Motif 848 (n=160)

Position-wise Probabilities
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uniprot genes site source protein function
A0A1W2PPC1 PRR33 S280 ochoa Proline rich 33 None
A4UGR9 XIRP2 S3042 ochoa Xin actin-binding repeat-containing protein 2 (Beta-xin) (Cardiomyopathy-associated protein 3) (Xeplin) Protects actin filaments from depolymerization (PubMed:15454575). Required for correct morphology of cell membranes and maturation of intercalated disks of cardiomyocytes via facilitating localization of XIRP1 and CDH2 to the termini of aligned mature cardiomyocytes (By similarity). Thereby required for correct postnatal heart development and growth regulation that is crucial for overall heart morphology and diastolic function (By similarity). Required for normal electrical conduction in the heart including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with the cardiac ion channel components Scn5a/Nav1.5 and Kcna5/Kv1.5 (By similarity). Required for regular actin filament spacing of the paracrystalline array in both inner and outer hair cells of the cochlea, thereby required for maintenance of stereocilia morphology (By similarity). {ECO:0000250|UniProtKB:Q4U4S6, ECO:0000269|PubMed:15454575}.
A6NMY6 ANXA2P2 S117 ochoa Putative annexin A2-like protein (Annexin A2 pseudogene 2) (Lipocortin II pseudogene) Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. {ECO:0000250}.
A8MZF0 PRR33 S132 ochoa Proline-rich protein 33 None
O14646 CHD1 S90 ochoa Chromodomain-helicase-DNA-binding protein 1 (CHD-1) (EC 3.6.4.-) (ATP-dependent helicase CHD1) ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3 (PubMed:18042460, PubMed:28866611). Required for maintaining open chromatin and pluripotency in embryonic stem cells (By similarity). {ECO:0000250|UniProtKB:P40201, ECO:0000269|PubMed:18042460, ECO:0000269|PubMed:28866611}.
O14686 KMT2D S2269 ochoa Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}.
O14976 GAK S1029 ochoa Cyclin-G-associated kinase (EC 2.7.11.1) (DnaJ homolog subfamily C member 26) Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 (PubMed:10625686). May play a role in clathrin-mediated endocytosis and intracellular trafficking, and in the dynamics of clathrin assembly/disassembly (PubMed:18489706). {ECO:0000269|PubMed:10625686, ECO:0000269|PubMed:18489706}.
O15014 ZNF609 S1055 ochoa Zinc finger protein 609 Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others. {ECO:0000250|UniProtKB:Q8BZ47}.; FUNCTION: [Isoform 2]: Involved in the regulation of myoblast proliferation during myogenesis. {ECO:0000269|PubMed:28344082}.
O43683 BUB1 S602 ochoa Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (PubMed:35044816). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:17158872, ECO:0000269|PubMed:19487456, ECO:0000269|PubMed:20739936, ECO:0000269|PubMed:35044816}.
O60244 MED14 S995 ochoa Mediator of RNA polymerase II transcription subunit 14 (Activator-recruited cofactor 150 kDa component) (ARC150) (Cofactor required for Sp1 transcriptional activation subunit 2) (CRSP complex subunit 2) (Mediator complex subunit 14) (RGR1 homolog) (hRGR1) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150) Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:15340088, ECO:0000269|PubMed:15625066, ECO:0000269|PubMed:16595664}.
O60353 FZD6 S683 ochoa Frizzled-6 (Fz-6) (hFz6) Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear (By similarity). {ECO:0000250|UniProtKB:Q61089}.
O60706 ABCC9 S658 ochoa ATP-binding cassette sub-family C member 9 (Sulfonylurea receptor 2) Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation (PubMed:9831708). Can form a sulfonylurea-sensitive but ATP-insensitive potassium channel with KCNJ8 (By similarity). {ECO:0000250|UniProtKB:P70170, ECO:0000269|PubMed:9831708}.
O75037 KIF21B S1167 ochoa Kinesin-like protein KIF21B Plus-end directed microtubule-dependent motor protein which displays processive activity. Is involved in regulation of microtubule dynamics, synapse function and neuronal morphology, including dendritic tree branching and spine formation. Plays a role in lerning and memory. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptor to cell surface. {ECO:0000250|UniProtKB:Q9QXL1}.
O75376 NCOR1 S2084 ochoa Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}.
O94885 SASH1 S839 ochoa SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). {ECO:0000269|PubMed:23333244, ECO:0000269|PubMed:23776175, ECO:0000269|PubMed:25315659}.
O94915 FRYL S479 ochoa Protein furry homolog-like (ALL1-fused gene from chromosome 4p12 protein) Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching (By similarity). May function as a transcriptional activator. {ECO:0000250, ECO:0000269|PubMed:16061630}.
O95071 UBR5 S621 ochoa E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250|UniProtKB:Q80TP3, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:28689657, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:33208877, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37478862}.
O95271 TNKS S991 psp Poly [ADP-ribose] polymerase tankyrase-1 (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 5) (ARTD5) (Poly [ADP-ribose] polymerase 5A) (Protein poly-ADP-ribosyltransferase tankyrase-1) (EC 2.4.2.-) (TNKS-1) (TRF1-interacting ankyrin-related ADP-ribose polymerase) (Tankyrase I) (Tankyrase-1) (TANK1) Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking (PubMed:10988299, PubMed:11739745, PubMed:16076287, PubMed:19759537, PubMed:21478859, PubMed:22864114, PubMed:23622245, PubMed:25043379, PubMed:28619731). Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation (PubMed:19759537, PubMed:21478859). Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination (PubMed:21478859). Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length (PubMed:11739745). Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI (PubMed:22864114). May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles (PubMed:10988299). May be involved in spindle pole assembly through PARsylation of NUMA1 (PubMed:16076287). Stimulates 26S proteasome activity (PubMed:23622245). {ECO:0000269|PubMed:10988299, ECO:0000269|PubMed:11739745, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:19759537, ECO:0000269|PubMed:21478859, ECO:0000269|PubMed:22864114, ECO:0000269|PubMed:23622245, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:28619731}.
O95833 CLIC3 S49 ochoa Chloride intracellular channel protein 3 (Glutaredoxin-like oxidoreductase CLIC3) (EC 1.8.-.-) In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor (PubMed:28198360, PubMed:37759794). Reduced in a glutathione-dependent way and secreted into the extracellular matrix where it activates TGM2 and promotes blood vessel growth during tissue remodeling as occurs in tumorigenesis. Can reduce specific cysteines in TGM2 and regulate cofactor binding (PubMed:28198360). Can insert into membranes and form outwardly rectifying chloride ion channels. May participate in cellular growth control. {ECO:0000269|PubMed:28198360, ECO:0000269|PubMed:32066374, ECO:0000269|PubMed:37759794, ECO:0000269|PubMed:9880541}.
P06733 ENO1 S272 ochoa Alpha-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (C-myc promoter-binding protein) (Enolase 1) (MBP-1) (MPB-1) (Non-neural enolase) (NNE) (Phosphopyruvate hydratase) (Plasminogen-binding protein) Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (PubMed:1369209, PubMed:29775581). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses (PubMed:10802057, PubMed:12666133, PubMed:2005901, PubMed:29775581). May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (PubMed:12666133). Stimulates immunoglobulin production (PubMed:1369209). {ECO:0000269|PubMed:10802057, ECO:0000269|PubMed:12666133, ECO:0000269|PubMed:1369209, ECO:0000269|PubMed:2005901, ECO:0000269|PubMed:29775581}.; FUNCTION: [Isoform MBP-1]: Binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor. {ECO:0000269|PubMed:10082554}.
P07355 ANXA2 S117 ochoa Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36) Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:22848640, PubMed:24808179). Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation (By similarity). Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis (By similarity). {ECO:0000250|UniProtKB:P07356, ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22848640, ECO:0000269|PubMed:24808179}.; FUNCTION: (Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen. {ECO:0000269|PubMed:25139904}.
P08574 CYC1 S103 ochoa Cytochrome c1, heme protein, mitochondrial (EC 7.1.1.8) (Complex III subunit 4) (Complex III subunit IV) (Cytochrome b-c1 complex subunit 4) (Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit) (Cytochrome c-1) Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. Cytochrome c1 is a catalytic core subunit containing a c-type heme. It transfers electrons from the [2Fe-2S] iron-sulfur cluster of the Rieske protein to cytochrome c. {ECO:0000250|UniProtKB:P07143}.
P08684 CYP3A4 S478 psp Cytochrome P450 3A4 (EC 1.14.14.1) (1,4-cineole 2-exo-monooxygenase) (1,8-cineole 2-exo-monooxygenase) (EC 1.14.14.56) (Albendazole monooxygenase (sulfoxide-forming)) (EC 1.14.14.73) (Albendazole sulfoxidase) (CYPIIIA3) (CYPIIIA4) (Cholesterol 25-hydroxylase) (Cytochrome P450 3A3) (Cytochrome P450 HLp) (Cytochrome P450 NF-25) (Cytochrome P450-PCN1) (Nifedipine oxidase) (Quinine 3-monooxygenase) (EC 1.14.14.55) A cytochrome P450 monooxygenase involved in the metabolism of sterols, steroid hormones, retinoids and fatty acids (PubMed:10681376, PubMed:11093772, PubMed:11555828, PubMed:12865317, PubMed:14559847, PubMed:15373842, PubMed:15764715, PubMed:19965576, PubMed:20702771, PubMed:21490593, PubMed:21576599). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds (PubMed:12865317, PubMed:14559847, PubMed:15373842, PubMed:15764715, PubMed:21490593, PubMed:21576599, PubMed:2732228). Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C-16 position (PubMed:11555828, PubMed:12865317, PubMed:14559847). Plays a role in the metabolism of androgens, particularly in oxidative deactivation of testosterone (PubMed:15373842, PubMed:15764715, PubMed:22773874, PubMed:2732228). Metabolizes testosterone to less biologically active 2beta- and 6beta-hydroxytestosterones (PubMed:15373842, PubMed:15764715, PubMed:2732228). Contributes to the formation of hydroxycholesterols (oxysterols), particularly A-ring hydroxylated cholesterol at the C-4beta position, and side chain hydroxylated cholesterol at the C-25 position, likely contributing to cholesterol degradation and bile acid biosynthesis (PubMed:21576599). Catalyzes bisallylic hydroxylation of polyunsaturated fatty acids (PUFA) (PubMed:9435160). Catalyzes the epoxidation of double bonds of PUFA with a preference for the last double bond (PubMed:19965576). Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling (PubMed:20702771). Plays a role in the metabolism of retinoids. Displays high catalytic activity for oxidation of all-trans-retinol to all-trans-retinal, a rate-limiting step for the biosynthesis of all-trans-retinoic acid (atRA) (PubMed:10681376). Further metabolizes atRA toward 4-hydroxyretinoate and may play a role in hepatic atRA clearance (PubMed:11093772). Responsible for oxidative metabolism of xenobiotics. Acts as a 2-exo-monooxygenase for plant lipid 1,8-cineole (eucalyptol) (PubMed:11159812). Metabolizes the majority of the administered drugs. Catalyzes sulfoxidation of the anthelmintics albendazole and fenbendazole (PubMed:10759686). Hydroxylates antimalarial drug quinine (PubMed:8968357). Acts as a 1,4-cineole 2-exo-monooxygenase (PubMed:11695850). Also involved in vitamin D catabolism and calcium homeostasis. Catalyzes the inactivation of the active hormone calcitriol (1-alpha,25-dihydroxyvitamin D(3)) (PubMed:29461981). {ECO:0000269|PubMed:10681376, ECO:0000269|PubMed:10759686, ECO:0000269|PubMed:11093772, ECO:0000269|PubMed:11159812, ECO:0000269|PubMed:11555828, ECO:0000269|PubMed:11695850, ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:14559847, ECO:0000269|PubMed:15373842, ECO:0000269|PubMed:15764715, ECO:0000269|PubMed:19965576, ECO:0000269|PubMed:20702771, ECO:0000269|PubMed:21490593, ECO:0000269|PubMed:21576599, ECO:0000269|PubMed:22773874, ECO:0000269|PubMed:2732228, ECO:0000269|PubMed:29461981, ECO:0000269|PubMed:8968357, ECO:0000269|PubMed:9435160}.
P19484 TFEB S74 ochoa Transcription factor EB (Class E basic helix-loop-helix protein 35) (bHLHe35) Transcription factor that acts as a master regulator of lysosomal biogenesis, autophagy, lysosomal exocytosis, lipid catabolism, energy metabolism and immune response (PubMed:21617040, PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:30120233, PubMed:31672913, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823, PubMed:36749723, PubMed:37079666). Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF (PubMed:1748288, PubMed:19556463, PubMed:29146937). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFEB phosphorylation by MTOR promotes its cytosolic retention and subsequent inactivation (PubMed:21617040, PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823). Upon starvation or lysosomal stress, inhibition of MTOR induces TFEB dephosphorylation, resulting in nuclear localization and transcription factor activity (PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823). Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression, thereby playing a central role in expression of lysosomal genes (PubMed:19556463, PubMed:22692423). Regulates lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937). Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy (PubMed:21617040, PubMed:22576015, PubMed:23434374, PubMed:27278822). In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer (PubMed:2115126). Plays a role in the signal transduction processes required for normal vascularization of the placenta (By similarity). Involved in the immune response to infection by the bacteria S.aureus, S.typhimurium or S.enterica: infection promotes itaconate production, leading to alkylation, resulting in nuclear localization and transcription factor activity (PubMed:35662396). Itaconate-mediated alkylation activates TFEB-dependent lysosomal biogenesis, facilitating the bacteria clearance during the antibacterial innate immune response (PubMed:35662396). In association with ACSS2, promotes the expression of genes involved in lysosome biogenesis and both autophagy upon glucose deprivation (PubMed:28552616). {ECO:0000250|UniProtKB:Q9R210, ECO:0000269|PubMed:1748288, ECO:0000269|PubMed:19556463, ECO:0000269|PubMed:2115126, ECO:0000269|PubMed:21617040, ECO:0000269|PubMed:22343943, ECO:0000269|PubMed:22576015, ECO:0000269|PubMed:22692423, ECO:0000269|PubMed:23434374, ECO:0000269|PubMed:25720963, ECO:0000269|PubMed:27278822, ECO:0000269|PubMed:28552616, ECO:0000269|PubMed:29146937, ECO:0000269|PubMed:30120233, ECO:0000269|PubMed:31672913, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:32753672, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:36697823, ECO:0000269|PubMed:36749723, ECO:0000269|PubMed:37079666}.
P20810 CAST S507 ochoa Calpastatin (Calpain inhibitor) (Sperm BS-17 component) Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.
P25445 FAS S225 ochoa Tumor necrosis factor receptor superfamily member 6 (Apo-1 antigen) (Apoptosis-mediating surface antigen FAS) (FASLG receptor) (CD antigen CD95) Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase CASP8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs CASP8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). {ECO:0000269|PubMed:19118384, ECO:0000269|PubMed:7533181, ECO:0000269|PubMed:9184224}.
P28290 ITPRID2 S1138 ochoa Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) None
P30086 PEBP1 S54 ochoa Phosphatidylethanolamine-binding protein 1 (PEBP-1) (HCNPpp) (Neuropolypeptide h3) (Prostatic-binding protein) (Raf kinase inhibitor protein) (RKIP) [Cleaved into: Hippocampal cholinergic neurostimulating peptide (HCNP)] Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation. {ECO:0000250, ECO:0000269|PubMed:18294816}.; FUNCTION: HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity). {ECO:0000250}.
P35269 GTF2F1 S398 ochoa General transcription factor IIF subunit 1 (General transcription factor IIF 74 kDa subunit) (Transcription initiation factor IIF subunit alpha) (TFIIF-alpha) (Transcription initiation factor RAP74) TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. {ECO:0000269|PubMed:10428810}.
P35269 GTF2F1 S449 ochoa General transcription factor IIF subunit 1 (General transcription factor IIF 74 kDa subunit) (Transcription initiation factor IIF subunit alpha) (TFIIF-alpha) (Transcription initiation factor RAP74) TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. {ECO:0000269|PubMed:10428810}.
P35869 AHR S68 psp Aryl hydrocarbon receptor (Ah receptor) (AhR) (Class E basic helix-loop-helix protein 76) (bHLHe76) Ligand-activated transcription factor that enables cells to adapt to changing conditions by sensing compounds from the environment, diet, microbiome and cellular metabolism, and which plays important roles in development, immunity and cancer (PubMed:23275542, PubMed:30373764, PubMed:32818467, PubMed:7961644). Upon ligand binding, translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE) (PubMed:23275542, PubMed:30373764, PubMed:7961644). Regulates a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation (PubMed:12213388). Xenobiotics can act as ligands: upon xenobiotic-binding, activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene) (PubMed:7961644, PubMed:33193710). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons (PubMed:34521881, PubMed:7961644). Next to xenobiotics, natural ligands derived from plants, microbiota, and endogenous metabolism are potent AHR agonists (PubMed:18076143). Tryptophan (Trp) derivatives constitute an important class of endogenous AHR ligands (PubMed:32818467, PubMed:32866000). Acts as a negative regulator of anti-tumor immunity: indoles and kynurenic acid generated by Trp catabolism act as ligand and activate AHR, thereby promoting AHR-driven cancer cell motility and suppressing adaptive immunity (PubMed:32818467). Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1 (PubMed:28602820). Inhibits PER1 by repressing the CLOCK-BMAL1 heterodimer mediated transcriptional activation of PER1 (PubMed:28602820). The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28602820). {ECO:0000269|PubMed:23275542, ECO:0000269|PubMed:28602820, ECO:0000269|PubMed:30373764, ECO:0000269|PubMed:32818467, ECO:0000269|PubMed:32866000, ECO:0000269|PubMed:33193710, ECO:0000269|PubMed:34521881, ECO:0000269|PubMed:7961644, ECO:0000303|PubMed:12213388, ECO:0000303|PubMed:18076143}.
P42331 ARHGAP25 S517 ochoa Rho GTPase-activating protein 25 (Rho-type GTPase-activating protein 25) GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}.
P49790 NUP153 S607 ochoa Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}.
P49790 NUP153 S1046 ochoa Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}.
P50613 CDK7 S321 ochoa Cyclin-dependent kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (39 kDa protein kinase) (p39 Mo15) (CDK-activating kinase 1) (Cell division protein kinase 7) (Serine/threonine-protein kinase 1) (TFIIH basal transcription factor complex kinase subunit) Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription (PubMed:9852112, PubMed:19136461, PubMed:26257281, PubMed:28768201). Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201). Initiates transcription by RNA polymerase II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, PubMed:28768201). CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the CTD of POLR2A, allowing its escape from the promoter and elongation of the transcripts (PubMed:9852112). Its expression and activity are constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 activation by phosphorylation, but is inactivated in turn by p53/TP53; this feedback loop may lead to an arrest of the cell cycle and of the transcription, helping in cell recovery, or to apoptosis. Required for DNA-bound peptides-mediated transcription and cellular growth inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, ECO:0000269|PubMed:9372954, ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}.
P51587 BRCA2 S70 ochoa Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein) Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination (PubMed:24896180). {ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15199141, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:20729832, ECO:0000269|PubMed:20729858, ECO:0000269|PubMed:20729859, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21719596, ECO:0000269|PubMed:24485656, ECO:0000269|PubMed:24896180}.
P51587 BRCA2 S1099 ochoa Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein) Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination (PubMed:24896180). {ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15199141, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:20729832, ECO:0000269|PubMed:20729858, ECO:0000269|PubMed:20729859, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21719596, ECO:0000269|PubMed:24485656, ECO:0000269|PubMed:24896180}.
P52948 NUP98 S679 ochoa Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)] Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC (PubMed:33097660). May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:33097660}.; FUNCTION: (Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro) (PubMed:23523133). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro) (PubMed:23523133). {ECO:0000269|PubMed:23523133}.
P52948 NUP98 S839 ochoa Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)] Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC (PubMed:33097660). May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:33097660}.; FUNCTION: (Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro) (PubMed:23523133). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro) (PubMed:23523133). {ECO:0000269|PubMed:23523133}.
