554118 | 0.256 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.554118 | 0.256 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.554118 | 0.256 |
| R-HSA-9824272 | Somitogenesis | 0.554118 | 0.256 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.554118 | 0.256 |
| R-HSA-3560782 | Diseases associated with glycosaminoglycan metabolism | 0.554118 | 0.256 |
| R-HSA-202403 | TCR signaling | 0.554612 | 0.256 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.560195 | 0.252 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.560195 | 0.252 |
| R-HSA-1280218 | Adaptive Immune System | 0.560441 | 0.251 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.560873 | 0.251 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.560873 | 0.251 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.560873 | 0.251 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.560873 | 0.251 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.560873 | 0.251 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.567526 | 0.246 |
| R-HSA-1483191 | Synthesis of PC | 0.567526 | 0.246 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.572088 | 0.243 |
| R-HSA-9634597 | GPER1 signaling | 0.574078 | 0.241 |
| R-HSA-70263 | Gluconeogenesis | 0.574078 | 0.241 |
| R-HSA-611105 | Respiratory electron transport | 0.577574 | 0.238 |
| R-HSA-913531 | Interferon Signaling | 0.579867 | 0.237 |
| R-HSA-9766229 | Degradation of CDH1 | 0.580532 | 0.236 |
| R-HSA-73893 | DNA Damage Bypass | 0.580532 | 0.236 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.580532 | 0.236 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.580532 | 0.236 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.580532 | 0.236 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.580637 | 0.236 |
| R-HSA-2559583 | Cellular Senescence | 0.584405 | 0.233 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.586888 | 0.231 |
| R-HSA-109704 | PI3K Cascade | 0.586888 | 0.231 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.586888 | 0.231 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.591431 | 0.228 |
| R-HSA-6798695 | Neutrophil degranulation | 0.592803 | 0.227 |
| R-HSA-9864848 | Complex IV assembly | 0.593149 | 0.227 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.593149 | 0.227 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.593149 | 0.227 |
| R-HSA-70326 | Glucose metabolism | 0.593227 | 0.227 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.593227 | 0.227 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.599188 | 0.222 |
| R-HSA-72187 | mRNA 3'-end processing | 0.599314 | 0.222 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.599314 | 0.222 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.599314 | 0.222 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.599314 | 0.222 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.599314 | 0.222 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.599314 | 0.222 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.601462 | 0.221 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.602676 | 0.220 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.605387 | 0.218 |
| R-HSA-1221632 | Meiotic synapsis | 0.605387 | 0.218 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.605387 | 0.218 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.605387 | 0.218 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.605387 | 0.218 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.605387 | 0.218 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.606373 | 0.217 |
| R-HSA-3371556 | Cellular response to heat stress | 0.609572 | 0.215 |
| R-HSA-212436 | Generic Transcription Pathway | 0.610906 | 0.214 |
| R-HSA-72649 | Translation initiation complex formation | 0.611368 | 0.214 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.611368 | 0.214 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.612922 | 0.213 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.617259 | 0.210 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.617259 | 0.210 |
