Motif 852 (n=231)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A1L170 | C1orf226 | S47 | ochoa | Uncharacterized protein C1orf226 | None |
| A1L390 | PLEKHG3 | S647 | ochoa | Pleckstrin homology domain-containing family G member 3 (PH domain-containing family G member 3) | Plays a role in controlling cell polarity and cell motility by selectively binding newly polymerized actin and activating RAC1 and CDC42 to enhance local actin polymerization. {ECO:0000269|PubMed:27555588}. |
| A1X283 | SH3PXD2B | S491 | ochoa | SH3 and PX domain-containing protein 2B (Adapter protein HOFI) (Factor for adipocyte differentiation 49) (Tyrosine kinase substrate with four SH3 domains) | Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation (By similarity). {ECO:0000250, ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497}. |
| A2RUB1 | MEIOC | S130 | ochoa | Meiosis-specific coiled-coil domain-containing protein MEIOC (Meiosis-specific with coiled-coil domain protein) | Is required for meiosis completion in both male and female germ cells. Confers stability to numerous meiotic mRNAs in gonads allowing proper initiation and progression into meiosis prophase I. The function may involve YTHDC2 and is independent of induction by retinoic acid (RA). Maintains an extended meiotic prophase I by properly promoting the transition from a mitotic to a meiotic cell cycle program by binding transcripts through its interaction with YTHDC2 that regulate the mitotic cell cycle. {ECO:0000250|UniProtKB:A2AG06}. |
| A8MVW0 | FAM171A2 | S669 | ochoa | Protein FAM171A2 | None |
| B4DLN1 | None | S248 | ochoa | Mitochondrial dicarboxylate carrier (Solute carrier family 25 member 10) | Catalyzes the electroneutral exchange or flux of physiologically important metabolites such as dicarboxylates (malonate, malate, succinate), inorganic sulfur-containing anions, and phosphate, across mitochondrial inner membrane. Plays an important role in gluconeogenesis, fatty acid metabolism, urea synthesis, and sulfur metabolism, particularly in liver, by supplying the substrates for the different metabolic processes. Regulates fatty acid release from adipocytes, and contributes to systemic insulin sensitivity. {ECO:0000256|ARBA:ARBA00057945}. |
| O00267 | SUPT5H | S789 | ochoa | Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein) | Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A (PubMed:10075709, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter (PubMed:10075709, PubMed:10199401, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II (PubMed:16214896). TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme (PubMed:16214896). Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (PubMed:16214896). Following phosphorylation by CDK9, DSIF can also positively regulate transcriptional elongation (PubMed:16427012). Required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat (PubMed:10393184, PubMed:10454543, PubMed:11809800, PubMed:9514752). DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences (PubMed:11112772, PubMed:14701750). {ECO:0000269|PubMed:10075709, ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:10421630, ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10757782, ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11112772, ECO:0000269|PubMed:11553615, ECO:0000269|PubMed:11809800, ECO:0000269|PubMed:12653964, ECO:0000269|PubMed:12718890, ECO:0000269|PubMed:14701750, ECO:0000269|PubMed:15136722, ECO:0000269|PubMed:15380072, ECO:0000269|PubMed:16214896, ECO:0000269|PubMed:16427012, ECO:0000269|PubMed:9450929, ECO:0000269|PubMed:9514752, ECO:0000269|PubMed:9857195}. |
| O00750 | PIK3C2B | S87 | ochoa | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (PI3K-C2-beta) (PtdIns-3-kinase C2 subunit beta) (EC 2.7.1.137) (EC 2.7.1.154) (C2-PI3K) (Phosphoinositide 3-kinase-C2-beta) | Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns (PubMed:10805725, PubMed:11533253, PubMed:9830063). Does not phosphorylate PtdIns(4,5)P2 (PubMed:9830063). May be involved in EGF and PDGF signaling cascades (PubMed:10805725). {ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11533253, ECO:0000269|PubMed:9830063}. |
| O00767 | SCD | S198 | ochoa | Stearoyl-CoA desaturase (hSCD1) (EC 1.14.19.1) (Acyl-CoA desaturase) (Delta(9)-desaturase) (Delta-9 desaturase) (Fatty acid desaturase) | Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates (PubMed:15907797, PubMed:18765284). Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:15907797, PubMed:18765284). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed:15610069). Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By similarity). Plays an important role in body energy homeostasis (By similarity). Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (By similarity). {ECO:0000250|UniProtKB:P13516, ECO:0000269|PubMed:15610069, ECO:0000269|PubMed:15907797, ECO:0000269|PubMed:18765284}. |
| O14523 | C2CD2L | S623 | ochoa | Phospholipid transfer protein C2CD2L (C2 domain-containing protein 2-like) (C2CD2-like) (Transmembrane protein 24) | Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane (PubMed:28209843). It thereby maintains the pool of cell membrane phosphoinositides, which are degraded during phospholipase C (PLC) signaling (PubMed:28209843). Plays a key role in the coordination of Ca(2+) and phosphoinositide signaling: localizes to sites of contact between the endoplasmic reticulum and the cell membrane, where it tethers the two bilayers (PubMed:28209843). In response to elevation of cytosolic Ca(2+), it is phosphorylated at its C-terminus and dissociates from the cell membrane, abolishing phosphatidylinositol transport to the cell membrane (PubMed:28209843). Positively regulates insulin secretion in response to glucose: phosphatidylinositol transfer to the cell membrane allows replenishment of PI(4,5)P2 pools and calcium channel opening, priming a new population of insulin granules (PubMed:28209843). {ECO:0000269|PubMed:28209843}. |
| O14526 | FCHO1 | S622 | ochoa | F-BAR domain only protein 1 | Functions in an early step of clathrin-mediated endocytosis (PubMed:30822429). Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors. Involved in the regulation of T-cell poliferation and activation (PubMed:30822429, PubMed:32098969). Affects TCR clustering upon receptor triggering and modulates its internalisation, playing a role in TCR-dependent T-cell activation (PubMed:32098969). {ECO:0000269|PubMed:20448150, ECO:0000269|PubMed:30822429, ECO:0000269|PubMed:32098969}. |
| O14530 | TXNDC9 | S181 | ochoa | Thioredoxin domain-containing protein 9 (ATP-binding protein associated with cell differentiation) (Protein 1-4) | Significantly diminishes the chaperonin TCP1 complex ATPase activity, thus negatively impacts protein folding, including that of actin or tubulin. {ECO:0000269|PubMed:16415341}. |
| O14770 | MEIS2 | S206 | ochoa | Homeobox protein Meis2 (Meis1-related protein 1) | Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3 is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoform 3 and isoform 4 can bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3'; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5'-TGACAG-3'in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate DRD1 transcription; isoform 5 cannot activate DRD1 transcription. {ECO:0000269|PubMed:10764806, ECO:0000269|PubMed:11279116, ECO:0000269|PubMed:21746878}. |
| O14795 | UNC13B | S231 | ochoa | Protein unc-13 homolog B (Munc13-2) (munc13) | Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP) (By similarity). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity). In collaboration with UNC13A, facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (By similarity). {ECO:0000250|UniProtKB:Q9Z1N9}. |
| O14974 | PPP1R12A | S20 | psp | Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) | Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity. {ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:19245366, ECO:0000269|PubMed:20354225}. |
| O15067 | PFAS | S83 | ochoa | Phosphoribosylformylglycinamidine synthase (FGAM synthase) (FGAMS) (EC 6.3.5.3) (Formylglycinamide ribonucleotide amidotransferase) (FGAR amidotransferase) (FGAR-AT) (Formylglycinamide ribotide amidotransferase) (Phosphoribosylformylglycineamide amidotransferase) | Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. {ECO:0000305|PubMed:10548741}. |
| O43166 | SIPA1L1 | S388 | ochoa | Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) | Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}. |
| O43432 | EIF4G3 | S1156 | ochoa|psp | Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:9418880). Functional homolog of EIF4G1 (PubMed:9418880). {ECO:0000269|PubMed:9418880}. |
| O60237 | PPP1R12B | S447 | ochoa | Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase-targeting subunit 2) (Myosin phosphatase target subunit 2) | Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus. {ECO:0000269|PubMed:11067852, ECO:0000269|PubMed:9570949}. |
| O60271 | SPAG9 | S1262 | ochoa | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}. |
| O60716 | CTNND1 | S268 | ochoa|psp | Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) | Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:18343367, ECO:0000269|PubMed:20371349}. |
| O75052 | NOS1AP | S371 | ochoa | Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C-terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein) | Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 (By similarity). In kidney podocytes, plays a role in podosomes and filopodia formation through CDC42 activation (PubMed:33523862). {ECO:0000250|UniProtKB:O54960, ECO:0000269|PubMed:33523862}. |
| O75128 | COBL | S47 | ochoa | Protein cordon-bleu | Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. {ECO:0000250, ECO:0000269|PubMed:21816349}. |
| O75132 | ZBED4 | S254 | ochoa | Zinc finger BED domain-containing protein 4 | Transcriptional regulator that binds to poly-guanine tracts in gene promoters and activates transcription (By similarity). Able to bind single- and double-stranded DNA and RNA (By similarity). {ECO:0000250|UniProtKB:Q80WQ9}. |
| O75145 | PPFIA3 | S512 | ochoa | Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3) | May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269|PubMed:9624153}. |
| O75362 | ZNF217 | S445 | ochoa | Zinc finger protein 217 | Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'. {ECO:0000269|PubMed:16203743, ECO:0000269|PubMed:16940172, ECO:0000269|PubMed:17259635, ECO:0000269|PubMed:18625718}. |
| O75369 | FLNB | S2113 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| O75376 | NCOR1 | S2187 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O75533 | SF3B1 | S349 | ochoa | Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B1 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). {ECO:0000250|UniProtKB:Q99NB9, ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}. |
| O75762 | TRPA1 | S428 | psp | Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Transformation-sensitive protein p120) (p120) (Wasabi receptor) | Ligand-activated Ca(2+)-permeable, nonselective cation channel involved in pain detection and possibly also in cold perception, oxygen concentration perception, cough, itch, and inner ear function (PubMed:17259981, PubMed:21195050, PubMed:21873995, PubMed:23199233, PubMed:25389312, PubMed:33152265). Has a relatively high Ca(2+) selectivity, with a preference for divalent over monovalent cations (Ca(2+) > Ba(2+) > Mg(2+) > NH4(+) > Li(+) > K(+)), the influx of cation into the cytoplasm leads to membrane depolarization (PubMed:19202543, PubMed:21195050). Has a central role in the pain response to endogenous inflammatory mediators, such as bradykinin and to a diverse array of irritants. Activated by a large variety of structurally unrelated electrophilic and non-electrophilic chemical compounds, such as allylthiocyanate (AITC) from mustard oil or wasabi, cinnamaldehyde, diallyl disulfide (DADS) from garlic, and acrolein, an environmental irritant (PubMed:20547126, PubMed:25389312, PubMed:27241698, PubMed:30878828). Electrophilic ligands activate TRPA1 by interacting with critical N-terminal Cys residues in a covalent manner (PubMed:17164327, PubMed:27241698, PubMed:31866091, PubMed:32641835). Non-electrophile agonists bind at distinct sites in the transmembrane domain to promote channel activation (PubMed:33152265). Also acts as an ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana (PubMed:25389312). May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds (By similarity). {ECO:0000250|UniProtKB:Q8BLA8, ECO:0000269|PubMed:17164327, ECO:0000269|PubMed:17259981, ECO:0000269|PubMed:19202543, ECO:0000269|PubMed:20547126, ECO:0000269|PubMed:21195050, ECO:0000269|PubMed:21873995, ECO:0000269|PubMed:23199233, ECO:0000269|PubMed:25389312, ECO:0000269|PubMed:27241698, ECO:0000269|PubMed:30878828, ECO:0000269|PubMed:31866091, ECO:0000269|PubMed:32641835, ECO:0000269|PubMed:33152265}. |
| O75815 | BCAR3 | S395 | ochoa | Breast cancer anti-estrogen resistance protein 3 (Novel SH2-containing protein 2) (SH2 domain-containing protein 3B) | Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers (PubMed:24216110). Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis (PubMed:24216110). Promotes insulin-mediated membrane ruffling (By similarity). In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1 (PubMed:19086031). Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion, actin filament rearrangement, and inhibition of invadopodia activity (By similarity). May inhibit TGFB-SMAD signaling, via facilitating BCAR1 and SMAD2 and/or SMAD3 interaction (By similarity). Regulates EGF-induced DNA synthesis (PubMed:18722344). Required for the maintenance of ocular lens morphology and structural integrity, potentially via regulation of focal adhesion complex signaling (By similarity). Acts upstream of PTPRA to regulate the localization of BCAR1 and PTPRA to focal adhesions, via regulation of SRC-mediated phosphorylation of PTPRA (By similarity). Positively regulates integrin-induced tyrosine phosphorylation of BCAR1 (By similarity). Acts as a guanine nucleotide exchange factor (GEF) for small GTPases RALA, RAP1A and RRAS (By similarity). However, in a contrasting study, lacks GEF activity towards RAP1 (PubMed:22081014). {ECO:0000250|UniProtKB:D3ZAZ5, ECO:0000250|UniProtKB:Q9QZK2, ECO:0000269|PubMed:18722344, ECO:0000269|PubMed:19086031, ECO:0000269|PubMed:22081014, ECO:0000269|PubMed:24216110}. |
| O75962 | TRIO | S520 | ochoa | Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein) | Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed:22155786, PubMed:27418539, PubMed:8643598). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed:10341202, PubMed:22155786). Plays a key role in the regulation of neurite outgrowth and lamellipodia formation (PubMed:32109419). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (By similarity). {ECO:0000250|UniProtKB:F1M0Z1, ECO:0000269|PubMed:10341202, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:27418539, ECO:0000269|PubMed:32109419, ECO:0000269|PubMed:8643598}. |
| O95747 | OXSR1 | S324 | ochoa | Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress-responsive 1 protein) | Effector serine/threonine-protein kinase component of the WNK-SPAK/OSR1 kinase cascade, which is involved in various processes, such as ion transport, response to hypertonic stress and blood pressure (PubMed:16669787, PubMed:18270262, PubMed:21321328, PubMed:34289367). Specifically recognizes and binds proteins with a RFXV motif (PubMed:16669787, PubMed:17721439, PubMed:21321328). Acts downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4): following activation by WNK kinases, catalyzes phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:17721439). Mediates regulatory volume increase in response to hyperosmotic stress by catalyzing phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1 and SLC12A6/KCC3 downstream of WNK1 and WNK3 kinases (PubMed:16669787, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:16669787, PubMed:19665974, PubMed:21321328). Acts as a regulator of NaCl reabsorption in the distal nephron by mediating phosphorylation and activation of the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney downstream of WNK4 (PubMed:18270262). Also acts as a regulator of angiogenesis in endothelial cells downstream of WNK1 (PubMed:23386621, PubMed:25362046). Acts as an activator of inward rectifier potassium channels KCNJ2/Kir2.1 and KCNJ4/Kir2.3 downstream of WNK1: recognizes and binds the RXFXV/I variant motif on KCNJ2/Kir2.1 and KCNJ4/Kir2.3 and regulates their localization to the cell membrane without mediating their phosphorylation (PubMed:29581290). Phosphorylates RELL1, RELL2 and RELT (PubMed:16389068, PubMed:28688764). Phosphorylates PAK1 (PubMed:14707132). Phosphorylates PLSCR1 in the presence of RELT (PubMed:22052202). {ECO:0000269|PubMed:14707132, ECO:0000269|PubMed:16389068, ECO:0000269|PubMed:16669787, ECO:0000269|PubMed:17721439, ECO:0000269|PubMed:18270262, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22052202, ECO:0000269|PubMed:23386621, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:28688764, ECO:0000269|PubMed:29581290, ECO:0000269|PubMed:34289367}. |
| O95835 | LATS1 | S181 | ochoa | Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts) | Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:10518011, PubMed:10831611, PubMed:18158288, PubMed:26437443, PubMed:28068668). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288, PubMed:26437443, PubMed:28068668). Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:18158288, PubMed:26437443, PubMed:28068668). Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint (PubMed:15122335, PubMed:19927127). Negatively regulates G2/M transition by down-regulating CDK1 kinase activity (PubMed:9988268). Involved in the control of p53 expression (PubMed:15122335). Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1 (PubMed:15220930). May also play a role in endocrine function. Plays a role in mammary gland epithelial cell differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1 (PubMed:28068668). Acts as an activator of the NLRP3 inflammasome by mediating phosphorylation of 'Ser-265' of NLRP3 following NLRP3 palmitoylation, promoting NLRP3 activation by NEK7 (PubMed:39173637). {ECO:0000269|PubMed:10518011, ECO:0000269|PubMed:10831611, ECO:0000269|PubMed:15122335, ECO:0000269|PubMed:15220930, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:28068668, ECO:0000269|PubMed:39173637, ECO:0000269|PubMed:9988268}. |
| P00338 | LDHA | S161 | ochoa|psp | L-lactate dehydrogenase A chain (LDH-A) (EC 1.1.1.27) (Cell proliferation-inducing gene 19 protein) (LDH muscle subunit) (LDH-M) (Renal carcinoma antigen NY-REN-59) | Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). {ECO:0000269|PubMed:11276087}. |
| P04818 | TYMS | S114 | ochoa|psp | Thymidylate synthase (TS) (TSase) (EC 2.1.1.45) | Catalyzes the reductive methylation of 2'-deoxyuridine 5'-monophosphate (dUMP) to thymidine 5'-monophosphate (dTMP), using the cosubstrate, 5,10- methylenetetrahydrofolate (CH2H4folate) as a 1-carbon donor and reductant and contributes to the de novo mitochondrial thymidylate biosynthesis pathway. {ECO:0000269|PubMed:11278511, ECO:0000269|PubMed:21876188}. |
| P05177 | CYP1A2 | S82 | ochoa | Cytochrome P450 1A2 (EC 1.14.14.1) (CYPIA2) (Cholesterol 25-hydroxylase) (Cytochrome P(3)450) (Cytochrome P450 4) (Cytochrome P450-P3) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152) | A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:10681376, PubMed:11555828, PubMed:12865317, PubMed:19965576, PubMed:9435160). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:10681376, PubMed:11555828, PubMed:12865317, PubMed:19965576, PubMed:9435160). Catalyzes the hydroxylation of carbon-hydrogen bonds (PubMed:11555828, PubMed:12865317). Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2 (PubMed:11555828, PubMed:12865317). Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis (PubMed:21576599). May act as a major enzyme for all-trans retinoic acid biosynthesis in the liver. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid (PubMed:10681376). Primarily catalyzes stereoselective epoxidation of the last double bond of polyunsaturated fatty acids (PUFA), displaying a strong preference for the (R,S) stereoisomer (PubMed:19965576). Catalyzes bisallylic hydroxylation and omega-1 hydroxylation of PUFA (PubMed:9435160). May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent) (PubMed:21068195). Plays a role in the oxidative metabolism of xenobiotics. Catalyzes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin (PubMed:14725854). Metabolizes caffeine via N3-demethylation (Probable). {ECO:0000269|PubMed:10681376, ECO:0000269|PubMed:11555828, ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:14725854, ECO:0000269|PubMed:19965576, ECO:0000269|PubMed:21068195, ECO:0000269|PubMed:21576599, ECO:0000269|PubMed:9435160, ECO:0000305|PubMed:16522833}. |
| P07195 | LDHB | S162 | ochoa|psp | L-lactate dehydrogenase B chain (LDH-B) (EC 1.1.1.27) (LDH heart subunit) (LDH-H) (Renal carcinoma antigen NY-REN-46) | Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). {ECO:0000269|PubMed:27618187}. |
| P07864 | LDHC | S161 | ochoa | L-lactate dehydrogenase C chain (LDH-C) (EC 1.1.1.27) (Cancer/testis antigen 32) (CT32) (LDH testis subunit) (LDH-X) | Possible role in sperm motility. |
| P08240 | SRPRA | S286 | ochoa | Signal recognition particle receptor subunit alpha (SR-alpha) (Docking protein alpha) (DP-alpha) | Component of the signal recognition particle (SRP) complex receptor (SR) (PubMed:16439358). Ensures, in conjunction with the SRP complex, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (PubMed:16675701, PubMed:34020957). Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SRP subunit SRP54 (PubMed:34020957). SRP receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER (PubMed:34020957). {ECO:0000269|PubMed:16439358, ECO:0000269|PubMed:16675701, ECO:0000269|PubMed:34020957}. |
| P09467 | FBP1 | S170 | psp | Fructose-1,6-bisphosphatase 1 (FBPase 1) (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase 1) (Liver FBPase) | Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain. {ECO:0000269|PubMed:16497803, ECO:0000269|PubMed:18375435, ECO:0000269|PubMed:22517657}. |
| P10398 | ARAF | S157 | ochoa | Serine/threonine-protein kinase A-Raf (EC 2.7.11.1) (Proto-oncogene A-Raf) (Proto-oncogene A-Raf-1) (Proto-oncogene Pks) | Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade. Phosphorylates PFKFB2 (PubMed:36402789). {ECO:0000269|PubMed:22609986, ECO:0000269|PubMed:36402789}.; FUNCTION: [Isoform 2]: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation. {ECO:0000269|PubMed:22609986}. |
