Motif 849 (n=198)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0AVK6 | E2F8 | S52 | ochoa | Transcription factor E2F8 (E2F-8) | Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. {ECO:0000269|PubMed:15897886, ECO:0000269|PubMed:16179649, ECO:0000269|PubMed:18202719, ECO:0000269|PubMed:22903062}. |
| A0JNW5 | BLTP3B | S953 | ochoa | Bridge-like lipid transfer protein family member 3B (Syntaxin-6 Habc-interacting protein of 164 kDa) (UHRF1-binding protein 1-like) | Tube-forming lipid transport protein which mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567). Required for retrograde traffic of vesicle clusters in the early endocytic pathway to the Golgi complex (PubMed:20163565, PubMed:35499567). {ECO:0000269|PubMed:20163565, ECO:0000269|PubMed:35499567}. |
| A1A4S6 | ARHGAP10 | S600 | ochoa | Rho GTPase-activating protein 10 (GTPase regulator associated with focal adhesion kinase 2) (GRAF2) (Graf-related protein 2) (Rho-type GTPase-activating protein 10) | GTPase-activating protein that catalyzes the conversion of active GTP-bound Rho GTPases to their inactive GDP-bound form, thus suppressing various Rho GTPase-mediated cellular processes (PubMed:11432776). Also converts Cdc42 to an inactive GDP-bound state (PubMed:11432776). Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity). Associates with MICAL1 on the endosomal membrane to promote Rab8-Rab10-dependent tubule extension. After dissociation with MICAL1, recruits WDR44 which connects the endoplasmic reticulum (ER) with the endosomal tubule, thereby participating in the export of a subset of neosynthesized proteins (PubMed:32344433). {ECO:0000250|UniProtKB:Q6Y5D8, ECO:0000269|PubMed:11432776, ECO:0000269|PubMed:32344433}. |
| A2RUS2 | DENND3 | S489 | ochoa | DENN domain-containing protein 3 | Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form (PubMed:20937701). Regulates autophagy in response to starvation through RAB12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards RAB12 (By similarity). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the degradation of the transferrin receptor and of the amino acid transporter PAT4 (PubMed:20937701). Starvation also induces phosphorylation at Tyr-858, which leads to up-regulated GEF activity and initiates autophagy (By similarity). {ECO:0000250|UniProtKB:A2RT67, ECO:0000269|PubMed:20937701}. |
| A6NC98 | CCDC88B | S1444 | ochoa | Coiled-coil domain-containing protein 88B (Brain leucine zipper domain-containing protein) (Gipie) (Hook-related protein 3) (HkRP3) | Acts as a positive regulator of T-cell maturation and inflammatory function. Required for several functions of T-cells, in both the CD4(+) and the CD8(+) compartments and this includes expression of cell surface markers of activation, proliferation, and cytokine production in response to specific or non-specific stimulation (By similarity). Enhances NK cell cytotoxicity by positively regulating polarization of microtubule-organizing center (MTOC) to cytotoxic synapse, lytic granule transport along microtubules, and dynein-mediated clustering to MTOC (PubMed:25762780). Interacts with HSPA5 and stabilizes the interaction between HSPA5 and ERN1, leading to suppression of ERN1-induced JNK activation and endoplasmic reticulum stress-induced apoptosis (PubMed:21289099). {ECO:0000250|UniProtKB:Q4QRL3, ECO:0000269|PubMed:21289099, ECO:0000269|PubMed:25762780}. |
| A6ND36 | FAM83G | S127 | ochoa | Protein FAM83G (Protein associated with SMAD1) | Substrate for type I BMP receptor kinase involved in regulation of some target genes of the BMP signaling pathway. Also regulates the expression of several non-BMP target genes, suggesting a role in other signaling pathways. {ECO:0000269|PubMed:24554596}. |
| A8MQ03 | CYSRT1 | S94 | ochoa | Cysteine-rich tail protein 1 | Component of the stratum corneum that may contribute to epidermal antimicrobial host defenses. {ECO:0000269|PubMed:36804407}. |
| O00192 | ARVCF | S335 | ochoa | Splicing regulator ARVCF (Armadillo repeat protein deleted in velo-cardio-facial syndrome) | Contributes to the regulation of alternative splicing of pre-mRNAs. {ECO:0000269|PubMed:24644279}. |
| O14686 | KMT2D | S2945 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O15014 | ZNF609 | S1055 | ochoa | Zinc finger protein 609 | Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others. {ECO:0000250|UniProtKB:Q8BZ47}.; FUNCTION: [Isoform 2]: Involved in the regulation of myoblast proliferation during myogenesis. {ECO:0000269|PubMed:28344082}. |
| O15018 | PDZD2 | S920 | ochoa | PDZ domain-containing protein 2 (Activated in prostate cancer protein) (PDZ domain-containing protein 3) [Cleaved into: Processed PDZ domain-containing protein 2] | None |
| O15156 | ZBTB7B | S480 | ochoa | Zinc finger and BTB domain-containing protein 7B (Krueppel-related zinc finger protein cKrox) (hcKrox) (T-helper-inducing POZ/Krueppel-like factor) (Zinc finger and BTB domain-containing protein 15) (Zinc finger protein 67 homolog) (Zfp-67) (Zinc finger protein 857B) (Zinc finger protein Th-POK) | Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Exerts distinct biological functions in the mammary epithelial cells and T cells in a tissue-specific manner. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Cross-antagonism between ZBTB7B and CBF complexes are determinative to CD4 versus CD8 cell fate decision. Suppresses RUNX3 expression and imposes CD4+ lineage fate by inducing the SOCS suppressors of cytokine signaling. induces, as a transcriptional activator, SOCS genes expression which represses RUNX3 expression and promotes the CD4+ lineage fate. During CD4 lineage commitment, associates with multiple sites at the CD8 locus, acting as a negative regulator of the CD8 promoter and enhancers by epigenetic silencing through the recruitment of class II histone deacetylases, such as HDAC4 and HDAC5, to these loci. Regulates the development of IL17-producing CD1d-restricted naural killer (NK) T cells. Also functions as an important metabolic regulator in the lactating mammary glands. Critical feed-forward regulator of insulin signaling in mammary gland lactation, directly regulates expression of insulin receptor substrate-1 (IRS-1) and insulin-induced Akt-mTOR-SREBP signaling (By similarity). Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes (PubMed:9370309). Potent driver of brown fat development, thermogenesis and cold-induced beige fat formation. Recruits the brown fat lncRNA 1 (Blnc1):HNRNPU ribonucleoprotein complex to activate thermogenic gene expression in brown and beige adipocytes (By similarity). {ECO:0000250|UniProtKB:Q64321, ECO:0000269|PubMed:9370309}. |
| O15357 | INPPL1 | S1176 | ochoa | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (Protein 51C) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2) | Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:16824732). Required for correct mitotic spindle orientation and therefore progression of mitosis (By similarity). Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear (PubMed:9660833). While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking (By similarity). Confers resistance to dietary obesity (By similarity). May act by regulating AKT2, but not AKT1, phosphorylation at the plasma membrane (By similarity). Part of a signaling pathway that regulates actin cytoskeleton remodeling (PubMed:11739414, PubMed:12676785). Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation (PubMed:15668240). Participates in regulation of cortical and submembraneous actin by hydrolyzing PtdIns(3,4,5)P3 thereby regulating membrane ruffling (PubMed:21624956). Regulates cell adhesion and cell spreading (PubMed:12235291). Required for HGF-mediated lamellipodium formation, cell scattering and spreading (PubMed:15735664). Acts as a negative regulator of EPHA2 receptor endocytosis by inhibiting via PI3K-dependent Rac1 activation (PubMed:17135240). Acts as a regulator of neuritogenesis by regulating PtdIns(3,4,5)P3 level and is required to form an initial protrusive pattern, and later, maintain proper neurite outgrowth (By similarity). Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A) (PubMed:12690104). Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems (PubMed:11016922). Involved in EGF signaling pathway (PubMed:11349134). Upon stimulation by EGF, it is recruited by EGFR and dephosphorylates PtdIns(3,4,5)P3 (PubMed:11349134). Plays a negative role in regulating the PI3K-PKB pathway, possibly by inhibiting PKB activity (PubMed:11349134). Down-regulates Fc-gamma-R-mediated phagocytosis in macrophages independently of INPP5D/SHIP1 (By similarity). In macrophages, down-regulates NF-kappa-B-dependent gene transcription by regulating macrophage colony-stimulating factor (M-CSF)-induced signaling (By similarity). Plays a role in the localization of AURKA and NEDD9/HEF1 to the basolateral membrane at interphase in polarized cysts, thereby mediates cell cycle homeostasis, cell polarization and cilia assembly (By similarity). Additionally promotion of cilia growth is also facilitated by hydrolysis of (PtdIns(3,4,5)P3) to PtdIns(3,4)P2 (By similarity). Promotes formation of apical membrane-initiation sites during the initial stages of lumen formation via Rho family-induced actin filament organization and CTNNB1 localization to cell-cell contacts (By similarity). May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6. Involved in endochondral ossification (PubMed:23273569). {ECO:0000250|UniProtKB:F1PNY0, ECO:0000250|UniProtKB:Q6P549, ECO:0000250|UniProtKB:Q9WVR3, ECO:0000269|PubMed:11016922, ECO:0000269|PubMed:11349134, ECO:0000269|PubMed:11739414, ECO:0000269|PubMed:12235291, ECO:0000269|PubMed:12676785, ECO:0000269|PubMed:12690104, ECO:0000269|PubMed:15668240, ECO:0000269|PubMed:15735664, ECO:0000269|PubMed:16824732, ECO:0000269|PubMed:17135240, ECO:0000269|PubMed:21624956, ECO:0000269|PubMed:23273569, ECO:0000269|PubMed:9660833}. |
| O43379 | WDR62 | S1356 | ochoa | WD repeat-containing protein 62 | Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (PubMed:20729831, PubMed:20890278). Plays a role in mother-centriole-dependent centriole duplication; the function also seems to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). {ECO:0000269|PubMed:20729831, ECO:0000269|PubMed:20890278, ECO:0000269|PubMed:26297806}. |
| O43847 | NRDC | S58 | ochoa | Nardilysin (EC 3.4.24.61) (N-arginine dibasic convertase) (NRD convertase) (NRD-C) (Nardilysin convertase) | Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. Is a critical activator of BACE1- and ADAM17-mediated pro-neuregulin ectodomain shedding, involved in the positive regulation of axonal maturation and myelination. Required for proper functioning of 2-oxoglutarate dehydrogenase (OGDH) (By similarity). {ECO:0000250|UniProtKB:Q8BHG1}. |
| O60292 | SIPA1L3 | S1617 | ochoa | Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) | Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269|PubMed:26231217}. |
| O60292 | SIPA1L3 | S1689 | ochoa | Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) | Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269|PubMed:26231217}. |
| O60336 | MAPKBP1 | S1165 | ochoa | Mitogen-activated protein kinase-binding protein 1 (JNK-binding protein 1) (JNKBP-1) | Negative regulator of NOD2 function. It down-regulates NOD2-induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response (PubMed:22700971). Involved in JNK signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q6NS57, ECO:0000269|PubMed:22700971}. |
| O60356 | NUPR1 | S22 | ochoa | Nuclear protein 1 (Candidate of metastasis 1) (Protein p8) | Transcription regulator that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Thereby participates in the regulation of many processes namely cell-cycle, apoptosis, autophagy and DNA repair responses (PubMed:11056169, PubMed:11940591, PubMed:16300740, PubMed:16478804, PubMed:18690848, PubMed:19650074, PubMed:19723804, PubMed:20181828, PubMed:22565310, PubMed:22858377, PubMed:30451898). Controls cell cycle progression and protects cells from genotoxic stress induced by doxorubicin through the complex formation with TP53 and EP300 that binds CDKN1A promoter leading to transcriptional induction of CDKN1A (PubMed:18690848). Protects pancreatic cancer cells from stress-induced cell death by binding the RELB promoter and activating its transcription, leading to IER3 transactivation (PubMed:22565310). Negatively regulates apoptosis through interaction with PTMA (PubMed:16478804). Inhibits autophagy-induced apoptosis in cardiac cells through FOXO3 interaction, inducing cytoplasmic translocation of FOXO3 thereby preventing the FOXO3 association with the pro-autophagic BNIP3 promoter (PubMed:20181828). Inhibits cell growth and facilitates programmed cell death by apoptosis after adriamycin-induced DNA damage through transactivation of TP53 (By similarity). Regulates methamphetamine-induced apoptosis and autophagy through DDIT3-mediated endoplasmic reticulum stress pathway (By similarity). Participates in DNA repair following gamma-irradiation by facilitating DNA access of the transcription machinery through interaction with MSL1 leading to inhibition of histone H4' Lys-16' acetylation (H4K16ac) (PubMed:19650074). Coactivator of PAX2 transcription factor activity, both by recruiting EP300 to increase PAX2 transcription factor activity and by binding PAXIP1 to suppress PAXIP1-induced inhibition on PAX2 (PubMed:11940591). Positively regulates cell cycle progression through interaction with COPS5 inducing cytoplasmic translocation of CDKN1B leading to the CDKN1B degradation (PubMed:16300740). Coordinates, through its interaction with EP300, the assiociation of MYOD1, EP300 and DDX5 to the MYOG promoter, leading to inhibition of cell-cycle progression and myogenic differentiation promotion (PubMed:19723804). Negatively regulates beta cell proliferation via inhibition of cell-cycle regulatory genes expression through the suppression of their promoter activities (By similarity). Also required for LHB expression and ovarian maturation (By similarity). Exacerbates CNS inflammation and demyelination upon cuprizone treatment (By similarity). {ECO:0000250|UniProtKB:O54842, ECO:0000250|UniProtKB:Q9WTK0, ECO:0000269|PubMed:11056169, ECO:0000269|PubMed:11940591, ECO:0000269|PubMed:16300740, ECO:0000269|PubMed:16478804, ECO:0000269|PubMed:18690848, ECO:0000269|PubMed:19650074, ECO:0000269|PubMed:19723804, ECO:0000269|PubMed:20181828, ECO:0000269|PubMed:22565310, ECO:0000269|PubMed:22858377, ECO:0000269|PubMed:30451898}. |
| O60716 | CTNND1 | S268 | ochoa|psp | Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) | Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:18343367, ECO:0000269|PubMed:20371349}. |
| O60741 | HCN1 | S770 | psp | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1) | Hyperpolarization-activated ion channel that are permeable to sodium and potassium ions (PubMed:15351778, PubMed:28086084). Displays lower selectivity for K(+) over Na(+) ions (PubMed:28086084). Contributes to the native pacemaker currents in heart (If) and in the generation of the I(h) current which controls neuron excitability (PubMed:29936235, PubMed:30351409). Participates in cerebellar mechanisms of motor learning (By similarity). May mediate responses to sour stimuli (By similarity). {ECO:0000250|UniProtKB:O88704, ECO:0000269|PubMed:15351778, ECO:0000269|PubMed:28086084, ECO:0000269|PubMed:29936235, ECO:0000269|PubMed:30351409}. |
| O60825 | PFKFB2 | S466 | ochoa|psp | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (6PF-2-K/Fru-2,6-P2ase 2) (PFK/FBPase 2) (6PF-2-K/Fru-2,6-P2ase heart-type isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)] | Synthesis and degradation of fructose 2,6-bisphosphate. {ECO:0000269|PubMed:11069105}. |
| O60907 | TBL1X | S474 | psp | F-box-like/WD repeat-containing protein TBL1X (SMAP55) (Transducin beta-like protein 1X) (Transducin-beta-like protein 1, X-linked) | F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units (PubMed:14980219). Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (PubMed:21240272). {ECO:0000269|PubMed:14980219, ECO:0000269|PubMed:21240272}. |
| O75061 | DNAJC6 | S624 | ochoa | Auxilin (EC 3.1.3.-) (DnaJ homolog subfamily C member 6) | May act as a protein phosphatase and/or a lipid phosphatase. Co-chaperone that recruits HSPA8/HSC70 to clathrin-coated vesicles (CCVs) and promotes the ATP-dependent dissociation of clathrin from CCVs and participates in clathrin-mediated endocytosis of synaptic vesicles and their recycling and also in intracellular trafficking (PubMed:18489706). Firstly, binds tightly to the clathrin cages, at a ratio of one DNAJC6 per clathrin triskelion. The HSPA8:ATP complex then binds to the clathrin-auxilin cage, initially at a ratio of one HSPA8 per triskelion leading to ATP hydrolysis stimulation and causing a conformational change in the HSPA8. This cycle is repeated three times to drive to a complex containing the clathrin-auxilin cage associated to three HSPA8:ADP complex. The ATP hydrolysis of the third HSPA8:ATP complex leads to a concerted dismantling of the cage into component triskelia. Then, dissociates from the released triskelia and be recycled to initiate another cycle of HSPA8's recruitment. Also acts during the early steps of clathrin-coated vesicle (CCV) formation through its interaction with the GTP bound form of DNM1 (By similarity). {ECO:0000250|UniProtKB:Q27974, ECO:0000269|PubMed:18489706}. |
| O75128 | COBL | S47 | ochoa | Protein cordon-bleu | Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. {ECO:0000250, ECO:0000269|PubMed:21816349}. |
| O75128 | COBL | S974 | ochoa | Protein cordon-bleu | Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. {ECO:0000250, ECO:0000269|PubMed:21816349}. |
| O75140 | DEPDC5 | S579 | ochoa | GATOR1 complex protein DEPDC5 (DEP domain-containing protein 5) | As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the mTORC1 pathway (PubMed:23723238, PubMed:25457612, PubMed:29590090, PubMed:29769719, PubMed:31548394, PubMed:35338845). In response to amino acid depletion, the GATOR1 complex has GTPase activating protein (GAP) activity and strongly increases GTP hydrolysis by RagA/RRAGA (or RagB/RRAGB) within heterodimeric Rag complexes, thereby turning them into their inactive GDP-bound form, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling (PubMed:23723238, PubMed:25457612, PubMed:29590090, PubMed:29769719, PubMed:35338845). In the presence of abundant amino acids, the GATOR1 complex is negatively regulated by GATOR2, the other GATOR subcomplex, in this amino acid-sensing branch of the TORC1 pathway (PubMed:23723238, PubMed:25457612, PubMed:29769719). Within the GATOR1 complex, DEPDC5 mediates direct interaction with the nucleotide-binding pocket of small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD) and coordinates their nucleotide loading states by promoting RagA/RRAGA or RagB/RRAGB into their GDP-binding state and RagC/RRAGC or RagD/RRAGD into their GTP-binding state (PubMed:29590090, PubMed:35338845). However, it does not execute the GAP activity, which is mediated by NPRL2 (PubMed:29590090). {ECO:0000269|PubMed:23723238, ECO:0000269|PubMed:25457612, ECO:0000269|PubMed:29590090, ECO:0000269|PubMed:29769719, ECO:0000269|PubMed:31548394, ECO:0000269|PubMed:35338845}. |
| O75369 | FLNB | S2113 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| O75376 | NCOR1 | S1383 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O75376 | NCOR1 | S2084 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O75962 | TRIO | S2440 | ochoa | Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein) | Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed:22155786, PubMed:27418539, PubMed:8643598). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed:10341202, PubMed:22155786). Plays a key role in the regulation of neurite outgrowth and lamellipodia formation (PubMed:32109419). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (By similarity). {ECO:0000250|UniProtKB:F1M0Z1, ECO:0000269|PubMed:10341202, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:27418539, ECO:0000269|PubMed:32109419, ECO:0000269|PubMed:8643598}. |
| O94913 | PCF11 | S1177 | ochoa | Pre-mRNA cleavage complex 2 protein Pcf11 (Pre-mRNA cleavage complex II protein Pcf11) | Component of pre-mRNA cleavage complex II, which promotes transcription termination by RNA polymerase II. {ECO:0000269|PubMed:11060040, ECO:0000269|PubMed:29196535}. |
| O95180 | CACNA1H | S1099 | ochoa | Voltage-dependent T-type calcium channel subunit alpha-1H (Low-voltage-activated calcium channel alpha1 3.2 subunit) (Voltage-gated calcium channel subunit alpha Cav3.2) | Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group. A particularity of this type of channel is an opening at quite negative potentials, and a voltage-dependent inactivation (PubMed:27149520, PubMed:9670923, PubMed:9930755). T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle (Probable). They may also be involved in the modulation of firing patterns of neurons (PubMed:15048902). In the adrenal zona glomerulosa, participates in the signaling pathway leading to aldosterone production in response to either AGT/angiotensin II, or hyperkalemia (PubMed:25907736, PubMed:27729216). {ECO:0000269|PubMed:24277868, ECO:0000269|PubMed:25907736, ECO:0000269|PubMed:27149520, ECO:0000269|PubMed:27729216, ECO:0000269|PubMed:9670923, ECO:0000269|PubMed:9930755, ECO:0000305, ECO:0000305|PubMed:15048902}. |
| O95229 | ZWINT | S250 | psp | Outer kinetochore KNL1 complex subunit ZWINT (ZW10 interactor) (ZW10-interacting protein 1) (Zwint-1) | Acts as a component of the outer kinetochore KNL1 complex that serves as a docking point for spindle assembly checkpoint components and mediates microtubule-kinetochore interactions (PubMed:15094189, PubMed:15485811, PubMed:15824131, PubMed:16732327, PubMed:24530301, PubMed:27881301, PubMed:38459127, PubMed:38459128). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules (PubMed:15094189, PubMed:15485811, PubMed:16732327). The outer kinetochore is made up of the ten-subunit KMN network, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle (PubMed:15094189, PubMed:15485811, PubMed:15824131, PubMed:16732327, PubMed:24530301, PubMed:38459127, PubMed:38459128). Targets the RZZ complex to the kinetochore at prometaphase (PubMed:15485811). Recruits MAD2L1 to the kinetochore, but is not required for BUB1B localization (By similarity). In addition to orienting mitotic chromosomes, it is also essential for alignment of homologous chromosomes during meiotic metaphase I (By similarity). In meiosis I, required to activate the spindle assembly checkpoint at unattached kinetochores to correct erroneous kinetochore-microtubule attachments (PubMed:15485811). {ECO:0000250|UniProtKB:Q9CQU5, ECO:0000269|PubMed:15094189, ECO:0000269|PubMed:15485811, ECO:0000269|PubMed:15824131, ECO:0000269|PubMed:16732327, ECO:0000269|PubMed:24530301, ECO:0000269|PubMed:27881301, ECO:0000269|PubMed:38459127, ECO:0000269|PubMed:38459128}. |
| O95278 | EPM2A | S25 | psp | Laforin (EC 3.1.3.-) (EC 3.1.3.16) (EC 3.1.3.48) (Glucan phosphatase) (Glycogen phosphatase) (Lafora PTPase) (LAFPTPase) | Plays an important role in preventing glycogen hyperphosphorylation and the formation of insoluble aggregates, via its activity as glycogen phosphatase, and by promoting the ubiquitination of proteins involved in glycogen metabolism via its interaction with the E3 ubiquitin ligase NHLRC1/malin. Shows strong phosphatase activity towards complex carbohydrates in vitro, avoiding glycogen hyperphosphorylation which is associated with reduced branching and formation of insoluble aggregates (PubMed:16901901, PubMed:23922729, PubMed:25538239, PubMed:25544560, PubMed:26231210). Dephosphorylates phosphotyrosine and synthetic substrates, such as para-nitrophenylphosphate (pNPP), and has low activity with phosphoserine and phosphothreonine substrates (in vitro) (PubMed:11001928, PubMed:11220751, PubMed:11739371, PubMed:14532330, PubMed:14722920, PubMed:16971387, PubMed:18617530, PubMed:22036712, PubMed:23922729). Has been shown to dephosphorylate MAPT (By similarity). Forms a complex with NHLRC1/malin and HSP70, which suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Acts as a scaffold protein to facilitate PPP1R3C/PTG ubiquitination by NHLRC1/malin (PubMed:23922729). Also promotes proteasome-independent protein degradation through the macroautophagy pathway (PubMed:20453062). {ECO:0000250|UniProtKB:Q9WUA5, ECO:0000269|PubMed:11001928, ECO:0000269|PubMed:11220751, ECO:0000269|PubMed:11739371, ECO:0000269|PubMed:14532330, ECO:0000269|PubMed:14722920, ECO:0000269|PubMed:16901901, ECO:0000269|PubMed:16971387, ECO:0000269|PubMed:18070875, ECO:0000269|PubMed:18617530, ECO:0000269|PubMed:19036738, ECO:0000269|PubMed:20453062, ECO:0000269|PubMed:22036712, ECO:0000269|PubMed:23624058, ECO:0000269|PubMed:23922729, ECO:0000269|PubMed:25538239, ECO:0000269|PubMed:25544560, ECO:0000269|PubMed:26231210}.; FUNCTION: [Isoform 2]: Does not bind to glycogen (PubMed:18617530). Lacks phosphatase activity and might function as a dominant-negative regulator for the phosphatase activity of isoform 1 and isoform 7 (PubMed:18617530, PubMed:22036712). {ECO:0000269|PubMed:18617530, ECO:0000269|PubMed:22036712}.; FUNCTION: [Isoform 7]: Has phosphatase activity (in vitro). {ECO:0000269|PubMed:22036712}. |