P54886 ALDH18A1 S429 ochoa Delta-1-pyrroline-5-carboxylate synthase (P5CS) (Aldehyde dehydrogenase family 18 member A1) [Includes: Glutamate 5-kinase (GK) (EC 2.7.2.11) (Gamma-glutamyl kinase); Gamma-glutamyl phosphate reductase (GPR) (EC 1.2.1.41) (Glutamate-5-semialdehyde dehydrogenase) (Glutamyl-gamma-semialdehyde dehydrogenase)] Bifunctional enzyme that converts glutamate to glutamate 5-semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine. {ECO:0000269|PubMed:10037775, ECO:0000269|PubMed:11092761, ECO:0000269|PubMed:26297558, ECO:0000269|PubMed:26320891, ECO:0000269|PubMed:39506109}.
P78559 MAP1A S579 ochoa Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements.
P78559 MAP1A S1172 ochoa Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements.
P78559 MAP1A S2261 ochoa Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements.
P80192 MAP3K9 S917 ochoa Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1) Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Also plays a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. {ECO:0000269|PubMed:11416147, ECO:0000269|PubMed:15610029}.
P98082 DAB2 S675 ochoa Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Differentially-expressed protein 2) Adapter protein that functions as a clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. May act as a tumor suppressor. {ECO:0000269|PubMed:11387212, ECO:0000269|PubMed:12805222, ECO:0000269|PubMed:16267015, ECO:0000269|PubMed:16984970, ECO:0000269|PubMed:19306879, ECO:0000269|PubMed:21995445, ECO:0000269|PubMed:22323290, ECO:0000269|PubMed:22491013}.
Q00613 HSF1 S326 ochoa|psp Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1) Functions as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones, heat shock proteins (HSPs), that protect cells from cellular insult damage (PubMed:11447121, PubMed:12659875, PubMed:12917326, PubMed:15016915, PubMed:18451878, PubMed:1871105, PubMed:1986252, PubMed:25963659, PubMed:26754925, PubMed:7623826, PubMed:7760831, PubMed:8940068, PubMed:8946918, PubMed:9121459, PubMed:9341107, PubMed:9499401, PubMed:9535852, PubMed:9727490). In unstressed cells, is present in a HSP90-containing multichaperone complex that maintains it in a non-DNA-binding inactivated monomeric form (PubMed:11583998, PubMed:16278218, PubMed:9727490). Upon exposure to heat and other stress stimuli, undergoes homotrimerization and activates HSP gene transcription through binding to site-specific heat shock elements (HSEs) present in the promoter regions of HSP genes (PubMed:10359787, PubMed:11583998, PubMed:12659875, PubMed:16278218, PubMed:1871105, PubMed:1986252, PubMed:25963659, PubMed:26754925, PubMed:7623826, PubMed:7935471, PubMed:8455624, PubMed:8940068, PubMed:9499401, PubMed:9727490). Upon heat shock stress, forms a chromatin-associated complex with TTC5/STRAP and p300/EP300 to stimulate HSR transcription, therefore increasing cell survival (PubMed:18451878). Activation is reversible, and during the attenuation and recovery phase period of the HSR, returns to its unactivated form (PubMed:11583998, PubMed:16278218). Binds to inverted 5'-NGAAN-3' pentamer DNA sequences (PubMed:1986252, PubMed:26727489). Binds to chromatin at heat shock gene promoters (PubMed:25963659). Activates transcription of transcription factor FOXR1 which in turn activates transcription of the heat shock chaperones HSPA1A and HSPA6 and the antioxidant NADPH-dependent reductase DHRS2 (PubMed:34723967). Also serves several other functions independently of its transcriptional activity. Involved in the repression of Ras-induced transcriptional activation of the c-fos gene in heat-stressed cells (PubMed:9341107). Positively regulates pre-mRNA 3'-end processing and polyadenylation of HSP70 mRNA upon heat-stressed cells in a symplekin (SYMPK)-dependent manner (PubMed:14707147). Plays a role in nuclear export of stress-induced HSP70 mRNA (PubMed:17897941). Plays a role in the regulation of mitotic progression (PubMed:18794143). Also plays a role as a negative regulator of non-homologous end joining (NHEJ) repair activity in a DNA damage-dependent manner (PubMed:26359349). Involved in stress-induced cancer cell proliferation in a IER5-dependent manner (PubMed:26754925). {ECO:0000269|PubMed:10359787, ECO:0000269|PubMed:11447121, ECO:0000269|PubMed:11583998, ECO:0000269|PubMed:12659875, ECO:0000269|PubMed:12917326, ECO:0000269|PubMed:14707147, ECO:0000269|PubMed:15016915, ECO:0000269|PubMed:16278218, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18451878, ECO:0000269|PubMed:1871105, ECO:0000269|PubMed:18794143, ECO:0000269|PubMed:1986252, ECO:0000269|PubMed:25963659, ECO:0000269|PubMed:26359349, ECO:0000269|PubMed:26727489, ECO:0000269|PubMed:26754925, ECO:0000269|PubMed:34723967, ECO:0000269|PubMed:7623826, ECO:0000269|PubMed:7760831, ECO:0000269|PubMed:7935471, ECO:0000269|PubMed:8455624, ECO:0000269|PubMed:8940068, ECO:0000269|PubMed:8946918, ECO:0000269|PubMed:9121459, ECO:0000269|PubMed:9341107, ECO:0000269|PubMed:9499401, ECO:0000269|PubMed:9535852, ECO:0000269|PubMed:9727490}.; FUNCTION: (Microbial infection) Plays a role in latent human immunodeficiency virus (HIV-1) transcriptional reactivation. Binds to the HIV-1 long terminal repeat promoter (LTR) to reactivate viral transcription by recruiting cellular transcriptional elongation factors, such as CDK9, CCNT1 and EP300. {ECO:0000269|PubMed:27189267}.
Q02446 SP4 S46 ochoa Transcription factor Sp4 (SPR-1) Binds to GT and GC boxes promoters elements. Probable transcriptional activator.
Q03164 KMT2A S1005 ochoa Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}.
Q04721 NOTCH2 S2090 ochoa Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)] Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (PubMed:21378985, PubMed:21378989). Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation (PubMed:29149593). Positively regulates self-renewal of liver cancer cells (PubMed:25985737). {ECO:0000250|UniProtKB:O35516, ECO:0000269|PubMed:21378985, ECO:0000269|PubMed:21378989, ECO:0000269|PubMed:25985737, ECO:0000269|PubMed:29149593}.
Q07960 ARHGAP1 S50 ochoa Rho GTPase-activating protein 1 (CDC42 GTPase-activating protein) (GTPase-activating protein rhoGAP) (Rho-related small GTPase protein activator) (Rho-type GTPase-activating protein 1) (p50-RhoGAP) GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate.
Q08174 PCDH1 S971 ochoa Protocadherin-1 (Cadherin-like protein 1) (Protocadherin-42) (PC42) May be involved in cell-cell interaction processes and in cell adhesion.
Q08209 PPP3CA S492 ochoa Protein phosphatase 3 catalytic subunit alpha (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calcineurin A alpha) (Calmodulin-dependent calcineurin A subunit alpha isoform) (CNA alpha) (Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform) Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:15671020, PubMed:18838687, PubMed:19154138, PubMed:23468591, PubMed:30254215). Many of the substrates contain a PxIxIT motif and/or a LxVP motif (PubMed:17498738, PubMed:17502104, PubMed:22343722, PubMed:23468591, PubMed:27974827). In response to increased Ca(2+) levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation (PubMed:15671020). In response to increased Ca(2+) levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to the mitochondrion (PubMed:18838687). Positively regulates the CACNA1B/CAV2.2-mediated Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals (By similarity). Dephosphorylates heat shock protein HSPB1 (By similarity). Dephosphorylates and activates transcription factor NFATC1 (PubMed:19154138). In response to increased Ca(2+) levels, regulates NFAT-mediated transcription probably by dephosphorylating NFAT and promoting its nuclear translocation (PubMed:26248042). Dephosphorylates and inactivates transcription factor ELK1 (PubMed:19154138). Dephosphorylates DARPP32 (PubMed:19154138). May dephosphorylate CRTC2 at 'Ser-171' resulting in CRTC2 dissociation from 14-3-3 proteins (PubMed:30611118). Dephosphorylates transcription factor TFEB at 'Ser-211' following Coxsackievirus B3 infection, promoting nuclear translocation (PubMed:33691586). Required for postnatal development of the nephrogenic zone and superficial glomeruli in the kidneys, cell cycle homeostasis in the nephrogenic zone, and ultimately normal kidney function (By similarity). Plays a role in intracellular AQP2 processing and localization to the apical membrane in the kidney, may thereby be required for efficient kidney filtration (By similarity). Required for secretion of salivary enzymes amylase, peroxidase, lysozyme and sialic acid via formation of secretory vesicles in the submandibular glands (By similarity). Required for calcineurin activity and homosynaptic depotentiation in the hippocampus (By similarity). Required for normal differentiation and survival of keratinocytes and therefore required for epidermis superstructure formation (By similarity). Positively regulates osteoblastic bone formation, via promotion of osteoblast differentiation (By similarity). Positively regulates osteoclast differentiation, potentially via NFATC1 signaling (By similarity). May play a role in skeletal muscle fiber type specification, potentially via NFATC1 signaling (By similarity). Negatively regulates MAP3K14/NIK signaling via inhibition of nuclear translocation of the transcription factors RELA and RELB (By similarity). Required for antigen-specific T-cell proliferation response (By similarity). Dephosphorylates KLHL3, promoting the interaction between KLHL3 and WNK4 and subsequent degradation of WNK4 (PubMed:30718414). Negatively regulates SLC9A1 activity (PubMed:31375679). {ECO:0000250|UniProtKB:P48452, ECO:0000250|UniProtKB:P63328, ECO:0000250|UniProtKB:P63329, ECO:0000269|PubMed:15671020, ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:17502104, ECO:0000269|PubMed:18838687, ECO:0000269|PubMed:19154138, ECO:0000269|PubMed:22343722, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:26248042, ECO:0000269|PubMed:27974827, ECO:0000269|PubMed:30254215, ECO:0000269|PubMed:30611118, ECO:0000269|PubMed:30718414, ECO:0000269|PubMed:31375679, ECO:0000269|PubMed:33691586}.
Q08357 SLC20A2 S375 ochoa Sodium-dependent phosphate transporter 2 (Gibbon ape leukemia virus receptor 2) (GLVR-2) (Phosphate transporter 2) (PiT-2) (Pit2) (hPit2) (Solute carrier family 20 member 2) Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:12205090, PubMed:15955065, PubMed:16790504, PubMed:17494632, PubMed:22327515, PubMed:28722801, PubMed:30704756). Plays a critical role in the determination of bone quality and strength by providing phosphate for bone mineralization (By similarity). Required to maintain normal cerebrospinal fluid phosphate levels (By similarity). Mediates phosphate-induced calcification of vascular smooth muscle cells (VCMCs) and can functionally compensate for loss of SLC20A1 in VCMCs (By similarity). {ECO:0000250|UniProtKB:Q80UP8, ECO:0000269|PubMed:12205090, ECO:0000269|PubMed:15955065, ECO:0000269|PubMed:16790504, ECO:0000269|PubMed:17494632, ECO:0000269|PubMed:22327515, ECO:0000269|PubMed:28722801, ECO:0000269|PubMed:30704756}.; FUNCTION: (Microbial infection) Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) variants. {ECO:0000269|PubMed:11435563, ECO:0000269|PubMed:12205090, ECO:0000269|PubMed:15955065, ECO:0000269|PubMed:8302848}.
Q09472 EP300 S19 psp Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-) Functions as a histone acetyltransferase and regulates transcription via chromatin remodeling (PubMed:23415232, PubMed:23934153, PubMed:8945521). Acetylates all four core histones in nucleosomes (PubMed:23415232, PubMed:23934153, PubMed:8945521). Histone acetylation gives an epigenetic tag for transcriptional activation (PubMed:23415232, PubMed:23934153, PubMed:8945521). Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (PubMed:23415232). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905, PubMed:23911289). Also able to acetylate histone lysine residues that are already monomethylated on the same side chain to form N6-acetyl-N6-methyllysine (Kacme), an epigenetic mark of active chromatin associated with increased transcriptional initiation (PubMed:37731000). Catalyzes formation of histone H4 acetyl-methylated at 'Lys-5' and 'Lys-12' (H4K5acme and H4K12acme, respectively) (PubMed:37731000). Also functions as acetyltransferase for non-histone targets, such as ALX1, HDAC1, PRMT1, SIRT2, STAT3 or GLUL (PubMed:12929931, PubMed:15653507, PubMed:16285960, PubMed:16762839, PubMed:18722353, PubMed:18782771, PubMed:26990986). Acetylates 'Lys-131' of ALX1 and acts as its coactivator (PubMed:12929931). Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of p53/TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function (PubMed:18722353). Following DNA damage, forms a stress-responsive p53/TP53 coactivator complex with JMY which mediates p53/TP53 acetylation, thereby increasing p53/TP53-dependent transcription and apoptosis (PubMed:11511361, PubMed:15448695). Promotes chromatin acetylation in heat shock responsive HSP genes during the heat shock response (HSR), thereby stimulating HSR transcription (PubMed:18451878). Acetylates HDAC1 leading to its inactivation and modulation of transcription (PubMed:16762839). Acetylates 'Lys-247' of EGR2 (By similarity). Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2 (PubMed:12586840). Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement (PubMed:14752053). Can also mediate transcriptional repression. Acetylates FOXO1 and enhances its transcriptional activity (PubMed:15890677). Acetylates STAT3 at different sites, promoting both STAT3 dimerization and activation and recruitment to chromatin (PubMed:15653507, PubMed:16285960, PubMed:18782771). Acetylates BCL6 which disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity (PubMed:12402037). Participates in CLOCK or NPAS2-regulated rhythmic gene transcription; exhibits a circadian association with CLOCK or NPAS2, correlating with increase in PER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter (PubMed:14645221). Acetylates MTA1 at 'Lys-626' which is essential for its transcriptional coactivator activity (PubMed:16617102). Acetylates XBP1 isoform 2; acetylation increases protein stability of XBP1 isoform 2 and enhances its transcriptional activity (PubMed:20955178). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates MEF2D (PubMed:21030595). Acetylates and stabilizes ZBTB7B protein by antagonizing ubiquitin conjugation and degradation, this mechanism may be involved in CD4/CD8 lineage differentiation (PubMed:20810990). Acetylates GABPB1, impairing GABPB1 heterotetramerization and activity (By similarity). Acetylates PCK1 and promotes PCK1 anaplerotic activity (PubMed:30193097). Acetylates RXRA and RXRG (PubMed:17761950). Acetylates isoform M2 of PKM (PKM2), promoting its homodimerization and conversion into a protein kinase (PubMed:24120661). Acetylates RPTOR in response to leucine, leading to activation of the mTORC1 complex (PubMed:30197302, PubMed:32561715). Acetylates RICTOR, leading to activation of the mTORC2 complex (PubMed:22084251). Mediates cAMP-gene regulation by binding specifically to phosphorylated CREBBP (PubMed:8917528). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA), butanoyl-CoA (butyryl-CoA), 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA), lactoyl-CoA or propanoyl-CoA (propionyl-CoA), and is able to mediate protein crotonylation, butyrylation, 2-hydroxyisobutyrylation, lactylation or propionylation, respectively (PubMed:17267393, PubMed:25818647, PubMed:29775581, PubMed:31645732). Acts as a histone crotonyltransferase; crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25818647). Histone crotonyltransferase activity is dependent on the concentration of (2E)-butenoyl-CoA (crotonyl-CoA) substrate and such activity is weak when (2E)-butenoyl-CoA (crotonyl-CoA) concentration is low (PubMed:25818647). Also acts as a histone butyryltransferase; butyrylation marks active promoters (PubMed:17267393). Catalyzes histone lactylation in macrophages by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription (PubMed:31645732). Acts as a protein-lysine 2-hydroxyisobutyryltransferase; regulates glycolysis by mediating 2-hydroxyisobutyrylation of glycolytic enzymes (PubMed:29775581). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000250|UniProtKB:B2RWS6, ECO:0000269|PubMed:10733570, ECO:0000269|PubMed:11430825, ECO:0000269|PubMed:11511361, ECO:0000269|PubMed:11701890, ECO:0000269|PubMed:12402037, ECO:0000269|PubMed:12586840, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:14752053, ECO:0000269|PubMed:15186775, ECO:0000269|PubMed:15448695, ECO:0000269|PubMed:15653507, ECO:0000269|PubMed:15890677, ECO:0000269|PubMed:16285960, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:16762839, ECO:0000269|PubMed:17267393, ECO:0000269|PubMed:17761950, ECO:0000269|PubMed:18451878, ECO:0000269|PubMed:18722353, ECO:0000269|PubMed:18782771, ECO:0000269|PubMed:18995842, ECO:0000269|PubMed:20810990, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:22084251, ECO:0000269|PubMed:23415232, ECO:0000269|PubMed:23911289, ECO:0000269|PubMed:23934153, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:25818647, ECO:0000269|PubMed:26990986, ECO:0000269|PubMed:29775581, ECO:0000269|PubMed:30193097, ECO:0000269|PubMed:30197302, ECO:0000269|PubMed:31645732, ECO:0000269|PubMed:32561715, ECO:0000269|PubMed:37731000, ECO:0000269|PubMed:8917528, ECO:0000269|PubMed:8945521, ECO:0000305|PubMed:20955178}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. {ECO:0000269|PubMed:10545121, ECO:0000269|PubMed:11080476}.
Q13330 MTA1 S558 ochoa Metastasis-associated protein MTA1 Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator (PubMed:16617102, PubMed:17671180, PubMed:17922032, PubMed:21965678, PubMed:24413532). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). In the NuRD complex, regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA (PubMed:17671180). In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A (PubMed:17922032, PubMed:24413532). Acts as a transcriptional coactivator of BCAS3, and SUMO2, independent of the NuRD complex (PubMed:16617102, PubMed:17671180, PubMed:21965678). Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3 (By similarity). Regulates p53-dependent and -independent DNA repair processes following genotoxic stress (PubMed:19837670). Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair (PubMed:19837670). Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles (By similarity). Positively regulates the CLOCK-BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1 (By similarity). Regulates deacetylation of BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression (By similarity). With TFCP2L1, promotes establishment and maintenance of pluripotency in embryonic stem cells (ESCs) and inhibits endoderm differentiation (By similarity). {ECO:0000250|UniProtKB:Q8K4B0, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:17671180, ECO:0000269|PubMed:17922032, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:24413532}.; FUNCTION: [Isoform Short]: Binds to ESR1 and sequesters it in the cytoplasm and enhances its non-genomic responses. {ECO:0000269|PubMed:15077195}.
Q13464 ROCK1 S1328 ochoa Rho-associated protein kinase 1 (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-35) (Rho-associated, coiled-coil-containing protein kinase 1) (Rho-associated, coiled-coil-containing protein kinase I) (ROCK-I) (p160 ROCK-1) (p160ROCK) Protein kinase which is a key regulator of the actin cytoskeleton and cell polarity (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:8617235, PubMed:9722579). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:23093407, PubMed:23355470, PubMed:8617235, PubMed:9722579). Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing (PubMed:18694941). Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (PubMed:19036714). Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability (By similarity). Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation (PubMed:19181962). Required for centrosome positioning and centrosome-dependent exit from mitosis (By similarity). Plays a role in terminal erythroid differentiation (PubMed:21072057). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Promotes keratinocyte terminal differentiation (PubMed:19997641). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles (By similarity). {ECO:0000250|UniProtKB:P70335, ECO:0000250|UniProtKB:Q8MIT6, ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:10652353, ECO:0000269|PubMed:11018042, ECO:0000269|PubMed:11283607, ECO:0000269|PubMed:17158456, ECO:0000269|PubMed:18573880, ECO:0000269|PubMed:18694941, ECO:0000269|PubMed:19036714, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19181962, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21072057, ECO:0000269|PubMed:23093407, ECO:0000269|PubMed:23355470, ECO:0000269|PubMed:8617235, ECO:0000269|PubMed:9722579}.
