Motif 843 (n=242)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A1L020 | MEX3A | S338 | ochoa | RNA-binding protein MEX3A (RING finger and KH domain-containing protein 4) | RNA binding protein, may be involved in post-transcriptional regulatory mechanisms. |
| A1L0T0 | ILVBL | S167 | ochoa | 2-hydroxyacyl-CoA lyase 2 (EC 4.1.2.-) (Acetolactate synthase-like protein) (IlvB-like protein) | Endoplasmic reticulum 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner. Involved in the phytosphingosine degradation pathway. {ECO:0000269|PubMed:28289220}. |
| A2RU30 | TESPA1 | S454 | ochoa | Protein TESPA1 (Thymocyte-expressed positive selection-associated protein 1) | Required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development (By similarity). Plays a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes. May play a role in the regulation of inositol 1,4,5-trisphosphate receptor-mediated Ca(2+) release and mitochondrial Ca(2+) uptake via the mitochondria-associated endoplasmic reticulum membrane (MAM) compartment. {ECO:0000250, ECO:0000269|PubMed:22561606}. |
| A6NC98 | CCDC88B | S429 | ochoa | Coiled-coil domain-containing protein 88B (Brain leucine zipper domain-containing protein) (Gipie) (Hook-related protein 3) (HkRP3) | Acts as a positive regulator of T-cell maturation and inflammatory function. Required for several functions of T-cells, in both the CD4(+) and the CD8(+) compartments and this includes expression of cell surface markers of activation, proliferation, and cytokine production in response to specific or non-specific stimulation (By similarity). Enhances NK cell cytotoxicity by positively regulating polarization of microtubule-organizing center (MTOC) to cytotoxic synapse, lytic granule transport along microtubules, and dynein-mediated clustering to MTOC (PubMed:25762780). Interacts with HSPA5 and stabilizes the interaction between HSPA5 and ERN1, leading to suppression of ERN1-induced JNK activation and endoplasmic reticulum stress-induced apoptosis (PubMed:21289099). {ECO:0000250|UniProtKB:Q4QRL3, ECO:0000269|PubMed:21289099, ECO:0000269|PubMed:25762780}. |
| H7BYZ3 | None | S27 | ochoa | EF-hand domain-containing protein | Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity. {ECO:0000256|ARBA:ARBA00023754}. |
| H7BYZ3 | None | S35 | ochoa | EF-hand domain-containing protein | Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity. {ECO:0000256|ARBA:ARBA00023754}. |
| O14514 | ADGRB1 | S1306 | ochoa | Adhesion G protein-coupled receptor B1 (Brain-specific angiogenesis inhibitor 1) [Cleaved into: Vasculostatin-40 (Vstat40); Vasculostatin-120 (Vstat120)] | Phosphatidylserine receptor which enhances the engulfment of apoptotic cells (PubMed:24509909). Also mediates the binding and engulfment of Gram-negative bacteria (PubMed:26838550). Stimulates production of reactive oxygen species by macrophages in response to Gram-negative bacteria, resulting in enhanced microbicidal macrophage activity (PubMed:26838550). In the gastric mucosa, required for recognition and engulfment of apoptotic gastric epithelial cells (PubMed:24509909). Promotes myoblast fusion (By similarity). Activates the Rho pathway in a G-protein-dependent manner (PubMed:23782696). Inhibits MDM2-mediated ubiquitination and degradation of DLG4/PSD95, promoting DLG4 stability and regulating synaptic plasticity (By similarity). Required for the formation of dendritic spines by ensuring the correct localization of PARD3 and TIAM1 (By similarity). Potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53/TP53 signal in suppression of glioblastoma (PubMed:11875720). {ECO:0000250|UniProtKB:C0HL12, ECO:0000250|UniProtKB:Q3UHD1, ECO:0000269|PubMed:11875720, ECO:0000269|PubMed:23782696, ECO:0000269|PubMed:24509909, ECO:0000269|PubMed:26838550}.; FUNCTION: [Vasculostatin-120]: Inhibits angiogenesis in a CD36-dependent manner. {ECO:0000269|PubMed:15782143, ECO:0000269|PubMed:19176395}.; FUNCTION: [Vasculostatin-40]: Inhibits angiogenesis. {ECO:0000269|PubMed:22330140}. |
| O14523 | C2CD2L | S59 | ochoa | Phospholipid transfer protein C2CD2L (C2 domain-containing protein 2-like) (C2CD2-like) (Transmembrane protein 24) | Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane (PubMed:28209843). It thereby maintains the pool of cell membrane phosphoinositides, which are degraded during phospholipase C (PLC) signaling (PubMed:28209843). Plays a key role in the coordination of Ca(2+) and phosphoinositide signaling: localizes to sites of contact between the endoplasmic reticulum and the cell membrane, where it tethers the two bilayers (PubMed:28209843). In response to elevation of cytosolic Ca(2+), it is phosphorylated at its C-terminus and dissociates from the cell membrane, abolishing phosphatidylinositol transport to the cell membrane (PubMed:28209843). Positively regulates insulin secretion in response to glucose: phosphatidylinositol transfer to the cell membrane allows replenishment of PI(4,5)P2 pools and calcium channel opening, priming a new population of insulin granules (PubMed:28209843). {ECO:0000269|PubMed:28209843}. |
| O15042 | U2SURP | S731 | ochoa | U2 snRNP-associated SURP motif-containing protein (140 kDa Ser/Arg-rich domain protein) (U2-associated protein SR140) | None |
| O15117 | FYB1 | S734 | ochoa | FYN-binding protein 1 (Adhesion and degranulation promoting adaptor protein) (ADAP) (FYB-120/130) (p120/p130) (FYN-T-binding protein) (SLAP-130) (SLP-76-associated phosphoprotein) | Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells (By similarity). May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton (PubMed:10747096, PubMed:16980616). Modulates the expression of IL2 (By similarity). Involved in platelet activation (By similarity). Prevents the degradation of SKAP1 and SKAP2 (PubMed:15849195). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (By similarity). {ECO:0000250|UniProtKB:D3ZIE4, ECO:0000250|UniProtKB:O35601, ECO:0000269|PubMed:10747096, ECO:0000269|PubMed:15849195, ECO:0000269|PubMed:16980616}. |
| O15213 | WDR46 | S528 | ochoa | WD repeat-containing protein 46 (WD repeat-containing protein BING4) | Scaffold component of the nucleolar structure. Required for localization of DDX21 and NCL to the granular compartment of the nucleolus (PubMed:23848194). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23848194, ECO:0000269|PubMed:34516797}. |
| O15304 | SIVA1 | Y53 | psp | Apoptosis regulatory protein Siva (CD27-binding protein) (CD27BP) | Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis. {ECO:0000269|PubMed:12011449, ECO:0000269|PubMed:14739602, ECO:0000269|PubMed:15034012, ECO:0000269|PubMed:15958577, ECO:0000269|PubMed:16491128}. |
| O15519 | CFLAR | S193 | psp | CASP8 and FADD-like apoptosis regulator (Caspase homolog) (CASH) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (Cellular FLICE-like inhibitory protein) (c-FLIP) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Inhibitor of FLICE) (I-FLICE) (MACH-related inducer of toxicity) (MRIT) (Usurpin) [Cleaved into: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12] | Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity. {ECO:0000269|PubMed:9880531}. |
| O15519 | CFLAR | S273 | psp | CASP8 and FADD-like apoptosis regulator (Caspase homolog) (CASH) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (Cellular FLICE-like inhibitory protein) (c-FLIP) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Inhibitor of FLICE) (I-FLICE) (MACH-related inducer of toxicity) (MRIT) (Usurpin) [Cleaved into: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12] | Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity. {ECO:0000269|PubMed:9880531}. |
| O43182 | ARHGAP6 | S384 | ochoa | Rho GTPase-activating protein 6 (Rho-type GTPase-activating protein 6) (Rho-type GTPase-activating protein RhoGAPX-1) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology. {ECO:0000269|PubMed:10699171}. |
| O43194 | GPR39 | S256 | ochoa | G-protein coupled receptor 39 | Zinc-sensing receptor that can sense changes in extracellular Zn(2+), mediate Zn(2+) signal transmission, and participates in the regulation of numerous physiological processes including glucose homeostasis regulation, gastrointestinal mobility, hormone secretion and cell death (PubMed:18180304). Activation by Zn(2+) in keratinocytes increases the intracellular concentration of Ca(2+) and activates the ERK/MAPK and PI3K/AKT signaling pathways leading to epithelial repair (PubMed:20522546). Plays an essential role in normal wound healing by inducing the production of cytokines including the major inflammatory cytokine IL6 via the PKC/MAPK/CEBPB pathway (By similarity). Regulates adipose tissue metabolism, especially lipolysis, and regulates the function of lipases, such as hormone-sensitive lipase and adipose triglyceride lipase (By similarity). Plays a role in the inhibition of cell death and protects against oxidative, endoplasmic reticulum and mitochondrial stress by inducing secretion of the cytoprotective pigment epithelium-derived growth factor (PEDF) and probably other protective transcripts in a GNA13/RHOA/SRE-dependent manner (PubMed:18180304). Forms dynamic heteroreceptor complexes with HTR1A and GALR1 depending on cell type or specific physiological states, resulting in signaling diversity: HTR1A-GPR39 shows additive increase in signaling along the serum response element (SRE) and NF-kappa-B pathways while GALR1 acts as an antagonist blocking SRE (PubMed:26365466). {ECO:0000250|UniProtKB:Q5U431, ECO:0000269|PubMed:18180304, ECO:0000269|PubMed:20522546, ECO:0000269|PubMed:26365466}. |
| O43491 | EPB41L2 | S614 | ochoa | Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) | Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| O43581 | SYT7 | S52 | ochoa | Synaptotagmin-7 (IPCA-7) (Prostate cancer-associated protein 7) (Synaptotagmin VII) (SytVII) | Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory and synaptic vesicles through Ca(2+) and phospholipid binding to the C2 domain (By similarity). Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity). SYT7 binds Ca(2+) with high affinity and slow kinetics compared to other synaptotagmins (By similarity). Involved in Ca(2+)-triggered lysosomal exocytosis, a major component of the plasma membrane repair (PubMed:11342594). Ca(2+)-regulated delivery of lysosomal membranes to the cell surface is also involved in the phagocytic uptake of particles by macrophages (By similarity). Ca(2+)-triggered lysosomal exocytosis also plays a role in bone remodeling by regulating secretory pathways in osteoclasts and osteoblasts (By similarity). In case of infection, involved in participates cell invasion by Trypanosoma cruzi via Ca(2+)-triggered lysosomal exocytosis (PubMed:11342594, PubMed:15811535). Involved in cholesterol transport from lysosome to peroxisome by promoting membrane contacts between lysosomes and peroxisomes: probably acts by promoting vesicle fusion by binding phosphatidylinositol-4,5-bisphosphate on peroxisomal membranes (By similarity). Acts as a key mediator of synaptic facilitation, a process also named short-term synaptic potentiation: synaptic facilitation takes place at synapses with a low initial release probability and is caused by influx of Ca(2+) into the axon terminal after spike generation, increasing the release probability of neurotransmitters (By similarity). Probably mediates synaptic facilitation by directly increasing the probability of release (By similarity). May also contribute to synaptic facilitation by regulating synaptic vesicle replenishment, a process required to ensure that synaptic vesicles are ready for the arrival of the next action potential: SYT7 is required for synaptic vesicle replenishment by acting as a sensor for Ca(2+) and by forming a complex with calmodulin (By similarity). Also acts as a regulator of Ca(2+)-dependent insulin and glucagon secretion in beta-cells (By similarity). Triggers exocytosis by promoting fusion pore opening and fusion pore expansion in chromaffin cells (By similarity). Also regulates the secretion of some non-synaptic secretory granules of specialized cells (By similarity). {ECO:0000250|UniProtKB:Q62747, ECO:0000250|UniProtKB:Q9R0N7, ECO:0000269|PubMed:11342594, ECO:0000269|PubMed:15811535}. |
| O60343 | TBC1D4 | S566 | ochoa | TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160) | May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake. {ECO:0000269|PubMed:15971998, ECO:0000269|PubMed:18771725, ECO:0000269|PubMed:22908308}. |
| O60427 | FADS1 | S87 | ochoa | Acyl-CoA (8-3)-desaturase (EC 1.14.19.44) (Delta(5) fatty acid desaturase) (D5D) (Delta(5) desaturase) (Delta-5 desaturase) (Fatty acid desaturase 1) | [Isoform 1]: Acts as a front-end fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 5 located between a preexisting double bond and the carboxyl end of the fatty acyl chain. Involved in biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors. Specifically, desaturates dihomo-gamma-linoleoate (DGLA) (20:3n-6) and eicosatetraenoate (ETA) (20:4n-3) to generate arachidonate (AA) (20:4n-6) and eicosapentaenoate (EPA) (20:5n-3), respectively (PubMed:10601301, PubMed:10769175). As a rate limiting enzyme for DGLA (20:3n-6) and AA (20:4n-6)-derived eicosanoid biosynthesis, controls the metabolism of inflammatory lipids like prostaglandin E2, critical for efficient acute inflammatory response and maintenance of epithelium homeostasis. Contributes to membrane phospholipid biosynthesis by providing AA (20:4n-6) as a major acyl chain esterified into phospholipids. In particular, regulates phosphatidylinositol-4,5-bisphosphate levels, modulating inflammatory cytokine production in T-cells (By similarity). Also desaturates (11E)-octadecenoate (trans-vaccenoate)(18:1n-9), a metabolite in the biohydrogenation pathway of LA (18:2n-6) (By similarity). {ECO:0000250|UniProtKB:Q920L1, ECO:0000250|UniProtKB:Q920R3, ECO:0000269|PubMed:10601301, ECO:0000269|PubMed:10769175}.; FUNCTION: [Isoform 2]: Does not exhibit any catalytic activity toward 20:3n-6, but it may enhance FADS2 activity. {ECO:0000250|UniProtKB:A4UVI1}. |
| O60447 | EVI5 | S102 | ochoa | Ecotropic viral integration site 5 protein homolog (EVI-5) (Neuroblastoma stage 4S gene protein) | Functions as a regulator of cell cycle progression by stabilizing the FBXO5 protein and promoting cyclin-A accumulation during interphase. May play a role in cytokinesis. {ECO:0000269|PubMed:16439210}. |
| O75153 | CLUH | S649 | ochoa | Clustered mitochondria protein homolog | mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. Specifically binds mRNAs of nuclear-encoded mitochondrial proteins in the cytoplasm and regulates transport or translation of these transcripts close to mitochondria, playing a role in mitochondrial biogenesis. {ECO:0000255|HAMAP-Rule:MF_03013, ECO:0000269|PubMed:25349259}. |
| O75469 | NR1I2 | S274 | psp | Nuclear receptor subfamily 1 group I member 2 (Orphan nuclear receptor PAR1) (Orphan nuclear receptor PXR) (Pregnane X receptor) (Steroid and xenobiotic receptor) (SXR) | Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes. {ECO:0000269|PubMed:11297522, ECO:0000269|PubMed:11668216, ECO:0000269|PubMed:12578355, ECO:0000269|PubMed:18768384, ECO:0000269|PubMed:19297428, ECO:0000269|PubMed:9727070}. |
| O75643 | SNRNP200 | S26 | ochoa | U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.4.13) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog) (U5 snRNP-specific 200 kDa protein) (U5-200KD) | Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome (PubMed:35241646). Plays a role in pre-mRNA splicing as a core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:28502770, PubMed:28781166, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30315277, PubMed:30705154, PubMed:30728453). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. {ECO:0000269|PubMed:16723661, ECO:0000269|PubMed:23045696, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:30728453, ECO:0000269|PubMed:35241646, ECO:0000269|PubMed:8670905, ECO:0000269|PubMed:9539711, ECO:0000305|PubMed:33509932}. |
| O94875 | SORBS2 | S230 | ochoa | Sorbin and SH3 domain-containing protein 2 (Arg-binding protein 2) (ArgBP2) (Arg/Abl-interacting protein 2) (Sorbin) | Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12 (PubMed:18559503). Isoform 6 increases water and sodium absorption in the intestine and gall-bladder. {ECO:0000269|PubMed:12475393, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:9211900}. |
| O95071 | UBR5 | S2011 | ochoa | E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250|UniProtKB:Q80TP3, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:28689657, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:33208877, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37478862}. |
| O95071 | UBR5 | S2437 | ochoa | E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250|UniProtKB:Q80TP3, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:28689657, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:33208877, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37478862}. |
| O95163 | ELP1 | S251 | ochoa | Elongator complex protein 1 (ELP1) (IkappaB kinase complex-associated protein) (IKK complex-associated protein) (p150) | Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:29332244). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244). Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (By similarity). ELP1 binds to tRNA, mediating interaction of the elongator complex with tRNA (By similarity). May act as a scaffold protein that assembles active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK) (PubMed:9751059). {ECO:0000250|UniProtKB:Q06706, ECO:0000250|UniProtKB:Q7TT37, ECO:0000269|PubMed:9751059, ECO:0000303|PubMed:29332244}. |
| O95466 | FMNL1 | S911 | ochoa | Formin-like protein 1 (CLL-associated antigen KW-13) (Leukocyte formin) | May play a role in the control of cell motility and survival of macrophages (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. {ECO:0000250, ECO:0000269|PubMed:21834987}. |
| P02775 | PPBP | S52 | ochoa | Platelet basic protein (PBP) (C-X-C motif chemokine 7) (Leukocyte-derived growth factor) (LDGF) (Macrophage-derived growth factor) (MDGF) (Small-inducible cytokine B7) [Cleaved into: Connective tissue-activating peptide III (CTAP-III) (LA-PF4) (Low-affinity platelet factor IV); TC-2; Connective tissue-activating peptide III(1-81) (CTAP-III(1-81)); Beta-thromboglobulin (Beta-TG); Neutrophil-activating peptide 2(74) (NAP-2(74)); Neutrophil-activating peptide 2(73) (NAP-2(73)); Neutrophil-activating peptide 2 (NAP-2); TC-1; Neutrophil-activating peptide 2(1-66) (NAP-2(1-66)); Neutrophil-activating peptide 2(1-63) (NAP-2(1-63))] | LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III(1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation. {ECO:0000269|PubMed:10877842, ECO:0000269|PubMed:7890771, ECO:0000269|PubMed:8950790, ECO:0000269|PubMed:9794434}. |
| P05783 | KRT18 | S323 | ochoa | Keratin, type I cytoskeletal 18 (Cell proliferation-inducing gene 46 protein) (Cytokeratin-18) (CK-18) (Keratin-18) (K18) | Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. {ECO:0000250, ECO:0000269|PubMed:15529338, ECO:0000269|PubMed:16424149, ECO:0000269|PubMed:17213200, ECO:0000269|PubMed:7523419, ECO:0000269|PubMed:8522591, ECO:0000269|PubMed:9298992, ECO:0000269|PubMed:9524113}. |
| P06732 | CKM | S164 | ochoa | Creatine kinase M-type (EC 2.7.3.2) (Creatine kinase M chain) (Creatine phosphokinase M-type) (CPK-M) (M-CK) | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. {ECO:0000250|UniProtKB:P00563}. |
| P07195 | LDHB | S303 | ochoa | L-lactate dehydrogenase B chain (LDH-B) (EC 1.1.1.27) (LDH heart subunit) (LDH-H) (Renal carcinoma antigen NY-REN-46) | Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). {ECO:0000269|PubMed:27618187}. |
| P08034 | GJB1 | S258 | ochoa | Gap junction beta-1 protein (Connexin-32) (Cx32) (GAP junction 28 kDa liver protein) | One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. |
| P08670 | VIM | S87 | ochoa | Vimentin | Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Plays a role in cell directional movement, orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Protects SCRIB from proteasomal degradation and facilitates its localization to intermediate filaments in a cell contact-mediated manner (By similarity). {ECO:0000250|UniProtKB:A0A8C0N8E3, ECO:0000250|UniProtKB:P31000}.; FUNCTION: Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. {ECO:0000269|PubMed:21746880}. |
| P08670 | VIM | S420 | ochoa | Vimentin | Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Plays a role in cell directional movement, orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Protects SCRIB from proteasomal degradation and facilitates its localization to intermediate filaments in a cell contact-mediated manner (By similarity). {ECO:0000250|UniProtKB:A0A8C0N8E3, ECO:0000250|UniProtKB:P31000}.; FUNCTION: Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. {ECO:0000269|PubMed:21746880}. |
| P08708 | RPS17 | S113 | ochoa | Small ribosomal subunit protein eS17 (40S ribosomal protein S17) | Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| P12277 | CKB | S164 | ochoa | Creatine kinase B-type (EC 2.7.3.2) (Brain creatine kinase) (B-CK) (Creatine kinase B chain) (Creatine phosphokinase B-type) (CPK-B) | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate) (PubMed:8186255). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (Probable). Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle: localizes to the mitochondria of thermogenic fat cells and acts by mediating phosphorylation of creatine to initiate a futile cycle of creatine phosphorylation and dephosphorylation (By similarity). During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N-phosphocreatine as heat without performing any mechanical or chemical work (By similarity). {ECO:0000250|UniProtKB:Q04447, ECO:0000269|PubMed:8186255, ECO:0000305}. |
| P12755 | SKI | S366 | ochoa | Ski oncogene (Proto-oncogene c-Ski) | May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. Functions as a repressor of TGF-beta signaling. {ECO:0000269|PubMed:19049980}. |
| P14136 | GFAP | S38 | psp | Glial fibrillary acidic protein (GFAP) | GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells. |
| P14672 | SLC2A4 | S274 | psp | Solute carrier family 2, facilitated glucose transporter member 4 (Glucose transporter type 4, insulin-responsive) (GLUT-4) | Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation. Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells. Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell. {ECO:0000250|UniProtKB:P19357}. |
| P15259 | PGAM2 | S189 | ochoa | Phosphoglycerate mutase 2 (EC 5.4.2.11) (EC 5.4.2.4) (BPG-dependent PGAM 2) (Muscle-specific phosphoglycerate mutase) (Phosphoglycerate mutase isozyme M) (PGAM-M) | Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase), but with a reduced activity. |
| P16144 | ITGB4 | S1069 | ochoa | Integrin beta-4 (GP150) (CD antigen CD104) | Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:28873464}. |
| P18206 | VCL | S579 | ochoa | Vinculin (Metavinculin) (MV) | Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. {ECO:0000269|PubMed:20484056}. |
| P18669 | PGAM1 | S189 | ochoa | Phosphoglycerate mutase 1 (EC 5.4.2.11) (EC 5.4.2.4) (BPG-dependent PGAM 1) (Phosphoglycerate mutase isozyme B) (PGAM-B) | Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglyceratea crucial step in glycolysis, by using 2,3-bisphosphoglycerate (PubMed:23653202). Also catalyzes the interconversion of (2R)-2,3-bisphosphoglycerate and (2R)-3-phospho-glyceroyl phosphate (PubMed:23653202). {ECO:0000269|PubMed:23653202}. |
| P20290 | BTF3 | S161 | ochoa | Transcription factor BTF3 (Nascent polypeptide-associated complex subunit beta) (NAC-beta) (RNA polymerase B transcription factor 3) | When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription. {ECO:0000269|PubMed:10982809}. |
| P25786 | PSMA1 | S110 | ochoa | Proteasome subunit alpha type-1 (30 kDa prosomal protein) (PROS-30) (Macropain subunit C2) (Multicatalytic endopeptidase complex subunit C2) (Proteasome component C2) (Proteasome nu chain) (Proteasome subunit alpha-6) (alpha-6) | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. |
| P26358 | DNMT1 | S35 | ochoa | DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT) | Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). Promotes tumor growth (PubMed:24623306). {ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18754681, ECO:0000269|PubMed:24623306}. |
| P26358 | DNMT1 | S549 | ochoa | DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT) | Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). Promotes tumor growth (PubMed:24623306). {ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18754681, ECO:0000269|PubMed:24623306}. |
| P27694 | RPA1 | S315 | ochoa | Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed] | As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism (PubMed:17596542, PubMed:27723717, PubMed:27723720). Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (PubMed:9430682). In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response (PubMed:24332808). It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage (PubMed:17765923). Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair (PubMed:7697716). Also plays a role in base excision repair (BER) probably through interaction with UNG (PubMed:9765279). Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. Plays a role in telomere maintenance (PubMed:17959650, PubMed:34767620). As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA synthesis by polymerase delta in presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange (PubMed:19996105). RPA stimulates 5'-3' helicase activity of the BRIP1/FANCJ (PubMed:17596542). {ECO:0000269|PubMed:12791985, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:17765923, ECO:0000269|PubMed:17959650, ECO:0000269|PubMed:19116208, ECO:0000269|PubMed:19996105, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:27723717, ECO:0000269|PubMed:27723720, ECO:0000269|PubMed:34767620, ECO:0000269|PubMed:7697716, ECO:0000269|PubMed:7700386, ECO:0000269|PubMed:9430682, ECO:0000269|PubMed:9765279}. |