| O95359 | TACC2 | S1635 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| O96013 | PAK4 | S195 | ochoa | Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4) | Serine/threonine-protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell adhesion turnover, cell migration, growth, proliferation or cell survival (PubMed:26598620). Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN. Promotes kinase-independent stabilization of RHOU, thereby contributing to focal adhesion disassembly during cell migration (PubMed:26598620). {ECO:0000269|PubMed:11278822, ECO:0000269|PubMed:11313478, ECO:0000269|PubMed:14560027, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:20507994, ECO:0000269|PubMed:20631255, ECO:0000269|PubMed:20805321, ECO:0000269|PubMed:26598620, ECO:0000269|PubMed:26607847}. |
| P04004 | VTN | S130 | ochoa | Vitronectin (VN) (S-protein) (Serum-spreading factor) (V75) [Cleaved into: Vitronectin V65 subunit; Vitronectin V10 subunit; Somatomedin-B] | Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.; FUNCTION: Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity. |
| P09601 | HMOX1 | S241 | ochoa | Heme oxygenase 1 (HO-1) (EC 1.14.14.18) [Cleaved into: Heme oxygenase 1 soluble form] | [Heme oxygenase 1]: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron (PubMed:11121422, PubMed:19556236, PubMed:7703255). Affords protection against programmed cell death and this cytoprotective effect relies on its ability to catabolize free heme and prevent it from sensitizing cells to undergo apoptosis (PubMed:20055707). {ECO:0000269|PubMed:11121422, ECO:0000269|PubMed:19556236, ECO:0000269|PubMed:7703255, ECO:0000303|PubMed:20055707}.; FUNCTION: [Heme oxygenase 1]: (Microbial infection) During SARS-COV-2 infection, promotes SARS-CoV-2 ORF3A-mediated autophagy but is unlikely to be required for ORF3A-mediated induction of reticulophagy. {ECO:0000269|PubMed:35239449}.; FUNCTION: [Heme oxygenase 1 soluble form]: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. {ECO:0000269|PubMed:7703255}. |
| P14635 | CCNB1 | S35 | ochoa | G2/mitotic-specific cyclin-B1 | Essential for the control of the cell cycle at the G2/M (mitosis) transition. {ECO:0000269|PubMed:17495531, ECO:0000269|PubMed:17495533, ECO:0000269|PubMed:27030811}. |
| P17676 | CEBPB | S141 | ochoa | CCAAT/enhancer-binding protein beta (C/EBP beta) (Liver activator protein) (LAP) (Liver-enriched inhibitory protein) (LIP) (Nuclear factor NF-IL6) (Transcription factor 5) (TCF-5) | Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:12048245, PubMed:1741402, PubMed:18647749, PubMed:9374525). Also plays a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant roles with CEBPA. Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage. Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Also plays a role in intracellular bacteria killing (By similarity). During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation (PubMed:20829347). Essential for female reproduction because of a critical role in ovarian follicle development (By similarity). Restricts osteoclastogenesis: together with NFE2L1; represses expression of DSPP during odontoblast differentiation (By similarity). {ECO:0000250|UniProtKB:P21272, ECO:0000250|UniProtKB:P28033, ECO:0000269|PubMed:12048245, ECO:0000269|PubMed:18647749, ECO:0000269|PubMed:20829347, ECO:0000269|PubMed:9374525, ECO:0000303|PubMed:25451943}.; FUNCTION: [Isoform 2]: Essential for gene expression induction in activated macrophages. Plays a major role in immune responses such as CD4(+) T-cell response, granuloma formation and endotoxin shock. Not essential for intracellular bacteria killing. {ECO:0000250|UniProtKB:P28033}.; FUNCTION: [Isoform 3]: Acts as a dominant negative through heterodimerization with isoform 2 (PubMed:11741938). Promotes osteoblast differentiation and osteoclastogenesis (By similarity). {ECO:0000250|UniProtKB:P21272, ECO:0000250|UniProtKB:P28033, ECO:0000269|PubMed:11741938}. |
| P21359 | NF1 | S2484 | ochoa | Neurofibromin (Neurofibromatosis-related protein NF-1) [Cleaved into: Neurofibromin truncated] | Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity. {ECO:0000269|PubMed:2121371, ECO:0000269|PubMed:8417346}. |
| P27708 | CAD | S1859 | ochoa|psp | Multifunctional protein CAD (Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase) [Includes: Glutamine-dependent carbamoyl phosphate synthase (EC 6.3.5.5); Glutamine amidotransferase (GATase) (GLNase) (EC 3.5.1.2); Ammonium-dependent carbamoyl phosphate synthase (CPS) (CPSase) (EC 6.3.4.16); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)] | Multifunctional protein that encodes the first 3 enzymatic activities of the de novo pyrimidine pathway: carbamoylphosphate synthetase (CPSase; EC 6.3.5.5), aspartate transcarbamylase (ATCase; EC 2.1.3.2) and dihydroorotase (DHOase; EC 3.5.2.3). The CPSase-function is accomplished in 2 steps, by a glutamine-dependent amidotransferase activity (GATase) that binds and cleaves glutamine to produce ammonia, followed by an ammonium-dependent carbamoyl phosphate synthetase, which reacts with the ammonia, hydrogencarbonate and ATP to form carbamoyl phosphate. The endogenously produced carbamoyl phosphate is sequestered and channeled to the ATCase active site. ATCase then catalyzes the formation of carbamoyl-L-aspartate from L-aspartate and carbamoyl phosphate. In the last step, DHOase catalyzes the cyclization of carbamoyl aspartate to dihydroorotate. {ECO:0000269|PubMed:24332717}. |
| P31327 | CPS1 | S835 | ochoa | Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I) | Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. |
| P31629 | HIVEP2 | S1622 | ochoa | Transcription factor HIVEP2 (Human immunodeficiency virus type I enhancer-binding protein 2) (HIV-EP2) (MHC-binding protein 2) (MBP-2) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation. |
| P35568 | IRS1 | S547 | ochoa | Insulin receptor substrate 1 (IRS-1) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:19639489, ECO:0000269|PubMed:38625937, ECO:0000269|PubMed:7541045, ECO:0000269|PubMed:8265614}. |
| P42226 | STAT6 | S756 | psp | Signal transducer and activator of transcription 6 (IL-4 Stat) | Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling. {ECO:0000269|PubMed:17210636, ECO:0000269|PubMed:36758835, ECO:0000269|PubMed:36884218}. |
| P42345 | MTOR | S1261 | ochoa|psp | Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin and FKBP12 target 1) (Rapamycin target protein 1) (Tyrosine-protein kinase mTOR) (EC 2.7.10.2) | Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals (PubMed:12087098, PubMed:12150925, PubMed:12150926, PubMed:12231510, PubMed:12718876, PubMed:14651849, PubMed:15268862, PubMed:15467718, PubMed:15545625, PubMed:15718470, PubMed:18497260, PubMed:18762023, PubMed:18925875, PubMed:20516213, PubMed:20537536, PubMed:21659604, PubMed:23429703, PubMed:23429704, PubMed:25799227, PubMed:26018084, PubMed:29150432, PubMed:29236692, PubMed:31112131, PubMed:31601708, PubMed:32561715, PubMed:34519269, PubMed:37751742). MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins (PubMed:15268862, PubMed:15467718, PubMed:17517883, PubMed:18372248, PubMed:18497260, PubMed:18925875, PubMed:20516213, PubMed:21576368, PubMed:21659604, PubMed:23429704, PubMed:30171069, PubMed:29236692, PubMed:37751742). Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2) (PubMed:15268862, PubMed:15467718, PubMed:18497260, PubMed:18925875, PubMed:20516213, PubMed:21576368, PubMed:21659604, PubMed:23429704, PubMed:29424687, PubMed:29567957, PubMed:35926713). In response to nutrients, growth factors or amino acids, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis (PubMed:12087098, PubMed:12150925, PubMed:12150926, PubMed:12231510, PubMed:12718876, PubMed:14651849, PubMed:15268862, PubMed:15467718, PubMed:15545625, PubMed:15718470, PubMed:18497260, PubMed:18762023, PubMed:18925875, PubMed:20516213, PubMed:20537536, PubMed:21659604, PubMed:23429703, PubMed:23429704, PubMed:25799227, PubMed:26018084, PubMed:29150432, PubMed:29236692, PubMed:31112131, PubMed:34519269). This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E) (PubMed:24403073, PubMed:29236692). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4 (PubMed:12087098, PubMed:12150925, PubMed:18925875, PubMed:29150432, PubMed:29236692). Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation, through transcriptional enhancement of the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex (PubMed:23429703, PubMed:23429704). Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor (PubMed:20516213). Activates dormant ribosomes by mediating phosphorylation of SERBP1, leading to SERBP1 inactivation and reactivation of translation (PubMed:36691768). In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1 (PubMed:23426360). To maintain energy homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A (By similarity). In the same time, mTORC1 inhibits catabolic pathways: negatively regulates autophagy through phosphorylation of ULK1 (PubMed:32561715). Under nutrient sufficiency, phosphorylates ULK1 at 'Ser-758', disrupting the interaction with AMPK and preventing activation of ULK1 (PubMed:32561715). Also prevents autophagy through phosphorylation of the autophagy inhibitor DAP (PubMed:20537536). Also prevents autophagy by phosphorylating RUBCNL/Pacer under nutrient-rich conditions (PubMed:30704899). Prevents autophagy by mediating phosphorylation of AMBRA1, thereby inhibiting AMBRA1 ability to mediate ubiquitination of ULK1 and interaction between AMBRA1 and PPP2CA (PubMed:23524951, PubMed:25438055). mTORC1 exerts a feedback control on upstream growth factor signaling that includes phosphorylation and activation of GRB10 a INSR-dependent signaling suppressor (PubMed:21659604). Among other potential targets mTORC1 may phosphorylate CLIP1 and regulate microtubules (PubMed:12231510). The mTORC1 complex is inhibited in response to starvation and amino acid depletion (PubMed:12150925, PubMed:12150926, PubMed:24403073, PubMed:31695197). The non-canonical mTORC1 complex, which acts independently of RHEB, specifically mediates phosphorylation of MiT/TFE factors MITF, TFEB and TFE3 in the presence of nutrients, promoting their cytosolic retention and inactivation (PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:24448649, PubMed:32612235, PubMed:36608670, PubMed:36697823). Upon starvation or lysosomal stress, inhibition of mTORC1 induces dephosphorylation and nuclear translocation of TFEB and TFE3, promoting their transcription factor activity (PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:24448649, PubMed:32612235, PubMed:36608670). The mTORC1 complex regulates pyroptosis in macrophages by promoting GSDMD oligomerization (PubMed:34289345). MTOR phosphorylates RPTOR which in turn inhibits mTORC1 (By similarity). As part of the mTORC2 complex, MTOR transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15268862, PubMed:15467718, PubMed:24670654, PubMed:29424687, PubMed:29567957, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:15268862, PubMed:15467718, PubMed:21376236, PubMed:24670654, PubMed:29424687, PubMed:29567957, PubMed:35926713). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:15467718). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:15718470, PubMed:21376236, PubMed:24670654, PubMed:29424687, PubMed:29567957). mTORC2 also regulates the phosphorylation of SGK1 at 'Ser-422' (PubMed:18925875). mTORC2 may regulate the actin cytoskeleton, through phosphorylation of PRKCA, PXN and activation of the Rho-type guanine nucleotide exchange factors RHOA and RAC1A or RAC1B (PubMed:15268862). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). May also regulate insulin signaling by acting as a tyrosine protein kinase that catalyzes phosphorylation of IGF1R and INSR; additional evidence are however required to confirm this result in vivo (PubMed:26584640). Regulates osteoclastogenesis by adjusting the expression of CEBPB isoforms (By similarity). Plays an important regulatory role in the circadian clock function; regulates period length and rhythm amplitude of the suprachiasmatic nucleus (SCN) and liver clocks (By similarity). {ECO:0000250|UniProtKB:Q9JLN9, ECO:0000269|PubMed:12087098, ECO:0000269|PubMed:12150925, ECO:0000269|PubMed:12150926, ECO:0000269|PubMed:12231510, ECO:0000269|PubMed:12718876, ECO:0000269|PubMed:14651849, ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15545625, ECO:0000269|PubMed:15718470, ECO:0000269|PubMed:17517883, ECO:0000269|PubMed:18372248, ECO:0000269|PubMed:18497260, ECO:0000269|PubMed:18762023, ECO:0000269|PubMed:18925875, ECO:0000269|PubMed:20516213, ECO:0000269|PubMed:20537536, ECO:0000269|PubMed:21376236, ECO:0000269|PubMed:21576368, ECO:0000269|PubMed:21659604, ECO:0000269|PubMed:22343943, ECO:0000269|PubMed:22576015, ECO:0000269|PubMed:22692423, ECO:0000269|PubMed:23426360, ECO:0000269|PubMed:23429703, ECO:0000269|PubMed:23429704, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:24403073, ECO:0000269|PubMed:24448649, ECO:0000269|PubMed:24670654, ECO:0000269|PubMed:25438055, ECO:0000269|PubMed:25799227, ECO:0000269|PubMed:26018084, ECO:0000269|PubMed:26584640, ECO:0000269|PubMed:29150432, ECO:0000269|PubMed:29236692, ECO:0000269|PubMed:29424687, ECO:0000269|PubMed:29567957, ECO:0000269|PubMed:30171069, ECO:0000269|PubMed:30704899, ECO:0000269|PubMed:31112131, ECO:0000269|PubMed:31601708, ECO:0000269|PubMed:31695197, ECO:0000269|PubMed:32561715, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:34289345, ECO:0000269|PubMed:34519269, ECO:0000269|PubMed:35926713, ECO:0000269|PubMed:36608670, ECO:0000269|PubMed:36691768, ECO:0000269|PubMed:36697823, ECO:0000269|PubMed:37751742}. |
| P42356 | PI4KA | S763 | ochoa | Phosphatidylinositol 4-kinase alpha (PI4-kinase alpha) (PI4K-alpha) (PtdIns-4-kinase alpha) (EC 2.7.1.67) (Phosphatidylinositol 4-Kinase III alpha) | Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate. {ECO:0000269|PubMed:10101268, ECO:0000269|PubMed:23229899}. |
| P42566 | EPS15 | S790 | ochoa | Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p) | Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:16903783, ECO:0000269|PubMed:18362181, ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170}. |
| P46013 | MKI67 | S2239 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46379 | BAG6 | S218 | psp | Large proline-rich protein BAG6 (BAG family molecular chaperone regulator 6) (BCL2-associated athanogene 6) (BAG-6) (HLA-B-associated transcript 3) (Protein G3) (Protein Scythe) | ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins (PubMed:21636303). Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20516149, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20516149, PubMed:20676083, PubMed:25535373, PubMed:28104892). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated by RNF126, an E3 ubiquitin-protein ligase associated with BAG6 and are sorted to the proteasome (PubMed:24981174, PubMed:27193484, PubMed:28104892). SGTA which prevents the recruitment of RNF126 to BAG6 may negatively regulate the ubiquitination and the proteasomal degradation of client proteins (PubMed:23129660, PubMed:25179605, PubMed:27193484). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303). BAG6 is also required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome. In this context, it may participate in the production of antigenic peptides and play a role in antigen presentation in immune response (By similarity). BAG6 is also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. BAG6 may ensure the proper degradation of these proteins and thereby protects the endoplasmic reticulum from protein overload upon stress (PubMed:26565908). By inhibiting the polyubiquitination and subsequent proteasomal degradation of HSPA2 it may also play a role in the assembly of the synaptonemal complex during spermatogenesis (By similarity). Also positively regulates apoptosis by interacting with and stabilizing the proapoptotic factor AIFM1 (By similarity). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:Q9Z1R2, ECO:0000269|PubMed:20516149, ECO:0000269|PubMed:20676083, ECO:0000269|PubMed:21636303, ECO:0000269|PubMed:21743475, ECO:0000269|PubMed:23129660, ECO:0000269|PubMed:24981174, ECO:0000269|PubMed:25179605, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:27193484, ECO:0000269|PubMed:28104892}.; FUNCTION: Involved in DNA damage-induced apoptosis: following DNA damage, accumulates in the nucleus and forms a complex with p300/EP300, enhancing p300/EP300-mediated p53/TP53 acetylation leading to increase p53/TP53 transcriptional activity (PubMed:17403783). When nuclear, may also act as a component of some chromatin regulator complex that regulates histone 3 'Lys-4' dimethylation (H3K4me2) (PubMed:18765639). {ECO:0000269|PubMed:17403783, ECO:0000269|PubMed:18765639}.; FUNCTION: Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC). {ECO:0000269|PubMed:18055229, ECO:0000269|PubMed:18852879}.; FUNCTION: Mediates ricin-induced apoptosis. {ECO:0000269|PubMed:14960581}. |
| P48307 | TFPI2 | S168 | ochoa | Tissue factor pathway inhibitor 2 (TFPI-2) (Placental protein 5) (PP5) | May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin. {ECO:0000269|PubMed:7872799}. |
| P51582 | P2RY4 | S333 | psp | P2Y purinoceptor 4 (P2Y4) (P2P) (Uridine nucleotide receptor) (UNR) | Receptor for UTP and UDP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. Not activated by ATP or ADP. |
| P53350 | PLK1 | S330 | psp | Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13) | Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis (PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:23455478, PubMed:23509069, PubMed:28512243, PubMed:8991084). Polo-like kinase proteins act by binding and phosphorylating proteins that are already phosphorylated on a specific motif recognized by the POLO box domains (PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:23455478, PubMed:23509069, PubMed:28512243, PubMed:8991084). Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, MRE11, PPP1R12A/MYPT1, POLQ, PRC1, RACGAP1/CYK4, RAD51, RHNO1, SGO1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1, WEE1 and HNRNPU (PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17218258, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:22325354, PubMed:23455478, PubMed:23509069, PubMed:25986610, PubMed:26811421, PubMed:28512243, PubMed:37440612, PubMed:37674080, PubMed:8991084). Plays a key role in centrosome functions and the assembly of bipolar spindles by phosphorylating KIZ, NEDD1 and NINL (PubMed:16980960, PubMed:19509060). NEDD1 phosphorylation promotes subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation (PubMed:19509060). Phosphorylation of NINL component of the centrosome leads to NINL dissociation from other centrosomal proteins (PubMed:12852856). Involved in mitosis exit and cytokinesis by phosphorylating CEP55, ECT2, KIF20A/MKLP2, CENPU, PRC1 and RACGAP1 (PubMed:12939256, PubMed:16247472, PubMed:17351640, PubMed:19468300, PubMed:19468302). Recruited at the central spindle by phosphorylating and docking PRC1 and KIF20A/MKLP2; creates its own docking sites on PRC1 and KIF20A/MKLP2 by mediating phosphorylation of sites subsequently recognized by the POLO box domains (PubMed:12939256, PubMed:17351640). Phosphorylates RACGAP1, thereby creating a docking site for the Rho GTP exchange factor ECT2 that is essential for the cleavage furrow formation (PubMed:19468300, PubMed:19468302). Promotes the central spindle recruitment of ECT2 (PubMed:16247472). Plays a central role in G2/M transition of mitotic cell cycle by phosphorylating CCNB1, CDC25C, FOXM1, CENPU, PKMYT1/MYT1, PPP1R12A/MYPT1 and WEE1 (PubMed:11202906, PubMed:12447691, PubMed:12524548, PubMed:19160488). Part of a regulatory circuit that promotes the activation of CDK1 by phosphorylating the positive regulator CDC25C and inhibiting the negative regulators WEE1 and PKMYT1/MYT1 (PubMed:11202906). Also acts by mediating phosphorylation of cyclin-B1 (CCNB1) on centrosomes in prophase (PubMed:12447691, PubMed:12524548). Phosphorylates FOXM1, a key mitotic transcription regulator, leading to enhance FOXM1 transcriptional activity (PubMed:19160488). Involved in kinetochore functions and sister chromatid cohesion by phosphorylating BUB1B/BUBR1, FBXO5/EMI1 and STAG2/SA2 (PubMed:15148369, PubMed:15469984, PubMed:17376779, PubMed:18331714). PLK1 is high on non-attached kinetochores suggesting a role of PLK1 in kinetochore attachment or in spindle assembly checkpoint (SAC) regulation (PubMed:17617734). Required for kinetochore localization of BUB1B (PubMed:17376779). Regulates the dissociation of cohesin from chromosomes by phosphorylating cohesin subunits such as STAG2/SA2 (By similarity). Phosphorylates SGO1: required for spindle pole localization of isoform 3 of SGO1 and plays a role in regulating its centriole cohesion function (PubMed:18331714). Mediates phosphorylation of FBXO5/EMI1, a negative regulator of the APC/C complex during prophase, leading to FBXO5/EMI1 ubiquitination and degradation by the proteasome (PubMed:15148369, PubMed:15469984). Acts as a negative regulator of p53 family members: phosphorylates TOPORS, leading to inhibit the sumoylation of p53/TP53 and simultaneously enhance the ubiquitination and subsequent degradation of p53/TP53 (PubMed:19473992). Phosphorylates the transactivation domain of the transcription factor p73/TP73, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates BORA, and thereby promotes the degradation of BORA (PubMed:18521620). Contributes to the regulation of AURKA function (PubMed:18615013, PubMed:18662541). Also required for recovery after DNA damage checkpoint and entry into mitosis (PubMed:18615013, PubMed:18662541). Phosphorylates MISP, leading to stabilization of cortical and astral microtubule attachments required for proper spindle positioning (PubMed:23509069). Together with MEIKIN, acts as a regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage (By similarity). Phosphorylates CEP68 and is required for its degradation (PubMed:25503564). Regulates nuclear envelope breakdown during prophase by phosphorylating DCTN1 resulting in its localization in the nuclear envelope (PubMed:20679239). Phosphorylates the heat shock transcription factor HSF1, promoting HSF1 nuclear translocation upon heat shock (PubMed:15661742). Phosphorylates HSF1 also in the early mitotic period; this phosphorylation regulates HSF1 localization to the spindle pole, the recruitment of the SCF(BTRC) ubiquitin ligase complex induicing HSF1 degradation, and hence mitotic progression (PubMed:18794143). Regulates mitotic progression by phosphorylating RIOK2 (PubMed:21880710). Through the phosphorylation of DZIP1 regulates the localization during mitosis of the BBSome, a ciliary protein complex involved in cilium biogenesis (PubMed:27979967). Regulates DNA repair during mitosis by mediating phosphorylation of POLQ and RHNO1, thereby promoting POLQ recruitment to DNA damage sites (PubMed:37440612, PubMed:37674080). Phosphorylates ATXN10 which may play a role in the regulation of cytokinesis and may stimulate the proteasome-mediated degradation of ATXN10 (PubMed:21857149). {ECO:0000250|UniProtKB:P70032, ECO:0000250|UniProtKB:Q5F2C3, ECO:0000269|PubMed:11202906, ECO:0000269|PubMed:12207013, ECO:0000269|PubMed:12447691, ECO:0000269|PubMed:12524548, ECO:0000269|PubMed:12738781, ECO:0000269|PubMed:12852856, ECO:0000269|PubMed:12939256, ECO:0000269|PubMed:14532005, ECO:0000269|PubMed:14734534, ECO:0000269|PubMed:15070733, ECO:0000269|PubMed:15148369, ECO:0000269|PubMed:15469984, ECO:0000269|PubMed:15661742, ECO:0000269|PubMed:16198290, ECO:0000269|PubMed:16247472, ECO:0000269|PubMed:16980960, ECO:0000269|PubMed:17081991, ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:17351640, ECO:0000269|PubMed:17376779, ECO:0000269|PubMed:17617734, ECO:0000269|PubMed:18174154, ECO:0000269|PubMed:18331714, ECO:0000269|PubMed:18418051, ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:18521620, ECO:0000269|PubMed:18615013, ECO:0000269|PubMed:18662541, ECO:0000269|PubMed:18794143, ECO:0000269|PubMed:19160488, ECO:0000269|PubMed:19351716, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19468302, ECO:0000269|PubMed:19473992, ECO:0000269|PubMed:19509060, ECO:0000269|PubMed:19597481, ECO:0000269|PubMed:20679239, ECO:0000269|PubMed:21857149, ECO:0000269|PubMed:21880710, ECO:0000269|PubMed:22325354, ECO:0000269|PubMed:23455478, ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:25986610, ECO:0000269|PubMed:26811421, ECO:0000269|PubMed:27979967, ECO:0000269|PubMed:37440612, ECO:0000269|PubMed:37674080, ECO:0000269|PubMed:8991084}. |