Q13625 TP53BP2 S481 ochoa Apoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2) Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53 (PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of NAE1 to conjugate NEDD8 to CUL1, and thereby decreases NAE1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. {ECO:0000269|PubMed:11684014, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:12694406, ECO:0000269|PubMed:19377511}.
Q14005 IL16 S795 ochoa Pro-interleukin-16 [Cleaved into: Interleukin-16 (IL-16) (Lymphocyte chemoattractant factor) (LCF)] Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.; FUNCTION: [Isoform 1]: May act as a scaffolding protein that anchors ion channels in the membrane.; FUNCTION: Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.
Q14202 ZMYM3 S790 ochoa Zinc finger MYM-type protein 3 (Zinc finger protein 261) Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}.
Q14686 NCOA6 S1240 ochoa Nuclear receptor coactivator 6 (Activating signal cointegrator 2) (ASC-2) (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Nuclear receptor-activating protein, 250 kDa) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Thyroid hormone receptor-binding protein) Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins.
Q15036 SNX17 S428 ochoa Sorting nexin-17 Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels (PubMed:15121882, PubMed:15769472, PubMed:39587083). Binds to NPxY sequences in the cytoplasmic tails of target cargos (PubMed:21512128). Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits (PubMed:22492727, PubMed:28892079, PubMed:39587083). Also required for maintenance of normal cell surface levels of APP and LRP1 (PubMed:16712798, PubMed:19005208). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (PubMed:16712798). {ECO:0000269|PubMed:15121882, ECO:0000269|PubMed:15769472, ECO:0000269|PubMed:16712798, ECO:0000269|PubMed:19005208, ECO:0000269|PubMed:21512128, ECO:0000269|PubMed:22492727, ECO:0000269|PubMed:28892079}.
Q15643 TRIP11 S1858 ochoa Thyroid receptor-interacting protein 11 (TR-interacting protein 11) (TRIP-11) (Clonal evolution-related gene on chromosome 14 protein) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) Is a membrane tether required for vesicle tethering to Golgi. Has an essential role in the maintenance of Golgi structure and function (PubMed:25473115, PubMed:30728324). It is required for efficient anterograde and retrograde trafficking in the early secretory pathway, functioning at both the ER-to-Golgi intermediate compartment (ERGIC) and Golgi complex (PubMed:25717001). Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription. {ECO:0000269|PubMed:10189370, ECO:0000269|PubMed:25473115, ECO:0000269|PubMed:25717001, ECO:0000269|PubMed:30728324, ECO:0000269|PubMed:9256431}.
Q15788 NCOA1 S22 ochoa|psp Nuclear receptor coactivator 1 (NCoA-1) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 74) (bHLHe74) (Protein Hin-2) (RIP160) (Renal carcinoma antigen NY-REN-52) (Steroid receptor coactivator 1) (SRC-1) Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3. {ECO:0000269|PubMed:10449719, ECO:0000269|PubMed:12954634, ECO:0000269|PubMed:7481822, ECO:0000269|PubMed:9223281, ECO:0000269|PubMed:9223431, ECO:0000269|PubMed:9296499, ECO:0000269|PubMed:9427757}.
Q15911 ZFHX3 S2795 ochoa Zinc finger homeobox protein 3 (AT motif-binding factor 1) (AT-binding transcription factor 1) (Alpha-fetoprotein enhancer-binding protein) (Zinc finger homeodomain protein 3) (ZFH-3) Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3 (PubMed:25105025). Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain (By similarity). Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression (PubMed:11312261). Down-regulates the MUC5AC promoter in gastric cancer (PubMed:17330845). In association with RUNX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). Inhibits estrogen receptor (ESR1) function by selectively competing with coactivator NCOA3 for binding to ESR1 in ESR1-positive breast cancer cells (PubMed:20720010). {ECO:0000250|UniProtKB:Q61329, ECO:0000269|PubMed:11312261, ECO:0000269|PubMed:17330845, ECO:0000269|PubMed:20599712, ECO:0000269|PubMed:20720010, ECO:0000269|PubMed:25105025}.
Q16584 MAP3K11 S548 ochoa|psp Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase) Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle. {ECO:0000269|PubMed:12529434, ECO:0000269|PubMed:15258589, ECO:0000269|PubMed:8195146, ECO:0000269|PubMed:9003778}.
Q16666 IFI16 S493 ochoa Gamma-interferon-inducible protein 16 (Ifi-16) (Interferon-inducible myeloid differentiation transcriptional activator) Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53 sequence-specific DNA binding and modulating TP53 phosphorylation status. Seems to be involved in energy-level-dependent activation of the ATM/ AMPK/TP53 pathway coupled to regulation of autophagy. May be involved in regulation of TP53-mediated cell death also involving BRCA1. May be involved in the senescence of prostate epithelial cells. Involved in innate immune response by recognizing viral dsDNA in the cytosol and probably in the nucleus. After binding to viral DNA in the cytoplasm recruits TMEM173/STING and mediates the induction of IFN-beta. Has anti-inflammatory activity and inhibits the activation of the AIM2 inflammasome, probably via association with AIM2. Proposed to bind viral DNA in the nucleus, such as of Kaposi's sarcoma-associated herpesvirus, and to induce the formation of nuclear caspase-1-activating inflammasome formation via association with PYCARD. Inhibits replication of herpesviruses such as human cytomegalovirus (HCMV) probably by interfering with promoter recruitment of members of the Sp1 family of transcription factors. Necessary to activate the IRF3 signaling cascade during human herpes simplex virus 1 (HHV-1) infection and promotes the assembly of heterochromatin on herpesviral DNA and inhibition of viral immediate-early gene expression and replication. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. {ECO:0000269|PubMed:11146555, ECO:0000269|PubMed:12894224, ECO:0000269|PubMed:14654789, ECO:0000269|PubMed:20890285, ECO:0000269|PubMed:21573174, ECO:0000269|PubMed:21575908, ECO:0000269|PubMed:22046441, ECO:0000269|PubMed:22291595, ECO:0000269|PubMed:23027953, ECO:0000269|PubMed:24198334, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:9642285}.; FUNCTION: [Isoform IFI16-beta]: Isoform that specifically inhibits the AIM2 inflammasome (PubMed:30104205). Binds double-stranded DNA (dsDNA) in the cytoplasm, impeding its detection by AIM2 (PubMed:30104205). Also prevents the interaction between AIM2 and PYCARD/ASC via its interaction with AIM2, thereby inhibiting assembly of the AIM2 inflammasome (PubMed:30104205). This isoform also weakly induce production of type I interferon-beta (IFNB1) via its interaction with STING1 (PubMed:30104205). {ECO:0000269|PubMed:30104205}.
Q16825 PTPN21 S590 ochoa Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1) None
Q2M1Z3 ARHGAP31 S1036 ochoa Rho GTPase-activating protein 31 (Cdc42 GTPase-activating protein) Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading, polarized lamellipodia formation and cell migration. {ECO:0000269|PubMed:12192056, ECO:0000269|PubMed:16519628}.
Q32P44 EML3 S207 ochoa Echinoderm microtubule-associated protein-like 3 (EMAP-3) Regulates mitotic spindle assembly, microtubule (MT)-kinetochore attachment and chromosome separation via recruitment of HAUS augmin-like complex and TUBG1 to the existing MTs and promoting MT-based MT nucleation (PubMed:30723163). Required for proper alignnment of chromosomes during metaphase (PubMed:18445686). {ECO:0000269|PubMed:18445686, ECO:0000269|PubMed:30723163}.
Q53EP0 FNDC3B S393 ochoa Fibronectin type III domain-containing protein 3B (Factor for adipocyte differentiation 104) (HCV NS5A-binding protein 37) May be a positive regulator of adipogenesis. {ECO:0000269|PubMed:15564382}.
Q53H80 AKIRIN2 S134 ochoa Akirin-2 Molecular adapter that acts as a bridge between a variety of multiprotein complexes, and which is involved in embryonic development, immunity, myogenesis and brain development (PubMed:34711951). Plays a key role in nuclear protein degradation by promoting import of proteasomes into the nucleus: directly binds to fully assembled 20S proteasomes at one end and to nuclear import receptor IPO9 at the other end, bridging them together and mediating the import of pre-assembled proteasome complexes through the nuclear pore (PubMed:34711951). Involved in innate immunity by regulating the production of interleukin-6 (IL6) downstream of Toll-like receptor (TLR): acts by bridging the NF-kappa-B inhibitor NFKBIZ and the SWI/SNF complex, leading to promote induction of IL6 (By similarity). Also involved in adaptive immunity by promoting B-cell activation (By similarity). Involved in brain development: required for the survival and proliferation of cerebral cortical progenitor cells (By similarity). Involved in myogenesis: required for skeletal muscle formation and skeletal development, possibly by regulating expression of muscle differentiation factors (By similarity). Also plays a role in facilitating interdigital tissue regression during limb development (By similarity). {ECO:0000250|UniProtKB:B1AXD8, ECO:0000269|PubMed:34711951}.
Q5FWF5 ESCO1 S288 ochoa N-acetyltransferase ESCO1 (EC 2.3.1.-) (CTF7 homolog 1) (Establishment factor-like protein 1) (EFO1) (EFO1p) (hEFO1) (Establishment of cohesion 1 homolog 1) (ECO1 homolog 1) (ESO1 homolog 1) Acetyltransferase required for the establishment of sister chromatid cohesion (PubMed:15958495, PubMed:18614053). Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by mediating the acetylation of cohesin component SMC3 (PubMed:18614053). {ECO:0000269|PubMed:14576321, ECO:0000269|PubMed:15958495, ECO:0000269|PubMed:18614053, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:27112597, ECO:0000269|PubMed:27803161}.
Q5R372 RABGAP1L S128 ochoa Rab GTPase-activating protein 1-like GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (PubMed:16923123). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:A6H6A9, ECO:0000269|PubMed:16923123}.
Q5SW79 CEP170 S939 ochoa Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}.
Q5SW79 CEP170 S1145 ochoa Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}.
Q5T5Y3 CAMSAP1 S371 ochoa Calmodulin-regulated spectrin-associated protein 1 Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19508979, PubMed:21834987, PubMed:24117850, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and stabilizes microtubules (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation (PubMed:24486153, PubMed:24706919). Through interaction with spectrin may regulate neurite outgrowth (PubMed:24117850). {ECO:0000269|PubMed:19508979, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:24117850, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919}.
Q5VT06 CEP350 S1265 ochoa Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CPAP (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}.
Q69YH5 CDCA2 S608 ochoa Cell division cycle-associated protein 2 (Recruits PP1 onto mitotic chromatin at anaphase protein) (Repo-Man) Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. {ECO:0000269|PubMed:16492807, ECO:0000269|PubMed:16998479}.
Q6NTF9 RHBDD2 S276 ochoa Rhomboid domain-containing protein 2 None
Q6NZY4 ZCCHC8 S331 ochoa Zinc finger CCHC domain-containing protein 8 (TRAMP-like complex RNA-binding factor ZCCHC8) Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex that is involved in the surveillance and turnover of aberrant transcripts and non-coding RNAs (PubMed:27871484). NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. May be involved in pre-mRNA splicing (Probable). It is required for 3'-end maturation of telomerase RNA component (TERC), TERC 3'-end targeting to the nuclear RNA exosome, and for telomerase function (PubMed:31488579). {ECO:0000269|PubMed:27871484, ECO:0000269|PubMed:31488579, ECO:0000305|PubMed:16263084}.
Q6P2E9 EDC4 S705 ochoa Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls) In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). {ECO:0000269|PubMed:16364915}.
Q6P4E1 GOLM2 S328 ochoa Protein GOLM2 (Cancer susceptibility candidate gene 4 protein) (CASC4) (Golgi membrane protein 2) None
Q6PL18 ATAD2 S1170 ochoa ATPase family AAA domain-containing protein 2 (EC 3.6.1.-) (AAA nuclear coregulator cancer-associated protein) (ANCCA) May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells. {ECO:0000269|PubMed:17998543}.
Q702N8 XIRP1 S418 ochoa Xin actin-binding repeat-containing protein 1 (Cardiomyopathy-associated protein 1) Protects actin filaments from depolymerization (PubMed:15454575). Required for correct cardiac intercalated disk ultrastructure via maintenance of cell-cell adhesion stability, and as a result maintains cardiac organ morphology, conductance and heart beat rhythm (By similarity). Required for development of normal skeletal muscle morphology and muscle fiber type composition (By similarity). Plays a role in regulating muscle satellite cell activation and survival, as a result promotes muscle fiber recovery from injury and fatigue (By similarity). {ECO:0000250|UniProtKB:O70373, ECO:0000269|PubMed:15454575}.
Q7L1V2 MON1B S71 ochoa Vacuolar fusion protein MON1 homolog B (HSV-1 stimulation-related gene 1 protein) (HSV-I stimulating-related protein) None
Q7L2H7 EIF3M S152 ochoa Eukaryotic translation initiation factor 3 subunit M (eIF3m) (Fetal lung protein B5) (hFL-B5) (PCI domain-containing protein 1) Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17403899, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17403899). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03012, ECO:0000269|PubMed:17403899, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) May favor virus entry in case of infection with herpes simplex virus 1 (HSV1) or herpes simplex virus 2 (HSV2). {ECO:0000269|PubMed:15919898}.
Q7Z2W4 ZC3HAV1 S387 ochoa Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP) Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). {ECO:0000269|PubMed:18225958, ECO:0000269|PubMed:21102435, ECO:0000269|PubMed:21876179, ECO:0000269|PubMed:22720057}.
Q7Z2Z1 TICRR S1840 ochoa Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}.
Q7Z6G8 ANKS1B S1223 ochoa Ankyrin repeat and sterile alpha motif domain-containing protein 1B (Amyloid-beta protein intracellular domain-associated protein 1) (AIDA-1) (E2A-PBX1-associated protein) (EB-1) Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells.; FUNCTION: Isoform 3 can regulate global protein synthesis by altering nucleolar numbers. {ECO:0000250, ECO:0000269|PubMed:15347684, ECO:0000269|PubMed:15862129}.; FUNCTION: Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing.
Q86UU1 PHLDB1 S290 ochoa Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha) None
Q86V48 LUZP1 S531 ochoa Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin) F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250|UniProtKB:Q8R4U7, ECO:0000269|PubMed:30990684, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:38009294, ECO:0000269|PubMed:38832964}.
Q86XL3 ANKLE2 S277 ochoa Ankyrin repeat and LEM domain-containing protein 2 (LEM domain-containing protein 4) Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit (PubMed:22770216). Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly (PubMed:22770216). May regulate nuclear localization of VRK1 in non-dividing cells (PubMed:31735666). It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex (PubMed:22770216). Involved in brain development (PubMed:25259927). {ECO:0000269|PubMed:22770216, ECO:0000269|PubMed:25259927, ECO:0000269|PubMed:31735666}.
Q8IWZ3 ANKHD1 S740 ochoa Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases. {ECO:0000269|PubMed:16098192}.
Q8IX01 SUGP2 S572 ochoa SURP and G-patch domain-containing protein 2 (Arginine/serine-rich-splicing factor 14) (Splicing factor, arginine/serine-rich 14) May play a role in mRNA splicing. {ECO:0000305}.
Q8IY92 SLX4 S1087 ochoa Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. {ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19595722, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}.
Q8IYP9 ZDHHC23 S206 ochoa Palmitoyltransferase ZDHHC23 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 23) (DHHC-23) (zDHHC23) Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates and be involved in a variety of cellular processes (Probable). Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane. May be involved in NOS1 regulation and targeting to the synaptic membrane. {ECO:0000269|PubMed:22399288, ECO:0000305|PubMed:22399288}.
Q8N5K1 CISD2 S69 ochoa CDGSH iron-sulfur domain-containing protein 2 (Endoplasmic reticulum intermembrane small protein) (MitoNEET-related 1 protein) (Miner1) (Nutrient-deprivation autophagy factor-1) (NAF-1) Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy. {ECO:0000269|PubMed:17846994, ECO:0000269|PubMed:20010695}.
Q8ND30 PPFIBP2 S454 ochoa Liprin-beta-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2) (PTPRF-interacting protein-binding protein 2) May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A. {ECO:0000269|PubMed:9624153}.
Q8NEN9 PDZD8 S530 ochoa PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR-104) Molecular tethering protein that connects endoplasmic reticulum and mitochondria membranes (PubMed:29097544). PDZD8-dependent endoplasmic reticulum-mitochondria membrane tethering is essential for endoplasmic reticulum-mitochondria Ca(2+) transfer (PubMed:29097544). In neurons, involved in the regulation of dendritic Ca(2+) dynamics by regulating mitochondrial Ca(2+) uptake in neurons (PubMed:29097544). Plays an indirect role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987). May inhibit herpes simplex virus 1 infection at an early stage (PubMed:21549406). {ECO:0000269|PubMed:21549406, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:29097544}.
Q8TC05 MDM1 S560 ochoa Nuclear protein MDM1 Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules (PubMed:26337392). {ECO:0000269|PubMed:26337392}.
Q8TF72 SHROOM3 S1490 ochoa Protein Shroom3 (Shroom-related protein) (hShrmL) Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}.
Q92539 LPIN2 S303 ochoa Phosphatidate phosphatase LPIN2 (EC 3.1.3.4) (Lipin-2) Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the endoplasmic reticulum membrane. Plays important roles in controlling the metabolism of fatty acids at different levels. Also acts as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism. {ECO:0000250|UniProtKB:Q99PI5}.
Q92547 TOPBP1 S860 ochoa DNA topoisomerase 2-binding protein 1 (DNA topoisomerase II-beta-binding protein 1) (TopBP1) (DNA topoisomerase II-binding protein 1) Scaffold protein that acts as a key protein-protein adapter in DNA replication and DNA repair (PubMed:10498869, PubMed:11395493, PubMed:11714696, PubMed:17575048, PubMed:20545769, PubMed:21777809, PubMed:26811421, PubMed:30898438, PubMed:31135337, PubMed:33592542, PubMed:35597237, PubMed:37674080). Composed of multiple BRCT domains, which specifically recognize and bind phosphorylated proteins, bringing proteins together into functional combinations (PubMed:17575048, PubMed:20545769, PubMed:21777809, PubMed:26811421, PubMed:30898438, PubMed:31135337, PubMed:35597237, PubMed:37674080). Required for DNA replication initiation but not for the formation of pre-replicative complexes or the elongation stages (By similarity). Necessary for the loading of replication factors onto chromatin, including GMNC, CDC45, DNA polymerases and components of the GINS complex (By similarity). Plays a central role in DNA repair by bridging proteins and promoting recruitment of proteins to DNA damage sites (PubMed:30898438, PubMed:35597237, PubMed:37674080). Involved in double-strand break (DSB) repair via homologous recombination in S-phase by promoting the exchange between the DNA replication factor A (RPA) complex and RAD51 (PubMed:26811421, PubMed:35597237). Mechanistically, TOPBP1 is recruited to DNA damage sites in S-phase via interaction with phosphorylated HTATSF1, and promotes the loading of RAD51, thereby facilitating RAD51 nucleofilaments formation and RPA displacement, followed by homologous recombination (PubMed:35597237). Involved in microhomology-mediated end-joining (MMEJ) DNA repair by promoting recruitment of polymerase theta (POLQ) to DNA damage sites during mitosis (PubMed:37674080). MMEJ is an alternative non-homologous end-joining (NHEJ) machinery that takes place during mitosis to repair DSBs in DNA that originate in S-phase (PubMed:37674080). Recognizes and binds POLQ phosphorylated by PLK1, enabling its recruitment to DSBs for subsequent repair (PubMed:37674080). Involved in G1 DNA damage checkpoint by acting as a molecular adapter that couples TP53BP1 and the 9-1-1 complex (PubMed:31135337). In response to DNA damage, triggers the recruitment of checkpoint signaling proteins on chromatin, which activate the CHEK1 signaling pathway and block S-phase progression (PubMed:16530042, PubMed:21777809). Acts as an activator of the kinase activity of ATR (PubMed:16530042, PubMed:21777809). Also required for chromosomal stability when DSBs occur during mitosis by forming filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Together with CIP2A, plays an essential role in the response to genome instability generated by the presence of acentric chromosome fragments derived from shattered chromosomes within micronuclei (PubMed:35121901, PubMed:35842428, PubMed:37165191, PubMed:37316668). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, the CIP2A-TOPBP1 complex tethers chromosome fragments during mitosis to ensure clustered segregation of the fragments to a single daughter cell nucleus, facilitating re-ligation with limited chromosome scattering and loss (PubMed:37165191, PubMed:37316668). Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters, thereby down-regulating E2F1 activity and inhibiting E2F1-dependent apoptosis during G1/S transition and after DNA damage (PubMed:12697828, PubMed:15075294). {ECO:0000250|UniProtKB:Q800K6, ECO:0000269|PubMed:10498869, ECO:0000269|PubMed:11395493, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:12697828, ECO:0000269|PubMed:15075294, ECO:0000269|PubMed:16530042, ECO:0000269|PubMed:17575048, ECO:0000269|PubMed:20545769, ECO:0000269|PubMed:21777809, ECO:0000269|PubMed:26811421, ECO:0000269|PubMed:30898438, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:33592542, ECO:0000269|PubMed:35121901, ECO:0000269|PubMed:35597237, ECO:0000269|PubMed:35842428, ECO:0000269|PubMed:37165191, ECO:0000269|PubMed:37316668, ECO:0000269|PubMed:37674080}.
