Motif 845 (n=169)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0J9YVX5 | None | S39 | ochoa | Golgi-associated PDZ and coiled-coil motif-containing protein (CFTR-associated ligand) (PDZ protein interacting specifically with TC10) | None |
| A0A0U1RQJ8 | ATRIP | S325 | ochoa | ATR interacting protein | None |
| A6NKF1 | SAC3D1 | S210 | ochoa | SAC3 domain-containing protein 1 (SAC3 homology domain-containing protein 1) | Involved in centrosome duplication and mitotic progression. {ECO:0000250}. |
| A6NKT7 | RGPD3 | S395 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| A8K0Z3 | WASHC1 | S345 | ochoa | WASH complex subunit 1 (CXYorf1-like protein on chromosome 9) (Protein FAM39E) (WAS protein family homolog 1) | Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:19922874, PubMed:19922875, PubMed:20498093, PubMed:23452853). Involved in endocytic trafficking of EGF (By similarity). Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration (PubMed:22114305). In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation (By similarity). Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling. Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex (PubMed:24344185). Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity). {ECO:0000250|UniProtKB:C4AMC7, ECO:0000250|UniProtKB:Q8VDD8, ECO:0000269|PubMed:19922874, ECO:0000269|PubMed:19922875, ECO:0000269|PubMed:20498093, ECO:0000269|PubMed:22114305, ECO:0000269|PubMed:23452853, ECO:0000305|PubMed:20498093}. |
| A8MWX3 | WASH4P | S358 | ochoa | Putative WAS protein family homolog 4 (Protein FAM39CP) | May act as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. {ECO:0000250|UniProtKB:A8K0Z3, ECO:0000250|UniProtKB:C4AMC7}. |
| C4AMC7 | WASH3P | S343 | ochoa | Putative WAS protein family homolog 3 (Protein FAM39DP) | Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:18159949, PubMed:20175130). Involved in endocytic trafficking of EGF (PubMed:20175130). Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration (By similarity). In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation. Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling (By similarity). Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex (By similarity). Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity). {ECO:0000250|UniProtKB:A8K0Z3, ECO:0000250|UniProtKB:Q8VDD8, ECO:0000269|PubMed:18159949, ECO:0000269|PubMed:20175130}. |
| C9J069 | AJM1 | S512 | ochoa | Apical junction component 1 homolog | May be involved in the control of adherens junction integrity. {ECO:0000250|UniProtKB:A0A1C3NSL9}. |
| E9PCH4 | None | S1464 | ochoa | Rap guanine nucleotide exchange factor 6 | None |
| O14639 | ABLIM1 | S655 | ochoa | Actin-binding LIM protein 1 (abLIM-1) (Actin-binding LIM protein family member 1) (Actin-binding double zinc finger protein) (LIMAB1) (Limatin) | May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance. {ECO:0000250, ECO:0000269|PubMed:9245787}. |
| O14686 | KMT2D | S31 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O14795 | UNC13B | S301 | ochoa | Protein unc-13 homolog B (Munc13-2) (munc13) | Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP) (By similarity). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity). In collaboration with UNC13A, facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (By similarity). {ECO:0000250|UniProtKB:Q9Z1N9}. |
| O14939 | PLD2 | S146 | psp | Phospholipase D2 (PLD 2) (hPLD2) (EC 3.1.4.4) (Choline phosphatase 2) (PLD1C) (Phosphatidylcholine-hydrolyzing phospholipase D2) | Function as phospholipase selective for phosphatidylcholine (PubMed:9582313). May have a role in signal-induced cytoskeletal regulation and/or endocytosis (By similarity). {ECO:0000250|UniProtKB:P97813, ECO:0000269|PubMed:9582313}. |
| O15503 | INSIG1 | S46 | psp | Insulin-induced gene 1 protein (INSIG-1) | Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR (PubMed:12202038, PubMed:12535518, PubMed:16168377, PubMed:16399501, PubMed:16606821, PubMed:32322062). Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:12202038, PubMed:16399501, PubMed:26311497, PubMed:32322062). Binds oxysterol, including 25-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum (PubMed:32322062). In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBF1/SREBP1 and SREBF2/SREBP2 to the Golgi (PubMed:15899885, PubMed:32322062). Sterol deprivation or phosphorylation by PCK1 reduce oxysterol-binding, disrupting the interaction between INSIG1 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:26311497, PubMed:32322062). Also regulates cholesterol synthesis by regulating degradation of HMGCR: initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligases AMFR/gp78 and/or RNF139 (PubMed:12535518, PubMed:16168377, PubMed:22143767). Also regulates degradation of SOAT2/ACAT2 when the lipid levels are low: initiates the ubiquitin-mediated degradation of SOAT2/ACAT2 via recruitment of the ubiquitin ligases AMFR/gp78 (PubMed:28604676). {ECO:0000269|PubMed:12202038, ECO:0000269|PubMed:12535518, ECO:0000269|PubMed:15899885, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:16399501, ECO:0000269|PubMed:16606821, ECO:0000269|PubMed:22143767, ECO:0000269|PubMed:26311497, ECO:0000269|PubMed:28604676, ECO:0000269|PubMed:32322062}. |
| O43166 | SIPA1L1 | S211 | ochoa | Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) | Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}. |
| O43182 | ARHGAP6 | S37 | ochoa | Rho GTPase-activating protein 6 (Rho-type GTPase-activating protein 6) (Rho-type GTPase-activating protein RhoGAPX-1) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology. {ECO:0000269|PubMed:10699171}. |
| O43379 | WDR62 | S1270 | ochoa | WD repeat-containing protein 62 | Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (PubMed:20729831, PubMed:20890278). Plays a role in mother-centriole-dependent centriole duplication; the function also seems to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). {ECO:0000269|PubMed:20729831, ECO:0000269|PubMed:20890278, ECO:0000269|PubMed:26297806}. |
| O43900 | PRICKLE3 | S594 | ochoa | Prickle planar cell polarity protein 3 (LIM domain only protein 6) (LMO-6) (Prickle-like protein 3) (Pk3) (Triple LIM domain protein 6) | Involved in the planar cell polarity (PCP) pathway that is essential for the polarization of epithelial cells during morphogenetic processes, including gastrulation and neurulation (By similarity). PCP is maintained by two molecular modules, the global and the core modules, PRICKLE3 being part of the core module (By similarity). Distinct complexes of the core module segregate to opposite sides of the cell, where they interact with the opposite complex in the neighboring cell at or near the adherents junctions (By similarity). Involved in the organization of the basal body (By similarity). Involved in cilia growth and positioning (By similarity). Required for proper assembly, stability, and function of mitochondrial membrane ATP synthase (mitochondrial complex V) (PubMed:32516135). {ECO:0000250|UniProtKB:A8WH69, ECO:0000269|PubMed:32516135}. |
| O60269 | GPRIN2 | S427 | ochoa | G protein-regulated inducer of neurite outgrowth 2 (GRIN2) | May be involved in neurite outgrowth. {ECO:0000269|PubMed:10480904}. |
| O60292 | SIPA1L3 | S1385 | ochoa | Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) | Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269|PubMed:26231217}. |
| O75533 | SF3B1 | S75 | ochoa | Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B1 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). {ECO:0000250|UniProtKB:Q99NB9, ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}. |
| O75691 | UTP20 | S1732 | ochoa | Small subunit processome component 20 homolog (Down-regulated in metastasis protein) (Novel nucleolar protein 73) (NNP73) (Protein Key-1A6) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in 18S pre-rRNA processing. Associates with U3 snoRNA. {ECO:0000269|PubMed:17498821, ECO:0000269|PubMed:34516797}. |
| O94819 | KBTBD11 | S510 | ochoa | Kelch repeat and BTB domain-containing protein 11 (Chronic myelogenous leukemia-associated protein) (Kelch domain-containing protein 7B) | None |
| O95359 | TACC2 | S1313 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| O95714 | HERC2 | S2942 | ochoa | E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2) | E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). Also modulates iron metabolism by regulating the basal turnover of FBXL5 (PubMed:24778179). {ECO:0000269|PubMed:20023648, ECO:0000269|PubMed:20304803, ECO:0000269|PubMed:22508508, ECO:0000269|PubMed:24778179, ECO:0000269|PubMed:26692333}. |
| P00519 | ABL1 | S855 | ochoa | Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150) | Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9 (PubMed:22810897). Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 also acts as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner (By similarity). Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity). {ECO:0000250|UniProtKB:P00520, ECO:0000269|PubMed:10391250, ECO:0000269|PubMed:11971963, ECO:0000269|PubMed:12379650, ECO:0000269|PubMed:12531427, ECO:0000269|PubMed:12672821, ECO:0000269|PubMed:15031292, ECO:0000269|PubMed:15556646, ECO:0000269|PubMed:15657060, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16424036, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:16943190, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:17623672, ECO:0000269|PubMed:18328268, ECO:0000269|PubMed:18945674, ECO:0000269|PubMed:19891780, ECO:0000269|PubMed:20357770, ECO:0000269|PubMed:20417104, ECO:0000269|PubMed:22810897, ECO:0000269|PubMed:28428613, ECO:0000269|PubMed:9037071, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9461559}. |
| P00558 | PGK1 | S364 | ochoa | Phosphoglycerate kinase 1 (EC 2.7.11.1) (EC 2.7.2.3) (Cell migration-inducing gene 10 protein) (Primer recognition protein 2) (PRP 2) | Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate (PubMed:30323285, PubMed:7391028). Both L- and D- forms of purine and pyrimidine nucleotides can be used as substrates, but the activity is much lower on pyrimidines (PubMed:18463139). In addition to its role as a glycolytic enzyme, it seems that PGK1 acts as a polymerase alpha cofactor protein (primer recognition protein) (PubMed:2324090). Acts as a protein kinase when localized to the mitochondrion where it phosphorylates pyruvate dehydrogenase kinase PDK1 to inhibit pyruvate dehydrogenase complex activity and suppress the formation of acetyl-coenzyme A from pyruvate, and consequently inhibit oxidative phosphorylation and promote glycolysis (PubMed:26942675, PubMed:36849569). May play a role in sperm motility (PubMed:26677959). {ECO:0000269|PubMed:18463139, ECO:0000269|PubMed:2324090, ECO:0000269|PubMed:26677959, ECO:0000269|PubMed:26942675, ECO:0000269|PubMed:30323285, ECO:0000269|PubMed:36849569, ECO:0000269|PubMed:7391028}. |
| P04406 | GAPDH | S83 | ochoa | Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (Peptidyl-cysteine S-nitrosylase GAPDH) (EC 2.6.99.-) | Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively (PubMed:11724794, PubMed:3170585). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (PubMed:11724794, PubMed:3170585). Modulates the organization and assembly of the cytoskeleton (By similarity). Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes (PubMed:23071094). Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (PubMed:23071094). Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (PubMed:23332158, PubMed:27387501). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis (By similarity). Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity). {ECO:0000250|UniProtKB:P04797, ECO:0000269|PubMed:11724794, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23332158, ECO:0000269|PubMed:27387501, ECO:0000269|PubMed:3170585}. |
| P06732 | CKM | S285 | ochoa | Creatine kinase M-type (EC 2.7.3.2) (Creatine kinase M chain) (Creatine phosphokinase M-type) (CPK-M) (M-CK) | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. {ECO:0000250|UniProtKB:P00563}. |
| P0C0S5 | H2AZ1 | S99 | ochoa | Histone H2A.Z (H2A/z) | Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division. {ECO:0000269|PubMed:15878876}. |
| P10070 | GLI2 | S866 | ochoa | Zinc finger protein GLI2 (GLI family zinc finger protein 2) (Tax helper protein) | Functions as a transcription regulator in the hedgehog (Hh) pathway (PubMed:18455992, PubMed:26565916). Functions as a transcriptional activator (PubMed:19878745, PubMed:24311597, PubMed:9557682). May also function as transcriptional repressor (By similarity). Requires STK36 for full transcriptional activator activity. Required for normal embryonic development (PubMed:15994174, PubMed:20685856). {ECO:0000250|UniProtKB:Q0VGT2, ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:18455992, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:26565916, ECO:0000269|PubMed:9557682, ECO:0000305|PubMed:20685856}.; FUNCTION: [Isoform 1]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 2]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 3]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 4]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 1]: Acts as a transcriptional activator in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 2]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 3]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 4]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 5]: Acts as a transcriptional repressor. {ECO:0000269|PubMed:15994174}. |
| P11413 | G6PD | S123 | ochoa | Glucose-6-phosphate 1-dehydrogenase (G6PD) (EC 1.1.1.49) | Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis. {ECO:0000269|PubMed:15858258, ECO:0000269|PubMed:24769394, ECO:0000269|PubMed:26479991, ECO:0000269|PubMed:35122041, ECO:0000269|PubMed:38066190, ECO:0000269|PubMed:743300}. |
| P17275 | JUNB | S49 | ochoa | Transcription factor JunB (Transcription factor AP-1 subunit JunB) | Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[GC]TCA-3'. Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to an AP-1 consensus sequence and its transcriptional activity (By similarity). {ECO:0000250|UniProtKB:P09450}. |
| P19338 | NCL | S460 | ochoa | Nucleolin (Protein C23) | Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. {ECO:0000269|PubMed:10393184}. |
| P20701 | ITGAL | S1145 | ochoa | Integrin alpha-L (CD11 antigen-like family member A) (Leukocyte adhesion glycoprotein LFA-1 alpha chain) (LFA-1A) (Leukocyte function-associated molecule 1 alpha chain) (CD antigen CD11a) | Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R (PubMed:11812992, PubMed:15528364). Integrin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL (PubMed:29100055). Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992). Acts as a platform at the immunological synapse to translate TCR engagement and density of the ITGAL ligand ICAM1 into graded adhesion (PubMed:38195629). Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis (By similarity). Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590). {ECO:0000250|UniProtKB:P24063, ECO:0000269|PubMed:11812992, ECO:0000269|PubMed:15356110, ECO:0000269|PubMed:15528364, ECO:0000269|PubMed:23775590, ECO:0000269|PubMed:29100055, ECO:0000269|PubMed:38195629}. |
| P22681 | CBL | S441 | ochoa | E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL) | E3 ubiquitin-protein ligase that acts as a negative regulator of many signaling pathways by mediating ubiquitination of cell surface receptors (PubMed:10514377, PubMed:11896602, PubMed:14661060, PubMed:14739300, PubMed:15190072, PubMed:17509076, PubMed:18374639, PubMed:19689429, PubMed:21596750, PubMed:28381567). Accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome (PubMed:10514377, PubMed:14661060, PubMed:14739300, PubMed:17094949, PubMed:17509076, PubMed:17974561). Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, CSF1R, EPHA8 and KDR and mediates their ubiquitination to terminate signaling (PubMed:15190072, PubMed:18374639, PubMed:21596750). Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation (PubMed:11896602). Ubiquitinates EGFR and SPRY2 (PubMed:17094949, PubMed:17974561). Ubiquitinates NECTIN1 following association between NECTIN1 and herpes simplex virus 1/HHV-1 envelope glycoprotein D, leading to NECTIN1 removal from cell surface (PubMed:28381567). Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis (PubMed:15190072, PubMed:18374639). Essential for osteoclastic bone resorption (PubMed:14739300). The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:14739300). May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBLB, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity). {ECO:0000250|UniProtKB:P22682, ECO:0000269|PubMed:10514377, ECO:0000269|PubMed:11896602, ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:14739300, ECO:0000269|PubMed:15190072, ECO:0000269|PubMed:17094949, ECO:0000269|PubMed:17509076, ECO:0000269|PubMed:17974561, ECO:0000269|PubMed:18374639, ECO:0000269|PubMed:19689429, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:28381567}. |
| P23396 | RPS3 | S104 | ochoa | Small ribosomal subunit protein uS3 (40S ribosomal protein S3) (EC 4.2.99.18) | Component of the small ribosomal subunit (PubMed:23636399, PubMed:8706699). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:8706699). Has endonuclease activity and plays a role in repair of damaged DNA (PubMed:7775413). Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (PubMed:15707971). Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (PubMed:14706345). Has also been shown to bind with similar affinity to intact and damaged DNA (PubMed:18610840). Stimulates the N-glycosylase activity of the base excision protein OGG1 (PubMed:15518571). Enhances the uracil excision activity of UNG1 (PubMed:18973764). Also stimulates the cleavage of the phosphodiester backbone by APEX1 (PubMed:18973764). When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage (PubMed:23911537). Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide (PubMed:17049931). Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes (PubMed:18045535). Represses its own translation by binding to its cognate mRNA (PubMed:20217897). Binds to and protects TP53/p53 from MDM2-mediated ubiquitination (PubMed:19656744). Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization (PubMed:23131551). Involved in induction of apoptosis through its role in activation of CASP8 (PubMed:14988002). Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5 (PubMed:20605787). Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation (PubMed:22510408). {ECO:0000269|PubMed:14706345, ECO:0000269|PubMed:14988002, ECO:0000269|PubMed:15518571, ECO:0000269|PubMed:15707971, ECO:0000269|PubMed:17049931, ECO:0000269|PubMed:18045535, ECO:0000269|PubMed:18610840, ECO:0000269|PubMed:18973764, ECO:0000269|PubMed:19656744, ECO:0000269|PubMed:20217897, ECO:0000269|PubMed:20605787, ECO:0000269|PubMed:22510408, ECO:0000269|PubMed:23131551, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:23911537, ECO:0000269|PubMed:7775413, ECO:0000269|PubMed:8706699}. |
| P27815 | PDE4A | S830 | ochoa | 3',5'-cyclic-AMP phosphodiesterase 4A (EC 3.1.4.53) (DPDE2) (PDE46) (cAMP-specific phosphodiesterase 4A) | Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:11566027, ECO:0000269|PubMed:2160582}.; FUNCTION: [Isoform 1]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310}.; FUNCTION: [Isoform 2]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:15738310}.; FUNCTION: [Isoform 3]: Efficiently hydrolyzes cAMP. The phosphodiesterase activity is not affected by calcium, calmodulin or cyclic GMP (cGMP) levels. Does not hydrolyze cGMP. {ECO:0000269|PubMed:7888306}.; FUNCTION: [Isoform 4]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:9677330}.; FUNCTION: [Isoform 6]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310, ECO:0000269|PubMed:17727341}.; FUNCTION: [Isoform 7]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:18095939}. |
