Motif 846 (n=120)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| O00160 | MYO1F | S1023 | ochoa | Unconventional myosin-If (Myosin-Ie) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity). {ECO:0000250}. |
| O00750 | PIK3C2B | S95 | ochoa | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (PI3K-C2-beta) (PtdIns-3-kinase C2 subunit beta) (EC 2.7.1.137) (EC 2.7.1.154) (C2-PI3K) (Phosphoinositide 3-kinase-C2-beta) | Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns (PubMed:10805725, PubMed:11533253, PubMed:9830063). Does not phosphorylate PtdIns(4,5)P2 (PubMed:9830063). May be involved in EGF and PDGF signaling cascades (PubMed:10805725). {ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11533253, ECO:0000269|PubMed:9830063}. |
| O14513 | NCKAP5 | S1311 | ochoa | Nck-associated protein 5 (NAP-5) (Peripheral clock protein) | None |
| O14654 | IRS4 | T208 | ochoa | Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160) | Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2. {ECO:0000269|PubMed:10531310, ECO:0000269|PubMed:10594015, ECO:0000269|PubMed:12639902, ECO:0000269|PubMed:17408801, ECO:0000269|PubMed:9553137}. |
| O60343 | TBC1D4 | S695 | ochoa | TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160) | May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake. {ECO:0000269|PubMed:15971998, ECO:0000269|PubMed:18771725, ECO:0000269|PubMed:22908308}. |
| O60759 | CYTIP | S212 | ochoa | Cytohesin-interacting protein (Cytohesin binder and regulator) (CYBR) (Cytohesin-associated scaffolding protein) (CASP) (Cytohesin-binding protein HE) (Cbp HE) (Pleckstrin homology Sec7 and coiled-coil domains-binding protein) | By its binding to cytohesin-1 (CYTH1), it modifies activation of ARFs by CYTH1 and its precise function may be to sequester CYTH1 in the cytoplasm. |
| O75533 | SF3B1 | S229 | ochoa | Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B1 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). {ECO:0000250|UniProtKB:Q99NB9, ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}. |
| P04792 | HSPB1 | S50 | ochoa | Heat shock protein beta-1 (HspB1) (28 kDa heat shock protein) (Estrogen-regulated 24 kDa protein) (Heat shock 27 kDa protein) (HSP 27) (Heat shock protein family B member 1) (Stress-responsive protein 27) (SRP27) | Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state (PubMed:10383393, PubMed:20178975). Plays a role in stress resistance and actin organization (PubMed:19166925). Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins (PubMed:23728742). {ECO:0000269|PubMed:10383393, ECO:0000269|PubMed:19166925, ECO:0000269|PubMed:20178975, ECO:0000269|PubMed:23728742}. |
| P06127 | CD5 | S428 | ochoa | T-cell surface glycoprotein CD5 (Lymphocyte antigen T1/Leu-1) (CD antigen CD5) | Lymphoid-specific receptor expressed by all T-cells and in a subset of B-cells known as B1a cells. Plays a role in the regulation of TCR and BCR signaling, thymocyte selection, T-cell effector differentiation and immune tolerance. Acts by interacting with several ligands expressed on B-cells such as CD5L or CD72 and thereby plays an important role in contact-mediated, T-dependent B-cell activation and in the maintenance of regulatory T and B-cell homeostasis. Functions as a negative regulator of TCR signaling during thymocyte development by associating with several signaling proteins including LCK, CD3Z chain, PI3K or CBL (PubMed:1384049, PubMed:1385158). Mechanistically, co-engagement of CD3 with CD5 enhances phosphorylated CBL recruitment leading to increased VAV1 phosphorylation and degradation (PubMed:23376399). Modulates B-cell biology through ERK1/2 activation in a Ca(2+)-dependent pathway via the non-selective Ca(2+) channel TRPC1, leading to IL-10 production (PubMed:27499044). {ECO:0000250|UniProtKB:P13379, ECO:0000269|PubMed:1384049, ECO:0000269|PubMed:1385158, ECO:0000269|PubMed:23376399, ECO:0000269|PubMed:27499044}. |
| P07942 | LAMB1 | S1222 | ochoa | Laminin subunit beta-1 (Laminin B1 chain) (Laminin-1 subunit beta) (Laminin-10 subunit beta) (Laminin-12 subunit beta) (Laminin-2 subunit beta) (Laminin-6 subunit beta) (Laminin-8 subunit beta) | Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Involved in the organization of the laminar architecture of cerebral cortex. It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons. Radial glial cells play a central role in cerebral cortical development, where they act both as the proliferative unit of the cerebral cortex and a scaffold for neurons migrating toward the pial surface. {ECO:0000269|PubMed:23472759}. |
| P08138 | NGFR | S354 | ochoa | Tumor necrosis factor receptor superfamily member 16 (Gp80-LNGFR) (Low affinity neurotrophin receptor p75NTR) (Low-affinity nerve growth factor receptor) (NGF receptor) (Low-affinity nerve growth factor receptor p75NGFR) (Low-affinity nerve growth factor receptor p75NGR) (p75 ICD) (CD antigen CD271) | Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF (PubMed:24908487). Plays an important role in differentiation and survival of specific neuronal populations during development (By similarity). Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA (PubMed:26646181). Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Necessary for the circadian oscillation of the clock genes BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCmgetaN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver (PubMed:23785138). Together with BFAR negatively regulates NF-kappa-B and JNK-related signaling pathways (PubMed:22566094). {ECO:0000250, ECO:0000250|UniProtKB:Q9Z0W1, ECO:0000269|PubMed:14966521, ECO:0000269|PubMed:23785138, ECO:0000269|PubMed:24908487, ECO:0000269|PubMed:26646181, ECO:0000269|PubMed:3022937}. |
| P10244 | MYBL2 | S472 | ochoa | Myb-related protein B (B-Myb) (Myb-like protein 2) | Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene. {ECO:0000269|PubMed:10770937}. |
| P17947 | SPI1 | S106 | ochoa | Transcription factor PU.1 (31 kDa-transforming protein) | Pioneer transcription factor, which controls hematopoietic cell fate by decompacting stem cell heterochromatin and allowing other transcription factors to enter otherwise inaccessible genomic sites. Once in open chromatin, can directly control gene expression by binding genetic regulatory elements and can also more broadly influence transcription by recruiting transcription factors, such as interferon regulatory factors (IRFs), to otherwise inaccessible genomic regions (PubMed:23658224, PubMed:33951726). Transcriptionally activates genes important for myeloid and lymphoid lineages, such as CSF1R (By similarity). Transcriptional activation from certain promoters, possibly containing low affinity binding sites, is achieved cooperatively with other transcription factors. FCER1A transactivation is achieved in cooperation with GATA1 (By similarity). May be particularly important for the pro- to pre-B cell transition (PubMed:33951726). Binds (via the ETS domain) onto the purine-rich DNA core sequence 5'-GAGGAA-3', also known as the PU-box (PubMed:33951726). In vitro can bind RNA and interfere with pre-mRNA splicing (By similarity). {ECO:0000250|UniProtKB:P17433, ECO:0000250|UniProtKB:Q6BDS1, ECO:0000269|PubMed:23658224, ECO:0000269|PubMed:33951726}. |
| P18031 | PTPN1 | S378 | ochoa|psp | Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B) | Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. {ECO:0000269|PubMed:18819921, ECO:0000269|PubMed:21135139, ECO:0000269|PubMed:22169477}. |
| P20585 | MSH3 | S33 | ochoa | DNA mismatch repair protein Msh3 (hMSH3) (Divergent upstream protein) (DUP) (Mismatch repair protein 1) (MRP1) | Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. |
| P22736 | NR4A1 | S341 | ochoa | Nuclear receptor subfamily 4immunitygroup A member 1 (Early response protein NAK1) (Nuclear hormone receptor NUR/77) (Nur77) (Orphan nuclear receptor HMR) (Orphan nuclear receptor TR3) (ST-59) (Testicular receptor 3) | Orphan nuclear receptor. Binds the NGFI-B response element (NBRE) 5'-AAAGGTCA-3' (PubMed:18690216, PubMed:8121493, PubMed:9315652). Binds 9-cis-retinoic acid outside of its ligand-binding (NR LBD) domain (PubMed:18690216). Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (PubMed:22983157). Regulates the inflammatory response in macrophages by regulating metabolic adaptations during inflammation, including repressing the transcription of genes involved in the citric acid cycle (TCA) (By similarity). Inhibits NF-kappa-B signaling by binding to low-affinity NF-kappa-B binding sites, such as at the IL2 promoter (PubMed:15466594). May act concomitantly with NR4A2 in regulating the expression of delayed-early genes during liver regeneration (By similarity). Plays a role in the vascular response to injury (By similarity). {ECO:0000250|UniProtKB:P12813, ECO:0000250|UniProtKB:P22829, ECO:0000269|PubMed:15466594, ECO:0000269|PubMed:18690216, ECO:0000269|PubMed:22983157, ECO:0000269|PubMed:8121493, ECO:0000269|PubMed:9315652}.; FUNCTION: In the cytosol, upon its detection of both bacterial lipopolysaccharide (LPS) and NBRE-containing mitochondrial DNA released by GSDMD pores during pyroptosis, it promotes non-canonical NLRP3 inflammasome activation by stimulating association of NLRP3 and NEK7. {ECO:0000250|UniProtKB:P12813}. |
| P29350 | PTPN6 | S138 | ochoa | Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Protein-tyrosine phosphatase SHP-1) (SH-PTP1) | Tyrosine phosphatase enzyme that plays important roles in controlling immune signaling pathways and fundamental physiological processes such as hematopoiesis (PubMed:14739280, PubMed:29925997). Dephosphorylates and negatively regulate several receptor tyrosine kinases (RTKs) such as EGFR, PDGFR and FGFR, thereby modulating their signaling activities (PubMed:21258366, PubMed:9733788). When recruited to immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing receptors such as immunoglobulin-like transcript 2/LILRB1, programmed cell death protein 1/PDCD1, CD3D, CD22, CLEC12A and other receptors involved in immune regulation, initiates their dephosphorylation and subsequently inhibits downstream signaling events (PubMed:11907092, PubMed:14739280, PubMed:37932456, PubMed:38166031). Modulates the signaling of several cytokine receptors including IL-4 receptor (PubMed:9065461). Additionally, targets multiple cytoplasmic signaling molecules including STING1, LCK or STAT1 among others involved in diverse cellular processes including modulation of T-cell activation or cGAS-STING signaling (PubMed:34811497, PubMed:38532423). Within the nucleus, negatively regulates the activity of some transcription factors such as NFAT5 via direct dephosphorylation. Also acts as a key transcriptional regulator of hepatic gluconeogenesis by controlling recruitment of RNA polymerase II to the PCK1 promoter together with STAT5A (PubMed:37595871). {ECO:0000269|PubMed:10574931, ECO:0000269|PubMed:11266449, ECO:0000269|PubMed:11907092, ECO:0000269|PubMed:14739280, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:29925997, ECO:0000269|PubMed:34811497, ECO:0000269|PubMed:37595871, ECO:0000269|PubMed:37932456, ECO:0000269|PubMed:38166031, ECO:0000269|PubMed:38532423, ECO:0000269|PubMed:9065461, ECO:0000269|PubMed:9733788}. |
| P29474 | NOS3 | S1179 | ochoa|psp | Nitric oxide synthase 3 (EC 1.14.13.39) (Constitutive NOS) (cNOS) (EC-NOS) (NOS type III) (NOSIII) (Nitric oxide synthase, endothelial) (Endothelial NOS) (eNOS) | Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway (PubMed:1378832). NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. {ECO:0000269|PubMed:1378832}.; FUNCTION: [Isoform eNOS13C]: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1. |
| P35869 | AHR | S693 | psp | Aryl hydrocarbon receptor (Ah receptor) (AhR) (Class E basic helix-loop-helix protein 76) (bHLHe76) | Ligand-activated transcription factor that enables cells to adapt to changing conditions by sensing compounds from the environment, diet, microbiome and cellular metabolism, and which plays important roles in development, immunity and cancer (PubMed:23275542, PubMed:30373764, PubMed:32818467, PubMed:7961644). Upon ligand binding, translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE) (PubMed:23275542, PubMed:30373764, PubMed:7961644). Regulates a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation (PubMed:12213388). Xenobiotics can act as ligands: upon xenobiotic-binding, activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene) (PubMed:7961644, PubMed:33193710). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons (PubMed:34521881, PubMed:7961644). Next to xenobiotics, natural ligands derived from plants, microbiota, and endogenous metabolism are potent AHR agonists (PubMed:18076143). Tryptophan (Trp) derivatives constitute an important class of endogenous AHR ligands (PubMed:32818467, PubMed:32866000). Acts as a negative regulator of anti-tumor immunity: indoles and kynurenic acid generated by Trp catabolism act as ligand and activate AHR, thereby promoting AHR-driven cancer cell motility and suppressing adaptive immunity (PubMed:32818467). Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1 (PubMed:28602820). Inhibits PER1 by repressing the CLOCK-BMAL1 heterodimer mediated transcriptional activation of PER1 (PubMed:28602820). The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28602820). {ECO:0000269|PubMed:23275542, ECO:0000269|PubMed:28602820, ECO:0000269|PubMed:30373764, ECO:0000269|PubMed:32818467, ECO:0000269|PubMed:32866000, ECO:0000269|PubMed:33193710, ECO:0000269|PubMed:34521881, ECO:0000269|PubMed:7961644, ECO:0000303|PubMed:12213388, ECO:0000303|PubMed:18076143}. |
| P46087 | NOP2 | S58 | ochoa | 28S rRNA (cytosine(4447)-C(5))-methyltransferase (EC 2.1.1.-) (Nucleolar protein 1) (Nucleolar protein 2 homolog) (Proliferating-cell nucleolar antigen p120) (Proliferation-associated nucleolar protein p120) | S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (PubMed:26196125). Required for efficient rRNA processing and 60S ribosomal subunit biogenesis (PubMed:24120868, PubMed:36161484). Regulates pre-rRNA processing through non-catalytic complex formation with box C/D snoRNAs and facilitates the recruitment of U3 and U8 snoRNAs to pre-90S ribosomal particles and their stable assembly into snoRNP complexes (PubMed:36161484). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (PubMed:24120868). {ECO:0000269|PubMed:24120868, ECO:0000269|PubMed:26196125, ECO:0000269|PubMed:36161484}. |
| P47756 | CAPZB | S192 | psp | F-actin-capping protein subunit beta (CapZ beta) | F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:A9XFX6, ECO:0000269|PubMed:21834987}. |
| P49918 | CDKN1C | S282 | psp | Cyclin-dependent kinase inhibitor 1C (Cyclin-dependent kinase inhibitor p57) (p57Kip2) | Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life. |
| P51116 | FXR2 | S637 | ochoa | RNA-binding protein FXR2 (FXR2P) (FMR1 autosomal homolog 2) | mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for adult hippocampal neurogenesis (By similarity). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (By similarity). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs: mRNAs storage into membraneless compartments regulates their translation and/or stability (By similarity). Acts as a regulator of adult hippocampal neurogenesis by regulating translation and/or stability of NOG mRNA, thereby preventing NOG protein expression in the dentate gyrus (By similarity). {ECO:0000250|UniProtKB:Q61584, ECO:0000250|UniProtKB:Q9WVR4}. |