| P27986 | PIK3R1 | Y580 | ochoa|psp | Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha) | Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923). {ECO:0000269|PubMed:17626883, ECO:0000269|PubMed:19805105, ECO:0000269|PubMed:20348923, ECO:0000269|PubMed:7518429}. |
| P30084 | ECHS1 | S186 | ochoa | Enoyl-CoA hydratase, mitochondrial (mECH) (mECH1) (EC 4.2.1.17) (EC 5.3.3.8) (Enoyl-CoA hydratase 1) (ECHS1) (Short-chain enoyl-CoA hydratase) (SCEH) | Converts unsaturated trans-2-enoyl-CoA species ((2E)-enoyl-CoA) to the corresponding (3S)-3hydroxyacyl-CoA species through addition of a water molecule to the double bond (PubMed:25125611, PubMed:26251176). Catalyzes the hydration of medium- and short-chained fatty enoyl-CoA thioesters from 4 carbons long (C4) up to C16 (PubMed:26251176). Has high substrate specificity for crotonyl-CoA ((2E)-butenoyl-CoA) and moderate specificity for acryloyl-CoA, 3-methylcrotonyl-CoA (3-methyl-(2E)-butenoyl-CoA) and methacrylyl-CoA ((2E)-2-methylpropenoyl-CoA) (PubMed:26251176). Can bind tiglyl-CoA (2-methylcrotonoyl-CoA), but hydrates only a small amount of this substrate (PubMed:26251176). Plays a key role in the beta-oxidation spiral of short- and medium-chain fatty acid oxidation (PubMed:25125611, PubMed:26251176). At a lower rate than the hydratase reaction, catalyzes the isomerase reaction of trans-3-enoyl-CoA species (such as (3E)-hexenoyl-CoA) to trans-2-enoyl-CoA species (such as (2E)-hexenoyl-CoA), which are subsequently hydrated to 3(S)-3-hydroxyacyl-CoA species (such as (3S)-hydroxyhexanoyl-CoA) (By similarity). {ECO:0000250|UniProtKB:P14604, ECO:0000269|PubMed:25125611, ECO:0000269|PubMed:26251176}. |
| P30307 | CDC25C | S263 | ochoa|psp | M-phase inducer phosphatase 3 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25C) | Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle (PubMed:8119945). When phosphorylated, highly effective in activating G2 cells into prophase (PubMed:8119945). Directly dephosphorylates CDK1 and activates its kinase activity (PubMed:8119945). {ECO:0000269|PubMed:8119945}. |
| P31350 | RRM2 | S26 | ochoa | Ribonucleoside-diphosphate reductase subunit M2 (EC 1.17.4.1) (Ribonucleotide reductase small chain) (Ribonucleotide reductase small subunit) | Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling. |
| P31513 | FMO3 | S195 | ochoa | Flavin-containing monooxygenase 3 (EC 1.14.13.148) (EC 1.14.13.32) (EC 1.14.13.8) (Dimethylaniline monooxygenase [N-oxide-forming] 3) (Dimethylaniline oxidase 3) (FMO II) (FMO form 2) (Hepatic flavin-containing monooxygenase 3) (FMO 3) (Trimethylamine monooxygenase) | Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds (PubMed:10759686, PubMed:30381441, PubMed:32156684). Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite (PubMed:9776311). TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation (PubMed:29981269). {ECO:0000269|PubMed:10759686, ECO:0000269|PubMed:29981269, ECO:0000269|PubMed:30381441, ECO:0000269|PubMed:32156684, ECO:0000269|PubMed:9224773, ECO:0000269|PubMed:9776311}. |
| P32927 | CSF2RB | S601 | ochoa|psp | Cytokine receptor common subunit beta (CDw131) (GM-CSF/IL-3/IL-5 receptor common beta subunit) (CD antigen CD131) | Cell surface receptor that plays a role in immune response and controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Acts by forming an heterodimeric receptor through interaction with different partners such as IL3RA, IL5RA or CSF2RA (PubMed:1495999). In turn, participates in various signaling pathways including interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor/CSF2 pathways. In unstimulated conditions, interacts constitutively with JAK1 and ligand binding leads to JAK1 stimulation and subsequent activation of the JAK-STAT pathway (PubMed:9516124). {ECO:0000269|PubMed:1495999, ECO:0000269|PubMed:9516124}. |
| P35222 | CTNNB1 | S681 | ochoa | Catenin beta-1 (Beta-catenin) | Key downstream component of the canonical Wnt signaling pathway (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). Also acts as a coactivator for other transcription factors, such as NR5A2 (PubMed:22187462). Promotes epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via driving transcription of CTNNB1/TCF-target genes (PubMed:29910125). Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (By similarity). Acts as a negative regulator of centrosome cohesion (PubMed:18086858). Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization (PubMed:21262353). Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (PubMed:18957423). Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity). Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, via promoting the transcription of differentiation factors such as LEF1, BMP2 and BMP4 (By similarity). Activity is repressed in a MSX1-mediated manner at the bell stage of mesenchymal tooth germ formation which prevents premature differentiation of odontoblasts (By similarity). {ECO:0000250|UniProtKB:Q02248, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:18077326, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18957423, ECO:0000269|PubMed:21262353, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22187462, ECO:0000269|PubMed:22647378, ECO:0000269|PubMed:22699938, ECO:0000269|PubMed:29910125}. |
| P35270 | SPR | S103 | ochoa | Sepiapterin reductase (SPR) (EC 1.1.1.153) | Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin. |
| P35408 | PTGER4 | S430 | ochoa | Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor) | Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function. |
| P35568 | IRS1 | S862 | ochoa | Insulin receptor substrate 1 (IRS-1) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:19639489, ECO:0000269|PubMed:38625937, ECO:0000269|PubMed:7541045, ECO:0000269|PubMed:8265614}. |
| P35609 | ACTN2 | S624 | ochoa | Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. |
| P38935 | IGHMBP2 | S279 | ochoa | DNA-binding protein SMUBP-2 (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent helicase IGHMBP2) (Glial factor 1) (GF-1) (Immunoglobulin mu-binding protein 2) | 5' to 3' helicase that unwinds RNA and DNA duplexes in an ATP-dependent reaction (PubMed:19158098, PubMed:22999958, PubMed:30218034). Specific to 5'-phosphorylated single-stranded guanine-rich sequences (PubMed:22999958, PubMed:8349627). May play a role in RNA metabolism, ribosome biogenesis or initiation of translation (PubMed:19158098, PubMed:19299493). May play a role in regulation of transcription (By similarity). Interacts with tRNA-Tyr (PubMed:19299493). {ECO:0000250|UniProtKB:Q9EQN5, ECO:0000269|PubMed:19158098, ECO:0000269|PubMed:19299493, ECO:0000269|PubMed:22999958, ECO:0000269|PubMed:30218034, ECO:0000269|PubMed:8349627}. |
| P40222 | TXLNA | S495 | ochoa | Alpha-taxilin | May be involved in intracellular vesicle traffic and potentially in calcium-dependent exocytosis in neuroendocrine cells. |
| P41235 | HNF4A | S318 | psp | Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) (TCF-14) (Transcription factor HNF-4) | Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes (PubMed:30597922). Activates the transcription of CYP2C38 (By similarity). Represses the CLOCK-BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells (PubMed:30530698). {ECO:0000250|UniProtKB:P49698, ECO:0000269|PubMed:30530698, ECO:0000269|PubMed:30597922}. |
| P42575 | CASP2 | S139 | psp | Caspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] | Is a regulator of the cascade of caspases responsible for apoptosis execution (PubMed:11156409, PubMed:15073321, PubMed:8087842). Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival (PubMed:15073321). Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress (PubMed:15073321). {ECO:0000269|PubMed:11156409, ECO:0000269|PubMed:15073321, ECO:0000269|PubMed:8087842}.; FUNCTION: [Isoform 1]: Acts as a positive regulator of apoptosis. {ECO:0000269|PubMed:8087842}.; FUNCTION: [Isoform 2]: Acts as a negative regulator of apoptosis. {ECO:0000269|PubMed:8087842}.; FUNCTION: [Isoform 3]: May function as an endogenous apoptosis inhibitor that antagonizes caspase activation and cell death. {ECO:0000269|PubMed:11156409}. |
| P46939 | UTRN | S1866 | ochoa | Utrophin (Dystrophin-related protein 1) (DRP-1) | May play a role in anchoring the cytoskeleton to the plasma membrane. {ECO:0000250}. |
| P48681 | NES | S743 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P48681 | NES | S891 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P48729 | CSNK1A1 | S218 | psp | Casein kinase I isoform alpha (CKI-alpha) (EC 2.7.11.1) (CK1) | Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (PubMed:11955436, PubMed:1409656, PubMed:18305108, PubMed:23902688). It can phosphorylate a large number of proteins (PubMed:11955436, PubMed:1409656, PubMed:18305108, PubMed:23902688). Participates in Wnt signaling (PubMed:11955436). Phosphorylates CTNNB1 at 'Ser-45' (PubMed:11955436). May phosphorylate PER1 and PER2 (By similarity). May play a role in segregating chromosomes during mitosis (PubMed:1409656). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed:23902688). Acts as a positive regulator of mTORC1 and mTORC2 signaling in response to nutrients by mediating phosphorylation of DEPTOR inhibitor (PubMed:22017875, PubMed:22017877). Acts as an inhibitor of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity). {ECO:0000250|UniProtKB:Q8BK63, ECO:0000269|PubMed:11955436, ECO:0000269|PubMed:1409656, ECO:0000269|PubMed:18305108, ECO:0000269|PubMed:22017875, ECO:0000269|PubMed:22017877, ECO:0000269|PubMed:23902688}. |
| P49327 | FASN | S2156 | ochoa | Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] | Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269|PubMed:16215233, ECO:0000269|PubMed:16969344, ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
| P51955 | NEK2 | S365 | ochoa|psp | Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (HSPK 21) (Never in mitosis A-related kinase 2) (NimA-related protein kinase 2) (NimA-like protein kinase 1) | Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. Phosphorylates: PPP1CC; SGO1; NECAB3 and NPM1. Essential for localization of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome. Phosphorylates CEP68 and CNTLN directly or indirectly (PubMed:24554434). NEK2-mediated phosphorylation of CEP68 promotes CEP68 dissociation from the centrosome and its degradation at the onset of mitosis (PubMed:25704143). Involved in the regulation of centrosome disjunction (PubMed:26220856). Phosphorylates CCDC102B either directly or indirectly which causes CCDC102B to dissociate from the centrosome and allows for centrosome separation (PubMed:30404835). {ECO:0000269|PubMed:11742531, ECO:0000269|PubMed:12857871, ECO:0000269|PubMed:14978040, ECO:0000269|PubMed:15358203, ECO:0000269|PubMed:15388344, ECO:0000269|PubMed:17283141, ECO:0000269|PubMed:17621308, ECO:0000269|PubMed:17626005, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18297113, ECO:0000269|PubMed:20034488, ECO:0000269|PubMed:21076410, ECO:0000269|PubMed:24554434, ECO:0000269|PubMed:25704143, ECO:0000269|PubMed:26220856, ECO:0000269|PubMed:30404835}.; FUNCTION: [Isoform 1]: Phosphorylates and activates NEK11 in G1/S-arrested cells. {ECO:0000269|PubMed:15161910}.; FUNCTION: [Isoform 2]: Not present in the nucleolus and, in contrast to isoform 1, does not phosphorylate and activate NEK11 in G1/S-arrested cells. {ECO:0000269|PubMed:15161910}. |
| P52272 | HNRNPM | S575 | ochoa | Heterogeneous nuclear ribonucleoprotein M (hnRNP M) | Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines. |
| P52272 | HNRNPM | S588 | ochoa | Heterogeneous nuclear ribonucleoprotein M (hnRNP M) | Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines. |
| P54259 | ATN1 | S112 | ochoa | Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein) | Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats. {ECO:0000250|UniProtKB:O35126, ECO:0000269|PubMed:10085113, ECO:0000269|PubMed:10973986}. |
| P63098 | PPP3R1 | S37 | ochoa | Calcineurin subunit B type 1 (Protein phosphatase 2B regulatory subunit 1) (Protein phosphatase 3 regulatory subunit B alpha isoform 1) | Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity. {ECO:0000269|PubMed:26794871}. |
| P63098 | PPP3R1 | S45 | ochoa | Calcineurin subunit B type 1 (Protein phosphatase 2B regulatory subunit 1) (Protein phosphatase 3 regulatory subunit B alpha isoform 1) | Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity. {ECO:0000269|PubMed:26794871}. |
| P78371 | CCT2 | S60 | ochoa | T-complex protein 1 subunit beta (TCP-1-beta) (EC 3.6.1.-) (CCT-beta) (Chaperonin containing T-complex polypeptide 1 subunit 2) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P80303 | NUCB2 | S124 | ochoa | Nucleobindin-2 (DNA-binding protein NEFA) (Epididymis secretory protein Li 109) (Gastric cancer antigen Zg4) (Prepronesfatin) [Cleaved into: Nesfatin-1] | Calcium-binding protein which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein (G-protein) alpha subunit GNAI3 (By similarity). {ECO:0000250|UniProtKB:P81117, ECO:0000250|UniProtKB:Q9JI85}.; FUNCTION: [Nesfatin-1]: Anorexigenic peptide, seems to play an important role in hypothalamic pathways regulating food intake and energy homeostasis, acting in a leptin-independent manner. May also exert hypertensive roles and modulate blood pressure through directly acting on peripheral arterial resistance. In intestinal epithelial cells, plays a role in the inhibition of hepatic glucose production via MC4R receptor leading to increased cyclic adenosine monophosphate (cAMP) levels and glucagon-like peptide 1 (GLP-1) secretion (PubMed:39562740). {ECO:0000250|UniProtKB:Q9JI85, ECO:0000269|PubMed:39562740}. |
| Q01484 | ANK2 | S898 | ochoa | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}. |
| Q02952 | AKAP12 | S1507 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q06546 | GABPA | S62 | ochoa | GA-binding protein alpha chain (GABP subunit alpha) (Nuclear respiratory factor 2 subunit alpha) (Transcription factor E4TF1-60) | Transcription factor capable of interacting with purine rich repeats (GA repeats). Positively regulates transcription of transcriptional repressor RHIT/ZNF205 (PubMed:22306510). {ECO:0000269|PubMed:22306510}.; FUNCTION: (Microbial infection) Necessary for the expression of the Adenovirus E4 gene. |
| Q08357 | SLC20A2 | S259 | ochoa | Sodium-dependent phosphate transporter 2 (Gibbon ape leukemia virus receptor 2) (GLVR-2) (Phosphate transporter 2) (PiT-2) (Pit2) (hPit2) (Solute carrier family 20 member 2) | Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:12205090, PubMed:15955065, PubMed:16790504, PubMed:17494632, PubMed:22327515, PubMed:28722801, PubMed:30704756). Plays a critical role in the determination of bone quality and strength by providing phosphate for bone mineralization (By similarity). Required to maintain normal cerebrospinal fluid phosphate levels (By similarity). Mediates phosphate-induced calcification of vascular smooth muscle cells (VCMCs) and can functionally compensate for loss of SLC20A1 in VCMCs (By similarity). {ECO:0000250|UniProtKB:Q80UP8, ECO:0000269|PubMed:12205090, ECO:0000269|PubMed:15955065, ECO:0000269|PubMed:16790504, ECO:0000269|PubMed:17494632, ECO:0000269|PubMed:22327515, ECO:0000269|PubMed:28722801, ECO:0000269|PubMed:30704756}.; FUNCTION: (Microbial infection) Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) variants. {ECO:0000269|PubMed:11435563, ECO:0000269|PubMed:12205090, ECO:0000269|PubMed:15955065, ECO:0000269|PubMed:8302848}. |
| Q08378 | GOLGA3 | S1180 | ochoa | Golgin subfamily A member 3 (Golgi complex-associated protein of 170 kDa) (GCP170) (Golgin-160) | Golgi auto-antigen; probably involved in maintaining Golgi structure. |
| Q12802 | AKAP13 | S1857 | ochoa | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q12874 | SF3A3 | S292 | ochoa | Splicing factor 3A subunit 3 (SF3a60) (Spliceosome-associated protein 61) (SAP 61) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:10882114, PubMed:11533230, PubMed:32494006, PubMed:34822310, PubMed:8022796). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:10882114, PubMed:11533230, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3A3 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex (PubMed:10882114, PubMed:11533230). Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes (PubMed:29360106, PubMed:30315277). {ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:11533230, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:34822310, ECO:0000269|PubMed:8022796}. |
| Q12888 | TP53BP1 | S1618 | ochoa|psp | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12912 | IRAG2 | S378 | ochoa | Inositol 1,4,5-triphosphate receptor associated 2 (Lymphoid-restricted membrane protein) (Protein Jaw1) [Cleaved into: Processed inositol 1,4,5-triphosphate receptor associated 2] | Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion. Plays a role in maintaining nuclear shape, maybe as a component of the LINC complex and through interaction with microtubules. Plays a role in the regulation of cellular excitability by regulating the hyperpolarization-activated cyclic nucleotide-gated HCN4 channel activity (By similarity). {ECO:0000250|UniProtKB:Q60664}. |
| Q13043 | STK4 | S21 | ochoa|psp | Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)] | Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes. {ECO:0000250|UniProtKB:Q9JI11, ECO:0000269|PubMed:11278283, ECO:0000269|PubMed:11517310, ECO:0000269|PubMed:12757711, ECO:0000269|PubMed:15109305, ECO:0000269|PubMed:16510573, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:17932490, ECO:0000269|PubMed:18328708, ECO:0000269|PubMed:18986304, ECO:0000269|PubMed:19525978, ECO:0000269|PubMed:21212262, ECO:0000269|PubMed:21245099, ECO:0000269|PubMed:21512132, ECO:0000269|PubMed:8702870, ECO:0000269|PubMed:8816758}. |
| Q13263 | TRIM28 | S689 | ochoa | Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28) | Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also a corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:Q62318, ECO:0000269|PubMed:10347202, ECO:0000269|PubMed:11959841, ECO:0000269|PubMed:15882967, ECO:0000269|PubMed:16107876, ECO:0000269|PubMed:16862143, ECO:0000269|PubMed:17079232, ECO:0000269|PubMed:17178852, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17942393, ECO:0000269|PubMed:18060868, ECO:0000269|PubMed:18082607, ECO:0000269|PubMed:20424263, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:21940674, ECO:0000269|PubMed:23543754, ECO:0000269|PubMed:23665872, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:8769649, ECO:0000269|PubMed:9016654}.; FUNCTION: (Microbial infection) Plays a critical role in the shutdown of lytic gene expression during the early stage of herpes virus 8 primary infection. This inhibition is mediated through interaction with herpes virus 8 protein LANA1. {ECO:0000269|PubMed:24741090}. |
| Q13422 | IKZF1 | S361 | ochoa|psp | DNA-binding protein Ikaros (Ikaros family zinc finger protein 1) (Lymphoid transcription factor LyF-1) | Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067). {ECO:0000250|UniProtKB:Q03267, ECO:0000269|PubMed:10204490, ECO:0000269|PubMed:17135265, ECO:0000269|PubMed:17934067, ECO:0000269|PubMed:19141594}. |
| Q13439 | GOLGA4 | S213 | ochoa | Golgin subfamily A member 4 (256 kDa golgin) (Golgin-245) (Protein 72.1) (Trans-Golgi p230) | Involved in vesicular trafficking at the Golgi apparatus level. May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1. Involved in endosome-to-Golgi trafficking (PubMed:29084197). {ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:29084197}. |
| Q13444 | ADAM15 | S56 | ochoa | Disintegrin and metalloproteinase domain-containing protein 15 (ADAM 15) (EC 3.4.24.-) (Metalloprotease RGD disintegrin protein) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15) (MDC-15) (Metargidin) | Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain. {ECO:0000269|PubMed:12091380, ECO:0000269|PubMed:15358598, ECO:0000269|PubMed:15818704, ECO:0000269|PubMed:17416588, ECO:0000269|PubMed:17575078, ECO:0000269|PubMed:18387333, ECO:0000269|PubMed:18434311}. |
| Q13887 | KLF5 | S153 | psp | Krueppel-like factor 5 (Basic transcription element-binding protein 2) (BTE-binding protein 2) (Colon krueppel-like factor) (GC-box-binding protein 2) (Intestinal-enriched krueppel-like factor) (Transcription factor BTEB2) | Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes. |
| Q14126 | DSG2 | S680 | ochoa | Desmoglein-2 (Cadherin family member 5) (HDGC) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:38395410). Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Required for proliferation and viability of embryonic stem cells in the blastocyst, thereby crucial for progression of post-implantation embryonic development (By similarity). Maintains pluripotency by regulating epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via interacting with and sequestering CTNNB1 to sites of cell-cell contact, thereby reducing translocation of CTNNB1 to the nucleus and subsequent transcription of CTNNB1/TCF-target genes (PubMed:29910125). Promotes pluripotency and the multi-lineage differentiation potential of hematopoietic stem cells (PubMed:27338829). Plays a role in endothelial cell sprouting and elongation via mediating the junctional-association of cortical actin fibers and CDH5 (PubMed:27338829). Plays a role in limiting inflammatory infiltration and the apoptotic response to injury in kidney tubular epithelial cells, potentially via its role in maintaining cell-cell adhesion and the epithelial barrier (PubMed:38395410). {ECO:0000250|UniProtKB:O55111, ECO:0000269|PubMed:27338829, ECO:0000269|PubMed:29910125, ECO:0000269|PubMed:38395410}. |
| Q14155 | ARHGEF7 | S176 | ochoa | Rho guanine nucleotide exchange factor 7 (Beta-Pix) (COOL-1) (PAK-interacting exchange factor beta) (p85) | Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons. {ECO:0000250, ECO:0000269|PubMed:18184567, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750}. |
| Q14191 | WRN | S478 | ochoa | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (DNA helicase, RecQ-like type 3) (RecQ protein-like 2) (Werner syndrome protein) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)] | Multifunctional enzyme that has magnesium and ATP-dependent 3'-5' DNA-helicase activity on partially duplex substrates (PubMed:9224595, PubMed:9288107, PubMed:9611231). Also has 3'->5' exonuclease activity towards double-stranded (ds)DNA with a 5'-overhang (PubMed:11863428). Has no nuclease activity towards single-stranded (ss)DNA or blunt-ended dsDNA (PubMed:11863428). Helicase activity is most efficient with (d)ATP, but (d)CTP will substitute with reduced efficiency; strand displacement is enhanced by single-strand binding-protein (heterotrimeric replication protein A complex, RPA1, RPA2, RPA3) (PubMed:9611231). Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A (By similarity). Plays a role in double-strand break repair after gamma-irradiation (PubMed:9224595, PubMed:9288107, PubMed:9611231). Unwinds some G-quadruplex DNA (d(CGG)n tracts); unwinding seems to occur in both 5'-3' and 3'-5' direction and requires a short single-stranded tail (PubMed:10212265). d(CGG)n tracts have a propensity to assemble into tetraplex structures; other G-rich substrates from a telomeric or IgG switch sequence are not unwound (PubMed:10212265). Depletion leads to chromosomal breaks and genome instability (PubMed:33199508). {ECO:0000250|UniProtKB:O09053, ECO:0000269|PubMed:10212265, ECO:0000269|PubMed:11863428, ECO:0000269|PubMed:17563354, ECO:0000269|PubMed:18596042, ECO:0000269|PubMed:19283071, ECO:0000269|PubMed:19652551, ECO:0000269|PubMed:21639834, ECO:0000269|PubMed:27063109, ECO:0000269|PubMed:33199508, ECO:0000269|PubMed:9224595, ECO:0000269|PubMed:9288107, ECO:0000269|PubMed:9611231}. |
| Q14289 | PTK2B | S361 | ochoa | Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK) | Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376'. Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca(2+) levels. May also regulate potassium ion transport by phosphorylation of potassium channel subunits. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN; this requires both SRC and PTK2/PYK2. {ECO:0000269|PubMed:10022920, ECO:0000269|PubMed:12771146, ECO:0000269|PubMed:12893833, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:15050747, ECO:0000269|PubMed:15166227, ECO:0000269|PubMed:17634955, ECO:0000269|PubMed:18086875, ECO:0000269|PubMed:18339875, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:18765415, ECO:0000269|PubMed:19086031, ECO:0000269|PubMed:19207108, ECO:0000269|PubMed:19244237, ECO:0000269|PubMed:19428251, ECO:0000269|PubMed:19648005, ECO:0000269|PubMed:19880522, ECO:0000269|PubMed:20001213, ECO:0000269|PubMed:20381867, ECO:0000269|PubMed:20521079, ECO:0000269|PubMed:21357692, ECO:0000269|PubMed:21533080, ECO:0000269|PubMed:7544443, ECO:0000269|PubMed:8670418, ECO:0000269|PubMed:8849729}. |
| Q14644 | RASA3 | S282 | ochoa | Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) | Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) with high affinity. Might be a specific IP4 receptor. |
