Motif 847 (n=84)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| C4P0D8 | TSNAX-DISC1 | S33 | ochoa | Disrupted in schizophrenia 1 isoform 51 (TSNAX-DISC1 readthrough (NMD candidate)) | None |
| F6TDL0 | P3R3URF-PIK3R3 | S232 | ochoa | Phosphatidylinositol 3-kinase regulatory subunit gamma (Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma) (p55PIK) | Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1. {ECO:0000256|ARBA:ARBA00057933}. |
| O15530 | PDPK1 | S241 | ochoa|psp | 3-phosphoinositide-dependent protein kinase 1 (hPDK1) (EC 2.7.11.1) | Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases (PubMed:10226025, PubMed:10480933, PubMed:10995762, PubMed:12167717, PubMed:14585963, PubMed:14604990, PubMed:16207722, PubMed:16251192, PubMed:17327236, PubMed:17371830, PubMed:18835241, PubMed:9094314, PubMed:9368760, PubMed:9445476, PubMed:9445477, PubMed:9707564, PubMed:9768361). Its targets include: protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), p70 ribosomal protein S6 kinase (RPS6KB1), p90 ribosomal protein S6 kinase (RPS6KA1, RPS6KA2 and RPS6KA3), cyclic AMP-dependent protein kinase (PRKACA), protein kinase C (PRKCD and PRKCZ), serum and glucocorticoid-inducible kinase (SGK1, SGK2 and SGK3), p21-activated kinase-1 (PAK1), TSSK3, protein kinase PKN (PKN1 and PKN2) (PubMed:10226025, PubMed:10480933, PubMed:10995762, PubMed:12167717, PubMed:14585963, PubMed:14604990, PubMed:16207722, PubMed:16251192, PubMed:17327236, PubMed:17371830, PubMed:18835241, PubMed:9094314, PubMed:9368760, PubMed:9445476, PubMed:9707564, PubMed:9768361). Plays a central role in the transduction of signals from insulin by providing the activating phosphorylation to PKB/AKT1, thus propagating the signal to downstream targets controlling cell proliferation and survival, as well as glucose and amino acid uptake and storage (PubMed:10226025, PubMed:12167717, PubMed:9094314). Negatively regulates the TGF-beta-induced signaling by: modulating the association of SMAD3 and SMAD7 with TGF-beta receptor, phosphorylating SMAD2, SMAD3, SMAD4 and SMAD7, preventing the nuclear translocation of SMAD3 and SMAD4 and the translocation of SMAD7 from the nucleus to the cytoplasm in response to TGF-beta (PubMed:17327236). Activates PPARG transcriptional activity and promotes adipocyte differentiation (By similarity). Activates the NF-kappa-B pathway via phosphorylation of IKKB (PubMed:16207722). The tyrosine phosphorylated form is crucial for the regulation of focal adhesions by angiotensin II (PubMed:14585963). Controls proliferation, survival, and growth of developing pancreatic cells (By similarity). Participates in the regulation of Ca(2+) entry and Ca(2+)-activated K(+) channels of mast cells (By similarity). Essential for the motility of vascular endothelial cells (ECs) and is involved in the regulation of their chemotaxis (PubMed:17371830). Plays a critical role in cardiac homeostasis by serving as a dual effector for cell survival and beta-adrenergic response (By similarity). Plays an important role during thymocyte development by regulating the expression of key nutrient receptors on the surface of pre-T cells and mediating Notch-induced cell growth and proliferative responses (By similarity). Provides negative feedback inhibition to toll-like receptor-mediated NF-kappa-B activation in macrophages (By similarity). {ECO:0000250|UniProtKB:Q9Z2A0, ECO:0000269|PubMed:10226025, ECO:0000269|PubMed:10480933, ECO:0000269|PubMed:10995762, ECO:0000269|PubMed:12167717, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:14604990, ECO:0000269|PubMed:16207722, ECO:0000269|PubMed:16251192, ECO:0000269|PubMed:17327236, ECO:0000269|PubMed:17371830, ECO:0000269|PubMed:18835241, ECO:0000269|PubMed:9094314, ECO:0000269|PubMed:9368760, ECO:0000269|PubMed:9445476, ECO:0000269|PubMed:9445477, ECO:0000269|PubMed:9707564, ECO:0000269|PubMed:9768361}.; FUNCTION: [Isoform 3]: Catalytically inactive. {ECO:0000269|PubMed:9445477}. |
| O43715 | TRIAP1 | S33 | ochoa | TP53-regulated inhibitor of apoptosis 1 (Protein 15E1.1) (WF-1) (p53-inducible cell-survival factor) (p53CSV) | Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane (PubMed:23931759). Likewise, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes (in vitro) and probably functions as a PA transporter across the mitochondrion intermembrane space (in vivo) (PubMed:26071602). Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis (PubMed:15735003). {ECO:0000269|PubMed:15735003, ECO:0000269|PubMed:23931759, ECO:0000269|PubMed:26071602}. |
| O75179 | ANKRD17 | S156 | ochoa | Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) | Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity). {ECO:0000250|UniProtKB:Q99NH0, ECO:0000269|PubMed:17276651, ECO:0000269|PubMed:19150984, ECO:0000269|PubMed:22328336, ECO:0000269|PubMed:23711367}. |
| O75569 | PRKRA | S232 | ochoa | Interferon-inducible double-stranded RNA-dependent protein kinase activator A (PKR-associated protein X) (PKR-associating protein X) (Protein activator of the interferon-induced protein kinase) (Protein kinase, interferon-inducible double-stranded RNA-dependent activator) | Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity). {ECO:0000250, ECO:0000269|PubMed:10336432, ECO:0000269|PubMed:11238927, ECO:0000269|PubMed:16424907, ECO:0000269|PubMed:16982605, ECO:0000269|PubMed:17452327, ECO:0000269|PubMed:9687506}. |
| O94885 | SASH1 | S387 | ochoa | SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) | Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). {ECO:0000269|PubMed:23333244, ECO:0000269|PubMed:23776175, ECO:0000269|PubMed:25315659}. |
| O95359 | TACC2 | S2534 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| O95425 | SVIL | S1052 | ochoa | Supervillin (Archvillin) (p205/p250) | [Isoform 1]: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699). Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (PubMed:19109420). {ECO:0000269|PubMed:12711699, ECO:0000269|PubMed:19109420}.; FUNCTION: [Isoform 2]: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity). {ECO:0000250|UniProtKB:O46385}. |
| P04035 | HMGCR | S508 | ochoa | 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) (EC 1.1.1.34) | Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis (PubMed:21357570, PubMed:2991281, PubMed:36745799, PubMed:6995544). HMGCR is the main target of statins, a class of cholesterol-lowering drugs (PubMed:11349148, PubMed:18540668, PubMed:36745799). {ECO:0000269|PubMed:11349148, ECO:0000269|PubMed:18540668, ECO:0000269|PubMed:21357570, ECO:0000269|PubMed:2991281, ECO:0000269|PubMed:36745799, ECO:0000269|PubMed:6995544}. |
| P11055 | MYH3 | S1477 | ochoa | Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE) | Muscle contraction. |
| P11137 | MAP2 | S1021 | ochoa | Microtubule-associated protein 2 (MAP-2) | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
| P11171 | EPB41 | S144 | ochoa | Protein 4.1 (P4.1) (4.1R) (Band 4.1) (EPB4.1) (Erythrocyte membrane protein band 4.1) | Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| P12882 | MYH1 | S1480 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12883 | MYH7 | S1476 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P13533 | MYH6 | S1478 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P13535 | MYH8 | S1479 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
| P13639 | EEF2 | S623 | ochoa | Elongation factor 2 (EF-2) (EC 3.6.5.-) | Catalyzes the GTP-dependent ribosomal translocation step during translation elongation (PubMed:26593721). During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively (PubMed:26593721). Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (PubMed:26593721). {ECO:0000269|PubMed:26593721}. |
| P17661 | DES | S301 | ochoa | Desmin | Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity (PubMed:25358400). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed:24200904, PubMed:25394388, PubMed:26724190). May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Required for nuclear membrane integrity, via anchoring at the cell tip and nuclear envelope, resulting in maintenance of microtubule-derived intracellular mechanical forces (By similarity). Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin (By similarity). {ECO:0000250|UniProtKB:P31001, ECO:0000269|PubMed:24200904, ECO:0000269|PubMed:25394388, ECO:0000269|PubMed:26724190, ECO:0000303|PubMed:25358400}. |
| P27815 | PDE4A | S346 | ochoa | 3',5'-cyclic-AMP phosphodiesterase 4A (EC 3.1.4.53) (DPDE2) (PDE46) (cAMP-specific phosphodiesterase 4A) | Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:11566027, ECO:0000269|PubMed:2160582}.; FUNCTION: [Isoform 1]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310}.; FUNCTION: [Isoform 2]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:15738310}.; FUNCTION: [Isoform 3]: Efficiently hydrolyzes cAMP. The phosphodiesterase activity is not affected by calcium, calmodulin or cyclic GMP (cGMP) levels. Does not hydrolyze cGMP. {ECO:0000269|PubMed:7888306}.; FUNCTION: [Isoform 4]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:9677330}.; FUNCTION: [Isoform 6]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310, ECO:0000269|PubMed:17727341}.; FUNCTION: [Isoform 7]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:18095939}. |
| P33241 | LSP1 | S218 | ochoa | Lymphocyte-specific protein 1 (47 kDa actin-binding protein) (52 kDa phosphoprotein) (pp52) (Lymphocyte-specific antigen WP34) | May play a role in mediating neutrophil activation and chemotaxis. {ECO:0000250}. |
| P38646 | HSPA9 | S639 | ochoa | Stress-70 protein, mitochondrial (EC 3.6.4.10) (75 kDa glucose-regulated protein) (GRP-75) (Heat shock 70 kDa protein 9) (Heat shock protein family A member 9) (Mortalin) (MOT) (Peptide-binding protein 74) (PBP74) | Mitochondrial chaperone that plays a key role in mitochondrial protein import, folding, and assembly. Plays an essential role in the protein quality control system, the correct folding of proteins, the re-folding of misfolded proteins, and the targeting of proteins for subsequent degradation. These processes are achieved through cycles of ATP binding, ATP hydrolysis, and ADP release, mediated by co-chaperones (PubMed:18632665, PubMed:25615450, PubMed:28848044, PubMed:30933555, PubMed:31177526). In mitochondria, it associates with the TIM (translocase of the inner membrane) protein complex to assist in the import and folding of mitochondrial proteins (By similarity). Plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis, interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU (PubMed:26702583). Regulates erythropoiesis via stabilization of ISC assembly (PubMed:21123823, PubMed:26702583). Regulates mitochondrial calcium-dependent apoptosis by coupling two calcium channels, ITPR1 and VDAC1, at the mitochondria-associated endoplasmic reticulum (ER) membrane to facilitate calcium transport from the ER lumen to the mitochondria intermembrane space, providing calcium for the downstream calcium channel MCU, which releases it into the mitochondrial matrix (By similarity). Although primarily located in the mitochondria, it is also found in other cellular compartments. In the cytosol, it associates with proteins involved in signaling, apoptosis, or senescence. It may play a role in cell cycle regulation via its interaction with and promotion of degradation of TP53 (PubMed:24625977, PubMed:26634371). May play a role in the control of cell proliferation and cellular aging (By similarity). Protects against reactive oxygen species (ROS) (By similarity). Extracellular HSPA9 plays a cytoprotective role by preventing cell lysis following immune attack by the membrane attack complex by disrupting formation of the complex (PubMed:16091382). {ECO:0000250|UniProtKB:P0CS90, ECO:0000250|UniProtKB:P38647, ECO:0000269|PubMed:16091382, ECO:0000269|PubMed:18632665, ECO:0000269|PubMed:21123823, ECO:0000269|PubMed:24625977, ECO:0000269|PubMed:25615450, ECO:0000269|PubMed:26634371, ECO:0000269|PubMed:26702583, ECO:0000269|PubMed:28848044, ECO:0000269|PubMed:30933555, ECO:0000269|PubMed:31177526}. |