| P11274 | BCR | S473 | ochoa | Breakpoint cluster region protein (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-26) | Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed:17116687, PubMed:1903516, PubMed:7479768). The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed:23940119, PubMed:7479768). The amino terminus contains an intrinsic kinase activity (PubMed:1657398). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity (PubMed:17116687). Plays a major role as a RHOA GEF in keratinocytes being involved in focal adhesion formation and keratinocyte differentiation (PubMed:23940119). {ECO:0000250|UniProtKB:Q6PAJ1, ECO:0000269|PubMed:1657398, ECO:0000269|PubMed:17116687, ECO:0000269|PubMed:1903516, ECO:0000269|PubMed:23940119, ECO:0000269|PubMed:7479768}. |
| P13861 | PRKAR2A | S205 | ochoa | cAMP-dependent protein kinase type II-alpha regulatory subunit | Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase. |
| P15056 | BRAF | S394 | ochoa|psp | Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) | Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). Phosphorylates PFKFB2 (PubMed:36402789). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179). {ECO:0000269|PubMed:1508179, ECO:0000269|PubMed:21441910, ECO:0000269|PubMed:29433126, ECO:0000269|PubMed:36402789, ECO:0000305}. |
| P15884 | TCF4 | S87 | ochoa | Transcription factor 4 (TCF-4) (Class B basic helix-loop-helix protein 19) (bHLHb19) (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2) | Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'. {ECO:0000250}. |
| P15924 | DSP | S2526 | ochoa | Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) | Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). {ECO:0000250|UniProtKB:F1LMV6}. |
| P16066 | NPR1 | S529 | psp | Atrial natriuretic peptide receptor 1 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type A) (ANP-A) (ANPR-A) (NPR-A) (Guanylate cyclase A) (GC-A) | Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis (PubMed:39543315). Plays an essential role in the regulation of endothelial cell senescence and vascular aging (PubMed:36016499). Upon activation by ANP or BNP, stimulates the production of cyclic guanosine monophosphate (cGMP) that promotes vascular tone and volume homeostasis by activation of protein kinase cGMP-dependent 1/PRKG1 and subsequently PRKAA1, thereby controlling blood pressure and maintaining cardiovascular homeostasis (PubMed:36016499). {ECO:0000269|PubMed:1672777, ECO:0000269|PubMed:36016499, ECO:0000269|PubMed:39543315}. |
| P16144 | ITGB4 | S1454 | ochoa | Integrin beta-4 (GP150) (CD antigen CD104) | Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:28873464}. |
| P16144 | ITGB4 | S1747 | ochoa | Integrin beta-4 (GP150) (CD antigen CD104) | Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:28873464}. |
| P17600 | SYN1 | S390 | ochoa | Synapsin-1 (Brain protein 4.1) (Synapsin I) | Neuronal phosphoprotein that coats synaptic vesicles, and binds to the cytoskeleton. Acts as a regulator of synaptic vesicles trafficking, involved in the control of neurotransmitter release at the pre-synaptic terminal (PubMed:21441247, PubMed:23406870). Also involved in the regulation of axon outgrowth and synaptogenesis (By similarity). The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level (By similarity). {ECO:0000250|UniProtKB:O88935, ECO:0000250|UniProtKB:P09951, ECO:0000269|PubMed:21441247, ECO:0000269|PubMed:23406870}. |
| P21333 | FLNA | S2158 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P21860 | ERBB3 | S1044 | ochoa | Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3) | Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134). Involved in the regulation of myeloid cell differentiation (PubMed:27416908). {ECO:0000269|PubMed:15358134, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:27416908}. |
| P22234 | PAICS | S274 | ochoa | Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) [Includes: Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) (AIR carboxylase) (AIRC); Phosphoribosylaminoimidazole succinocarboxamide synthetase (EC 6.3.2.6) (SAICAR synthetase)] | Bifunctional phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazole succinocarboxamide synthetase catalyzing two reactions of the de novo purine biosynthetic pathway. {ECO:0000269|PubMed:17224163, ECO:0000269|PubMed:2183217, ECO:0000269|PubMed:31600779}. |
| P25815 | S100P | S24 | ochoa | Protein S100-P (Migration-inducing gene 9 protein) (MIG9) (Protein S100-E) (S100 calcium-binding protein P) | May function as calcium sensor and contribute to cellular calcium signaling. In a calcium-dependent manner, functions by interacting with other proteins, such as EZR and PPP5C, and indirectly plays a role in physiological processes like the formation of microvilli in epithelial cells. May stimulate cell proliferation in an autocrine manner via activation of the receptor for activated glycation end products (RAGE). {ECO:0000269|PubMed:14617629, ECO:0000269|PubMed:19111582, ECO:0000269|PubMed:22399290}. |
| P29728 | OAS2 | S407 | ochoa | 2'-5'-oligoadenylate synthase 2 ((2-5')oligo(A) synthase 2) (2-5A synthase 2) (EC 2.7.7.84) (p69 OAS / p71 OAS) (p69OAS / p71OAS) | Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response (PubMed:10464285, PubMed:9880569). Activated by detection of double stranded RNA (dsRNA): polymerizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNASEL) leading to its dimerization and subsequent activation (PubMed:10464285, PubMed:11682059, PubMed:9880569). Activation of RNASEL leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication (PubMed:10464285, PubMed:9880569). Can mediate the antiviral effect via the classical RNASEL-dependent pathway or an alternative antiviral pathway independent of RNASEL (PubMed:21142819). In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation (PubMed:21142819). May act as a negative regulator of lactation, stopping lactation in virally infected mammary gland lobules, thereby preventing transmission of viruses to neonates (By similarity). Non-infected lobules would not be affected, allowing efficient pup feeding during infection (By similarity). {ECO:0000250|UniProtKB:E9Q9A9, ECO:0000269|PubMed:10464285, ECO:0000269|PubMed:11682059, ECO:0000269|PubMed:19923450, ECO:0000269|PubMed:9880569, ECO:0000303|PubMed:21142819}. |
| P31323 | PRKAR2B | S220 | ochoa | cAMP-dependent protein kinase type II-beta regulatory subunit | Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase. |
| P35367 | HRH1 | S380 | ochoa | Histamine H1 receptor (H1-R) (H1R) (HH1R) | G-protein-coupled receptor for histamine, a biogenic amine that functions as an immune modulator and a neurotransmitter (PubMed:33828102, PubMed:8280179). Through the H1 receptor, histamine mediates the contraction of smooth muscles and increases capillary permeability due to contraction of terminal venules. Also mediates neurotransmission in the central nervous system and thereby regulates circadian rhythms, emotional and locomotor activities as well as cognitive functions (By similarity). {ECO:0000250|UniProtKB:P70174, ECO:0000269|PubMed:33828102, ECO:0000269|PubMed:8280179}. |
| P36897 | TGFBR1 | S189 | psp | TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Activin A receptor type II-like protein kinase of 53kD) (Activin receptor-like kinase 5) (ALK-5) (ALK5) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I) | Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis (PubMed:33914044). The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation. {ECO:0000269|PubMed:15761148, ECO:0000269|PubMed:16754747, ECO:0000269|PubMed:18758450, ECO:0000269|PubMed:33914044, ECO:0000269|PubMed:7774578, ECO:0000269|PubMed:8752209, ECO:0000269|PubMed:8980228, ECO:0000269|PubMed:9346908}. |
| P41587 | VIPR2 | S415 | ochoa | Vasoactive intestinal polypeptide receptor 2 (VIP-R-2) (Helodermin-preferring VIP receptor) (Pituitary adenylate cyclase-activating polypeptide type III receptor) (PACAP type III receptor) (PACAP-R-3) (PACAP-R3) (VPAC2 receptor) (VPAC2R) | G protein-coupled receptor activated by the neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP) (PubMed:7811244, PubMed:35477937, PubMed:8933357). Binds VIP and both PACAP27 and PACAP38 bioactive peptides with the following order of potency PACAP38 = VIP > PACAP27 (PubMed:35477937, PubMed:8933357). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway (PubMed:7811244, PubMed:35477937, PubMed:8933357). May be coupled to phospholipase C. {ECO:0000269|PubMed:35477937, ECO:0000269|PubMed:7811244, ECO:0000269|PubMed:8933357}. |
| P42685 | FRK | S92 | ochoa | Tyrosine-protein kinase FRK (EC 2.7.10.2) (FYN-related kinase) (Nuclear tyrosine protein kinase RAK) (Protein-tyrosine kinase 5) | Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor. {ECO:0000269|PubMed:19345329}. |
| P42704 | LRPPRC | S121 | ochoa | Leucine-rich PPR motif-containing protein, mitochondrial (130 kDa leucine-rich protein) (LRP 130) (GP130) | May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. Positively modulates nuclear export of mRNAs containing the EIF4E sensitivity element (4ESE) by binding simultaneously to both EIF4E and the 4ESE and acting as a platform for assembly for the RNA export complex (PubMed:19262567, PubMed:28325843). Also binds to exportin XPO1/CRM1 to engage the nuclear pore and traffic the bound mRNAs to the cytoplasm (PubMed:28325843). May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA (By similarity). Required for maintaining mitochondrial potential (PubMed:23822101). Suppresses the initiation of basal levels of autophagy and mitophagy by sustaining BCL2 levels (PubMed:23822101). {ECO:0000250, ECO:0000269|PubMed:11585913, ECO:0000269|PubMed:12832482, ECO:0000269|PubMed:15081402, ECO:0000269|PubMed:15139850, ECO:0000269|PubMed:15272088, ECO:0000269|PubMed:17050673, ECO:0000269|PubMed:19262567, ECO:0000269|PubMed:23822101, ECO:0000269|PubMed:28325843}. |
| P48730 | CSNK1D | S382 | ochoa | Casein kinase I isoform delta (CKI-delta) (CKId) (EC 2.7.11.1) (Tau-protein kinase CSNK1D) (EC 2.7.11.26) | Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. Phosphorylates NEDD9/HEF1 (By similarity). EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate. {ECO:0000250|UniProtKB:Q9DC28, ECO:0000269|PubMed:10606744, ECO:0000269|PubMed:12270943, ECO:0000269|PubMed:14761950, ECO:0000269|PubMed:16027726, ECO:0000269|PubMed:17562708, ECO:0000269|PubMed:17962809, ECO:0000269|PubMed:19043076, ECO:0000269|PubMed:20041275, ECO:0000269|PubMed:20048001, ECO:0000269|PubMed:20407760, ECO:0000269|PubMed:20637175, ECO:0000269|PubMed:20696890, ECO:0000269|PubMed:20699359, ECO:0000269|PubMed:21084295, ECO:0000269|PubMed:21422228, ECO:0000269|PubMed:23636092}. |
| P49327 | FASN | S1398 | ochoa | Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] | Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269|PubMed:16215233, ECO:0000269|PubMed:16969344, ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
| P49674 | CSNK1E | S389 | ochoa|psp | Casein kinase I isoform epsilon (CKI-epsilon) (CKIe) (EC 2.7.11.1) | Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (Probable). Participates in Wnt signaling (PubMed:12556519, PubMed:23413191). Phosphorylates DVL1 (PubMed:12556519). Phosphorylates DVL2 (PubMed:23413191). Phosphorylates NEDD9/HEF1 (By similarity). Central component of the circadian clock (PubMed:16790549). In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation (PubMed:15917222, PubMed:16790549). Controls PER1 and PER2 nuclear transport and degradation (By similarity). Inhibits cytokine-induced granuloytic differentiation (PubMed:15070676). {ECO:0000250|UniProtKB:Q9JMK2, ECO:0000269|PubMed:12556519, ECO:0000269|PubMed:15070676, ECO:0000269|PubMed:15917222, ECO:0000269|PubMed:16790549, ECO:0000269|PubMed:23413191, ECO:0000305|PubMed:7797465}. |
| P49790 | NUP153 | S562 | ochoa | Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}. |
| P49792 | RANBP2 | S2844 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P49796 | RGS3 | S992 | ochoa | Regulator of G-protein signaling 3 (RGP3) (RGS3) | Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases. {ECO:0000269|PubMed:10749886, ECO:0000269|PubMed:11294858, ECO:0000269|PubMed:8602223, ECO:0000269|PubMed:9858594}. |
| P50402 | EMD | S29 | ochoa | Emerin | Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Required for proper localization of non-farnesylated prelamin-A/C. Together with NEMP1, contributes to nuclear envelope stiffness in germ cells (PubMed:32923640). EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. {ECO:0000269|PubMed:15328537, ECO:0000269|PubMed:16680152, ECO:0000269|PubMed:16858403, ECO:0000269|PubMed:17785515, ECO:0000269|PubMed:19323649, ECO:0000269|PubMed:32923640}. |
| P50990 | CCT8 | S380 | ochoa | T-complex protein 1 subunit theta (TCP-1-theta) (EC 3.6.1.-) (CCT-theta) (Chaperonin containing T-complex polypeptide 1 subunit 8) (Renal carcinoma antigen NY-REN-15) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P51003 | PAPOLA | S717 | ochoa | Poly(A) polymerase alpha (PAP-alpha) (EC 2.7.7.19) (Polynucleotide adenylyltransferase alpha) | Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus. {ECO:0000269|PubMed:19224921}. |
| P52789 | HK2 | S122 | ochoa | Hexokinase-2 (EC 2.7.1.1) (Hexokinase type II) (HK II) (Hexokinase-B) (Muscle form hexokinase) | Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively) (PubMed:23185017, PubMed:26985301, PubMed:29298880). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:29298880). Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis (PubMed:18350175). {ECO:0000269|PubMed:18350175, ECO:0000269|PubMed:23185017, ECO:0000269|PubMed:26985301, ECO:0000269|PubMed:29298880}. |
| P61978 | HNRNPK | S379 | ochoa|psp | Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP) | One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). {ECO:0000250, ECO:0000269|PubMed:16360036, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:22825850, ECO:0000269|PubMed:33174841}. |
| P78545 | ELF3 | S215 | ochoa | ETS-related transcription factor Elf-3 (E74-like factor 3) (Epithelial-restricted with serine box) (Epithelium-restricted Ets protein ESX) (Epithelium-specific Ets transcription factor 1) (ESE-1) | Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development (By similarity). {ECO:0000250, ECO:0000269|PubMed:10391676, ECO:0000269|PubMed:10644990, ECO:0000269|PubMed:10773884, ECO:0000269|PubMed:11036073, ECO:0000269|PubMed:11313868, ECO:0000269|PubMed:12414801, ECO:0000269|PubMed:12624109, ECO:0000269|PubMed:12682075, ECO:0000269|PubMed:12713734, ECO:0000269|PubMed:14715662, ECO:0000269|PubMed:14767472, ECO:0000269|PubMed:15075319, ECO:0000269|PubMed:15169914, ECO:0000269|PubMed:15794755, ECO:0000269|PubMed:16307850, ECO:0000269|PubMed:17060315, ECO:0000269|PubMed:9129154, ECO:0000269|PubMed:9234700, ECO:0000269|PubMed:9336459, ECO:0000269|PubMed:9395241, ECO:0000269|PubMed:9417054}. |
| Q02818 | NUCB1 | S224 | ochoa | Nucleobindin-1 (CALNUC) | Major calcium-binding protein of the Golgi which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates alpha subunits of guanine nucleotide-binding proteins (G proteins) (By similarity). {ECO:0000250|UniProtKB:Q0P569, ECO:0000250|UniProtKB:Q63083}. |
| Q07955 | SRSF1 | S133 | psp | Serine/arginine-rich splicing factor 1 (Alternative-splicing factor 1) (ASF-1) (Splicing factor, arginine/serine-rich 1) (pre-mRNA-splicing factor SF2, P33 subunit) | Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors. May function as export adapter involved in mRNA nuclear export through the TAP/NXF1 pathway. {ECO:0000269|PubMed:8139654}. |
| Q09666 | AHNAK | S539 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S5739 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q10471 | GALNT2 | S536 | ochoa | Polypeptide N-acetylgalactosaminyltransferase 2 (EC 2.4.1.41) (Polypeptide GalNAc transferase 2) (GalNAc-T2) (pp-GaNTase 2) (Protein-UDP acetylgalactosaminyltransferase 2) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2) [Cleaved into: Polypeptide N-acetylgalactosaminyltransferase 2 soluble form] | Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region. Involved in O-linked glycosylation of APOC-III, ANGPTL3 and PLTP. It participates in the regulation of HDL-C metabolism (PubMed:27508872, PubMed:32293671). {ECO:0000269|PubMed:12438318, ECO:0000269|PubMed:16207894, ECO:0000269|PubMed:16434399, ECO:0000269|PubMed:25939779, ECO:0000269|PubMed:27508872, ECO:0000269|PubMed:32293671, ECO:0000269|PubMed:7592619, ECO:0000269|PubMed:9295285}. |
| Q12888 | TP53BP1 | S1295 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q13242 | SRSF9 | S123 | ochoa | Serine/arginine-rich splicing factor 9 (Pre-mRNA-splicing factor SRp30C) (Splicing factor, arginine/serine-rich 9) | Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269|PubMed:10196175, ECO:0000269|PubMed:11875052, ECO:0000269|PubMed:12024014, ECO:0000269|PubMed:12604611, ECO:0000269|PubMed:15009090, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:15695522, ECO:0000269|PubMed:7556075}. |
| Q13393 | PLD1 | S626 | ochoa | Phospholipase D1 (PLD 1) (hPLD1) (EC 3.1.4.4) (Choline phosphatase 1) (Phosphatidylcholine-hydrolyzing phospholipase D1) | Function as phospholipase selective for phosphatidylcholine (PubMed:25936805, PubMed:8530346, PubMed:9582313). Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity). {ECO:0000250|UniProtKB:Q9Z280, ECO:0000269|PubMed:25936805, ECO:0000269|PubMed:8530346, ECO:0000269|PubMed:9582313}. |
| Q13422 | IKZF1 | S258 | ochoa | DNA-binding protein Ikaros (Ikaros family zinc finger protein 1) (Lymphoid transcription factor LyF-1) | Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067). {ECO:0000250|UniProtKB:Q03267, ECO:0000269|PubMed:10204490, ECO:0000269|PubMed:17135265, ECO:0000269|PubMed:17934067, ECO:0000269|PubMed:19141594}. |
| Q13586 | STIM1 | S512 | ochoa|psp | Stromal interaction molecule 1 | Acts as a Ca(2+) sensor that gates two major inward rectifying Ca(2+) channels at the plasma membrane: Ca(2+) release-activated Ca(2+) (CRAC) channels and arachidonate-regulated Ca(2+)-selective (ARC) channels (PubMed:15866891, PubMed:16005298, PubMed:16208375, PubMed:16537481, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:18854159, PubMed:19182790, PubMed:19249086, PubMed:19622606, PubMed:19706554, PubMed:22464749, PubMed:24069340, PubMed:24351972, PubMed:24591628, PubMed:25326555, PubMed:26322679, PubMed:28219928, PubMed:32415068). Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates CRAC channel pore-forming subunits ORA1, ORA2 and ORAI3 to generate sustained and oscillatory Ca(2+) entry (PubMed:16208375, PubMed:16537481, PubMed:32415068). Involved in enamel formation (PubMed:24621671). {ECO:0000269|PubMed:15866891, ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16208375, ECO:0000269|PubMed:16537481, ECO:0000269|PubMed:16733527, ECO:0000269|PubMed:16766533, ECO:0000269|PubMed:16807233, ECO:0000269|PubMed:18854159, ECO:0000269|PubMed:19182790, ECO:0000269|PubMed:19249086, ECO:0000269|PubMed:19622606, ECO:0000269|PubMed:19706554, ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:24069340, ECO:0000269|PubMed:24351972, ECO:0000269|PubMed:24591628, ECO:0000269|PubMed:24621671, ECO:0000269|PubMed:25326555, ECO:0000269|PubMed:26322679, ECO:0000269|PubMed:28219928, ECO:0000269|PubMed:32415068}. |
| Q14315 | FLNC | S2152 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q14669 | TRIP12 | S1113 | ochoa | E3 ubiquitin-protein ligase TRIP12 (EC 2.3.2.26) (E3 ubiquitin-protein ligase for Arf) (ULF) (HECT-type E3 ubiquitin transferase TRIP12) (Thyroid receptor-interacting protein 12) (TR-interacting protein 12) (TRIP-12) | E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair (PubMed:19028681, PubMed:22884692). Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins (PubMed:19028681). Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress (PubMed:20208519). In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation (PubMed:20208519). Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A (PubMed:20208519). Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation (PubMed:18627766). Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins (PubMed:20829358). Mediates ubiquitination of ASXL1: following binding to N(6)-methyladenosine methylated DNA, ASXL1 is ubiquitinated by TRIP12, leading to its degradation and subsequent inactivation of the PR-DUB complex (PubMed:30982744). {ECO:0000269|PubMed:18627766, ECO:0000269|PubMed:19028681, ECO:0000269|PubMed:20208519, ECO:0000269|PubMed:20829358, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:30982744}. |
| Q14761 | PTPRCAP | S172 | ochoa|psp | Protein tyrosine phosphatase receptor type C-associated protein (PTPRC-associated protein) (CD45-associated protein) (CD45-AP) (Lymphocyte phosphatase-associated phosphoprotein) | None |
| Q14940 | SLC9A5 | S577 | psp | Sodium/hydrogen exchanger 5 (Na(+)/H(+) exchanger 5) (NHE-5) (Solute carrier family 9 member 5) | Plasma membrane Na(+)/H(+) antiporter. Mediates the electroneutral exchange of intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry, thus regulating intracellular pH homeostasis, in particular in neural tissues (PubMed:10692428, PubMed:19276089, PubMed:24936055, PubMed:9933641). Acts as a negative regulator of dendritic spine growth (PubMed:21551074). Plays a role in postsynaptic remodeling and signaling (PubMed:21551074, PubMed:24006492). Can also contribute to organellar pH regulation, with consequences for receptor tyrosine kinase trafficking (PubMed:24936055). {ECO:0000269|PubMed:10692428, ECO:0000269|PubMed:19276089, ECO:0000269|PubMed:21551074, ECO:0000269|PubMed:24006492, ECO:0000269|PubMed:24936055, ECO:0000269|PubMed:9933641}. |
| Q15018 | ABRAXAS2 | S354 | ochoa | BRISC complex subunit Abraxas 2 (Abraxas brother protein 1) (Protein FAM175B) | Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates (PubMed:19214193, PubMed:20032457, PubMed:20656690, PubMed:24075985). May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm (PubMed:20656690). Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins (By similarity). Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression (PubMed:24075985, PubMed:26344097). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). Required for normal induction of p53/TP53 in response to DNA damage (PubMed:25283148). Independent of the BRISC complex, promotes interaction between USP7 and p53/TP53, and thereby promotes deubiquitination of p53/TP53, preventing its degradation and resulting in increased p53/TP53-mediated transcription regulation and p53/TP53-dependent apoptosis in response to DNA damage (PubMed:25283148). {ECO:0000250|UniProtKB:Q3TCJ1, ECO:0000269|PubMed:19214193, ECO:0000269|PubMed:20032457, ECO:0000269|PubMed:20656690, ECO:0000269|PubMed:24075985, ECO:0000269|PubMed:25283148}. |