| P28482 | MAPK1 | S29 | psp | Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade also plays a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1 and FXR1) and a variety of other signaling-related molecules (like ARHGEF2, DCC, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. Mediates phosphorylation of TPR in response to EGF stimulation. May play a role in the spindle assembly checkpoint. Phosphorylates PML and promotes its interaction with PIN1, leading to PML degradation. Phosphorylates CDK2AP2 (By similarity). Phosphorylates phosphoglycerate kinase PGK1 under hypoxic conditions to promote its targeting to the mitochondrion and suppress the formation of acetyl-coenzyme A from pyruvate (PubMed:26942675). {ECO:0000250|UniProtKB:P63086, ECO:0000269|PubMed:10617468, ECO:0000269|PubMed:10637505, ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:12110590, ECO:0000269|PubMed:12356731, ECO:0000269|PubMed:12792650, ECO:0000269|PubMed:12794087, ECO:0000269|PubMed:12974390, ECO:0000269|PubMed:15184391, ECO:0000269|PubMed:15241487, ECO:0000269|PubMed:15616583, ECO:0000269|PubMed:15664191, ECO:0000269|PubMed:15788397, ECO:0000269|PubMed:15952796, ECO:0000269|PubMed:16581800, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:19265199, ECO:0000269|PubMed:19879846, ECO:0000269|PubMed:22033920, ECO:0000269|PubMed:26942675, ECO:0000269|PubMed:32721402, ECO:0000269|PubMed:7588608, ECO:0000269|PubMed:8622688, ECO:0000269|PubMed:9480836, ECO:0000269|PubMed:9596579, ECO:0000269|PubMed:9649500, ECO:0000269|PubMed:9687510, ECO:0000303|PubMed:15526160, ECO:0000303|PubMed:16393692, ECO:0000303|PubMed:19565474, ECO:0000303|PubMed:21779493}.; FUNCTION: Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity. {ECO:0000269|PubMed:19879846}. |
| P30291 | WEE1 | S139 | ochoa|psp | Wee1-like protein kinase (WEE1hu) (EC 2.7.10.2) (Wee1A kinase) | Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15' (PubMed:15070733, PubMed:7743995, PubMed:8348613, PubMed:8428596). Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase (PubMed:7743995, PubMed:8348613, PubMed:8428596). Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur (PubMed:7743995, PubMed:8348613, PubMed:8428596). Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated (PubMed:7743995). A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation (PubMed:7743995). {ECO:0000269|PubMed:15070733, ECO:0000269|PubMed:7743995, ECO:0000269|PubMed:8348613, ECO:0000269|PubMed:8428596}. |
| P30533 | LRPAP1 | S137 | ochoa | Alpha-2-macroglobulin receptor-associated protein (Alpha-2-MRAP) (Low density lipoprotein receptor-related protein-associated protein 1) (RAP) | Molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway. {ECO:0000269|PubMed:32296178, ECO:0000269|PubMed:7774585}. |
| P31040 | SDHA | S456 | ochoa | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (EC 1.3.5.1) (Flavoprotein subunit of complex II) (Fp) (Malate dehydrogenase [quinone] flavoprotein subunit) (EC 1.1.5.-) | Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (PubMed:10746566, PubMed:24781757). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate (By similarity). Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate (By similarity). Can act as a tumor suppressor (PubMed:20484225). {ECO:0000250|UniProtKB:P31039, ECO:0000269|PubMed:10746566, ECO:0000269|PubMed:20484225, ECO:0000269|PubMed:24781757}. |
| P31943 | HNRNPH1 | S272 | ochoa | Heterogeneous nuclear ribonucleoprotein H (hnRNP H) [Cleaved into: Heterogeneous nuclear ribonucleoprotein H, N-terminally processed] | This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG). {ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:16946708}. |
| P33897 | ABCD1 | S58 | ochoa | ATP-binding cassette sub-family D member 1 (EC 3.1.2.-) (EC 7.6.2.-) (Adrenoleukodystrophy protein) (ALDP) | ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)-CoA from the cytosol to the peroxisome lumen (PubMed:11248239, PubMed:15682271, PubMed:16946495, PubMed:18757502, PubMed:21145416, PubMed:23671276, PubMed:29397936, PubMed:33500543). Coupled to the ATP-dependent transporter activity also has a fatty acyl-CoA thioesterase activity (ACOT) and hydrolyzes VLCFA-CoA into VLCFA prior their ATP-dependent transport into peroxisomes, the ACOT activity is essential during this transport process (PubMed:29397936, PubMed:33500543). Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation (PubMed:21145416, PubMed:23671276). Involved in several processes; namely, controls the active myelination phase by negatively regulating the microsomal fatty acid elongation activity and may also play a role in axon and myelin maintenance. Also controls the cellular response to oxidative stress by regulating mitochondrial functions such as mitochondrial oxidative phosphorylation and depolarization. And finally controls the inflammatory response by positively regulating peroxisomal beta-oxidation of VLCFAs (By similarity). {ECO:0000250|UniProtKB:P48410, ECO:0000269|PubMed:11248239, ECO:0000269|PubMed:15682271, ECO:0000269|PubMed:16946495, ECO:0000269|PubMed:18757502, ECO:0000269|PubMed:21145416, ECO:0000269|PubMed:23671276, ECO:0000269|PubMed:29397936, ECO:0000269|PubMed:33500543}. |
| P35221 | CTNNA1 | S268 | ochoa | Catenin alpha-1 (Alpha E-catenin) (Cadherin-associated protein) (Renal carcinoma antigen NY-REN-13) | Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). May play a crucial role in cell differentiation. {ECO:0000250|UniProtKB:P26231, ECO:0000269|PubMed:25653389}. |
| P35222 | CTNNB1 | S715 | ochoa|psp | Catenin beta-1 (Beta-catenin) | Key downstream component of the canonical Wnt signaling pathway (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). Also acts as a coactivator for other transcription factors, such as NR5A2 (PubMed:22187462). Promotes epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via driving transcription of CTNNB1/TCF-target genes (PubMed:29910125). Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (By similarity). Acts as a negative regulator of centrosome cohesion (PubMed:18086858). Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization (PubMed:21262353). Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (PubMed:18957423). Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity). Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, via promoting the transcription of differentiation factors such as LEF1, BMP2 and BMP4 (By similarity). Activity is repressed in a MSX1-mediated manner at the bell stage of mesenchymal tooth germ formation which prevents premature differentiation of odontoblasts (By similarity). {ECO:0000250|UniProtKB:Q02248, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:18077326, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18957423, ECO:0000269|PubMed:21262353, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22187462, ECO:0000269|PubMed:22647378, ECO:0000269|PubMed:22699938, ECO:0000269|PubMed:29910125}. |
| P36507 | MAP2K2 | S76 | ochoa | Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2) | Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (PubMed:29433126). {ECO:0000250|UniProtKB:Q63932, ECO:0000269|PubMed:29433126}. |
| P41180 | CASR | S895 | psp | Extracellular calcium-sensing receptor (CaR) (CaSR) (hCasR) (Parathyroid cell calcium-sensing receptor 1) (PCaR1) | G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis (PubMed:17555508, PubMed:19789209, PubMed:21566075, PubMed:22114145, PubMed:22789683, PubMed:23966241, PubMed:25104082, PubMed:25292184, PubMed:25766501, PubMed:26386835, PubMed:32817431, PubMed:33603117, PubMed:34194040, PubMed:34467854, PubMed:7759551, PubMed:8636323, PubMed:8702647, PubMed:8878438). Senses fluctuations in the circulating calcium concentration: activated by elevated circulating calcium, leading to decreased parathyroid hormone (PTH) secretion in parathyroid glands (By similarity). In kidneys, acts as a key regulator of renal tubular calcium resorption (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G-proteins) and modulates the activity of downstream effectors (PubMed:38632411). CASR is coupled with different G(q)/G(11), G(i)/G(o)- or G(s)-classes of G-proteins depending on the context (PubMed:38632411). In the parathyroid and kidney, CASR signals through G(q)/G(11) and G(i)/G(o) G-proteins: G(q)/G(11) coupling activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers, while G(i)/G(o) coupling mediates inhibition of adenylate cyclase activity (PubMed:38632411, PubMed:7759551). The G-protein-coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as Trp or Phe, act concertedly with divalent cations, such as calcium or magnesium, to achieve full receptor activation (PubMed:27386547, PubMed:27434672, PubMed:32817431, PubMed:33603117, PubMed:34194040). Acts as an activator of the NLRP3 inflammasome via G(i)/G(o)-mediated signaling: down-regulation of cyclic AMP (cAMP) relieving NLRP3 inhibition by cAMP (PubMed:32843625). Acts as a regulator of proton-sensing receptor GPR68 in a seesaw manner: CASR-mediated signaling inhibits GPR68 signaling in response to extracellular calcium, while GPR68 inhibits CASR in presence of extracellular protons (By similarity). {ECO:0000250|UniProtKB:P48442, ECO:0000250|UniProtKB:Q9QY96, ECO:0000269|PubMed:17555508, ECO:0000269|PubMed:19789209, ECO:0000269|PubMed:21566075, ECO:0000269|PubMed:22114145, ECO:0000269|PubMed:22789683, ECO:0000269|PubMed:23966241, ECO:0000269|PubMed:25104082, ECO:0000269|PubMed:25292184, ECO:0000269|PubMed:25766501, ECO:0000269|PubMed:26386835, ECO:0000269|PubMed:27386547, ECO:0000269|PubMed:27434672, ECO:0000269|PubMed:32817431, ECO:0000269|PubMed:32843625, ECO:0000269|PubMed:33603117, ECO:0000269|PubMed:34194040, ECO:0000269|PubMed:34467854, ECO:0000269|PubMed:38632411, ECO:0000269|PubMed:7759551, ECO:0000269|PubMed:8636323, ECO:0000269|PubMed:8702647, ECO:0000269|PubMed:8878438}. |
| P49321 | NASP | S680 | ochoa | Nuclear autoantigenic sperm protein (NASP) | Component of the histone chaperone network (PubMed:22195965). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:22195965). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000250|UniProtKB:Q99MD9, ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 1]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 2]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}. |
| P49792 | RANBP2 | S394 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P49959 | MRE11 | S561 | psp | Double-strand break repair protein MRE11 (EC 3.1.-.-) (Meiotic recombination 11 homolog 1) (MRE11 homolog 1) (Meiotic recombination 11 homolog A) (MRE11 homolog A) | Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:11741547, PubMed:14657032, PubMed:22078559, PubMed:23080121, PubMed:24316220, PubMed:26240375, PubMed:27889449, PubMed:28867292, PubMed:29670289, PubMed:30464262, PubMed:30612738, PubMed:31353207, PubMed:37696958, PubMed:38128537, PubMed:9590181, PubMed:9651580, PubMed:9705271). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (PubMed:24316220, PubMed:28867292, PubMed:31353207, PubMed:38128537). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (PubMed:24316220, PubMed:27889449, PubMed:28867292, PubMed:36050397, PubMed:38128537). Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity (PubMed:11741547, PubMed:22078559, PubMed:24316220, PubMed:26240375, PubMed:27889449, PubMed:29670289, PubMed:31353207, PubMed:36563124, PubMed:9590181, PubMed:9651580, PubMed:9705271). After DSBs, MRE11 is loaded onto DSBs sites and cleaves DNA by cooperating with RBBP8/CtIP to initiate end resection (PubMed:27814491, PubMed:27889449, PubMed:30787182). MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR (PubMed:24316220). It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation to create entry sites for EXO1- and DNA2-mediated 5' to 3' long-range resection, which is required for single-strand invasion and recombination (PubMed:24316220, PubMed:28867292). RBBP8/CtIP specifically promotes the endonuclease activity of MRE11 to clear protein-DNA adducts and generate clean double-strand break ends (PubMed:27814491, PubMed:27889449, PubMed:30787182). MRE11 endonuclease activity is also enhanced by AGER/RAGE (By similarity). The MRN complex is also required for DNA damage signaling via activation of the ATM and ATR kinases: the nuclease activity of MRE11 is not required to activate ATM and ATR (PubMed:14657032, PubMed:15064416, PubMed:15790808, PubMed:16622404). The MRN complex is also required for the processing of R-loops (PubMed:31537797). The MRN complex is involved in the activation of the cGAS-STING pathway induced by DNA damage during tumorigenesis: the MRN complex acts by displacing CGAS from nucleosome sequestration, thereby activating it (By similarity). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888). {ECO:0000250|UniProtKB:Q61216, ECO:0000269|PubMed:10888888, ECO:0000269|PubMed:11741547, ECO:0000269|PubMed:14657032, ECO:0000269|PubMed:15064416, ECO:0000269|PubMed:15790808, ECO:0000269|PubMed:16622404, ECO:0000269|PubMed:22078559, ECO:0000269|PubMed:23080121, ECO:0000269|PubMed:24316220, ECO:0000269|PubMed:26240375, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:28867292, ECO:0000269|PubMed:29670289, ECO:0000269|PubMed:30464262, ECO:0000269|PubMed:30612738, ECO:0000269|PubMed:30787182, ECO:0000269|PubMed:31353207, ECO:0000269|PubMed:31537797, ECO:0000269|PubMed:36050397, ECO:0000269|PubMed:36563124, ECO:0000269|PubMed:37696958, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9590181, ECO:0000269|PubMed:9651580, ECO:0000269|PubMed:9705271}.; FUNCTION: MRE11 contains two DNA-binding domains (DBDs), enabling it to bind both single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). {ECO:0000305}. |
| P51116 | FXR2 | S418 | ochoa | RNA-binding protein FXR2 (FXR2P) (FMR1 autosomal homolog 2) | mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for adult hippocampal neurogenesis (By similarity). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (By similarity). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs: mRNAs storage into membraneless compartments regulates their translation and/or stability (By similarity). Acts as a regulator of adult hippocampal neurogenesis by regulating translation and/or stability of NOG mRNA, thereby preventing NOG protein expression in the dentate gyrus (By similarity). {ECO:0000250|UniProtKB:Q61584, ECO:0000250|UniProtKB:Q9WVR4}. |
| P51825 | AFF1 | S620 | ochoa | AF4/FMR2 family member 1 (ALL1-fused gene from chromosome 4 protein) (Protein AF-4) (Protein FEL) (Proto-oncogene AF4) | None |
| P53985 | SLC16A1 | S213 | ochoa | Monocarboxylate transporter 1 (MCT 1) (Solute carrier family 16 member 1) | Bidirectional proton-coupled monocarboxylate transporter (PubMed:12946269, PubMed:32946811, PubMed:33333023). Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, acetate and the ketone bodies acetoacetate and beta-hydroxybutyrate, and thus contributes to the maintenance of intracellular pH (PubMed:12946269, PubMed:33333023). The transport direction is determined by the proton motive force and the concentration gradient of the substrate monocarboxylate. MCT1 is a major lactate exporter (By similarity). Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis (By similarity). Facilitates the protonated monocarboxylate form of succinate export, that its transient protonation upon muscle cell acidification in exercising muscle and ischemic heart (PubMed:32946811). Functions via alternate outward- and inward-open conformation states. Protonation and deprotonation of 309-Asp is essential for the conformational transition (PubMed:33333023). {ECO:0000250|UniProtKB:P53986, ECO:0000250|UniProtKB:P53987, ECO:0000269|PubMed:12946269, ECO:0000269|PubMed:32946811, ECO:0000269|PubMed:33333023}. |
| P55201 | BRPF1 | S867 | ochoa | Peregrin (Bromodomain and PHD finger-containing protein 1) (Protein Br140) | Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:24065767, PubMed:27939640). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac) (PubMed:24065767). Some HAT complexes preferentially mediate histone H3 'Lys-23' (H3K23ac) acetylation (PubMed:27939640). Positively regulates the transcription of RUNX1 and RUNX2 (PubMed:18794358). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:18794358, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:27939640}. |
| P55795 | HNRNPH2 | S272 | ochoa | Heterogeneous nuclear ribonucleoprotein H2 (hnRNP H2) (FTP-3) (Heterogeneous nuclear ribonucleoprotein H') (hnRNP H') [Cleaved into: Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed] | This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG). |
| P60709 | ACTB | S235 | ochoa | Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] | Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (PubMed:39321809, PubMed:38609661). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:Q6QAQ1, ECO:0000269|PubMed:25255767, ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| P61019 | RAB2A | S70 | ochoa | Ras-related protein Rab-2A (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology (PubMed:37821429). RAB2A regulates autophagy by promoting autophagosome-lysosome fusion via recruitment of the HOPS endosomal tethering complex; this process involves autophagosomal RAB2A and lysosomal RAB39A recruitment of HOPS subcomplexes VPS39-VPS11 and VPS41-VPS16-VPS18-VPS33A, respectively, which assemble into a functional complex to mediate membrane tethering and SNAREs-driven membrane fusion (PubMed:37821429). Required for protein transport from the endoplasmic reticulum to the Golgi complex. Regulates the compacted morphology of the Golgi (PubMed:26209634). Together with RAB2B, redundantly required for efficient autophagic flux (PubMed:28483915). {ECO:0000269|PubMed:26209634, ECO:0000269|PubMed:28483915, ECO:0000269|PubMed:37821429}. |
| P62736 | ACTA2 | S237 | ochoa | Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P62879 | GNB2 | S28 | ochoa | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (G protein subunit beta-2) (Transducin beta chain 2) | Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. |
| P63261 | ACTG1 | S235 | ochoa | Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage (By similarity). {ECO:0000250|UniProtKB:P63260, ECO:0000305|PubMed:29581253}. |
| P63267 | ACTG2 | S236 | ochoa | Actin, gamma-enteric smooth muscle (EC 3.6.4.-) (Alpha-actin-3) (Gamma-2-actin) (Smooth muscle gamma-actin) [Cleaved into: Actin, gamma-enteric smooth muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P68032 | ACTC1 | S237 | ochoa | Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P68133 | ACTA1 | S237 | ochoa | Actin, alpha skeletal muscle (EC 3.6.4.-) (Alpha-actin-1) [Cleaved into: Actin, alpha skeletal muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P78369 | CLDN10 | S202 | ochoa | Claudin-10 (Oligodendrocyte-specific protein-like) (OSP-like) | Forms paracellular channels: polymerizes in tight junction strands with cation- and anion-selective channels through the strands, conveying epithelial permeability in a process known as paracellular tight junction permeability. {ECO:0000269|PubMed:19383724, ECO:0000269|PubMed:28686597, ECO:0000269|PubMed:35650657, ECO:0000269|PubMed:36008380}.; FUNCTION: [Isoform 1]: Forms cation-selective paracellular channels. In sweat glands and in the thick ascending limb (TAL) of Henle's loop in kidney, it controls paracellular sodium permeability which is essential for proper sweat production and renal function (PubMed:19383724, PubMed:28686597, PubMed:28771254, PubMed:35650657, PubMed:36008380). {ECO:0000269|PubMed:19383724, ECO:0000269|PubMed:28686597, ECO:0000269|PubMed:28771254, ECO:0000269|PubMed:35650657, ECO:0000269|PubMed:36008380}.; FUNCTION: [Isoform 2]: Forms anion-selective paracellular channels. In renal proximal tubules, it conveys selective chloride over hydrogencarbonate anion permeability which is required for renal chloride reabsorption and salt homeostasis. {ECO:0000250|UniProtKB:Q9Z0S6, ECO:0000269|PubMed:19383724, ECO:0000269|PubMed:36008380}. |
| Q02750 | MAP2K1 | S72 | ochoa|psp | Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1) | Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (PubMed:29433126). Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis. {ECO:0000269|PubMed:14737111, ECO:0000269|PubMed:17101779, ECO:0000269|PubMed:29433126}. |
| Q04637 | EIF4G1 | S1147 | ochoa|psp | Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:29987188). Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) (PubMed:29987188). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon (PubMed:29987188). Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning (PubMed:29987188). As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). {ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29987188}. |
| Q08495 | DMTN | S309 | ochoa | Dematin (Dematin actin-binding protein) (Erythrocyte membrane protein band 4.9) | Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Also plays a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation. {ECO:0000269|PubMed:10565303, ECO:0000269|PubMed:11856323, ECO:0000269|PubMed:18347014, ECO:0000269|PubMed:19241372, ECO:0000269|PubMed:22927433, ECO:0000269|PubMed:23355471}. |