| P49792 | RANBP2 | S3053 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P54760 | EPHB4 | Y581 | ochoa | Ephrin type-B receptor 4 (EC 2.7.10.1) (Hepatoma transmembrane kinase) (Tyrosine-protein kinase TYRO11) | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. {ECO:0000269|PubMed:12734395, ECO:0000269|PubMed:16424904, ECO:0000269|PubMed:27400125, ECO:0000269|PubMed:30578106}. |
| P54920 | NAPA | S26 | ochoa | Alpha-soluble NSF attachment protein (SNAP-alpha) (N-ethylmaleimide-sensitive factor attachment protein alpha) | Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus (Probable). Together with GNA12 promotes CDH5 localization to plasma membrane (PubMed:15980433). {ECO:0000269|PubMed:15980433, ECO:0000305}. |
| P55081 | MFAP1 | S361 | ochoa | Microfibrillar-associated protein 1 (Spliceosome B complex protein MFAP1) | Involved in pre-mRNA splicing as a component of the spliceosome. {ECO:0000269|PubMed:28781166}. |
| P78527 | PRKDC | S2998 | ochoa | DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) | Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250|UniProtKB:P97313, ECO:0000269|PubMed:10026262, ECO:0000269|PubMed:10467406, ECO:0000269|PubMed:11889123, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12509254, ECO:0000269|PubMed:12649176, ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:14612514, ECO:0000269|PubMed:14627815, ECO:0000269|PubMed:14704337, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:15262962, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:1597196, ECO:0000269|PubMed:16046194, ECO:0000269|PubMed:16397295, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:2247066, ECO:0000269|PubMed:2507541, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30247612, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33854234, ECO:0000269|PubMed:34352203, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:8407951, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9362500, ECO:0000269|PubMed:9363941, ECO:0000269|PubMed:9679063}. |
| Q03001 | DST | S3920 | ochoa | Dystonin (230 kDa bullous pemphigoid antigen) (230/240 kDa bullous pemphigoid antigen) (Bullous pemphigoid antigen 1) (BPA) (Bullous pemphigoid antigen) (Dystonia musculorum protein) (Hemidesmosomal plaque protein) | Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1 (By similarity). {ECO:0000250|UniProtKB:Q91ZU6}.; FUNCTION: [Isoform 3]: Plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity.; FUNCTION: [Isoform 6]: Required for bundling actin filaments around the nucleus. {ECO:0000250, ECO:0000269|PubMed:10428034, ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692}.; FUNCTION: [Isoform 7]: Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. |
| Q07343 | PDE4B | S319 | ochoa | 3',5'-cyclic-AMP phosphodiesterase 4B (EC 3.1.4.53) (DPDE4) (PDE32) (cAMP-specific phosphodiesterase 4B) | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:15260978). May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents. {ECO:0000269|PubMed:10846163, ECO:0000269|PubMed:15003452, ECO:0000269|PubMed:15260978}. |
| Q08499 | PDE4D | S375 | ochoa | 3',5'-cyclic-AMP phosphodiesterase 4D (EC 3.1.4.53) (DPDE3) (PDE43) (cAMP-specific phosphodiesterase 4D) | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:9371713}. |
| Q0ZGT2 | NEXN | S442 | ochoa | Nexilin (F-actin-binding protein) (Nelin) | Involved in regulating cell migration through association with the actin cytoskeleton. Has an essential role in the maintenance of Z line and sarcomere integrity. {ECO:0000269|PubMed:12053183, ECO:0000269|PubMed:15823560, ECO:0000269|PubMed:19881492}. |
| Q13061 | TRDN | S642 | ochoa | Triadin | Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction. Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact (By similarity). Required for normal skeletal muscle strength. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. {ECO:0000250|UniProtKB:E9Q9K5, ECO:0000269|PubMed:22422768}. |
| Q13426 | XRCC4 | S315 | ochoa | DNA repair protein XRCC4 (hXRCC4) (X-ray repair cross-complementing protein 4) [Cleaved into: Protein XRCC4, C-terminus (XRCC4/C)] | [DNA repair protein XRCC4]: DNA non-homologous end joining (NHEJ) core factor, required for double-strand break repair and V(D)J recombination (PubMed:10757784, PubMed:10854421, PubMed:12517771, PubMed:16412978, PubMed:17124166, PubMed:17290226, PubMed:22228831, PubMed:25597996, PubMed:25742519, PubMed:25934149, PubMed:26100018, PubMed:26774286, PubMed:8548796). Acts as a scaffold protein that regulates recruitment of other proteins to DNA double-strand breaks (DSBs) (PubMed:15385968, PubMed:20852255, PubMed:26774286, PubMed:27437582). Associates with NHEJ1/XLF to form alternating helical filaments that bridge DNA and act like a bandage, holding together the broken DNA until it is repaired (PubMed:21768349, PubMed:21775435, PubMed:22287571, PubMed:26100018, PubMed:27437582, PubMed:28500754). The XRCC4-NHEJ1/XLF subcomplex binds to the DNA fragments of a DSB in a highly diffusive manner and robustly bridges two independent DNA molecules, holding the broken DNA fragments in close proximity to one other (PubMed:27437582). The mobility of the bridges ensures that the ends remain accessible for further processing by other repair factors (PubMed:27437582). Plays a key role in the NHEJ ligation step of the broken DNA during DSB repair via direct interaction with DNA ligase IV (LIG4): the LIG4-XRCC4 subcomplex reseals the DNA breaks after the gap filling is completed (PubMed:10757784, PubMed:10854421, PubMed:12517771, PubMed:17290226, PubMed:19837014, PubMed:9242410). XRCC4 stabilizes LIG4, regulates its subcellular localization and enhances LIG4's joining activity (PubMed:10757784, PubMed:10854421, PubMed:12517771, PubMed:17290226, PubMed:21982441, PubMed:22228831, PubMed:9242410). Binding of the LIG4-XRCC4 subcomplex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends (PubMed:10757784, PubMed:10854421). Promotes displacement of PNKP from processed strand break termini (PubMed:20852255, PubMed:28453785). {ECO:0000269|PubMed:10757784, ECO:0000269|PubMed:10854421, ECO:0000269|PubMed:12517771, ECO:0000269|PubMed:15385968, ECO:0000269|PubMed:16412978, ECO:0000269|PubMed:17124166, ECO:0000269|PubMed:17290226, ECO:0000269|PubMed:19837014, ECO:0000269|PubMed:20852255, ECO:0000269|PubMed:21768349, ECO:0000269|PubMed:21775435, ECO:0000269|PubMed:21982441, ECO:0000269|PubMed:22228831, ECO:0000269|PubMed:22287571, ECO:0000269|PubMed:25597996, ECO:0000269|PubMed:25742519, ECO:0000269|PubMed:25934149, ECO:0000269|PubMed:26100018, ECO:0000269|PubMed:26774286, ECO:0000269|PubMed:27437582, ECO:0000269|PubMed:28453785, ECO:0000269|PubMed:28500754, ECO:0000269|PubMed:8548796, ECO:0000269|PubMed:9242410}.; FUNCTION: [Protein XRCC4, C-terminus]: Acts as an activator of the phospholipid scramblase activity of XKR4 (PubMed:33725486). This form, which is generated upon caspase-3 (CASP3) cleavage, translocates into the cytoplasm and interacts with XKR4, thereby promoting phosphatidylserine scramblase activity of XKR4 and leading to phosphatidylserine exposure on apoptotic cell surface (PubMed:33725486). {ECO:0000269|PubMed:33725486}. |
| Q14004 | CDK13 | S291 | ochoa | Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) | Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}. |
| Q14008 | CKAP5 | S247 | ochoa | Cytoskeleton-associated protein 5 (Colonic and hepatic tumor overexpressed gene protein) (Ch-TOG) | Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as a processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments (PubMed:27156448). {ECO:0000269|PubMed:12569123, ECO:0000269|PubMed:18809577, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:21646404, ECO:0000269|PubMed:23532825, ECO:0000269|PubMed:27156448, ECO:0000269|PubMed:9570755}. |
| Q14112 | NID2 | S370 | ochoa | Nidogen-2 (NID-2) (Osteonidogen) | Cell adhesion glycoprotein which is widely distributed in basement membranes. Binds to collagens I and IV, to perlecan and to laminin 1. Does not bind fibulins. It probably has a role in cell-extracellular matrix interactions. |
| Q14160 | SCRIB | S23 | ochoa | Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) | Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}. |
| Q14203 | DCTN1 | S320 | ochoa | Dynactin subunit 1 (150 kDa dynein-associated polypeptide) (DAP-150) (DP-150) (p135) (p150-glued) | Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule (PubMed:25185702). Can regulate microtubule stability by promoting microtubule formation, nucleation and polymerization and by inhibiting microtubule catastrophe in neurons. Inhibits microtubule catastrophe by binding both to microtubules and to tubulin, leading to enhanced microtubule stability along the axon (PubMed:23874158). Plays a role in metaphase spindle orientation (PubMed:22327364). Plays a role in centriole cohesion and subdistal appendage organization and function. Its recruitment to the centriole in a KIF3A-dependent manner is essential for the maintenance of centriole cohesion and the formation of subdistal appendage. Also required for microtubule anchoring at the mother centriole (PubMed:23386061). Plays a role in primary cilia formation (PubMed:25774020). {ECO:0000250|UniProtKB:A0A287B8J2, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23386061, ECO:0000269|PubMed:23874158, ECO:0000269|PubMed:25185702, ECO:0000269|PubMed:25774020}. |