| P55060 | CSE1L | S931 | ochoa | Exportin-2 (Exp2) (Cellular apoptosis susceptibility protein) (Chromosome segregation 1-like protein) (Importin-alpha re-exporter) | Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. {ECO:0000269|PubMed:9323134}. |
| Q00587 | CDC42EP1 | S121 | ochoa | Cdc42 effector protein 1 (Binder of Rho GTPases 5) (Serum protein MSE55) | Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts. {ECO:0000269|PubMed:10430899}. |
| Q03164 | KMT2A | S2508 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q07157 | TJP1 | S1111 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q12968 | NFATC3 | S248 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (NFATx) (T-cell transcription factor NFAT4) (NF-AT4) (NF-AT4c) | Acts as a regulator of transcriptional activation. Binds to the TNFSF11/RANKL promoter region and promotes TNFSF11 transcription (By similarity). Binding to the TNFSF11 promoter region is increased by high levels of Ca(2+) which induce NFATC3 expression and may lead to regulation of TNFSF11 expression in osteoblasts (By similarity). Plays a role in promoting mesenteric arterial wall remodeling in response to the intermittent hypoxia-induced increase in EDN1 and ROCK signaling (By similarity). As a result NFATC3 colocalizes with F-actin filaments, translocates to the nucleus and promotes transcription of the smooth muscle hypertrophy and differentiation marker ACTA2 (By similarity). Promotes lipopolysaccharide-induced apoptosis and hypertrophy in cardiomyocytes (By similarity). Following JAK/STAT signaling activation and as part of a complex with NFATC4 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). In conjunction with NFATC4, involved in embryonic heart development via maintenance of cardiomyocyte survival, proliferation and differentiation (By similarity). Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 (PubMed:18815128). Required for thymocyte maturation during DN3 to DN4 transition and during positive selection (By similarity). Positively regulates macrophage-derived polymicrobial clearance, via binding to the promoter region and promoting transcription of NOS2 resulting in subsequent generation of nitric oxide (By similarity). Involved in Ca(2+)-mediated transcriptional responses upon Ca(2+) influx via ORAI1 CRAC channels. {ECO:0000250|UniProtKB:A0A0G2JTY4, ECO:0000250|UniProtKB:P97305, ECO:0000269|PubMed:18815128, ECO:0000269|PubMed:32415068}. |
| Q13153 | PAK1 | S199 | ochoa|psp | Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (Alpha-PAK) (p21-activated kinase 1) (PAK-1) (p65-PAK) | Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes (PubMed:10551809, PubMed:11896197, PubMed:12876277, PubMed:14585966, PubMed:15611088, PubMed:17726028, PubMed:17989089, PubMed:30290153, PubMed:17420447). Can directly phosphorylate BAD and protects cells against apoptosis (By similarity). Activated by interaction with CDC42 and RAC1 (PubMed:8805275, PubMed:9528787). Functions as a GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway (PubMed:8805275, PubMed:9528787). Phosphorylates and activates MAP2K1, and thereby mediates activation of downstream MAP kinases (By similarity). Involved in the reorganization of the actin cytoskeleton, actin stress fibers and of focal adhesion complexes (PubMed:9032240, PubMed:9395435). Phosphorylates the tubulin chaperone TBCB and thereby plays a role in the regulation of microtubule biogenesis and organization of the tubulin cytoskeleton (PubMed:15831477). Plays a role in the regulation of insulin secretion in response to elevated glucose levels (PubMed:22669945). Part of a ternary complex that contains PAK1, DVL1 and MUSK that is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By similarity). Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2 (PubMed:12624090). Phosphorylates MYL9/MLC2 (By similarity). Phosphorylates RAF1 at 'Ser-338' and 'Ser-339' resulting in: activation of RAF1, stimulation of RAF1 translocation to mitochondria, phosphorylation of BAD by RAF1, and RAF1 binding to BCL2 (PubMed:11733498). Phosphorylates SNAI1 at 'Ser-246' promoting its transcriptional repressor activity by increasing its accumulation in the nucleus (PubMed:15833848). In podocytes, promotes NR3C2 nuclear localization (By similarity). Required for atypical chemokine receptor ACKR2-induced phosphorylation of LIMK1 and cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:23633677). In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3, maybe through CFL1 phosphorylation and inactivation (By similarity). Plays a role in RUFY3-mediated facilitating gastric cancer cells migration and invasion (PubMed:25766321). In response to DNA damage, phosphorylates MORC2 which activates its ATPase activity and facilitates chromatin remodeling (PubMed:23260667). In neurons, plays a crucial role in regulating GABA(A) receptor synaptic stability and hence GABAergic inhibitory synaptic transmission through its role in F-actin stabilization (By similarity). In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity). Along with GIT1, positively regulates microtubule nucleation during interphase (PubMed:27012601). Phosphorylates FXR1, promoting its localization to stress granules and activity (PubMed:20417602). Phosphorylates ILK on 'Thr-173' and 'Ser-246', promoting nuclear export of ILK (PubMed:17420447). {ECO:0000250|UniProtKB:O88643, ECO:0000250|UniProtKB:P35465, ECO:0000269|PubMed:10551809, ECO:0000269|PubMed:11733498, ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:12624090, ECO:0000269|PubMed:12876277, ECO:0000269|PubMed:14585966, ECO:0000269|PubMed:15611088, ECO:0000269|PubMed:15831477, ECO:0000269|PubMed:15833848, ECO:0000269|PubMed:17420447, ECO:0000269|PubMed:17726028, ECO:0000269|PubMed:17989089, ECO:0000269|PubMed:20417602, ECO:0000269|PubMed:22669945, ECO:0000269|PubMed:23260667, ECO:0000269|PubMed:23633677, ECO:0000269|PubMed:25766321, ECO:0000269|PubMed:27012601, ECO:0000269|PubMed:30290153, ECO:0000269|PubMed:8805275, ECO:0000269|PubMed:9032240, ECO:0000269|PubMed:9395435, ECO:0000269|PubMed:9528787}. |
| Q13177 | PAK2 | S192 | ochoa|psp | Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (Gamma-PAK) (PAK65) (S6/H4 kinase) (p21-activated kinase 2) (PAK-2) (p58) [Cleaved into: PAK-2p27 (p27); PAK-2p34 (p34) (C-t-PAK2)] | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation (PubMed:12853446, PubMed:16617111, PubMed:19273597, PubMed:19923322, PubMed:33693784, PubMed:7744004, PubMed:9171063). Acts as a downstream effector of the small GTPases CDC42 and RAC1 (PubMed:7744004). Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues (PubMed:7744004). Full-length PAK2 stimulates cell survival and cell growth (PubMed:7744004). Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration (PubMed:21317288). Phosphorylates JUN and plays an important role in EGF-induced cell proliferation (PubMed:21177766). Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP (PubMed:21724829). Phosphorylates CASP7, thereby preventing its activity (PubMed:21555521, PubMed:27889207). Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis (PubMed:19273597, PubMed:19923322). On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway (PubMed:12853446, PubMed:16617111, PubMed:9171063). Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation (PubMed:15234964). {ECO:0000269|PubMed:12853446, ECO:0000269|PubMed:15234964, ECO:0000269|PubMed:16617111, ECO:0000269|PubMed:19273597, ECO:0000269|PubMed:19923322, ECO:0000269|PubMed:21177766, ECO:0000269|PubMed:21317288, ECO:0000269|PubMed:21555521, ECO:0000269|PubMed:21724829, ECO:0000269|PubMed:27889207, ECO:0000269|PubMed:33693784, ECO:0000269|PubMed:7744004, ECO:0000269|PubMed:9171063}. |
| Q13421 | MSLN | S200 | ochoa | Mesothelin (CAK1 antigen) (Pre-pro-megakaryocyte-potentiating factor) [Cleaved into: Megakaryocyte-potentiating factor (MPF); Mesothelin, cleaved form] | Membrane-anchored forms may play a role in cellular adhesion.; FUNCTION: Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro. |
| Q13443 | ADAM9 | S799 | ochoa | Disintegrin and metalloproteinase domain-containing protein 9 (ADAM 9) (EC 3.4.24.-) (Cellular disintegrin-related protein) (Meltrin-gamma) (Metalloprotease/disintegrin/cysteine-rich protein 9) (Myeloma cell metalloproteinase) | Metalloprotease that cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5. May mediate cell-cell, cell-matrix interactions and regulate the motility of cells via interactions with integrins. {ECO:0000250|UniProtKB:Q61072}.; FUNCTION: [Isoform 2]: May act as alpha-secretase for amyloid precursor protein (APP). {ECO:0000269|PubMed:12054541}. |
| Q13480 | GAB1 | S257 | ochoa | GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1) | Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway (PubMed:29408807). {ECO:0000269|PubMed:29408807}. |
| Q13501 | SQSTM1 | S399 | ochoa | Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (p62) | Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes (PubMed:15340068, PubMed:15953362, PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22017874, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:33509017, PubMed:34471133, PubMed:34893540, PubMed:35831301, PubMed:37306101, PubMed:37802024). Promotes the recruitment of ubiquitinated cargo proteins to autophagosomes via multiple domains that bridge proteins and organelles in different steps (PubMed:16286508, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:34893540, PubMed:37802024). SQSTM1 first mediates the assembly and removal of ubiquitinated proteins by undergoing liquid-liquid phase separation upon binding to ubiquitinated proteins via its UBA domain, leading to the formation of insoluble cytoplasmic inclusions, known as p62 bodies (PubMed:15911346, PubMed:20168092, PubMed:22017874, PubMed:24128730, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:37802024). SQSTM1 then interacts with ATG8 family proteins on autophagosomes via its LIR motif, leading to p62 body recruitment to autophagosomes, followed by autophagic clearance of ubiquitinated proteins (PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:37802024). SQSTM1 is itself degraded along with its ubiquitinated cargos (PubMed:16286508, PubMed:17580304, PubMed:37802024). Also required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes (PubMed:26344566). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex by sequestering the complex in inclusion bodies, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357, PubMed:33393215, PubMed:37306101). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102, PubMed:33472082). Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation (PubMed:25101860). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 (PubMed:10356400, PubMed:10747026, PubMed:11244088, PubMed:12471037, PubMed:16079148, PubMed:19931284). May play a role in titin/TTN downstream signaling in muscle cells (PubMed:15802564). Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). {ECO:0000250|UniProtKB:Q64337, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10747026, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:12471037, ECO:0000269|PubMed:15340068, ECO:0000269|PubMed:15802564, ECO:0000269|PubMed:15911346, ECO:0000269|PubMed:15953362, ECO:0000269|PubMed:16079148, ECO:0000269|PubMed:16286508, ECO:0000269|PubMed:17580304, ECO:0000269|PubMed:19931284, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:22017874, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:25101860, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:28380357, ECO:0000269|PubMed:28404643, ECO:0000269|PubMed:29343546, ECO:0000269|PubMed:29496741, ECO:0000269|PubMed:29507397, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:33393215, ECO:0000269|PubMed:33472082, ECO:0000269|PubMed:33509017, ECO:0000269|PubMed:34471133, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:35831301, ECO:0000269|PubMed:37306101, ECO:0000269|PubMed:37802024}. |
| Q13542 | EIF4EBP2 | S25 | ochoa | Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2) | Repressor of translation initiation involved in synaptic plasticity, learning and memory formation (PubMed:30765518). Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (PubMed:25533957, PubMed:30765518). EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (By similarity). {ECO:0000250|UniProtKB:P70445, ECO:0000269|PubMed:25533957, ECO:0000269|PubMed:30765518}. |
| Q13542 | EIF4EBP2 | S83 | ochoa | Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2) | Repressor of translation initiation involved in synaptic plasticity, learning and memory formation (PubMed:30765518). Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (PubMed:25533957, PubMed:30765518). EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (By similarity). {ECO:0000250|UniProtKB:P70445, ECO:0000269|PubMed:25533957, ECO:0000269|PubMed:30765518}. |
| Q14315 | FLNC | S2152 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q14676 | MDC1 | S1132 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | S1583 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14686 | NCOA6 | S926 | ochoa | Nuclear receptor coactivator 6 (Activating signal cointegrator 2) (ASC-2) (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Nuclear receptor-activating protein, 250 kDa) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Thyroid hormone receptor-binding protein) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins. |
| Q15678 | PTPN14 | S760 | ochoa | Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez) | Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor. {ECO:0000269|PubMed:10934049, ECO:0000269|PubMed:12808048, ECO:0000269|PubMed:17893246, ECO:0000269|PubMed:20826270, ECO:0000269|PubMed:22233626, ECO:0000269|PubMed:22525271, ECO:0000269|PubMed:22948661}. |
| Q15742 | NAB2 | S189 | ochoa | NGFI-A-binding protein 2 (EGR-1-binding protein 2) (Melanoma-associated delayed early response protein) (Protein MADER) | Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity). {ECO:0000250}. |
| Q15746 | MYLK | S343 | ochoa|psp | Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Kinase-related protein) (KRP) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form] | Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessary for physiological and asthmatic airway resistance. Necessary for gastrointestinal motility. Implicated in the regulation of endothelial as well as vascular permeability, probably via the regulation of cytoskeletal rearrangements. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. Critical participant in signaling sequences that result in fibroblast apoptosis. Plays a role in the regulation of epithelial cell survival. Required for epithelial wound healing, especially during actomyosin ring contraction during purse-string wound closure. Mediates RhoA-dependent membrane blebbing. Triggers TRPC5 channel activity in a calcium-dependent signaling, by inducing its subcellular localization at the plasma membrane. Promotes cell migration (including tumor cells) and tumor metastasis. PTK2B/PYK2 activation by phosphorylation mediates ITGB2 activation and is thus essential to trigger neutrophil transmigration during acute lung injury (ALI). May regulate optic nerve head astrocyte migration. Probably involved in mitotic cytoskeletal regulation. Regulates tight junction probably by modulating ZO-1 exchange in the perijunctional actomyosin ring. Mediates burn-induced microvascular barrier injury; triggers endothelial contraction in the development of microvascular hyperpermeability by phosphorylating MLC. Essential for intestinal barrier dysfunction. Mediates Giardia spp.-mediated reduced epithelial barrier function during giardiasis intestinal infection via reorganization of cytoskeletal F-actin and tight junctional ZO-1. Necessary for hypotonicity-induced Ca(2+) entry and subsequent activation of volume-sensitive organic osmolyte/anion channels (VSOAC) in cervical cancer cells. Responsible for high proliferative ability of breast cancer cells through anti-apoptosis. {ECO:0000269|PubMed:11113114, ECO:0000269|PubMed:11976941, ECO:0000269|PubMed:15020676, ECO:0000269|PubMed:15825080, ECO:0000269|PubMed:16284075, ECO:0000269|PubMed:16723733, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:18710790, ECO:0000269|PubMed:19826488, ECO:0000269|PubMed:20139351, ECO:0000269|PubMed:20181817, ECO:0000269|PubMed:20375339, ECO:0000269|PubMed:20453870}. |
| Q2TAZ0 | ATG2A | S866 | ochoa | Autophagy-related protein 2 homolog A | Lipid transfer protein involved in autophagosome assembly (PubMed:28561066, PubMed:30952800, PubMed:31271352). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (PubMed:30952800, PubMed:31271352). Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion (PubMed:30952800, PubMed:31271352). Lipid transfer activity is enhanced by WIPI1 and WDR45/WIPI4, which promote ATG2A-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PubMed:31271352). Also regulates lipid droplets morphology and distribution within the cell (PubMed:22219374, PubMed:28561066). {ECO:0000269|PubMed:22219374, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:30952800, ECO:0000269|PubMed:31271352}. |
| Q3KQU3 | MAP7D1 | S366 | ochoa | MAP7 domain-containing protein 1 (Arginine/proline-rich coiled-coil domain-containing protein 1) (Proline/arginine-rich coiled-coil domain-containing protein 1) | Microtubule-stabilizing protein involved in the control of cell motility and neurite outgrowth. Facilitate microtubule stabilization through the maintenance of acetylated stable microtubules. {ECO:0000250|UniProtKB:A2AJI0}. |
| Q3T8J9 | GON4L | S198 | ochoa | GON-4-like protein (GON-4 homolog) | Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A and HDAC1. Required for B cell lymphopoiesis. {ECO:0000250|UniProtKB:Q9DB00}. |
| Q3V6T2 | CCDC88A | S245 | ochoa | Girdin (Akt phosphorylation enhancer) (APE) (Coiled-coil domain-containing protein 88A) (G alpha-interacting vesicle-associated protein) (GIV) (Girders of actin filament) (Hook-related protein 1) (HkRP1) | Bifunctional modulator of guanine nucleotide-binding proteins (G proteins) (PubMed:19211784, PubMed:27621449). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein G(i) alpha subunits (PubMed:19211784, PubMed:21954290, PubMed:23509302, PubMed:25187647). Also acts as a guanine nucleotide dissociation inhibitor for guanine nucleotide-binding protein G(s) subunit alpha GNAS (PubMed:27621449). Essential for cell migration (PubMed:16139227, PubMed:19211784, PubMed:20462955, PubMed:21954290). Interacts in complex with G(i) alpha subunits with the EGFR receptor, retaining EGFR at the cell membrane following ligand stimulation and promoting EGFR signaling which triggers cell migration (PubMed:20462955). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex which enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB (PubMed:19211784). Phosphorylation of AKT1/PKB induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Binds in its tyrosine-phosphorylated form to the phosphatidylinositol 3-kinase (PI3K) regulatory subunit PIK3R1 which enables recruitment of PIK3R1 to the EGFR receptor, enhancing PI3K activity and cell migration (PubMed:21954290). Plays a role as a key modulator of the AKT-mTOR signaling pathway, controlling the tempo of the process of newborn neuron integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Inhibition of G(s) subunit alpha GNAS leads to reduced cellular levels of cAMP and suppression of cell proliferation (PubMed:27621449). Essential for the integrity of the actin cytoskeleton (PubMed:16139227, PubMed:19211784). Required for formation of actin stress fibers and lamellipodia (PubMed:15882442). May be involved in membrane sorting in the early endosome (PubMed:15882442). Plays a role in ciliogenesis and cilium morphology and positioning and this may partly be through regulation of the localization of scaffolding protein CROCC/Rootletin (PubMed:27623382). {ECO:0000250|UniProtKB:Q5SNZ0, ECO:0000269|PubMed:15882442, ECO:0000269|PubMed:16139227, ECO:0000269|PubMed:19211784, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:21954290, ECO:0000269|PubMed:23509302, ECO:0000269|PubMed:25187647, ECO:0000269|PubMed:27621449, ECO:0000269|PubMed:27623382}. |
| Q5SY16 | NOL9 | S106 | ochoa | Polynucleotide 5'-hydroxyl-kinase NOL9 (EC 2.7.1.78) (Nucleolar protein 9) | Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of single-stranded and double-stranded RNA and DNA substrates (PubMed:21063389). Involved in rRNA processing and its kinase activity is required for the processing of the 32S precursor into 5.8S and 28S rRNAs, more specifically for the generation of the major 5.8S(S) form (PubMed:21063389). Required for the efficient pre-rRNA processing of internal transcribed spacer 2 (ITS2) (PubMed:21063389). Associates with LAS1L to form an ITS2 pre-rRNA endonuclease-kinase complex and is responsible for the transport of this complex into the nucleolus (PubMed:31288032). {ECO:0000269|PubMed:21063389, ECO:0000269|PubMed:31288032}. |
| Q5T0W9 | FAM83B | S875 | ochoa | Protein FAM83B | Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades. {ECO:0000269|PubMed:22886302, ECO:0000269|PubMed:23676467, ECO:0000269|PubMed:23912460}. |
| Q5T1R4 | HIVEP3 | S2354 | ochoa | Transcription factor HIVEP3 (Human immunodeficiency virus type I enhancer-binding protein 3) (Kappa-B and V(D)J recombination signal sequences-binding protein) (Kappa-binding protein 1) (KBP-1) (Zinc finger protein ZAS3) | Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Also binds to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and pro-inflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation. {ECO:0000269|PubMed:11161801}. |
| Q5T5C0 | STXBP5 | S692 | ochoa | Syntaxin-binding protein 5 (Lethal(2) giant larvae protein homolog 3) (Tomosyn-1) | Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane. Competes with STXBP1 for STX1 binding (By similarity). {ECO:0000250}. |
| Q5TCZ1 | SH3PXD2A | S379 | ochoa | SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains) | Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells (PubMed:27789576). Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. {ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:15710328, ECO:0000269|PubMed:15710903, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497, ECO:0000269|PubMed:27789576}. |
| Q5TCZ1 | SH3PXD2A | S818 | ochoa | SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains) | Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells (PubMed:27789576). Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. {ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:15710328, ECO:0000269|PubMed:15710903, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497, ECO:0000269|PubMed:27789576}. |
| Q5VUB5 | FAM171A1 | S644 | ochoa | Protein FAM171A1 (Astroprincin) (APCN) | Involved in the regulation of the cytoskeletal dynamics, plays a role in actin stress fiber formation. {ECO:0000269|PubMed:30312582}. |