| Q0VDD7 | BRME1 | S370 | ochoa | Break repair meiotic recombinase recruitment factor 1 (Pre-T/NK cell-associated protein 3B3) | Meiotic recombination factor component of recombination bridges involved in meiotic double-strand break repair. Modulates the localization of recombinases DMC1:RAD51 to meiotic double-strand break (DSB) sites through the interaction with and stabilization of the BRCA2:HSF2BP complex during meiotic recombination. Indispensable for the DSB repair, homologous synapsis, and crossover formation that are needed for progression past metaphase I, is essential for spermatogenesis and male fertility. {ECO:0000250|UniProtKB:Q6DIA7}. |
| Q12931 | TRAP1 | S194 | ochoa | Heat shock protein 75 kDa, mitochondrial (HSP 75) (Heat shock protein family C member 5) (TNFR-associated protein 1) (Tumor necrosis factor type 1 receptor-associated protein) (TRAP-1) | Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA. {ECO:0000269|PubMed:23525905, ECO:0000269|PubMed:23564345, ECO:0000269|PubMed:23747254}. |
| Q12955 | ANK3 | S896 | ochoa | Ankyrin-3 (ANK-3) (Ankyrin-G) | Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (PubMed:7836469). In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). {ECO:0000250|UniProtKB:G5E8K5, ECO:0000250|UniProtKB:O70511, ECO:0000269|PubMed:23903368, ECO:0000269|PubMed:7836469}.; FUNCTION: [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. {ECO:0000305|PubMed:17974005}. |
| Q13009 | TIAM1 | S1410 | ochoa | Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1) | Guanyl-nucleotide exchange factor that activates RHO-like proteins and connects extracellular signals to cytoskeletal activities. Activates RAC1, CDC42, and to a lesser extent RHOA and their downstream signaling to regulate processes like cell adhesion and cell migration. {ECO:0000269|PubMed:20361982, ECO:0000269|PubMed:25684205}. |
| Q13263 | TRIM28 | S102 | ochoa | Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28) | Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also a corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:Q62318, ECO:0000269|PubMed:10347202, ECO:0000269|PubMed:11959841, ECO:0000269|PubMed:15882967, ECO:0000269|PubMed:16107876, ECO:0000269|PubMed:16862143, ECO:0000269|PubMed:17079232, ECO:0000269|PubMed:17178852, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17942393, ECO:0000269|PubMed:18060868, ECO:0000269|PubMed:18082607, ECO:0000269|PubMed:20424263, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:21940674, ECO:0000269|PubMed:23543754, ECO:0000269|PubMed:23665872, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:8769649, ECO:0000269|PubMed:9016654}.; FUNCTION: (Microbial infection) Plays a critical role in the shutdown of lytic gene expression during the early stage of herpes virus 8 primary infection. This inhibition is mediated through interaction with herpes virus 8 protein LANA1. {ECO:0000269|PubMed:24741090}. |
| Q13263 | TRIM28 | S683 | ochoa | Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28) | Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also a corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:Q62318, ECO:0000269|PubMed:10347202, ECO:0000269|PubMed:11959841, ECO:0000269|PubMed:15882967, ECO:0000269|PubMed:16107876, ECO:0000269|PubMed:16862143, ECO:0000269|PubMed:17079232, ECO:0000269|PubMed:17178852, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17942393, ECO:0000269|PubMed:18060868, ECO:0000269|PubMed:18082607, ECO:0000269|PubMed:20424263, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:21940674, ECO:0000269|PubMed:23543754, ECO:0000269|PubMed:23665872, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:8769649, ECO:0000269|PubMed:9016654}.; FUNCTION: (Microbial infection) Plays a critical role in the shutdown of lytic gene expression during the early stage of herpes virus 8 primary infection. This inhibition is mediated through interaction with herpes virus 8 protein LANA1. {ECO:0000269|PubMed:24741090}. |
| Q13615 | MTMR3 | S647 | ochoa | Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3 (EC 3.1.3.95) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Myotubularin-related protein 3) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (Phosphatidylinositol-3-phosphate phosphatase) (Zinc finger FYVE domain-containing protein 10) | Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate (PubMed:10733931, PubMed:11302699, PubMed:11676921, PubMed:12646134). Decreases the levels of phosphatidylinositol 3-phosphate, a phospholipid found in cell membranes where it acts as key regulator of both cell signaling and intracellular membrane traffic (PubMed:11302699, PubMed:11676921, PubMed:12646134). Could also have a molecular sequestering/adapter activity and regulate biological processes independently of its phosphatase activity. It includes the regulation of midbody abscission during mitotic cytokinesis (PubMed:25659891). {ECO:0000269|PubMed:10733931, ECO:0000269|PubMed:11302699, ECO:0000269|PubMed:11676921, ECO:0000269|PubMed:12646134, ECO:0000269|PubMed:25659891}. |
| Q14526 | HIC1 | S713 | psp | Hypermethylated in cancer 1 protein (Hic-1) (Zinc finger and BTB domain-containing protein 29) | Transcriptional repressor (PubMed:12052894, PubMed:15231840). Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3' (PubMed:15231840). May act as a tumor suppressor (PubMed:20154726). Involved in development of head, face, limbs and ventral body wall (By similarity). Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses (PubMed:16269335). The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1 (PubMed:12052894, PubMed:20547755). In cooperation with MTA1 (indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells (PubMed:20547755). Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF-responsive genes (PubMed:16724116). Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex (PubMed:18347096, PubMed:19486893). Probably represses transcription of ACKR3, FGFBP1 and EFNA1 (PubMed:16690027, PubMed:19525223, PubMed:20154726). {ECO:0000250|UniProtKB:Q9R1Y5, ECO:0000269|PubMed:12052894, ECO:0000269|PubMed:15231840, ECO:0000269|PubMed:16269335, ECO:0000269|PubMed:16690027, ECO:0000269|PubMed:16724116, ECO:0000269|PubMed:18347096, ECO:0000269|PubMed:19486893, ECO:0000269|PubMed:19525223, ECO:0000269|PubMed:20154726, ECO:0000269|PubMed:20547755}. |
| Q14980 | NUMA1 | S1724 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q15653 | NFKBIB | S315 | psp | NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkB-B) (IkB-beta) (IkappaBbeta) (Thyroid receptor-interacting protein 9) (TR-interacting protein 9) (TRIP-9) | Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation. |
| Q15654 | TRIP6 | S102 | ochoa | Thyroid receptor-interacting protein 6 (TR-interacting protein 6) (TRIP-6) (Opa-interacting protein 1) (OIP-1) (Zyxin-related protein 1) (ZRP-1) | Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor. {ECO:0000269|PubMed:14688263, ECO:0000269|PubMed:15489293, ECO:0000269|PubMed:16624523, ECO:0000269|PubMed:19017743}. |
| Q15699 | ALX1 | S39 | ochoa | ALX homeobox protein 1 (Cartilage homeoprotein 1) (CART-1) | Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes (PubMed:8756334, PubMed:9753625). Most probably regulates the expression of genes involved in the development of mesenchyme-derived craniofacial structures. Early on in development, it plays a role in forebrain mesenchyme survival (PubMed:20451171). May also induce epithelial to mesenchymal transition (EMT) through the expression of SNAI1 (PubMed:23288509). {ECO:0000269|PubMed:20451171, ECO:0000269|PubMed:23288509, ECO:0000269|PubMed:8756334, ECO:0000269|PubMed:9753625}. |
| Q16665 | HIF1A | S727 | psp | Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8) | Functions as a master transcriptional regulator of the adaptive response to hypoxia (PubMed:11292861, PubMed:11566883, PubMed:15465032, PubMed:16973622, PubMed:17610843, PubMed:18658046, PubMed:20624928, PubMed:22009797, PubMed:30125331, PubMed:9887100). Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia (PubMed:11292861, PubMed:11566883, PubMed:15465032, PubMed:16973622, PubMed:17610843, PubMed:20624928, PubMed:22009797, PubMed:30125331, PubMed:9887100). Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease (PubMed:22009797). Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300 (PubMed:16543236, PubMed:9887100). Activity is enhanced by interaction with NCOA1 and/or NCOA2 (PubMed:10594042). Interaction with redox regulatory protein APEX1 seems to activate CTAD and potentiates activation by NCOA1 and CREBBP (PubMed:10202154, PubMed:10594042). Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia (PubMed:19528298). {ECO:0000250|UniProtKB:Q61221, ECO:0000269|PubMed:10202154, ECO:0000269|PubMed:10594042, ECO:0000269|PubMed:11292861, ECO:0000269|PubMed:11566883, ECO:0000269|PubMed:15465032, ECO:0000269|PubMed:16543236, ECO:0000269|PubMed:16973622, ECO:0000269|PubMed:17610843, ECO:0000269|PubMed:18658046, ECO:0000269|PubMed:19528298, ECO:0000269|PubMed:20624928, ECO:0000269|PubMed:22009797, ECO:0000269|PubMed:30125331, ECO:0000269|PubMed:9887100}.; FUNCTION: (Microbial infection) Upon infection by human coronavirus SARS-CoV-2, is required for induction of glycolysis in monocytes and the consequent pro-inflammatory state (PubMed:32697943). In monocytes, induces expression of ACE2 and cytokines such as IL1B, TNF, IL6, and interferons (PubMed:32697943). Promotes human coronavirus SARS-CoV-2 replication and monocyte inflammatory response (PubMed:32697943). {ECO:0000269|PubMed:32697943}. |
| Q53ET0 | CRTC2 | S70 | ochoa | CREB-regulated transcription coactivator 2 (Transducer of regulated cAMP response element-binding protein 2) (TORC-2) (Transducer of CREB protein 2) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:14536081, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:16809310, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223}. |
| Q5JSL3 | DOCK11 | S1240 | ochoa | Dedicator of cytokinesis protein 11 (Activated Cdc42-associated guanine nucleotide exchange factor) (ACG) (Zizimin-2) | Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP (PubMed:37342957). Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology (By similarity). Facilitates filopodia formation through the activation of CDC42 (PubMed:37342957). {ECO:0000250|UniProtKB:A2AF47, ECO:0000269|PubMed:37342957}. |
| Q5M775 | SPECC1 | S917 | ochoa | Cytospin-B (Nuclear structure protein 5) (NSP5) (Sperm antigen HCMOGT-1) (Sperm antigen with calponin homology and coiled-coil domains 1) | None |
| Q5PRF9 | SAMD4B | S557 | ochoa | Protein Smaug homolog 2 (Smaug 2) (hSmaug2) (Sterile alpha motif domain-containing protein 4B) (SAM domain-containing protein 4B) | Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A. {ECO:0000269|PubMed:20510020}. |
| Q5SYE7 | NHSL1 | S328 | ochoa | NHS-like protein 1 | None |
| Q5VU92 | DCAF12L1 | S25 | ochoa | DDB1- and CUL4-associated factor 12-like protein 1 (WD repeat-containing protein 40B) | None |
| Q6P2E9 | EDC4 | S486 | ochoa | Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls) | In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). {ECO:0000269|PubMed:16364915}. |
| Q6PKG0 | LARP1 | S324 | ochoa | La-related protein 1 (La ribonucleoprotein domain family member 1) | RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:25940091, ECO:0000269|PubMed:26206669, ECO:0000269|PubMed:28379136, ECO:0000269|PubMed:28650797, ECO:0000269|PubMed:28673543, ECO:0000269|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| Q6S8J3 | POTEE | S935 | ochoa | POTE ankyrin domain family member E (ANKRD26-like family C member 1A) (Prostate, ovary, testis-expressed protein on chromosome 2) (POTE-2) | None |
| Q6UXY1 | BAIAP2L2 | S315 | ochoa | BAR/IMD domain-containing adapter protein 2-like 2 (Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2) (BAI1-associated protein 2-like protein 2) (Planar intestinal- and kidney-specific BAR domain protein) (Pinkbar) | Phosphoinositides-binding protein that induces the formation of planar or gently curved membrane structures. Binds to phosphoinositides, including to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) headgroups. There seems to be no clear preference for a specific phosphoinositide (By similarity). {ECO:0000250}. |
| Q6VEQ5 | WASH2P | S345 | ochoa | WAS protein family homolog 2 (CXYorf1-like protein on chromosome 2) (Protein FAM39B) | Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Involved in endocytic trafficking of EGF. Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration. In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T-cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation. Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling. Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex. Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity). {ECO:0000250|UniProtKB:A8K0Z3, ECO:0000250|UniProtKB:C4AMC7, ECO:0000250|UniProtKB:Q8VDD8}. |
| Q6VMQ6 | ATF7IP | S888 | ochoa | Activating transcription factor 7-interacting protein 1 (ATF-interacting protein) (ATF-IP) (ATF7-interacting protein) (ATFa-associated modulator) (hAM) (MBD1-containing chromatin-associated factor 1) (P621) | Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing (PubMed:27732843). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1 (PubMed:12665582). Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (PubMed:14536086, PubMed:27732843). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells (PubMed:19106100). {ECO:0000269|PubMed:12665582, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:19106100, ECO:0000269|PubMed:27732843}. |
| Q6ZWJ1 | STXBP4 | S463 | ochoa | Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (STX4-interacting protein) (Synip) | Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose (By similarity). {ECO:0000250}. |
| Q70CQ2 | USP34 | S490 | ochoa | Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.4.19.12) (Deubiquitinating enzyme 34) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) | Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. {ECO:0000269|PubMed:21383061}. |
| Q71RC2 | LARP4 | S673 | ochoa | La-related protein 4 (La ribonucleoprotein domain family member 4) | RNA binding protein that binds to the poly-A tract of mRNA molecules (PubMed:21098120). Associates with the 40S ribosomal subunit and with polysomes (PubMed:21098120). Plays a role in the regulation of mRNA translation (PubMed:21098120). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987, PubMed:27615744). {ECO:0000269|PubMed:21098120, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:27615744}. |
| Q71UI9 | H2AZ2 | S99 | ochoa | Histone H2A.V (H2A.F/Z) (H2A.Z variant histone 2) | Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division (By similarity). {ECO:0000250}. |
| Q7LDG7 | RASGRP2 | S578 | ochoa | RAS guanyl-releasing protein 2 (Calcium and DAG-regulated guanine nucleotide exchange factor I) (CalDAG-GEFI) (Cdc25-like protein) (hCDC25L) (F25B3.3 kinase-like protein) | Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activate other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway. {ECO:0000269|PubMed:10918068, ECO:0000269|PubMed:14702343, ECO:0000269|PubMed:17576779, ECO:0000269|PubMed:17702895, ECO:0000269|PubMed:24958846, ECO:0000269|PubMed:27235135}. |
| Q7Z3G6 | PRICKLE2 | S546 | ochoa | Prickle-like protein 2 | None |
| Q7Z3J3 | RGPD4 | S395 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z591 | AKNA | S537 | ochoa | Microtubule organization protein AKNA (AT-hook-containing transcription factor) | Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (By similarity). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (By similarity). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (By similarity). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (By similarity). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (PubMed:11268217). Binds to A/T-rich promoters (PubMed:11268217). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable). {ECO:0000250|UniProtKB:Q80VW7, ECO:0000269|PubMed:11268217, ECO:0000305}. |
| Q86TB9 | PATL1 | S120 | ochoa | Protein PAT1 homolog 1 (PAT1-like protein 1) (Protein PAT1 homolog b) (Pat1b) (hPat1b) | RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261). Acts as a scaffold protein that connects deadenylation and decapping machinery (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261). Required for cytoplasmic mRNA processing body (P-body) assembly (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261). {ECO:0000269|PubMed:17936923, ECO:0000269|PubMed:20543818, ECO:0000269|PubMed:20584987, ECO:0000269|PubMed:20852261}.; FUNCTION: (Microbial infection) In case of infection, required for translation and replication of hepatitis C virus (HCV). {ECO:0000269|PubMed:19628699}. |
| Q86UX7 | FERMT3 | S478 | ochoa | Fermitin family homolog 3 (Kindlin-3) (MIG2-like protein) (Unc-112-related protein 2) | Plays a central role in cell adhesion in hematopoietic cells (PubMed:19234463, PubMed:26359933). Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3) (By similarity). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells (PubMed:19234460). Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (By similarity). {ECO:0000250|UniProtKB:Q8K1B8, ECO:0000269|PubMed:19234460, ECO:0000269|PubMed:19234463, ECO:0000269|PubMed:26359933}.; FUNCTION: Isoform 2 may act as a repressor of NF-kappa-B and apoptosis. {ECO:0000269|PubMed:19064721, ECO:0000269|PubMed:19234460, ECO:0000269|PubMed:19234463}. |
| Q86WR7 | PROSER2 | S215 | ochoa | Proline and serine-rich protein 2 | None |
| Q86XZ4 | SPATS2 | S123 | ochoa | Spermatogenesis-associated serine-rich protein 2 (Serine-rich spermatocytes and round spermatid 59 kDa protein) (p59scr) | None |
| Q8IVT5 | KSR1 | S185 | ochoa | Kinase suppressor of Ras 1 (EC 2.7.11.1) | Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases (By similarity). Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 (PubMed:29433126). Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP (By similarity). Its kinase activity is unsure (By similarity). Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown (By similarity). {ECO:0000250|UniProtKB:Q61097, ECO:0000269|PubMed:29433126}. |
| Q8IWZ3 | ANKHD1 | S208 | ochoa | Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) | May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases. {ECO:0000269|PubMed:16098192}. |
| Q8NCN4 | RNF169 | S542 | ochoa | E3 ubiquitin-protein ligase RNF169 (EC 2.3.2.27) (RING finger protein 169) (RING-type E3 ubiquitin transferase RNF169) | Probable E3 ubiquitin-protein ligase that acts as a regulator of double-strand breaks (DSBs) repair following DNA damage. Functions in a non-canonical fashion to harness RNF168-mediated protein recruitment to DSB-containing chromatin, thereby contributing to regulation of DSB repair pathway utilization (PubMed:22492721, PubMed:30773093). Once recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168, competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby favouring homologous recombination repair (HRR) and single-strand annealing (SSA) instead of non-homologous end joining (NHEJ) mediated by TP53BP1 (PubMed:30104380, PubMed:30773093). E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair. {ECO:0000269|PubMed:22492721, ECO:0000269|PubMed:22733822, ECO:0000269|PubMed:22742833, ECO:0000269|PubMed:30104380, ECO:0000269|PubMed:30773093}. |
| Q8ND56 | LSM14A | S172 | ochoa | Protein LSM14 homolog A (Protein FAM61A) (Protein SCD6 homolog) (Putative alpha-synuclein-binding protein) (AlphaSNBP) (RNA-associated protein 55A) (hRAP55) (hRAP55A) | Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation (PubMed:16484376, PubMed:17074753, PubMed:29510985). Acts as a repressor of mRNA translation (PubMed:29510985). May play a role in mitotic spindle assembly (PubMed:26339800). {ECO:0000269|PubMed:16484376, ECO:0000269|PubMed:17074753, ECO:0000269|PubMed:26339800, ECO:0000269|PubMed:29510985}. |
| Q8NI77 | KIF18A | S841 | ochoa | Kinesin-like protein KIF18A (Marrow stromal KIF18A) (MS-KIF18A) | Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression. {ECO:0000269|PubMed:17346968, ECO:0000269|PubMed:18267093, ECO:0000269|PubMed:18513970, ECO:0000269|PubMed:19625775}. |
