Motif 844 (n=219)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0U1RQV5 | None | S27 | ochoa | Eukaryotic translation initiation factor 6 | None |
| A0MZ66 | SHTN1 | S464 | ochoa | Shootin-1 (Shootin1) | Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Also plays a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons. {ECO:0000250|UniProtKB:A0MZ67, ECO:0000250|UniProtKB:Q8K2Q9}. |
| H0YHG0 | None | S428 | ochoa | DnaJ homolog subfamily C member 14 (Nuclear protein Hcc-1) (SAP domain-containing ribonucleoprotein) | Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. Associates with DDX39B, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export. {ECO:0000256|ARBA:ARBA00054093}.; FUNCTION: Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface. {ECO:0000256|ARBA:ARBA00055510}. |
| O00522 | KRIT1 | S22 | ochoa | Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein) | Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity (By similarity). Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Promotes AKT phosphorylation in a NOTCH-dependent and independent manner, and inhibits ERK1/2 phosphorylation indirectly through activation of the DELTA-NOTCH cascade. Acts in concert with CDH5 to establish and maintain correct endothelial cell polarity and vascular lumen and these effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction, and cell junction stabilization. Plays a role in integrin signaling via its interaction with ITGB1BP1; this prevents the interaction between ITGB1 and ITGB1BP1. Microtubule-associated protein that binds to phosphatidylinositol 4,5-bisphosphate (PIP2)-containing membranes in a GTP-bound RAP1-dependent manner. Plays an important role in the maintenance of the intracellular reactive oxygen species (ROS) homeostasis to prevent oxidative cellular damage. Regulates the homeostasis of intracellular ROS through an antioxidant pathway involving FOXO1 and SOD2. Facilitates the down-regulation of cyclin-D1 (CCND1) levels required for cell transition from proliferative growth to quiescence by preventing the accumulation of intracellular ROS through the modulation of FOXO1 and SOD2 levels. May play a role in the regulation of macroautophagy through the down-regulation of the mTOR pathway (PubMed:26417067). {ECO:0000250|UniProtKB:Q6S5J6, ECO:0000269|PubMed:11741838, ECO:0000269|PubMed:17916086, ECO:0000269|PubMed:20332120, ECO:0000269|PubMed:20616044, ECO:0000269|PubMed:20668652, ECO:0000269|PubMed:21633110, ECO:0000269|PubMed:23317506, ECO:0000269|PubMed:26417067}. |
| O00533 | CHL1 | S1147 | ochoa | Neural cell adhesion molecule L1-like protein (Close homolog of L1) [Cleaved into: Processed neural cell adhesion molecule L1-like protein] | Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane (By similarity). {ECO:0000250}. |
| O14639 | ABLIM1 | S632 | ochoa | Actin-binding LIM protein 1 (abLIM-1) (Actin-binding LIM protein family member 1) (Actin-binding double zinc finger protein) (LIMAB1) (Limatin) | May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance. {ECO:0000250, ECO:0000269|PubMed:9245787}. |
| O14646 | CHD1 | S1622 | ochoa | Chromodomain-helicase-DNA-binding protein 1 (CHD-1) (EC 3.6.4.-) (ATP-dependent helicase CHD1) | ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3 (PubMed:18042460, PubMed:28866611). Required for maintaining open chromatin and pluripotency in embryonic stem cells (By similarity). {ECO:0000250|UniProtKB:P40201, ECO:0000269|PubMed:18042460, ECO:0000269|PubMed:28866611}. |
| O15013 | ARHGEF10 | S1232 | ochoa | Rho guanine nucleotide exchange factor 10 | May play a role in developmental myelination of peripheral nerves. {ECO:0000269|PubMed:14508709}. |
| O43164 | PJA2 | S196 | ochoa | E3 ubiquitin-protein ligase Praja-2 (Praja2) (EC 2.3.2.27) (RING finger protein 131) (RING-type E3 ubiquitin transferase Praja-2) | Has E2-dependent E3 ubiquitin-protein ligase activity (PubMed:12036302, PubMed:21423175). Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes (PubMed:21423175). Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype (PubMed:28471450). Plays a role in ciliogenesis by ubiquitinating OFD1 (PubMed:33934390). {ECO:0000269|PubMed:12036302, ECO:0000269|PubMed:21423175, ECO:0000269|PubMed:28471450, ECO:0000269|PubMed:33934390}. |
| O43166 | SIPA1L1 | S258 | ochoa | Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) | Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}. |
| O43166 | SIPA1L1 | S1650 | ochoa | Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) | Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}. |
| O43293 | DAPK3 | S312 | ochoa | Death-associated protein kinase 3 (DAP kinase 3) (EC 2.7.11.1) (DAP-like kinase) (Dlk) (MYPT1 kinase) (Zipper-interacting protein kinase) (ZIP-kinase) | Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation and actin cytoskeleton reorganization. Involved in the regulation of smooth muscle contraction. Regulates both type I (caspase-dependent) apoptotic and type II (caspase-independent) autophagic cell deaths signal, depending on the cellular setting. Involved in regulation of starvation-induced autophagy. Regulates myosin phosphorylation in both smooth muscle and non-muscle cells. In smooth muscle, regulates myosin either directly by phosphorylating MYL12B and MYL9 or through inhibition of smooth muscle myosin phosphatase (SMPP1M) via phosphorylation of PPP1R12A; the inhibition of SMPP1M functions to enhance muscle responsiveness to Ca(2+) and promote a contractile state. Phosphorylates MYL12B in non-muscle cells leading to reorganization of actin cytoskeleton. Isoform 2 can phosphorylate myosin, PPP1R12A and MYL12B. Overexpression leads to condensation of actin stress fibers into thick bundles. Involved in actin filament focal adhesion dynamics. The function in both reorganization of actin cytoskeleton and focal adhesion dissolution is modulated by RhoD. Positively regulates canonical Wnt/beta-catenin signaling through interaction with NLK and TCF7L2. Phosphorylates RPL13A on 'Ser-77' upon interferon-gamma activation which is causing RPL13A release from the ribosome, RPL13A association with the GAIT complex and its subsequent involvement in transcript-selective translation inhibition. Enhances transcription from AR-responsive promoters in a hormone- and kinase-dependent manner. Involved in regulation of cell cycle progression and cell proliferation. May be a tumor suppressor. {ECO:0000269|PubMed:10356987, ECO:0000269|PubMed:11384979, ECO:0000269|PubMed:11781833, ECO:0000269|PubMed:12917339, ECO:0000269|PubMed:15096528, ECO:0000269|PubMed:15367680, ECO:0000269|PubMed:16219639, ECO:0000269|PubMed:17126281, ECO:0000269|PubMed:17158456, ECO:0000269|PubMed:18084323, ECO:0000269|PubMed:18995835, ECO:0000269|PubMed:21169990, ECO:0000269|PubMed:21408167, ECO:0000269|PubMed:21454679, ECO:0000269|PubMed:21487036, ECO:0000269|PubMed:23454120, ECO:0000269|PubMed:38009294}. |
| O60343 | TBC1D4 | S486 | ochoa | TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160) | May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake. {ECO:0000269|PubMed:15971998, ECO:0000269|PubMed:18771725, ECO:0000269|PubMed:22908308}. |
| O75037 | KIF21B | S1167 | ochoa | Kinesin-like protein KIF21B | Plus-end directed microtubule-dependent motor protein which displays processive activity. Is involved in regulation of microtubule dynamics, synapse function and neuronal morphology, including dendritic tree branching and spine formation. Plays a role in lerning and memory. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptor to cell surface. {ECO:0000250|UniProtKB:Q9QXL1}. |
| O75044 | SRGAP2 | S900 | ochoa | SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2) (Rho GTPase-activating protein 34) | Postsynaptic RAC1 GTPase activating protein (GAP) that plays a key role in neuronal morphogenesis and migration mainly during development of the cerebral cortex (PubMed:20810653, PubMed:27373832, PubMed:28333212). Regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons (PubMed:22559944, PubMed:27373832). SRGAP2/SRGAP2A limits excitatory and inhibitory synapse density through its RAC1-specific GTPase activating activity, while it promotes maturation of both excitatory and inhibitory synapses through its ability to bind to the postsynaptic scaffolding protein HOMER1 at excitatory synapses, and the postsynaptic protein GPHN at inhibitory synapses (By similarity). Mechanistically, acts by binding and deforming membranes, thereby regulating actin dynamics to regulate cell migration and differentiation (PubMed:27373832). Promotes cell repulsion and contact inhibition of locomotion: localizes to protrusions with curved edges and controls the duration of RAC1 activity in contact protrusions (By similarity). In non-neuronal cells, may also play a role in cell migration by regulating the formation of lamellipodia and filopodia (PubMed:20810653, PubMed:21148482). {ECO:0000250|UniProtKB:Q91Z67, ECO:0000269|PubMed:20810653, ECO:0000269|PubMed:21148482, ECO:0000269|PubMed:22559944, ECO:0000269|PubMed:27373832, ECO:0000269|PubMed:28333212}. |
| O75052 | NOS1AP | S374 | ochoa | Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C-terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein) | Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 (By similarity). In kidney podocytes, plays a role in podosomes and filopodia formation through CDC42 activation (PubMed:33523862). {ECO:0000250|UniProtKB:O54960, ECO:0000269|PubMed:33523862}. |
| O75064 | DENND4B | S963 | ochoa | DENN domain-containing protein 4B | Guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}. |
| O75143 | ATG13 | S478 | ochoa | Autophagy-related protein 13 | Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation. {ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:19211835, ECO:0000269|PubMed:19225151, ECO:0000269|PubMed:19287211, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:21855797}. |
| O75643 | SNRNP200 | S42 | ochoa | U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.4.13) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog) (U5 snRNP-specific 200 kDa protein) (U5-200KD) | Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome (PubMed:35241646). Plays a role in pre-mRNA splicing as a core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:28502770, PubMed:28781166, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30315277, PubMed:30705154, PubMed:30728453). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. {ECO:0000269|PubMed:16723661, ECO:0000269|PubMed:23045696, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:30728453, ECO:0000269|PubMed:35241646, ECO:0000269|PubMed:8670905, ECO:0000269|PubMed:9539711, ECO:0000305|PubMed:33509932}. |
| O75688 | PPM1B | S195 | ochoa|psp | Protein phosphatase 1B (EC 3.1.3.16) (Protein phosphatase 2C isoform beta) (PP2C-beta) | Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. {ECO:0000269|PubMed:18930133, ECO:0000269|PubMed:22750291}. |
| O75762 | TRPA1 | S317 | psp | Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Transformation-sensitive protein p120) (p120) (Wasabi receptor) | Ligand-activated Ca(2+)-permeable, nonselective cation channel involved in pain detection and possibly also in cold perception, oxygen concentration perception, cough, itch, and inner ear function (PubMed:17259981, PubMed:21195050, PubMed:21873995, PubMed:23199233, PubMed:25389312, PubMed:33152265). Has a relatively high Ca(2+) selectivity, with a preference for divalent over monovalent cations (Ca(2+) > Ba(2+) > Mg(2+) > NH4(+) > Li(+) > K(+)), the influx of cation into the cytoplasm leads to membrane depolarization (PubMed:19202543, PubMed:21195050). Has a central role in the pain response to endogenous inflammatory mediators, such as bradykinin and to a diverse array of irritants. Activated by a large variety of structurally unrelated electrophilic and non-electrophilic chemical compounds, such as allylthiocyanate (AITC) from mustard oil or wasabi, cinnamaldehyde, diallyl disulfide (DADS) from garlic, and acrolein, an environmental irritant (PubMed:20547126, PubMed:25389312, PubMed:27241698, PubMed:30878828). Electrophilic ligands activate TRPA1 by interacting with critical N-terminal Cys residues in a covalent manner (PubMed:17164327, PubMed:27241698, PubMed:31866091, PubMed:32641835). Non-electrophile agonists bind at distinct sites in the transmembrane domain to promote channel activation (PubMed:33152265). Also acts as an ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana (PubMed:25389312). May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds (By similarity). {ECO:0000250|UniProtKB:Q8BLA8, ECO:0000269|PubMed:17164327, ECO:0000269|PubMed:17259981, ECO:0000269|PubMed:19202543, ECO:0000269|PubMed:20547126, ECO:0000269|PubMed:21195050, ECO:0000269|PubMed:21873995, ECO:0000269|PubMed:23199233, ECO:0000269|PubMed:25389312, ECO:0000269|PubMed:27241698, ECO:0000269|PubMed:30878828, ECO:0000269|PubMed:31866091, ECO:0000269|PubMed:32641835, ECO:0000269|PubMed:33152265}. |
| O75962 | TRIO | S523 | ochoa | Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein) | Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed:22155786, PubMed:27418539, PubMed:8643598). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed:10341202, PubMed:22155786). Plays a key role in the regulation of neurite outgrowth and lamellipodia formation (PubMed:32109419). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (By similarity). {ECO:0000250|UniProtKB:F1M0Z1, ECO:0000269|PubMed:10341202, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:27418539, ECO:0000269|PubMed:32109419, ECO:0000269|PubMed:8643598}. |
| O94759 | TRPM2 | S603 | ochoa | Transient receptor potential cation channel subfamily M member 2 (Estrogen-responsive element-associated gene 1 protein) (Long transient receptor potential channel 2) (LTrpC-2) (LTrpC2) (Transient receptor potential channel 7) (TrpC7) (Transient receptor potential melastatin 2) | [Isoform 1]: Nonselective, voltage-independent cation channel that mediates Na(+) and Ca(2+) influx, leading to increased cytoplasmic Ca(2+) levels (PubMed:11385575, PubMed:11509734, PubMed:11804595, PubMed:12594222, PubMed:15561722, PubMed:16601673, PubMed:19171771, PubMed:20660597, PubMed:25620041, PubMed:27068538, PubMed:27383051, PubMed:28775320, PubMed:29745897, PubMed:30467180, PubMed:31513012, PubMed:34788616). Functions as a ligand-gated ion channel, gated by intracellular adenosine diphosphate ribose (ADP-ribose), Ca(2+), warm temperature, and oxidative stress (PubMed:19171771, PubMed:25620041, PubMed:28775320, PubMed:30467180). The precise physiological activators are under debate; the true, physiological activators may be ADP-ribose and ADP-ribose-2'-phosphate (PubMed:20650899, PubMed:25918360). Binding of ADP-ribose to the cytoplasmic Nudix domain causes a conformation change; the channel is primed but still requires Ca(2+) binding to trigger channel opening (PubMed:19171771, PubMed:25620041, PubMed:28775320, PubMed:29745897, PubMed:30467180). Extracellular Ca(2+) passes through the channel and increases channel activity (PubMed:19171771). Contributes to Ca(2+) release from intracellular stores in response to ADP-ribose (PubMed:19454650). Plays a role in numerous processes that involve signaling via intracellular Ca(2+) levels (Probable). Besides, mediates the release of lysosomal Zn(2+) stores in response to reactive oxygen species, leading to increased cytosolic Zn(2+) levels (PubMed:25562606, PubMed:27068538). Plays a role in mediating behavorial and physiological responses to moderate heat and thereby contributes to body temperature homeostasis. Plays a role in insulin secretion, a process that requires increased cytoplasmic Ca(2+) levels (By similarity). Required for normal IFNG and cytokine secretion and normal innate immune immunity in response to bacterial infection. Required for normal phagocytosis and cytokine release by macrophages exposed to zymosan (in vitro) (PubMed:22493272). Plays a role in dendritic cell differentiation and maturation, and in dendritic cell chemotaxis via its role in regulating cytoplasmic Ca(2+) levels (By similarity). Plays a role in the regulation of the reorganization of the actin cytoskeleton and filopodia formation in response to reactive oxygen species via its role in increasing cytoplasmic Ca(2+) and Zn(2+) levels (PubMed:27068538). Confers susceptibility to cell death following oxidative stress (PubMed:12594222, PubMed:25562606). {ECO:0000250|UniProtKB:Q91YD4, ECO:0000269|PubMed:11385575, ECO:0000269|PubMed:11509734, ECO:0000269|PubMed:11804595, ECO:0000269|PubMed:11960981, ECO:0000269|PubMed:12594222, ECO:0000269|PubMed:15561722, ECO:0000269|PubMed:16601673, ECO:0000269|PubMed:19171771, ECO:0000269|PubMed:19454650, ECO:0000269|PubMed:20650899, ECO:0000269|PubMed:20660597, ECO:0000269|PubMed:22493272, ECO:0000269|PubMed:25562606, ECO:0000269|PubMed:25620041, ECO:0000269|PubMed:25918360, ECO:0000269|PubMed:27068538, ECO:0000269|PubMed:27383051, ECO:0000269|PubMed:28775320, ECO:0000269|PubMed:29745897, ECO:0000269|PubMed:30467180, ECO:0000269|PubMed:31513012, ECO:0000269|PubMed:34788616}.; FUNCTION: [Isoform 2]: Lacks cation channel activity. Does not mediate cation transport in response to oxidative stress or ADP-ribose. {ECO:0000269|PubMed:11960981}.; FUNCTION: [Isoform 3]: Lacks cation channel activity and negatively regulates the channel activity of isoform 1. Negatively regulates susceptibility to cell death in reposponse to oxidative stress. {ECO:0000269|PubMed:12594222}. |
| O94915 | FRYL | S221 | ochoa | Protein furry homolog-like (ALL1-fused gene from chromosome 4p12 protein) | Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching (By similarity). May function as a transcriptional activator. {ECO:0000250, ECO:0000269|PubMed:16061630}. |
| O94929 | ABLIM3 | S163 | ochoa | Actin-binding LIM protein 3 (abLIM-3) (Actin-binding LIM protein family member 3) | May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity. {ECO:0000269|PubMed:17194709}. |
| O95210 | STBD1 | S188 | ochoa | Starch-binding domain-containing protein 1 (Genethonin-1) (Glycophagy cargo receptor STBD1) | Acts as a cargo receptor for glycogen. Delivers its cargo to an autophagic pathway called glycophagy, resulting in the transport of glycogen to lysosomes. {ECO:0000269|PubMed:20810658, ECO:0000269|PubMed:21893048, ECO:0000269|PubMed:24837458}. |
| O95490 | ADGRL2 | S1370 | ochoa | Adhesion G protein-coupled receptor L2 (Calcium-independent alpha-latrotoxin receptor 2) (CIRL-2) (Latrophilin homolog 1) (Latrophilin-2) (Lectomedin-1) | Orphan adhesion G-protein coupled receptor (aGPCR), which mediates synapse specificity (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (By similarity). Following G-protein coupled receptor activation, associates with cell adhesion molecules that are expressed at the surface of adjacent cells to direct synapse specificity. Specifically mediates the establishment of perforant-path synapses on CA1-region pyramidal neurons in the hippocampus. Localizes to postsynaptic spines in excitatory synapses in the S.lacunosum-moleculare and interacts with presynaptic cell adhesion molecules, such as teneurins, promoting synapse formation (By similarity). {ECO:0000250|UniProtKB:Q80TS3, ECO:0000250|UniProtKB:Q8JZZ7}. |
| P02686 | MBP | S205 | ochoa | Myelin basic protein (MBP) (Myelin A1 protein) (Myelin membrane encephalitogenic protein) | The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. {ECO:0000269|PubMed:8544862}. |
| P06733 | ENO1 | S115 | psp | Alpha-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (C-myc promoter-binding protein) (Enolase 1) (MBP-1) (MPB-1) (Non-neural enolase) (NNE) (Phosphopyruvate hydratase) (Plasminogen-binding protein) | Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (PubMed:1369209, PubMed:29775581). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses (PubMed:10802057, PubMed:12666133, PubMed:2005901, PubMed:29775581). May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (PubMed:12666133). Stimulates immunoglobulin production (PubMed:1369209). {ECO:0000269|PubMed:10802057, ECO:0000269|PubMed:12666133, ECO:0000269|PubMed:1369209, ECO:0000269|PubMed:2005901, ECO:0000269|PubMed:29775581}.; FUNCTION: [Isoform MBP-1]: Binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor. {ECO:0000269|PubMed:10082554}. |
| P07900 | HSP90AA1 | S63 | ochoa | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}. |
| P08238 | HSP90AB1 | S58 | ochoa | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}. |
| P10412 | H1-4 | S58 | ochoa | Histone H1.4 (Histone H1b) (Histone H1s-4) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P12270 | TPR | S632 | ochoa | Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:11952838, PubMed:22253824). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:21613532, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:9864356}. |
| P12931 | SRC | S493 | psp | Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src) | Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors (PubMed:34234773). Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates such as AFAP1. Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1 and to localize to actin filaments. Cytoskeletal reorganization is also controlled through the phosphorylation of cortactin (CTTN) (Probable). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN) (PubMed:21411625). In addition to phosphorylating focal adhesion proteins, SRC is also active at the sites of cell-cell contact adherens junctions and phosphorylates substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1), and plakoglobin (JUP). Another type of cell-cell junction, the gap junction, is also a target for SRC, which phosphorylates connexin-43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing and phosphorylates RNA-binding proteins such as KHDRBS1 (Probable). Phosphorylates PKP3 at 'Tyr-195' in response to reactive oxygen species, which may cause the release of PKP3 from desmosome cell junctions into the cytoplasm (PubMed:25501895). Also plays a role in PDGF-mediated tyrosine phosphorylation of both STAT1 and STAT3, leading to increased DNA binding activity of these transcription factors (By similarity). Involved in the RAS pathway through phosphorylation of RASA1 and RASGRF1 (PubMed:11389730). Plays a role in EGF-mediated calcium-activated chloride channel activation (PubMed:18586953). Required for epidermal growth factor receptor (EGFR) internalization through phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr-1477'. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization through phosphorylation and activation of GRK2, leading to beta-arrestin phosphorylation and internalization. Has a critical role in the stimulation of the CDK20/MAPK3 mitogen-activated protein kinase cascade by epidermal growth factor (Probable). Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus (PubMed:7853507). Plays an important role in osteoclastic bone resorption in conjunction with PTK2B/PYK2. Both the formation of a SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for this function. Recruited to activated integrins by PTK2B/PYK2, thereby phosphorylating CBL, which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:14585963, PubMed:8755529). Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase (PubMed:12615910). Phosphorylates DDR2 on tyrosine residues, thereby promoting its subsequent autophosphorylation (PubMed:16186108). Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731' (PubMed:20100835, PubMed:21309750). Enhances RIGI-elicited antiviral signaling (PubMed:19419966). Phosphorylates PDPK1 at 'Tyr-9', 'Tyr-373' and 'Tyr-376' (PubMed:14585963). Phosphorylates BCAR1 at 'Tyr-128' (PubMed:22710723). Phosphorylates CBLC at multiple tyrosine residues, phosphorylation at 'Tyr-341' activates CBLC E3 activity (PubMed:20525694). Phosphorylates synaptic vesicle protein synaptophysin (SYP) (By similarity). Involved in anchorage-independent cell growth (PubMed:19307596). Required for podosome formation (By similarity). Mediates IL6 signaling by activating YAP1-NOTCH pathway to induce inflammation-induced epithelial regeneration (PubMed:25731159). Phosphorylates OTUB1, promoting deubiquitination of RPTOR (PubMed:35927303). Phosphorylates caspase CASP8 at 'Tyr-380' which negatively regulates CASP8 processing and activation, down-regulating CASP8 proapoptotic function (PubMed:16619028). {ECO:0000250|UniProtKB:P05480, ECO:0000250|UniProtKB:Q9WUD9, ECO:0000269|PubMed:11389730, ECO:0000269|PubMed:12615910, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:16186108, ECO:0000269|PubMed:16619028, ECO:0000269|PubMed:18586953, ECO:0000269|PubMed:19307596, ECO:0000269|PubMed:19419966, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:20525694, ECO:0000269|PubMed:21309750, ECO:0000269|PubMed:21411625, ECO:0000269|PubMed:22710723, ECO:0000269|PubMed:25501895, ECO:0000269|PubMed:25731159, ECO:0000269|PubMed:34234773, ECO:0000269|PubMed:35927303, ECO:0000269|PubMed:7853507, ECO:0000269|PubMed:8755529, ECO:0000269|PubMed:8759729, ECO:0000305|PubMed:11964124, ECO:0000305|PubMed:8672527, ECO:0000305|PubMed:9442882}.; FUNCTION: [Isoform 1]: Non-receptor protein tyrosine kinase which phosphorylates synaptophysin with high affinity. {ECO:0000250|UniProtKB:Q9WUD9}.; FUNCTION: [Isoform 2]: Non-receptor protein tyrosine kinase which shows higher basal kinase activity than isoform 1, possibly due to weakened intramolecular interactions which enhance autophosphorylation of Tyr-419 and subsequent activation (By similarity). The SH3 domain shows reduced affinity with the linker sequence between the SH2 and kinase domains which may account for the increased basal activity (By similarity). Displays altered substrate specificity compared to isoform 1, showing weak affinity for synaptophysin and for peptide substrates containing class I or class II SH3 domain-binding motifs (By similarity). Plays a role in L1CAM-mediated neurite elongation, possibly by acting downstream of L1CAM to drive cytoskeletal rearrangements involved in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q9WUD9}.; FUNCTION: [Isoform 3]: Non-receptor protein tyrosine kinase which shows higher basal kinase activity than isoform 1, possibly due to weakened intramolecular interactions which enhance autophosphorylation of Tyr-419 and subsequent activation (By similarity). The SH3 domain shows reduced affinity with the linker sequence between the SH2 and kinase domains which may account for the increased basal activity (By similarity). Displays altered substrate specificity compared to isoform 1, showing weak affinity for synaptophysin and for peptide substrates containing class I or class II SH3 domain-binding motifs (By similarity). Plays a role in neurite elongation (By similarity). {ECO:0000250|UniProtKB:Q9WUD9}. |
| P13796 | LCP1 | S257 | ochoa | Plastin-2 (L-plastin) (LC64P) (Lymphocyte cytosolic protein 1) (LCP-1) | Actin-binding protein (PubMed:16636079, PubMed:17294403, PubMed:28493397). Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28 (PubMed:17294403). Modulates the cell surface expression of IL2RA/CD25 and CD69 (PubMed:17294403). {ECO:0000269|PubMed:16636079, ECO:0000269|PubMed:17294403, ECO:0000269|PubMed:28493397}. |
| P14859 | POU2F1 | S361 | ochoa | POU domain, class 2, transcription factor 1 (NF-A1) (Octamer-binding protein 1) (Oct-1) (Octamer-binding transcription factor 1) (OTF-1) | Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR. {ECO:0000269|PubMed:10480874, ECO:0000269|PubMed:1684878, ECO:0000269|PubMed:7859290}.; FUNCTION: (Microbial infection) In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000305|PubMed:12826401}. |
| P15498 | VAV1 | S756 | ochoa | Proto-oncogene vav | Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation. |
| P15822 | HIVEP1 | S1141 | ochoa | Zinc finger protein 40 (Cirhin interaction protein) (CIRIP) (Gate keeper of apoptosis-activating protein) (GAAP) (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis. |
| P16144 | ITGB4 | S1457 | ochoa | Integrin beta-4 (GP150) (CD antigen CD104) | Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:28873464}. |
| P16401 | H1-5 | S61 | ochoa | Histone H1.5 (Histone H1a) (Histone H1b) (Histone H1s-3) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P16402 | H1-3 | S59 | ochoa | Histone H1.3 (Histone H1c) (Histone H1s-2) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P16403 | H1-2 | S58 | ochoa | Histone H1.2 (Histone H1c) (Histone H1d) (Histone H1s-1) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P17600 | SYN1 | S681 | ochoa | Synapsin-1 (Brain protein 4.1) (Synapsin I) | Neuronal phosphoprotein that coats synaptic vesicles, and binds to the cytoskeleton. Acts as a regulator of synaptic vesicles trafficking, involved in the control of neurotransmitter release at the pre-synaptic terminal (PubMed:21441247, PubMed:23406870). Also involved in the regulation of axon outgrowth and synaptogenesis (By similarity). The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level (By similarity). {ECO:0000250|UniProtKB:O88935, ECO:0000250|UniProtKB:P09951, ECO:0000269|PubMed:21441247, ECO:0000269|PubMed:23406870}. |