| Q15149 | PLEC | S3580 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q15172 | PPP2R5A | S49 | ochoa | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (PP2A B subunit isoform B'-alpha) (PP2A B subunit isoform B56-alpha) (PP2A B subunit isoform PR61-alpha) (PR61alpha) (PP2A B subunit isoform R5-alpha) | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. |
| Q15599 | NHERF2 | S280 | ochoa | Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (NHE3 kinase A regulatory protein E3KARP) (SRY-interacting protein 1) (SIP-1) (Sodium-hydrogen exchanger regulatory factor 2) (Solute carrier family 9 isoform A3 regulatory factor 2) (Tyrosine kinase activator protein 1) (TKA-1) | Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3 (PubMed:18829453). May also act as scaffold protein in the nucleus. {ECO:0000269|PubMed:10455146, ECO:0000269|PubMed:18829453, ECO:0000269|PubMed:9096337}. |
| Q15648 | MED1 | S207 | ochoa | Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}. |
| Q15648 | MED1 | S953 | ochoa|psp | Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}. |
| Q15678 | PTPN14 | S593 | ochoa | Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez) | Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor. {ECO:0000269|PubMed:10934049, ECO:0000269|PubMed:12808048, ECO:0000269|PubMed:17893246, ECO:0000269|PubMed:20826270, ECO:0000269|PubMed:22233626, ECO:0000269|PubMed:22525271, ECO:0000269|PubMed:22948661}. |
| Q2KJY2 | KIF26B | S984 | ochoa | Kinesin-like protein KIF26B | Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity). {ECO:0000250}. |
| Q2LD37 | BLTP1 | S2300 | ochoa | Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein) | Tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (Probable). Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as a regulator of phagocytosis (PubMed:31540829). {ECO:0000269|PubMed:30906834, ECO:0000269|PubMed:31540829, ECO:0000305|PubMed:35015055, ECO:0000305|PubMed:35491307}. |
| Q2M1Z3 | ARHGAP31 | S387 | ochoa | Rho GTPase-activating protein 31 (Cdc42 GTPase-activating protein) | Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading, polarized lamellipodia formation and cell migration. {ECO:0000269|PubMed:12192056, ECO:0000269|PubMed:16519628}. |
| Q2TAZ0 | ATG2A | S1402 | ochoa | Autophagy-related protein 2 homolog A | Lipid transfer protein involved in autophagosome assembly (PubMed:28561066, PubMed:30952800, PubMed:31271352). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (PubMed:30952800, PubMed:31271352). Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion (PubMed:30952800, PubMed:31271352). Lipid transfer activity is enhanced by WIPI1 and WDR45/WIPI4, which promote ATG2A-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PubMed:31271352). Also regulates lipid droplets morphology and distribution within the cell (PubMed:22219374, PubMed:28561066). {ECO:0000269|PubMed:22219374, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:30952800, ECO:0000269|PubMed:31271352}. |
| Q32MZ4 | LRRFIP1 | S78 | ochoa | Leucine-rich repeat flightless-interacting protein 1 (LRR FLII-interacting protein 1) (GC-binding factor 2) (TAR RNA-interacting protein) | Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:10364563, ECO:0000269|PubMed:14522076, ECO:0000269|PubMed:16199883, ECO:0000269|PubMed:19265123, ECO:0000269|PubMed:9705290}. |
| Q4KMP7 | TBC1D10B | S248 | ochoa | TBC1 domain family member 10B (Rab27A-GAP-beta) | Acts as a GTPase-activating protein for RAB3A, RAB22A, RAB27A, and RAB35. Does not act on RAB2A and RAB6A. {ECO:0000269|PubMed:16923811, ECO:0000269|PubMed:19077034}. |
| Q53GG5 | PDLIM3 | S252 | ochoa | PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha-actinin-2-associated LIM protein) | May play a role in the organization of actin filament arrays within muscle cells. {ECO:0000250}. |
| Q5TBA9 | FRY | S2507 | ochoa | Protein furry homolog | Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity by promoting PLK1 activity at the spindle poles in early mitosis. May function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation. {ECO:0000269|PubMed:22753416}. |
| Q5VT25 | CDC42BPA | S222 | psp | Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha) | Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration (PubMed:15723050, PubMed:9092543, PubMed:9418861). Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates: PPP1R12A, LIMK1 and LIMK2 (PubMed:11340065, PubMed:11399775). May play a role in TFRC-mediated iron uptake (PubMed:20188707). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). Triggers the formation of an extrusion apical actin ring required for epithelial extrusion of apoptotic cells (PubMed:29162624). {ECO:0000250|UniProtKB:Q3UU96, ECO:0000269|PubMed:11340065, ECO:0000269|PubMed:11399775, ECO:0000269|PubMed:15723050, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:20188707, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:29162624, ECO:0000269|PubMed:9092543, ECO:0000269|PubMed:9418861}. |
| Q5VUB5 | FAM171A1 | S723 | ochoa | Protein FAM171A1 (Astroprincin) (APCN) | Involved in the regulation of the cytoskeletal dynamics, plays a role in actin stress fiber formation. {ECO:0000269|PubMed:30312582}. |
| Q5ZPR3 | CD276 | S513 | ochoa | CD276 antigen (4Ig-B7-H3) (B7 homolog 3) (B7-H3) (Costimulatory molecule) (CD antigen CD276) | May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling. {ECO:0000269|PubMed:11224528, ECO:0000269|PubMed:12906861, ECO:0000269|PubMed:14764704, ECO:0000269|PubMed:15314238, ECO:0000269|PubMed:15682454, ECO:0000269|PubMed:15961727}. |
| Q63HR2 | TNS2 | S102 | ochoa | Tensin-2 (EC 3.1.3.48) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase) | Tyrosine-protein phosphatase which regulates cell motility, proliferation and muscle-response to insulin (PubMed:15817639, PubMed:23401856). Phosphatase activity is mediated by binding to phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3) via the SH2 domain (PubMed:30092354). In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy (PubMed:23401856, PubMed:30092354). Negatively regulates PI3K-AKT pathway activation (PubMed:15817639, PubMed:23401856, PubMed:30092354). Dephosphorylates nephrin NPHS1 in podocytes which regulates activity of the mTORC1 complex (PubMed:28955049). Under normal glucose conditions, NPHS1 outcompetes IRS1 for binding to phosphatidylinositol 3-kinase (PI3K) which balances mTORC1 activity but high glucose conditions lead to up-regulation of TNS2, increased NPHS1 dephosphorylation and activation of mTORC1, contributing to podocyte hypertrophy and proteinuria (PubMed:28955049). Required for correct podocyte morphology, podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in promoting DLC1-dependent remodeling of the extracellular matrix (PubMed:20069572). {ECO:0000250|UniProtKB:Q8CGB6, ECO:0000269|PubMed:15817639, ECO:0000269|PubMed:20069572, ECO:0000269|PubMed:23401856, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:28955049, ECO:0000269|PubMed:30092354}. |
| Q68CZ2 | TNS3 | Y823 | ochoa | Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6) | May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex (PubMed:17643115). EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1 (PubMed:17643115). Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA (PubMed:26166433). Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration (PubMed:35687021). Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1 (PubMed:31905841). {ECO:0000250|UniProtKB:Q5SSZ5, ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:31905841, ECO:0000269|PubMed:35687021, ECO:0000305}. |
| Q6ICG6 | KIAA0930 | S362 | ochoa | Uncharacterized protein KIAA0930 | None |
| Q6P2E9 | EDC4 | S565 | ochoa | Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls) | In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). {ECO:0000269|PubMed:16364915}. |
| Q6P5W5 | SLC39A4 | S469 | ochoa | Zinc transporter ZIP4 (Solute carrier family 39 member 4) (Zrt- and Irt-like protein 4) (ZIP-4) | Selective transporter that mediates the uptake of Zn(2+) (PubMed:17202136, PubMed:22242765, PubMed:27321477, PubMed:28875161, PubMed:31164399, PubMed:31914589, PubMed:31979155, PubMed:33837739, PubMed:36473915). Plays an essential role for dietary zinc uptake from small intestine (By similarity). The Zn(2+) uniporter activity is regulated by zinc availability (PubMed:17202136, PubMed:32348750). Also exhibits polyspecific binding and transport of Cu(2+), Cd(2+) and possibly Ni(2+) but at higher concentrations (PubMed:22242765, PubMed:31914589). {ECO:0000250|UniProtKB:Q78IQ7, ECO:0000269|PubMed:17202136, ECO:0000269|PubMed:22242765, ECO:0000269|PubMed:27321477, ECO:0000269|PubMed:28875161, ECO:0000269|PubMed:31164399, ECO:0000269|PubMed:31914589, ECO:0000269|PubMed:31979155, ECO:0000269|PubMed:32348750, ECO:0000269|PubMed:33837739, ECO:0000269|PubMed:36473915}. |
| Q6P995 | FAM171B | S688 | ochoa | Protein FAM171B | None |
| Q6R327 | RICTOR | S1292 | ochoa | Rapamycin-insensitive companion of mTOR (AVO3 homolog) (hAVO3) | Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15268862, PubMed:15718470, PubMed:19720745, PubMed:19995915, PubMed:21343617, PubMed:33158864, PubMed:35904232, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:19720745, PubMed:19935711, PubMed:19995915). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:15467718, PubMed:21343617). Within the mTORC2 complex, RICTOR probably acts as a molecular adapter (PubMed:21343617, PubMed:33158864, PubMed:35926713). RICTOR is responsible for the FKBP12-rapamycin-insensitivity of mTORC2 (PubMed:33158864). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:15718470, PubMed:19720745, PubMed:19935711, PubMed:35926713). mTORC2 catalyzes the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657' (By similarity). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:15467718). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (PubMed:15467718). {ECO:0000250|UniProtKB:Q6QI06, ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15718470, ECO:0000269|PubMed:19720745, ECO:0000269|PubMed:19935711, ECO:0000269|PubMed:19995915, ECO:0000269|PubMed:21343617, ECO:0000269|PubMed:33158864, ECO:0000269|PubMed:35904232, ECO:0000269|PubMed:35926713}. |
| Q6UUV7 | CRTC3 | S273 | ochoa | CREB-regulated transcription coactivator 3 (Transducer of regulated cAMP response element-binding protein 3) (TORC-3) (Transducer of CREB protein 3) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:15466468, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223, ECO:0000269|PubMed:17644518}. |
| Q6UXY8 | TMC5 | S184 | ochoa | Transmembrane channel-like protein 5 | Probable component of an ion channel (Probable). Molecular function hasn't been characterized yet (Probable). {ECO:0000305}. |
| Q6ZMR3 | LDHAL6A | S161 | ochoa | L-lactate dehydrogenase A-like 6A (LDHA-like protein 6A) (EC 1.1.1.27) | Catalyzes the interconversion of L-lactate and pyruvate with nicotinamide adenine dinucleotide NAD(+) as a coenzyme (PubMed:18351441). Significantly increases the transcriptional activity of JUN, when overexpressed. {ECO:0000269|PubMed:18351441}. |
| Q6ZVL6 | KIAA1549L | S1581 | ochoa | UPF0606 protein KIAA1549L | None |
| Q70CQ2 | USP34 | S1461 | ochoa | Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.4.19.12) (Deubiquitinating enzyme 34) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) | Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. {ECO:0000269|PubMed:21383061}. |
| Q70EL1 | USP54 | S1250 | ochoa | Ubiquitin carboxyl-terminal hydrolase 54 (EC 3.4.19.12) (Ubiquitin-specific peptidase 54) | Deubiquitinase that specifically mediates 'Lys-63'-linked deubiquitination of substrates with a polyubiquitin chain composed of at least 3 ubiquitins (PubMed:39587316). Specifically recognizes ubiquitin chain in position S2 and catalyzes cleavage of polyubiquitin within 'Lys-63'-linked chains (PubMed:39587316). Not able to deubiquitinate substrates with shorter ubiquitin chains (PubMed:39587316). Mediates deubiquitination of PLK4, maintaining PLK4 stability by reducing its ubiquitination-mediated degradation (PubMed:36590171). {ECO:0000269|PubMed:36590171, ECO:0000269|PubMed:39587316}. |
| Q71F56 | MED13L | S806 | ochoa | Mediator of RNA polymerase II transcription subunit 13-like (Mediator complex subunit 13-like) (Thyroid hormone receptor-associated protein 2) (Thyroid hormone receptor-associated protein complex 240 kDa component-like) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. |
| Q7Z2W4 | ZC3HAV1 | S335 | ochoa | Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP) | Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). {ECO:0000269|PubMed:18225958, ECO:0000269|PubMed:21102435, ECO:0000269|PubMed:21876179, ECO:0000269|PubMed:22720057}. |
| Q7Z3G6 | PRICKLE2 | S543 | ochoa | Prickle-like protein 2 | None |
| Q7Z3G6 | PRICKLE2 | S740 | ochoa | Prickle-like protein 2 | None |
| Q7Z434 | MAVS | S401 | ochoa | Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA) | Adapter required for innate immune defense against viruses (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:21170385, PubMed:23087404, PubMed:27992402, PubMed:33139700, PubMed:37582970). Acts downstream of DHX33, RIGI and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFNB and RANTES (CCL5) (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:20628368, PubMed:21170385, PubMed:23087404, PubMed:25636800, PubMed:27736772, PubMed:33110251). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state (PubMed:20451243). Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response (PubMed:20451243). May activate the same pathways following detection of extracellular dsRNA by TLR3 (PubMed:16153868). May protect cells from apoptosis (PubMed:16125763). Involved in NLRP3 inflammasome activation by mediating NLRP3 recruitment to mitochondria (PubMed:23582325). {ECO:0000269|PubMed:16125763, ECO:0000269|PubMed:16127453, ECO:0000269|PubMed:16153868, ECO:0000269|PubMed:16177806, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20451243, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:23087404, ECO:0000269|PubMed:23582325, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:27992402, ECO:0000269|PubMed:33110251, ECO:0000269|PubMed:33139700, ECO:0000269|PubMed:37582970}. |
| Q7Z5J4 | RAI1 | S916 | ochoa | Retinoic acid-induced protein 1 | Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. {ECO:0000269|PubMed:22578325}. |
| Q7Z6E9 | RBBP6 | S1261 | ochoa | E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis) | E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). {ECO:0000250|UniProtKB:P97868, ECO:0000269|PubMed:18851979, ECO:0000269|PubMed:24726359}.; FUNCTION: (Microbial infection) [Isoform 1]: Restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription. {ECO:0000269|PubMed:30550789}. |
| Q7Z6I6 | ARHGAP30 | S240 | ochoa | Rho GTPase-activating protein 30 (Rho-type GTPase-activating protein 30) | GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. {ECO:0000269|PubMed:21565175}. |
| Q7Z6I8 | C5orf24 | S144 | ochoa | UPF0461 protein C5orf24 | None |
| Q7Z6Z7 | HUWE1 | S927 | psp | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q86T24 | ZBTB33 | S264 | ochoa | Transcriptional regulator Kaiso (Zinc finger and BTB domain-containing protein 33) | Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2. Represses expression of MMP7 in conjunction with transcriptional corepressors CBFA2T3, CBFA2T2 and RUNX1T1 (PubMed:23251453). {ECO:0000269|PubMed:11445535, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:15548582, ECO:0000269|PubMed:15817151, ECO:0000269|PubMed:16354688, ECO:0000269|PubMed:23251453}. |
| Q86TI0 | TBC1D1 | S565 | ochoa|psp | TBC1 domain family member 1 | May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity). {ECO:0000250}. |
| Q86VM9 | ZC3H18 | S34 | ochoa | Zinc finger CCCH domain-containing protein 18 (Nuclear protein NHN1) | None |
| Q86VY9 | TMEM200A | S384 | ochoa | Transmembrane protein 200A | None |
| Q86YS3 | RAB11FIP4 | S324 | ochoa | Rab11 family-interacting protein 4 (FIP4-Rab11) (Rab11-FIP4) (Arfophilin-2) | Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abscission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. In case of infection by HCMV (human cytomegalovirus), may participate in egress of the virus out of nucleus; this function is independent of ARF6. {ECO:0000269|PubMed:12470645}. |
| Q86YV5 | PRAG1 | S759 | ochoa | Inactive tyrosine-protein kinase PRAG1 (PEAK1-related kinase-activating pseudokinase 1) (Pragmin) (Sugen kinase 223) (SgK223) | Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling (By similarity). {ECO:0000250|UniProtKB:D3ZMK9, ECO:0000250|UniProtKB:Q571I4}. |
| Q8IW93 | ARHGEF19 | S350 | ochoa | Rho guanine nucleotide exchange factor 19 (Ephexin-2) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPase. {ECO:0000250}. |
| Q8IWU2 | LMTK2 | S561 | ochoa | Serine/threonine-protein kinase LMTK2 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase 2) (Brain-enriched kinase) (hBREK) (CDK5/p35-regulated kinase) (CPRK) (Kinase/phosphatase/inhibitor 2) (Lemur tyrosine kinase 2) (Serine/threonine-protein kinase KPI-2) | Phosphorylates PPP1C, phosphorylase b and CFTR. |
| Q8IY22 | CMIP | S660 | ochoa | C-Maf-inducing protein (c-Mip) (Truncated c-Maf-inducing protein) (Tc-Mip) | Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor. {ECO:0000269|PubMed:12939343, ECO:0000269|PubMed:15128042}. |
| Q8N1K5 | THEMIS | S611 | ochoa | Protein THEMIS (Thymocyte-expressed molecule involved in selection) | Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk. {ECO:0000250|UniProtKB:Q8BGW0}. |
| Q8N3D4 | EHBP1L1 | S462 | ochoa | EH domain-binding protein 1-like protein 1 | May act as Rab effector protein and play a role in vesicle trafficking. {ECO:0000305|PubMed:27552051}. |
| Q8N4N8 | KIF2B | S616 | psp | Kinesin-like protein KIF2B | Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement. Has microtubule depolymerization activity (PubMed:17538014). Plays a role in chromosome congression (PubMed:23891108). {ECO:0000269|PubMed:17538014, ECO:0000269|PubMed:23891108}. |
| Q8N9U0 | TC2N | S156 | ochoa | Tandem C2 domains nuclear protein (Membrane targeting tandem C2 domain-containing protein 1) (Tandem C2 protein in nucleus) (Tac2-N) | None |
| Q8ND25 | ZNRF1 | S120 | ochoa | E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (Nerve injury-induced gene 283 protein) (RING-type E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1) | E3 ubiquitin-protein ligase that plays a role in different processes including cell differentiation, receptor recycling or regulation of inflammation (PubMed:28593998, PubMed:33996800, PubMed:37158982). Mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes neurodegeneration by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons. Ubiquitinates the Na(+)/K(+) ATPase alpha-1 subunit/ATP1A1 and thereby influences its endocytosis and/or degradation (PubMed:22797923). Controls ligand-induced EGFR signaling via mediating receptor ubiquitination and recruitment of the ESCRT machinery (PubMed:33996800). Acts as a negative feedback mechanism controlling TLR3 trafficking by mediating TLR3 'Lys-63'-linked polyubiquitination to reduce type I IFN production (PubMed:37158982). Modulates inflammation by promoting caveolin-1/CAV1 ubiquitination and degradation to regulate TLR4-activated immune response (PubMed:28593998). {ECO:0000269|PubMed:22797923, ECO:0000269|PubMed:28593998, ECO:0000269|PubMed:29626159, ECO:0000269|PubMed:33996800, ECO:0000269|PubMed:37158982, ECO:0000305|PubMed:14561866}. |
| Q8NE01 | CNNM3 | S673 | ochoa | Metal transporter CNNM3 (Ancient conserved domain-containing protein 3) (Cyclin-M3) | Probable metal transporter. {ECO:0000250}. |
| Q8NFA0 | USP32 | S1454 | ochoa | Ubiquitin carboxyl-terminal hydrolase 32 (EC 3.4.19.12) (Deubiquitinating enzyme 32) (Renal carcinoma antigen NY-REN-60) (Ubiquitin thioesterase 32) (Ubiquitin-specific-processing protease 32) | Deubiquitinase that can remove conjugated ubiquitin from target proteins, such as RAB7A and LAMTOR1 (PubMed:36476874). Acts as a positive regulator of the mTORC1 signaling by mediating deubiquitination of LAMTOR1, thereby promoting the association between LAMTOR1 and the lysosomal V-ATPase complex and subsequent activation of the mTORC1 complex (PubMed:36476874). {ECO:0000269|PubMed:36476874}. |
| Q8TBE0 | BAHD1 | S545 | ochoa | Bromo adjacent homology domain-containing 1 protein (BAH domain-containing protein 1) | Heterochromatin protein that acts as a transcription repressor and has the ability to promote the formation of large heterochromatic domains. May act by recruiting heterochromatin proteins such as CBX5 (HP1 alpha), HDAC5 and MBD1. Represses IGF2 expression by binding to its CpG-rich P3 promoter and recruiting heterochromatin proteins. At specific stages of Listeria infection, in complex with TRIM28, corepresses interferon-stimulated genes, including IFNL1, IFNL2 and IFNL3. {ECO:0000269|PubMed:19666599, ECO:0000269|PubMed:21252314}. |
| Q8TCG2 | PI4K2B | S45 | ochoa | Phosphatidylinositol 4-kinase type 2-beta (EC 2.7.1.67) (Phosphatidylinositol 4-kinase type II-beta) (PI4KII-BETA) | Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell (PubMed:11923287, PubMed:12324459). This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments (PubMed:11923287, PubMed:12324459). The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3) (PubMed:11923287, PubMed:12324459). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking. {ECO:0000269|PubMed:11923287, ECO:0000269|PubMed:12324459}. |
| Q8TCU6 | PREX1 | S1200 | ochoa | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1) (PtdIns(3,4,5)-dependent Rac exchanger 1) | Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils. |
| Q8TDM6 | DLG5 | S1263 | ochoa | Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG) | Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). {ECO:0000250|UniProtKB:E9Q9R9, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:28169360}. |
| Q8WUI4 | HDAC7 | S644 | ochoa | Histone deacetylase 7 (HD7) (EC 3.5.1.98) (Histone deacetylase 7A) (HD7a) (Protein deacetylase HDAC7) (EC 3.5.1.-) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C (By similarity). During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene (PubMed:12239305). Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565). Serves as a corepressor of RARA, causing its deacetylation and inhibition of RARE DNA element binding (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758). Also acetylates non-histone proteins, such as ALKBH5 (PubMed:37369679). {ECO:0000250|UniProtKB:Q8C2B3, ECO:0000269|PubMed:12239305, ECO:0000269|PubMed:17360565, ECO:0000269|PubMed:28167758, ECO:0000269|PubMed:37369679}. |