| R-HSA-5617833 | Cilium Assembly | 0.617494 | 0.209 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.617556 | 0.209 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.621501 | 0.207 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.623061 | 0.205 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.623061 | 0.205 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.623061 | 0.205 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.623061 | 0.205 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.623061 | 0.205 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.625953 | 0.203 |
| R-HSA-112399 | IRS-mediated signalling | 0.628775 | 0.202 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.628775 | 0.202 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.634403 | 0.198 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.634403 | 0.198 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.634403 | 0.198 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.636478 | 0.196 |
| R-HSA-191859 | snRNP Assembly | 0.639946 | 0.194 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.639946 | 0.194 |
| R-HSA-180786 | Extension of Telomeres | 0.639946 | 0.194 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 0.639946 | 0.194 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.645406 | 0.190 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.645406 | 0.190 |
| R-HSA-351202 | Metabolism of polyamines | 0.645406 | 0.190 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.645406 | 0.190 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.645406 | 0.190 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.645406 | 0.190 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.645406 | 0.190 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.645406 | 0.190 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.645406 | 0.190 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.645406 | 0.190 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.650782 | 0.187 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.650782 | 0.187 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.650782 | 0.187 |
| R-HSA-9679506 | SARS-CoV Infections | 0.651663 | 0.186 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.655453 | 0.183 |
| R-HSA-9843745 | Adipogenesis | 0.655603 | 0.183 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.656078 | 0.183 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.656078 | 0.183 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.656078 | 0.183 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.657787 | 0.182 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.661294 | 0.180 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.661294 | 0.180 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.666431 | 0.176 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.666431 | 0.176 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.666431 | 0.176 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.668339 | 0.175 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.671490 | 0.173 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 0.676473 | 0.170 |
| R-HSA-9830369 | Kidney development | 0.681380 | 0.167 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 0.681380 | 0.167 |
| R-HSA-72766 | Translation | 0.682757 | 0.166 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.683824 | 0.165 |
| R-HSA-109582 | Hemostasis | 0.684001 | 0.165 |
| R-HSA-6807070 | PTEN Regulation | 0.687216 | 0.163 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.690578 | 0.161 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.690578 | 0.161 |
| R-HSA-9664407 | Parasite infection | 0.690578 | 0.161 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.693910 | 0.159 |
| R-HSA-1632852 | Macroautophagy | 0.693910 | 0.159 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 0.695663 | 0.158 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.695663 | 0.158 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.695663 | 0.158 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.695663 | 0.158 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.695663 | 0.158 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.697522 | 0.156 |