Q92585 MAML1 S168 ochoa Mastermind-like protein 1 (Mam-1) Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. {ECO:0000269|PubMed:11101851, ECO:0000269|PubMed:11390662, ECO:0000269|PubMed:12050117, ECO:0000269|PubMed:15546612, ECO:0000269|PubMed:17317671}.
Q92615 LARP4B S620 ochoa La-related protein 4B (La ribonucleoprotein domain family member 4B) (La ribonucleoprotein domain family member 5) (La-related protein 5) Stimulates mRNA translation. {ECO:0000269|PubMed:20573744}.
Q92870 APBB2 S44 ochoa Amyloid beta precursor protein binding family B member 2 (Amyloid-beta (A4) precursor protein-binding family B member 2) (Protein Fe65-like 1) Plays a role in the maintenance of lens transparency, and may also play a role in muscle cell strength (By similarity). Involved in hippocampal neurite branching and neuromuscular junction formation, as a result plays a role in spatial memory functioning (By similarity). Activates transcription of APP (PubMed:14527950). {ECO:0000250|UniProtKB:Q9DBR4, ECO:0000269|PubMed:14527950}.
Q96B36 AKT1S1 S221 psp Proline-rich AKT1 substrate 1 (40 kDa proline-rich AKT substrate) Negative regulator of the mechanistic target of rapamycin complex 1 (mTORC1), an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:17277771, PubMed:17386266, PubMed:17510057, PubMed:29236692). In absence of insulin and nutrients, AKT1S1 associates with the mTORC1 complex and directly inhibits mTORC1 activity by blocking the MTOR substrate-recruitment site (PubMed:29236692). In response to insulin and nutrients, AKT1S1 dissociates from mTORC1 (PubMed:17386266, PubMed:18372248). Its activity is dependent on its phosphorylation state and binding to 14-3-3 (PubMed:16174443, PubMed:18372248). May also play a role in nerve growth factor-mediated neuroprotection (By similarity). {ECO:0000250|UniProtKB:Q9D1F4, ECO:0000269|PubMed:16174443, ECO:0000269|PubMed:17277771, ECO:0000269|PubMed:17386266, ECO:0000269|PubMed:17510057, ECO:0000269|PubMed:18372248, ECO:0000269|PubMed:29236692}.
Q96F45 ZNF503 S111 ochoa Zinc finger protein 503 May function as a transcriptional repressor. {ECO:0000250}.
Q96F63 CCDC97 S221 ochoa Coiled-coil domain-containing protein 97 May play a role pre-mRNA splicing through the association with the splicing factor SF3B complex which is involved in branch-site recognition. {ECO:0000269|PubMed:26344197}.
Q96J02 ITCH S450 psp E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1) Acts as an Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:11046148, PubMed:14602072, PubMed:15051726, PubMed:16387660, PubMed:17028573, PubMed:18718448, PubMed:18718449, PubMed:19116316, PubMed:19592251, PubMed:19881509, PubMed:20068034, PubMed:20392206, PubMed:20491914, PubMed:23146885, PubMed:24790097, PubMed:25631046). Catalyzes 'Lys-29'-, 'Lys-48'- and 'Lys-63'-linked ubiquitin conjugation (PubMed:17028573, PubMed:18718448, PubMed:19131965, PubMed:19881509). Involved in the control of inflammatory signaling pathways (PubMed:19131965). Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, TAX1BP1 and RNF11, that ensures the transient nature of inflammatory signaling pathways (PubMed:19131965). Promotes the association of the complex after TNF stimulation (PubMed:19131965). Once the complex is formed, TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains (PubMed:19131965). This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NFKB1 (PubMed:19131965). Ubiquitinates RIPK2 by 'Lys-63'-linked conjugation and influences NOD2-dependent signal transduction pathways (PubMed:19592251). Regulates the transcriptional activity of several transcription factors, and probably plays an important role in the regulation of immune response (PubMed:18718448, PubMed:20491914). Ubiquitinates NFE2 by 'Lys-63' linkages and is implicated in the control of the development of hematopoietic lineages (PubMed:18718448). Mediates JUN ubiquitination and degradation (By similarity). Mediates JUNB ubiquitination and degradation (PubMed:16387660). Critical regulator of type 2 helper T (Th2) cell cytokine production by inducing JUNB ubiquitination and degradation (By similarity). Involved in the negative regulation of MAVS-dependent cellular antiviral responses (PubMed:19881509). Ubiquitinates MAVS through 'Lys-48'-linked conjugation resulting in MAVS proteasomal degradation (PubMed:19881509). Following ligand stimulation, regulates sorting of Wnt receptor FZD4 to the degradative endocytic pathway probably by modulating PI42KA activity (PubMed:23146885). Ubiquitinates PI4K2A and negatively regulates its catalytic activity (PubMed:23146885). Ubiquitinates chemokine receptor CXCR4 and regulates sorting of CXCR4 to the degradative endocytic pathway following ligand stimulation by ubiquitinating endosomal sorting complex required for transport ESCRT-0 components HGS and STAM (PubMed:14602072, PubMed:23146885, PubMed:34927784). Targets DTX1 for lysosomal degradation and controls NOTCH1 degradation, in the absence of ligand, through 'Lys-29'-linked polyubiquitination (PubMed:17028573, PubMed:18628966, PubMed:23886940). Ubiquitinates SNX9 (PubMed:20491914). Ubiquitinates MAP3K7 through 'Lys-48'-linked conjugation (By similarity). Together with UBR5, involved in the regulation of apoptosis and reactive oxygen species levels through the ubiquitination and proteasomal degradation of TXNIP: catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP (PubMed:20068034, PubMed:29378950). ITCH synthesizes 'Lys-63'-linked chains, while UBR5 is branching multiple 'Lys-48'-linked chains of substrate initially modified (PubMed:29378950). Mediates the antiapoptotic activity of epidermal growth factor through the ubiquitination and proteasomal degradation of p15 BID (PubMed:20392206). Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Inhibits the replication of influenza A virus (IAV) via ubiquitination of IAV matrix protein 1 (M1) through 'Lys-48'-linked conjugation resulting in M1 proteasomal degradation (PubMed:30328013). Ubiquitinates NEDD9/HEF1, resulting in proteasomal degradation of NEDD9/HEF1 (PubMed:15051726). {ECO:0000250|UniProtKB:Q8C863, ECO:0000269|PubMed:14602072, ECO:0000269|PubMed:15051726, ECO:0000269|PubMed:16387660, ECO:0000269|PubMed:17028573, ECO:0000269|PubMed:18628966, ECO:0000269|PubMed:18718448, ECO:0000269|PubMed:18718449, ECO:0000269|PubMed:19116316, ECO:0000269|PubMed:19131965, ECO:0000269|PubMed:19592251, ECO:0000269|PubMed:19881509, ECO:0000269|PubMed:20068034, ECO:0000269|PubMed:20392206, ECO:0000269|PubMed:20491914, ECO:0000269|PubMed:23146885, ECO:0000269|PubMed:23886940, ECO:0000269|PubMed:24790097, ECO:0000269|PubMed:25631046, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:30328013}.
Q96QT4 TRPM7 S1513 ochoa|psp Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form] Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644). {ECO:0000250|UniProtKB:Q923J1, ECO:0000269|PubMed:11385574, ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:18365021, ECO:0000269|PubMed:18394644, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:35561741, ECO:0000269|PubMed:36027648}.; FUNCTION: [TRPM7 channel, cleaved form]: The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling. {ECO:0000250|UniProtKB:Q923J1}.; FUNCTION: [TRPM7 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development. {ECO:0000250|UniProtKB:Q923J1}.
Q96QZ7 MAGI1 S621 ochoa Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (Atrophin-1-interacting protein 3) (AIP-3) (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Trinucleotide repeat-containing gene 19 protein) (WW domain-containing protein 3) (WWP3) Plays a role in coupling actin fibers to cell junctions in endothelial cells, via its interaction with AMOTL2 and CDH5 (By similarity). May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q6RHR9}.
Q96R06 SPAG5 S217 ochoa Sperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126) Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase (PubMed:11724960, PubMed:12356910, PubMed:27462074). Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:17664331, PubMed:27462074). In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes (PubMed:18361916, PubMed:21402792). Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis (PubMed:23953116). May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU (PubMed:18055457). {ECO:0000269|PubMed:12356910, ECO:0000269|PubMed:17664331, ECO:0000269|PubMed:18055457, ECO:0000269|PubMed:18361916, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:23953116, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:27462074, ECO:0000305|PubMed:11724960}.
Q96R06 SPAG5 S401 ochoa Sperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126) Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase (PubMed:11724960, PubMed:12356910, PubMed:27462074). Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:17664331, PubMed:27462074). In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes (PubMed:18361916, PubMed:21402792). Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis (PubMed:23953116). May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU (PubMed:18055457). {ECO:0000269|PubMed:12356910, ECO:0000269|PubMed:17664331, ECO:0000269|PubMed:18055457, ECO:0000269|PubMed:18361916, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:23953116, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:27462074, ECO:0000305|PubMed:11724960}.
Q96RS0 TGS1 S307 ochoa Trimethylguanosine synthase (EC 2.1.1.-) (CLL-associated antigen KW-2) (Cap-specific guanine-N(2) methyltransferase) (Hepatocellular carcinoma-associated antigen 137) (Nuclear receptor coactivator 6-interacting protein) (PRIP-interacting protein with methyltransferase motif) (PIMT) (PIPMT) Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation. {ECO:0000269|PubMed:11517327, ECO:0000269|PubMed:11912212, ECO:0000269|PubMed:16687569, ECO:0000269|PubMed:18775984}.
Q96RT7 TUBGCP6 S1304 ochoa Gamma-tubulin complex component 6 (GCP-6) Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:11694571, PubMed:38305685, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685, PubMed:38609661, PubMed:39321809). {ECO:0000269|PubMed:11694571, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}.
Q99447 PCYT2 S336 ochoa Ethanolamine-phosphate cytidylyltransferase (EC 2.7.7.14) (CTP:phosphoethanolamine cytidylyltransferase) (Phosphorylethanolamine transferase) Ethanolamine-phosphate cytidylyltransferase that catalyzes the second step in the synthesis of phosphatidylethanolamine (PE) from ethanolamine via the CDP-ethanolamine pathway (PubMed:31637422, PubMed:9083101). Phosphatidylethanolamine is a dominant inner-leaflet phospholipid in cell membranes, where it plays a role in membrane function by structurally stabilizing membrane-anchored proteins, and participates in important cellular processes such as cell division, cell fusion, blood coagulation, and apoptosis (PubMed:9083101). {ECO:0000269|PubMed:31637422, ECO:0000269|PubMed:9083101, ECO:0000303|PubMed:9083101}.
Q99569 PKP4 S388 ochoa Plakophilin-4 (p0071) Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269|PubMed:17115030}.
Q99704 DOK1 S291 ochoa Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62) DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3. {ECO:0000269|PubMed:18156175}.
Q9BRR9 ARHGAP9 S144 ochoa Rho GTPase-activating protein 9 (Rho-type GTPase-activating protein 9) GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has a substantial GAP activity toward CDC42 and RAC1 and less toward RHOA. Has a role in regulating adhesion of hematopoietic cells to the extracellular matrix. Binds phosphoinositides, and has the highest affinity for phosphatidylinositol 3,4,5-trisphosphate, followed by phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate. {ECO:0000269|PubMed:11396949}.
Q9BUH8 BEGAIN S229 ochoa Brain-enriched guanylate kinase-associated protein May sustain the structure of the postsynaptic density (PSD).
Q9H2G9 BLZF1 S362 ochoa Golgin-45 (Basic leucine zipper nuclear factor 1) (JEM-1) (p45 basic leucine-zipper nuclear factor) Required for normal Golgi structure and for protein transport from the endoplasmic reticulum (ER) through the Golgi apparatus to the cell surface. {ECO:0000269|PubMed:11739401}.
Q9H4Z2 ZNF335 S1016 ochoa Zinc finger protein 335 (NRC-interacting factor 1) (NIF-1) Component or associated component of some histone methyltransferase complexes may regulate transcription through recruitment of those complexes on gene promoters (PubMed:19131338, PubMed:23178126). Enhances ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:12215545, PubMed:18180299, PubMed:19131338). Plays an important role in neural progenitor cell proliferation and self-renewal through the regulation of specific genes involved brain development, including REST (PubMed:23178126). Also controls the expression of genes involved in somatic development and regulates, for instance, lymphoblast proliferation (PubMed:23178126). {ECO:0000269|PubMed:12215545, ECO:0000269|PubMed:18180299, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:23178126}.
Q9H6U6 BCAS3 S706 ochoa BCAS3 microtubule associated cell migration factor (Breast carcinoma-amplified sequence 3) (GAOB1) Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation (By similarity). Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin. Plays a regulatory role in autophagic activity. In complex with PHAF1, associates with the preautophagosomal structure during both non-selective and selective autophagy (PubMed:33499712). Probably binds phosphatidylinositol 3-phosphate (PtdIns3P) which would mediate the recruitment preautophagosomal structures (PubMed:33499712). {ECO:0000250|UniProtKB:Q8CCN5, ECO:0000269|PubMed:17505058, ECO:0000269|PubMed:33499712}.
Q9H7S9 ZNF703 S87 ochoa Zinc finger protein 703 (Zinc finger elbow-related proline domain protein 1) Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be required for segmental gene expression during hindbrain development. {ECO:0000269|PubMed:21328542, ECO:0000269|PubMed:21337521}.
Q9H8Y8 GORASP2 S214 ochoa Golgi reassembly-stacking protein 2 (GRS2) (Golgi phosphoprotein 6) (GOLPH6) (Golgi reassembly-stacking protein of 55 kDa) (GRASP55) (p59) Key structural protein of the Golgi apparatus (PubMed:33301566). The membrane cisternae of the Golgi apparatus adhere to each other to form stacks, which are aligned side by side to form the Golgi ribbon (PubMed:33301566). Acting in concert with GORASP1/GRASP65, is required for the formation and maintenance of the Golgi ribbon, and may be dispensable for the formation of stacks (PubMed:33301566). However, other studies suggest that GORASP2 plays a role in the assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after breakdown during mitosis and meiosis (PubMed:10487747, PubMed:21515684, PubMed:22523075). May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane TGFA (PubMed:11101516). Required for normal acrosome formation during spermiogenesis and normal male fertility, probably by promoting colocalization of JAM2 and JAM3 at contact sites between germ cells and Sertoli cells (By similarity). Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (PubMed:21884936, PubMed:27062250, PubMed:28067262). {ECO:0000250|UniProtKB:Q99JX3, ECO:0000269|PubMed:10487747, ECO:0000269|PubMed:11101516, ECO:0000269|PubMed:21515684, ECO:0000269|PubMed:21884936, ECO:0000269|PubMed:22523075, ECO:0000269|PubMed:27062250, ECO:0000269|PubMed:28067262}.
Q9HBD1 RC3H2 S562 ochoa Roquin-2 (EC 2.3.2.27) (Membrane-associated nucleic acid-binding protein) (RING finger and CCCH-type zinc finger domain-containing protein 2) (RING finger protein 164) (RING-type E3 ubiquitin transferase Roquin-2) Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression. Also recognizes CDE in its own mRNA and in that of paralogous RC3H1, possibly leading to feedback loop regulation (By similarity). miRNA-binding protein that regulates microRNA homeostasis. Enhances DICER-mediated processing of pre-MIR146a but reduces mature MIR146a levels through an increase of 3' end uridylation. Both inhibits ICOS mRNA expression and they may act together to exert the suppression (PubMed:25697406). Acts as a ubiquitin E3 ligase. Pairs with E2 enzymes UBE2B, UBE2D2, UBE2E2, UBE2E3, UBE2G2, UBE2K and UBE2Q2 and produces polyubiquitin chains (PubMed:26489670). Shows the strongest activity when paired with UBE2N:UBE2V1 or UBE2N:UBE2V2 E2 complexes and generate both short and long polyubiquitin chains (PubMed:26489670). Involved in the ubiquitination of MAP3K5 (PubMed:24448648, PubMed:26489670, PubMed:29186683). Able to interact with double-stranded RNA (dsRNA) (PubMed:26489670). {ECO:0000250|UniProtKB:P0C090, ECO:0000269|PubMed:24448648, ECO:0000269|PubMed:26489670, ECO:0000269|PubMed:29186683}.
Q9NPA3 MID1IP1 S79 ochoa Mid1-interacting protein 1 (Gastrulation-specific G12-like protein) (Mid1-interacting G12-like protein) (Protein STRAIT11499) (Spot 14-related protein) (S14R) (Spot 14-R) Plays a role in the regulation of lipogenesis in liver. Up-regulates ACACA enzyme activity. Required for efficient lipid biosynthesis, including triacylglycerol, diacylglycerol and phospholipid. Involved in stabilization of microtubules (By similarity). {ECO:0000250}.
Q9NQS7 INCENP S223 ochoa Inner centromere protein Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:12925766, PubMed:15316025, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428). {ECO:0000250|UniProtKB:P53352, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:21346195, ECO:0000269|PubMed:27332895}.
Q9NQU5 PAK6 S360 psp Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (PAK-5) (p21-activated kinase 6) (PAK-6) Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Also inhibits ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD. {ECO:0000269|PubMed:14573606, ECO:0000269|PubMed:20054820}.
Q9NQV6 PRDM10 S820 ochoa PR domain zinc finger protein 10 (PR domain-containing protein 10) (Tristanin) Transcriptional activator, essential for early embryonic development and survival of embryonic stem cells (ESCs) (By similarity). Supports cell growth and survival during early development by transcriptionally activating the expression of the translation initiation factor EIF3B, to sustain global translation (By similarity). Activates the transcription of FLNC (PubMed:36440963). {ECO:0000250|UniProtKB:Q3UTQ7, ECO:0000269|PubMed:36440963}.
Q9NR82 KCNQ5 S831 ochoa Potassium voltage-gated channel subfamily KQT member 5 (KQT-like 5) (Potassium channel subunit alpha KvLQT5) (Voltage-gated potassium channel subunit Kv7.5) Pore-forming subunit of the voltage-gated potassium (Kv) channel broadly expressed in brain and involved in the regulation of neuronal excitability (PubMed:10787416, PubMed:10816588, PubMed:11159685, PubMed:28669405). Associates with KCNQ3/Kv7.3 pore-forming subunit to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons (PubMed:10816588, PubMed:11159685). Contributes, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current (PubMed:10816588). Also forms a functional channel with KCNQ1/Kv7.1 subunit that may contribute to vasoconstriction and hypertension (PubMed:24855057). Channel may be selectively permeable in vitro to other cations besides potassium, in decreasing order of affinity K(+) = Rb(+) > Cs(+) > Na(+) (PubMed:10816588). Similar to the native M-channel, KCNQ3-KCNQ5 potassium channel is suppressed by activation of the muscarinic acetylcholine receptor CHRM1 (PubMed:10816588). {ECO:0000269|PubMed:10787416, ECO:0000269|PubMed:10816588, ECO:0000269|PubMed:11159685, ECO:0000269|PubMed:24855057, ECO:0000269|PubMed:28669405}.