| Q14679 | TTLL4 | S912 | psp | Tubulin monoglutamylase TTLL4 (EC 6.3.2.-) (Protein monoglutamylase TTLL4) (Tubulin--tyrosine ligase-like protein 4) | Monoglutamylase which modifies both tubulin and non-tubulin proteins, adding a single glutamate on the gamma-carboxyl group of specific glutamate residues of target proteins. Involved in the side-chain initiation step of the polyglutamylation reaction but not in the elongation step. Preferentially modifies beta-tail tubulin over the alpha-tubulin. Monoglutamylates nucleosome assembly proteins NAP1L1 and NAP1L4. Monoglutamylates nucleotidyltransferase CGAS, leading to inhibition of CGAS catalytic activity, thereby preventing antiviral defense function. Involved in KLF4 glutamylation which impedes its ubiquitination, thereby leading to somatic cell reprogramming, pluripotency maintenance and embryogenesis. {ECO:0000250|UniProtKB:Q80UG8}. |
| Q14790 | CASP8 | S21 | ochoa | Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10] | Thiol protease that plays a key role in programmed cell death by acting as a molecular switch for apoptosis, necroptosis and pyroptosis, and is required to prevent tissue damage during embryonic development and adulthood (PubMed:23516580, PubMed:35338844, PubMed:35446120, PubMed:8681376, PubMed:8681377, PubMed:8962078, PubMed:9006941, PubMed:9184224). Initiator protease that induces extrinsic apoptosis by mediating cleavage and activation of effector caspases responsible for FAS/CD95-mediated and TNFRSF1A-induced cell death (PubMed:23516580, PubMed:35338844, PubMed:35446120, PubMed:8681376, PubMed:8681377, PubMed:8962078, PubMed:9006941, PubMed:9184224). Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10 (PubMed:16916640, PubMed:8962078, PubMed:9006941). Binding to the adapter molecule FADD recruits it to either receptor FAS/TNFRSF6 or TNFRSF1A (PubMed:8681376, PubMed:8681377). The resulting aggregate called the death-inducing signaling complex (DISC) performs CASP8 proteolytic activation (PubMed:9184224). The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases (PubMed:9184224). Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC (PubMed:9184224). In addition to extrinsic apoptosis, also acts as a negative regulator of necroptosis: acts by cleaving RIPK1 at 'Asp-324', which is crucial to inhibit RIPK1 kinase activity, limiting TNF-induced apoptosis, necroptosis and inflammatory response (PubMed:31827280, PubMed:31827281). Also able to initiate pyroptosis by mediating cleavage and activation of gasdermin-C and -D (GSDMC and GSDMD, respectively): gasdermin cleavage promotes release of the N-terminal moiety that binds to membranes and forms pores, triggering pyroptosis (PubMed:32929201, PubMed:34012073). Initiates pyroptosis following inactivation of MAP3K7/TAK1 (By similarity). Also acts as a regulator of innate immunity by mediating cleavage and inactivation of N4BP1 downstream of TLR3 or TLR4, thereby promoting cytokine production (By similarity). May participate in the Granzyme B (GZMB) cell death pathways (PubMed:8755496). Cleaves PARP1 and PARP2 (PubMed:8681376). Independent of its protease activity, promotes cell migration following phosphorylation at Tyr-380 (PubMed:18216014, PubMed:27109099). {ECO:0000250|UniProtKB:O89110, ECO:0000269|PubMed:16916640, ECO:0000269|PubMed:18216014, ECO:0000269|PubMed:23516580, ECO:0000269|PubMed:27109099, ECO:0000269|PubMed:31827280, ECO:0000269|PubMed:31827281, ECO:0000269|PubMed:32929201, ECO:0000269|PubMed:34012073, ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120, ECO:0000269|PubMed:8681376, ECO:0000269|PubMed:8681377, ECO:0000269|PubMed:8755496, ECO:0000269|PubMed:8962078, ECO:0000269|PubMed:9006941, ECO:0000269|PubMed:9184224}.; FUNCTION: [Isoform 5]: Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex. {ECO:0000305|PubMed:8681376}.; FUNCTION: [Isoform 6]: Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex. {ECO:0000305|PubMed:8681376}.; FUNCTION: [Isoform 7]: Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex (Probable). Acts as an inhibitor of the caspase cascade (PubMed:12010809). {ECO:0000269|PubMed:12010809, ECO:0000305|PubMed:8681376}.; FUNCTION: [Isoform 8]: Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex. {ECO:0000305|PubMed:8681376}. |
| Q14790 | CASP8 | S26 | ochoa | Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10] | Thiol protease that plays a key role in programmed cell death by acting as a molecular switch for apoptosis, necroptosis and pyroptosis, and is required to prevent tissue damage during embryonic development and adulthood (PubMed:23516580, PubMed:35338844, PubMed:35446120, PubMed:8681376, PubMed:8681377, PubMed:8962078, PubMed:9006941, PubMed:9184224). Initiator protease that induces extrinsic apoptosis by mediating cleavage and activation of effector caspases responsible for FAS/CD95-mediated and TNFRSF1A-induced cell death (PubMed:23516580, PubMed:35338844, PubMed:35446120, PubMed:8681376, PubMed:8681377, PubMed:8962078, PubMed:9006941, PubMed:9184224). Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10 (PubMed:16916640, PubMed:8962078, PubMed:9006941). Binding to the adapter molecule FADD recruits it to either receptor FAS/TNFRSF6 or TNFRSF1A (PubMed:8681376, PubMed:8681377). The resulting aggregate called the death-inducing signaling complex (DISC) performs CASP8 proteolytic activation (PubMed:9184224). The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases (PubMed:9184224). Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC (PubMed:9184224). In addition to extrinsic apoptosis, also acts as a negative regulator of necroptosis: acts by cleaving RIPK1 at 'Asp-324', which is crucial to inhibit RIPK1 kinase activity, limiting TNF-induced apoptosis, necroptosis and inflammatory response (PubMed:31827280, PubMed:31827281). Also able to initiate pyroptosis by mediating cleavage and activation of gasdermin-C and -D (GSDMC and GSDMD, respectively): gasdermin cleavage promotes release of the N-terminal moiety that binds to membranes and forms pores, triggering pyroptosis (PubMed:32929201, PubMed:34012073). Initiates pyroptosis following inactivation of MAP3K7/TAK1 (By similarity). Also acts as a regulator of innate immunity by mediating cleavage and inactivation of N4BP1 downstream of TLR3 or TLR4, thereby promoting cytokine production (By similarity). May participate in the Granzyme B (GZMB) cell death pathways (PubMed:8755496). Cleaves PARP1 and PARP2 (PubMed:8681376). Independent of its protease activity, promotes cell migration following phosphorylation at Tyr-380 (PubMed:18216014, PubMed:27109099). {ECO:0000250|UniProtKB:O89110, ECO:0000269|PubMed:16916640, ECO:0000269|PubMed:18216014, ECO:0000269|PubMed:23516580, ECO:0000269|PubMed:27109099, ECO:0000269|PubMed:31827280, ECO:0000269|PubMed:31827281, ECO:0000269|PubMed:32929201, ECO:0000269|PubMed:34012073, ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120, ECO:0000269|PubMed:8681376, ECO:0000269|PubMed:8681377, ECO:0000269|PubMed:8755496, ECO:0000269|PubMed:8962078, ECO:0000269|PubMed:9006941, ECO:0000269|PubMed:9184224}.; FUNCTION: [Isoform 5]: Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex. {ECO:0000305|PubMed:8681376}.; FUNCTION: [Isoform 6]: Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex. {ECO:0000305|PubMed:8681376}.; FUNCTION: [Isoform 7]: Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex (Probable). Acts as an inhibitor of the caspase cascade (PubMed:12010809). {ECO:0000269|PubMed:12010809, ECO:0000305|PubMed:8681376}.; FUNCTION: [Isoform 8]: Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex. {ECO:0000305|PubMed:8681376}. |
| Q14980 | NUMA1 | S1947 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q14994 | NR1I3 | S192 | psp | Nuclear receptor subfamily 1 group I member 3 (Constitutive activator of retinoid response) (Constitutive active response) (Constitutive androstane receptor) (CAR) (Orphan nuclear receptor MB67) | Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element. |
| Q15021 | NCAPD2 | S1310 | ochoa | Condensin complex subunit 1 (Chromosome condensation-related SMC-associated protein 1) (Chromosome-associated protein D2) (hCAP-D2) (Non-SMC condensin I complex subunit D2) (XCAP-D2 homolog) | Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain (PubMed:11136719). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:11136719, ECO:0000269|PubMed:27737959}. |
| Q15149 | PLEC | S224 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q15149 | PLEC | S3116 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q15208 | STK38 | S91 | psp | Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1) | Serine/threonine-protein kinase that acts as a negative regulator of MAP3K1/2 signaling (PubMed:12493777, PubMed:15197186, PubMed:17906693, PubMed:7761441). Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2 (PubMed:12493777, PubMed:15197186, PubMed:17906693, PubMed:7761441). Acts as an ufmylation 'reader' in a kinase-independent manner: specifically recognizes and binds mono-ufmylated histone H4 in response to DNA damage, promoting the recruitment of SUV39H1 to the double-strand breaks, resulting in ATM activation (PubMed:32537488). {ECO:0000269|PubMed:12493777, ECO:0000269|PubMed:15197186, ECO:0000269|PubMed:17906693, ECO:0000269|PubMed:32537488, ECO:0000269|PubMed:7761441}. |
| Q15398 | DLGAP5 | S415 | ochoa | Disks large-associated protein 5 (DAP-5) (Discs large homolog 7) (Disks large-associated protein DLG7) (Hepatoma up-regulated protein) (HURP) | Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. {ECO:0000269|PubMed:12527899, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15145941}. |
| Q15631 | TSN | S190 | ochoa | Translin (EC 3.1.-.-) (Component 3 of promoter of RISC) (C3PO) | DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots. {ECO:0000269|PubMed:9111049}.; FUNCTION: Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand. {ECO:0000269|PubMed:21552258}. |
| Q15772 | SPEG | S476 | ochoa | Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) | Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. |
| Q15942 | ZYX | S153 | ochoa | Zyxin (Zyxin-2) | Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity). {ECO:0000250}. |
| Q16621 | NFE2 | S157 | psp | Transcription factor NF-E2 45 kDa subunit (Leucine zipper protein NF-E2) (Nuclear factor, erythroid-derived 2 45 kDa subunit) (p45 NF-E2) | Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron. {ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:16287851}. |
| Q16647 | PTGIS | S221 | ochoa | Prostacyclin synthase (EC 5.3.99.4) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152) (Prostaglandin I2 synthase) | Catalyzes the biosynthesis and metabolism of eicosanoids. Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2), a potent mediator of vasodilation and inhibitor of platelet aggregation (PubMed:12372404, PubMed:15115769, PubMed:18032380, PubMed:25623425). Additionally, displays dehydratase activity, toward hydroperoxyeicosatetraenoates (HPETEs), especially toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) (PubMed:17459323). {ECO:0000269|PubMed:12372404, ECO:0000269|PubMed:15115769, ECO:0000269|PubMed:17459323, ECO:0000269|PubMed:18032380, ECO:0000269|PubMed:25623425}. |
| Q16706 | MAN2A1 | S939 | ochoa | Alpha-mannosidase 2 (EC 3.2.1.114) (Golgi alpha-mannosidase II) (AMan II) (Man II) (Mannosidase alpha class 2A member 1) (Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase) | Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway. {ECO:0000250|UniProtKB:P28494}. |
| Q16891 | IMMT | S403 | ochoa | MICOS complex subunit MIC60 (Cell proliferation-inducing gene 4/52 protein) (Mitochondrial inner membrane protein) (Mitofilin) (p87/89) | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). {ECO:0000269|PubMed:22114354, ECO:0000269|PubMed:25781180, ECO:0000269|PubMed:32567732, ECO:0000269|PubMed:33130824}. |
| Q18PE1 | DOK7 | S246 | ochoa | Protein Dok-7 (Downstream of tyrosine kinase 7) | Probable muscle-intrinsic activator of MUSK that plays an essential role in neuromuscular synaptogenesis. Acts in aneural activation of MUSK and subsequent acetylcholine receptor (AchR) clustering in myotubes. Induces autophosphorylation of MUSK. {ECO:0000269|PubMed:20603078}. |
| Q4KMG0 | CDON | S1076 | ochoa | Cell adhesion molecule-related/down-regulated by oncogenes | Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity). {ECO:0000250}. |
| Q5FWE3 | PRRT3 | S874 | ochoa | Proline-rich transmembrane protein 3 | None |
| Q5JTC6 | AMER1 | S318 | ochoa | APC membrane recruitment protein 1 (Amer1) (Protein FAM123B) (Wilms tumor gene on the X chromosome protein) | Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development. {ECO:0000269|PubMed:17510365, ECO:0000269|PubMed:17925383, ECO:0000269|PubMed:19416806, ECO:0000269|PubMed:21304492, ECO:0000269|PubMed:21498506}. |
| Q5QJE6 | DNTTIP2 | S330 | ochoa | Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) | Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}. |
| Q5SYE7 | NHSL1 | S1555 | ochoa | NHS-like protein 1 | None |
| Q5T5C0 | STXBP5 | S1058 | ochoa | Syntaxin-binding protein 5 (Lethal(2) giant larvae protein homolog 3) (Tomosyn-1) | Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane. Competes with STXBP1 for STX1 binding (By similarity). {ECO:0000250}. |
| Q5TDH0 | DDI2 | S150 | ochoa | Protein DDI1 homolog 2 (EC 3.4.23.-) | Aspartic protease that mediates the cleavage of NFE2L1/NRF1 at 'Leu-104', thereby promoting release of NFE2L1/NRF1 from the endoplasmic reticulum membrane (PubMed:27528193, PubMed:27676298). Ubiquitination of NFE2L1/NRF1 is a prerequisite for cleavage, suggesting that DDI2 specifically recognizes and binds ubiquitinated NFE2L1/NRF1 (PubMed:27528193). Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2 (Probable). Required, with DDI1, for cellular survival following replication stress. Together or redudantly with DDI1, removes RTF2 from stalled forks to allow cell cycle progression after replication stress and maintains genome integrity (PubMed:29290612). {ECO:0000269|PubMed:27528193, ECO:0000269|PubMed:27676298, ECO:0000269|PubMed:29290612, ECO:0000305|PubMed:29290612}. |
| Q5VST9 | OBSCN | S6963 | ochoa | Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) | Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). {ECO:0000250|UniProtKB:A2AAJ9, ECO:0000269|PubMed:11448995, ECO:0000269|PubMed:16205939, ECO:0000269|PubMed:28826662}. |
| Q5VT06 | CEP350 | S1265 | ochoa | Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) | Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CPAP (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}. |
| Q6KC79 | NIPBL | S588 | ochoa | Nipped-B-like protein (Delangin) (SCC2 homolog) | Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}. |
| Q6P2E9 | EDC4 | S672 | ochoa | Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls) | In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). {ECO:0000269|PubMed:16364915}. |
| Q6P2E9 | EDC4 | S1380 | ochoa | Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls) | In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). {ECO:0000269|PubMed:16364915}. |
| Q6P3W7 | SCYL2 | S292 | ochoa | SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa) | Component of the AP2-containing clathrin coat that may regulate clathrin-dependent trafficking at plasma membrane, TGN and endosomal system (Probable). A possible serine/threonine-protein kinase toward the beta2-subunit of the plasma membrane adapter complex AP2 and other proteins in presence of poly-L-lysine has not been confirmed (PubMed:15809293, PubMed:16914521). By regulating the expression of excitatory receptors at synapses, plays an essential role in neuronal function and signaling and in brain development (By similarity). {ECO:0000250|UniProtKB:Q8CFE4, ECO:0000269|PubMed:15809293, ECO:0000269|PubMed:16914521, ECO:0000305|PubMed:15809293, ECO:0000305|PubMed:16914521}. |
| Q6P5Z2 | PKN3 | S866 | ochoa | Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN-beta) (Protein-kinase C-related kinase 3) | Contributes to invasiveness in malignant prostate cancer. {ECO:0000269|PubMed:15282551}. |
| Q6UWE0 | LRSAM1 | S562 | ochoa | E3 ubiquitin-protein ligase LRSAM1 (EC 2.3.2.27) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (RING-type E3 ubiquitin transferase LRSAM1) (Tsg101-associated ligase) (hTAL) | E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos (PubMed:15256501). Bacterial recognition protein that defends the cytoplasm from invasive pathogens (PubMed:23245322). Localizes to several intracellular bacterial pathogens and generates the bacteria-associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation (xenophagy) (PubMed:23245322, PubMed:25484098). {ECO:0000269|PubMed:15256501, ECO:0000269|PubMed:23245322, ECO:0000269|PubMed:25484098}. |
| Q6XZF7 | DNMBP | S324 | ochoa | Dynamin-binding protein (Scaffold protein Tuba) | Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions through F-actin organization in epithelial cells (PubMed:17015620, PubMed:19767742). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (PubMed:20479467). Plays a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi (By similarity). {ECO:0000250|UniProtKB:E2RP94, ECO:0000250|UniProtKB:Q6TXD4, ECO:0000269|PubMed:17015620, ECO:0000269|PubMed:19767742, ECO:0000269|PubMed:20479467}. |
| Q6ZRV2 | FAM83H | S1009 | ochoa | Protein FAM83H | May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:18252228, ECO:0000269|PubMed:23902688}. |
| Q6ZV29 | PNPLA7 | S469 | ochoa | Patatin-like phospholipase domain-containing protein 7 (EC 3.1.1.-) (EC 3.1.1.5) | Lysophospholipase which preferentially deacylates unsaturated lysophosphatidylcholine (C18:1), generating glycerophosphocholine. Also can deacylate, to a lesser extent, lysophosphatidylethanolamine (C18:1), lysophosphatidyl-L-serine (C18:1) and lysophosphatidic acid (C16:0). {ECO:0000250|UniProtKB:A2AJ88}. |
| Q7L3B6 | CDC37L1 | S88 | ochoa | Hsp90 co-chaperone Cdc37-like 1 (Hsp90-associating relative of Cdc37) | Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90. {ECO:0000250}. |
| Q7Z333 | SETX | S2472 | ochoa | Probable helicase senataxin (EC 3.6.4.-) (Amyotrophic lateral sclerosis 4 protein) (SEN1 homolog) (Senataxin) | Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription (PubMed:19515850, PubMed:21700224). Contributes to the mRNA splicing efficiency and splice site selection (PubMed:19515850). Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (PubMed:19515850, PubMed:21700224, PubMed:26700805). Required for the 3' transcriptional termination of PER1 and CRY2, thus playing an important role in the circadian rhythm regulation (By similarity). Involved in DNA double-strand breaks damage response generated by oxidative stress (PubMed:17562789). In association with RRP45, targets the RNA exosome complex to sites of transcription-induced DNA damage (PubMed:24105744). Plays a role in the development and maturation of germ cells: essential for male meiosis, acting at the interface of transcription and meiotic recombination, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI) (By similarity). May be involved in telomeric stability through the regulation of telomere repeat-containing RNA (TERRA) transcription (PubMed:21112256). Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways. Inhibits retinoic acid-induced apoptosis (PubMed:21576111). {ECO:0000250|UniProtKB:A2AKX3, ECO:0000269|PubMed:17562789, ECO:0000269|PubMed:19515850, ECO:0000269|PubMed:21112256, ECO:0000269|PubMed:21576111, ECO:0000269|PubMed:21700224, ECO:0000269|PubMed:24105744, ECO:0000269|PubMed:26700805}. |
| Q7Z4G4 | TRMT11 | S441 | ochoa | tRNA (guanine(10)-N(2))-methyltransferase TRMT11 (EC 2.1.1.214) (tRNA methyltransferase 11 homolog) | Catalytic subunit of the TRMT11-TRM112 methyltransferase complex, that specifically mediates the S-adenosyl-L-methionine-dependent N(2)-methylation of guanosine nucleotide at position 10 (m2G10) in tRNAs (PubMed:37283053). This is one of the major tRNA (guanine-N(2))-methyltransferases (PubMed:37283053). {ECO:0000269|PubMed:37283053}. |
| Q86SQ0 | PHLDB2 | S277 | ochoa | Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) | Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}. |
| Q86VF7 | NRAP | S437 | ochoa | Nebulin-related-anchoring protein (N-RAP) | May be involved in anchoring the terminal actin filaments in the myofibril to the membrane and in transmitting tension from the myofibrils to the extracellular matrix. {ECO:0000250|UniProtKB:Q80XB4}. |
| Q86VY9 | TMEM200A | S397 | ochoa | Transmembrane protein 200A | None |
| Q8IV36 | HID1 | S648 | ochoa | Protein HID1 (Down-regulated in multiple cancers 1) (HID1 domain-containing protein) (Protein hid-1 homolog) | May play an important role in the development of cancers in a broad range of tissues. {ECO:0000269|PubMed:11281419}. |
| Q8IVF2 | AHNAK2 | S765 | ochoa | Protein AHNAK2 | None |
| Q8IVF7 | FMNL3 | S191 | ochoa | Formin-like protein 3 (Formin homology 2 domain-containing protein 3) (WW domain-binding protein 3) (WBP-3) | Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Required for developmental angiogenesis (By similarity). In this process, required for microtubule reorganization and for efficient endothelial cell elongation. In quiescent endothelial cells, triggers rearrangement of the actin cytoskeleton, but does not alter microtubule alignement. {ECO:0000250|UniProtKB:Q6NXC0, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22275430}. |
| Q8IWB9 | TEX2 | S220 | ochoa | Testis-expressed protein 2 (Transmembrane protein 96) | During endoplasmic reticulum (ER) stress or when cellular ceramide levels increase, may induce contacts between the ER and medial-Golgi complex to facilitate non-vesicular transport of ceramides from the ER to the Golgi complex where they are converted to complex sphingolipids, preventing toxic ceramide accumulation. {ECO:0000269|PubMed:28011845}. |
| Q8IWB9 | TEX2 | S538 | ochoa | Testis-expressed protein 2 (Transmembrane protein 96) | During endoplasmic reticulum (ER) stress or when cellular ceramide levels increase, may induce contacts between the ER and medial-Golgi complex to facilitate non-vesicular transport of ceramides from the ER to the Golgi complex where they are converted to complex sphingolipids, preventing toxic ceramide accumulation. {ECO:0000269|PubMed:28011845}. |
| Q8IXI1 | RHOT2 | S331 | ochoa | Mitochondrial Rho GTPase 2 (MIRO-2) (hMiro-2) (EC 3.6.5.-) (Ras homolog gene family member T2) | Atypical mitochondrial nucleoside-triphosphatase (NTPase) involved in mitochondrial trafficking (PubMed:16630562, PubMed:22396657, PubMed:30513825). Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (PubMed:22396657). Can hydrolyze GTP (By similarity). Can hydrolyze ATP and UTP (PubMed:30513825). {ECO:0000250|UniProtKB:Q8IXI2, ECO:0000269|PubMed:16630562, ECO:0000269|PubMed:22396657, ECO:0000269|PubMed:30513825}. |
| Q8N0X7 | SPART | S102 | ochoa | Spartin (Spastic paraplegia 20 protein) (Trans-activated by hepatitis C virus core protein 1) | Lipophagy receptor that plays an important role in lipid droplet (LD) turnover in motor neurons (PubMed:37443287). Localizes to LDs and interacts with components of the autophagy machinery, such as MAP1LC3A/C proteins to deliver LDs to autophagosomes for degradation via lipophagy (PubMed:37443287). Lipid transfer protein required for lipid droplet degradation, including by lipophagy (PubMed:38190532). Can bind and transfer all lipid species found in lipid droplets, from phospholipids to triglycerides and sterol esters but the direction of lipid transfer by spartin and its cargos are unknown (PubMed:38190532). May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis (PubMed:20719964). {ECO:0000269|PubMed:20719964, ECO:0000269|PubMed:37443287, ECO:0000269|PubMed:38190532}. |
| Q8N1G0 | ZNF687 | S1149 | ochoa | Zinc finger protein 687 | May be involved in transcriptional regulation. |
| Q8N205 | SYNE4 | S318 | ochoa | Nesprin-4 (KASH domain-containing protein 4) (KASH4) (Nuclear envelope spectrin repeat protein 4) | As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (By similarity). Behaves as a kinesin cargo, providing a functional binding site for kinesin-1 at the nuclear envelope. Hence may contribute to the establishment of secretory epithelial morphology by promoting kinesin-dependent apical migration of the centrosome and Golgi apparatus and basal localization of the nucleus (By similarity). {ECO:0000250}. |
| Q8N4S0 | CCDC82 | S329 | ochoa | Coiled-coil domain-containing protein 82 | None |
| Q8N4X5 | AFAP1L2 | S346 | ochoa | Actin filament-associated protein 1-like 2 (AFAP1-like protein 2) | May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation. {ECO:0000269|PubMed:17412687}. |
| Q8N5A5 | ZGPAT | S53 | ochoa | Zinc finger CCCH-type with G patch domain-containing protein (G patch domain-containing protein 6) (Zinc finger CCCH domain-containing protein 9) (Zinc finger and G patch domain-containing protein) | Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis. {ECO:0000269|PubMed:19644445}.; FUNCTION: [Isoform 4]: Antagonizes the transcription repression by isoform 1 by competing for the binding of the NuRD complex. Does not bind DNA. {ECO:0000269|PubMed:19644445}. |
| Q8N7J2 | AMER2 | S233 | ochoa | APC membrane recruitment protein 2 (Amer2) (Protein FAM123A) | Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. {ECO:0000269|PubMed:22128170}. |
| Q8N7Z5 | ANKRD31 | S43 | ochoa | Ankyrin repeat domain-containing protein 31 | Required for DNA double-strand breaks (DSBs) formation during meiotic recombination. Regulates the spatial and temporal patterns of pre-DSB recombinosome assembly and recombination activity by acting as a scaffold that anchors REC114 and other factors to specific genomic locations, thereby regulating DSB formation. Plays a key role in recombination in the pseudoautosomal regions of sex chromosomes. {ECO:0000250|UniProtKB:A0A140LI88}. |