| Q8WVF1 | OSCP1 | S274 | ochoa | Protein OSCP1 (hOSCP1) (Organic solute transport protein 1) (Oxidored-nitro domain-containing protein 1) | May be involved in drug clearance in the placenta. {ECO:0000269|PubMed:16006562}. |
| Q8WXE0 | CASKIN2 | S825 | ochoa | Caskin-2 (CASK-interacting protein 2) | None |
| Q92614 | MYO18A | S74 | ochoa | Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210) | May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939). {ECO:0000250|UniProtKB:Q9JMH9, ECO:0000269|PubMed:16087679, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:21123169, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:25965346, ECO:0000269|PubMed:27467939}. |
| Q92614 | MYO18A | S987 | ochoa | Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210) | May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939). {ECO:0000250|UniProtKB:Q9JMH9, ECO:0000269|PubMed:16087679, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:21123169, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:25965346, ECO:0000269|PubMed:27467939}. |
| Q92997 | DVL3 | S125 | ochoa|psp | Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) | Involved in the signal transduction pathway mediated by multiple Wnt genes. {ECO:0000250|UniProtKB:Q61062}. |
| Q96BY6 | DOCK10 | S1236 | ochoa | Dedicator of cytokinesis protein 10 (Zizimin-3) | Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression. {ECO:0000250|UniProtKB:Q8BZN6}. |
| Q96F46 | IL17RA | S629 | ochoa|psp | Interleukin-17 receptor A (IL-17 receptor A) (IL-17RA) (CDw217) (CD antigen CD217) | Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Receptor for IL17A (PubMed:17911633, PubMed:9367539). Receptor for IL17F (PubMed:17911633, PubMed:19838198). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (PubMed:16785495). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (PubMed:18684971). Cytokine binding triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways, ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (PubMed:16785495, PubMed:17911633, PubMed:18684971, PubMed:21350122, PubMed:24120361). Involved in antimicrobial host defense primarily promoting neutrophil activation and recruitment at infection sites to destroy extracellular bacteria and fungi (By similarity). In secondary lymphoid organs, contributes to germinal center formation by regulating the chemotactic response of B cells to CXCL12 and CXCL13, enhancing retention of B cells within the germinal centers, B cell somatic hypermutation rate and selection toward plasma cells (By similarity). Plays a role in the maintenance of the integrity of epithelial barriers during homeostasis and pathogen infection. Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (By similarity). Involved in antiviral host defense through various mechanisms. Enhances immunity against West Nile virus by promoting T cell cytotoxicity. Contributes to Influenza virus clearance by driving the differentiation of B-1a B cells, providing for production of virus-specific IgM antibodies at first line of host defense (By similarity). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848). {ECO:0000250|UniProtKB:Q60943, ECO:0000269|PubMed:16785495, ECO:0000269|PubMed:17911633, ECO:0000269|PubMed:18684971, ECO:0000269|PubMed:19838198, ECO:0000269|PubMed:21350122, ECO:0000269|PubMed:21993848, ECO:0000269|PubMed:24120361, ECO:0000269|PubMed:9367539}.; FUNCTION: (Microbial infection) Receptor for SARS coronavirus-2/SARS-CoV-2 virus protein ORF8, leading to IL17 pathway activation and an increased secretion of pro-inflammatory factors through activating NF-kappa-B signaling pathway. {ECO:0000269|PubMed:33723527}. |
| Q96QF0 | RAB3IP | S296 | ochoa | Rab-3A-interacting protein (Rab3A-interacting protein) (Rabin-3) (Rabin8) (SSX2-interacting protein) | Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B (PubMed:12221131, PubMed:26824392). Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (PubMed:12221131, PubMed:26824392). Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5 (PubMed:20937701, PubMed:26824392). Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface (PubMed:12221131). Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (PubMed:20890297). Part of the ciliary targeting complex containing Rab11, ASAP1, RAB3IP and RAB11FIP3 and ARF4 that promotes RAB3IP preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:25673879, PubMed:31204173). {ECO:0000269|PubMed:12221131, ECO:0000269|PubMed:20890297, ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:25673879, ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:31204173}. |
| Q96RT1 | ERBIN | S1179 | ochoa | Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2) | Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). {ECO:0000269|PubMed:10878805, ECO:0000269|PubMed:16203728}. |
| Q99569 | PKP4 | S438 | ochoa | Plakophilin-4 (p0071) | Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269|PubMed:17115030}. |
| Q99575 | POP1 | S584 | ochoa | Ribonucleases P/MRP protein subunit POP1 (hPOP1) | Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:30454648, PubMed:8918471). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465). {ECO:0000269|PubMed:28115465, ECO:0000269|PubMed:30454648, ECO:0000269|PubMed:8918471}. |
| Q99698 | LYST | S2152 | ochoa | Lysosomal-trafficking regulator (Beige homolog) | Adapter protein that regulates and/or fission of intracellular vesicles such as lysosomes (PubMed:11984006, PubMed:25216107). Might regulate trafficking of effectors involved in exocytosis (PubMed:25425525). In cytotoxic T-cells and natural killer (NK) cells, has role in the regulation of size, number and exocytosis of lytic granules (PubMed:26478006). In macrophages and dendritic cells, regulates phagosome maturation by controlling the conversion of early phagosomal compartments into late phagosomes (By similarity). In macrophages and dendritic cells, specifically involved in TLR3- and TLR4-induced production of pro-inflammatory cytokines by regulating the endosomal TLR3- TICAM1/TRIF and TLR4- TICAM1/TRIF signaling pathways (PubMed:27881733). {ECO:0000250|UniProtKB:P97412, ECO:0000269|PubMed:11984006, ECO:0000269|PubMed:25216107, ECO:0000269|PubMed:25425525, ECO:0000269|PubMed:26478006, ECO:0000269|PubMed:27881733}. |
| Q99816 | TSG101 | S48 | ochoa | Tumor susceptibility gene 101 protein (ESCRT-I complex subunit TSG101) | Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). It may also play a role in the extracellular release of microvesicles that differ from the exosomes (PubMed:22315426). {ECO:0000269|PubMed:11916981, ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:21070952, ECO:0000269|PubMed:21757351, ECO:0000269|PubMed:22315426, ECO:0000269|PubMed:22660413}. |
| Q9BTE3 | MCMBP | S193 | ochoa | Mini-chromosome maintenance complex-binding protein (MCM-BP) (MCM-binding protein) | Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion. {ECO:0000269|PubMed:20090939, ECO:0000269|PubMed:21196493}. |
| Q9BX40 | LSM14B | S165 | ochoa | Protein LSM14 homolog B (RNA-associated protein 55B) (hRAP55B) | mRNA-binding protein essential for female fertility, oocyte meiotic maturation and the assembly of MARDO (mitochondria-associated ribonucleoprotein domain), a membraneless compartment that stores maternal mRNAs in oocytes. Ensures the proper accumulation and clearance of mRNAs essential for oocyte meiotic maturation and the normal progression from Meiosis I to Meiosis II in oocytes. Promotes the translation of some oogenesis-related mRNAs. Regulates the expression and/or localization of some key P-body proteins in oocytes. Essential for the assembly of the primordial follicle in the ovary. {ECO:0000250|UniProtKB:Q8CGC4}. |
| Q9BYB0 | SHANK3 | S555 | ochoa | SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) | Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. {ECO:0000269|PubMed:24132240}. |
| Q9BZF2 | OSBPL7 | S272 | ochoa | Oxysterol-binding protein-related protein 7 (ORP-7) (OSBP-related protein 7) | None |
| Q9BZL4 | PPP1R12C | S427 | ochoa | Protein phosphatase 1 regulatory subunit 12C (Protein phosphatase 1 myosin-binding subunit of 85 kDa) (Protein phosphatase 1 myosin-binding subunit p85) | Regulates myosin phosphatase activity. {ECO:0000269|PubMed:11399775}. |
| Q9C0C2 | TNKS1BP1 | S456 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9C0C2 | TNKS1BP1 | S724 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9C0C2 | TNKS1BP1 | S966 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9GZU1 | MCOLN1 | S559 | ochoa|psp | Mucolipin-1 (ML1) (MG-2) (Mucolipidin) (Transient receptor potential channel mucolipin 1) (TRPML1) | Nonselective cation channel probably playing a role in the regulation of membrane trafficking events and of metal homeostasis (PubMed:11013137, PubMed:12459486, PubMed:14749347, PubMed:15336987, PubMed:18794901, PubMed:25720963, PubMed:27623384, PubMed:29019983). Acts as a Ca(2+)-permeable cation channel with inwardly rectifying activity (PubMed:25720963, PubMed:29019983). Proposed to play a major role in Ca(2+) release from late endosome and lysosome vesicles to the cytoplasm, which is important for many lysosome-dependent cellular events, including the fusion and trafficking of these organelles, exocytosis and autophagy (PubMed:11013137, PubMed:12459486, PubMed:14749347, PubMed:15336987, PubMed:25720963, PubMed:27623384, PubMed:29019983). Required for efficient uptake of large particles in macrophages in which Ca(2+) release from the lysosomes triggers lysosomal exocytosis. May also play a role in phagosome-lysosome fusion (By similarity). Involved in lactosylceramide trafficking indicative for a role in the regulation of late endocytic membrane fusion/fission events (PubMed:16978393). By mediating lysosomal Ca(2+) release is involved in regulation of mTORC1 signaling and in mTOR/TFEB-dependent lysosomal adaptation to environmental cues such as nutrient levels (PubMed:25720963, PubMed:25733853, PubMed:27787197). Seems to act as lysosomal active oxygen species (ROS) sensor involved in ROS-induced TFEB activation and autophagy (PubMed:27357649). Also functions as a Fe(2+) permeable channel in late endosomes and lysosomes (PubMed:18794901). Also permeable to Mg(2+), Na(+). K(+) and Cs(+) (By similarity). Proposed to play a role in zinc homeostasis probably implicating its association with TMEM163 (PubMed:25130899) In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells (By similarity). {ECO:0000250|UniProtKB:Q99J21, ECO:0000269|PubMed:12459486, ECO:0000269|PubMed:14749347, ECO:0000269|PubMed:15336987, ECO:0000269|PubMed:16978393, ECO:0000269|PubMed:18794901, ECO:0000269|PubMed:25130899, ECO:0000269|PubMed:25720963, ECO:0000269|PubMed:25733853, ECO:0000269|PubMed:27357649, ECO:0000269|PubMed:27623384, ECO:0000269|PubMed:27787197, ECO:0000269|PubMed:29019983, ECO:0000305|PubMed:11013137}.; FUNCTION: May contribute to cellular lipase activity within the late endosomal pathway or at the cell surface which may be involved in processes of membrane reshaping and vesiculation, especially the growth of tubular structures. However, it is not known, whether it conveys the enzymatic activity directly, or merely facilitates the activity of an associated phospholipase. {ECO:0000305|PubMed:21256127}. |
| Q9H2E6 | SEMA6A | S265 | ochoa | Semaphorin-6A (Semaphorin VIA) (Sema VIA) (Semaphorin-6A-1) (SEMA6A-1) | Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation. {ECO:0000250|UniProtKB:O35464}.; FUNCTION: (Microbial infection) Acts as a receptor for P.sordellii toxin TcsL in the in the vascular endothelium. {ECO:0000269|PubMed:32302524, ECO:0000269|PubMed:32589945}. |
| Q9H5I5 | PIEZO2 | S838 | ochoa | Piezo-type mechanosensitive ion channel component 2 (Protein FAM38B) | Pore-forming subunit of the mechanosensitive non-specific cation Piezo channel required for rapidly adapting mechanically activated (MA) currents and has a key role in sensing touch and tactile pain (PubMed:37590348). Piezo channels are homotrimeric three-blade propeller-shaped structures that utilize a cap-motion and plug-and-latch mechanism to gate their ion-conducting pathways (PubMed:37590348). Expressed in sensory neurons, is essential for diverse physiological processes, including respiratory control, systemic metabolism, urinary function, and proprioception (By similarity). Mediates airway stretch sensing, enabling efficient respiration at birth and maintaining normal breathing in adults (By similarity). It regulates brown and beige adipose tissue morphology and function, preventing systemic hypermetabolism (By similarity). In the lower urinary tract, acts as a sensor in both the bladder urothelium and innervating sensory neurons being required for bladder-stretch sensing and urethral micturition reflexes, ensuring proper urinary function (PubMed:33057202). Additionally, PIEZO2 serves as the principal mechanotransducer in proprioceptors, facilitating proprioception and coordinated body movements (By similarity). In inner ear hair cells, PIEZO1/2 subunits may constitute part of the mechanotransducer (MET) non-selective cation channel complex where they may act as pore-forming ion-conducting component in the complex (By similarity). Required for Merkel-cell mechanotransduction (By similarity). Plays a major role in light-touch mechanosensation (By similarity). {ECO:0000250|UniProtKB:Q8CD54, ECO:0000269|PubMed:33057202, ECO:0000269|PubMed:37590348}. |
| Q9H694 | BICC1 | S31 | ochoa | Protein bicaudal C homolog 1 (Bic-C) | Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development. {ECO:0000269|PubMed:21922595}. |
| Q9HBA0 | TRPV4 | S162 | psp | Transient receptor potential cation channel subfamily V member 4 (TrpV4) (Osm-9-like TRP channel 4) (OTRPC4) (Transient receptor potential protein 12) (TRP12) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC) | Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity (PubMed:16293632, PubMed:18695040, PubMed:18826956, PubMed:22526352, PubMed:23136043, PubMed:29899501). Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification (PubMed:18695040, PubMed:18826956, PubMed:29899501). Also activated by heat, low pH, citrate and phorbol esters (PubMed:16293632, PubMed:18695040, PubMed:18826956, PubMed:20037586, PubMed:21964574, PubMed:25256292). Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism (PubMed:12724311, PubMed:18826956). Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers (By similarity). Acts as a regulator of intracellular Ca(2+) in synoviocytes (PubMed:19759329). Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8 (PubMed:19759329). Together with PKD2, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). Negatively regulates expression of PPARGC1A, UCP1, oxidative metabolism and respiration in adipocytes (By similarity). Regulates expression of chemokines and cytokines related to pro-inflammatory pathway in adipocytes (By similarity). Together with AQP5, controls regulatory volume decrease in salivary epithelial cells (By similarity). Required for normal development and maintenance of bone and cartilage (PubMed:26249260). In its inactive state, may sequester DDX3X at the plasma membrane. When activated, the interaction between both proteins is affected and DDX3X relocalizes to the nucleus (PubMed:29899501). In neurons of the central nervous system, could play a role in triggering voluntary water intake in response to increased sodium concentration in body fluid (By similarity). {ECO:0000250|UniProtKB:Q9EPK8, ECO:0000269|PubMed:11025659, ECO:0000269|PubMed:12724311, ECO:0000269|PubMed:16293632, ECO:0000269|PubMed:18587396, ECO:0000269|PubMed:18695040, ECO:0000269|PubMed:18826956, ECO:0000269|PubMed:19759329, ECO:0000269|PubMed:20037586, ECO:0000269|PubMed:21964574, ECO:0000269|PubMed:23136043, ECO:0000269|PubMed:25256292, ECO:0000269|PubMed:26249260, ECO:0000269|PubMed:29899501}.; FUNCTION: [Isoform 1]: Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by phorbol esters. Has the same channel activity as isoform 1, and is activated by the same stimuli. {ECO:0000269|PubMed:16293632}.; FUNCTION: [Isoform 5]: Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by phorbol esters. Has the same channel activity as isoform 1, and is activated by the same stimuli. {ECO:0000269|PubMed:16293632}.; FUNCTION: [Isoform 2]: Lacks channel activity, due to impaired oligomerization and intracellular retention. {ECO:0000269|PubMed:16293632}.; FUNCTION: [Isoform 4]: Lacks channel activity, due to impaired oligomerization and intracellular retention. {ECO:0000269|PubMed:16293632}.; FUNCTION: [Isoform 6]: Lacks channel activity, due to impaired oligomerization and intracellular retention. {ECO:0000269|PubMed:16293632}.; FUNCTION: (Microbial infection) Facilitates hepatitis C virus (HCV) replication, possibly through its action on DDX3X. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Dengue virus (DENV) replication, possibly through its action on DDX3X. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Zika virus (ZIKV) replication, possibly through its action on DDX3X. {ECO:0000269|PubMed:29899501}. |
| Q9HBE5 | IL21R | S299 | ochoa | Interleukin-21 receptor (IL-21 receptor) (IL-21R) (Novel interleukin receptor) (CD antigen CD360) | This is a receptor for interleukin-21. |
| Q9HCS5 | EPB41L4A | S649 | ochoa | Band 4.1-like protein 4A (Erythrocyte membrane protein band 4.1-like 4A) (Protein NBL4) | None |
| Q9NQQ7 | SLC35C2 | S335 | ochoa | Solute carrier family 35 member C2 (Ovarian cancer-overexpressed gene 1 protein) | May play an important role in the cellular response to tissue hypoxia. May be either a GDP-fucose transporter that competes with SLC35C1 for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells. {ECO:0000269|PubMed:20837470}. |
| Q9NQT8 | KIF13B | S1391 | ochoa | Kinesin-like protein KIF13B (Kinesin-like protein GAKIN) | Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes. {ECO:0000269|PubMed:20194617}. |
| Q9NQT8 | KIF13B | S1797 | ochoa | Kinesin-like protein KIF13B (Kinesin-like protein GAKIN) | Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes. {ECO:0000269|PubMed:20194617}. |
| Q9NRR6 | INPP5E | S99 | ochoa | Phosphatidylinositol polyphosphate 5-phosphatase type IV (72 kDa inositol polyphosphate 5-phosphatase) (Inositol polyphosphate-5-phosphatase E) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase) (EC 3.1.3.86) | Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (By similarity) (PubMed:10764818). Specific for lipid substrates, inactive towards water soluble inositol phosphates (PubMed:10764818). Plays an essential role in the primary cilium by controlling ciliary growth and phosphoinositide 3-kinase (PI3K) signaling and stability (By similarity). {ECO:0000250|UniProtKB:Q9JII1, ECO:0000269|PubMed:10764818}. |
| Q9NS61 | KCNIP2 | S19 | ochoa | A-type potassium channel modulatory protein KCNIP2 (Cardiac voltage-gated potassium channel modulatory subunit) (Kv channel-interacting protein 2) (KChIP2) (Potassium channel-interacting protein 2) | Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels (PubMed:10676964, PubMed:11287421, PubMed:11684073, PubMed:12297301, PubMed:14623880, PubMed:34997220). Modulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner (PubMed:10676964, PubMed:11287421, PubMed:11684073, PubMed:12297301, PubMed:14623880, PubMed:34997220). Involved in KCND2 and KCND3 trafficking to the cell surface (PubMed:12829703). May be required for the expression of I(To) currents in the heart (By similarity). {ECO:0000250|UniProtKB:Q9JJ69, ECO:0000269|PubMed:10676964, ECO:0000269|PubMed:11287421, ECO:0000269|PubMed:11684073, ECO:0000269|PubMed:12297301, ECO:0000269|PubMed:12829703, ECO:0000269|PubMed:14623880, ECO:0000269|PubMed:34997220}. |
| Q9NSA2 | KCND1 | S555 | psp | A-type voltage-gated potassium channel KCND1 (Potassium voltage-gated channel subfamily D member 1) (Shal-type potassium channel KCND1) (Voltage-gated potassium channel subunit Kv4.1) | A-type voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes in the brain (PubMed:15454437). Mediates A-type current I(SA) in suprachiasmatic nucleus (SCN) neurons. Exhibits a low-threshold A-type current with a hyperpolarized steady-state inactivation midpoint and the recovery process was steeply voltage-dependent, with recovery being markedly faster at more negative potentials. May regulates repetitive firing rates in the suprachiasmatic nucleus (SCN) neurons and circadian rhythms in neuronal excitability and behavior. Contributes to the regulation of the circadian rhythm of action potential firing in suprachiasmatic nucleus neurons, which regulates the circadian rhythm of locomotor activity. The regulatory subunit KCNIP1 modulates the kinetics of channel inactivation, increases the current amplitudes and accelerates recovery from inactivation, shifts activation in a depolarizing direction (By similarity). The regulatory subunit DPP10 decreases the voltage sensitivity of the inactivation channel gating (PubMed:15454437). {ECO:0000250|UniProtKB:Q03719, ECO:0000269|PubMed:15454437}. |
| Q9NUL7 | DDX28 | S127 | ochoa | Probable ATP-dependent RNA helicase DDX28 (EC 3.6.4.13) (Mitochondrial DEAD box protein 28) | Plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function (PubMed:25683708, PubMed:25683715). May be involved in RNA processing or transport. Has RNA and Mg(2+)-dependent ATPase activity (PubMed:11350955). {ECO:0000269|PubMed:11350955, ECO:0000269|PubMed:25683708, ECO:0000269|PubMed:25683715}. |
| Q9NUW8 | TDP1 | S81 | psp | Tyrosyl-DNA phosphodiesterase 1 (Tyr-DNA phosphodiesterase 1) (EC 3.1.4.-) | DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate. {ECO:0000269|PubMed:12023295, ECO:0000269|PubMed:15111055, ECO:0000269|PubMed:15811850, ECO:0000269|PubMed:16141202, ECO:0000269|PubMed:22822062}. |
| Q9NUW8 | TDP1 | S365 | psp | Tyrosyl-DNA phosphodiesterase 1 (Tyr-DNA phosphodiesterase 1) (EC 3.1.4.-) | DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate. {ECO:0000269|PubMed:12023295, ECO:0000269|PubMed:15111055, ECO:0000269|PubMed:15811850, ECO:0000269|PubMed:16141202, ECO:0000269|PubMed:22822062}. |
| Q9NX94 | WBP1L | S199 | ochoa | WW domain binding protein 1-like (Outcome predictor in acute leukemia 1) | None |
| Q9NY61 | AATF | S55 | ochoa | Protein AATF (Apoptosis-antagonizing transcription factor) (Rb-binding protein Che-1) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date. {ECO:0000269|PubMed:12450794, ECO:0000269|PubMed:12847090, ECO:0000269|PubMed:14627703, ECO:0000269|PubMed:15207272, ECO:0000269|PubMed:34516797}. |