| R-HSA-74160 | Gene expression (Transcription) | 0.698978 | 0.156 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.700280 | 0.155 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.700280 | 0.155 |
| R-HSA-3000178 | ECM proteoglycans | 0.700280 | 0.155 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.700280 | 0.155 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.700280 | 0.155 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.700486 | 0.155 |
| R-HSA-418990 | Adherens junctions interactions | 0.703081 | 0.153 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.704828 | 0.152 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 0.704828 | 0.152 |
| R-HSA-1483257 | Phospholipid metabolism | 0.707337 | 0.150 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.709307 | 0.149 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.709307 | 0.149 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.709307 | 0.149 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.713719 | 0.146 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.713719 | 0.146 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.718064 | 0.144 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 0.718064 | 0.144 |
| R-HSA-8852135 | Protein ubiquitination | 0.718064 | 0.144 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.718064 | 0.144 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.718064 | 0.144 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.722343 | 0.141 |
| R-HSA-216083 | Integrin cell surface interactions | 0.730708 | 0.136 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.730708 | 0.136 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.730708 | 0.136 |
| R-HSA-5619084 | ABC transporter disorders | 0.730708 | 0.136 |
| R-HSA-4086400 | PCP/CE pathway | 0.730708 | 0.136 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.731630 | 0.136 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.731630 | 0.136 |
| R-HSA-9609507 | Protein localization | 0.734589 | 0.134 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.737520 | 0.132 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.738822 | 0.131 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.738822 | 0.131 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.740424 | 0.131 |
| R-HSA-1989781 | PPARA activates gene expression | 0.740424 | 0.131 |
| R-HSA-9612973 | Autophagy | 0.743300 | 0.129 |
| R-HSA-9610379 | HCMV Late Events | 0.746149 | 0.127 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.746149 | 0.127 |
| R-HSA-9711097 | Cellular response to starvation | 0.748971 | 0.126 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.748971 | 0.126 |
| R-HSA-8939211 | ESR-mediated signaling | 0.750783 | 0.124 |
| R-HSA-877300 | Interferon gamma signaling | 0.751766 | 0.124 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.754327 | 0.122 |
| R-HSA-8953854 | Metabolism of RNA | 0.757401 | 0.121 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.765351 | 0.116 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.768915 | 0.114 |
| R-HSA-9663891 | Selective autophagy | 0.772425 | 0.112 |
| R-HSA-5619102 | SLC transporter disorders | 0.773177 | 0.112 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.773326 | 0.112 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.775882 | 0.110 |
| R-HSA-202424 | Downstream TCR signaling | 0.779287 | 0.108 |
| R-HSA-421270 | Cell-cell junction organization | 0.781866 | 0.107 |
| R-HSA-418555 | G alpha (s) signalling events | 0.785730 | 0.105 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.785730 | 0.105 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.785942 | 0.105 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.789195 | 0.103 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.792398 | 0.101 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.792398 | 0.101 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.792966 | 0.101 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.795330 | 0.099 |
| R-HSA-168256 | Immune System | 0.798832 | 0.098 |
| R-HSA-597592 | Post-translational protein modification | 0.799893 | 0.097 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.801720 | 0.096 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.801720 | 0.096 |