| Q14980 | NUMA1 | S1229 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q15545 | TAF7 | S171 | ochoa | Transcription initiation factor TFIID subunit 7 (RNA polymerase II TBP-associated factor subunit F) (Transcription initiation factor TFIID 55 kDa subunit) (TAF(II)55) (TAFII-55) (TAFII55) | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:10438527, PubMed:33795473). TAF7 forms a promoter DNA binding subcomplex of TFIID, together with TAF1 and TAF2 (PubMed:33795473). Part of a TFIID complex containing TAF10 (TFIID alpha) and a TFIID complex lacking TAF10 (TFIID beta) (PubMed:10438527). {ECO:0000269|PubMed:10438527, ECO:0000269|PubMed:33795473}. |
| Q15545 | TAF7 | S201 | ochoa | Transcription initiation factor TFIID subunit 7 (RNA polymerase II TBP-associated factor subunit F) (Transcription initiation factor TFIID 55 kDa subunit) (TAF(II)55) (TAFII-55) (TAFII55) | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:10438527, PubMed:33795473). TAF7 forms a promoter DNA binding subcomplex of TFIID, together with TAF1 and TAF2 (PubMed:33795473). Part of a TFIID complex containing TAF10 (TFIID alpha) and a TFIID complex lacking TAF10 (TFIID beta) (PubMed:10438527). {ECO:0000269|PubMed:10438527, ECO:0000269|PubMed:33795473}. |
| Q16851 | UGP2 | S45 | ochoa | UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) (UDP-glucose pyrophosphorylase) (UDPGP) (UGPase) | UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen. {ECO:0000269|PubMed:31820119, ECO:0000269|PubMed:8354390, ECO:0000269|PubMed:8631325}. |
| Q5QJE6 | DNTTIP2 | S429 | ochoa | Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) | Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}. |
| Q5VT06 | CEP350 | S2443 | ochoa | Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) | Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CPAP (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}. |
| Q6A1A2 | PDPK2P | S214 | ochoa | Putative 3-phosphoinositide-dependent protein kinase 2 (EC 2.7.11.1) (3-phosphoinositide-dependent protein kinase 2 pseudogene) | Phosphorylates and activates not only PKB/AKT, but also PKA, PKC-zeta, RPS6KA1 and RPS6KB1. May play a general role in signaling processes and in development (By similarity). {ECO:0000250}. |
| Q7Z2Z1 | TICRR | S1595 | ochoa | Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) | Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}. |
| Q7Z417 | NUFIP2 | S113 | ochoa | FMR1-interacting protein NUFIP2 (82 kDa FMRP-interacting protein) (82-FIP) (Cell proliferation-inducing gene 1 protein) (FMRP-interacting protein 2) (Nuclear FMR1-interacting protein 2) | Binds RNA. {ECO:0000269|PubMed:12837692}. |
| Q86SU0 | ILDR1 | S514 | ochoa | Immunoglobulin-like domain-containing receptor 1 (Angulin-2) | Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (tTJs) (PubMed:23239027). Crucial for normal hearing by maintaining the structural and functional integrity of tTJs, which are critical for the survival of auditory neurosensory HCs. Mediates fatty acids and lipoproteins-stimulated CCK/cholecystokinin secretion in the small intestine. In the inner ear, may regulate alternative pre-mRNA splicing via binding to TRA2A, TRA2B and SRSF1 (By similarity). {ECO:0000250|UniProtKB:Q8CBR1, ECO:0000269|PubMed:23239027}.; FUNCTION: (Microbial infection) Promotes influenza virus infection by inhibiting viral nucleoprotein NP binding to PLSCR1 and thereby PLSCR1-mediated antiviral activity. {ECO:0000269|PubMed:35595813}. |
| Q8IWB9 | TEX2 | S389 | ochoa | Testis-expressed protein 2 (Transmembrane protein 96) | During endoplasmic reticulum (ER) stress or when cellular ceramide levels increase, may induce contacts between the ER and medial-Golgi complex to facilitate non-vesicular transport of ceramides from the ER to the Golgi complex where they are converted to complex sphingolipids, preventing toxic ceramide accumulation. {ECO:0000269|PubMed:28011845}. |
| Q8IY18 | SMC5 | S636 | ochoa | Structural maintenance of chromosomes protein 5 (SMC protein 5) (SMC-5) (hSMC5) | Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541). {ECO:0000269|PubMed:16810316, ECO:0000269|PubMed:17589526, ECO:0000269|PubMed:19502785, ECO:0000269|PubMed:26983541}. |
| Q8WXX7 | AUTS2 | S853 | ochoa | Autism susceptibility gene 2 protein | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:25519132). The PRC1-like complex that contains PCGF5, RNF2, CSNK2B, RYBP and AUTS2 has decreased histone H2A ubiquitination activity, due to the phosphorylation of RNF2 by CSNK2B (PubMed:25519132). As a consequence, the complex mediates transcriptional activation (PubMed:25519132). In the cytoplasm, plays a role in axon and dendrite elongation and in neuronal migration during embryonic brain development. Promotes reorganization of the actin cytoskeleton, lamellipodia formation and neurite elongation via its interaction with RAC guanine nucleotide exchange factors, which then leads to the activation of RAC1 (By similarity). {ECO:0000250|UniProtKB:A0A087WPF7, ECO:0000269|PubMed:25519132}. |
| Q92547 | TOPBP1 | S747 | ochoa | DNA topoisomerase 2-binding protein 1 (DNA topoisomerase II-beta-binding protein 1) (TopBP1) (DNA topoisomerase II-binding protein 1) | Scaffold protein that acts as a key protein-protein adapter in DNA replication and DNA repair (PubMed:10498869, PubMed:11395493, PubMed:11714696, PubMed:17575048, PubMed:20545769, PubMed:21777809, PubMed:26811421, PubMed:30898438, PubMed:31135337, PubMed:33592542, PubMed:35597237, PubMed:37674080). Composed of multiple BRCT domains, which specifically recognize and bind phosphorylated proteins, bringing proteins together into functional combinations (PubMed:17575048, PubMed:20545769, PubMed:21777809, PubMed:26811421, PubMed:30898438, PubMed:31135337, PubMed:35597237, PubMed:37674080). Required for DNA replication initiation but not for the formation of pre-replicative complexes or the elongation stages (By similarity). Necessary for the loading of replication factors onto chromatin, including GMNC, CDC45, DNA polymerases and components of the GINS complex (By similarity). Plays a central role in DNA repair by bridging proteins and promoting recruitment of proteins to DNA damage sites (PubMed:30898438, PubMed:35597237, PubMed:37674080). Involved in double-strand break (DSB) repair via homologous recombination in S-phase by promoting the exchange between the DNA replication factor A (RPA) complex and RAD51 (PubMed:26811421, PubMed:35597237). Mechanistically, TOPBP1 is recruited to DNA damage sites in S-phase via interaction with phosphorylated HTATSF1, and promotes the loading of RAD51, thereby facilitating RAD51 nucleofilaments formation and RPA displacement, followed by homologous recombination (PubMed:35597237). Involved in microhomology-mediated end-joining (MMEJ) DNA repair by promoting recruitment of polymerase theta (POLQ) to DNA damage sites during mitosis (PubMed:37674080). MMEJ is an alternative non-homologous end-joining (NHEJ) machinery that takes place during mitosis to repair DSBs in DNA that originate in S-phase (PubMed:37674080). Recognizes and binds POLQ phosphorylated by PLK1, enabling its recruitment to DSBs for subsequent repair (PubMed:37674080). Involved in G1 DNA damage checkpoint by acting as a molecular adapter that couples TP53BP1 and the 9-1-1 complex (PubMed:31135337). In response to DNA damage, triggers the recruitment of checkpoint signaling proteins on chromatin, which activate the CHEK1 signaling pathway and block S-phase progression (PubMed:16530042, PubMed:21777809). Acts as an activator of the kinase activity of ATR (PubMed:16530042, PubMed:21777809). Also required for chromosomal stability when DSBs occur during mitosis by forming filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Together with CIP2A, plays an essential role in the response to genome instability generated by the presence of acentric chromosome fragments derived from shattered chromosomes within micronuclei (PubMed:35121901, PubMed:35842428, PubMed:37165191, PubMed:37316668). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, the CIP2A-TOPBP1 complex tethers chromosome fragments during mitosis to ensure clustered segregation of the fragments to a single daughter cell nucleus, facilitating re-ligation with limited chromosome scattering and loss (PubMed:37165191, PubMed:37316668). Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters, thereby down-regulating E2F1 activity and inhibiting E2F1-dependent apoptosis during G1/S transition and after DNA damage (PubMed:12697828, PubMed:15075294). {ECO:0000250|UniProtKB:Q800K6, ECO:0000269|PubMed:10498869, ECO:0000269|PubMed:11395493, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:12697828, ECO:0000269|PubMed:15075294, ECO:0000269|PubMed:16530042, ECO:0000269|PubMed:17575048, ECO:0000269|PubMed:20545769, ECO:0000269|PubMed:21777809, ECO:0000269|PubMed:26811421, ECO:0000269|PubMed:30898438, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:33592542, ECO:0000269|PubMed:35121901, ECO:0000269|PubMed:35597237, ECO:0000269|PubMed:35842428, ECO:0000269|PubMed:37165191, ECO:0000269|PubMed:37316668, ECO:0000269|PubMed:37674080}. |
| Q92551 | IP6K1 | S184 | ochoa | Inositol hexakisphosphate kinase 1 (InsP6 kinase 1) (EC 2.7.4.21) (Inositol hexaphosphate kinase 1) | Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. |
| Q92569 | PIK3R3 | S186 | ochoa | Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase regulatory subunit gamma) (PI3K regulatory subunit gamma) (PtdIns-3-kinase regulatory subunit gamma) (Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma) (PI3-kinase subunit p55-gamma) (PtdIns-3-kinase regulatory subunit p55-gamma) (p55PIK) | Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1. |
| Q96BX8 | MOB3A | S38 | psp | MOB kinase activator 3A (MOB-LAK) (Mob1 homolog 2A) (Mps one binder kinase activator-like 2A) | May regulate the activity of kinases. {ECO:0000250}. |
| Q96PC5 | MIA2 | S734 | ochoa | Melanoma inhibitory activity protein 2 (MIA protein 2) (CTAGE family member 5 ER export factor) (Cutaneous T-cell lymphoma-associated antigen 5) (Meningioma-expressed antigen 6/11) | Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum (PubMed:21525241, PubMed:25202031, PubMed:27138255, PubMed:27170179). Plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum (PubMed:27138255). Thereby, may play a role in cholesterol and triglyceride homeostasis (By similarity). Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites (PubMed:21525241, PubMed:25202031, PubMed:27170179). {ECO:0000250|UniProtKB:Q91ZV0, ECO:0000269|PubMed:21525241, ECO:0000269|PubMed:25202031, ECO:0000269|PubMed:27138255, ECO:0000269|PubMed:27170179}. |
| Q96QT4 | TRPM7 | S1477 | ochoa|psp | Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form] | Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644). {ECO:0000250|UniProtKB:Q923J1, ECO:0000269|PubMed:11385574, ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:18365021, ECO:0000269|PubMed:18394644, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:35561741, ECO:0000269|PubMed:36027648}.; FUNCTION: [TRPM7 channel, cleaved form]: The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling. {ECO:0000250|UniProtKB:Q923J1}.; FUNCTION: [TRPM7 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development. {ECO:0000250|UniProtKB:Q923J1}. |