| Q5VYM1 | SPATA31G1 | S403 | ochoa | Spermatogenesis-associated protein 31G1 | Dispensable for normal development and fertility. {ECO:0000250|UniProtKB:Q3V0E1}. |
| Q63ZY3 | KANK2 | S246 | ochoa | KN motif and ankyrin repeat domain-containing protein 2 (Ankyrin repeat domain-containing protein 25) (Matrix-remodeling-associated protein 3) (SRC-1-interacting protein) (SIP) (SRC-interacting protein) (SRC1-interacting protein) | Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (PubMed:17476305). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (PubMed:22371500). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (PubMed:22371500). Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (PubMed:17996375, PubMed:25961457). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457). Through the Rho signaling pathway may also regulate cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q8BX02, ECO:0000269|PubMed:17476305, ECO:0000269|PubMed:17996375, ECO:0000269|PubMed:22371500, ECO:0000269|PubMed:24671081, ECO:0000269|PubMed:25961457}. |
| Q68CZ2 | TNS3 | S698 | ochoa | Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6) | May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex (PubMed:17643115). EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1 (PubMed:17643115). Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA (PubMed:26166433). Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration (PubMed:35687021). Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1 (PubMed:31905841). {ECO:0000250|UniProtKB:Q5SSZ5, ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:31905841, ECO:0000269|PubMed:35687021, ECO:0000305}. |
| Q6N022 | TENM4 | S196 | ochoa | Teneurin-4 (Ten-4) (Protein Odd Oz/ten-m homolog 4) (Tenascin-M4) (Ten-m4) (Teneurin transmembrane protein 4) | Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Plays a role in the establishment of the anterior-posterior axis during gastrulation. Regulates the differentiation and cellular process formation of oligodendrocytes and myelination of small-diameter axons in the central nervous system (CNS) (PubMed:26188006). Promotes activation of focal adhesion kinase. May function as a cellular signal transducer (By similarity). {ECO:0000250|UniProtKB:Q3UHK6, ECO:0000269|PubMed:26188006}. |
| Q6P1L5 | FAM117B | S388 | ochoa | Protein FAM117B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 13 protein) | None |
| Q6P5W5 | SLC39A4 | S469 | ochoa | Zinc transporter ZIP4 (Solute carrier family 39 member 4) (Zrt- and Irt-like protein 4) (ZIP-4) | Selective transporter that mediates the uptake of Zn(2+) (PubMed:17202136, PubMed:22242765, PubMed:27321477, PubMed:28875161, PubMed:31164399, PubMed:31914589, PubMed:31979155, PubMed:33837739, PubMed:36473915). Plays an essential role for dietary zinc uptake from small intestine (By similarity). The Zn(2+) uniporter activity is regulated by zinc availability (PubMed:17202136, PubMed:32348750). Also exhibits polyspecific binding and transport of Cu(2+), Cd(2+) and possibly Ni(2+) but at higher concentrations (PubMed:22242765, PubMed:31914589). {ECO:0000250|UniProtKB:Q78IQ7, ECO:0000269|PubMed:17202136, ECO:0000269|PubMed:22242765, ECO:0000269|PubMed:27321477, ECO:0000269|PubMed:28875161, ECO:0000269|PubMed:31164399, ECO:0000269|PubMed:31914589, ECO:0000269|PubMed:31979155, ECO:0000269|PubMed:32348750, ECO:0000269|PubMed:33837739, ECO:0000269|PubMed:36473915}. |
| Q75N03 | CBLL1 | S278 | ochoa | E3 ubiquitin-protein ligase Hakai (EC 2.3.2.27) (Casitas B-lineage lymphoma-transforming sequence-like protein 1) (c-Cbl-like protein 1) (RING finger protein 188) (RING-type E3 ubiquitin transferase Hakai) | E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1 (By similarity). Targets CDH1 for endocytosis and degradation (By similarity). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Its function in the WMM complex is unknown (PubMed:29507755). {ECO:0000250|UniProtKB:Q9JIY2, ECO:0000269|PubMed:29507755}. |
| Q7L1V2 | MON1B | S71 | ochoa | Vacuolar fusion protein MON1 homolog B (HSV-1 stimulation-related gene 1 protein) (HSV-I stimulating-related protein) | None |
| Q7RTP6 | MICAL3 | S1512 | ochoa | [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3) | Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. {ECO:0000269|PubMed:21596566, ECO:0000269|PubMed:24440334}. |
| Q7Z434 | MAVS | S157 | ochoa | Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA) | Adapter required for innate immune defense against viruses (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:21170385, PubMed:23087404, PubMed:27992402, PubMed:33139700, PubMed:37582970). Acts downstream of DHX33, RIGI and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFNB and RANTES (CCL5) (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:20628368, PubMed:21170385, PubMed:23087404, PubMed:25636800, PubMed:27736772, PubMed:33110251). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state (PubMed:20451243). Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response (PubMed:20451243). May activate the same pathways following detection of extracellular dsRNA by TLR3 (PubMed:16153868). May protect cells from apoptosis (PubMed:16125763). Involved in NLRP3 inflammasome activation by mediating NLRP3 recruitment to mitochondria (PubMed:23582325). {ECO:0000269|PubMed:16125763, ECO:0000269|PubMed:16127453, ECO:0000269|PubMed:16153868, ECO:0000269|PubMed:16177806, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20451243, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:23087404, ECO:0000269|PubMed:23582325, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:27992402, ECO:0000269|PubMed:33110251, ECO:0000269|PubMed:33139700, ECO:0000269|PubMed:37582970}. |
| Q7Z6G8 | ANKS1B | S1223 | ochoa | Ankyrin repeat and sterile alpha motif domain-containing protein 1B (Amyloid-beta protein intracellular domain-associated protein 1) (AIDA-1) (E2A-PBX1-associated protein) (EB-1) | Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells.; FUNCTION: Isoform 3 can regulate global protein synthesis by altering nucleolar numbers. {ECO:0000250, ECO:0000269|PubMed:15347684, ECO:0000269|PubMed:15862129}.; FUNCTION: Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing. |
| Q86UU1 | PHLDB1 | S290 | ochoa | Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha) | None |
| Q86XN8 | MEX3D | S592 | ochoa | RNA-binding protein MEX3D (RING finger and KH domain-containing protein 1) (RING finger protein 193) (TINO) | RNA binding protein, may be involved in post-transcriptional regulatory mechanisms. {ECO:0000250}. |
| Q86YW5 | TREML1 | S264 | ochoa | Trem-like transcript 1 protein (TLT-1) (Triggering receptor expressed on myeloid cells-like protein 1) | Cell surface receptor that may play a role in the innate and adaptive immune response. {ECO:0000269|PubMed:15128762}. |
| Q8N3A8 | PARP8 | S373 | ochoa | Protein mono-ADP-ribosyltransferase PARP8 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 16) (ARTD16) (Poly [ADP-ribose] polymerase 8) (PARP-8) | Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. {ECO:0000269|PubMed:25043379}. |
| Q8N3D4 | EHBP1L1 | S462 | ochoa | EH domain-binding protein 1-like protein 1 | May act as Rab effector protein and play a role in vesicle trafficking. {ECO:0000305|PubMed:27552051}. |
| Q8N3D4 | EHBP1L1 | S1273 | ochoa | EH domain-binding protein 1-like protein 1 | May act as Rab effector protein and play a role in vesicle trafficking. {ECO:0000305|PubMed:27552051}. |
| Q8N3L3 | TXLNB | S552 | ochoa | Beta-taxilin (Muscle-derived protein 77) (hMDP77) | Promotes motor nerve regeneration (By similarity). May be involved in intracellular vesicle traffic. {ECO:0000250}. |
| Q8N4C8 | MINK1 | S733 | ochoa | Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6) | Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking (PubMed:10708748, PubMed:16337592). Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons (By similarity). Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates TANC1 upon stimulation by RAP2A, MBP and SMAD1 (PubMed:18930710, PubMed:21690388). Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1 (By similarity). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000250|UniProtKB:F1LP90, ECO:0000250|UniProtKB:Q9JM52, ECO:0000269|PubMed:10708748, ECO:0000269|PubMed:16337592, ECO:0000269|PubMed:18930710, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}.; FUNCTION: Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration. |
| Q8N684 | CPSF7 | S314 | ochoa | Cleavage and polyadenylation specificity factor subunit 7 (Cleavage and polyadenylation specificity factor 59 kDa subunit) (CPSF 59 kDa subunit) (Cleavage factor Im complex 59 kDa subunit) (CFIm59) (Pre-mRNA cleavage factor Im 59 kDa subunit) | Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:17024186, PubMed:29276085, PubMed:8626397). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:17024186, PubMed:8626397). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF7 activates directly the mRNA 3'-processing machinery (PubMed:29276085). Binds to pA signals in RNA substrates (PubMed:17024186, PubMed:8626397). {ECO:0000269|PubMed:17024186, ECO:0000269|PubMed:20695905, ECO:0000269|PubMed:23187700, ECO:0000269|PubMed:29276085, ECO:0000269|PubMed:8626397}. |
| Q8NBR6 | MINDY2 | S26 | ochoa | Ubiquitin carboxyl-terminal hydrolase MINDY-2 (EC 3.4.19.12) (Deubiquitinating enzyme MINDY-2) (Protein FAM63B) | Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins (PubMed:27292798). Binds to polyubiquitin chains of different linkage types, including 'Lys-6', 'Lys-11', 'Lys-29', 'Lys-33', 'Lys-48' and 'Lys-63' (PubMed:28082312). May play a regulatory role at the level of protein turnover (PubMed:27292798). {ECO:0000269|PubMed:27292798, ECO:0000269|PubMed:28082312}. |
| Q8ND30 | PPFIBP2 | S441 | ochoa | Liprin-beta-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2) (PTPRF-interacting protein-binding protein 2) | May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A. {ECO:0000269|PubMed:9624153}. |
| Q8NEG4 | FAM83F | S101 | ochoa | Protein FAM83F | None |
| Q8NEM7 | SUPT20H | S508 | ochoa | Transcription factor SPT20 homolog (p38-interacting protein) (p38IP) | Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail (By similarity). Required for starvation-induced ATG9A trafficking during autophagy. {ECO:0000250, ECO:0000269|PubMed:19893488}. |
| Q8NHV4 | NEDD1 | S452 | ochoa | Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1) (NEDD-1) | Required for mitosis progression. Promotes the nucleation of microtubules from the spindle. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19509060}. |
| Q8TC05 | MDM1 | S637 | ochoa | Nuclear protein MDM1 | Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules (PubMed:26337392). {ECO:0000269|PubMed:26337392}. |
| Q8TCG2 | PI4K2B | S45 | ochoa | Phosphatidylinositol 4-kinase type 2-beta (EC 2.7.1.67) (Phosphatidylinositol 4-kinase type II-beta) (PI4KII-BETA) | Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell (PubMed:11923287, PubMed:12324459). This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments (PubMed:11923287, PubMed:12324459). The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3) (PubMed:11923287, PubMed:12324459). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking. {ECO:0000269|PubMed:11923287, ECO:0000269|PubMed:12324459}. |
| Q8TDM6 | DLG5 | S888 | ochoa | Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG) | Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). {ECO:0000250|UniProtKB:E9Q9R9, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:28169360}. |
| Q8TDM6 | DLG5 | S1164 | ochoa | Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG) | Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). {ECO:0000250|UniProtKB:E9Q9R9, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:28169360}. |
| Q8TDR0 | TRAF3IP1 | S476 | ochoa | TRAF3-interacting protein 1 (Interleukin-13 receptor alpha 1-binding protein 1) (Intraflagellar transport protein 54 homolog) (Microtubule-interacting protein associated with TRAF3) (MIP-T3) | Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules. Involved in kidney development and epithelial morphogenesis. Involved in the regulation of microtubule cytoskeleton organization. Is a negative regulator of microtubule stability, acting through the control of MAP4 levels (PubMed:26487268). Involved in ciliogenesis (By similarity). {ECO:0000250|UniProtKB:Q149C2, ECO:0000269|PubMed:10791955, ECO:0000269|PubMed:12812986, ECO:0000269|PubMed:12935900, ECO:0000269|PubMed:26487268}. |
| Q8WU20 | FRS2 | S161 | ochoa | Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (FGFR-signaling adaptor SNT) (Suc1-associated neurotrophic factor target 1) (SNT-1) | Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. {ECO:0000269|PubMed:12974390, ECO:0000269|PubMed:21765395}. |
| Q8WXD9 | CASKIN1 | S724 | ochoa | Caskin-1 (CASK-interacting protein 1) | May link the scaffolding protein CASK to downstream intracellular effectors. {ECO:0000250}. |
| Q8WYJ6 | SEPTIN1 | S312 | psp | Septin-1 (LARP) (Peanut-like protein 3) (Serologically defined breast cancer antigen NY-BR-24) | Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). {ECO:0000250, ECO:0000305}. |
| Q8WZ73 | RFFL | S226 | ochoa | E3 ubiquitin-protein ligase rififylin (EC 2.3.2.27) (Caspase regulator CARP2) (Caspases-8 and -10-associated RING finger protein 2) (CARP-2) (FYVE-RING finger protein Sakura) (Fring) (RING finger and FYVE-like domain-containing protein 1) (RING finger protein 189) (RING finger protein 34-like) (RING-type E3 ubiquitin transferase rififylin) | E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. Negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. May also play a role in endocytic recycling. {ECO:0000269|PubMed:15069192, ECO:0000269|PubMed:17121812, ECO:0000269|PubMed:18382127, ECO:0000269|PubMed:18450452, ECO:0000269|PubMed:22609986}. |
| Q92558 | WASF1 | S299 | ochoa | Actin-binding protein WASF1 (Protein WAVE-1) (Verprolin homology domain-containing protein 1) (Wiskott-Aldrich syndrome protein family member 1) (WASP family protein member 1) | Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation (PubMed:29961568). The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity). As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). Also involved in the regulation of mitochondrial dynamics (PubMed:29961568). {ECO:0000250|UniProtKB:Q8R5H6, ECO:0000269|PubMed:29961568, ECO:0000269|PubMed:9889097}. |
| Q92625 | ANKS1A | S331 | ochoa | Ankyrin repeat and SAM domain-containing protein 1A (Odin) | Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity). {ECO:0000250, ECO:0000269|PubMed:17875921}. |
| Q969G9 | NKD1 | S317 | ochoa | Protein naked cuticle homolog 1 (Naked-1) (hNkd) (hNkd1) | Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity. {ECO:0000269|PubMed:11752446, ECO:0000269|PubMed:15687260, ECO:0000269|PubMed:16567647}. |
| Q96D71 | REPS1 | S709 | ochoa|psp | RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1) | May coordinate the cellular actions of activated EGF receptors and Ral-GTPases. {ECO:0000250}. |
| Q96FS4 | SIPA1 | S873 | ochoa | Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase-activating protein Spa-1) (p130 SPA-1) | GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state (PubMed:9346962). Affects cell cycle progression (By similarity). {ECO:0000250|UniProtKB:P46062, ECO:0000269|PubMed:9346962}. |
| Q96JB2 | COG3 | S663 | ochoa | Conserved oligomeric Golgi complex subunit 3 (COG complex subunit 3) (Component of oligomeric Golgi complex 3) (Vesicle-docking protein SEC34 homolog) (p94) | Involved in ER-Golgi transport (PubMed:11929878). Also involved in retrograde (Golgi to ER) transport (PubMed:37711075). {ECO:0000269|PubMed:11929878, ECO:0000269|PubMed:37711075}. |
| Q96PN7 | TRERF1 | S678 | ochoa | Transcriptional-regulating factor 1 (Breast cancer anti-estrogen resistance 2) (Transcriptional-regulating protein 132) (Zinc finger protein rapa) (Zinc finger transcription factor TReP-132) | Binds DNA and activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1. {ECO:0000269|PubMed:11349124, ECO:0000269|PubMed:16371131}. |
| Q96RT1 | ERBIN | S1133 | ochoa | Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2) | Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). {ECO:0000269|PubMed:10878805, ECO:0000269|PubMed:16203728}. |
| Q96RT7 | TUBGCP6 | S1304 | ochoa | Gamma-tubulin complex component 6 (GCP-6) | Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:11694571, PubMed:38305685, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685, PubMed:38609661, PubMed:39321809). {ECO:0000269|PubMed:11694571, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| Q96RY5 | CRAMP1 | S1187 | ochoa | Protein cramped-like (Cramped chromatin regulator homolog 1) (Hematological and neurological expressed 1-like protein) | None |
| Q99941 | ATF6B | S564 | ochoa | Cyclic AMP-dependent transcription factor ATF-6 beta (cAMP-dependent transcription factor ATF-6 beta) (Activating transcription factor 6 beta) (ATF6-beta) (Protein G13) (cAMP response element-binding protein-related protein) (Creb-rp) (cAMP-responsive element-binding protein-like 1) [Cleaved into: Processed cyclic AMP-dependent transcription factor ATF-6 beta] | [Cyclic AMP-dependent transcription factor ATF-6 beta]: Precursor of the transcription factor form (Processed cyclic AMP-dependent transcription factor ATF-6 beta), which is embedded in the endoplasmic reticulum membrane (PubMed:11256944). Endoplasmic reticulum stress promotes processing of this form, releasing the transcription factor form that translocates into the nucleus, where it activates transcription of genes involved in the unfolded protein response (UPR) (PubMed:11256944). {ECO:0000269|PubMed:11256944}.; FUNCTION: [Processed cyclic AMP-dependent transcription factor ATF-6 beta]: Transcription factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress (PubMed:11256944). Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAATN(9)CCAC[GA]-3') when NF-Y is bound to ERSE (PubMed:11256944). {ECO:0000269|PubMed:11256944}. |
| Q99959 | PKP2 | S251 | ochoa | Plakophilin-2 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:25208567). Regulates focal adhesion turnover resulting in changes in focal adhesion size, cell adhesion and cell spreading, potentially via transcriptional modulation of beta-integrins (PubMed:23884246). Required to maintain gingival epithelial barrier function (PubMed:34368962). Important component of the desmosome that is also required for localization of desmosome component proteins such as DSC2, DSG2 and JUP to the desmosome cell-cell junction (PubMed:22781308, PubMed:25208567). Required for the formation of desmosome cell junctions in cardiomyocytes, thereby required for the correct formation of the heart, specifically trabeculation and formation of the atria walls (By similarity). Loss of desmosome cell junctions leads to mis-localization of DSP and DSG2 resulting in disruption of cell-cell adhesion and disordered intermediate filaments (By similarity). Modulates profibrotic gene expression in cardiomyocytes via regulation of DSP expression and subsequent activation of downstream TGFB1 and MAPK14/p38 MAPK signaling (By similarity). Required for cardiac sodium current propagation and electrical synchrony in cardiac myocytes, via ANK3 stabilization and modulation of SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). Required for mitochondrial function, nuclear envelope integrity and positive regulation of SIRT3 transcription via maintaining DES localization at its nuclear envelope and cell tip anchoring points, and thereby preserving regulation of the transcriptional program (PubMed:35959657). Maintenance of nuclear envelope integrity protects against DNA damage and transcriptional dysregulation of genes, especially those involved in the electron transport chain, thereby preserving mitochondrial function and protecting against superoxide radical anion generation (PubMed:35959657). Binds single-stranded DNA (ssDNA) (PubMed:20613778). May regulate the localization of GJA1 to gap junctions in intercalated disks of the heart (PubMed:18662195). Involved in the inhibition of viral infection by influenza A viruses (IAV) (PubMed:28169297). Acts as a host restriction factor for IAV viral propagation, potentially via disrupting the interaction of IAV polymerase complex proteins (PubMed:28169297). {ECO:0000250|UniProtKB:F1M7L9, ECO:0000250|UniProtKB:Q9CQ73, ECO:0000269|PubMed:18662195, ECO:0000269|PubMed:20613778, ECO:0000269|PubMed:22781308, ECO:0000269|PubMed:23884246, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:28169297, ECO:0000269|PubMed:34368962, ECO:0000269|PubMed:35959657}. |
| Q9BQK8 | LPIN3 | S347 | ochoa | Phosphatidate phosphatase LPIN3 (EC 3.1.3.4) (Lipin-3) (Lipin-3-like) | Magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis therefore regulates fatty acid metabolism. {ECO:0000250|UniProtKB:Q99PI4}. |
| Q9BSW7 | SYT17 | S66 | ochoa | Synaptotagmin-17 (Protein B/K) (Synaptotagmin XVII) (SytXVII) | Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000269|PubMed:23999003}. |
| Q9BW04 | SARG | S309 | ochoa | Specifically androgen-regulated gene protein | Putative androgen-specific receptor. {ECO:0000269|PubMed:15525603}. |
| Q9BZ71 | PITPNM3 | S946 | ochoa | Membrane-associated phosphatidylinositol transfer protein 3 (Phosphatidylinositol transfer protein, membrane-associated 3) (PITPnm 3) (Pyk2 N-terminal domain-interacting receptor 1) (NIR-1) | Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro) (By similarity). Binds calcium ions. {ECO:0000250}. |
| Q9C0C2 | TNKS1BP1 | S178 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9C0C2 | TNKS1BP1 | S1516 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9H400 | LIME1 | S256 | ochoa | Lck-interacting transmembrane adapter 1 (Lck-interacting membrane protein) (Lck-interacting molecule) | Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T-cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules. {ECO:0000269|PubMed:14610046}. |
| Q9H5I5 | PIEZO2 | S1836 | ochoa | Piezo-type mechanosensitive ion channel component 2 (Protein FAM38B) | Pore-forming subunit of the mechanosensitive non-specific cation Piezo channel required for rapidly adapting mechanically activated (MA) currents and has a key role in sensing touch and tactile pain (PubMed:37590348). Piezo channels are homotrimeric three-blade propeller-shaped structures that utilize a cap-motion and plug-and-latch mechanism to gate their ion-conducting pathways (PubMed:37590348). Expressed in sensory neurons, is essential for diverse physiological processes, including respiratory control, systemic metabolism, urinary function, and proprioception (By similarity). Mediates airway stretch sensing, enabling efficient respiration at birth and maintaining normal breathing in adults (By similarity). It regulates brown and beige adipose tissue morphology and function, preventing systemic hypermetabolism (By similarity). In the lower urinary tract, acts as a sensor in both the bladder urothelium and innervating sensory neurons being required for bladder-stretch sensing and urethral micturition reflexes, ensuring proper urinary function (PubMed:33057202). Additionally, PIEZO2 serves as the principal mechanotransducer in proprioceptors, facilitating proprioception and coordinated body movements (By similarity). In inner ear hair cells, PIEZO1/2 subunits may constitute part of the mechanotransducer (MET) non-selective cation channel complex where they may act as pore-forming ion-conducting component in the complex (By similarity). Required for Merkel-cell mechanotransduction (By similarity). Plays a major role in light-touch mechanosensation (By similarity). {ECO:0000250|UniProtKB:Q8CD54, ECO:0000269|PubMed:33057202, ECO:0000269|PubMed:37590348}. |
| Q9H792 | PEAK1 | S792 | ochoa | Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269) | Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:20534451, PubMed:23105102, PubMed:35687021). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654). {ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:23105102, ECO:0000269|PubMed:23846654, ECO:0000269|PubMed:35687021}. |