| Q8N9N5 | BANP | S145 | ochoa | Protein BANP (BEN domain-containing protein 1) (Btg3-associated nuclear protein) (Scaffold/matrix-associated region-1-binding protein) | Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function (By similarity). Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer (By similarity). Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels (PubMed:16166625). Promotes TP53 activation, which causes cell cycle arrest (By similarity). Plays a role in the regulation of alternative splicing (PubMed:26080397). Binds to CD44 pre-mRNA and negatively regulates the inclusion of CD44 proximal variable exons v2-v6 but has no effect on distal variable exons v7-v10 (PubMed:26080397). {ECO:0000250|UniProtKB:Q8VBU8, ECO:0000269|PubMed:16166625, ECO:0000269|PubMed:26080397}. |
| Q8NDX1 | PSD4 | S24 | ochoa | PH and SEC7 domain-containing protein 4 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 B) (Exchange factor for ARF6 B) (Pleckstrin homology and SEC7 domain-containing protein 4) (Telomeric of interleukin-1 cluster protein) | Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate. {ECO:0000269|PubMed:12082148, ECO:0000269|PubMed:21458045}. |
| Q8NEF9 | SRFBP1 | S347 | ochoa | Serum response factor-binding protein 1 (SRF-dependent transcription regulation-associated protein) (p49/STRAP) | May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells (By similarity). {ECO:0000250|UniProtKB:Q9CZ91}. |
| Q8NFC6 | BOD1L1 | S1077 | ochoa | Biorientation of chromosomes in cell division protein 1-like 1 | Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}. |
| Q8NG31 | KNL1 | S584 | ochoa | Outer kinetochore KNL1 complex subunit KNL1 (ALL1-fused gene from chromosome 15q14 protein) (AF15q14) (Bub-linking kinetochore protein) (Blinkin) (Cancer susceptibility candidate gene 5 protein) (Cancer/testis antigen 29) (CT29) (Kinetochore scaffold 1) (Kinetochore-null protein 1) (Protein CASC5) (Protein D40/AF15q14) | Acts as a component of the outer kinetochore KNL1 complex that serves as a docking point for spindle assembly checkpoint components and mediates microtubule-kinetochore interactions (PubMed:15502821, PubMed:17981135, PubMed:18045986, PubMed:19893618, PubMed:21199919, PubMed:22000412, PubMed:22331848, PubMed:27881301, PubMed:30100357). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules (PubMed:18045986, PubMed:19893618, PubMed:27881301). The outer kinetochore is made up of the ten-subunit KMN network, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:38459127, PubMed:38459128). Required for kinetochore binding by a distinct subset of kMAPs (kinetochore-bound microtubule-associated proteins) and motors (PubMed:19893618). Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore (PubMed:18045986, PubMed:27881301). Can bind either to microtubules or to the protein phosphatase 1 (PP1) catalytic subunits PPP1CA and PPP1CC (via overlapping binding sites), it has higher affinity for PP1 (PubMed:30100357). Recruits MAD2L1 to the kinetochore and also directly links BUB1 and BUB1B to the kinetochore (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:22331848, PubMed:25308863). In addition to orienting mitotic chromosomes, it is also essential for alignment of homologous chromosomes during meiotic metaphase I (By similarity). In meiosis I, required to activate the spindle assembly checkpoint at unattached kinetochores to correct erroneous kinetochore-microtubule attachments (By similarity). {ECO:0000250|UniProtKB:Q66JQ7, ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:17981135, ECO:0000269|PubMed:18045986, ECO:0000269|PubMed:19893618, ECO:0000269|PubMed:21199919, ECO:0000269|PubMed:22000412, ECO:0000269|PubMed:22331848, ECO:0000269|PubMed:25308863, ECO:0000269|PubMed:27881301, ECO:0000269|PubMed:30100357, ECO:0000269|PubMed:38459127, ECO:0000269|PubMed:38459128}. |
| Q8NHM5 | KDM2B | S848 | ochoa | Lysine-specific demethylase 2B (EC 1.14.11.27) (CXXC-type zinc finger protein 2) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10) (F-box/LRR-repeat protein 10) (JmjC domain-containing histone demethylation protein 1B) (Jumonji domain-containing EMSY-interactor methyltransferase motif protein) (Protein JEMMA) (Protein-containing CXXC domain 2) ([Histone-H3]-lysine-36 demethylase 1B) | Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36' (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation (PubMed:16362057, PubMed:17994099). May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Probable). {ECO:0000269|PubMed:16362057, ECO:0000269|PubMed:17994099, ECO:0000269|PubMed:26237645, ECO:0000305}. |
| Q8TBF2 | PRXL2B | S110 | ochoa | Prostamide/prostaglandin F synthase (Prostamide/PG F synthase) (Prostamide/PGF synthase) (EC 1.11.1.20) (Peroxiredoxin-like 2B) (Protein FAM213B) | Catalyzes the reduction of prostaglandin-ethanolamide H(2) (prostamide H(2)) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostaglandin H(2) to prostaglandin F(2alpha) (By similarity). {ECO:0000250|UniProtKB:Q9DB60}. |
| Q8TC07 | TBC1D15 | S201 | ochoa | TBC1 domain family member 15 (GTPase-activating protein RAB7) (GAP for RAB7) (Rab7-GAP) | Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6 (By similarity). {ECO:0000250}. |
| Q8TDY2 | RB1CC1 | S982 | ochoa | RB1-inducible coiled-coil protein 1 (FAK family kinase-interacting protein of 200 kDa) (FIP200) | Involved in autophagy (PubMed:21775823). Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225). Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (By similarity). Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (By similarity). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (PubMed:10769033, PubMed:12221124). Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (By similarity). Functions as a DNA-binding transcription factor (PubMed:12095676). Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:14533007). Plays a crucial role in muscular differentiation (PubMed:12163359). Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity). {ECO:0000250|UniProtKB:Q9ESK9, ECO:0000269|PubMed:10769033, ECO:0000269|PubMed:12095676, ECO:0000269|PubMed:12163359, ECO:0000269|PubMed:12221124, ECO:0000269|PubMed:14533007, ECO:0000269|PubMed:21775823, ECO:0000269|PubMed:23392225}. |
| Q8TED9 | AFAP1L1 | S349 | ochoa | Actin filament-associated protein 1-like 1 (AFAP1-like protein 1) | May be involved in podosome and invadosome formation. {ECO:0000269|PubMed:21333378}. |
| Q8TF72 | SHROOM3 | S419 | ochoa | Protein Shroom3 (Shroom-related protein) (hShrmL) | Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}. |
| Q8WUM0 | NUP133 | S1133 | ochoa | Nuclear pore complex protein Nup133 (133 kDa nucleoporin) (Nucleoporin Nup133) | Involved in poly(A)+ RNA transport. Involved in nephrogenesis (PubMed:30179222). {ECO:0000269|PubMed:11684705, ECO:0000269|PubMed:30179222}. |
| Q8WVB6 | CHTF18 | S225 | ochoa | Chromosome transmission fidelity protein 18 homolog (hCTF18) (CHL12) | Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. Interacts with and stimulates DNA polymerase POLH. During DNA repair synthesis, involved in loading DNA polymerase POLE at the sites of local damage (PubMed:20227374). {ECO:0000269|PubMed:12766176, ECO:0000269|PubMed:12930902, ECO:0000269|PubMed:17545166, ECO:0000269|PubMed:20227374}. |
| Q8WWQ0 | PHIP | S107 | ochoa | PH-interacting protein (PHIP) (DDB1- and CUL4-associated factor 14) (IRS-1 PH domain-binding protein) (WD repeat-containing protein 11) | Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:12242307, ECO:0000269|PubMed:21834987}. |
| Q8WYP5 | AHCTF1 | S1464 | ochoa | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}. |
| Q92887 | ABCC2 | S938 | ochoa | ATP-binding cassette sub-family C member 2 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (Canalicular multidrug resistance protein) (Canalicular multispecific organic anion transporter 1) (Multidrug resistance-associated protein 2) | ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports a wide variety of conjugated organic anions such as sulfate-, glucuronide- and glutathione (GSH)-conjugates of endo- and xenobiotics substrates (PubMed:10220572, PubMed:10421658, PubMed:11500505, PubMed:16332456). Mediates hepatobiliary excretion of mono- and bis-glucuronidated bilirubin molecules and therefore play an important role in bilirubin detoxification (PubMed:10421658). Also mediates hepatobiliary excretion of others glucuronide conjugates such as 17beta-estradiol 17-glucosiduronic acid and leukotriene C4 (PubMed:11500505). Transports sulfated bile salt such as taurolithocholate sulfate (PubMed:16332456). Transports various anticancer drugs, such as anthracycline, vinca alkaloid and methotrexate and HIV-drugs such as protease inhibitors (PubMed:10220572, PubMed:11500505, PubMed:12441801). Confers resistance to several anti-cancer drugs including cisplatin, doxorubicin, epirubicin, methotrexate, etoposide and vincristine (PubMed:10220572, PubMed:11500505). {ECO:0000269|PubMed:10220572, ECO:0000269|PubMed:10421658, ECO:0000269|PubMed:11500505, ECO:0000269|PubMed:12441801, ECO:0000269|PubMed:16332456}. |
| Q92911 | SLC5A5 | S43 | psp | Sodium/iodide cotransporter (Na(+)/I(-) cotransporter) (Natrium iodide transporter) (Sodium-iodide symporter) (Na(+)/I(-) symporter) (Solute carrier family 5 member 5) | Sodium:iodide symporter that mediates the transport of iodide into the thyroid gland (PubMed:12488351, PubMed:18372236, PubMed:18708479, PubMed:20797386, PubMed:31310151, PubMed:32084174, PubMed:8806637, PubMed:9329364). Can also mediate the transport of chlorate, thiocynate, nitrate and selenocynate (PubMed:12488351). {ECO:0000269|PubMed:12488351, ECO:0000269|PubMed:18372236, ECO:0000269|PubMed:18708479, ECO:0000269|PubMed:20797386, ECO:0000269|PubMed:31310151, ECO:0000269|PubMed:32084174, ECO:0000269|PubMed:8806637, ECO:0000269|PubMed:9329364}. |
| Q969K3 | RNF34 | S323 | ochoa | E3 ubiquitin-protein ligase RNF34 (EC 2.3.2.27) (Caspase regulator CARP1) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (RING finger protein 34) (RING finger protein RIFF) (RING-type E3 ubiquitin transferase RNF34) | E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis (PubMed:15069192). May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway (Ref.13). Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation (PubMed:17121812). Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN (PubMed:18382127). Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells (PubMed:22064484). Possibly involved in innate immunity, through 'Lys-48'-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation (PubMed:25012219). {ECO:0000269|PubMed:12118383, ECO:0000269|PubMed:15069192, ECO:0000269|PubMed:15897238, ECO:0000269|PubMed:17121812, ECO:0000269|PubMed:22064484, ECO:0000269|PubMed:25012219, ECO:0000269|Ref.13, ECO:0000303|PubMed:18382127}. |
| Q96BX8 | MOB3A | S38 | psp | MOB kinase activator 3A (MOB-LAK) (Mob1 homolog 2A) (Mps one binder kinase activator-like 2A) | May regulate the activity of kinases. {ECO:0000250}. |
| Q96CF2 | CHMP4C | S192 | ochoa | Charged multivesicular body protein 4c (Chromatin-modifying protein 4c) (CHMP4c) (SNF7 homolog associated with Alix 3) (SNF7-3) (hSnf7-3) (Vacuolar protein sorting-associated protein 32-3) (Vps32-3) (hVps32-3) | Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: upon phosphorylation by AURKB, together with ZFYVE19/ANCHR, retains abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ANCHR and VPS4 and subsequent abscission (PubMed:22422861, PubMed:24814515). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). {ECO:0000269|PubMed:14505569, ECO:0000269|PubMed:14505570, ECO:0000269|PubMed:14519844, ECO:0000269|PubMed:22422861, ECO:0000269|PubMed:22660413, ECO:0000269|PubMed:24814515}. |
| Q96HH4 | TMEM169 | S20 | ochoa | Transmembrane protein 169 | None |
| Q96K17 | BTF3L4 | S109 | ochoa | Transcription factor BTF3 homolog 4 (Basic transcription factor 3-like 4) | None |
| Q96KQ4 | PPP1R13B | S486 | ochoa | Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B) | Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53 (PubMed:11684014, PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. {ECO:0000269|PubMed:11684014, ECO:0000269|PubMed:12524540}. |
| Q96KR1 | ZFR | S476 | ochoa | Zinc finger RNA-binding protein (hZFR) (M-phase phosphoprotein homolog) | Involved in postimplantation and gastrulation stages of development. Involved in the nucleocytoplasmic shuttling of STAU2. Binds to DNA and RNA (By similarity). {ECO:0000250}. |
| Q96KS0 | EGLN2 | S226 | psp | Prolyl hydroxylase EGLN2 (EC 1.14.11.-) (Egl nine homolog 2) (EC 1.14.11.29) (Estrogen-induced tag 6) (EIT-6) (HPH-3) (Hypoxia-inducible factor prolyl hydroxylase 1) (HIF-PH1) (HIF-prolyl hydroxylase 1) (HPH-1) (Prolyl hydroxylase domain-containing protein 1) (PHD1) | Prolyl hydroxylase that mediates hydroxylation of proline residues in target proteins, such as ATF4, IKBKB, CEP192 and HIF1A (PubMed:11595184, PubMed:12039559, PubMed:15925519, PubMed:16509823, PubMed:17114296, PubMed:23932902). Target proteins are preferentially recognized via a LXXLAP motif (PubMed:11595184, PubMed:12039559, PubMed:15925519). Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins (PubMed:11595184, PubMed:12039559, PubMed:12181324, PubMed:15925519, PubMed:19339211). Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A (PubMed:11595184, PubMed:12039559, PubMed:12181324, PubMed:15925519). Also hydroxylates HIF2A (PubMed:11595184, PubMed:12039559, PubMed:15925519). Has a preference for the CODD site for both HIF1A and HIF2A (PubMed:11595184, PubMed:12039559, PubMed:15925519). Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex (PubMed:11595184, PubMed:12039559, PubMed:15925519). Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes (PubMed:11595184, PubMed:12039559, PubMed:15925519). EGLN2 is involved in regulating hypoxia tolerance and apoptosis in cardiac and skeletal muscle (PubMed:11595184, PubMed:12039559, PubMed:15925519). Also regulates susceptibility to normoxic oxidative neuronal death (PubMed:11595184, PubMed:12039559, PubMed:15925519). Links oxygen sensing to cell cycle and primary cilia formation by hydroxylating the critical centrosome component CEP192 which promotes its ubiquitination and subsequent proteasomal degradation (PubMed:23932902). Hydroxylates IKBKB, mediating NF-kappa-B activation in hypoxic conditions (PubMed:17114296). Also mediates hydroxylation of ATF4, leading to decreased protein stability of ATF4 (By similarity). {ECO:0000250|UniProtKB:Q91YE2, ECO:0000269|PubMed:11595184, ECO:0000269|PubMed:12039559, ECO:0000269|PubMed:12181324, ECO:0000269|PubMed:15925519, ECO:0000269|PubMed:16509823, ECO:0000269|PubMed:17114296, ECO:0000269|PubMed:19339211, ECO:0000269|PubMed:23932902}. |
| Q96SN8 | CDK5RAP2 | S1244 | ochoa | CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215) | Potential regulator of CDK5 activity via its interaction with CDK5R1 (PubMed:15164053). Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter (PubMed:19282672). Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends (PubMed:18042621, PubMed:17959831, PubMed:19553473). Regulates centrosomal maturation by recruitment of the gamma-tubulin ring complex (gTuRC) onto centrosomes (PubMed:18042621, PubMed:17959831, PubMed:26485573, PubMed:39321809). In complex with PDE4DIP isoform 13/MMG8/SMYLE, MAPRE1 and AKAP9, contributes to microtubules nucleation and extension from the centrosome to the cell periphery (PubMed:29162697). Required for the recruitment of AKAP9 to centrosomes (PubMed:29162697). Plays a role in neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q8K389, ECO:0000269|PubMed:15164053, ECO:0000269|PubMed:17959831, ECO:0000269|PubMed:18042621, ECO:0000269|PubMed:19282672, ECO:0000269|PubMed:19553473, ECO:0000269|PubMed:26485573, ECO:0000269|PubMed:29162697, ECO:0000269|PubMed:39321809}. |
| Q99569 | PKP4 | S132 | ochoa | Plakophilin-4 (p0071) | Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269|PubMed:17115030}. |
| Q99590 | SCAF11 | S680 | ochoa | Protein SCAF11 (CTD-associated SR protein 11) (Renal carcinoma antigen NY-REN-40) (SC35-interacting protein 1) (SR-related and CTD-associated factor 11) (SRSF2-interacting protein) (Serine/arginine-rich splicing factor 2-interacting protein) (Splicing factor, arginine/serine-rich 2-interacting protein) (Splicing regulatory protein 129) (SRrp129) | Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly. {ECO:0000269|PubMed:9447963}. |
| Q9BPZ3 | PAIP2 | S101 | ochoa | Polyadenylate-binding protein-interacting protein 2 (PABP-interacting protein 2) (PAIP-2) (Poly(A)-binding protein-interacting protein 2) | Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization. {ECO:0000269|PubMed:11172725}. |
| Q9BQL6 | FERMT1 | S361 | ochoa | Fermitin family homolog 1 (Kindlerin) (Kindlin syndrome protein) (Kindlin-1) (Unc-112-related protein 1) | Involved in cell adhesion. Contributes to integrin activation. When coexpressed with talin, potentiates activation of ITGA2B. Required for normal keratinocyte proliferation. Required for normal polarization of basal keratinocytes in skin, and for normal cell shape. Required for normal adhesion of keratinocytes to fibronectin and laminin, and for normal keratinocyte migration to wound sites. May mediate TGF-beta 1 signaling in tumor progression. {ECO:0000269|PubMed:14634021, ECO:0000269|PubMed:17012746, ECO:0000269|PubMed:19804783}. |
| Q9BRD0 | BUD13 | S281 | ochoa | BUD13 homolog | Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000305|PubMed:33509932}. |
| Q9BRK0 | REEP2 | S193 | ochoa | Receptor expression-enhancing protein 2 | Required for endoplasmic reticulum (ER) network formation, shaping and remodeling. May enhance the cell surface expression of odorant receptors (By similarity). {ECO:0000250, ECO:0000269|PubMed:24388663}. |
| Q9BSJ2 | TUBGCP2 | S320 | ochoa | Gamma-tubulin complex component 2 (GCP-2) (hGCP2) (Gamma-ring complex protein 103 kDa) (h103p) (hGrip103) (Spindle pole body protein Spc97 homolog) (hSpc97) | Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:38305685, PubMed:38609661, PubMed:39321809, PubMed:9566967). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685, PubMed:38609661, PubMed:39321809). Plays a role in neuronal migration (PubMed:31630790). {ECO:0000269|PubMed:31630790, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809, ECO:0000269|PubMed:9566967}. |
| Q9BST9 | RTKN | S220 | ochoa | Rhotekin | Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. May play a novel role in the organization of septin structures. {ECO:0000269|PubMed:10940294, ECO:0000269|PubMed:15480428, ECO:0000269|PubMed:16007136}. |
| Q9BWT3 | PAPOLG | S508 | ochoa | Poly(A) polymerase gamma (PAP-gamma) (EC 2.7.7.19) (Neo-poly(A) polymerase) (Neo-PAP) (Polynucleotide adenylyltransferase gamma) (SRP RNA 3'-adenylating enzyme) (Signal recognition particle RNA-adenylating enzyme) (SRP RNA-adenylating enzyme) | Responsible for the post-transcriptional adenylation of the 3'-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA. {ECO:0000269|PubMed:11287430, ECO:0000269|PubMed:11463842}. |
| Q9BXK5 | BCL2L13 | S353 | ochoa | Bcl-2-like protein 13 (Bcl2-L-13) (Bcl-rambo) (Protein Mil1) | May promote the activation of caspase-3 and apoptosis. |
| Q9BYI3 | HYCC1 | S433 | ochoa | Hyccin (Down-regulated by CTNNB1 protein A) | Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (PubMed:26571211). HYCC1 plays a key role in oligodendrocytes formation, a cell type with expanded plasma membrane that requires generation of PtdIns(4)P (PubMed:26571211). Its role in oligodendrocytes formation probably explains its importance in myelination of the central and peripheral nervous system (PubMed:16951682, PubMed:26571211). May also have a role in the beta-catenin/Lef signaling pathway (Probable). {ECO:0000269|PubMed:16951682, ECO:0000269|PubMed:26571211, ECO:0000305|PubMed:10910037}. |
| Q9C0H5 | ARHGAP39 | S202 | ochoa | Rho GTPase-activating protein 39 | None |
| Q9H2Y7 | ZNF106 | S673 | ochoa | Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) | RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism. {ECO:0000250|UniProtKB:O88466}. |
| Q9H2Y7 | ZNF106 | S753 | ochoa | Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) | RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism. {ECO:0000250|UniProtKB:O88466}. |
| Q9H6A0 | DENND2D | S357 | ochoa | DENN domain-containing protein 2D | Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}. |
| Q9HCE7 | SMURF1 | S363 | ochoa | E3 ubiquitin-protein ligase SMURF1 (hSMURF1) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF1) (SMAD ubiquitination regulatory factor 1) (SMAD-specific E3 ubiquitin-protein ligase 1) | E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Promotes ubiquitination and subsequent proteasomal degradation of MAVS (PubMed:23087404). Acts as an antagonist of TGF-beta signaling by ubiquitinating TGFBR1 and targeting it for degradation (PubMed:21791611). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000269|PubMed:10458166, ECO:0000269|PubMed:19937093, ECO:0000269|PubMed:21402695, ECO:0000269|PubMed:21791611, ECO:0000269|PubMed:23087404, ECO:0000269|PubMed:23999003}. |
| Q9NQ75 | CASS4 | S165 | ochoa | Cas scaffolding protein family member 4 (HEF-like protein) (HEF1-EFS-p130Cas-like protein) (HEPL) | Docking protein that plays a role in tyrosine kinase-based signaling related to cell adhesion and cell spreading. Regulates PTK2/FAK1 activity, focal adhesion integrity, and cell spreading. {ECO:0000269|PubMed:18256281}. |
| Q9NQ89 | FERRY3 | S241 | ochoa | Ferry endosomal RAB5 effector complex subunit 3 (Fy-3) | Component of the FERRY complex (Five-subunit Endosomal Rab5 and RNA/ribosome intermediary) (PubMed:37267905). The FERRY complex directly interacts with mRNAs and RAB5A, and functions as a RAB5A effector involved in the localization and the distribution of specific mRNAs most likely by mediating their endosomal transport. The complex recruits mRNAs and ribosomes to early endosomes through direct mRNA-interaction (PubMed:37267905). Plays a role in mast cell degranulation. {ECO:0000250|UniProtKB:D4A770, ECO:0000269|PubMed:37267905}. |
| Q9NQS7 | INCENP | S235 | ochoa | Inner centromere protein | Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:12925766, PubMed:15316025, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428). {ECO:0000250|UniProtKB:P53352, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:21346195, ECO:0000269|PubMed:27332895}. |
| Q9NQW6 | ANLN | S141 | ochoa | Anillin | Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}. |
| Q9NSI6 | BRWD1 | S1611 | ochoa | Bromodomain and WD repeat-containing protein 1 (WD repeat-containing protein 9) | May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000250, ECO:0000269|PubMed:21834987}. |
| Q9NV70 | EXOC1 | S297 | ochoa | Exocyst complex component 1 (Exocyst complex component Sec3) | Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.; FUNCTION: (Microbial infection) Has an antiviral effect against flaviviruses by affecting viral RNA transcription and translation through the sequestration of elongation factor 1-alpha (EEF1A1). This results in decreased viral RNA synthesis and decreased viral protein translation. {ECO:0000269|PubMed:19889084}. |
| Q9NYB0 | TERF2IP | S179 | ochoa | Telomeric repeat-binding factor 2-interacting protein 1 (TERF2-interacting telomeric protein 1) (TRF2-interacting telomeric protein 1) (Dopamine receptor-interacting protein 5) (Repressor/activator protein 1 homolog) (RAP1 homolog) (hRap1) | Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes. {ECO:0000269|PubMed:16166375, ECO:0000269|PubMed:19763083}. |
| Q9P209 | CEP72 | S156 | ochoa | Centrosomal protein of 72 kDa (Cep72) | Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required for localization of KIZ, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs) (PubMed:19536135). Involved in centriole duplication. Required for CDK5RAP22, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). {ECO:0000269|PubMed:19536135, ECO:0000269|PubMed:26297806}. |
| Q9P2J5 | LARS1 | S66 | ochoa | Leucine--tRNA ligase, cytoplasmic (EC 6.1.1.4) (Leucyl-tRNA synthetase) (LeuRS) (cLRS) | Aminoacyl-tRNA synthetase that catalyzes the specific attachment of leucine to its cognate tRNA (tRNA(Leu)) (PubMed:25051973, PubMed:32232361). It performs tRNA aminoacylation in a two-step reaction: Leu is initially activated by ATP to form a leucyl-adenylate (Leu-AMP) intermediate; then the leucyl moiety is transferred to the acceptor 3' end of the tRNA to yield leucyl-tRNA (PubMed:25051973). To improve the fidelity of catalytic reactions, it is also able to hydrolyze misactivated aminoacyl-adenylate intermediates (pre-transfer editing) and mischarged aminoacyl-tRNAs (post-transfer editing) (PubMed:25051973). {ECO:0000269|PubMed:19426743, ECO:0000269|PubMed:25051973, ECO:0000269|PubMed:32232361}. |
| Q9UBC2 | EPS15L1 | S575 | ochoa | Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) | Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:9407958}. |
| Q9UIF9 | BAZ2A | S1163 | ochoa | Bromodomain adjacent to zinc finger domain protein 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3) | Regulatory subunit of the ATP-dependent NoRC-1 and NoRC-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Directly stimulates the ATPase activity of SMARCA5 in the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). The NoRC-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NoRC-5 ISWI chromatin remodeling complex, mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription (By similarity). Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac (By similarity). Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity). {ECO:0000250|UniProtKB:Q91YE5, ECO:0000269|PubMed:28801535}. |