| Q9NYA4 | MTMR4 | S610 | ochoa | Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4 (EC 3.1.3.95) (FYVE domain-containing dual specificity protein phosphatase 2) (FYVE-DSP2) (Myotubularin-related protein 4) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (Zinc finger FYVE domain-containing protein 11) | Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate (PubMed:11302699, PubMed:16787938, PubMed:20736309, PubMed:27625994, PubMed:29962048, PubMed:30944173). Decreases the levels of phosphatidylinositol 3-phosphate, a phospholipid found in cell membranes where it acts as key regulator of both cell signaling and intracellular membrane traffic, in a subset of endosomal membranes to negatively regulate both endocytic recycling and trafficking and/or maturation of endosomes toward lysosomes (PubMed:16787938, PubMed:20736309, PubMed:29962048). Through phosphatidylinositol 3-phosphate turnover in phagosome membranes regulates phagocytosis and phagosome maturation (PubMed:31543504). By decreasing phosphatidylinositol 3-monophosphate (PI3P) levels in immune cells it can also regulate the innate immune response (PubMed:30944173). Beside its lipid phosphatase activity, can also function as a molecular adapter to regulate midbody abscission during mitotic cytokinesis (PubMed:25659891). Can also negatively regulate TGF-beta and BMP signaling through Smad proteins dephosphorylation and retention in endosomes (PubMed:20061380, PubMed:23150675). {ECO:0000269|PubMed:11302699, ECO:0000269|PubMed:16787938, ECO:0000269|PubMed:20061380, ECO:0000269|PubMed:20736309, ECO:0000269|PubMed:23150675, ECO:0000269|PubMed:25659891, ECO:0000269|PubMed:27625994, ECO:0000269|PubMed:29962048, ECO:0000269|PubMed:30944173, ECO:0000269|PubMed:31543504}. |
| Q9NYD6 | HOXC10 | S60 | ochoa | Homeobox protein Hox-C10 (Homeobox protein Hox-3I) | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. |
| Q9NZ53 | PODXL2 | S582 | ochoa | Podocalyxin-like protein 2 (Endoglycan) | Acts as a ligand for vascular selectins. Mediates rapid rolling of leukocytes over vascular surfaces through high affinity divalent cation-dependent interactions with E-, P- and L-selectins. {ECO:0000269|PubMed:18606703}. |
| Q9NZV8 | KCND2 | S552 | psp | A-type voltage-gated potassium channel KCND2 (Potassium voltage-gated channel subfamily D member 2) (Voltage-gated potassium channel subunit Kv4.2) | Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Mediates the major part of the dendritic A-type current I(SA) in brain neurons (By similarity). This current is activated at membrane potentials that are below the threshold for action potentials. It regulates neuronal excitability, prolongs the latency before the first spike in a series of action potentials, regulates the frequency of repetitive action potential firing, shortens the duration of action potentials and regulates the back-propagation of action potentials from the neuronal cell body to the dendrites. Contributes to the regulation of the circadian rhythm of action potential firing in suprachiasmatic nucleus neurons, which regulates the circadian rhythm of locomotor activity (By similarity). Functions downstream of the metabotropic glutamate receptor GRM5 and plays a role in neuronal excitability and in nociception mediated by activation of GRM5 (By similarity). Mediates the transient outward current I(to) in rodent heart left ventricle apex cells, but not in human heart, where this current is mediated by another family member. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient (PubMed:10551270, PubMed:11507158, PubMed:14623880, PubMed:14695263, PubMed:14980201, PubMed:15454437, PubMed:16934482, PubMed:19171772, PubMed:24501278, PubMed:24811166, PubMed:34552243, PubMed:35597238). The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:11507158). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCND2 and KCND3; channel properties depend on the type of pore-forming alpha subunits that are part of the channel. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes. Interaction with specific isoforms of the regulatory subunits KCNIP1, KCNIP2, KCNIP3 or KCNIP4 strongly increases expression at the cell surface and thereby increases channel activity; it modulates the kinetics of channel activation and inactivation, shifts the threshold for channel activation to more negative voltage values, shifts the threshold for inactivation to less negative voltages and accelerates recovery after inactivation (PubMed:14623880, PubMed:14980201, PubMed:15454437, PubMed:19171772, PubMed:24501278, PubMed:24811166). Likewise, interaction with DPP6 or DPP10 promotes expression at the cell membrane and regulates both channel characteristics and activity (By similarity). Upon depolarization, the channel goes from a resting closed state (C state) to an activated but non-conducting state (C* state), from there, the channel may either inactivate (I state) or open (O state) (PubMed:35597238). {ECO:0000250|UniProtKB:Q63881, ECO:0000250|UniProtKB:Q9Z0V2, ECO:0000269|PubMed:10551270, ECO:0000269|PubMed:10729221, ECO:0000269|PubMed:11507158, ECO:0000269|PubMed:14623880, ECO:0000269|PubMed:14695263, ECO:0000269|PubMed:14980201, ECO:0000269|PubMed:15454437, ECO:0000269|PubMed:16934482, ECO:0000269|PubMed:19171772, ECO:0000269|PubMed:24501278, ECO:0000269|PubMed:24811166, ECO:0000269|PubMed:34552243, ECO:0000269|PubMed:35597238}. |
| Q9P241 | ATP10D | S520 | ochoa | Phospholipid-transporting ATPase VD (EC 7.6.2.1) (ATPase class V type 10D) (P4-ATPase flippase complex alpha subunit ATP10D) | Catalytic component of a P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of glucosylceramide (GlcCer) from the outer to the inner leaflet of the plasma membrane. {ECO:0000269|PubMed:30530492}. |
| Q9P266 | JCAD | S628 | ochoa | Junctional cadherin 5-associated protein (Junctional protein associated with coronary artery disease) (JCAD) | None |
| Q9P275 | USP36 | S825 | ochoa | Ubiquitin carboxyl-terminal hydrolase 36 (EC 2.3.2.-) (EC 3.4.19.12) (Deubiquitinating enzyme 36) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36) | Deubiquitinase essential for the regulation of nucleolar structure and function (PubMed:19208757, PubMed:22902402, PubMed:29273634). Required for cell and organism viability (PubMed:19208757, PubMed:22902402, PubMed:29273634). Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability (PubMed:19208757, PubMed:22902402, PubMed:29273634, PubMed:36912080). Functions as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (PubMed:29274341). Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex (PubMed:25775507). In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm (PubMed:25775507). Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions (PubMed:27445338). Deubiquitinates SOD2, regulates SOD2 protein stability (PubMed:21268071). Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins (PubMed:22622177). Promotes CEP63 stabilization through 'Lys-48'-linked deubiquitination leading to increased stability (PubMed:35989368). Acts as a SUMO ligase to promote EXOSC10 sumoylation critical for the nucleolar RNA exosome function in rRNA processing (PubMed:36912080). Binds to pre-rRNAs (PubMed:36912080). {ECO:0000269|PubMed:19208757, ECO:0000269|PubMed:21268071, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:22902402, ECO:0000269|PubMed:25775507, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:29273634, ECO:0000269|PubMed:29274341, ECO:0000269|PubMed:35989368, ECO:0000269|PubMed:36912080}. |
| Q9P2D0 | IBTK | S1039 | ochoa | Inhibitor of Bruton tyrosine kinase (IBtk) | Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription. {ECO:0000269|PubMed:11577348}. |
| Q9P2F8 | SIPA1L2 | S383 | ochoa | Signal-induced proliferation-associated 1-like protein 2 (SIPA1-like protein 2) | None |
| Q9P2N6 | KANSL3 | S559 | ochoa | KAT8 regulatory NSL complex subunit 3 (NSL complex protein NSL3) (Non-specific lethal 3 homolog) (Serum inhibited-related protein) (Testis development protein PRTD) | Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (PubMed:20018852, PubMed:33657400). The NSL complex also acts as a regulator of gene expression in mitochondria (PubMed:27768893). Within the NSL complex, KANSL3 is required to promote KAT8 association with mitochondrial DNA (PubMed:27768893). Required for transcription of intraciliary transport genes in both ciliated and non-ciliated cells (By similarity). This is necessary for cilium assembly in ciliated cells and for organization of the microtubule cytoskeleton in non-ciliated cells (By similarity). Also required within the NSL complex to maintain nuclear architecture stability by promoting KAT8-mediated acetylation of lamin LMNA (By similarity). Plays an essential role in spindle assembly during mitosis (PubMed:26243146). Acts as a microtubule minus-end binding protein which stabilizes microtubules and promotes their assembly (PubMed:26243146). Indispensable during early embryonic development where it is required for proper lineage specification and maintenance during peri-implantation development and is essential for implantation (By similarity). {ECO:0000250|UniProtKB:A2RSY1, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:26243146, ECO:0000269|PubMed:27768893, ECO:0000269|PubMed:33657400}. |
| Q9P2N7 | KLHL13 | S50 | ochoa | Kelch-like protein 13 (BTB and kelch domain-containing protein 2) | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis. {ECO:0000269|PubMed:14528312, ECO:0000269|PubMed:17543862, ECO:0000269|PubMed:19995937}. |
| Q9UBX3 | SLC25A10 | S93 | ochoa | Mitochondrial dicarboxylate carrier (DIC) (Solute carrier family 25 member 10) | Catalyzes the electroneutral exchange or flux of physiologically important metabolites such as dicarboxylates (malonate, malate, succinate), inorganic sulfur-containing anions, and phosphate, across mitochondrial inner membrane (PubMed:29211846). Plays an important role in gluconeogenesis, fatty acid metabolism, urea synthesis, and sulfur metabolism, particularly in liver, by supplying the substrates for the different metabolic processes. Regulates fatty acid release from adipocytes, and contributes to systemic insulin sensitivity (By similarity). {ECO:0000250|UniProtKB:Q9QZD8, ECO:0000269|PubMed:29211846}. |
| Q9UEW8 | STK39 | S370 | ochoa | STE20/SPS1-related proline-alanine-rich protein kinase (Ste-20-related kinase) (EC 2.7.11.1) (DCHT) (Serine/threonine-protein kinase 39) | Effector serine/threonine-protein kinase component of the WNK-SPAK/OSR1 kinase cascade, which is involved in various processes, such as ion transport, response to hypertonic stress and blood pressure (PubMed:16669787, PubMed:18270262, PubMed:21321328, PubMed:34289367). Specifically recognizes and binds proteins with a RFXV motif (PubMed:16669787, PubMed:21321328). Acts downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4): following activation by WNK kinases, catalyzes phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:21321328). Mediates regulatory volume increase in response to hyperosmotic stress by catalyzing phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1 and SLC12A6/KCC3 downstream of WNK1 and WNK3 kinases (PubMed:12740379, PubMed:16669787, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:16669787, PubMed:19665974, PubMed:21321328). Acts as a regulator of NaCl reabsorption in the distal nephron by mediating phosphorylation and activation of the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney downstream of WNK4 (PubMed:18270262). Mediates the inhibition of SLC4A4, SLC26A6 as well as CFTR activities (By similarity). Phosphorylates RELT (By similarity). {ECO:0000250|UniProtKB:Q9Z1W9, ECO:0000269|PubMed:12740379, ECO:0000269|PubMed:16669787, ECO:0000269|PubMed:18270262, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:34289367}. |
| Q9UHK0 | NUFIP1 | S312 | ochoa | FMR1-interacting protein NUFIP1 (Nuclear FMR1-interacting protein 1) (Nuclear FMRP-interacting protein 1) | Binds RNA. {ECO:0000269|PubMed:10556305}. |
| Q9UK76 | JPT1 | S28 | ochoa | Jupiter microtubule associated homolog 1 (Androgen-regulated protein 2) (Hematological and neurological expressed 1 protein) [Cleaved into: Jupiter microtubule associated homolog 1, N-terminally processed] | Modulates negatively AKT-mediated GSK3B signaling (PubMed:21323578, PubMed:22155408). Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions (PubMed:25169422). Plays a role in the regulation of cell cycle and cell adhesion (PubMed:25169422, PubMed:25450365). Has an inhibitory role on AR-signaling pathway through the induction of receptor proteasomal degradation (PubMed:22155408). {ECO:0000269|PubMed:21323578, ECO:0000269|PubMed:22155408, ECO:0000269|PubMed:25169422, ECO:0000269|PubMed:25450365}. |
| Q9ULC8 | ZDHHC8 | S606 | ochoa | Palmitoyltransferase ZDHHC8 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 8) (DHHC-8) (Zinc finger protein 378) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (Probable). Through the palmitoylation of ABCA1 regulates the localization of the transporter to the plasma membrane and thereby regulates its function in cholesterol and phospholipid efflux (Probable). Could also pamitoylate the D(2) dopamine receptor DRD2 and regulate its stability and localization to the plasma membrane (Probable). Could also play a role in glutamatergic transmission (By similarity). {ECO:0000250|UniProtKB:Q5Y5T5, ECO:0000305|PubMed:19556522, ECO:0000305|PubMed:23034182, ECO:0000305|PubMed:26535572}.; FUNCTION: (Microbial infection) Able to palmitoylate SARS coronavirus-2/SARS-CoV-2 spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment. Once the virus has formed, spike palmitoylation controls fusion with the target cell. {ECO:0000269|PubMed:34599882}. |
| Q9ULD2 | MTUS1 | S279 | ochoa | Microtubule-associated tumor suppressor 1 (AT2 receptor-binding protein) (Angiotensin-II type 2 receptor-interacting protein) (Mitochondrial tumor suppressor 1) | Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. {ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:19794912}. |
| Q9ULI3 | HEG1 | S1319 | ochoa | Protein HEG homolog 1 | Receptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions. {ECO:0000250}. |
| Q9ULJ3 | ZBTB21 | S515 | ochoa | Zinc finger and BTB domain-containing protein 21 (Zinc finger protein 295) | Acts as a transcription repressor. {ECO:0000269|PubMed:15629158}. |
| Q9ULS5 | TMCC3 | S46 | ochoa | Transmembrane and coiled-coil domain protein 3 | None |
| Q9UPA5 | BSN | S2041 | ochoa | Protein bassoon (Zinc finger protein 231) | Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (PubMed:12812759). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (PubMed:19380881). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). Also functions in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy by associating with ATG5 (By similarity). Also mediates synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import (By similarity). Inhibits the activity of the proportion of DAO enzyme that localizes to the presynaptic active zone, which may modulate synaptic transmission (By similarity). {ECO:0000250|UniProtKB:O35078, ECO:0000250|UniProtKB:O88778, ECO:0000269|PubMed:12812759, ECO:0000269|PubMed:19380881}. |
| Q9Y2L6 | FRMD4B | S926 | ochoa | FERM domain-containing protein 4B (GRP1-binding protein GRSP1) | Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex. Plays a redundant role with FRMD4A in epithelial polarization. {ECO:0000250|UniProtKB:Q920B0}. |
| Q9Y3L3 | SH3BP1 | S168 | ochoa | SH3 domain-binding protein 1 | GTPase activating protein (GAP) which specifically converts GTP-bound Rho-type GTPases including RAC1 and CDC42 in their inactive GDP-bound form. By specifically inactivating RAC1 at the leading edge of migrating cells, it regulates the spatiotemporal organization of cell protrusions which is important for proper cell migration (PubMed:21658605). Also negatively regulates CDC42 in the process of actin remodeling and the formation of epithelial cell junctions (PubMed:22891260). Through its GAP activity toward RAC1 and/or CDC42 plays a specific role in phagocytosis of large particles. Specifically recruited by a PI3 kinase/PI3K-dependent mechanism to sites of large particles engagement, inactivates RAC1 and/or CDC42 allowing the reorganization of the underlying actin cytoskeleton required for engulfment (PubMed:26465210). It also plays a role in angiogenesis and the process of repulsive guidance as part of a semaphorin-plexin signaling pathway. Following the binding of PLXND1 to extracellular SEMA3E it dissociates from PLXND1 and inactivates RAC1, inducing the intracellular reorganization of the actin cytoskeleton and the collapse of cells (PubMed:24841563). {ECO:0000269|PubMed:21658605, ECO:0000269|PubMed:22891260, ECO:0000269|PubMed:24841563, ECO:0000269|PubMed:26465210}. |
| Q9Y3M8 | STARD13 | S470 | ochoa | StAR-related lipid transfer protein 13 (46H23.2) (Deleted in liver cancer 2 protein) (DLC-2) (Rho GTPase-activating protein) (START domain-containing protein 13) (StARD13) | GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells. {ECO:0000269|PubMed:14697242, ECO:0000269|PubMed:16217026}. |
| Q9Y3P9 | RABGAP1 | S56 | ochoa | Rab GTPase-activating protein 1 (GAP and centrosome-associated protein) (Rab6 GTPase-activating protein GAPCenA) | May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by centrosome. May participate in a RAB6A-mediated pathway involved in the metaphase-anaphase transition. {ECO:0000269|PubMed:10202141, ECO:0000269|PubMed:16395330}. |
| Q9Y3R5 | DOP1B | S1050 | ochoa | Protein DOP1B | May play a role in regulating membrane trafficking of cargo proteins. Together with ATP9A and MON2, regulates SNX3 retromer-mediated endosomal sorting of WLS away from lysosomal degradation. {ECO:0000269|PubMed:30213940}. |
| Q9Y3T6 | R3HCC1 | S236 | ochoa | R3H and coiled-coil domain-containing protein 1 | None |
| Q9Y446 | PKP3 | S305 | ochoa | Plakophilin-3 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:24124604). Required for the localization of DSG2, DSP and PKP2 to mature desmosome junctions (PubMed:20859650). May also play a role in the maintenance of DSG3 protein abundance in keratinocytes (By similarity). Required for the formation of DSP-containing desmosome precursors in the cytoplasm during desmosome assembly (PubMed:25208567). Also regulates the accumulation of CDH1 to mature desmosome junctions, via cAMP-dependent signaling and its interaction with activated RAP1A (PubMed:25208567). Positively regulates the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with FXR1, may also regulate the protein abundance of DSP via the same mechanism (PubMed:25225333). May also regulate the protein abundance of the desmosome component PKP1 (By similarity). Required for the organization of desmosome junctions at intercellular borders between basal keratinocytes of the epidermis, as a result plays a role in maintenance of the dermal barrier and regulation of the dermal inflammatory response (By similarity). Required during epidermal keratinocyte differentiation for cell adherence at tricellular cell-cell contacts, via regulation of the timely formation of adherens junctions and desmosomes in a calcium-dependent manner, and may also play a role in the organization of the intracellular actin fiber belt (By similarity). Acts as a negative regulator of the inflammatory response in hematopoietic cells of the skin and intestine, via modulation of proinflammatory cytokine production (By similarity). Important for epithelial barrier maintenance in the intestine to reduce intestinal permeability, thereby plays a role in protection from intestinal-derived endotoxemia (By similarity). Required for the development of hair follicles, via a role in the regulation of inner root sheaf length, correct alignment and anterior-posterior polarity of hair follicles (By similarity). Promotes proliferation and cell-cycle G1/S phase transition of keratinocytes (By similarity). Promotes E2F1-driven transcription of G1/S phase promoting genes by acting to release E2F1 from its inhibitory interaction with RB1, via sequestering RB1 and CDKN1A to the cytoplasm and thereby increasing CDK4- and CDK6-driven phosphorylation of RB1 (By similarity). May act as a scaffold protein to facilitate MAPK phosphorylation of RPS6KA protein family members and subsequently promote downstream EGFR signaling (By similarity). May play a role in the positive regulation of transcription of Wnt-mediated TCF-responsive target genes (PubMed:34058472). {ECO:0000250|UniProtKB:Q9QY23, ECO:0000269|PubMed:20859650, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:34058472}. |
| Q9Y4R8 | TELO2 | S485 | psp | Telomere length regulation protein TEL2 homolog (Protein clk-2 homolog) (hCLK2) | Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation. {ECO:0000269|PubMed:12670948, ECO:0000269|PubMed:20810650}. |
| Q9Y5P4 | CERT1 | S123 | ochoa | Ceramide transfer protein (hCERT) (Collagen type IV alpha-3-binding protein) (Goodpasture antigen-binding protein) (GPBP) (START domain-containing protein 11) (StARD11) (StAR-related lipid transfer protein 11) | Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner. {ECO:0000269|PubMed:14685229, ECO:0000269|PubMed:17591919, ECO:0000269|PubMed:18184806, ECO:0000269|PubMed:20036255}. |
| O14965 | AURKA | S266 | GPS6|ELM|EPSD|PSP | Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Breast tumor-amplified kinase) (Ipl1- and aurora-related kinase 1) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase Ayk1) (Serine/threonine-protein kinase aurora-A) | Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression (PubMed:11039908, PubMed:12390251, PubMed:17125279, PubMed:17360485, PubMed:18615013, PubMed:26246606). Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis (PubMed:14523000, PubMed:26246606). Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (PubMed:27335426). Required for initial activation of CDK1 at centrosomes (PubMed:13678582, PubMed:15128871). Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2 (PubMed:11551964, PubMed:14702041, PubMed:15128871, PubMed:15147269, PubMed:15987997, PubMed:17604723, PubMed:18056443, PubMed:18615013). Phosphorylates MCRS1 which is required for MCRS1-mediated kinetochore fiber assembly and mitotic progression (PubMed:27192185). Regulates KIF2A tubulin depolymerase activity (PubMed:19351716). Important for microtubule formation and/or stabilization (PubMed:18056443). Required for normal axon formation (PubMed:19812038). Plays a role in microtubule remodeling during neurite extension (PubMed:19668197). Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and destabilizing p53/TP53 (PubMed:14702041). Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity (PubMed:11551964). Inhibits cilia outgrowth (By similarity). Required for cilia disassembly via phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (PubMed:17604723, PubMed:20643351). Regulates protein levels of the anti-apoptosis protein BIRC5 by suppressing the expression of the SCF(FBXL7) E3 ubiquitin-protein ligase substrate adapter FBXL7 through the phosphorylation of the transcription factor FOXP1 (PubMed:28218735). {ECO:0000250|UniProtKB:A0A8I3S724, ECO:0000269|PubMed:11039908, ECO:0000269|PubMed:11551964, ECO:0000269|PubMed:12390251, ECO:0000269|PubMed:13678582, ECO:0000269|PubMed:14523000, ECO:0000269|PubMed:14702041, ECO:0000269|PubMed:15128871, ECO:0000269|PubMed:15147269, ECO:0000269|PubMed:15987997, ECO:0000269|PubMed:17125279, ECO:0000269|PubMed:17360485, ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:18615013, ECO:0000269|PubMed:19351716, ECO:0000269|PubMed:19668197, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:20643351, ECO:0000269|PubMed:26246606, ECO:0000269|PubMed:27192185, ECO:0000269|PubMed:27335426, ECO:0000269|PubMed:28218735}. |