| P52948 | NUP98 | S1064 | ochoa | Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)] | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC (PubMed:33097660). May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:33097660}.; FUNCTION: (Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro) (PubMed:23523133). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro) (PubMed:23523133). {ECO:0000269|PubMed:23523133}. |
| P55265 | ADAR | S814 | ochoa | Double-stranded RNA-specific adenosine deaminase (DRADA) (EC 3.5.4.37) (136 kDa double-stranded RNA-binding protein) (p136) (Interferon-inducible protein 4) (IFI-4) (K88DSRBP) | Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing (PubMed:12618436, PubMed:7565688, PubMed:7972084). This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins since the translational machinery read the inosine as a guanosine; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2) and serotonin (HTR2C) and GABA receptor (GABRA3). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alters their functional activities. Exhibits low-level editing at the GRIA2 Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Its viral RNA substrates include: hepatitis C virus (HCV), vesicular stomatitis virus (VSV), measles virus (MV), hepatitis delta virus (HDV), and human immunodeficiency virus type 1 (HIV-1). Exhibits either a proviral (HDV, MV, VSV and HIV-1) or an antiviral effect (HCV) and this can be editing-dependent (HDV and HCV), editing-independent (VSV and MV) or both (HIV-1). Impairs HCV replication via RNA editing at multiple sites. Enhances the replication of MV, VSV and HIV-1 through an editing-independent mechanism via suppression of EIF2AK2/PKR activation and function. Stimulates both the release and infectivity of HIV-1 viral particles by an editing-dependent mechanism where it associates with viral RNAs and edits adenosines in the 5'UTR and the Rev and Tat coding sequence. Can enhance viral replication of HDV via A-to-I editing at a site designated as amber/W, thereby changing an UAG amber stop codon to an UIG tryptophan (W) codon that permits synthesis of the large delta antigen (L-HDAg) which has a key role in the assembly of viral particles. However, high levels of ADAR1 inhibit HDV replication. {ECO:0000269|PubMed:12618436, ECO:0000269|PubMed:15556947, ECO:0000269|PubMed:15858013, ECO:0000269|PubMed:16120648, ECO:0000269|PubMed:16475990, ECO:0000269|PubMed:17079286, ECO:0000269|PubMed:19605474, ECO:0000269|PubMed:19651874, ECO:0000269|PubMed:19710021, ECO:0000269|PubMed:19908260, ECO:0000269|PubMed:21289159, ECO:0000269|PubMed:22278222, ECO:0000269|PubMed:7565688, ECO:0000269|PubMed:7972084}. |
| P78524 | DENND2B | S525 | ochoa | DENN domain-containing protein 2B (HeLa tumor suppression 1) (Suppression of tumorigenicity 5 protein) | [Isoform 1]: May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane (PubMed:29030480). {ECO:0000269|PubMed:29030480, ECO:0000269|PubMed:9632734}.; FUNCTION: [Isoform 2]: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}.; FUNCTION: [Isoform 3]: May block ERK2 activation stimulated by ABL1 (Probable). May alter cell morphology and cell growth (Probable). {ECO:0000305|PubMed:10229203, ECO:0000305|PubMed:9632734}. |
| Q13228 | SELENBP1 | S243 | ochoa | Methanethiol oxidase (MTO) (EC 1.8.3.4) (56 kDa selenium-binding protein) (SBP56) (SP56) (Selenium-binding protein 1) | Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria (PubMed:29255262). Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport (By similarity). {ECO:0000250|UniProtKB:Q8VIF7, ECO:0000269|PubMed:29255262}. |
| Q13651 | IL10RA | Y496 | psp | Interleukin-10 receptor subunit alpha (IL-10 receptor subunit alpha) (IL-10R subunit alpha) (IL-10RA) (CDw210a) (Interleukin-10 receptor subunit 1) (IL-10R subunit 1) (IL-10R1) (CD antigen CD210) | Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well (PubMed:16982608). In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively associated with IL10RA and IL10RB respectively (PubMed:12133952). These kinases then phosphorylate specific tyrosine residues in the intracellular domain in IL10RA leading to the recruitment and subsequent phosphorylation of STAT3. Once phosphorylated, STAT3 homodimerizes, translocates to the nucleus and activates the expression of anti-inflammatory genes. In addition, IL10RA-mediated activation of STAT3 inhibits starvation-induced autophagy (PubMed:26962683). {ECO:0000269|PubMed:12133952, ECO:0000269|PubMed:16982608, ECO:0000269|PubMed:26962683}. |
| Q13671 | RIN1 | S461 | ochoa | Ras and Rab interactor 1 (Ras inhibitor JC99) (Ras interaction/interference protein 1) | Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis. {ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9208849}. |
| Q14005 | IL16 | S177 | ochoa | Pro-interleukin-16 [Cleaved into: Interleukin-16 (IL-16) (Lymphocyte chemoattractant factor) (LCF)] | Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.; FUNCTION: [Isoform 1]: May act as a scaffolding protein that anchors ion channels in the membrane.; FUNCTION: Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells. |
| Q14008 | CKAP5 | S247 | ochoa | Cytoskeleton-associated protein 5 (Colonic and hepatic tumor overexpressed gene protein) (Ch-TOG) | Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as a processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments (PubMed:27156448). {ECO:0000269|PubMed:12569123, ECO:0000269|PubMed:18809577, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:21646404, ECO:0000269|PubMed:23532825, ECO:0000269|PubMed:27156448, ECO:0000269|PubMed:9570755}. |
| Q14126 | DSG2 | S911 | ochoa | Desmoglein-2 (Cadherin family member 5) (HDGC) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:38395410). Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Required for proliferation and viability of embryonic stem cells in the blastocyst, thereby crucial for progression of post-implantation embryonic development (By similarity). Maintains pluripotency by regulating epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via interacting with and sequestering CTNNB1 to sites of cell-cell contact, thereby reducing translocation of CTNNB1 to the nucleus and subsequent transcription of CTNNB1/TCF-target genes (PubMed:29910125). Promotes pluripotency and the multi-lineage differentiation potential of hematopoietic stem cells (PubMed:27338829). Plays a role in endothelial cell sprouting and elongation via mediating the junctional-association of cortical actin fibers and CDH5 (PubMed:27338829). Plays a role in limiting inflammatory infiltration and the apoptotic response to injury in kidney tubular epithelial cells, potentially via its role in maintaining cell-cell adhesion and the epithelial barrier (PubMed:38395410). {ECO:0000250|UniProtKB:O55111, ECO:0000269|PubMed:27338829, ECO:0000269|PubMed:29910125, ECO:0000269|PubMed:38395410}. |
| Q14126 | DSG2 | S1068 | ochoa | Desmoglein-2 (Cadherin family member 5) (HDGC) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:38395410). Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Required for proliferation and viability of embryonic stem cells in the blastocyst, thereby crucial for progression of post-implantation embryonic development (By similarity). Maintains pluripotency by regulating epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via interacting with and sequestering CTNNB1 to sites of cell-cell contact, thereby reducing translocation of CTNNB1 to the nucleus and subsequent transcription of CTNNB1/TCF-target genes (PubMed:29910125). Promotes pluripotency and the multi-lineage differentiation potential of hematopoietic stem cells (PubMed:27338829). Plays a role in endothelial cell sprouting and elongation via mediating the junctional-association of cortical actin fibers and CDH5 (PubMed:27338829). Plays a role in limiting inflammatory infiltration and the apoptotic response to injury in kidney tubular epithelial cells, potentially via its role in maintaining cell-cell adhesion and the epithelial barrier (PubMed:38395410). {ECO:0000250|UniProtKB:O55111, ECO:0000269|PubMed:27338829, ECO:0000269|PubMed:29910125, ECO:0000269|PubMed:38395410}. |
| Q14674 | ESPL1 | S1508 | ochoa|psp | Separin (EC 3.4.22.49) (Caspase-like protein ESPL1) (Extra spindle poles-like 1 protein) (Separase) | Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms. {ECO:0000269|PubMed:10411507, ECO:0000269|PubMed:11509732}. |
| Q15036 | SNX17 | S312 | ochoa | Sorting nexin-17 | Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels (PubMed:15121882, PubMed:15769472, PubMed:39587083). Binds to NPxY sequences in the cytoplasmic tails of target cargos (PubMed:21512128). Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits (PubMed:22492727, PubMed:28892079, PubMed:39587083). Also required for maintenance of normal cell surface levels of APP and LRP1 (PubMed:16712798, PubMed:19005208). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (PubMed:16712798). {ECO:0000269|PubMed:15121882, ECO:0000269|PubMed:15769472, ECO:0000269|PubMed:16712798, ECO:0000269|PubMed:19005208, ECO:0000269|PubMed:21512128, ECO:0000269|PubMed:22492727, ECO:0000269|PubMed:28892079}. |
| Q15172 | PPP2R5A | S41 | ochoa|psp | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (PP2A B subunit isoform B'-alpha) (PP2A B subunit isoform B56-alpha) (PP2A B subunit isoform PR61-alpha) (PR61alpha) (PP2A B subunit isoform R5-alpha) | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. |
| Q15642 | TRIP10 | S477 | ochoa | Cdc42-interacting protein 4 (Protein Felic) (Salt tolerant protein) (hSTP) (Thyroid receptor-interacting protein 10) (TR-interacting protein 10) (TRIP-10) | Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL. {ECO:0000250, ECO:0000269|PubMed:11069762, ECO:0000269|PubMed:16318909, ECO:0000269|PubMed:16326391}. |
| Q15722 | LTB4R | S320 | ochoa|psp | Leukotriene B4 receptor 1 (LTB4-R 1) (LTB4-R1) (Chemoattractant receptor-like 1) (G-protein coupled receptor 16) (P2Y purinoceptor 7) (P2Y7) | Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response. |
| Q2KHT3 | CLEC16A | S864 | ochoa | Protein CLEC16A (C-type lectin domain family 16 member A) | Regulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PRKN pathway. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. The RNF41/NRDP1-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. May protect RNF41/NRDP1 from proteasomal degradation, RNF41/NRDP1 which regulates proteasomal degradation of PRKN. Plays a key role in beta cells functions by regulating mitophagy/autophagy and mitochondrial health. {ECO:0000269|PubMed:24949970}. |
| Q2M1Z3 | ARHGAP31 | S954 | ochoa | Rho GTPase-activating protein 31 (Cdc42 GTPase-activating protein) | Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading, polarized lamellipodia formation and cell migration. {ECO:0000269|PubMed:12192056, ECO:0000269|PubMed:16519628}. |
| Q53GL0 | PLEKHO1 | S227 | ochoa | Pleckstrin homology domain-containing family O member 1 (PH domain-containing family O member 1) (C-Jun-binding protein) (JBP) (Casein kinase 2-interacting protein 1) (CK2-interacting protein 1) (CKIP-1) (Osteoclast maturation-associated gene 120 protein) | Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation. {ECO:0000269|PubMed:14729969, ECO:0000269|PubMed:15706351, ECO:0000269|PubMed:15831458, ECO:0000269|PubMed:16325375, ECO:0000269|PubMed:16987810, ECO:0000269|PubMed:17197158, ECO:0000269|PubMed:17942896}. |
| Q53TQ3 | INO80D | S728 | ochoa | INO80 complex subunit D | Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. |
| Q5BKX6 | SLC45A4 | S389 | ochoa | Solute carrier family 45 member 4 | Proton-associated sucrose transporter. May be able to transport also glucose and fructose. {ECO:0000250|UniProtKB:Q0P5V9}. |
| Q5FWE3 | PRRT3 | S928 | ochoa | Proline-rich transmembrane protein 3 | None |
| Q5SYE7 | NHSL1 | S301 | ochoa | NHS-like protein 1 | None |
| Q5SYE7 | NHSL1 | S662 | ochoa | NHS-like protein 1 | None |
| Q5T1M5 | FKBP15 | S1024 | ochoa | FK506-binding protein 15 (FKBP-15) (133 kDa FK506-binding protein) (133 kDa FKBP) (FKBP-133) (WASP- and FKBP-like protein) (WAFL) | May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement. {ECO:0000250, ECO:0000269|PubMed:19121306}. |
| Q6AI08 | HEATR6 | S668 | ochoa | HEAT repeat-containing protein 6 (Amplified in breast cancer protein 1) | Amplification-dependent oncogene. |
| Q6P2C8 | MED27 | S132 | ochoa | Mediator of RNA polymerase II transcription subunit 27 (Cofactor required for Sp1 transcriptional activation subunit 8) (CRSP complex subunit 8) (Mediator complex subunit 27) (P37 TRAP/SMCC/PC2 subunit) (Transcriptional coactivator CRSP34) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:10882111, ECO:0000269|PubMed:9989412}. |
| Q6P9F7 | LRRC8B | S205 | ochoa | Volume-regulated anion channel subunit LRRC8B (Leucine-rich repeat-containing protein 8B) (T-cell activation leucine repeat-rich protein) (TA-LRRP) | Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24790029, PubMed:26824658, PubMed:28193731). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24790029, PubMed:26824658, PubMed:28193731). {ECO:0000269|PubMed:24790029, ECO:0000269|PubMed:26824658, ECO:0000269|PubMed:28193731}. |
| Q6UUV7 | CRTC3 | S62 | ochoa|psp | CREB-regulated transcription coactivator 3 (Transducer of regulated cAMP response element-binding protein 3) (TORC-3) (Transducer of CREB protein 3) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:15466468, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223, ECO:0000269|PubMed:17644518}. |
| Q6ZRV2 | FAM83H | S1003 | ochoa | Protein FAM83H | May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:18252228, ECO:0000269|PubMed:23902688}. |
| Q7Z2K8 | GPRIN1 | S862 | ochoa | G protein-regulated inducer of neurite outgrowth 1 (GRIN1) | May be involved in neurite outgrowth. {ECO:0000250}. |
| Q7Z3K3 | POGZ | S410 | ochoa | Pogo transposable element with ZNF domain (Suppressor of hairy wing homolog 5) (Zinc finger protein 280E) (Zinc finger protein 635) | Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms (PubMed:20562864). Promotes the repair of DNA double-strand breaks through the homologous recombination pathway (PubMed:26721387). {ECO:0000269|PubMed:20562864, ECO:0000269|PubMed:26721387}. |
| Q7Z6B7 | SRGAP1 | S917 | ochoa | SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho GTPase-activating protein 13) | GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42. {ECO:0000269|PubMed:11672528}. |
| Q7Z6I6 | ARHGAP30 | S994 | ochoa | Rho GTPase-activating protein 30 (Rho-type GTPase-activating protein 30) | GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. {ECO:0000269|PubMed:21565175}. |