| Q8TDM6 | DLG5 | S1254 | ochoa | Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG) | Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). {ECO:0000250|UniProtKB:E9Q9R9, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:28169360}. |
| Q8TEU7 | RAPGEF6 | S1414 | ochoa | Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2) | Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP. {ECO:0000269|PubMed:11524421, ECO:0000269|PubMed:12581858}. |
| Q8TF01 | PNISR | S381 | ochoa | Arginine/serine-rich protein PNISR (PNN-interacting serine/arginine-rich protein) (SR-related protein) (SR-rich protein) (Serine/arginine-rich-splicing regulatory protein 130) (SRrp130) (Splicing factor, arginine/serine-rich 130) (Splicing factor, arginine/serine-rich 18) | None |
| Q8WUD1 | RAB2B | S70 | ochoa | Ras-related protein Rab-2B (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology. Regulates the compacted morphology of the Golgi (Probable). Promotes cytosolic DNA-induced innate immune responses. Regulates IFN responses against DNA viruses by regulating the CGAS-STING signaling axis (By similarity). Together with RAB2A redundantly required for efficient autophagic flux (PubMed:28483915). {ECO:0000250|UniProtKB:P59279, ECO:0000269|PubMed:28483915, ECO:0000305|PubMed:26209634}. |
| Q8WUF5 | PPP1R13L | S332 | ochoa | RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (NFkB-interacting protein 1) (PPP1R13B-like protein) | Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (PubMed:12524540). Is involved in NF-kappa-B dependent negative regulation of inflammatory response (PubMed:28069640). {ECO:0000269|PubMed:10336463, ECO:0000269|PubMed:12134007, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:15489900, ECO:0000269|PubMed:28069640}. |
| Q8WXE1 | ATRIP | S512 | ochoa | ATR-interacting protein (ATM and Rad3-related-interacting protein) | Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein. {ECO:0000269|PubMed:12791985}. |
| Q92994 | BRF1 | S435 | ochoa | Transcription factor IIIB 90 kDa subunit (TFIIIB90) (hTFIIIB90) (B-related factor 1) (BRF-1) (hBRF) (TAF3B2) (TATA box-binding protein-associated factor, RNA polymerase III, subunit 2) | General activator of RNA polymerase which utilizes different TFIIIB complexes at structurally distinct promoters. The isoform 1 is involved in the transcription of tRNA, adenovirus VA1, 7SL and 5S RNA. Isoform 2 is required for transcription of the U6 promoter. |
| Q96DF8 | ESS2 | S384 | ochoa | Splicing factor ESS-2 homolog (DiGeorge syndrome critical region 13) (DiGeorge syndrome critical region 14) (DiGeorge syndrome protein H) (DGS-H) (Protein ES2) | May be involved in pre-mRNA splicing. {ECO:0000250|UniProtKB:P34420}. |
| Q96JQ0 | DCHS1 | S2985 | ochoa | Protocadherin-16 (Cadherin-19) (Cadherin-25) (Fibroblast cadherin-1) (Protein dachsous homolog 1) | Calcium-dependent cell-adhesion protein. Mediates functions in neuroprogenitor cell proliferation and differentiation. In the heart, has a critical role for proper morphogenesis of the mitral valve, acting in the regulation of cell migration involved in valve formation (PubMed:26258302). {ECO:0000269|PubMed:26258302}. |
| Q96KS0 | EGLN2 | S74 | ochoa | Prolyl hydroxylase EGLN2 (EC 1.14.11.-) (Egl nine homolog 2) (EC 1.14.11.29) (Estrogen-induced tag 6) (EIT-6) (HPH-3) (Hypoxia-inducible factor prolyl hydroxylase 1) (HIF-PH1) (HIF-prolyl hydroxylase 1) (HPH-1) (Prolyl hydroxylase domain-containing protein 1) (PHD1) | Prolyl hydroxylase that mediates hydroxylation of proline residues in target proteins, such as ATF4, IKBKB, CEP192 and HIF1A (PubMed:11595184, PubMed:12039559, PubMed:15925519, PubMed:16509823, PubMed:17114296, PubMed:23932902). Target proteins are preferentially recognized via a LXXLAP motif (PubMed:11595184, PubMed:12039559, PubMed:15925519). Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins (PubMed:11595184, PubMed:12039559, PubMed:12181324, PubMed:15925519, PubMed:19339211). Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A (PubMed:11595184, PubMed:12039559, PubMed:12181324, PubMed:15925519). Also hydroxylates HIF2A (PubMed:11595184, PubMed:12039559, PubMed:15925519). Has a preference for the CODD site for both HIF1A and HIF2A (PubMed:11595184, PubMed:12039559, PubMed:15925519). Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex (PubMed:11595184, PubMed:12039559, PubMed:15925519). Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes (PubMed:11595184, PubMed:12039559, PubMed:15925519). EGLN2 is involved in regulating hypoxia tolerance and apoptosis in cardiac and skeletal muscle (PubMed:11595184, PubMed:12039559, PubMed:15925519). Also regulates susceptibility to normoxic oxidative neuronal death (PubMed:11595184, PubMed:12039559, PubMed:15925519). Links oxygen sensing to cell cycle and primary cilia formation by hydroxylating the critical centrosome component CEP192 which promotes its ubiquitination and subsequent proteasomal degradation (PubMed:23932902). Hydroxylates IKBKB, mediating NF-kappa-B activation in hypoxic conditions (PubMed:17114296). Also mediates hydroxylation of ATF4, leading to decreased protein stability of ATF4 (By similarity). {ECO:0000250|UniProtKB:Q91YE2, ECO:0000269|PubMed:11595184, ECO:0000269|PubMed:12039559, ECO:0000269|PubMed:12181324, ECO:0000269|PubMed:15925519, ECO:0000269|PubMed:16509823, ECO:0000269|PubMed:17114296, ECO:0000269|PubMed:19339211, ECO:0000269|PubMed:23932902}. |
| Q96MG7 | NSMCE3 | S51 | ochoa | Non-structural maintenance of chromosomes element 3 homolog (Non-SMC element 3 homolog) (Hepatocellular carcinoma-associated protein 4) (MAGE-G1 antigen) (Melanoma-associated antigen G1) (Necdin-like protein 2) | Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination (PubMed:20864041, PubMed:27427983). The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). In vitro enhances ubiquitin ligase activity of NSMCE1. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (PubMed:20864041). May be a growth suppressor that facilitates the entry of the cell into cell cycle arrest (By similarity). {ECO:0000250|UniProtKB:Q9CPR8, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:27427983}. |
| Q96QE2 | SLC2A13 | S50 | ochoa | Proton myo-inositol cotransporter (H(+)-myo-inositol cotransporter) (Hmit) (H(+)-myo-inositol symporter) (Solute carrier family 2 member 13) | H(+)-myo-inositol cotransporter (PubMed:11500374). Can also transport related stereoisomers (PubMed:11500374). {ECO:0000269|PubMed:11500374}. |
| Q96RF0 | SNX18 | S199 | ochoa | Sorting nexin-18 (SH3 and PX domain-containing protein 3B) | Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis (PubMed:18411244, PubMed:20427313, PubMed:21048941, PubMed:22718350). Required for efficient progress through mitosis and cytokinesis (PubMed:22718350). Required for normal formation of the cleavage furrow at the end of mitosis (PubMed:22718350). Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis (PubMed:20427313). Plays a role in macropinocytosis (PubMed:21048941). Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation (PubMed:18411244). Stimulates the GTPase activity of DNM2 (PubMed:20427313). Promotes DNM2 location at the plasma membrane (PubMed:20427313). Together with DNM2, involved in autophagosome assembly by regulating trafficking from recycling endosomes of phospholipid scramblase ATG9A (PubMed:29437695). {ECO:0000269|PubMed:18411244, ECO:0000269|PubMed:20427313, ECO:0000269|PubMed:21048941, ECO:0000269|PubMed:22718350, ECO:0000269|PubMed:29437695}. |
| Q96RG2 | PASK | S109 | ochoa | PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (hPASK) (EC 2.7.11.1) | Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation. {ECO:0000269|PubMed:16275910, ECO:0000269|PubMed:17052199, ECO:0000269|PubMed:17595531, ECO:0000269|PubMed:20943661, ECO:0000269|PubMed:21181396, ECO:0000269|PubMed:21418524}. |
| Q96RY5 | CRAMP1 | S27 | ochoa | Protein cramped-like (Cramped chromatin regulator homolog 1) (Hematological and neurological expressed 1-like protein) | None |
| Q96S82 | UBL7 | S255 | ochoa | Ubiquitin-like protein 7 (Bone marrow stromal cell ubiquitin-like protein) (BMSC-UbP) (Ubiquitin-like protein SB132) | Interferon-stimulated protein that positively regulates RNA virus-triggered innate immune signaling. Mechanistically, promotes 'Lys-27'-linked polyubiquitination of MAVS through TRIM21 leading to enhanced the IFN signaling pathway. {ECO:0000269|PubMed:19690332}. |
| Q9BR76 | CORO1B | S443 | ochoa | Coronin-1B (Coronin-2) | Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity). {ECO:0000250, ECO:0000269|PubMed:16027158}. |
| Q9BRK4 | LZTS2 | S279 | ochoa | Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1) | Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. {ECO:0000255|HAMAP-Rule:MF_03026, ECO:0000269|PubMed:17000760, ECO:0000269|PubMed:17351128, ECO:0000269|PubMed:17950943, ECO:0000269|PubMed:18490357}. |
| Q9BTL4 | IER2 | S126 | ochoa | Immediate early response gene 2 protein (Protein ETR101) | DNA-binding protein that seems to act as a transcription factor (PubMed:19584537). Involved in the regulation of neuronal differentiation, acts upon JNK-signaling pathway activation and plays a role in neurite outgrowth in hippocampal cells (By similarity). May mediate with FIBP FGF-signaling in the establishment of laterality in the embryo (By similarity). Promotes cell motility, seems to stimulate tumor metastasis (PubMed:22120713). {ECO:0000250|UniProtKB:B7SXM5, ECO:0000250|UniProtKB:Q6P7D3, ECO:0000269|PubMed:19584537, ECO:0000269|PubMed:22120713}. |
| Q9BVT8 | TMUB1 | S127 | ochoa | Transmembrane and ubiquitin-like domain-containing protein 1 (Dendritic cell-derived ubiquitin-like protein) (DULP) (Hepatocyte odd protein shuttling protein) (Ubiquitin-like protein SB144) [Cleaved into: iHOPS] | Involved in sterol-regulated ubiquitination and degradation of HMG-CoA reductase HMGCR (PubMed:21343306). Involved in positive regulation of AMPA-selective glutamate receptor GRIA2 recycling to the cell surface (By similarity). Acts as a negative regulator of hepatocyte growth during regeneration (By similarity). {ECO:0000250|UniProtKB:Q53AQ4, ECO:0000250|UniProtKB:Q9JMG3, ECO:0000269|PubMed:21343306}.; FUNCTION: [iHOPS]: May contribute to the regulation of translation during cell-cycle progression. May contribute to the regulation of cell proliferation (By similarity). May be involved in centrosome assembly. Modulates stabilization and nucleolar localization of tumor suppressor CDKN2A and enhances association between CDKN2A and NPM1 (By similarity). {ECO:0000250|UniProtKB:Q9JMG3}. |
| Q9BXI3 | NT5C1A | S204 | ochoa | Cytosolic 5'-nucleotidase 1A (cN1A) (EC 3.1.3.5) (EC 3.1.3.89) (EC 3.1.3.99) (5'-deoxynucleotidase) (Cytosolic 5'-nucleotidase IA) (cN-I) (cN-IA) | Catalyzes the hydrolysis of ribonucleotide and deoxyribonucleotide monophosphates, releasing inorganic phosphate and the corresponding nucleoside (PubMed:11133996, PubMed:34814800, PubMed:7599155, PubMed:8967393). AMP is the major substrate but can also hydrolyze dCMP and IMP (PubMed:11133996, PubMed:34814800, PubMed:7599155, PubMed:8967393). {ECO:0000269|PubMed:11133996, ECO:0000269|PubMed:34814800, ECO:0000269|PubMed:7599155, ECO:0000269|PubMed:8967393}. |
| Q9BZZ5 | API5 | S485 | ochoa | Apoptosis inhibitor 5 (API-5) (Antiapoptosis clone 11 protein) (AAC-11) (Cell migration-inducing gene 8 protein) (Fibroblast growth factor 2-interacting factor) (FIF) (Protein XAGL) | Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. {ECO:0000269|PubMed:10780674, ECO:0000269|PubMed:17112319, ECO:0000269|PubMed:19387494}. |
| Q9C0C2 | TNKS1BP1 | S714 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9H0B6 | KLC2 | S539 | ochoa | Kinesin light chain 2 (KLC 2) | Kinesin is a microtubule-associated force-producing protein that plays a role in organelle transport. The light chain functions in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (Probable). Through binding with PLEKHM2 and ARL8B, recruits kinesin-1 to lysosomes and hence direct lysosomes movement toward microtubule plus ends (PubMed:22172677). {ECO:0000269|PubMed:22172677, ECO:0000305|PubMed:22172677}. |
| Q9H1B7 | IRF2BPL | S553 | ochoa | Probable E3 ubiquitin-protein ligase IRF2BPL (EC 2.3.2.27) (Enhanced at puberty protein 1) (Interferon regulatory factor 2-binding protein-like) | Probable E3 ubiquitin protein ligase involved in the proteasome-mediated ubiquitin-dependent degradation of target proteins (PubMed:29374064). Through the degradation of CTNNB1, functions downstream of FOXF2 to negatively regulate the Wnt signaling pathway (PubMed:29374064). Probably plays a role in the development of the central nervous system and in neuronal maintenance (Probable). Also acts as a transcriptional regulator of genes controlling female reproductive function. May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter (By similarity). {ECO:0000250|UniProtKB:Q5EIC4, ECO:0000269|PubMed:29374064, ECO:0000305|PubMed:17334524, ECO:0000305|PubMed:29374064, ECO:0000305|PubMed:30057031}. |
| Q9H7P9 | PLEKHG2 | S54 | ochoa | Pleckstrin homology domain-containing family G member 2 (PH domain-containing family G member 2) | May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein) (PubMed:18045877). Involved in the regulation of actin polymerization (PubMed:26573021). {ECO:0000250|UniProtKB:Q6KAU7, ECO:0000269|PubMed:18045877, ECO:0000269|PubMed:26573021}. |
| Q9H7P9 | PLEKHG2 | S1289 | ochoa | Pleckstrin homology domain-containing family G member 2 (PH domain-containing family G member 2) | May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein) (PubMed:18045877). Involved in the regulation of actin polymerization (PubMed:26573021). {ECO:0000250|UniProtKB:Q6KAU7, ECO:0000269|PubMed:18045877, ECO:0000269|PubMed:26573021}. |
| Q9HB19 | PLEKHA2 | S314 | ochoa | Pleckstrin homology domain-containing family A member 2 (PH domain-containing family A member 2) (Tandem PH domain-containing protein 2) (TAPP-2) | Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity). {ECO:0000250}. |
| Q9HCU4 | CELSR2 | S2665 | ochoa | Cadherin EGF LAG seven-pass G-type receptor 2 (Cadherin family member 10) (Epidermal growth factor-like protein 2) (EGF-like protein 2) (Flamingo homolog 3) (Multiple epidermal growth factor-like domains protein 3) (Multiple EGF-like domains protein 3) | Receptor that may have an important role in cell/cell signaling during nervous system formation. |
| Q9HD26 | GOPC | S276 | ochoa | Golgi-associated PDZ and coiled-coil motif-containing protein (CFTR-associated ligand) (Fused in glioblastoma) (PDZ protein interacting specifically with TC10) (PIST) | Plays a role in intracellular protein trafficking and degradation (PubMed:11707463, PubMed:14570915, PubMed:15358775). May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels (By similarity). May also regulate the intracellular trafficking of the ADR1B receptor (PubMed:15358775). May play a role in autophagy (By similarity). Together with MARCHF2 mediates the ubiquitination and lysosomal degradation of CFTR (PubMed:23818989). Overexpression results in CFTR intracellular retention and lysosomaldegradation in the lysosomes (PubMed:11707463, PubMed:14570915). {ECO:0000250|UniProtKB:Q8BH60, ECO:0000269|PubMed:11707463, ECO:0000269|PubMed:14570915, ECO:0000269|PubMed:15358775, ECO:0000269|PubMed:23818989}. |
| Q9NQA3 | WASH6P | S327 | ochoa | WAS protein family homolog 6 (Protein FAM39A) | May act as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. {ECO:0000250|UniProtKB:A8K0Z3, ECO:0000250|UniProtKB:C4AMC7}. |
| Q9NS62 | THSD1 | S479 | ochoa | Thrombospondin type-1 domain-containing protein 1 (Transmembrane molecule with thrombospondin module) | Is a positive regulator of nascent focal adhesion assembly, involved in the modulation of endothelial cell attachment to the extracellular matrix. {ECO:0000269|PubMed:27895300, ECO:0000269|PubMed:29069646}. |
| Q9NX63 | CHCHD3 | S46 | ochoa | MICOS complex subunit MIC19 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 3) | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (PubMed:25781180, PubMed:32567732, PubMed:33130824). Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:25781180, PubMed:32567732, PubMed:33130824). Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription (PubMed:22567091). {ECO:0000269|PubMed:22567091, ECO:0000269|PubMed:25781180, ECO:0000269|PubMed:32567732, ECO:0000269|PubMed:33130824}. |
| Q9P219 | CCDC88C | S1740 | ochoa | Protein Daple (Coiled-coil domain-containing protein 88C) (Dvl-associating protein with a high frequency of leucine residues) (hDaple) (Hook-related protein 2) (HkRP2) | Required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling (PubMed:26126266). Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signaling (PubMed:26126266). Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation (PubMed:26126266). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex, triggering non-canonical Wnt responses such as activation of RAC1 and PI3K-AKT signaling (PubMed:26126266). Promotes apical constriction of cells via ARHGEF18 (PubMed:30948426). {ECO:0000269|PubMed:26126266, ECO:0000269|PubMed:30948426}. |
| Q9P2F8 | SIPA1L2 | S197 | ochoa | Signal-induced proliferation-associated 1-like protein 2 (SIPA1-like protein 2) | None |
| Q9UBC2 | EPS15L1 | S587 | ochoa | Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) | Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:9407958}. |
| Q9UIF9 | BAZ2A | S1750 | ochoa | Bromodomain adjacent to zinc finger domain protein 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3) | Regulatory subunit of the ATP-dependent NoRC-1 and NoRC-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Directly stimulates the ATPase activity of SMARCA5 in the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). The NoRC-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NoRC-5 ISWI chromatin remodeling complex, mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription (By similarity). Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac (By similarity). Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity). {ECO:0000250|UniProtKB:Q91YE5, ECO:0000269|PubMed:28801535}. |
| Q9UKD1 | GMEB2 | S379 | ochoa | Glucocorticoid modulatory element-binding protein 2 (GMEB-2) (DNA-binding protein p79PIF) (Parvovirus initiation factor p79) (PIF p79) | Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Also binds to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses. |
| Q9UMZ2 | SYNRG | S812 | ochoa | Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin) | Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN) (PubMed:15758025). May act by linking the adapter protein complex AP-1 to other proteins (Probable). Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025, ECO:0000305|PubMed:12538641}. |
| Q9UPU9 | SAMD4A | S580 | ochoa | Protein Smaug homolog 1 (Smaug 1) (hSmaug1) (Sterile alpha motif domain-containing protein 4A) (SAM domain-containing protein 4A) | Acts as a translational repressor of SRE-containing messengers. {ECO:0000269|PubMed:16221671}. |
| Q9Y446 | PKP3 | S95 | ochoa | Plakophilin-3 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:24124604). Required for the localization of DSG2, DSP and PKP2 to mature desmosome junctions (PubMed:20859650). May also play a role in the maintenance of DSG3 protein abundance in keratinocytes (By similarity). Required for the formation of DSP-containing desmosome precursors in the cytoplasm during desmosome assembly (PubMed:25208567). Also regulates the accumulation of CDH1 to mature desmosome junctions, via cAMP-dependent signaling and its interaction with activated RAP1A (PubMed:25208567). Positively regulates the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with FXR1, may also regulate the protein abundance of DSP via the same mechanism (PubMed:25225333). May also regulate the protein abundance of the desmosome component PKP1 (By similarity). Required for the organization of desmosome junctions at intercellular borders between basal keratinocytes of the epidermis, as a result plays a role in maintenance of the dermal barrier and regulation of the dermal inflammatory response (By similarity). Required during epidermal keratinocyte differentiation for cell adherence at tricellular cell-cell contacts, via regulation of the timely formation of adherens junctions and desmosomes in a calcium-dependent manner, and may also play a role in the organization of the intracellular actin fiber belt (By similarity). Acts as a negative regulator of the inflammatory response in hematopoietic cells of the skin and intestine, via modulation of proinflammatory cytokine production (By similarity). Important for epithelial barrier maintenance in the intestine to reduce intestinal permeability, thereby plays a role in protection from intestinal-derived endotoxemia (By similarity). Required for the development of hair follicles, via a role in the regulation of inner root sheaf length, correct alignment and anterior-posterior polarity of hair follicles (By similarity). Promotes proliferation and cell-cycle G1/S phase transition of keratinocytes (By similarity). Promotes E2F1-driven transcription of G1/S phase promoting genes by acting to release E2F1 from its inhibitory interaction with RB1, via sequestering RB1 and CDKN1A to the cytoplasm and thereby increasing CDK4- and CDK6-driven phosphorylation of RB1 (By similarity). May act as a scaffold protein to facilitate MAPK phosphorylation of RPS6KA protein family members and subsequently promote downstream EGFR signaling (By similarity). May play a role in the positive regulation of transcription of Wnt-mediated TCF-responsive target genes (PubMed:34058472). {ECO:0000250|UniProtKB:Q9QY23, ECO:0000269|PubMed:20859650, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:34058472}. |