| P07339 | CTSD | S42 | Sugiyama | Cathepsin D (EC 3.4.23.5) [Cleaved into: Cathepsin D light chain; Cathepsin D heavy chain] | Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation (PubMed:27333034). Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. {ECO:0000269|PubMed:27333034}. |
| Q9UBU9 | NXF1 | S223 | Sugiyama | Nuclear RNA export factor 1 (Tip-associated protein) (Tip-associating protein) (mRNA export factor TAP) | Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway) (PubMed:10924507). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex (PubMed:18364396, PubMed:19165146, PubMed:9660949). ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export (PubMed:18364396, PubMed:19165146, PubMed:9660949). Also involved in nuclear export of m6A-containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). {ECO:0000269|PubMed:10924507, ECO:0000269|PubMed:18364396, ECO:0000269|PubMed:19165146, ECO:0000269|PubMed:28984244, ECO:0000269|PubMed:9660949}. |
| P42685 | FRK | S324 | Sugiyama | Tyrosine-protein kinase FRK (EC 2.7.10.2) (FYN-related kinase) (Nuclear tyrosine protein kinase RAK) (Protein-tyrosine kinase 5) | Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor. {ECO:0000269|PubMed:19345329}. |
| P52788 | SMS | S57 | Sugiyama | Spermine synthase (SPMSY) (EC 2.5.1.22) (Spermidine aminopropyltransferase) | Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM). {ECO:0000269|PubMed:18367445, ECO:0000269|PubMed:18550699, ECO:0000269|PubMed:23696453, ECO:0000269|PubMed:23897707}. |
| Q04721 | NOTCH2 | S1621 | Sugiyama | Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)] | Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (PubMed:21378985, PubMed:21378989). Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation (PubMed:29149593). Positively regulates self-renewal of liver cancer cells (PubMed:25985737). {ECO:0000250|UniProtKB:O35516, ECO:0000269|PubMed:21378985, ECO:0000269|PubMed:21378989, ECO:0000269|PubMed:25985737, ECO:0000269|PubMed:29149593}. |
| Q12931 | TRAP1 | S361 | Sugiyama | Heat shock protein 75 kDa, mitochondrial (HSP 75) (Heat shock protein family C member 5) (TNFR-associated protein 1) (Tumor necrosis factor type 1 receptor-associated protein) (TRAP-1) | Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA. {ECO:0000269|PubMed:23525905, ECO:0000269|PubMed:23564345, ECO:0000269|PubMed:23747254}. |
| Q5T4S7 | UBR4 | S1723 | Sugiyama | E3 ubiquitin-protein ligase UBR4 (EC 2.3.2.27) (600 kDa retinoblastoma protein-associated factor) (p600) (N-recognin-4) (Retinoblastoma-associated factor of 600 kDa) (RBAF600) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm (PubMed:25582440, PubMed:29033132, PubMed:34893540, PubMed:37891180, PubMed:38030679, PubMed:38182926, PubMed:38297121). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180, PubMed:38030679). Recognizes both type-1 and type-2 N-degrons, containing positively charged amino acids (Arg, Lys and His) and bulky and hydrophobic amino acids, respectively (PubMed:38030679). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR5, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR4 probably synthesizes mixed chains containing multiple linkages, while UBR5 is likely branching multiple 'Lys-48'-linked chains of substrates initially modified (PubMed:29033132). Together with KCMF1, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). Mediates ubiquitination of ACLY, leading to its subsequent degradation (PubMed:23932781). Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization (PubMed:16214886). {ECO:0000269|PubMed:16214886, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:25582440, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:37891180, ECO:0000269|PubMed:38030679, ECO:0000269|PubMed:38182926, ECO:0000269|PubMed:38297121}. |
| Q6EMK4 | VASN | S487 | Sugiyama | Vasorin (Protein slit-like 2) | May act as an inhibitor of TGF-beta signaling. {ECO:0000269|PubMed:15247411}. |
| Q6FI81 | CIAPIN1 | S170 | Sugiyama | Anamorsin (Cytokine-induced apoptosis inhibitor 1) (Fe-S cluster assembly protein DRE2 homolog) | Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1 (PubMed:23596212). NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit (By similarity). Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells (By similarity). {ECO:0000250|UniProtKB:P36152, ECO:0000250|UniProtKB:Q8WTY4, ECO:0000255|HAMAP-Rule:MF_03115, ECO:0000269|PubMed:23596212}. |
| Q8N5S9 | CAMKK1 | S57 | Sugiyama | Calcium/calmodulin-dependent protein kinase kinase 1 (CaM-KK 1) (CaM-kinase kinase 1) (CaMKK 1) (EC 2.7.11.17) (CaM-kinase IV kinase) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-KK alpha) (CaM-kinase kinase alpha) (CaMKK alpha) | Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. {ECO:0000269|PubMed:12935886}. |
| Q96HP0 | DOCK6 | S190 | Sugiyama | Dedicator of cytokinesis protein 6 | Acts as a guanine nucleotide exchange factor (GEF) for CDC42 and RAC1 small GTPases. Through its activation of CDC42 and RAC1, may regulate neurite outgrowth (By similarity). {ECO:0000250, ECO:0000269|PubMed:17196961}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 0.000144 | 3.842 |
| R-HSA-5576894 | Phase 1 - inactivation of fast Na+ channels | 0.000265 | 3.577 |
| R-HSA-162582 | Signal Transduction | 0.000660 | 3.181 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.000931 | 3.031 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.002964 | 2.528 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.003079 | 2.512 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.005333 | 2.273 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.005498 | 2.260 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.005333 | 2.273 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.004755 | 2.323 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.005007 | 2.300 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.008151 | 2.089 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.007964 | 2.099 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.008151 | 2.089 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.009109 | 2.041 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 0.010269 | 1.988 |
| R-HSA-446107 | Type I hemidesmosome assembly | 0.012303 | 1.910 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 0.012303 | 1.910 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 0.012303 | 1.910 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.012395 | 1.907 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.010844 | 1.965 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.009887 | 2.005 |
| R-HSA-3295583 | TRP channels | 0.013015 | 1.886 |
| R-HSA-201688 | WNT mediated activation of DVL | 0.014498 | 1.839 |
| R-HSA-5619088 | Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ... | 0.029732 | 1.527 |
| R-HSA-5624958 | ARL13B-mediated ciliary trafficking of INPP5E | 0.044266 | 1.354 |
| R-HSA-5339700 | Signaling by TCF7L2 mutants | 0.044266 | 1.354 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 0.058583 | 1.232 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 0.058583 | 1.232 |
| R-HSA-8854521 | Interaction between PHLDA1 and AURKA | 0.058583 | 1.232 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 0.058583 | 1.232 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 0.058583 | 1.232 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 0.058583 | 1.232 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 0.058583 | 1.232 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 0.058583 | 1.232 |
| R-HSA-3656535 | TGFBR1 LBD Mutants in Cancer | 0.058583 | 1.232 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 0.058583 | 1.232 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 0.058583 | 1.232 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 0.058583 | 1.232 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 0.058583 | 1.232 |
| R-HSA-3645790 | TGFBR2 Kinase Domain Mutants in Cancer | 0.058583 | 1.232 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 0.072686 | 1.139 |
| R-HSA-3656532 | TGFBR1 KD Mutants in Cancer | 0.086580 | 1.063 |
| R-HSA-1306955 | GRB7 events in ERBB2 signaling | 0.086580 | 1.063 |
| R-HSA-5083630 | Defective LFNG causes SCDO3 | 0.086580 | 1.063 |
| R-HSA-3656534 | Loss of Function of TGFBR1 in Cancer | 0.100265 | 0.999 |
| R-HSA-3304356 | SMAD2/3 Phosphorylation Motif Mutants in Cancer | 0.100265 | 0.999 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 0.113747 | 0.944 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.113747 | 0.944 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 0.140110 | 0.854 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 0.140110 | 0.854 |
| R-HSA-1912399 | Pre-NOTCH Processing in the Endoplasmic Reticulum | 0.140110 | 0.854 |
| R-HSA-211957 | Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 | 0.152997 | 0.815 |
| R-HSA-9020958 | Interleukin-21 signaling | 0.165691 | 0.781 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.021832 | 1.661 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 0.178196 | 0.749 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.023301 | 1.633 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.190515 | 0.720 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.190515 | 0.720 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.190515 | 0.720 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.190515 | 0.720 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.202649 | 0.693 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.033210 | 1.479 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.035043 | 1.455 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 0.214603 | 0.668 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.214603 | 0.668 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.214603 | 0.668 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.214603 | 0.668 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.214603 | 0.668 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.214603 | 0.668 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.103431 | 0.985 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 0.237977 | 0.623 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.026662 | 1.574 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.108222 | 0.966 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.108222 | 0.966 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 0.249403 | 0.603 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.249403 | 0.603 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 0.249403 | 0.603 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.117974 | 0.928 |
| R-HSA-72187 | mRNA 3'-end processing | 0.063413 | 1.198 |
| R-HSA-2142816 | Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) | 0.260658 | 0.584 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.132989 | 0.876 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.143227 | 0.844 |
| R-HSA-1296072 | Voltage gated Potassium channels | 0.143227 | 0.844 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.093491 | 1.029 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.093491 | 1.029 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 0.304023 | 0.517 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.304023 | 0.517 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.099493 | 1.002 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.064305 | 1.192 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.124956 | 0.903 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.196453 | 0.707 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.196453 | 0.707 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.196453 | 0.707 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.196453 | 0.707 |
| R-HSA-380287 | Centrosome maturation | 0.131658 | 0.881 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.170573 | 0.768 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.170573 | 0.768 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.181711 | 0.741 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.262753 | 0.580 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.085644 | 1.067 |
| R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 0.324746 | 0.488 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.163015 | 0.788 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.163015 | 0.788 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.166906 | 0.778 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.169479 | 0.771 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.169479 | 0.771 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.163015 | 0.788 |
| R-HSA-9762292 | Regulation of CDH11 function | 0.178196 | 0.749 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 0.190515 | 0.720 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 0.314462 | 0.502 |
| R-HSA-6798695 | Neutrophil degranulation | 0.297487 | 0.527 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.196453 | 0.707 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 0.024783 | 1.606 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.040662 | 1.391 |
| R-HSA-163615 | PKA activation | 0.047838 | 1.320 |
| R-HSA-5673000 | RAF activation | 0.024822 | 1.605 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.329217 | 0.483 |
| R-HSA-4641265 | Repression of WNT target genes | 0.214603 | 0.668 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.089436 | 1.048 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 0.314462 | 0.502 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.076071 | 1.119 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.220104 | 0.657 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 0.260658 | 0.584 |
| R-HSA-9664420 | Killing mechanisms | 0.260658 | 0.584 |
| R-HSA-2564830 | Cytosolic iron-sulfur cluster assembly | 0.293425 | 0.533 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.100265 | 0.999 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.271745 | 0.566 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.098701 | 1.006 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.273878 | 0.562 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.103431 | 0.985 |
| R-HSA-3304351 | Signaling by TGF-beta Receptor Complex in Cancer | 0.127027 | 0.896 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.103431 | 0.985 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.235903 | 0.627 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.113070 | 0.947 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.103431 | 0.985 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.271745 | 0.566 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.021832 | 1.661 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.120880 | 0.918 |
| R-HSA-3642278 | Loss of Function of TGFBR2 in Cancer | 0.058583 | 1.232 |
| R-HSA-8875513 | MET interacts with TNS proteins | 0.072686 | 1.139 |
| R-HSA-3304349 | Loss of Function of SMAD2/3 in Cancer | 0.113747 | 0.944 |
| R-HSA-164378 | PKA activation in glucagon signalling | 0.047838 | 1.320 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 0.165691 | 0.781 |
| R-HSA-4839744 | Signaling by APC mutants | 0.190515 | 0.720 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.202649 | 0.693 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.202649 | 0.693 |
| R-HSA-525793 | Myogenesis | 0.084907 | 1.071 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 0.214603 | 0.668 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.214603 | 0.668 |
| R-HSA-174490 | Membrane binding and targetting of GAG proteins | 0.226378 | 0.645 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.143227 | 0.844 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.087646 | 1.057 |
| R-HSA-2142670 | Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) | 0.293425 | 0.533 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 0.314462 | 0.502 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.191013 | 0.719 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.067554 | 1.170 |
| R-HSA-170968 | Frs2-mediated activation | 0.226378 | 0.645 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.038862 | 1.410 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.087577 | 1.058 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.089412 | 1.049 |
| R-HSA-111931 | PKA-mediated phosphorylation of CREB | 0.059382 | 1.226 |
| R-HSA-169893 | Prolonged ERK activation events | 0.260658 | 0.584 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.249403 | 0.603 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.180196 | 0.744 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 0.055435 | 1.256 |
| R-HSA-9707616 | Heme signaling | 0.022349 | 1.651 |
| R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 0.237977 | 0.623 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.122930 | 0.910 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 0.282667 | 0.549 |
| R-HSA-5617833 | Cilium Assembly | 0.098879 | 1.005 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.223687 | 0.650 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.207390 | 0.683 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.118383 | 0.927 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.122226 | 0.913 |
| R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 0.113747 | 0.944 |
| R-HSA-187706 | Signalling to p38 via RIT and RIN | 0.113747 | 0.944 |
| R-HSA-442720 | CREB1 phosphorylation through the activation of Adenylate Cyclase | 0.027706 | 1.557 |
| R-HSA-170984 | ARMS-mediated activation | 0.165691 | 0.781 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 0.059382 | 1.226 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 0.076071 | 1.119 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.202649 | 0.693 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 0.271745 | 0.566 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.268315 | 0.571 |
| R-HSA-191859 | snRNP Assembly | 0.268315 | 0.571 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.279438 | 0.554 |
| R-HSA-68877 | Mitotic Prometaphase | 0.103949 | 0.983 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.229437 | 0.639 |
| R-HSA-9610379 | HCMV Late Events | 0.272472 | 0.565 |
| R-HSA-8985947 | Interleukin-9 signaling | 0.152997 | 0.815 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.076445 | 1.117 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 0.152997 | 0.815 |
| R-HSA-2028269 | Signaling by Hippo | 0.282667 | 0.549 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.038862 | 1.410 |
| R-HSA-390650 | Histamine receptors | 0.072686 | 1.139 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.127936 | 0.893 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 0.282667 | 0.549 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 0.282667 | 0.549 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.090548 | 1.043 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.186542 | 0.729 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.189242 | 0.723 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.224034 | 0.650 |
| R-HSA-8983711 | OAS antiviral response | 0.024783 | 1.606 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.293425 | 0.533 |
| R-HSA-162587 | HIV Life Cycle | 0.272472 | 0.565 |
| R-HSA-111933 | Calmodulin induced events | 0.028021 | 1.553 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.074807 | 1.126 |
| R-HSA-425986 | Sodium/Proton exchangers | 0.152997 | 0.815 |
| R-HSA-111997 | CaM pathway | 0.028021 | 1.553 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 0.084907 | 1.071 |
| R-HSA-428643 | Organic anion transport by SLC5/17/25 transporters | 0.293425 | 0.533 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.158877 | 0.799 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.158877 | 0.799 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.164162 | 0.785 |
| R-HSA-157118 | Signaling by NOTCH | 0.045307 | 1.344 |
| R-HSA-8953854 | Metabolism of RNA | 0.224086 | 0.650 |
| R-HSA-9909396 | Circadian clock | 0.025900 | 1.587 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 0.178196 | 0.749 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 0.080451 | 1.094 |
| R-HSA-111996 | Ca-dependent events | 0.040848 | 1.389 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.047108 | 1.327 |
| R-HSA-983189 | Kinesins | 0.084783 | 1.072 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.166906 | 0.778 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.177976 | 0.750 |
| R-HSA-69275 | G2/M Transition | 0.092329 | 1.035 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.282454 | 0.549 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 0.113747 | 0.944 |
| R-HSA-1483148 | Synthesis of PG | 0.040662 | 1.391 |
| R-HSA-1483248 | Synthesis of PIPs at the ER membrane | 0.190515 | 0.720 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.214603 | 0.668 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.214603 | 0.668 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.214603 | 0.668 |
| R-HSA-8949664 | Processing of SMDT1 | 0.226378 | 0.645 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.148407 | 0.829 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.196453 | 0.707 |
| R-HSA-9634597 | GPER1 signaling | 0.207390 | 0.683 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.268315 | 0.571 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.095574 | 1.020 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.276155 | 0.559 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.223687 | 0.650 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.038080 | 1.419 |