| Q86XP3 | DDX42 | S715 | ochoa | ATP-dependent RNA helicase DDX42 (EC 3.6.4.13) (DEAD box protein 42) (RNA helicase-like protein) (RHELP) (RNA helicase-related protein) (RNAHP) (SF3b DEAD box protein) (Splicing factor 3B-associated 125 kDa protein) (SF3b125) | ATP-dependent RNA helicase that binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures (PubMed:16397294). Unwinding is promoted in the presence of single-strand binding proteins (PubMed:16397294). Also mediates RNA duplex formation thereby displacing the single-strand RNA binding protein (PubMed:16397294). ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands (PubMed:16397294). Required for assembly of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs: DDX42 associates transiently with the SF3B subcomplex of the 17S U2 SnRNP complex and is released after fulfilling its role in the assembly of 17S U2 SnRNP (PubMed:12234937, PubMed:36797247). Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2 (PubMed:19377511). Relocalizes TP53BP2 to the cytoplasm (PubMed:19377511). {ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:16397294, ECO:0000269|PubMed:19377511, ECO:0000269|PubMed:36797247}. |
| Q8IV53 | DENND1C | S582 | ochoa | DENN domain-containing protein 1C (Connecdenn 3) (Protein FAM31C) | Guanine nucleotide exchange factor (GEF) which may activate RAB8A, RAB13 and RAB35. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20154091, ECO:0000269|PubMed:20937701}. |
| Q8IVD9 | NUDCD3 | S340 | ochoa | NudC domain-containing protein 3 | None |
| Q8IWA4 | MFN1 | S86 | psp | Mitofusin-1 (EC 3.6.5.-) (Fzo homolog) (Transmembrane GTPase MFN1) | Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:12475957, PubMed:12759376, PubMed:27920125, PubMed:28114303). Membrane clustering requires GTPase activity (PubMed:27920125). It may involve a major rearrangement of the coiled coil domains (PubMed:27920125, PubMed:28114303). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:12475957, PubMed:12759376). Overexpression induces the formation of mitochondrial networks (in vitro) (PubMed:12759376). Has low GTPase activity (PubMed:27920125, PubMed:28114303). {ECO:0000269|PubMed:12475957, ECO:0000269|PubMed:12759376, ECO:0000269|PubMed:27920125, ECO:0000269|PubMed:28114303}. |
| Q8IZW8 | TNS4 | S200 | ochoa | Tensin-4 (C-terminal tensin-like protein) | Promotes EGF-induced cell migration by displacing tensin TNS3 from the cytoplasmic tail of integrin ITGB1 which results in dissociation of TNS3 from focal adhesions, disassembly of actin stress fibers and initiation of cell migration (PubMed:17643115). Suppresses ligand-induced degradation of EGFR by reducing EGFR ubiquitination in the presence of EGF (PubMed:23774213). Increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation which leads to increased cell survival, proliferation and migration (PubMed:24814316). {ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:23774213, ECO:0000269|PubMed:24814316}. |
| Q8N264 | ARHGAP24 | S437 | psp | Rho GTPase-activating protein 24 (Filamin-A-associated RhoGAP) (FilGAP) (RAC1- and CDC42-specific GTPase-activating protein of 72 kDa) (RC-GAP72) (Rho-type GTPase-activating protein 24) (RhoGAP of 73 kDa) (Sarcoma antigen NY-SAR-88) (p73RhoGAP) | Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis. {ECO:0000269|PubMed:15302923, ECO:0000269|PubMed:15611138, ECO:0000269|PubMed:16862148}. |
| Q8N3S3 | PHTF2 | S221 | ochoa | Protein PHTF2 | None |
| Q8TDM6 | DLG5 | S932 | ochoa | Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG) | Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). {ECO:0000250|UniProtKB:E9Q9R9, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:28169360}. |
| Q8TEV9 | SMCR8 | S638 | ochoa | Guanine nucleotide exchange protein SMCR8 (Smith-Magenis syndrome chromosomal region candidate gene 8 protein) | Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:20562859, PubMed:27103069, PubMed:27193190, PubMed:27559131, PubMed:27617292, PubMed:28195531, PubMed:32303654). In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:20562859, PubMed:27103069, PubMed:27617292, PubMed:28195531). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity (PubMed:27617292, PubMed:28195531). As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro (PubMed:32303654). Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates (PubMed:27559131, PubMed:28195531). In addition to its activity in the cytoplasm within the C9orf72-SMCR8 complex, SMCR8 also localizes in the nucleus, where it associates with chromatin and negatively regulates expression of suppresses ULK1 and WIPI2 genes (PubMed:28195531). {ECO:0000269|PubMed:20562859, ECO:0000269|PubMed:27103069, ECO:0000269|PubMed:27193190, ECO:0000269|PubMed:27559131, ECO:0000269|PubMed:27617292, ECO:0000269|PubMed:28195531, ECO:0000269|PubMed:32303654}. |
| Q8WUI4 | HDAC7 | S464 | ochoa | Histone deacetylase 7 (HD7) (EC 3.5.1.98) (Histone deacetylase 7A) (HD7a) (Protein deacetylase HDAC7) (EC 3.5.1.-) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C (By similarity). During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene (PubMed:12239305). Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565). Serves as a corepressor of RARA, causing its deacetylation and inhibition of RARE DNA element binding (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758). Also acetylates non-histone proteins, such as ALKBH5 (PubMed:37369679). {ECO:0000250|UniProtKB:Q8C2B3, ECO:0000269|PubMed:12239305, ECO:0000269|PubMed:17360565, ECO:0000269|PubMed:28167758, ECO:0000269|PubMed:37369679}. |
| Q8WVM7 | STAG1 | S1093 | ochoa | Cohesin subunit SA-1 (SCC3 homolog 1) (Stromal antigen 1) | Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. |
| Q92667 | AKAP1 | S586 | ochoa | A-kinase anchor protein 1, mitochondrial (A-kinase anchor protein 149 kDa) (AKAP 149) (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Protein kinase A-anchoring protein 1) (PRKA1) (Spermatid A-kinase anchor protein 84) (S-AKAP84) | Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane (By similarity). Involved in mitochondrial-mediated antiviral innate immunity (PubMed:31522117). Promotes translocation of NDUFS1 into mitochondria to regulate mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) activity (By similarity). {ECO:0000250|UniProtKB:O08715, ECO:0000269|PubMed:31522117}. |
| Q96AD5 | PNPLA2 | S404 | ochoa | Patatin-like phospholipase domain-containing protein 2 (EC 3.1.1.3) (Adipose triglyceride lipase) (Calcium-independent phospholipase A2-zeta) (iPLA2-zeta) (EC 3.1.1.4) (Desnutrin) (Pigment epithelium-derived factor receptor) (PEDF-R) (TTS2.2) (Transport-secretion protein 2) (TTS2) | Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets (PubMed:15364929, PubMed:15550674, PubMed:16150821, PubMed:16239926, PubMed:17603008, PubMed:34903883). Exhibits a strong preference for the hydrolysis of long-chain fatty acid esters at the sn-2 position of the glycerol backbone and acts coordinately with LIPE/HLS and DGAT2 within the lipolytic cascade (By similarity). Also possesses acylglycerol transacylase and phospholipase A2 activities (PubMed:15364929, PubMed:17032652, PubMed:17603008). Transfers fatty acid from triglyceride to retinol, hydrolyzes retinylesters, and generates 1,3-diacylglycerol from triglycerides (PubMed:17603008). Regulates adiposome size and may be involved in the degradation of adiposomes (PubMed:16239926). Catalyzes the formation of an ester bond between hydroxy fatty acids and fatty acids derived from triglycerides or diglycerides to generate fatty acid esters of hydroxy fatty acids (FAHFAs) in adipocytes (PubMed:35676490). Acts antagonistically with LDAH in regulation of cellular lipid stores (PubMed:28578400). Inhibits LDAH-stimulated lipid droplet fusion (PubMed:28578400). May play an important role in energy homeostasis (By similarity). May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion (By similarity). {ECO:0000250|UniProtKB:Q8BJ56, ECO:0000269|PubMed:15364929, ECO:0000269|PubMed:15550674, ECO:0000269|PubMed:16150821, ECO:0000269|PubMed:16239926, ECO:0000269|PubMed:17032652, ECO:0000269|PubMed:17603008, ECO:0000269|PubMed:28578400, ECO:0000269|PubMed:34903883, ECO:0000269|PubMed:35676490}. |
| Q96C01 | FAM136A | S19 | ochoa | Protein FAM136A | None |
| Q96JT2 | SLC45A3 | S426 | ochoa | Solute carrier family 45 member 3 (Prostate cancer-associated protein 6) (Prostein) | Proton-associated sucrose transporter. May be able to transport also glucose and fructose. {ECO:0000250|UniProtKB:Q8K0H7}. |
| Q96R06 | SPAG5 | S362 | ochoa | Sperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126) | Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase (PubMed:11724960, PubMed:12356910, PubMed:27462074). Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:17664331, PubMed:27462074). In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes (PubMed:18361916, PubMed:21402792). Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis (PubMed:23953116). May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU (PubMed:18055457). {ECO:0000269|PubMed:12356910, ECO:0000269|PubMed:17664331, ECO:0000269|PubMed:18055457, ECO:0000269|PubMed:18361916, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:23953116, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:27462074, ECO:0000305|PubMed:11724960}. |
| Q96RG2 | PASK | S1287 | ochoa | PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (hPASK) (EC 2.7.11.1) | Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation. {ECO:0000269|PubMed:16275910, ECO:0000269|PubMed:17052199, ECO:0000269|PubMed:17595531, ECO:0000269|PubMed:20943661, ECO:0000269|PubMed:21181396, ECO:0000269|PubMed:21418524}. |
| Q96RR4 | CAMKK2 | S114 | ochoa | Calcium/calmodulin-dependent protein kinase kinase 2 (CaM-KK 2) (CaM-kinase kinase 2) (CaMKK 2) (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-KK beta) (CaM-kinase kinase beta) (CaMKK beta) | Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching. {ECO:0000250, ECO:0000269|PubMed:11395482, ECO:0000269|PubMed:12935886, ECO:0000269|PubMed:21957496, ECO:0000269|PubMed:9662074}. |
| Q96RS0 | TGS1 | S445 | ochoa | Trimethylguanosine synthase (EC 2.1.1.-) (CLL-associated antigen KW-2) (Cap-specific guanine-N(2) methyltransferase) (Hepatocellular carcinoma-associated antigen 137) (Nuclear receptor coactivator 6-interacting protein) (PRIP-interacting protein with methyltransferase motif) (PIMT) (PIPMT) | Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation. {ECO:0000269|PubMed:11517327, ECO:0000269|PubMed:11912212, ECO:0000269|PubMed:16687569, ECO:0000269|PubMed:18775984}. |
| Q96SD1 | DCLRE1C | S503 | psp | Protein artemis (EC 3.1.-.-) (DNA cross-link repair 1C protein) (Protein A-SCID) (SNM1 homolog C) (hSNM1C) (SNM1-like protein) | Nuclease involved in DNA non-homologous end joining (NHEJ); required for double-strand break repair and V(D)J recombination (PubMed:11336668, PubMed:11955432, PubMed:12055248, PubMed:14744996, PubMed:15071507, PubMed:15574326, PubMed:15936993). Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments (PubMed:11336668, PubMed:11955432, PubMed:14744996). V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs) (PubMed:11336668, PubMed:11955432, PubMed:14744996). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends (PubMed:11336668, PubMed:11955432, PubMed:14744996). These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively (PubMed:11336668, PubMed:11955432, PubMed:14744996). This protein exhibits single-strand specific 5'-3' exonuclease activity in isolation and acquires endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC (PubMed:11955432, PubMed:15071507, PubMed:15574326, PubMed:15936993). The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint (PubMed:11955432). Also required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ (PubMed:15456891, PubMed:15468306, PubMed:15574327, PubMed:15811628). {ECO:0000269|PubMed:11336668, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12055248, ECO:0000269|PubMed:14744996, ECO:0000269|PubMed:15071507, ECO:0000269|PubMed:15456891, ECO:0000269|PubMed:15468306, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:15574327, ECO:0000269|PubMed:15811628, ECO:0000269|PubMed:15936993}. |
| Q99704 | DOK1 | S269 | ochoa | Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62) | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3. {ECO:0000269|PubMed:18156175}. |
| Q9BQA1 | WDR77 | S48 | ochoa | Methylosome protein WDR77 (Androgen receptor cofactor p44) (Methylosome protein 50) (MEP-50) (WD repeat-containing protein 77) (p44/Mep50) | Non-catalytic component of the methylosome complex, composed of PRMT5, WDR77 and CLNS1A, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones (PubMed:11756452). This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The methylosome complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (PubMed:23071334). {ECO:0000269|PubMed:11756452, ECO:0000269|PubMed:23071334}. |
| Q9BWH6 | RPAP1 | S266 | ochoa | RNA polymerase II-associated protein 1 | Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Required for interaction of the RNA polymerase II complex with acetylated histone H3. {ECO:0000269|PubMed:17643375}. |
| Q9BYG4 | PARD6G | S110 | ochoa | Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6D) | Adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (By similarity). {ECO:0000250}. |
| Q9BZ67 | FRMD8 | S418 | ochoa | FERM domain-containing protein 8 (Band4.1 inhibitor LRP interactor) (Bili) (iRhom tail-associated protein) (iTAP) | Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface (PubMed:29897333, PubMed:29897336). Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6 (PubMed:19572019). {ECO:0000269|PubMed:19572019, ECO:0000269|PubMed:29897333, ECO:0000269|PubMed:29897336}. |
| Q9GZY8 | MFF | S179 | ochoa | Mitochondrial fission factor | Plays a role in mitochondrial and peroxisomal fission (PubMed:18353969, PubMed:23530241, PubMed:24196833). Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface (PubMed:23530241). May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles (By similarity). {ECO:0000250|UniProtKB:Q4KM98, ECO:0000269|PubMed:18353969, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:24196833}. |
| Q9H7N4 | SCAF1 | S1136 | ochoa | Splicing factor, arginine/serine-rich 19 (SR-related C-terminal domain-associated factor 1) (SR-related and CTD-associated factor 1) (SR-related-CTD-associated factor) (SCAF) (Serine arginine-rich pre-mRNA splicing factor SR-A1) (SR-A1) | May function in pre-mRNA splicing. {ECO:0000250}. |
| Q9H7Z7 | PTGES2 | S95 | ochoa | Prostaglandin E synthase 2 (EC 5.3.99.3) (Membrane-associated prostaglandin E synthase-2) (mPGE synthase-2) (Microsomal prostaglandin E synthase 2) (mPGES-2) (Prostaglandin-H(2) E-isomerase) [Cleaved into: Prostaglandin E synthase 2 truncated form] | Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2) (in vitro) (PubMed:12804604, PubMed:17585783, PubMed:18198127). The biological function and the GSH-dependent property of PTGES2 is still under debate (PubMed:17585783, PubMed:18198127). In vivo, PTGES2 could form a complex with GSH and heme and would not participate in PGE2 synthesis but would catalyze the degradation of prostaglandin E2 H2 (PGH2) to 12(S)-hydroxy-5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA) (By similarity) (PubMed:17585783). {ECO:0000250|UniProtKB:Q9N0A4, ECO:0000269|PubMed:12804604, ECO:0000269|PubMed:17585783, ECO:0000269|PubMed:18198127}. |