| R-HSA-168255 | Influenza Infection | 0.804548 | 0.094 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.805822 | 0.094 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.807702 | 0.093 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.813398 | 0.090 |
| R-HSA-3214847 | HATs acetylate histones | 0.813504 | 0.090 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 0.813504 | 0.090 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.814155 | 0.089 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.816339 | 0.088 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.819131 | 0.087 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 0.824590 | 0.084 |
| R-HSA-111885 | Opioid Signalling | 0.827257 | 0.082 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.832016 | 0.080 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.835921 | 0.078 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.837529 | 0.077 |
| R-HSA-69239 | Synthesis of DNA | 0.837529 | 0.077 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.837529 | 0.077 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.837529 | 0.077 |
| R-HSA-382551 | Transport of small molecules | 0.839361 | 0.076 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.840000 | 0.076 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.840000 | 0.076 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.840000 | 0.076 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.842434 | 0.074 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 0.844831 | 0.073 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.849517 | 0.071 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.849517 | 0.071 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.849517 | 0.071 |
| R-HSA-72172 | mRNA Splicing | 0.855966 | 0.068 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.858470 | 0.066 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.860624 | 0.065 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.862746 | 0.064 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.862746 | 0.064 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.864835 | 0.063 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.876722 | 0.057 |
| R-HSA-5663205 | Infectious disease | 0.877129 | 0.057 |
| R-HSA-977606 | Regulation of Complement cascade | 0.880448 | 0.055 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.882269 | 0.054 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.882269 | 0.054 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.882269 | 0.054 |
| R-HSA-194138 | Signaling by VEGF | 0.882269 | 0.054 |
| R-HSA-69206 | G1/S Transition | 0.882269 | 0.054 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.887567 | 0.052 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.892176 | 0.050 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.895875 | 0.048 |
| R-HSA-8957322 | Metabolism of steroids | 0.896241 | 0.048 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.903572 | 0.044 |
| R-HSA-5368287 | Mitochondrial translation | 0.906489 | 0.043 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.906489 | 0.043 |
| R-HSA-157118 | Signaling by NOTCH | 0.906939 | 0.042 |
| R-HSA-392499 | Metabolism of proteins | 0.911847 | 0.040 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.916025 | 0.038 |
| R-HSA-166658 | Complement cascade | 0.917306 | 0.037 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.918567 | 0.037 |
| R-HSA-166520 | Signaling by NTRKs | 0.921033 | 0.036 |
| R-HSA-9758941 | Gastrulation | 0.922238 | 0.035 |
| R-HSA-69306 | DNA Replication | 0.926876 | 0.033 |
| R-HSA-73887 | Death Receptor Signaling | 0.927992 | 0.032 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.938260 | 0.028 |
| R-HSA-9658195 | Leishmania infection | 0.944329 | 0.025 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.944329 | 0.025 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.944566 | 0.025 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.947068 | 0.024 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.953445 | 0.021 |