| P19525 | EIF2AK2 | S242 | psp | Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2A protein kinase 2) (Interferon-inducible RNA-dependent protein kinase) (P1/eIF-2A protein kinase) (Protein kinase RNA-activated) (PKR) (Protein kinase R) (Tyrosine-protein kinase EIF2AK2) (EC 2.7.10.2) (p68 kinase) | IFN-induced dsRNA-dependent serine/threonine-protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) and plays a key role in the innate immune response to viral infection (PubMed:18835251, PubMed:19189853, PubMed:19507191, PubMed:21072047, PubMed:21123651, PubMed:22381929, PubMed:22948139, PubMed:23229543). Inhibits viral replication via the integrated stress response (ISR): EIF2S1/eIF-2-alpha phosphorylation in response to viral infection converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, resulting to a shutdown of cellular and viral protein synthesis, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4 (PubMed:19189853, PubMed:21123651, PubMed:22948139, PubMed:23229543). Exerts its antiviral activity on a wide range of DNA and RNA viruses including hepatitis C virus (HCV), hepatitis B virus (HBV), measles virus (MV) and herpes simplex virus 1 (HHV-1) (PubMed:11836380, PubMed:19189853, PubMed:19840259, PubMed:20171114, PubMed:21710204, PubMed:23115276, PubMed:23399035). Also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation: phosphorylates other substrates including p53/TP53, PPP2R5A, DHX9, ILF3, IRS1 and the HHV-1 viral protein US11 (PubMed:11836380, PubMed:19229320, PubMed:22214662). In addition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity and phosphorylates CDK1 at 'Tyr-4' upon DNA damage, facilitating its ubiquitination and proteasomal degradation (PubMed:20395957). Either as an adapter protein and/or via its kinase activity, can regulate various signaling pathways (p38 MAP kinase, NF-kappa-B and insulin signaling pathways) and transcription factors (JUN, STAT1, STAT3, IRF1, ATF3) involved in the expression of genes encoding pro-inflammatory cytokines and IFNs (PubMed:22948139, PubMed:23084476, PubMed:23372823). Activates the NF-kappa-B pathway via interaction with IKBKB and TRAF family of proteins and activates the p38 MAP kinase pathway via interaction with MAP2K6 (PubMed:10848580, PubMed:15121867, PubMed:15229216). Can act as both a positive and negative regulator of the insulin signaling pathway (ISP) (PubMed:20685959). Negatively regulates ISP by inducing the inhibitory phosphorylation of insulin receptor substrate 1 (IRS1) at 'Ser-312' and positively regulates ISP via phosphorylation of PPP2R5A which activates FOXO1, which in turn up-regulates the expression of insulin receptor substrate 2 (IRS2) (PubMed:20685959). Can regulate NLRP3 inflammasome assembly and the activation of NLRP3, NLRP1, AIM2 and NLRC4 inflammasomes (PubMed:22801494). Plays a role in the regulation of the cytoskeleton by binding to gelsolin (GSN), sequestering the protein in an inactive conformation away from actin (By similarity). {ECO:0000250|UniProtKB:Q03963, ECO:0000269|PubMed:10848580, ECO:0000269|PubMed:11836380, ECO:0000269|PubMed:15121867, ECO:0000269|PubMed:15229216, ECO:0000269|PubMed:18835251, ECO:0000269|PubMed:19189853, ECO:0000269|PubMed:19229320, ECO:0000269|PubMed:19507191, ECO:0000269|PubMed:19840259, ECO:0000269|PubMed:20171114, ECO:0000269|PubMed:20395957, ECO:0000269|PubMed:20685959, ECO:0000269|PubMed:21072047, ECO:0000269|PubMed:21123651, ECO:0000269|PubMed:21710204, ECO:0000269|PubMed:22214662, ECO:0000269|PubMed:22381929, ECO:0000269|PubMed:22801494, ECO:0000269|PubMed:22948139, ECO:0000269|PubMed:23084476, ECO:0000269|PubMed:23115276, ECO:0000269|PubMed:23229543, ECO:0000269|PubMed:23372823, ECO:0000269|PubMed:23399035, ECO:0000269|PubMed:32197074}. |
| P20290 | BTF3 | S158 | ochoa | Transcription factor BTF3 (Nascent polypeptide-associated complex subunit beta) (NAC-beta) (RNA polymerase B transcription factor 3) | When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription. {ECO:0000269|PubMed:10982809}. |
| P20810 | CAST | S527 | ochoa | Calpastatin (Calpain inhibitor) (Sperm BS-17 component) | Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. |
| P21730 | C5AR1 | S314 | psp | C5a anaphylatoxin chemotactic receptor 1 (C5a anaphylatoxin chemotactic receptor) (C5a-R) (C5aR) (CD antigen CD88) | Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:10636859, PubMed:15153520, PubMed:1847994, PubMed:29300009, PubMed:7622471, PubMed:8182049, PubMed:9553099). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:7622471, PubMed:8182049, PubMed:9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520). {ECO:0000269|PubMed:10636859, ECO:0000269|PubMed:15153520, ECO:0000269|PubMed:1847994, ECO:0000269|PubMed:29300009, ECO:0000269|PubMed:7622471, ECO:0000269|PubMed:8182049, ECO:0000269|PubMed:9553099}. |
| P22670 | RFX1 | S193 | ochoa | MHC class II regulatory factor RFX1 (Enhancer factor C) (EF-C) (Regulatory factor X 1) (RFX) (Transcription factor RFX1) | Regulatory factor essential for MHC class II genes expression. Binds to the X boxes of MHC class II genes. Also binds to an inverted repeat (ENH1) required for hepatitis B virus genes expression and to the most upstream element (alpha) of the RPL30 promoter. |
| P23246 | SFPQ | S283 | ochoa|psp | Splicing factor, proline- and glutamine-rich (100 kDa DNA-pairing protein) (hPOMp100) (DNA-binding p52/p100 complex, 100 kDa subunit) (Polypyrimidine tract-binding protein-associated-splicing factor) (PSF) (PTB-associated-splicing factor) | DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphorylation is proposed to lead to release from THRAP3 allowing binding to pre-mRNA splicing regulatotry elements which represses exon inclusion. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. May be involved in a pre-mRNA coupled splicing and polyadenylation process as component of a snRNP-free complex with SNRPA/U1A. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. SFPQ may be involved in homologous DNA pairing; in vitro, promotes the invasion of ssDNA between a duplex DNA and produces a D-loop formation. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1; in vitro, stimulates dissociation of TOP1 from DNA after cleavage and enhances its jumping between separate DNA helices. The SFPQ-NONO heteromer binds DNA (PubMed:25765647). The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends; in vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. SFPQ is involved in transcriptional regulation. Functions as a transcriptional activator (PubMed:25765647). Transcriptional repression is mediated by an interaction of SFPQ with SIN3A and subsequent recruitment of histone deacetylases (HDACs). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. SFPQ isoform Long binds to the DNA binding domains (DBD) of nuclear hormone receptors, like RXRA and probably THRA, and acts as a transcriptional corepressor in absence of hormone ligands. Binds the DNA sequence 5'-CTGAGTC-3' in the insulin-like growth factor response element (IGFRE) and inhibits IGF1-stimulated transcriptional activity. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation (By similarity). Required for the assembly of nuclear speckles (PubMed:25765647). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000250|UniProtKB:Q8VIJ6, ECO:0000269|PubMed:10847580, ECO:0000269|PubMed:10858305, ECO:0000269|PubMed:10931916, ECO:0000269|PubMed:11259580, ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:11897684, ECO:0000269|PubMed:15590677, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:25765647, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:8045264, ECO:0000269|PubMed:8449401}. |
| P28290 | ITPRID2 | S665 | ochoa | Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) | None |
| P29350 | PTPN6 | S186 | ochoa | Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Protein-tyrosine phosphatase SHP-1) (SH-PTP1) | Tyrosine phosphatase enzyme that plays important roles in controlling immune signaling pathways and fundamental physiological processes such as hematopoiesis (PubMed:14739280, PubMed:29925997). Dephosphorylates and negatively regulate several receptor tyrosine kinases (RTKs) such as EGFR, PDGFR and FGFR, thereby modulating their signaling activities (PubMed:21258366, PubMed:9733788). When recruited to immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing receptors such as immunoglobulin-like transcript 2/LILRB1, programmed cell death protein 1/PDCD1, CD3D, CD22, CLEC12A and other receptors involved in immune regulation, initiates their dephosphorylation and subsequently inhibits downstream signaling events (PubMed:11907092, PubMed:14739280, PubMed:37932456, PubMed:38166031). Modulates the signaling of several cytokine receptors including IL-4 receptor (PubMed:9065461). Additionally, targets multiple cytoplasmic signaling molecules including STING1, LCK or STAT1 among others involved in diverse cellular processes including modulation of T-cell activation or cGAS-STING signaling (PubMed:34811497, PubMed:38532423). Within the nucleus, negatively regulates the activity of some transcription factors such as NFAT5 via direct dephosphorylation. Also acts as a key transcriptional regulator of hepatic gluconeogenesis by controlling recruitment of RNA polymerase II to the PCK1 promoter together with STAT5A (PubMed:37595871). {ECO:0000269|PubMed:10574931, ECO:0000269|PubMed:11266449, ECO:0000269|PubMed:11907092, ECO:0000269|PubMed:14739280, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:29925997, ECO:0000269|PubMed:34811497, ECO:0000269|PubMed:37595871, ECO:0000269|PubMed:37932456, ECO:0000269|PubMed:38166031, ECO:0000269|PubMed:38532423, ECO:0000269|PubMed:9065461, ECO:0000269|PubMed:9733788}. |
| P32004 | L1CAM | S1194 | ochoa | Neural cell adhesion molecule L1 (N-CAM-L1) (NCAM-L1) (CD antigen CD171) | Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity. {ECO:0000269|PubMed:20621658, ECO:0000305}. |
| P33076 | CIITA | S1050 | psp | MHC class II transactivator (CIITA) (EC 2.3.1.-) (EC 2.7.11.1) | Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter (PubMed:16600381, PubMed:17493635, PubMed:7749984, PubMed:8402893). Does not bind DNA (PubMed:16600381, PubMed:17493635, PubMed:7749984, PubMed:8402893). May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both PubMed:8402893, PubMed:7749984, (PubMed:16600381, PubMed:17493635). Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter (PubMed:16600381, PubMed:17493635, PubMed:7749984, PubMed:8402893). Also mediates enhanced MHC class I transcription; the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Activates CD74 transcription (PubMed:32855215). Exhibits intrinsic GTP-stimulated acetyltransferase activity (PubMed:11172716). Exhibits serine/threonine protein kinase activity: can phosphorylate the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones (in vitro) (PubMed:24036077). Has antiviral activity against Ebola virus and coronaviruses, including SARS-CoV-2 (PubMed:32855215). Induces resistance by up-regulation of the p41 isoform of CD74, which blocks cathepsin-mediated cleavage of viral glycoproteins, thereby preventing viral fusion (PubMed:32855215). {ECO:0000269|PubMed:11172716, ECO:0000269|PubMed:16600381, ECO:0000269|PubMed:17493635, ECO:0000269|PubMed:24036077, ECO:0000269|PubMed:32855215, ECO:0000269|PubMed:7749984, ECO:0000269|PubMed:8402893}.; FUNCTION: [Isoform 3]: Exhibits dominant-negative suppression of MHC class II gene expression. {ECO:0000269|PubMed:12919287}. |
| P33993 | MCM7 | S500 | ochoa | DNA replication licensing factor MCM7 (EC 3.6.4.12) (CDC47 homolog) (P1.1-MCM3) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:25661590, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for S-phase checkpoint activation upon UV-induced damage. {ECO:0000269|PubMed:15210935, ECO:0000269|PubMed:15538388, ECO:0000269|PubMed:25661590, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9305914}. |
| P35573 | AGL | S894 | ochoa | Glycogen debranching enzyme (Glycogen debrancher) [Includes: 4-alpha-glucanotransferase (EC 2.4.1.25) (Oligo-1,4-1,4-glucantransferase); Amylo-alpha-1,6-glucosidase (Amylo-1,6-glucosidase) (EC 3.2.1.33) (Dextrin 6-alpha-D-glucosidase)] | Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. |
| P35606 | COPB2 | S787 | ochoa | Coatomer subunit beta' (Beta'-coat protein) (Beta'-COP) (p102) | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. {ECO:0000269|PubMed:34450031}.; FUNCTION: This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner (By similarity). {ECO:0000250}. |
| P35749 | MYH11 | S638 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
| P35813 | PPM1A | S190 | ochoa | Protein phosphatase 1A (EC 3.1.3.16) (Protein phosphatase 2C isoform alpha) (PP2C-alpha) (Protein phosphatase IA) | Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. {ECO:0000269|PubMed:16751101, ECO:0000269|PubMed:18930133}. |
| P38432 | COIL | S462 | ochoa | Coilin (p80-coilin) | Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs. {ECO:0000269|PubMed:7679389}. |
| P47755 | CAPZA2 | S215 | ochoa | F-actin-capping protein subunit alpha-2 (CapZ alpha-2) | F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. |
| P48444 | ARCN1 | S342 | ochoa | Coatomer subunit delta (Archain) (Delta-coat protein) (Delta-COP) | Component of the coatomer, a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}. |
| P49736 | MCM2 | S229 | ochoa | DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for the entry in S phase and for cell division (PubMed:8175912). Plays a role in terminally differentiated hair cells development of the cochlea and induces cells apoptosis (PubMed:26196677). {ECO:0000269|PubMed:26196677, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:8175912}. |
| P51114 | FXR1 | S423 | ochoa | RNA-binding protein FXR1 (FMR1 autosomal homolog 1) (hFXR1p) | mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for various processes, such as neurogenesis, muscle development and spermatogenesis (PubMed:17382880, PubMed:20417602, PubMed:30067974, PubMed:34731628, PubMed:35989368, PubMed:36306353). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:17382880, PubMed:34731628). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (By similarity). Required to activate translation of stored mRNAs during late spermatogenesis: acts by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules that recruit translation initiation factor EIF4G3 to activate translation of stored mRNAs in late spermatids (By similarity). Promotes translation of MYC transcripts by recruiting the eIF4F complex to the translation start site (PubMed:34731628). Acts as a negative regulator of inflammation in response to IL19 by promoting destabilization of pro-inflammatory transcripts (PubMed:30067974). Also acts as an inhibitor of inflammation by binding to TNF mRNA, decreasing TNF protein production (By similarity). Acts as a negative regulator of AMPA receptor GRIA2/GluA2 synthesis during long-lasting synaptic potentiation of hippocampal neurons by binding to GRIA2/GluA2 mRNA, thereby inhibiting its translation (By similarity). Regulates proliferation of adult neural stem cells by binding to CDKN1A mRNA and promoting its expression (By similarity). Acts as a regulator of sleep and synaptic homeostasis by regulating translation of transcripts in neurons (By similarity). Required for embryonic and postnatal development of muscle tissue by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules (PubMed:30770808). Involved in the nuclear pore complex localization to the nuclear envelope by preventing cytoplasmic aggregation of nucleoporins: acts by preventing ectopic phase separation of nucleoporins in the cytoplasm via a microtubule-dependent mechanism (PubMed:32706158). Plays a role in the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with PKP3 (PubMed:25225333). May also do the same for PKP2, PKP3 and DSP via its interaction with PKP1 (PubMed:25225333). Forms a cytoplasmic messenger ribonucleoprotein (mRNP) network by packaging long mRNAs, serving as a scaffold that recruits proteins and signaling molecules. This network facilitates signaling reactions by maintaining proximity between kinases and substrates, crucial for processes like actomyosin reorganization (PubMed:39106863). {ECO:0000250|UniProtKB:Q61584, ECO:0000269|PubMed:17382880, ECO:0000269|PubMed:20417602, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:30067974, ECO:0000269|PubMed:30770808, ECO:0000269|PubMed:32706158, ECO:0000269|PubMed:34731628, ECO:0000269|PubMed:35989368, ECO:0000269|PubMed:36306353, ECO:0000269|PubMed:39106863}. |
| P53350 | PLK1 | S450 | ochoa | Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13) | Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis (PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:23455478, PubMed:23509069, PubMed:28512243, PubMed:8991084). Polo-like kinase proteins act by binding and phosphorylating proteins that are already phosphorylated on a specific motif recognized by the POLO box domains (PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:23455478, PubMed:23509069, PubMed:28512243, PubMed:8991084). Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, MRE11, PPP1R12A/MYPT1, POLQ, PRC1, RACGAP1/CYK4, RAD51, RHNO1, SGO1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1, WEE1 and HNRNPU (PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17218258, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:22325354, PubMed:23455478, PubMed:23509069, PubMed:25986610, PubMed:26811421, PubMed:28512243, PubMed:37440612, PubMed:37674080, PubMed:8991084). Plays a key role in centrosome functions and the assembly of bipolar spindles by phosphorylating KIZ, NEDD1 and NINL (PubMed:16980960, PubMed:19509060). NEDD1 phosphorylation promotes subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation (PubMed:19509060). Phosphorylation of NINL component of the centrosome leads to NINL dissociation from other centrosomal proteins (PubMed:12852856). Involved in mitosis exit and cytokinesis by phosphorylating CEP55, ECT2, KIF20A/MKLP2, CENPU, PRC1 and RACGAP1 (PubMed:12939256, PubMed:16247472, PubMed:17351640, PubMed:19468300, PubMed:19468302). Recruited at the central spindle by phosphorylating and docking PRC1 and KIF20A/MKLP2; creates its own docking sites on PRC1 and KIF20A/MKLP2 by mediating phosphorylation of sites subsequently recognized by the POLO box domains (PubMed:12939256, PubMed:17351640). Phosphorylates RACGAP1, thereby creating a docking site for the Rho GTP exchange factor ECT2 that is essential for the cleavage furrow formation (PubMed:19468300, PubMed:19468302). Promotes the central spindle recruitment of ECT2 (PubMed:16247472). Plays a central role in G2/M transition of mitotic cell cycle by phosphorylating CCNB1, CDC25C, FOXM1, CENPU, PKMYT1/MYT1, PPP1R12A/MYPT1 and WEE1 (PubMed:11202906, PubMed:12447691, PubMed:12524548, PubMed:19160488). Part of a regulatory circuit that promotes the activation of CDK1 by phosphorylating the positive regulator CDC25C and inhibiting the negative regulators WEE1 and PKMYT1/MYT1 (PubMed:11202906). Also acts by mediating phosphorylation of cyclin-B1 (CCNB1) on centrosomes in prophase (PubMed:12447691, PubMed:12524548). Phosphorylates FOXM1, a key mitotic transcription regulator, leading to enhance FOXM1 transcriptional activity (PubMed:19160488). Involved in kinetochore functions and sister chromatid cohesion by phosphorylating BUB1B/BUBR1, FBXO5/EMI1 and STAG2/SA2 (PubMed:15148369, PubMed:15469984, PubMed:17376779, PubMed:18331714). PLK1 is high on non-attached kinetochores suggesting a role of PLK1 in kinetochore attachment or in spindle assembly checkpoint (SAC) regulation (PubMed:17617734). Required for kinetochore localization of BUB1B (PubMed:17376779). Regulates the dissociation of cohesin from chromosomes by phosphorylating cohesin subunits such as STAG2/SA2 (By similarity). Phosphorylates SGO1: required for spindle pole localization of isoform 3 of SGO1 and plays a role in regulating its centriole cohesion function (PubMed:18331714). Mediates phosphorylation of FBXO5/EMI1, a negative regulator of the APC/C complex during prophase, leading to FBXO5/EMI1 ubiquitination and degradation by the proteasome (PubMed:15148369, PubMed:15469984). Acts as a negative regulator of p53 family members: phosphorylates TOPORS, leading to inhibit the sumoylation of p53/TP53 and simultaneously enhance the ubiquitination and subsequent degradation of p53/TP53 (PubMed:19473992). Phosphorylates the transactivation domain of the transcription factor p73/TP73, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates BORA, and thereby promotes the degradation of BORA (PubMed:18521620). Contributes to the regulation of AURKA function (PubMed:18615013, PubMed:18662541). Also required for recovery after DNA damage checkpoint and entry into mitosis (PubMed:18615013, PubMed:18662541). Phosphorylates MISP, leading to stabilization of cortical and astral microtubule attachments required for proper spindle positioning (PubMed:23509069). Together with MEIKIN, acts as a regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage (By similarity). Phosphorylates CEP68 and is required for its degradation (PubMed:25503564). Regulates nuclear envelope breakdown during prophase by phosphorylating DCTN1 resulting in its localization in the nuclear envelope (PubMed:20679239). Phosphorylates the heat shock transcription factor HSF1, promoting HSF1 nuclear translocation upon heat shock (PubMed:15661742). Phosphorylates HSF1 also in the early mitotic period; this phosphorylation regulates HSF1 localization to the spindle pole, the recruitment of the SCF(BTRC) ubiquitin ligase complex induicing HSF1 degradation, and hence mitotic progression (PubMed:18794143). Regulates mitotic progression by phosphorylating RIOK2 (PubMed:21880710). Through the phosphorylation of DZIP1 regulates the localization during mitosis of the BBSome, a ciliary protein complex involved in cilium biogenesis (PubMed:27979967). Regulates DNA repair during mitosis by mediating phosphorylation of POLQ and RHNO1, thereby promoting POLQ recruitment to DNA damage sites (PubMed:37440612, PubMed:37674080). Phosphorylates ATXN10 which may play a role in the regulation of cytokinesis and may stimulate the proteasome-mediated degradation of ATXN10 (PubMed:21857149). {ECO:0000250|UniProtKB:P70032, ECO:0000250|UniProtKB:Q5F2C3, ECO:0000269|PubMed:11202906, ECO:0000269|PubMed:12207013, ECO:0000269|PubMed:12447691, ECO:0000269|PubMed:12524548, ECO:0000269|PubMed:12738781, ECO:0000269|PubMed:12852856, ECO:0000269|PubMed:12939256, ECO:0000269|PubMed:14532005, ECO:0000269|PubMed:14734534, ECO:0000269|PubMed:15070733, ECO:0000269|PubMed:15148369, ECO:0000269|PubMed:15469984, ECO:0000269|PubMed:15661742, ECO:0000269|PubMed:16198290, ECO:0000269|PubMed:16247472, ECO:0000269|PubMed:16980960, ECO:0000269|PubMed:17081991, ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:17351640, ECO:0000269|PubMed:17376779, ECO:0000269|PubMed:17617734, ECO:0000269|PubMed:18174154, ECO:0000269|PubMed:18331714, ECO:0000269|PubMed:18418051, ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:18521620, ECO:0000269|PubMed:18615013, ECO:0000269|PubMed:18662541, ECO:0000269|PubMed:18794143, ECO:0000269|PubMed:19160488, ECO:0000269|PubMed:19351716, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19468302, ECO:0000269|PubMed:19473992, ECO:0000269|PubMed:19509060, ECO:0000269|PubMed:19597481, ECO:0000269|PubMed:20679239, ECO:0000269|PubMed:21857149, ECO:0000269|PubMed:21880710, ECO:0000269|PubMed:22325354, ECO:0000269|PubMed:23455478, ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:25986610, ECO:0000269|PubMed:26811421, ECO:0000269|PubMed:27979967, ECO:0000269|PubMed:37440612, ECO:0000269|PubMed:37674080, ECO:0000269|PubMed:8991084}. |
| P54259 | ATN1 | S107 | ochoa | Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein) | Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats. {ECO:0000250|UniProtKB:O35126, ECO:0000269|PubMed:10085113, ECO:0000269|PubMed:10973986}. |
| P55196 | AFDN | S1510 | ochoa | Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor) | Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). {ECO:0000250|UniProtKB:O35889, ECO:0000250|UniProtKB:Q9QZQ1, ECO:0000269|PubMed:11024295, ECO:0000269|PubMed:30463011}. |
| P56537 | EIF6 | S175 | ochoa|psp | Eukaryotic translation initiation factor 6 (eIF-6) (B(2)GCN homolog) (B4 integrin interactor) (CAB) (p27(BBP)) | Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm (PubMed:10085284, PubMed:14654845, PubMed:21536732, PubMed:32669547). Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity (PubMed:10085284, PubMed:14654845, PubMed:21536732). In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis (By similarity). Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:17507929). Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth (By similarity). {ECO:0000255|HAMAP-Rule:MF_03132, ECO:0000269|PubMed:10085284, ECO:0000269|PubMed:14654845, ECO:0000269|PubMed:17507929, ECO:0000269|PubMed:21536732, ECO:0000269|PubMed:32669547}. |
| P57078 | RIPK4 | S434 | ochoa | Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain-containing protein 3) (PKC-delta-interacting protein kinase) | Serine/threonine protein kinase (By similarity). Required for embryonic skin development and correct skin homeostasis in adults, via phosphorylation of PKP1 and subsequent promotion of keratinocyte differentiation and cell adhesion (By similarity). It is a direct transcriptional target of TP63 (PubMed:22197488). Plays a role in NF-kappa-B activation (PubMed:12446564). {ECO:0000250|UniProtKB:Q9ERK0, ECO:0000269|PubMed:12446564, ECO:0000269|PubMed:22197488}. |
| P60709 | ACTB | S348 | ochoa | Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] | Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (PubMed:39321809, PubMed:38609661). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:Q6QAQ1, ECO:0000269|PubMed:25255767, ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| P62701 | RPS4X | S237 | ochoa | Small ribosomal subunit protein eS4, X isoform (40S ribosomal protein S4) (SCR10) (Single copy abundant mRNA protein) | Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| P63261 | ACTG1 | S348 | ochoa | Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage (By similarity). {ECO:0000250|UniProtKB:P63260, ECO:0000305|PubMed:29581253}. |
| P82979 | SARNP | S115 | ochoa | SAP domain-containing ribonucleoprotein (Cytokine-induced protein of 29 kDa) (Nuclear protein Hcc-1) (Proliferation-associated cytokine-inducible protein CIP29) | Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15338056, PubMed:17196963, PubMed:20844015). The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15338056, PubMed:17196963, PubMed:20844015). Associates with DDX39B, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export (PubMed:37578863). {ECO:0000269|PubMed:15338056, ECO:0000269|PubMed:17196963, ECO:0000269|PubMed:20844015, ECO:0000269|PubMed:37578863}. |
| P98082 | DAB2 | S723 | ochoa|psp | Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Differentially-expressed protein 2) | Adapter protein that functions as a clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. May act as a tumor suppressor. {ECO:0000269|PubMed:11387212, ECO:0000269|PubMed:12805222, ECO:0000269|PubMed:16267015, ECO:0000269|PubMed:16984970, ECO:0000269|PubMed:19306879, ECO:0000269|PubMed:21995445, ECO:0000269|PubMed:22323290, ECO:0000269|PubMed:22491013}. |
| Q01201 | RELB | S254 | ochoa | Transcription factor RelB (I-Rel) | NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer in a CRY1/CRY2 independent manner. Increased repression of the heterodimer is seen in the presence of NFKB2/p52. Is required for both T and B lymphocyte maturation and function (PubMed:26385063). {ECO:0000269|PubMed:1732739, ECO:0000269|PubMed:22565310, ECO:0000269|PubMed:26385063, ECO:0000269|PubMed:7925301, ECO:0000269|PubMed:8441398}. |
| Q07343 | PDE4B | S319 | ochoa | 3',5'-cyclic-AMP phosphodiesterase 4B (EC 3.1.4.53) (DPDE4) (PDE32) (cAMP-specific phosphodiesterase 4B) | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:15260978). May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents. {ECO:0000269|PubMed:10846163, ECO:0000269|PubMed:15003452, ECO:0000269|PubMed:15260978}. |
| Q08495 | DMTN | S333 | ochoa | Dematin (Dematin actin-binding protein) (Erythrocyte membrane protein band 4.9) | Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Also plays a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation. {ECO:0000269|PubMed:10565303, ECO:0000269|PubMed:11856323, ECO:0000269|PubMed:18347014, ECO:0000269|PubMed:19241372, ECO:0000269|PubMed:22927433, ECO:0000269|PubMed:23355471}. |
| Q12888 | TP53BP1 | S1002 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12923 | PTPN13 | S502 | ochoa | Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1) (PTP-BAS) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (Protein-tyrosine phosphatase PTPL1) | Tyrosine phosphatase which negatively regulates FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317). {ECO:0000269|PubMed:15611135, ECO:0000269|PubMed:23604317}. |
| Q13085 | ACACA | S835 | ochoa | Acetyl-CoA carboxylase 1 (ACC1) (EC 6.4.1.2) (Acetyl-Coenzyme A carboxylase alpha) (ACC-alpha) | Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis (PubMed:20457939, PubMed:20952656, PubMed:29899443). This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:20457939, PubMed:20952656, PubMed:29899443). {ECO:0000269|PubMed:20457939, ECO:0000269|PubMed:20952656, ECO:0000269|PubMed:29899443}. |
| Q13263 | TRIM28 | S489 | ochoa | Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28) | Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also a corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:Q62318, ECO:0000269|PubMed:10347202, ECO:0000269|PubMed:11959841, ECO:0000269|PubMed:15882967, ECO:0000269|PubMed:16107876, ECO:0000269|PubMed:16862143, ECO:0000269|PubMed:17079232, ECO:0000269|PubMed:17178852, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17942393, ECO:0000269|PubMed:18060868, ECO:0000269|PubMed:18082607, ECO:0000269|PubMed:20424263, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:21940674, ECO:0000269|PubMed:23543754, ECO:0000269|PubMed:23665872, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:8769649, ECO:0000269|PubMed:9016654}.; FUNCTION: (Microbial infection) Plays a critical role in the shutdown of lytic gene expression during the early stage of herpes virus 8 primary infection. This inhibition is mediated through interaction with herpes virus 8 protein LANA1. {ECO:0000269|PubMed:24741090}. |
| Q13615 | MTMR3 | S652 | ochoa | Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3 (EC 3.1.3.95) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Myotubularin-related protein 3) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (Phosphatidylinositol-3-phosphate phosphatase) (Zinc finger FYVE domain-containing protein 10) | Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate (PubMed:10733931, PubMed:11302699, PubMed:11676921, PubMed:12646134). Decreases the levels of phosphatidylinositol 3-phosphate, a phospholipid found in cell membranes where it acts as key regulator of both cell signaling and intracellular membrane traffic (PubMed:11302699, PubMed:11676921, PubMed:12646134). Could also have a molecular sequestering/adapter activity and regulate biological processes independently of its phosphatase activity. It includes the regulation of midbody abscission during mitotic cytokinesis (PubMed:25659891). {ECO:0000269|PubMed:10733931, ECO:0000269|PubMed:11302699, ECO:0000269|PubMed:11676921, ECO:0000269|PubMed:12646134, ECO:0000269|PubMed:25659891}. |