| Q9HAW4 | CLSPN | S833 | ochoa | Claspin (hClaspin) | Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation (PubMed:12766152, PubMed:15190204, PubMed:15707391, PubMed:16123041). Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins (PubMed:12766152, PubMed:15096610, PubMed:15707391, PubMed:16123041). Also required to maintain normal rates of replication fork progression during unperturbed DNA replication. Binds directly to DNA, with particular affinity for branched or forked molecules and interacts with multiple protein components of the replisome such as the MCM2-7 complex and TIMELESS (PubMed:15226314, PubMed:34694004, PubMed:35585232). Important for initiation of DNA replication, recruits kinase CDC7 to phosphorylate MCM2-7 components (PubMed:27401717). {ECO:0000269|PubMed:12766152, ECO:0000269|PubMed:15096610, ECO:0000269|PubMed:15190204, ECO:0000269|PubMed:15226314, ECO:0000269|PubMed:15707391, ECO:0000269|PubMed:16123041, ECO:0000269|PubMed:27401717, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:35585232}. |
| Q9HBD1 | RC3H2 | S549 | ochoa | Roquin-2 (EC 2.3.2.27) (Membrane-associated nucleic acid-binding protein) (RING finger and CCCH-type zinc finger domain-containing protein 2) (RING finger protein 164) (RING-type E3 ubiquitin transferase Roquin-2) | Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression. Also recognizes CDE in its own mRNA and in that of paralogous RC3H1, possibly leading to feedback loop regulation (By similarity). miRNA-binding protein that regulates microRNA homeostasis. Enhances DICER-mediated processing of pre-MIR146a but reduces mature MIR146a levels through an increase of 3' end uridylation. Both inhibits ICOS mRNA expression and they may act together to exert the suppression (PubMed:25697406). Acts as a ubiquitin E3 ligase. Pairs with E2 enzymes UBE2B, UBE2D2, UBE2E2, UBE2E3, UBE2G2, UBE2K and UBE2Q2 and produces polyubiquitin chains (PubMed:26489670). Shows the strongest activity when paired with UBE2N:UBE2V1 or UBE2N:UBE2V2 E2 complexes and generate both short and long polyubiquitin chains (PubMed:26489670). Involved in the ubiquitination of MAP3K5 (PubMed:24448648, PubMed:26489670, PubMed:29186683). Able to interact with double-stranded RNA (dsRNA) (PubMed:26489670). {ECO:0000250|UniProtKB:P0C090, ECO:0000269|PubMed:24448648, ECO:0000269|PubMed:26489670, ECO:0000269|PubMed:29186683}. |
| Q9NQR4 | NIT2 | S26 | ochoa | Omega-amidase NIT2 (EC 3.5.1.3) (Nitrilase homolog 2) | Has omega-amidase activity (PubMed:19595734, PubMed:22674578). The role of omega-amidase is to remove potentially toxic intermediates by converting 2-oxoglutaramate and 2-oxosuccinamate to biologically useful 2-oxoglutarate and oxaloacetate, respectively (PubMed:19595734). {ECO:0000269|PubMed:19595734, ECO:0000269|PubMed:22674578}. |
| Q9NZH0 | GPRC5B | S354 | ochoa | G-protein coupled receptor family C group 5 member B (A-69G12.1) (Retinoic acid-induced gene 2 protein) (RAIG-2) | G-protein coupled receptor involved in the regulation of cell volume. {ECO:0000269|PubMed:37143309}. |
| Q9P273 | TENM3 | S202 | ochoa | Teneurin-3 (Ten-3) (Protein Odd Oz/ten-m homolog 3) (Tenascin-M3) (Ten-m3) (Teneurin transmembrane protein 3) | Involved in neural development by regulating the establishment of proper connectivity within the nervous system. Acts in both pre- and postsynaptic neurons in the hippocampus to control the assembly of a precise topographic projection: required in both CA1 and subicular neurons for the precise targeting of proximal CA1 axons to distal subiculum, probably by promoting homophilic cell adhesion. Required for proper dendrite morphogenesis and axon targeting in the vertebrate visual system, thereby playing a key role in the development of the visual pathway. Regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). May also be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes. {ECO:0000250|UniProtKB:Q9WTS6}. |
| Q9P273 | TENM3 | S207 | ochoa | Teneurin-3 (Ten-3) (Protein Odd Oz/ten-m homolog 3) (Tenascin-M3) (Ten-m3) (Teneurin transmembrane protein 3) | Involved in neural development by regulating the establishment of proper connectivity within the nervous system. Acts in both pre- and postsynaptic neurons in the hippocampus to control the assembly of a precise topographic projection: required in both CA1 and subicular neurons for the precise targeting of proximal CA1 axons to distal subiculum, probably by promoting homophilic cell adhesion. Required for proper dendrite morphogenesis and axon targeting in the vertebrate visual system, thereby playing a key role in the development of the visual pathway. Regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). May also be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes. {ECO:0000250|UniProtKB:Q9WTS6}. |
| Q9P2G1 | ANKIB1 | S884 | ochoa | Ankyrin repeat and IBR domain-containing protein 1 (EC 2.3.2.31) | Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates. {ECO:0000250}. |
| Q9P2H5 | USP35 | S613 | ochoa|psp | Ubiquitin carboxyl-terminal hydrolase 35 (EC 3.4.19.12) (Deubiquitinating enzyme 35) (Ubiquitin thioesterase 35) (Ubiquitin-specific-processing protease 35) | Deubiquitinase that plays a role in different processes including cell cycle regulation, mitophagy or endoplasmic reticulum stress (PubMed:26348204, PubMed:29449677, PubMed:37004621). Inhibits TNFalpha-induced NF-kappa-B activation through stabilizing TNIP2 protein via deubiquitination (PubMed:26348204). Plays an essential role during mitosis by deubiquitinating and thereby regulating the levels of Aurora B/AURKB protein (PubMed:29449677). In addition, regulates the protein levels of other key component of the chromosomal passenger complex (CPC) such as survivin/BIRC5 or Borealin/CDCA8 by enhancing their stability (PubMed:34438346). Regulates the degradation of mitochondria through the process of autophagy termed mitophagy (PubMed:25915564). {ECO:0000269|PubMed:25915564, ECO:0000269|PubMed:26348204, ECO:0000269|PubMed:29449677, ECO:0000269|PubMed:34438346, ECO:0000269|PubMed:37004621}. |
| Q9UGH3 | SLC23A2 | S81 | ochoa | Solute carrier family 23 member 2 (Na(+)/L-ascorbic acid transporter 2) (Nucleobase transporter-like 1 protein) (Sodium-dependent vitamin C transporter 2) (hSVCT2) (Yolk sac permease-like molecule 2) | Sodium/ascorbate cotransporter (PubMed:10471399, PubMed:10556521). Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate (PubMed:10471399). {ECO:0000269|PubMed:10471399, ECO:0000269|PubMed:10556521}. |
| Q9UGP4 | LIMD1 | S243 | ochoa | LIM domain-containing protein 1 | Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation. {ECO:0000269|PubMed:15542589, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22286099}. |
| Q9UGU0 | TCF20 | S1482 | ochoa | Transcription factor 20 (TCF-20) (Nuclear factor SPBP) (Protein AR1) (Stromelysin-1 PDGF-responsive element-binding protein) (SPRE-binding protein) | Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator. {ECO:0000269|PubMed:10995766}. |
| Q9UN36 | NDRG2 | S326 | ochoa | Protein NDRG2 (N-myc downstream-regulated gene 2 protein) (Protein Syld709613) | Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation. {ECO:0000269|PubMed:12845671, ECO:0000269|PubMed:16103061, ECO:0000269|PubMed:21247902}. |
| Q9UQ26 | RIMS2 | S513 | ochoa | Regulating synaptic membrane exocytosis protein 2 (Rab-3-interacting molecule 2) (RIM 2) (Rab-3-interacting protein 3) | Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000269|PubMed:23999003}. |
| Q9Y272 | RASD1 | S232 | ochoa | Dexamethasone-induced Ras-related protein 1 (Activator of G-protein signaling 1) | Small GTPase. Negatively regulates the transcription regulation activity of the APBB1/FE65-APP complex via its interaction with APBB1/FE65 (By similarity). {ECO:0000250}. |
| Q9Y2L6 | FRMD4B | S694 | ochoa | FERM domain-containing protein 4B (GRP1-binding protein GRSP1) | Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex. Plays a redundant role with FRMD4A in epithelial polarization. {ECO:0000250|UniProtKB:Q920B0}. |
| Q9Y2Y9 | KLF13 | S268 | ochoa | Krueppel-like factor 13 (Basic transcription element-binding protein 3) (BTE-binding protein 3) (Novel Sp1-like zinc finger transcription factor 1) (RANTES factor of late activated T-lymphocytes 1) (RFLAT-1) (Transcription factor BTEB3) (Transcription factor NSLP1) | Transcription factor that activates expression from GC-rich minimal promoter regions, including genes in the cells of the erythroid lineage (By similarity). Represses transcription by binding to the BTE site, a GC-rich DNA element, in competition with the activator SP1. It also represses transcription by interacting with the corepressor Sin3A and HDAC1 (PubMed:11477107). Activates RANTES and CCL5 expression in T-cells (PubMed:17513757). {ECO:0000250|UniProtKB:Q9JJZ6, ECO:0000269|PubMed:11477107, ECO:0000269|PubMed:17513757}. |
| Q9Y3R0 | GRIP1 | S1097 | ochoa | Glutamate receptor-interacting protein 1 (GRIP-1) | May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons (PubMed:10197531). Through complex formation with NSG1, GRIA2 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity). {ECO:0000250|UniProtKB:P97879, ECO:0000269|PubMed:10197531}. |
| Q9Y490 | TLN1 | S1503 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| Q9Y4B6 | DCAF1 | S1328 | ochoa | DDB1- and CUL4-associated factor 1 (HIV-1 Vpr-binding protein) (VprBP) (Serine/threonine-protein kinase VPRBP) (EC 2.7.11.1) (Vpr-interacting protein) | Acts both as a substrate recognition component of E3 ubiquitin-protein ligase complexes and as an atypical serine/threonine-protein kinase, playing key roles in various processes such as cell cycle, telomerase regulation and histone modification. Probable substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, named CUL4A-RBX1-DDB1-DCAF1/VPRBP complex, which mediates ubiquitination and proteasome-dependent degradation of proteins such as NF2 (PubMed:23063525). Involved in the turnover of methylated proteins: recognizes and binds methylated proteins via its chromo domain, leading to ubiquitination of target proteins by the RBX1-DDB1-DCAF1/VPRBP complex (PubMed:23063525). The CUL4A-RBX1-DDB1-DCAF1/VPRBP complex is also involved in B-cell development: DCAF1 is recruited by RAG1 to ubiquitinate proteins, leading to limit error-prone repair during V(D)J recombination (By similarity). Also part of the EDVP complex, an E3 ligase complex that mediates ubiquitination of proteins such as TERT, leading to TERT degradation and telomerase inhibition (PubMed:19287380, PubMed:23362280). The EDVP complex also mediates ubiquitination and degradation of CCP110 (PubMed:28242748, PubMed:34259627). Also acts as an atypical serine/threonine-protein kinase that specifically mediates phosphorylation of 'Thr-120' of histone H2A (H2AT120ph) in a nucleosomal context, thereby repressing transcription (PubMed:24140421). H2AT120ph is present in the regulatory region of many tumor suppresor genes, down-regulates their transcription and is present at high level in a number of tumors (PubMed:24140421). Involved in JNK-mediated apoptosis during cell competition process via its interaction with LLGL1 and LLGL2 (PubMed:20644714). By acting on TET dioxygenses, essential for oocyte maintenance at the primordial follicle stage, hence essential for female fertility (By similarity). {ECO:0000250|UniProtKB:Q80TR8, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:17609381, ECO:0000269|PubMed:17630831, ECO:0000269|PubMed:18332868, ECO:0000269|PubMed:18524771, ECO:0000269|PubMed:18606781, ECO:0000269|PubMed:19287380, ECO:0000269|PubMed:20644714, ECO:0000269|PubMed:22184063, ECO:0000269|PubMed:23063525, ECO:0000269|PubMed:23362280, ECO:0000269|PubMed:24140421, ECO:0000269|PubMed:28242748, ECO:0000269|PubMed:34259627}.; FUNCTION: (Microbial infection) In case of infection by HIV-1 virus, it is recruited by HIV-1 Vpr in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to arrest the cell cycle in G2 phase, and also to protect the viral protein from proteasomal degradation by another E3 ubiquitin ligase. The HIV-1 Vpr protein hijacks the CUL4A-RBX1-DDB1-DCAF1/VPRBP complex to promote ubiquitination and degradation of proteins such as TERT and ZIP/ZGPAT. {ECO:0000269|PubMed:17314515, ECO:0000269|PubMed:17559673, ECO:0000269|PubMed:17609381, ECO:0000269|PubMed:17620334, ECO:0000269|PubMed:17626091, ECO:0000269|PubMed:17630831, ECO:0000269|PubMed:18524771, ECO:0000269|PubMed:24116224}.; FUNCTION: (Microbial infection) In case of infection by HIV-2 virus, it is recruited by HIV-2 Vpx in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to enhanced efficiency of macrophage infection and promotion of the replication of cognate primate lentiviruses in cells of monocyte/macrophage lineage. {ECO:0000269|PubMed:17314515, ECO:0000269|PubMed:18464893, ECO:0000269|PubMed:19264781, ECO:0000269|PubMed:19923175, ECO:0000269|PubMed:24336198}. |
| Q9Y4F5 | CEP170B | S1040 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
| Q9Y4L1 | HYOU1 | S461 | ochoa | Hypoxia up-regulated protein 1 (150 kDa oxygen-regulated protein) (ORP-150) (170 kDa glucose-regulated protein) (GRP-170) (Heat shock protein family H member 4) | Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. Promotes HSPA5/BiP-mediated ATP nucleotide exchange and thereby activates the unfolded protein response (UPR) pathway in the presence of endoplasmic reticulum stress (By similarity). May play a role as a molecular chaperone and participate in protein folding. {ECO:0000250|UniProtKB:Q9JKR6, ECO:0000269|PubMed:10037731}. |
| Q9Y6J0 | CABIN1 | S433 | ochoa | Calcineurin-binding protein cabin-1 (Calcineurin inhibitor) (CAIN) | May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:9655484}. |
| P37108 | SRP14 | S25 | Sugiyama | Signal recognition particle 14 kDa protein (SRP14) (18 kDa Alu RNA-binding protein) | Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:11089964). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP (PubMed:11089964). The complex of SRP9 and SRP14 is required for SRP RNA binding (PubMed:11089964). {ECO:0000269|PubMed:11089964}. |
| Q8NBJ7 | SUMF2 | S281 | Sugiyama | Inactive C-alpha-formylglycine-generating enzyme 2 (Paralog of formylglycine-generating enzyme) (pFGE) (Sulfatase-modifying factor 2) | Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1. {ECO:0000269|PubMed:12757706, ECO:0000269|PubMed:15708861, ECO:0000269|PubMed:15962010}. |
| P11047 | LAMC1 | S942 | Sugiyama | Laminin subunit gamma-1 (Laminin B2 chain) (Laminin-1 subunit gamma) (Laminin-10 subunit gamma) (Laminin-11 subunit gamma) (Laminin-2 subunit gamma) (Laminin-3 subunit gamma) (Laminin-4 subunit gamma) (Laminin-6 subunit gamma) (Laminin-7 subunit gamma) (Laminin-8 subunit gamma) (Laminin-9 subunit gamma) (S-laminin subunit gamma) (S-LAM gamma) | Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. |
| O15111 | CHUK | S559 | Sugiyama | Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16) | Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues (PubMed:18626576, PubMed:35952808, PubMed:9244310, PubMed:9252186, PubMed:9346484). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11) (PubMed:21765415). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes (PubMed:20501937). In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis. Also participates in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilizing MAP3K14/NIK. Within the nucleus, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities (PubMed:17434128). Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at 'Ser-10' that are subsequently acetylated at 'Lys-14' by CREBBP (PubMed:12789342). Additionally, phosphorylates the CREBBP-interacting protein NCOA3. Also phosphorylates FOXO3 and may regulate this pro-apoptotic transcription factor (PubMed:15084260). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates AMBRA1 following mitophagy induction, promoting AMBRA1 interaction with ATG8 family proteins and its mitophagic activity (PubMed:30217973). {ECO:0000250|UniProtKB:Q60680, ECO:0000269|PubMed:12789342, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17434128, ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20501937, ECO:0000269|PubMed:21765415, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35952808, ECO:0000269|PubMed:9244310, ECO:0000269|PubMed:9252186, ECO:0000269|PubMed:9346484, ECO:0000303|PubMed:18626576}. |