| Q9H7F0 | ATP13A3 | S817 | ochoa | Polyamine-transporting ATPase 13A3 (ATPase family homolog up-regulated in senescence cells 1) (Putrescine transporting ATPase) (EC 7.6.2.16) | ATP-driven pump involved in endocytosis-dependent polyamine transport. Uses ATP as an energy source to transfer polyamine precursor putrescine from the endosomal compartment to the cytosol. {ECO:0000269|PubMed:27429841, ECO:0000269|PubMed:33310703}. |
| Q9H8V3 | ECT2 | S412 | ochoa | Protein ECT2 (Epithelial cell-transforming sequence 2 oncogene) | Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. {ECO:0000269|PubMed:10579713, ECO:0000269|PubMed:14645260, ECO:0000269|PubMed:15254234, ECO:0000269|PubMed:15545273, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16170345, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:16495035, ECO:0000269|PubMed:19129481, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19617897, ECO:0000269|PubMed:21189248, ECO:0000269|PubMed:21373644, ECO:0000269|PubMed:25068414, ECO:0000269|PubMed:31888991}. |
| Q9NQC1 | JADE2 | S119 | ochoa | E3 ubiquitin-protein ligase Jade-2 (EC 2.3.2.27) (Jade family PHD finger protein 2) (PHD finger protein 15) | Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity (PubMed:16387653). Acts as an E3 ubiquitin-protein ligase mediating the ubiquitination and subsequent proteasomal degradation of target protein histone demethylase KDM1A (PubMed:25018020). Also acts as a ubiquitin ligase E3 toward itself. Positive regulator of neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q6ZQF7, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:25018020}. |
| Q9NQV6 | PRDM10 | S803 | ochoa | PR domain zinc finger protein 10 (PR domain-containing protein 10) (Tristanin) | Transcriptional activator, essential for early embryonic development and survival of embryonic stem cells (ESCs) (By similarity). Supports cell growth and survival during early development by transcriptionally activating the expression of the translation initiation factor EIF3B, to sustain global translation (By similarity). Activates the transcription of FLNC (PubMed:36440963). {ECO:0000250|UniProtKB:Q3UTQ7, ECO:0000269|PubMed:36440963}. |
| Q9NR33 | POLE4 | S25 | ochoa | DNA polymerase epsilon subunit 4 (DNA polymerase II subunit 4) (DNA polymerase epsilon subunit p12) | Accessory component of the DNA polymerase epsilon complex (PubMed:10801849). Participates in DNA repair and in chromosomal DNA replication (By similarity). {ECO:0000250|UniProtKB:P27344, ECO:0000269|PubMed:10801849}. |
| Q9NRA8 | EIF4ENIF1 | S577 | ochoa | Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) | EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}. |
| Q9NVW2 | RLIM | S195 | ochoa | E3 ubiquitin-protein ligase RLIM (EC 2.3.2.27) (LIM domain-interacting RING finger protein) (RING finger LIM domain-binding protein) (R-LIM) (RING finger protein 12) (RING-type E3 ubiquitin transferase RLIM) (Renal carcinoma antigen NY-REN-43) | E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals. {ECO:0000269|PubMed:19164295, ECO:0000269|PubMed:19945382}. |
| Q9NX94 | WBP1L | S199 | ochoa | WW domain binding protein 1-like (Outcome predictor in acute leukemia 1) | None |
| Q9NXH8 | TOR4A | S81 | ochoa | Torsin-4A (Torsin family 4 member A) | None |
| Q9NXH8 | TOR4A | S97 | ochoa | Torsin-4A (Torsin family 4 member A) | None |
| Q9P0L2 | MARK1 | S556 | ochoa | Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (EC 2.7.11.26) (MAP/microtubule affinity-regulating kinase 1) (PAR1 homolog c) (Par-1c) (Par1c) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:17573348, ECO:0000269|PubMed:23666762}. |
| Q9P1Y6 | PHRF1 | S850 | ochoa | PHD and RING finger domain-containing protein 1 | None |
| Q9P227 | ARHGAP23 | S1351 | ochoa | Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| Q9P241 | ATP10D | S520 | ochoa | Phospholipid-transporting ATPase VD (EC 7.6.2.1) (ATPase class V type 10D) (P4-ATPase flippase complex alpha subunit ATP10D) | Catalytic component of a P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of glucosylceramide (GlcCer) from the outer to the inner leaflet of the plasma membrane. {ECO:0000269|PubMed:30530492}. |
| Q9P242 | NYAP2 | S206 | ochoa | Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 | Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis. {ECO:0000250}. |
| Q9P266 | JCAD | S1010 | ochoa | Junctional cadherin 5-associated protein (Junctional protein associated with coronary artery disease) (JCAD) | None |
| Q9P2D1 | CHD7 | S559 | ochoa | Chromodomain-helicase-DNA-binding protein 7 (CHD-7) (EC 3.6.4.-) (ATP-dependent helicase CHD7) | ATP-dependent chromatin-remodeling factor, slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Probable transcription regulator. May be involved in the in 45S precursor rRNA production. {ECO:0000269|PubMed:22646239, ECO:0000269|PubMed:28533432}. |
| Q9P2F8 | SIPA1L2 | S1538 | ochoa | Signal-induced proliferation-associated 1-like protein 2 (SIPA1-like protein 2) | None |
| Q9UIF9 | BAZ2A | S1375 | ochoa | Bromodomain adjacent to zinc finger domain protein 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3) | Regulatory subunit of the ATP-dependent NoRC-1 and NoRC-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Directly stimulates the ATPase activity of SMARCA5 in the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). The NoRC-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NoRC-5 ISWI chromatin remodeling complex, mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription (By similarity). Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac (By similarity). Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity). {ECO:0000250|UniProtKB:Q91YE5, ECO:0000269|PubMed:28801535}. |
| Q9UIJ5 | ZDHHC2 | S331 | ochoa | Palmitoyltransferase ZDHHC2 (EC 2.3.1.225) (Acyltransferase ZDHHC2) (EC 2.3.1.-) (Reduced expression associated with metastasis protein) (Ream) (Reduced expression in cancer protein) (Rec) (Zinc finger DHHC domain-containing protein 2) (DHHC-2) (Zinc finger protein 372) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes (PubMed:18296695, PubMed:18508921, PubMed:19144824, PubMed:21343290, PubMed:22034844, PubMed:23793055). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). In the nervous system, plays a role in long term synaptic potentiation by palmitoylating AKAP5 through which it regulates protein trafficking from the dendritic recycling endosomes to the plasma membrane and controls both structural and functional plasticity at excitatory synapses (By similarity). In dendrites, mediates the palmitoylation of DLG4 when synaptic activity decreases and induces synaptic clustering of DLG4 and associated AMPA-type glutamate receptors (By similarity). Also mediates the de novo and turnover palmitoylation of RGS7BP, a shuttle for Gi/o-specific GTPase-activating proteins/GAPs, promoting its localization to the plasma membrane in response to the activation of G protein-coupled receptors. Through the localization of these GTPase-activating proteins/GAPs, it also probably plays a role in G protein-coupled receptors signaling in neurons (By similarity). Also probably plays a role in cell adhesion by palmitoylating CD9 and CD151 to regulate their expression and function (PubMed:18508921). Palmitoylates the endoplasmic reticulum protein CKAP4 and regulates its localization to the plasma membrane (PubMed:18296695, PubMed:19144824). Could also palmitoylate LCK and regulate its localization to the plasma membrane (PubMed:22034844). {ECO:0000250|UniProtKB:P59267, ECO:0000250|UniProtKB:Q9JKR5, ECO:0000269|PubMed:18296695, ECO:0000269|PubMed:18508921, ECO:0000269|PubMed:19144824, ECO:0000269|PubMed:21343290, ECO:0000269|PubMed:22034844, ECO:0000269|PubMed:23793055}.; FUNCTION: (Microbial infection) Promotes Chikungunya virus (CHIKV) replication by mediating viral nsp1 palmitoylation. {ECO:0000269|PubMed:30404808}. |
| Q9UKK3 | PARP4 | S1335 | ochoa | Protein mono-ADP-ribosyltransferase PARP4 (EC 2.4.2.-) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Poly [ADP-ribose] polymerase 4) (PARP-4) (Vault poly(ADP-ribose) polymerase) (VPARP) | Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. {ECO:0000269|PubMed:25043379}. |
| Q9ULL1 | PLEKHG1 | S876 | ochoa | Pleckstrin homology domain-containing family G member 1 | None |
| Q9ULL1 | PLEKHG1 | S1128 | ochoa | Pleckstrin homology domain-containing family G member 1 | None |
| Q9UMN6 | KMT2B | S1069 | ochoa | Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17707229, PubMed:25561738). Likely plays a redundant role with KMT2C in enriching H3K4me1 marks on primed and active enhancer elements (PubMed:24081332). Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 (PubMed:17707229). Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development (By similarity). Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation (By similarity). {ECO:0000250|UniProtKB:O08550, ECO:0000269|PubMed:17707229, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q9UMS6 | SYNPO2 | S804 | ochoa | Synaptopodin-2 (Genethonin-2) (Myopodin) | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. |
| Q9UPQ9 | TNRC6B | S1432 | ochoa | Trinucleotide repeat-containing gene 6B protein | Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs) (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). As scaffolding protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes (PubMed:21981923). {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:19167051, ECO:0000269|PubMed:19304925, ECO:0000269|PubMed:21981923, ECO:0000269|PubMed:32354837}. |
| Q9UPU9 | SAMD4A | S272 | ochoa | Protein Smaug homolog 1 (Smaug 1) (hSmaug1) (Sterile alpha motif domain-containing protein 4A) (SAM domain-containing protein 4A) | Acts as a translational repressor of SRE-containing messengers. {ECO:0000269|PubMed:16221671}. |
| Q9UQ84 | EXO1 | S746 | ochoa|psp | Exonuclease 1 (hExo1) (EC 3.1.-.-) (Exonuclease I) (hExoI) | 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis. {ECO:0000269|PubMed:10364235, ECO:0000269|PubMed:10608837, ECO:0000269|PubMed:11809771, ECO:0000269|PubMed:11842105, ECO:0000269|PubMed:12414623, ECO:0000269|PubMed:12704184, ECO:0000269|PubMed:14636568, ECO:0000269|PubMed:14676842, ECO:0000269|PubMed:15225546, ECO:0000269|PubMed:15886194, ECO:0000269|PubMed:16143102, ECO:0000269|PubMed:9685493}. |
| Q9UQQ2 | SH2B3 | S120 | ochoa | SH2B adapter protein 3 (Lymphocyte adapter protein) (Lymphocyte-specific adapter protein Lnk) (Signal transduction protein Lnk) | Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase. {ECO:0000250}. |
| Q9Y250 | LZTS1 | S209 | ochoa | Leucine zipper putative tumor suppressor 1 (F37/esophageal cancer-related gene-coding leucine-zipper motif) (Fez1) | Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor. {ECO:0000269|PubMed:10097140, ECO:0000269|PubMed:11464283, ECO:0000269|PubMed:11504921}. |
| Q9Y2K9 | STXBP5L | S766 | psp | Syntaxin-binding protein 5-like (Lethal(2) giant larvae protein homolog 4) (Tomosyn-2) | Plays a role in vesicle trafficking and exocytosis inhibition. In pancreatic beta-cells, inhibits insulin secretion probably by interacting with and regulating STX1A and STX4, key t-SNARE proteins involved in the fusion of insulin granules to the plasma membrane. Also plays a role in neurotransmitter release by inhibiting basal acetylcholine release from axon terminals and by preventing synaptic fatigue upon repetitive stimulation (By similarity). Promotes as well axonal outgrowth (PubMed:25504045). {ECO:0000250|UniProtKB:Q5DQR4, ECO:0000269|PubMed:25504045}. |
| Q9Y3R5 | DOP1B | S589 | ochoa | Protein DOP1B | May play a role in regulating membrane trafficking of cargo proteins. Together with ATP9A and MON2, regulates SNX3 retromer-mediated endosomal sorting of WLS away from lysosomal degradation. {ECO:0000269|PubMed:30213940}. |
| Q9Y3R5 | DOP1B | S1050 | ochoa | Protein DOP1B | May play a role in regulating membrane trafficking of cargo proteins. Together with ATP9A and MON2, regulates SNX3 retromer-mediated endosomal sorting of WLS away from lysosomal degradation. {ECO:0000269|PubMed:30213940}. |
| Q9Y446 | PKP3 | S123 | ochoa | Plakophilin-3 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:24124604). Required for the localization of DSG2, DSP and PKP2 to mature desmosome junctions (PubMed:20859650). May also play a role in the maintenance of DSG3 protein abundance in keratinocytes (By similarity). Required for the formation of DSP-containing desmosome precursors in the cytoplasm during desmosome assembly (PubMed:25208567). Also regulates the accumulation of CDH1 to mature desmosome junctions, via cAMP-dependent signaling and its interaction with activated RAP1A (PubMed:25208567). Positively regulates the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with FXR1, may also regulate the protein abundance of DSP via the same mechanism (PubMed:25225333). May also regulate the protein abundance of the desmosome component PKP1 (By similarity). Required for the organization of desmosome junctions at intercellular borders between basal keratinocytes of the epidermis, as a result plays a role in maintenance of the dermal barrier and regulation of the dermal inflammatory response (By similarity). Required during epidermal keratinocyte differentiation for cell adherence at tricellular cell-cell contacts, via regulation of the timely formation of adherens junctions and desmosomes in a calcium-dependent manner, and may also play a role in the organization of the intracellular actin fiber belt (By similarity). Acts as a negative regulator of the inflammatory response in hematopoietic cells of the skin and intestine, via modulation of proinflammatory cytokine production (By similarity). Important for epithelial barrier maintenance in the intestine to reduce intestinal permeability, thereby plays a role in protection from intestinal-derived endotoxemia (By similarity). Required for the development of hair follicles, via a role in the regulation of inner root sheaf length, correct alignment and anterior-posterior polarity of hair follicles (By similarity). Promotes proliferation and cell-cycle G1/S phase transition of keratinocytes (By similarity). Promotes E2F1-driven transcription of G1/S phase promoting genes by acting to release E2F1 from its inhibitory interaction with RB1, via sequestering RB1 and CDKN1A to the cytoplasm and thereby increasing CDK4- and CDK6-driven phosphorylation of RB1 (By similarity). May act as a scaffold protein to facilitate MAPK phosphorylation of RPS6KA protein family members and subsequently promote downstream EGFR signaling (By similarity). May play a role in the positive regulation of transcription of Wnt-mediated TCF-responsive target genes (PubMed:34058472). {ECO:0000250|UniProtKB:Q9QY23, ECO:0000269|PubMed:20859650, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:34058472}. |
| Q9Y450 | HBS1L | S205 | ochoa | HBS1-like protein (EC 3.6.5.-) (ERFS) | GTPase component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:21448132, PubMed:23667253, PubMed:27863242). The Pelota-HBS1L complex recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel (PubMed:27863242). Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (PubMed:21448132, PubMed:32006463). {ECO:0000269|PubMed:21448132, ECO:0000269|PubMed:23667253, ECO:0000269|PubMed:27863242, ECO:0000269|PubMed:32006463}. |
| Q9Y485 | DMXL1 | S1285 | ochoa | DmX-like protein 1 (X-like 1 protein) | None |
| Q9Y6X6 | MYO16 | S1362 | ochoa | Unconventional myosin-XVI (Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 3) (Unconventional myosin-16) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. May be involved in targeting of the catalytic subunit of protein phosphatase 1 during brain development. Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis (By similarity). {ECO:0000250}. |
| P27695 | APEX1 | S129 | Sugiyama | DNA repair nuclease/redox regulator APEX1 (EC 3.1.11.2) (EC 3.1.21.-) (APEX nuclease) (APEN) (Apurinic-apyrimidinic endonuclease 1) (AP endonuclease 1) (APE-1) (DNA-(apurinic or apyrimidinic site) endonuclease) (Redox factor-1) (REF-1) [Cleaved into: DNA repair nuclease/redox regulator APEX1, mitochondrial] | Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 are DNA repair and redox regulation of transcriptional factors (PubMed:11118054, PubMed:11452037, PubMed:15831793, PubMed:18439621, PubMed:18579163, PubMed:21762700, PubMed:24079850, PubMed:8355688, PubMed:9108029, PubMed:9560228). Functions as an apurinic/apyrimidinic (AP) endodeoxyribonuclease in the base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Also incises at AP sites in the DNA strand of DNA/RNA hybrids, single-stranded DNA regions of R-loop structures, and single-stranded RNA molecules (PubMed:15380100, PubMed:16617147, PubMed:18439621, PubMed:19123919, PubMed:19188445, PubMed:19934257, PubMed:20699270, PubMed:21762700, PubMed:24079850, PubMed:8932375, PubMed:8995436, PubMed:9804799). Operates at switch sites of immunoglobulin (Ig) constant regions where it mediates Ig isotype class switch recombination. Processes AP sites induced by successive action of AICDA and UNG. Generates staggered nicks in opposite DNA strands resulting in the formation of double-strand DNA breaks that are finally resolved via non-homologous end joining repair pathway (By similarity). Has 3'-5' exodeoxyribonuclease activity on mismatched deoxyribonucleotides at the 3' termini of nicked or gapped DNA molecules during short-patch BER (PubMed:11832948, PubMed:1719477). Possesses DNA 3' phosphodiesterase activity capable of removing lesions (such as phosphoglycolate and 8-oxoguanine) blocking the 3' side of DNA strand breaks (PubMed:15831793, PubMed:7516064). Also acts as an endoribonuclease involved in the control of single-stranded RNA metabolism. Plays a role in regulating MYC mRNA turnover by preferentially cleaving in between UA and CA dinucleotides of the MYC coding region determinant (CRD). In association with NMD1, plays a role in the rRNA quality control process during cell cycle progression (PubMed:19188445, PubMed:19401441, PubMed:21762700). Acts as a loading factor for POLB onto non-incised AP sites in DNA and stimulates the 5'-terminal deoxyribose 5'-phosphate (dRp) excision activity of POLB (PubMed:9207062). Exerts reversible nuclear redox activity to regulate DNA binding affinity and transcriptional activity of transcriptional factors by controlling the redox status of their DNA-binding domain, such as the FOS/JUN AP-1 complex after exposure to IR (PubMed:10023679, PubMed:11118054, PubMed:11452037, PubMed:18579163, PubMed:8355688, PubMed:9108029). Involved in calcium-dependent down-regulation of parathyroid hormone (PTH) expression by binding to negative calcium response elements (nCaREs). Together with HNRNPL or the dimer XRCC5/XRCC6, associates with nCaRE, acting as an activator of transcriptional repression (PubMed:11809897, PubMed:14633989, PubMed:8621488). May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (PubMed:21496894). Stimulates the YBX1-mediated MDR1 promoter activity, when acetylated at Lys-6 and Lys-7, leading to drug resistance (PubMed:18809583). Plays a role in protection from granzyme-mediated cellular repair leading to cell death (PubMed:18179823). Binds DNA and RNA. Associates, together with YBX1, on the MDR1 promoter. Together with NPM1, associates with rRNA (PubMed:19188445, PubMed:19401441, PubMed:20699270). {ECO:0000250|UniProtKB:P28352, ECO:0000269|PubMed:10023679, ECO:0000269|PubMed:11118054, ECO:0000269|PubMed:11452037, ECO:0000269|PubMed:11809897, ECO:0000269|PubMed:11832948, ECO:0000269|PubMed:12524539, ECO:0000269|PubMed:14633989, ECO:0000269|PubMed:15380100, ECO:0000269|PubMed:15831793, ECO:0000269|PubMed:16617147, ECO:0000269|PubMed:1719477, ECO:0000269|PubMed:18179823, ECO:0000269|PubMed:18439621, ECO:0000269|PubMed:18579163, ECO:0000269|PubMed:18809583, ECO:0000269|PubMed:19123919, ECO:0000269|PubMed:19188445, ECO:0000269|PubMed:19401441, ECO:0000269|PubMed:19934257, ECO:0000269|PubMed:20699270, ECO:0000269|PubMed:21496894, ECO:0000269|PubMed:21762700, ECO:0000269|PubMed:24079850, ECO:0000269|PubMed:7516064, ECO:0000269|PubMed:8355688, ECO:0000269|PubMed:8621488, ECO:0000269|PubMed:8932375, ECO:0000269|PubMed:8995436, ECO:0000269|PubMed:9108029, ECO:0000269|PubMed:9207062, ECO:0000269|PubMed:9560228, ECO:0000269|PubMed:9804799}. |
| O14965 | AURKA | S266 | GPS6|ELM|EPSD|PSP | Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Breast tumor-amplified kinase) (Ipl1- and aurora-related kinase 1) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase Ayk1) (Serine/threonine-protein kinase aurora-A) | Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression (PubMed:11039908, PubMed:12390251, PubMed:17125279, PubMed:17360485, PubMed:18615013, PubMed:26246606). Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis (PubMed:14523000, PubMed:26246606). Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (PubMed:27335426). Required for initial activation of CDK1 at centrosomes (PubMed:13678582, PubMed:15128871). Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2 (PubMed:11551964, PubMed:14702041, PubMed:15128871, PubMed:15147269, PubMed:15987997, PubMed:17604723, PubMed:18056443, PubMed:18615013). Phosphorylates MCRS1 which is required for MCRS1-mediated kinetochore fiber assembly and mitotic progression (PubMed:27192185). Regulates KIF2A tubulin depolymerase activity (PubMed:19351716). Important for microtubule formation and/or stabilization (PubMed:18056443). Required for normal axon formation (PubMed:19812038). Plays a role in microtubule remodeling during neurite extension (PubMed:19668197). Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and destabilizing p53/TP53 (PubMed:14702041). Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity (PubMed:11551964). Inhibits cilia outgrowth (By similarity). Required for cilia disassembly via phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (PubMed:17604723, PubMed:20643351). Regulates protein levels of the anti-apoptosis protein BIRC5 by suppressing the expression of the SCF(FBXL7) E3 ubiquitin-protein ligase substrate adapter FBXL7 through the phosphorylation of the transcription factor FOXP1 (PubMed:28218735). {ECO:0000250|UniProtKB:A0A8I3S724, ECO:0000269|PubMed:11039908, ECO:0000269|PubMed:11551964, ECO:0000269|PubMed:12390251, ECO:0000269|PubMed:13678582, ECO:0000269|PubMed:14523000, ECO:0000269|PubMed:14702041, ECO:0000269|PubMed:15128871, ECO:0000269|PubMed:15147269, ECO:0000269|PubMed:15987997, ECO:0000269|PubMed:17125279, ECO:0000269|PubMed:17360485, ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:18615013, ECO:0000269|PubMed:19351716, ECO:0000269|PubMed:19668197, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:20643351, ECO:0000269|PubMed:26246606, ECO:0000269|PubMed:27192185, ECO:0000269|PubMed:27335426, ECO:0000269|PubMed:28218735}. |
| Q16600 | ZNF239 | S46 | GPS6 | Zinc finger protein 239 (Zinc finger protein HOK-2) (Zinc finger protein MOK-2) | May be involved in transcriptional regulation. |
| O43283 | MAP3K13 | S772 | Sugiyama | Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Leucine zipper-bearing kinase) (Mixed lineage kinase) (MLK) | Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B. {ECO:0000269|PubMed:11726277, ECO:0000269|PubMed:12492477, ECO:0000269|PubMed:9353328}. |
| P08631 | HCK | S78 | Sugiyama | Tyrosine-protein kinase HCK (EC 2.7.10.2) (Hematopoietic cell kinase) (Hemopoietic cell kinase) (p59-HCK/p60-HCK) (p59Hck) (p61Hck) | Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS. {ECO:0000269|PubMed:10092522, ECO:0000269|PubMed:10779760, ECO:0000269|PubMed:10973280, ECO:0000269|PubMed:11741929, ECO:0000269|PubMed:11896602, ECO:0000269|PubMed:12411494, ECO:0000269|PubMed:15010462, ECO:0000269|PubMed:15952790, ECO:0000269|PubMed:15998323, ECO:0000269|PubMed:17310994, ECO:0000269|PubMed:17535448, ECO:0000269|PubMed:19114024, ECO:0000269|PubMed:19903482, ECO:0000269|PubMed:20452982, ECO:0000269|PubMed:21338576, ECO:0000269|PubMed:7535819, ECO:0000269|PubMed:8132624, ECO:0000269|PubMed:9406996, ECO:0000269|PubMed:9407116}. |
| P25205 | MCM3 | S374 | Sugiyama | DNA replication licensing factor MCM3 (EC 3.6.4.12) (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3) (RLF subunit beta) (p102) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for the entry in S phase and for cell division (Probable). {ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000305|PubMed:35585232}. |