| Q96RT6 | CTAGE1 | S96 | ochoa | cTAGE family member 2 (Protein cTAGE-2) (Cancer/testis antigen 21.2) (CT21.2) | None |
| Q99598 | TSNAX | S33 | ochoa | Translin-associated protein X (Translin-associated factor X) | Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis. {ECO:0000269|PubMed:12036294, ECO:0000269|PubMed:21552258}. |
| Q9BPZ7 | MAPKAP1 | S260 | ochoa|psp | Target of rapamycin complex 2 subunit MAPKAP1 (TORC2 subunit MAPKAP1) (Mitogen-activated protein kinase 2-associated protein 1) (Stress-activated map kinase-interacting protein 1) (SAPK-interacting protein 1) (mSIN1) | Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15467718, PubMed:16919458, PubMed:16962653, PubMed:17043309, PubMed:21806543, PubMed:28264193, PubMed:28968999, PubMed:30837283, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:16919458, PubMed:16962653, PubMed:21806543, PubMed:28264193, PubMed:28968999, PubMed:30837283, PubMed:35926713). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:16962653). Within the mTORC2 complex, MAPKAP1/SIN1 acts as a substrate adapter which recognizes and binds AGC protein kinase family members for phosphorylation by MTOR (PubMed:21806543, PubMed:28264193). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:28264193, PubMed:35926713). mTORC2 catalyzes the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657' (PubMed:30837283, PubMed:35926713). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:15467718). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (PubMed:15467718). MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation (PubMed:15988011). Inhibits HRAS and KRAS independently of mTORC2 complex (PubMed:17303383, PubMed:34380736, PubMed:35522713). Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription (PubMed:17054722). Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex (PubMed:23727834). {ECO:0000250|UniProtKB:Q8BKH7, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15988011, ECO:0000269|PubMed:16919458, ECO:0000269|PubMed:16962653, ECO:0000269|PubMed:17043309, ECO:0000269|PubMed:17054722, ECO:0000269|PubMed:17303383, ECO:0000269|PubMed:21806543, ECO:0000269|PubMed:23727834, ECO:0000269|PubMed:28264193, ECO:0000269|PubMed:28968999, ECO:0000269|PubMed:30837283, ECO:0000269|PubMed:34380736, ECO:0000269|PubMed:35522713, ECO:0000269|PubMed:35926713}.; FUNCTION: [Isoform 4]: In contrast to isoform 1, isoform 2 and isoform 6, isoform 4 is not a component of the a mTORC2 complex. {ECO:0000269|PubMed:26263164}. |
| Q9BQ39 | DDX50 | S22 | ochoa | ATP-dependent RNA helicase DDX50 (EC 3.6.4.13) (DEAD box protein 50) (Gu-beta) (Nucleolar protein Gu2) | ATP-dependent RNA helicase that may play a role in various aspects of RNA metabolism including pre-mRNA splicing or ribosomal RNA production (PubMed:12027455). Also acts as a viral restriction factor and promotes the activation of the NF-kappa-B and IRF3 signaling pathways following its stimulation with viral RNA or infection with RNA and DNA viruses (PubMed:35215908). For instance, decreases vaccinia virus, herpes simplex virus, Zika virus or dengue virus replication during the early stage of infection (PubMed:28181036, PubMed:35215908). Mechanistically, acts via the adapter TICAM1 and independently of the DDX1-DDX21-DHX36 helicase complex to induce the production of interferon-beta (PubMed:35215908). {ECO:0000269|PubMed:12027455, ECO:0000269|PubMed:28181036, ECO:0000269|PubMed:35215908}. |
| Q9BQ39 | DDX50 | S113 | ochoa | ATP-dependent RNA helicase DDX50 (EC 3.6.4.13) (DEAD box protein 50) (Gu-beta) (Nucleolar protein Gu2) | ATP-dependent RNA helicase that may play a role in various aspects of RNA metabolism including pre-mRNA splicing or ribosomal RNA production (PubMed:12027455). Also acts as a viral restriction factor and promotes the activation of the NF-kappa-B and IRF3 signaling pathways following its stimulation with viral RNA or infection with RNA and DNA viruses (PubMed:35215908). For instance, decreases vaccinia virus, herpes simplex virus, Zika virus or dengue virus replication during the early stage of infection (PubMed:28181036, PubMed:35215908). Mechanistically, acts via the adapter TICAM1 and independently of the DDX1-DDX21-DHX36 helicase complex to induce the production of interferon-beta (PubMed:35215908). {ECO:0000269|PubMed:12027455, ECO:0000269|PubMed:28181036, ECO:0000269|PubMed:35215908}. |
| Q9BRF8 | CPPED1 | S294 | ochoa | Serine/threonine-protein phosphatase CPPED1 (EC 3.1.3.16) (Calcineurin-like phosphoesterase domain-containing protein 1) (Complete S-transactivated protein 1) | Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes. {ECO:0000269|PubMed:23799035, ECO:0000269|PubMed:23939394}. |
| Q9BRV8 | SIKE1 | S133 | psp | Suppressor of IKBKE 1 (Suppressor of IKK-epsilon) | Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and RIGI. Does not inhibit NF-kappa-B activation pathways (PubMed:16281057). Associates with the striatin-interacting phosphatase and kinase (STRIPAK) core complex, forming the extended (SIKE1:SLMAP)STRIPAK complex (PubMed:30622739). The (SIKE1:SLMAP)STRIPAK complex dephosphorylates STK3 leading to the inhibition of Hippo signaling and the control of cell growth (PubMed:30622739). {ECO:0000269|PubMed:16281057, ECO:0000269|PubMed:30622739}. |
| Q9H000 | MKRN2 | S366 | ochoa | E3 ubiquitin-protein ligase makorin-2 (EC 2.3.2.27) (RING finger protein 62) (RING-type E3 ubiquitin transferase makorin-2) | E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (By similarity). Promotes the polyubiquitination and proteasome-dependent degradation of RELA/p65, thereby suppressing RELA-mediated NF-kappaB transactivation and negatively regulating inflammatory responses (By similarity). Plays a role in the regulation of spermiation and in male fertility (By similarity). {ECO:0000250|UniProtKB:Q9ERV1}. |
| Q9HB71 | CACYBP | S180 | ochoa | Calcyclin-binding protein (CacyBP) (hCacyBP) (S100A6-binding protein) (Siah-interacting protein) | May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1). {ECO:0000269|PubMed:16085652}. |
| Q9HCK1 | ZDBF2 | S957 | ochoa | DBF4-type zinc finger-containing protein 2 | None |
| Q9NSE4 | IARS2 | S668 | ochoa | Isoleucine--tRNA ligase, mitochondrial (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IleRS) | Aminoacyl-tRNA synthetase that catalyzes the specific attachment of isoleucine to its cognate tRNA (tRNA(Ile)). {ECO:0000250|UniProtKB:P00956}. |
| Q9NSI6 | BRWD1 | S2131 | ochoa | Bromodomain and WD repeat-containing protein 1 (WD repeat-containing protein 9) | May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000250, ECO:0000269|PubMed:21834987}. |
| Q9NX63 | CHCHD3 | S179 | ochoa | MICOS complex subunit MIC19 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 3) | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (PubMed:25781180, PubMed:32567732, PubMed:33130824). Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:25781180, PubMed:32567732, PubMed:33130824). Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription (PubMed:22567091). {ECO:0000269|PubMed:22567091, ECO:0000269|PubMed:25781180, ECO:0000269|PubMed:32567732, ECO:0000269|PubMed:33130824}. |
| Q9P244 | LRFN1 | S642 | ochoa | Leucine-rich repeat and fibronectin type III domain-containing protein 1 (Synaptic adhesion-like molecule 2) | Promotes neurite outgrowth in hippocampal neurons. Involved in the regulation and maintenance of excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1 (By similarity). {ECO:0000250}. |
| Q9P246 | STIM2 | S346 | ochoa | Stromal interaction molecule 2 | Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx. {ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16860747, ECO:0000269|PubMed:17905723, ECO:0000269|PubMed:18160041, ECO:0000269|PubMed:21217057, ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:23359669}. |
| Q9UHB6 | LIMA1 | S331 | ochoa | LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) | Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}. |
| Q9UHD1 | CHORDC1 | S125 | ochoa | Cysteine and histidine-rich domain-containing protein 1 (CHORD domain-containing protein 1) (CHORD-containing protein 1) (CHP-1) (Protein morgana) | Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2 (PubMed:20230755). Proposed to act as co-chaperone for HSP90 (PubMed:20230755). May play a role in the regulation of NOD1 via a HSP90 chaperone complex (PubMed:20230755). In vitro, has intrinsic chaperone activity (PubMed:20230755). This function may be achieved by inhibiting association of ROCK2 with NPM1 (PubMed:20230755). Plays a role in ensuring the localization of the tyrosine kinase receptor EGFR to the plasma membrane, and thus ensures the subsequent regulation of EGFR activity and EGF-induced actin cytoskeleton remodeling (PubMed:32053105). Involved in stress response (PubMed:20230755). Prevents tumorigenesis (PubMed:20230755). {ECO:0000269|PubMed:20230755, ECO:0000269|PubMed:32053105}. |
| Q9UIF9 | BAZ2A | S1155 | ochoa | Bromodomain adjacent to zinc finger domain protein 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3) | Regulatory subunit of the ATP-dependent NoRC-1 and NoRC-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Directly stimulates the ATPase activity of SMARCA5 in the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). The NoRC-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NoRC-5 ISWI chromatin remodeling complex, mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription (By similarity). Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac (By similarity). Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity). {ECO:0000250|UniProtKB:Q91YE5, ECO:0000269|PubMed:28801535}. |
| Q9UKX2 | MYH2 | S1482 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UKX3 | MYH13 | S1480 | ochoa | Myosin-13 (Myosin heavy chain 13) (Myosin heavy chain, skeletal muscle, extraocular) (MyHC-EO) (Myosin heavy chain, skeletal muscle, laryngeal) (MyHC-IIL) (Superfast myosin) | Fast twitching myosin mediating the high-velocity and low-tension contractions of specific striated muscles. {ECO:0000269|PubMed:23908353}. |
| Q9ULM0 | PLEKHH1 | S566 | ochoa | Pleckstrin homology domain-containing family H member 1 (PH domain-containing family H member 1) | None |
| Q9UPM8 | AP4E1 | S700 | ochoa | AP-4 complex subunit epsilon-1 (AP-4 adaptor complex subunit epsilon) (Adaptor-related protein complex 4 subunit epsilon-1) (Epsilon subunit of AP-4) (Epsilon-adaptin) | Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways (PubMed:10066790, PubMed:10436028). AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (Probable). {ECO:0000269|PubMed:10066790, ECO:0000269|PubMed:10436028, ECO:0000305|PubMed:10066790, ECO:0000305|PubMed:10436028}. |