| O60566 | BUB1B | S318 | Sugiyama | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1) | Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. {ECO:0000269|PubMed:10477750, ECO:0000269|PubMed:11702782, ECO:0000269|PubMed:14706340, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:19411850, ECO:0000269|PubMed:19503101}. |
| Q9UBR2 | CTSZ | S195 | Sugiyama | Cathepsin Z (EC 3.4.18.1) (Cathepsin P) (Cathepsin X) | Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity (PubMed:10504234). Capable of producing kinin potentiating peptides (By similarity). {ECO:0000250|UniProtKB:Q9R1T3, ECO:0000269|PubMed:10504234}. |
| P10415 | BCL2 | S24 | iPTMNet|EPSD | Apoptosis regulator Bcl-2 | Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells (PubMed:1508712, PubMed:8183370). Regulates cell death by controlling the mitochondrial membrane permeability (PubMed:11368354). Appears to function in a feedback loop system with caspases (PubMed:11368354). Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (PubMed:11368354). Also acts as an inhibitor of autophagy: interacts with BECN1 and AMBRA1 during non-starvation conditions and inhibits their autophagy function (PubMed:18570871, PubMed:20889974, PubMed:21358617). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785). {ECO:0000269|PubMed:1508712, ECO:0000269|PubMed:17418785, ECO:0000269|PubMed:18570871, ECO:0000269|PubMed:20889974, ECO:0000269|PubMed:21358617, ECO:0000269|PubMed:8183370, ECO:0000303|PubMed:11368354}. |
| P35368 | ADRA1B | S396 | SIGNOR|iPTMNet|EPSD | Alpha-1B adrenergic receptor (Alpha-1B adrenoreceptor) (Alpha-1B adrenoceptor) | This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes. {ECO:0000269|PubMed:18802028, ECO:0000269|PubMed:22120526}. |
| P35368 | ADRA1B | S406 | SIGNOR|iPTMNet|EPSD | Alpha-1B adrenergic receptor (Alpha-1B adrenoreceptor) (Alpha-1B adrenoceptor) | This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes. {ECO:0000269|PubMed:18802028, ECO:0000269|PubMed:22120526}. |
| Q14957 | GRIN2C | S1081 | SIGNOR | Glutamate receptor ionotropic, NMDA 2C (GluN2C) (Glutamate [NMDA] receptor subunit epsilon-3) (N-methyl D-aspartate receptor subtype 2C) (NMDAR2C) (NR2C) | Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:26875626, PubMed:36309015). Participates in synaptic plasticity for learning and memory formation by contributing to the slow phase of excitatory postsynaptic current and long-term synaptic potentiation (By similarity). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:26875626, PubMed:36309015). NMDARs mediate simultaneously the potasium efflux and the influx of calcium and sodium (By similarity). Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (PubMed:26875626). {ECO:0000250|UniProtKB:P35438, ECO:0000250|UniProtKB:Q01098, ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:36309015}. |
| P53992 | SEC24C | S378 | Sugiyama | Protein transport protein Sec24C (SEC24-related protein C) | Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:10214955, PubMed:17499046, PubMed:18843296, PubMed:20427317). Plays a central role in cargo selection within the COPII complex and together with SEC24D may have a different specificity compared to SEC24A and SEC24B (PubMed:17499046, PubMed:18843296, PubMed:20427317). May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed:20427317). May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed:18843296). {ECO:0000269|PubMed:10214955, ECO:0000269|PubMed:17499046, ECO:0000269|PubMed:18843296, ECO:0000269|PubMed:20427317}. |
| P52209 | PGD | S405 | Sugiyama | 6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44) | Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. {ECO:0000250}. |
| Q9H2X6 | HIPK2 | S955 | Sugiyama | Homeodomain-interacting protein kinase 2 (hHIPk2) (EC 2.7.11.1) | Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1, ZBTB4 and DAZAP2. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect acetylation). The phosphorylation of p53/TP53 may be mediated by a p53/TP53-HIPK2-AXIN1 complex. Involved in the response to hypoxia by acting as a transcriptional co-suppressor of HIF1A. Mediates transcriptional activation of TP73. In response to TGFB, cooperates with DAXX to activate JNK. Negative regulator through phosphorylation and subsequent proteasomal degradation of CTNNB1 and the antiapoptotic factor CTBP1. In the Wnt/beta-catenin signaling pathway acts as an intermediate kinase between MAP3K7/TAK1 and NLK to promote the proteasomal degradation of MYB. Phosphorylates CBX4 upon DNA damage and promotes its E3 SUMO-protein ligase activity. Activates CREB1 and ATF1 transcription factors by phosphorylation in response to genotoxic stress. In response to DNA damage, stabilizes PML by phosphorylation. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. Promotes angiogenesis, and is involved in erythroid differentiation, especially during fetal liver erythropoiesis. Phosphorylation of RUNX1 and EP300 stimulates EP300 transcription regulation activity. Triggers ZBTB4 protein degradation in response to DNA damage. In response to DNA damage, phosphorylates DAZAP2 which localizes DAZAP2 to the nucleus, reduces interaction of DAZAP2 with HIPK2 and prevents DAZAP2-dependent ubiquitination of HIPK2 by E3 ubiquitin-protein ligase SIAH1 and subsequent proteasomal degradation (PubMed:33591310). Modulates HMGA1 DNA-binding affinity. In response to high glucose, triggers phosphorylation-mediated subnuclear localization shifting of PDX1. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. {ECO:0000269|PubMed:11740489, ECO:0000269|PubMed:11925430, ECO:0000269|PubMed:12851404, ECO:0000269|PubMed:12874272, ECO:0000269|PubMed:14678985, ECO:0000269|PubMed:17018294, ECO:0000269|PubMed:17960875, ECO:0000269|PubMed:18695000, ECO:0000269|PubMed:18809579, ECO:0000269|PubMed:19015637, ECO:0000269|PubMed:19046997, ECO:0000269|PubMed:19448668, ECO:0000269|PubMed:20307497, ECO:0000269|PubMed:20573984, ECO:0000269|PubMed:20637728, ECO:0000269|PubMed:20980392, ECO:0000269|PubMed:21192925, ECO:0000269|PubMed:22825850, ECO:0000269|PubMed:33591310}. |
| P27708 | CAD | S133 | Sugiyama | Multifunctional protein CAD (Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase) [Includes: Glutamine-dependent carbamoyl phosphate synthase (EC 6.3.5.5); Glutamine amidotransferase (GATase) (GLNase) (EC 3.5.1.2); Ammonium-dependent carbamoyl phosphate synthase (CPS) (CPSase) (EC 6.3.4.16); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)] | Multifunctional protein that encodes the first 3 enzymatic activities of the de novo pyrimidine pathway: carbamoylphosphate synthetase (CPSase; EC 6.3.5.5), aspartate transcarbamylase (ATCase; EC 2.1.3.2) and dihydroorotase (DHOase; EC 3.5.2.3). The CPSase-function is accomplished in 2 steps, by a glutamine-dependent amidotransferase activity (GATase) that binds and cleaves glutamine to produce ammonia, followed by an ammonium-dependent carbamoyl phosphate synthetase, which reacts with the ammonia, hydrogencarbonate and ATP to form carbamoyl phosphate. The endogenously produced carbamoyl phosphate is sequestered and channeled to the ATCase active site. ATCase then catalyzes the formation of carbamoyl-L-aspartate from L-aspartate and carbamoyl phosphate. In the last step, DHOase catalyzes the cyclization of carbamoyl aspartate to dihydroorotate. {ECO:0000269|PubMed:24332717}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 0.000001 | 5.839 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.000337 | 3.472 |
| R-HSA-191859 | snRNP Assembly | 0.000337 | 3.472 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.000198 | 3.703 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.001207 | 2.918 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.001299 | 2.886 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.001580 | 2.801 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.001986 | 2.702 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.004061 | 2.391 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.004381 | 2.358 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.004381 | 2.358 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.005066 | 2.295 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.005066 | 2.295 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.005431 | 2.265 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.006208 | 2.207 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.007953 | 2.099 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.008429 | 2.074 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.009734 | 2.012 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.009734 | 2.012 |
| R-HSA-111453 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | 0.004324 | 2.364 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.005596 | 2.252 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.006996 | 2.155 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.007048 | 2.152 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.005431 | 2.265 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.005812 | 2.236 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 0.007859 | 2.105 |
| R-HSA-877312 | Regulation of IFNG signaling | 0.008891 | 2.051 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.008429 | 2.074 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.008429 | 2.074 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.008922 | 2.050 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.007492 | 2.125 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 0.009981 | 2.001 |
| R-HSA-8875878 | MET promotes cell motility | 0.007492 | 2.125 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.007953 | 2.099 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.003016 | 2.521 |
| R-HSA-913531 | Interferon Signaling | 0.009543 | 2.020 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.004278 | 2.369 |
| R-HSA-6806834 | Signaling by MET | 0.007781 | 2.109 |
| R-HSA-2262752 | Cellular responses to stress | 0.004395 | 2.357 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.010088 | 1.996 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.011639 | 1.934 |
| R-HSA-75153 | Apoptotic execution phase | 0.012233 | 1.912 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.012233 | 1.912 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.012385 | 1.907 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 0.013581 | 1.867 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.014592 | 1.836 |
| R-HSA-5632927 | Defective Mismatch Repair Associated With MSH3 | 0.017361 | 1.760 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.016910 | 1.772 |
| R-HSA-77042 | Formation of editosomes by ADAR proteins | 0.017361 | 1.760 |
| R-HSA-9827857 | Specification of primordial germ cells | 0.016247 | 1.789 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.017412 | 1.759 |
| R-HSA-432142 | Platelet sensitization by LDL | 0.017657 | 1.753 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.017924 | 1.747 |
| R-HSA-68882 | Mitotic Anaphase | 0.018229 | 1.739 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.018567 | 1.731 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.019912 | 1.701 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.018975 | 1.722 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.020027 | 1.698 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 0.022184 | 1.654 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.022353 | 1.651 |
| R-HSA-109581 | Apoptosis | 0.021667 | 1.664 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.022579 | 1.646 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.021189 | 1.674 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.021189 | 1.674 |
| R-HSA-205017 | NFG and proNGF binds to p75NTR | 0.025929 | 1.586 |
| R-HSA-5603027 | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... | 0.025929 | 1.586 |
| R-HSA-5602636 | IKBKB deficiency causes SCID | 0.025929 | 1.586 |
| R-HSA-5632928 | Defective Mismatch Repair Associated With MSH2 | 0.025929 | 1.586 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.025440 | 1.594 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 0.025440 | 1.594 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.023231 | 1.634 |
| R-HSA-68886 | M Phase | 0.026137 | 1.583 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.024104 | 1.618 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.025432 | 1.595 |
| R-HSA-1640170 | Cell Cycle | 0.027010 | 1.568 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.027136 | 1.566 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.027136 | 1.566 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.027136 | 1.566 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.027396 | 1.562 |
| R-HSA-3000157 | Laminin interactions | 0.030660 | 1.513 |
| R-HSA-75064 | mRNA Editing: A to I Conversion | 0.034422 | 1.463 |
| R-HSA-75102 | C6 deamination of adenosine | 0.034422 | 1.463 |
| R-HSA-3371556 | Cellular response to heat stress | 0.031590 | 1.500 |
| R-HSA-8874081 | MET activates PTK2 signaling | 0.032487 | 1.488 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.033807 | 1.471 |
| R-HSA-9638630 | Attachment of bacteria to epithelial cells | 0.032487 | 1.488 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.031590 | 1.500 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.034873 | 1.458 |
| R-HSA-209563 | Axonal growth stimulation | 0.042843 | 1.368 |
| R-HSA-8875513 | MET interacts with TNS proteins | 0.042843 | 1.368 |
| R-HSA-68877 | Mitotic Prometaphase | 0.039521 | 1.403 |
| R-HSA-5694530 | Cargo concentration in the ER | 0.042229 | 1.374 |
| R-HSA-5423599 | Diseases of Mismatch Repair (MMR) | 0.042843 | 1.368 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.042229 | 1.374 |
| R-HSA-844455 | The NLRP1 inflammasome | 0.042843 | 1.368 |
| R-HSA-9833482 | PKR-mediated signaling | 0.042817 | 1.368 |
| R-HSA-1538133 | G0 and Early G1 | 0.044293 | 1.354 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.040202 | 1.396 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.037057 | 1.431 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.044293 | 1.354 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.041969 | 1.377 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.045240 | 1.344 |
| R-HSA-354192 | Integrin signaling | 0.046395 | 1.334 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.048532 | 1.314 |
| R-HSA-5357801 | Programmed Cell Death | 0.048749 | 1.312 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.049098 | 1.309 |
| R-HSA-205025 | NADE modulates death signalling | 0.051190 | 1.291 |
| R-HSA-203754 | NOSIP mediated eNOS trafficking | 0.059465 | 1.226 |
| R-HSA-8849472 | PTK6 Down-Regulation | 0.059465 | 1.226 |