| R-HSA-1643685 | Disease | 0.955093 | 0.020 |
| R-HSA-195721 | Signaling by WNT | 0.955205 | 0.020 |
| R-HSA-3781865 | Diseases of glycosylation | 0.955318 | 0.020 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.957989 | 0.019 |
| R-HSA-8978868 | Fatty acid metabolism | 0.959222 | 0.018 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.959888 | 0.018 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 0.961106 | 0.017 |
| R-HSA-428157 | Sphingolipid metabolism | 0.965620 | 0.015 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.966664 | 0.015 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.966664 | 0.015 |
| R-HSA-1474244 | Extracellular matrix organization | 0.970808 | 0.013 |
| R-HSA-168249 | Innate Immune System | 0.974506 | 0.011 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.974733 | 0.011 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.976772 | 0.010 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.976986 | 0.010 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.978029 | 0.010 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.978366 | 0.009 |
| R-HSA-72312 | rRNA processing | 0.979024 | 0.009 |
| R-HSA-15869 | Metabolism of nucleotides | 0.980282 | 0.009 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.980584 | 0.009 |
| R-HSA-556833 | Metabolism of lipids | 0.986023 | 0.006 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.986840 | 0.006 |
| R-HSA-416476 | G alpha (q) signalling events | 0.987215 | 0.006 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.996944 | 0.001 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.997296 | 0.001 |
| R-HSA-388396 | GPCR downstream signalling | 0.998223 | 0.001 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.998333 | 0.001 |
| R-HSA-418594 | G alpha (i) signalling events | 0.998640 | 0.001 |
| R-HSA-5668914 | Diseases of metabolism | 0.999005 | 0.000 |
| R-HSA-372790 | Signaling by GPCR | 0.999373 | 0.000 |
| R-HSA-500792 | GPCR ligand binding | 0.999922 | 0.000 |
| R-HSA-1430728 | Metabolism | 0.999992 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999999 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
MARK2 |
0.836 | 0.541 | 4 | 0.586 |
MARK4 |
0.835 | 0.457 | 4 | 0.503 |
MARK3 |
0.834 | 0.534 | 4 | 0.606 |
QSK |
0.831 | 0.428 | 4 | 0.539 |
AMPKA1 |
0.826 | 0.294 | -3 | 0.889 |
CDC7 |
0.825 | 0.061 | 1 | 0.911 |
NUAK2 |
0.824 | 0.179 | -3 | 0.886 |
SIK |
0.824 | 0.340 | -3 | 0.812 |
MARK1 |
0.823 | 0.456 | 4 | 0.549 |
COT |
0.823 | -0.014 | 2 | 0.889 |
AMPKA2 |
0.823 | 0.263 | -3 | 0.863 |
TSSK1 |
0.823 | 0.260 | -3 | 0.901 |
PIM3 |
0.821 | 0.055 | -3 | 0.873 |
NUAK1 |
0.819 | 0.205 | -3 | 0.841 |
TSSK2 |
0.818 | 0.214 | -5 | 0.890 |
NDR2 |
0.816 | 0.022 | -3 | 0.871 |
QIK |
0.816 | 0.282 | -3 | 0.874 |
CAMK1B |
0.814 | 0.062 | -3 | 0.904 |
BRSK1 |
0.814 | 0.232 | -3 | 0.836 |
NLK |
0.813 | 0.064 | 1 | 0.874 |
PRPK |
0.813 | -0.090 | -1 | 0.788 |
GCN2 |
0.813 | -0.051 | 2 | 0.808 |
CLK3 |
0.813 | 0.039 | 1 | 0.883 |
BRSK2 |
0.813 | 0.245 | -3 | 0.858 |
MOS |
0.813 | -0.003 | 1 | 0.940 |
CDKL1 |
0.812 | 0.053 | -3 | 0.846 |
PRKD1 |
0.812 | 0.031 | -3 | 0.846 |
PIM1 |
0.810 | 0.054 | -3 | 0.836 |
RAF1 |
0.810 | -0.025 | 1 | 0.873 |
PRKD2 |
0.810 | 0.050 | -3 | 0.810 |
IKKB |
0.810 | -0.056 | -2 | 0.794 |
SSTK |
0.809 | 0.315 | 4 | 0.468 |
HIPK4 |
0.808 | 0.095 | 1 | 0.829 |
TBK1 |
0.808 | -0.019 | 1 | 0.747 |
BMPR2 |
0.808 | -0.044 | -2 | 0.905 |
CDKL5 |
0.808 | 0.053 | -3 | 0.838 |
CAMK2G |
0.807 | -0.061 | 2 | 0.812 |
NDR1 |
0.807 | 0.017 | -3 | 0.874 |
ATR |
0.807 | -0.000 | 1 | 0.855 |
MTOR |
0.807 | -0.108 | 1 | 0.818 |
MELK |
0.807 | 0.146 | -3 | 0.850 |
WNK1 |
0.807 | 0.021 | -2 | 0.888 |
PDHK4 |
0.806 | -0.134 | 1 | 0.880 |
ERK5 |
0.806 | 0.029 | 1 | 0.849 |
SRPK1 |
0.806 | 0.051 | -3 | 0.800 |
PKN3 |
0.806 | -0.003 | -3 | 0.867 |
MAPKAPK3 |
0.806 | 0.037 | -3 | 0.814 |
LATS2 |
0.806 | 0.004 | -5 | 0.799 |
RSK2 |
0.806 | 0.021 | -3 | 0.824 |
TGFBR2 |
0.805 | -0.006 | -2 | 0.791 |
NIK |
0.805 | 0.019 | -3 | 0.909 |
DSTYK |
0.805 | -0.068 | 2 | 0.879 |
WNK3 |
0.804 | 0.021 | 1 | 0.847 |
IKKE |
0.804 | -0.045 | 1 | 0.739 |
DAPK2 |
0.804 | 0.037 | -3 | 0.901 |