| R-HSA-112043 | PLC beta mediated events | 0.087646 | 1.057 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 0.084907 | 1.071 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 0.249403 | 0.603 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.220104 | 0.657 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 0.164162 | 0.785 |
| R-HSA-446728 | Cell junction organization | 0.166749 | 0.778 |
| R-HSA-442380 | Zinc influx into cells by the SLC39 gene family | 0.165691 | 0.781 |
| R-HSA-180024 | DARPP-32 events | 0.098701 | 1.006 |
| R-HSA-9018681 | Biosynthesis of protectins | 0.237977 | 0.623 |
| R-HSA-5578768 | Physiological factors | 0.237977 | 0.623 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 0.122930 | 0.910 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 0.260658 | 0.584 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.271745 | 0.566 |
| R-HSA-1614517 | Sulfide oxidation to sulfate | 0.282667 | 0.549 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.153624 | 0.814 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.293425 | 0.533 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 0.191013 | 0.719 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.066193 | 1.179 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.128291 | 0.892 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.045462 | 1.342 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 0.329217 | 0.483 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.207390 | 0.683 |
| R-HSA-68886 | M Phase | 0.265661 | 0.576 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 0.019350 | 1.713 |
| R-HSA-9823730 | Formation of definitive endoderm | 0.314462 | 0.502 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.158877 | 0.799 |
| R-HSA-1500931 | Cell-Cell communication | 0.246709 | 0.608 |
| R-HSA-9833110 | RSV-host interactions | 0.100182 | 0.999 |
| R-HSA-112040 | G-protein mediated events | 0.105646 | 0.976 |
| R-HSA-9010642 | ROBO receptors bind AKAP5 | 0.152997 | 0.815 |
| R-HSA-9027307 | Biosynthesis of maresin-like SPMs | 0.271745 | 0.566 |
| R-HSA-8854214 | TBC/RABGAPs | 0.180196 | 0.744 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.318216 | 0.497 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.164162 | 0.785 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 0.191013 | 0.719 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.196453 | 0.707 |
| R-HSA-70171 | Glycolysis | 0.088816 | 1.052 |
| R-HSA-1474290 | Collagen formation | 0.208405 | 0.681 |
| R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 0.140110 | 0.854 |
| R-HSA-9839389 | TGFBR3 regulates TGF-beta signaling | 0.140110 | 0.854 |
| R-HSA-8956320 | Nucleotide biosynthesis | 0.234975 | 0.629 |
| R-HSA-5576891 | Cardiac conduction | 0.073591 | 1.133 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.183785 | 0.736 |
| R-HSA-112316 | Neuronal System | 0.207123 | 0.684 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.029119 | 1.536 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.243877 | 0.613 |
| R-HSA-1483255 | PI Metabolism | 0.093284 | 1.030 |
| R-HSA-913531 | Interferon Signaling | 0.160294 | 0.795 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 0.165691 | 0.781 |
| R-HSA-8963896 | HDL assembly | 0.237977 | 0.623 |
| R-HSA-416700 | Other semaphorin interactions | 0.249403 | 0.603 |
| R-HSA-432142 | Platelet sensitization by LDL | 0.293425 | 0.533 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.324746 | 0.488 |
| R-HSA-111885 | Opioid Signalling | 0.251894 | 0.599 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.110090 | 0.958 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.033940 | 1.469 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.152997 | 0.815 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.165691 | 0.781 |
| R-HSA-70326 | Glucose metabolism | 0.049859 | 1.302 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.097857 | 1.009 |
| R-HSA-70268 | Pyruvate metabolism | 0.058814 | 1.231 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.273878 | 0.562 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.272093 | 0.565 |
| R-HSA-1640170 | Cell Cycle | 0.214447 | 0.669 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 0.271745 | 0.566 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.317027 | 0.499 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 0.174824 | 0.757 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.124794 | 0.904 |
| R-HSA-445717 | Aquaporin-mediated transport | 0.279438 | 0.554 |
| R-HSA-435354 | Zinc transporters | 0.237977 | 0.623 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.081962 | 1.086 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.267788 | 0.572 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.201773 | 0.695 |
| R-HSA-397014 | Muscle contraction | 0.274047 | 0.562 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.103431 | 0.985 |
| R-HSA-425410 | Metal ion SLC transporters | 0.207390 | 0.683 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.329217 | 0.483 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.042420 | 1.372 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.128300 | 0.892 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.152482 | 0.817 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.284996 | 0.545 |
| R-HSA-1483166 | Synthesis of PA | 0.257190 | 0.590 |
| R-HSA-1442490 | Collagen degradation | 0.279438 | 0.554 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.056140 | 1.251 |
| R-HSA-163685 | Integration of energy metabolism | 0.201773 | 0.695 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.317027 | 0.499 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.113070 | 0.947 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.084783 | 1.072 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.084783 | 1.072 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.084783 | 1.072 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.084783 | 1.072 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.257190 | 0.590 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.026655 | 1.574 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.204864 | 0.689 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.138087 | 0.860 |
| R-HSA-75153 | Apoptotic execution phase | 0.196453 | 0.707 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.084783 | 1.072 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.135056 | 0.869 |
| R-HSA-73887 | Death Receptor Signaling | 0.120880 | 0.918 |
| R-HSA-68875 | Mitotic Prophase | 0.329331 | 0.482 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.333432 | 0.477 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.334876 | 0.475 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.334876 | 0.475 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.334876 | 0.475 |
| R-HSA-175474 | Assembly Of The HIV Virion | 0.334876 | 0.475 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 0.334876 | 0.475 |
| R-HSA-2022377 | Metabolism of Angiotensinogen to Angiotensins | 0.334876 | 0.475 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.340170 | 0.468 |
| R-HSA-1483257 | Phospholipid metabolism | 0.340437 | 0.468 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.344854 | 0.462 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.345728 | 0.461 |
| R-HSA-195721 | Signaling by WNT | 0.348414 | 0.458 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.351067 | 0.455 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 0.354684 | 0.450 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 0.354684 | 0.450 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 0.354684 | 0.450 |
| R-HSA-9937008 | Mitochondrial mRNA modification | 0.354684 | 0.450 |
| R-HSA-9018682 | Biosynthesis of maresins | 0.354684 | 0.450 |
| R-HSA-3000170 | Syndecan interactions | 0.354684 | 0.450 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.354684 | 0.450 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 0.364366 | 0.438 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.364366 | 0.438 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.364366 | 0.438 |
| R-HSA-429947 | Deadenylation of mRNA | 0.364366 | 0.438 |
| R-HSA-9836573 | Mitochondrial RNA degradation | 0.364366 | 0.438 |
| R-HSA-8963898 | Plasma lipoprotein assembly | 0.364366 | 0.438 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.372669 | 0.429 |
| R-HSA-9839394 | TGFBR3 expression | 0.373904 | 0.427 |
| R-HSA-3000157 | Laminin interactions | 0.373904 | 0.427 |
| R-HSA-9659379 | Sensory processing of sound | 0.378026 | 0.422 |
| R-HSA-9843745 | Adipogenesis | 0.382451 | 0.417 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.383300 | 0.416 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.383300 | 0.416 |
| R-HSA-9833482 | PKR-mediated signaling | 0.383363 | 0.416 |
| R-HSA-983712 | Ion channel transport | 0.384030 | 0.416 |
| R-HSA-9609646 | HCMV Infection | 0.385813 | 0.414 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.392554 | 0.406 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.392554 | 0.406 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.392554 | 0.406 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.399255 | 0.399 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.400965 | 0.397 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.401671 | 0.396 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.401671 | 0.396 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.401671 | 0.396 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.401671 | 0.396 |
| R-HSA-77387 | Insulin receptor recycling | 0.401671 | 0.396 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.401671 | 0.396 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.409551 | 0.388 |
| R-HSA-72086 | mRNA Capping | 0.410651 | 0.387 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 0.410651 | 0.387 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.410651 | 0.387 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.410651 | 0.387 |
| R-HSA-418360 | Platelet calcium homeostasis | 0.410651 | 0.387 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.410651 | 0.387 |
| R-HSA-420092 | Glucagon-type ligand receptors | 0.410651 | 0.387 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.415216 | 0.382 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.415216 | 0.382 |
| R-HSA-8957322 | Metabolism of steroids | 0.417884 | 0.379 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.419497 | 0.377 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.419497 | 0.377 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.420143 | 0.377 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.421178 | 0.376 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 0.428211 | 0.368 |
| R-HSA-162588 | Budding and maturation of HIV virion | 0.428211 | 0.368 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.428211 | 0.368 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.428211 | 0.368 |
| R-HSA-199991 | Membrane Trafficking | 0.429137 | 0.367 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.436795 | 0.360 |
| R-HSA-72172 | mRNA Splicing | 0.437900 | 0.359 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.445250 | 0.351 |
| R-HSA-9930044 | Nuclear RNA decay | 0.445250 | 0.351 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.445250 | 0.351 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.445250 | 0.351 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.450764 | 0.346 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.453579 | 0.343 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 0.453579 | 0.343 |
| R-HSA-1980145 | Signaling by NOTCH2 | 0.461783 | 0.336 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 0.461783 | 0.336 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.461783 | 0.336 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.461783 | 0.336 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.461783 | 0.336 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.469865 | 0.328 |
| R-HSA-187687 | Signalling to ERKs | 0.469865 | 0.328 |
| R-HSA-917977 | Transferrin endocytosis and recycling | 0.469865 | 0.328 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.469865 | 0.328 |
| R-HSA-68882 | Mitotic Anaphase | 0.477426 | 0.321 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.477825 | 0.321 |
| R-HSA-8853659 | RET signaling | 0.477825 | 0.321 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.477825 | 0.321 |
| R-HSA-1296071 | Potassium Channels | 0.480452 | 0.318 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.480674 | 0.318 |
| R-HSA-1989781 | PPARA activates gene expression | 0.485062 | 0.314 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.485667 | 0.314 |
| R-HSA-4641258 | Degradation of DVL | 0.485667 | 0.314 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.485667 | 0.314 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.485667 | 0.314 |
| R-HSA-8948216 | Collagen chain trimerization | 0.485667 | 0.314 |
| R-HSA-422356 | Regulation of insulin secretion | 0.490129 | 0.310 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.492638 | 0.307 |
| R-HSA-8875878 | MET promotes cell motility | 0.493391 | 0.307 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.499692 | 0.301 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.501000 | 0.300 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.501000 | 0.300 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 0.501000 | 0.300 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.501000 | 0.300 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.508495 | 0.294 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.508495 | 0.294 |
| R-HSA-167169 | HIV Transcription Elongation | 0.508495 | 0.294 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.508495 | 0.294 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.509140 | 0.293 |
| R-HSA-162906 | HIV Infection | 0.512701 | 0.290 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.515855 | 0.287 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.515878 | 0.287 |
| R-HSA-5423646 | Aflatoxin activation and detoxification | 0.515878 | 0.287 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.515878 | 0.287 |
| R-HSA-9694548 | Maturation of spike protein | 0.515878 | 0.287 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.515878 | 0.287 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.516603 | 0.287 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.518710 | 0.285 |
| R-HSA-5619102 | SLC transporter disorders | 0.529662 | 0.276 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 0.530314 | 0.275 |
| R-HSA-73928 | Depyrimidination | 0.530314 | 0.275 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 0.530314 | 0.275 |
| R-HSA-418346 | Platelet homeostasis | 0.532246 | 0.274 |
| R-HSA-211000 | Gene Silencing by RNA | 0.536778 | 0.270 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.537371 | 0.270 |
| R-HSA-8939211 | ESR-mediated signaling | 0.543806 | 0.265 |
| R-HSA-72306 | tRNA processing | 0.544048 | 0.264 |
| R-HSA-373752 | Netrin-1 signaling | 0.544322 | 0.264 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.544322 | 0.264 |
| R-HSA-156581 | Methylation | 0.544322 | 0.264 |
| R-HSA-5683826 | Surfactant metabolism | 0.544322 | 0.264 |
| R-HSA-375280 | Amine ligand-binding receptors | 0.544322 | 0.264 |
| R-HSA-418555 | G alpha (s) signalling events | 0.547605 | 0.262 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.551169 | 0.259 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.551169 | 0.259 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.551169 | 0.259 |
| R-HSA-1614558 | Degradation of cysteine and homocysteine | 0.551169 | 0.259 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.554670 | 0.256 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.554670 | 0.256 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 0.557913 | 0.253 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.558982 | 0.253 |
| R-HSA-70263 | Gluconeogenesis | 0.571101 | 0.243 |
| R-HSA-9766229 | Degradation of CDH1 | 0.577547 | 0.238 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 0.580421 | 0.236 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.580421 | 0.236 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.580421 | 0.236 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.588781 | 0.230 |
| R-HSA-156584 | Cytosolic sulfonation of small molecules | 0.590151 | 0.229 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.592914 | 0.227 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.596312 | 0.225 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.596312 | 0.225 |
| R-HSA-5688426 | Deubiquitination | 0.597105 | 0.224 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.602380 | 0.220 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.602380 | 0.220 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.602380 | 0.220 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.602380 | 0.220 |
| R-HSA-3371556 | Cellular response to heat stress | 0.605129 | 0.218 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 0.608358 | 0.216 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.613117 | 0.212 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.613117 | 0.212 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.614247 | 0.212 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.614247 | 0.212 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.614247 | 0.212 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.617065 | 0.210 |
| R-HSA-5578775 | Ion homeostasis | 0.620047 | 0.208 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.620047 | 0.208 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.620047 | 0.208 |
| R-HSA-416476 | G alpha (q) signalling events | 0.622329 | 0.206 |
| R-HSA-194138 | Signaling by VEGF | 0.624868 | 0.204 |
| R-HSA-69206 | G1/S Transition | 0.624868 | 0.204 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.625760 | 0.204 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.628724 | 0.202 |
| R-HSA-9609690 | HCMV Early Events | 0.631007 | 0.200 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.631007 | 0.200 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.631388 | 0.200 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.636858 | 0.196 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.636931 | 0.196 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.642392 | 0.192 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.642392 | 0.192 |
| R-HSA-351202 | Metabolism of polyamines | 0.642392 | 0.192 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.643838 | 0.191 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.651134 | 0.186 |
| R-HSA-1268020 | Mitochondrial protein import | 0.653068 | 0.185 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.654854 | 0.184 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.655813 | 0.183 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.658287 | 0.182 |
| R-HSA-8848021 | Signaling by PTK6 | 0.658287 | 0.182 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.658287 | 0.182 |
| R-HSA-373755 | Semaphorin interactions | 0.658287 | 0.182 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.663428 | 0.178 |
| R-HSA-211981 | Xenobiotics | 0.663428 | 0.178 |
| R-HSA-6805567 | Keratinization | 0.664180 | 0.178 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.672609 | 0.172 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.673479 | 0.172 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.678392 | 0.169 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.679501 | 0.168 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.681344 | 0.167 |
| R-HSA-6807070 | PTEN Regulation | 0.682903 | 0.166 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.682903 | 0.166 |
| R-HSA-167172 | Transcription of the HIV genome | 0.683231 | 0.165 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 0.683231 | 0.165 |
| R-HSA-913709 | O-linked glycosylation of mucins | 0.683231 | 0.165 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.687011 | 0.163 |
| R-HSA-448424 | Interleukin-17 signaling | 0.692693 | 0.159 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.692693 | 0.159 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.692693 | 0.159 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.697318 | 0.157 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 0.697318 | 0.157 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.697318 | 0.157 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.697318 | 0.157 |
| R-HSA-418990 | Adherens junctions interactions | 0.697851 | 0.156 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 0.701873 | 0.154 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.703661 | 0.153 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.706361 | 0.151 |
| R-HSA-4086398 | Ca2+ pathway | 0.706361 | 0.151 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.709067 | 0.149 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.710221 | 0.149 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.710781 | 0.148 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.710781 | 0.148 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.710781 | 0.148 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 0.715135 | 0.146 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.715135 | 0.146 |
| R-HSA-917937 | Iron uptake and transport | 0.715135 | 0.146 |
| R-HSA-5689603 | UCH proteinases | 0.719423 | 0.143 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.723647 | 0.140 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.727491 | 0.138 |
| R-HSA-4086400 | PCP/CE pathway | 0.727808 | 0.138 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.727808 | 0.138 |
| R-HSA-9955298 | SLC-mediated transport of organic anions | 0.727808 | 0.138 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.730465 | 0.136 |
| R-HSA-9609507 | Protein localization | 0.730465 | 0.136 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 0.731907 | 0.136 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.735944 | 0.133 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.735944 | 0.133 |
| R-HSA-6806834 | Signaling by MET | 0.735944 | 0.133 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.736329 | 0.133 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.739920 | 0.131 |
| R-HSA-9018677 | Biosynthesis of DHA-derived SPMs | 0.739920 | 0.131 |
| R-HSA-1280218 | Adaptive Immune System | 0.742174 | 0.129 |
| R-HSA-15869 | Metabolism of nucleotides | 0.743485 | 0.129 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.743508 | 0.129 |
| R-HSA-877300 | Interferon gamma signaling | 0.747732 | 0.126 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.750517 | 0.125 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.755239 | 0.122 |