| R-HSA-193670 | p75NTR negatively regulates cell cycle via SC1 | 0.051190 | 1.291 |
| R-HSA-9927353 | Co-inhibition by BTLA | 0.059465 | 1.226 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.050285 | 1.299 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.062069 | 1.207 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.052911 | 1.276 |
| R-HSA-9931953 | Biofilm formation | 0.059732 | 1.224 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.057060 | 1.244 |
| R-HSA-162582 | Signal Transduction | 0.050218 | 1.299 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.062143 | 1.207 |
| R-HSA-203641 | NOSTRIN mediated eNOS trafficking | 0.083862 | 1.076 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 0.083862 | 1.076 |
| R-HSA-193692 | Regulated proteolysis of p75NTR | 0.099777 | 1.001 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 0.107631 | 0.968 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.115417 | 0.938 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.115417 | 0.938 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.115417 | 0.938 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.123136 | 0.910 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 0.130788 | 0.883 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.130788 | 0.883 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 0.130788 | 0.883 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.130788 | 0.883 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.130788 | 0.883 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.130788 | 0.883 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.130788 | 0.883 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.138373 | 0.859 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 0.138373 | 0.859 |
| R-HSA-1663150 | The activation of arylsulfatases | 0.145893 | 0.836 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.153347 | 0.814 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.160737 | 0.794 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.168063 | 0.775 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.175326 | 0.756 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 0.182525 | 0.739 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.203751 | 0.691 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.081818 | 1.087 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.071487 | 1.146 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.146626 | 0.834 |
| R-HSA-1989781 | PPARA activates gene expression | 0.194214 | 0.712 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.198657 | 0.702 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.125419 | 0.902 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.125419 | 0.902 |
| R-HSA-193697 | p75NTR regulates axonogenesis | 0.099777 | 1.001 |
| R-HSA-193639 | p75NTR signals via NF-kB | 0.153347 | 0.814 |
| R-HSA-193634 | Axonal growth inhibition (RHOA activation) | 0.091854 | 1.037 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 0.107631 | 0.968 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.125419 | 0.902 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 0.067668 | 1.170 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 0.196737 | 0.706 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.210704 | 0.676 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 0.175326 | 0.756 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.257716 | 0.589 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.079254 | 1.101 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.149643 | 0.825 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.168063 | 0.775 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.123287 | 0.909 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.244575 | 0.612 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 0.145893 | 0.836 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 0.160737 | 0.794 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.240967 | 0.618 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 0.067668 | 1.170 |
| R-HSA-193681 | Ceramide signalling | 0.067668 | 1.170 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 0.099777 | 1.001 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 0.099777 | 1.001 |
| R-HSA-4839744 | Signaling by APC mutants | 0.115417 | 0.938 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.123136 | 0.910 |
| R-HSA-209560 | NF-kB is activated and signals survival | 0.123136 | 0.910 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.123136 | 0.910 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.123136 | 0.910 |
| R-HSA-1482883 | Acyl chain remodeling of DAG and TAG | 0.138373 | 0.859 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 0.138373 | 0.859 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.153347 | 0.814 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.231203 | 0.636 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.192003 | 0.717 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.176712 | 0.753 |
| R-HSA-500753 | Pyrimidine biosynthesis | 0.189662 | 0.722 |
| R-HSA-5358508 | Mismatch Repair | 0.182525 | 0.739 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.182525 | 0.739 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 0.182525 | 0.739 |
| R-HSA-75072 | mRNA Editing | 0.099777 | 1.001 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 0.153347 | 0.814 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 0.189662 | 0.722 |
| R-HSA-420029 | Tight junction interactions | 0.237918 | 0.624 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 0.257716 | 0.589 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.270630 | 0.568 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 0.091854 | 1.037 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.251174 | 0.600 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.260342 | 0.584 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.125896 | 0.900 |
| R-HSA-390696 | Adrenoceptors | 0.091854 | 1.037 |
| R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 0.091854 | 1.037 |
| R-HSA-198693 | AKT phosphorylates targets in the nucleus | 0.099777 | 1.001 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 0.130788 | 0.883 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 0.130788 | 0.883 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 0.145893 | 0.836 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.210704 | 0.676 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.100446 | 0.998 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 0.107631 | 0.968 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.205692 | 0.687 |
| R-HSA-391906 | Leukotriene receptors | 0.075800 | 1.120 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.115417 | 0.938 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 0.153347 | 0.814 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.251174 | 0.600 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.193007 | 0.714 |
| R-HSA-199991 | Membrane Trafficking | 0.233388 | 0.632 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.182525 | 0.739 |
| R-HSA-1474165 | Reproduction | 0.137190 | 0.863 |
| R-HSA-449836 | Other interleukin signaling | 0.189662 | 0.722 |
| R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 0.067668 | 1.170 |
| R-HSA-5578768 | Physiological factors | 0.145893 | 0.836 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 0.175326 | 0.756 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 0.224430 | 0.649 |
| R-HSA-77387 | Insulin receptor recycling | 0.257716 | 0.589 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.187599 | 0.727 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.164908 | 0.783 |
| R-HSA-8953854 | Metabolism of RNA | 0.218267 | 0.661 |
| R-HSA-210990 | PECAM1 interactions | 0.115417 | 0.938 |
| R-HSA-9620244 | Long-term potentiation | 0.237918 | 0.624 |
| R-HSA-392154 | Nitric oxide stimulates guanylate cyclase | 0.264201 | 0.578 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.108508 | 0.965 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.194214 | 0.712 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.189853 | 0.722 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.180434 | 0.744 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.098451 | 1.007 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.096027 | 1.018 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.145893 | 0.836 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.160737 | 0.794 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 0.270630 | 0.568 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.241944 | 0.616 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.130788 | 0.883 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 0.145893 | 0.836 |
| R-HSA-196836 | Vitamin C (ascorbate) metabolism | 0.203751 | 0.691 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.270630 | 0.568 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.151378 | 0.820 |
| R-HSA-9610379 | HCMV Late Events | 0.198657 | 0.702 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.091854 | 1.037 |
| R-HSA-391160 | Signal regulatory protein family interactions | 0.145893 | 0.836 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 0.210704 | 0.676 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.174557 | 0.758 |
| R-HSA-418346 | Platelet homeostasis | 0.085835 | 1.066 |
| R-HSA-8939211 | ESR-mediated signaling | 0.076463 | 1.117 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.177310 | 0.751 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.121582 | 0.915 |
| R-HSA-70171 | Glycolysis | 0.074574 | 1.127 |
| R-HSA-168255 | Influenza Infection | 0.251259 | 0.600 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.196737 | 0.706 |
| R-HSA-9707616 | Heme signaling | 0.125896 | 0.900 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.108758 | 0.964 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.128812 | 0.890 |
| R-HSA-8848021 | Signaling by PTK6 | 0.128812 | 0.890 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.217597 | 0.662 |
| R-HSA-8854691 | Interleukin-20 family signaling | 0.224430 | 0.649 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.101300 | 0.994 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.212330 | 0.673 |
| R-HSA-391903 | Eicosanoid ligand-binding receptors | 0.196737 | 0.706 |
| R-HSA-449147 | Signaling by Interleukins | 0.206646 | 0.685 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.183565 | 0.736 |
| R-HSA-68875 | Mitotic Prophase | 0.114041 | 0.943 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.245780 | 0.609 |
| R-HSA-189200 | Cellular hexose transport | 0.217597 | 0.662 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.089661 | 1.047 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.270630 | 0.568 |
| R-HSA-74160 | Gene expression (Transcription) | 0.148739 | 0.828 |
| R-HSA-70326 | Glucose metabolism | 0.108508 | 0.965 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.120112 | 0.920 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.120112 | 0.920 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.120112 | 0.920 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.120112 | 0.920 |
| R-HSA-2022377 | Metabolism of Angiotensinogen to Angiotensins | 0.210704 | 0.676 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.131744 | 0.880 |
| R-HSA-3000178 | ECM proteoglycans | 0.152673 | 0.816 |
| R-HSA-622312 | Inflammasomes | 0.257716 | 0.589 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.106585 | 0.972 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.120112 | 0.920 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.167994 | 0.775 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.166012 | 0.780 |
| R-HSA-211000 | Gene Silencing by RNA | 0.087500 | 1.058 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.193214 | 0.714 |
| R-HSA-72306 | tRNA processing | 0.230385 | 0.638 |
| R-HSA-162587 | HIV Life Cycle | 0.198657 | 0.702 |
| R-HSA-5619102 | SLC transporter disorders | 0.221217 | 0.655 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.277003 | 0.558 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.283320 | 0.548 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.283320 | 0.548 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.289583 | 0.538 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.289583 | 0.538 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.289583 | 0.538 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.289583 | 0.538 |
| R-HSA-9609690 | HCMV Early Events | 0.291358 | 0.536 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.295792 | 0.529 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 0.295792 | 0.529 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.298233 | 0.525 |
| R-HSA-597592 | Post-translational protein modification | 0.301404 | 0.521 |
| R-HSA-203615 | eNOS activation | 0.301946 | 0.520 |
| R-HSA-5205647 | Mitophagy | 0.301946 | 0.520 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 0.301946 | 0.520 |
| R-HSA-5673000 | RAF activation | 0.301946 | 0.520 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.301946 | 0.520 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.301946 | 0.520 |
| R-HSA-212436 | Generic Transcription Pathway | 0.302055 | 0.520 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.302521 | 0.519 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.305639 | 0.515 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.311960 | 0.506 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.314096 | 0.503 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.314096 | 0.503 |
| R-HSA-3371511 | HSF1 activation | 0.314096 | 0.503 |
| R-HSA-111933 | Calmodulin induced events | 0.314096 | 0.503 |
| R-HSA-111997 | CaM pathway | 0.314096 | 0.503 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.314096 | 0.503 |
| R-HSA-8853659 | RET signaling | 0.314096 | 0.503 |
| R-HSA-373760 | L1CAM interactions | 0.315169 | 0.501 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.318375 | 0.497 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.320092 | 0.495 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.321578 | 0.493 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 0.326035 | 0.487 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.331885 | 0.479 |
| R-HSA-397014 | Muscle contraction | 0.331885 | 0.479 |
| R-HSA-71336 | Pentose phosphate pathway | 0.331927 | 0.479 |
| R-HSA-201556 | Signaling by ALK | 0.331927 | 0.479 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.337532 | 0.472 |
| R-HSA-3371568 | Attenuation phase | 0.337768 | 0.471 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.337768 | 0.471 |
| R-HSA-5260271 | Diseases of Immune System | 0.337768 | 0.471 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.337768 | 0.471 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.343559 | 0.464 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.343559 | 0.464 |
| R-HSA-194138 | Signaling by VEGF | 0.347052 | 0.460 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.349299 | 0.457 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.349299 | 0.457 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.349299 | 0.457 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.349299 | 0.457 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.353519 | 0.452 |