ULK2 |
0.804 | -0.098 | 2 | 0.795 |
CAMLCK |
0.804 | 0.026 | -2 | 0.854 |
NIM1 |
0.804 | 0.106 | 3 | 0.800 |
P90RSK |
0.803 | 0.018 | -3 | 0.820 |
HUNK |
0.803 | 0.025 | 2 | 0.799 |
CAMK2D |
0.803 | -0.023 | -3 | 0.872 |
SKMLCK |
0.803 | 0.030 | -2 | 0.851 |
RSK3 |
0.802 | 0.022 | -3 | 0.813 |
MST4 |
0.802 | -0.019 | 2 | 0.839 |
PDHK1 |
0.802 | -0.116 | 1 | 0.862 |
CAMK2B |
0.802 | -0.001 | 2 | 0.797 |
PKN2 |
0.801 | -0.004 | -3 | 0.880 |
MAPKAPK2 |
0.801 | 0.024 | -3 | 0.777 |
BCKDK |
0.801 | -0.084 | -1 | 0.743 |
ATM |
0.800 | 0.018 | 1 | 0.788 |
P70S6KB |
0.800 | 0.011 | -3 | 0.847 |
NEK7 |
0.800 | -0.077 | -3 | 0.828 |
NEK6 |
0.800 | -0.085 | -2 | 0.887 |
GRK6 |
0.800 | -0.036 | 1 | 0.878 |
GRK5 |
0.799 | -0.110 | -3 | 0.879 |
ICK |
0.799 | 0.025 | -3 | 0.874 |
CHK1 |
0.799 | 0.080 | -3 | 0.851 |
PKCD |
0.798 | -0.003 | 2 | 0.793 |
RIPK3 |
0.798 | -0.041 | 3 | 0.728 |
SRPK2 |
0.798 | 0.051 | -3 | 0.733 |
CAMK4 |
0.798 | 0.014 | -3 | 0.871 |
MLK1 |
0.798 | -0.065 | 2 | 0.804 |
CAMK2A |
0.798 | -0.005 | 2 | 0.797 |
PRKD3 |
0.798 | 0.048 | -3 | 0.794 |
IKKA |
0.797 | -0.049 | -2 | 0.788 |
SMG1 |
0.797 | 0.077 | 1 | 0.796 |
NEK9 |
0.796 | -0.056 | 2 | 0.846 |
PKACG |
0.796 | -0.002 | -2 | 0.752 |
GRK1 |
0.795 | -0.042 | -2 | 0.775 |
FAM20C |
0.795 | 0.009 | 2 | 0.596 |
IRE1 |
0.795 | -0.046 | 1 | 0.840 |
CHAK2 |
0.795 | -0.065 | -1 | 0.753 |
MASTL |
0.794 | -0.110 | -2 | 0.862 |
SRPK3 |
0.793 | 0.039 | -3 | 0.777 |
LATS1 |
0.793 | -0.007 | -3 | 0.878 |
MEK1 |
0.792 | 0.017 | 2 | 0.840 |
MLK2 |
0.792 | -0.074 | 2 | 0.830 |
GSK3B |
0.792 | -0.067 | 4 | 0.096 |
CDK8 |
0.792 | 0.013 | 1 | 0.698 |
PKR |
0.791 | -0.024 | 1 | 0.889 |
PHKG1 |
0.791 | 0.002 | -3 | 0.866 |
MYLK4 |
0.791 | 0.052 | -2 | 0.758 |
ANKRD3 |
0.791 | -0.060 | 1 | 0.889 |
PIM2 |
0.791 | 0.052 | -3 | 0.804 |
BMPR1B |
0.791 | 0.048 | 1 | 0.859 |
CAMK1G |
0.791 | 0.090 | -3 | 0.818 |
RIPK1 |
0.791 | -0.079 | 1 | 0.853 |
AURC |
0.791 | 0.004 | -2 | 0.629 |
ULK1 |
0.791 | -0.125 | -3 | 0.805 |
DLK |
0.791 | -0.121 | 1 | 0.863 |
IRE2 |
0.791 | -0.020 | 2 | 0.746 |
CDK7 |
0.790 | 0.017 | 1 | 0.721 |
ALK4 |
0.790 | -0.009 | -2 | 0.836 |
TGFBR1 |
0.790 | 0.011 | -2 | 0.807 |
MSK2 |
0.790 | -0.013 | -3 | 0.789 |
KIS |
0.790 | -0.003 | 1 | 0.743 |
CLK1 |
0.789 | 0.044 | -3 | 0.807 |
RSK4 |
0.788 | 0.014 | -3 | 0.795 |
GSK3A |
0.788 | -0.052 | 4 | 0.096 |
PLK1 |
0.788 | -0.057 | -2 | 0.845 |
GRK4 |
0.788 | -0.105 | -2 | 0.824 |
SNRK |
0.787 | 0.048 | 2 | 0.659 |
DYRK2 |
0.787 | 0.026 | 1 | 0.735 |
CLK4 |
0.787 | 0.020 | -3 | 0.827 |
PAK3 |
0.786 | -0.030 | -2 | 0.782 |
MNK2 |
0.786 | -0.025 | -2 | 0.801 |
PKCB |
0.786 | -0.023 | 2 | 0.737 |
PKG2 |
0.786 | 0.019 | -2 | 0.670 |
CDK5 |
0.786 | 0.020 | 1 | 0.740 |
MLK3 |
0.786 | -0.070 | 2 | 0.730 |
MSK1 |
0.786 | -0.001 | -3 | 0.795 |
AURB |
0.785 | 0.007 | -2 | 0.634 |
P38A |
0.785 | 0.043 | 1 | 0.750 |
PKCA |
0.785 | -0.045 | 2 | 0.725 |
VRK2 |
0.785 | -0.079 | 1 | 0.906 |
CDK19 |
0.784 | 0.011 | 1 | 0.659 |
PLK3 |
0.784 | -0.024 | 2 | 0.752 |
CDK2 |
0.784 | 0.027 | 1 | 0.754 |
PKACB |
0.784 | 0.012 | -2 | 0.663 |
ALK2 |
0.784 | 0.000 | -2 | 0.808 |
SGK3 |
0.784 | 0.019 | -3 | 0.815 |
ACVR2A |
0.784 | -0.000 | -2 | 0.791 |
PAK1 |
0.783 | -0.040 | -2 | 0.772 |
YSK4 |
0.783 | -0.071 | 1 | 0.799 |
NEK2 |
0.783 | -0.045 | 2 | 0.812 |
ACVR2B |
0.783 | 0.004 | -2 | 0.808 |
PKCG |
0.783 | -0.058 | 2 | 0.718 |
PAK6 |
0.783 | -0.007 | -2 | 0.694 |
CHAK1 |
0.782 | -0.060 | 2 | 0.763 |
TTBK2 |
0.782 | -0.120 | 2 | 0.699 |
PHKG2 |
0.782 | 0.019 | -3 | 0.855 |
DCAMKL1 |
0.782 | 0.027 | -3 | 0.831 |
MAPKAPK5 |
0.781 | -0.026 | -3 | 0.763 |
CAMK1D |
0.781 | 0.068 | -3 | 0.748 |
DNAPK |
0.781 | -0.029 | 1 | 0.703 |
CDK13 |
0.781 | -0.006 | 1 | 0.690 |
PKCH |
0.781 | -0.047 | 2 | 0.713 |
HRI |
0.781 | -0.050 | -2 | 0.867 |
AKT2 |
0.781 | 0.018 | -3 | 0.753 |
PKCZ |
0.781 | -0.056 | 2 | 0.785 |
JNK2 |
0.780 | 0.029 | 1 | 0.658 |
GRK7 |
0.780 | -0.033 | 1 | 0.803 |
PRKX |
0.780 | 0.020 | -3 | 0.747 |
P38B |
0.780 | 0.046 | 1 | 0.670 |
DYRK1A |
0.780 | 0.038 | 1 | 0.785 |
PAK2 |
0.779 | -0.029 | -2 | 0.759 |
MNK1 |
0.779 | -0.033 | -2 | 0.813 |
CDK1 |
0.779 | 0.010 | 1 | 0.673 |
JNK3 |
0.779 | 0.021 | 1 | 0.691 |