| Q9Y623 | MYH4 | S1480 | ochoa | Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) | Muscle contraction. |
| Q9Y6N9 | USH1C | S283 | ochoa | Harmonin (Antigen NY-CO-38/NY-CO-37) (Autoimmune enteropathy-related antigen AIE-75) (Protein PDZ-73) (Renal carcinoma antigen NY-REN-3) (Usher syndrome type-1C protein) | Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal development and maintenance of cochlear hair cell bundles (By similarity). As part of the intermicrovillar adhesion complex/IMAC plays a role in brush border differentiation, controlling microvilli organization and length. Probably plays a central regulatory role in the assembly of the complex, recruiting CDHR2, CDHR5 and MYO7B to the microvilli tips (PubMed:24725409, PubMed:26812018). {ECO:0000250|UniProtKB:Q9ES64, ECO:0000269|PubMed:24725409, ECO:0000269|PubMed:26812018}. |
| P26373 | RPL13 | S181 | Sugiyama | Large ribosomal subunit protein eL13 (60S ribosomal protein L13) (Breast basic conserved protein 1) | Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:31630789, PubMed:32669547). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (Probable). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (Probable). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (Probable). As part of the LSU, it is probably required for its formation and the maturation of rRNAs (PubMed:31630789). Plays a role in bone development (PubMed:31630789). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:31630789, ECO:0000269|PubMed:32669547}. |
| P07686 | HEXB | S261 | Sugiyama | Beta-hexosaminidase subunit beta (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit beta) (Hexosaminidase subunit B) (Cervical cancer proto-oncogene 7 protein) (HCC-7) (N-acetyl-beta-glucosaminidase subunit beta) [Cleaved into: Beta-hexosaminidase subunit beta chain B; Beta-hexosaminidase subunit beta chain A] | Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides (PubMed:11707436, PubMed:8123671, PubMed:8672428, PubMed:9694901). The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide (PubMed:11707436). Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A (PubMed:8123671, PubMed:8672428, PubMed:9694901). During fertilization is responsible, at least in part, for the zona block to polyspermy. Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and inactivates the sperm galactosyltransferase-binding site, accounting for the block in sperm binding to the zona pellucida (By similarity). {ECO:0000250|UniProtKB:P20060, ECO:0000269|PubMed:11707436, ECO:0000269|PubMed:8123671, ECO:0000269|PubMed:8672428, ECO:0000269|PubMed:9694901}. |
| Q9NR50 | EIF2B3 | S260 | Sugiyama | Translation initiation factor eIF2B subunit gamma (eIF2B GDP-GTP exchange factor subunit gamma) | Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit (PubMed:25858979, PubMed:27023709, PubMed:31048492). Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed (PubMed:25858979, PubMed:31048492). {ECO:0000269|PubMed:25858979, ECO:0000269|PubMed:27023709, ECO:0000269|PubMed:31048492}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-390522 | Striated Muscle Contraction | 0.000114 | 3.942 |
| R-HSA-426486 | Small interfering RNA (siRNA) biogenesis | 0.001433 | 2.844 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.001132 | 2.946 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.000947 | 3.024 |
| R-HSA-180024 | DARPP-32 events | 0.001339 | 2.873 |
| R-HSA-3656248 | Defective HEXB causes GM2G2 (Hyaluronan metabolism) | 0.012099 | 1.917 |
| R-HSA-72731 | Recycling of eIF2:GDP | 0.059061 | 1.229 |
| R-HSA-9634635 | Estrogen-stimulated signaling through PRKCZ | 0.070452 | 1.152 |
| R-HSA-5358493 | Synthesis of diphthamide-EEF2 | 0.087283 | 1.059 |
| R-HSA-3928664 | Ephrin signaling | 0.130706 | 0.884 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.033659 | 1.473 |
| R-HSA-167161 | HIV Transcription Initiation | 0.036301 | 1.440 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.036301 | 1.440 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.151644 | 0.819 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.151644 | 0.819 |
| R-HSA-156902 | Peptide chain elongation | 0.021759 | 1.662 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.021759 | 1.662 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.192034 | 0.717 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.070005 | 1.155 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.070005 | 1.155 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.196947 | 0.706 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.075175 | 1.124 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.201831 | 0.695 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.201831 | 0.695 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.211510 | 0.675 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.211510 | 0.675 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.216305 | 0.665 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.087687 | 1.057 |
| R-HSA-380287 | Centrosome maturation | 0.091370 | 1.039 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.225810 | 0.646 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.244480 | 0.612 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.112385 | 0.949 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.112385 | 0.949 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.124329 | 0.905 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.126349 | 0.898 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.134506 | 0.871 |
| R-HSA-192823 | Viral mRNA Translation | 0.153267 | 0.815 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.163902 | 0.785 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.122318 | 0.913 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.174665 | 0.758 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.041815 | 1.379 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.174665 | 0.758 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.243291 | 0.614 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.039021 | 1.409 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.053703 | 1.270 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.046144 | 1.336 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.136564 | 0.865 |
| R-HSA-165158 | Activation of AKT2 | 0.041715 | 1.380 |
| R-HSA-164843 | 2-LTR circle formation | 0.076096 | 1.119 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.036301 | 1.440 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.211510 | 0.675 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.166045 | 0.780 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.166045 | 0.780 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.136564 | 0.865 |
| R-HSA-1268020 | Mitochondrial protein import | 0.068309 | 1.166 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.146955 | 0.833 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.024761 | 1.606 |
| R-HSA-446107 | Type I hemidesmosome assembly | 0.064774 | 1.189 |
| R-HSA-9927354 | Co-stimulation by ICOS | 0.064774 | 1.189 |
| R-HSA-8949613 | Cristae formation | 0.017525 | 1.756 |
| R-HSA-1855191 | Synthesis of IPs in the nucleus | 0.103813 | 0.984 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 0.130706 | 0.884 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.235201 | 0.629 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.136564 | 0.865 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.023909 | 1.621 |
| R-HSA-912631 | Regulation of signaling by CBL | 0.135988 | 0.866 |
| R-HSA-9620244 | Long-term potentiation | 0.172083 | 0.764 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 0.109257 | 0.962 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.216305 | 0.665 |
| R-HSA-6798695 | Neutrophil degranulation | 0.166983 | 0.777 |
| R-HSA-203927 | MicroRNA (miRNA) biogenesis | 0.172083 | 0.764 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.085863 | 1.066 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.151157 | 0.821 |
| R-HSA-1855167 | Synthesis of pyrophosphates in the cytosol | 0.013748 | 1.862 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.045463 | 1.342 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.108475 | 0.965 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.138629 | 0.858 |
| R-HSA-68877 | Mitotic Prometaphase | 0.041007 | 1.387 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.005002 | 2.301 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.198713 | 0.702 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.026021 | 1.585 |
| R-HSA-72766 | Translation | 0.140158 | 0.853 |
| R-HSA-2022857 | Keratan sulfate degradation | 0.141238 | 0.850 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.221072 | 0.655 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.149053 | 0.827 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.089280 | 1.049 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.045463 | 1.342 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.040479 | 1.393 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.034970 | 1.456 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.225810 | 0.646 |
| R-HSA-167172 | Transcription of the HIV genome | 0.078688 | 1.104 |
| R-HSA-444257 | RSK activation | 0.064774 | 1.189 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.151644 | 0.819 |
| R-HSA-392451 | G beta:gamma signalling through PI3Kgamma | 0.161925 | 0.791 |
| R-HSA-5694530 | Cargo concentration in the ER | 0.201831 | 0.695 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.221072 | 0.655 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.230520 | 0.637 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.155383 | 0.809 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.080117 | 1.096 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.227603 | 0.643 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.149053 | 0.827 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 0.059061 | 1.229 |
| R-HSA-173599 | Formation of the active cofactor, UDP-glucuronate | 0.103813 | 0.984 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 0.109257 | 0.962 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.028615 | 1.543 |
| R-HSA-3000157 | Laminin interactions | 0.172083 | 0.764 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.211510 | 0.675 |