| R-HSA-111996 | Ca-dependent events | 0.354989 | 0.450 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.354989 | 0.450 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.360630 | 0.443 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.360630 | 0.443 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.365245 | 0.437 |
| R-HSA-69236 | G1 Phase | 0.366221 | 0.436 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.366221 | 0.436 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.366221 | 0.436 |
| R-HSA-375280 | Amine ligand-binding receptors | 0.366221 | 0.436 |
| R-HSA-162906 | HIV Infection | 0.367621 | 0.435 |
| R-HSA-9843745 | Adipogenesis | 0.369085 | 0.433 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.371765 | 0.430 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.371765 | 0.430 |
| R-HSA-9909396 | Circadian clock | 0.372210 | 0.429 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.372210 | 0.429 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.377260 | 0.423 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.377260 | 0.423 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.377260 | 0.423 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.377260 | 0.423 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.377260 | 0.423 |
| R-HSA-9675135 | Diseases of DNA repair | 0.377260 | 0.423 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.382707 | 0.417 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.388107 | 0.411 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.388107 | 0.411 |
| R-HSA-9679506 | SARS-CoV Infections | 0.391798 | 0.407 |
| R-HSA-2162123 | Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | 0.398767 | 0.399 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.404027 | 0.394 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.404027 | 0.394 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.404027 | 0.394 |
| R-HSA-9864848 | Complex IV assembly | 0.404027 | 0.394 |
| R-HSA-6798695 | Neutrophil degranulation | 0.407873 | 0.389 |
| R-HSA-109582 | Hemostasis | 0.408696 | 0.389 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.409242 | 0.388 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.409242 | 0.388 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.414412 | 0.383 |
| R-HSA-1221632 | Meiotic synapsis | 0.414412 | 0.383 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.414412 | 0.383 |
| R-HSA-8956320 | Nucleotide biosynthesis | 0.414412 | 0.383 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.414725 | 0.382 |
| R-HSA-9609646 | HCMV Infection | 0.421706 | 0.375 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.424616 | 0.372 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.424616 | 0.372 |
| R-HSA-73894 | DNA Repair | 0.426548 | 0.370 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.429652 | 0.367 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.429652 | 0.367 |
| R-HSA-75893 | TNF signaling | 0.429652 | 0.367 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.433266 | 0.363 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.433619 | 0.363 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.439203 | 0.357 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.442159 | 0.354 |
| R-HSA-73887 | Death Receptor Signaling | 0.445106 | 0.352 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.449362 | 0.347 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.454183 | 0.343 |
| R-HSA-112043 | PLC beta mediated events | 0.454183 | 0.343 |
| R-HSA-450294 | MAP kinase activation | 0.454183 | 0.343 |
| R-HSA-211976 | Endogenous sterols | 0.454183 | 0.343 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.456809 | 0.340 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.458962 | 0.338 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.458962 | 0.338 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.458962 | 0.338 |
| R-HSA-877300 | Interferon gamma signaling | 0.459713 | 0.338 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.463699 | 0.334 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.463699 | 0.334 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.463699 | 0.334 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.463699 | 0.334 |
| R-HSA-373755 | Semaphorin interactions | 0.463699 | 0.334 |
| R-HSA-5690714 | CD22 mediated BCR regulation | 0.468395 | 0.329 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.468395 | 0.329 |
| R-HSA-211981 | Xenobiotics | 0.468395 | 0.329 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.473051 | 0.325 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.473051 | 0.325 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.473051 | 0.325 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.476436 | 0.322 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.477666 | 0.321 |
| R-HSA-112040 | G-protein mediated events | 0.482240 | 0.317 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.486775 | 0.313 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.486775 | 0.313 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.495727 | 0.305 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.495727 | 0.305 |
| R-HSA-9840310 | Glycosphingolipid catabolism | 0.495727 | 0.305 |
| R-HSA-448424 | Interleukin-17 signaling | 0.495727 | 0.305 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.495727 | 0.305 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.500145 | 0.301 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.500145 | 0.301 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.500145 | 0.301 |
| R-HSA-8978934 | Metabolism of cofactors | 0.500145 | 0.301 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.504524 | 0.297 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.504524 | 0.297 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.508865 | 0.293 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.508865 | 0.293 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.508865 | 0.293 |
| R-HSA-1222556 | ROS and RNS production in phagocytes | 0.513168 | 0.290 |
| R-HSA-380287 | Centrosome maturation | 0.517434 | 0.286 |
| R-HSA-5689603 | UCH proteinases | 0.521663 | 0.283 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.530011 | 0.276 |
| R-HSA-6783783 | Interleukin-10 signaling | 0.530011 | 0.276 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.530011 | 0.276 |
| R-HSA-9659379 | Sensory processing of sound | 0.534130 | 0.272 |
| R-HSA-69275 | G2/M Transition | 0.537195 | 0.270 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.538214 | 0.269 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.542262 | 0.266 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.542433 | 0.266 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.550252 | 0.259 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.552787 | 0.257 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.554195 | 0.256 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.554195 | 0.256 |
| R-HSA-422475 | Axon guidance | 0.554780 | 0.256 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.557903 | 0.253 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.558104 | 0.253 |
| R-HSA-1500620 | Meiosis | 0.558104 | 0.253 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.558104 | 0.253 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.558104 | 0.253 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.565820 | 0.247 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 0.565820 | 0.247 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.573402 | 0.242 |
| R-HSA-9663891 | Selective autophagy | 0.573402 | 0.242 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.574011 | 0.241 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.577144 | 0.239 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.579980 | 0.237 |
| R-HSA-9640148 | Infection with Enterobacteria | 0.580409 | 0.236 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.580853 | 0.236 |
| R-HSA-202424 | Downstream TCR signaling | 0.580853 | 0.236 |
| R-HSA-72172 | mRNA Splicing | 0.585296 | 0.233 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.591787 | 0.228 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.595368 | 0.225 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.601907 | 0.220 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.602438 | 0.220 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.606771 | 0.217 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.609385 | 0.215 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.609385 | 0.215 |
| R-HSA-9675108 | Nervous system development | 0.611219 | 0.214 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.612813 | 0.213 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.616211 | 0.210 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.616211 | 0.210 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.616211 | 0.210 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.619580 | 0.208 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.625813 | 0.204 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.626229 | 0.203 |
| R-HSA-1483255 | PI Metabolism | 0.629511 | 0.201 |
| R-HSA-111885 | Opioid Signalling | 0.635988 | 0.197 |
| R-HSA-163125 | Post-translational modification: synthesis of GPI-anchored proteins | 0.639184 | 0.194 |
| R-HSA-9833110 | RSV-host interactions | 0.639184 | 0.194 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.642352 | 0.192 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.642352 | 0.192 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.648607 | 0.188 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.651693 | 0.186 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.651693 | 0.186 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.654752 | 0.184 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.657785 | 0.182 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.657785 | 0.182 |
| R-HSA-202403 | TCR signaling | 0.657785 | 0.182 |
| R-HSA-168256 | Immune System | 0.660889 | 0.180 |
| R-HSA-157118 | Signaling by NOTCH | 0.666139 | 0.176 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.666725 | 0.176 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.669653 | 0.174 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.675433 | 0.170 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.675433 | 0.170 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.683915 | 0.165 |
| R-HSA-5693538 | Homology Directed Repair | 0.686693 | 0.163 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.689447 | 0.161 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.689447 | 0.161 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.689582 | 0.161 |
| R-HSA-5688426 | Deubiquitination | 0.695908 | 0.157 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.697566 | 0.156 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.697566 | 0.156 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.697813 | 0.156 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.700225 | 0.155 |
| R-HSA-1660662 | Glycosphingolipid metabolism | 0.700225 | 0.155 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.702861 | 0.153 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.710876 | 0.148 |
| R-HSA-416476 | G alpha (q) signalling events | 0.712704 | 0.147 |
| R-HSA-114608 | Platelet degranulation | 0.713176 | 0.147 |
| R-HSA-69481 | G2/M Checkpoints | 0.713176 | 0.147 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.720678 | 0.142 |
| R-HSA-5576891 | Cardiac conduction | 0.725571 | 0.139 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.727985 | 0.138 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.730379 | 0.136 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.742036 | 0.130 |
| R-HSA-6807070 | PTEN Regulation | 0.746557 | 0.127 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.747689 | 0.126 |
| R-HSA-1632852 | Macroautophagy | 0.751000 | 0.124 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.755344 | 0.122 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.757519 | 0.121 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.759654 | 0.119 |
| R-HSA-1483257 | Phospholipid metabolism | 0.764735 | 0.116 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.766270 | 0.116 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.768010 | 0.115 |
| R-HSA-69242 | S Phase | 0.768010 | 0.115 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.772079 | 0.112 |
| R-HSA-2142753 | Arachidonate metabolism | 0.776078 | 0.110 |
| R-HSA-9612973 | Autophagy | 0.783866 | 0.106 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.791386 | 0.102 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.791386 | 0.102 |
| R-HSA-1500931 | Cell-Cell communication | 0.795197 | 0.100 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 0.803926 | 0.095 |
| R-HSA-112316 | Neuronal System | 0.804783 | 0.094 |
| R-HSA-8957322 | Metabolism of steroids | 0.805860 | 0.094 |
| R-HSA-392499 | Metabolism of proteins | 0.811478 | 0.091 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.812422 | 0.090 |
| R-HSA-1474244 | Extracellular matrix organization | 0.814786 | 0.089 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.815717 | 0.088 |
| R-HSA-611105 | Respiratory electron transport | 0.823705 | 0.084 |
| R-HSA-2559583 | Cellular Senescence | 0.826803 | 0.083 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.831349 | 0.080 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.838665 | 0.076 |
| R-HSA-5617833 | Cilium Assembly | 0.841502 | 0.075 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.842902 | 0.074 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.852131 | 0.069 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.854961 | 0.068 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.854961 | 0.068 |
| R-HSA-428157 | Sphingolipid metabolism | 0.856243 | 0.067 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.858773 | 0.066 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.858773 | 0.066 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.858773 | 0.066 |
| R-HSA-6805567 | Keratinization | 0.863701 | 0.064 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.877472 | 0.057 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.880869 | 0.055 |
| R-HSA-9824446 | Viral Infection Pathways | 0.882208 | 0.054 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.889882 | 0.051 |
| R-HSA-72312 | rRNA processing | 0.891824 | 0.050 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.893731 | 0.049 |
| R-HSA-15869 | Metabolism of nucleotides | 0.895606 | 0.048 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.896530 | 0.047 |
| R-HSA-4839726 | Chromatin organization | 0.907013 | 0.042 |
| R-HSA-421270 | Cell-cell junction organization | 0.908654 | 0.042 |
| R-HSA-1280218 | Adaptive Immune System | 0.911163 | 0.040 |
| R-HSA-168249 | Innate Immune System | 0.912034 | 0.040 |
| R-HSA-1643685 | Disease | 0.927988 | 0.032 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.928193 | 0.032 |
| R-HSA-446728 | Cell junction organization | 0.928193 | 0.032 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.928414 | 0.032 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.930711 | 0.031 |