| Q13796 | SHROOM2 | S180 | ochoa | Protein Shroom2 (Apical-like protein) (Protein APXL) | May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). {ECO:0000250}. |
| Q14160 | SCRIB | S1378 | ochoa|psp | Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) | Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}. |
| Q14258 | TRIM25 | S435 | ochoa | E3 ubiquitin/ISG15 ligase TRIM25 (EC 6.3.2.n3) (Estrogen-responsive finger protein) (RING finger protein 147) (RING-type E3 ubiquitin transferase) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM25) (Tripartite motif-containing protein 25) (Ubiquitin/ISG15-conjugating enzyme TRIM25) (Zinc finger protein 147) | Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase (PubMed:16352599). Involved in innate immune defense against viruses by mediating ubiquitination of RIGI and IFIH1 (PubMed:17392790, PubMed:29357390, PubMed:30193849, PubMed:31710640, PubMed:33849980, PubMed:36045682). Mediates 'Lys-63'-linked polyubiquitination of the RIGI N-terminal CARD-like region and may play a role in signal transduction that leads to the production of interferons in response to viral infection (PubMed:17392790, PubMed:23950712). Mediates 'Lys-63'-linked polyubiquitination of IFIH1 (PubMed:30193849). Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway (PubMed:16352599, PubMed:17069755). Mediates estrogen action in various target organs (PubMed:22452784). Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3 (PubMed:22452784). Plays a role in promoting the restart of stalled replication forks via interaction with the KHDC3L-OOEP scaffold and subsequent ubiquitination of BLM, resulting in the recruitment and retainment of BLM at DNA replication forks (By similarity). Plays an essential role in the antiviral activity of ZAP/ZC3HAV1; an antiviral protein which inhibits the replication of certain viruses. Mechanistically, mediates 'Lys-63'-linked polyubiquitination of ZAP/ZC3HAV1 that is required for its optimal binding to target mRNA (PubMed:28060952, PubMed:28202764). Also mediates the ubiquitination of various substrates implicated in stress granule formation, nonsense-mediated mRNA decay, nucleoside synthesis and mRNA translation and stability (PubMed:36067236). {ECO:0000250|UniProtKB:Q61510, ECO:0000269|PubMed:16352599, ECO:0000269|PubMed:17069755, ECO:0000269|PubMed:17392790, ECO:0000269|PubMed:22452784, ECO:0000269|PubMed:23950712, ECO:0000269|PubMed:29357390, ECO:0000269|PubMed:30193849, ECO:0000269|PubMed:31710640, ECO:0000269|PubMed:33849980, ECO:0000269|PubMed:36045682, ECO:0000269|PubMed:36067236}. |
| Q14451 | GRB7 | S411 | ochoa | Growth factor receptor-bound protein 7 (B47) (Epidermal growth factor receptor GRB-7) (GRB7 adapter protein) | Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity). {ECO:0000250, ECO:0000269|PubMed:10893408, ECO:0000269|PubMed:12021278, ECO:0000269|PubMed:12223469, ECO:0000269|PubMed:20622016}. |
| Q14653 | IRF3 | S402 | psp | Interferon regulatory factor 3 (IRF-3) | Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses (PubMed:22394562, PubMed:24049179, PubMed:25636800, PubMed:27302953, PubMed:31340999, PubMed:36603579, PubMed:8524823). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:11846977, PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:32972995, PubMed:36603579, PubMed:8524823). Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction (PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:36603579). Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases (PubMed:22394562, PubMed:25636800, PubMed:27302953, PubMed:36603579). This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes (PubMed:16154084, PubMed:27302953, PubMed:33440148, PubMed:36603579). Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages (PubMed:16846591). In response to Sendai virus infection, is recruited by TOMM70:HSP90AA1 to mitochondrion and forms an apoptosis complex TOMM70:HSP90AA1:IRF3:BAX inducing apoptosis (PubMed:25609812). Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000269|PubMed:16154084, ECO:0000269|PubMed:22394562, ECO:0000269|PubMed:24049179, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27302953, ECO:0000269|PubMed:31340999, ECO:0000269|PubMed:31413131, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:33440148, ECO:0000269|PubMed:36603579, ECO:0000269|PubMed:8524823, ECO:0000303|PubMed:11846977, ECO:0000303|PubMed:16846591, ECO:0000303|PubMed:16979567, ECO:0000303|PubMed:20049431}. |
| Q14764 | MVP | S445 | ochoa | Major vault protein (MVP) (Lung resistance-related protein) | Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases. {ECO:0000269|PubMed:15133037, ECO:0000269|PubMed:16418217, ECO:0000269|PubMed:16441665}. |
| Q15043 | SLC39A14 | S309 | ochoa | Metal cation symporter ZIP14 (LIV-1 subfamily of ZIP zinc transporter 4) (LZT-Hs4) (Solute carrier family 39 member 14) (Zrt- and Irt-like protein 14) (ZIP-14) | Electroneutral transporter of the plasma membrane mediating the cellular uptake of the divalent metal cations zinc, manganese and iron that are important for tissue homeostasis, metabolism, development and immunity (PubMed:15642354, PubMed:27231142, PubMed:29621230). Functions as an energy-dependent symporter, transporting through the membranes an electroneutral complex composed of a divalent metal cation and two bicarbonate anions (By similarity). Beside these endogenous cellular substrates, can also import cadmium a non-essential metal which is cytotoxic and carcinogenic (By similarity). Controls the cellular uptake by the intestinal epithelium of systemic zinc, which is in turn required to maintain tight junctions and the intestinal permeability (By similarity). Modifies the activity of zinc-dependent phosphodiesterases, thereby indirectly regulating G protein-coupled receptor signaling pathways important for gluconeogenesis and chondrocyte differentiation (By similarity). Regulates insulin receptor signaling, glucose uptake, glycogen synthesis and gluconeogenesis in hepatocytes through the zinc-dependent intracellular catabolism of insulin (PubMed:27703010). Through zinc cellular uptake also plays a role in the adaptation of cells to endoplasmic reticulum stress (By similarity). Major manganese transporter of the basolateral membrane of intestinal epithelial cells, it plays a central role in manganese systemic homeostasis through intestinal manganese uptake (PubMed:31028174). Also involved in manganese extracellular uptake by cells of the blood-brain barrier (PubMed:31699897). May also play a role in manganese and zinc homeostasis participating in their elimination from the blood through the hepatobiliary excretion (By similarity). Also functions in the extracellular uptake of free iron. May also function intracellularly and mediate the transport from endosomes to cytosol of iron endocytosed by transferrin (PubMed:20682781). Plays a role in innate immunity by regulating the expression of cytokines by activated macrophages (PubMed:23052185). {ECO:0000250|UniProtKB:Q75N73, ECO:0000269|PubMed:15642354, ECO:0000269|PubMed:20682781, ECO:0000269|PubMed:23052185, ECO:0000269|PubMed:27231142, ECO:0000269|PubMed:27703010, ECO:0000269|PubMed:29621230, ECO:0000269|PubMed:31028174, ECO:0000269|PubMed:31699897}. |
| Q15056 | EIF4H | S110 | ochoa | Eukaryotic translation initiation factor 4H (eIF-4H) (Williams-Beuren syndrome chromosomal region 1 protein) | Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA. {ECO:0000269|PubMed:10585411, ECO:0000269|PubMed:11418588}. |
| Q15208 | STK38 | S252 | ochoa | Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1) | Serine/threonine-protein kinase that acts as a negative regulator of MAP3K1/2 signaling (PubMed:12493777, PubMed:15197186, PubMed:17906693, PubMed:7761441). Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2 (PubMed:12493777, PubMed:15197186, PubMed:17906693, PubMed:7761441). Acts as an ufmylation 'reader' in a kinase-independent manner: specifically recognizes and binds mono-ufmylated histone H4 in response to DNA damage, promoting the recruitment of SUV39H1 to the double-strand breaks, resulting in ATM activation (PubMed:32537488). {ECO:0000269|PubMed:12493777, ECO:0000269|PubMed:15197186, ECO:0000269|PubMed:17906693, ECO:0000269|PubMed:32537488, ECO:0000269|PubMed:7761441}. |
| Q15233 | NONO | S149 | ochoa | Non-POU domain-containing octamer-binding protein (NonO protein) (54 kDa nuclear RNA- and DNA-binding protein) (p54(nrb)) (p54nrb) (55 kDa nuclear protein) (NMT55) (DNA-binding p52/p100 complex, 52 kDa subunit) | DNA- and RNA binding protein, involved in several nuclear processes (PubMed:11525732, PubMed:12403470, PubMed:26571461). Binds the conventional octamer sequence in double-stranded DNA (PubMed:11525732, PubMed:12403470, PubMed:26571461). Also binds single-stranded DNA and RNA at a site independent of the duplex site (PubMed:11525732, PubMed:12403470, PubMed:26571461). Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ (PubMed:11525732, PubMed:12403470, PubMed:26571461). Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b (PubMed:12403470). Together with PSPC1, required for the formation of nuclear paraspeckles (PubMed:22416126). The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs (PubMed:11525732). The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1 (PubMed:10858305). The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends (PubMed:15590677). In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex (PubMed:15590677). NONO is involved in transcriptional regulation. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity (PubMed:11897684). NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription (By similarity). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (By similarity). Important for the functional organization of GABAergic synapses (By similarity). Plays a specific and important role in the regulation of synaptic RNAs and GPHN/gephyrin scaffold structure, through the regulation of GABRA2 transcript (By similarity). Plays a key role during neuronal differentiation by recruiting TET1 to genomic loci and thereby regulating 5-hydroxymethylcytosine levels (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728, PubMed:30270045). Promotes activation of the cGAS-STING pathway in response to HIV-2 infection: acts by interacting with HIV-2 Capsid protein p24, thereby promoting detection of viral DNA by CGAS, leading to CGAS-mediated inmmune activation (PubMed:30270045). In contrast, the weak interaction with HIV-1 Capsid protein p24 does not allow activation of the cGAS-STING pathway (PubMed:30270045). {ECO:0000250|UniProtKB:Q99K48, ECO:0000269|PubMed:10858305, ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:11897684, ECO:0000269|PubMed:12403470, ECO:0000269|PubMed:15590677, ECO:0000269|PubMed:22416126, ECO:0000269|PubMed:26571461, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:30270045}. |
| Q15334 | LLGL1 | S488 | ochoa | Lethal(2) giant larvae protein homolog 1 (LLGL) (DLG4) (Hugl-1) (Human homolog to the D-lgl gene protein) | Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane. {ECO:0000269|PubMed:15735678, ECO:0000269|PubMed:16170365}. |
| Q15772 | SPEG | S516 | ochoa | Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) | Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. |
| Q29980 | MICB | S345 | ochoa | MHC class I polypeptide-related sequence B (MIC-B) | Widely expressed membrane-bound protein which acts as a ligand to stimulate an activating receptor KLRK1/NKG2D, expressed on the surface of essentially all human natural killer (NK), gammadelta T and CD8+ alphabeta T-cells (PubMed:11491531, PubMed:11777960). Up-regulated in stressed conditions, such as viral and bacterial infections or DNA damage response, serves as signal of cellular stress, and engagement of KLRK1/NKG2D by MICA triggers NK-cells resulting in a range of immune effector functions, such as cytotoxicity and cytokine production. {ECO:0000269|PubMed:11491531, ECO:0000269|PubMed:11777960, ECO:0000269|PubMed:9497295}. |
| Q29983 | MICA | S345 | ochoa | MHC class I polypeptide-related sequence A (MIC-A) | Widely expressed membrane-bound protein which acts as a ligand to stimulate an activating receptor KLRK1/NKG2D, expressed on the surface of essentially all human natural killer (NK), gammadelta T and CD8 alphabeta T-cells (PubMed:11491531, PubMed:11777960). Up-regulated in stressed conditions, such as viral and bacterial infections or DNA damage response, serves as signal of cellular stress, and engagement of KLRK1/NKG2D by MICA triggers NK-cells resulting in a range of immune effector functions, such as cytotoxicity and cytokine production (PubMed:10426993). {ECO:0000269|PubMed:10426993, ECO:0000269|PubMed:11224526, ECO:0000269|PubMed:11491531, ECO:0000269|PubMed:11777960, ECO:0000269|PubMed:9497295}. |
| Q3MJ13 | WDR72 | S970 | ochoa | WD repeat-containing protein 72 | Plays a major role in formation of tooth enamel (PubMed:19853237, PubMed:25008349). Specifically required during the maturation phase of amelogenesis for normal formation of the enamel matrix and clearance of enamel proteins. May be involved in localization of the calcium transporter SLC24A4 to the ameloblast cell membrane. {ECO:0000250|UniProtKB:D3YYM4, ECO:0000269|PubMed:19853237, ECO:0000269|PubMed:25008349}. |
| Q3V6T2 | CCDC88A | S1449 | ochoa | Girdin (Akt phosphorylation enhancer) (APE) (Coiled-coil domain-containing protein 88A) (G alpha-interacting vesicle-associated protein) (GIV) (Girders of actin filament) (Hook-related protein 1) (HkRP1) | Bifunctional modulator of guanine nucleotide-binding proteins (G proteins) (PubMed:19211784, PubMed:27621449). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein G(i) alpha subunits (PubMed:19211784, PubMed:21954290, PubMed:23509302, PubMed:25187647). Also acts as a guanine nucleotide dissociation inhibitor for guanine nucleotide-binding protein G(s) subunit alpha GNAS (PubMed:27621449). Essential for cell migration (PubMed:16139227, PubMed:19211784, PubMed:20462955, PubMed:21954290). Interacts in complex with G(i) alpha subunits with the EGFR receptor, retaining EGFR at the cell membrane following ligand stimulation and promoting EGFR signaling which triggers cell migration (PubMed:20462955). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex which enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB (PubMed:19211784). Phosphorylation of AKT1/PKB induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Binds in its tyrosine-phosphorylated form to the phosphatidylinositol 3-kinase (PI3K) regulatory subunit PIK3R1 which enables recruitment of PIK3R1 to the EGFR receptor, enhancing PI3K activity and cell migration (PubMed:21954290). Plays a role as a key modulator of the AKT-mTOR signaling pathway, controlling the tempo of the process of newborn neuron integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Inhibition of G(s) subunit alpha GNAS leads to reduced cellular levels of cAMP and suppression of cell proliferation (PubMed:27621449). Essential for the integrity of the actin cytoskeleton (PubMed:16139227, PubMed:19211784). Required for formation of actin stress fibers and lamellipodia (PubMed:15882442). May be involved in membrane sorting in the early endosome (PubMed:15882442). Plays a role in ciliogenesis and cilium morphology and positioning and this may partly be through regulation of the localization of scaffolding protein CROCC/Rootletin (PubMed:27623382). {ECO:0000250|UniProtKB:Q5SNZ0, ECO:0000269|PubMed:15882442, ECO:0000269|PubMed:16139227, ECO:0000269|PubMed:19211784, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:21954290, ECO:0000269|PubMed:23509302, ECO:0000269|PubMed:25187647, ECO:0000269|PubMed:27621449, ECO:0000269|PubMed:27623382}. |
| Q3V6T2 | CCDC88A | S1603 | ochoa | Girdin (Akt phosphorylation enhancer) (APE) (Coiled-coil domain-containing protein 88A) (G alpha-interacting vesicle-associated protein) (GIV) (Girders of actin filament) (Hook-related protein 1) (HkRP1) | Bifunctional modulator of guanine nucleotide-binding proteins (G proteins) (PubMed:19211784, PubMed:27621449). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein G(i) alpha subunits (PubMed:19211784, PubMed:21954290, PubMed:23509302, PubMed:25187647). Also acts as a guanine nucleotide dissociation inhibitor for guanine nucleotide-binding protein G(s) subunit alpha GNAS (PubMed:27621449). Essential for cell migration (PubMed:16139227, PubMed:19211784, PubMed:20462955, PubMed:21954290). Interacts in complex with G(i) alpha subunits with the EGFR receptor, retaining EGFR at the cell membrane following ligand stimulation and promoting EGFR signaling which triggers cell migration (PubMed:20462955). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex which enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB (PubMed:19211784). Phosphorylation of AKT1/PKB induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Binds in its tyrosine-phosphorylated form to the phosphatidylinositol 3-kinase (PI3K) regulatory subunit PIK3R1 which enables recruitment of PIK3R1 to the EGFR receptor, enhancing PI3K activity and cell migration (PubMed:21954290). Plays a role as a key modulator of the AKT-mTOR signaling pathway, controlling the tempo of the process of newborn neuron integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Inhibition of G(s) subunit alpha GNAS leads to reduced cellular levels of cAMP and suppression of cell proliferation (PubMed:27621449). Essential for the integrity of the actin cytoskeleton (PubMed:16139227, PubMed:19211784). Required for formation of actin stress fibers and lamellipodia (PubMed:15882442). May be involved in membrane sorting in the early endosome (PubMed:15882442). Plays a role in ciliogenesis and cilium morphology and positioning and this may partly be through regulation of the localization of scaffolding protein CROCC/Rootletin (PubMed:27623382). {ECO:0000250|UniProtKB:Q5SNZ0, ECO:0000269|PubMed:15882442, ECO:0000269|PubMed:16139227, ECO:0000269|PubMed:19211784, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:21954290, ECO:0000269|PubMed:23509302, ECO:0000269|PubMed:25187647, ECO:0000269|PubMed:27621449, ECO:0000269|PubMed:27623382}. |
| Q53EZ4 | CEP55 | S396 | ochoa | Centrosomal protein of 55 kDa (Cep55) (Up-regulated in colon cancer 6) | Plays a role in mitotic exit and cytokinesis (PubMed:16198290, PubMed:17853893). Recruits PDCD6IP and TSG101 to midbody during cytokinesis. Required for successful completion of cytokinesis (PubMed:17853893). Not required for microtubule nucleation (PubMed:16198290). Plays a role in the development of the brain and kidney (PubMed:28264986). {ECO:0000269|PubMed:16198290, ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:28264986}. |
| Q53S48 | STON1-GTF2A1L | S244 | ochoa | Stonin-1 (Stoned B-like factor) | May be involved in the endocytic machinery. {ECO:0000256|ARBA:ARBA00059680}. |
| Q53T59 | HS1BP3 | S280 | ochoa | HCLS1-binding protein 3 (HS1-binding protein 3) (HSP1BP-3) | May be a modulator of IL-2 signaling. {ECO:0000250}. |
| Q58FF6 | HSP90AB4P | S34 | ochoa | Putative heat shock protein HSP 90-beta 4 | Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}. |
| Q58FF7 | HSP90AB3P | S58 | ochoa | Putative heat shock protein HSP 90-beta-3 (Heat shock protein 90-beta c) (Heat shock protein 90Bc) | Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}. |
| Q58FF8 | HSP90AB2P | S58 | ochoa | Putative heat shock protein HSP 90-beta 2 (Heat shock protein 90-beta b) (Heat shock protein 90Bb) | Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}. |
| Q5JTC6 | AMER1 | S324 | psp | APC membrane recruitment protein 1 (Amer1) (Protein FAM123B) (Wilms tumor gene on the X chromosome protein) | Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development. {ECO:0000269|PubMed:17510365, ECO:0000269|PubMed:17925383, ECO:0000269|PubMed:19416806, ECO:0000269|PubMed:21304492, ECO:0000269|PubMed:21498506}. |
| Q5T200 | ZC3H13 | S1409 | ochoa | Zinc finger CCCH domain-containing protein 13 | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}. |
| Q5T7B8 | KIF24 | S478 | ochoa | Kinesin-like protein KIF24 | Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation (PubMed:21620453). Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle (PubMed:26290419). Plays an important role in recruiting MPHOSPH9, a negative regulator of cilia formation to the distal end of mother centriole (PubMed:30375385). {ECO:0000269|PubMed:21620453, ECO:0000269|PubMed:26290419, ECO:0000269|PubMed:30375385}. |
| Q5TGY3 | AHDC1 | S1200 | ochoa | Transcription factor Gibbin (AT-hook DNA-binding motif-containing protein 1) | Transcription factor required for the proper patterning of the epidermis, which plays a key role in early epithelial morphogenesis (PubMed:35585237). Directly binds promoter and enhancer regions and acts by maintaining local enhancer-promoter chromatin architecture (PubMed:35585237). Interacts with many sequence-specific zinc-finger transcription factors and methyl-CpG-binding proteins to regulate the expression of mesoderm genes that wire surface ectoderm stratification (PubMed:35585237). {ECO:0000269|PubMed:35585237}. |
| Q5TH69 | ARFGEF3 | S2101 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 3 (ARFGEF family member 3) | Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (By similarity). Also regulates glucagon granule production in pancreatic alpha cells (By similarity). Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells (PubMed:19496786). {ECO:0000250|UniProtKB:Q3UGY8, ECO:0000269|PubMed:19496786}. |
| Q5THJ4 | VPS13D | S1724 | ochoa | Intermembrane lipid transfer protein VPS13D (Vacuolar protein sorting-associated protein 13D) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:29307555, ECO:0000269|PubMed:29604224}. |
| Q641Q2 | WASHC2A | S688 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
| Q68CZ2 | TNS3 | S440 | ochoa | Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6) | May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex (PubMed:17643115). EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1 (PubMed:17643115). Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA (PubMed:26166433). Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration (PubMed:35687021). Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1 (PubMed:31905841). {ECO:0000250|UniProtKB:Q5SSZ5, ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:31905841, ECO:0000269|PubMed:35687021, ECO:0000305}. |
| Q68DQ2 | CRYBG3 | S316 | ochoa | Very large A-kinase anchor protein (vlAKAP) (Beta/gamma crystallin domain-containing protein 3) | [Isoform vlAKAP]: Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA). {ECO:0000269|PubMed:25097019}. |
| Q6NUP7 | PPP4R4 | S150 | ochoa | Serine/threonine-protein phosphatase 4 regulatory subunit 4 | Putative regulatory subunit of serine/threonine-protein phosphatase 4. |
| Q6P3S1 | DENND1B | S590 | ochoa | DENN domain-containing protein 1B (Connecdenn 2) (Protein FAM31B) | Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of T-cell receptor (TCR) internalization in TH2 cells (PubMed:20154091, PubMed:20937701, PubMed:24520163, PubMed:26774822). Acts by promoting the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form (PubMed:20154091, PubMed:20937701). Plays a role in clathrin-mediated endocytosis (PubMed:20154091). Controls cytokine production in TH2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes: acts by mediating clathrin-mediated endocytosis of TCR via its interaction with the adapter protein complex 2 (AP-2) and GEF activity (PubMed:26774822). Dysregulation leads to impaired TCR down-modulation and recycling, affecting cytokine production in TH2 cells (PubMed:26774822). {ECO:0000269|PubMed:20154091, ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:24520163, ECO:0000269|PubMed:26774822}. |
| Q6ZV73 | FGD6 | S503 | ochoa | FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24) | May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity). {ECO:0000250}. |
| Q6ZVF9 | GPRIN3 | S526 | ochoa | G protein-regulated inducer of neurite outgrowth 3 (GRIN3) | May be involved in neurite outgrowth. {ECO:0000250}. |
| Q7RTP6 | MICAL3 | S899 | ochoa | [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3) | Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. {ECO:0000269|PubMed:21596566, ECO:0000269|PubMed:24440334}. |
| Q7Z2D5 | PLPPR4 | S346 | ochoa | Phospholipid phosphatase-related protein type 4 (Brain-specific phosphatidic acid phosphatase-like protein 1) (Inactive 2-lysophosphatidate phosphatase PLPPR4) (Lipid phosphate phosphatase-related protein type 4) (Plasticity-related gene 1 protein) (PRG-1) | Postsynaptic density membrane protein that indirectly regulates glutamatergic synaptic transmission through lysophosphatidic acid (LPA)-mediated signaling pathways. Binds lysophosphatidic acid (LPA) and mediates its internalization into cells. Could act as receptor or a transporter of this lipid at the post-synaptic membrane (By similarity). Modulates lysophosphatidic acid (LPA) activity in neuron axonal outgrowth during development by attenuating phospholipid-induced axon collapse (By similarity). {ECO:0000250|UniProtKB:Q7TMB7, ECO:0000250|UniProtKB:Q7TME0}. |
| Q7Z401 | DENND4A | S1609 | ochoa | C-myc promoter-binding protein (DENN domain-containing protein 4A) | Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter. {ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:8056341}. |
| Q7Z4H7 | HAUS6 | S524 | ochoa | HAUS augmin-like complex subunit 6 | Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Promotes the nucleation of microtubules from the spindle through recruitment of NEDD1 and gamma-tubulin. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}. |
| Q7Z6B7 | SRGAP1 | S1008 | ochoa | SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho GTPase-activating protein 13) | GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42. {ECO:0000269|PubMed:11672528}. |
| Q7Z6I6 | ARHGAP30 | S330 | ochoa | Rho GTPase-activating protein 30 (Rho-type GTPase-activating protein 30) | GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. {ECO:0000269|PubMed:21565175}. |
| Q7Z6I6 | ARHGAP30 | S1067 | ochoa | Rho GTPase-activating protein 30 (Rho-type GTPase-activating protein 30) | GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. {ECO:0000269|PubMed:21565175}. |
| Q7Z6Z7 | HUWE1 | S1382 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q86UX7 | FERMT3 | S345 | ochoa | Fermitin family homolog 3 (Kindlin-3) (MIG2-like protein) (Unc-112-related protein 2) | Plays a central role in cell adhesion in hematopoietic cells (PubMed:19234463, PubMed:26359933). Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3) (By similarity). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells (PubMed:19234460). Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (By similarity). {ECO:0000250|UniProtKB:Q8K1B8, ECO:0000269|PubMed:19234460, ECO:0000269|PubMed:19234463, ECO:0000269|PubMed:26359933}.; FUNCTION: Isoform 2 may act as a repressor of NF-kappa-B and apoptosis. {ECO:0000269|PubMed:19064721, ECO:0000269|PubMed:19234460, ECO:0000269|PubMed:19234463}. |
| Q86YV0 | RASAL3 | S231 | ochoa | RAS protein activator like-3 | Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down-stream ERK signaling pathway. {ECO:0000250|UniProtKB:Q8C2K5}. |
| Q8IWJ2 | GCC2 | S1490 | ochoa | GRIP and coiled-coil domain-containing protein 2 (185 kDa Golgi coiled-coil protein) (GCC185) (CLL-associated antigen KW-11) (CTCL tumor antigen se1-1) (Ran-binding protein 2-like 4) (RanBP2L4) (Renal carcinoma antigen NY-REN-53) | Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2. {ECO:0000269|PubMed:16885419, ECO:0000269|PubMed:17488291, ECO:0000269|PubMed:17543864}. |
| Q8IWU2 | LMTK2 | S672 | ochoa | Serine/threonine-protein kinase LMTK2 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase 2) (Brain-enriched kinase) (hBREK) (CDK5/p35-regulated kinase) (CPRK) (Kinase/phosphatase/inhibitor 2) (Lemur tyrosine kinase 2) (Serine/threonine-protein kinase KPI-2) | Phosphorylates PPP1C, phosphorylase b and CFTR. |
| Q8IWV7 | UBR1 | S1593 | ochoa | E3 ubiquitin-protein ligase UBR1 (EC 2.3.2.27) (N-recognin-1) (Ubiquitin-protein ligase E3-alpha-1) (Ubiquitin-protein ligase E3-alpha-I) | E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (PubMed:15548684, PubMed:16311597, PubMed:18162545, PubMed:20835242, PubMed:28392261). Recognizes and binds proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (PubMed:18162545, PubMed:20835242, PubMed:28392261). Recognizes both type-1 and type-2 N-degrons, containing positively charged amino acids (Arg, Lys and His) and bulky and hydrophobic amino acids, respectively (PubMed:18162545). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:20835242). In contrast, it strongly binds methylated N-degrons (PubMed:28392261). Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth (PubMed:20298436). {ECO:0000269|PubMed:15548684, ECO:0000269|PubMed:16311597, ECO:0000269|PubMed:18162545, ECO:0000269|PubMed:20298436, ECO:0000269|PubMed:20835242, ECO:0000269|PubMed:28392261}. |
| Q8IXL6 | FAM20C | S106 | psp | Extracellular serine/threonine protein kinase FAM20C (EC 2.7.11.1) (Dentin matrix protein 4) (DMP-4) (Golgi casein kinase) (Golgi-enriched fraction casein kinase) (GEF-CK) | Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth (PubMed:22582013, PubMed:23754375, PubMed:25789606). Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome (PubMed:26091039). Mainly phosphorylates proteins within the Ser-x-Glu/pSer motif, but also displays a broader substrate specificity (PubMed:26091039). Phosphorylates ERO1A, enhancing its activity which is required to maintain endoplasmic reticulum redox homeostasis and for oxidative protein folding (PubMed:29858230, PubMed:34349020). During endoplasmic reticulum stress, phosphorylates P4HB/PDIA1 which induces a functional switch, causing P4HB to change from an oxidoreductase to a molecular chaperone (PubMed:32149426). This is critical to maintain ER proteostasis and reduce cell death under ER stress (PubMed:32149426). Phosphorylation of P4HB also promotes its interaction with ERN1, leading to reduced activity of ERN1, a key sensor for the endoplasmic reticulum unfolded protein response (PubMed:32149426). Required for osteoblast differentiation and mineralization (PubMed:34349020). Phosphorylates casein as well as a number of proteins involved in biomineralization such as AMELX, AMTN, ENAM and SPP1/OPN (PubMed:22582013, PubMed:25789606, PubMed:34349020). In addition to its role in biomineralization, also plays a role in lipid homeostasis, wound healing and cell migration and adhesion (PubMed:26091039). {ECO:0000269|PubMed:22582013, ECO:0000269|PubMed:23754375, ECO:0000269|PubMed:25789606, ECO:0000269|PubMed:26091039, ECO:0000269|PubMed:29858230, ECO:0000269|PubMed:32149426, ECO:0000269|PubMed:34349020}. |