| Q9Y4B4 | RAD54L2 | S1234 | ochoa | Helicase ARIP4 (EC 3.6.4.12) (Androgen receptor-interacting protein 4) (RAD54-like protein 2) | DNA helicase that modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. Not able to remodel mononucleosomes in vitro (By similarity). {ECO:0000250}. |
| Q9Y4F1 | FARP1 | S899 | ochoa | FERM, ARHGEF and pleckstrin domain-containing protein 1 (Chondrocyte-derived ezrin-like protein) (FERM, RhoGEF and pleckstrin domain-containing protein 1) (Pleckstrin homology domain-containing family C member 2) (PH domain-containing family C member 2) | Functions as a guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). {ECO:0000250}. |
| Q9Y561 | LRP12 | S617 | ochoa | Low-density lipoprotein receptor-related protein 12 (LDLR-related protein 12) (LRP-12) (Suppressor of tumorigenicity 7 protein) | Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor. {ECO:0000269|PubMed:12809483}. |
| Q9Y613 | FHOD1 | S1137 | psp | FH1/FH2 domain-containing protein 1 (Formin homolog overexpressed in spleen 1) (FHOS) (Formin homology 2 domain-containing protein 1) | Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing. {ECO:0000269|PubMed:14576350, ECO:0000269|PubMed:15878344, ECO:0000269|PubMed:18694941}. |
| Q9Y617 | PSAT1 | S331 | ochoa | Phosphoserine aminotransferase (EC 2.6.1.52) (Phosphohydroxythreonine aminotransferase) (PSAT) | Involved in L-serine biosynthesis via the phosphorylated pathway, a three-step pathway converting the glycolytic intermediate 3-phospho-D-glycerate into L-serine. Catalyzes the second step, that is the pyridoxal 5'-phosphate-dependent transamination of 3-phosphohydroxypyruvate and L-glutamate to O-phosphoserine (OPS) and alpha-ketoglutarate. {ECO:0000269|PubMed:36851825, ECO:0000269|PubMed:37627284}. |
| P40227 | CCT6A | S301 | Sugiyama | T-complex protein 1 subunit zeta (TCP-1-zeta) (EC 3.6.1.-) (Acute morphine dependence-related protein 2) (CCT-zeta-1) (Chaperonin containing T-complex polypeptide 1 subunit 6A) (HTR3) (Tcp20) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). {ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P07203 | GPX1 | S95 | Sugiyama | Glutathione peroxidase 1 (GPx-1) (GSHPx-1) (EC 1.11.1.9) (Cellular glutathione peroxidase) (Phospholipid-hydroperoxide glutathione peroxidase GPX1) (EC 1.11.1.12) | Catalyzes the reduction of hydroperoxides in a glutathione-dependent manner thus regulating cellular redox homeostasis (PubMed:11115402, PubMed:36608588). Can reduce small soluble hydroperoxides such as H2O2, cumene hydroperoxide and tert-butyl hydroperoxide, as well as several fatty acid-derived hydroperoxides (PubMed:11115402, PubMed:36608588). In platelets catalyzes the reduction of 12-hydroperoxyeicosatetraenoic acid, the primary product of the arachidonate 12-lipoxygenase pathway (PubMed:11115402). {ECO:0000269|PubMed:11115402, ECO:0000269|PubMed:36608588}. |
| Q5BKZ1 | ZNF326 | S121 | Sugiyama | DBIRD complex subunit ZNF326 (Zinc finger protein 326) (Zinc finger protein interacting with mRNPs and DBC1) | Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. May play a role in neuronal differentiation and is able to bind DNA and activate expression in vitro. {ECO:0000269|PubMed:22446626}. |
| Q8NBP7 | PCSK9 | S488 | Sugiyama | Proprotein convertase subtilisin/kexin type 9 (EC 3.4.21.-) (Neural apoptosis-regulated convertase 1) (NARC-1) (Proprotein convertase 9) (PC9) (Subtilisin/kexin-like protease PC9) | Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments (PubMed:18039658). Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation (PubMed:17461796, PubMed:18197702, PubMed:18799458, PubMed:22074827). Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner. Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway (PubMed:18660751). Inhibits epithelial Na(+) channel (ENaC)-mediated Na(+) absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation. Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways. {ECO:0000269|PubMed:17461796, ECO:0000269|PubMed:18039658, ECO:0000269|PubMed:18197702, ECO:0000269|PubMed:18660751, ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22074827, ECO:0000269|PubMed:22493497, ECO:0000269|PubMed:22580899}. |
| O15417 | TNRC18 | S660 | PSP | Trinucleotide repeat-containing gene 18 protein (Long CAG trinucleotide repeat-containing gene 79 protein) | None |
| Q9H0C2 | SLC25A31 | S286 | Sugiyama | ADP/ATP translocase 4 (ADP,ATP carrier protein 4) (Adenine nucleotide translocator 4) (ANT 4) (Solute carrier family 25 member 31) (Sperm flagellar energy carrier protein) | ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity) (PubMed:15670820). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity). Specifically required during spermatogenesis, probably to mediate ADP:ATP exchange in spermatocytes (PubMed:17137571). Large ATP supplies from mitochondria may be critical for normal progression of spermatogenesis during early stages of meiotic prophase I, including DNA double-strand break repair and chromosomal synapsis (By similarity). In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity (By similarity). Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis (By similarity). Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A31/ANT4 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity) (By similarity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it (By similarity). Among nucleotides, may also exchange ADP for dATP and dADP (PubMed:15670820). Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death (By similarity). It is however unclear if SLC25A31/ANT4 constitutes a pore-forming component of mPTP or regulates it (By similarity). {ECO:0000250|UniProtKB:G2QNH0, ECO:0000250|UniProtKB:P48962, ECO:0000250|UniProtKB:Q3V132, ECO:0000269|PubMed:15670820, ECO:0000269|PubMed:17137571}. |
| O15230 | LAMA5 | S1616 | Sugiyama | Laminin subunit alpha-5 (Laminin-10 subunit alpha) (Laminin-11 subunit alpha) (Laminin-15 subunit alpha) | Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Plays a role in the regulation of skeletogenesis, through a mechanism that involves integrin-mediated signaling and PTK2B/PYK2 (PubMed:33242826). {ECO:0000269|PubMed:33242826}. |
| Q14571 | ITPR2 | S150 | SIGNOR | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2 (IP3 receptor isoform 2) (IP3R 2) (InsP3R2) (Inositol 1,4,5-trisphosphate receptor type 2) (Type 2 inositol 1,4,5-trisphosphate receptor) (Type 2 InsP3 receptor) | Inositol 1,4,5-trisphosphate-gated calcium channel that upon inositol 1,4,5-trisphosphate binding transports calcium from the endoplasmic reticulum lumen to cytoplasm. Exists in two states; a long-lived closed state where the channel is essentially 'parked' with only very rare visits to an open state and that ligands facilitate the transition from the 'parked' state into a 'drive' mode represented by periods of bursting activity (By similarity). {ECO:0000250|UniProtKB:Q9Z329}. |
| O14519 | CDK2AP1 | S46 | SIGNOR|EPSD|PSP | Cyclin-dependent kinase 2-associated protein 1 (CDK2-associated protein 1) (Deleted in oral cancer 1) (DOC-1) (Putative oral cancer suppressor) | Inhibitor of cyclin-dependent kinase CDK2 (By similarity). Also acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:20523938, PubMed:28977666). {ECO:0000250|UniProtKB:O35207, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:20523938, ECO:0000269|PubMed:28977666}. |
| O15067 | PFAS | S513 | Sugiyama | Phosphoribosylformylglycinamidine synthase (FGAM synthase) (FGAMS) (EC 6.3.5.3) (Formylglycinamide ribonucleotide amidotransferase) (FGAR amidotransferase) (FGAR-AT) (Formylglycinamide ribotide amidotransferase) (Phosphoribosylformylglycineamide amidotransferase) | Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. {ECO:0000305|PubMed:10548741}. |
| Q96KB5 | PBK | S110 | Sugiyama | Lymphokine-activated killer T-cell-originated protein kinase (EC 2.7.12.2) (Cancer/testis antigen 84) (CT84) (MAPKK-like protein kinase) (Nori-3) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (T-LAK cell-originated protein kinase) | Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. {ECO:0000269|PubMed:10781613, ECO:0000269|PubMed:17482142}. |
| Q9BZC7 | ABCA2 | S1371 | Sugiyama | ATP-binding cassette sub-family A member 2 (EC 7.6.2.-) (ATP-binding cassette transporter 2) (ATP-binding cassette 2) | Probable lipid transporter that modulates cholesterol sequestration in the late endosome/lysosome by regulating the intracellular sphingolipid metabolism, in turn participates in cholesterol homeostasis (Probable) (PubMed:15238223, PubMed:21810484, PubMed:24201375). May alter the transbilayer distribution of ceramide in the intraluminal membrane lipid bilayer, favoring its retention in the outer leaflet that results in increased acid ceramidase activity in the late endosome/lysosome, facilitating ceramide deacylation to sphingosine leading to the sequestration of free cholesterol in lysosomes (PubMed:24201375). In addition regulates amyloid-beta production either by activating a signaling pathway that regulates amyloid precursor protein transcription through the modulation of sphingolipid metabolism or through its role in gamma-secretase processing of APP (PubMed:22086926, PubMed:26510981). May play a role in myelin formation (By similarity). {ECO:0000250|UniProtKB:P41234, ECO:0000269|PubMed:15238223, ECO:0000269|PubMed:21810484, ECO:0000269|PubMed:22086926, ECO:0000269|PubMed:24201375, ECO:0000269|PubMed:26510981, ECO:0000305|PubMed:15999530}. |
| Q9UPN9 | TRIM33 | S949 | Sugiyama | E3 ubiquitin-protein ligase TRIM33 (EC 2.3.2.27) (Ectodermin homolog) (RET-fused gene 7 protein) (Protein Rfg7) (RING-type E3 ubiquitin transferase TRIM33) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) | Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade). {ECO:0000250, ECO:0000269|PubMed:10022127, ECO:0000269|PubMed:15820681, ECO:0000269|PubMed:16751102, ECO:0000269|PubMed:19135894}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 2.779044e-07 | 6.556 |
| R-HSA-9764561 | Regulation of CDH1 Function | 9.656569e-07 | 6.015 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 1.281656e-05 | 4.892 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 1.431644e-05 | 4.844 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 1.431644e-05 | 4.844 |
| R-HSA-5674135 | MAP2K and MAPK activation | 2.333625e-05 | 4.632 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 2.333625e-05 | 4.632 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 3.990548e-05 | 4.399 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 3.990548e-05 | 4.399 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 3.990548e-05 | 4.399 |
| R-HSA-6802949 | Signaling by RAS mutants | 3.990548e-05 | 4.399 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 3.977014e-05 | 4.400 |
| R-HSA-9652169 | Signaling by MAP2K mutants | 4.863104e-05 | 4.313 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 5.143510e-05 | 4.289 |
| R-HSA-421270 | Cell-cell junction organization | 7.027183e-05 | 4.153 |
| R-HSA-418990 | Adherens junctions interactions | 9.735925e-05 | 4.012 |
| R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 1.133742e-04 | 3.945 |
| R-HSA-446728 | Cell junction organization | 1.690200e-04 | 3.772 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 2.042016e-04 | 3.690 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 4.667327e-04 | 3.331 |
| R-HSA-1500931 | Cell-Cell communication | 4.936450e-04 | 3.307 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 7.256294e-04 | 3.139 |
| R-HSA-170968 | Frs2-mediated activation | 1.009750e-03 | 2.996 |
| R-HSA-169893 | Prolonged ERK activation events | 1.603980e-03 | 2.795 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 2.466936e-03 | 2.608 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 2.425797e-03 | 2.615 |
| R-HSA-445144 | Signal transduction by L1 | 3.006334e-03 | 2.522 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 3.830782e-03 | 2.417 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 3.830782e-03 | 2.417 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 3.960219e-03 | 2.402 |
| R-HSA-373760 | L1CAM interactions | 3.852113e-03 | 2.414 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 4.120779e-03 | 2.385 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 4.540801e-03 | 2.343 |
| R-HSA-525793 | Myogenesis | 5.952507e-03 | 2.225 |
| R-HSA-8949275 | RUNX3 Regulates Immune Response and Cell Migration | 5.897754e-03 | 2.229 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 6.303647e-03 | 2.200 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 6.474897e-03 | 2.189 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 6.941651e-03 | 2.159 |
| R-HSA-196025 | Formation of annular gap junctions | 7.083796e-03 | 2.150 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 7.377494e-03 | 2.132 |
| R-HSA-190873 | Gap junction degradation | 8.368354e-03 | 2.077 |
| R-HSA-112411 | MAPK1 (ERK2) activation | 8.368354e-03 | 2.077 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 8.832433e-03 | 2.054 |
| R-HSA-162582 | Signal Transduction | 8.577204e-03 | 2.067 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 8.042410e-03 | 2.095 |
| R-HSA-9762292 | Regulation of CDH11 function | 9.749090e-03 | 2.011 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 1.017590e-02 | 1.992 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 1.163169e-02 | 1.934 |
| R-HSA-5673000 | RAF activation | 1.163169e-02 | 1.934 |
| R-HSA-187687 | Signalling to ERKs | 1.240218e-02 | 1.907 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 1.184252e-02 | 1.927 |
| R-HSA-9700206 | Signaling by ALK in cancer | 1.184252e-02 | 1.927 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 1.278994e-02 | 1.893 |
| R-HSA-8941326 | RUNX2 regulates bone development | 1.320130e-02 | 1.879 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 1.454615e-02 | 1.837 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 1.402918e-02 | 1.853 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 1.618840e-02 | 1.791 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 1.622129e-02 | 1.790 |
| R-HSA-68875 | Mitotic Prophase | 1.876798e-02 | 1.727 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 1.992715e-02 | 1.701 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 1.992715e-02 | 1.701 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 1.949628e-02 | 1.710 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 1.992715e-02 | 1.701 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 2.170009e-02 | 1.664 |
| R-HSA-194138 | Signaling by VEGF | 2.215541e-02 | 1.655 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 2.398946e-02 | 1.620 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 2.423828e-02 | 1.615 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 2.506051e-02 | 1.601 |
| R-HSA-437239 | Recycling pathway of L1 | 2.506051e-02 | 1.601 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 2.324645e-02 | 1.634 |
| R-HSA-5210891 | Uptake and function of anthrax toxins | 2.613687e-02 | 1.583 |
| R-HSA-5684045 | Defective ABCD1 causes ALD | 4.420764e-02 | 1.355 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 5.495240e-02 | 1.260 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 5.495240e-02 | 1.260 |
| R-HSA-9706377 | FLT3 signaling by CBL mutants | 7.608287e-02 | 1.119 |
| R-HSA-9652817 | Signaling by MAPK mutants | 8.647122e-02 | 1.063 |
| R-HSA-5619070 | Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) | 9.674341e-02 | 1.014 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 1.069007e-01 | 0.971 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 1.069007e-01 | 0.971 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 1.069007e-01 | 0.971 |
| R-HSA-110056 | MAPK3 (ERK1) activation | 1.366961e-01 | 0.864 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 1.464065e-01 | 0.834 |
| R-HSA-429947 | Deadenylation of mRNA | 4.585315e-02 | 1.339 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 4.585315e-02 | 1.339 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 1.560083e-01 | 0.807 |
| R-HSA-202670 | ERKs are inactivated | 1.560083e-01 | 0.807 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 1.560083e-01 | 0.807 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 1.655027e-01 | 0.781 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 1.655027e-01 | 0.781 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 1.655027e-01 | 0.781 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 1.655027e-01 | 0.781 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 1.655027e-01 | 0.781 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 1.655027e-01 | 0.781 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 1.748909e-01 | 0.757 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 6.019489e-02 | 1.220 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 6.019489e-02 | 1.220 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 1.933532e-01 | 0.714 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 1.933532e-01 | 0.714 |
| R-HSA-8964315 | G beta:gamma signalling through BTK | 1.933532e-01 | 0.714 |
| R-HSA-390522 | Striated Muscle Contraction | 7.584312e-02 | 1.120 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 7.584312e-02 | 1.120 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 3.257224e-02 | 1.487 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 3.962881e-02 | 1.402 |
| R-HSA-418217 | G beta:gamma signalling through PLC beta | 2.290543e-01 | 0.640 |
| R-HSA-912631 | Regulation of signaling by CBL | 2.377313e-01 | 0.624 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 2.377313e-01 | 0.624 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 2.463111e-01 | 0.609 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 2.463111e-01 | 0.609 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 2.463111e-01 | 0.609 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.463111e-01 | 0.609 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.463111e-01 | 0.609 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 5.762151e-02 | 1.239 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 5.941968e-02 | 1.226 |
| R-HSA-72649 | Translation initiation complex formation | 1.558604e-01 | 0.807 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 1.637645e-01 | 0.786 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 1.797755e-01 | 0.745 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 2.872525e-01 | 0.542 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 2.872525e-01 | 0.542 |
| R-HSA-182971 | EGFR downregulation | 6.630815e-02 | 1.178 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 2.116090e-01 | 0.674 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 2.116090e-01 | 0.674 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 4.026231e-02 | 1.395 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 2.116090e-01 | 0.674 |
| R-HSA-1234174 | Cellular response to hypoxia | 2.000995e-01 | 0.699 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 8.087887e-02 | 1.092 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 7.911296e-02 | 1.102 |
| R-HSA-8964616 | G beta:gamma signalling through CDC42 | 2.114047e-01 | 0.675 |