| R-HSA-1266738 | Developmental Biology | 0.935901 | 0.029 |
| R-HSA-195721 | Signaling by WNT | 0.939934 | 0.027 |
| R-HSA-556833 | Metabolism of lipids | 0.959061 | 0.018 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.959113 | 0.018 |
| R-HSA-5663205 | Infectious disease | 0.969517 | 0.013 |
| R-HSA-500792 | GPCR ligand binding | 0.971713 | 0.012 |
| R-HSA-388396 | GPCR downstream signalling | 0.972266 | 0.012 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.975483 | 0.011 |
| R-HSA-418594 | G alpha (i) signalling events | 0.977592 | 0.010 |
| R-HSA-8978868 | Fatty acid metabolism | 0.977592 | 0.010 |
| R-HSA-72766 | Translation | 0.981618 | 0.008 |
| R-HSA-372790 | Signaling by GPCR | 0.984529 | 0.007 |
| R-HSA-211859 | Biological oxidations | 0.992138 | 0.003 |
| R-HSA-382551 | Transport of small molecules | 0.993736 | 0.003 |
| R-HSA-1430728 | Metabolism | 0.999911 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999990 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
MST4 |
0.838 | 0.338 | 2 | 0.859 |
SRPK1 |
0.835 | 0.281 | -3 | 0.869 |
SRPK2 |
0.833 | 0.296 | -3 | 0.824 |
CLK3 |
0.833 | 0.201 | 1 | 0.518 |
PRKD2 |
0.830 | 0.260 | -3 | 0.870 |
NDR2 |
0.829 | 0.202 | -3 | 0.884 |
PRKD1 |
0.829 | 0.238 | -3 | 0.880 |
COT |
0.829 | 0.121 | 2 | 0.797 |
PKN3 |
0.828 | 0.235 | -3 | 0.871 |
PIM1 |
0.827 | 0.250 | -3 | 0.891 |
PKCD |
0.827 | 0.270 | 2 | 0.763 |
MTOR |
0.826 | 0.236 | 1 | 0.618 |
RSK2 |
0.826 | 0.248 | -3 | 0.872 |
NUAK2 |
0.826 | 0.228 | -3 | 0.888 |
PIM3 |
0.825 | 0.188 | -3 | 0.901 |
P90RSK |
0.825 | 0.248 | -3 | 0.875 |
SRPK3 |
0.825 | 0.295 | -3 | 0.841 |
NDR1 |
0.825 | 0.212 | -3 | 0.882 |
PKN2 |
0.823 | 0.248 | -3 | 0.865 |
MAPKAPK2 |
0.823 | 0.219 | -3 | 0.857 |
CDKL1 |
0.822 | 0.248 | -3 | 0.877 |
LATS2 |
0.821 | 0.170 | -5 | 0.786 |
RAF1 |
0.821 | 0.309 | 1 | 0.662 |
TBK1 |
0.821 | 0.276 | 1 | 0.684 |
CLK2 |
0.821 | 0.263 | -3 | 0.875 |
MAPKAPK3 |
0.821 | 0.219 | -3 | 0.860 |
CAMK2D |
0.820 | 0.222 | -3 | 0.855 |
RSK3 |
0.820 | 0.234 | -3 | 0.861 |
CLK1 |
0.820 | 0.245 | -3 | 0.846 |
CDKL5 |
0.819 | 0.198 | -3 | 0.878 |
IKKE |
0.818 | 0.280 | 1 | 0.704 |
PKCA |
0.818 | 0.258 | 2 | 0.719 |
WNK1 |
0.816 | 0.191 | -2 | 0.895 |
BCKDK |
0.816 | 0.202 | -1 | 0.722 |
CAMK1B |
0.816 | 0.186 | -3 | 0.878 |
PKACG |
0.816 | 0.200 | -2 | 0.778 |
IKKB |
0.815 | 0.107 | -2 | 0.765 |
PKCG |
0.815 | 0.226 | 2 | 0.715 |
PHKG1 |
0.815 | 0.195 | -3 | 0.876 |
PKACB |
0.815 | 0.218 | -2 | 0.719 |
RSK4 |
0.815 | 0.237 | -3 | 0.866 |
CLK4 |
0.815 | 0.215 | -3 | 0.868 |
CAMK2B |
0.814 | 0.180 | 2 | 0.746 |
PKCB |
0.814 | 0.195 | 2 | 0.719 |
AMPKA1 |
0.814 | 0.174 | -3 | 0.884 |
AMPKA2 |
0.814 | 0.191 | -3 | 0.878 |
NEK6 |
0.814 | 0.060 | -2 | 0.908 |
MSK2 |
0.814 | 0.205 | -3 | 0.856 |
DSTYK |
0.814 | 0.082 | 2 | 0.833 |
PDHK1 |
0.814 | 0.239 | 1 | 0.671 |
PRKD3 |
0.813 | 0.235 | -3 | 0.841 |
NLK |
0.813 | 0.089 | 1 | 0.581 |
TGFBR2 |
0.813 | 0.112 | -2 | 0.865 |
NUAK1 |
0.813 | 0.173 | -3 | 0.859 |
NIK |
0.813 | 0.240 | -3 | 0.861 |
P70S6KB |
0.813 | 0.205 | -3 | 0.869 |
AKT2 |
0.812 | 0.262 | -3 | 0.826 |
AURC |
0.812 | 0.146 | -2 | 0.688 |
GCN2 |
0.811 | -0.036 | 2 | 0.734 |
PRKX |
0.811 | 0.227 | -3 | 0.820 |
PDHK4 |
0.811 | 0.121 | 1 | 0.643 |
CDC7 |
0.811 | -0.024 | 1 | 0.515 |
ICK |
0.811 | 0.180 | -3 | 0.891 |
LATS1 |
0.811 | 0.237 | -3 | 0.872 |
CAMK2A |
0.811 | 0.171 | 2 | 0.768 |
SIK |
0.810 | 0.230 | -3 | 0.840 |
TSSK1 |
0.810 | 0.167 | -3 | 0.893 |
AKT1 |
0.809 | 0.268 | -3 | 0.835 |
SGK3 |
0.809 | 0.260 | -3 | 0.849 |
MSK1 |
0.809 | 0.208 | -3 | 0.854 |
ULK2 |
0.809 | 0.010 | 2 | 0.713 |
MNK2 |
0.809 | 0.141 | -2 | 0.831 |
PRPK |
0.808 | -0.007 | -1 | 0.726 |
MARK4 |
0.808 | 0.137 | 4 | 0.760 |
NEK7 |
0.808 | 0.030 | -3 | 0.751 |
HIPK4 |
0.808 | 0.117 | 1 | 0.510 |
CAMK4 |
0.808 | 0.125 | -3 | 0.857 |
PKCH |
0.808 | 0.199 | 2 | 0.690 |
MNK1 |
0.807 | 0.151 | -2 | 0.836 |
QSK |
0.807 | 0.197 | 4 | 0.731 |
PIM2 |
0.806 | 0.240 | -3 | 0.851 |
PHKG2 |
0.806 | 0.237 | -3 | 0.840 |
NIM1 |
0.805 | 0.177 | 3 | 0.794 |
MOS |
0.805 | -0.035 | 1 | 0.530 |
CAMLCK |
0.805 | 0.138 | -2 | 0.876 |
SKMLCK |
0.804 | 0.092 | -2 | 0.882 |
CHK1 |
0.804 | 0.169 | -3 | 0.848 |
PKCT |
0.804 | 0.217 | 2 | 0.699 |
DCAMKL1 |
0.804 | 0.217 | -3 | 0.870 |
BMPR2 |
0.804 | 0.016 | -2 | 0.916 |
CAMK2G |
0.804 | -0.005 | 2 | 0.762 |
MELK |
0.803 | 0.141 | -3 | 0.862 |
DNAPK |
0.803 | 0.164 | 1 | 0.594 |
DAPK2 |
0.802 | 0.136 | -3 | 0.870 |
HIPK2 |
0.802 | 0.113 | 1 | 0.405 |
AURB |
0.802 | 0.143 | -2 | 0.688 |
TSSK2 |
0.802 | 0.098 | -5 | 0.874 |
HIPK1 |
0.802 | 0.149 | 1 | 0.475 |
PKCZ |
0.801 | 0.126 | 2 | 0.739 |
YSK4 |
0.801 | 0.207 | 1 | 0.653 |
ERK5 |
0.801 | -0.024 | 1 | 0.559 |
DYRK2 |
0.801 | 0.089 | 1 | 0.465 |
PKACA |
0.801 | 0.214 | -2 | 0.663 |
BRSK1 |
0.801 | 0.137 | -3 | 0.861 |
QIK |
0.801 | 0.159 | -3 | 0.835 |
NEK9 |
0.801 | 0.055 | 2 | 0.780 |
ATR |
0.801 | -0.019 | 1 | 0.540 |
AKT3 |
0.800 | 0.259 | -3 | 0.799 |
MLK1 |
0.799 | -0.007 | 2 | 0.775 |
WNK3 |
0.799 | 0.046 | 1 | 0.611 |
IKKA |
0.799 | 0.034 | -2 | 0.745 |
PKG2 |
0.799 | 0.157 | -2 | 0.708 |
AURA |
0.799 | 0.141 | -2 | 0.655 |
HUNK |
0.798 | -0.034 | 2 | 0.672 |
CDK10 |
0.798 | 0.119 | 1 | 0.424 |
MYLK4 |
0.798 | 0.141 | -2 | 0.808 |
KIS |
0.798 | 0.008 | 1 | 0.466 |
CAMK1G |
0.797 | 0.154 | -3 | 0.849 |
DLK |
0.797 | 0.032 | 1 | 0.594 |
BRSK2 |
0.797 | 0.103 | -3 | 0.852 |
NEK2 |
0.797 | 0.133 | 2 | 0.768 |
P70S6K |
0.797 | 0.217 | -3 | 0.815 |
PKCE |
0.797 | 0.227 | 2 | 0.703 |
IRE1 |
0.797 | 0.030 | 1 | 0.509 |
CDK13 |
0.797 | 0.033 | 1 | 0.443 |
MAPKAPK5 |
0.797 | 0.146 | -3 | 0.819 |
PKN1 |
0.797 | 0.228 | -3 | 0.824 |
MST3 |
0.797 | 0.256 | 2 | 0.805 |
PAK1 |
0.797 | 0.092 | -2 | 0.800 |
RIPK3 |
0.796 | -0.055 | 3 | 0.733 |
PKCI |
0.796 | 0.186 | 2 | 0.724 |
ULK1 |
0.796 | -0.073 | -3 | 0.724 |
CHAK2 |
0.796 | -0.012 | -1 | 0.704 |
KHS2 |
0.796 | 0.470 | 1 | 0.718 |
ANKRD3 |
0.796 | 0.054 | 1 | 0.612 |
TAO3 |
0.796 | 0.261 | 1 | 0.623 |
PAK3 |
0.796 | 0.082 | -2 | 0.808 |
SGK1 |
0.796 | 0.275 | -3 | 0.783 |
CDK5 |
0.796 | 0.056 | 1 | 0.452 |
CDK8 |
0.795 | -0.014 | 1 | 0.460 |
CAMK1D |
0.795 | 0.204 | -3 | 0.813 |
CHK2 |
0.795 | 0.262 | -3 | 0.787 |
CDK19 |
0.795 | -0.005 | 1 | 0.436 |
CDK12 |
0.794 | 0.045 | 1 | 0.435 |
CDK18 |
0.794 | 0.030 | 1 | 0.406 |
IRE2 |
0.794 | 0.047 | 2 | 0.689 |
MASTL |
0.794 | -0.039 | -2 | 0.843 |
CDK7 |
0.794 | -0.004 | 1 | 0.454 |
FAM20C |
0.793 | 0.060 | 2 | 0.617 |
PKR |
0.793 | 0.115 | 1 | 0.557 |
CDK9 |
0.793 | 0.024 | 1 | 0.455 |
RIPK1 |
0.793 | -0.027 | 1 | 0.551 |
KHS1 |
0.792 | 0.471 | 1 | 0.713 |
CDK1 |
0.792 | 0.023 | 1 | 0.422 |
GCK |
0.792 | 0.401 | 1 | 0.683 |
MARK3 |
0.792 | 0.108 | 4 | 0.683 |
HIPK3 |
0.792 | 0.125 | 1 | 0.505 |
ATM |
0.791 | -0.025 | 1 | 0.491 |
DYRK3 |
0.791 | 0.148 | 1 | 0.476 |
HPK1 |
0.791 | 0.429 | 1 | 0.706 |
MLK3 |
0.791 | -0.001 | 2 | 0.727 |
MLK2 |
0.790 | -0.057 | 2 | 0.765 |
PAK6 |
0.790 | 0.094 | -2 | 0.728 |
DCAMKL2 |
0.790 | 0.138 | -3 | 0.866 |
DYRK1A |
0.790 | 0.123 | 1 | 0.500 |
GRK1 |
0.789 | 0.004 | -2 | 0.780 |
WNK4 |
0.789 | 0.149 | -2 | 0.887 |
GRK5 |
0.789 | -0.130 | -3 | 0.788 |
CDK14 |
0.788 | 0.065 | 1 | 0.445 |
MARK1 |
0.788 | 0.112 | 4 | 0.720 |
MARK2 |
0.788 | 0.092 | 4 | 0.639 |
DYRK1B |
0.788 | 0.088 | 1 | 0.436 |
PLK1 |
0.788 | -0.001 | -2 | 0.875 |
PLK4 |
0.788 | 0.075 | 2 | 0.501 |
BMPR1B |
0.788 | 0.010 | 1 | 0.483 |
CAMK1A |
0.788 | 0.212 | -3 | 0.798 |
PAK2 |
0.788 | 0.072 | -2 | 0.790 |
SBK |
0.787 | 0.244 | -3 | 0.752 |
CDK17 |
0.787 | 0.008 | 1 | 0.375 |
GRK6 |
0.787 | -0.054 | 1 | 0.555 |
CHAK1 |
0.787 | 0.019 | 2 | 0.723 |
MRCKA |
0.787 | 0.247 | -3 | 0.842 |
SNRK |
0.787 | 0.021 | 2 | 0.593 |
GRK7 |
0.786 | 0.038 | 1 | 0.522 |
MRCKB |
0.786 | 0.251 | -3 | 0.834 |
TNIK |
0.786 | 0.349 | 3 | 0.891 |
ZAK |
0.786 | 0.081 | 1 | 0.598 |
JNK2 |
0.786 | 0.019 | 1 | 0.446 |
SMMLCK |
0.786 | 0.160 | -3 | 0.862 |
DYRK4 |
0.786 | 0.072 | 1 | 0.419 |
HGK |
0.786 | 0.323 | 3 | 0.892 |
ALK4 |
0.786 | -0.001 | -2 | 0.881 |
MINK |
0.785 | 0.392 | 1 | 0.686 |
TGFBR1 |
0.785 | 0.006 | -2 | 0.863 |
MEK1 |
0.785 | 0.011 | 2 | 0.756 |
MEKK1 |
0.784 | 0.090 | 1 | 0.598 |
MLK4 |
0.784 | -0.025 | 2 | 0.688 |
HRI |
0.783 | 0.025 | -2 | 0.897 |
CDK16 |
0.783 | 0.034 | 1 | 0.381 |
TAO2 |
0.782 | 0.207 | 2 | 0.804 |
CDK3 |
0.782 | 0.027 | 1 | 0.382 |
MAK |
0.782 | 0.164 | -2 | 0.678 |
MEKK3 |
0.782 | 0.054 | 1 | 0.619 |
TTBK2 |
0.781 | -0.070 | 2 | 0.612 |
DRAK1 |
0.781 | -0.030 | 1 | 0.514 |
P38A |
0.781 | -0.005 | 1 | 0.493 |
JNK3 |
0.781 | -0.007 | 1 | 0.457 |
MEKK2 |
0.781 | 0.097 | 2 | 0.736 |
ALK2 |
0.781 | -0.000 | -2 | 0.867 |
GRK4 |
0.781 | -0.099 | -2 | 0.840 |
P38G |
0.781 | -0.002 | 1 | 0.383 |
MOK |
0.781 | 0.172 | 1 | 0.470 |
ERK1 |
0.780 | -0.015 | 1 | 0.454 |
MEK5 |
0.780 | 0.045 | 2 | 0.759 |
TLK2 |
0.780 | 0.007 | 1 | 0.575 |
ACVR2A |
0.780 | -0.023 | -2 | 0.850 |
ROCK2 |
0.779 | 0.240 | -3 | 0.866 |
PLK3 |
0.779 | -0.041 | 2 | 0.693 |
CDK2 |
0.778 | -0.017 | 1 | 0.479 |
VRK2 |
0.778 | -0.081 | 1 | 0.580 |
NEK5 |
0.778 | 0.035 | 1 | 0.577 |
MST2 |
0.778 | 0.221 | 1 | 0.659 |
PASK |
0.778 | 0.072 | -3 | 0.887 |
PERK |
0.778 | -0.015 | -2 | 0.879 |
CDK4 |
0.777 | 0.059 | 1 | 0.423 |
BRAF |
0.777 | 0.029 | -4 | 0.778 |
PAK5 |
0.777 | 0.090 | -2 | 0.668 |
LOK |
0.777 | 0.202 | -2 | 0.805 |
NEK11 |
0.777 | 0.131 | 1 | 0.636 |
SMG1 |
0.777 | -0.073 | 1 | 0.515 |
ERK2 |
0.776 | -0.037 | 1 | 0.476 |
CRIK |
0.776 | 0.249 | -3 | 0.840 |
ACVR2B |
0.776 | -0.042 | -2 | 0.859 |
TLK1 |
0.776 | 0.024 | -2 | 0.875 |
IRAK4 |
0.776 | -0.001 | 1 | 0.531 |
SSTK |
0.776 | 0.037 | 4 | 0.737 |
YSK1 |
0.776 | 0.227 | 2 | 0.782 |
DAPK3 |
0.775 | 0.143 | -3 | 0.877 |
P38B |
0.775 | -0.020 | 1 | 0.454 |
NEK4 |
0.775 | 0.195 | 1 | 0.633 |
MST1 |
0.773 | 0.242 | 1 | 0.668 |
CK1G1 |
0.773 | 0.071 | -3 | 0.549 |
NEK8 |
0.773 | 0.033 | 2 | 0.766 |
CDK6 |
0.773 | 0.050 | 1 | 0.431 |
MAP3K15 |
0.773 | 0.153 | 1 | 0.610 |
ROCK1 |
0.772 | 0.240 | -3 | 0.846 |
PDK1 |
0.772 | 0.131 | 1 | 0.594 |
SLK |
0.772 | 0.139 | -2 | 0.737 |
BMPR1A |
0.772 | -0.010 | 1 | 0.462 |
MEKK6 |
0.772 | 0.147 | 1 | 0.610 |
ERK7 |
0.771 | 0.037 | 2 | 0.574 |
EEF2K |
0.771 | 0.130 | 3 | 0.880 |
DMPK1 |
0.771 | 0.215 | -3 | 0.854 |
CK1E |
0.771 | 0.001 | -3 | 0.567 |
PINK1 |
0.770 | -0.100 | 1 | 0.517 |
MPSK1 |
0.770 | 0.030 | 1 | 0.494 |
DAPK1 |
0.769 | 0.129 | -3 | 0.869 |
PRP4 |
0.769 | -0.007 | -3 | 0.729 |
PKG1 |
0.768 | 0.149 | -2 | 0.636 |
PAK4 |
0.767 | 0.064 | -2 | 0.669 |
BUB1 |
0.766 | 0.093 | -5 | 0.834 |
TAO1 |
0.766 | 0.206 | 1 | 0.618 |
NEK1 |
0.766 | 0.119 | 1 | 0.580 |
LRRK2 |
0.766 | 0.117 | 2 | 0.792 |
GRK2 |
0.765 | -0.092 | -2 | 0.712 |
TAK1 |
0.765 | 0.156 | 1 | 0.632 |
GAK |
0.764 | -0.009 | 1 | 0.535 |
LKB1 |
0.764 | -0.014 | -3 | 0.767 |
CAMKK1 |
0.763 | -0.053 | -2 | 0.780 |
CK1D |
0.763 | 0.013 | -3 | 0.519 |
RIPK2 |
0.763 | -0.025 | 1 | 0.595 |
NEK3 |
0.763 | 0.088 | 1 | 0.593 |
P38D |
0.762 | -0.028 | 1 | 0.382 |
GSK3B |
0.761 | 0.008 | 4 | 0.464 |
GSK3A |
0.761 | 0.011 | 4 | 0.473 |
CAMKK2 |
0.761 | -0.035 | -2 | 0.767 |
IRAK1 |
0.759 | -0.105 | -1 | 0.599 |
TTBK1 |
0.758 | -0.079 | 2 | 0.532 |
CK1A2 |
0.757 | 0.003 | -3 | 0.527 |
MYO3B |
0.757 | 0.182 | 2 | 0.796 |
PBK |
0.756 | 0.009 | 1 | 0.494 |
HASPIN |
0.755 | 0.040 | -1 | 0.596 |
MYO3A |
0.754 | 0.218 | 1 | 0.619 |
OSR1 |
0.754 | 0.066 | 2 | 0.756 |
STK33 |
0.752 | -0.069 | 2 | 0.546 |
VRK1 |
0.751 | -0.076 | 2 | 0.725 |
PLK2 |
0.750 | -0.045 | -3 | 0.690 |
JNK1 |
0.750 | -0.048 | 1 | 0.422 |
MEK2 |
0.750 | -0.031 | 2 | 0.721 |
GRK3 |
0.749 | -0.091 | -2 | 0.668 |
CK2A2 |
0.749 | -0.061 | 1 | 0.414 |
TTK |
0.747 | 0.034 | -2 | 0.884 |
ASK1 |
0.745 | 0.049 | 1 | 0.597 |
BIKE |
0.744 | -0.015 | 1 | 0.442 |
PDHK3_TYR |
0.742 | 0.076 | 4 | 0.875 |
TESK1_TYR |
0.741 | 0.062 | 3 | 0.874 |
NEK10_TYR |
0.740 | 0.196 | 1 | 0.597 |
CK2A1 |
0.740 | -0.070 | 1 | 0.408 |
PDHK4_TYR |
0.737 | 0.021 | 2 | 0.833 |
MAP2K4_TYR |
0.737 | 0.080 | -1 | 0.769 |
AAK1 |
0.736 | 0.018 | 1 | 0.373 |
LIMK2_TYR |
0.736 | 0.070 | -3 | 0.841 |
TYK2 |
0.735 | 0.147 | 1 | 0.615 |
PINK1_TYR |
0.735 | 0.027 | 1 | 0.566 |
PKMYT1_TYR |
0.735 | 0.056 | 3 | 0.835 |
MAP2K6_TYR |
0.734 | 0.002 | -1 | 0.765 |
RET |
0.734 | 0.072 | 1 | 0.607 |
MAP2K7_TYR |
0.733 | 0.017 | 2 | 0.788 |
YANK3 |
0.732 | -0.034 | 2 | 0.359 |
JAK1 |
0.730 | 0.166 | 1 | 0.632 |
STLK3 |
0.730 | -0.022 | 1 | 0.600 |
BMPR2_TYR |
0.730 | 0.001 | -1 | 0.739 |
TNNI3K_TYR |
0.729 | 0.097 | 1 | 0.560 |
LIMK1_TYR |
0.728 | -0.015 | 2 | 0.787 |
PDHK1_TYR |
0.728 | -0.068 | -1 | 0.747 |
ROS1 |
0.727 | 0.035 | 3 | 0.781 |
JAK2 |
0.726 | 0.040 | 1 | 0.618 |
MST1R |
0.725 | -0.002 | 3 | 0.787 |
JAK3 |
0.725 | -0.025 | 1 | 0.580 |
ALPHAK3 |
0.725 | -0.110 | -1 | 0.639 |
CK1A |
0.723 | -0.028 | -3 | 0.440 |
INSRR |
0.721 | -0.024 | 3 | 0.727 |
TYRO3 |
0.720 | -0.093 | 3 | 0.805 |
CSF1R |
0.720 | -0.045 | 3 | 0.764 |
TNK1 |
0.719 | 0.018 | 3 | 0.783 |
PDGFRB |
0.718 | -0.053 | 3 | 0.794 |
ABL2 |
0.718 | -0.052 | -1 | 0.638 |
FLT3 |
0.718 | -0.018 | 3 | 0.796 |
FGR |
0.717 | -0.100 | 1 | 0.557 |
DDR1 |
0.717 | -0.105 | 4 | 0.804 |
EPHA6 |
0.715 | -0.099 | -1 | 0.684 |
EPHB4 |
0.714 | -0.116 | -1 | 0.673 |
KDR |
0.713 | -0.049 | 3 | 0.719 |
CK1G3 |
0.713 | 0.019 | -3 | 0.397 |
TXK |
0.712 | -0.087 | 1 | 0.518 |
PDGFRA |
0.712 | -0.051 | 3 | 0.795 |
FGFR2 |
0.712 | -0.105 | 3 | 0.741 |
ABL1 |
0.711 | -0.085 | -1 | 0.628 |
YES1 |
0.711 | -0.127 | -1 | 0.657 |
WEE1_TYR |
0.710 | -0.025 | -1 | 0.593 |
LCK |
0.709 | -0.076 | -1 | 0.614 |
KIT |
0.709 | -0.100 | 3 | 0.759 |
TNK2 |
0.708 | -0.101 | 3 | 0.696 |
DDR2 |
0.708 | -0.018 | 3 | 0.685 |
HCK |
0.708 | -0.125 | -1 | 0.621 |
FGFR1 |
0.707 | -0.123 | 3 | 0.731 |
ITK |
0.707 | -0.120 | -1 | 0.602 |
FLT1 |
0.705 | -0.083 | -1 | 0.684 |
FER |
0.704 | -0.208 | 1 | 0.551 |
AXL |
0.704 | -0.135 | 3 | 0.735 |
TEK |
0.703 | -0.139 | 3 | 0.713 |
BLK |
0.703 | -0.099 | -1 | 0.627 |
TEC |
0.703 | -0.099 | -1 | 0.545 |
ALK |
0.703 | -0.093 | 3 | 0.698 |
INSR |
0.703 | -0.100 | 3 | 0.716 |
NTRK1 |
0.702 | -0.129 | -1 | 0.682 |
BTK |
0.702 | -0.128 | -1 | 0.572 |
EPHA4 |
0.702 | -0.128 | 2 | 0.698 |
EPHB1 |
0.702 | -0.163 | 1 | 0.565 |
BMX |
0.702 | -0.099 | -1 | 0.530 |
ERBB2 |
0.702 | -0.101 | 1 | 0.575 |
FLT4 |
0.702 | -0.104 | 3 | 0.713 |
MET |
0.701 | -0.138 | 3 | 0.741 |
EPHB3 |
0.701 | -0.162 | -1 | 0.644 |
NTRK2 |
0.700 | -0.141 | 3 | 0.726 |
MERTK |
0.700 | -0.154 | 3 | 0.728 |
LTK |
0.700 | -0.108 | 3 | 0.705 |
SRMS |
0.700 | -0.186 | 1 | 0.550 |
FGFR3 |
0.699 | -0.133 | 3 | 0.710 |
EPHB2 |
0.697 | -0.166 | -1 | 0.642 |
EPHA1 |
0.695 | -0.120 | 3 | 0.717 |
FRK |
0.695 | -0.115 | -1 | 0.633 |
PTK6 |
0.695 | -0.173 | -1 | 0.542 |
NTRK3 |
0.694 | -0.151 | -1 | 0.633 |
EGFR |
0.694 | -0.097 | 1 | 0.497 |
YANK2 |
0.694 | -0.068 | 2 | 0.381 |
EPHA3 |
0.693 | -0.141 | 2 | 0.667 |
FYN |
0.693 | -0.122 | -1 | 0.588 |
EPHA7 |
0.692 | -0.141 | 2 | 0.696 |
MUSK |
0.691 | -0.103 | 1 | 0.498 |
LYN |
0.690 | -0.142 | 3 | 0.711 |
MATK |
0.689 | -0.136 | -1 | 0.578 |
EPHA5 |
0.688 | -0.134 | 2 | 0.677 |
FGFR4 |
0.687 | -0.104 | -1 | 0.614 |
IGF1R |
0.686 | -0.112 | 3 | 0.653 |
PTK2 |
0.683 | -0.086 | -1 | 0.638 |
CSK |
0.683 | -0.156 | 2 | 0.691 |
PTK2B |
0.682 | -0.185 | -1 | 0.578 |
SYK |
0.682 | -0.095 | -1 | 0.610 |
SRC |
0.682 | -0.168 | -1 | 0.592 |
EPHA8 |
0.682 | -0.162 | -1 | 0.607 |
CK1G2 |
0.679 | -0.044 | -3 | 0.477 |
ERBB4 |
0.676 | -0.111 | 1 | 0.483 |
EPHA2 |
0.674 | -0.149 | -1 | 0.598 |
ZAP70 |
0.667 | -0.090 | -1 | 0.553 |
FES |
0.652 | -0.216 | -1 | 0.506 |