Q9NVD7 PARVA S28 ochoa Alpha-parvin (Actopaxin) (CH-ILKBP) (Calponin-like integrin-linked kinase-binding protein) (Matrix-remodeling-associated protein 2) Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishment of cell polarity, cell adhesion, cell spreading, and directed cell migration. Within the IPP (ILK-PINCH-PARVIN) complex, binds to F-actin, promoting F-actin bundling, a process required to generate force for actin cytoskeleton reorganization and subsequent dynamic cell adhesion events such as cell spreading and migration (PubMed:30367047). {ECO:0000250, ECO:0000269|PubMed:11134073, ECO:0000269|PubMed:11331308, ECO:0000269|PubMed:15284246, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:30367047}.
Q9P0L2 MARK1 S403 ochoa Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (EC 2.7.11.26) (MAP/microtubule affinity-regulating kinase 1) (PAR1 homolog c) (Par-1c) (Par1c) Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:17573348, ECO:0000269|PubMed:23666762}.
Q9P0U4 CXXC1 S19 ochoa CXXC-type zinc finger protein 1 (CpG-binding protein) (PHD finger and CXXC domain-containing protein 1) Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG. {ECO:0000269|PubMed:21407193}.
Q9P219 CCDC88C S1547 ochoa Protein Daple (Coiled-coil domain-containing protein 88C) (Dvl-associating protein with a high frequency of leucine residues) (hDaple) (Hook-related protein 2) (HkRP2) Required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling (PubMed:26126266). Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signaling (PubMed:26126266). Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation (PubMed:26126266). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex, triggering non-canonical Wnt responses such as activation of RAC1 and PI3K-AKT signaling (PubMed:26126266). Promotes apical constriction of cells via ARHGEF18 (PubMed:30948426). {ECO:0000269|PubMed:26126266, ECO:0000269|PubMed:30948426}.
Q9P241 ATP10D S613 ochoa Phospholipid-transporting ATPase VD (EC 7.6.2.1) (ATPase class V type 10D) (P4-ATPase flippase complex alpha subunit ATP10D) Catalytic component of a P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of glucosylceramide (GlcCer) from the outer to the inner leaflet of the plasma membrane. {ECO:0000269|PubMed:30530492}.
Q9UDT6 CLIP2 S160 ochoa CAP-Gly domain-containing linker protein 2 (Cytoplasmic linker protein 115) (CLIP-115) (Cytoplasmic linker protein 2) (Williams-Beuren syndrome chromosomal region 3 protein) (Williams-Beuren syndrome chromosomal region 4 protein) Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations (By similarity). {ECO:0000250}.
Q9UHV7 MED13 S483 ochoa Mediator of RNA polymerase II transcription subunit 13 (Activator-recruited cofactor 250 kDa component) (ARC250) (Mediator complex subunit 13) (Thyroid hormone receptor-associated protein 1) (Thyroid hormone receptor-associated protein complex 240 kDa component) (Trap240) (Vitamin D3 receptor-interacting protein complex component DRIP250) (DRIP250) Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:16595664}.
Q9UIF9 BAZ2A S1747 ochoa Bromodomain adjacent to zinc finger domain protein 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3) Regulatory subunit of the ATP-dependent NoRC-1 and NoRC-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Directly stimulates the ATPase activity of SMARCA5 in the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). The NoRC-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NoRC-5 ISWI chromatin remodeling complex, mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription (By similarity). Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac (By similarity). Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity). {ECO:0000250|UniProtKB:Q91YE5, ECO:0000269|PubMed:28801535}.
Q9UKE5 TNIK S560 ochoa TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1) Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:10521462, ECO:0000269|PubMed:15342639, ECO:0000269|PubMed:19061864, ECO:0000269|PubMed:19816403, ECO:0000269|PubMed:20159449, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}.
Q9ULW0 TPX2 S125 ochoa|psp Targeting protein for Xklp2 (Differentially expressed in cancerous and non-cancerous lung cells 2) (DIL-2) (Hepatocellular carcinoma-associated antigen 519) (Hepatocellular carcinoma-associated antigen 90) (Protein fls353) (Restricted expression proliferation-associated protein 100) (p100) Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764, PubMed:37728657). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activate AURKA kinase and stimulate local microtubule nucleation (PubMed:26165940). {ECO:0000269|PubMed:18663142, ECO:0000269|PubMed:19208764, ECO:0000269|PubMed:26165940}.
Q9UN30 SCML1 S150 ochoa Sex comb on midleg-like protein 1 Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. May be involved in spermatogenesis during sexual maturation (By similarity). {ECO:0000250}.
Q9UPN4 CEP131 S525 ochoa Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) (Pre-acrosome localization protein 1) Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Also acts as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). Essential for maintaining proper centriolar satellite integrity (PubMed:30804208). {ECO:0000250|UniProtKB:Q62036, ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:22797915, ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:24185901, ECO:0000269|PubMed:24550735, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:30804208}.
Q9UPT8 ZC3H4 S172 ochoa Zinc finger CCCH domain-containing protein 4 RNA-binding protein that suppresses transcription of long non-coding RNAs (lncRNAs) (PubMed:33767452, PubMed:33913806). LncRNAs are defined as transcripts more than 200 nucleotides that are not translated into protein (PubMed:33767452, PubMed:33913806). Together with WDR82, part of a transcription termination checkpoint that promotes transcription termination of lncRNAs and their subsequent degradation by the exosome (PubMed:33767452, PubMed:33913806). The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs (PubMed:33767452). {ECO:0000269|PubMed:33767452, ECO:0000269|PubMed:33913806}.
Q9Y2H6 FNDC3A S963 ochoa Fibronectin type-III domain-containing protein 3A (Human gene expressed in odontoblasts) Mediates spermatid-Sertoli adhesion during spermatogenesis. {ECO:0000250}.
Q9Y2L6 FRMD4B S675 ochoa FERM domain-containing protein 4B (GRP1-binding protein GRSP1) Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex. Plays a redundant role with FRMD4A in epithelial polarization. {ECO:0000250|UniProtKB:Q920B0}.
Q9Y2U8 LEMD3 S382 ochoa Inner nuclear membrane protein Man1 (LEM domain-containing protein 3) Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. {ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15647271}.
Q9Y450 HBS1L S205 ochoa HBS1-like protein (EC 3.6.5.-) (ERFS) GTPase component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:21448132, PubMed:23667253, PubMed:27863242). The Pelota-HBS1L complex recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel (PubMed:27863242). Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (PubMed:21448132, PubMed:32006463). {ECO:0000269|PubMed:21448132, ECO:0000269|PubMed:23667253, ECO:0000269|PubMed:27863242, ECO:0000269|PubMed:32006463}.
Q9Y485 DMXL1 S1271 ochoa DmX-like protein 1 (X-like 1 protein) None
Q9Y4D2 DAGLA S836 ochoa Diacylglycerol lipase-alpha (DAGL-alpha) (DGL-alpha) (EC 3.1.1.116) (Neural stem cell-derived dendrite regulator) (Sn1-specific diacylglycerol lipase alpha) Serine hydrolase that hydrolyzes arachidonic acid-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) (PubMed:14610053, PubMed:23502535, PubMed:26668358). Preferentially hydrolyzes sn-1 fatty acids from diacylglycerols (DAG) that contain arachidonic acid (AA) esterified at the sn-2 position to biosynthesize 2-AG (PubMed:14610053, PubMed:23502535, PubMed:26668358). Has negligible activity against other lipids including monoacylglycerols and phospholipids (PubMed:14610053). Plays a key role in regulating 2-AG signaling in the central nervous system (CNS). Regulates 2-AG involved in retrograde suppression at central synapses. Supports axonal growth during development and adult neurogenesis. Plays a role for eCB signaling in the physiological regulation of anxiety and depressive behaviors. Also regulates neuroinflammatory responses in the brain, in particular, LPS-induced microglial activation (By similarity). {ECO:0000250|UniProtKB:Q6WQJ1, ECO:0000269|PubMed:14610053, ECO:0000269|PubMed:23502535, ECO:0000269|PubMed:26668358}.
Q9Y5S2 CDC42BPB S1530 ochoa Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (CDC42BP-beta) (DMPK-like beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (MRCK beta) (Myotonic dystrophy protein kinase-like beta) Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715, PubMed:21949762). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates PPP1R12A (PubMed:21457715). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). {ECO:0000250|UniProtKB:Q7TT50, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:21949762}.
Q9Y6D5 ARFGEF2 S227 ochoa|psp Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2) (ADP-ribosylation factor guanine nucleotide-exchange factor 2) Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. {ECO:0000269|PubMed:12051703, ECO:0000269|PubMed:12571360, ECO:0000269|PubMed:15385626, ECO:0000269|PubMed:16477018, ECO:0000269|PubMed:17276987, ECO:0000269|PubMed:18625701, ECO:0000269|PubMed:20360857}.
Q9UNZ2 NSFL1C S284 Sugiyama NSFL1 cofactor p47 (UBX domain-containing protein 2C) (p97 cofactor p47) Reduces the ATPase activity of VCP (By similarity). Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro) (PubMed:15498563). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807). Also, regulates spindle orientation during mitosis (PubMed:23649807). {ECO:0000250|UniProtKB:O35987, ECO:0000269|PubMed:15498563, ECO:0000269|PubMed:23649807}.
O60479 DLX3 S137 iPTMNet|EPSD Homeobox protein DLX-3 Transcriptional activator (By similarity). Activates transcription of GNRHR, via binding to the downstream activin regulatory element (DARE) in the gene promoter (By similarity). {ECO:0000250|UniProtKB:Q64205}.
P13667 PDIA4 S124 Sugiyama Protein disulfide-isomerase A4 (EC 5.3.4.1) (Endoplasmic reticulum resident protein 70) (ER protein 70) (ERp70) (Endoplasmic reticulum resident protein 72) (ER protein 72) (ERp-72) (ERp72) None
Q12931 TRAP1 S361 Sugiyama Heat shock protein 75 kDa, mitochondrial (HSP 75) (Heat shock protein family C member 5) (TNFR-associated protein 1) (Tumor necrosis factor type 1 receptor-associated protein) (TRAP-1) Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA. {ECO:0000269|PubMed:23525905, ECO:0000269|PubMed:23564345, ECO:0000269|PubMed:23747254}.
Q92499 DDX1 S541 Sugiyama ATP-dependent RNA helicase DDX1 (EC 3.6.4.13) (DEAD box protein 1) (DEAD box protein retinoblastoma) (DBP-RB) Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 expression. Binds to the cyclin CCND2 promoter region. Associates with chromatin at the NF-kappa-B promoter region via association with RELA. Binds to poly(A) RNA. May be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB: together with archease (ZBTB8OS), acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation (PubMed:24870230). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1. Specifically binds (via helicase ATP-binding domain) on both short and long poly(I:C) dsRNA (By similarity). {ECO:0000250|UniProtKB:Q91VR5, ECO:0000269|PubMed:12183465, ECO:0000269|PubMed:15567440, ECO:0000269|PubMed:18335541, ECO:0000269|PubMed:18710941, ECO:0000269|PubMed:20573827, ECO:0000269|PubMed:24870230}.; FUNCTION: (Microbial infection) Required for HIV-1 Rev function as well as for HIV-1 and coronavirus IBV replication. Binds to the RRE sequence of HIV-1 mRNAs. {ECO:0000269|PubMed:15567440}.; FUNCTION: (Microbial infection) Required for Coronavirus IBV replication. {ECO:0000269|PubMed:20573827}.
O75376 NCOR1 S2164 Sugiyama Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}.
Q9NZ52 GGA3 S415 Sugiyama ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3) Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:11301005). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:26811329). nvolved in BACE1 transport and sorting as well as regulation of BACE1 protein levels (PubMed:15615712, PubMed:17553422, PubMed:20484053). Regulates retrograde transport of BACE1 from endosomes to the trans-Golgi network via interaction through the VHS motif and dependent of BACE1 phosphorylation (PubMed:15615712). Modulates BACE1 protein levels independently of the interaction between VHS domain and DXXLL motif through recognition of ubiquitination (PubMed:20484053). Key player in a novel DXXLL-mediated endosomal sorting machinery to the recycling pathway that targets NTRK1 to the plasma membrane (By similarity). {ECO:0000250|UniProtKB:A0A0G2JV04, ECO:0000269|PubMed:11301005, ECO:0000269|PubMed:15615712, ECO:0000269|PubMed:17553422, ECO:0000269|PubMed:20484053, ECO:0000269|PubMed:26811329}.
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reactome_id name p -log10_p
R-HSA-212165 Epigenetic regulation of gene expression 0.000005 5.266
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 0.000020 4.694
R-HSA-69278 Cell Cycle, Mitotic 0.000021 4.672
R-HSA-9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 0.000050 4.303
R-HSA-1640170 Cell Cycle 0.000042 4.377
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 0.000156 3.808
R-HSA-1989781 PPARA activates gene expression 0.000122 3.915
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 0.000132 3.878
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 0.000155 3.810
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 0.000155 3.810
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 0.000155 3.810
R-HSA-2980766 Nuclear Envelope Breakdown 0.000083 4.081
R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 0.000134 3.874
R-HSA-68886 M Phase 0.000132 3.881
R-HSA-68875 Mitotic Prophase 0.000115 3.939
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 0.000178 3.749
R-HSA-9843745 Adipogenesis 0.000215 3.668
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 0.000393 3.405
R-HSA-2197563 NOTCH2 intracellular domain regulates transcription 0.000733 3.135
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 0.000667 3.176
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 0.000738 3.132
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 0.000738 3.132
R-HSA-1855170 IPs transport between nucleus and cytosol 0.000896 3.048
R-HSA-159227 Transport of the SLBP independent Mature mRNA 0.000896 3.048
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 0.000983 3.008
R-HSA-3371556 Cellular response to heat stress 0.000707 3.151
R-HSA-191859 snRNP Assembly 0.000852 3.070
R-HSA-194441 Metabolism of non-coding RNA 0.000852 3.070
R-HSA-168325 Viral Messenger RNA Synthesis 0.000970 3.013
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 0.000983 3.008
R-HSA-9707616 Heme signaling 0.001033 2.986
R-HSA-6803211 TP53 Regulates Transcription of Death Receptors and Ligands 0.001028 2.988
R-HSA-180746 Nuclear import of Rev protein 0.001076 2.968
R-HSA-6784531 tRNA processing in the nucleus 0.001033 2.986
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 0.001175 2.930
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 0.001175 2.930
R-HSA-9909396 Circadian clock 0.001198 2.921
R-HSA-180910 Vpr-mediated nuclear import of PICs 0.001392 2.856
R-HSA-9018519 Estrogen-dependent gene expression 0.001447 2.840
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 0.001510 2.821
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 0.001636 2.786
R-HSA-168276 NS1 Mediated Effects on Host Pathways 0.001636 2.786
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 0.001768 2.753
R-HSA-177243 Interactions of Rev with host cellular proteins 0.001768 2.753
R-HSA-176033 Interactions of Vpr with host cellular proteins 0.001768 2.753
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 0.001907 2.720
R-HSA-9024446 NR1H2 and NR1H3-mediated signaling 0.002400 2.620
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 0.002720 2.565
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 0.002907 2.536
R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription 0.002909 2.536
R-HSA-350054 Notch-HLH transcription pathway 0.003577 2.446
R-HSA-1912408 Pre-NOTCH Transcription and Translation 0.004760 2.322
R-HSA-70171 Glycolysis 0.007306 2.136