| Q8IY63 | AMOTL1 | S787 | ochoa | Angiomotin-like protein 1 | Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. {ECO:0000269|PubMed:22362771}. |
| Q8N1I0 | DOCK4 | S1769 | ochoa | Dedicator of cytokinesis protein 4 | Functions as a guanine nucleotide exchange factor (GEF) that promotes the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form (PubMed:12628187, PubMed:16464467). Involved in regulation of adherens junction between cells (PubMed:12628187). Plays a role in cell migration (PubMed:20679435). {ECO:0000269|PubMed:12628187, ECO:0000269|PubMed:16464467, ECO:0000269|PubMed:20679435}.; FUNCTION: [Isoform 2]: Has a higher guanine nucleotide exchange factor activity compared to other isoforms. {ECO:0000269|PubMed:16464467}. |
| Q8N3D4 | EHBP1L1 | S173 | ochoa | EH domain-binding protein 1-like protein 1 | May act as Rab effector protein and play a role in vesicle trafficking. {ECO:0000305|PubMed:27552051}. |
| Q8N3U4 | STAG2 | S1047 | ochoa | Cohesin subunit SA-2 (SCC3 homolog 2) (Stromal antigen 2) | Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. {ECO:0000269|PubMed:12034751}. |
| Q8N5K1 | CISD2 | S69 | ochoa | CDGSH iron-sulfur domain-containing protein 2 (Endoplasmic reticulum intermembrane small protein) (MitoNEET-related 1 protein) (Miner1) (Nutrient-deprivation autophagy factor-1) (NAF-1) | Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy. {ECO:0000269|PubMed:17846994, ECO:0000269|PubMed:20010695}. |
| Q8NAN2 | MIGA1 | S293 | ochoa | Mitoguardin 1 (Protein FAM73A) | Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD. {ECO:0000269|PubMed:26711011}. |
| Q8NDI1 | EHBP1 | S174 | ochoa | EH domain-binding protein 1 | May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (PubMed:14676205, PubMed:27552051). Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). {ECO:0000250|UniProtKB:Q69ZW3, ECO:0000269|PubMed:14676205, ECO:0000305|PubMed:27552051}. |
| Q8NF91 | SYNE1 | S1371 | ochoa | Nesprin-1 (Enaptin) (KASH domain-containing protein 1) (KASH1) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) | Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenesis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette. {ECO:0000250|UniProtKB:Q6ZWR6, ECO:0000269|PubMed:11792814, ECO:0000269|PubMed:18396275}. |
| Q8NG31 | KNL1 | S1008 | ochoa | Outer kinetochore KNL1 complex subunit KNL1 (ALL1-fused gene from chromosome 15q14 protein) (AF15q14) (Bub-linking kinetochore protein) (Blinkin) (Cancer susceptibility candidate gene 5 protein) (Cancer/testis antigen 29) (CT29) (Kinetochore scaffold 1) (Kinetochore-null protein 1) (Protein CASC5) (Protein D40/AF15q14) | Acts as a component of the outer kinetochore KNL1 complex that serves as a docking point for spindle assembly checkpoint components and mediates microtubule-kinetochore interactions (PubMed:15502821, PubMed:17981135, PubMed:18045986, PubMed:19893618, PubMed:21199919, PubMed:22000412, PubMed:22331848, PubMed:27881301, PubMed:30100357). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules (PubMed:18045986, PubMed:19893618, PubMed:27881301). The outer kinetochore is made up of the ten-subunit KMN network, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:38459127, PubMed:38459128). Required for kinetochore binding by a distinct subset of kMAPs (kinetochore-bound microtubule-associated proteins) and motors (PubMed:19893618). Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore (PubMed:18045986, PubMed:27881301). Can bind either to microtubules or to the protein phosphatase 1 (PP1) catalytic subunits PPP1CA and PPP1CC (via overlapping binding sites), it has higher affinity for PP1 (PubMed:30100357). Recruits MAD2L1 to the kinetochore and also directly links BUB1 and BUB1B to the kinetochore (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:22331848, PubMed:25308863). In addition to orienting mitotic chromosomes, it is also essential for alignment of homologous chromosomes during meiotic metaphase I (By similarity). In meiosis I, required to activate the spindle assembly checkpoint at unattached kinetochores to correct erroneous kinetochore-microtubule attachments (By similarity). {ECO:0000250|UniProtKB:Q66JQ7, ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:17981135, ECO:0000269|PubMed:18045986, ECO:0000269|PubMed:19893618, ECO:0000269|PubMed:21199919, ECO:0000269|PubMed:22000412, ECO:0000269|PubMed:22331848, ECO:0000269|PubMed:25308863, ECO:0000269|PubMed:27881301, ECO:0000269|PubMed:30100357, ECO:0000269|PubMed:38459127, ECO:0000269|PubMed:38459128}. |
| Q8NHQ8 | RASSF8 | S105 | ochoa | Ras association domain-containing protein 8 (Carcinoma-associated protein HOJ-1) | None |
| Q8TD26 | CHD6 | S1654 | ochoa | Chromodomain-helicase-DNA-binding protein 6 (CHD-6) (EC 3.6.4.-) (ATP-dependent helicase CHD6) (Radiation-induced gene B protein) | ATP-dependent chromatin-remodeling factor (PubMed:17027977, PubMed:28533432). Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin; nucleosome disruption requires ATP (PubMed:28533432). Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2. {ECO:0000269|PubMed:16314513, ECO:0000269|PubMed:17027977, ECO:0000269|PubMed:28533432}.; FUNCTION: (Microbial infection) Acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. {ECO:0000269|PubMed:20631145, ECO:0000269|PubMed:21899694, ECO:0000269|PubMed:23408615}. |
| Q8WWI1 | LMO7 | S895 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q8WWL2 | SPIRE2 | S371 | ochoa | Protein spire homolog 2 (Spir-2) | Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed:21620703). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning and asymmetric cell division during meiosis (PubMed:21620703). Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). {ECO:0000250|UniProtKB:Q8K1S6, ECO:0000269|PubMed:21620703, ECO:0000269|PubMed:26287480}. |
| Q92619 | ARHGAP45 | S952 | ochoa | Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1 (mHag HA-1)] | Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity. {ECO:0000269|PubMed:24086303}.; FUNCTION: Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL. {ECO:0000269|PubMed:12601144, ECO:0000269|PubMed:8260714, ECO:0000269|PubMed:8532022, ECO:0000269|PubMed:9798702}. |
| Q92622 | RUBCN | S473 | ochoa | Run domain Beclin-1-interacting and cysteine-rich domain-containing protein (Rubicon) (Beclin-1 associated RUN domain containing protein) (Baron) | Inhibits PIK3C3 activity; under basal conditions negatively regulates PI3K complex II (PI3KC3-C2) function in autophagy. Negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process. Can sequester UVRAG from association with a class C Vps complex (possibly the HOPS complex) and negatively regulates Rab7 activation (PubMed:20974968, PubMed:21062745). {ECO:0000269|PubMed:20974968, ECO:0000269|PubMed:21062745}.; FUNCTION: Involved in regulation of pathogen-specific host defense of activated macrophages. Following bacterial infection promotes NADH oxidase activity by association with CYBA thereby affecting TLR2 signaling and probably other TLR-NOX pathways. Stabilizes the CYBA:CYBB NADPH oxidase heterodimer, increases its association with TLR2 and its phagosome trafficking to induce antimicrobial burst of ROS and production of inflammatory cytokines (PubMed:22423966). Following fungal or viral infection (implicating CLEC7A (dectin-1)-mediated myeloid cell activation or RIGI-dependent sensing of RNA viruses) negatively regulates pro-inflammatory cytokine production by association with CARD9 and sequestering it from signaling complexes (PubMed:22423967). {ECO:0000269|PubMed:22423966, ECO:0000269|PubMed:22423967}. |
| Q92844 | TANK | S228 | ochoa | TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF) | Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989). Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989). May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. {ECO:0000269|PubMed:12133833, ECO:0000269|PubMed:21931631, ECO:0000269|PubMed:25861989}. |
| Q92985 | IRF7 | S477 | psp | Interferon regulatory factor 7 (IRF-7) | Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses (PubMed:28342865, PubMed:28768858). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:17574024, PubMed:32972995). Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Induces transcription of ubiquitin hydrolase USP25 mRNA in response to lipopolysaccharide (LPS) or viral infection in a type I IFN-dependent manner (By similarity). Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages (By similarity) (PubMed:11073981, PubMed:12374802, PubMed:15361868, PubMed:17404045). {ECO:0000250|UniProtKB:P70434, ECO:0000269|PubMed:11073981, ECO:0000269|PubMed:12374802, ECO:0000269|PubMed:15361868, ECO:0000269|PubMed:17404045, ECO:0000269|PubMed:17574024, ECO:0000269|PubMed:28342865, ECO:0000269|PubMed:28768858, ECO:0000269|PubMed:32972995}. |
| Q96ME7 | ZNF512 | S222 | ochoa | Zinc finger protein 512 | May be involved in transcriptional regulation. |
| Q96PE2 | ARHGEF17 | S461 | ochoa | Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}. |
| Q96RV3 | PCNX1 | S752 | ochoa | Pecanex-like protein 1 (Pecanex homolog protein 1) | None |
| Q96ST8 | CEP89 | S114 | ochoa | Centrosomal protein of 89 kDa (Cep89) (Centrosomal protein 123) (Cep123) (Coiled-coil domain-containing protein 123) | Required for ciliogenesis. Also plays a role in mitochondrial metabolism where it may modulate complex IV activity. {ECO:0000269|PubMed:23348840, ECO:0000269|PubMed:23575228}. |
| Q99708 | RBBP8 | S593 | ochoa|psp | DNA endonuclease RBBP8 (EC 3.1.-.-) (CtBP-interacting protein) (CtIP) (Retinoblastoma-binding protein 8) (RBBP-8) (Retinoblastoma-interacting protein and myosin-like) (RIM) (Sporulation in the absence of SPO11 protein 2 homolog) (SAE2) | Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway (PubMed:17965729, PubMed:19202191, PubMed:19759395, PubMed:20064462, PubMed:23273981, PubMed:26721387, PubMed:27814491, PubMed:27889449, PubMed:30787182). HR is restricted to S and G2 phases of the cell cycle and preferentially repairs DSBs resulting from replication fork collapse (PubMed:17965729, PubMed:19202191, PubMed:23273981, PubMed:27814491, PubMed:27889449, PubMed:30787182). Key determinant of DSB repair pathway choice, as it commits cells to HR by preventing classical non-homologous end-joining (NHEJ) (PubMed:19202191). Specifically promotes the endonuclease activity of the MRN complex to clear DNA ends containing protein adducts: recruited to DSBs by NBN following phosphorylation by CDK1, and promotes the endonuclease activity of MRE11 to clear protein-DNA adducts and generate clean double-strand break ends (PubMed:27814491, PubMed:27889449, PubMed:30787182, PubMed:33836577). Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA (PubMed:16581787, PubMed:17965729, PubMed:19759395, PubMed:20064462). Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage (PubMed:15485915, PubMed:16818604). During immunoglobulin heavy chain class-switch recombination, promotes microhomology-mediated alternative end joining (A-NHEJ) and plays an essential role in chromosomal translocations (By similarity). Binds preferentially to DNA Y-junctions and to DNA substrates with blocked ends and promotes intermolecular DNA bridging (PubMed:30601117). {ECO:0000250|UniProtKB:Q80YR6, ECO:0000269|PubMed:15485915, ECO:0000269|PubMed:16581787, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17965729, ECO:0000269|PubMed:19202191, ECO:0000269|PubMed:19759395, ECO:0000269|PubMed:20064462, ECO:0000269|PubMed:23273981, ECO:0000269|PubMed:26721387, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:30601117, ECO:0000269|PubMed:30787182, ECO:0000269|PubMed:33836577}. |
| Q99801 | NKX3-1 | S196 | psp | Homeobox protein Nkx-3.1 (Homeobox protein NK-3 homolog A) | Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. {ECO:0000269|PubMed:19462257}. |
| Q99983 | OMD | S234 | ochoa | Osteomodulin (Keratan sulfate proteoglycan osteomodulin) (KSPG osteomodulin) (Osteoadherin) (OSAD) | May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)-integrin. {ECO:0000250|UniProtKB:O77742}. |
| Q9BTV7 | CABLES2 | S130 | ochoa | CDK5 and ABL1 enzyme substrate 2 (Interactor with CDK3 2) (Ik3-2) | Unknown. Probably involved in G1-S cell cycle transition. |
| Q9BV23 | ABHD6 | S115 | ochoa | Monoacylglycerol lipase ABHD6 (EC 3.1.1.23) (2-arachidonoylglycerol hydrolase) (Abhydrolase domain-containing protein 6) | Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (PubMed:22969151). Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways (By similarity). Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity). Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism (PubMed:26491015). BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and plays a key role in the formation of intraluminal vesicles and in lipid sorting (PubMed:26491015). {ECO:0000250|UniProtKB:Q8R2Y0, ECO:0000269|PubMed:22969151, ECO:0000269|PubMed:26491015}. |
| Q9BXF6 | RAB11FIP5 | S251 | ochoa | Rab11 family-interacting protein 5 (Rab11-FIP5) (Gamma-SNAP-associated factor 1) (Gaf-1) (Phosphoprotein pp75) (Rab11-interacting protein Rip11) | Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis. {ECO:0000269|PubMed:11163216, ECO:0000269|PubMed:20717956}. |
| Q9BXI6 | TBC1D10A | S40 | ochoa | TBC1 domain family member 10A (EBP50-PDX interactor of 64 kDa) (EPI64 protein) (Rab27A-GAP-alpha) | GTPase-activating protein (GAP) specific for RAB27A and RAB35 (PubMed:16923811, PubMed:30905672). Does not show GAP activity for RAB2A, RAB3A and RAB4A (PubMed:16923811). {ECO:0000269|PubMed:16923811, ECO:0000269|PubMed:30905672}. |
| Q9BXS4 | TMEM59 | S295 | ochoa | Transmembrane protein 59 (Liver membrane-bound protein) | Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy (PubMed:23376921, PubMed:27273576). Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP (PubMed:20427278). Inhibits APP transport to the cell surface and further shedding (PubMed:20427278). {ECO:0000269|PubMed:20427278, ECO:0000269|PubMed:23376921, ECO:0000269|PubMed:27273576}. |
| Q9C0B5 | ZDHHC5 | S458 | ochoa | Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, GSDMD, NLRP3, NOD1, NOD2, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, inflammation, fatty acid uptake, bacterial sensing or cardiac functions (PubMed:21820437, PubMed:29185452, PubMed:31402609, PubMed:31649195, PubMed:34293401, PubMed:38092000, PubMed:38530158, PubMed:38599239). Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) (PubMed:26334723). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins (PubMed:26334723). Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2 (PubMed:26334723). Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2 (PubMed:31402609). Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes (PubMed:31649195, PubMed:34293401). Also participates in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane (PubMed:32958780). Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis (PubMed:32958780). Controls oligodendrocyte development by catalyzing STAT3 palmitoylation (By similarity). Acts as a regulator of inflammatory response by mediating palmitoylation of NLRP3 and GSDMD (PubMed:38092000, PubMed:38530158, PubMed:38599239). Palmitoylates NLRP3 to promote inflammasome assembly and activation (PubMed:38092000). Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD), thereby promoting membrane translocation and pore formation of GSDMD (PubMed:38530158, PubMed:38599239). {ECO:0000250|UniProtKB:Q8VDZ4, ECO:0000269|PubMed:21820437, ECO:0000269|PubMed:26334723, ECO:0000269|PubMed:29185452, ECO:0000269|PubMed:31402609, ECO:0000269|PubMed:31649195, ECO:0000269|PubMed:32958780, ECO:0000269|PubMed:34293401, ECO:0000269|PubMed:38092000, ECO:0000269|PubMed:38530158, ECO:0000269|PubMed:38599239}. |
| Q9C0D6 | FHDC1 | S570 | ochoa | FH2 domain-containing protein 1 (Inverted formin-1) | Microtubule-associated formin which regulates both actin and microtubule dynamics. Induces microtubule acetylation and stabilization and actin stress fiber formation (PubMed:18815276). Regulates Golgi ribbon formation (PubMed:26564798). Required for normal cilia assembly. Early in cilia assembly, may assist in the maturation and positioning of the centrosome/basal body, and once cilia assembly has initiated, may also promote cilia elongation by inhibiting disassembly (PubMed:29742020). {ECO:0000269|PubMed:18815276, ECO:0000269|PubMed:26564798, ECO:0000269|PubMed:29742020}. |
| Q9H019 | MTFR1L | S232 | ochoa | Mitochondrial fission regulator 1-like | Mitochondrial protein required for adaptation of miochondrial dynamics to metabolic changes. Regulates mitochondrial morphology at steady state and mediates AMPK-dependent stress-induced mitochondrial fragmentation via the control of OPA1 levels. {ECO:0000269|PubMed:36367943}. |
| Q9H1H9 | KIF13A | S1763 | ochoa | Kinesin-like protein KIF13A (Kinesin-like protein RBKIN) | Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR-containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abscission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis. {ECO:0000269|PubMed:19841138, ECO:0000269|PubMed:20208530}. |
| Q9H201 | EPN3 | S506 | ochoa | Epsin-3 (EPS-15-interacting protein 3) | None |
| Q9H3Q1 | CDC42EP4 | S118 | ochoa | Cdc42 effector protein 4 (Binder of Rho GTPases 4) | Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts. |
| Q9H4L5 | OSBPL3 | S304 | ochoa | Oxysterol-binding protein-related protein 3 (ORP-3) (OSBP-related protein 3) | Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology (PubMed:16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed:18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 (PubMed:16143324). Also binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:18270267, ECO:0000269|PubMed:25447204}. |
| Q9H583 | HEATR1 | S19 | ochoa | HEAT repeat-containing protein 1 (Protein BAP28) (U3 small nucleolar RNA-associated protein 10 homolog) [Cleaved into: HEAT repeat-containing protein 1, N-terminally processed] | Ribosome biogenesis factor; required for recruitment of Myc to nucleoli (PubMed:38225354). Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I (PubMed:17699751). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Involved in neuronal-lineage cell proliferation (PubMed:38225354). {ECO:0000269|PubMed:17699751, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:38225354}. |
| Q9H792 | PEAK1 | S1237 | ochoa | Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269) | Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:20534451, PubMed:23105102, PubMed:35687021). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654). {ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:23105102, ECO:0000269|PubMed:23846654, ECO:0000269|PubMed:35687021}. |
| Q9H8Y8 | GORASP2 | S214 | ochoa | Golgi reassembly-stacking protein 2 (GRS2) (Golgi phosphoprotein 6) (GOLPH6) (Golgi reassembly-stacking protein of 55 kDa) (GRASP55) (p59) | Key structural protein of the Golgi apparatus (PubMed:33301566). The membrane cisternae of the Golgi apparatus adhere to each other to form stacks, which are aligned side by side to form the Golgi ribbon (PubMed:33301566). Acting in concert with GORASP1/GRASP65, is required for the formation and maintenance of the Golgi ribbon, and may be dispensable for the formation of stacks (PubMed:33301566). However, other studies suggest that GORASP2 plays a role in the assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after breakdown during mitosis and meiosis (PubMed:10487747, PubMed:21515684, PubMed:22523075). May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane TGFA (PubMed:11101516). Required for normal acrosome formation during spermiogenesis and normal male fertility, probably by promoting colocalization of JAM2 and JAM3 at contact sites between germ cells and Sertoli cells (By similarity). Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (PubMed:21884936, PubMed:27062250, PubMed:28067262). {ECO:0000250|UniProtKB:Q99JX3, ECO:0000269|PubMed:10487747, ECO:0000269|PubMed:11101516, ECO:0000269|PubMed:21515684, ECO:0000269|PubMed:21884936, ECO:0000269|PubMed:22523075, ECO:0000269|PubMed:27062250, ECO:0000269|PubMed:28067262}. |
| Q9HAC8 | UBTD1 | S166 | ochoa | Ubiquitin domain-containing protein 1 | May be involved in the regulation of cellular senescence through a positive feedback loop with TP53. Is a TP53 downstream target gene that increases the stability of TP53 protein by promoting the ubiquitination and degradation of MDM2. {ECO:0000269|PubMed:25382750}. |
| Q9HCE1 | MOV10 | Y980 | ochoa | Helicase MOV-10 (EC 3.6.4.13) (Armitage homolog) (Moloney leukemia virus 10 protein) | 5' to 3' RNA helicase that is involved in a number of cellular roles ranging from mRNA metabolism and translation, modulation of viral infectivity, inhibition of retrotransposition, or regulation of synaptic transmission (PubMed:23093941). Plays an important role in innate antiviral immunity by promoting type I interferon production (PubMed:27016603, PubMed:27974568, PubMed:35157734). Mechanistically, specifically uses IKKepsilon/IKBKE as the mediator kinase for IRF3 activation (PubMed:27016603, PubMed:35157734). Blocks HIV-1 virus replication at a post-entry step (PubMed:20215113). Counteracts HIV-1 Vif-mediated degradation of APOBEC3G through its helicase activity by interfering with the ubiquitin-proteasome pathway (PubMed:29258557). Also inhibits hepatitis B virus/HBV replication by interacting with HBV RNA and thereby inhibiting the early step of viral reverse transcription (PubMed:31722967). Contributes to UPF1 mRNA target degradation by translocation along 3' UTRs (PubMed:24726324). Required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:16289642, PubMed:17507929, PubMed:22791714). In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2 (PubMed:25464849). Restricts retrotransposition of long interspersed element-1 (LINE-1) in cooperation with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1 (PubMed:23093941, PubMed:30122351). Facilitates LINE-1 uridylation by TUT4 and TUT7 (PubMed:30122351). Required for embryonic viability and for normal central nervous system development and function. Plays two critical roles in early brain development: suppresses retroelements in the nucleus by directly inhibiting cDNA synthesis, while regulates cytoskeletal mRNAs to influence neurite outgrowth in the cytosol (By similarity). May function as a messenger ribonucleoprotein (mRNP) clearance factor (PubMed:24726324). {ECO:0000250|UniProtKB:P23249, ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:17507929, ECO:0000269|PubMed:20215113, ECO:0000269|PubMed:22791714, ECO:0000269|PubMed:23093941, ECO:0000269|PubMed:24726324, ECO:0000269|PubMed:25464849, ECO:0000269|PubMed:27016603, ECO:0000269|PubMed:27974568, ECO:0000269|PubMed:29258557, ECO:0000269|PubMed:30122351, ECO:0000269|PubMed:31722967, ECO:0000269|PubMed:35157734}.; FUNCTION: (Microbial infection) Required for RNA-directed transcription and replication of the human hepatitis delta virus (HDV). Interacts with small capped HDV RNAs derived from genomic hairpin structures that mark the initiation sites of RNA-dependent HDV RNA transcription. {ECO:0000269|PubMed:18552826}. |
| Q9HCN3 | PGAP6 | S403 | ochoa | Post-GPI attachment to proteins factor 6 (EC 3.1.1.4) (GPI processing phospholipase A2) (GPI-PLA2) (Protein M83) (Transmembrane protein 6) (Transmembrane protein 8) (Transmembrane protein 8A) | Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchor proteins (GPI-AP). Has phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI. Required for the shedding of the GPI-AP CRIPTO, but not CFC1, at the cell surface. Shedding of CRIPTO modulates Nodal signaling by allowing soluble CRIPTO to act as a Nodal coreceptor on other cells (PubMed:27881714). Also indirectly involved in the translocation of RAC1 from the cytosol to the plasma membrane by maintaining the steady state amount of CAV1-enriched plasma membrane subdomains, stabilizing RAC1 at the plasma membrane (PubMed:27835684). In contrast to myomaker (TMEM8C), has no fusogenic activity (PubMed:26858401). {ECO:0000269|PubMed:26858401, ECO:0000269|PubMed:27835684, ECO:0000269|PubMed:27881714}. |
| Q9NQW7 | XPNPEP1 | S556 | ochoa | Xaa-Pro aminopeptidase 1 (EC 3.4.11.9) (Aminoacylproline aminopeptidase) (Cytosolic aminopeptidase P) (Soluble aminopeptidase P) (sAmp) (X-Pro aminopeptidase 1) (X-prolyl aminopeptidase 1, soluble) | Metalloaminopeptidase that catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro (PubMed:11106490, PubMed:18515364, PubMed:35165443). Contributes to the degradation of bradykinin (PubMed:11106490). {ECO:0000269|PubMed:11106490, ECO:0000269|PubMed:18515364, ECO:0000269|PubMed:35165443}. |
| Q9NRX5 | SERINC1 | S364 | ochoa | Serine incorporator 1 (Tumor differentially expressed protein 1-like) (Tumor differentially expressed protein 2) | Enhances the incorporation of serine into phosphatidylserine and sphingolipids. {ECO:0000250|UniProtKB:Q7TNK0}. |
| Q9NSY1 | BMP2K | S1064 | ochoa | BMP-2-inducible protein kinase (BIKe) (EC 2.7.11.1) | May be involved in osteoblast differentiation. {ECO:0000250|UniProtKB:Q91Z96}. |
| Q9NXR8 | ING3 | S123 | ochoa | Inhibitor of growth protein 3 (p47ING3) | Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. {ECO:0000269|PubMed:12545155, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}. |
| Q9NYA4 | MTMR4 | S601 | ochoa | Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4 (EC 3.1.3.95) (FYVE domain-containing dual specificity protein phosphatase 2) (FYVE-DSP2) (Myotubularin-related protein 4) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (Zinc finger FYVE domain-containing protein 11) | Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate (PubMed:11302699, PubMed:16787938, PubMed:20736309, PubMed:27625994, PubMed:29962048, PubMed:30944173). Decreases the levels of phosphatidylinositol 3-phosphate, a phospholipid found in cell membranes where it acts as key regulator of both cell signaling and intracellular membrane traffic, in a subset of endosomal membranes to negatively regulate both endocytic recycling and trafficking and/or maturation of endosomes toward lysosomes (PubMed:16787938, PubMed:20736309, PubMed:29962048). Through phosphatidylinositol 3-phosphate turnover in phagosome membranes regulates phagocytosis and phagosome maturation (PubMed:31543504). By decreasing phosphatidylinositol 3-monophosphate (PI3P) levels in immune cells it can also regulate the innate immune response (PubMed:30944173). Beside its lipid phosphatase activity, can also function as a molecular adapter to regulate midbody abscission during mitotic cytokinesis (PubMed:25659891). Can also negatively regulate TGF-beta and BMP signaling through Smad proteins dephosphorylation and retention in endosomes (PubMed:20061380, PubMed:23150675). {ECO:0000269|PubMed:11302699, ECO:0000269|PubMed:16787938, ECO:0000269|PubMed:20061380, ECO:0000269|PubMed:20736309, ECO:0000269|PubMed:23150675, ECO:0000269|PubMed:25659891, ECO:0000269|PubMed:27625994, ECO:0000269|PubMed:29962048, ECO:0000269|PubMed:30944173, ECO:0000269|PubMed:31543504}. |
| Q9NYL2 | MAP3K20 | S366 | ochoa | Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase 7) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) | Stress-activated component of a protein kinase signal transduction cascade that promotes programmed cell death in response to various stress, such as ribosomal stress, osmotic shock and ionizing radiation (PubMed:10924358, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15350844, PubMed:15737997, PubMed:18331592, PubMed:20559024, PubMed:26999302, PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts by catalyzing phosphorylation of MAP kinase kinases, leading to activation of the JNK (MAPK8/JNK1, MAPK9/JNK2 and/or MAPK10/JNK3) and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11042189, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15172994, PubMed:15737997, PubMed:32289254, PubMed:32610081, PubMed:35857590). Activates JNK through phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7, and MAP kinase p38 gamma (MAPK12) via phosphorylation of MAP2K3/MKK3 and MAP2K6/MKK6 (PubMed:11836244, PubMed:12220515). Involved in stress associated with adrenergic stimulation: contributes to cardiac decompensation during periods of acute cardiac stress (PubMed:15350844, PubMed:21224381, PubMed:27859413). May be involved in regulation of S and G2 cell cycle checkpoint by mediating phosphorylation of CHEK2 (PubMed:15342622). {ECO:0000269|PubMed:10924358, ECO:0000269|PubMed:11042189, ECO:0000269|PubMed:11836244, ECO:0000269|PubMed:12220515, ECO:0000269|PubMed:14521931, ECO:0000269|PubMed:15172994, ECO:0000269|PubMed:15342622, ECO:0000269|PubMed:15350844, ECO:0000269|PubMed:15737997, ECO:0000269|PubMed:18331592, ECO:0000269|PubMed:20559024, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:26999302, ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKalpha]: Key component of the stress-activated protein kinase signaling cascade in response to ribotoxic stress or UV-B irradiation (PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts as the proximal sensor of ribosome collisions during the ribotoxic stress response (RSR): directly binds to the ribosome by inserting its flexible C-terminus into the ribosomal intersubunit space, thereby acting as a sentinel for colliding ribosomes (PubMed:32289254, PubMed:32610081). Upon ribosome collisions, activates either the stress-activated protein kinase signal transduction cascade or the integrated stress response (ISR), leading to programmed cell death or cell survival, respectively (PubMed:32610081). Dangerous levels of ribosome collisions trigger the autophosphorylation and activation of MAP3K20, which dissociates from colliding ribosomes and phosphorylates MAP kinase kinases, leading to activation of the JNK and MAP kinase p38 pathways that promote programmed cell death (PubMed:32289254, PubMed:32610081). Less dangerous levels of ribosome collisions trigger the integrated stress response (ISR): MAP3K20 activates EIF2AK4/GCN2 independently of its protein-kinase activity, promoting EIF2AK4/GCN2-mediated phosphorylation of EIF2S1/eIF-2-alpha (PubMed:32610081). Also part of the stress-activated protein kinase signaling cascade triggering the NLRP1 inflammasome in response to UV-B irradiation: ribosome collisions activate MAP3K20, which directly phosphorylates NLRP1, leading to activation of the NLRP1 inflammasome and subsequent pyroptosis (PubMed:35857590). NLRP1 is also phosphorylated by MAP kinase p38 downstream of MAP3K20 (PubMed:35857590). Also acts as a histone kinase by phosphorylating histone H3 at 'Ser-28' (H3S28ph) (PubMed:15684425). {ECO:0000269|PubMed:15684425, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKbeta]: Isoform that lacks the C-terminal region that mediates ribosome-binding: does not act as a sensor of ribosome collisions in response to ribotoxic stress (PubMed:32289254, PubMed:32610081, PubMed:35857590). May act as an antagonist of isoform ZAKalpha: interacts with isoform ZAKalpha, leading to decrease the expression of isoform ZAKalpha (PubMed:27859413). {ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}. |