| R-HSA-211000 | Gene Silencing by RNA | 0.036551 | 1.437 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.239854 | 0.620 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.168193 | 0.774 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.047189 | 1.326 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.151157 | 0.821 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.156800 | 0.805 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.110426 | 0.957 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.074613 | 1.127 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.033558 | 1.474 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.089523 | 1.048 |
| R-HSA-3371556 | Cellular response to heat stress | 0.198713 | 0.702 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.013748 | 1.862 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 0.161925 | 0.791 |
| R-HSA-2160916 | Hyaluronan degradation | 0.172083 | 0.764 |
| R-HSA-2024101 | CS/DS degradation | 0.216305 | 0.665 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.244480 | 0.612 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.017525 | 1.756 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.086949 | 1.061 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.116332 | 0.934 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.152290 | 0.817 |
| R-HSA-69275 | G2/M Transition | 0.129909 | 0.886 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.042108 | 1.376 |
| R-HSA-9675108 | Nervous system development | 0.161980 | 0.791 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.132639 | 0.877 |
| R-HSA-162592 | Integration of provirus | 0.087283 | 1.059 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 0.109257 | 0.962 |
| R-HSA-3295583 | TRP channels | 0.177116 | 0.752 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.225810 | 0.646 |
| R-HSA-162587 | HIV Life Cycle | 0.022505 | 1.648 |
| R-HSA-68886 | M Phase | 0.230847 | 0.637 |
| R-HSA-2142845 | Hyaluronan metabolism | 0.221072 | 0.655 |
| R-HSA-162906 | HIV Infection | 0.064584 | 1.190 |
| R-HSA-168255 | Influenza Infection | 0.120520 | 0.919 |
| R-HSA-8876725 | Protein methylation | 0.109257 | 0.962 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.221072 | 0.655 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.153701 | 0.813 |
| R-HSA-9865881 | Complex III assembly | 0.167019 | 0.777 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.239854 | 0.620 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.100770 | 0.997 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 0.017525 | 1.756 |
| R-HSA-397014 | Muscle contraction | 0.013978 | 1.855 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.120046 | 0.921 |
| R-HSA-68875 | Mitotic Prophase | 0.196509 | 0.707 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 0.172083 | 0.764 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.163902 | 0.785 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.239911 | 0.620 |
| R-HSA-9669938 | Signaling by KIT in disease | 0.156800 | 0.805 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.020618 | 1.686 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.235201 | 0.629 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.236685 | 0.626 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.044612 | 1.351 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.192518 | 0.716 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.025053 | 1.601 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.163902 | 0.785 |
| R-HSA-194138 | Signaling by VEGF | 0.054412 | 1.264 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.028615 | 1.543 |
| R-HSA-397795 | G-protein beta:gamma signalling | 0.211510 | 0.675 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.166045 | 0.780 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.091370 | 1.039 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.032367 | 1.490 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 0.135988 | 0.866 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 0.146457 | 0.834 |
| R-HSA-111885 | Opioid Signalling | 0.033558 | 1.474 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.070005 | 1.155 |
| R-HSA-3322077 | Glycogen synthesis | 0.141238 | 0.850 |
| R-HSA-191273 | Cholesterol biosynthesis | 0.096978 | 1.013 |
| R-HSA-354192 | Integrin signaling | 0.211510 | 0.675 |
| R-HSA-8853659 | RET signaling | 0.230520 | 0.637 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.161764 | 0.791 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.004793 | 2.319 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.098869 | 1.005 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.171785 | 0.765 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.009788 | 2.009 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.211510 | 0.675 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.073438 | 1.134 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.189916 | 0.721 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.228216 | 0.642 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.114354 | 0.942 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.126349 | 0.898 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.093228 | 1.030 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.245536 | 0.610 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.116332 | 0.934 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.247783 | 0.606 |
| R-HSA-9664407 | Parasite infection | 0.247783 | 0.606 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.247783 | 0.606 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.249077 | 0.604 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.249077 | 0.604 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.249077 | 0.604 |
| R-HSA-379726 | Mitochondrial tRNA aminoacylation | 0.249077 | 0.604 |
| R-HSA-8982491 | Glycogen metabolism | 0.249077 | 0.604 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.249077 | 0.604 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.250030 | 0.602 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.253646 | 0.596 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.254527 | 0.594 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.258188 | 0.588 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.258188 | 0.588 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.262703 | 0.581 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.267190 | 0.573 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.271651 | 0.566 |
| R-HSA-5683826 | Surfactant metabolism | 0.271651 | 0.566 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.276084 | 0.559 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.276084 | 0.559 |
| R-HSA-3560782 | Diseases associated with glycosaminoglycan metabolism | 0.276084 | 0.559 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.276084 | 0.559 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.277028 | 0.557 |
| R-HSA-9609507 | Protein localization | 0.279277 | 0.554 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.280491 | 0.552 |
| R-HSA-9675135 | Diseases of DNA repair | 0.280491 | 0.552 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.281527 | 0.550 |
| R-HSA-1989781 | PPARA activates gene expression | 0.283775 | 0.547 |
| R-HSA-1640170 | Cell Cycle | 0.284001 | 0.547 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.284872 | 0.545 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.284872 | 0.545 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.286736 | 0.543 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.288271 | 0.540 |
| R-HSA-9711097 | Cellular response to starvation | 0.290518 | 0.537 |
| R-HSA-1638074 | Keratan sulfate/keratin metabolism | 0.293553 | 0.532 |
| R-HSA-109704 | PI3K Cascade | 0.297855 | 0.526 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.300649 | 0.522 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.303981 | 0.517 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.303981 | 0.517 |
| R-HSA-168249 | Innate Immune System | 0.305951 | 0.514 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.306380 | 0.514 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.306380 | 0.514 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.306380 | 0.514 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.306380 | 0.514 |
| R-HSA-156588 | Glucuronidation | 0.314803 | 0.502 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.318977 | 0.496 |
| R-HSA-1793185 | Chondroitin sulfate/dermatan sulfate metabolism | 0.318977 | 0.496 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.319631 | 0.495 |
| R-HSA-418555 | G alpha (s) signalling events | 0.321861 | 0.492 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.323125 | 0.491 |
| R-HSA-5578775 | Ion homeostasis | 0.323125 | 0.491 |
| R-HSA-112399 | IRS-mediated signalling | 0.327248 | 0.485 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.327248 | 0.485 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.328540 | 0.483 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.330762 | 0.480 |
| R-HSA-191859 | snRNP Assembly | 0.335420 | 0.474 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.335420 | 0.474 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.335420 | 0.474 |
| R-HSA-168256 | Immune System | 0.335453 | 0.474 |
| R-HSA-379724 | tRNA Aminoacylation | 0.339470 | 0.469 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.343494 | 0.464 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.343494 | 0.464 |
| R-HSA-112316 | Neuronal System | 0.347282 | 0.459 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.347495 | 0.459 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.347495 | 0.459 |
| R-HSA-8957322 | Metabolism of steroids | 0.348884 | 0.457 |
| R-HSA-6799198 | Complex I biogenesis | 0.351471 | 0.454 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.355423 | 0.449 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.355423 | 0.449 |
| R-HSA-449147 | Signaling by Interleukins | 0.357467 | 0.447 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.359352 | 0.444 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.359456 | 0.444 |
| R-HSA-983712 | Ion channel transport | 0.361647 | 0.442 |
| R-HSA-5617833 | Cilium Assembly | 0.363834 | 0.439 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.367138 | 0.435 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.370996 | 0.431 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.370996 | 0.431 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.378642 | 0.422 |
| R-HSA-9840310 | Glycosphingolipid catabolism | 0.378642 | 0.422 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.378642 | 0.422 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.378720 | 0.422 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.382430 | 0.417 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.385550 | 0.414 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.386196 | 0.413 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.389939 | 0.409 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.390258 | 0.409 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.392005 | 0.407 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.393659 | 0.405 |