R-HSA-74160 Gene expression (Transcription) 0.007378 2.132
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 0.007854 2.105
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 0.008729 2.059
R-HSA-5619507 Activation of HOX genes during differentiation 0.008729 2.059
R-HSA-162599 Late Phase of HIV Life Cycle 0.008053 2.094
R-HSA-9006931 Signaling by Nuclear Receptors 0.008889 2.051
R-HSA-1980145 Signaling by NOTCH2 0.010151 1.994
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian expression 0.010151 1.994
R-HSA-163765 ChREBP activates metabolic gene expression 0.010191 1.992
R-HSA-5578749 Transcriptional regulation by small RNAs 0.011312 1.946
R-HSA-9623433 NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis 0.011617 1.935
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.011792 1.928
R-HSA-8941856 RUNX3 regulates NOTCH signaling 0.013125 1.882
R-HSA-1980143 Signaling by NOTCH1 0.013308 1.876
R-HSA-162587 HIV Life Cycle 0.012110 1.917
R-HSA-1912422 Pre-NOTCH Expression and Processing 0.011754 1.930
R-HSA-1169408 ISG15 antiviral mechanism 0.012789 1.893
R-HSA-70326 Glucose metabolism 0.014125 1.850
R-HSA-9818030 NFE2L2 regulating tumorigenic genes 0.014714 1.832
R-HSA-162658 Golgi Cisternae Pericentriolar Stack Reorganization 0.014714 1.832
R-HSA-9029558 NR1H2 & NR1H3 regulate gene expression linked to lipogenesis 0.014714 1.832
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 0.016101 1.793
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 0.019236 1.716
R-HSA-141424 Amplification of signal from the kinetochores 0.019236 1.716
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 0.016700 1.777
R-HSA-73762 RNA Polymerase I Transcription Initiation 0.017171 1.765
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 0.017940 1.746
R-HSA-9735871 SARS-CoV-1 targets host intracellular signalling and regulatory pathways 0.018126 1.742
R-HSA-9707564 Cytoprotection by HMOX1 0.017313 1.762
R-HSA-210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic... 0.019944 1.700
R-HSA-9709275 Impaired BRCA2 translocation to the nucleus 0.021259 1.672
R-HSA-9763198 Impaired BRCA2 binding to SEM1 (DSS1) 0.021259 1.672
R-HSA-9675151 Disorders of Developmental Biology 0.021836 1.661
R-HSA-8939211 ESR-mediated signaling 0.021854 1.660
R-HSA-157118 Signaling by NOTCH 0.023092 1.637
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 0.024105 1.618
R-HSA-69275 G2/M Transition 0.024172 1.617
R-HSA-453274 Mitotic G2-G2/M phases 0.025187 1.599
R-HSA-4419969 Depolymerization of the Nuclear Lamina 0.025832 1.588
R-HSA-3371571 HSF1-dependent transactivation 0.026325 1.580
R-HSA-5678420 Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome 0.031719 1.499
R-HSA-5545619 XAV939 stabilizes AXIN 0.031719 1.499
R-HSA-5619111 Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) 0.031719 1.499
R-HSA-9636667 Manipulation of host energy metabolism 0.031719 1.499
R-HSA-68877 Mitotic Prometaphase 0.027846 1.555
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.030961 1.509
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 0.032336 1.490
R-HSA-162582 Signal Transduction 0.032422 1.489
R-HSA-69618 Mitotic Spindle Checkpoint 0.032587 1.487
R-HSA-2995383 Initiation of Nuclear Envelope (NE) Reformation 0.034626 1.461
R-HSA-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... 0.034925 1.457
R-HSA-167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 0.039397 1.405
R-HSA-77075 RNA Pol II CTD phosphorylation and interaction with CE 0.039397 1.405
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 0.037618 1.425
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 0.037618 1.425
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 0.037618 1.425
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 0.037618 1.425
R-HSA-446343 Localization of the PINCH-ILK-PARVIN complex to focal adhesions 0.042068 1.376
R-HSA-68882 Mitotic Anaphase 0.043174 1.365
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.043908 1.357
R-HSA-2644603 Signaling by NOTCH1 in Cancer 0.037618 1.425
R-HSA-200425 Carnitine shuttle 0.039397 1.405
R-HSA-9839394 TGFBR3 expression 0.044402 1.353
R-HSA-168273 Influenza Viral RNA Transcription and Replication 0.039900 1.399
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 0.042450 1.372
R-HSA-211000 Gene Silencing by RNA 0.040357 1.394
R-HSA-1483249 Inositol phosphate metabolism 0.045703 1.340
R-HSA-9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... 0.046988 1.328
R-HSA-5685942 HDR through Homologous Recombination (HRR) 0.047848 1.320
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 0.049410 1.306
R-HSA-73863 RNA Polymerase I Transcription Termination 0.049628 1.304
R-HSA-1483213 Synthesis of PE 0.049628 1.304
R-HSA-75157 FasL/ CD95L signaling 0.052307 1.281
R-HSA-9944997 Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome 0.052307 1.281
R-HSA-9944971 Loss of Function of KMT2D in Kabuki Syndrome 0.052307 1.281
R-HSA-9818035 NFE2L2 regulating ER-stress associated genes 0.062438 1.205
R-HSA-5083630 Defective LFNG causes SCDO3 0.062438 1.205
R-HSA-167158 Formation of the HIV-1 Early Elongation Complex 0.052321 1.281
R-HSA-113418 Formation of the Early Elongation Complex 0.052321 1.281
R-HSA-9709570 Impaired BRCA2 binding to RAD51 0.055064 1.259
R-HSA-72086 mRNA Capping 0.055064 1.259
R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription 0.057857 1.238
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 0.054245 1.266
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates 0.066521 1.177
R-HSA-73864 RNA Polymerase I Transcription 0.066365 1.178
R-HSA-73854 RNA Polymerase I Promoter Clearance 0.062785 1.202
R-HSA-427413 NoRC negatively regulates rRNA expression 0.054245 1.266
R-HSA-5368598 Negative regulation of TCF-dependent signaling by DVL-interacting proteins 0.052307 1.281
R-HSA-1296025 ATP sensitive Potassium channels 0.062438 1.205
R-HSA-9930044 Nuclear RNA decay 0.066521 1.177
R-HSA-9013694 Signaling by NOTCH4 0.059297 1.227
R-HSA-162906 HIV Infection 0.051679 1.287
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 0.058788 1.231
R-HSA-5675482 Regulation of necroptotic cell death 0.066521 1.177
R-HSA-8878171 Transcriptional regulation by RUNX1 0.050866 1.294
R-HSA-4791275 Signaling by WNT in cancer 0.063587 1.197
R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes 0.061029 1.214
R-HSA-168255 Influenza Infection 0.063678 1.196
R-HSA-3247509 Chromatin modifying enzymes 0.057589 1.240
R-HSA-162909 Host Interactions of HIV factors 0.062669 1.203
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 0.066521 1.177
R-HSA-1592230 Mitochondrial biogenesis 0.053820 1.269
R-HSA-72306 tRNA processing 0.054365 1.265
R-HSA-5619102 SLC transporter disorders 0.050498 1.297
R-HSA-201681 TCF dependent signaling in response to WNT 0.068088 1.167
R-HSA-5693537 Resolution of D-Loop Structures 0.069499 1.158
R-HSA-8964539 Glutamate and glutamine metabolism 0.069499 1.158
R-HSA-5619115 Disorders of transmembrane transporters 0.069604 1.157
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 0.070037 1.155
R-HSA-5250941 Negative epigenetic regulation of rRNA expression 0.070037 1.155
R-HSA-4839726 Chromatin organization 0.071572 1.145
R-HSA-9818026 NFE2L2 regulating inflammation associated genes 0.072460 1.140
R-HSA-3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 0.072460 1.140
R-HSA-9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function 0.072520 1.140
R-HSA-9675136 Diseases of DNA Double-Strand Break Repair 0.072520 1.140
R-HSA-5340588 Signaling by RNF43 mutants 0.082376 1.084
R-HSA-9022537 Loss of MECP2 binding ability to the NCoR/SMRT complex 0.082376 1.084
R-HSA-1912399 Pre-NOTCH Processing in the Endoplasmic Reticulum 0.101894 0.992
R-HSA-196025 Formation of annular gap junctions 0.111497 0.953
R-HSA-8875656 MET receptor recycling 0.111497 0.953
R-HSA-3371568 Attenuation phase 0.091484 1.039
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat 0.091484 1.039
R-HSA-167162 RNA Polymerase II HIV Promoter Escape 0.098095 1.008
R-HSA-167161 HIV Transcription Initiation 0.098095 1.008
R-HSA-75953 RNA Polymerase II Transcription Initiation 0.098095 1.008
R-HSA-73776 RNA Polymerase II Promoter Escape 0.104837 0.979
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 0.083587 1.078
R-HSA-167169 HIV Transcription Elongation 0.091484 1.039
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript 0.091484 1.039
R-HSA-8937144 Aryl hydrocarbon receptor signalling 0.082376 1.084
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat 0.088230 1.054
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 0.075583 1.122
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange 0.085011 1.071
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 0.091484 1.039
R-HSA-9844594 Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 0.091484 1.039
R-HSA-9843743 Transcriptional regulation of brown and beige adipocyte differentiation 0.091484 1.039
R-HSA-3371378 Regulation by c-FLIP 0.111497 0.953
R-HSA-446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... 0.082376 1.084
R-HSA-139915 Activation of PUMA and translocation to mitochondria 0.101894 0.992
R-HSA-1253288 Downregulation of ERBB4 signaling 0.111497 0.953
R-HSA-8941855 RUNX3 regulates CDKN1A transcription 0.082376 1.084
R-HSA-69416 Dimerization of procaspase-8 0.111497 0.953
R-HSA-9711123 Cellular response to chemical stress 0.091852 1.037
R-HSA-8878159 Transcriptional regulation by RUNX3 0.111418 0.953
R-HSA-9818749 Regulation of NFE2L2 gene expression 0.092187 1.035
R-HSA-6802957 Oncogenic MAPK signaling 0.079608 1.099
R-HSA-427652 Sodium-coupled phosphate cotransporters 0.082376 1.084
R-HSA-8849469 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 0.111497 0.953
R-HSA-9609690 HCMV Early Events 0.083562 1.078
R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 0.081830 1.087
R-HSA-2262752 Cellular responses to stress 0.094290 1.026
R-HSA-5213460 RIPK1-mediated regulated necrosis 0.085011 1.071
R-HSA-3214841 PKMTs methylate histone lysines 0.094773 1.023
R-HSA-170834 Signaling by TGF-beta Receptor Complex 0.111418 0.953
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 0.108255 0.966
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 0.095069 1.022
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance 0.111701 0.952
R-HSA-9818032 NFE2L2 regulating MDR associated enzymes 0.120998 0.917
R-HSA-190873 Gap junction degradation 0.120998 0.917
R-HSA-5218900 CASP8 activity is inhibited 0.120998 0.917
R-HSA-9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters 0.148900 0.827
R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex 0.202088 0.694
R-HSA-1912420 Pre-NOTCH Processing in Golgi 0.227430 0.643
R-HSA-167242 Abortive elongation of HIV-1 transcript in the absence of Tat 0.227430 0.643
R-HSA-9709603 Impaired BRCA2 binding to PALB2 0.227430 0.643
R-HSA-73772 RNA Polymerase I Promoter Escape 0.136570 0.865
R-HSA-112382 Formation of RNA Pol II elongation complex 0.136570 0.865
R-HSA-75955 RNA Polymerase II Transcription Elongation 0.140217 0.853
R-HSA-5250924 B-WICH complex positively regulates rRNA expression 0.140217 0.853
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 0.185386 0.732
R-HSA-8854518 AURKA Activation by TPX2 0.189244 0.723
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 0.216517 0.665
R-HSA-380287 Centrosome maturation 0.224378 0.649
R-HSA-167172 Transcription of the HIV genome 0.196991 0.706
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.220243 0.657
R-HSA-8951936 RUNX3 regulates p14-ARF 0.158003 0.801
R-HSA-9931521 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... 0.202088 0.694
R-HSA-2025928 Calcineurin activates NFAT 0.120998 0.917
R-HSA-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anapha... 0.202088 0.694
R-HSA-674695 RNA Polymerase II Pre-transcription Events 0.220444 0.657
R-HSA-3214815 HDACs deacetylate histones 0.147574 0.831
R-HSA-1234158 Regulation of gene expression by Hypoxia-inducible Factor 0.148900 0.827
R-HSA-9012852 Signaling by NOTCH3 0.147574 0.831
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 0.154815 0.810
R-HSA-2468052 Establishment of Sister Chromatid Cohesion 0.130398 0.885
R-HSA-9818028 NFE2L2 regulates pentose phosphate pathway genes 0.148900 0.827
R-HSA-5607763 CLEC7A (Dectin-1) induces NFAT activation 0.175921 0.755
R-HSA-4641263 Regulation of FZD by ubiquitination 0.210626 0.676
R-HSA-8851708 Signaling by FGFR2 IIIa TM 0.227430 0.643
R-HSA-9925563 Developmental Lineage of Pancreatic Ductal Cells 0.200879 0.697
R-HSA-5693538 Homology Directed Repair 0.170312 0.769
R-HSA-9617629 Regulation of FOXO transcriptional activity by acetylation 0.158003 0.801
R-HSA-140534 Caspase activation via Death Receptors in the presence of ligand 0.193459 0.713
R-HSA-426048 Arachidonate production from DAG 0.130398 0.885
R-HSA-9754706 Atorvastatin ADME 0.193459 0.713
R-HSA-430039 mRNA decay by 5' to 3' exoribonuclease 0.202088 0.694
R-HSA-6804760 Regulation of TP53 Activity through Methylation 0.219073 0.659
R-HSA-429958 mRNA decay by 3' to 5' exoribonuclease 0.227430 0.643
R-HSA-446353 Cell-extracellular matrix interactions 0.184737 0.733
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 0.115176 0.939
R-HSA-9649948 Signaling downstream of RAS mutants 0.115176 0.939
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 0.115176 0.939
R-HSA-918233 TRAF3-dependent IRF activation pathway 0.202088 0.694
R-HSA-4086398 Ca2+ pathway 0.216517 0.665
R-HSA-8866907 Activation of the TFAP2 (AP-2) family of transcription factors 0.120998 0.917
R-HSA-428540 Activation of RAC1 0.148900 0.827
R-HSA-6811555 PI5P Regulates TP53 Acetylation 0.167010 0.777
R-HSA-2467813 Separation of Sister Chromatids 0.133848 0.873
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 0.158751 0.799
R-HSA-8953854 Metabolism of RNA 0.211383 0.675
R-HSA-6802949 Signaling by RAS mutants 0.115176 0.939
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 0.189244 0.723
R-HSA-9762293 Regulation of CDH11 gene transcription 0.120998 0.917
R-HSA-9675135 Diseases of DNA repair 0.115176 0.939
R-HSA-9005891 Loss of function of MECP2 in Rett syndrome 0.158003 0.801
R-HSA-9697154 Disorders of Nervous System Development 0.158003 0.801
R-HSA-9005895 Pervasive developmental disorders 0.158003 0.801
R-HSA-3270619 IRF3-mediated induction of type I IFN 0.184737 0.733
R-HSA-9614657 FOXO-mediated transcription of cell death genes 0.219073 0.659
R-HSA-429914 Deadenylation-dependent mRNA decay 0.162512 0.789
R-HSA-8953897 Cellular responses to stimuli 0.124014 0.907
R-HSA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 0.202088 0.694
R-HSA-211981 Xenobiotics 0.181541 0.741
R-HSA-449836 Other interleukin signaling 0.227430 0.643
R-HSA-388844 Receptor-type tyrosine-protein phosphatases 0.193459 0.713
R-HSA-211976 Endogenous sterols 0.170080 0.769
R-HSA-9609646 HCMV Infection 0.166819 0.778
R-HSA-1236394 Signaling by ERBB4 0.220444 0.657
R-HSA-195721 Signaling by WNT 0.129514 0.888
R-HSA-9764790 Positive Regulation of CDH1 Gene Transcription 0.130398 0.885
R-HSA-9027307 Biosynthesis of maresin-like SPMs 0.202088 0.694
R-HSA-156711 Polo-like kinase mediated events 0.219073 0.659
R-HSA-1852241 Organelle biogenesis and maintenance 0.161183 0.793
R-HSA-5685939 HDR through MMEJ (alt-NHEJ) 0.167010 0.777
R-HSA-5633007 Regulation of TP53 Activity 0.126365 0.898
R-HSA-1483191 Synthesis of PC 0.118679 0.926
R-HSA-198323 AKT phosphorylates targets in the cytosol 0.158003 0.801
R-HSA-9616222 Transcriptional regulation of granulopoiesis 0.173887 0.760
R-HSA-69620 Cell Cycle Checkpoints 0.181012 0.742
R-HSA-1834941 STING mediated induction of host immune responses 0.227430 0.643
R-HSA-9610379 HCMV Late Events 0.120874 0.918
R-HSA-6804759 Regulation of TP53 Activity through Association with Co-factors 0.167010 0.777
R-HSA-212436 Generic Transcription Pathway 0.176590 0.753
R-HSA-8957322 Metabolism of steroids 0.167276 0.777
R-HSA-3700989 Transcriptional Regulation by TP53 0.154367 0.811
R-HSA-5218859 Regulated Necrosis 0.196991 0.706
R-HSA-9701898 STAT3 nuclear events downstream of ALK signaling 0.184737 0.733
R-HSA-9839373 Signaling by TGFBR3 0.115176 0.939
R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activ... 0.208683 0.681
R-HSA-9833110 RSV-host interactions 0.130078 0.886
R-HSA-9793380 Formation of paraxial mesoderm 0.170080 0.769
R-HSA-5357801 Programmed Cell Death 0.224023 0.650
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 0.204777 0.689
R-HSA-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... 0.202088 0.694