| Q9NZI8 | IGF2BP1 | S314 | ochoa | Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2 mRNA-binding protein 1) (IMP-1) (IMP1) (Coding region determinant-binding protein) (CRD-BP) (IGF-II mRNA-binding protein 1) (VICKZ family member 1) (Zipcode-binding protein 1) (ZBP-1) | RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (PubMed:29476152, PubMed:32245947). Plays a direct role in the transport and translation of transcripts required for axonal regeneration in adult sensory neurons (By similarity). Regulates localized beta-actin/ACTB mRNA translation, a crucial process for cell polarity, cell migration and neurite outgrowth. Co-transcriptionally associates with the ACTB mRNA in the nucleus. This binding involves a conserved 54-nucleotide element in the ACTB mRNA 3'-UTR, known as the 'zipcode'. The RNP thus formed is exported to the cytoplasm, binds to a motor protein and is transported along the cytoskeleton to the cell periphery. During transport, prevents ACTB mRNA from being translated into protein. When the RNP complex reaches its destination near the plasma membrane, IGF2BP1 is phosphorylated. This releases the mRNA, allowing ribosomal 40S and 60S subunits to assemble and initiate ACTB protein synthesis. Monomeric ACTB then assembles into the subcortical actin cytoskeleton (By similarity). During neuronal development, key regulator of neurite outgrowth, growth cone guidance and neuronal cell migration, presumably through the spatiotemporal fine tuning of protein synthesis, such as that of ACTB (By similarity). May regulate mRNA transport to activated synapses (By similarity). Binds to and stabilizes ABCB1/MDR-1 mRNA (By similarity). During interstinal wound repair, interacts with and stabilizes PTGS2 transcript. PTGS2 mRNA stabilization may be crucial for colonic mucosal wound healing (By similarity). Binds to the 3'-UTR of IGF2 mRNA by a mechanism of cooperative and sequential dimerization and regulates IGF2 mRNA subcellular localization and translation. Binds to MYC mRNA, in the coding region instability determinant (CRD) of the open reading frame (ORF), hence preventing MYC cleavage by endonucleases and possibly microRNA targeting to MYC-CRD (PubMed:29476152). Binding to MYC mRNA is enhanced by m6A-modification of the CRD (PubMed:29476152). Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to the oncofetal H19 transcript and to the neuron-specific TAU mRNA and regulates their localizations. Binds to and stabilizes BTRC/FBW1A mRNA. Binds to the adenine-rich autoregulatory sequence (ARS) located in PABPC1 mRNA and represses its translation. PABPC1 mRNA-binding is stimulated by PABPC1 protein. Prevents BTRC/FBW1A mRNA degradation by disrupting microRNA-dependent interaction with AGO2. Promotes the directed movement of tumor-derived cells by fine-tuning intracellular signaling networks. Binds to MAPK4 3'-UTR and inhibits its translation. Interacts with PTEN transcript open reading frame (ORF) and prevents mRNA decay. This combined action on MAPK4 (down-regulation) and PTEN (up-regulation) antagonizes HSPB1 phosphorylation, consequently it prevents G-actin sequestration by phosphorylated HSPB1, allowing F-actin polymerization. Hence enhances the velocity of cell migration and stimulates directed cell migration by PTEN-modulated polarization. Interacts with Hepatitis C virus (HCV) 5'-UTR and 3'-UTR and specifically enhances translation at the HCV IRES, but not 5'-cap-dependent translation, possibly by recruiting eIF3. Interacts with HIV-1 GAG protein and blocks the formation of infectious HIV-1 particles. Reduces HIV-1 assembly by inhibiting viral RNA packaging, as well as assembly and processing of GAG protein on cellular membranes. During cellular stress, such as oxidative stress or heat shock, stabilizes target mRNAs that are recruited to stress granules, including CD44, IGF2, MAPK4, MYC, PTEN, RAPGEF2 and RPS6KA5 transcripts. {ECO:0000250, ECO:0000269|PubMed:10875929, ECO:0000269|PubMed:16356927, ECO:0000269|PubMed:16541107, ECO:0000269|PubMed:16778892, ECO:0000269|PubMed:17101699, ECO:0000269|PubMed:17255263, ECO:0000269|PubMed:17893325, ECO:0000269|PubMed:18385235, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:19541769, ECO:0000269|PubMed:19647520, ECO:0000269|PubMed:20080952, ECO:0000269|PubMed:22279049, ECO:0000269|PubMed:29476152, ECO:0000269|PubMed:32245947, ECO:0000269|PubMed:8132663, ECO:0000269|PubMed:9891060}. |
| Q9NZJ9 | NUDT4 | S158 | ochoa | Diphosphoinositol polyphosphate phosphohydrolase 2 (DIPP-2) (EC 3.6.1.52) (Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 2) (EC 3.6.1.61) (Nucleoside diphosphate-linked moiety X motif 4) (Nudix motif 4) | Cleaves the beta-phosphate from diphosphoinositol polyphosphates such as PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 (diphosphoinositol tetrakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction (PubMed:10777568). Diadenosine polyphosphates, particularly Ap6A (P(1),P(6)-bis(5a-adenosyl) hexaphosphate) and Ap5A (P(1),P(5)-bis(5'-adenosyl) pentaphosphate) are downstream effectors of a signaling cascade that regulates cardiac KATP channels, can also be substrates, although with lower preference than the diphosphoinositol polyphosphates (PubMed:10777568). Can also catalyze the hydrolysis of 5-phosphoribose 1-diphosphate, generating the glycolytic activator ribose 1,5-bisphosphate (PubMed:12370170). Does not play a role in U8 snoRNA decapping activity (By similarity). Binds U8 snoRNA (By similarity). {ECO:0000250|UniProtKB:Q8R2U6, ECO:0000269|PubMed:10777568, ECO:0000269|PubMed:12370170}. |
| Q9P1T7 | MDFIC | S138 | ochoa | MyoD family inhibitor domain-containing protein (I-mfa domain-containing protein) (hIC) | Required to control the activity of various transcription factors through their sequestration in the cytoplasm. Retains nuclear Zic proteins ZIC1, ZIC2 and ZIC3 in the cytoplasm and inhibits their transcriptional activation (By similarity). Modulates the expression from cellular promoters. Binds to the axin complex, resulting in an increase in the level of free beta-catenin (PubMed:12192039). Affects axin regulation of the WNT and JNK signaling pathways (PubMed:12192039). Involved in the development of lymphatic vessel valves (By similarity). Required to promote lymphatic endothelial cell migration, in a process that involves down-regulation of integrin beta 1 activation and control of cell adhesion to the extracellular matrix (PubMed:35235341). Regulates the activity of mechanosensitive Piezo channel (PubMed:37590348). {ECO:0000250|UniProtKB:Q8BX65, ECO:0000269|PubMed:12192039, ECO:0000269|PubMed:35235341, ECO:0000269|PubMed:37590348}.; FUNCTION: (Microbial infection) Modulates the expression from viral promoters. Down-regulates Tat-dependent transcription of the human immunodeficiency virus type 1 (HIV-1) LTR by interacting with HIV-1 Tat and Rev and impairing their nuclear import, probably by rendering the NLS domains inaccessible to importin-beta (PubMed:12944466, PubMed:16260749, Ref.6). Also stimulates activation of human T-cell leukemia virus type I (HTLV-I) LTR (PubMed:10671520). {ECO:0000269|PubMed:10671520, ECO:0000269|PubMed:12944466, ECO:0000269|PubMed:16260749, ECO:0000269|Ref.6}. |
| Q9UHC7 | MKRN1 | S127 | ochoa | E3 ubiquitin-protein ligase makorin-1 (EC 2.3.2.27) (RING finger protein 61) (RING-type E3 ubiquitin transferase makorin-1) | E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription. {ECO:0000269|PubMed:16785614, ECO:0000269|PubMed:19536131}. |
| Q9UHF7 | TRPS1 | S365 | ochoa | Zinc finger transcription factor Trps1 (Tricho-rhino-phalangeal syndrome type I protein) (Zinc finger protein GC79) | Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes. {ECO:0000269|PubMed:12885770, ECO:0000269|PubMed:17391059}. |
| Q9UJF2 | RASAL2 | S803 | ochoa | Ras GTPase-activating protein nGAP (RAS protein activator-like 2) | Inhibitory regulator of the Ras-cyclic AMP pathway. |
| Q9UJF2 | RASAL2 | S893 | ochoa | Ras GTPase-activating protein nGAP (RAS protein activator-like 2) | Inhibitory regulator of the Ras-cyclic AMP pathway. |
| Q9ULH0 | KIDINS220 | S1631 | ochoa | Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) | Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. {ECO:0000250, ECO:0000269|PubMed:18089783}. |
| Q9ULL8 | SHROOM4 | S1020 | ochoa | Protein Shroom4 (Second homolog of apical protein) | Probable regulator of cytoskeletal architecture that plays an important role in development. May regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II (By similarity). {ECO:0000250, ECO:0000269|PubMed:16684770}. |
| Q9UP65 | PLA2G4C | S337 | ochoa | Cytosolic phospholipase A2 gamma (cPLA2-gamma) (EC 3.1.1.4) (Cytosolic lysophospholipase) (EC 3.1.1.5) (Cytosolic lysophospholipid O-acyltransferase) (EC 2.3.1.-) (Phospholipase A2 group IVC) | Calcium-independent phospholipase, lysophospholipase and O-acyltransferase involved in phospholipid remodeling with implications in endoplasmic reticulum membrane homeostasis and lipid droplet biogenesis (PubMed:10085124, PubMed:10358058, PubMed:19501189, PubMed:28336330, PubMed:9705332). Preferentially hydrolyzes the ester bond of the fatty acyl group attached at the sn-2 position of phospholipids with choline and ethanolamine head groups, producing lysophospholipids that are used in deacylation-reacylation cycles (PubMed:10085124, PubMed:10358058, PubMed:19501189, PubMed:28336330, PubMed:9705332). Transfers the sn-1 fatty acyl from one lysophospholipid molecule to the sn-2 position of another lysophospholipid to form diacyl, alkylacyl and alkenylacyl glycerophospholipids. Cleaves ester bonds but not alkyl or alkenyl ether bonds at sn-1 position of lysophospholipids (PubMed:15944408, PubMed:19501189). Catalyzes sn-2 fatty acyl transfer from phospholipids to the sn-2 position of 1-O-alkyl or 1-O-alkenyl lysophospholipids with lower efficiency (PubMed:15944408, PubMed:19501189). In response to dietary fatty acids, may play a role in the formation of nascent lipid droplets from the endoplasmic reticulum likely by regulating the phospholipid composition of these organelles (PubMed:28336330). {ECO:0000269|PubMed:10085124, ECO:0000269|PubMed:10358058, ECO:0000269|PubMed:15944408, ECO:0000269|PubMed:19501189, ECO:0000269|PubMed:28336330, ECO:0000269|PubMed:9705332}.; FUNCTION: (Microbial infection) May play a role in replication and assembly of human hepatitis C virus (HCV) (PubMed:23015700, PubMed:28336330). In response to HCV infection, promotes remodeling of host endoplasmic reticulum membranes to form organelle-like structures called membranous web, where HCV replication occur (PubMed:23015700). Can further mediate translocation of replication complexes to lipid droplets to enable virion assembly (PubMed:23015700, PubMed:28336330). {ECO:0000269|PubMed:23015700, ECO:0000269|PubMed:28336330}.; FUNCTION: (Microbial infection) May facilitate human T-lymphotropic virus type 1 (HTLV-1) infection by promoting leukotriene B4 (LTB4) biosynthesis. LTB4 acts as a chemoattractant for HTLV-1-infected CD4-positive T cells and favors cell to cell viral transmission. {ECO:0000269|PubMed:28639618}. |
| Q9UPN3 | MACF1 | S820 | ochoa | Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) | [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250|UniProtKB:Q9QXZ0, ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:27693509}. |
| Q9Y250 | LZTS1 | S181 | ochoa | Leucine zipper putative tumor suppressor 1 (F37/esophageal cancer-related gene-coding leucine-zipper motif) (Fez1) | Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor. {ECO:0000269|PubMed:10097140, ECO:0000269|PubMed:11464283, ECO:0000269|PubMed:11504921}. |
| Q9Y2H0 | DLGAP4 | S732 | ochoa | Disks large-associated protein 4 (DAP-4) (PSD-95/SAP90-binding protein 4) (SAP90/PSD-95-associated protein 4) (SAPAP-4) | May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane. |
| Q9Y2H2 | INPP5F | S668 | ochoa | Phosphatidylinositide phosphatase SAC2 (EC 3.1.3.25) (Inositol polyphosphate 5-phosphatase F) (Sac domain-containing inositol phosphatase 2) (Sac domain-containing phosphoinositide 4-phosphatase 2) (hSAC2) | Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling (PubMed:25869669). Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms (PubMed:25869669). Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation (PubMed:17322895). Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus (PubMed:25476455). Functionally important modulator of cardiac myocyte size and of the cardiac response to stress (By similarity). May play a role as negative regulator of axon regeneration after central nervous system injuries (By similarity). {ECO:0000250|UniProtKB:Q8CDA1, ECO:0000269|PubMed:17322895, ECO:0000269|PubMed:25476455, ECO:0000269|PubMed:25869669}. |
| Q9Y365 | STARD10 | S259 | ochoa|psp | START domain-containing protein 10 (StARD10) (Antigen NY-CO-28) (PCTP-like protein) (PCTP-L) (Serologically defined colon cancer antigen 28) (StAR-related lipid transfer protein 10) | May play metabolic roles in sperm maturation or fertilization (By similarity). Phospholipid transfer protein that preferentially selects lipid species containing a palmitoyl or stearoyl chain on the sn-1 and an unsaturated fatty acyl chain (18:1 or 18:2) on the sn-2 position. Able to transfer phosphatidylcholine (PC) and phosphatidyetanolamline (PE) between membranes. {ECO:0000250, ECO:0000269|PubMed:15911624}. |
| Q9Y446 | PKP3 | S180 | ochoa | Plakophilin-3 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:24124604). Required for the localization of DSG2, DSP and PKP2 to mature desmosome junctions (PubMed:20859650). May also play a role in the maintenance of DSG3 protein abundance in keratinocytes (By similarity). Required for the formation of DSP-containing desmosome precursors in the cytoplasm during desmosome assembly (PubMed:25208567). Also regulates the accumulation of CDH1 to mature desmosome junctions, via cAMP-dependent signaling and its interaction with activated RAP1A (PubMed:25208567). Positively regulates the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with FXR1, may also regulate the protein abundance of DSP via the same mechanism (PubMed:25225333). May also regulate the protein abundance of the desmosome component PKP1 (By similarity). Required for the organization of desmosome junctions at intercellular borders between basal keratinocytes of the epidermis, as a result plays a role in maintenance of the dermal barrier and regulation of the dermal inflammatory response (By similarity). Required during epidermal keratinocyte differentiation for cell adherence at tricellular cell-cell contacts, via regulation of the timely formation of adherens junctions and desmosomes in a calcium-dependent manner, and may also play a role in the organization of the intracellular actin fiber belt (By similarity). Acts as a negative regulator of the inflammatory response in hematopoietic cells of the skin and intestine, via modulation of proinflammatory cytokine production (By similarity). Important for epithelial barrier maintenance in the intestine to reduce intestinal permeability, thereby plays a role in protection from intestinal-derived endotoxemia (By similarity). Required for the development of hair follicles, via a role in the regulation of inner root sheaf length, correct alignment and anterior-posterior polarity of hair follicles (By similarity). Promotes proliferation and cell-cycle G1/S phase transition of keratinocytes (By similarity). Promotes E2F1-driven transcription of G1/S phase promoting genes by acting to release E2F1 from its inhibitory interaction with RB1, via sequestering RB1 and CDKN1A to the cytoplasm and thereby increasing CDK4- and CDK6-driven phosphorylation of RB1 (By similarity). May act as a scaffold protein to facilitate MAPK phosphorylation of RPS6KA protein family members and subsequently promote downstream EGFR signaling (By similarity). May play a role in the positive regulation of transcription of Wnt-mediated TCF-responsive target genes (PubMed:34058472). {ECO:0000250|UniProtKB:Q9QY23, ECO:0000269|PubMed:20859650, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:34058472}. |
| Q9Y446 | PKP3 | S196 | ochoa | Plakophilin-3 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:24124604). Required for the localization of DSG2, DSP and PKP2 to mature desmosome junctions (PubMed:20859650). May also play a role in the maintenance of DSG3 protein abundance in keratinocytes (By similarity). Required for the formation of DSP-containing desmosome precursors in the cytoplasm during desmosome assembly (PubMed:25208567). Also regulates the accumulation of CDH1 to mature desmosome junctions, via cAMP-dependent signaling and its interaction with activated RAP1A (PubMed:25208567). Positively regulates the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with FXR1, may also regulate the protein abundance of DSP via the same mechanism (PubMed:25225333). May also regulate the protein abundance of the desmosome component PKP1 (By similarity). Required for the organization of desmosome junctions at intercellular borders between basal keratinocytes of the epidermis, as a result plays a role in maintenance of the dermal barrier and regulation of the dermal inflammatory response (By similarity). Required during epidermal keratinocyte differentiation for cell adherence at tricellular cell-cell contacts, via regulation of the timely formation of adherens junctions and desmosomes in a calcium-dependent manner, and may also play a role in the organization of the intracellular actin fiber belt (By similarity). Acts as a negative regulator of the inflammatory response in hematopoietic cells of the skin and intestine, via modulation of proinflammatory cytokine production (By similarity). Important for epithelial barrier maintenance in the intestine to reduce intestinal permeability, thereby plays a role in protection from intestinal-derived endotoxemia (By similarity). Required for the development of hair follicles, via a role in the regulation of inner root sheaf length, correct alignment and anterior-posterior polarity of hair follicles (By similarity). Promotes proliferation and cell-cycle G1/S phase transition of keratinocytes (By similarity). Promotes E2F1-driven transcription of G1/S phase promoting genes by acting to release E2F1 from its inhibitory interaction with RB1, via sequestering RB1 and CDKN1A to the cytoplasm and thereby increasing CDK4- and CDK6-driven phosphorylation of RB1 (By similarity). May act as a scaffold protein to facilitate MAPK phosphorylation of RPS6KA protein family members and subsequently promote downstream EGFR signaling (By similarity). May play a role in the positive regulation of transcription of Wnt-mediated TCF-responsive target genes (PubMed:34058472). {ECO:0000250|UniProtKB:Q9QY23, ECO:0000269|PubMed:20859650, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:34058472}. |
| Q9Y490 | TLN1 | S2338 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| Q9Y4H2 | IRS2 | S346 | ochoa|psp | Insulin receptor substrate 2 (IRS-2) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}. |
| Q9Y6M1 | IGF2BP2 | S312 | ochoa | Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2 mRNA-binding protein 2) (IMP-2) (Hepatocellular carcinoma autoantigen p62) (IGF-II mRNA-binding protein 2) (VICKZ family member 2) | RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (PubMed:29476152). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs (PubMed:9891060). Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts. Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD (PubMed:29476152). {ECO:0000250, ECO:0000269|PubMed:23640942, ECO:0000269|PubMed:29476152, ECO:0000269|PubMed:9891060}. |
| Q9Y6Q2 | STON1 | S244 | ochoa | Stonin-1 (Stoned B-like factor) | May be involved in the endocytic machinery. {ECO:0000250}. |
| Q9Y6Q9 | NCOA3 | S636 | ochoa | Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. |
| Q9Y6Q9 | NCOA3 | S1033 | ochoa|psp | Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. |
| Q9Y6R1 | SLC4A4 | S223 | ochoa | Electrogenic sodium bicarbonate cotransporter 1 (Sodium bicarbonate cotransporter) (Na(+)/HCO3(-) cotransporter) (Solute carrier family 4 member 4) (kNBC1) | Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. {ECO:0000269|PubMed:10069984, ECO:0000269|PubMed:11744745, ECO:0000269|PubMed:12411514, ECO:0000269|PubMed:12730338, ECO:0000269|PubMed:12907161, ECO:0000269|PubMed:14567693, ECO:0000269|PubMed:15218065, ECO:0000269|PubMed:15713912, ECO:0000269|PubMed:15817634, ECO:0000269|PubMed:15930088, ECO:0000269|PubMed:16636648, ECO:0000269|PubMed:16769890, ECO:0000269|PubMed:17661077, ECO:0000269|PubMed:23324180, ECO:0000269|PubMed:23636456, ECO:0000269|PubMed:29500354, ECO:0000269|PubMed:9235899, ECO:0000269|PubMed:9651366}. |
| P10809 | HSPD1 | S453 | Sugiyama | 60 kDa heat shock protein, mitochondrial (EC 5.6.1.7) (60 kDa chaperonin) (Chaperonin 60) (CPN60) (Heat shock protein 60) (HSP-60) (Hsp60) (Heat shock protein family D member 1) (HuCHA60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) | Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:11422376, PubMed:1346131). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). {ECO:0000269|PubMed:11422376, ECO:0000269|PubMed:1346131, ECO:0000305|PubMed:25918392}. |
| P08195 | SLC3A2 | S292 | Sugiyama | Amino acid transporter heavy chain SLC3A2 (4F2 cell-surface antigen heavy chain) (4F2hc) (4F2 heavy chain antigen) (Lymphocyte activation antigen 4F2 large subunit) (Solute carrier family 3 member 2) (CD antigen CD98) | Acts as a chaperone that facilitates biogenesis and trafficking of functional transporters heterodimers to the plasma membrane. Forms heterodimer with SLC7 family transporters (SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A10 and SLC7A11), a group of amino-acid antiporters (PubMed:10574970, PubMed:10903140, PubMed:11557028, PubMed:30867591, PubMed:33298890, PubMed:33758168, PubMed:34880232, PubMed:9751058, PubMed:9829974, PubMed:9878049). Heterodimers function as amino acids exchangers, the specificity of the substrate depending on the SLC7A subunit. Heterodimers SLC3A2/SLC7A6 or SLC3A2/SLC7A7 mediate the uptake of dibasic amino acids (PubMed:10903140, PubMed:9829974). Heterodimer SLC3A2/SLC7A11 functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane (PubMed:34880232). SLC3A2/SLC7A10 translocates small neutral L- and D-amino acids across the plasma membrane (By similarity). SLC3A2/SLC75 or SLC3A2/SLC7A8 translocates neutral amino acids with broad specificity, thyroid hormones and L-DOPA (PubMed:10574970, PubMed:11389679, PubMed:11557028, PubMed:11564694, PubMed:11742812, PubMed:12117417, PubMed:12225859, PubMed:12716892, PubMed:15980244, PubMed:30867591, PubMed:33298890, PubMed:33758168). SLC3A2 is essential for plasma membrane localization, stability, and the transport activity of SLC7A5 and SLC7A8 (PubMed:10391915, PubMed:10574970, PubMed:11311135, PubMed:15769744, PubMed:33066406). When associated with LAPTM4B, the heterodimer SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation (PubMed:25998567). Modulates integrin-related signaling and is essential for integrin-dependent cell spreading, migration and tumor progression (PubMed:11121428, PubMed:15625115). {ECO:0000250|UniProtKB:P63115, ECO:0000269|PubMed:10391915, ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:10903140, ECO:0000269|PubMed:11121428, ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:11389679, ECO:0000269|PubMed:11557028, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:11742812, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:12716892, ECO:0000269|PubMed:15625115, ECO:0000269|PubMed:15769744, ECO:0000269|PubMed:15980244, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:33066406, ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:33758168, ECO:0000269|PubMed:34880232, ECO:0000269|PubMed:9751058, ECO:0000269|PubMed:9829974, ECO:0000269|PubMed:9878049}.; FUNCTION: (Microbial infection) In case of hepatitis C virus/HCV infection, the complex formed by SLC3A2 and SLC7A5/LAT1 plays a role in HCV propagation by facilitating viral entry into host cell and increasing L-leucine uptake-mediated mTORC1 signaling activation, thereby contributing to HCV-mediated pathogenesis. {ECO:0000269|PubMed:30341327}.; FUNCTION: (Microbial infection) Acts as a receptor for malaria parasite Plasmodium vivax (Thai isolate) in immature red blood cells. {ECO:0000269|PubMed:34294905}. |
| P52907 | CAPZA1 | S215 | Sugiyama | F-actin-capping protein subunit alpha-1 (CapZ alpha-1) | F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions (PubMed:22891260). Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:A0PFK5, ECO:0000269|PubMed:22891260}. |
| Q9NVS9 | PNPO | S55 | Sugiyama | Pyridoxine-5'-phosphate oxidase (EC 1.4.3.5) (Pyridoxamine-phosphate oxidase) | Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). {ECO:0000269|PubMed:12824491, ECO:0000269|PubMed:15182361, ECO:0000269|PubMed:15772097}. |
| Q9UNH7 | SNX6 | S55 | Sugiyama | Sorting nexin-6 (TRAF4-associated factor 2) [Cleaved into: Sorting nexin-6, N-terminally processed] | Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:19935774). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R (PubMed:17148574). May function as link between transport vesicles and dynactin (Probable). Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network (PubMed:20354142). Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed:24610942). In association with GIT1 involved in EGFR degradation. Promotes lysosomal degradation of CDKN1B (By similarity). May contribute to transcription regulation (Probable). {ECO:0000250|UniProtKB:Q6P8X1, ECO:0000269|PubMed:17148574, ECO:0000269|PubMed:19935774, ECO:0000269|PubMed:20354142, ECO:0000269|PubMed:23085988, ECO:0000269|PubMed:24610942, ECO:0000303|PubMed:19935774, ECO:0000303|PubMed:20830743, ECO:0000305}. |
| P19367 | HK1 | S733 | Sugiyama | Hexokinase-1 (EC 2.7.1.1) (Brain form hexokinase) (Hexokinase type I) (HK I) (Hexokinase-A) | Catalyzes the phosphorylation of various hexoses, such as D-glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6-phosphate, respectively) (PubMed:1637300, PubMed:25316723, PubMed:27374331). Does not phosphorylate N-acetyl-D-glucosamine (PubMed:27374331). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor for bacterial peptidoglycan (PubMed:27374331). When released in the cytosol, N-acetyl-D-glucosamine component of bacterial peptidoglycan inhibits the hexokinase activity of HK1 and causes its dissociation from mitochondrial outer membrane, thereby activating the NLRP3 inflammasome (PubMed:27374331). {ECO:0000250|UniProtKB:P05708, ECO:0000269|PubMed:1637300, ECO:0000269|PubMed:25316723, ECO:0000269|PubMed:27374331}. |