| R-HSA-202040 | G-protein activation | 2.547949e-01 | 0.594 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 1.441514e-01 | 0.841 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 1.717385e-01 | 0.765 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 7.608287e-02 | 1.119 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 8.917739e-02 | 1.050 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 3.795879e-02 | 1.421 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 4.112579e-02 | 1.386 |
| R-HSA-5635851 | GLI proteins bind promoters of Hh responsive genes to promote transcription | 8.647122e-02 | 1.063 |
| R-HSA-433692 | Proton-coupled monocarboxylate transport | 1.560083e-01 | 0.807 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 1.655027e-01 | 0.781 |
| R-HSA-5693606 | DNA Double Strand Break Response | 5.410465e-02 | 1.267 |
| R-HSA-392170 | ADP signalling through P2Y purinoceptor 12 | 2.547949e-01 | 0.594 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 2.631837e-01 | 0.580 |
| R-HSA-6803529 | FGFR2 alternative splicing | 2.714786e-01 | 0.566 |
| R-HSA-428930 | Thromboxane signalling through TP receptor | 2.877907e-01 | 0.541 |
| R-HSA-5693538 | Homology Directed Repair | 6.385565e-02 | 1.195 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 3.065437e-02 | 1.514 |
| R-HSA-198753 | ERK/MAPK targets | 2.547949e-01 | 0.594 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 6.124407e-02 | 1.213 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 5.576057e-02 | 1.254 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 1.299420e-01 | 0.886 |
| R-HSA-456926 | Thrombin signalling through proteinase activated receptors (PARs) | 6.322618e-02 | 1.199 |
| R-HSA-8849473 | PTK6 Expression | 1.069007e-01 | 0.971 |
| R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 1.560083e-01 | 0.807 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 4.231731e-02 | 1.373 |
| R-HSA-391251 | Protein folding | 2.934880e-02 | 1.532 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 1.933532e-01 | 0.714 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 2.124215e-01 | 0.673 |
| R-HSA-392851 | Prostacyclin signalling through prostacyclin receptor | 2.377313e-01 | 0.624 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 2.714786e-01 | 0.566 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 2.622472e-01 | 0.581 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 1.031417e-01 | 0.987 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 2.248151e-01 | 0.648 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 7.911296e-02 | 1.102 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 2.083053e-01 | 0.681 |
| R-HSA-9636667 | Manipulation of host energy metabolism | 3.334139e-02 | 1.477 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 5.495240e-02 | 1.260 |
| R-HSA-69478 | G2/M DNA replication checkpoint | 9.674341e-02 | 1.014 |
| R-HSA-9032845 | Activated NTRK2 signals through CDK5 | 1.069007e-01 | 0.971 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 5.721579e-02 | 1.242 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 1.748909e-01 | 0.757 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 6.019489e-02 | 1.220 |
| R-HSA-9603798 | Class I peroxisomal membrane protein import | 2.024297e-01 | 0.694 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 7.911296e-02 | 1.102 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 7.911296e-02 | 1.102 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 2.290543e-01 | 0.640 |
| R-HSA-500657 | Presynaptic function of Kainate receptors | 2.290543e-01 | 0.640 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 5.238638e-02 | 1.281 |
| R-HSA-392451 | G beta:gamma signalling through PI3Kgamma | 2.796806e-01 | 0.553 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 1.878686e-01 | 0.726 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 1.500419e-01 | 0.824 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 7.261808e-02 | 1.139 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 3.703531e-02 | 1.431 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 1.394481e-01 | 0.856 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 7.584312e-02 | 1.120 |
| R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 2.877907e-01 | 0.541 |
| R-HSA-177929 | Signaling by EGFR | 1.637645e-01 | 0.786 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 1.103346e-01 | 0.957 |
| R-HSA-6807004 | Negative regulation of MET activity | 2.463111e-01 | 0.609 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 8.052853e-02 | 1.094 |
| R-HSA-450341 | Activation of the AP-1 family of transcription factors | 1.268758e-01 | 0.897 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 1.748909e-01 | 0.757 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 9.261268e-02 | 1.033 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 2.714786e-01 | 0.566 |
| R-HSA-8873719 | RAB geranylgeranylation | 1.797755e-01 | 0.745 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 2.289590e-01 | 0.640 |
| R-HSA-4086398 | Ca2+ pathway | 6.497059e-02 | 1.187 |
| R-HSA-1369062 | ABC transporters in lipid homeostasis | 4.315910e-02 | 1.365 |
| R-HSA-5683057 | MAPK family signaling cascades | 2.367907e-01 | 0.626 |
| R-HSA-429593 | Inositol transporters | 7.608287e-02 | 1.119 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 9.674341e-02 | 1.014 |
| R-HSA-9732724 | IFNG signaling activates MAPKs | 1.069007e-01 | 0.971 |
| R-HSA-111995 | phospho-PLA2 pathway | 1.169444e-01 | 0.932 |
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 1.366961e-01 | 0.864 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 1.841740e-01 | 0.735 |
| R-HSA-2142712 | Synthesis of 12-eicosatetraenoic acid derivatives | 1.933532e-01 | 0.714 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 7.584312e-02 | 1.120 |
| R-HSA-9834899 | Specification of the neural plate border | 2.377313e-01 | 0.624 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 2.547949e-01 | 0.594 |
| R-HSA-416482 | G alpha (12/13) signalling events | 7.472961e-02 | 1.127 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 2.877907e-01 | 0.541 |
| R-HSA-69481 | G2/M Checkpoints | 7.863579e-02 | 1.104 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 1.054747e-01 | 0.977 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 2.789222e-01 | 0.555 |
| R-HSA-195721 | Signaling by WNT | 7.081320e-02 | 1.150 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 1.326422e-01 | 0.877 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 2.289590e-01 | 0.640 |
| R-HSA-912446 | Meiotic recombination | 1.441514e-01 | 0.841 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 1.036877e-01 | 0.984 |
| R-HSA-9664417 | Leishmania phagocytosis | 1.036877e-01 | 0.984 |
| R-HSA-9664407 | Parasite infection | 1.036877e-01 | 0.984 |
| R-HSA-74749 | Signal attenuation | 1.366961e-01 | 0.864 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 6.019489e-02 | 1.220 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 8.242620e-02 | 1.084 |
| R-HSA-983189 | Kinesins | 4.265100e-02 | 1.370 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 7.261808e-02 | 1.139 |
| R-HSA-73894 | DNA Repair | 2.610667e-01 | 0.583 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 1.213602e-01 | 0.916 |
| R-HSA-8953854 | Metabolism of RNA | 1.729878e-01 | 0.762 |
| R-HSA-8941284 | RUNX2 regulates chondrocyte maturation | 7.608287e-02 | 1.119 |
| R-HSA-9842640 | Signaling by LTK in cancer | 9.674341e-02 | 1.014 |
| R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 1.169444e-01 | 0.932 |
| R-HSA-444257 | RSK activation | 1.169444e-01 | 0.932 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 1.655027e-01 | 0.781 |
| R-HSA-9796292 | Formation of axial mesoderm | 1.748909e-01 | 0.757 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 1.933532e-01 | 0.714 |
| R-HSA-9706369 | Negative regulation of FLT3 | 2.024297e-01 | 0.694 |
| R-HSA-2142770 | Synthesis of 15-eicosatetraenoic acid derivatives | 2.202792e-01 | 0.657 |
| R-HSA-2142688 | Synthesis of 5-eicosatetraenoic acids | 2.377313e-01 | 0.624 |
| R-HSA-8964038 | LDL clearance | 2.714786e-01 | 0.566 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 2.877907e-01 | 0.541 |
| R-HSA-445355 | Smooth Muscle Contraction | 1.519368e-01 | 0.818 |
| R-HSA-450294 | MAP kinase activation | 1.838155e-01 | 0.736 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 2.289590e-01 | 0.640 |
| R-HSA-1500620 | Meiosis | 2.830884e-01 | 0.548 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 1.180006e-01 | 0.928 |
| R-HSA-448424 | Interleukin-17 signaling | 2.206771e-01 | 0.656 |
| R-HSA-416476 | G alpha (q) signalling events | 2.198756e-01 | 0.658 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 1.031417e-01 | 0.987 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 2.622472e-01 | 0.581 |
| R-HSA-5654738 | Signaling by FGFR2 | 7.880522e-02 | 1.103 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 2.414196e-01 | 0.617 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 4.578554e-02 | 1.339 |
| R-HSA-397014 | Muscle contraction | 1.242865e-01 | 0.906 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 1.841740e-01 | 0.735 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 1.933532e-01 | 0.714 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 1.933532e-01 | 0.714 |
| R-HSA-1483148 | Synthesis of PG | 2.114047e-01 | 0.675 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 2.202792e-01 | 0.657 |
| R-HSA-190828 | Gap junction trafficking | 1.176550e-01 | 0.929 |
| R-HSA-9766229 | Degradation of CDH1 | 1.364547e-01 | 0.865 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 2.501695e-01 | 0.602 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 2.029041e-01 | 0.693 |
| R-HSA-69620 | Cell Cycle Checkpoints | 9.711988e-02 | 1.013 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 1.219675e-01 | 0.914 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 2.705858e-01 | 0.568 |
| R-HSA-9734767 | Developmental Cell Lineages | 2.178508e-01 | 0.662 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 1.422516e-01 | 0.847 |
| R-HSA-70171 | Glycolysis | 1.319711e-01 | 0.880 |
| R-HSA-5654743 | Signaling by FGFR4 | 1.139794e-01 | 0.943 |
| R-HSA-9634635 | Estrogen-stimulated signaling through PRKCZ | 1.268758e-01 | 0.897 |
| R-HSA-9627069 | Regulation of the apoptosome activity | 1.366961e-01 | 0.864 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 1.841740e-01 | 0.735 |
| R-HSA-9675151 | Disorders of Developmental Biology | 2.114047e-01 | 0.675 |
| R-HSA-71288 | Creatine metabolism | 2.463111e-01 | 0.609 |
| R-HSA-157858 | Gap junction trafficking and regulation | 1.364547e-01 | 0.865 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 2.796806e-01 | 0.553 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 1.554629e-01 | 0.808 |
| R-HSA-5654741 | Signaling by FGFR3 | 1.213602e-01 | 0.916 |
| R-HSA-9823730 | Formation of definitive endoderm | 2.463111e-01 | 0.609 |
| R-HSA-9659379 | Sensory processing of sound | 2.580784e-01 | 0.588 |
| R-HSA-111885 | Opioid Signalling | 4.246333e-02 | 1.372 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 2.631837e-01 | 0.580 |
| R-HSA-70326 | Glucose metabolism | 1.857659e-01 | 0.731 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 1.244414e-01 | 0.905 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 1.717968e-01 | 0.765 |
| R-HSA-9675135 | Diseases of DNA repair | 1.250939e-01 | 0.903 |
| R-HSA-5654736 | Signaling by FGFR1 | 1.637645e-01 | 0.786 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 2.289590e-01 | 0.640 |
| R-HSA-9635465 | Suppression of apoptosis | 1.464065e-01 | 0.834 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 2.202792e-01 | 0.657 |
| R-HSA-392517 | Rap1 signalling | 2.377313e-01 | 0.624 |
| R-HSA-193648 | NRAGE signals death through JNK | 1.637645e-01 | 0.786 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 1.269335e-01 | 0.896 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 2.124215e-01 | 0.673 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 1.269335e-01 | 0.896 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 1.269335e-01 | 0.896 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 5.941968e-02 | 1.226 |
| R-HSA-9824443 | Parasitic Infection Pathways | 1.277913e-01 | 0.893 |
| R-HSA-9658195 | Leishmania infection | 1.277913e-01 | 0.893 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 2.248151e-01 | 0.648 |
| R-HSA-190236 | Signaling by FGFR | 1.269335e-01 | 0.896 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 1.581503e-01 | 0.801 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 2.331081e-01 | 0.632 |
| R-HSA-4839726 | Chromatin organization | 1.901677e-01 | 0.721 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 1.608520e-01 | 0.794 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 1.914358e-01 | 0.718 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 2.547949e-01 | 0.594 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 2.547949e-01 | 0.594 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 1.608520e-01 | 0.794 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 1.914358e-01 | 0.718 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 2.000216e-01 | 0.699 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 8.020040e-02 | 1.096 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 1.474898e-01 | 0.831 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 1.841740e-01 | 0.735 |
| R-HSA-1433559 | Regulation of KIT signaling | 1.841740e-01 | 0.735 |
| R-HSA-977347 | Serine metabolism | 2.631837e-01 | 0.580 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 6.879925e-02 | 1.162 |
| R-HSA-166208 | mTORC1-mediated signalling | 2.714786e-01 | 0.566 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 1.637645e-01 | 0.786 |
| R-HSA-2682334 | EPH-Ephrin signaling | 1.098812e-01 | 0.959 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 2.000216e-01 | 0.699 |
| R-HSA-109582 | Hemostasis | 4.051370e-02 | 1.392 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 1.797755e-01 | 0.745 |
| R-HSA-70263 | Gluconeogenesis | 1.326422e-01 | 0.877 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 1.690405e-01 | 0.772 |
| R-HSA-6806834 | Signaling by MET | 2.622472e-01 | 0.581 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 1.773478e-01 | 0.751 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 1.919342e-01 | 0.717 |
| R-HSA-8848021 | Signaling by PTK6 | 1.919342e-01 | 0.717 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 3.545604e-02 | 1.450 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 6.943927e-02 | 1.158 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 2.377313e-01 | 0.624 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 2.351965e-01 | 0.629 |
| R-HSA-1640170 | Cell Cycle | 2.042234e-01 | 0.690 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 1.169444e-01 | 0.932 |
| R-HSA-111458 | Formation of apoptosome | 1.366961e-01 | 0.864 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 1.748909e-01 | 0.757 |
| R-HSA-1502540 | Signaling by Activin | 1.933532e-01 | 0.714 |
| R-HSA-210991 | Basigin interactions | 2.547949e-01 | 0.594 |
| R-HSA-166520 | Signaling by NTRKs | 4.130231e-02 | 1.384 |
| R-HSA-3247509 | Chromatin modifying enzymes | 1.620616e-01 | 0.790 |
| R-HSA-112043 | PLC beta mediated events | 1.838155e-01 | 0.736 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 2.290543e-01 | 0.640 |
| R-HSA-1483255 | PI Metabolism | 1.370779e-01 | 0.863 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 2.206771e-01 | 0.656 |
| R-HSA-422475 | Axon guidance | 5.787665e-02 | 1.237 |
| R-HSA-111461 | Cytochrome c-mediated apoptotic response | 1.560083e-01 | 0.807 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 5.721579e-02 | 1.242 |
| R-HSA-418885 | DCC mediated attractive signaling | 1.933532e-01 | 0.714 |
| R-HSA-1181150 | Signaling by NODAL | 2.463111e-01 | 0.609 |
| R-HSA-9675108 | Nervous system development | 8.195751e-02 | 1.086 |
| R-HSA-112040 | G-protein mediated events | 2.083053e-01 | 0.681 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 2.714786e-01 | 0.566 |
| R-HSA-156711 | Polo-like kinase mediated events | 2.290543e-01 | 0.640 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 1.031417e-01 | 0.987 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 1.139794e-01 | 0.943 |
| R-HSA-9824439 | Bacterial Infection Pathways | 1.856249e-01 | 0.731 |
| R-HSA-5633007 | Regulation of TP53 Activity | 1.440104e-01 | 0.842 |
| R-HSA-74259 | Purine catabolism | 2.289590e-01 | 0.640 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 2.331081e-01 | 0.632 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 2.202792e-01 | 0.657 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 2.202792e-01 | 0.657 |
| R-HSA-1474244 | Extracellular matrix organization | 4.726471e-02 | 1.325 |
| R-HSA-9006936 | Signaling by TGFB family members | 5.271508e-02 | 1.278 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 2.377313e-01 | 0.624 |
| R-HSA-1059683 | Interleukin-6 signaling | 1.748909e-01 | 0.757 |
| R-HSA-9013694 | Signaling by NOTCH4 | 2.372618e-01 | 0.625 |
| R-HSA-201556 | Signaling by ALK | 9.608601e-02 | 1.017 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 3.374566e-02 | 1.472 |
| R-HSA-449147 | Signaling by Interleukins | 1.974589e-01 | 0.705 |
| R-HSA-2132295 | MHC class II antigen presentation | 2.029041e-01 | 0.693 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 1.914358e-01 | 0.718 |
| R-HSA-111471 | Apoptotic factor-mediated response | 2.290543e-01 | 0.640 |
| R-HSA-982772 | Growth hormone receptor signaling | 2.796806e-01 | 0.553 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 1.480335e-01 | 0.830 |
| R-HSA-6783589 | Interleukin-6 family signaling | 2.877907e-01 | 0.541 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 2.896752e-01 | 0.538 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 2.914141e-01 | 0.535 |
| R-HSA-997272 | Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | 2.958101e-01 | 0.529 |
| R-HSA-1296041 | Activation of G protein gated Potassium channels | 2.958101e-01 | 0.529 |
| R-HSA-1296059 | G protein gated Potassium channels | 2.958101e-01 | 0.529 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 2.958101e-01 | 0.529 |
| R-HSA-3000157 | Laminin interactions | 2.958101e-01 | 0.529 |
| R-HSA-420029 | Tight junction interactions | 2.958101e-01 | 0.529 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 2.958101e-01 | 0.529 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 2.958101e-01 | 0.529 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 2.958101e-01 | 0.529 |
| R-HSA-9830364 | Formation of the nephric duct | 2.958101e-01 | 0.529 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 3.019393e-01 | 0.520 |
| R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | 3.037396e-01 | 0.517 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 3.037396e-01 | 0.517 |
| R-HSA-8874081 | MET activates PTK2 signaling | 3.037396e-01 | 0.517 |
| R-HSA-1855183 | Synthesis of IP2, IP, and Ins in the cytosol | 3.037396e-01 | 0.517 |
| R-HSA-9638630 | Attachment of bacteria to epithelial cells | 3.037396e-01 | 0.517 |
| R-HSA-2046105 | Linoleic acid (LA) metabolism | 3.037396e-01 | 0.517 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 3.037396e-01 | 0.517 |
| R-HSA-68886 | M Phase | 3.054734e-01 | 0.515 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 3.080819e-01 | 0.511 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 3.080819e-01 | 0.511 |
| R-HSA-171306 | Packaging Of Telomere Ends | 3.115804e-01 | 0.506 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 3.115804e-01 | 0.506 |
| R-HSA-8949613 | Cristae formation | 3.115804e-01 | 0.506 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 3.115804e-01 | 0.506 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 3.115804e-01 | 0.506 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 3.163053e-01 | 0.500 |
| R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 3.193333e-01 | 0.496 |
| R-HSA-5334118 | DNA methylation | 3.269994e-01 | 0.485 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 3.269994e-01 | 0.485 |
| R-HSA-420092 | Glucagon-type ligand receptors | 3.269994e-01 | 0.485 |
| R-HSA-418360 | Platelet calcium homeostasis | 3.269994e-01 | 0.485 |
| R-HSA-180024 | DARPP-32 events | 3.269994e-01 | 0.485 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 3.345796e-01 | 0.476 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 3.345796e-01 | 0.476 |