R-HSA-75205 Dissolution of Fibrin Clot 0.139698 0.855
R-HSA-9692914 SARS-CoV-1-host interactions 0.134907 0.870
R-HSA-186712 Regulation of beta-cell development 0.162512 0.789
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... 0.185386 0.732
R-HSA-9679506 SARS-CoV Infections 0.169140 0.772
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.115489 0.937
R-HSA-9020591 Interleukin-12 signaling 0.228316 0.641
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 0.230372 0.638
R-HSA-9701193 Defective homologous recombination repair (HRR) due to PALB2 loss of function 0.235698 0.628
R-HSA-9701192 Defective homologous recombination repair (HRR) due to BRCA1 loss of function 0.235698 0.628
R-HSA-9704646 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 0.235698 0.628
R-HSA-9704331 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 0.235698 0.628
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse 0.235698 0.628
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 0.236208 0.627
R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A 0.243878 0.613
R-HSA-2979096 NOTCH2 Activation and Transmission of Signal to the Nucleus 0.243878 0.613
R-HSA-9819196 Zygotic genome activation (ZGA) 0.243878 0.613
R-HSA-6803529 FGFR2 alternative splicing 0.259978 0.585
R-HSA-166208 mTORC1-mediated signalling 0.259978 0.585
R-HSA-6803205 TP53 regulates transcription of several additional cell death genes whose specif... 0.259978 0.585
R-HSA-6794362 Protein-protein interactions at synapses 0.263919 0.579
R-HSA-9018682 Biosynthesis of maresins 0.267900 0.572
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer 0.267900 0.572
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 0.271847 0.566
R-HSA-381038 XBP1(S) activates chaperone genes 0.271847 0.566
R-HSA-9865881 Complex III assembly 0.275737 0.560
R-HSA-5621575 CD209 (DC-SIGN) signaling 0.275737 0.560
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... 0.275737 0.560
R-HSA-8863678 Neurodegenerative Diseases 0.275737 0.560
R-HSA-447115 Interleukin-12 family signaling 0.275810 0.559
R-HSA-9705683 SARS-CoV-2-host interactions 0.277485 0.557
R-HSA-5693532 DNA Double-Strand Break Repair 0.279099 0.554
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 0.279772 0.553
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... 0.283491 0.547
R-HSA-400685 Sema4D in semaphorin signaling 0.283491 0.547
R-HSA-9703465 Signaling by FLT3 fusion proteins 0.291162 0.536
R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation 0.291162 0.536
R-HSA-5357769 Caspase activation via extrinsic apoptotic signalling pathway 0.291162 0.536
R-HSA-2122948 Activated NOTCH1 Transmits Signal to the Nucleus 0.291162 0.536
R-HSA-5689901 Metalloprotease DUBs 0.291162 0.536
R-HSA-3295583 TRP channels 0.291162 0.536
R-HSA-381070 IRE1alpha activates chaperones 0.295600 0.529
R-HSA-73857 RNA Polymerase II Transcription 0.296269 0.528
R-HSA-167243 Tat-mediated HIV elongation arrest and recovery 0.298752 0.525
R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation 0.298752 0.525
R-HSA-9841251 Mitochondrial unfolded protein response (UPRmt) 0.298752 0.525
R-HSA-3928663 EPHA-mediated growth cone collapse 0.298752 0.525
R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 0.298752 0.525
R-HSA-75109 Triglyceride biosynthesis 0.298752 0.525
R-HSA-9734009 Defective Intrinsic Pathway for Apoptosis 0.298752 0.525
R-HSA-193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol 0.298752 0.525
R-HSA-9006936 Signaling by TGFB family members 0.299470 0.524
R-HSA-109581 Apoptosis 0.305308 0.515
R-HSA-167287 HIV elongation arrest and recovery 0.306261 0.514
R-HSA-167290 Pausing and recovery of HIV elongation 0.306261 0.514
R-HSA-9757110 Prednisone ADME 0.306261 0.514
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 0.311380 0.507
R-HSA-180024 DARPP-32 events 0.313690 0.503
R-HSA-9759475 Regulation of CDH11 Expression and Function 0.313690 0.503
R-HSA-1296071 Potassium Channels 0.319243 0.496
R-HSA-211897 Cytochrome P450 - arranged by substrate type 0.319922 0.495
R-HSA-114452 Activation of BH3-only proteins 0.321040 0.493
R-HSA-9833109 Evasion by RSV of host interferon responses 0.328312 0.484
R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling 0.328312 0.484
R-HSA-3214847 HATs acetylate histones 0.330998 0.480
R-HSA-1296065 Inwardly rectifying K+ channels 0.335506 0.474
R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity 0.335506 0.474
R-HSA-111465 Apoptotic cleavage of cellular proteins 0.335506 0.474
R-HSA-5685938 HDR through Single Strand Annealing (SSA) 0.342624 0.465
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... 0.342624 0.465
R-HSA-6804758 Regulation of TP53 Activity through Acetylation 0.342624 0.465
R-HSA-159418 Recycling of bile acids and salts 0.342624 0.465
R-HSA-9764260 Regulation of Expression and Function of Type II Classical Cadherins 0.342624 0.465
R-HSA-9022692 Regulation of MECP2 expression and activity 0.342624 0.465
R-HSA-9842860 Regulation of endogenous retroelements 0.342697 0.465
R-HSA-2559580 Oxidative Stress Induced Senescence 0.342697 0.465
R-HSA-9678108 SARS-CoV-1 Infection 0.346238 0.461
R-HSA-9818027 NFE2L2 regulating anti-oxidant/detoxification enzymes 0.349665 0.456
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis 0.349665 0.456
R-HSA-114508 Effects of PIP2 hydrolysis 0.349665 0.456
R-HSA-199220 Vitamin B5 (pantothenate) metabolism 0.349665 0.456
R-HSA-9824446 Viral Infection Pathways 0.351327 0.454
R-HSA-9843970 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 0.356632 0.448
R-HSA-5673000 RAF activation 0.356632 0.448
R-HSA-168638 NOD1/2 Signaling Pathway 0.356632 0.448
R-HSA-2559583 Cellular Senescence 0.360827 0.443
R-HSA-9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... 0.363525 0.439
R-HSA-2559585 Oncogene Induced Senescence 0.363525 0.439
R-HSA-3371511 HSF1 activation 0.370344 0.431
R-HSA-9682385 FLT3 signaling in disease 0.370344 0.431
R-HSA-1839126 FGFR2 mutant receptor activation 0.370344 0.431
R-HSA-8853659 RET signaling 0.370344 0.431
R-HSA-1296072 Voltage gated Potassium channels 0.377090 0.424
R-HSA-4641257 Degradation of AXIN 0.377090 0.424
R-HSA-933541 TRAF6 mediated IRF7 activation 0.377090 0.424
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 0.377090 0.424
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 0.377090 0.424
R-HSA-9958790 SLC-mediated transport of inorganic anions 0.383765 0.416
R-HSA-201556 Signaling by ALK 0.390369 0.409
R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 0.396902 0.401
R-HSA-5696395 Formation of Incision Complex in GG-NER 0.396902 0.401
R-HSA-1251985 Nuclear signaling by ERBB4 0.396902 0.401
R-HSA-9646399 Aggrephagy 0.396902 0.401
R-HSA-8941858 Regulation of RUNX3 expression and activity 0.396902 0.401
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 0.403365 0.394
R-HSA-5423646 Aflatoxin activation and detoxification 0.403365 0.394
R-HSA-5610780 Degradation of GLI1 by the proteasome 0.409760 0.387
R-HSA-6811438 Intra-Golgi traffic 0.409760 0.387
R-HSA-5674135 MAP2K and MAPK activation 0.409760 0.387
R-HSA-5675221 Negative regulation of MAPK pathway 0.409760 0.387
R-HSA-9007101 Rab regulation of trafficking 0.411284 0.386
R-HSA-165159 MTOR signalling 0.416087 0.381
R-HSA-8854214 TBC/RABGAPs 0.422346 0.374
R-HSA-9637690 Response of Mtb to phagocytosis 0.422346 0.374
R-HSA-9759194 Nuclear events mediated by NFE2L2 0.426066 0.371
R-HSA-1483206 Glycerophospholipid biosynthesis 0.427072 0.369
R-HSA-190828 Gap junction trafficking 0.428538 0.368
R-HSA-3928662 EPHB-mediated forward signaling 0.428538 0.368
R-HSA-69236 G1 Phase 0.428538 0.368
R-HSA-69231 Cyclin D associated events in G1 0.428538 0.368
R-HSA-9816359 Maternal to zygotic transition (MZT) 0.433386 0.363
R-HSA-6783310 Fanconi Anemia Pathway 0.434665 0.362
R-HSA-6781823 Formation of TC-NER Pre-Incision Complex 0.440726 0.356
R-HSA-72165 mRNA Splicing - Minor Pathway 0.440726 0.356
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 0.440726 0.356
R-HSA-75153 Apoptotic execution phase 0.440726 0.356
R-HSA-9031628 NGF-stimulated transcription 0.452655 0.344
R-HSA-5620924 Intraflagellar transport 0.452655 0.344
R-HSA-70263 Gluconeogenesis 0.452655 0.344
R-HSA-556833 Metabolism of lipids 0.456011 0.341
R-HSA-157858 Gap junction trafficking and regulation 0.458524 0.339
R-HSA-5655253 Signaling by FGFR2 in disease 0.464331 0.333
R-HSA-912446 Meiotic recombination 0.470076 0.328
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 0.475759 0.323
R-HSA-6794361 Neurexins and neuroligins 0.475759 0.323
R-HSA-9692916 SARS-CoV-1 activates/modulates innate immune responses 0.475759 0.323
R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... 0.481382 0.318
R-HSA-432722 Golgi Associated Vesicle Biogenesis 0.481382 0.318
R-HSA-8948751 Regulation of PTEN stability and activity 0.481382 0.318
R-HSA-445355 Smooth Muscle Contraction 0.481382 0.318
R-HSA-72649 Translation initiation complex formation 0.486945 0.313
R-HSA-3858494 Beta-catenin independent WNT signaling 0.490055 0.310
R-HSA-163685 Integration of energy metabolism 0.490055 0.310
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 0.492449 0.308
R-HSA-72702 Ribosomal scanning and start codon recognition 0.497894 0.303
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER 0.497894 0.303
R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 0.497894 0.303
R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea 0.497894 0.303
R-HSA-5578775 Ion homeostasis 0.497894 0.303
R-HSA-109606 Intrinsic Pathway for Apoptosis 0.497894 0.303
R-HSA-6807070 PTEN Regulation 0.500284 0.301
R-HSA-381119 Unfolded Protein Response (UPR) 0.500284 0.301
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 0.503281 0.298
R-HSA-6782135 Dual incision in TC-NER 0.508610 0.294
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... 0.508610 0.294
R-HSA-8979227 Triglyceride metabolism 0.513883 0.289
R-HSA-8856828 Clathrin-mediated endocytosis 0.517039 0.286
R-HSA-9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 0.519099 0.285
R-HSA-983189 Kinesins 0.519099 0.285
R-HSA-8943724 Regulation of PTEN gene transcription 0.519099 0.285
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 0.529365 0.276
R-HSA-1268020 Mitochondrial protein import 0.529365 0.276
R-HSA-69242 S Phase 0.533421 0.273
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 0.534416 0.272
R-HSA-380259 Loss of Nlp from mitotic centrosomes 0.534416 0.272
R-HSA-373755 Semaphorin interactions 0.534416 0.272
R-HSA-8848021 Signaling by PTK6 0.534416 0.272
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 0.534416 0.272
R-HSA-9758941 Gastrulation 0.536652 0.270
R-HSA-936837 Ion transport by P-type ATPases 0.539414 0.268
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... 0.539414 0.268
R-HSA-9679191 Potential therapeutics for SARS 0.539867 0.268
R-HSA-9755511 KEAP1-NFE2L2 pathway 0.543067 0.265
R-HSA-1234174 Cellular response to hypoxia 0.544358 0.264
R-HSA-9820448 Developmental Cell Lineages of the Exocrine Pancreas 0.546252 0.263
R-HSA-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 0.554088 0.256
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 0.558875 0.253
R-HSA-9694516 SARS-CoV-2 Infection 0.561728 0.250
R-HSA-9843940 Regulation of endogenous retroelements by KRAB-ZFP proteins 0.568297 0.245
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 0.568297 0.245
R-HSA-75105 Fatty acyl-CoA biosynthesis 0.568297 0.245
R-HSA-69202 Cyclin E associated events during G1/S transition 0.568297 0.245
R-HSA-9764560 Regulation of CDH1 Gene Transcription 0.568297 0.245
R-HSA-453276 Regulation of mitotic cell cycle 0.572932 0.242
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 0.572932 0.242
R-HSA-3906995 Diseases associated with O-glycosylation of proteins 0.572932 0.242
R-HSA-5632684 Hedgehog 'on' state 0.572932 0.242
R-HSA-199992 trans-Golgi Network Vesicle Budding 0.577518 0.238
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 0.577518 0.238
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 0.577518 0.238
R-HSA-9749641 Aspirin ADME 0.582055 0.235
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 0.582116 0.235
R-HSA-1643685 Disease 0.583428 0.234
R-HSA-73894 DNA Repair 0.584948 0.233
R-HSA-69473 G2/M DNA damage checkpoint 0.586544 0.232
R-HSA-1226099 Signaling by FGFR in disease 0.586544 0.232
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 0.590985 0.228
R-HSA-71403 Citric acid cycle (TCA cycle) 0.590985 0.228
R-HSA-383280 Nuclear Receptor transcription pathway 0.604025 0.219
R-HSA-416482 G alpha (12/13) signalling events 0.604025 0.219
R-HSA-4086400 PCP/CE pathway 0.604025 0.219
R-HSA-5619084 ABC transporter disorders 0.604025 0.219
R-HSA-5621481 C-type lectin receptors (CLRs) 0.606678 0.217
R-HSA-9659379 Sensory processing of sound 0.608279 0.216
R-HSA-9909648 Regulation of PD-L1(CD274) expression 0.609535 0.215
R-HSA-5654738 Signaling by FGFR2 0.612487 0.213
R-HSA-6806834 Signaling by MET 0.612487 0.213
R-HSA-5693607 Processing of DNA double-strand break ends 0.616651 0.210
R-HSA-977225 Amyloid fiber formation 0.616651 0.210
R-HSA-9018677 Biosynthesis of DHA-derived SPMs 0.616651 0.210
R-HSA-211945 Phase I - Functionalization of compounds 0.622754 0.206
R-HSA-611105 Respiratory electron transport 0.626346 0.203
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 0.628877 0.201
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 0.628877 0.201
R-HSA-1500620 Meiosis 0.632865 0.199
R-HSA-913531 Interferon Signaling 0.633076 0.199
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 0.636811 0.196
R-HSA-1266738 Developmental Biology 0.639005 0.194
R-HSA-390466 Chaperonin-mediated protein folding 0.644577 0.191
R-HSA-9645723 Diseases of programmed cell death 0.648398 0.188
R-HSA-9663891 Selective autophagy 0.648398 0.188
R-HSA-983712 Ion channel transport 0.655707 0.183
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 0.655917 0.183
R-HSA-373080 Class B/2 (Secretin family receptors) 0.655917 0.183
R-HSA-5617833 Cilium Assembly 0.658284 0.182
R-HSA-9954714 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA 0.659617 0.181
R-HSA-8986944 Transcriptional Regulation by MECP2 0.659617 0.181
R-HSA-1257604 PIP3 activates AKT signaling 0.659848 0.181
R-HSA-1483257 Phospholipid metabolism 0.659848 0.181
R-HSA-2682334 EPH-Ephrin signaling 0.666898 0.176
R-HSA-391251 Protein folding 0.666898 0.176
R-HSA-9837999 Mitochondrial protein degradation 0.674024 0.171
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.679444 0.168
R-HSA-72689 Formation of a pool of free 40S subunits 0.680998 0.167
R-HSA-389948 Co-inhibition by PD-1 0.683210 0.165
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 0.683210 0.165
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 0.684430 0.165
R-HSA-5607764 CLEC7A (Dectin-1) signaling 0.684430 0.165
R-HSA-190236 Signaling by FGFR 0.691183 0.160
R-HSA-9614085 FOXO-mediated transcription 0.694505 0.158
R-HSA-192105 Synthesis of bile acids and bile salts 0.694505 0.158
R-HSA-5610787 Hedgehog 'off' state 0.697792 0.156
R-HSA-382556 ABC-family proteins mediated transport 0.697792 0.156
R-HSA-9860931 Response of endothelial cells to shear stress 0.710592 0.148
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 0.710592 0.148
R-HSA-111885 Opioid Signalling 0.710592 0.148
R-HSA-397014 Muscle contraction 0.713381 0.147
R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins 0.713706 0.146
R-HSA-9730414 MITF-M-regulated melanocyte development 0.715600 0.145
R-HSA-5696398 Nucleotide Excision Repair 0.716788 0.145
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 0.725836 0.139
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 0.725836 0.139
R-HSA-2672351 Stimuli-sensing channels 0.725836 0.139
R-HSA-199991 Membrane Trafficking 0.728179 0.138
R-HSA-194068 Bile acid and bile salt metabolism 0.731708 0.136
R-HSA-9855142 Cellular responses to mechanical stimuli 0.743078 0.129
R-HSA-9006925 Intracellular signaling by second messengers 0.748509 0.126
R-HSA-2871809 FCERI mediated Ca+2 mobilization 0.751291 0.124
R-HSA-4420097 VEGFA-VEGFR2 Pathway 0.751291 0.124
R-HSA-72737 Cap-dependent Translation Initiation 0.753970 0.123
R-HSA-72613 Eukaryotic Translation Initiation 0.753970 0.123
R-HSA-2219528 PI3K/AKT Signaling in Cancer 0.759243 0.120
R-HSA-9635486 Infection with Mycobacterium tuberculosis 0.766941 0.115
R-HSA-112316 Neuronal System 0.773153 0.112
R-HSA-6809371 Formation of the cornified envelope 0.774395 0.111
R-HSA-194138 Signaling by VEGF 0.779232 0.108