| R-HSA-8852135 | Protein ubiquitination | 0.397357 | 0.401 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.397357 | 0.401 |
| R-HSA-9824446 | Viral Infection Pathways | 0.399135 | 0.399 |
| R-HSA-73894 | DNA Repair | 0.408286 | 0.389 |
| R-HSA-4086400 | PCP/CE pathway | 0.408316 | 0.389 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.408316 | 0.389 |
| R-HSA-9659379 | Sensory processing of sound | 0.411926 | 0.385 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.413299 | 0.384 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.415513 | 0.381 |
| R-HSA-9833482 | PKR-mediated signaling | 0.415513 | 0.381 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.419079 | 0.378 |
| R-HSA-68882 | Mitotic Anaphase | 0.421716 | 0.375 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.422623 | 0.374 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.423811 | 0.373 |
| R-HSA-74160 | Gene expression (Transcription) | 0.437402 | 0.359 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 0.440026 | 0.357 |
| R-HSA-2262752 | Cellular responses to stress | 0.447148 | 0.350 |
| R-HSA-422475 | Axon guidance | 0.453085 | 0.344 |
| R-HSA-202424 | Downstream TCR signaling | 0.453574 | 0.343 |
| R-HSA-72312 | rRNA processing | 0.454758 | 0.342 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.463521 | 0.334 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.463521 | 0.334 |
| R-HSA-8939211 | ESR-mediated signaling | 0.464865 | 0.333 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.470053 | 0.328 |
| R-HSA-1474290 | Collagen formation | 0.470053 | 0.328 |
| R-HSA-5663205 | Infectious disease | 0.472099 | 0.326 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.473289 | 0.325 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.479703 | 0.319 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 0.479703 | 0.319 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.479703 | 0.319 |
| R-HSA-418594 | G alpha (i) signalling events | 0.484800 | 0.314 |
| R-HSA-70171 | Glycolysis | 0.492300 | 0.308 |
| R-HSA-1483255 | PI Metabolism | 0.498485 | 0.302 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.502751 | 0.299 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.507781 | 0.294 |
| R-HSA-392499 | Metabolism of proteins | 0.519280 | 0.285 |
| R-HSA-202403 | TCR signaling | 0.525407 | 0.280 |
| R-HSA-388396 | GPCR downstream signalling | 0.534522 | 0.272 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.536126 | 0.271 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.536908 | 0.270 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.541878 | 0.266 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.545253 | 0.263 |
| R-HSA-9658195 | Leishmania infection | 0.548870 | 0.261 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.548870 | 0.261 |
| R-HSA-70326 | Glucose metabolism | 0.550897 | 0.259 |
| R-HSA-5693538 | Homology Directed Repair | 0.553644 | 0.257 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.556427 | 0.255 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.567133 | 0.246 |
| R-HSA-1660662 | Glycosphingolipid metabolism | 0.567133 | 0.246 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.567133 | 0.246 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.569782 | 0.244 |
| R-HSA-69481 | G2/M Checkpoints | 0.580218 | 0.236 |
| R-HSA-199991 | Membrane Trafficking | 0.584724 | 0.233 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.587880 | 0.231 |
| R-HSA-5576891 | Cardiac conduction | 0.592911 | 0.227 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.607643 | 0.216 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.620173 | 0.207 |
| R-HSA-372790 | Signaling by GPCR | 0.623690 | 0.205 |
| R-HSA-212436 | Generic Transcription Pathway | 0.627040 | 0.203 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.628756 | 0.202 |
| R-HSA-1474244 | Extracellular matrix organization | 0.632744 | 0.199 |
| R-HSA-9610379 | HCMV Late Events | 0.657282 | 0.182 |
| R-HSA-5619102 | SLC transporter disorders | 0.677739 | 0.169 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.679828 | 0.168 |
| R-HSA-1643685 | Disease | 0.681584 | 0.166 |
| R-HSA-9679506 | SARS-CoV Infections | 0.685214 | 0.164 |
| R-HSA-72306 | tRNA processing | 0.685579 | 0.164 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.687510 | 0.163 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.695115 | 0.158 |
| R-HSA-611105 | Respiratory electron transport | 0.700698 | 0.154 |
| R-HSA-913531 | Interferon Signaling | 0.708007 | 0.150 |
| R-HSA-3781865 | Diseases of glycosylation | 0.711562 | 0.148 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 0.727131 | 0.138 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.728307 | 0.138 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.728808 | 0.137 |
| R-HSA-9609690 | HCMV Early Events | 0.732133 | 0.135 |
| R-HSA-428157 | Sphingolipid metabolism | 0.740270 | 0.131 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.743455 | 0.129 |
| R-HSA-72172 | mRNA Splicing | 0.746602 | 0.127 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.748688 | 0.126 |
| R-HSA-8953854 | Metabolism of RNA | 0.770898 | 0.113 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.778795 | 0.109 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.789468 | 0.103 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 0.795879 | 0.099 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.805736 | 0.094 |
| R-HSA-4839726 | Chromatin organization | 0.808126 | 0.093 |
| R-HSA-9609646 | HCMV Infection | 0.809310 | 0.092 |
| R-HSA-597592 | Post-translational protein modification | 0.814113 | 0.089 |
| R-HSA-416476 | G alpha (q) signalling events | 0.825145 | 0.083 |
| R-HSA-446728 | Cell junction organization | 0.839677 | 0.076 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.850251 | 0.070 |
| R-HSA-1483257 | Phospholipid metabolism | 0.855725 | 0.068 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.856618 | 0.067 |
| R-HSA-195721 | Signaling by WNT | 0.858387 | 0.066 |
| R-HSA-109582 | Hemostasis | 0.873150 | 0.059 |
| R-HSA-1500931 | Cell-Cell communication | 0.873368 | 0.059 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.878761 | 0.056 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.891606 | 0.050 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.895581 | 0.048 |
| R-HSA-1280218 | Adaptive Immune System | 0.895812 | 0.048 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.904517 | 0.044 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.920639 | 0.036 |
| R-HSA-5668914 | Diseases of metabolism | 0.937030 | 0.028 |
| R-HSA-162582 | Signal Transduction | 0.946178 | 0.024 |
| R-HSA-556833 | Metabolism of lipids | 0.958273 | 0.019 |
| R-HSA-211859 | Biological oxidations | 0.965538 | 0.015 |
| R-HSA-1266738 | Developmental Biology | 0.984628 | 0.007 |
| R-HSA-382551 | Transport of small molecules | 0.986167 | 0.006 |
| R-HSA-1430728 | Metabolism | 0.998189 | 0.001 |
| R-HSA-9709957 | Sensory Perception | 0.999655 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
TBK1 |
0.764 | 0.232 | 1 | 0.622 |
PRKD1 |
0.763 | 0.168 | -3 | 0.725 |
IKKE |
0.762 | 0.227 | 1 | 0.641 |
PRKD2 |
0.762 | 0.203 | -3 | 0.702 |
COT |
0.762 | 0.059 | 2 | 0.833 |
IKKB |
0.761 | 0.093 | -2 | 0.748 |
MTOR |
0.756 | 0.031 | 1 | 0.564 |
CAMK1B |
0.756 | 0.171 | -3 | 0.755 |
CAMK2D |
0.756 | 0.138 | -3 | 0.724 |
RAF1 |
0.756 | 0.198 | 1 | 0.588 |
CAMK2G |
0.755 | 0.068 | 2 | 0.812 |
MAPKAPK3 |
0.755 | 0.168 | -3 | 0.711 |
CAMK2B |
0.754 | 0.156 | 2 | 0.807 |
MAPKAPK2 |
0.753 | 0.153 | -3 | 0.696 |
PIM1 |
0.753 | 0.169 | -3 | 0.730 |
PRKD3 |
0.752 | 0.205 | -3 | 0.697 |
PDHK4 |
0.752 | 0.033 | 1 | 0.581 |
IKKA |
0.751 | 0.039 | -2 | 0.757 |
CLK3 |
0.751 | 0.088 | 1 | 0.463 |
NDR2 |
0.751 | 0.067 | -3 | 0.710 |
PKN3 |
0.750 | 0.119 | -3 | 0.740 |
CDKL1 |
0.750 | 0.120 | -3 | 0.758 |
WNK1 |
0.750 | 0.156 | -2 | 0.804 |
MST4 |
0.750 | 0.132 | 2 | 0.834 |
DNAPK |
0.750 | 0.147 | 1 | 0.617 |
TSSK1 |
0.750 | 0.201 | -3 | 0.737 |
RSK2 |
0.750 | 0.135 | -3 | 0.723 |
PIM3 |
0.750 | 0.068 | -3 | 0.743 |
RSK3 |
0.749 | 0.118 | -3 | 0.737 |
CAMK2A |
0.749 | 0.150 | 2 | 0.823 |
MARK4 |
0.749 | 0.084 | 4 | 0.780 |
SRPK1 |
0.749 | 0.121 | -3 | 0.726 |
CDKL5 |
0.749 | 0.108 | -3 | 0.757 |
CDC7 |
0.748 | -0.063 | 1 | 0.435 |
P90RSK |
0.748 | 0.130 | -3 | 0.736 |
AMPKA1 |
0.748 | 0.152 | -3 | 0.731 |
DSTYK |
0.748 | -0.002 | 2 | 0.853 |
PRPK |
0.748 | -0.027 | -1 | 0.794 |
LATS2 |
0.747 | 0.076 | -5 | 0.668 |
BCKDK |
0.747 | 0.079 | -1 | 0.767 |
SRPK2 |
0.746 | 0.132 | -3 | 0.694 |
PDHK1 |
0.746 | 0.071 | 1 | 0.617 |
CHK1 |
0.746 | 0.173 | -3 | 0.736 |
AMPKA2 |
0.746 | 0.152 | -3 | 0.720 |
NUAK2 |
0.745 | 0.100 | -3 | 0.736 |
NDR1 |
0.745 | 0.102 | -3 | 0.725 |
PKACG |
0.744 | 0.106 | -2 | 0.660 |
ATR |
0.744 | -0.016 | 1 | 0.532 |
SIK |
0.743 | 0.135 | -3 | 0.693 |
GCN2 |
0.743 | -0.098 | 2 | 0.740 |
TSSK2 |
0.743 | 0.170 | -5 | 0.816 |
MAPKAPK5 |
0.743 | 0.107 | -3 | 0.715 |
PKN2 |
0.743 | 0.113 | -3 | 0.720 |
NLK |
0.742 | 0.008 | 1 | 0.524 |
NIK |
0.742 | 0.132 | -3 | 0.737 |
P70S6KB |
0.742 | 0.118 | -3 | 0.733 |
WNK3 |
0.742 | 0.043 | 1 | 0.566 |
MOS |
0.741 | -0.041 | 1 | 0.460 |
FAM20C |
0.741 | 0.038 | 2 | 0.633 |
MSK2 |
0.741 | 0.097 | -3 | 0.720 |
HIPK4 |
0.741 | 0.038 | 1 | 0.467 |
ERK5 |
0.741 | -0.023 | 1 | 0.523 |
NUAK1 |
0.741 | 0.082 | -3 | 0.719 |
ULK2 |
0.741 | -0.082 | 2 | 0.701 |
MSK1 |
0.740 | 0.112 | -3 | 0.724 |
MELK |
0.740 | 0.137 | -3 | 0.713 |
ICK |
0.740 | 0.083 | -3 | 0.754 |
ATM |
0.740 | 0.010 | 1 | 0.491 |
BMPR2 |
0.740 | -0.075 | -2 | 0.828 |
NEK7 |
0.739 | -0.072 | -3 | 0.661 |
HUNK |
0.738 | -0.022 | 2 | 0.729 |
CAMK4 |
0.737 | 0.073 | -3 | 0.710 |
CLK1 |
0.737 | 0.130 | -3 | 0.701 |
PKCD |
0.737 | 0.083 | 2 | 0.749 |
KIS |
0.737 | -0.004 | 1 | 0.432 |
CAMLCK |
0.736 | 0.055 | -2 | 0.754 |
PRKX |
0.736 | 0.147 | -3 | 0.637 |
CLK4 |
0.736 | 0.110 | -3 | 0.720 |
BRSK1 |
0.736 | 0.109 | -3 | 0.716 |
QSK |
0.736 | 0.091 | 4 | 0.750 |
RSK4 |
0.735 | 0.124 | -3 | 0.701 |
RIPK3 |
0.735 | -0.029 | 3 | 0.710 |
CAMK1G |
0.735 | 0.146 | -3 | 0.713 |
QIK |
0.735 | 0.081 | -3 | 0.704 |
SKMLCK |
0.735 | 0.008 | -2 | 0.760 |
MARK2 |
0.734 | 0.080 | 4 | 0.718 |
GRK6 |
0.734 | -0.003 | 1 | 0.461 |
CDK8 |
0.734 | -0.031 | 1 | 0.406 |
ULK1 |
0.734 | -0.088 | -3 | 0.661 |
MARK3 |
0.734 | 0.101 | 4 | 0.726 |
CAMK1D |
0.733 | 0.187 | -3 | 0.669 |
CHAK2 |
0.733 | -0.010 | -1 | 0.860 |
PKACB |
0.733 | 0.103 | -2 | 0.566 |
NIM1 |
0.733 | 0.027 | 3 | 0.738 |
BRSK2 |
0.733 | 0.085 | -3 | 0.708 |
TGFBR2 |
0.733 | -0.017 | -2 | 0.713 |
DAPK2 |
0.733 | 0.022 | -3 | 0.743 |
NEK6 |
0.733 | -0.082 | -2 | 0.813 |
AURC |
0.733 | 0.068 | -2 | 0.531 |
SRPK3 |