| O95819 | MAP4K4 | S800 | Sugiyama | Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase) | Serine/threonine kinase that plays a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway (PubMed:9890973). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). Phosphorylates SMAD1 on Thr-322 (PubMed:21690388). {ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:9890973}. |
| Q6PCE3 | PGM2L1 | S311 | Sugiyama | Glucose 1,6-bisphosphate synthase (EC 2.7.1.106) (PMMLP) (Phosphoglucomutase-2-like 1) | Glucose 1,6-bisphosphate synthase using 1,3-bisphosphoglycerate as a phosphate donor and a series of 1-phosphate sugars, including glucose 1-phosphate, mannose 1-phosphate, ribose 1-phosphate and deoxyribose 1-phosphate, as acceptors (PubMed:17804405). In vitro, also exhibits very low phosphopentomutase and phosphoglucomutase activity which are most probably not physiologically relevant (PubMed:17804405). {ECO:0000269|PubMed:17804405, ECO:0000269|PubMed:18927083, ECO:0000269|PubMed:33979636}. |
| P10768 | ESD | S189 | Sugiyama | S-formylglutathione hydrolase (FGH) (EC 3.1.2.12) (Esterase D) (Methylumbelliferyl-acetate deacetylase) (EC 3.1.1.56) | Serine hydrolase involved in the detoxification of formaldehyde. {ECO:0000269|PubMed:3770744, ECO:0000269|PubMed:4768551}. |
| Q53ET0 | CRTC2 | S348 | SIGNOR|iPTMNet | CREB-regulated transcription coactivator 2 (Transducer of regulated cAMP response element-binding protein 2) (TORC-2) (Transducer of CREB protein 2) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:14536081, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:16809310, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223}. |
| P05423 | POLR3D | S250 | Sugiyama | DNA-directed RNA polymerase III subunit RPC4 (RNA polymerase III subunit C4) (DNA-directed RNA polymerase III subunit D) (Protein BN51) (RNA polymerase III 47 kDa subunit) (RPC53 homolog) | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:12391170, PubMed:20413673, PubMed:33558764, PubMed:34675218, PubMed:35637192). Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. Assembles with POLR3E/RPC5 forming a subcomplex that binds the Pol III core. Enables recruitment of Pol III at transcription initiation site and drives transcription initiation from both type 2 and type 3 DNA promoters. Required for efficient transcription termination and reinitiation (By similarity) (PubMed:12391170, PubMed:20413673, PubMed:35637192). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway (PubMed:19609254, PubMed:19631370). {ECO:0000250|UniProtKB:P25441, ECO:0000269|PubMed:12391170, ECO:0000269|PubMed:19609254, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20413673, ECO:0000269|PubMed:33558764, ECO:0000269|PubMed:34675218, ECO:0000269|PubMed:35637192}. |
| Q14289 | PTK2B | S866 | Sugiyama | Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK) | Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376'. Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca(2+) levels. May also regulate potassium ion transport by phosphorylation of potassium channel subunits. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN; this requires both SRC and PTK2/PYK2. {ECO:0000269|PubMed:10022920, ECO:0000269|PubMed:12771146, ECO:0000269|PubMed:12893833, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:15050747, ECO:0000269|PubMed:15166227, ECO:0000269|PubMed:17634955, ECO:0000269|PubMed:18086875, ECO:0000269|PubMed:18339875, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:18765415, ECO:0000269|PubMed:19086031, ECO:0000269|PubMed:19207108, ECO:0000269|PubMed:19244237, ECO:0000269|PubMed:19428251, ECO:0000269|PubMed:19648005, ECO:0000269|PubMed:19880522, ECO:0000269|PubMed:20001213, ECO:0000269|PubMed:20381867, ECO:0000269|PubMed:20521079, ECO:0000269|PubMed:21357692, ECO:0000269|PubMed:21533080, ECO:0000269|PubMed:7544443, ECO:0000269|PubMed:8670418, ECO:0000269|PubMed:8849729}. |
| P49641 | MAN2A2 | S662 | Sugiyama | Alpha-mannosidase 2x (EC 3.2.1.114) (Alpha-mannosidase IIx) (Man IIx) (Mannosidase alpha class 2A member 2) (Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase) | Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway. |
| Q92793 | CREBBP | S302 | GPS6|SIGNOR|ELM|iPTMNet|EPSD | CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-) | Acetylates histones, giving a specific tag for transcriptional activation (PubMed:21131905, PubMed:24616510). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:24207024, PubMed:28790157, PubMed:30540930, PubMed:35675826, PubMed:9707565). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as lactoyl-CoA, and is able to mediate protein lactylation (PubMed:38128537). Catalyzes lactylation of MRE11 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR) (PubMed:38128537). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000269|PubMed:10490106, ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:24616510, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:30540930, ECO:0000269|PubMed:35675826, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9707565}. |
| P35250 | RFC2 | S85 | Sugiyama | Replication factor C subunit 2 (Activator 1 40 kDa subunit) (A1 40 kDa subunit) (Activator 1 subunit 2) (Replication factor C 40 kDa subunit) (RF-C 40 kDa subunit) (RFC40) | Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA (PubMed:9488738). This subunit binds ATP (By similarity). {ECO:0000250, ECO:0000269|PubMed:9488738}. |
| Q86TU7 | SETD3 | S505 | Sugiyama | Actin-histidine N-methyltransferase (EC 2.1.1.85) (Protein-L-histidine N-tele-methyltransferase) (SET domain-containing protein 3) (hSETD3) | Protein-histidine N-methyltransferase that specifically mediates 3-methylhistidine (tele-methylhistidine) methylation of actin at 'His-73' (PubMed:30526847, PubMed:30626964, PubMed:30785395, PubMed:31388018, PubMed:31993215). Histidine methylation of actin is required for smooth muscle contraction of the laboring uterus during delivery (PubMed:30626964). Does not have protein-lysine N-methyltransferase activity and probably only catalyzes histidine methylation of actin (PubMed:30626964, PubMed:30785395, PubMed:31388018). {ECO:0000269|PubMed:30526847, ECO:0000269|PubMed:30626964, ECO:0000269|PubMed:30785395, ECO:0000269|PubMed:31388018, ECO:0000269|PubMed:31993215}. |
| P08174 | CD55 | S54 | Sugiyama | Complement decay-accelerating factor (CD antigen CD55) | This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade (PubMed:7525274). Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage (PubMed:28657829). {ECO:0000269|PubMed:7525274, ECO:0000305|PubMed:28657829}.; FUNCTION: (Microbial infection) Acts as a receptor for Coxsackievirus A21, coxsackieviruses B1, B3 and B5. {ECO:0000269|PubMed:9151867}.; FUNCTION: (Microbial infection) Acts as a receptor for Human enterovirus 70 and D68 (Probable). {ECO:0000269|PubMed:8764022}.; FUNCTION: (Microbial infection) Acts as a receptor for Human echoviruses 6, 7, 11, 12, 20 and 21. {ECO:0000269|PubMed:7525274, ECO:0000305|PubMed:12409401}. |
| Q6ZRY4 | RBPMS2 | S60 | Sugiyama | RNA-binding protein with multiple splicing 2 (RNA binding protein, mRNA processing factor 2) | RNA-binding protein involved in the regulation of smooth muscle cell differentiation and proliferation in the gastrointestinal system (PubMed:25064856). Binds NOG mRNA, the major inhibitor of the bone morphogenetic protein (BMP) pathway. Mediates an increase of NOG mRNA levels, thereby contributing to the negative regulation of BMP signaling pathway and promoting reversible dedifferentiation and proliferation of smooth muscle cells (By similarity). Acts as a pre-mRNA alternative splicing regulator (By similarity). Mediates ACTN1 and FLNB alternative splicing (By similarity). Likely binds to mRNA tandem CAC trinucleotide or CA dinucleotide motifs (PubMed:24860013). {ECO:0000250|UniProtKB:B5DFF2, ECO:0000250|UniProtKB:Q9W6I1, ECO:0000269|PubMed:24860013, ECO:0000269|PubMed:25064856}. |
| Q96HP0 | DOCK6 | S190 | Sugiyama | Dedicator of cytokinesis protein 6 | Acts as a guanine nucleotide exchange factor (GEF) for CDC42 and RAC1 small GTPases. Through its activation of CDC42 and RAC1, may regulate neurite outgrowth (By similarity). {ECO:0000250, ECO:0000269|PubMed:17196961}. |
| Q9NZ52 | GGA3 | S415 | Sugiyama | ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3) | Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:11301005). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:26811329). nvolved in BACE1 transport and sorting as well as regulation of BACE1 protein levels (PubMed:15615712, PubMed:17553422, PubMed:20484053). Regulates retrograde transport of BACE1 from endosomes to the trans-Golgi network via interaction through the VHS motif and dependent of BACE1 phosphorylation (PubMed:15615712). Modulates BACE1 protein levels independently of the interaction between VHS domain and DXXLL motif through recognition of ubiquitination (PubMed:20484053). Key player in a novel DXXLL-mediated endosomal sorting machinery to the recycling pathway that targets NTRK1 to the plasma membrane (By similarity). {ECO:0000250|UniProtKB:A0A0G2JV04, ECO:0000269|PubMed:11301005, ECO:0000269|PubMed:15615712, ECO:0000269|PubMed:17553422, ECO:0000269|PubMed:20484053, ECO:0000269|PubMed:26811329}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9707616 | Heme signaling | 0.000041 | 4.384 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.000250 | 3.602 |
| R-HSA-211728 | Regulation of PAK-2p34 activity by PS-GAP/RHG10 | 0.000326 | 3.486 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.000364 | 3.439 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.000456 | 3.341 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.000640 | 3.194 |
| R-HSA-428540 | Activation of RAC1 | 0.001036 | 2.985 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.001001 | 3.000 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.001001 | 3.000 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.001317 | 2.880 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.001277 | 2.894 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.001291 | 2.889 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.002299 | 2.639 |
| R-HSA-9707587 | Regulation of HMOX1 expression and activity | 0.002840 | 2.547 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.002882 | 2.540 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.002686 | 2.571 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 0.003463 | 2.461 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.003694 | 2.433 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.003694 | 2.433 |
| R-HSA-176417 | Phosphorylation of Emi1 | 0.004964 | 2.304 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.004964 | 2.304 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.004964 | 2.304 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.005396 | 2.268 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.005962 | 2.225 |
| R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 | 0.006230 | 2.206 |
| R-HSA-164944 | Nef and signal transduction | 0.006230 | 2.206 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.006209 | 2.207 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.006321 | 2.199 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.006329 | 2.199 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.007025 | 2.153 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.007196 | 2.143 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.007484 | 2.126 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.008572 | 2.067 |
| R-HSA-4839726 | Chromatin organization | 0.008841 | 2.053 |
| R-HSA-8875656 | MET receptor recycling | 0.009151 | 2.039 |
| R-HSA-194138 | Signaling by VEGF | 0.010232 | 1.990 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.010439 | 1.981 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.010496 | 1.979 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.011164 | 1.952 |
| R-HSA-9843745 | Adipogenesis | 0.012746 | 1.895 |
| R-HSA-9909396 | Circadian clock | 0.013138 | 1.881 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 0.014453 | 1.840 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.013439 | 1.872 |
| R-HSA-1483248 | Synthesis of PIPs at the ER membrane | 0.014453 | 1.840 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.014535 | 1.838 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.016453 | 1.784 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.015537 | 1.809 |
| R-HSA-2559583 | Cellular Senescence | 0.015599 | 1.807 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.016347 | 1.787 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.016576 | 1.781 |
| R-HSA-69275 | G2/M Transition | 0.018024 | 1.744 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.017604 | 1.754 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.018563 | 1.731 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.018563 | 1.731 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.018563 | 1.731 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.018889 | 1.724 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 0.020781 | 1.682 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.022494 | 1.648 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.021627 | 1.665 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 0.020781 | 1.682 |
| R-HSA-9683610 | Maturation of nucleoprotein | 0.020781 | 1.682 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 0.023104 | 1.636 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.024925 | 1.603 |
| R-HSA-5619088 | Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ... | 0.025504 | 1.593 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.025528 | 1.593 |
| R-HSA-176412 | Phosphorylation of the APC/C | 0.028050 | 1.552 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.030668 | 1.513 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.030668 | 1.513 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.030668 | 1.513 |
| R-HSA-6806834 | Signaling by MET | 0.028136 | 1.551 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 0.030668 | 1.513 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.028524 | 1.545 |
| R-HSA-73930 | Abasic sugar-phosphate removal via the single-nucleotide replacement pathway | 0.038013 | 1.420 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 0.050361 | 1.298 |
| R-HSA-8874177 | ATF6B (ATF6-beta) activates chaperones | 0.050361 | 1.298 |
| R-HSA-211736 | Stimulation of the cell death response by PAK-2p34 | 0.050361 | 1.298 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 0.050361 | 1.298 |
| R-HSA-8854521 | Interaction between PHLDA1 and AURKA | 0.050361 | 1.298 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 0.050361 | 1.298 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 0.050361 | 1.298 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 0.050361 | 1.298 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 0.050361 | 1.298 |
| R-HSA-68881 | Mitotic Metaphase/Anaphase Transition | 0.050361 | 1.298 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 0.050361 | 1.298 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 0.050361 | 1.298 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 0.050361 | 1.298 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 0.050361 | 1.298 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 0.050361 | 1.298 |
| R-HSA-3249367 | STAT6-mediated induction of chemokines | 0.062552 | 1.204 |
| R-HSA-8941237 | Invadopodia formation | 0.062552 | 1.204 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.062552 | 1.204 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.062552 | 1.204 |
| R-HSA-8865999 | MET activates PTPN11 | 0.062552 | 1.204 |
| R-HSA-1296061 | HCN channels | 0.074587 | 1.127 |
| R-HSA-9818035 | NFE2L2 regulating ER-stress associated genes | 0.074587 | 1.127 |
| R-HSA-74713 | IRS activation | 0.086469 | 1.063 |
| R-HSA-9818026 | NFE2L2 regulating inflammation associated genes | 0.086469 | 1.063 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 0.098198 | 1.008 |
| R-HSA-69478 | G2/M DNA replication checkpoint | 0.109778 | 0.959 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 0.109778 | 0.959 |
| R-HSA-6802953 | RAS signaling downstream of NF1 loss-of-function variants | 0.109778 | 0.959 |
| R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 0.121209 | 0.916 |
| R-HSA-8851907 | MET activates PI3K/AKT signaling | 0.121209 | 0.916 |
| R-HSA-112412 | SOS-mediated signalling | 0.121209 | 0.916 |
| R-HSA-3785653 | Myoclonic epilepsy of Lafora | 0.132495 | 0.878 |
| R-HSA-9028335 | Activated NTRK2 signals through PI3K | 0.132495 | 0.878 |
| R-HSA-9768778 | Regulation of NPAS4 mRNA translation | 0.132495 | 0.878 |
| R-HSA-5654710 | PI-3K cascade:FGFR3 | 0.039068 | 1.408 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 0.143636 | 0.843 |
| R-HSA-5654720 | PI-3K cascade:FGFR4 | 0.042041 | 1.376 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 0.154635 | 0.811 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.048230 | 1.317 |
| R-HSA-5654689 | PI-3K cascade:FGFR1 | 0.051441 | 1.289 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.165493 | 0.781 |
| R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | 0.165493 | 0.781 |
| R-HSA-5654695 | PI-3K cascade:FGFR2 | 0.061510 | 1.211 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.075868 | 1.120 |
| R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 0.217738 | 0.662 |
| R-HSA-73780 | RNA Polymerase III Chain Elongation | 0.217738 | 0.662 |
| R-HSA-5656121 | Translesion synthesis by POLI | 0.227789 | 0.642 |
| R-HSA-8964616 | G beta:gamma signalling through CDC42 | 0.237712 | 0.624 |
| R-HSA-5655862 | Translesion synthesis by POLK | 0.237712 | 0.624 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.071939 | 1.143 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.078869 | 1.103 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.088542 | 1.053 |
| R-HSA-380287 | Centrosome maturation | 0.093557 | 1.029 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.200702 | 0.697 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.131682 | 0.880 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.233711 | 0.631 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.233711 | 0.631 |
| R-HSA-1989781 | PPARA activates gene expression | 0.186669 | 0.729 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.191845 | 0.717 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 0.197242 | 0.705 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.065004 | 1.187 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.075868 | 1.120 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.079609 | 1.099 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.036316 | 1.440 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.036316 | 1.440 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 0.042041 | 1.376 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.128343 | 0.892 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.036316 | 1.440 |
| R-HSA-73893 | DNA Damage Bypass | 0.168337 | 0.774 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.111400 | 0.953 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 0.154635 | 0.811 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.058083 | 1.236 |
| R-HSA-9762292 | Regulation of CDH11 function | 0.154635 | 0.811 |
| R-HSA-198203 | PI3K/AKT activation | 0.154635 | 0.811 |
| R-HSA-110312 | Translesion synthesis by REV1 | 0.217738 | 0.662 |
| R-HSA-169911 | Regulation of Apoptosis | 0.103169 | 0.986 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.099119 | 1.004 |
| R-HSA-191650 | Regulation of gap junction activity | 0.074587 | 1.127 |
| R-HSA-69091 | Polymerase switching | 0.186795 | 0.729 |
| R-HSA-69109 | Leading Strand Synthesis | 0.186795 | 0.729 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.052926 | 1.276 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.032325 | 1.490 |
| R-HSA-9028731 | Activated NTRK2 signals through FRS2 and FRS3 | 0.186795 | 0.729 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.186795 | 0.729 |
| R-HSA-9766229 | Degradation of CDH1 | 0.038410 | 1.416 |
| R-HSA-426496 | Post-transcriptional silencing by small RNAs | 0.086469 | 1.063 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.036180 | 1.442 |
| R-HSA-2025928 | Calcineurin activates NFAT | 0.143636 | 0.843 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 0.207556 | 0.683 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.038410 | 1.416 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.091162 | 1.040 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.099119 | 1.004 |
| R-HSA-72187 | mRNA 3'-end processing | 0.182104 | 0.740 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.031842 | 1.497 |
| R-HSA-68877 | Mitotic Prometaphase | 0.141582 | 0.849 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 0.075868 | 1.120 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 0.079609 | 1.099 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 0.103169 | 0.986 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.064755 | 1.189 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.064755 | 1.189 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.109276 | 0.961 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 0.103169 | 0.986 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 0.186730 | 0.729 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.081890 | 1.087 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 0.176213 | 0.754 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 0.186795 | 0.729 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.058958 | 1.229 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.058958 | 1.229 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.058958 | 1.229 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.058958 | 1.229 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.069642 | 1.157 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.099119 | 1.004 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.074217 | 1.129 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.052926 | 1.276 |
| R-HSA-8875513 | MET interacts with TNS proteins | 0.062552 | 1.204 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 0.074587 | 1.127 |
| R-HSA-176974 | Unwinding of DNA | 0.143636 | 0.843 |
| R-HSA-68952 | DNA replication initiation | 0.154635 | 0.811 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 0.176213 | 0.754 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.176213 | 0.754 |
| R-HSA-209560 | NF-kB is activated and signals survival | 0.176213 | 0.754 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.186795 | 0.729 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.079609 | 1.099 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.099119 | 1.004 |
| R-HSA-8875878 | MET promotes cell motility | 0.115578 | 0.937 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.061038 | 1.214 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.154763 | 0.810 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.186730 | 0.729 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.224236 | 0.649 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.152482 | 0.817 |
| R-HSA-5693538 | Homology Directed Repair | 0.093140 | 1.031 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.036180 | 1.442 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.181539 | 0.741 |
| R-HSA-9711097 | Cellular response to starvation | 0.194450 | 0.711 |
| R-HSA-193639 | p75NTR signals via NF-kB | 0.217738 | 0.662 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 0.186795 | 0.729 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 0.186795 | 0.729 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.091162 | 1.040 |
| R-HSA-112399 | IRS-mediated signalling | 0.052926 | 1.276 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.078780 | 1.104 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 0.132495 | 0.878 |
| R-HSA-74749 | Signal attenuation | 0.154635 | 0.811 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.075868 | 1.120 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 0.247508 | 0.606 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.034788 | 1.459 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.217738 | 0.662 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.141419 | 0.849 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.075868 | 1.120 |