R-HSA-69206 G1/S Transition 0.779232 0.108
R-HSA-69481 G2/M Checkpoints 0.783966 0.106
R-HSA-187037 Signaling by NTRK1 (TRKA) 0.786295 0.104
R-HSA-1474165 Reproduction 0.793133 0.101
R-HSA-5576891 Cardiac conduction 0.795364 0.099
R-HSA-5688426 Deubiquitination 0.796524 0.099
R-HSA-8856688 Golgi-to-ER retrograde transport 0.797571 0.098
R-HSA-1474228 Degradation of the extracellular matrix 0.797571 0.098
R-HSA-388841 Regulation of T cell activation by CD28 family 0.798177 0.098
R-HSA-9734767 Developmental Cell Lineages 0.809422 0.092
R-HSA-9948299 Ribosome-associated quality control 0.812370 0.090
R-HSA-5358351 Signaling by Hedgehog 0.812370 0.090
R-HSA-1632852 Macroautophagy 0.818378 0.087
R-HSA-9018678 Biosynthesis of specialized proresolving mediators (SPMs) 0.824195 0.084
R-HSA-453279 Mitotic G1 phase and G1/S transition 0.829827 0.081
R-HSA-5663205 Infectious disease 0.831166 0.080
R-HSA-446728 Cell junction organization 0.831665 0.080
R-HSA-166520 Signaling by NTRKs 0.833482 0.079
R-HSA-8978868 Fatty acid metabolism 0.840871 0.075
R-HSA-9609507 Protein localization 0.842280 0.075
R-HSA-73887 Death Receptor Signaling 0.843984 0.074
R-HSA-5673001 RAF/MAP kinase cascade 0.846468 0.072
R-HSA-9612973 Autophagy 0.847336 0.072
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 0.850616 0.070
R-HSA-5684996 MAPK1/MAPK3 signaling 0.855266 0.068
R-HSA-5689880 Ub-specific processing proteases 0.874458 0.058
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 0.874458 0.058
R-HSA-9764265 Regulation of CDH1 Expression and Function 0.874458 0.058
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 0.877159 0.057
R-HSA-1500931 Cell-Cell communication 0.877938 0.057
R-HSA-5653656 Vesicle-mediated transport 0.884945 0.053
R-HSA-3781865 Diseases of glycosylation 0.888615 0.051
R-HSA-6798695 Neutrophil degranulation 0.889924 0.051
R-HSA-72163 mRNA Splicing - Major Pathway 0.900101 0.046
R-HSA-1428517 Aerobic respiration and respiratory electron transport 0.901688 0.045
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 0.902253 0.045
R-HSA-5683057 MAPK family signaling cascades 0.906712 0.043
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 0.909428 0.041
R-HSA-376176 Signaling by ROBO receptors 0.909428 0.041
R-HSA-72172 mRNA Splicing 0.911380 0.040
R-HSA-6805567 Keratinization 0.913291 0.039
R-HSA-9748784 Drug ADME 0.923922 0.034
R-HSA-418990 Adherens junctions interactions 0.923922 0.034
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors 0.933257 0.030
R-HSA-211859 Biological oxidations 0.933933 0.030
R-HSA-422475 Axon guidance 0.944568 0.025
R-HSA-421270 Cell-cell junction organization 0.946934 0.024
R-HSA-1280215 Cytokine Signaling in Immune system 0.953400 0.021
R-HSA-416476 G alpha (q) signalling events 0.953964 0.020
R-HSA-72766 Translation 0.955666 0.020
R-HSA-76002 Platelet activation, signaling and aggregation 0.958735 0.018
R-HSA-9675108 Nervous system development 0.958961 0.018
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.962194 0.017
R-HSA-449147 Signaling by Interleukins 0.971290 0.013
R-HSA-1474244 Extracellular matrix organization 0.977910 0.010
R-HSA-196854 Metabolism of vitamins and cofactors 0.984631 0.007
R-HSA-372790 Signaling by GPCR 0.986322 0.006
R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.987670 0.005
R-HSA-9824439 Bacterial Infection Pathways 0.988585 0.005
R-HSA-597592 Post-translational protein modification 0.988669 0.005
R-HSA-425407 SLC-mediated transmembrane transport 0.989433 0.005
R-HSA-418594 G alpha (i) signalling events 0.990537 0.004
R-HSA-168249 Innate Immune System 0.991777 0.004
R-HSA-388396 GPCR downstream signalling 0.992130 0.003
R-HSA-5668914 Diseases of metabolism 0.992412 0.003
R-HSA-71291 Metabolism of amino acids and derivatives 0.992606 0.003
R-HSA-109582 Hemostasis 0.992805 0.003
R-HSA-382551 Transport of small molecules 0.995147 0.002
R-HSA-392499 Metabolism of proteins 0.995700 0.002
R-HSA-1280218 Adaptive Immune System 0.997236 0.001
R-HSA-1430728 Metabolism 0.997501 0.001
R-HSA-500792 GPCR ligand binding 0.998745 0.001
R-HSA-168256 Immune System 0.999852 0.000
R-HSA-9709957 Sensory Perception 0.999999 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
CLK3CLK3 0.852 0.188 1 0.912
MARK4MARK4 0.850 0.458 4 0.683
QSKQSK 0.847 0.442 4 0.703
MARK3MARK3 0.845 0.527 4 0.755
NDR2NDR2 0.845 0.101 -3 0.858
AMPKA1AMPKA1 0.844 0.329 -3 0.877
MARK2MARK2 0.842 0.515 4 0.720
COTCOT 0.842 -0.006 2 0.860
NLKNLK 0.842 0.170 1 0.916
PIM3PIM3 0.841 0.088 -3 0.866
TSSK1TSSK1 0.841 0.309 -3 0.890
AMPKA2AMPKA2 0.841 0.296 -3 0.850
HIPK4HIPK4 0.840 0.193 1 0.866
SIKSIK 0.840 0.353 -3 0.806
PRKD2PRKD2 0.839 0.128 -3 0.809
NDR1NDR1 0.839 0.105 -3 0.858
RSK2RSK2 0.838 0.109 -3 0.823
NUAK2NUAK2 0.838 0.185 -3 0.878
CDC7CDC7 0.838 0.019 1 0.828
CAMK1BCAMK1B 0.838 0.132 -3 0.901
PRKD1PRKD1 0.837 0.096 -3 0.850
SRPK1SRPK1 0.837 0.145 -3 0.813
TSSK2TSSK2 0.835 0.242 -5 0.841
P90RSKP90RSK 0.834 0.093 -3 0.824
AURCAURC 0.834 0.122 -2 0.762
CDKL1CDKL1 0.834 0.096 -3 0.853
PIM1PIM1 0.833 0.108 -3 0.828
PKACGPKACG 0.833 0.124 -2 0.852
SRPK2SRPK2 0.833 0.141 -3 0.740
MOSMOS 0.832 0.017 1 0.874
SSTKSSTK 0.832 0.374 4 0.634
QIKQIK 0.832 0.287 -3 0.865
RSK3RSK3 0.832 0.098 -3 0.814
MARK1MARK1 0.832 0.431 4 0.715
LATS2LATS2 0.831 0.060 -5 0.788
CDKL5CDKL5 0.831 0.096 -3 0.845
RAF1RAF1 0.831 -0.002 1 0.842
BRSK1BRSK1 0.831 0.242 -3 0.828
ICKICK 0.831 0.126 -3 0.880
PRPKPRPK 0.831 -0.110 -1 0.854
BRSK2BRSK2 0.830 0.257 -3 0.844
MTORMTOR 0.830 -0.056 1 0.836
P70S6KBP70S6KB 0.829 0.095 -3 0.841
KISKIS 0.829 0.119 1 0.826
NUAK1NUAK1 0.829 0.200 -3 0.828
SKMLCKSKMLCK 0.829 0.099 -2 0.889
GCN2GCN2 0.829 -0.081 2 0.850
ERK5ERK5 0.829 0.066 1 0.857
TBK1TBK1 0.828 -0.021 1 0.756
CAMLCKCAMLCK 0.827 0.092 -2 0.903
IKKBIKKB 0.827 -0.086 -2 0.768
PRKD3PRKD3 0.827 0.118 -3 0.802
PKN3PKN3 0.827 0.033 -3 0.855
WNK1WNK1 0.827 0.058 -2 0.885
NIKNIK 0.827 0.073 -3 0.900
MST4MST4 0.826 0.032 2 0.835
PKCDPKCD 0.826 0.065 2 0.804
MELKMELK 0.826 0.174 -3 0.837
PKN2PKN2 0.826 0.054 -3 0.869
NIM1NIM1 0.826 0.121 3 0.783
CLK4CLK4 0.826 0.144 -3 0.824
DAPK2DAPK2 0.825 0.090 -3 0.899
RSK4RSK4 0.825 0.111 -3 0.789
PKACBPKACB 0.825 0.126 -2 0.789
ULK2ULK2 0.825 -0.093 2 0.823
AURBAURB 0.824 0.111 -2 0.756
ATRATR 0.824 -0.028 1 0.803
PRKXPRKX 0.824 0.142 -3 0.728
CLK1CLK1 0.823 0.155 -3 0.803
BMPR2BMPR2 0.823 -0.104 -2 0.889
PKG2PKG2 0.823 0.135 -2 0.805
CAMK2GCAMK2G 0.823 -0.074 2 0.835
IKKEIKKE 0.823 -0.056 1 0.749
CDK7CDK7 0.823 0.130 1 0.818
PDHK4PDHK4 0.823 -0.177 1 0.869
WNK3WNK3 0.822 0.020 1 0.823
CLK2CLK2 0.822 0.160 -3 0.804
HUNKHUNK 0.822 0.017 2 0.833
CHAK2CHAK2 0.822 -0.007 -1 0.883
SRPK3SRPK3 0.821 0.110 -3 0.787
DYRK2DYRK2 0.821 0.155 1 0.802
CDK8CDK8 0.821 0.117 1 0.814
TGFBR2TGFBR2 0.821 -0.018 -2 0.799
MAPKAPK3MAPKAPK3 0.820 0.035 -3 0.809
RIPK3RIPK3 0.820 -0.028 3 0.732
PAK3PAK3 0.820 0.053 -2 0.851
MSK1MSK1 0.819 0.084 -3 0.796
PAK1PAK1 0.819 0.051 -2 0.843
MSK2MSK2 0.819 0.052 -3 0.795
PDHK1PDHK1 0.819 -0.147 1 0.852
DSTYKDSTYK 0.819 -0.107 2 0.861
HIPK1HIPK1 0.819 0.183 1 0.820
CDK5CDK5 0.819 0.139 1 0.827
CAMK4CAMK4 0.819 0.051 -3 0.852
NEK6NEK6 0.818 -0.080 -2 0.850
MNK2MNK2 0.818 0.066 -2 0.868
LATS1LATS1 0.818 0.064 -3 0.864
NEK7NEK7 0.818 -0.092 -3 0.846
HIPK2HIPK2 0.818 0.171 1 0.739
AKT2AKT2 0.818 0.111 -3 0.754
MYLK4MYLK4 0.818 0.110 -2 0.846
GRK1GRK1 0.817 -0.023 -2 0.770
CAMK2DCAMK2D 0.817 -0.027 -3 0.866
CDK19CDK19 0.816 0.117 1 0.779
DYRK1ADYRK1A 0.816 0.159 1 0.858
MNK1MNK1 0.816 0.071 -2 0.886
SGK3SGK3 0.816 0.115 -3 0.802
JNK2JNK2 0.816 0.155 1 0.769
PIM2PIM2 0.816 0.107 -3 0.801
MLK1MLK1 0.815 -0.092 2 0.820
IKKAIKKA 0.815 -0.067 -2 0.745
MAPKAPK2MAPKAPK2 0.815 0.028 -3 0.770
IRE1IRE1 0.815 -0.026 1 0.777
CAMK2ACAMK2A 0.815 0.020 2 0.817
CAMK1GCAMK1G 0.815 0.134 -3 0.815
PAK6PAK6 0.814 0.060 -2 0.785
BCKDKBCKDK 0.814 -0.113 -1 0.815
CDK13CDK13 0.814 0.110 1 0.793
PHKG1PHKG1 0.814 0.023 -3 0.853
ULK1ULK1 0.813 -0.122 -3 0.819
GRK5GRK5 0.813 -0.161 -3 0.870
PAK2PAK2 0.813 0.051 -2 0.829
JNK3JNK3 0.813 0.143 1 0.797
CDK1CDK1 0.813 0.126 1 0.770
GRK6GRK6 0.812 -0.084 1 0.823
CDK18CDK18 0.812 0.120 1 0.749
CDK10CDK10 0.812 0.161 1 0.772
PKCBPKCB 0.812 0.024 2 0.749
PKACAPKACA 0.812 0.123 -2 0.753
MASTLMASTL 0.812 -0.147 -2 0.824
RIPK1RIPK1 0.811 -0.071 1 0.791
DCAMKL1DCAMKL1 0.811 0.091 -3 0.820
P38AP38A 0.811 0.141 1 0.827
SNRKSNRK 0.811 0.065 2 0.740
HIPK3HIPK3 0.811 0.150 1 0.827
NEK9NEK9 0.810 -0.104 2 0.852
CAMK2BCAMK2B 0.810 -0.018 2 0.785
PKCGPKCG 0.810 -0.002 2 0.752
DLKDLK 0.810 -0.137 1 0.832
MLK2MLK2 0.810 -0.096 2 0.837
CDK9CDK9 0.810 0.110 1 0.795
ERK2ERK2 0.810 0.128 1 0.805
ERK1ERK1 0.810 0.136 1 0.765
ANKRD3ANKRD3 0.810 -0.069 1 0.842
IRE2IRE2 0.810 0.001 2 0.783
DYRK1BDYRK1B 0.809 0.166 1 0.779
P38BP38B 0.809 0.150 1 0.767
AKT1AKT1 0.809 0.110 -3 0.763
P38GP38G 0.809 0.148 1 0.698
CDK14CDK14 0.808 0.139 1 0.786
GSK3BGSK3B 0.808 -0.028 4 0.258
CDK12CDK12 0.808 0.114 1 0.770
GSK3AGSK3A 0.808 0.004 4 0.263
PKCAPKCA 0.808 -0.004 2 0.741
CDK17CDK17 0.807 0.126 1 0.702
PKRPKR 0.807 -0.032 1 0.831
PKCHPKCH 0.807 0.004 2 0.745
DYRK3DYRK3 0.807 0.151 1 0.809
CHK1CHK1 0.807 0.047 -3 0.827
AURAAURA 0.806 0.046 -2 0.708
ALK4ALK4 0.806 -0.018 -2 0.839
CHAK1CHAK1 0.806 -0.046 2 0.808
PKCZPKCZ 0.806 -0.011 2 0.794
P70S6KP70S6K 0.806 0.076 -3 0.763
BMPR1BBMPR1B 0.805 0.032 1 0.772
MEK1MEK1 0.805 -0.054 2 0.858
VRK2VRK2 0.805 -0.045 1 0.880
DYRK4DYRK4 0.805 0.146 1 0.754
CAMK1DCAMK1D 0.804 0.114 -3 0.736
CDK2CDK2 0.804 0.083 1 0.823
MLK3MLK3 0.804 -0.084 2 0.757
PHKG2PHKG2 0.803 0.047 -3 0.840
NEK2NEK2 0.803 -0.038 2 0.829
PLK1PLK1 0.803 -0.084 -2 0.819
TGFBR1TGFBR1 0.802 -0.007 -2 0.810
CDK3CDK3 0.802 0.120 1 0.718
DCAMKL2DCAMKL2 0.802 0.059 -3 0.847
TTBK2TTBK2 0.802 -0.138 2 0.747
ATMATM 0.801 -0.060 1 0.725
AKT3AKT3 0.800 0.112 -3 0.692
CDK16CDK16 0.800 0.126 1 0.719
GRK4GRK4 0.800 -0.156 -2 0.798
MRCKAMRCKA 0.800 0.135 -3 0.797
PKCTPKCT 0.800 0.021 2 0.754
SMMLCKSMMLCK 0.799 0.062 -3 0.862
MRCKBMRCKB 0.799 0.130 -3 0.789
PRP4PRP4 0.799 0.054 -3 0.749
SMG1SMG1 0.798 -0.055 1 0.746
IRAK4IRAK4 0.798 -0.019 1 0.781
GRK7GRK7 0.798 -0.036 1 0.763
YSK4YSK4 0.798 -0.115 1 0.780
PINK1PINK1 0.798 -0.042 1 0.883
CAMK1ACAMK1A 0.797 0.144 -3 0.715
SGK1SGK1 0.797 0.115 -3 0.674
MAKMAK 0.797 0.155 -2 0.745
FAM20CFAM20C 0.797 -0.056 2 0.532
WNK4WNK4 0.796 -0.025 -2 0.864
MST3MST3 0.796 -0.011 2 0.831
ROCK2ROCK2 0.796 0.140 -3 0.823
PASKPASK 0.795 0.011 -3 0.880
MLK4MLK4 0.795 -0.115 2 0.752
ACVR2BACVR2B 0.795 -0.031 -2 0.801
P38DP38D 0.795 0.138 1 0.708
ACVR2AACVR2A 0.795 -0.037 -2 0.789
TLK2TLK2 0.795 -0.077 1 0.801
PAK5PAK5 0.795 0.042 -2 0.723
MPSK1MPSK1 0.795 0.033 1 0.810
ALK2ALK2 0.795 -0.034 -2 0.815
PLK4PLK4 0.795 -0.057 2 0.700
PLK3PLK3 0.795 -0.069 2 0.792
DAPK3DAPK3 0.795 0.087 -3 0.844
CK1ECK1E 0.794 0.004 -3 0.604
PKCIPKCI 0.794 0.016 2 0.757
MAPKAPK5MAPKAPK5 0.794 -0.041 -3 0.764
BRAFBRAF 0.794 -0.065 -4 0.842
MEK5MEK5 0.794 -0.130 2 0.849
PKCEPKCE 0.793 0.042 2 0.735
CDK4CDK4 0.793 0.127 1 0.758
CDK6CDK6 0.793 0.127 1 0.771
DNAPKDNAPK 0.792 -0.059 1 0.676
HRIHRI 0.792 -0.101 -2 0.852
PAK4PAK4 0.792 0.039 -2 0.724
PERKPERK 0.792 -0.104 -2 0.825
NEK5NEK5 0.791 -0.049 1 0.822
PKN1PKN1 0.791 0.050 -3 0.780
MEKK1MEKK1 0.791 -0.100 1 0.817
CHK2CHK2 0.791 0.072 -3 0.701
DRAK1DRAK1 0.791 -0.087 1 0.726
GAKGAK 0.790 0.039 1 0.844
MOKMOK 0.790 0.144 1 0.794
DMPK1DMPK1 0.790 0.157 -3 0.810
MEKK2MEKK2 0.790 -0.074 2 0.830
GRK2GRK2 0.790 -0.066 -2 0.704
TAO3TAO3 0.788 -0.059 1 0.807
ZAKZAK 0.788 -0.137 1 0.780
MEKK3MEKK3 0.788 -0.136 1 0.800
DAPK1DAPK1 0.788 0.065 -3 0.834
SBKSBK 0.788 0.094 -3 0.641
PKG1PKG1 0.788 0.119 -2 0.737
TLK1TLK1 0.787 -0.065 -2 0.816
BMPR1ABMPR1A 0.787 0.003 1 0.754
LKB1LKB1 0.787 -0.008 -3 0.826
JNK1JNK1 0.787 0.105 1 0.754
ERK7ERK7 0.787 0.038 2 0.538
CK1G1CK1G1 0.786 -0.020 -3 0.596
NEK8NEK8 0.785 -0.066 2 0.836
PDK1PDK1 0.785 -0.009 1 0.799
TAO2TAO2 0.784 -0.051 2 0.853
ROCK1ROCK1 0.784 0.135 -3 0.795
CRIKCRIK 0.784 0.128 -3 0.758
CK1DCK1D 0.784 0.004 -3 0.556
LOKLOK 0.784 0.019 -2 0.840
CK1A2CK1A2 0.783 0.009 -3 0.559
CAMKK1CAMKK1 0.782 -0.116 -2 0.793
NEK11NEK11 0.782 -0.116 1 0.801
MEKK6MEKK6 0.781 -0.045 1 0.810
GCKGCK 0.781 -0.020 1 0.818
CAMKK2CAMKK2 0.781 -0.070 -2 0.795
TAK1TAK1 0.780 -0.021 1 0.851
NEK4NEK4 0.780 -0.045 1 0.792
IRAK1IRAK1 0.780 -0.124 -1 0.763
HGKHGK 0.779 -0.032 3 0.855
BUB1BUB1 0.779 0.061 -5 0.775
PBKPBK 0.779 0.044 1 0.771
TTBK1TTBK1 0.779 -0.115 2 0.670
MAP3K15MAP3K15 0.778 -0.051 1 0.771
TNIKTNIK 0.778 -0.030 3 0.853
LRRK2LRRK2 0.778 -0.057 2 0.860
HPK1HPK1 0.778 -0.006 1 0.792
SLKSLK 0.776 -0.026 -2 0.766
MINKMINK 0.776 -0.056 1 0.803
NEK1NEK1 0.775 -0.028 1 0.796
KHS1KHS1 0.775 0.010 1 0.791
KHS2KHS2 0.774 0.018 1 0.806
EEF2KEEF2K 0.774 -0.069 3 0.834
MST2MST2 0.774 -0.082 1 0.812
GRK3GRK3 0.773 -0.078 -2 0.650
VRK1VRK1 0.772 -0.075 2 0.840
STK33STK33 0.771 -0.095 2 0.662
MEK2MEK2 0.769 -0.115 2 0.842
CK2A2CK2A2 0.769 -0.043 1 0.696
MST1MST1 0.769 -0.062 1 0.794
PDHK3_TYRPDHK3_TYR 0.769 0.134 4 0.497
YSK1YSK1 0.769 -0.063 2 0.819
RIPK2RIPK2 0.767 -0.135 1 0.737
PLK2PLK2 0.765 -0.074 -3 0.774
HASPINHASPIN 0.763 -0.003 -1 0.710
CK2A1CK2A1 0.762 -0.055 1 0.671
NEK3NEK3 0.761 -0.099 1 0.771
TESK1_TYRTESK1_TYR 0.760 0.018 3 0.864
TTKTTK 0.760 -0.047 -2 0.810
BIKEBIKE 0.760 0.012 1 0.721
PDHK4_TYRPDHK4_TYR 0.760 0.049 2 0.889
LIMK2_TYRLIMK2_TYR 0.759 0.067 -3 0.891
MAP2K4_TYRMAP2K4_TYR 0.756 -0.067 -1 0.864
OSR1OSR1 0.756 -0.094 2 0.815
MAP2K7_TYRMAP2K7_TYR 0.756 -0.023 2 0.881
YANK3YANK3 0.755 -0.051 2 0.431
ASK1ASK1 0.754 -0.075 1 0.758
MYO3BMYO3B 0.754 -0.065 2 0.836
MAP2K6_TYRMAP2K6_TYR 0.754 -0.072 -1 0.868
PKMYT1_TYRPKMYT1_TYR 0.754 -0.042 3 0.830
TAO1TAO1 0.753 -0.070 1 0.739
MYO3AMYO3A 0.751 -0.073 1 0.785
PINK1_TYRPINK1_TYR 0.751 -0.102 1 0.847
LIMK1_TYRLIMK1_TYR 0.750 -0.027 2 0.871
BMPR2_TYRBMPR2_TYR 0.749 -0.066 -1 0.854
PDHK1_TYRPDHK1_TYR 0.748 -0.088 -1 0.870
CK1ACK1A 0.747 -0.032 -3 0.466
AAK1AAK1 0.746 0.038 1 0.621
EPHA6EPHA6 0.746 -0.015 -1 0.853
RETRET 0.745 -0.077 1 0.805
ROS1ROS1 0.745 -0.041 3 0.763
DDR1DDR1 0.745 -0.052 4 0.448
TYRO3TYRO3 0.744 -0.052 3 0.779
ALPHAK3ALPHAK3 0.743 -0.114 -1 0.759
TYK2TYK2 0.742 -0.112 1 0.804
MST1RMST1R 0.741 -0.094 3 0.776
EPHB4EPHB4 0.741 -0.063 -1 0.840
TNNI3K_TYRTNNI3K_TYR 0.740 0.031 1 0.825
TXKTXK 0.740 0.012 1 0.821
JAK2JAK2 0.739 -0.107 1 0.809
STLK3STLK3 0.738 -0.126 1 0.751
YES1YES1 0.737 -0.052 -1 0.842
CSF1RCSF1R 0.737 -0.097 3 0.763
TNK1TNK1 0.736 -0.025 3 0.763
NEK10_TYRNEK10_TYR 0.736 -0.043 1 0.707
FGRFGR 0.736 -0.088 1 0.845
JAK3JAK3 0.735 -0.098 1 0.783
ABL2ABL2 0.734 -0.069 -1 0.796
TNK2TNK2 0.734 -0.078 3 0.717
INSRRINSRR 0.734 -0.096 3 0.720
FERFER 0.733 -0.121 1 0.857
DDR2DDR2 0.732 0.002 3 0.701
ABL1ABL1 0.732 -0.064 -1 0.788
PDGFRBPDGFRB 0.730 -0.121 3 0.784
LCKLCK 0.730 -0.044 -1 0.817
HCKHCK 0.730 -0.083 -1 0.819
KDRKDR 0.730 -0.075 3 0.724
FGFR2FGFR2 0.730 -0.109 3 0.755
TEKTEK 0.730 -0.063 3 0.709
EPHB1EPHB1 0.730 -0.096 1 0.819
BLKBLK 0.729 0.000 -1 0.819
FGFR1FGFR1 0.729 -0.070 3 0.730
EPHA4EPHA4 0.729 -0.085 2 0.775
ITKITK 0.729 -0.087 -1 0.798
JAK1JAK1 0.729 -0.068 1 0.748
AXLAXL 0.728 -0.094 3 0.736
EPHB3EPHB3 0.727 -0.096 -1 0.827
TECTEC 0.727 -0.055 -1 0.752
CK1G3CK1G3 0.726 -0.033 -3 0.421
FLT3FLT3 0.726 -0.130 3 0.775
EPHB2EPHB2 0.726 -0.085 -1 0.810
SRMSSRMS 0.726 -0.130 1 0.828
KITKIT 0.725 -0.135 3 0.762
BMXBMX 0.725 -0.060 -1 0.727
ALKALK 0.725 -0.093 3 0.696
MERTKMERTK 0.725 -0.095 3 0.733
BTKBTK 0.724 -0.119 -1 0.774
WEE1_TYRWEE1_TYR 0.723 -0.095 -1 0.755
LTKLTK 0.723 -0.094 3 0.713
PDGFRAPDGFRA 0.723 -0.163 3 0.781
METMET 0.722 -0.120 3 0.743
PTK6PTK6 0.720 -0.153 -1 0.730
YANK2YANK2 0.720 -0.074 2 0.440
EPHA1EPHA1 0.719 -0.093 3 0.718
FYNFYN 0.719 -0.051 -1 0.799
EPHA7EPHA7 0.718 -0.102 2 0.785
FGFR3FGFR3 0.717 -0.113 3 0.721
INSRINSR 0.717 -0.129 3 0.697
FLT1FLT1 0.717 -0.127 -1 0.804
FRKFRK 0.716 -0.093 -1 0.821
EPHA3EPHA3 0.716 -0.136 2 0.766
NTRK1NTRK1 0.715 -0.199 -1 0.816
NTRK2NTRK2 0.714 -0.165 3 0.714
PTK2BPTK2B 0.714 -0.074 -1 0.779
ERBB2ERBB2 0.714 -0.161 1 0.757
FLT4FLT4 0.713 -0.152 3 0.719
LYNLYN 0.713 -0.106 3 0.697
MATKMATK 0.709 -0.115 -1 0.711
SRCSRC 0.708 -0.098 -1 0.794
EPHA5EPHA5 0.708 -0.127 2 0.764
NTRK3NTRK3 0.707 -0.166 -1 0.769
EPHA8EPHA8 0.705 -0.120 -1 0.798
PTK2PTK2 0.704 -0.052 -1 0.781
CK1G2CK1G2 0.702 -0.058 -3 0.513
EGFREGFR 0.702 -0.124 1 0.667
CSKCSK 0.699 -0.173 2 0.798
FGFR4FGFR4 0.699 -0.135 -1 0.743
IGF1RIGF1R 0.698 -0.149 3 0.636
MUSKMUSK 0.698 -0.125 1 0.647
SYKSYK 0.698 -0.085 -1 0.750
EPHA2EPHA2 0.695 -0.132 -1 0.761
ERBB4ERBB4 0.690 -0.106 1 0.676
FESFES 0.684 -0.139 -1 0.701
ZAP70ZAP70 0.679 -0.080 -1 0.686