| R-HSA-157118 | Signaling by NOTCH | 3.388936e-01 | 0.470 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 3.420749e-01 | 0.466 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 3.420749e-01 | 0.466 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 3.420749e-01 | 0.466 |
| R-HSA-199991 | Membrane Trafficking | 3.451349e-01 | 0.462 |
| R-HSA-69278 | Cell Cycle, Mitotic | 3.459619e-01 | 0.461 |
| R-HSA-422356 | Regulation of insulin secretion | 3.491689e-01 | 0.457 |
| R-HSA-1296065 | Inwardly rectifying K+ channels | 3.494862e-01 | 0.457 |
| R-HSA-4791275 | Signaling by WNT in cancer | 3.494862e-01 | 0.457 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 3.494862e-01 | 0.457 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 3.494862e-01 | 0.457 |
| R-HSA-3214847 | HATs acetylate histones | 3.532423e-01 | 0.452 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 3.532423e-01 | 0.452 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 3.568145e-01 | 0.448 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 3.568145e-01 | 0.448 |
| R-HSA-5083635 | Defective B3GALTL causes PpS | 3.568145e-01 | 0.448 |
| R-HSA-397795 | G-protein beta:gamma signalling | 3.568145e-01 | 0.448 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 3.568145e-01 | 0.448 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 3.568145e-01 | 0.448 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 3.568145e-01 | 0.448 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 3.568145e-01 | 0.448 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 3.568145e-01 | 0.448 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 3.568145e-01 | 0.448 |
| R-HSA-9733709 | Cardiogenesis | 3.568145e-01 | 0.448 |
| R-HSA-354192 | Integrin signaling | 3.568145e-01 | 0.448 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 3.573069e-01 | 0.447 |
| R-HSA-5610787 | Hedgehog 'off' state | 3.573069e-01 | 0.447 |
| R-HSA-382556 | ABC-family proteins mediated transport | 3.573069e-01 | 0.447 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 3.603275e-01 | 0.443 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 3.613624e-01 | 0.442 |
| R-HSA-9020702 | Interleukin-1 signaling | 3.613624e-01 | 0.442 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 3.640607e-01 | 0.439 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 3.640607e-01 | 0.439 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 3.640607e-01 | 0.439 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 3.640607e-01 | 0.439 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 3.640607e-01 | 0.439 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 3.640607e-01 | 0.439 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 3.654084e-01 | 0.437 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 3.654084e-01 | 0.437 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 3.664526e-01 | 0.436 |
| R-HSA-392518 | Signal amplification | 3.712257e-01 | 0.430 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 3.712257e-01 | 0.430 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 3.712257e-01 | 0.430 |
| R-HSA-180746 | Nuclear import of Rev protein | 3.712257e-01 | 0.430 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 3.712257e-01 | 0.430 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 3.712257e-01 | 0.430 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 3.734711e-01 | 0.428 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 3.774871e-01 | 0.423 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 3.774871e-01 | 0.423 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 3.783104e-01 | 0.422 |
| R-HSA-2559585 | Oncogene Induced Senescence | 3.783104e-01 | 0.422 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 3.783104e-01 | 0.422 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 3.783104e-01 | 0.422 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 3.853157e-01 | 0.414 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 3.853157e-01 | 0.414 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 3.853157e-01 | 0.414 |
| R-HSA-74158 | RNA Polymerase III Transcription | 3.853157e-01 | 0.414 |
| R-HSA-9682385 | FLT3 signaling in disease | 3.853157e-01 | 0.414 |
| R-HSA-418346 | Platelet homeostasis | 3.854871e-01 | 0.414 |
| R-HSA-211000 | Gene Silencing by RNA | 3.894706e-01 | 0.410 |
| R-HSA-2559583 | Cellular Senescence | 3.908444e-01 | 0.408 |
| R-HSA-5173214 | O-glycosylation of TSR domain-containing proteins | 3.922425e-01 | 0.406 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 3.922425e-01 | 0.406 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 3.922425e-01 | 0.406 |
| R-HSA-110331 | Cleavage of the damaged purine | 3.922425e-01 | 0.406 |
| R-HSA-390247 | Beta-oxidation of very long chain fatty acids | 3.922425e-01 | 0.406 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 3.934427e-01 | 0.405 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 3.934427e-01 | 0.405 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 3.934427e-01 | 0.405 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 3.974031e-01 | 0.401 |
| R-HSA-73927 | Depurination | 3.990917e-01 | 0.399 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 3.990917e-01 | 0.399 |
| R-HSA-9931953 | Biofilm formation | 3.990917e-01 | 0.399 |
| R-HSA-8875878 | MET promotes cell motility | 3.990917e-01 | 0.399 |
| R-HSA-2046106 | alpha-linolenic acid (ALA) metabolism | 3.990917e-01 | 0.399 |
| R-HSA-74160 | Gene expression (Transcription) | 3.998005e-01 | 0.398 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 4.058641e-01 | 0.392 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 4.058641e-01 | 0.392 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 4.058641e-01 | 0.392 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 4.058641e-01 | 0.392 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 4.058641e-01 | 0.392 |
| R-HSA-71336 | Pentose phosphate pathway | 4.058641e-01 | 0.392 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 4.092125e-01 | 0.388 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 4.092125e-01 | 0.388 |
| R-HSA-1483249 | Inositol phosphate metabolism | 4.092125e-01 | 0.388 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 4.125605e-01 | 0.385 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 4.125605e-01 | 0.385 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 4.125605e-01 | 0.385 |
| R-HSA-9854311 | Maturation of TCA enzymes and regulation of TCA cycle | 4.125605e-01 | 0.385 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 4.125605e-01 | 0.385 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 4.125605e-01 | 0.385 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 4.150028e-01 | 0.382 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 4.191820e-01 | 0.378 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 4.191820e-01 | 0.378 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 4.191820e-01 | 0.378 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 4.191820e-01 | 0.378 |
| R-HSA-9607240 | FLT3 Signaling | 4.191820e-01 | 0.378 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 4.191820e-01 | 0.378 |
| R-HSA-168898 | Toll-like Receptor Cascades | 4.239869e-01 | 0.373 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 4.257292e-01 | 0.371 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 4.286413e-01 | 0.368 |
| R-HSA-68877 | Mitotic Prometaphase | 4.299505e-01 | 0.367 |
| R-HSA-991365 | Activation of GABAB receptors | 4.322030e-01 | 0.364 |
| R-HSA-977444 | GABA B receptor activation | 4.322030e-01 | 0.364 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 4.322030e-01 | 0.364 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 4.322030e-01 | 0.364 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 4.322030e-01 | 0.364 |
| R-HSA-73928 | Depyrimidination | 4.322030e-01 | 0.364 |
| R-HSA-111996 | Ca-dependent events | 4.322030e-01 | 0.364 |
| R-HSA-165159 | MTOR signalling | 4.322030e-01 | 0.364 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 4.324872e-01 | 0.364 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 4.324872e-01 | 0.364 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 4.329242e-01 | 0.364 |
| R-HSA-1592230 | Mitochondrial biogenesis | 4.363194e-01 | 0.360 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 4.379043e-01 | 0.359 |
| R-HSA-9710421 | Defective pyroptosis | 4.386042e-01 | 0.358 |
| R-HSA-73621 | Pyrimidine catabolism | 4.386042e-01 | 0.358 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 4.386042e-01 | 0.358 |
| R-HSA-1433557 | Signaling by SCF-KIT | 4.386042e-01 | 0.358 |
| R-HSA-69236 | G1 Phase | 4.449336e-01 | 0.352 |
| R-HSA-69231 | Cyclin D associated events in G1 | 4.449336e-01 | 0.352 |
| R-HSA-3214858 | RMTs methylate histone arginines | 4.449336e-01 | 0.352 |
| R-HSA-373752 | Netrin-1 signaling | 4.449336e-01 | 0.352 |
| R-HSA-8953897 | Cellular responses to stimuli | 4.472615e-01 | 0.349 |
| R-HSA-389948 | Co-inhibition by PD-1 | 4.506452e-01 | 0.346 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 4.506452e-01 | 0.346 |
| R-HSA-774815 | Nucleosome assembly | 4.511921e-01 | 0.346 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 4.511921e-01 | 0.346 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 4.511921e-01 | 0.346 |
| R-HSA-9824272 | Somitogenesis | 4.511921e-01 | 0.346 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 4.511921e-01 | 0.346 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 4.511921e-01 | 0.346 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 4.511921e-01 | 0.346 |
| R-HSA-1489509 | DAG and IP3 signaling | 4.511921e-01 | 0.346 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 4.511921e-01 | 0.346 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 4.515073e-01 | 0.345 |
| R-HSA-3371556 | Cellular response to heat stress | 4.515073e-01 | 0.345 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 4.515073e-01 | 0.345 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 4.515073e-01 | 0.345 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 4.573804e-01 | 0.340 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 4.573804e-01 | 0.340 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 4.573804e-01 | 0.340 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 4.573804e-01 | 0.340 |
| R-HSA-75153 | Apoptotic execution phase | 4.573804e-01 | 0.340 |
| R-HSA-376176 | Signaling by ROBO receptors | 4.594226e-01 | 0.338 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 4.594226e-01 | 0.338 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 4.634992e-01 | 0.334 |
| R-HSA-2046104 | alpha-linolenic (omega3) and linoleic (omega6) acid metabolism | 4.634992e-01 | 0.334 |
| R-HSA-72172 | mRNA Splicing | 4.652414e-01 | 0.332 |
| R-HSA-1266738 | Developmental Biology | 4.654549e-01 | 0.332 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 4.684349e-01 | 0.329 |
| R-HSA-9634597 | GPER1 signaling | 4.695495e-01 | 0.328 |
| R-HSA-9031628 | NGF-stimulated transcription | 4.695495e-01 | 0.328 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 4.711545e-01 | 0.327 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 4.755319e-01 | 0.323 |
| R-HSA-1483257 | Phospholipid metabolism | 4.774838e-01 | 0.321 |
| R-HSA-114608 | Platelet degranulation | 4.775201e-01 | 0.321 |
| R-HSA-8956319 | Nucleotide catabolism | 4.848146e-01 | 0.314 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 4.872961e-01 | 0.312 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 4.910778e-01 | 0.309 |
| R-HSA-1474165 | Reproduction | 4.920462e-01 | 0.308 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 4.930795e-01 | 0.307 |
| R-HSA-6794361 | Neurexins and neuroligins | 4.930795e-01 | 0.307 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 4.930795e-01 | 0.307 |
| R-HSA-1221632 | Meiotic synapsis | 4.987979e-01 | 0.302 |
| R-HSA-8956320 | Nucleotide biosynthesis | 4.987979e-01 | 0.302 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 5.027737e-01 | 0.299 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 5.044522e-01 | 0.297 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 5.044522e-01 | 0.297 |
| R-HSA-418597 | G alpha (z) signalling events | 5.100430e-01 | 0.292 |
| R-HSA-212436 | Generic Transcription Pathway | 5.142950e-01 | 0.289 |
| R-HSA-5578775 | Ion homeostasis | 5.155712e-01 | 0.288 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 5.155712e-01 | 0.288 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 5.155712e-01 | 0.288 |
| R-HSA-163685 | Integration of energy metabolism | 5.168494e-01 | 0.287 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 5.210372e-01 | 0.283 |
| R-HSA-1483166 | Synthesis of PA | 5.210372e-01 | 0.283 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 5.210372e-01 | 0.283 |
| R-HSA-5358351 | Signaling by Hedgehog | 5.237882e-01 | 0.281 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 5.272897e-01 | 0.278 |
| R-HSA-191859 | snRNP Assembly | 5.317861e-01 | 0.274 |
| R-HSA-194441 | Metabolism of non-coding RNA | 5.317861e-01 | 0.274 |
| R-HSA-418594 | G alpha (i) signalling events | 5.325624e-01 | 0.274 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 5.327352e-01 | 0.273 |
| R-HSA-977443 | GABA receptor activation | 5.370702e-01 | 0.270 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 5.370702e-01 | 0.270 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 5.408420e-01 | 0.267 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 5.422949e-01 | 0.266 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 5.422949e-01 | 0.266 |
| R-HSA-445717 | Aquaporin-mediated transport | 5.422949e-01 | 0.266 |
| R-HSA-72312 | rRNA processing | 5.435208e-01 | 0.265 |
| R-HSA-6784531 | tRNA processing in the nucleus | 5.474611e-01 | 0.262 |
| R-HSA-1268020 | Mitochondrial protein import | 5.474611e-01 | 0.262 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 5.474611e-01 | 0.262 |
| R-HSA-9707616 | Heme signaling | 5.474611e-01 | 0.262 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 5.474611e-01 | 0.262 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 5.525692e-01 | 0.258 |
| R-HSA-15869 | Metabolism of nucleotides | 5.541625e-01 | 0.256 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 5.541799e-01 | 0.256 |
| R-HSA-8939211 | ESR-mediated signaling | 5.568000e-01 | 0.254 |
| R-HSA-74751 | Insulin receptor signalling cascade | 5.576200e-01 | 0.254 |
| R-HSA-9758941 | Gastrulation | 5.640034e-01 | 0.249 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 5.672435e-01 | 0.246 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 5.704663e-01 | 0.244 |
| R-HSA-9830369 | Kidney development | 5.724347e-01 | 0.242 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 5.736718e-01 | 0.241 |
| R-HSA-446652 | Interleukin-1 family signaling | 5.736718e-01 | 0.241 |
| R-HSA-9609507 | Protein localization | 5.768600e-01 | 0.239 |
| R-HSA-73887 | Death Receptor Signaling | 5.800308e-01 | 0.237 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 5.826591e-01 | 0.235 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 5.831843e-01 | 0.234 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 5.867559e-01 | 0.232 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 5.867559e-01 | 0.232 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 5.867559e-01 | 0.232 |
| R-HSA-5632684 | Hedgehog 'on' state | 5.914228e-01 | 0.228 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 5.914228e-01 | 0.228 |
| R-HSA-3000178 | ECM proteoglycans | 5.914228e-01 | 0.228 |
| R-HSA-975634 | Retinoid metabolism and transport | 5.914228e-01 | 0.228 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 5.925407e-01 | 0.227 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 5.960373e-01 | 0.225 |
| R-HSA-5653656 | Vesicle-mediated transport | 5.965161e-01 | 0.224 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 6.006000e-01 | 0.221 |
| R-HSA-9749641 | Aspirin ADME | 6.006000e-01 | 0.221 |
| R-HSA-5688426 | Deubiquitination | 6.026520e-01 | 0.220 |
| R-HSA-109581 | Apoptosis | 6.047726e-01 | 0.218 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 6.051067e-01 | 0.218 |
| R-HSA-2467813 | Separation of Sister Chromatids | 6.107843e-01 | 0.214 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 6.139827e-01 | 0.212 |
| R-HSA-5689603 | UCH proteinases | 6.139827e-01 | 0.212 |
| R-HSA-1980143 | Signaling by NOTCH1 | 6.139827e-01 | 0.212 |
| R-HSA-5619102 | SLC transporter disorders | 6.196715e-01 | 0.208 |
| R-HSA-73864 | RNA Polymerase I Transcription | 6.226558e-01 | 0.206 |
| R-HSA-9955298 | SLC-mediated transport of organic anions | 6.226558e-01 | 0.206 |
| R-HSA-5619084 | ABC transporter disorders | 6.226558e-01 | 0.206 |
| R-HSA-216083 | Integrin cell surface interactions | 6.226558e-01 | 0.206 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 6.269194e-01 | 0.203 |
| R-HSA-2262752 | Cellular responses to stress | 6.316516e-01 | 0.200 |
| R-HSA-9711123 | Cellular response to chemical stress | 6.337807e-01 | 0.198 |
| R-HSA-418555 | G alpha (s) signalling events | 6.341372e-01 | 0.198 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 6.353034e-01 | 0.197 |
| R-HSA-977225 | Amyloid fiber formation | 6.353034e-01 | 0.197 |
| R-HSA-6806667 | Metabolism of fat-soluble vitamins | 6.353034e-01 | 0.197 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 6.394249e-01 | 0.194 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 6.398027e-01 | 0.194 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 6.398027e-01 | 0.194 |
| R-HSA-5689880 | Ub-specific processing proteases | 6.398027e-01 | 0.194 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 6.475294e-01 | 0.189 |
| R-HSA-390918 | Peroxisomal lipid metabolism | 6.475294e-01 | 0.189 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 6.515134e-01 | 0.186 |
| R-HSA-611105 | Respiratory electron transport | 6.536661e-01 | 0.185 |
| R-HSA-168255 | Influenza Infection | 6.563876e-01 | 0.183 |
| R-HSA-438064 | Post NMDA receptor activation events | 6.631988e-01 | 0.178 |
| R-HSA-73857 | RNA Polymerase II Transcription | 6.652567e-01 | 0.177 |
| R-HSA-1280218 | Adaptive Immune System | 6.663443e-01 | 0.176 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 6.670066e-01 | 0.176 |
| R-HSA-156902 | Peptide chain elongation | 6.670066e-01 | 0.176 |
| R-HSA-420499 | Class C/3 (Metabotropic glutamate/pheromone receptors) | 6.670066e-01 | 0.176 |
| R-HSA-9645723 | Diseases of programmed cell death | 6.670066e-01 | 0.176 |
| R-HSA-913531 | Interferon Signaling | 6.720181e-01 | 0.173 |
| R-HSA-112310 | Neurotransmitter release cycle | 6.744944e-01 | 0.171 |
| R-HSA-73884 | Base Excision Repair | 6.744944e-01 | 0.171 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 6.744944e-01 | 0.171 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 6.781753e-01 | 0.169 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 6.781753e-01 | 0.169 |
| R-HSA-388396 | GPCR downstream signalling | 6.802985e-01 | 0.167 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 6.854132e-01 | 0.164 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 6.854132e-01 | 0.164 |
| R-HSA-74752 | Signaling by Insulin receptor | 6.854132e-01 | 0.164 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 6.889713e-01 | 0.162 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 6.889713e-01 | 0.162 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 6.959677e-01 | 0.157 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 6.959677e-01 | 0.157 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 6.994070e-01 | 0.155 |
| R-HSA-72764 | Eukaryotic Translation Termination | 6.994070e-01 | 0.155 |
| R-HSA-9609690 | HCMV Early Events | 7.000842e-01 | 0.155 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 7.028076e-01 | 0.153 |
| R-HSA-1296071 | Potassium Channels | 7.028076e-01 | 0.153 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 7.028076e-01 | 0.153 |
| R-HSA-157579 | Telomere Maintenance | 7.061700e-01 | 0.151 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 7.094945e-01 | 0.149 |
| R-HSA-2408557 | Selenocysteine synthesis | 7.192452e-01 | 0.143 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 7.224226e-01 | 0.141 |
| R-HSA-5357801 | Programmed Cell Death | 7.235826e-01 | 0.141 |
| R-HSA-192823 | Viral mRNA Translation | 7.255642e-01 | 0.139 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 7.286705e-01 | 0.137 |
| R-HSA-5696398 | Nucleotide Excision Repair | 7.347784e-01 | 0.134 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 7.377809e-01 | 0.132 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 7.390969e-01 | 0.131 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 7.407496e-01 | 0.130 |