CLK2 |
0.778 | 0.026 | -3 | 0.807 |
WNK4 |
0.778 | -0.038 | -2 | 0.887 |
IRAK4 |
0.778 | -0.033 | 1 | 0.841 |
CDK9 |
0.778 | -0.003 | 1 | 0.697 |
P70S6K |
0.778 | 0.016 | -3 | 0.765 |
MLK4 |
0.778 | -0.096 | 2 | 0.728 |
BRAF |
0.778 | -0.049 | -4 | 0.863 |
PERK |
0.777 | -0.075 | -2 | 0.844 |
CDK18 |
0.776 | -0.006 | 1 | 0.648 |
SMMLCK |
0.776 | 0.007 | -3 | 0.867 |
HIPK1 |
0.776 | 0.033 | 1 | 0.756 |
DRAK1 |
0.776 | -0.054 | 1 | 0.811 |
BMPR1A |
0.776 | 0.028 | 1 | 0.842 |
ERK1 |
0.775 | 0.023 | 1 | 0.661 |
ERK2 |
0.775 | 0.013 | 1 | 0.708 |
DCAMKL2 |
0.775 | 0.016 | -3 | 0.856 |
TLK2 |
0.774 | -0.092 | 1 | 0.807 |
MEKK1 |
0.774 | -0.079 | 1 | 0.842 |
P38G |
0.774 | 0.027 | 1 | 0.584 |
GRK2 |
0.774 | -0.039 | -2 | 0.716 |
CDK12 |
0.774 | -0.005 | 1 | 0.660 |
MEK5 |
0.774 | -0.123 | 2 | 0.823 |
AKT1 |
0.773 | 0.021 | -3 | 0.768 |
HIPK2 |
0.773 | 0.027 | 1 | 0.651 |
MPSK1 |
0.773 | 0.006 | 1 | 0.838 |
PKACA |
0.773 | 0.018 | -2 | 0.607 |
PRP4 |
0.773 | -0.003 | -3 | 0.752 |
PINK1 |
0.773 | -0.081 | 1 | 0.869 |
CK2A2 |
0.773 | 0.028 | 1 | 0.794 |
NEK5 |
0.772 | -0.041 | 1 | 0.864 |
TLK1 |
0.772 | -0.051 | -2 | 0.833 |
PASK |
0.772 | -0.031 | -3 | 0.883 |
CAMK1A |
0.772 | 0.094 | -3 | 0.716 |
PKCT |
0.772 | -0.039 | 2 | 0.733 |
AURA |
0.772 | -0.033 | -2 | 0.596 |
CDK17 |
0.772 | 0.002 | 1 | 0.591 |
IRAK1 |
0.772 | -0.049 | -1 | 0.701 |
HIPK3 |
0.772 | 0.012 | 1 | 0.759 |
MEKK2 |
0.771 | -0.064 | 2 | 0.812 |
GAK |
0.771 | 0.034 | 1 | 0.902 |
MST3 |
0.771 | -0.049 | 2 | 0.812 |
TAO3 |
0.770 | -0.058 | 1 | 0.833 |
DYRK1B |
0.770 | 0.029 | 1 | 0.698 |
ZAK |
0.770 | -0.123 | 1 | 0.807 |
CDK14 |
0.769 | 0.004 | 1 | 0.691 |
DAPK3 |
0.769 | 0.022 | -3 | 0.850 |
PLK4 |
0.769 | -0.074 | 2 | 0.612 |
CDK3 |
0.769 | 0.021 | 1 | 0.612 |
TAO2 |
0.768 | -0.040 | 2 | 0.846 |
MEKK3 |
0.768 | -0.128 | 1 | 0.838 |
DYRK4 |
0.767 | 0.014 | 1 | 0.663 |
ERK7 |
0.767 | 0.028 | 2 | 0.556 |
PKCI |
0.767 | -0.039 | 2 | 0.742 |
DYRK3 |
0.767 | 0.017 | 1 | 0.758 |
CDK10 |
0.767 | 0.013 | 1 | 0.679 |
CHK2 |
0.766 | 0.034 | -3 | 0.704 |
PKN1 |
0.766 | 0.008 | -3 | 0.784 |
CK1E |
0.766 | -0.025 | -3 | 0.598 |
CAMKK1 |
0.764 | -0.092 | -2 | 0.794 |
P38D |
0.764 | 0.029 | 1 | 0.603 |
CDK16 |
0.764 | 0.002 | 1 | 0.608 |
CAMKK2 |
0.764 | -0.061 | -2 | 0.791 |
PAK5 |
0.763 | -0.022 | -2 | 0.625 |
NEK8 |
0.763 | -0.069 | 2 | 0.804 |
CK2A1 |
0.762 | 0.006 | 1 | 0.772 |
SBK |
0.762 | 0.043 | -3 | 0.638 |
MRCKA |
0.762 | 0.030 | -3 | 0.814 |
AKT3 |
0.762 | 0.019 | -3 | 0.688 |
LKB1 |
0.762 | -0.051 | -3 | 0.832 |
PKCE |
0.761 | -0.029 | 2 | 0.699 |
TTBK1 |
0.761 | -0.078 | 2 | 0.605 |
DAPK1 |
0.761 | -0.000 | -3 | 0.837 |
PDK1 |
0.761 | -0.034 | 1 | 0.825 |
MST2 |
0.761 | -0.040 | 1 | 0.834 |
CDK6 |
0.761 | 0.019 | 1 | 0.672 |
VRK1 |
0.761 | -0.009 | 2 | 0.840 |
SGK1 |
0.760 | 0.023 | -3 | 0.676 |
NEK4 |
0.760 | -0.053 | 1 | 0.822 |
NEK11 |
0.760 | -0.127 | 1 | 0.819 |
GCK |
0.760 | -0.042 | 1 | 0.827 |
TNIK |
0.760 | -0.045 | 3 | 0.869 |
CDK4 |
0.760 | 0.012 | 1 | 0.645 |
HGK |
0.760 | -0.043 | 3 | 0.867 |
LOK |
0.759 | -0.016 | -2 | 0.824 |
MRCKB |
0.759 | 0.025 | -3 | 0.799 |
CK1D |
0.759 | -0.015 | -3 | 0.549 |
EEF2K |
0.759 | -0.052 | 3 | 0.858 |
ROCK2 |
0.759 | 0.029 | -3 | 0.839 |
LRRK2 |
0.759 | -0.064 | 2 | 0.834 |
TAK1 |
0.758 | -0.024 | 1 | 0.843 |
MINK |
0.758 | -0.060 | 1 | 0.814 |
GRK3 |
0.758 | -0.050 | -2 | 0.660 |
PAK4 |
0.757 | -0.029 | -2 | 0.626 |
PBK |
0.757 | 0.035 | 1 | 0.835 |
MEKK6 |
0.757 | -0.086 | 1 | 0.826 |
JNK1 |
0.756 | 0.006 | 1 | 0.643 |
NEK1 |
0.756 | -0.031 | 1 | 0.842 |
CK1G1 |
0.756 | -0.043 | -3 | 0.588 |
CK1A2 |
0.756 | -0.015 | -3 | 0.552 |
MEK2 |
0.756 | -0.055 | 2 | 0.821 |
MOK |
0.755 | 0.040 | 1 | 0.772 |
HPK1 |
0.755 | -0.032 | 1 | 0.807 |
PLK2 |
0.755 | -0.045 | -3 | 0.784 |
MST1 |
0.755 | -0.041 | 1 | 0.816 |
PKG1 |
0.755 | 0.027 | -2 | 0.584 |
MAK |
0.755 | 0.044 | -2 | 0.724 |
BUB1 |
0.754 | 0.020 | -5 | 0.802 |
DMPK1 |
0.754 | 0.049 | -3 | 0.823 |
KHS1 |
0.753 | -0.024 | 1 | 0.796 |
MAP3K15 |
0.753 | -0.087 | 1 | 0.793 |
RIPK2 |
0.751 | -0.092 | 1 | 0.769 |
YSK1 |
0.751 | -0.061 | 2 | 0.809 |
KHS2 |
0.750 | -0.021 | 1 | 0.810 |
SLK |
0.750 | -0.057 | -2 | 0.763 |
ROCK1 |