| Q9UK61 | TASOR | S1219 | ochoa | Protein TASOR (CTCL tumor antigen se89-1) (Retinoblastoma-associated protein RAP140) (Transgene activation suppressor protein) | Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression (PubMed:26022416, PubMed:28581500). The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Plays a crucial role in early embryonic development (By similarity). Involved in the organization of spindle poles and spindle apparatus assembly during zygotic division (By similarity). Plays an important role in maintaining epiblast fitness or potency (By similarity). {ECO:0000250|UniProtKB:Q69ZR9, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}. |
| Q9UKJ3 | GPATCH8 | S62 | ochoa | G patch domain-containing protein 8 | None |
| Q9UKK3 | PARP4 | S1507 | ochoa | Protein mono-ADP-ribosyltransferase PARP4 (EC 2.4.2.-) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Poly [ADP-ribose] polymerase 4) (PARP-4) (Vault poly(ADP-ribose) polymerase) (VPARP) | Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. {ECO:0000269|PubMed:25043379}. |
| Q9ULC8 | ZDHHC8 | S571 | ochoa | Palmitoyltransferase ZDHHC8 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 8) (DHHC-8) (Zinc finger protein 378) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (Probable). Through the palmitoylation of ABCA1 regulates the localization of the transporter to the plasma membrane and thereby regulates its function in cholesterol and phospholipid efflux (Probable). Could also pamitoylate the D(2) dopamine receptor DRD2 and regulate its stability and localization to the plasma membrane (Probable). Could also play a role in glutamatergic transmission (By similarity). {ECO:0000250|UniProtKB:Q5Y5T5, ECO:0000305|PubMed:19556522, ECO:0000305|PubMed:23034182, ECO:0000305|PubMed:26535572}.; FUNCTION: (Microbial infection) Able to palmitoylate SARS coronavirus-2/SARS-CoV-2 spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment. Once the virus has formed, spike palmitoylation controls fusion with the target cell. {ECO:0000269|PubMed:34599882}. |
| Q9ULH1 | ASAP1 | S910 | ochoa | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP) | Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:25673879). {ECO:0000250, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:25673879}. |
| Q9ULH7 | MRTFB | S913 | ochoa | Myocardin-related transcription factor B (MRTF-B) (MKL/myocardin-like protein 2) (Megakaryoblastic leukemia 2) | Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation. {ECO:0000269|PubMed:14565952}. |
| Q9ULI0 | ATAD2B | S1379 | ochoa | ATPase family AAA domain-containing protein 2B | None |
| Q9ULJ3 | ZBTB21 | S233 | ochoa | Zinc finger and BTB domain-containing protein 21 (Zinc finger protein 295) | Acts as a transcription repressor. {ECO:0000269|PubMed:15629158}. |
| Q9UQB3 | CTNND2 | S398 | ochoa | Catenin delta-2 (Delta-catenin) (GT24) (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin) | Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses (PubMed:25807484). Involved in the regulation of Wnt signaling (PubMed:25807484). It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation (By similarity). Functions as a transcriptional activator when bound to ZBTB33 (By similarity). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. {ECO:0000250|UniProtKB:O35927, ECO:0000269|PubMed:25807484, ECO:0000269|PubMed:9971746}. |
| Q9Y314 | NOSIP | S166 | ochoa | Nitric oxide synthase-interacting protein (E3 ubiquitin-protein ligase NOSIP) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase NOSIP) (eNOS-interacting protein) | E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (By similarity). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity (PubMed:11149895, PubMed:15548660, PubMed:16135813). {ECO:0000250|UniProtKB:Q9D6T0, ECO:0000269|PubMed:11149895, ECO:0000269|PubMed:15548660, ECO:0000269|PubMed:16135813}. |
| Q9Y3Z3 | SAMHD1 | S283 | ochoa | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) (EC 3.1.5.-) (Dendritic cell-derived IFNG-induced protein) (DCIP) (Monocyte protein 5) (MOP-5) (SAM domain and HD domain-containing protein 1) (hSAMHD1) | Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks (PubMed:19525956, PubMed:21613998, PubMed:21720370, PubMed:22056990, PubMed:23601106, PubMed:23602554, PubMed:24336198, PubMed:26294762, PubMed:26431200, PubMed:28229507, PubMed:28834754, PubMed:29670289). Has deoxynucleoside triphosphate (dNTPase) activity, which is required to restrict infection by viruses, such as HIV-1: dNTPase activity reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur, blocking early-stage virus replication in dendritic and other myeloid cells (PubMed:19525956, PubMed:21613998, PubMed:21720370, PubMed:22056990, PubMed:23364794, PubMed:23601106, PubMed:23602554, PubMed:24336198, PubMed:25038827, PubMed:26101257, PubMed:26294762, PubMed:26431200, PubMed:28229507). Likewise, suppresses LINE-1 retrotransposon activity (PubMed:24035396, PubMed:24217394, PubMed:29610582). Not able to restrict infection by HIV-2 virus; because restriction activity is counteracted by HIV-2 viral protein Vpx (PubMed:21613998, PubMed:21720370). In addition to virus restriction, dNTPase activity acts as a regulator of DNA precursor pools by regulating dNTP pools (PubMed:23858451). Phosphorylation at Thr-592 acts as a switch to control dNTPase-dependent and -independent functions: it inhibits dNTPase activity and ability to restrict infection by viruses, while it promotes DNA end resection at stalled replication forks (PubMed:23601106, PubMed:23602554, PubMed:29610582, PubMed:29670289). Functions during S phase at stalled DNA replication forks to promote the resection of gapped or reversed forks: acts by stimulating the exonuclease activity of MRE11, activating the ATR-CHK1 pathway and allowing the forks to restart replication (PubMed:29670289). Its ability to promote degradation of nascent DNA at stalled replication forks is required to prevent induction of type I interferons, thereby preventing chronic inflammation (PubMed:27477283, PubMed:29670289). Ability to promote DNA end resection at stalled replication forks is independent of dNTPase activity (PubMed:29670289). Enhances immunoglobulin hypermutation in B-lymphocytes by promoting transversion mutation (By similarity). {ECO:0000250|UniProtKB:Q60710, ECO:0000269|PubMed:19525956, ECO:0000269|PubMed:21613998, ECO:0000269|PubMed:21720370, ECO:0000269|PubMed:22056990, ECO:0000269|PubMed:23364794, ECO:0000269|PubMed:23601106, ECO:0000269|PubMed:23602554, ECO:0000269|PubMed:23858451, ECO:0000269|PubMed:24035396, ECO:0000269|PubMed:24217394, ECO:0000269|PubMed:24336198, ECO:0000269|PubMed:25038827, ECO:0000269|PubMed:26101257, ECO:0000269|PubMed:26294762, ECO:0000269|PubMed:26431200, ECO:0000269|PubMed:27477283, ECO:0000269|PubMed:28229507, ECO:0000269|PubMed:28834754, ECO:0000269|PubMed:29610582, ECO:0000269|PubMed:29670289}. |
| Q9Y450 | HBS1L | S127 | ochoa | HBS1-like protein (EC 3.6.5.-) (ERFS) | GTPase component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:21448132, PubMed:23667253, PubMed:27863242). The Pelota-HBS1L complex recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel (PubMed:27863242). Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (PubMed:21448132, PubMed:32006463). {ECO:0000269|PubMed:21448132, ECO:0000269|PubMed:23667253, ECO:0000269|PubMed:27863242, ECO:0000269|PubMed:32006463}. |
| Q9Y490 | TLN1 | S1679 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| Q9Y4B6 | DCAF1 | S828 | ochoa | DDB1- and CUL4-associated factor 1 (HIV-1 Vpr-binding protein) (VprBP) (Serine/threonine-protein kinase VPRBP) (EC 2.7.11.1) (Vpr-interacting protein) | Acts both as a substrate recognition component of E3 ubiquitin-protein ligase complexes and as an atypical serine/threonine-protein kinase, playing key roles in various processes such as cell cycle, telomerase regulation and histone modification. Probable substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, named CUL4A-RBX1-DDB1-DCAF1/VPRBP complex, which mediates ubiquitination and proteasome-dependent degradation of proteins such as NF2 (PubMed:23063525). Involved in the turnover of methylated proteins: recognizes and binds methylated proteins via its chromo domain, leading to ubiquitination of target proteins by the RBX1-DDB1-DCAF1/VPRBP complex (PubMed:23063525). The CUL4A-RBX1-DDB1-DCAF1/VPRBP complex is also involved in B-cell development: DCAF1 is recruited by RAG1 to ubiquitinate proteins, leading to limit error-prone repair during V(D)J recombination (By similarity). Also part of the EDVP complex, an E3 ligase complex that mediates ubiquitination of proteins such as TERT, leading to TERT degradation and telomerase inhibition (PubMed:19287380, PubMed:23362280). The EDVP complex also mediates ubiquitination and degradation of CCP110 (PubMed:28242748, PubMed:34259627). Also acts as an atypical serine/threonine-protein kinase that specifically mediates phosphorylation of 'Thr-120' of histone H2A (H2AT120ph) in a nucleosomal context, thereby repressing transcription (PubMed:24140421). H2AT120ph is present in the regulatory region of many tumor suppresor genes, down-regulates their transcription and is present at high level in a number of tumors (PubMed:24140421). Involved in JNK-mediated apoptosis during cell competition process via its interaction with LLGL1 and LLGL2 (PubMed:20644714). By acting on TET dioxygenses, essential for oocyte maintenance at the primordial follicle stage, hence essential for female fertility (By similarity). {ECO:0000250|UniProtKB:Q80TR8, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:17609381, ECO:0000269|PubMed:17630831, ECO:0000269|PubMed:18332868, ECO:0000269|PubMed:18524771, ECO:0000269|PubMed:18606781, ECO:0000269|PubMed:19287380, ECO:0000269|PubMed:20644714, ECO:0000269|PubMed:22184063, ECO:0000269|PubMed:23063525, ECO:0000269|PubMed:23362280, ECO:0000269|PubMed:24140421, ECO:0000269|PubMed:28242748, ECO:0000269|PubMed:34259627}.; FUNCTION: (Microbial infection) In case of infection by HIV-1 virus, it is recruited by HIV-1 Vpr in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to arrest the cell cycle in G2 phase, and also to protect the viral protein from proteasomal degradation by another E3 ubiquitin ligase. The HIV-1 Vpr protein hijacks the CUL4A-RBX1-DDB1-DCAF1/VPRBP complex to promote ubiquitination and degradation of proteins such as TERT and ZIP/ZGPAT. {ECO:0000269|PubMed:17314515, ECO:0000269|PubMed:17559673, ECO:0000269|PubMed:17609381, ECO:0000269|PubMed:17620334, ECO:0000269|PubMed:17626091, ECO:0000269|PubMed:17630831, ECO:0000269|PubMed:18524771, ECO:0000269|PubMed:24116224}.; FUNCTION: (Microbial infection) In case of infection by HIV-2 virus, it is recruited by HIV-2 Vpx in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to enhanced efficiency of macrophage infection and promotion of the replication of cognate primate lentiviruses in cells of monocyte/macrophage lineage. {ECO:0000269|PubMed:17314515, ECO:0000269|PubMed:18464893, ECO:0000269|PubMed:19264781, ECO:0000269|PubMed:19923175, ECO:0000269|PubMed:24336198}. |
| Q9Y4E8 | USP15 | S78 | ochoa | Ubiquitin carboxyl-terminal hydrolase 15 (EC 3.4.19.12) (Deubiquitinating enzyme 15) (Ubiquitin thioesterase 15) (Ubiquitin-specific-processing protease 15) (Unph-2) (Unph4) | Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling, NF-kappa-B and RNF41/NRDP1-PRKN pathways (PubMed:16005295, PubMed:17318178, PubMed:19576224, PubMed:19826004, PubMed:21947082, PubMed:22344298, PubMed:24852371). Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes (PubMed:21947082). According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal (PubMed:22344298). Able to mediate deubiquitination of monoubiquitinated substrates, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:33093067). May also regulate gene expression and/or DNA repair through the deubiquitination of histone H2B (PubMed:24526689). Acts as an inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains attached by parkin on target proteins such as MFN2, thereby reducing parkin's ability to drive mitophagy (PubMed:24852371). Acts as an associated component of COP9 signalosome complex (CSN) and regulates different pathways via this association: regulates NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP (PubMed:16005295, PubMed:17318178, PubMed:19576224, PubMed:19826004). Involved in endosome organization by mediating deubiquitination of SQSTM1: ubiquitinated SQSTM1 forms a molecular bridge that restrains cognate vesicles in the perinuclear region and its deubiquitination releases target vesicles for fast transport into the cell periphery (PubMed:27368102). Acts as a negative regulator of antifungal immunity by mediating 'Lys-27'-linked deubiquitination of CARD9, thereby inactivating CARD9 (PubMed:33093067). {ECO:0000269|PubMed:16005295, ECO:0000269|PubMed:17318178, ECO:0000269|PubMed:19576224, ECO:0000269|PubMed:19826004, ECO:0000269|PubMed:21947082, ECO:0000269|PubMed:22344298, ECO:0000269|PubMed:24526689, ECO:0000269|PubMed:24852371, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:33093067}.; FUNCTION: (Microbial infection) Protects APC and human papillomavirus type 16 protein E6 against degradation via the ubiquitin proteasome pathway. {ECO:0000269|PubMed:19553310}. |
| P56192 | MARS1 | S812 | Sugiyama | Methionine--tRNA ligase, cytoplasmic (EC 6.1.1.10) (Methionyl-tRNA synthetase) (MetRS) | Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA (PubMed:11714285). Plays a role in the synthesis of ribosomal RNA in the nucleolus (PubMed:10791971). {ECO:0000269|PubMed:10791971, ECO:0000269|PubMed:11714285, ECO:0000269|PubMed:33909043}. |
| P05787 | KRT8 | S253 | Sugiyama | Keratin, type II cytoskeletal 8 (Cytokeratin-8) (CK-8) (Keratin-8) (K8) (Type-II keratin Kb8) | Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. {ECO:0000269|PubMed:16000376}. |
| Q12931 | TRAP1 | S482 | Sugiyama | Heat shock protein 75 kDa, mitochondrial (HSP 75) (Heat shock protein family C member 5) (TNFR-associated protein 1) (Tumor necrosis factor type 1 receptor-associated protein) (TRAP-1) | Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA. {ECO:0000269|PubMed:23525905, ECO:0000269|PubMed:23564345, ECO:0000269|PubMed:23747254}. |
| O15111 | CHUK | S123 | Sugiyama | Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16) | Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues (PubMed:18626576, PubMed:35952808, PubMed:9244310, PubMed:9252186, PubMed:9346484). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11) (PubMed:21765415). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes (PubMed:20501937). In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis. Also participates in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilizing MAP3K14/NIK. Within the nucleus, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities (PubMed:17434128). Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at 'Ser-10' that are subsequently acetylated at 'Lys-14' by CREBBP (PubMed:12789342). Additionally, phosphorylates the CREBBP-interacting protein NCOA3. Also phosphorylates FOXO3 and may regulate this pro-apoptotic transcription factor (PubMed:15084260). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates AMBRA1 following mitophagy induction, promoting AMBRA1 interaction with ATG8 family proteins and its mitophagic activity (PubMed:30217973). {ECO:0000250|UniProtKB:Q60680, ECO:0000269|PubMed:12789342, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17434128, ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20501937, ECO:0000269|PubMed:21765415, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35952808, ECO:0000269|PubMed:9244310, ECO:0000269|PubMed:9252186, ECO:0000269|PubMed:9346484, ECO:0000303|PubMed:18626576}. |
| O15111 | CHUK | S361 | Sugiyama | Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16) | Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues (PubMed:18626576, PubMed:35952808, PubMed:9244310, PubMed:9252186, PubMed:9346484). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11) (PubMed:21765415). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes (PubMed:20501937). In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis. Also participates in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilizing MAP3K14/NIK. Within the nucleus, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities (PubMed:17434128). Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at 'Ser-10' that are subsequently acetylated at 'Lys-14' by CREBBP (PubMed:12789342). Additionally, phosphorylates the CREBBP-interacting protein NCOA3. Also phosphorylates FOXO3 and may regulate this pro-apoptotic transcription factor (PubMed:15084260). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates AMBRA1 following mitophagy induction, promoting AMBRA1 interaction with ATG8 family proteins and its mitophagic activity (PubMed:30217973). {ECO:0000250|UniProtKB:Q60680, ECO:0000269|PubMed:12789342, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17434128, ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20501937, ECO:0000269|PubMed:21765415, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35952808, ECO:0000269|PubMed:9244310, ECO:0000269|PubMed:9252186, ECO:0000269|PubMed:9346484, ECO:0000303|PubMed:18626576}. |
| P04181 | OAT | Y69 | Sugiyama | Ornithine aminotransferase, mitochondrial (EC 2.6.1.13) (Ornithine delta-aminotransferase) (Ornithine--oxo-acid aminotransferase) [Cleaved into: Ornithine aminotransferase, hepatic form; Ornithine aminotransferase, renal form] | Catalyzes the reversible interconversion of L-ornithine and 2-oxoglutarate to L-glutamate semialdehyde and L-glutamate. {ECO:0000269|PubMed:1737786, ECO:0000269|PubMed:23076989}. |
| Q86X76 | NIT1 | Y300 | Sugiyama | Deaminated glutathione amidase (dGSH amidase) (EC 3.5.1.128) (Nitrilase homolog 1) | Catalyzes the hydrolysis of the amide bond in N-(4-oxoglutarate)-L-cysteinylglycine (deaminated glutathione), a metabolite repair reaction to dispose of the harmful deaminated glutathione. Plays a role in cell growth and apoptosis: loss of expression promotes cell growth, resistance to DNA damage stress and increased incidence to NMBA-induced tumors. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells; this effect is additive to the tumor suppressor activity of FHIT. It is also a negative regulator of primary T-cells. {ECO:0000250|UniProtKB:Q8VDK1}. |
| P11182 | DBT | Y208 | Sugiyama | Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial (EC 2.3.1.168) (52 kDa mitochondrial autoantigen of primary biliary cirrhosis) (Branched chain 2-oxo-acid dehydrogenase complex component E2) (BCOADC-E2) (Branched-chain alpha-keto acid dehydrogenase complex component E2) (BCKAD-E2) (BCKADE2) (BCKDH-E2) (Dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex) (Dihydrolipoamide branched chain transacylase) (Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase) | The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acyl groups that are generated by the branched-chain alpha-keto acid decarboxylase component. {ECO:0000250|UniProtKB:P11181}. |
| P07686 | HEXB | S261 | Sugiyama | Beta-hexosaminidase subunit beta (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit beta) (Hexosaminidase subunit B) (Cervical cancer proto-oncogene 7 protein) (HCC-7) (N-acetyl-beta-glucosaminidase subunit beta) [Cleaved into: Beta-hexosaminidase subunit beta chain B; Beta-hexosaminidase subunit beta chain A] | Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides (PubMed:11707436, PubMed:8123671, PubMed:8672428, PubMed:9694901). The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide (PubMed:11707436). Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A (PubMed:8123671, PubMed:8672428, PubMed:9694901). During fertilization is responsible, at least in part, for the zona block to polyspermy. Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and inactivates the sperm galactosyltransferase-binding site, accounting for the block in sperm binding to the zona pellucida (By similarity). {ECO:0000250|UniProtKB:P20060, ECO:0000269|PubMed:11707436, ECO:0000269|PubMed:8123671, ECO:0000269|PubMed:8672428, ECO:0000269|PubMed:9694901}. |
| P42680 | TEC | S591 | Sugiyama | Tyrosine-protein kinase Tec (EC 2.7.10.2) | Non-receptor tyrosine kinase that contributes to signaling from many receptors and participates as a signal transducer in multiple downstream pathways, including regulation of the actin cytoskeleton. Plays a redundant role to ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. Required for TCR-dependent IL2 gene induction. Phosphorylates DOK1, one CD28-specific substrate, and contributes to CD28-signaling. Mediates signals that negatively regulate IL2RA expression induced by TCR cross-linking. Plays a redundant role to BTK in BCR-signaling for B-cell development and activation, especially by phosphorylating STAP1, a BCR-signaling protein. Required in mast cells for efficient cytokine production. Involved in both growth and differentiation mechanisms of myeloid cells through activation by the granulocyte colony-stimulating factor CSF3, a critical cytokine to promoting the growth, differentiation, and functional activation of myeloid cells. Participates in platelet signaling downstream of integrin activation. Cooperates with JAK2 through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. GRB10, a negative modifier of the FOS activation pathway, is another substrate of TEC. TEC is involved in G protein-coupled receptor- and integrin-mediated signalings in blood platelets. Plays a role in hepatocyte proliferation and liver regeneration and is involved in HGF-induced ERK signaling pathway. TEC also regulates FGF2 unconventional secretion (endoplasmic reticulum (ER)/Golgi-independent mechanism) under various physiological conditions through phosphorylation of FGF2 'Tyr-215'. May also be involved in the regulation of osteoclast differentiation. {ECO:0000269|PubMed:10518561, ECO:0000269|PubMed:19883687, ECO:0000269|PubMed:20230531, ECO:0000269|PubMed:9753425}. |
| Q13131 | PRKAA1 | S65 | Sugiyama | 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26) | Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:17307971, PubMed:17712357, PubMed:24563466, PubMed:37821951). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (PubMed:17307971, PubMed:17712357). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (PubMed:17307971, PubMed:17712357). Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively (By similarity). Promotes lipolysis of lipid droplets by mediating phosphorylation of isoform 1 of CHKA (CHKalpha2) (PubMed:34077757). Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3 (By similarity). AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160 (By similarity). Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A (PubMed:11518699, PubMed:11554766, PubMed:15866171, PubMed:17711846, PubMed:18184930). Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm (By similarity). In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription (By similarity). Acts as a key regulator of cell growth and proliferation by phosphorylating FNIP1, TSC2, RPTOR, WDR24 and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2 (PubMed:14651849, PubMed:18439900, PubMed:20160076, PubMed:21205641). Also phosphorylates and inhibits GATOR2 subunit WDR24 in response to nutrient limitation, leading to suppress glucose-mediated mTORC1 activation (PubMed:36732624). In response to energetic stress, phosphorylates FNIP1, inactivating the non-canonical mTORC1 signaling, thereby promoting nuclear translocation of TFEB and TFE3, and inducing transcription of lysosomal or autophagy genes (PubMed:37079666). In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1 (PubMed:21205641). In that process, it also activates WDR45/WIPI4 (PubMed:28561066). Phosphorylates CASP6, thereby preventing its autoprocessing and subsequent activation (PubMed:32029622). In response to nutrient limitation, phosphorylates transcription factor FOXO3 promoting FOXO3 mitochondrial import (By similarity). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (PubMed:17486097). AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it (By similarity). May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it (By similarity). Also has tau-protein kinase activity: in response to amyloid beta A4 protein (APP) exposure, activated by CAMKK2, leading to phosphorylation of MAPT/TAU; however the relevance of such data remains unclear in vivo (By similarity). Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1 (PubMed:12519745, PubMed:20074060). Regulates hepatic lipogenesis. Activated via SIRT3, represses sterol regulatory element-binding protein (SREBP) transcriptional activities and ATP-consuming lipogenesis to restore cellular energy balance. Upon stress, regulates mitochondrial fragmentation through phosphorylation of MTFR1L (PubMed:36367943). {ECO:0000250|UniProtKB:P54645, ECO:0000250|UniProtKB:Q5EG47, ECO:0000269|PubMed:11518699, ECO:0000269|PubMed:11554766, ECO:0000269|PubMed:12519745, ECO:0000269|PubMed:14651849, ECO:0000269|PubMed:15866171, ECO:0000269|PubMed:17486097, ECO:0000269|PubMed:17711846, ECO:0000269|PubMed:18184930, ECO:0000269|PubMed:18439900, ECO:0000269|PubMed:20074060, ECO:0000269|PubMed:20160076, ECO:0000269|PubMed:21205641, ECO:0000269|PubMed:24563466, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:32029622, ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:36367943, ECO:0000269|PubMed:36732624, ECO:0000269|PubMed:37079666, ECO:0000269|PubMed:37821951, ECO:0000303|PubMed:17307971, ECO:0000303|PubMed:17712357}. |