| R-HSA-109581 | Apoptosis | 0.756006 | 0.121 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.758926 | 0.120 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.762557 | 0.118 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.762557 | 0.118 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 0.762557 | 0.118 |
| R-HSA-388396 | GPCR downstream signalling | 0.763964 | 0.117 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.766135 | 0.116 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.768579 | 0.114 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.775108 | 0.111 |
| R-HSA-73884 | Base Excision Repair | 0.776548 | 0.110 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 0.776548 | 0.110 |
| R-HSA-109582 | Hemostasis | 0.777062 | 0.110 |
| R-HSA-421270 | Cell-cell junction organization | 0.777197 | 0.109 |
| R-HSA-1474244 | Extracellular matrix organization | 0.777317 | 0.109 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.779439 | 0.108 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.779915 | 0.108 |
| R-HSA-391251 | Protein folding | 0.786499 | 0.104 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.786499 | 0.104 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.786499 | 0.104 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.786499 | 0.104 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.786499 | 0.104 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.786802 | 0.104 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.786802 | 0.104 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.786802 | 0.104 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.787598 | 0.104 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.789208 | 0.103 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.789717 | 0.103 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.792886 | 0.101 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.792886 | 0.101 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.796008 | 0.099 |
| R-HSA-168255 | Influenza Infection | 0.800884 | 0.096 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.805096 | 0.094 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.808035 | 0.093 |
| R-HSA-190236 | Signaling by FGFR | 0.808035 | 0.093 |
| R-HSA-3214847 | HATs acetylate histones | 0.810929 | 0.091 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 0.810929 | 0.091 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.820465 | 0.086 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.824763 | 0.084 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.827407 | 0.082 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.827407 | 0.082 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.832575 | 0.080 |
| R-HSA-9658195 | Leishmania infection | 0.833739 | 0.079 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.833739 | 0.079 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.835101 | 0.078 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.835101 | 0.078 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.835101 | 0.078 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.837589 | 0.077 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 0.842453 | 0.074 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.847060 | 0.072 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.849301 | 0.071 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.851751 | 0.070 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.853989 | 0.069 |
| R-HSA-5357801 | Programmed Cell Death | 0.854539 | 0.068 |
| R-HSA-372790 | Signaling by GPCR | 0.857248 | 0.067 |
| R-HSA-5693538 | Homology Directed Repair | 0.864683 | 0.063 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.874597 | 0.058 |
| R-HSA-8951664 | Neddylation | 0.879776 | 0.056 |
| R-HSA-114608 | Platelet degranulation | 0.883787 | 0.054 |
| R-HSA-69481 | G2/M Checkpoints | 0.883787 | 0.054 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.885543 | 0.053 |
| R-HSA-418594 | G alpha (i) signalling events | 0.888527 | 0.051 |
| R-HSA-72312 | rRNA processing | 0.894721 | 0.048 |
| R-HSA-382551 | Transport of small molecules | 0.894839 | 0.048 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.895538 | 0.048 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.897246 | 0.047 |
| R-HSA-5173105 | O-linked glycosylation | 0.903199 | 0.044 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 0.903315 | 0.044 |
| R-HSA-168256 | Immune System | 0.904907 | 0.043 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.912994 | 0.040 |
| R-HSA-9018678 | Biosynthesis of specialized proresolving mediators (SPMs) | 0.912994 | 0.040 |
| R-HSA-4839726 | Chromatin organization | 0.914465 | 0.039 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.918141 | 0.037 |
| R-HSA-166520 | Signaling by NTRKs | 0.919379 | 0.037 |
| R-HSA-9758941 | Gastrulation | 0.920599 | 0.036 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.921801 | 0.035 |
| R-HSA-2142753 | Arachidonate metabolism | 0.924150 | 0.034 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.924150 | 0.034 |
| R-HSA-73894 | DNA Repair | 0.927418 | 0.033 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.928067 | 0.032 |
| R-HSA-9612973 | Autophagy | 0.928640 | 0.032 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.930784 | 0.031 |
| R-HSA-422475 | Axon guidance | 0.930903 | 0.031 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.932411 | 0.030 |
| R-HSA-9824446 | Viral Infection Pathways | 0.933391 | 0.030 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.936876 | 0.028 |
| R-HSA-9679506 | SARS-CoV Infections | 0.937072 | 0.028 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 0.939667 | 0.027 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.941248 | 0.026 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.944949 | 0.025 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.947414 | 0.023 |
| R-HSA-611105 | Respiratory electron transport | 0.949770 | 0.022 |
| R-HSA-556833 | Metabolism of lipids | 0.951288 | 0.022 |
| R-HSA-9675108 | Nervous system development | 0.951345 | 0.022 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.952459 | 0.021 |
| R-HSA-3781865 | Diseases of glycosylation | 0.954170 | 0.020 |
| R-HSA-8978868 | Fatty acid metabolism | 0.957564 | 0.019 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.964116 | 0.016 |
| R-HSA-428157 | Sphingolipid metabolism | 0.964661 | 0.016 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.965197 | 0.015 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.965726 | 0.015 |
| R-HSA-449147 | Signaling by Interleukins | 0.968128 | 0.014 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.971037 | 0.013 |
| R-HSA-1643685 | Disease | 0.977355 | 0.010 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.977678 | 0.010 |
| R-HSA-168249 | Innate Immune System | 0.985623 | 0.006 |
| R-HSA-5663205 | Infectious disease | 0.988556 | 0.005 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.988639 | 0.005 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.989317 | 0.005 |
| R-HSA-2262752 | Cellular responses to stress | 0.989832 | 0.004 |
| R-HSA-74160 | Gene expression (Transcription) | 0.991120 | 0.004 |
| R-HSA-597592 | Post-translational protein modification | 0.992351 | 0.003 |
| R-HSA-1266738 | Developmental Biology | 0.997155 | 0.001 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.997163 | 0.001 |
| R-HSA-211859 | Biological oxidations | 0.997757 | 0.001 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.998132 | 0.001 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.998244 | 0.001 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.998778 | 0.001 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.998862 | 0.000 |
| R-HSA-5668914 | Diseases of metabolism | 0.998947 | 0.000 |
| R-HSA-72766 | Translation | 0.998979 | 0.000 |
| R-HSA-392499 | Metabolism of proteins | 0.999019 | 0.000 |
| R-HSA-500792 | GPCR ligand binding | 0.999112 | 0.000 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.999411 | 0.000 |
| R-HSA-212436 | Generic Transcription Pathway | 0.999694 | 0.000 |
| R-HSA-1430728 | Metabolism | 0.999813 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
MARK3 |
0.778 | 0.550 | 4 | 0.550 |
MARK4 |
0.777 | 0.549 | 4 | 0.435 |
MARK2 |
0.775 | 0.552 | 4 | 0.532 |
QSK |
0.774 | 0.488 | 4 | 0.471 |
MARK1 |
0.765 | 0.496 | 4 | 0.491 |
SIK |
0.763 | 0.393 | -3 | 0.746 |
CDC7 |
0.755 | 0.111 | 1 | 0.911 |
QIK |
0.755 | 0.384 | -3 | 0.826 |
AMPKA1 |
0.754 | 0.284 | -3 | 0.831 |
NIM1 |
0.751 | 0.367 | 3 | 0.754 |
AMPKA2 |
0.751 | 0.247 | -3 | 0.796 |
MTOR |
0.747 | 0.200 | 1 | 0.788 |
NUAK2 |
0.746 | 0.167 | -3 | 0.819 |
TSSK1 |
0.746 | 0.216 | -3 | 0.847 |
COT |
0.745 | 0.020 | 2 | 0.884 |
NDR2 |
0.745 | 0.086 | -3 | 0.812 |
BRSK1 |
0.742 | 0.212 | -3 | 0.770 |
BRSK2 |
0.737 | 0.212 | -3 | 0.795 |
PIM3 |
0.737 | 0.017 | -3 | 0.812 |
ATR |
0.737 | 0.090 | 1 | 0.919 |
PRPK |
0.736 | -0.004 | -1 | 0.260 |
MST4 |
0.736 | 0.112 | 2 | 0.875 |
NUAK1 |
0.736 | 0.155 | -3 | 0.766 |
HUNK |
0.736 | 0.105 | 2 | 0.779 |
RSK2 |
0.736 | 0.046 | -3 | 0.753 |
CDKL1 |
0.735 | 0.076 | -3 | 0.794 |
RAF1 |
0.734 | 0.011 | 1 | 0.862 |
CAMK1B |
0.734 | 0.058 | -3 | 0.846 |
BCKDK |
0.734 | 0.016 | -1 | 0.282 |
NDR1 |
0.733 | 0.060 | -3 | 0.809 |
MOS |
0.733 | -0.002 | 1 | 0.908 |
PDHK4 |
0.733 | 0.001 | 1 | 0.871 |
TSSK2 |
0.732 | 0.139 | -5 | 0.877 |
WNK1 |
0.732 | 0.047 | -2 | 0.903 |
GCN2 |
0.731 | -0.048 | 2 | 0.800 |
HIPK4 |
0.731 | 0.079 | 1 | 0.788 |
P90RSK |
0.731 | 0.037 | -3 | 0.760 |
CLK3 |
0.730 | 0.016 | 1 | 0.831 |
SKMLCK |
0.730 | 0.049 | -2 | 0.885 |
PRKD1 |
0.729 | 0.007 | -3 | 0.805 |
ATM |
0.729 | 0.056 | 1 | 0.882 |
RSK3 |
0.729 | 0.041 | -3 | 0.750 |
CAMK2G |
0.729 | -0.038 | 2 | 0.823 |
SSTK |
0.728 | 0.223 | 4 | 0.397 |
PDHK1 |
0.726 | -0.033 | 1 | 0.836 |
NLK |
0.726 | -0.007 | 1 | 0.814 |
CDKL5 |
0.726 | 0.044 | -3 | 0.786 |
ULK2 |
0.726 | -0.039 | 2 | 0.773 |
PIM1 |
0.726 | 0.023 | -3 | 0.757 |
LATS2 |
0.726 | 0.003 | -5 | 0.778 |
PKACG |
0.726 | 0.037 | -2 | 0.772 |
NIK |
0.725 | 0.038 | -3 | 0.865 |
DNAPK |
0.725 | 0.119 | 1 | 0.763 |
PRKD2 |
0.725 | -0.002 | -3 | 0.746 |
BMPR2 |
0.725 | -0.106 | -2 | 0.892 |
CAMK2B |
0.724 | 0.011 | 2 | 0.804 |
GRK1 |
0.724 | -0.022 | -2 | 0.859 |
IKKB |
0.724 | -0.107 | -2 | 0.792 |
CAMK2D |
0.724 | 0.002 | -3 | 0.831 |
DAPK2 |
0.724 | 0.036 | -3 | 0.857 |
GRK5 |
0.724 | -0.079 | -3 | 0.852 |
TBK1 |
0.724 | -0.051 | 1 | 0.726 |
PKCD |
0.724 | 0.061 | 2 | 0.795 |
FAM20C |
0.724 | 0.026 | 2 | 0.603 |
WNK3 |
0.723 | -0.031 | 1 | 0.849 |
DSTYK |
0.723 | -0.077 | 2 | 0.896 |
CAMLCK |
0.722 | 0.020 | -2 | 0.877 |
GRK6 |
0.722 | -0.034 | 1 | 0.908 |
PKN2 |
0.722 | 0.020 | -3 | 0.818 |
NEK6 |
0.722 | -0.070 | -2 | 0.853 |
MAPKAPK2 |
0.722 | 0.008 | -3 | 0.707 |
PKN3 |
0.722 | -0.004 | -3 | 0.814 |
MAPKAPK3 |
0.722 | -0.013 | -3 | 0.757 |
MELK |
0.721 | 0.073 | -3 | 0.783 |
P70S6KB |
0.721 | 0.002 | -3 | 0.780 |
GSK3B |
0.720 | -0.036 | 4 | 0.059 |
ICK |
0.720 | 0.040 | -3 | 0.824 |
ERK5 |
0.720 | -0.024 | 1 | 0.757 |
NEK7 |
0.720 | -0.076 | -3 | 0.873 |
CAMK2A |
0.720 | -0.005 | 2 | 0.820 |
AURC |
0.720 | 0.018 | -2 | 0.692 |
TGFBR2 |
0.720 | -0.053 | -2 | 0.775 |
RSK4 |
0.719 | 0.037 | -3 | 0.717 |
GSK3A |
0.719 | -0.012 | 4 | 0.060 |
SMG1 |
0.718 | 0.018 | 1 | 0.876 |
PKACB |
0.718 | 0.055 | -2 | 0.701 |
PKCB |
0.718 | 0.043 | 2 | 0.752 |
IKKE |
0.718 | -0.092 | 1 | 0.712 |
RIPK3 |
0.717 | -0.087 | 3 | 0.644 |
MSK2 |
0.717 | 0.011 | -3 | 0.729 |
MASTL |
0.717 | -0.013 | -2 | 0.850 |
PKCG |
0.717 | 0.042 | 2 | 0.749 |
IKKA |
0.717 | -0.066 | -2 | 0.780 |
PRKX |
0.716 | 0.049 | -3 | 0.646 |
IRE1 |
0.716 | -0.042 | 1 | 0.845 |
PKCA |
0.716 | 0.063 | 2 | 0.739 |
MNK2 |
0.716 | 0.007 | -2 | 0.816 |
MLK1 |
0.716 | -0.098 | 2 | 0.821 |
RIPK1 |
0.716 | -0.065 | 1 | 0.877 |
SRPK1 |
0.715 | 0.004 | -3 | 0.733 |
CDK8 |
0.715 | 0.016 | 1 | 0.618 |
GRK7 |
0.714 | 0.046 | 1 | 0.836 |
MSK1 |
0.714 | 0.016 | -3 | 0.734 |
GRK4 |
0.714 | -0.083 | -2 | 0.855 |
CAMK1G |
0.714 | 0.071 | -3 | 0.746 |
CHAK2 |
0.714 | -0.101 | -1 | 0.188 |
CAMK4 |
0.714 | -0.021 | -3 | 0.796 |
NEK9 |
0.714 | -0.069 | 2 | 0.839 |
CDK7 |
0.714 | -0.003 | 1 | 0.626 |
BMPR1B |
0.713 | 0.028 | 1 | 0.886 |
LATS1 |
0.713 | 0.017 | -3 | 0.829 |
ULK1 |
0.712 | -0.094 | -3 | 0.843 |
SGK3 |
0.711 | 0.069 | -3 | 0.743 |
TGFBR1 |
0.711 | -0.001 | -2 | 0.787 |
MPSK1 |
0.711 | 0.139 | 1 | 0.793 |
PAK1 |
0.711 | -0.012 | -2 | 0.822 |
CDK19 |
0.710 | 0.022 | 1 | 0.572 |
MLK2 |
0.710 | -0.098 | 2 | 0.825 |
SRPK2 |
0.710 | 0.007 | -3 | 0.661 |
MYLK4 |
0.710 | 0.020 | -2 | 0.798 |
DLK |
0.710 | -0.136 | 1 | 0.888 |
PKCZ |
0.710 | -0.006 | 2 | 0.789 |
CHK1 |
0.710 | 0.034 | -3 | 0.804 |
PRKD3 |
0.710 | -0.005 | -3 | 0.721 |
DYRK2 |
0.710 | 0.021 | 1 | 0.663 |
PAK3 |
0.709 | -0.021 | -2 | 0.816 |
CLK2 |
0.709 | 0.048 | -3 | 0.721 |
MNK1 |
0.709 | 0.004 | -2 | 0.825 |
AURB |
0.709 | 0.012 | -2 | 0.691 |
KIS |
0.709 | -0.002 | 1 | 0.639 |
NEK2 |
0.708 | -0.009 | 2 | 0.819 |
MEK1 |
0.708 | 0.026 | 2 | 0.828 |
PKCH |
0.707 | 0.007 | 2 | 0.726 |
WNK4 |
0.707 | 0.026 | -2 | 0.898 |
DCAMKL1 |
0.706 | 0.063 | -3 | 0.757 |
ALK4 |
0.706 | -0.049 | -2 | 0.820 |
PIM2 |
0.706 | 0.020 | -3 | 0.730 |
AKT2 |
0.706 | 0.025 | -3 | 0.670 |
IRE2 |
0.706 | -0.038 | 2 | 0.743 |
CDK18 |
0.705 | 0.029 | 1 | 0.553 |
PKR |
0.705 | -0.062 | 1 | 0.879 |
PKG2 |
0.705 | 0.001 | -2 | 0.703 |
SNRK |
0.705 | 0.015 | 2 | 0.657 |
MLK3 |
0.705 | -0.084 | 2 | 0.755 |
ANKRD3 |
0.705 | -0.118 | 1 | 0.886 |
PAK2 |
0.705 | -0.013 | -2 | 0.812 |
CLK4 |
0.705 | 0.007 | -3 | 0.746 |
SRPK3 |
0.705 | -0.000 | -3 | 0.711 |
PLK3 |
0.705 | -0.040 | 2 | 0.758 |
CDK5 |
0.704 | 0.026 | 1 | 0.654 |
PHKG1 |
0.703 | -0.039 | -3 | 0.802 |
VRK2 |
0.703 | -0.073 | 1 | 0.898 |
PLK1 |
0.703 | -0.090 | -2 | 0.799 |
HIPK1 |
0.703 | 0.037 | 1 | 0.680 |
PAK6 |
0.703 | -0.017 | -2 | 0.747 |
ACVR2A |
0.703 | -0.034 | -2 | 0.763 |
MST3 |
0.702 | 0.065 | 2 | 0.850 |
DRAK1 |
0.702 | -0.028 | 1 | 0.880 |
TTBK2 |
0.702 | -0.118 | 2 | 0.692 |
PKACA |
0.702 | 0.040 | -2 | 0.647 |
ALK2 |
0.702 | -0.043 | -2 | 0.804 |
P38A |
0.701 | 0.028 | 1 | 0.645 |
CDK13 |
0.701 | -0.012 | 1 | 0.595 |
CLK1 |
0.701 | 0.007 | -3 | 0.718 |
PKCT |
0.701 | 0.025 | 2 | 0.737 |
CAMK1D |
0.701 | 0.041 | -3 | 0.658 |
TLK2 |
0.701 | -0.057 | 1 | 0.858 |
CK2A2 |
0.700 | 0.016 | 1 | 0.776 |
CHAK1 |
0.700 | -0.110 | 2 | 0.777 |
GRK2 |
0.699 | -0.018 | -2 | 0.751 |
PASK |
0.699 | -0.018 | -3 | 0.833 |
ACVR2B |
0.699 | -0.043 | -2 | 0.777 |
CDK2 |
0.699 | 0.001 | 1 | 0.697 |
HIPK2 |
0.699 | 0.016 | 1 | 0.565 |
PLK4 |
0.699 | 0.038 | 2 | 0.602 |
CDK1 |
0.698 | -0.001 | 1 | 0.598 |
JNK2 |
0.698 | 0.011 | 1 | 0.561 |
YSK4 |
0.698 | -0.086 | 1 | 0.791 |
BRAF |
0.698 | -0.028 | -4 | 0.823 |
P38B |
0.698 | 0.026 | 1 | 0.562 |
AURA |
0.698 | -0.009 | -2 | 0.665 |
AKT1 |
0.697 | 0.036 | -3 | 0.685 |
CDK9 |
0.697 | -0.014 | 1 | 0.600 |
TAO3 |
0.697 | 0.051 | 1 | 0.823 |
DYRK1A |
0.697 | 0.012 | 1 | 0.705 |
JNK3 |
0.697 | 0.000 | 1 | 0.601 |
MAPKAPK5 |
0.697 | -0.073 | -3 | 0.723 |
CDK12 |
0.697 | -0.004 | 1 | 0.565 |
PKCI |
0.697 | 0.014 | 2 | 0.758 |
P70S6K |
0.696 | -0.010 | -3 | 0.699 |
CK1E |
0.696 | -0.002 | -3 | 0.530 |
BMPR1A |
0.696 | -0.002 | 1 | 0.864 |
CDK17 |
0.696 | 0.016 | 1 | 0.501 |
IRAK4 |
0.696 | -0.065 | 1 | 0.849 |
CDK14 |
0.695 | 0.029 | 1 | 0.601 |
MLK4 |
0.695 | -0.123 | 2 | 0.728 |
CDK16 |
0.694 | 0.031 | 1 | 0.521 |
SMMLCK |
0.694 | 0.005 | -3 | 0.802 |
MEK5 |
0.694 | -0.067 | 2 | 0.817 |
MEKK1 |
0.694 | -0.033 | 1 | 0.836 |
MEKK3 |
0.693 | -0.052 | 1 | 0.840 |
PKCE |
0.693 | 0.025 | 2 | 0.732 |
NEK5 |
0.693 | -0.035 | 1 | 0.874 |
CDK10 |
0.693 | 0.015 | 1 | 0.587 |
DYRK4 |
0.693 | 0.015 | 1 | 0.573 |
PHKG2 |
0.693 | -0.015 | -3 | 0.770 |
DYRK3 |
0.693 | 0.025 | 1 | 0.686 |
ERK1 |
0.692 | -0.005 | 1 | 0.550 |
DAPK3 |
0.692 | 0.027 | -3 | 0.774 |
ZAK |
0.692 | -0.064 | 1 | 0.813 |
P38G |
0.692 | 0.009 | 1 | 0.490 |
HIPK3 |
0.691 | -0.001 | 1 | 0.669 |
PERK |
0.691 | -0.119 | -2 | 0.824 |
MEKK2 |
0.691 | -0.004 | 2 | 0.801 |
CK2A1 |
0.691 | -0.003 | 1 | 0.760 |
PAK5 |
0.691 | -0.013 | -2 | 0.700 |
DYRK1B |
0.691 | 0.016 | 1 | 0.612 |
ERK2 |
0.691 | -0.032 | 1 | 0.625 |
HRI |
0.690 | -0.128 | -2 | 0.834 |
LKB1 |
0.690 | -0.009 | -3 | 0.849 |
CAMK1A |
0.690 | 0.056 | -3 | 0.625 |
DCAMKL2 |
0.690 | 0.009 | -3 | 0.780 |
SGK1 |
0.690 | 0.054 | -3 | 0.590 |
GAK |
0.689 | 0.008 | 1 | 0.858 |
MEKK6 |
0.689 | 0.068 | 1 | 0.818 |
MOK |
0.688 | 0.066 | 1 | 0.701 |
PINK1 |
0.688 | -0.095 | 1 | 0.829 |
TAO2 |
0.688 | 0.000 | 2 | 0.851 |
NEK11 |
0.688 | -0.009 | 1 | 0.812 |
TLK1 |
0.687 | -0.088 | -2 | 0.817 |
CAMKK1 |
0.687 | -0.084 | -2 | 0.810 |
GRK3 |
0.687 | -0.024 | -2 | 0.710 |
AKT3 |
0.687 | 0.030 | -3 | 0.605 |
IRAK1 |
0.686 | -0.110 | -1 | 0.191 |
GCK |
0.686 | 0.041 | 1 | 0.818 |
PRP4 |
0.686 | -0.019 | -3 | 0.783 |
DAPK1 |
0.686 | 0.011 | -3 | 0.759 |
CAMKK2 |
0.686 | -0.051 | -2 | 0.803 |
MAK |
0.686 | 0.072 | -2 | 0.802 |
CDK3 |
0.685 | 0.004 | 1 | 0.519 |
NEK4 |
0.685 | 0.008 | 1 | 0.813 |
PAK4 |
0.685 | -0.019 | -2 | 0.702 |
MAP3K15 |
0.685 | 0.085 | 1 | 0.788 |
HPK1 |
0.685 | 0.053 | 1 | 0.791 |
MRCKA |
0.684 | 0.027 | -3 | 0.730 |
ROCK2 |
0.684 | 0.041 | -3 | 0.761 |
NEK8 |
0.683 | -0.085 | 2 | 0.816 |
CK1G1 |
0.683 | -0.015 | -3 | 0.520 |
HGK |
0.682 | 0.022 | 3 | 0.746 |
NEK1 |
0.682 | 0.041 | 1 | 0.842 |
LRRK2 |
0.682 | -0.010 | 2 | 0.846 |
TNIK |
0.682 | 0.025 | 3 | 0.752 |
VRK1 |
0.682 | -0.049 | 2 | 0.837 |
CK1D |
0.682 | -0.011 | -3 | 0.480 |
MINK |
0.681 | 0.021 | 1 | 0.797 |
PDK1 |
0.681 | 0.007 | 1 | 0.809 |
ERK7 |
0.681 | 0.002 | 2 | 0.581 |
MRCKB |
0.681 | 0.016 | -3 | 0.714 |
P38D |
0.681 | -0.003 | 1 | 0.499 |
PKN1 |
0.681 | -0.009 | -3 | 0.712 |
PLK2 |
0.680 | -0.040 | -3 | 0.777 |
CK1A2 |
0.680 | -0.010 | -3 | 0.478 |
YSK1 |
0.680 | 0.060 | 2 | 0.818 |
EEF2K |
0.679 | -0.034 | 3 | 0.739 |
MST2 |
0.679 | -0.015 | 1 | 0.826 |
JNK1 |
0.678 | -0.005 | 1 | 0.556 |
KHS2 |
0.678 | 0.054 | 1 | 0.791 |
BUB1 |
0.678 | -0.001 | -5 | 0.831 |
TTBK1 |
0.678 | -0.109 | 2 | 0.604 |
SBK |
0.678 | 0.026 | -3 | 0.550 |
KHS1 |
0.677 | 0.044 | 1 | 0.771 |
TAK1 |
0.677 | -0.081 | 1 | 0.859 |
CHK2 |
0.677 | -0.013 | -3 | 0.612 |
DMPK1 |
0.676 | 0.052 | -3 | 0.728 |
PBK |
0.676 | 0.022 | 1 | 0.749 |
LOK |
0.675 | -0.055 | -2 | 0.804 |
CDK6 |
0.674 | -0.013 | 1 | 0.570 |
PKG1 |
0.674 | -0.002 | -2 | 0.618 |
CRIK |
0.673 | 0.038 | -3 | 0.685 |
ROCK1 |
0.673 | 0.040 | -3 | 0.728 |
MEK2 |
0.673 | -0.028 | 2 | 0.801 |
HASPIN |
0.673 | -0.033 | -1 | 0.205 |
NEK3 |
0.672 | -0.013 | 1 | 0.772 |
MST1 |
0.671 | -0.033 | 1 | 0.804 |
PDHK3_TYR |
0.671 | 0.098 | 4 | 0.177 |
CDK4 |
0.671 | -0.028 | 1 | 0.552 |
STK33 |
0.670 | -0.088 | 2 | 0.593 |
SLK |
0.667 | -0.089 | -2 | 0.763 |
PDHK4_TYR |
0.666 | 0.085 | 2 | 0.881 |
RIPK2 |
0.666 | -0.121 | 1 | 0.761 |
PKMYT1_TYR |
0.665 | 0.170 | 3 | 0.766 |
MYO3B |
0.665 | 0.016 | 2 | 0.833 |
MAP2K4_TYR |
0.663 | 0.069 | -1 | 0.291 |
TESK1_TYR |
0.661 | -0.007 | 3 | 0.812 |
MAP2K7_TYR |
0.660 | 0.094 | 2 | 0.850 |
TAO1 |
0.660 | -0.020 | 1 | 0.736 |
MAP2K6_TYR |
0.660 | 0.003 | -1 | 0.268 |
BMPR2_TYR |
0.658 | -0.005 | -1 | 0.256 |
LIMK2_TYR |
0.658 | 0.016 | -3 | 0.880 |
YANK3 |
0.657 | -0.036 | 2 | 0.386 |
ASK1 |
0.656 | 0.001 | 1 | 0.774 |
BIKE |
0.656 | -0.018 | 1 | 0.709 |
MYO3A |
0.655 | 0.001 | 1 | 0.804 |
OSR1 |
0.655 | -0.098 | 2 | 0.801 |
LIMK1_TYR |
0.654 | 0.019 | 2 | 0.845 |
PDHK1_TYR |
0.654 | -0.043 | -1 | 0.235 |
ALPHAK3 |
0.654 | -0.082 | -1 | 0.187 |
PINK1_TYR |
0.654 | -0.054 | 1 | 0.884 |
TTK |
0.652 | -0.092 | -2 | 0.807 |
CK1A |
0.647 | -0.029 | -3 | 0.388 |
DDR1 |
0.645 | -0.096 | 4 | 0.164 |
EPHA6 |
0.644 | -0.102 | -1 | 0.166 |
TYK2 |
0.644 | -0.079 | 1 | 0.819 |
TXK |
0.644 | -0.048 | 1 | 0.909 |
AAK1 |
0.642 | 0.014 | 1 | 0.586 |
RET |
0.642 | -0.157 | 1 | 0.832 |
TNNI3K_TYR |
0.642 | 0.017 | 1 | 0.819 |
MST1R |
0.640 | -0.134 | 3 | 0.691 |
ABL2 |
0.640 | -0.103 | -1 | 0.185 |
EPHB4 |
0.640 | -0.136 | -1 | 0.160 |
ROS1 |
0.640 | -0.101 | 3 | 0.662 |
TYRO3 |
0.640 | -0.140 | 3 | 0.688 |
FER |
0.640 | -0.131 | 1 | 0.918 |
NEK10_TYR |
0.639 | -0.027 | 1 | 0.696 |
ABL1 |
0.639 | -0.093 | -1 | 0.190 |
YES1 |
0.639 | -0.097 | -1 | 0.204 |
FGR |
0.639 | -0.114 | 1 | 0.894 |
TNK1 |
0.638 | -0.047 | 3 | 0.678 |
JAK2 |
0.637 | -0.111 | 1 | 0.808 |
TEC |
0.637 | -0.099 | -1 | 0.150 |
STLK3 |
0.637 | -0.116 | 1 | 0.783 |
ITK |
0.636 | -0.109 | -1 | 0.171 |
BMX |
0.636 | -0.088 | -1 | 0.136 |
SRMS |
0.636 | -0.131 | 1 | 0.912 |
WEE1_TYR |
0.635 | -0.081 | -1 | 0.187 |
PTK6 |
0.634 | -0.144 | -1 | 0.160 |
TNK2 |
0.634 | -0.109 | 3 | 0.622 |
JAK3 |
0.634 | -0.135 | 1 | 0.828 |
CSF1R |
0.634 | -0.136 | 3 | 0.661 |
JAK1 |
0.633 | -0.027 | 1 | 0.748 |
EPHA4 |
0.633 | -0.093 | 2 | 0.755 |
BTK |
0.633 | -0.150 | -1 | 0.167 |
HCK |
0.633 | -0.135 | -1 | 0.177 |
EPHB1 |
0.633 | -0.147 | 1 | 0.896 |
LCK |
0.632 | -0.111 | -1 | 0.168 |
BLK |
0.632 | -0.067 | -1 | 0.174 |
INSRR |
0.631 | -0.138 | 3 | 0.654 |
EPHB2 |
0.629 | -0.136 | -1 | 0.139 |
MERTK |
0.629 | -0.134 | 3 | 0.668 |
PDGFRB |
0.629 | -0.153 | 3 | 0.687 |
AXL |
0.628 | -0.151 | 3 | 0.666 |
EPHB3 |
0.628 | -0.153 | -1 | 0.143 |
FGFR2 |
0.627 | -0.155 | 3 | 0.709 |
YANK2 |
0.626 | -0.047 | 2 | 0.399 |
TEK |
0.626 | -0.123 | 3 | 0.628 |
FLT3 |
0.626 | -0.151 | 3 | 0.672 |
FYN |
0.626 | -0.086 | -1 | 0.163 |
KIT |
0.626 | -0.154 | 3 | 0.671 |
MET |
0.625 | -0.136 | 3 | 0.661 |
KDR |
0.624 | -0.126 | 3 | 0.633 |
FGFR1 |
0.624 | -0.126 | 3 | 0.665 |
ALK |
0.624 | -0.145 | 3 | 0.608 |
PTK2B |
0.623 | -0.089 | -1 | 0.165 |
CK1G3 |
0.623 | -0.044 | -3 | 0.340 |
LTK |
0.622 | -0.143 | 3 | 0.630 |
DDR2 |
0.622 | -0.086 | 3 | 0.627 |
PDGFRA |
0.622 | -0.171 | 3 | 0.676 |
EPHA3 |
0.621 | -0.141 | 2 | 0.726 |
EPHA7 |
0.620 | -0.137 | 2 | 0.752 |
NTRK1 |
0.620 | -0.179 | -1 | 0.189 |
LYN |
0.620 | -0.124 | 3 | 0.599 |
EPHA1 |
0.619 | -0.155 | 3 | 0.628 |
ERBB2 |
0.618 | -0.142 | 1 | 0.799 |
PTK2 |
0.618 | -0.064 | -1 | 0.156 |
INSR |
0.618 | -0.143 | 3 | 0.626 |
FLT1 |
0.618 | -0.151 | -1 | 0.169 |
FRK |
0.618 | -0.135 | -1 | 0.163 |
MATK |
0.617 | -0.113 | -1 | 0.162 |
NTRK2 |
0.617 | -0.171 | 3 | 0.639 |
SRC |
0.616 | -0.108 | -1 | 0.179 |
FGFR3 |
0.615 | -0.150 | 3 | 0.677 |
NTRK3 |
0.615 | -0.153 | -1 | 0.169 |
EPHA5 |
0.614 | -0.143 | 2 | 0.736 |
FLT4 |
0.613 | -0.165 | 3 | 0.643 |
SYK |
0.613 | -0.084 | -1 | 0.136 |
EGFR |
0.611 | -0.102 | 1 | 0.723 |
CSK |
0.610 | -0.143 | 2 | 0.752 |
EPHA8 |
0.609 | -0.142 | -1 | 0.138 |
MUSK |
0.604 | -0.119 | 1 | 0.709 |
FGFR4 |
0.604 | -0.130 | -1 | 0.158 |
CK1G2 |
0.603 | -0.060 | -3 | 0.435 |
IGF1R |
0.603 | -0.144 | 3 | 0.584 |
EPHA2 |
0.602 | -0.146 | -1 | 0.124 |
FES |
0.601 | -0.117 | -1 | 0.138 |
ERBB4 |
0.599 | -0.095 | 1 | 0.749 |
ZAP70 |
0.590 | -0.077 | -1 | 0.147 |