| P12931 | SRC | S225 | Sugiyama | Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src) | Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors (PubMed:34234773). Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates such as AFAP1. Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1 and to localize to actin filaments. Cytoskeletal reorganization is also controlled through the phosphorylation of cortactin (CTTN) (Probable). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN) (PubMed:21411625). In addition to phosphorylating focal adhesion proteins, SRC is also active at the sites of cell-cell contact adherens junctions and phosphorylates substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1), and plakoglobin (JUP). Another type of cell-cell junction, the gap junction, is also a target for SRC, which phosphorylates connexin-43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing and phosphorylates RNA-binding proteins such as KHDRBS1 (Probable). Phosphorylates PKP3 at 'Tyr-195' in response to reactive oxygen species, which may cause the release of PKP3 from desmosome cell junctions into the cytoplasm (PubMed:25501895). Also plays a role in PDGF-mediated tyrosine phosphorylation of both STAT1 and STAT3, leading to increased DNA binding activity of these transcription factors (By similarity). Involved in the RAS pathway through phosphorylation of RASA1 and RASGRF1 (PubMed:11389730). Plays a role in EGF-mediated calcium-activated chloride channel activation (PubMed:18586953). Required for epidermal growth factor receptor (EGFR) internalization through phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr-1477'. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization through phosphorylation and activation of GRK2, leading to beta-arrestin phosphorylation and internalization. Has a critical role in the stimulation of the CDK20/MAPK3 mitogen-activated protein kinase cascade by epidermal growth factor (Probable). Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus (PubMed:7853507). Plays an important role in osteoclastic bone resorption in conjunction with PTK2B/PYK2. Both the formation of a SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for this function. Recruited to activated integrins by PTK2B/PYK2, thereby phosphorylating CBL, which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:14585963, PubMed:8755529). Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase (PubMed:12615910). Phosphorylates DDR2 on tyrosine residues, thereby promoting its subsequent autophosphorylation (PubMed:16186108). Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731' (PubMed:20100835, PubMed:21309750). Enhances RIGI-elicited antiviral signaling (PubMed:19419966). Phosphorylates PDPK1 at 'Tyr-9', 'Tyr-373' and 'Tyr-376' (PubMed:14585963). Phosphorylates BCAR1 at 'Tyr-128' (PubMed:22710723). Phosphorylates CBLC at multiple tyrosine residues, phosphorylation at 'Tyr-341' activates CBLC E3 activity (PubMed:20525694). Phosphorylates synaptic vesicle protein synaptophysin (SYP) (By similarity). Involved in anchorage-independent cell growth (PubMed:19307596). Required for podosome formation (By similarity). Mediates IL6 signaling by activating YAP1-NOTCH pathway to induce inflammation-induced epithelial regeneration (PubMed:25731159). Phosphorylates OTUB1, promoting deubiquitination of RPTOR (PubMed:35927303). Phosphorylates caspase CASP8 at 'Tyr-380' which negatively regulates CASP8 processing and activation, down-regulating CASP8 proapoptotic function (PubMed:16619028). {ECO:0000250|UniProtKB:P05480, ECO:0000250|UniProtKB:Q9WUD9, ECO:0000269|PubMed:11389730, ECO:0000269|PubMed:12615910, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:16186108, ECO:0000269|PubMed:16619028, ECO:0000269|PubMed:18586953, ECO:0000269|PubMed:19307596, ECO:0000269|PubMed:19419966, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:20525694, ECO:0000269|PubMed:21309750, ECO:0000269|PubMed:21411625, ECO:0000269|PubMed:22710723, ECO:0000269|PubMed:25501895, ECO:0000269|PubMed:25731159, ECO:0000269|PubMed:34234773, ECO:0000269|PubMed:35927303, ECO:0000269|PubMed:7853507, ECO:0000269|PubMed:8755529, ECO:0000269|PubMed:8759729, ECO:0000305|PubMed:11964124, ECO:0000305|PubMed:8672527, ECO:0000305|PubMed:9442882}.; FUNCTION: [Isoform 1]: Non-receptor protein tyrosine kinase which phosphorylates synaptophysin with high affinity. {ECO:0000250|UniProtKB:Q9WUD9}.; FUNCTION: [Isoform 2]: Non-receptor protein tyrosine kinase which shows higher basal kinase activity than isoform 1, possibly due to weakened intramolecular interactions which enhance autophosphorylation of Tyr-419 and subsequent activation (By similarity). The SH3 domain shows reduced affinity with the linker sequence between the SH2 and kinase domains which may account for the increased basal activity (By similarity). Displays altered substrate specificity compared to isoform 1, showing weak affinity for synaptophysin and for peptide substrates containing class I or class II SH3 domain-binding motifs (By similarity). Plays a role in L1CAM-mediated neurite elongation, possibly by acting downstream of L1CAM to drive cytoskeletal rearrangements involved in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q9WUD9}.; FUNCTION: [Isoform 3]: Non-receptor protein tyrosine kinase which shows higher basal kinase activity than isoform 1, possibly due to weakened intramolecular interactions which enhance autophosphorylation of Tyr-419 and subsequent activation (By similarity). The SH3 domain shows reduced affinity with the linker sequence between the SH2 and kinase domains which may account for the increased basal activity (By similarity). Displays altered substrate specificity compared to isoform 1, showing weak affinity for synaptophysin and for peptide substrates containing class I or class II SH3 domain-binding motifs (By similarity). Plays a role in neurite elongation (By similarity). {ECO:0000250|UniProtKB:Q9WUD9}. |
| P14616 | INSRR | S1271 | Sugiyama | Insulin receptor-related protein (IRR) (EC 2.7.10.1) (IR-related receptor) [Cleaved into: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain] | Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB. {ECO:0000269|PubMed:21641549}. |
| P29597 | TYK2 | S912 | Sugiyama | Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2) | Tyrosine kinase of the non-receptor type involved in numerous cytokines and interferons signaling, which regulates cell growth, development, cell migration, innate and adaptive immunity (PubMed:10542297, PubMed:10995743, PubMed:7657660, PubMed:7813427, PubMed:8232552). Plays both structural and catalytic roles in numerous interleukins and interferons (IFN-alpha/beta) signaling (PubMed:10542297). Associates with heterodimeric cytokine receptor complexes and activates STAT family members including STAT1, STAT3, STAT4 or STAT6 (PubMed:10542297, PubMed:7638186). The heterodimeric cytokine receptor complexes are composed of (1) a TYK2-associated receptor chain (IFNAR1, IL12RB1, IL10RB or IL13RA1), and (2) a second receptor chain associated either with JAK1 or JAK2 (PubMed:10542297, PubMed:25762719, PubMed:7526154, PubMed:7813427). In response to cytokine-binding to receptors, phosphorylates and activates receptors (IFNAR1, IL12RB1, IL10RB or IL13RA1), creating docking sites for STAT members (PubMed:7526154, PubMed:7657660). In turn, recruited STATs are phosphorylated by TYK2 (or JAK1/JAK2 on the second receptor chain), form homo- and heterodimers, translocate to the nucleus, and regulate cytokine/growth factor responsive genes (PubMed:10542297, PubMed:25762719, PubMed:7657660). Negatively regulates STAT3 activity by promototing phosphorylation at a specific tyrosine that differs from the site used for signaling (PubMed:29162862). {ECO:0000269|PubMed:10542297, ECO:0000269|PubMed:10995743, ECO:0000269|PubMed:25762719, ECO:0000269|PubMed:29162862, ECO:0000269|PubMed:7526154, ECO:0000269|PubMed:7638186, ECO:0000269|PubMed:7657660, ECO:0000269|PubMed:7813427, ECO:0000269|PubMed:8232552}. |
| P36894 | BMPR1A | S205 | Sugiyama | Bone morphogenetic protein receptor type-1A (BMP type-1A receptor) (BMPR-1A) (EC 2.7.11.30) (Activin receptor-like kinase 3) (ALK-3) (Serine/threonine-protein kinase receptor R5) (SKR5) (CD antigen CD292) | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6. May promote the expression of HAMP, potentially via its interaction with BMP2 (By similarity). {ECO:0000250|UniProtKB:P36895}. |
| P07195 | LDHB | S70 | Sugiyama | L-lactate dehydrogenase B chain (LDH-B) (EC 1.1.1.27) (LDH heart subunit) (LDH-H) (Renal carcinoma antigen NY-REN-46) | Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). {ECO:0000269|PubMed:27618187}. |
| P08151 | GLI1 | S521 | GPS6 | Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI) | Acts as a transcriptional activator (PubMed:10806483, PubMed:19706761, PubMed:19878745, PubMed:24076122, PubMed:24217340, PubMed:24311597). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:24217340, PubMed:8378770). Regulates the transcription of specific genes during normal development (PubMed:19706761). Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761, PubMed:28973407). Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed:11238441, PubMed:28973407). {ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:19706761, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:2105456, ECO:0000269|PubMed:24076122, ECO:0000269|PubMed:24217340, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:28973407, ECO:0000269|PubMed:8378770}.; FUNCTION: [Isoform 2]: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration. {ECO:0000269|PubMed:19706761}. |
| Q16539 | MAPK14 | S261 | Sugiyama | Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAP kinase MXI2) (MAX-interacting protein 2) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a) (SAPK2a) | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1 (PubMed:9687510, PubMed:9792677). RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery (PubMed:9687510, PubMed:9792677). On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2 (PubMed:11154262). MAPK14 also interacts with casein kinase II, leading to its activation through autophosphorylation and further phosphorylation of TP53/p53 (PubMed:10747897). In the cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. In a similar way, MAPK14 phosphorylates the ubiquitin ligase SIAH2, regulating its activity towards EGLN3 (PubMed:17003045). MAPK14 may also inhibit the lysosomal degradation pathway of autophagy by interfering with the intracellular trafficking of the transmembrane protein ATG9 (PubMed:19893488). Another function of MAPK14 is to regulate the endocytosis of membrane receptors by different mechanisms that impinge on the small GTPase RAB5A. In addition, clathrin-mediated EGFR internalization induced by inflammatory cytokines and UV irradiation depends on MAPK14-mediated phosphorylation of EGFR itself as well as of RAB5A effectors (PubMed:16932740). Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17 (PubMed:20188673). Such phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR signaling and cell proliferation. Another p38 MAPK substrate is FGFR1. FGFR1 can be translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A (PubMed:10330143, PubMed:9430721, PubMed:9858528). The p38 MAPKs are emerging as important modulators of gene expression by regulating chromatin modifiers and remodelers. The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on 'Ser-10' (H3S10ph) in LPS-stimulated myeloid cells. This phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for increased NF-kappa-B recruitment. Phosphorylates CDC25B and CDC25C which is required for binding to 14-3-3 proteins and leads to initiation of a G2 delay after ultraviolet radiation (PubMed:11333986). Phosphorylates TIAR following DNA damage, releasing TIAR from GADD45A mRNA and preventing mRNA degradation (PubMed:20932473). The p38 MAPKs may also have kinase-independent roles, which are thought to be due to the binding to targets in the absence of phosphorylation. Protein O-Glc-N-acylation catalyzed by the OGT is regulated by MAPK14, and, although OGT does not seem to be phosphorylated by MAPK14, their interaction increases upon MAPK14 activation induced by glucose deprivation. This interaction may regulate OGT activity by recruiting it to specific targets such as neurofilament H, stimulating its O-Glc-N-acylation. Required in mid-fetal development for the growth of embryo-derived blood vessels in the labyrinth layer of the placenta. Also plays an essential role in developmental and stress-induced erythropoiesis, through regulation of EPO gene expression (PubMed:10943842). Isoform MXI2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform EXIP may play a role in the early onset of apoptosis. Phosphorylates S100A9 at 'Thr-113' (PubMed:15905572). Phosphorylates NLRP1 downstream of MAP3K20/ZAK in response to UV-B irradiation and ribosome collisions, promoting activation of the NLRP1 inflammasome and pyroptosis (PubMed:35857590). {ECO:0000269|PubMed:10330143, ECO:0000269|PubMed:10747897, ECO:0000269|PubMed:10943842, ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:11333986, ECO:0000269|PubMed:15905572, ECO:0000269|PubMed:16932740, ECO:0000269|PubMed:17003045, ECO:0000269|PubMed:17724032, ECO:0000269|PubMed:19893488, ECO:0000269|PubMed:20188673, ECO:0000269|PubMed:20932473, ECO:0000269|PubMed:35857590, ECO:0000269|PubMed:9430721, ECO:0000269|PubMed:9687510, ECO:0000269|PubMed:9792677, ECO:0000269|PubMed:9858528}.; FUNCTION: (Microbial infection) Activated by phosphorylation by M.tuberculosis EsxA in T-cells leading to inhibition of IFN-gamma production; phosphorylation is apparent within 15 minutes and is inhibited by kinase-specific inhibitors SB203580 and siRNA (PubMed:21586573). {ECO:0000269|PubMed:21586573}. |
| Q00610 | CLTC | S1466 | Sugiyama | Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17) | Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872). Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilization of the lattice promoting uncoating (By similarity). {ECO:0000250|UniProtKB:P49951, ECO:0000269|PubMed:15858577, ECO:0000269|PubMed:16968737, ECO:0000269|PubMed:20639872, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}. |
| Q86Y07 | VRK2 | S218 | Sugiyama | Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2) | Serine/threonine kinase that regulates several signal transduction pathways (PubMed:14645249, PubMed:16495336, PubMed:16704422, PubMed:17709393, PubMed:18286207, PubMed:18617507, PubMed:20679487). Isoform 1 modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes (PubMed:17709393). Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription (PubMed:18286207). Phosphorylates 'Thr-18' of p53/TP53, histone H3, and may also phosphorylate MAPK8IP1 (PubMed:16704422). Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins (PubMed:16495336). Down-regulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1 (PubMed:20679487). Blocks the phosphorylation of ERK in response to ERBB2 and HRAS (PubMed:20679487). Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevant (PubMed:14645249). {ECO:0000269|PubMed:14645249, ECO:0000269|PubMed:16495336, ECO:0000269|PubMed:16704422, ECO:0000269|PubMed:17709393, ECO:0000269|PubMed:18286207, ECO:0000269|PubMed:18617507, ECO:0000269|PubMed:20679487}.; FUNCTION: [Isoform 2]: Phosphorylates 'Thr-18' of p53/TP53, as well as histone H3. Reduces p53/TP53 ubiquitination by MDM2, promotes p53/TP53 acetylation by EP300 and thereby increases p53/TP53 stability and activity. {ECO:0000269|PubMed:16704422}. |
| Q14524 | SCN5A | S20 | PSP | Sodium channel protein type 5 subunit alpha (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (hH1) | Pore-forming subunit of Nav1.5, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:1309946, PubMed:21447824, PubMed:23085483, PubMed:23420830, PubMed:25370050, PubMed:26279430, PubMed:26392562, PubMed:26776555). Nav1.5 is the predominant sodium channel expressed in myocardial cells and it is responsible for the initial upstroke of the action potential in cardiac myocytes, thereby initiating the heartbeat (PubMed:11234013, PubMed:11804990, PubMed:12569159, PubMed:1309946). Required for normal electrical conduction including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with XIRP2 (By similarity). {ECO:0000250|UniProtKB:Q9JJV9, ECO:0000269|PubMed:11234013, ECO:0000269|PubMed:11804990, ECO:0000269|PubMed:12569159, ECO:0000269|PubMed:1309946, ECO:0000269|PubMed:19074138, ECO:0000269|PubMed:21447824, ECO:0000269|PubMed:23085483, ECO:0000269|PubMed:23420830, ECO:0000269|PubMed:24167619, ECO:0000269|PubMed:25370050, ECO:0000269|PubMed:26279430, ECO:0000269|PubMed:26392562, ECO:0000269|PubMed:26776555}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-422475 | Axon guidance | 0.000015 | 4.835 |
| R-HSA-9675108 | Nervous system development | 0.000014 | 4.854 |
| R-HSA-196025 | Formation of annular gap junctions | 0.000033 | 4.486 |
| R-HSA-190873 | Gap junction degradation | 0.000046 | 4.340 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 0.000062 | 4.206 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.000141 | 3.852 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.000141 | 3.852 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.000173 | 3.762 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.000196 | 3.708 |
| R-HSA-437239 | Recycling pathway of L1 | 0.000277 | 3.558 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.000263 | 3.579 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.000404 | 3.393 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 0.000982 | 3.008 |
| R-HSA-373760 | L1CAM interactions | 0.001236 | 2.908 |
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 0.001235 | 2.908 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.001177 | 2.929 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 0.001524 | 2.817 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 0.001853 | 2.732 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.002018 | 2.695 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.002312 | 2.636 |
| R-HSA-877300 | Interferon gamma signaling | 0.002288 | 2.640 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.002551 | 2.593 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.002754 | 2.560 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.003036 | 2.518 |
| R-HSA-8939211 | ESR-mediated signaling | 0.002956 | 2.529 |
| R-HSA-162582 | Signal Transduction | 0.003912 | 2.408 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.003776 | 2.423 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.004360 | 2.361 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.004743 | 2.324 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.004743 | 2.324 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.005574 | 2.254 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.005574 | 2.254 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.005480 | 2.261 |
| R-HSA-913531 | Interferon Signaling | 0.005579 | 2.253 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.006119 | 2.213 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.006255 | 2.204 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.006508 | 2.187 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.006746 | 2.171 |
| R-HSA-5635851 | GLI proteins bind promoters of Hh responsive genes to promote transcription | 0.007354 | 2.133 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.007005 | 2.155 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.008067 | 2.093 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.008067 | 2.093 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.007665 | 2.116 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.009239 | 2.034 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.009865 | 2.006 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 0.009211 | 2.036 |
| R-HSA-373752 | Netrin-1 signaling | 0.009865 | 2.006 |
| R-HSA-190828 | Gap junction trafficking | 0.009865 | 2.006 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.009898 | 2.004 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.010905 | 1.962 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.011197 | 1.951 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.011197 | 1.951 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.011197 | 1.951 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.011197 | 1.951 |
| R-HSA-199991 | Membrane Trafficking | 0.010849 | 1.965 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.011433 | 1.942 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 0.011255 | 1.949 |
| R-HSA-75153 | Apoptotic execution phase | 0.011197 | 1.951 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.011905 | 1.924 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.012542 | 1.902 |
| R-HSA-9659379 | Sensory processing of sound | 0.013123 | 1.882 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 0.013478 | 1.870 |
| R-HSA-5467343 | Deletions in the AMER1 gene destabilize the destruction complex | 0.015711 | 1.804 |
| R-HSA-9700645 | ALK mutants bind TKIs | 0.015875 | 1.799 |
| R-HSA-176974 | Unwinding of DNA | 0.015875 | 1.799 |
| R-HSA-9834752 | Respiratory syncytial virus genome replication | 0.015875 | 1.799 |
| R-HSA-8851680 | Butyrophilin (BTN) family interactions | 0.015875 | 1.799 |
| R-HSA-168256 | Immune System | 0.016367 | 1.786 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.016992 | 1.770 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.017703 | 1.752 |
| R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 0.018440 | 1.734 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.018572 | 1.731 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.019184 | 1.717 |
| R-HSA-210990 | PECAM1 interactions | 0.021168 | 1.674 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.021553 | 1.666 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.024051 | 1.619 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.024051 | 1.619 |
| R-HSA-354192 | Integrin signaling | 0.024716 | 1.607 |
| R-HSA-194138 | Signaling by VEGF | 0.025138 | 1.600 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 0.027085 | 1.567 |
| R-HSA-373755 | Semaphorin interactions | 0.027257 | 1.565 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.029738 | 1.527 |
| R-HSA-187687 | Signalling to ERKs | 0.029835 | 1.525 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 0.030265 | 1.519 |
| R-HSA-169131 | Inhibition of PKR | 0.031177 | 1.506 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.033584 | 1.474 |
| R-HSA-391160 | Signal regulatory protein family interactions | 0.033584 | 1.474 |
| R-HSA-8853659 | RET signaling | 0.031656 | 1.500 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.031836 | 1.497 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.033703 | 1.472 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.034712 | 1.460 |
| R-HSA-1483255 | PI Metabolism | 0.035092 | 1.455 |
| R-HSA-9027284 | Erythropoietin activates RAS | 0.037039 | 1.431 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.040624 | 1.391 |
| R-HSA-171007 | p38MAPK events | 0.037039 | 1.431 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.037039 | 1.431 |
| R-HSA-196780 | Biotin transport and metabolism | 0.037039 | 1.431 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.037039 | 1.431 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.037279 | 1.429 |
| R-HSA-2559583 | Cellular Senescence | 0.040692 | 1.390 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.041853 | 1.378 |
| R-HSA-6798695 | Neutrophil degranulation | 0.042736 | 1.369 |
| R-HSA-1640170 | Cell Cycle | 0.043220 | 1.364 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.043337 | 1.363 |
| R-HSA-5619056 | Defective HK1 causes hexokinase deficiency (HK deficiency) | 0.046400 | 1.333 |
| R-HSA-5619054 | Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalit... | 0.046400 | 1.333 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 0.061385 | 1.212 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 0.061385 | 1.212 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 0.061385 | 1.212 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 0.061385 | 1.212 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 0.061385 | 1.212 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 0.061385 | 1.212 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 0.061385 | 1.212 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 0.061385 | 1.212 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 0.061385 | 1.212 |
| R-HSA-68881 | Mitotic Metaphase/Anaphase Transition | 0.061385 | 1.212 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 0.061385 | 1.212 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 0.061385 | 1.212 |
| R-HSA-5660862 | Defective SLC7A7 causes lysinuric protein intolerance (LPI) | 0.076136 | 1.118 |
| R-HSA-1306955 | GRB7 events in ERBB2 signaling | 0.090655 | 1.043 |
| R-HSA-74713 | IRS activation | 0.104948 | 0.979 |
| R-HSA-3656244 | Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) | 0.132864 | 0.877 |
| R-HSA-9027283 | Erythropoietin activates STAT5 | 0.132864 | 0.877 |
| R-HSA-3656243 | Defective ST3GAL3 causes MCT12 and EIEE15 | 0.132864 | 0.877 |
| R-HSA-3656225 | Defective CHST6 causes MCDC1 | 0.132864 | 0.877 |
| R-HSA-447041 | CHL1 interactions | 0.146496 | 0.834 |
| R-HSA-112412 | SOS-mediated signalling | 0.146496 | 0.834 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 0.146496 | 0.834 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.048163 | 1.317 |
| R-HSA-446107 | Type I hemidesmosome assembly | 0.159914 | 0.796 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 0.159914 | 0.796 |
| R-HSA-9768778 | Regulation of NPAS4 mRNA translation | 0.159914 | 0.796 |
| R-HSA-170984 | ARMS-mediated activation | 0.173122 | 0.762 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 0.186122 | 0.730 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 0.186122 | 0.730 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 0.186122 | 0.730 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.198920 | 0.701 |
| R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | 0.198920 | 0.701 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.198920 | 0.701 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.198920 | 0.701 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.198920 | 0.701 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 0.211517 | 0.675 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.211517 | 0.675 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 0.223916 | 0.650 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.223916 | 0.650 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 0.223916 | 0.650 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.223916 | 0.650 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.223916 | 0.650 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.223916 | 0.650 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.223916 | 0.650 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.096973 | 1.013 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.236122 | 0.627 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.106922 | 0.971 |
| R-HSA-177504 | Retrograde neurotrophin signalling | 0.248136 | 0.605 |
| R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 0.259962 | 0.585 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 0.259962 | 0.585 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.259962 | 0.585 |
| R-HSA-168275 | Entry of Influenza Virion into Host Cell via Endocytosis | 0.271602 | 0.566 |
| R-HSA-1221632 | Meiotic synapsis | 0.073800 | 1.132 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.073800 | 1.132 |
| R-HSA-72649 | Translation initiation complex formation | 0.076630 | 1.116 |
| R-HSA-975110 | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | 0.283060 | 0.548 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.082430 | 1.084 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.294339 | 0.531 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.294339 | 0.531 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.104133 | 0.982 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.104133 | 0.982 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.316369 | 0.500 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.114056 | 0.943 |
| R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 0.327126 | 0.485 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.327126 | 0.485 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.327126 | 0.485 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.327126 | 0.485 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.327126 | 0.485 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.327126 | 0.485 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.337714 | 0.471 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.337714 | 0.471 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.205297 | 0.688 |
| R-HSA-774815 | Nucleosome assembly | 0.205297 | 0.688 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.138504 | 0.859 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.348136 | 0.458 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.348136 | 0.458 |
| R-HSA-380287 | Centrosome maturation | 0.145793 | 0.836 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.245869 | 0.609 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.199898 | 0.699 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.292533 | 0.534 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.296250 | 0.528 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.168371 | 0.774 |
| R-HSA-3928664 | Ephrin signaling | 0.305441 | 0.515 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.111995 | 0.951 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.266347 | 0.575 |
| R-HSA-9603381 | Activated NTRK3 signals through PI3K | 0.146496 | 0.834 |
| R-HSA-198203 | PI3K/AKT activation | 0.186122 | 0.730 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 0.073414 | 1.134 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.211054 | 0.676 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.114531 | 0.941 |
| R-HSA-191650 | Regulation of gap junction activity | 0.090655 | 1.043 |
| R-HSA-1500620 | Meiosis | 0.061723 | 1.210 |
| R-HSA-5693538 | Homology Directed Repair | 0.347846 | 0.459 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.286708 | 0.543 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.052945 | 1.276 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.139606 | 0.855 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.131345 | 0.882 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.322040 | 0.492 |
| R-HSA-1059683 | Interleukin-6 signaling | 0.236122 | 0.627 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.092104 | 1.036 |
| R-HSA-68877 | Mitotic Prometaphase | 0.247093 | 0.607 |
| R-HSA-1606341 | IRF3 mediated activation of type 1 IFN | 0.104948 | 0.979 |
| R-HSA-1483152 | Hydrolysis of LPE | 0.132864 | 0.877 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 0.236122 | 0.627 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 0.248136 | 0.605 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.180021 | 0.745 |
| R-HSA-6788467 | IL-6-type cytokine receptor ligand interactions | 0.236122 | 0.627 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.052108 | 1.283 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.117130 | 0.931 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.339249 | 0.469 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.338812 | 0.470 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.333069 | 0.477 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 0.119016 | 0.924 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.176817 | 0.752 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 0.348136 | 0.458 |
| R-HSA-912446 | Meiotic recombination | 0.240044 | 0.620 |
| R-HSA-9020933 | Interleukin-23 signaling | 0.159914 | 0.796 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.091705 | 1.038 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.251700 | 0.599 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.339249 | 0.469 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.122323 | 0.912 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 0.348136 | 0.458 |
| R-HSA-445144 | Signal transduction by L1 | 0.327126 | 0.485 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.241030 | 0.618 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.274859 | 0.561 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.300542 | 0.522 |