| O60488 | ACSL4 | S584 | Sugiyama | Long-chain-fatty-acid--CoA ligase 4 (EC 6.2.1.3) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 4) (LACS 4) | Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:21242590, PubMed:22633490, PubMed:24269233). Preferentially activates arachidonate and eicosapentaenoate as substrates (PubMed:21242590). Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET. Modulates glucose-stimulated insulin secretion by regulating the levels of unesterified EETs (By similarity). Modulates prostaglandin E2 secretion (PubMed:21242590). {ECO:0000250|UniProtKB:O35547, ECO:0000269|PubMed:21242590, ECO:0000269|PubMed:22633490, ECO:0000269|PubMed:24269233}. |
| O95573 | ACSL3 | S593 | Sugiyama | Fatty acid CoA ligase Acsl3 (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 3) (LACS 3) (Long-chain-fatty-acid--CoA ligase 3) (EC 6.2.1.3) (Medium-chain acyl-CoA ligase Acsl3) (EC 6.2.1.2) | Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:22633490). Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins) (PubMed:18003621). Has mainly an anabolic role in energy metabolism. Mediates hepatic lipogenesis. Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates. Both isoforms exhibit the same level of activity (By similarity). {ECO:0000250|UniProtKB:Q63151, ECO:0000269|PubMed:18003621, ECO:0000269|PubMed:22633490}. |
| Q8N319 | LINC03040 | S78 | Sugiyama | Uncharacterized protein LINC03040 | None |
| O75116 | ROCK2 | S762 | Sugiyama | Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho kinase 2) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2) | Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation. {ECO:0000269|PubMed:10579722, ECO:0000269|PubMed:15699075, ECO:0000269|PubMed:16574662, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21147781}. |
| P61201 | COPS2 | S221 | Sugiyama | COP9 signalosome complex subunit 2 (SGN2) (Signalosome subunit 2) (Alien homolog) (JAB1-containing signalosome subunit 2) (Thyroid receptor-interacting protein 15) (TR-interacting protein 15) (TRIP-15) | Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}. |
| Q05048 | CSTF1 | S377 | Sugiyama | Cleavage stimulation factor subunit 1 (CF-1 50 kDa subunit) (Cleavage stimulation factor 50 kDa subunit) (CSTF 50 kDa subunit) (CstF-50) | One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs (PubMed:10669729). May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA (PubMed:10669729). {ECO:0000303|PubMed:10669729}. |
| P29590 | PML | S366 | Sugiyama | Protein PML (E3 SUMO-protein ligase PML) (EC 2.3.2.-) (Promyelocytic leukemia protein) (RING finger protein 71) (RING-type E3 SUMO transferase PML) (Tripartite motif-containing protein 19) (TRIM19) | Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Inhibits EIF4E-mediated mRNA nuclear export by reducing EIF4E affinity for the 5' 7-methylguanosine (m7G) cap of target mRNAs (PubMed:11500381, PubMed:11575918, PubMed:18391071). Isoform PML-4 has a multifaceted role in the regulation of apoptosis and growth suppression: activates RB1 and inhibits AKT1 via interactions with PP1 and PP2A phosphatases respectively, negatively affects the PI3K pathway by inhibiting MTOR and activating PTEN, and positively regulates p53/TP53 by acting at different levels (by promoting its acetylation and phosphorylation and by inhibiting its MDM2-dependent degradation). Isoform PML-4 also: acts as a transcriptional repressor of TBX2 during cellular senescence and the repression is dependent on a functional RBL2/E2F4 repressor complex, regulates double-strand break repair in gamma-irradiation-induced DNA damage responses via its interaction with WRN, acts as a negative regulator of telomerase by interacting with TERT, and regulates PER2 nuclear localization and circadian function. Isoform PML-6 inhibits specifically the activity of the tetrameric form of PKM. The nuclear isoforms (isoform PML-1, isoform PML-2, isoform PML-3, isoform PML-4 and isoform PML-5) in concert with SATB1 are involved in local chromatin-loop remodeling and gene expression regulation at the MHC-I locus. Isoform PML-2 is required for efficient IFN-gamma induced MHC II gene transcription via regulation of CIITA. Cytoplasmic PML is involved in the regulation of the TGF-beta signaling pathway. PML also regulates transcription activity of ELF4 and can act as an important mediator for TNF-alpha- and IFN-alpha-mediated inhibition of endothelial cell network formation and migration. {ECO:0000269|PubMed:11500381, ECO:0000269|PubMed:11575918, ECO:0000269|PubMed:18391071}.; FUNCTION: Exhibits antiviral activity against both DNA and RNA viruses. The antiviral activity can involve one or several isoform(s) and can be enhanced by the permanent PML-NB-associated protein DAXX or by the recruitment of p53/TP53 within these structures. Isoform PML-4 restricts varicella zoster virus (VZV) via sequestration of virion capsids in PML-NBs thereby preventing their nuclear egress and inhibiting formation of infectious virus particles. The sumoylated isoform PML-4 restricts rabies virus by inhibiting viral mRNA and protein synthesis. The cytoplasmic isoform PML-14 can restrict herpes simplex virus-1 (HHV-1) replication by sequestering the viral E3 ubiquitin-protein ligase ICP0 in the cytoplasm. Isoform PML-6 shows restriction activity towards human cytomegalovirus (HHV-5) and influenza A virus strains PR8(H1N1) and ST364(H3N2). Sumoylated isoform PML-4 and isoform PML-12 show antiviral activity against encephalomyocarditis virus (EMCV) by promoting nuclear sequestration of viral polymerase (P3D-POL) within PML NBs. Isoform PML-3 exhibits antiviral activity against poliovirus by inducing apoptosis in infected cells through the recruitment and the activation of p53/TP53 in the PML-NBs. Isoform PML-3 represses human foamy virus (HFV) transcription by complexing the HFV transactivator, bel1/tas, preventing its binding to viral DNA. PML may positively regulate infectious hepatitis C viral (HCV) production and isoform PML-2 may enhance adenovirus transcription. Functions as an E3 SUMO-protein ligase that sumoylates (HHV-5) immediate early protein IE1, thereby participating in the antiviral response (PubMed:20972456, PubMed:28250117). Isoforms PML-3 and PML-6 display the highest levels of sumoylation activity (PubMed:20972456, PubMed:28250117). {ECO:0000269|PubMed:20972456, ECO:0000269|PubMed:28250117}. |
| O60831 | PRAF2 | S19 | Sugiyama | PRA1 family protein 2 | May be involved in ER/Golgi transport and vesicular traffic. Plays a proapoptotic role in cerulenin-induced neuroblastoma apoptosis. {ECO:0000269|PubMed:17975142, ECO:0000269|PubMed:18395978}. |
| Q9Y4K4 | MAP4K5 | S60 | Sugiyama | Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (Kinase homologous to SPS1/STE20) (KHS) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) | May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. {ECO:0000269|PubMed:9038372}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-383280 | Nuclear Receptor transcription pathway | 6.918181e-08 | 7.160 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 7.119116e-05 | 4.148 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 7.087440e-05 | 4.150 |
| R-HSA-5357801 | Programmed Cell Death | 2.371514e-04 | 3.625 |
| R-HSA-109581 | Apoptosis | 4.469020e-04 | 3.350 |
| R-HSA-75153 | Apoptotic execution phase | 4.612281e-04 | 3.336 |
| R-HSA-5218900 | CASP8 activity is inhibited | 1.364129e-03 | 2.865 |
| R-HSA-1640170 | Cell Cycle | 1.452158e-03 | 2.838 |
| R-HSA-162582 | Signal Transduction | 1.539778e-03 | 2.813 |
| R-HSA-68877 | Mitotic Prometaphase | 1.651387e-03 | 2.782 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 2.562177e-03 | 2.591 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 2.562177e-03 | 2.591 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 3.069351e-03 | 2.513 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 3.069351e-03 | 2.513 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 3.069351e-03 | 2.513 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 3.069351e-03 | 2.513 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 3.069351e-03 | 2.513 |
| R-HSA-1266695 | Interleukin-7 signaling | 2.437372e-03 | 2.613 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 3.334838e-03 | 2.477 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 3.748545e-03 | 2.426 |
| R-HSA-69620 | Cell Cycle Checkpoints | 4.563512e-03 | 2.341 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 4.943458e-03 | 2.306 |
| R-HSA-4791275 | Signaling by WNT in cancer | 4.998619e-03 | 2.301 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 5.691560e-03 | 2.245 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 6.110335e-03 | 2.214 |
| R-HSA-68886 | M Phase | 6.231454e-03 | 2.205 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 6.501436e-03 | 2.187 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 7.381882e-03 | 2.132 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 8.280687e-03 | 2.082 |
| R-HSA-75158 | TRAIL signaling | 9.160754e-03 | 2.038 |
| R-HSA-69278 | Cell Cycle, Mitotic | 9.433238e-03 | 2.025 |
| R-HSA-451927 | Interleukin-2 family signaling | 1.034387e-02 | 1.985 |
| R-HSA-434313 | Intracellular metabolism of fatty acids regulates insulin secretion | 1.146021e-02 | 1.941 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 1.189174e-02 | 1.925 |
| R-HSA-5218859 | Regulated Necrosis | 1.213928e-02 | 1.916 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 1.271837e-02 | 1.896 |
| R-HSA-73887 | Death Receptor Signaling | 1.264561e-02 | 1.898 |
| R-HSA-9603381 | Activated NTRK3 signals through PI3K | 1.398528e-02 | 1.854 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 1.343916e-02 | 1.872 |
| R-HSA-446107 | Type I hemidesmosome assembly | 1.672736e-02 | 1.777 |
| R-HSA-3371378 | Regulation by c-FLIP | 1.672736e-02 | 1.777 |
| R-HSA-69416 | Dimerization of procaspase-8 | 1.672736e-02 | 1.777 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 1.555995e-02 | 1.808 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 1.541521e-02 | 1.812 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 1.541521e-02 | 1.812 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 1.672736e-02 | 1.777 |
| R-HSA-380287 | Centrosome maturation | 1.709142e-02 | 1.767 |
| R-HSA-5467343 | Deletions in the AMER1 gene destabilize the destruction complex | 1.760442e-02 | 1.754 |
| R-HSA-8851680 | Butyrophilin (BTN) family interactions | 1.967810e-02 | 1.706 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 1.997313e-02 | 1.700 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 2.162600e-02 | 1.665 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 2.162600e-02 | 1.665 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 2.056492e-02 | 1.687 |
| R-HSA-9700206 | Signaling by ALK in cancer | 2.056492e-02 | 1.687 |
| R-HSA-198203 | PI3K/AKT activation | 2.282934e-02 | 1.642 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 2.617317e-02 | 1.582 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 2.617317e-02 | 1.582 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 2.617317e-02 | 1.582 |
| R-HSA-9615710 | Late endosomal microautophagy | 2.514960e-02 | 1.599 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 2.617317e-02 | 1.582 |
| R-HSA-4839744 | Signaling by APC mutants | 2.617317e-02 | 1.582 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 2.617317e-02 | 1.582 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 2.702021e-02 | 1.568 |
| R-HSA-3656248 | Defective HEXB causes GM2G2 (Hyaluronan metabolism) | 3.489998e-02 | 1.457 |
| R-HSA-5603027 | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... | 5.189210e-02 | 1.285 |
| R-HSA-5619111 | Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) | 5.189210e-02 | 1.285 |
| R-HSA-5619096 | Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1) | 5.189210e-02 | 1.285 |
| R-HSA-9916720 | Mitochondrial short-chain enoyl-CoA hydratase deficiency 1 | 5.189210e-02 | 1.285 |
| R-HSA-5602636 | IKBKB deficiency causes SCID | 5.189210e-02 | 1.285 |
| R-HSA-5658034 | HHAT G278V doesn't palmitoylate Hh-Np | 6.858607e-02 | 1.164 |
| R-HSA-8941237 | Invadopodia formation | 8.498710e-02 | 1.071 |
| R-HSA-5679001 | Defective ABCC2 causes DJS | 8.498710e-02 | 1.071 |
| R-HSA-5579019 | Defective FMO3 causes TMAU | 1.011003e-01 | 0.995 |
| R-HSA-74713 | IRS activation | 1.169308e-01 | 0.932 |
| R-HSA-203754 | NOSIP mediated eNOS trafficking | 1.169308e-01 | 0.932 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 1.169308e-01 | 0.932 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 1.324834e-01 | 0.878 |
| R-HSA-9865113 | Loss-of-function mutations in DBT cause MSUD2 | 1.324834e-01 | 0.878 |
| R-HSA-5688849 | Defective CSF2RB causes SMDP5 | 1.324834e-01 | 0.878 |
| R-HSA-9907570 | Loss-of-function mutations in DLD cause MSUD3/DLDD | 1.324834e-01 | 0.878 |
| R-HSA-5688890 | Defective CSF2RA causes SMDP4 | 1.324834e-01 | 0.878 |
| R-HSA-9912529 | H139Hfs13* PPM1K causes a mild variant of MSUD | 1.477630e-01 | 0.830 |
| R-HSA-9865125 | Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD | 1.477630e-01 | 0.830 |
| R-HSA-9912481 | Branched-chain ketoacid dehydrogenase kinase deficiency | 1.477630e-01 | 0.830 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 1.627745e-01 | 0.788 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 1.627745e-01 | 0.788 |
| R-HSA-112412 | SOS-mediated signalling | 1.627745e-01 | 0.788 |
| R-HSA-9028335 | Activated NTRK2 signals through PI3K | 1.775224e-01 | 0.751 |
| R-HSA-9020958 | Interleukin-21 signaling | 1.920115e-01 | 0.717 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 2.062462e-01 | 0.686 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 2.202309e-01 | 0.657 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 9.467014e-02 | 1.024 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 2.339702e-01 | 0.631 |
| R-HSA-1250342 | PI3K events in ERBB4 signaling | 2.339702e-01 | 0.631 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 1.057744e-01 | 0.976 |
| R-HSA-9865114 | Maple Syrup Urine Disease | 2.474681e-01 | 0.606 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 1.289340e-01 | 0.890 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 1.289340e-01 | 0.890 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 3.893969e-02 | 1.410 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 3.893969e-02 | 1.410 |
| R-HSA-9859138 | BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV | 2.737571e-01 | 0.563 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 4.414000e-02 | 1.355 |
| R-HSA-390522 | Striated Muscle Contraction | 1.593113e-01 | 0.798 |
| R-HSA-5656121 | Translesion synthesis by POLI | 2.991309e-01 | 0.524 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 2.991309e-01 | 0.524 |
| R-HSA-5655862 | Translesion synthesis by POLK | 3.114845e-01 | 0.507 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 3.114845e-01 | 0.507 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 3.236211e-01 | 0.490 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 3.355445e-01 | 0.474 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 8.811111e-02 | 1.055 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 8.811111e-02 | 1.055 |
| R-HSA-5654710 | PI-3K cascade:FGFR3 | 3.472584e-01 | 0.459 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 3.472584e-01 | 0.459 |
| R-HSA-5654720 | PI-3K cascade:FGFR4 | 3.587665e-01 | 0.445 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 3.587665e-01 | 0.445 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 3.587665e-01 | 0.445 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 3.587665e-01 | 0.445 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 3.587665e-01 | 0.445 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 3.700725e-01 | 0.432 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 3.811798e-01 | 0.419 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 3.811798e-01 | 0.419 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 3.811798e-01 | 0.419 |
| R-HSA-5654689 | PI-3K cascade:FGFR1 | 3.920919e-01 | 0.407 |
| R-HSA-72649 | Translation initiation complex formation | 3.014670e-01 | 0.521 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 3.144765e-01 | 0.502 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 3.285736e-01 | 0.483 |
| R-HSA-72172 | mRNA Splicing | 3.669082e-01 | 0.435 |
| R-HSA-73886 | Chromosome Maintenance | 9.473305e-02 | 1.023 |
| R-HSA-180786 | Extension of Telomeres | 3.258272e-02 | 1.487 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 1.015044e-01 | 0.994 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 2.834675e-01 | 0.547 |
| R-HSA-157579 | Telomere Maintenance | 1.277871e-01 | 0.894 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 1.531302e-01 | 0.815 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 3.236211e-01 | 0.490 |
| R-HSA-8853659 | RET signaling | 1.781132e-01 | 0.749 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 1.169308e-01 | 0.932 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 7.360549e-02 | 1.133 |
| R-HSA-9762292 | Regulation of CDH11 function | 2.062462e-01 | 0.686 |
| R-HSA-110312 | Translesion synthesis by REV1 | 2.865564e-01 | 0.543 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 3.114845e-01 | 0.507 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 3.721851e-01 | 0.429 |
| R-HSA-5660668 | CLEC7A/inflammasome pathway | 1.324834e-01 | 0.878 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 2.474681e-01 | 0.606 |
| R-HSA-69166 | Removal of the Flap Intermediate | 2.737571e-01 | 0.563 |
| R-HSA-174430 | Telomere C-strand synthesis initiation | 2.865564e-01 | 0.543 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 3.114845e-01 | 0.507 |
| R-HSA-110320 | Translesion Synthesis by POLH | 3.472584e-01 | 0.459 |
| R-HSA-6803529 | FGFR2 alternative splicing | 3.920919e-01 | 0.407 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 4.986322e-02 | 1.302 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 3.472584e-01 | 0.459 |
| R-HSA-525793 | Myogenesis | 1.114522e-01 | 0.953 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 6.062012e-02 | 1.217 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 2.557056e-01 | 0.592 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 6.372926e-02 | 1.196 |
| R-HSA-190704 | Oligomerization of connexins into connexons | 5.189210e-02 | 1.285 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 1.011003e-01 | 0.995 |
| R-HSA-5635838 | Activation of SMO | 4.986322e-02 | 1.302 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 1.627745e-01 | 0.788 |
| R-HSA-2025928 | Calcineurin activates NFAT | 1.920115e-01 | 0.717 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 1.531302e-01 | 0.815 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 1.844555e-01 | 0.734 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 2.101148e-01 | 0.678 |
| R-HSA-5674135 | MAP2K and MAPK activation | 2.165875e-01 | 0.664 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 2.426291e-01 | 0.615 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 2.949460e-01 | 0.530 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 2.113659e-01 | 0.675 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 1.114522e-01 | 0.953 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 2.607291e-01 | 0.584 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 2.753391e-01 | 0.560 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 3.876642e-01 | 0.412 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 2.474681e-01 | 0.606 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 2.165875e-01 | 0.664 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 3.587665e-01 | 0.445 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 1.668939e-01 | 0.778 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 2.491646e-01 | 0.604 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 2.491646e-01 | 0.604 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 2.491646e-01 | 0.604 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 1.371247e-01 | 0.863 |
| R-HSA-9764561 | Regulation of CDH1 Function | 2.965040e-02 | 1.528 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 1.531302e-01 | 0.815 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 1.655378e-01 | 0.781 |
| R-HSA-9865118 | Diseases of branched-chain amino acid catabolism | 1.114522e-01 | 0.953 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 3.847612e-01 | 0.415 |
| R-HSA-9609646 | HCMV Infection | 3.478784e-01 | 0.459 |
| R-HSA-190827 | Transport of connexins along the secretory pathway | 5.189210e-02 | 1.285 |
| R-HSA-4839735 | Signaling by AXIN mutants | 2.970187e-02 | 1.527 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 1.324834e-01 | 0.878 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 1.627745e-01 | 0.788 |
| R-HSA-9927354 | Co-stimulation by ICOS | 1.775224e-01 | 0.751 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 1.920115e-01 | 0.717 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 1.289340e-01 | 0.890 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 2.737571e-01 | 0.563 |
| R-HSA-162588 | Budding and maturation of HIV virion | 1.409188e-01 | 0.851 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 2.865564e-01 | 0.543 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 2.865564e-01 | 0.543 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 5.981380e-02 | 1.223 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 1.655378e-01 | 0.781 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 7.326311e-02 | 1.135 |
| R-HSA-69481 | G2/M Checkpoints | 1.108945e-01 | 0.955 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 4.028122e-01 | 0.395 |
| R-HSA-9734767 | Developmental Cell Lineages | 6.807553e-02 | 1.167 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 3.467379e-01 | 0.460 |
| R-HSA-68882 | Mitotic Anaphase | 1.300424e-01 | 0.886 |
| R-HSA-3928664 | Ephrin signaling | 6.372926e-02 | 1.196 |
| R-HSA-182971 | EGFR downregulation | 1.409188e-01 | 0.851 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 1.320699e-01 | 0.879 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 2.907011e-01 | 0.537 |
| R-HSA-6802949 | Signaling by RAS mutants | 2.491646e-01 | 0.604 |
| R-HSA-112399 | IRS-mediated signalling | 3.209618e-01 | 0.494 |
| R-HSA-74749 | Signal attenuation | 2.062462e-01 | 0.686 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 2.865564e-01 | 0.543 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 3.355445e-01 | 0.474 |
| R-HSA-912631 | Regulation of signaling by CBL | 3.472584e-01 | 0.459 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 2.230779e-01 | 0.652 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 2.426291e-01 | 0.615 |
| R-HSA-9842663 | Signaling by LTK | 3.340796e-02 | 1.476 |
| R-HSA-8851907 | MET activates PI3K/AKT signaling | 1.627745e-01 | 0.788 |
| R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 1.627745e-01 | 0.788 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 1.908298e-01 | 0.719 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 2.165875e-01 | 0.664 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 2.165875e-01 | 0.664 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 1.626094e-01 | 0.789 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 2.818803e-01 | 0.550 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 2.884165e-01 | 0.540 |
| R-HSA-74751 | Insulin receptor signalling cascade | 3.658585e-01 | 0.437 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 8.439111e-02 | 1.074 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 3.811798e-01 | 0.419 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 3.079777e-01 | 0.511 |
| R-HSA-2467813 | Separation of Sister Chromatids | 2.244007e-01 | 0.649 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 7.262139e-02 | 1.139 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 1.247362e-01 | 0.904 |
| R-HSA-2428924 | IGF1R signaling cascade | 3.658585e-01 | 0.437 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 3.467379e-01 | 0.460 |
| R-HSA-195721 | Signaling by WNT | 2.073888e-01 | 0.683 |
| R-HSA-5617833 | Cilium Assembly | 8.154089e-02 | 1.089 |
| R-HSA-205025 | NADE modulates death signalling | 1.011003e-01 | 0.995 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 1.920115e-01 | 0.717 |
| R-HSA-217271 | FMO oxidises nucleophiles | 2.339702e-01 | 0.631 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 2.865564e-01 | 0.543 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 2.865564e-01 | 0.543 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 3.114845e-01 | 0.507 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 8.301021e-02 | 1.081 |
| R-HSA-9834899 | Specification of the neural plate border | 3.472584e-01 | 0.459 |
| R-HSA-429958 | mRNA decay by 3' to 5' exoribonuclease | 3.472584e-01 | 0.459 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 3.472584e-01 | 0.459 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 3.700725e-01 | 0.432 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 1.755605e-01 | 0.756 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 2.491646e-01 | 0.604 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 2.068021e-01 | 0.684 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 2.818803e-01 | 0.550 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 3.144765e-01 | 0.502 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 3.274320e-01 | 0.485 |