| R-HSA-112315 | Transmission across Chemical Synapses | 7.464040e-01 | 0.127 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 7.465871e-01 | 0.127 |
| R-HSA-68882 | Mitotic Anaphase | 7.476263e-01 | 0.126 |
| R-HSA-5663205 | Infectious disease | 7.479959e-01 | 0.126 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 7.497212e-01 | 0.125 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 7.550991e-01 | 0.122 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 7.578728e-01 | 0.120 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 7.633268e-01 | 0.117 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 7.660078e-01 | 0.116 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 7.686585e-01 | 0.114 |
| R-HSA-2980736 | Peptide hormone metabolism | 7.738708e-01 | 0.111 |
| R-HSA-372790 | Signaling by GPCR | 7.803354e-01 | 0.108 |
| R-HSA-73886 | Chromosome Maintenance | 7.839476e-01 | 0.106 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 7.885704e-01 | 0.103 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 7.885860e-01 | 0.103 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 7.888173e-01 | 0.103 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 7.892039e-01 | 0.103 |
| R-HSA-6809371 | Formation of the cornified envelope | 7.912110e-01 | 0.102 |
| R-HSA-162909 | Host Interactions of HIV factors | 7.912110e-01 | 0.102 |
| R-HSA-69206 | G1/S Transition | 7.959178e-01 | 0.099 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 7.982315e-01 | 0.098 |
| R-HSA-112316 | Neuronal System | 8.056651e-01 | 0.094 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 8.072282e-01 | 0.093 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 8.096754e-01 | 0.092 |
| R-HSA-9609646 | HCMV Infection | 8.109233e-01 | 0.091 |
| R-HSA-5576891 | Cardiac conduction | 8.115758e-01 | 0.091 |
| R-HSA-9909396 | Circadian clock | 8.137129e-01 | 0.090 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 8.137129e-01 | 0.090 |
| R-HSA-1643685 | Disease | 8.213627e-01 | 0.085 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 8.240421e-01 | 0.084 |
| R-HSA-5173105 | O-linked glycosylation | 8.260385e-01 | 0.083 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 8.260385e-01 | 0.083 |
| R-HSA-9948299 | Ribosome-associated quality control | 8.280125e-01 | 0.082 |
| R-HSA-6807070 | PTEN Regulation | 8.299641e-01 | 0.081 |
| R-HSA-1632852 | Macroautophagy | 8.338015e-01 | 0.079 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 8.375529e-01 | 0.077 |
| R-HSA-168256 | Immune System | 8.394698e-01 | 0.076 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 8.412200e-01 | 0.075 |
| R-HSA-168249 | Innate Immune System | 8.431794e-01 | 0.074 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 8.465668e-01 | 0.072 |
| R-HSA-2187338 | Visual phototransduction | 8.465668e-01 | 0.072 |
| R-HSA-69242 | S Phase | 8.483090e-01 | 0.071 |
| R-HSA-2142753 | Arachidonate metabolism | 8.550831e-01 | 0.068 |
| R-HSA-69306 | DNA Replication | 8.567291e-01 | 0.067 |
| R-HSA-9612973 | Autophagy | 8.615564e-01 | 0.065 |
| R-HSA-9610379 | HCMV Late Events | 8.631293e-01 | 0.064 |
| R-HSA-162587 | HIV Life Cycle | 8.631293e-01 | 0.064 |
| R-HSA-9711097 | Cellular response to starvation | 8.646843e-01 | 0.063 |
| R-HSA-877300 | Interferon gamma signaling | 8.662219e-01 | 0.062 |
| R-HSA-2408522 | Selenoamino acid metabolism | 8.736527e-01 | 0.059 |
| R-HSA-72306 | tRNA processing | 8.833711e-01 | 0.054 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 8.846974e-01 | 0.053 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 8.898541e-01 | 0.051 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 8.986783e-01 | 0.046 |
| R-HSA-3781865 | Diseases of glycosylation | 9.006334e-01 | 0.045 |
| R-HSA-69275 | G2/M Transition | 9.028825e-01 | 0.044 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 9.050810e-01 | 0.043 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.165039e-01 | 0.038 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 9.172750e-01 | 0.038 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 9.191447e-01 | 0.037 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 9.200660e-01 | 0.036 |
| R-HSA-9640148 | Infection with Enterobacteria | 9.200660e-01 | 0.036 |
| R-HSA-6805567 | Keratinization | 9.236480e-01 | 0.034 |
| R-HSA-9748784 | Drug ADME | 9.334639e-01 | 0.030 |
| R-HSA-8951664 | Neddylation | 9.357150e-01 | 0.029 |
| R-HSA-382551 | Transport of small molecules | 9.396664e-01 | 0.027 |
| R-HSA-162906 | HIV Infection | 9.399925e-01 | 0.027 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 9.413544e-01 | 0.026 |
| R-HSA-597592 | Post-translational protein modification | 9.486450e-01 | 0.023 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.512112e-01 | 0.022 |
| R-HSA-392499 | Metabolism of proteins | 9.553245e-01 | 0.020 |
| R-HSA-8978868 | Fatty acid metabolism | 9.556727e-01 | 0.020 |
| R-HSA-9679506 | SARS-CoV Infections | 9.598177e-01 | 0.018 |
| R-HSA-72766 | Translation | 9.641601e-01 | 0.016 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 9.681172e-01 | 0.014 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 9.725527e-01 | 0.012 |
| R-HSA-6798695 | Neutrophil degranulation | 9.727338e-01 | 0.012 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.769033e-01 | 0.010 |
| R-HSA-8957322 | Metabolism of steroids | 9.803583e-01 | 0.009 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.876320e-01 | 0.005 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 9.901901e-01 | 0.004 |
| R-HSA-500792 | GPCR ligand binding | 9.927618e-01 | 0.003 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.937617e-01 | 0.003 |
| R-HSA-5668914 | Diseases of metabolism | 9.941140e-01 | 0.003 |
| R-HSA-9824446 | Viral Infection Pathways | 9.970132e-01 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 9.986355e-01 | 0.001 |
| R-HSA-9709957 | Sensory Perception | 9.999499e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999612e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.849 | 0.207 | 2 | 0.863 |
CLK3 |
0.840 | 0.163 | 1 | 0.629 |
KIS |
0.839 | 0.158 | 1 | 0.566 |
MTOR |
0.833 | 0.119 | 1 | 0.641 |
IKKE |
0.830 | 0.275 | 1 | 0.676 |
GRK1 |
0.830 | 0.216 | -2 | 0.845 |
TBK1 |
0.830 | 0.254 | 1 | 0.662 |
MOS |
0.830 | 0.107 | 1 | 0.613 |
SRPK1 |
0.829 | 0.134 | -3 | 0.669 |
IKKB |
0.829 | 0.127 | -2 | 0.723 |
DSTYK |
0.828 | 0.135 | 2 | 0.878 |
NLK |
0.827 | 0.104 | 1 | 0.660 |
MST4 |
0.826 | 0.185 | 2 | 0.879 |
RAF1 |
0.824 | 0.194 | 1 | 0.684 |
CDC7 |
0.823 | -0.033 | 1 | 0.580 |
PRPK |
0.822 | -0.017 | -1 | 0.850 |
MLK1 |
0.822 | 0.110 | 2 | 0.838 |
GCN2 |
0.821 | -0.066 | 2 | 0.799 |
CDK1 |
0.821 | 0.114 | 1 | 0.522 |
CHAK2 |
0.820 | 0.074 | -1 | 0.827 |
CDKL1 |
0.819 | 0.039 | -3 | 0.710 |
PIM3 |
0.819 | -0.003 | -3 | 0.750 |
SRPK2 |
0.819 | 0.107 | -3 | 0.599 |
PDHK4 |
0.818 | -0.001 | 1 | 0.676 |
SRPK3 |
0.818 | 0.140 | -3 | 0.656 |
ATR |
0.817 | -0.011 | 1 | 0.618 |
CDK5 |
0.817 | 0.119 | 1 | 0.554 |
HIPK4 |
0.817 | 0.036 | 1 | 0.622 |
NEK6 |
0.817 | 0.006 | -2 | 0.790 |
IKKA |
0.816 | 0.077 | -2 | 0.719 |
ULK2 |
0.816 | -0.037 | 2 | 0.792 |
PKCD |
0.816 | 0.096 | 2 | 0.820 |
BMPR2 |
0.816 | 0.015 | -2 | 0.822 |
ERK5 |
0.815 | -0.008 | 1 | 0.589 |
CDK8 |
0.815 | 0.038 | 1 | 0.533 |
PDHK1 |
0.815 | 0.073 | 1 | 0.697 |
CDK19 |
0.814 | 0.048 | 1 | 0.510 |
CAMK2G |
0.814 | -0.029 | 2 | 0.809 |
PKN3 |
0.814 | 0.010 | -3 | 0.722 |
CDK13 |
0.814 | 0.080 | 1 | 0.543 |
CDKL5 |
0.814 | 0.024 | -3 | 0.696 |
BCKDK |
0.814 | 0.093 | -1 | 0.812 |
CK1E |
0.813 | 0.249 | -3 | 0.724 |
NDR2 |
0.813 | -0.032 | -3 | 0.745 |
TGFBR2 |
0.813 | 0.014 | -2 | 0.757 |
MLK3 |
0.813 | 0.076 | 2 | 0.783 |
NEK7 |
0.813 | -0.013 | -3 | 0.749 |
PKN2 |
0.813 | 0.062 | -3 | 0.729 |
CDK3 |
0.812 | 0.111 | 1 | 0.481 |
GRK5 |
0.812 | -0.012 | -3 | 0.815 |
ICK |
0.812 | 0.045 | -3 | 0.737 |
GRK7 |
0.811 | 0.118 | 1 | 0.549 |
CK1G1 |
0.811 | 0.271 | -3 | 0.715 |
HIPK2 |
0.811 | 0.080 | 1 | 0.510 |
WNK1 |
0.811 | 0.038 | -2 | 0.810 |
NIK |
0.810 | 0.014 | -3 | 0.773 |
CAMK1B |
0.810 | -0.063 | -3 | 0.748 |
CDK18 |
0.810 | 0.069 | 1 | 0.505 |
RIPK3 |
0.809 | -0.014 | 3 | 0.691 |
PRKD1 |
0.809 | -0.005 | -3 | 0.711 |
CDK12 |
0.809 | 0.080 | 1 | 0.528 |
GRK6 |
0.808 | 0.032 | 1 | 0.594 |
BMPR1B |
0.808 | 0.071 | 1 | 0.515 |
PKCG |
0.808 | 0.093 | 2 | 0.772 |
CK1D |
0.808 | 0.261 | -3 | 0.686 |
IRE1 |
0.808 | 0.047 | 1 | 0.577 |
JNK2 |
0.808 | 0.079 | 1 | 0.533 |
ERK1 |
0.808 | 0.073 | 1 | 0.521 |
DYRK2 |
0.808 | 0.039 | 1 | 0.563 |
CLK2 |
0.808 | 0.110 | -3 | 0.665 |
PIM1 |
0.808 | 0.010 | -3 | 0.699 |
PKCA |
0.807 | 0.104 | 2 | 0.767 |
JNK3 |
0.807 | 0.069 | 1 | 0.546 |
PKCB |
0.807 | 0.072 | 2 | 0.775 |
FAM20C |
0.807 | 0.068 | 2 | 0.642 |
GRK4 |
0.806 | 0.054 | -2 | 0.836 |
SKMLCK |
0.806 | -0.012 | -2 | 0.806 |
P38G |
0.806 | 0.070 | 1 | 0.466 |
TTBK2 |
0.806 | 0.038 | 2 | 0.694 |
RSK2 |
0.806 | -0.009 | -3 | 0.664 |
NEK9 |
0.806 | -0.007 | 2 | 0.842 |
MLK4 |
0.806 | 0.070 | 2 | 0.753 |
NDR1 |
0.806 | -0.042 | -3 | 0.729 |
NUAK2 |
0.806 | -0.026 | -3 | 0.727 |
YSK4 |
0.805 | 0.157 | 1 | 0.633 |
PRKD2 |
0.805 | -0.004 | -3 | 0.648 |
ULK1 |
0.804 | -0.085 | -3 | 0.720 |
MLK2 |
0.804 | -0.022 | 2 | 0.833 |
HIPK1 |
0.804 | 0.071 | 1 | 0.575 |
DNAPK |
0.804 | 0.103 | 1 | 0.648 |
CDK2 |
0.804 | 0.063 | 1 | 0.568 |
PKACG |
0.804 | 0.012 | -2 | 0.682 |
PKR |
0.804 | 0.097 | 1 | 0.631 |
DLK |
0.803 | -0.010 | 1 | 0.600 |
RSK3 |
0.803 | -0.018 | -3 | 0.661 |
ATM |
0.803 | -0.020 | 1 | 0.574 |
HUNK |
0.803 | -0.073 | 2 | 0.770 |
CAMLCK |
0.803 | -0.040 | -2 | 0.789 |
CDK7 |
0.802 | 0.014 | 1 | 0.552 |
CDK17 |
0.802 | 0.050 | 1 | 0.472 |
CLK4 |
0.802 | 0.047 | -3 | 0.669 |
P90RSK |
0.802 | -0.029 | -3 | 0.676 |
PKCZ |
0.802 | 0.034 | 2 | 0.795 |
P38A |
0.802 | 0.053 | 1 | 0.561 |
AURC |
0.802 | 0.039 | -2 | 0.606 |
CAMK2D |
0.801 | -0.030 | -3 | 0.721 |
CK1A2 |
0.801 | 0.234 | -3 | 0.684 |
DAPK2 |
0.801 | -0.064 | -3 | 0.755 |
ANKRD3 |
0.801 | 0.000 | 1 | 0.639 |
LATS1 |
0.801 | 0.046 | -3 | 0.752 |
CHAK1 |
0.801 | 0.037 | 2 | 0.777 |
IRE2 |
0.801 | 0.037 | 2 | 0.779 |
CLK1 |
0.801 | 0.058 | -3 | 0.628 |
P38B |
0.800 | 0.058 | 1 | 0.520 |
LATS2 |
0.800 | -0.045 | -5 | 0.746 |
PKCH |
0.800 | 0.054 | 2 | 0.758 |
WNK3 |
0.800 | -0.070 | 1 | 0.637 |
MASTL |
0.799 | -0.146 | -2 | 0.776 |
MAPKAPK3 |
0.799 | -0.057 | -3 | 0.661 |
ERK2 |
0.799 | 0.043 | 1 | 0.556 |
CDK9 |
0.799 | 0.032 | 1 | 0.549 |
NEK2 |
0.798 | 0.048 | 2 | 0.822 |
MST3 |
0.798 | 0.195 | 2 | 0.845 |
CDK10 |
0.797 | 0.096 | 1 | 0.534 |
PLK1 |
0.797 | -0.026 | -2 | 0.751 |
MAPKAPK2 |
0.797 | -0.043 | -3 | 0.630 |
ALK4 |
0.797 | -0.016 | -2 | 0.783 |
P70S6KB |
0.797 | -0.037 | -3 | 0.684 |
MARK4 |
0.797 | -0.072 | 4 | 0.770 |
TGFBR1 |
0.797 | -0.018 | -2 | 0.763 |
TLK2 |
0.796 | 0.028 | 1 | 0.609 |
RIPK1 |
0.796 | -0.093 | 1 | 0.596 |
CAMK2B |
0.796 | -0.021 | 2 | 0.778 |
TAO3 |
0.796 | 0.166 | 1 | 0.624 |
HIPK3 |
0.795 | 0.049 | 1 | 0.580 |
MEKK3 |
0.795 | 0.133 | 1 | 0.607 |
P38D |
0.795 | 0.062 | 1 | 0.484 |
PRP4 |
0.795 | 0.061 | -3 | 0.744 |
MEK1 |
0.795 | -0.005 | 2 | 0.836 |
AMPKA1 |
0.795 | -0.077 | -3 | 0.739 |
MSK2 |
0.794 | -0.031 | -3 | 0.663 |
ACVR2B |
0.794 | -0.006 | -2 | 0.752 |
PHKG1 |
0.794 | -0.018 | -3 | 0.722 |
MNK2 |
0.794 | -0.002 | -2 | 0.719 |
PAK1 |
0.794 | -0.023 | -2 | 0.722 |
RSK4 |
0.794 | 0.003 | -3 | 0.649 |
PKACB |
0.793 | 0.023 | -2 | 0.609 |
CDK16 |
0.793 | 0.057 | 1 | 0.486 |
ACVR2A |
0.793 | -0.012 | -2 | 0.737 |
AURA |
0.793 | 0.049 | -2 | 0.594 |
TNIK |
0.793 | 0.307 | 3 | 0.912 |
ALK2 |
0.793 | 0.003 | -2 | 0.784 |
MEKK2 |
0.792 | 0.132 | 2 | 0.815 |
CAMK2A |
0.792 | -0.031 | 2 | 0.793 |
SMG1 |
0.792 | -0.056 | 1 | 0.595 |
CDK14 |
0.792 | 0.047 | 1 | 0.547 |
DYRK1A |
0.792 | 0.024 | 1 | 0.596 |
GCK |
0.792 | 0.320 | 1 | 0.683 |
MNK1 |
0.792 | -0.002 | -2 | 0.732 |
KHS2 |
0.792 | 0.384 | 1 | 0.727 |
AKT2 |
0.792 | 0.028 | -3 | 0.588 |
MINK |
0.792 | 0.355 | 1 | 0.681 |
AURB |
0.792 | 0.030 | -2 | 0.603 |
VRK2 |
0.792 | -0.086 | 1 | 0.636 |
TSSK2 |
0.792 | -0.065 | -5 | 0.826 |
MEKK1 |
0.791 | 0.043 | 1 | 0.613 |
PAK3 |
0.791 | -0.040 | -2 | 0.716 |
NIM1 |
0.791 | -0.078 | 3 | 0.728 |
DYRK4 |
0.791 | 0.031 | 1 | 0.515 |
GRK2 |
0.791 | 0.000 | -2 | 0.720 |
PRKD3 |
0.791 | -0.025 | -3 | 0.625 |
ZAK |
0.791 | 0.048 | 1 | 0.585 |
TSSK1 |
0.790 | -0.050 | -3 | 0.754 |
PKCT |
0.789 | 0.049 | 2 | 0.765 |
TLK1 |
0.789 | 0.055 | -2 | 0.786 |
KHS1 |
0.789 | 0.373 | 1 | 0.714 |
CDK6 |
0.789 | 0.097 | 1 | 0.529 |
MPSK1 |
0.789 | 0.064 | 1 | 0.565 |
PERK |
0.789 | -0.021 | -2 | 0.804 |
HPK1 |
0.789 | 0.334 | 1 | 0.707 |
PRKX |
0.789 | 0.018 | -3 | 0.582 |
AMPKA2 |
0.789 | -0.077 | -3 | 0.704 |
DYRK1B |
0.788 | 0.021 | 1 | 0.530 |
SGK3 |
0.788 | 0.014 | -3 | 0.651 |
PKG2 |
0.788 | 0.009 | -2 | 0.606 |
MEK5 |
0.788 | 0.011 | 2 | 0.828 |
MST2 |
0.788 | 0.216 | 1 | 0.655 |
CAMK4 |
0.788 | -0.112 | -3 | 0.707 |
BMPR1A |
0.788 | 0.014 | 1 | 0.496 |
HGK |
0.788 | 0.260 | 3 | 0.898 |
PINK1 |
0.787 | -0.085 | 1 | 0.625 |
DYRK3 |
0.787 | 0.027 | 1 | 0.574 |
MSK1 |
0.787 | -0.008 | -3 | 0.657 |
JNK1 |
0.786 | 0.044 | 1 | 0.517 |
PLK4 |
0.786 | -0.006 | 2 | 0.618 |
PKCE |
0.785 | 0.080 | 2 | 0.760 |
HRI |
0.785 | -0.047 | -2 | 0.783 |
CDK4 |
0.785 | 0.077 | 1 | 0.526 |
PLK3 |
0.785 | -0.076 | 2 | 0.744 |
NEK5 |
0.785 | 0.001 | 1 | 0.612 |
PAK6 |
0.785 | 0.002 | -2 | 0.648 |
NUAK1 |
0.785 | -0.087 | -3 | 0.669 |
PKCI |
0.784 | 0.045 | 2 | 0.775 |
QIK |
0.784 | -0.098 | -3 | 0.710 |
GSK3A |
0.783 | 0.031 | 4 | 0.482 |
NEK11 |
0.783 | 0.095 | 1 | 0.640 |
EEF2K |
0.783 | 0.151 | 3 | 0.902 |
PAK2 |
0.783 | -0.052 | -2 | 0.715 |
QSK |
0.783 | -0.060 | 4 | 0.739 |
GRK3 |
0.783 | 0.029 | -2 | 0.697 |
MELK |
0.782 | -0.104 | -3 | 0.681 |
MYLK4 |
0.782 | -0.034 | -2 | 0.720 |
AKT1 |
0.782 | 0.032 | -3 | 0.600 |
TAO2 |
0.782 | 0.104 | 2 | 0.860 |
MAK |
0.782 | 0.076 | -2 | 0.720 |
PIM2 |
0.782 | -0.015 | -3 | 0.634 |
IRAK4 |
0.782 | -0.033 | 1 | 0.586 |
ERK7 |
0.781 | 0.027 | 2 | 0.566 |
WNK4 |
0.781 | -0.020 | -2 | 0.796 |
BRAF |
0.781 | -0.042 | -4 | 0.796 |
PHKG2 |
0.781 | 0.011 | -3 | 0.668 |
MST1 |
0.780 | 0.222 | 1 | 0.661 |
DRAK1 |
0.780 | -0.124 | 1 | 0.524 |
NEK8 |
0.779 | 0.001 | 2 | 0.826 |
GAK |
0.778 | 0.037 | 1 | 0.596 |
SIK |
0.778 | -0.077 | -3 | 0.649 |
CAMK1G |
0.778 | -0.078 | -3 | 0.653 |
GSK3B |
0.778 | 0.007 | 4 | 0.473 |
MAPKAPK5 |
0.777 | -0.115 | -3 | 0.630 |
NEK4 |
0.777 | 0.114 | 1 | 0.655 |
DCAMKL1 |
0.777 | -0.067 | -3 | 0.672 |
TAK1 |
0.777 | 0.197 | 1 | 0.652 |
CAMKK1 |
0.777 | -0.032 | -2 | 0.726 |
SNRK |
0.776 | -0.141 | 2 | 0.673 |
PKACA |
0.776 | 0.009 | -2 | 0.555 |
TTBK1 |
0.776 | -0.040 | 2 | 0.613 |
PDK1 |
0.776 | -0.002 | 1 | 0.620 |
CK2A2 |
0.776 | -0.006 | 1 | 0.464 |
SLK |
0.774 | 0.085 | -2 | 0.673 |
PASK |
0.774 | -0.050 | -3 | 0.768 |
CHK1 |
0.774 | -0.126 | -3 | 0.699 |
MAP3K15 |
0.774 | 0.061 | 1 | 0.587 |
LKB1 |
0.774 | -0.026 | -3 | 0.746 |
MARK3 |
0.773 | -0.082 | 4 | 0.689 |
BRSK1 |
0.773 | -0.112 | -3 | 0.680 |
SMMLCK |
0.773 | -0.054 | -3 | 0.705 |
LOK |
0.772 | 0.090 | -2 | 0.710 |
CK1A |
0.772 | 0.190 | -3 | 0.623 |
LRRK2 |
0.772 | 0.030 | 2 | 0.843 |
MOK |
0.771 | 0.034 | 1 | 0.559 |
MARK2 |
0.771 | -0.098 | 4 | 0.650 |
CAMKK2 |
0.771 | -0.065 | -2 | 0.721 |
BRSK2 |
0.771 | -0.134 | -3 | 0.692 |
MEKK6 |
0.770 | 0.029 | 1 | 0.587 |
PKN1 |
0.770 | -0.007 | -3 | 0.606 |
AKT3 |
0.769 | 0.023 | -3 | 0.539 |
OSR1 |
0.769 | 0.114 | 2 | 0.810 |
DCAMKL2 |
0.768 | -0.094 | -3 | 0.680 |
P70S6K |
0.767 | -0.052 | -3 | 0.598 |
CK2A1 |
0.767 | -0.009 | 1 | 0.451 |
YSK1 |
0.767 | 0.084 | 2 | 0.826 |
NEK1 |
0.767 | 0.018 | 1 | 0.610 |
PLK2 |
0.767 | -0.023 | -3 | 0.748 |
MARK1 |
0.767 | -0.110 | 4 | 0.715 |
SSTK |
0.767 | -0.067 | 4 | 0.730 |
PAK5 |
0.767 | -0.026 | -2 | 0.590 |
HASPIN |
0.766 | 0.074 | -1 | 0.720 |
SGK1 |
0.766 | 0.011 | -3 | 0.525 |
DAPK3 |
0.765 | -0.040 | -3 | 0.698 |
IRAK1 |
0.765 | -0.145 | -1 | 0.740 |
MYO3A |
0.764 | 0.192 | 1 | 0.664 |
PAK4 |
0.764 | -0.024 | -2 | 0.604 |
MYO3B |
0.764 | 0.138 | 2 | 0.844 |
ROCK2 |
0.763 | 0.030 | -3 | 0.680 |
STK33 |
0.763 | -0.063 | 2 | 0.604 |
MRCKB |
0.762 | 0.023 | -3 | 0.623 |
VRK1 |
0.762 | -0.091 | 2 | 0.826 |
CHK2 |
0.761 | -0.017 | -3 | 0.530 |
CAMK1D |
0.760 | -0.082 | -3 | 0.575 |
DAPK1 |
0.760 | -0.042 | -3 | 0.690 |
BUB1 |
0.759 | -0.011 | -5 | 0.785 |
TTK |
0.758 | 0.047 | -2 | 0.780 |
MRCKA |
0.758 | -0.001 | -3 | 0.641 |
CK1G3 |
0.758 | 0.224 | -3 | 0.582 |
TAO1 |
0.756 | 0.086 | 1 | 0.595 |
PBK |
0.755 | -0.054 | 1 | 0.533 |
MEK2 |
0.755 | -0.111 | 2 | 0.811 |
PDHK3_TYR |
0.755 | 0.082 | 4 | 0.880 |
YANK3 |
0.755 | 0.018 | 2 | 0.383 |
RIPK2 |
0.753 | -0.138 | 1 | 0.572 |
NEK3 |
0.752 | -0.054 | 1 | 0.578 |
ROCK1 |
0.751 | 0.024 | -3 | 0.644 |
ALPHAK3 |
0.751 | 0.002 | -1 | 0.760 |
DMPK1 |
0.750 | 0.002 | -3 | 0.643 |
SBK |
0.750 | -0.032 | -3 | 0.473 |
CAMK1A |
0.750 | -0.066 | -3 | 0.546 |
ASK1 |
0.749 | -0.006 | 1 | 0.580 |
PDHK4_TYR |
0.749 | 0.047 | 2 | 0.863 |
BMPR2_TYR |
0.748 | 0.070 | -1 | 0.885 |
MAP2K6_TYR |
0.747 | 0.034 | -1 | 0.880 |
MAP2K4_TYR |
0.746 | -0.012 | -1 | 0.872 |
TESK1_TYR |
0.745 | -0.047 | 3 | 0.845 |
PKG1 |
0.744 | -0.034 | -2 | 0.509 |
PDHK1_TYR |
0.743 | 0.002 | -1 | 0.880 |
PINK1_TYR |
0.742 | -0.056 | 1 | 0.606 |
MAP2K7_TYR |
0.742 | -0.078 | 2 | 0.848 |
BIKE |
0.742 | -0.055 | 1 | 0.509 |
PKMYT1_TYR |
0.742 | -0.065 | 3 | 0.808 |
LIMK2_TYR |
0.740 | -0.030 | -3 | 0.770 |
CRIK |
0.738 | -0.027 | -3 | 0.595 |
STLK3 |
0.738 | -0.021 | 1 | 0.579 |
CK1G2 |
0.738 | 0.180 | -3 | 0.655 |
TYK2 |
0.736 | 0.042 | 1 | 0.618 |
RET |
0.735 | -0.015 | 1 | 0.613 |
CSF1R |
0.734 | 0.016 | 3 | 0.744 |
MST1R |
0.734 | -0.022 | 3 | 0.766 |
ROS1 |
0.734 | 0.020 | 3 | 0.739 |
LIMK1_TYR |
0.733 | -0.122 | 2 | 0.855 |
EPHA6 |
0.733 | -0.016 | -1 | 0.859 |
JAK2 |
0.733 | 0.010 | 1 | 0.613 |
JAK3 |
0.731 | -0.022 | 1 | 0.563 |
FGR |
0.731 | -0.027 | 1 | 0.570 |
JAK1 |
0.731 | 0.093 | 1 | 0.598 |
NEK10_TYR |
0.730 | 0.041 | 1 | 0.578 |
LCK |
0.730 | 0.040 | -1 | 0.814 |
ABL2 |
0.729 | -0.022 | -1 | 0.772 |
AAK1 |
0.728 | -0.028 | 1 | 0.437 |
TNNI3K_TYR |
0.728 | 0.021 | 1 | 0.581 |
TYRO3 |
0.727 | -0.093 | 3 | 0.765 |
EPHB4 |
0.727 | -0.083 | -1 | 0.825 |
TXK |
0.727 | -0.018 | 1 | 0.525 |
BLK |
0.727 | 0.016 | -1 | 0.820 |
INSRR |
0.726 | -0.022 | 3 | 0.685 |
YES1 |
0.725 | -0.074 | -1 | 0.812 |
HCK |
0.725 | -0.034 | -1 | 0.809 |
YANK2 |
0.725 | 0.013 | 2 | 0.407 |
WEE1_TYR |
0.724 | 0.016 | -1 | 0.723 |
KIT |
0.724 | -0.027 | 3 | 0.737 |
ABL1 |
0.723 | -0.046 | -1 | 0.759 |
FLT3 |
0.723 | -0.025 | 3 | 0.772 |
KDR |
0.723 | -0.036 | 3 | 0.701 |
FYN |
0.721 | 0.018 | -1 | 0.803 |
FER |
0.720 | -0.135 | 1 | 0.582 |
MET |
0.720 | -0.031 | 3 | 0.719 |
DDR1 |
0.719 | -0.208 | 4 | 0.784 |
ITK |
0.719 | -0.088 | -1 | 0.776 |
PDGFRB |
0.719 | -0.124 | 3 | 0.760 |
EPHA4 |
0.718 | -0.095 | 2 | 0.735 |
TNK1 |
0.717 | -0.087 | 3 | 0.742 |
FLT1 |
0.717 | -0.036 | -1 | 0.831 |
FGFR2 |
0.717 | -0.127 | 3 | 0.718 |
SRMS |
0.717 | -0.123 | 1 | 0.565 |
TNK2 |
0.716 | -0.121 | 3 | 0.690 |
SYK |
0.716 | 0.081 | -1 | 0.790 |
ERBB2 |
0.714 | -0.049 | 1 | 0.564 |
PDGFRA |
0.714 | -0.123 | 3 | 0.768 |
FRK |
0.714 | -0.022 | -1 | 0.808 |
EPHB2 |
0.713 | -0.107 | -1 | 0.799 |
BMX |
0.713 | -0.065 | -1 | 0.688 |
EPHB1 |
0.712 | -0.153 | 1 | 0.559 |
EPHB3 |
0.711 | -0.141 | -1 | 0.808 |
FGFR1 |
0.711 | -0.149 | 3 | 0.693 |
LYN |
0.711 | -0.054 | 3 | 0.677 |
BTK |
0.711 | -0.118 | -1 | 0.725 |
TEC |
0.710 | -0.084 | -1 | 0.693 |
TEK |
0.709 | -0.166 | 3 | 0.678 |
EGFR |
0.708 | -0.050 | 1 | 0.468 |
PTK2 |
0.708 | 0.014 | -1 | 0.821 |
FGFR3 |
0.708 | -0.102 | 3 | 0.686 |
INSR |
0.708 | -0.102 | 3 | 0.675 |
MERTK |
0.708 | -0.136 | 3 | 0.703 |
ALK |
0.708 | -0.118 | 3 | 0.662 |
SRC |
0.707 | -0.056 | -1 | 0.782 |
NTRK1 |
0.707 | -0.159 | -1 | 0.802 |
PTK6 |
0.707 | -0.162 | -1 | 0.687 |
FLT4 |
0.706 | -0.131 | 3 | 0.690 |
AXL |
0.706 | -0.169 | 3 | 0.697 |
MATK |
0.705 | -0.075 | -1 | 0.690 |
EPHA7 |
0.704 | -0.123 | 2 | 0.739 |
EPHA3 |
0.704 | -0.133 | 2 | 0.712 |
LTK |
0.703 | -0.154 | 3 | 0.680 |
NTRK3 |
0.703 | -0.138 | -1 | 0.751 |
NTRK2 |
0.702 | -0.177 | 3 | 0.687 |
EPHA1 |
0.702 | -0.132 | 3 | 0.705 |
EPHA8 |
0.701 | -0.091 | -1 | 0.797 |
FGFR4 |
0.701 | -0.059 | -1 | 0.739 |
ERBB4 |
0.700 | -0.008 | 1 | 0.477 |
DDR2 |
0.700 | -0.140 | 3 | 0.664 |
EPHA5 |
0.699 | -0.108 | 2 | 0.718 |
ZAP70 |
0.699 | 0.050 | -1 | 0.708 |
CSK |
0.697 | -0.120 | 2 | 0.748 |
MUSK |
0.695 | -0.109 | 1 | 0.458 |
PTK2B |
0.694 | -0.160 | -1 | 0.731 |
IGF1R |
0.693 | -0.100 | 3 | 0.602 |
EPHA2 |
0.687 | -0.118 | -1 | 0.765 |
FES |
0.670 | -0.158 | -1 | 0.658 |