| R-HSA-9636667 | Manipulation of host energy metabolism | 0.046400 | 1.333 |
| R-HSA-8875513 | MET interacts with TNS proteins | 0.076136 | 1.118 |
| R-HSA-176417 | Phosphorylation of Emi1 | 0.119016 | 0.924 |
| R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 0.186122 | 0.730 |
| R-HSA-2151209 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation | 0.186122 | 0.730 |
| R-HSA-4839744 | Signaling by APC mutants | 0.198920 | 0.701 |
| R-HSA-192905 | vRNP Assembly | 0.198920 | 0.701 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.211517 | 0.675 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.223916 | 0.650 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 0.223916 | 0.650 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.236122 | 0.627 |
| R-HSA-176412 | Phosphorylation of the APC/C | 0.271602 | 0.566 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.149056 | 0.827 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.088413 | 1.053 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.305441 | 0.515 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.228529 | 0.641 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.344540 | 0.463 |
| R-HSA-68875 | Mitotic Prophase | 0.063533 | 1.197 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.052108 | 1.283 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.108101 | 0.966 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.088013 | 1.055 |
| R-HSA-9664407 | Parasite infection | 0.238934 | 0.622 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.238934 | 0.622 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.238934 | 0.622 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.345542 | 0.461 |
| R-HSA-68886 | M Phase | 0.192185 | 0.716 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 0.048163 | 1.317 |
| R-HSA-74749 | Signal attenuation | 0.186122 | 0.730 |
| R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 0.082594 | 1.083 |
| R-HSA-9620244 | Long-term potentiation | 0.087310 | 1.059 |
| R-HSA-3295583 | TRP channels | 0.092104 | 1.036 |
| R-HSA-3371511 | HSF1 activation | 0.149056 | 0.827 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.134908 | 0.870 |
| R-HSA-9020956 | Interleukin-27 signaling | 0.186122 | 0.730 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 0.198920 | 0.701 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 0.271602 | 0.566 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 0.327126 | 0.485 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 0.327126 | 0.485 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.234225 | 0.630 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.224389 | 0.649 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.305441 | 0.515 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.149056 | 0.827 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.294331 | 0.531 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.098023 | 1.009 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.266347 | 0.575 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.234623 | 0.630 |
| R-HSA-432142 | Platelet sensitization by LDL | 0.052108 | 1.283 |
| R-HSA-442380 | Zinc influx into cells by the SLC39 gene family | 0.173122 | 0.762 |
| R-HSA-112411 | MAPK1 (ERK2) activation | 0.173122 | 0.762 |
| R-HSA-426048 | Arachidonate production from DAG | 0.186122 | 0.730 |
| R-HSA-1855167 | Synthesis of pyrophosphates in the cytosol | 0.077961 | 1.108 |
| R-HSA-1483115 | Hydrolysis of LPC | 0.248136 | 0.605 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 0.138221 | 0.859 |
| R-HSA-964975 | Vitamin B6 activation to pyridoxal phosphate | 0.283060 | 0.548 |
| R-HSA-8875878 | MET promotes cell motility | 0.160056 | 0.796 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.165610 | 0.781 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.138504 | 0.859 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.211054 | 0.676 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.296250 | 0.528 |
| R-HSA-169893 | Prolonged ERK activation events | 0.271602 | 0.566 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.245869 | 0.609 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.085399 | 1.069 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.222616 | 0.652 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.173986 | 0.759 |
| R-HSA-69275 | G2/M Transition | 0.226803 | 0.644 |
| R-HSA-167044 | Signalling to RAS | 0.064593 | 1.190 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.100905 | 0.996 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.232550 | 0.633 |
| R-HSA-2022857 | Keratan sulfate degradation | 0.327126 | 0.485 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.263371 | 0.579 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.088469 | 1.053 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.173986 | 0.759 |
| R-HSA-1474165 | Reproduction | 0.202453 | 0.694 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.136812 | 0.864 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.305441 | 0.515 |
| R-HSA-3214847 | HATs acetylate histones | 0.253643 | 0.596 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 0.316369 | 0.500 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.222616 | 0.652 |
| R-HSA-9833110 | RSV-host interactions | 0.114020 | 0.943 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.244165 | 0.612 |
| R-HSA-9927353 | Co-inhibition by BTLA | 0.104948 | 0.979 |
| R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 | 0.132864 | 0.877 |
| R-HSA-3371599 | Defective HLCS causes multiple carboxylase deficiency | 0.146496 | 0.834 |
| R-HSA-418886 | Netrin mediated repulsion signals | 0.146496 | 0.834 |
| R-HSA-110056 | MAPK3 (ERK1) activation | 0.186122 | 0.730 |
| R-HSA-425381 | Bicarbonate transporters | 0.198920 | 0.701 |
| R-HSA-446205 | Synthesis of GDP-mannose | 0.223916 | 0.650 |
| R-HSA-877312 | Regulation of IFNG signaling | 0.223916 | 0.650 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.085399 | 1.069 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.348136 | 0.458 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.142133 | 0.847 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.240044 | 0.620 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.245869 | 0.609 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.251700 | 0.599 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.085799 | 1.067 |
| R-HSA-9612973 | Autophagy | 0.144407 | 0.840 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.130099 | 0.886 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 0.087310 | 1.059 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.130099 | 0.886 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.116636 | 0.933 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.135659 | 0.868 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.061723 | 1.210 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 0.173122 | 0.762 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.127571 | 0.894 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 0.283060 | 0.548 |
| R-HSA-844456 | The NLRP3 inflammasome | 0.316369 | 0.500 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.205297 | 0.688 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.100905 | 0.996 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.348136 | 0.458 |
| R-HSA-69481 | G2/M Checkpoints | 0.076989 | 1.114 |
| R-HSA-449147 | Signaling by Interleukins | 0.053429 | 1.272 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.104948 | 0.979 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 0.104948 | 0.979 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 0.159914 | 0.796 |
| R-HSA-450341 | Activation of the AP-1 family of transcription factors | 0.173122 | 0.762 |
| R-HSA-428542 | Regulation of commissural axon pathfinding by SLIT and ROBO | 0.173122 | 0.762 |
| R-HSA-210991 | Basigin interactions | 0.064593 | 1.190 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.248136 | 0.605 |
| R-HSA-419408 | Lysosphingolipid and LPA receptors | 0.259962 | 0.585 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.259962 | 0.585 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 0.271602 | 0.566 |
| R-HSA-3371568 | Attenuation phase | 0.171198 | 0.767 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 0.337714 | 0.471 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.155847 | 0.807 |
| R-HSA-5617833 | Cilium Assembly | 0.116946 | 0.932 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.199222 | 0.701 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.094573 | 1.024 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.187907 | 0.726 |
| R-HSA-186763 | Downstream signal transduction | 0.117130 | 0.931 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.117130 | 0.931 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 0.294339 | 0.531 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.266363 | 0.575 |
| R-HSA-168249 | Innate Immune System | 0.307315 | 0.512 |
| R-HSA-70171 | Glycolysis | 0.257868 | 0.589 |
| R-HSA-1266738 | Developmental Biology | 0.114684 | 0.940 |
| R-HSA-1280218 | Adaptive Immune System | 0.332152 | 0.479 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.066417 | 1.178 |
| R-HSA-168255 | Influenza Infection | 0.096915 | 1.014 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.342753 | 0.465 |
| R-HSA-9658195 | Leishmania infection | 0.342753 | 0.465 |
| R-HSA-3323169 | Defects in biotin (Btn) metabolism | 0.173122 | 0.762 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.248136 | 0.605 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 0.294339 | 0.531 |
| R-HSA-1482922 | Acyl chain remodelling of PI | 0.327126 | 0.485 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.078771 | 1.104 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.257534 | 0.589 |
| R-HSA-1632852 | Macroautophagy | 0.242327 | 0.616 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.090124 | 1.045 |
| R-HSA-109582 | Hemostasis | 0.141226 | 0.850 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.120410 | 0.919 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.269833 | 0.569 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.076995 | 1.114 |
| R-HSA-392518 | Signal amplification | 0.138221 | 0.859 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.060385 | 1.219 |
| R-HSA-446728 | Cell junction organization | 0.196340 | 0.707 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.208423 | 0.681 |
| R-HSA-8984722 | Interleukin-35 Signalling | 0.223916 | 0.650 |
| R-HSA-435354 | Zinc transporters | 0.248136 | 0.605 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.348136 | 0.458 |
| R-HSA-1500931 | Cell-Cell communication | 0.088851 | 1.051 |
| R-HSA-8849468 | PTK6 Regulates Proteins Involved in RNA Processing | 0.104948 | 0.979 |
| R-HSA-9032500 | Activated NTRK2 signals through FYN | 0.159914 | 0.796 |
| R-HSA-8934903 | Receptor Mediated Mitophagy | 0.186122 | 0.730 |
| R-HSA-9635465 | Suppression of apoptosis | 0.198920 | 0.701 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 0.096973 | 1.013 |
| R-HSA-912631 | Regulation of signaling by CBL | 0.316369 | 0.500 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.327126 | 0.485 |
| R-HSA-198753 | ERK/MAPK targets | 0.337714 | 0.471 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.348136 | 0.458 |
| R-HSA-166520 | Signaling by NTRKs | 0.050249 | 1.299 |
| R-HSA-69190 | DNA strand elongation | 0.122323 | 0.912 |
| R-HSA-2028269 | Signaling by Hippo | 0.294339 | 0.531 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.188139 | 0.726 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.294824 | 0.530 |
| R-HSA-418990 | Adherens junctions interactions | 0.178520 | 0.748 |
| R-HSA-418889 | Caspase activation via Dependence Receptors in the absence of ligand | 0.173122 | 0.762 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.271602 | 0.566 |
| R-HSA-977347 | Serine metabolism | 0.348136 | 0.458 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.269208 | 0.570 |
| R-HSA-70326 | Glucose metabolism | 0.343549 | 0.464 |
| R-HSA-421270 | Cell-cell junction organization | 0.260908 | 0.584 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.255932 | 0.592 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.190590 | 0.720 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.190590 | 0.720 |
| R-HSA-1483257 | Phospholipid metabolism | 0.130069 | 0.886 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 0.198920 | 0.701 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.223916 | 0.650 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.315760 | 0.501 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.312005 | 0.506 |
| R-HSA-2262752 | Cellular responses to stress | 0.102527 | 0.989 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.077961 | 1.108 |
| R-HSA-2586552 | Signaling by Leptin | 0.186122 | 0.730 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.068957 | 1.161 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.245869 | 0.609 |
| R-HSA-186797 | Signaling by PDGF | 0.304164 | 0.517 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.226692 | 0.645 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 0.259962 | 0.585 |
| R-HSA-180292 | GAB1 signalosome | 0.305441 | 0.515 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.145793 | 0.836 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.119277 | 0.923 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.143065 | 0.844 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.276798 | 0.558 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.079428 | 1.100 |
| R-HSA-211000 | Gene Silencing by RNA | 0.291961 | 0.535 |
| R-HSA-201556 | Signaling by ALK | 0.165610 | 0.781 |
| R-HSA-210993 | Tie2 Signaling | 0.305441 | 0.515 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.104133 | 0.982 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 0.193837 | 0.713 |
| R-HSA-5619102 | SLC transporter disorders | 0.336901 | 0.472 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.165610 | 0.781 |
| R-HSA-449836 | Other interleukin signaling | 0.316369 | 0.500 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.160733 | 0.794 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.347846 | 0.459 |
| R-HSA-9679506 | SARS-CoV Infections | 0.205473 | 0.687 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.199557 | 0.700 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.065635 | 1.183 |
| R-HSA-177929 | Signaling by EGFR | 0.269208 | 0.570 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.078122 | 1.107 |
| R-HSA-5357801 | Programmed Cell Death | 0.149447 | 0.826 |
| R-HSA-109581 | Apoptosis | 0.159225 | 0.798 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.235553 | 0.628 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 0.165610 | 0.781 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.245869 | 0.609 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.283792 | 0.547 |
| R-HSA-73887 | Death Receptor Signaling | 0.139606 | 0.855 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.350251 | 0.456 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.350251 | 0.456 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.350251 | 0.456 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.350318 | 0.456 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.355946 | 0.449 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.355946 | 0.449 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 0.358394 | 0.446 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.358394 | 0.446 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.358394 | 0.446 |
| R-HSA-9669938 | Signaling by KIT in disease | 0.358394 | 0.446 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 0.358394 | 0.446 |
| R-HSA-8964038 | LDL clearance | 0.358394 | 0.446 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.358394 | 0.446 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.360720 | 0.443 |
| R-HSA-3371556 | Cellular response to heat stress | 0.360720 | 0.443 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.361623 | 0.442 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.367282 | 0.435 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.367282 | 0.435 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 0.368492 | 0.434 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 0.368492 | 0.434 |
| R-HSA-8854691 | Interleukin-20 family signaling | 0.368492 | 0.434 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 0.368492 | 0.434 |
| R-HSA-200425 | Carnitine shuttle | 0.368492 | 0.434 |
| R-HSA-3000170 | Syndecan interactions | 0.368492 | 0.434 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.369012 | 0.433 |
| R-HSA-6783589 | Interleukin-6 family signaling | 0.378432 | 0.422 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.378432 | 0.422 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.378432 | 0.422 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 0.378432 | 0.422 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.378432 | 0.422 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.378432 | 0.422 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.378432 | 0.422 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.384137 | 0.416 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.384891 | 0.415 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.388216 | 0.411 |
| R-HSA-9839394 | TGFBR3 expression | 0.388216 | 0.411 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.388216 | 0.411 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.388216 | 0.411 |
| R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 0.388216 | 0.411 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 0.388216 | 0.411 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.388216 | 0.411 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 0.388216 | 0.411 |
| R-HSA-3000157 | Laminin interactions | 0.388216 | 0.411 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.388216 | 0.411 |
| R-HSA-195721 | Signaling by WNT | 0.390362 | 0.409 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.395267 | 0.403 |
| R-HSA-4086400 | PCP/CE pathway | 0.395267 | 0.403 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.397846 | 0.400 |
| R-HSA-8874081 | MET activates PTK2 signaling | 0.397846 | 0.400 |
| R-HSA-525793 | Myogenesis | 0.397846 | 0.400 |
| R-HSA-1855183 | Synthesis of IP2, IP, and Ins in the cytosol | 0.397846 | 0.400 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 0.397846 | 0.400 |
| R-HSA-9833482 | PKR-mediated signaling | 0.406304 | 0.391 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.406304 | 0.391 |
| R-HSA-6806834 | Signaling by MET | 0.406304 | 0.391 |
| R-HSA-171306 | Packaging Of Telomere Ends | 0.407325 | 0.390 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.407325 | 0.390 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 0.407325 | 0.390 |
| R-HSA-201451 | Signaling by BMP | 0.407325 | 0.390 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.407325 | 0.390 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.407325 | 0.390 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.407325 | 0.390 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 0.416656 | 0.380 |
| R-HSA-622312 | Inflammasomes | 0.416656 | 0.380 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.416656 | 0.380 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.416656 | 0.380 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.417244 | 0.380 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.425751 | 0.371 |
| R-HSA-5334118 | DNA methylation | 0.425840 | 0.371 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.425840 | 0.371 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 0.425840 | 0.371 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.425840 | 0.371 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.425840 | 0.371 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.425840 | 0.371 |
| R-HSA-180024 | DARPP-32 events | 0.425840 | 0.371 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.425840 | 0.371 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.425840 | 0.371 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.425840 | 0.371 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.433461 | 0.363 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.434881 | 0.362 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.434881 | 0.362 |
| R-HSA-456926 | Thrombin signalling through proteinase activated receptors (PARs) | 0.434881 | 0.362 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.434881 | 0.362 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.434881 | 0.362 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.434881 | 0.362 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 0.434881 | 0.362 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.436772 | 0.360 |
| R-HSA-163685 | Integration of energy metabolism | 0.436772 | 0.360 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.438813 | 0.358 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.438813 | 0.358 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.443779 | 0.353 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.443779 | 0.353 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 0.443779 | 0.353 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.443788 | 0.353 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.444137 | 0.352 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.444137 | 0.352 |
| R-HSA-6807070 | PTEN Regulation | 0.449148 | 0.348 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.449434 | 0.347 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.449434 | 0.347 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.452538 | 0.344 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.452538 | 0.344 |
| R-HSA-156902 | Peptide chain elongation | 0.454702 | 0.342 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.454702 | 0.342 |
| R-HSA-9663891 | Selective autophagy | 0.454702 | 0.342 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.461160 | 0.336 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.461160 | 0.336 |
| R-HSA-2022854 | Keratan sulfate biosynthesis | 0.461160 | 0.336 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.461160 | 0.336 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.461160 | 0.336 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.461160 | 0.336 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.461160 | 0.336 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 0.461160 | 0.336 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.461160 | 0.336 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.461160 | 0.336 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.461160 | 0.336 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.461160 | 0.336 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.464038 | 0.333 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.465185 | 0.332 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.469646 | 0.328 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.469646 | 0.328 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.469646 | 0.328 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.469646 | 0.328 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 0.469646 | 0.328 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.469646 | 0.328 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 0.469646 | 0.328 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 0.469646 | 0.328 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.469646 | 0.328 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.469646 | 0.328 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.470331 | 0.328 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.470331 | 0.328 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.475482 | 0.323 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.477999 | 0.321 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.477999 | 0.321 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.477999 | 0.321 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.477999 | 0.321 |
| R-HSA-203615 | eNOS activation | 0.477999 | 0.321 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.477999 | 0.321 |
| R-HSA-5673000 | RAF activation | 0.477999 | 0.321 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.477999 | 0.321 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.477999 | 0.321 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.477999 | 0.321 |
| R-HSA-5205647 | Mitophagy | 0.477999 | 0.321 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.480602 | 0.318 |
| R-HSA-391251 | Protein folding | 0.480602 | 0.318 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.481592 | 0.317 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.485691 | 0.314 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.486221 | 0.313 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.486221 | 0.313 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.486221 | 0.313 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 0.486221 | 0.313 |
| R-HSA-3296482 | Defects in vitamin and cofactor metabolism | 0.486221 | 0.313 |
| R-HSA-69242 | S Phase | 0.489564 | 0.310 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 0.494314 | 0.306 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.494314 | 0.306 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.494314 | 0.306 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.494314 | 0.306 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.495776 | 0.305 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.500772 | 0.300 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.500772 | 0.300 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 0.502280 | 0.299 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.502280 | 0.299 |
| R-HSA-110331 | Cleavage of the damaged purine | 0.502280 | 0.299 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.502280 | 0.299 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.505326 | 0.296 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.505735 | 0.296 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.509228 | 0.293 |
| R-HSA-69306 | DNA Replication | 0.509228 | 0.293 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.510121 | 0.292 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 0.510121 | 0.292 |
| R-HSA-73927 | Depurination | 0.510121 | 0.292 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.510121 | 0.292 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.510121 | 0.292 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.510121 | 0.292 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.510667 | 0.292 |
| R-HSA-68882 | Mitotic Anaphase | 0.514710 | 0.288 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.517839 | 0.286 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.517839 | 0.286 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 0.517839 | 0.286 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.518012 | 0.286 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.525268 | 0.280 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.525268 | 0.280 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.525436 | 0.279 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.525436 | 0.279 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.525436 | 0.279 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.525436 | 0.279 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.525436 | 0.279 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.525436 | 0.279 |
| R-HSA-9646399 | Aggrephagy | 0.525436 | 0.279 |
| R-HSA-71240 | Tryptophan catabolism | 0.525436 | 0.279 |
| R-HSA-8982491 | Glycogen metabolism | 0.525436 | 0.279 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.525436 | 0.279 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.525436 | 0.279 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.530070 | 0.276 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.530070 | 0.276 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 0.532914 | 0.273 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.532914 | 0.273 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 0.532914 | 0.273 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.532914 | 0.273 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.532914 | 0.273 |
| R-HSA-9694548 | Maturation of spike protein | 0.532914 | 0.273 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.532914 | 0.273 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.534838 | 0.272 |
| R-HSA-192823 | Viral mRNA Translation | 0.539574 | 0.268 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.540274 | 0.267 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.540274 | 0.267 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.544276 | 0.264 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.547519 | 0.262 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 0.547519 | 0.262 |
| R-HSA-73928 | Depyrimidination | 0.547519 | 0.262 |
| R-HSA-165159 | MTOR signalling | 0.547519 | 0.262 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.548945 | 0.260 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.548945 | 0.260 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.551044 | 0.259 |
| R-HSA-9710421 | Defective pyroptosis | 0.554650 | 0.256 |
| R-HSA-8854214 | TBC/RABGAPs | 0.554650 | 0.256 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.554650 | 0.256 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.554650 | 0.256 |
| R-HSA-418346 | Platelet homeostasis | 0.558182 | 0.253 |
| R-HSA-69236 | G1 Phase | 0.561669 | 0.251 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.561669 | 0.251 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.562749 | 0.250 |
| R-HSA-69239 | Synthesis of DNA | 0.562749 | 0.250 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.567284 | 0.246 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.567284 | 0.246 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.568578 | 0.245 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.568578 | 0.245 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.568578 | 0.245 |