| R-HSA-6809371 | Formation of the cornified envelope | 2.314942e-01 | 0.635 |
| R-HSA-5632684 | Hedgehog 'on' state | 5.362998e-02 | 1.271 |
| R-HSA-9824272 | Somitogenesis | 2.426291e-01 | 0.615 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 3.721851e-01 | 0.429 |
| R-HSA-9610379 | HCMV Late Events | 3.771056e-01 | 0.424 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 1.668939e-01 | 0.778 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 2.202622e-01 | 0.657 |
| R-HSA-9693928 | Defective RIPK1-mediated regulated necrosis | 2.062462e-01 | 0.686 |
| R-HSA-9766229 | Degradation of CDH1 | 8.226196e-02 | 1.085 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 2.865564e-01 | 0.543 |
| R-HSA-75893 | TNF signaling | 1.067233e-01 | 0.972 |
| R-HSA-5687613 | Diseases associated with surfactant metabolism | 2.474681e-01 | 0.606 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 2.737571e-01 | 0.563 |
| R-HSA-9673770 | Signaling by PDGFRA extracellular domain mutants | 2.865564e-01 | 0.543 |
| R-HSA-9673767 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 2.865564e-01 | 0.543 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 1.718063e-01 | 0.765 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 1.972331e-01 | 0.705 |
| R-HSA-2022857 | Keratan sulfate degradation | 3.587665e-01 | 0.445 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 2.295833e-01 | 0.639 |
| R-HSA-69186 | Lagging Strand Synthesis | 3.700725e-01 | 0.432 |
| R-HSA-114608 | Platelet degranulation | 1.108945e-01 | 0.955 |
| R-HSA-9020702 | Interleukin-1 signaling | 3.203876e-01 | 0.494 |
| R-HSA-9612973 | Autophagy | 9.219031e-02 | 1.035 |
| R-HSA-438064 | Post NMDA receptor activation events | 2.438693e-01 | 0.613 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 3.252117e-01 | 0.488 |
| R-HSA-75108 | Activation, myristolyation of BID and translocation to mitochondria | 6.858607e-02 | 1.164 |
| R-HSA-427652 | Sodium-coupled phosphate cotransporters | 1.324834e-01 | 0.878 |
| R-HSA-5632681 | Ligand-receptor interactions | 1.324834e-01 | 0.878 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 3.728413e-02 | 1.428 |
| R-HSA-9842640 | Signaling by LTK in cancer | 1.477630e-01 | 0.830 |
| R-HSA-8948747 | Regulation of PTEN localization | 1.627745e-01 | 0.788 |
| R-HSA-201688 | WNT mediated activation of DVL | 1.920115e-01 | 0.717 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 8.393356e-02 | 1.076 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 8.925339e-02 | 1.049 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 2.339702e-01 | 0.631 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 2.474681e-01 | 0.606 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 2.474681e-01 | 0.606 |
| R-HSA-9796292 | Formation of axial mesoderm | 2.607291e-01 | 0.584 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 2.737571e-01 | 0.563 |
| R-HSA-77350 | Beta oxidation of hexanoyl-CoA to butanoyl-CoA | 2.737571e-01 | 0.563 |
| R-HSA-77310 | Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA | 2.737571e-01 | 0.563 |
| R-HSA-77348 | Beta oxidation of octanoyl-CoA to hexanoyl-CoA | 2.737571e-01 | 0.563 |
| R-HSA-77352 | Beta oxidation of butanoyl-CoA to acetyl-CoA | 2.865564e-01 | 0.543 |
| R-HSA-9857492 | Protein lipoylation | 2.865564e-01 | 0.543 |
| R-HSA-190861 | Gap junction assembly | 1.655378e-01 | 0.781 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 3.811798e-01 | 0.419 |
| R-HSA-445355 | Smooth Muscle Contraction | 2.949460e-01 | 0.530 |
| R-HSA-202424 | Downstream TCR signaling | 2.580419e-01 | 0.588 |
| R-HSA-5358351 | Signaling by Hedgehog | 1.441410e-01 | 0.841 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 1.257187e-01 | 0.901 |
| R-HSA-177929 | Signaling by EGFR | 1.067233e-01 | 0.972 |
| R-HSA-70895 | Branched-chain amino acid catabolism | 2.818803e-01 | 0.550 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 4.095762e-01 | 0.388 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 4.095762e-01 | 0.388 |
| R-HSA-9686347 | Microbial modulation of RIPK1-mediated regulated necrosis | 1.627745e-01 | 0.788 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 3.236211e-01 | 0.490 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 2.036624e-01 | 0.691 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 3.810984e-01 | 0.419 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 7.898947e-02 | 1.102 |
| R-HSA-69275 | G2/M Transition | 7.541817e-02 | 1.123 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 3.599220e-01 | 0.444 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 1.282966e-01 | 0.892 |
| R-HSA-379724 | tRNA Aminoacylation | 3.403214e-01 | 0.468 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 7.844453e-02 | 1.105 |
| R-HSA-6794361 | Neurexins and neuroligins | 9.242093e-02 | 1.034 |
| R-HSA-446728 | Cell junction organization | 2.807180e-01 | 0.552 |
| R-HSA-1500931 | Cell-Cell communication | 3.958953e-02 | 1.402 |
| R-HSA-75157 | FasL/ CD95L signaling | 8.498710e-02 | 1.071 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 1.324834e-01 | 0.878 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 3.728413e-02 | 1.428 |
| R-HSA-391160 | Signal regulatory protein family interactions | 4.132330e-02 | 1.384 |
| R-HSA-426486 | Small interfering RNA (siRNA) biogenesis | 1.477630e-01 | 0.830 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 2.737571e-01 | 0.563 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 2.865564e-01 | 0.543 |
| R-HSA-77346 | Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA | 3.114845e-01 | 0.507 |
| R-HSA-416482 | G alpha (12/13) signalling events | 6.862174e-02 | 1.164 |
| R-HSA-2028269 | Signaling by Hippo | 3.236211e-01 | 0.490 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 3.236211e-01 | 0.490 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 3.587665e-01 | 0.445 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 1.626094e-01 | 0.789 |
| R-HSA-190828 | Gap junction trafficking | 2.361012e-01 | 0.627 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 1.701008e-01 | 0.769 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 2.344934e-01 | 0.630 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 3.338857e-01 | 0.476 |
| R-HSA-1234174 | Cellular response to hypoxia | 3.721851e-01 | 0.429 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 2.068021e-01 | 0.684 |
| R-HSA-199991 | Membrane Trafficking | 3.035388e-01 | 0.518 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 3.306510e-02 | 1.481 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 5.763704e-02 | 1.239 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 5.435075e-02 | 1.265 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 2.865564e-01 | 0.543 |
| R-HSA-180292 | GAB1 signalosome | 3.355445e-01 | 0.474 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 3.355445e-01 | 0.474 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 3.920919e-01 | 0.407 |
| R-HSA-201451 | Signaling by BMP | 1.172078e-01 | 0.931 |
| R-HSA-5358508 | Mismatch Repair | 3.355445e-01 | 0.474 |
| R-HSA-449836 | Other interleukin signaling | 3.472584e-01 | 0.459 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 2.894430e-01 | 0.538 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 1.025736e-01 | 0.989 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 4.707046e-02 | 1.327 |
| R-HSA-373755 | Semaphorin interactions | 1.336355e-01 | 0.874 |
| R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 1.324834e-01 | 0.878 |
| R-HSA-71288 | Creatine metabolism | 7.360549e-02 | 1.133 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 3.236211e-01 | 0.490 |
| R-HSA-9694548 | Maturation of spike protein | 2.101148e-01 | 0.678 |
| R-HSA-75876 | Synthesis of very long-chain fatty acyl-CoAs | 2.295833e-01 | 0.639 |
| R-HSA-211979 | Eicosanoids | 3.811798e-01 | 0.419 |
| R-HSA-157858 | Gap junction trafficking and regulation | 2.687949e-01 | 0.571 |
| R-HSA-109704 | PI3K Cascade | 2.753391e-01 | 0.560 |
| R-HSA-9645723 | Diseases of programmed cell death | 2.485800e-01 | 0.605 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 2.295833e-01 | 0.639 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 1.133075e-01 | 0.946 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 8.393356e-02 | 1.076 |
| R-HSA-114452 | Activation of BH3-only proteins | 1.348961e-01 | 0.870 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 1.247362e-01 | 0.904 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 1.499875e-01 | 0.824 |
| R-HSA-1632852 | Macroautophagy | 1.523662e-01 | 0.817 |
| R-HSA-373753 | Nephrin family interactions | 7.360549e-02 | 1.133 |
| R-HSA-9823730 | Formation of definitive endoderm | 3.587665e-01 | 0.445 |
| R-HSA-202403 | TCR signaling | 1.735418e-01 | 0.761 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 3.893969e-02 | 1.410 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 3.811798e-01 | 0.419 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 3.011067e-01 | 0.521 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 1.296555e-01 | 0.887 |
| R-HSA-9675135 | Diseases of DNA repair | 2.491646e-01 | 0.604 |
| R-HSA-9675108 | Nervous system development | 2.773436e-01 | 0.557 |
| R-HSA-9694631 | Maturation of nucleoprotein | 6.860809e-02 | 1.164 |
| R-HSA-201556 | Signaling by ALK | 4.964695e-02 | 1.304 |
| R-HSA-6814848 | Glycerophospholipid catabolism | 2.737571e-01 | 0.563 |
| R-HSA-193648 | NRAGE signals death through JNK | 1.067233e-01 | 0.972 |
| R-HSA-975578 | Reactions specific to the complex N-glycan synthesis pathway | 3.920919e-01 | 0.407 |
| R-HSA-2682334 | EPH-Ephrin signaling | 2.723222e-01 | 0.565 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 3.011067e-01 | 0.521 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 8.191755e-02 | 1.087 |
| R-HSA-1266738 | Developmental Biology | 2.566378e-01 | 0.591 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 3.355445e-01 | 0.474 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 2.101148e-01 | 0.678 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 2.818803e-01 | 0.550 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 3.383998e-01 | 0.471 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 1.875406e-01 | 0.727 |
| R-HSA-5683057 | MAPK family signaling cascades | 1.217003e-01 | 0.915 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 1.718063e-01 | 0.765 |
| R-HSA-70171 | Glycolysis | 3.155642e-01 | 0.501 |
| R-HSA-194138 | Signaling by VEGF | 1.061472e-01 | 0.974 |
| R-HSA-400451 | Free fatty acids regulate insulin secretion | 9.467014e-02 | 1.024 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 2.991309e-01 | 0.524 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 4.781287e-02 | 1.320 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 2.298302e-01 | 0.639 |
| R-HSA-449147 | Signaling by Interleukins | 1.782945e-01 | 0.749 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 1.908298e-01 | 0.719 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 4.034169e-01 | 0.394 |
| R-HSA-9831926 | Nephron development | 6.372926e-02 | 1.196 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 2.991309e-01 | 0.524 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 5.771202e-02 | 1.239 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 1.920115e-01 | 0.717 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 3.522343e-02 | 1.453 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 3.745279e-02 | 1.427 |
| R-HSA-391908 | Prostanoid ligand receptors | 2.202309e-01 | 0.657 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 2.474681e-01 | 0.606 |
| R-HSA-9683610 | Maturation of nucleoprotein | 2.607291e-01 | 0.584 |
| R-HSA-8963896 | HDL assembly | 2.737571e-01 | 0.563 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 3.236211e-01 | 0.490 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 3.236211e-01 | 0.490 |
| R-HSA-9012852 | Signaling by NOTCH3 | 1.030699e-01 | 0.987 |
| R-HSA-2586552 | Signaling by Leptin | 2.062462e-01 | 0.686 |
| R-HSA-9020558 | Interleukin-2 signaling | 2.202309e-01 | 0.657 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 3.920919e-01 | 0.407 |
| R-HSA-1433557 | Signaling by SCF-KIT | 2.295833e-01 | 0.639 |
| R-HSA-69206 | G1/S Transition | 2.390600e-01 | 0.621 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 1.908298e-01 | 0.719 |
| R-HSA-9843745 | Adipogenesis | 2.659624e-01 | 0.575 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 3.634340e-01 | 0.440 |
| R-HSA-9694635 | Translation of Structural Proteins | 6.636005e-02 | 1.178 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 3.700725e-01 | 0.432 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 3.700725e-01 | 0.432 |
| R-HSA-9754706 | Atorvastatin ADME | 2.991309e-01 | 0.524 |
| R-HSA-5633007 | Regulation of TP53 Activity | 4.138742e-02 | 1.383 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 1.668939e-01 | 0.778 |
| R-HSA-9830369 | Kidney development | 1.499648e-01 | 0.824 |
| R-HSA-74160 | Gene expression (Transcription) | 1.351743e-01 | 0.869 |
| R-HSA-1236394 | Signaling by ERBB4 | 1.799404e-01 | 0.745 |
| R-HSA-9669938 | Signaling by KIT in disease | 3.920919e-01 | 0.407 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 2.391735e-01 | 0.621 |
| R-HSA-69205 | G1/S-Specific Transcription | 1.781132e-01 | 0.749 |
| R-HSA-210993 | Tie2 Signaling | 3.355445e-01 | 0.474 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 3.920919e-01 | 0.407 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 3.209618e-01 | 0.494 |
| R-HSA-156711 | Polo-like kinase mediated events | 3.355445e-01 | 0.474 |
| R-HSA-391903 | Eicosanoid ligand-binding receptors | 3.587665e-01 | 0.445 |
| R-HSA-3000170 | Syndecan interactions | 4.028122e-01 | 0.395 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 1.067233e-01 | 0.972 |
| R-HSA-212436 | Generic Transcription Pathway | 1.349221e-01 | 0.870 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 1.972331e-01 | 0.705 |
| R-HSA-73857 | RNA Polymerase II Transcription | 2.162901e-01 | 0.665 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 3.331265e-01 | 0.477 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 2.036624e-01 | 0.691 |
| R-HSA-70263 | Gluconeogenesis | 2.622497e-01 | 0.581 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 1.099647e-01 | 0.959 |
| R-HSA-2162123 | Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | 2.753391e-01 | 0.560 |
| R-HSA-189200 | Cellular hexose transport | 3.920919e-01 | 0.407 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 4.028122e-01 | 0.395 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 2.128132e-01 | 0.672 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 3.595077e-01 | 0.444 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 2.740674e-01 | 0.562 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 1.376575e-01 | 0.861 |
| R-HSA-5620971 | Pyroptosis | 1.230364e-01 | 0.910 |
| R-HSA-163685 | Integration of energy metabolism | 2.894430e-01 | 0.538 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 1.339818e-01 | 0.873 |
| R-HSA-186712 | Regulation of beta-cell development | 3.258272e-02 | 1.487 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 3.338857e-01 | 0.476 |
| R-HSA-982772 | Growth hormone receptor signaling | 4.028122e-01 | 0.395 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 6.372926e-02 | 1.196 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 8.925339e-02 | 1.049 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 3.274320e-01 | 0.485 |
| R-HSA-1592230 | Mitochondrial biogenesis | 4.113669e-01 | 0.386 |
| R-HSA-70326 | Glucose metabolism | 4.113669e-01 | 0.386 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 4.133441e-01 | 0.384 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 4.133441e-01 | 0.384 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 4.133441e-01 | 0.384 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 4.133441e-01 | 0.384 |
| R-HSA-8863678 | Neurodegenerative Diseases | 4.133441e-01 | 0.384 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 4.133441e-01 | 0.384 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 4.133441e-01 | 0.384 |
| R-HSA-8963898 | Plasma lipoprotein assembly | 4.133441e-01 | 0.384 |
| R-HSA-5693538 | Homology Directed Repair | 4.160750e-01 | 0.381 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 4.160750e-01 | 0.381 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 4.207709e-01 | 0.376 |
| R-HSA-4086398 | Ca2+ pathway | 4.218006e-01 | 0.375 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 4.232204e-01 | 0.373 |
| R-HSA-5654695 | PI-3K cascade:FGFR2 | 4.236910e-01 | 0.373 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 4.236910e-01 | 0.373 |
| R-HSA-9620244 | Long-term potentiation | 4.236910e-01 | 0.373 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 4.236910e-01 | 0.373 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 4.236910e-01 | 0.373 |
| R-HSA-2160916 | Hyaluronan degradation | 4.236910e-01 | 0.373 |
| R-HSA-3214842 | HDMs demethylate histones | 4.236910e-01 | 0.373 |
| R-HSA-9830364 | Formation of the nephric duct | 4.236910e-01 | 0.373 |
| R-HSA-3000157 | Laminin interactions | 4.236910e-01 | 0.373 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 4.338560e-01 | 0.363 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 4.338560e-01 | 0.363 |
| R-HSA-2046105 | Linoleic acid (LA) metabolism | 4.338560e-01 | 0.363 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 4.338560e-01 | 0.363 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 4.338560e-01 | 0.363 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 4.338942e-01 | 0.363 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 4.338942e-01 | 0.363 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 4.338942e-01 | 0.363 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 4.365522e-01 | 0.360 |
| R-HSA-5689603 | UCH proteinases | 4.398901e-01 | 0.357 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 4.404672e-01 | 0.356 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 4.438423e-01 | 0.353 |
| R-HSA-171306 | Packaging Of Telomere Ends | 4.438423e-01 | 0.353 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 4.438423e-01 | 0.353 |
| R-HSA-8949613 | Cristae formation | 4.438423e-01 | 0.353 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 4.438423e-01 | 0.353 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 4.438423e-01 | 0.353 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 4.438423e-01 | 0.353 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 4.438423e-01 | 0.353 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 4.438423e-01 | 0.353 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 4.438423e-01 | 0.353 |
| R-HSA-264876 | Insulin processing | 4.438423e-01 | 0.353 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 4.438423e-01 | 0.353 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 4.443744e-01 | 0.352 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 4.443744e-01 | 0.352 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 4.458512e-01 | 0.351 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 4.481844e-01 | 0.349 |
| R-HSA-4086400 | PCP/CE pathway | 4.517769e-01 | 0.345 |
| R-HSA-5619084 | ABC transporter disorders | 4.517769e-01 | 0.345 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 4.521639e-01 | 0.345 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 4.536530e-01 | 0.343 |
| R-HSA-171319 | Telomere Extension By Telomerase | 4.536530e-01 | 0.343 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 4.576665e-01 | 0.339 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 4.632913e-01 | 0.334 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 4.632913e-01 | 0.334 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 4.632913e-01 | 0.334 |
| R-HSA-5334118 | DNA methylation | 4.632913e-01 | 0.334 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 4.632913e-01 | 0.334 |
| R-HSA-9006335 | Signaling by Erythropoietin | 4.632913e-01 | 0.334 |
| R-HSA-209968 | Thyroxine biosynthesis | 4.632913e-01 | 0.334 |
| R-HSA-180024 | DARPP-32 events | 4.632913e-01 | 0.334 |
| R-HSA-5654738 | Signaling by FGFR2 | 4.635195e-01 | 0.334 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 4.693353e-01 | 0.329 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 4.727602e-01 | 0.325 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 4.727602e-01 | 0.325 |
| R-HSA-68962 | Activation of the pre-replicative complex | 4.727602e-01 | 0.325 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 4.727602e-01 | 0.325 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 4.727602e-01 | 0.325 |
| R-HSA-2424491 | DAP12 signaling | 4.727602e-01 | 0.325 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 4.727602e-01 | 0.325 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 4.808534e-01 | 0.318 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 4.815566e-01 | 0.317 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 4.820625e-01 | 0.317 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 4.820625e-01 | 0.317 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 4.820625e-01 | 0.317 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 4.820625e-01 | 0.317 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 4.820625e-01 | 0.317 |
| R-HSA-186763 | Downstream signal transduction | 4.820625e-01 | 0.317 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 4.865548e-01 | 0.313 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 4.882209e-01 | 0.311 |
| R-HSA-9937080 | Developmental Lineage of Multipotent Pancreatic Progenitor Cells | 4.912013e-01 | 0.309 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 4.912013e-01 | 0.309 |
| R-HSA-69190 | DNA strand elongation | 4.912013e-01 | 0.309 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 4.912013e-01 | 0.309 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 4.912013e-01 | 0.309 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 4.922172e-01 | 0.308 |
| R-HSA-1500620 | Meiosis | 4.922172e-01 | 0.308 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 4.922172e-01 | 0.308 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 5.001794e-01 | 0.301 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 5.001794e-01 | 0.301 |
| R-HSA-354192 | Integrin signaling | 5.001794e-01 | 0.301 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 5.001794e-01 | 0.301 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 5.001794e-01 | 0.301 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 5.001794e-01 | 0.301 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 5.001794e-01 | 0.301 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 5.001794e-01 | 0.301 |
| R-HSA-9930044 | Nuclear RNA decay | 5.001794e-01 | 0.301 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 5.001794e-01 | 0.301 |
| R-HSA-9733709 | Cardiogenesis | 5.001794e-01 | 0.301 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 5.034233e-01 | 0.298 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 5.089997e-01 | 0.293 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 5.089997e-01 | 0.293 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 5.089997e-01 | 0.293 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 5.089997e-01 | 0.293 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 5.089997e-01 | 0.293 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 5.089997e-01 | 0.293 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 5.089997e-01 | 0.293 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 5.089997e-01 | 0.293 |
| R-HSA-2024101 | CS/DS degradation | 5.089997e-01 | 0.293 |
| R-HSA-8964539 | Glutamate and glutamine metabolism | 5.089997e-01 | 0.293 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 5.089997e-01 | 0.293 |
| R-HSA-189483 | Heme degradation | 5.089997e-01 | 0.293 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 5.142916e-01 | 0.289 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 5.167355e-01 | 0.287 |
| R-HSA-5696400 | Dual Incision in GG-NER | 5.176648e-01 | 0.286 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 5.176648e-01 | 0.286 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 5.176648e-01 | 0.286 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 5.176648e-01 | 0.286 |
| R-HSA-180746 | Nuclear import of Rev protein | 5.176648e-01 | 0.286 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 5.176648e-01 | 0.286 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 5.176648e-01 | 0.286 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 5.176648e-01 | 0.286 |
| R-HSA-2142845 | Hyaluronan metabolism | 5.176648e-01 | 0.286 |
| R-HSA-203615 | eNOS activation | 5.176648e-01 | 0.286 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 5.176648e-01 | 0.286 |
| R-HSA-1236974 | ER-Phagosome pathway | 5.199308e-01 | 0.284 |
| R-HSA-9948299 | Ribosome-associated quality control | 5.201244e-01 | 0.284 |
| R-HSA-6807070 | PTEN Regulation | 5.244259e-01 | 0.280 |
| R-HSA-73884 | Base Excision Repair | 5.253516e-01 | 0.280 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 5.261775e-01 | 0.279 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 5.261775e-01 | 0.279 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 5.261775e-01 | 0.279 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 5.261775e-01 | 0.279 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 5.261775e-01 | 0.279 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 5.261775e-01 | 0.279 |
| R-HSA-169911 | Regulation of Apoptosis | 5.261775e-01 | 0.279 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 5.261775e-01 | 0.279 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 5.307311e-01 | 0.275 |