| R-HSA-9603381 | Activated NTRK3 signals through PI3K | 0.121209 | 0.916 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.115578 | 0.937 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.067479 | 1.171 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.132669 | 0.877 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.150287 | 0.823 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.091162 | 1.040 |
| R-HSA-170968 | Frs2-mediated activation | 0.197242 | 0.705 |
| R-HSA-177929 | Signaling by EGFR | 0.050985 | 1.293 |
| R-HSA-69481 | G2/M Checkpoints | 0.038209 | 1.418 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.200702 | 0.697 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.067479 | 1.171 |
| R-HSA-110381 | Resolution of AP sites via the single-nucleotide replacement pathway | 0.086469 | 1.063 |
| R-HSA-1483226 | Synthesis of PI | 0.165493 | 0.781 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.176213 | 0.754 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 0.068563 | 1.164 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 0.207556 | 0.683 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.083406 | 1.079 |
| R-HSA-69190 | DNA strand elongation | 0.087258 | 1.059 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.200702 | 0.697 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.069693 | 1.157 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.091162 | 1.040 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.080292 | 1.095 |
| R-HSA-9664873 | Pexophagy | 0.154635 | 0.811 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.058958 | 1.229 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.128343 | 0.892 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.096108 | 1.017 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.058083 | 1.236 |
| R-HSA-9842663 | Signaling by LTK | 0.186795 | 0.729 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.228970 | 0.640 |
| R-HSA-69239 | Synthesis of DNA | 0.200085 | 0.699 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.146435 | 0.834 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 0.109778 | 0.959 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 0.207556 | 0.683 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.103169 | 0.986 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.210084 | 0.678 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.083645 | 1.078 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.083645 | 1.078 |
| R-HSA-3928664 | Ephrin signaling | 0.036180 | 1.442 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.163789 | 0.786 |
| R-HSA-1640170 | Cell Cycle | 0.091820 | 1.037 |
| R-HSA-75153 | Apoptotic execution phase | 0.033574 | 1.474 |
| R-HSA-169893 | Prolonged ERK activation events | 0.227789 | 0.642 |
| R-HSA-9706374 | FLT3 signaling through SRC family kinases | 0.074587 | 1.127 |
| R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 0.143636 | 0.843 |
| R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 0.143636 | 0.843 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 0.176213 | 0.754 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.227789 | 0.642 |
| R-HSA-9634600 | Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | 0.227789 | 0.642 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.054902 | 1.260 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.172906 | 0.762 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.177496 | 0.751 |
| R-HSA-2262752 | Cellular responses to stress | 0.080873 | 1.092 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.041977 | 1.377 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 0.227789 | 0.642 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.210084 | 0.678 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 0.247508 | 0.606 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.247965 | 0.606 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.219510 | 0.659 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.228970 | 0.640 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.119788 | 0.922 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.075783 | 1.120 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.149409 | 0.826 |
| R-HSA-8853659 | RET signaling | 0.107263 | 0.970 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.070800 | 1.150 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.086469 | 1.063 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 0.098198 | 1.008 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 0.197242 | 0.705 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 0.247508 | 0.606 |
| R-HSA-3229121 | Glycogen storage diseases | 0.247508 | 0.606 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.132669 | 0.877 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.098687 | 1.006 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.196031 | 0.708 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.214792 | 0.668 |
| R-HSA-3214847 | HATs acetylate histones | 0.171078 | 0.767 |
| R-HSA-73884 | Base Excision Repair | 0.137518 | 0.862 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.115541 | 0.937 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.068563 | 1.164 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 0.247508 | 0.606 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.055480 | 1.256 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.101293 | 0.994 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.033426 | 1.476 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.237496 | 0.624 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.237496 | 0.624 |
| R-HSA-166520 | Signaling by NTRKs | 0.065606 | 1.183 |
| R-HSA-442380 | Zinc influx into cells by the SLC39 gene family | 0.143636 | 0.843 |
| R-HSA-109704 | PI3K Cascade | 0.040097 | 1.397 |
| R-HSA-9706369 | Negative regulation of FLT3 | 0.227789 | 0.642 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 0.227789 | 0.642 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.247508 | 0.606 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.247508 | 0.606 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.081241 | 1.090 |
| R-HSA-162582 | Signal Transduction | 0.077898 | 1.108 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.145839 | 0.836 |
| R-HSA-9675135 | Diseases of DNA repair | 0.154763 | 0.810 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.050985 | 1.293 |
| R-HSA-109581 | Apoptosis | 0.204980 | 0.688 |
| R-HSA-397014 | Muscle contraction | 0.182955 | 0.738 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.207556 | 0.683 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 0.217738 | 0.662 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.146435 | 0.834 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.240361 | 0.619 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.198923 | 0.701 |
| R-HSA-2586552 | Signaling by Leptin | 0.154635 | 0.811 |
| R-HSA-9020558 | Interleukin-2 signaling | 0.165493 | 0.781 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.036761 | 1.435 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.137028 | 0.863 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.132495 | 0.878 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 0.054726 | 1.262 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 0.176213 | 0.754 |
| R-HSA-391160 | Signal regulatory protein family interactions | 0.207556 | 0.683 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.217738 | 0.662 |
| R-HSA-201556 | Signaling by ALK | 0.119796 | 0.922 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.093140 | 1.031 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 0.065004 | 1.187 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.140469 | 0.852 |
| R-HSA-435354 | Zinc transporters | 0.207556 | 0.683 |
| R-HSA-417957 | P2Y receptors | 0.207556 | 0.683 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.125936 | 0.900 |
| R-HSA-73887 | Death Receptor Signaling | 0.184098 | 0.735 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.231989 | 0.635 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.083417 | 1.079 |
| R-HSA-373755 | Semaphorin interactions | 0.233711 | 0.631 |
| R-HSA-9694631 | Maturation of nucleoprotein | 0.039068 | 1.408 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.079609 | 1.099 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.065298 | 1.185 |
| R-HSA-9607240 | FLT3 Signaling | 0.128343 | 0.892 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.107263 | 0.970 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.101293 | 0.994 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.182104 | 0.740 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.068282 | 1.166 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.228970 | 0.640 |
| R-HSA-202433 | Generation of second messenger molecules | 0.124052 | 0.906 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.103928 | 0.983 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.119796 | 0.922 |
| R-HSA-1483255 | PI Metabolism | 0.180610 | 0.743 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.124052 | 0.906 |
| R-HSA-449147 | Signaling by Interleukins | 0.133915 | 0.873 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.098687 | 1.006 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.082551 | 1.083 |
| R-HSA-2028269 | Signaling by Hippo | 0.247508 | 0.606 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.146435 | 0.834 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.243210 | 0.614 |
| R-HSA-9683701 | Translation of Structural Proteins | 0.132669 | 0.877 |
| R-HSA-68875 | Mitotic Prophase | 0.250643 | 0.601 |
| R-HSA-1266738 | Developmental Biology | 0.252299 | 0.598 |
| R-HSA-196807 | Nicotinate metabolism | 0.252724 | 0.597 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.254085 | 0.595 |
| R-HSA-180292 | GAB1 signalosome | 0.257179 | 0.590 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 0.257179 | 0.590 |
| R-HSA-5358508 | Mismatch Repair | 0.257179 | 0.590 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.257179 | 0.590 |
| R-HSA-418038 | Nucleotide-like (purinergic) receptors | 0.257179 | 0.590 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.260990 | 0.583 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 0.266726 | 0.574 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.266726 | 0.574 |
| R-HSA-110320 | Translesion Synthesis by POLH | 0.266726 | 0.574 |
| R-HSA-500753 | Pyrimidine biosynthesis | 0.266726 | 0.574 |
| R-HSA-912631 | Regulation of signaling by CBL | 0.266726 | 0.574 |
| R-HSA-429958 | mRNA decay by 3' to 5' exoribonuclease | 0.266726 | 0.574 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 0.266726 | 0.574 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 0.266726 | 0.574 |
| R-HSA-392517 | Rap1 signalling | 0.266726 | 0.574 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 0.266726 | 0.574 |
| R-HSA-844456 | The NLRP3 inflammasome | 0.266726 | 0.574 |
| R-HSA-1500931 | Cell-Cell communication | 0.268841 | 0.571 |
| R-HSA-69206 | G1/S Transition | 0.271392 | 0.566 |
| R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 0.276151 | 0.559 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.276151 | 0.559 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.276151 | 0.559 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.276151 | 0.559 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.276151 | 0.559 |
| R-HSA-3322077 | Glycogen synthesis | 0.276151 | 0.559 |
| R-HSA-445144 | Signal transduction by L1 | 0.276151 | 0.559 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.276151 | 0.559 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.276537 | 0.558 |
| R-HSA-69186 | Lagging Strand Synthesis | 0.285455 | 0.544 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 0.285455 | 0.544 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.285455 | 0.544 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.285455 | 0.544 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 0.285455 | 0.544 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.285455 | 0.544 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.286055 | 0.544 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.288824 | 0.539 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.290810 | 0.536 |
| R-HSA-5654706 | FRS-mediated FGFR3 signaling | 0.294640 | 0.531 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 0.294640 | 0.531 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 0.294640 | 0.531 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.294640 | 0.531 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.294640 | 0.531 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.295561 | 0.529 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.302640 | 0.519 |
| R-HSA-5654712 | FRS-mediated FGFR4 signaling | 0.303708 | 0.518 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 0.303708 | 0.518 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 0.303708 | 0.518 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.303708 | 0.518 |
| R-HSA-975578 | Reactions specific to the complex N-glycan synthesis pathway | 0.303708 | 0.518 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.303708 | 0.518 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 0.312660 | 0.505 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 0.312660 | 0.505 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 0.312660 | 0.505 |
| R-HSA-3000170 | Syndecan interactions | 0.312660 | 0.505 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.312660 | 0.505 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.312660 | 0.505 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.314514 | 0.502 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.321497 | 0.493 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.321497 | 0.493 |
| R-HSA-429947 | Deadenylation of mRNA | 0.321497 | 0.493 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.323950 | 0.490 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.330221 | 0.481 |
| R-HSA-5654693 | FRS-mediated FGFR1 signaling | 0.330221 | 0.481 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 0.330221 | 0.481 |
| R-HSA-9839394 | TGFBR3 expression | 0.330221 | 0.481 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 0.330221 | 0.481 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.330221 | 0.481 |
| R-HSA-5357801 | Programmed Cell Death | 0.331632 | 0.479 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.333353 | 0.477 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.338834 | 0.470 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.338834 | 0.470 |
| R-HSA-70635 | Urea cycle | 0.338834 | 0.470 |
| R-HSA-446728 | Cell junction organization | 0.341453 | 0.467 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.342628 | 0.465 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.342719 | 0.465 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.342719 | 0.465 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.342719 | 0.465 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.344967 | 0.462 |
| R-HSA-75109 | Triglyceride biosynthesis | 0.347336 | 0.459 |
| R-HSA-1483213 | Synthesis of PE | 0.347336 | 0.459 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.347336 | 0.459 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.347336 | 0.459 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.352043 | 0.453 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.355486 | 0.449 |
| R-HSA-5654700 | FRS-mediated FGFR2 signaling | 0.355730 | 0.449 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.355730 | 0.449 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.355730 | 0.449 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 0.355730 | 0.449 |
| R-HSA-622312 | Inflammasomes | 0.355730 | 0.449 |
| R-HSA-69242 | S Phase | 0.362488 | 0.441 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 0.364016 | 0.439 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.364016 | 0.439 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.364016 | 0.439 |
| R-HSA-199991 | Membrane Trafficking | 0.364429 | 0.438 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.365942 | 0.437 |
| R-HSA-418990 | Adherens junctions interactions | 0.369509 | 0.432 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.370550 | 0.431 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.370876 | 0.431 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.372196 | 0.429 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.372196 | 0.429 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.372196 | 0.429 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.372196 | 0.429 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.376454 | 0.424 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.376454 | 0.424 |
| R-HSA-9675108 | Nervous system development | 0.377424 | 0.423 |
| R-HSA-69306 | DNA Replication | 0.379937 | 0.420 |
| R-HSA-212436 | Generic Transcription Pathway | 0.380255 | 0.420 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.380271 | 0.420 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.380271 | 0.420 |
| R-HSA-182971 | EGFR downregulation | 0.380271 | 0.420 |
| R-HSA-2129379 | Molecules associated with elastic fibres | 0.380271 | 0.420 |
| R-HSA-186763 | Downstream signal transduction | 0.380271 | 0.420 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.384730 | 0.415 |
| R-HSA-1483257 | Phospholipid metabolism | 0.384730 | 0.415 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.388243 | 0.411 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.388243 | 0.411 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.393384 | 0.405 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.396113 | 0.402 |
| R-HSA-397795 | G-protein beta:gamma signalling | 0.396113 | 0.402 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.396113 | 0.402 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.396113 | 0.402 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.402414 | 0.395 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.403882 | 0.394 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.403882 | 0.394 |
| R-HSA-189483 | Heme degradation | 0.403882 | 0.394 |
| R-HSA-190236 | Signaling by FGFR | 0.411381 | 0.386 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.411552 | 0.386 |
| R-HSA-5205647 | Mitophagy | 0.411552 | 0.386 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 0.411552 | 0.386 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.419123 | 0.378 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.419123 | 0.378 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.419123 | 0.378 |
| R-HSA-187687 | Signalling to ERKs | 0.419123 | 0.378 |
| R-HSA-381042 | PERK regulates gene expression | 0.419123 | 0.378 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.420281 | 0.376 |
| R-HSA-70171 | Glycolysis | 0.420281 | 0.376 |
| R-HSA-68886 | M Phase | 0.420495 | 0.376 |
| R-HSA-74160 | Gene expression (Transcription) | 0.423383 | 0.373 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.426597 | 0.370 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.426597 | 0.370 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.426597 | 0.370 |
| R-HSA-157118 | Signaling by NOTCH | 0.433161 | 0.363 |
| R-HSA-419037 | NCAM1 interactions | 0.433976 | 0.363 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.433976 | 0.363 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.433976 | 0.363 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.437874 | 0.359 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.437874 | 0.359 |
| R-HSA-1566948 | Elastic fibre formation | 0.441260 | 0.355 |
| R-HSA-9833110 | RSV-host interactions | 0.442227 | 0.354 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.445320 | 0.351 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.446561 | 0.350 |
| R-HSA-422475 | Axon guidance | 0.448328 | 0.348 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.448444 | 0.348 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.455140 | 0.342 |
| R-HSA-3371568 | Attenuation phase | 0.455550 | 0.341 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.455550 | 0.341 |
| R-HSA-8982491 | Glycogen metabolism | 0.455550 | 0.341 |
| R-HSA-975576 | N-glycan antennae elongation in the medial/trans-Golgi | 0.455550 | 0.341 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.458476 | 0.339 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 0.462558 | 0.335 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.462558 | 0.335 |
| R-HSA-9694548 | Maturation of spike protein | 0.462558 | 0.335 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.463710 | 0.334 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.463710 | 0.334 |
| R-HSA-421270 | Cell-cell junction organization | 0.464383 | 0.333 |
| R-HSA-202403 | TCR signaling | 0.467948 | 0.330 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.469476 | 0.328 |
| R-HSA-165159 | MTOR signalling | 0.476306 | 0.322 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.476365 | 0.322 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.480544 | 0.318 |
| R-HSA-8854214 | TBC/RABGAPs | 0.483048 | 0.316 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.483048 | 0.316 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.484702 | 0.315 |
| R-HSA-373752 | Netrin-1 signaling | 0.489703 | 0.310 |
| R-HSA-5683826 | Surfactant metabolism | 0.489703 | 0.310 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.489703 | 0.310 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.492956 | 0.307 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.502352 | 0.299 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.502760 | 0.299 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.502760 | 0.299 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.502760 | 0.299 |
| R-HSA-70326 | Glucose metabolism | 0.505180 | 0.297 |
| R-HSA-5617833 | Cilium Assembly | 0.507402 | 0.295 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.509163 | 0.293 |
| R-HSA-1483191 | Synthesis of PC | 0.509163 | 0.293 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.513223 | 0.290 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.513755 | 0.289 |
| R-HSA-5620924 | Intraflagellar transport | 0.515484 | 0.288 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.515484 | 0.288 |
| R-HSA-425410 | Metal ion SLC transporters | 0.515484 | 0.288 |
| R-HSA-3371556 | Cellular response to heat stress | 0.521181 | 0.283 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.521724 | 0.283 |
| R-HSA-9609690 | HCMV Early Events | 0.526328 | 0.279 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.527884 | 0.277 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.529051 | 0.277 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.532953 | 0.273 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.532953 | 0.273 |
| R-HSA-977606 | Regulation of Complement cascade | 0.536834 | 0.270 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.538723 | 0.269 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.539968 | 0.268 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.539968 | 0.268 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.544850 | 0.264 |
| R-HSA-73894 | DNA Repair | 0.545229 | 0.263 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.545894 | 0.263 |
| R-HSA-8956320 | Nucleotide biosynthesis | 0.545894 | 0.263 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.547897 | 0.261 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.547897 | 0.261 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.557519 | 0.254 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.557519 | 0.254 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.563220 | 0.249 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.579888 | 0.237 |
| R-HSA-180786 | Extension of Telomeres | 0.579888 | 0.237 |
| R-HSA-8979227 | Triglyceride metabolism | 0.579888 | 0.237 |
| R-HSA-186712 | Regulation of beta-cell development | 0.579888 | 0.237 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.585302 | 0.233 |
| R-HSA-156590 | Glutathione conjugation | 0.585302 | 0.233 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.588811 | 0.230 |