0.732 | 0.089 | -3 | 0.719 |
MNK2 |
0.732 | 0.067 | -2 | 0.689 |
PLK3 |
0.732 | 0.062 | 2 | 0.733 |
NEK9 |
0.732 | -0.037 | 2 | 0.763 |
GRK1 |
0.732 | -0.002 | -2 | 0.735 |
PHKG1 |
0.732 | 0.070 | -3 | 0.712 |
MLK1 |
0.731 | -0.065 | 2 | 0.760 |
SGK3 |
0.731 | 0.127 | -3 | 0.705 |
LATS1 |
0.731 | 0.096 | -3 | 0.701 |
PAK1 |
0.731 | 0.045 | -2 | 0.673 |
DLK |
0.731 | -0.022 | 1 | 0.514 |
MASTL |
0.730 | -0.105 | -2 | 0.778 |
AKT2 |
0.730 | 0.132 | -3 | 0.682 |
CDK7 |
0.730 | -0.014 | 1 | 0.406 |
JNK2 |
0.730 | 0.027 | 1 | 0.397 |
RIPK1 |
0.729 | -0.052 | 1 | 0.500 |
YSK4 |
0.729 | 0.073 | 1 | 0.581 |
CLK2 |
0.729 | 0.117 | -3 | 0.718 |
MYLK4 |
0.729 | 0.078 | -2 | 0.660 |
CDK19 |
0.729 | -0.032 | 1 | 0.384 |
MARK1 |
0.728 | 0.077 | 4 | 0.737 |
TTBK2 |
0.728 | -0.031 | 2 | 0.626 |
GRK5 |
0.728 | -0.139 | -3 | 0.677 |
PAK3 |
0.728 | 0.005 | -2 | 0.682 |
NEK2 |
0.728 | 0.046 | 2 | 0.734 |
ANKRD3 |
0.727 | -0.035 | 1 | 0.553 |
DYRK2 |
0.727 | 0.012 | 1 | 0.409 |
PLK1 |
0.727 | -0.006 | -2 | 0.740 |
TGFBR1 |
0.727 | -0.006 | -2 | 0.748 |
AURB |
0.727 | 0.059 | -2 | 0.531 |
DCAMKL1 |
0.727 | 0.127 | -3 | 0.697 |
P70S6K |
0.726 | 0.122 | -3 | 0.700 |
PAK6 |
0.726 | 0.042 | -2 | 0.596 |
PIM2 |
0.726 | 0.110 | -3 | 0.716 |
MLK2 |
0.726 | -0.081 | 2 | 0.758 |
PKCB |
0.725 | 0.052 | 2 | 0.690 |
PKR |
0.725 | 0.041 | 1 | 0.503 |
ALK4 |
0.724 | -0.009 | -2 | 0.776 |
GRK4 |
0.724 | -0.092 | -2 | 0.774 |
JNK3 |
0.724 | -0.008 | 1 | 0.409 |
PKACA |
0.723 | 0.107 | -2 | 0.517 |
SMG1 |
0.723 | -0.052 | 1 | 0.526 |
PKCG |
0.723 | 0.048 | 2 | 0.699 |
CAMK1A |
0.723 | 0.183 | -3 | 0.648 |
MNK1 |
0.723 | 0.064 | -2 | 0.706 |
SBK |
0.723 | 0.170 | -3 | 0.613 |
DCAMKL2 |
0.723 | 0.101 | -3 | 0.711 |
CDK18 |
0.722 | -0.003 | 1 | 0.360 |
PKG2 |
0.722 | 0.062 | -2 | 0.580 |
PHKG2 |
0.722 | 0.096 | -3 | 0.692 |
SSTK |
0.722 | 0.132 | 4 | 0.723 |
WNK4 |
0.721 | 0.090 | -2 | 0.810 |
HIPK2 |
0.721 | 0.038 | 1 | 0.356 |
TLK2 |
0.721 | -0.018 | 1 | 0.520 |
PKCH |
0.721 | 0.052 | 2 | 0.659 |
DYRK1A |
0.720 | 0.054 | 1 | 0.453 |
HIPK1 |
0.720 | 0.052 | 1 | 0.423 |
CHK2 |
0.720 | 0.162 | -3 | 0.644 |
PAK2 |
0.719 | 0.005 | -2 | 0.660 |
BMPR1B |
0.719 | -0.026 | 1 | 0.369 |
ALK2 |
0.719 | -0.005 | -2 | 0.749 |
P38A |
0.719 | -0.008 | 1 | 0.451 |
MEK1 |
0.719 | -0.076 | 2 | 0.763 |
PKCA |
0.719 | 0.035 | 2 | 0.688 |
CDK13 |
0.718 | -0.041 | 1 | 0.400 |
DYRK4 |
0.718 | 0.023 | 1 | 0.364 |
CHAK1 |
0.718 | -0.026 | 2 | 0.696 |
P38B |
0.717 | -0.016 | 1 | 0.417 |
AKT1 |
0.717 | 0.104 | -3 | 0.677 |
IRE1 |
0.717 | -0.077 | 1 | 0.467 |
ERK1 |
0.717 | -0.021 | 1 | 0.419 |
PKCZ |
0.717 | -0.010 | 2 | 0.711 |
HIPK3 |
0.717 | 0.037 | 1 | 0.461 |
P38G |
0.716 | -0.011 | 1 | 0.330 |
AURA |
0.716 | 0.027 | -2 | 0.487 |
CDK9 |
0.716 | -0.031 | 1 | 0.412 |
PKN1 |
0.716 | 0.112 | -3 | 0.693 |
ACVR2B |
0.716 | -0.051 | -2 | 0.747 |
CDK17 |
0.716 | -0.019 | 1 | 0.319 |
PASK |
0.715 | 0.062 | -3 | 0.730 |
DRAK1 |
0.715 | -0.044 | 1 | 0.408 |
SGK1 |
0.715 | 0.144 | -3 | 0.645 |
PLK2 |
0.715 | 0.102 | -3 | 0.786 |
PKCT |
0.714 | 0.049 | 2 | 0.668 |
PLK4 |
0.714 | -0.022 | 2 | 0.520 |
SMMLCK |
0.714 | 0.063 | -3 | 0.739 |
ACVR2A |
0.714 | -0.054 | -2 | 0.727 |
GRK7 |
0.714 | -0.029 | 1 | 0.435 |
BRAF |
0.714 | -0.019 | -4 | 0.523 |
MLK3 |
0.714 | -0.081 | 2 | 0.707 |
SNRK |
0.714 | -0.030 | 2 | 0.581 |
ERK2 |
0.714 | -0.031 | 1 | 0.440 |
CDK12 |
0.714 | -0.031 | 1 | 0.391 |
CDK16 |
0.713 | 0.022 | 1 | 0.333 |
MEKK3 |
0.713 | -0.013 | 1 | 0.534 |
IRE2 |
0.712 | -0.067 | 2 | 0.669 |
PAK5 |
0.712 | 0.024 | -2 | 0.535 |
VRK2 |
0.712 | -0.187 | 1 | 0.527 |
CDK1 |
0.711 | -0.036 | 1 | 0.357 |
GRK2 |
0.711 | -0.056 | -2 | 0.696 |
CDK10 |
0.711 | 0.035 | 1 | 0.374 |
MST3 |
0.711 | 0.065 | 2 | 0.794 |
MRCKB |
0.711 | 0.151 | -3 | 0.694 |
MLK4 |
0.711 | -0.091 | 2 | 0.668 |
GSK3B |
0.710 | 0.015 | 4 | 0.475 |
PKCI |
0.710 | 0.050 | 2 | 0.681 |
DYRK3 |
0.710 | 0.034 | 1 | 0.421 |
DYRK1B |
0.710 | 0.017 | 1 | 0.366 |
TLK1 |
0.710 | -0.032 | -2 | 0.779 |
BMPR1A |
0.709 | -0.017 | 1 | 0.345 |
MEKK1 |
0.709 | -0.051 | 1 | 0.545 |
NEK5 |
0.709 | -0.030 | 1 | 0.539 |
AKT3 |
0.709 | 0.118 | -3 | 0.645 |
ZAK |
0.709 | -0.051 | 1 | 0.535 |
MRCKA |
0.709 | 0.140 | -3 | 0.695 |
CDK2 |
0.709 | -0.056 | 1 | 0.404 |
CDK5 |
0.709 | -0.044 | 1 | 0.402 |
PAK4 |
0.709 | 0.015 | -2 | 0.521 |
TTBK1 |
0.708 | -0.043 | 2 | 0.558 |
HRI |
0.708 | -0.094 | -2 | 0.799 |
GSK3A |
0.707 | 0.013 | 4 | 0.486 |
CDK14 |
0.707 | -0.001 | 1 | 0.394 |
CRIK |
0.706 | 0.170 | -3 | 0.683 |
TAO3 |
0.706 | 0.015 | 1 | 0.550 |
P38D |
0.706 | -0.028 | 1 | 0.367 |
PERK |
0.706 | -0.091 | -2 | 0.766 |
IRAK4 |
0.706 | -0.039 | 1 | 0.505 |
HPK1 |
0.705 | 0.194 | 1 | 0.621 |
MEKK2 |
0.705 | -0.046 | 2 | 0.725 |
IRAK1 |
0.705 | -0.072 | -1 | 0.794 |
MEK5 |
0.705 | -0.096 | 2 | 0.746 |
MST2 |
0.705 | 0.074 | 1 | 0.576 |
NEK11 |
0.705 | 0.010 | 1 | 0.566 |
CK1E |
0.705 | -0.061 | -3 | 0.397 |
CK1G1 |
0.705 | -0.026 | -3 | 0.377 |
DAPK3 |
0.704 | 0.060 | -3 | 0.715 |
ROCK2 |
0.704 | 0.147 | -3 | 0.709 |
GCK |
0.704 | 0.152 | 1 | 0.590 |
GAK |
0.704 | -0.015 | 1 | 0.483 |
PKG1 |
0.703 | 0.072 | -2 | 0.493 |
PKCE |
0.703 | 0.075 | 2 | 0.682 |
CK2A2 |
0.703 | -0.008 | 1 | 0.302 |
PDK1 |
0.703 | 0.024 | 1 | 0.537 |
NEK4 |
0.703 | 0.074 | 1 | 0.588 |
PRP4 |
0.702 | -0.053 | -3 | 0.617 |
MINK |
0.701 | 0.133 | 1 | 0.618 |
KHS1 |
0.701 | 0.205 | 1 | 0.645 |
LOK |
0.701 | 0.103 | -2 | 0.731 |
DAPK1 |
0.700 | 0.052 | -3 | 0.716 |
TAO2 |
0.700 | 0.021 | 2 | 0.797 |
MEKK6 |
0.700 | 0.022 | 1 | 0.569 |
MST1 |
0.700 | 0.118 | 1 | 0.589 |
JNK1 |
0.700 | -0.028 | 1 | 0.366 |
CDK3 |
0.700 | -0.029 | 1 | 0.329 |
MOK |
0.700 | 0.064 | 1 | 0.434 |
TAK1 |
0.699 | 0.057 | 1 | 0.572 |
ERK7 |
0.699 | -0.021 | 2 | 0.520 |
CAMKK1 |
0.699 | -0.086 | -2 | 0.728 |
HGK |
0.698 | 0.069 | 3 | 0.749 |
LKB1 |
0.698 | -0.057 | -3 | 0.654 |
PINK1 |
0.698 | -0.185 | 1 | 0.474 |
DMPK1 |
0.698 | 0.131 | -3 | 0.690 |
NEK8 |
0.697 | -0.081 | 2 | 0.748 |
KHS2 |
0.697 | 0.187 | 1 | 0.644 |
MAK |
0.697 | 0.060 | -2 | 0.610 |
SLK |
0.697 | 0.054 | -2 | 0.695 |
TNIK |
0.697 | 0.096 | 3 | 0.744 |
BUB1 |
0.697 | 0.095 | -5 | 0.821 |
GRK3 |
0.697 | -0.065 | -2 | 0.653 |
MAP3K15 |
0.696 | -0.009 | 1 | 0.555 |
CK1D |
0.696 | -0.064 | -3 | 0.343 |
CK1A2 |
0.695 | -0.052 | -3 | 0.353 |
CAMKK2 |
0.695 | -0.083 | -2 | 0.714 |
ROCK1 |
0.693 | 0.126 | -3 | 0.701 |
NEK1 |
0.693 | 0.013 | 1 | 0.542 |
NEK3 |
0.693 | -0.019 | 1 | 0.562 |
CK2A1 |
0.693 | -0.020 | 1 | 0.293 |
MPSK1 |
0.693 | -0.092 | 1 | 0.451 |
LRRK2 |
0.691 | -0.022 | 2 | 0.776 |
YSK1 |
0.689 | 0.015 | 2 | 0.747 |
CDK4 |
0.689 | -0.028 | 1 | 0.381 |
RIPK2 |
0.689 | -0.104 | 1 | 0.522 |
CDK6 |
0.687 | -0.042 | 1 | 0.392 |
PBK |
0.687 | -0.033 | 1 | 0.455 |
EEF2K |
0.685 | -0.061 | 3 | 0.720 |
PDHK3_TYR |
0.685 | 0.065 | 4 | 0.829 |
STK33 |
0.684 | -0.065 | 2 | 0.569 |
HASPIN |
0.683 | 0.062 | -1 | 0.820 |
MEK2 |
0.683 | -0.102 | 2 | 0.710 |
VRK1 |
0.683 | -0.141 | 2 | 0.751 |
NEK10_TYR |
0.678 | 0.121 | 1 | 0.584 |
BIKE |
0.677 | -0.022 | 1 | 0.407 |
RET |
0.676 | 0.068 | 1 | 0.566 |
TAO1 |
0.675 | 0.015 | 1 | 0.557 |
PDHK4_TYR |
0.675 | -0.029 | 2 | 0.851 |
BMPR2_TYR |
0.675 | 0.009 | -1 | 0.820 |
MAP2K7_TYR |
0.674 | -0.056 | 2 | 0.804 |
TESK1_TYR |
0.674 | -0.040 | 3 | 0.815 |
ASK1 |
0.674 | -0.042 | 1 | 0.546 |
LIMK2_TYR |
0.672 | 0.012 | -3 | 0.715 |
MAP2K6_TYR |
0.672 | -0.082 | -1 | 0.824 |
MAP2K4_TYR |
0.672 | -0.110 | -1 | 0.799 |
PDHK1_TYR |
0.671 | -0.068 | -1 | 0.832 |
DDR1 |
0.670 | -0.021 | 4 | 0.753 |
PINK1_TYR |
0.670 | -0.100 | 1 | 0.508 |
TYK2 |
0.670 | 0.001 | 1 | 0.581 |
JAK2 |
0.669 | -0.005 | 1 | 0.592 |
PKMYT1_TYR |
0.669 | -0.131 | 3 | 0.791 |
TTK |
0.668 | -0.051 | -2 | 0.732 |
OSR1 |
0.668 | -0.086 | 2 | 0.729 |
MST1R |
0.667 | -0.015 | 3 | 0.751 |
AAK1 |
0.667 | -0.003 | 1 | 0.351 |
YANK3 |
0.667 | -0.039 | 2 | 0.406 |
MYO3B |
0.665 | -0.038 | 2 | 0.763 |
INSRR |
0.664 | 0.004 | 3 | 0.723 |
EPHA6 |
0.664 | -0.023 | -1 | 0.795 |
MYO3A |
0.664 | -0.006 | 1 | 0.556 |
CSF1R |
0.664 | -0.029 | 3 | 0.739 |
CK1A |
0.664 | -0.088 | -3 | 0.265 |
ALPHAK3 |
0.663 | -0.068 | -1 | 0.710 |
LIMK1_TYR |
0.662 | -0.103 | 2 | 0.784 |
JAK3 |
0.662 | -0.065 | 1 | 0.533 |
FGFR2 |
0.662 | -0.035 | 3 | 0.767 |
EPHB4 |
0.661 | -0.051 | -1 | 0.763 |
JAK1 |
0.661 | 0.034 | 1 | 0.588 |
ROS1 |
0.660 | -0.045 | 3 | 0.729 |
TNK2 |
0.660 | -0.032 | 3 | 0.728 |
STLK3 |
0.659 | -0.086 | 1 | 0.528 |
TYRO3 |
0.659 | -0.101 | 3 | 0.740 |
SRMS |
0.659 | -0.059 | 1 | 0.469 |
EPHB1 |
0.657 | -0.062 | 1 | 0.485 |
DDR2 |
0.657 | 0.020 | 3 | 0.733 |
FGFR1 |
0.657 | -0.076 | 3 | 0.747 |
PDGFRB |
0.657 | -0.079 | 3 | 0.752 |
EPHA4 |
0.657 | -0.042 | 2 | 0.759 |
TNK1 |
0.656 | -0.003 | 3 | 0.720 |
ABL2 |
0.656 | -0.058 | -1 | 0.724 |
FLT3 |
0.655 | -0.057 | 3 | 0.719 |
FER |
0.655 | -0.110 | 1 | 0.488 |
AXL |
0.655 | -0.056 | 3 | 0.746 |
YES1 |
0.655 | -0.079 | -1 | 0.757 |
KIT |
0.654 | -0.073 | 3 | 0.738 |
KDR |
0.653 | -0.059 | 3 | 0.722 |
EPHB2 |
0.653 | -0.063 | -1 | 0.743 |
EPHB3 |
0.652 | -0.078 | -1 | 0.749 |
ABL1 |
0.652 | -0.080 | -1 | 0.713 |
TXK |
0.651 | -0.071 | 1 | 0.425 |
FGFR3 |
0.651 | -0.061 | 3 | 0.744 |
PDGFRA |
0.651 | -0.079 | 3 | 0.740 |
FGR |
0.650 | -0.137 | 1 | 0.493 |
HCK |
0.650 | -0.106 | -1 | 0.755 |
NTRK1 |
0.649 | -0.095 | -1 | 0.736 |
TEK |
0.649 | -0.077 | 3 | 0.693 |
FLT1 |
0.649 | -0.073 | -1 | 0.776 |
ITK |
0.649 | -0.095 | -1 | 0.750 |
TNNI3K_TYR |
0.649 | -0.071 | 1 | 0.517 |
MERTK |
0.649 | -0.090 | 3 | 0.740 |
LCK |
0.648 | -0.072 | -1 | 0.764 |
CK1G3 |
0.647 | -0.055 | -3 | 0.225 |
ERBB2 |
0.647 | -0.073 | 1 | 0.501 |
FLT4 |
0.646 | -0.087 | 3 | 0.719 |
BLK |
0.646 | -0.066 | -1 | 0.765 |
CSK |
0.646 | -0.031 | 2 | 0.741 |
LTK |
0.645 | -0.067 | 3 | 0.729 |
EPHA1 |
0.645 | -0.056 | 3 | 0.715 |
MET |
0.645 | -0.106 | 3 | 0.739 |
EGFR |
0.645 | -0.050 | 1 | 0.428 |
EPHA7 |
0.645 | -0.062 | 2 | 0.740 |
EPHA3 |
0.644 | -0.071 | 2 | 0.722 |
BTK |
0.644 | -0.127 | -1 | 0.704 |
ALK |
0.644 | -0.077 | 3 | 0.706 |
INSR |
0.643 | -0.098 | 3 | 0.689 |
EPHA5 |
0.643 | -0.050 | 2 | 0.734 |
NTRK2 |
0.643 | -0.133 | 3 | 0.704 |
FYN |
0.643 | -0.042 | -1 | 0.744 |
BMX |
0.641 | -0.083 | -1 | 0.645 |
TEC |
0.641 | -0.099 | -1 | 0.653 |
NTRK3 |
0.641 | -0.119 | -1 | 0.684 |
FGFR4 |
0.640 | -0.052 | -1 | 0.684 |
FRK |
0.639 | -0.080 | -1 | 0.759 |
EPHA8 |
0.638 | -0.059 | -1 | 0.748 |
YANK2 |
0.637 | -0.056 | 2 | 0.424 |
PTK2 |
0.637 | -0.015 | -1 | 0.746 |
PTK6 |
0.637 | -0.152 | -1 | 0.672 |
PTK2B |
0.636 | -0.106 | -1 | 0.699 |
LYN |
0.636 | -0.098 | 3 | 0.659 |
MATK |
0.635 | -0.080 | -1 | 0.671 |
WEE1_TYR |
0.635 | -0.126 | -1 | 0.713 |
EPHA2 |
0.634 | -0.049 | -1 | 0.701 |
SYK |
0.632 | -0.043 | -1 | 0.717 |
IGF1R |
0.631 | -0.076 | 3 | 0.635 |
SRC |
0.631 | -0.105 | -1 | 0.721 |
ERBB4 |
0.630 | -0.053 | 1 | 0.399 |
CK1G2 |
0.627 | -0.067 | -3 | 0.303 |
MUSK |
0.624 | -0.132 | 1 | 0.425 |
ZAP70 |
0.610 | -0.080 | -1 | 0.653 |
FES |
0.610 | -0.138 | -1 | 0.621 |