0.747 | 0.031 | -3 | 0.812 |
BIKE |
0.746 | 0.042 | 1 | 0.781 |
NEK3 |
0.746 | -0.083 | 1 | 0.792 |
PDHK3_TYR |
0.746 | 0.065 | 4 | 0.261 |
CRIK |
0.744 | 0.032 | -3 | 0.761 |
TTK |
0.744 | -0.038 | -2 | 0.828 |
STK33 |
0.743 | -0.112 | 2 | 0.588 |
OSR1 |
0.741 | -0.072 | 2 | 0.817 |
HASPIN |
0.740 | -0.032 | -1 | 0.585 |
TAO1 |
0.739 | -0.052 | 1 | 0.753 |
MYO3B |
0.738 | -0.060 | 2 | 0.813 |
TESK1_TYR |
0.737 | -0.039 | 3 | 0.893 |
MAP2K4_TYR |
0.737 | -0.061 | -1 | 0.803 |
PDHK4_TYR |
0.735 | 0.004 | 2 | 0.866 |
MAP2K7_TYR |
0.734 | -0.038 | 2 | 0.841 |
MYO3A |
0.733 | -0.068 | 1 | 0.814 |
MAP2K6_TYR |
0.733 | -0.091 | -1 | 0.791 |
LIMK2_TYR |
0.732 | -0.017 | -3 | 0.902 |
PKMYT1_TYR |
0.732 | -0.081 | 3 | 0.846 |
ASK1 |
0.732 | -0.085 | 1 | 0.777 |
EPHA6 |
0.731 | 0.002 | -1 | 0.803 |
PINK1_TYR |
0.730 | -0.111 | 1 | 0.880 |
AAK1 |
0.730 | 0.053 | 1 | 0.679 |
TXK |
0.729 | 0.081 | 1 | 0.899 |
BMPR2_TYR |
0.729 | -0.080 | -1 | 0.774 |
EPHB4 |
0.729 | 0.005 | -1 | 0.820 |
YANK3 |
0.729 | -0.066 | 2 | 0.373 |
TYRO3 |
0.729 | 0.017 | 3 | 0.791 |
PDHK1_TYR |
0.728 | -0.075 | -1 | 0.804 |
LIMK1_TYR |
0.728 | -0.056 | 2 | 0.846 |
ALPHAK3 |
0.728 | -0.089 | -1 | 0.703 |
DDR1 |
0.727 | -0.055 | 4 | 0.247 |
RET |
0.726 | -0.064 | 1 | 0.829 |
STLK3 |
0.726 | -0.065 | 1 | 0.775 |
ROS1 |
0.725 | -0.027 | 3 | 0.762 |
MST1R |
0.724 | -0.058 | 3 | 0.792 |
TYK2 |
0.724 | -0.084 | 1 | 0.821 |
ABL2 |
0.723 | -0.010 | -1 | 0.781 |
YES1 |
0.723 | 0.003 | -1 | 0.806 |
FGR |
0.722 | -0.033 | 1 | 0.897 |
FER |
0.721 | -0.039 | 1 | 0.907 |
TNNI3K_TYR |
0.720 | 0.011 | 1 | 0.845 |
EPHB1 |
0.720 | -0.008 | 1 | 0.882 |
ABL1 |
0.720 | -0.005 | -1 | 0.778 |
TEC |
0.720 | 0.042 | -1 | 0.771 |
EPHB3 |
0.719 | -0.005 | -1 | 0.817 |
LCK |
0.719 | 0.017 | -1 | 0.785 |
HCK |
0.719 | 0.000 | -1 | 0.796 |
CSF1R |
0.718 | -0.064 | 3 | 0.765 |
JAK2 |
0.718 | -0.094 | 1 | 0.817 |
ITK |
0.718 | -0.004 | -1 | 0.785 |
EPHB2 |
0.718 | 0.004 | -1 | 0.807 |
BLK |
0.718 | 0.051 | -1 | 0.784 |
BTK |
0.717 | 0.019 | -1 | 0.793 |
TNK2 |
0.717 | -0.032 | 3 | 0.723 |
SRMS |
0.717 | -0.028 | 1 | 0.890 |
NEK10_TYR |
0.716 | -0.028 | 1 | 0.694 |
BMX |
0.716 | 0.014 | -1 | 0.733 |
AXL |
0.716 | -0.015 | 3 | 0.753 |
EPHA4 |
0.715 | -0.042 | 2 | 0.739 |
CK1A |
0.715 | -0.053 | -3 | 0.459 |
JAK3 |
0.714 | -0.098 | 1 | 0.809 |
INSRR |
0.714 | -0.085 | 3 | 0.735 |
MERTK |
0.713 | -0.002 | 3 | 0.745 |
TNK1 |
0.713 | -0.054 | 3 | 0.764 |
PDGFRB |
0.712 | -0.095 | 3 | 0.792 |
TEK |
0.712 | -0.024 | 3 | 0.717 |
WEE1_TYR |
0.711 | -0.047 | -1 | 0.729 |
FLT3 |
0.710 | -0.087 | 3 | 0.778 |
JAK1 |
0.710 | -0.052 | 1 | 0.757 |
ALK |
0.710 | -0.047 | 3 | 0.703 |
PTK6 |
0.709 | -0.078 | -1 | 0.732 |
FGFR1 |
0.709 | -0.057 | 3 | 0.748 |
LTK |
0.709 | -0.043 | 3 | 0.718 |
EPHA1 |
0.709 | -0.017 | 3 | 0.731 |
FGFR2 |
0.708 | -0.111 | 3 | 0.778 |
DDR2 |
0.708 | -0.038 | 3 | 0.717 |
EPHA7 |
0.707 | -0.041 | 2 | 0.750 |
KIT |
0.707 | -0.106 | 3 | 0.770 |
FRK |
0.706 | -0.015 | -1 | 0.823 |
EPHA3 |
0.705 | -0.075 | 2 | 0.718 |
KDR |
0.705 | -0.095 | 3 | 0.725 |
MET |
0.705 | -0.094 | 3 | 0.759 |
PDGFRA |
0.704 | -0.127 | 3 | 0.785 |
LYN |
0.704 | -0.021 | 3 | 0.690 |
FYN |
0.704 | -0.017 | -1 | 0.749 |
PTK2B |
0.703 | -0.009 | -1 | 0.776 |
NTRK2 |
0.702 | -0.091 | 3 | 0.730 |
NTRK1 |
0.700 | -0.141 | -1 | 0.782 |
INSR |
0.700 | -0.099 | 3 | 0.711 |
EPHA5 |
0.700 | -0.054 | 2 | 0.729 |
CK1G3 |
0.699 | -0.044 | -3 | 0.412 |
YANK2 |
0.697 | -0.076 | 2 | 0.392 |
NTRK3 |
0.697 | -0.102 | -1 | 0.746 |
ERBB2 |
0.696 | -0.124 | 1 | 0.775 |
FGFR3 |
0.695 | -0.108 | 3 | 0.747 |
FLT1 |
0.695 | -0.125 | -1 | 0.760 |
MATK |
0.695 | -0.081 | -1 | 0.697 |
EPHA8 |
0.694 | -0.072 | -1 | 0.772 |
SRC |
0.694 | -0.052 | -1 | 0.759 |
FLT4 |
0.692 | -0.143 | 3 | 0.718 |
CSK |
0.690 | -0.107 | 2 | 0.752 |
PTK2 |
0.687 | -0.053 | -1 | 0.696 |
MUSK |
0.687 | -0.074 | 1 | 0.673 |
EGFR |
0.686 | -0.093 | 1 | 0.679 |
EPHA2 |
0.685 | -0.080 | -1 | 0.750 |
FGFR4 |
0.684 | -0.098 | -1 | 0.735 |
IGF1R |
0.681 | -0.122 | 3 | 0.652 |
SYK |
0.680 | -0.075 | -1 | 0.700 |
FES |
0.676 | -0.072 | -1 | 0.705 |
CK1G2 |
0.673 | -0.069 | -3 | 0.507 |
ERBB4 |
0.672 | -0.088 | 1 | 0.693 |
ZAP70 |
0.653 | -0.085 | -1 | 0.622 |