| R-HSA-68882 | Mitotic Anaphase | 0.589267 | 0.230 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.590647 | 0.229 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.590647 | 0.229 |
| R-HSA-1442490 | Collagen degradation | 0.590647 | 0.229 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.592128 | 0.228 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.592355 | 0.227 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.595923 | 0.225 |
| R-HSA-186797 | Signaling by PDGF | 0.595923 | 0.225 |
| R-HSA-6807070 | PTEN Regulation | 0.599374 | 0.222 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.599374 | 0.222 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.602849 | 0.220 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.602849 | 0.220 |
| R-HSA-9664407 | Parasite infection | 0.602849 | 0.220 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.606273 | 0.217 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.606273 | 0.217 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.606302 | 0.217 |
| R-HSA-1632852 | Macroautophagy | 0.606302 | 0.217 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.611349 | 0.214 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.613139 | 0.212 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.621306 | 0.207 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.622748 | 0.206 |
| R-HSA-166658 | Complement cascade | 0.623225 | 0.205 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.629837 | 0.201 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.632159 | 0.199 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.635767 | 0.197 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.640464 | 0.194 |
| R-HSA-3000178 | ECM proteoglycans | 0.640464 | 0.194 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.640464 | 0.194 |
| R-HSA-189445 | Metabolism of porphyrins | 0.640464 | 0.194 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.645101 | 0.190 |
| R-HSA-9609507 | Protein localization | 0.649130 | 0.188 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.649679 | 0.187 |
| R-HSA-4086398 | Ca2+ pathway | 0.649679 | 0.187 |
| R-HSA-5663084 | Diseases of carbohydrate metabolism | 0.649679 | 0.187 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.652268 | 0.186 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.654198 | 0.184 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.654198 | 0.184 |
| R-HSA-9612973 | Autophagy | 0.658476 | 0.181 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.658658 | 0.181 |
| R-HSA-917937 | Iron uptake and transport | 0.658658 | 0.181 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.658658 | 0.181 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.658658 | 0.181 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.670626 | 0.174 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.671699 | 0.173 |
| R-HSA-216083 | Integrin cell surface interactions | 0.671699 | 0.173 |
| R-HSA-9609646 | HCMV Infection | 0.679182 | 0.168 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.680117 | 0.167 |
| R-HSA-9833482 | PKR-mediated signaling | 0.680117 | 0.167 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.680117 | 0.167 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.680117 | 0.167 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.682426 | 0.166 |
| R-HSA-977225 | Amyloid fiber formation | 0.684245 | 0.165 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.696313 | 0.157 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.700233 | 0.155 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.700233 | 0.155 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.707922 | 0.150 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.709487 | 0.149 |
| R-HSA-9663891 | Selective autophagy | 0.715415 | 0.145 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.715769 | 0.145 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 0.722717 | 0.141 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.726297 | 0.139 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.730834 | 0.136 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.736335 | 0.133 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.736765 | 0.133 |
| R-HSA-2029481 | FCGR activation | 0.736765 | 0.133 |
| R-HSA-9658195 | Leishmania infection | 0.747772 | 0.126 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.747772 | 0.126 |
| R-HSA-1296071 | Potassium Channels | 0.750105 | 0.125 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.750105 | 0.125 |
| R-HSA-157579 | Telomere Maintenance | 0.753334 | 0.123 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.753334 | 0.123 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.753334 | 0.123 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.756521 | 0.121 |
| R-HSA-9679506 | SARS-CoV Infections | 0.756900 | 0.121 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.759667 | 0.119 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.763454 | 0.117 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.765838 | 0.116 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.774800 | 0.111 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.775868 | 0.110 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.776523 | 0.110 |
| R-HSA-163125 | Post-translational modification: synthesis of GPI-anchored proteins | 0.777711 | 0.109 |
| R-HSA-195721 | Signaling by WNT | 0.780147 | 0.108 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.782283 | 0.107 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.783421 | 0.106 |
| R-HSA-211000 | Gene Silencing by RNA | 0.786221 | 0.104 |
| R-HSA-6805567 | Keratinization | 0.790588 | 0.102 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.799690 | 0.097 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.807362 | 0.093 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.812314 | 0.090 |
| R-HSA-373760 | L1CAM interactions | 0.814742 | 0.089 |
| R-HSA-8957322 | Metabolism of steroids | 0.823005 | 0.085 |
| R-HSA-73886 | Chromosome Maintenance | 0.826421 | 0.083 |
| R-HSA-162906 | HIV Infection | 0.829766 | 0.081 |
| R-HSA-1474244 | Extracellular matrix organization | 0.833259 | 0.079 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.834793 | 0.078 |
| R-HSA-1643685 | Disease | 0.834861 | 0.078 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.839473 | 0.076 |
| R-HSA-114608 | Platelet degranulation | 0.841552 | 0.075 |
| R-HSA-8939211 | ESR-mediated signaling | 0.846007 | 0.073 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.853471 | 0.069 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.855369 | 0.068 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.862719 | 0.064 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.866254 | 0.062 |
| R-HSA-9824446 | Viral Infection Pathways | 0.882009 | 0.055 |
| R-HSA-416476 | G alpha (q) signalling events | 0.883084 | 0.054 |
| R-HSA-9758941 | Gastrulation | 0.885637 | 0.053 |
| R-HSA-1280218 | Adaptive Immune System | 0.888138 | 0.052 |
| R-HSA-9610379 | HCMV Late Events | 0.896979 | 0.047 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.898315 | 0.047 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.899946 | 0.046 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.902019 | 0.045 |
| R-HSA-5619102 | SLC transporter disorders | 0.909594 | 0.041 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.914199 | 0.039 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.917498 | 0.037 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.917498 | 0.037 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.927171 | 0.033 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.932195 | 0.030 |
| R-HSA-983712 | Ion channel transport | 0.933077 | 0.030 |
| R-HSA-5663205 | Infectious disease | 0.937154 | 0.028 |
| R-HSA-168249 | Innate Immune System | 0.937989 | 0.028 |
| R-HSA-168256 | Immune System | 0.945709 | 0.024 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.946810 | 0.024 |
| R-HSA-8951664 | Neddylation | 0.956565 | 0.019 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.959843 | 0.018 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.960892 | 0.017 |
| R-HSA-72312 | rRNA processing | 0.962401 | 0.017 |
| R-HSA-15869 | Metabolism of nucleotides | 0.964324 | 0.016 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 0.965702 | 0.015 |
| R-HSA-913531 | Interferon Signaling | 0.967810 | 0.014 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.969122 | 0.014 |
| R-HSA-5688426 | Deubiquitination | 0.972203 | 0.012 |
| R-HSA-372790 | Signaling by GPCR | 0.972623 | 0.012 |
| R-HSA-388396 | GPCR downstream signalling | 0.977896 | 0.010 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.978348 | 0.010 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.980512 | 0.009 |
| R-HSA-8953854 | Metabolism of RNA | 0.987263 | 0.006 |
| R-HSA-112316 | Neuronal System | 0.987691 | 0.005 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.994933 | 0.002 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.995620 | 0.002 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.995791 | 0.002 |
| R-HSA-418594 | G alpha (i) signalling events | 0.996314 | 0.002 |
| R-HSA-500792 | GPCR ligand binding | 0.997016 | 0.001 |
| R-HSA-5668914 | Diseases of metabolism | 0.997174 | 0.001 |
| R-HSA-72766 | Translation | 0.997248 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 0.998000 | 0.001 |
| R-HSA-6798695 | Neutrophil degranulation | 0.998104 | 0.001 |
| R-HSA-109582 | Hemostasis | 0.998333 | 0.001 |
| R-HSA-211859 | Biological oxidations | 0.999214 | 0.000 |
| R-HSA-597592 | Post-translational protein modification | 0.999578 | 0.000 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.999780 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 0.999828 | 0.000 |
| R-HSA-392499 | Metabolism of proteins | 0.999992 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
MARK4 |
0.865 | 0.534 | 4 | 0.757 |
MARK3 |
0.864 | 0.589 | 4 | 0.811 |
QSK |
0.863 | 0.502 | 4 | 0.775 |
MARK2 |
0.858 | 0.573 | 4 | 0.784 |
AMPKA1 |
0.857 | 0.391 | -3 | 0.908 |
PRKD1 |
0.855 | 0.193 | -3 | 0.896 |
AMPKA2 |
0.855 | 0.354 | -3 | 0.889 |
SIK |
0.854 | 0.412 | -3 | 0.830 |
TSSK1 |
0.854 | 0.366 | -3 | 0.925 |
NDR2 |
0.851 | 0.125 | -3 | 0.894 |
CLK3 |
0.851 | 0.166 | 1 | 0.835 |
PIM3 |
0.849 | 0.131 | -3 | 0.887 |
MARK1 |
0.849 | 0.493 | 4 | 0.777 |
COT |
0.848 | 0.040 | 2 | 0.881 |
PRKD2 |
0.848 | 0.161 | -3 | 0.855 |
NUAK2 |
0.847 | 0.233 | -3 | 0.895 |
BRSK1 |
0.846 | 0.299 | -3 | 0.863 |
TSSK2 |
0.846 | 0.307 | -5 | 0.866 |
SKMLCK |
0.845 | 0.216 | -2 | 0.868 |
HIPK4 |
0.845 | 0.192 | 1 | 0.807 |
CAMK1B |
0.843 | 0.168 | -3 | 0.895 |
BRSK2 |
0.843 | 0.304 | -3 | 0.878 |
RSK2 |
0.843 | 0.125 | -3 | 0.843 |
NDR1 |
0.841 | 0.109 | -3 | 0.891 |
AURC |
0.841 | 0.165 | -2 | 0.696 |
CDC7 |
0.841 | 0.049 | 1 | 0.839 |
PIM1 |
0.840 | 0.136 | -3 | 0.845 |
QIK |
0.840 | 0.326 | -3 | 0.880 |
P90RSK |
0.840 | 0.117 | -3 | 0.841 |
MAPKAPK2 |
0.840 | 0.116 | -3 | 0.817 |
LATS2 |
0.839 | 0.078 | -5 | 0.738 |
MAPKAPK3 |
0.839 | 0.121 | -3 | 0.859 |
RSK3 |
0.839 | 0.122 | -3 | 0.840 |
CAMK2D |
0.839 | 0.093 | -3 | 0.887 |
NUAK1 |
0.839 | 0.234 | -3 | 0.858 |
SSTK |
0.838 | 0.381 | 4 | 0.708 |
SRPK1 |
0.838 | 0.119 | -3 | 0.817 |
PKACG |
0.837 | 0.123 | -2 | 0.743 |
WNK1 |
0.837 | 0.121 | -2 | 0.858 |
PKN3 |
0.837 | 0.082 | -3 | 0.879 |
PKACB |
0.836 | 0.165 | -2 | 0.705 |
RAF1 |
0.836 | 0.036 | 1 | 0.884 |
HUNK |
0.835 | 0.112 | 2 | 0.825 |
MTOR |
0.835 | -0.021 | 1 | 0.817 |
MELK |
0.835 | 0.209 | -3 | 0.878 |
TBK1 |
0.834 | 0.020 | 1 | 0.803 |
PRPK |
0.834 | -0.054 | -1 | 0.871 |
NIM1 |
0.834 | 0.177 | 3 | 0.798 |
CDKL1 |
0.834 | 0.090 | -3 | 0.850 |
MNK2 |
0.834 | 0.144 | -2 | 0.807 |
CAMK2A |
0.834 | 0.100 | 2 | 0.843 |
CAMLCK |
0.833 | 0.143 | -2 | 0.851 |
ATR |
0.833 | 0.073 | 1 | 0.886 |
CAMK2B |
0.833 | 0.082 | 2 | 0.844 |
PKCD |
0.833 | 0.103 | 2 | 0.779 |
IKKB |
0.832 | -0.052 | -2 | 0.701 |
PKN2 |
0.832 | 0.083 | -3 | 0.890 |
MOS |
0.832 | 0.015 | 1 | 0.855 |
DAPK2 |
0.832 | 0.155 | -3 | 0.899 |
PRKD3 |
0.832 | 0.138 | -3 | 0.826 |
RSK4 |
0.832 | 0.131 | -3 | 0.817 |
CDKL5 |
0.832 | 0.092 | -3 | 0.851 |
NIK |
0.832 | 0.124 | -3 | 0.902 |
PRKX |
0.831 | 0.153 | -3 | 0.781 |
SRPK2 |
0.831 | 0.116 | -3 | 0.747 |
PAK1 |
0.831 | 0.118 | -2 | 0.811 |
P70S6KB |
0.831 | 0.095 | -3 | 0.857 |
MSK1 |
0.831 | 0.133 | -3 | 0.824 |
MSK2 |
0.830 | 0.105 | -3 | 0.809 |
CLK2 |
0.830 | 0.161 | -3 | 0.822 |
CLK1 |
0.830 | 0.161 | -3 | 0.822 |
ICK |
0.829 | 0.095 | -3 | 0.883 |
CLK4 |
0.829 | 0.146 | -3 | 0.832 |
ULK2 |
0.829 | -0.060 | 2 | 0.797 |
CAMK2G |
0.829 | -0.039 | 2 | 0.861 |
MST4 |
0.829 | 0.046 | 2 | 0.842 |
PDHK4 |
0.829 | -0.122 | 1 | 0.881 |
GCN2 |
0.829 | -0.099 | 2 | 0.817 |
NLK |
0.828 | 0.024 | 1 | 0.850 |
PAK3 |
0.828 | 0.107 | -2 | 0.809 |
IKKE |
0.828 | -0.026 | 1 | 0.800 |
SGK3 |
0.827 | 0.151 | -3 | 0.853 |
AURB |
0.827 | 0.139 | -2 | 0.696 |
PDHK1 |
0.827 | -0.076 | 1 | 0.881 |
LATS1 |
0.826 | 0.107 | -3 | 0.899 |
PKG2 |
0.826 | 0.132 | -2 | 0.694 |
IKKA |
0.826 | -0.004 | -2 | 0.682 |
CHK1 |
0.826 | 0.147 | -3 | 0.893 |
MNK1 |
0.825 | 0.117 | -2 | 0.808 |
CAMK4 |
0.825 | 0.078 | -3 | 0.874 |
DSTYK |
0.825 | -0.076 | 2 | 0.887 |
TGFBR2 |
0.825 | -0.015 | -2 | 0.738 |
BCKDK |
0.824 | -0.055 | -1 | 0.833 |
DYRK2 |
0.824 | 0.093 | 1 | 0.709 |
BMPR2 |
0.824 | -0.112 | -2 | 0.822 |
ERK5 |
0.824 | 0.021 | 1 | 0.831 |
WNK3 |
0.824 | 0.009 | 1 | 0.861 |
AKT2 |
0.823 | 0.131 | -3 | 0.772 |
MYLK4 |
0.823 | 0.142 | -2 | 0.802 |
NEK6 |
0.823 | -0.054 | -2 | 0.799 |
PAK6 |
0.822 | 0.110 | -2 | 0.749 |
CHAK2 |
0.822 | -0.012 | -1 | 0.873 |
PKACA |
0.822 | 0.147 | -2 | 0.663 |
DCAMKL1 |
0.821 | 0.139 | -3 | 0.865 |
GRK1 |
0.821 | 0.002 | -2 | 0.715 |
RIPK3 |
0.820 | -0.037 | 3 | 0.708 |
CAMK1G |
0.820 | 0.153 | -3 | 0.819 |
PKCB |
0.820 | 0.055 | 2 | 0.713 |
FAM20C |
0.820 | 0.076 | 2 | 0.695 |
CAMK1D |
0.820 | 0.166 | -3 | 0.777 |
PAK2 |
0.819 | 0.092 | -2 | 0.793 |
HIPK2 |
0.819 | 0.111 | 1 | 0.614 |
PKCA |
0.819 | 0.051 | 2 | 0.709 |
PHKG1 |
0.819 | 0.055 | -3 | 0.881 |
NEK7 |
0.818 | -0.100 | -3 | 0.811 |
ATM |
0.818 | 0.050 | 1 | 0.837 |
SRPK3 |
0.818 | 0.073 | -3 | 0.776 |
HIPK1 |
0.818 | 0.123 | 1 | 0.723 |
PIM2 |
0.818 | 0.111 | -3 | 0.823 |
ULK1 |
0.817 | -0.105 | -3 | 0.784 |
MASTL |
0.817 | -0.111 | -2 | 0.762 |
KIS |
0.817 | 0.012 | 1 | 0.706 |
AKT1 |
0.816 | 0.143 | -3 | 0.797 |
GRK5 |
0.816 | -0.140 | -3 | 0.831 |
PKCG |
0.816 | 0.022 | 2 | 0.723 |
DNAPK |
0.816 | 0.076 | 1 | 0.797 |
RIPK1 |
0.816 | -0.051 | 1 | 0.856 |
CDK8 |
0.815 | 0.013 | 1 | 0.680 |
AURA |
0.815 | 0.095 | -2 | 0.682 |
CDK7 |
0.815 | 0.028 | 1 | 0.680 |
PKCZ |
0.814 | 0.033 | 2 | 0.771 |
IRE1 |
0.813 | -0.036 | 1 | 0.825 |
GRK6 |
0.813 | -0.069 | 1 | 0.857 |
MLK2 |
0.813 | -0.060 | 2 | 0.817 |
DYRK1A |
0.813 | 0.095 | 1 | 0.748 |
NEK9 |
0.813 | -0.086 | 2 | 0.829 |
DLK |
0.812 | -0.111 | 1 | 0.872 |
MLK1 |
0.812 | -0.122 | 2 | 0.799 |
NEK2 |
0.811 | 0.018 | 2 | 0.807 |
SNRK |
0.811 | 0.060 | 2 | 0.705 |
PKCH |
0.811 | 0.022 | 2 | 0.701 |
ANKRD3 |
0.811 | -0.066 | 1 | 0.904 |
BMPR1B |
0.811 | 0.054 | 1 | 0.802 |
CDK19 |
0.811 | 0.016 | 1 | 0.640 |
TGFBR1 |
0.810 | 0.021 | -2 | 0.757 |
CAMK1A |
0.810 | 0.187 | -3 | 0.747 |
ALK4 |
0.810 | -0.012 | -2 | 0.788 |
DYRK4 |
0.810 | 0.082 | 1 | 0.626 |
HIPK3 |
0.809 | 0.095 | 1 | 0.735 |
JNK2 |
0.809 | 0.053 | 1 | 0.630 |
DYRK1B |
0.809 | 0.092 | 1 | 0.656 |
DCAMKL2 |
0.809 | 0.091 | -3 | 0.877 |
PKR |
0.809 | -0.018 | 1 | 0.869 |
GRK7 |
0.809 | 0.021 | 1 | 0.778 |
MAPKAPK5 |
0.809 | 0.010 | -3 | 0.786 |
DYRK3 |
0.808 | 0.111 | 1 | 0.730 |
CDK5 |
0.807 | 0.034 | 1 | 0.697 |
IRE2 |
0.807 | -0.023 | 2 | 0.740 |
AKT3 |
0.807 | 0.135 | -3 | 0.722 |
TLK2 |
0.807 | -0.016 | 1 | 0.864 |
WNK4 |
0.807 | 0.035 | -2 | 0.851 |
PKCT |
0.806 | 0.051 | 2 | 0.713 |
TTBK2 |
0.806 | -0.121 | 2 | 0.734 |
SGK1 |
0.806 | 0.133 | -3 | 0.706 |
PLK1 |
0.806 | -0.086 | -2 | 0.725 |
VRK2 |
0.805 | -0.060 | 1 | 0.896 |
P70S6K |
0.805 | 0.069 | -3 | 0.787 |
PAK5 |
0.805 | 0.095 | -2 | 0.684 |
CDK13 |
0.805 | 0.001 | 1 | 0.651 |
GRK4 |
0.805 | -0.140 | -2 | 0.764 |
MLK3 |
0.805 | -0.076 | 2 | 0.728 |
P38A |
0.805 | 0.039 | 1 | 0.721 |
CDK18 |
0.805 | 0.024 | 1 | 0.602 |
SMMLCK |
0.804 | 0.093 | -3 | 0.867 |
JNK3 |
0.804 | 0.036 | 1 | 0.658 |
MEK1 |
0.804 | -0.067 | 2 | 0.857 |
CHAK1 |
0.804 | -0.053 | 2 | 0.786 |
PHKG2 |
0.804 | 0.052 | -3 | 0.864 |
SMG1 |
0.804 | -0.008 | 1 | 0.842 |
PLK3 |
0.804 | -0.031 | 2 | 0.815 |
DAPK3 |
0.804 | 0.141 | -3 | 0.860 |
CDK9 |
0.803 | 0.009 | 1 | 0.660 |
BRAF |
0.802 | -0.004 | -4 | 0.848 |
PASK |
0.802 | 0.044 | -3 | 0.890 |
CDK1 |
0.802 | 0.015 | 1 | 0.631 |
PLK4 |
0.801 | -0.033 | 2 | 0.669 |
PAK4 |
0.801 | 0.090 | -2 | 0.693 |
ROCK2 |
0.801 | 0.158 | -3 | 0.866 |
YSK4 |
0.801 | -0.097 | 1 | 0.824 |
MPSK1 |
0.800 | 0.068 | 1 | 0.804 |
CDK12 |
0.800 | 0.010 | 1 | 0.626 |
GSK3A |
0.800 | -0.023 | 4 | 0.262 |
GSK3B |
0.800 | -0.051 | 4 | 0.256 |
P38B |
0.799 | 0.039 | 1 | 0.645 |
ALK2 |
0.799 | -0.022 | -2 | 0.758 |
MAK |
0.799 | 0.119 | -2 | 0.704 |
P38G |
0.799 | 0.033 | 1 | 0.545 |
MRCKA |
0.798 | 0.130 | -3 | 0.829 |
PKCI |
0.798 | 0.038 | 2 | 0.733 |
SBK |
0.798 | 0.117 | -3 | 0.667 |
MRCKB |
0.798 | 0.128 | -3 | 0.819 |
NEK5 |
0.798 | 0.005 | 1 | 0.879 |
PRP4 |
0.798 | 0.027 | -3 | 0.773 |
CHK2 |
0.797 | 0.100 | -3 | 0.731 |
LKB1 |
0.797 | 0.068 | -3 | 0.837 |
MST3 |
0.797 | 0.001 | 2 | 0.819 |
IRAK4 |
0.797 | -0.020 | 1 | 0.842 |
DRAK1 |
0.797 | -0.045 | 1 | 0.800 |
ACVR2A |
0.797 | -0.042 | -2 | 0.730 |
PKCE |
0.797 | 0.054 | 2 | 0.702 |
PKN1 |
0.797 | 0.071 | -3 | 0.807 |
DAPK1 |
0.796 | 0.110 | -3 | 0.841 |
ERK1 |
0.796 | 0.012 | 1 | 0.637 |
MEKK1 |
0.795 | -0.066 | 1 | 0.871 |
TLK1 |
0.795 | -0.047 | -2 | 0.775 |
CDK17 |
0.795 | 0.011 | 1 | 0.547 |
ACVR2B |
0.795 | -0.043 | -2 | 0.742 |
MLK4 |
0.795 | -0.119 | 2 | 0.719 |
TAO3 |
0.794 | -0.015 | 1 | 0.839 |
CDK2 |
0.794 | -0.007 | 1 | 0.715 |
CDK14 |
0.793 | 0.022 | 1 | 0.652 |
CDK10 |
0.793 | 0.039 | 1 | 0.637 |
ZAK |
0.793 | -0.101 | 1 | 0.840 |
MEK5 |
0.793 | -0.138 | 2 | 0.828 |
BUB1 |
0.793 | 0.132 | -5 | 0.832 |
CDK3 |
0.792 | 0.033 | 1 | 0.565 |
PERK |
0.792 | -0.117 | -2 | 0.765 |
HRI |
0.792 | -0.119 | -2 | 0.793 |
GRK2 |
0.792 | -0.064 | -2 | 0.670 |
DMPK1 |
0.791 | 0.164 | -3 | 0.832 |
PINK1 |
0.791 | -0.116 | 1 | 0.839 |
PKG1 |
0.791 | 0.107 | -2 | 0.630 |
MEKK2 |
0.791 | -0.069 | 2 | 0.801 |
MOK |
0.790 | 0.100 | 1 | 0.742 |
ERK2 |
0.790 | -0.019 | 1 | 0.679 |
BMPR1A |
0.789 | 0.006 | 1 | 0.777 |
GCK |
0.788 | 0.033 | 1 | 0.861 |
CDK16 |
0.788 | 0.017 | 1 | 0.562 |
PDK1 |
0.788 | 0.019 | 1 | 0.837 |
CRIK |
0.788 | 0.132 | -3 | 0.795 |
CAMKK2 |
0.787 | -0.040 | -2 | 0.693 |
P38D |
0.787 | 0.025 | 1 | 0.571 |
TNIK |
0.786 | 0.024 | 3 | 0.869 |
MEKK3 |
0.786 | -0.161 | 1 | 0.854 |
CK1E |
0.786 | -0.053 | -3 | 0.477 |
MEKK6 |
0.786 | -0.003 | 1 | 0.855 |
ROCK1 |
0.786 | 0.139 | -3 | 0.833 |
GAK |
0.786 | 0.004 | 1 | 0.849 |
KHS1 |
0.785 | 0.073 | 1 | 0.846 |
NEK4 |
0.785 | -0.019 | 1 | 0.853 |
CAMKK1 |
0.785 | -0.112 | -2 | 0.692 |
IRAK1 |
0.784 | -0.102 | -1 | 0.760 |
TAO2 |
0.784 | -0.053 | 2 | 0.840 |
HPK1 |
0.784 | 0.029 | 1 | 0.850 |
HGK |
0.784 | -0.003 | 3 | 0.860 |
MAP3K15 |
0.783 | 0.007 | 1 | 0.823 |
NEK11 |
0.783 | -0.098 | 1 | 0.855 |
NEK8 |
0.783 | -0.086 | 2 | 0.809 |
NEK1 |
0.782 | 0.023 | 1 | 0.850 |
KHS2 |
0.782 | 0.057 | 1 | 0.857 |
PBK |
0.782 | 0.053 | 1 | 0.775 |
MINK |
0.782 | -0.016 | 1 | 0.859 |
LOK |
0.781 | 0.000 | -2 | 0.721 |
ERK7 |
0.780 | 0.008 | 2 | 0.543 |
LRRK2 |
0.779 | -0.048 | 2 | 0.850 |
JNK1 |
0.779 | 0.004 | 1 | 0.600 |
CK1G1 |
0.779 | -0.069 | -3 | 0.459 |
MST2 |
0.779 | -0.055 | 1 | 0.866 |
EEF2K |
0.777 | -0.056 | 3 | 0.839 |
GRK3 |
0.777 | -0.074 | -2 | 0.632 |
TAK1 |
0.777 | -0.055 | 1 | 0.886 |
CK2A2 |
0.776 | 0.003 | 1 | 0.667 |
TTBK1 |
0.776 | -0.125 | 2 | 0.660 |
CK1D |
0.776 | -0.055 | -3 | 0.424 |
CDK4 |
0.776 | -0.001 | 1 | 0.609 |
CDK6 |
0.776 | 0.001 | 1 | 0.632 |
PLK2 |
0.775 | -0.040 | -3 | 0.731 |
VRK1 |
0.775 | -0.055 | 2 | 0.838 |
CK1A2 |
0.775 | -0.050 | -3 | 0.427 |
YSK1 |
0.773 | -0.031 | 2 | 0.793 |
SLK |
0.773 | -0.048 | -2 | 0.649 |
MST1 |
0.773 | -0.048 | 1 | 0.849 |
STK33 |
0.773 | -0.088 | 2 | 0.657 |
PDHK3_TYR |
0.770 | 0.147 | 4 | 0.584 |
HASPIN |
0.768 | 0.026 | -1 | 0.744 |
NEK3 |
0.768 | -0.072 | 1 | 0.822 |
MEK2 |
0.767 | -0.130 | 2 | 0.822 |
CK2A1 |
0.766 | -0.021 | 1 | 0.645 |
RIPK2 |
0.763 | -0.160 | 1 | 0.804 |
TESK1_TYR |
0.762 | 0.036 | 3 | 0.897 |
LIMK2_TYR |
0.761 | 0.080 | -3 | 0.911 |
MYO3B |
0.761 | -0.027 | 2 | 0.814 |
ASK1 |
0.760 | -0.029 | 1 | 0.805 |
PDHK4_TYR |
0.760 | 0.046 | 2 | 0.900 |
BIKE |
0.759 | 0.009 | 1 | 0.720 |
PKMYT1_TYR |
0.759 | 0.005 | 3 | 0.845 |
OSR1 |
0.758 | -0.087 | 2 | 0.803 |
MAP2K4_TYR |
0.757 | -0.048 | -1 | 0.886 |
MAP2K7_TYR |
0.757 | -0.018 | 2 | 0.877 |
TTK |
0.757 | -0.071 | -2 | 0.746 |
TAO1 |
0.757 | -0.053 | 1 | 0.786 |
YANK3 |
0.755 | -0.048 | 2 | 0.460 |
MAP2K6_TYR |
0.754 | -0.076 | -1 | 0.893 |
MYO3A |
0.752 | -0.067 | 1 | 0.837 |
PDHK1_TYR |
0.751 | -0.060 | -1 | 0.886 |
RET |
0.751 | -0.037 | 1 | 0.847 |
TNNI3K_TYR |
0.751 | 0.104 | 1 | 0.867 |
BMPR2_TYR |
0.750 | -0.068 | -1 | 0.861 |
PINK1_TYR |
0.749 | -0.132 | 1 | 0.852 |
LIMK1_TYR |
0.749 | -0.050 | 2 | 0.863 |
AAK1 |
0.748 | 0.046 | 1 | 0.613 |
DDR1 |
0.748 | -0.035 | 4 | 0.528 |
EPHA6 |
0.747 | -0.008 | -1 | 0.827 |
ALPHAK3 |
0.746 | -0.101 | -1 | 0.775 |
TYK2 |
0.746 | -0.074 | 1 | 0.851 |
ROS1 |
0.745 | -0.034 | 3 | 0.758 |
TYRO3 |
0.744 | -0.063 | 3 | 0.786 |
EPHB4 |
0.744 | -0.032 | -1 | 0.807 |
JAK2 |
0.743 | -0.067 | 1 | 0.851 |
MST1R |
0.743 | -0.087 | 3 | 0.779 |
CK1A |
0.742 | -0.073 | -3 | 0.325 |
TNK1 |
0.742 | 0.015 | 3 | 0.764 |
STLK3 |
0.740 | -0.119 | 1 | 0.810 |
ABL2 |
0.740 | -0.027 | -1 | 0.780 |
NEK10_TYR |
0.739 | -0.026 | 1 | 0.721 |
CSF1R |
0.738 | -0.084 | 3 | 0.756 |
JAK3 |
0.737 | -0.093 | 1 | 0.823 |
TNK2 |
0.737 | -0.047 | 3 | 0.702 |
DDR2 |
0.736 | 0.024 | 3 | 0.695 |
FGR |
0.736 | -0.084 | 1 | 0.872 |
INSRR |
0.735 | -0.094 | 3 | 0.726 |
ABL1 |
0.735 | -0.039 | -1 | 0.771 |
PDGFRB |
0.734 | -0.105 | 3 | 0.777 |
TXK |
0.733 | -0.023 | 1 | 0.838 |
FER |
0.733 | -0.117 | 1 | 0.879 |
JAK1 |
0.733 | -0.033 | 1 | 0.806 |
FGFR2 |
0.732 | -0.111 | 3 | 0.767 |
EPHA4 |
0.732 | -0.067 | 2 | 0.817 |
EPHB1 |
0.732 | -0.079 | 1 | 0.878 |
YES1 |
0.731 | -0.095 | -1 | 0.807 |
EPHB3 |
0.731 | -0.069 | -1 | 0.784 |
ITK |
0.731 | -0.080 | -1 | 0.746 |
FGFR1 |
0.730 | -0.079 | 3 | 0.737 |
AXL |
0.729 | -0.095 | 3 | 0.744 |
KDR |
0.729 | -0.095 | 3 | 0.713 |
SRMS |
0.729 | -0.112 | 1 | 0.867 |
EPHB2 |
0.728 | -0.071 | -1 | 0.775 |
KIT |
0.727 | -0.132 | 3 | 0.754 |
TEK |
0.727 | -0.108 | 3 | 0.706 |
ALK |
0.726 | -0.086 | 3 | 0.686 |
LCK |
0.726 | -0.069 | -1 | 0.767 |
HCK |
0.726 | -0.113 | -1 | 0.767 |
FLT3 |
0.725 | -0.151 | 3 | 0.768 |
PDGFRA |
0.725 | -0.156 | 3 | 0.773 |
MERTK |
0.725 | -0.099 | 3 | 0.745 |
BLK |
0.725 | -0.026 | -1 | 0.777 |
MET |
0.724 | -0.119 | 3 | 0.746 |
BMX |
0.724 | -0.065 | -1 | 0.662 |
LTK |
0.723 | -0.097 | 3 | 0.703 |
EPHA7 |
0.721 | -0.085 | 2 | 0.816 |
WEE1_TYR |
0.721 | -0.110 | -1 | 0.737 |
INSR |
0.721 | -0.114 | 3 | 0.698 |
PTK6 |
0.721 | -0.155 | -1 | 0.694 |
TEC |
0.720 | -0.101 | -1 | 0.681 |
EPHA1 |
0.720 | -0.096 | 3 | 0.713 |
NTRK1 |
0.719 | -0.178 | -1 | 0.808 |
EPHA3 |
0.719 | -0.122 | 2 | 0.793 |
BTK |
0.717 | -0.177 | -1 | 0.703 |
FGFR3 |
0.717 | -0.135 | 3 | 0.731 |
YANK2 |
0.717 | -0.082 | 2 | 0.473 |
PTK2B |
0.716 | -0.068 | -1 | 0.738 |
NTRK2 |
0.715 | -0.166 | 3 | 0.719 |
CK1G3 |
0.714 | -0.094 | -3 | 0.278 |
NTRK3 |
0.714 | -0.133 | -1 | 0.761 |
FYN |
0.714 | -0.078 | -1 | 0.745 |
FLT1 |
0.714 | -0.159 | -1 | 0.805 |
FLT4 |
0.713 | -0.169 | 3 | 0.710 |
MATK |
0.713 | -0.112 | -1 | 0.725 |
ERBB2 |
0.712 | -0.178 | 1 | 0.784 |
FRK |
0.712 | -0.124 | -1 | 0.772 |
EPHA5 |
0.711 | -0.109 | 2 | 0.805 |
CSK |
0.709 | -0.132 | 2 | 0.816 |
LYN |
0.709 | -0.132 | 3 | 0.674 |
EGFR |
0.707 | -0.111 | 1 | 0.692 |
EPHA8 |
0.706 | -0.119 | -1 | 0.757 |
FGFR4 |
0.704 | -0.121 | -1 | 0.743 |
PTK2 |
0.704 | -0.058 | -1 | 0.746 |
SRC |
0.703 | -0.128 | -1 | 0.749 |
IGF1R |
0.702 | -0.137 | 3 | 0.639 |
EPHA2 |
0.698 | -0.124 | -1 | 0.716 |
SYK |
0.697 | -0.098 | -1 | 0.731 |
MUSK |
0.694 | -0.148 | 1 | 0.681 |
ERBB4 |
0.691 | -0.111 | 1 | 0.706 |
CK1G2 |
0.690 | -0.113 | -3 | 0.374 |
FES |
0.679 | -0.166 | -1 | 0.649 |
ZAP70 |
0.678 | -0.096 | -1 | 0.677 |