| R-HSA-3560782 | Diseases associated with glycosaminoglycan metabolism | 0.568578 | 0.245 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.568578 | 0.245 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.568578 | 0.245 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.568578 | 0.245 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.571784 | 0.243 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.571784 | 0.243 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.575379 | 0.240 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.575379 | 0.240 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.575379 | 0.240 |
| R-HSA-9675135 | Diseases of DNA repair | 0.575379 | 0.240 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.575379 | 0.240 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.575379 | 0.240 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.576539 | 0.239 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.582072 | 0.235 |
| R-HSA-1483191 | Synthesis of PC | 0.582072 | 0.235 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.585081 | 0.233 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.585081 | 0.233 |
| R-HSA-9634597 | GPER1 signaling | 0.588661 | 0.230 |
| R-HSA-425410 | Metal ion SLC transporters | 0.588661 | 0.230 |
| R-HSA-70263 | Gluconeogenesis | 0.588661 | 0.230 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.589445 | 0.230 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.589445 | 0.230 |
| R-HSA-1638074 | Keratan sulfate/keratin metabolism | 0.595146 | 0.225 |
| R-HSA-9766229 | Degradation of CDH1 | 0.595146 | 0.225 |
| R-HSA-73893 | DNA Damage Bypass | 0.595146 | 0.225 |
| R-HSA-109704 | PI3K Cascade | 0.601529 | 0.221 |
| R-HSA-9748787 | Azathioprine ADME | 0.601529 | 0.221 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.602334 | 0.220 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.611665 | 0.213 |
| R-HSA-72187 | mRNA 3'-end processing | 0.613996 | 0.212 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.613996 | 0.212 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.613996 | 0.212 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.618540 | 0.209 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.620083 | 0.208 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.620083 | 0.208 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 0.626075 | 0.203 |
| R-HSA-73886 | Chromosome Maintenance | 0.631217 | 0.200 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 0.631217 | 0.200 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.631972 | 0.199 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.634173 | 0.198 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.637777 | 0.195 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.637777 | 0.195 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.637777 | 0.195 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.637803 | 0.195 |
| R-HSA-112399 | IRS-mediated signalling | 0.643490 | 0.191 |
| R-HSA-1483166 | Synthesis of PA | 0.643490 | 0.191 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.649114 | 0.188 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.649114 | 0.188 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.650832 | 0.187 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.650832 | 0.187 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.650832 | 0.187 |
| R-HSA-69206 | G1/S Transition | 0.650832 | 0.187 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.654650 | 0.184 |
| R-HSA-191859 | snRNP Assembly | 0.654650 | 0.184 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 0.654650 | 0.184 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.654650 | 0.184 |
| R-HSA-114608 | Platelet degranulation | 0.658444 | 0.181 |
| R-HSA-983189 | Kinesins | 0.660098 | 0.180 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.660098 | 0.180 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.660098 | 0.180 |
| R-HSA-9609690 | HCMV Early Events | 0.662973 | 0.179 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.665461 | 0.177 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.665461 | 0.177 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.665461 | 0.177 |
| R-HSA-450294 | MAP kinase activation | 0.665461 | 0.177 |
| R-HSA-1268020 | Mitochondrial protein import | 0.670739 | 0.173 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.670739 | 0.173 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.670739 | 0.173 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.670739 | 0.173 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.670739 | 0.173 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.675075 | 0.171 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.675935 | 0.170 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.675935 | 0.170 |
| R-HSA-8848021 | Signaling by PTK6 | 0.675935 | 0.170 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.675935 | 0.170 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.681049 | 0.167 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.681049 | 0.167 |
| R-HSA-5690714 | CD22 mediated BCR regulation | 0.681049 | 0.167 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.683941 | 0.165 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.684044 | 0.165 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.686082 | 0.164 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.691037 | 0.160 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.695913 | 0.157 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 0.695913 | 0.157 |
| R-HSA-5218859 | Regulated Necrosis | 0.700713 | 0.154 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.704722 | 0.152 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.704722 | 0.152 |
| R-HSA-448424 | Interleukin-17 signaling | 0.710087 | 0.149 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.710087 | 0.149 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 0.710087 | 0.149 |
| R-HSA-397014 | Muscle contraction | 0.712194 | 0.147 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.714664 | 0.146 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.714664 | 0.146 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.714664 | 0.146 |
| R-HSA-8978934 | Metabolism of cofactors | 0.714664 | 0.146 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.719169 | 0.143 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.719169 | 0.143 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.719169 | 0.143 |
| R-HSA-73894 | DNA Repair | 0.720486 | 0.142 |
| R-HSA-4086398 | Ca2+ pathway | 0.723603 | 0.140 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.727967 | 0.138 |
| R-HSA-8852135 | Protein ubiquitination | 0.732263 | 0.135 |
| R-HSA-9824446 | Viral Infection Pathways | 0.736211 | 0.133 |
| R-HSA-5689603 | UCH proteinases | 0.736491 | 0.133 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.740653 | 0.130 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.740653 | 0.130 |
| R-HSA-6783783 | Interleukin-10 signaling | 0.744749 | 0.128 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.748437 | 0.126 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.748617 | 0.126 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 0.748781 | 0.126 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.751528 | 0.124 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.752749 | 0.123 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.752749 | 0.123 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.752749 | 0.123 |
| R-HSA-977225 | Amyloid fiber formation | 0.756655 | 0.121 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.757263 | 0.121 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.758100 | 0.120 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.760499 | 0.119 |
| R-HSA-72312 | rRNA processing | 0.762818 | 0.118 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.764283 | 0.117 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.767462 | 0.115 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.768007 | 0.115 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.768007 | 0.115 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.768393 | 0.114 |
| R-HSA-9711097 | Cellular response to starvation | 0.768393 | 0.114 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.773790 | 0.111 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.780876 | 0.107 |
| R-HSA-70268 | Pyruvate metabolism | 0.782327 | 0.107 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.784256 | 0.106 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.792487 | 0.101 |
| R-HSA-73884 | Base Excision Repair | 0.792487 | 0.101 |
| R-HSA-8957322 | Metabolism of steroids | 0.795332 | 0.099 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.795767 | 0.099 |
| R-HSA-4839726 | Chromatin organization | 0.799978 | 0.097 |
| R-HSA-9609646 | HCMV Infection | 0.802004 | 0.096 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.802173 | 0.096 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.802173 | 0.096 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.802173 | 0.096 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.803922 | 0.095 |
| R-HSA-2029481 | FCGR activation | 0.805301 | 0.094 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.806266 | 0.094 |
| R-HSA-1474244 | Extracellular matrix organization | 0.807921 | 0.093 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.808380 | 0.092 |
| R-HSA-1474290 | Collagen formation | 0.808380 | 0.092 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.808584 | 0.092 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.808584 | 0.092 |
| R-HSA-5688426 | Deubiquitination | 0.811881 | 0.091 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.817327 | 0.088 |
| R-HSA-157579 | Telomere Maintenance | 0.820216 | 0.086 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.820216 | 0.086 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.823060 | 0.085 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.823060 | 0.085 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.823060 | 0.085 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.823060 | 0.085 |
| R-HSA-190236 | Signaling by FGFR | 0.823060 | 0.085 |
| R-HSA-1643685 | Disease | 0.824304 | 0.084 |
| R-HSA-5663205 | Infectious disease | 0.824873 | 0.084 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 0.825859 | 0.083 |
| R-HSA-416476 | G alpha (q) signalling events | 0.828613 | 0.082 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.830447 | 0.081 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.832183 | 0.080 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.833993 | 0.079 |
| R-HSA-111885 | Opioid Signalling | 0.839205 | 0.076 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.839205 | 0.076 |
| R-HSA-983712 | Ion channel transport | 0.842463 | 0.074 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.844253 | 0.074 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.851532 | 0.070 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.853677 | 0.069 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 0.856195 | 0.067 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.859036 | 0.066 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.860712 | 0.065 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.865087 | 0.063 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.867224 | 0.062 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.869326 | 0.061 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.871395 | 0.060 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.874441 | 0.058 |
| R-HSA-8953854 | Metabolism of RNA | 0.874617 | 0.058 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.875437 | 0.058 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.879352 | 0.056 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.879352 | 0.056 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.879352 | 0.056 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.883144 | 0.054 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.883185 | 0.054 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.884995 | 0.053 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.884995 | 0.053 |
| R-HSA-388396 | GPCR downstream signalling | 0.886049 | 0.053 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.886817 | 0.052 |
| R-HSA-112316 | Neuronal System | 0.888434 | 0.051 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.888611 | 0.051 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.888611 | 0.051 |
| R-HSA-977606 | Regulation of Complement cascade | 0.890376 | 0.050 |
| R-HSA-372790 | Signaling by GPCR | 0.892603 | 0.049 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.893823 | 0.049 |
| R-HSA-8951664 | Neddylation | 0.895778 | 0.048 |
| R-HSA-9843745 | Adipogenesis | 0.903529 | 0.044 |
| R-HSA-5576891 | Cardiac conduction | 0.903529 | 0.044 |
| R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 0.903529 | 0.044 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.905059 | 0.043 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.905902 | 0.043 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.909668 | 0.041 |
| R-HSA-157118 | Signaling by NOTCH | 0.918334 | 0.037 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.921634 | 0.035 |
| R-HSA-166658 | Complement cascade | 0.925305 | 0.034 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.931048 | 0.031 |
| R-HSA-9609507 | Protein localization | 0.934281 | 0.030 |
| R-HSA-1989781 | PPARA activates gene expression | 0.936351 | 0.029 |
| R-HSA-9610379 | HCMV Late Events | 0.938357 | 0.028 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.938357 | 0.028 |
| R-HSA-162587 | HIV Life Cycle | 0.938357 | 0.028 |
| R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 0.938357 | 0.028 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.943379 | 0.025 |
| R-HSA-72306 | tRNA processing | 0.950739 | 0.022 |
| R-HSA-418555 | G alpha (s) signalling events | 0.951522 | 0.022 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.953051 | 0.021 |
| R-HSA-3781865 | Diseases of glycosylation | 0.960642 | 0.017 |
| R-HSA-375276 | Peptide ligand-binding receptors | 0.961884 | 0.017 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.962346 | 0.017 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 0.965933 | 0.015 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.966476 | 0.015 |
| R-HSA-418594 | G alpha (i) signalling events | 0.966635 | 0.015 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.970985 | 0.013 |
| R-HSA-72172 | mRNA Splicing | 0.971902 | 0.012 |
| R-HSA-6805567 | Keratinization | 0.972790 | 0.012 |
| R-HSA-72766 | Translation | 0.974507 | 0.011 |
| R-HSA-9748784 | Drug ADME | 0.977562 | 0.010 |
| R-HSA-162906 | HIV Infection | 0.980585 | 0.009 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.983728 | 0.007 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.990056 | 0.004 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.991462 | 0.004 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.991488 | 0.004 |
| R-HSA-597592 | Post-translational protein modification | 0.992190 | 0.003 |
| R-HSA-5668914 | Diseases of metabolism | 0.993774 | 0.003 |
| R-HSA-556833 | Metabolism of lipids | 0.995854 | 0.002 |
| R-HSA-382551 | Transport of small molecules | 0.996459 | 0.002 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.996916 | 0.001 |
| R-HSA-74160 | Gene expression (Transcription) | 0.997840 | 0.001 |
| R-HSA-8978868 | Fatty acid metabolism | 0.998961 | 0.000 |
| R-HSA-500792 | GPCR ligand binding | 0.999416 | 0.000 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.999446 | 0.000 |
| R-HSA-392499 | Metabolism of proteins | 0.999640 | 0.000 |
| R-HSA-211859 | Biological oxidations | 0.999844 | 0.000 |
| R-HSA-212436 | Generic Transcription Pathway | 0.999865 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999989 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
IKKE |
0.810 | 0.423 | 1 | 0.364 |
TBK1 |
0.810 | 0.393 | 1 | 0.335 |
RAF1 |
0.800 | 0.345 | 1 | 0.267 |
COT |
0.799 | 0.032 | 2 | 0.841 |
IKKB |
0.797 | 0.164 | -2 | 0.795 |
MTOR |
0.795 | 0.096 | 1 | 0.194 |
MST4 |
0.791 | 0.143 | 2 | 0.809 |
MARK4 |
0.791 | 0.152 | 4 | 0.926 |
CLK3 |
0.790 | 0.034 | 1 | 0.093 |
CDC7 |
0.788 | -0.056 | 1 | 0.094 |
BCKDK |
0.788 | 0.205 | -1 | 0.784 |
DSTYK |
0.788 | 0.069 | 2 | 0.867 |
PDHK1 |
0.788 | 0.258 | 1 | 0.270 |
WNK1 |
0.787 | 0.103 | -2 | 0.918 |
AMPKA1 |
0.787 | 0.097 | -3 | 0.823 |
DNAPK |
0.786 | 0.152 | 1 | 0.282 |
CAMK1B |
0.785 | 0.043 | -3 | 0.829 |
PDHK4 |
0.785 | 0.127 | 1 | 0.217 |
QSK |
0.785 | 0.155 | 4 | 0.925 |
PKN2 |
0.784 | 0.077 | -3 | 0.816 |
PRKD2 |
0.784 | 0.068 | -3 | 0.723 |
KIS |
0.784 | -0.012 | 1 | 0.079 |
PIM3 |
0.783 | -0.008 | -3 | 0.803 |
PKACG |
0.783 | 0.110 | -2 | 0.856 |
PRKD1 |
0.783 | 0.045 | -3 | 0.778 |
AURC |
0.782 | 0.131 | -2 | 0.798 |
MARK3 |
0.782 | 0.170 | 4 | 0.911 |
AMPKA2 |
0.782 | 0.081 | -3 | 0.792 |
NDR1 |
0.782 | 0.037 | -3 | 0.808 |
PRPK |
0.782 | -0.050 | -1 | 0.817 |
GCN2 |
0.781 | -0.120 | 2 | 0.765 |
NDR2 |
0.781 | -0.006 | -3 | 0.811 |
MOS |
0.781 | -0.057 | 1 | 0.101 |
IKKA |
0.781 | 0.078 | -2 | 0.772 |
PKN3 |
0.781 | 0.019 | -3 | 0.789 |
RSK2 |
0.780 | 0.048 | -3 | 0.733 |
NLK |
0.780 | -0.004 | 1 | 0.143 |
SIK |
0.780 | 0.113 | -3 | 0.725 |
HUNK |
0.780 | 0.009 | 2 | 0.778 |
HIPK4 |
0.779 | 0.005 | 1 | 0.104 |
ULK2 |
0.779 | -0.048 | 2 | 0.739 |
TSSK1 |
0.779 | 0.093 | -3 | 0.834 |
PKCD |
0.779 | 0.073 | 2 | 0.755 |
PAK6 |
0.779 | 0.148 | -2 | 0.845 |
WNK3 |
0.779 | 0.092 | 1 | 0.211 |
ATR |
0.778 | -0.040 | 1 | 0.127 |
NUAK2 |
0.778 | 0.020 | -3 | 0.805 |
CAMK2G |
0.778 | -0.017 | 2 | 0.797 |
NIK |
0.778 | 0.066 | -3 | 0.850 |
SKMLCK |
0.778 | 0.042 | -2 | 0.931 |
RSK3 |
0.778 | 0.044 | -3 | 0.722 |
SRPK1 |
0.778 | 0.016 | -3 | 0.712 |
NEK6 |
0.778 | -0.026 | -2 | 0.872 |
NEK7 |
0.777 | -0.013 | -3 | 0.798 |
MARK2 |
0.777 | 0.159 | 4 | 0.882 |
CAMLCK |
0.777 | 0.072 | -2 | 0.931 |
QIK |
0.777 | 0.100 | -3 | 0.798 |
MAPKAPK3 |
0.777 | 0.024 | -3 | 0.745 |
PIM1 |
0.776 | 0.024 | -3 | 0.763 |
TSSK2 |
0.776 | 0.064 | -5 | 0.883 |
BMPR2 |
0.776 | -0.036 | -2 | 0.884 |
PKACB |
0.775 | 0.112 | -2 | 0.812 |
NIM1 |
0.775 | 0.033 | 3 | 0.777 |
YSK4 |
0.775 | 0.201 | 1 | 0.262 |
CAMK2D |
0.775 | 0.041 | -3 | 0.803 |
AURB |
0.775 | 0.143 | -2 | 0.803 |
P70S6KB |
0.775 | 0.049 | -3 | 0.765 |
RIPK3 |
0.774 | -0.018 | 3 | 0.703 |
BRSK1 |
0.774 | 0.070 | -3 | 0.752 |
PAK3 |
0.774 | 0.082 | -2 | 0.885 |
AURA |
0.774 | 0.156 | -2 | 0.784 |
MARK1 |
0.774 | 0.150 | 4 | 0.913 |
CHAK2 |
0.774 | -0.001 | -1 | 0.797 |
MNK2 |
0.774 | 0.082 | -2 | 0.899 |
PAK1 |
0.774 | 0.077 | -2 | 0.886 |
CDKL1 |
0.773 | -0.012 | -3 | 0.767 |
P90RSK |
0.773 | 0.023 | -3 | 0.729 |
ERK5 |
0.773 | -0.076 | 1 | 0.101 |
BRSK2 |
0.772 | 0.068 | -3 | 0.781 |
JNK2 |
0.772 | -0.013 | 1 | 0.091 |
MAPKAPK2 |
0.772 | -0.000 | -3 | 0.704 |
MSK1 |
0.772 | 0.091 | -3 | 0.724 |
DAPK2 |
0.772 | 0.022 | -3 | 0.830 |
ATM |
0.771 | -0.037 | 1 | 0.116 |
CAMK4 |
0.771 | 0.011 | -3 | 0.797 |
TGFBR2 |
0.771 | -0.005 | -2 | 0.776 |
GRK1 |
0.771 | 0.023 | -2 | 0.789 |
SRPK2 |
0.771 | 0.022 | -3 | 0.641 |
GRK6 |
0.771 | -0.007 | 1 | 0.133 |
MSK2 |
0.771 | 0.045 | -3 | 0.713 |
LATS2 |
0.771 | 0.002 | -5 | 0.760 |
DYRK2 |
0.770 | -0.027 | 1 | 0.070 |
SGK3 |
0.770 | 0.097 | -3 | 0.740 |
MLK1 |
0.770 | -0.045 | 2 | 0.776 |
CDK8 |
0.769 | -0.066 | 1 | 0.071 |
ULK1 |
0.769 | -0.069 | -3 | 0.779 |
CDKL5 |
0.769 | -0.028 | -3 | 0.759 |
NEK2 |
0.769 | 0.114 | 2 | 0.777 |
NEK9 |
0.769 | -0.005 | 2 | 0.792 |
MELK |
0.769 | 0.014 | -3 | 0.772 |
MYLK4 |
0.768 | 0.082 | -2 | 0.885 |
PRKD3 |
0.768 | 0.042 | -3 | 0.696 |
CAMK2B |
0.768 | 0.018 | 2 | 0.773 |
FAM20C |
0.768 | 0.016 | 2 | 0.625 |
PKG2 |
0.768 | 0.106 | -2 | 0.803 |
CDK7 |
0.768 | -0.053 | 1 | 0.076 |
CLK4 |
0.767 | 0.055 | -3 | 0.734 |
PKCA |
0.767 | 0.068 | 2 | 0.699 |
DLK |
0.767 | -0.026 | 1 | 0.153 |
GRK5 |
0.767 | -0.098 | -3 | 0.862 |
CDK19 |
0.767 | -0.061 | 1 | 0.067 |
ANKRD3 |
0.767 | 0.030 | 1 | 0.175 |
CLK1 |
0.767 | 0.050 | -3 | 0.705 |
PAK2 |
0.767 | 0.085 | -2 | 0.877 |
CDK18 |
0.767 | -0.046 | 1 | 0.052 |
BMPR1B |
0.767 | -0.023 | 1 | 0.071 |
RSK4 |
0.767 | 0.056 | -3 | 0.702 |
HIPK2 |
0.766 | -0.015 | 1 | 0.051 |
CDK1 |
0.766 | -0.046 | 1 | 0.056 |
PKCG |
0.766 | 0.045 | 2 | 0.710 |
PHKG1 |
0.766 | 0.016 | -3 | 0.794 |
NUAK1 |
0.766 | 0.002 | -3 | 0.757 |
P38G |
0.766 | -0.042 | 1 | 0.049 |
ICK |
0.766 | -0.008 | -3 | 0.798 |
CLK2 |
0.766 | 0.052 | -3 | 0.714 |
LATS1 |
0.766 | 0.074 | -3 | 0.819 |
TTBK2 |
0.766 | -0.005 | 2 | 0.673 |
PRKX |
0.765 | 0.087 | -3 | 0.653 |
PKCB |
0.765 | 0.009 | 2 | 0.709 |
CDK17 |
0.765 | -0.054 | 1 | 0.045 |
RIPK1 |
0.764 | -0.073 | 1 | 0.133 |
MASTL |
0.763 | -0.094 | -2 | 0.848 |
CAMK2A |
0.763 | 0.013 | 2 | 0.798 |
AKT2 |
0.763 | 0.068 | -3 | 0.652 |
P38B |
0.763 | -0.035 | 1 | 0.072 |
SRPK3 |
0.763 | 0.019 | -3 | 0.691 |
PHKG2 |
0.763 | 0.079 | -3 | 0.763 |
JNK3 |
0.762 | -0.040 | 1 | 0.079 |
PAK5 |
0.762 | 0.120 | -2 | 0.789 |
PLK1 |
0.762 | -0.008 | -2 | 0.813 |
MNK1 |
0.762 | 0.046 | -2 | 0.897 |
IRE1 |
0.762 | -0.078 | 1 | 0.118 |
MLK2 |
0.762 | -0.085 | 2 | 0.784 |
PKCH |
0.762 | 0.030 | 2 | 0.687 |
GRK4 |
0.762 | -0.052 | -2 | 0.819 |
DYRK4 |
0.762 | -0.017 | 1 | 0.052 |
CDK13 |
0.761 | -0.063 | 1 | 0.078 |
PKACA |
0.761 | 0.112 | -2 | 0.768 |
P38A |
0.761 | -0.040 | 1 | 0.086 |
SSTK |
0.760 | 0.087 | 4 | 0.895 |
PLK4 |
0.760 | 0.040 | 2 | 0.579 |
CAMK1G |
0.760 | 0.002 | -3 | 0.723 |
PKR |
0.760 | -0.002 | 1 | 0.153 |
MST3 |
0.760 | 0.131 | 2 | 0.811 |
CHK1 |
0.760 | 0.019 | -3 | 0.805 |
CDK5 |
0.760 | -0.052 | 1 | 0.068 |
TGFBR1 |
0.760 | -0.043 | -2 | 0.766 |
AKT1 |
0.760 | 0.093 | -3 | 0.673 |
HIPK1 |
0.760 | -0.009 | 1 | 0.074 |
ALK4 |
0.759 | -0.037 | -2 | 0.803 |
HPK1 |
0.759 | 0.365 | 1 | 0.347 |
MLK3 |
0.759 | -0.058 | 2 | 0.715 |
MEK1 |
0.759 | -0.002 | 2 | 0.811 |
PLK3 |
0.759 | -0.014 | 2 | 0.755 |
CHAK1 |
0.759 | -0.013 | 2 | 0.748 |
ERK1 |
0.759 | -0.049 | 1 | 0.082 |
IRE2 |
0.758 | -0.054 | 2 | 0.702 |
PKCZ |
0.758 | -0.017 | 2 | 0.744 |
TLK2 |
0.758 | 0.014 | 1 | 0.196 |
CDK14 |
0.758 | -0.028 | 1 | 0.081 |
CDK16 |
0.758 | -0.038 | 1 | 0.048 |
SMG1 |
0.757 | -0.058 | 1 | 0.133 |
PAK4 |
0.757 | 0.114 | -2 | 0.798 |
WNK4 |
0.757 | 0.059 | -2 | 0.906 |
SNRK |
0.757 | -0.019 | 2 | 0.641 |
TLK1 |
0.757 | 0.059 | -2 | 0.810 |
GRK7 |
0.757 | -0.020 | 1 | 0.106 |
PIM2 |
0.757 | 0.027 | -3 | 0.712 |
GCK |
0.757 | 0.316 | 1 | 0.308 |
CDK12 |
0.757 | -0.058 | 1 | 0.078 |
DYRK1B |
0.757 | -0.023 | 1 | 0.055 |
CDK10 |
0.756 | -0.018 | 1 | 0.068 |
PKCT |
0.756 | 0.044 | 2 | 0.691 |
P38D |
0.755 | -0.037 | 1 | 0.054 |
KHS1 |
0.755 | 0.374 | 1 | 0.364 |
MAPKAPK5 |
0.755 | -0.035 | -3 | 0.691 |
HIPK3 |
0.754 | -0.013 | 1 | 0.103 |
CDK3 |
0.754 | -0.046 | 1 | 0.043 |
KHS2 |
0.754 | 0.341 | 1 | 0.368 |
ZAK |
0.754 | 0.010 | 1 | 0.181 |
MEKK3 |
0.754 | 0.042 | 1 | 0.192 |
CDK9 |
0.754 | -0.069 | 1 | 0.084 |
TAO3 |
0.754 | 0.093 | 1 | 0.207 |
ACVR2B |
0.753 | -0.059 | -2 | 0.775 |
DYRK1A |
0.753 | -0.024 | 1 | 0.093 |
DYRK3 |
0.753 | 0.009 | 1 | 0.074 |
MINK |
0.753 | 0.312 | 1 | 0.317 |
ALK2 |
0.753 | -0.046 | -2 | 0.779 |
DCAMKL1 |
0.752 | -0.011 | -3 | 0.744 |
ERK2 |
0.752 | -0.065 | 1 | 0.086 |
CDK2 |
0.752 | -0.070 | 1 | 0.073 |
MEKK1 |
0.752 | 0.022 | 1 | 0.186 |
ACVR2A |
0.752 | -0.060 | -2 | 0.763 |
MRCKA |
0.751 | 0.143 | -3 | 0.729 |
DRAK1 |
0.751 | -0.099 | 1 | 0.084 |
CK1G1 |
0.751 | 0.115 | -3 | 0.625 |
TNIK |
0.751 | 0.228 | 3 | 0.820 |
NEK11 |
0.750 | 0.118 | 1 | 0.232 |
P70S6K |
0.750 | 0.032 | -3 | 0.680 |
MST2 |
0.750 | 0.208 | 1 | 0.267 |
SMMLCK |
0.750 | 0.047 | -3 | 0.785 |
BRAF |
0.750 | 0.005 | -4 | 0.819 |
CAMK1D |
0.750 | 0.027 | -3 | 0.648 |
VRK2 |
0.750 | -0.147 | 1 | 0.130 |
BMPR1A |
0.749 | -0.043 | 1 | 0.065 |
MRCKB |
0.749 | 0.133 | -3 | 0.708 |
NEK4 |
0.749 | 0.193 | 1 | 0.263 |
MLK4 |
0.749 | -0.084 | 2 | 0.686 |
HRI |
0.749 | -0.052 | -2 | 0.846 |
PKCI |
0.749 | 0.041 | 2 | 0.707 |
HGK |
0.749 | 0.200 | 3 | 0.821 |
MEKK2 |
0.748 | 0.026 | 2 | 0.761 |
NEK5 |
0.748 | -0.007 | 1 | 0.162 |
MEK5 |
0.748 | -0.028 | 2 | 0.785 |
GRK2 |
0.747 | -0.062 | -2 | 0.727 |
LOK |
0.747 | 0.155 | -2 | 0.837 |
AKT3 |
0.746 | 0.077 | -3 | 0.592 |
DCAMKL2 |
0.746 | -0.020 | -3 | 0.764 |
MST1 |
0.746 | 0.235 | 1 | 0.287 |
IRAK4 |
0.746 | -0.053 | 1 | 0.138 |
CK1E |
0.746 | 0.031 | -3 | 0.640 |
PKN1 |
0.746 | 0.027 | -3 | 0.691 |
ROCK2 |
0.745 | 0.129 | -3 | 0.764 |
TAK1 |
0.745 | 0.196 | 1 | 0.248 |
TTBK1 |
0.745 | -0.006 | 2 | 0.594 |
PKCE |
0.744 | 0.042 | 2 | 0.696 |
CAMKK1 |
0.744 | -0.005 | -2 | 0.808 |
SGK1 |
0.744 | 0.073 | -3 | 0.585 |
CAMK1A |
0.743 | 0.042 | -3 | 0.615 |
TAO2 |
0.743 | 0.058 | 2 | 0.814 |
NEK8 |
0.743 | -0.016 | 2 | 0.778 |
DAPK3 |
0.742 | 0.042 | -3 | 0.763 |
PRP4 |
0.742 | -0.050 | -3 | 0.710 |
MPSK1 |
0.742 | -0.056 | 1 | 0.103 |
CK1A2 |
0.742 | 0.064 | -3 | 0.596 |
PERK |
0.742 | -0.093 | -2 | 0.822 |
JNK1 |
0.742 | -0.052 | 1 | 0.069 |
PINK1 |
0.742 | -0.137 | 1 | 0.109 |
SLK |
0.741 | 0.121 | -2 | 0.772 |
CK1D |
0.741 | 0.055 | -3 | 0.597 |
PASK |
0.741 | -0.050 | -3 | 0.818 |
LKB1 |
0.741 | 0.012 | -3 | 0.791 |
CAMKK2 |
0.741 | 0.007 | -2 | 0.812 |
CK2A2 |
0.740 | -0.054 | 1 | 0.045 |
CHK2 |
0.740 | 0.042 | -3 | 0.600 |
MEKK6 |
0.739 | 0.040 | 1 | 0.188 |
MAP3K15 |
0.739 | 0.049 | 1 | 0.194 |
CDK4 |
0.739 | -0.051 | 1 | 0.080 |
GAK |
0.739 | -0.039 | 1 | 0.110 |
CDK6 |
0.739 | -0.054 | 1 | 0.076 |
PDK1 |
0.738 | 0.002 | 1 | 0.174 |
DAPK1 |
0.737 | 0.035 | -3 | 0.749 |
YSK1 |
0.737 | 0.078 | 2 | 0.766 |
ROCK1 |
0.737 | 0.128 | -3 | 0.729 |
PKG1 |
0.737 | 0.091 | -2 | 0.724 |
IRAK1 |
0.737 | -0.059 | -1 | 0.708 |
NEK1 |
0.737 | 0.059 | 1 | 0.183 |
DMPK1 |
0.733 | 0.096 | -3 | 0.726 |
RIPK2 |
0.733 | -0.028 | 1 | 0.197 |
GRK3 |
0.733 | -0.057 | -2 | 0.679 |
MAK |
0.732 | -0.007 | -2 | 0.750 |
ERK7 |
0.732 | -0.038 | 2 | 0.532 |
GSK3B |
0.731 | -0.030 | 4 | 0.383 |
PLK2 |
0.730 | -0.015 | -3 | 0.768 |
CK2A1 |
0.730 | -0.065 | 1 | 0.045 |
EEF2K |
0.730 | -0.024 | 3 | 0.789 |
BUB1 |
0.730 | 0.013 | -5 | 0.845 |
LRRK2 |
0.728 | -0.020 | 2 | 0.809 |
MOK |
0.728 | -0.029 | 1 | 0.054 |
PBK |
0.727 | -0.051 | 1 | 0.102 |
GSK3A |
0.726 | -0.045 | 4 | 0.390 |
CRIK |
0.726 | 0.060 | -3 | 0.671 |
STK33 |
0.726 | -0.075 | 2 | 0.589 |
NEK3 |
0.725 | -0.007 | 1 | 0.187 |
MEK2 |
0.725 | -0.016 | 2 | 0.767 |
VRK1 |
0.724 | -0.112 | 2 | 0.789 |
SBK |
0.724 | 0.013 | -3 | 0.533 |
MYO3A |
0.724 | 0.140 | 1 | 0.264 |
TAO1 |
0.722 | 0.076 | 1 | 0.240 |
MYO3B |
0.721 | 0.068 | 2 | 0.790 |
OSR1 |
0.721 | 0.000 | 2 | 0.755 |
HASPIN |
0.720 | -0.022 | -1 | 0.655 |
PDHK3_TYR |
0.716 | 0.016 | 4 | 0.860 |
ASK1 |
0.716 | 0.014 | 1 | 0.188 |
BIKE |
0.714 | -0.065 | 1 | 0.079 |
RET |
0.714 | 0.114 | 1 | 0.184 |
NEK10_TYR |
0.713 | 0.139 | 1 | 0.234 |
TTK |
0.713 | -0.014 | -2 | 0.811 |
BMPR2_TYR |
0.710 | 0.030 | -1 | 0.866 |
TESK1_TYR |
0.710 | -0.045 | 3 | 0.858 |
PDHK4_TYR |
0.710 | -0.015 | 2 | 0.858 |
YANK3 |
0.710 | -0.018 | 2 | 0.396 |
STLK3 |
0.710 | 0.023 | 1 | 0.206 |
MAP2K7_TYR |
0.709 | -0.006 | 2 | 0.829 |
MAP2K4_TYR |
0.709 | -0.053 | -1 | 0.847 |
TYK2 |
0.709 | 0.115 | 1 | 0.203 |
MAP2K6_TYR |
0.707 | -0.055 | -1 | 0.855 |
LIMK2_TYR |
0.706 | -0.026 | -3 | 0.856 |
JAK2 |
0.706 | 0.089 | 1 | 0.200 |
PDHK1_TYR |
0.706 | -0.036 | -1 | 0.874 |
AAK1 |
0.705 | -0.049 | 1 | 0.059 |
MST1R |
0.704 | 0.035 | 3 | 0.766 |
EPHA6 |
0.704 | -0.007 | -1 | 0.862 |
JAK1 |
0.704 | 0.140 | 1 | 0.237 |
ALPHAK3 |
0.704 | -0.076 | -1 | 0.759 |
PINK1_TYR |
0.704 | -0.121 | 1 | 0.119 |
JAK3 |
0.703 | -0.005 | 1 | 0.132 |
PKMYT1_TYR |
0.703 | -0.119 | 3 | 0.821 |
CSF1R |
0.701 | 0.010 | 3 | 0.749 |
EPHB4 |
0.700 | -0.040 | -1 | 0.831 |
CK1A |
0.700 | 0.012 | -3 | 0.515 |
ROS1 |
0.700 | 0.029 | 3 | 0.733 |
INSRR |
0.698 | 0.007 | 3 | 0.707 |
ABL2 |
0.698 | -0.027 | -1 | 0.779 |
DDR1 |
0.696 | -0.077 | 4 | 0.796 |
LIMK1_TYR |
0.696 | -0.126 | 2 | 0.814 |
KDR |
0.695 | -0.003 | 3 | 0.719 |
FGFR2 |
0.695 | -0.049 | 3 | 0.759 |
TYRO3 |
0.695 | -0.085 | 3 | 0.761 |
TXK |
0.695 | -0.071 | 1 | 0.069 |
CK1G3 |
0.694 | 0.086 | -3 | 0.467 |
ABL1 |
0.694 | -0.044 | -1 | 0.768 |
FLT3 |
0.694 | -0.022 | 3 | 0.760 |
KIT |
0.693 | -0.022 | 3 | 0.755 |
FGR |
0.693 | -0.091 | 1 | 0.108 |
TNNI3K_TYR |
0.693 | -0.022 | 1 | 0.135 |
EPHB1 |
0.692 | -0.065 | 1 | 0.116 |
PDGFRB |
0.691 | -0.076 | 3 | 0.770 |
EPHA4 |
0.691 | -0.053 | 2 | 0.766 |
YES1 |
0.691 | -0.093 | -1 | 0.795 |
FGFR1 |
0.691 | -0.059 | 3 | 0.728 |
FLT1 |
0.690 | -0.021 | -1 | 0.844 |
EPHB2 |
0.690 | -0.057 | -1 | 0.821 |
TNK1 |
0.689 | -0.029 | 3 | 0.748 |
EPHB3 |
0.689 | -0.072 | -1 | 0.814 |
LCK |
0.689 | -0.043 | -1 | 0.798 |
FER |
0.688 | -0.131 | 1 | 0.110 |
HCK |
0.688 | -0.070 | -1 | 0.790 |
ERBB2 |
0.688 | -0.026 | 1 | 0.161 |
PDGFRA |
0.687 | -0.048 | 3 | 0.762 |
BLK |
0.686 | -0.057 | -1 | 0.812 |
ITK |
0.686 | -0.104 | -1 | 0.753 |
SRMS |
0.686 | -0.111 | 1 | 0.111 |
TNK2 |
0.685 | -0.098 | 3 | 0.716 |
TEK |
0.685 | -0.064 | 3 | 0.695 |
FGFR3 |
0.685 | -0.048 | 3 | 0.726 |
MET |
0.684 | -0.076 | 3 | 0.745 |
FRK |
0.683 | -0.028 | -1 | 0.812 |
EGFR |
0.683 | -0.052 | 1 | 0.102 |
ALK |
0.683 | -0.035 | 3 | 0.684 |
EPHA7 |
0.683 | -0.057 | 2 | 0.761 |
AXL |
0.683 | -0.094 | 3 | 0.734 |
FLT4 |
0.682 | -0.060 | 3 | 0.710 |
DDR2 |
0.682 | -0.045 | 3 | 0.691 |
MERTK |
0.682 | -0.100 | 3 | 0.738 |
BMX |
0.682 | -0.073 | -1 | 0.681 |
LTK |
0.681 | -0.062 | 3 | 0.707 |
NTRK1 |
0.680 | -0.091 | -1 | 0.792 |
BTK |
0.680 | -0.092 | -1 | 0.702 |
EPHA1 |
0.680 | -0.044 | 3 | 0.719 |
TEC |
0.679 | -0.080 | -1 | 0.681 |
FYN |
0.679 | -0.053 | -1 | 0.775 |
EPHA3 |
0.679 | -0.066 | 2 | 0.732 |
INSR |
0.679 | -0.074 | 3 | 0.676 |
YANK2 |
0.679 | -0.027 | 2 | 0.414 |
WEE1_TYR |
0.677 | -0.085 | -1 | 0.698 |
EPHA5 |
0.677 | -0.061 | 2 | 0.749 |
NTRK2 |
0.676 | -0.106 | 3 | 0.708 |
FGFR4 |
0.676 | -0.031 | -1 | 0.765 |
PTK2 |
0.674 | -0.024 | -1 | 0.815 |
EPHA8 |
0.673 | -0.071 | -1 | 0.805 |
SYK |
0.673 | -0.023 | -1 | 0.797 |
NTRK3 |
0.673 | -0.113 | -1 | 0.747 |
MATK |
0.672 | -0.082 | -1 | 0.725 |
PTK6 |
0.672 | -0.134 | -1 | 0.671 |
LYN |
0.671 | -0.084 | 3 | 0.674 |
MUSK |
0.670 | -0.095 | 1 | 0.099 |
CSK |
0.670 | -0.081 | 2 | 0.759 |
ERBB4 |
0.669 | -0.047 | 1 | 0.096 |
PTK2B |
0.668 | -0.125 | -1 | 0.729 |
EPHA2 |
0.668 | -0.060 | -1 | 0.785 |
SRC |
0.667 | -0.103 | -1 | 0.768 |
CK1G2 |
0.666 | 0.022 | -3 | 0.552 |
IGF1R |
0.665 | -0.073 | 3 | 0.621 |
ZAP70 |
0.661 | -0.031 | -1 | 0.707 |
FES |
0.643 | -0.128 | -1 | 0.659 |