| R-HSA-9609690 | HCMV Early Events | 5.314229e-01 | 0.275 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 5.314229e-01 | 0.275 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 5.345405e-01 | 0.272 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 5.345405e-01 | 0.272 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 5.345405e-01 | 0.272 |
| R-HSA-3371511 | HSF1 activation | 5.345405e-01 | 0.272 |
| R-HSA-114604 | GPVI-mediated activation cascade | 5.345405e-01 | 0.272 |
| R-HSA-9682385 | FLT3 signaling in disease | 5.345405e-01 | 0.272 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 5.345405e-01 | 0.272 |
| R-HSA-381070 | IRE1alpha activates chaperones | 5.360691e-01 | 0.271 |
| R-HSA-74752 | Signaling by Insulin receptor | 5.413654e-01 | 0.267 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 5.414183e-01 | 0.266 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 5.427564e-01 | 0.265 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 5.427564e-01 | 0.265 |
| R-HSA-4641258 | Degradation of DVL | 5.427564e-01 | 0.265 |
| R-HSA-4641257 | Degradation of AXIN | 5.427564e-01 | 0.265 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 5.427564e-01 | 0.265 |
| R-HSA-110331 | Cleavage of the damaged purine | 5.427564e-01 | 0.265 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 5.435308e-01 | 0.265 |
| R-HSA-389948 | Co-inhibition by PD-1 | 5.458890e-01 | 0.263 |
| R-HSA-73927 | Depurination | 5.508277e-01 | 0.259 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 5.508277e-01 | 0.259 |
| R-HSA-2046106 | alpha-linolenic acid (ALA) metabolism | 5.508277e-01 | 0.259 |
| R-HSA-422475 | Axon guidance | 5.509750e-01 | 0.259 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 5.518320e-01 | 0.258 |
| R-HSA-1474290 | Collagen formation | 5.518320e-01 | 0.258 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 5.570021e-01 | 0.254 |
| R-HSA-8953854 | Metabolism of RNA | 5.583385e-01 | 0.253 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 5.587571e-01 | 0.253 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 5.587571e-01 | 0.253 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 5.587571e-01 | 0.253 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 5.587571e-01 | 0.253 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 5.587571e-01 | 0.253 |
| R-HSA-69541 | Stabilization of p53 | 5.587571e-01 | 0.253 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 5.587571e-01 | 0.253 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 5.621298e-01 | 0.250 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 5.665470e-01 | 0.247 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 5.665470e-01 | 0.247 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 5.665470e-01 | 0.247 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 5.665470e-01 | 0.247 |
| R-HSA-5260271 | Diseases of Immune System | 5.665470e-01 | 0.247 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 5.665470e-01 | 0.247 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 5.665470e-01 | 0.247 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 5.665470e-01 | 0.247 |
| R-HSA-9646399 | Aggrephagy | 5.665470e-01 | 0.247 |
| R-HSA-202433 | Generation of second messenger molecules | 5.665470e-01 | 0.247 |
| R-HSA-975576 | N-glycan antennae elongation in the medial/trans-Golgi | 5.665470e-01 | 0.247 |
| R-HSA-6805567 | Keratinization | 5.706386e-01 | 0.244 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 5.708284e-01 | 0.243 |
| R-HSA-9679506 | SARS-CoV Infections | 5.732537e-01 | 0.242 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 5.741998e-01 | 0.241 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 5.741998e-01 | 0.241 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 5.741998e-01 | 0.241 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 5.741998e-01 | 0.241 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 5.741998e-01 | 0.241 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 5.741998e-01 | 0.241 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 5.741998e-01 | 0.241 |
| R-HSA-9607240 | FLT3 Signaling | 5.741998e-01 | 0.241 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 5.772576e-01 | 0.239 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 5.772576e-01 | 0.239 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 5.772576e-01 | 0.239 |
| R-HSA-190236 | Signaling by FGFR | 5.772576e-01 | 0.239 |
| R-HSA-422356 | Regulation of insulin secretion | 5.772576e-01 | 0.239 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 5.782399e-01 | 0.238 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 5.817180e-01 | 0.235 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 5.817180e-01 | 0.235 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 5.817180e-01 | 0.235 |
| R-HSA-6811438 | Intra-Golgi traffic | 5.817180e-01 | 0.235 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 5.817180e-01 | 0.235 |
| R-HSA-9683701 | Translation of Structural Proteins | 5.817180e-01 | 0.235 |
| R-HSA-446652 | Interleukin-1 family signaling | 5.823273e-01 | 0.235 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 5.862897e-01 | 0.232 |
| R-HSA-5610787 | Hedgehog 'off' state | 5.871293e-01 | 0.231 |
| R-HSA-382556 | ABC-family proteins mediated transport | 5.871293e-01 | 0.231 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 5.891039e-01 | 0.230 |
| R-HSA-165159 | MTOR signalling | 5.891039e-01 | 0.230 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 5.891039e-01 | 0.230 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 5.891039e-01 | 0.230 |
| R-HSA-73928 | Depyrimidination | 5.891039e-01 | 0.230 |
| R-HSA-397014 | Muscle contraction | 5.912455e-01 | 0.228 |
| R-HSA-9710421 | Defective pyroptosis | 5.963598e-01 | 0.224 |
| R-HSA-5654743 | Signaling by FGFR4 | 5.963598e-01 | 0.224 |
| R-HSA-8854214 | TBC/RABGAPs | 5.963598e-01 | 0.224 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 5.968298e-01 | 0.224 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 5.968298e-01 | 0.224 |
| R-HSA-1483255 | PI Metabolism | 5.968298e-01 | 0.224 |
| R-HSA-162587 | HIV Life Cycle | 6.018983e-01 | 0.220 |
| R-HSA-9907900 | Proteasome assembly | 6.034880e-01 | 0.219 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 6.034880e-01 | 0.219 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 6.034880e-01 | 0.219 |
| R-HSA-5683826 | Surfactant metabolism | 6.034880e-01 | 0.219 |
| R-HSA-2172127 | DAP12 interactions | 6.034880e-01 | 0.219 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 6.063589e-01 | 0.217 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 6.104908e-01 | 0.214 |
| R-HSA-774815 | Nucleosome assembly | 6.104908e-01 | 0.214 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 6.104908e-01 | 0.214 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 6.104908e-01 | 0.214 |
| R-HSA-77286 | mitochondrial fatty acid beta-oxidation of saturated fatty acids | 6.104908e-01 | 0.214 |
| R-HSA-5654741 | Signaling by FGFR3 | 6.104908e-01 | 0.214 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 6.104908e-01 | 0.214 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 6.104908e-01 | 0.214 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 6.104908e-01 | 0.214 |
| R-HSA-3560782 | Diseases associated with glycosaminoglycan metabolism | 6.104908e-01 | 0.214 |
| R-HSA-418990 | Adherens junctions interactions | 6.112633e-01 | 0.214 |
| R-HSA-9006936 | Signaling by TGFB family members | 6.133487e-01 | 0.212 |
| R-HSA-5653656 | Vesicle-mediated transport | 6.144161e-01 | 0.212 |
| R-HSA-5696398 | Nucleotide Excision Repair | 6.157168e-01 | 0.211 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 6.157168e-01 | 0.211 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 6.173703e-01 | 0.209 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 6.173703e-01 | 0.209 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 6.173703e-01 | 0.209 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 6.173703e-01 | 0.209 |
| R-HSA-8951664 | Neddylation | 6.210441e-01 | 0.207 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 6.230111e-01 | 0.206 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 6.241288e-01 | 0.205 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 6.241288e-01 | 0.205 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 6.241288e-01 | 0.205 |
| R-HSA-2046104 | alpha-linolenic (omega3) and linoleic (omega6) acid metabolism | 6.241288e-01 | 0.205 |
| R-HSA-69239 | Synthesis of DNA | 6.249037e-01 | 0.204 |
| R-HSA-211000 | Gene Silencing by RNA | 6.249037e-01 | 0.204 |
| R-HSA-2408522 | Selenoamino acid metabolism | 6.282698e-01 | 0.202 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 6.294332e-01 | 0.201 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 6.294332e-01 | 0.201 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 6.294332e-01 | 0.201 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 6.294332e-01 | 0.201 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 6.307682e-01 | 0.200 |
| R-HSA-389356 | Co-stimulation by CD28 | 6.307682e-01 | 0.200 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 6.339202e-01 | 0.198 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 6.339202e-01 | 0.198 |
| R-HSA-73893 | DNA Damage Bypass | 6.372908e-01 | 0.196 |
| R-HSA-1638074 | Keratan sulfate/keratin metabolism | 6.372908e-01 | 0.196 |
| R-HSA-380108 | Chemokine receptors bind chemokines | 6.372908e-01 | 0.196 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 6.372908e-01 | 0.196 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 6.372908e-01 | 0.196 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 6.383648e-01 | 0.195 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 6.383648e-01 | 0.195 |
| R-HSA-8978868 | Fatty acid metabolism | 6.384820e-01 | 0.195 |
| R-HSA-5619102 | SLC transporter disorders | 6.391987e-01 | 0.194 |
| R-HSA-162906 | HIV Infection | 6.401384e-01 | 0.194 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 6.436986e-01 | 0.191 |
| R-HSA-912446 | Meiotic recombination | 6.499935e-01 | 0.187 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 6.514447e-01 | 0.186 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 6.534187e-01 | 0.185 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 6.561777e-01 | 0.183 |
| R-HSA-72187 | mRNA 3'-end processing | 6.561777e-01 | 0.183 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 6.561777e-01 | 0.183 |
| R-HSA-68949 | Orc1 removal from chromatin | 6.561777e-01 | 0.183 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 6.622529e-01 | 0.179 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 6.622529e-01 | 0.179 |
| R-HSA-1221632 | Meiotic synapsis | 6.622529e-01 | 0.179 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 6.622529e-01 | 0.179 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 6.641467e-01 | 0.178 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 6.682211e-01 | 0.175 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 6.682211e-01 | 0.175 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 6.682211e-01 | 0.175 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 6.682974e-01 | 0.175 |
| R-HSA-909733 | Interferon alpha/beta signaling | 6.682974e-01 | 0.175 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 6.724066e-01 | 0.172 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 6.724066e-01 | 0.172 |
| R-HSA-9753281 | Paracetamol ADME | 6.740843e-01 | 0.171 |
| R-HSA-1793185 | Chondroitin sulfate/dermatan sulfate metabolism | 6.740843e-01 | 0.171 |
| R-HSA-9007101 | Rab regulation of trafficking | 6.764746e-01 | 0.170 |
| R-HSA-2980736 | Peptide hormone metabolism | 6.764746e-01 | 0.170 |
| R-HSA-157118 | Signaling by NOTCH | 6.793172e-01 | 0.168 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 6.798442e-01 | 0.168 |
| R-HSA-5654736 | Signaling by FGFR1 | 6.798442e-01 | 0.168 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 6.798442e-01 | 0.168 |
| R-HSA-209776 | Metabolism of amine-derived hormones | 6.798442e-01 | 0.168 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 6.844876e-01 | 0.165 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 6.844876e-01 | 0.165 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 6.855026e-01 | 0.164 |
| R-HSA-68875 | Mitotic Prophase | 6.884330e-01 | 0.162 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 6.910614e-01 | 0.160 |
| R-HSA-6782135 | Dual incision in TC-NER | 6.910614e-01 | 0.160 |
| R-HSA-3371556 | Cellular response to heat stress | 6.923378e-01 | 0.160 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 6.962023e-01 | 0.157 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 6.962023e-01 | 0.157 |
| R-HSA-191859 | snRNP Assembly | 6.965223e-01 | 0.157 |
| R-HSA-194441 | Metabolism of non-coding RNA | 6.965223e-01 | 0.157 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 6.965223e-01 | 0.157 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 7.000267e-01 | 0.155 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 7.009741e-01 | 0.154 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 7.018869e-01 | 0.154 |
| R-HSA-1227986 | Signaling by ERBB2 | 7.018869e-01 | 0.154 |
| R-HSA-351202 | Metabolism of polyamines | 7.018869e-01 | 0.154 |
| R-HSA-162909 | Host Interactions of HIV factors | 7.038112e-01 | 0.153 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 7.071571e-01 | 0.150 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 7.071571e-01 | 0.150 |
| R-HSA-450294 | MAP kinase activation | 7.071571e-01 | 0.150 |
| R-HSA-421270 | Cell-cell junction organization | 7.100806e-01 | 0.149 |
| R-HSA-6784531 | tRNA processing in the nucleus | 7.123344e-01 | 0.147 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 7.123344e-01 | 0.147 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 7.123344e-01 | 0.147 |
| R-HSA-186797 | Signaling by PDGF | 7.123344e-01 | 0.147 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 7.123344e-01 | 0.147 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 7.123344e-01 | 0.147 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 7.124156e-01 | 0.147 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 7.174205e-01 | 0.144 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 7.221428e-01 | 0.141 |
| R-HSA-913531 | Interferon Signaling | 7.244714e-01 | 0.140 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 7.292040e-01 | 0.137 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 7.321474e-01 | 0.135 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 7.321474e-01 | 0.135 |
| R-HSA-1474165 | Reproduction | 7.326774e-01 | 0.135 |
| R-HSA-5693606 | DNA Double Strand Break Response | 7.368844e-01 | 0.133 |
| R-HSA-196807 | Nicotinate metabolism | 7.368844e-01 | 0.133 |
| R-HSA-9909396 | Circadian clock | 7.395109e-01 | 0.131 |
| R-HSA-6798695 | Neutrophil degranulation | 7.467212e-01 | 0.127 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 7.506002e-01 | 0.125 |
| R-HSA-9840310 | Glycosphingolipid catabolism | 7.506002e-01 | 0.125 |
| R-HSA-448424 | Interleukin-17 signaling | 7.506002e-01 | 0.125 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 7.506002e-01 | 0.125 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 7.550119e-01 | 0.122 |
| R-HSA-8978934 | Metabolism of cofactors | 7.550119e-01 | 0.122 |
| R-HSA-189445 | Metabolism of porphyrins | 7.550119e-01 | 0.122 |
| R-HSA-376176 | Signaling by ROBO receptors | 7.554360e-01 | 0.122 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 7.593458e-01 | 0.120 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 7.593458e-01 | 0.120 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 7.593458e-01 | 0.120 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 7.593458e-01 | 0.120 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 7.636034e-01 | 0.117 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 7.636034e-01 | 0.117 |
| R-HSA-9749641 | Aspirin ADME | 7.636034e-01 | 0.117 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 7.653730e-01 | 0.116 |
| R-HSA-1226099 | Signaling by FGFR in disease | 7.677859e-01 | 0.115 |
| R-HSA-9013694 | Signaling by NOTCH4 | 7.677859e-01 | 0.115 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 7.718946e-01 | 0.112 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 7.718946e-01 | 0.112 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 7.759309e-01 | 0.110 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 7.774505e-01 | 0.109 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 7.803839e-01 | 0.108 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 7.811406e-01 | 0.107 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 7.832834e-01 | 0.106 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 7.835849e-01 | 0.106 |
| R-HSA-73864 | RNA Polymerase I Transcription | 7.837912e-01 | 0.106 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 7.876177e-01 | 0.104 |
| R-HSA-5579029 | Metabolic disorders of biological oxidation enzymes | 7.876177e-01 | 0.104 |
| R-HSA-6806834 | Signaling by MET | 7.913766e-01 | 0.102 |
| R-HSA-9833482 | PKR-mediated signaling | 7.913766e-01 | 0.102 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 7.945488e-01 | 0.100 |
| R-HSA-69242 | S Phase | 7.945488e-01 | 0.100 |
| R-HSA-166520 | Signaling by NTRKs | 7.945488e-01 | 0.100 |
| R-HSA-9758941 | Gastrulation | 7.972833e-01 | 0.098 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 7.986969e-01 | 0.098 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 8.026561e-01 | 0.095 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 8.052950e-01 | 0.094 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 8.052950e-01 | 0.094 |
| R-HSA-2142753 | Arachidonate metabolism | 8.052950e-01 | 0.094 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 8.057612e-01 | 0.094 |
| R-HSA-73894 | DNA Repair | 8.061784e-01 | 0.094 |
| R-HSA-69306 | DNA Replication | 8.079025e-01 | 0.093 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 8.104790e-01 | 0.091 |
| R-HSA-72766 | Translation | 8.119425e-01 | 0.090 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 8.125784e-01 | 0.090 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 8.130247e-01 | 0.090 |
| R-HSA-1989781 | PPARA activates gene expression | 8.130247e-01 | 0.090 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 8.176158e-01 | 0.087 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 8.180250e-01 | 0.087 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 8.191571e-01 | 0.087 |
| R-HSA-70268 | Pyruvate metabolism | 8.191571e-01 | 0.087 |
| R-HSA-156902 | Peptide chain elongation | 8.223597e-01 | 0.085 |
| R-HSA-9663891 | Selective autophagy | 8.223597e-01 | 0.085 |
| R-HSA-877300 | Interferon gamma signaling | 8.229055e-01 | 0.085 |
| R-HSA-72312 | rRNA processing | 8.258887e-01 | 0.083 |
| R-HSA-3247509 | Chromatin modifying enzymes | 8.299040e-01 | 0.081 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 8.346145e-01 | 0.079 |
| R-HSA-391251 | Protein folding | 8.375443e-01 | 0.077 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 8.375443e-01 | 0.077 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 8.375443e-01 | 0.077 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 8.404223e-01 | 0.076 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 8.404223e-01 | 0.076 |
| R-HSA-9837999 | Mitochondrial protein degradation | 8.432495e-01 | 0.074 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 8.460268e-01 | 0.073 |
| R-HSA-77289 | Mitochondrial Fatty Acid Beta-Oxidation | 8.460268e-01 | 0.073 |
| R-HSA-72764 | Eukaryotic Translation Termination | 8.487550e-01 | 0.071 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 8.487550e-01 | 0.071 |
| R-HSA-72306 | tRNA processing | 8.497991e-01 | 0.071 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 8.514351e-01 | 0.070 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 8.514351e-01 | 0.070 |
| R-HSA-418555 | G alpha (s) signalling events | 8.518642e-01 | 0.070 |
| R-HSA-5689880 | Ub-specific processing proteases | 8.559172e-01 | 0.068 |
| R-HSA-1280218 | Adaptive Immune System | 8.564510e-01 | 0.067 |
| R-HSA-4839726 | Chromatin organization | 8.575636e-01 | 0.067 |
| R-HSA-3214847 | HATs acetylate histones | 8.591946e-01 | 0.066 |
| R-HSA-2408557 | Selenocysteine synthesis | 8.641419e-01 | 0.063 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 8.641419e-01 | 0.063 |
| R-HSA-168255 | Influenza Infection | 8.674774e-01 | 0.062 |
| R-HSA-112316 | Neuronal System | 8.677280e-01 | 0.062 |
| R-HSA-192823 | Viral mRNA Translation | 8.689160e-01 | 0.061 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 8.712399e-01 | 0.060 |
| R-HSA-111885 | Opioid Signalling | 8.712399e-01 | 0.060 |
| R-HSA-1474244 | Extracellular matrix organization | 8.712948e-01 | 0.060 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 8.779684e-01 | 0.057 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 8.801324e-01 | 0.055 |
| R-HSA-168898 | Toll-like Receptor Cascades | 8.880874e-01 | 0.052 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 8.903921e-01 | 0.050 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 8.903921e-01 | 0.050 |
| R-HSA-1483249 | Inositol phosphate metabolism | 8.903921e-01 | 0.050 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 8.979659e-01 | 0.047 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 8.997765e-01 | 0.046 |
| R-HSA-5668914 | Diseases of metabolism | 9.011035e-01 | 0.045 |
| R-HSA-373760 | L1CAM interactions | 9.015550e-01 | 0.045 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 9.015554e-01 | 0.045 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 9.043362e-01 | 0.044 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 9.099866e-01 | 0.041 |
| R-HSA-1660662 | Glycosphingolipid metabolism | 9.131542e-01 | 0.039 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 9.131542e-01 | 0.039 |
| R-HSA-1483257 | Phospholipid metabolism | 9.193482e-01 | 0.037 |
| R-HSA-8956319 | Nucleotide catabolism | 9.233909e-01 | 0.035 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 9.286910e-01 | 0.032 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.372374e-01 | 0.028 |
| R-HSA-15869 | Metabolism of nucleotides | 9.425532e-01 | 0.026 |
| R-HSA-112315 | Transmission across Chemical Synapses | 9.438366e-01 | 0.025 |
| R-HSA-388396 | GPCR downstream signalling | 9.458690e-01 | 0.024 |
| R-HSA-168256 | Immune System | 9.459687e-01 | 0.024 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 9.474309e-01 | 0.023 |
| R-HSA-9824446 | Viral Infection Pathways | 9.499597e-01 | 0.022 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 9.501863e-01 | 0.022 |
| R-HSA-9679191 | Potential therapeutics for SARS | 9.501863e-01 | 0.022 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 9.536376e-01 | 0.021 |
| R-HSA-5688426 | Deubiquitination | 9.567078e-01 | 0.019 |
| R-HSA-9711097 | Cellular response to starvation | 9.568505e-01 | 0.019 |
| R-HSA-416476 | G alpha (q) signalling events | 9.621868e-01 | 0.017 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 9.632914e-01 | 0.016 |
| R-HSA-9711123 | Cellular response to chemical stress | 9.644029e-01 | 0.016 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 9.670844e-01 | 0.015 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.675288e-01 | 0.014 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 9.682072e-01 | 0.014 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 9.687736e-01 | 0.014 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 9.694119e-01 | 0.013 |
| R-HSA-611105 | Respiratory electron transport | 9.704133e-01 | 0.013 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.706393e-01 | 0.013 |
| R-HSA-2559583 | Cellular Senescence | 9.714584e-01 | 0.013 |
| R-HSA-3781865 | Diseases of glycosylation | 9.734396e-01 | 0.012 |
| R-HSA-375276 | Peptide ligand-binding receptors | 9.743782e-01 | 0.011 |
| R-HSA-372790 | Signaling by GPCR | 9.756123e-01 | 0.011 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 9.774104e-01 | 0.010 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.788073e-01 | 0.009 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.796751e-01 | 0.009 |
| R-HSA-428157 | Sphingolipid metabolism | 9.804403e-01 | 0.009 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 9.811322e-01 | 0.008 |
| R-HSA-1643685 | Disease | 9.822918e-01 | 0.008 |
| R-HSA-168249 | Innate Immune System | 9.836943e-01 | 0.007 |
| R-HSA-8957322 | Metabolism of steroids | 9.849418e-01 | 0.007 |
| R-HSA-9748784 | Drug ADME | 9.858577e-01 | 0.006 |
| R-HSA-8953897 | Cellular responses to stimuli | 9.876136e-01 | 0.005 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.884592e-01 | 0.005 |
| R-HSA-109582 | Hemostasis | 9.896288e-01 | 0.005 |
| R-HSA-8939211 | ESR-mediated signaling | 9.899613e-01 | 0.004 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.899613e-01 | 0.004 |
| R-HSA-597592 | Post-translational protein modification | 9.944213e-01 | 0.002 |
| R-HSA-2262752 | Cellular responses to stress | 9.956435e-01 | 0.002 |
| R-HSA-418594 | G alpha (i) signalling events | 9.960286e-01 | 0.002 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.968833e-01 | 0.001 |
| R-HSA-392499 | Metabolism of proteins | 9.981836e-01 | 0.001 |
| R-HSA-500792 | GPCR ligand binding | 9.987949e-01 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 9.992608e-01 | 0.000 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.993853e-01 | 0.000 |
| R-HSA-211859 | Biological oxidations | 9.994074e-01 | 0.000 |
| R-HSA-5663205 | Infectious disease | 9.995713e-01 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 9.997232e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999997e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
TBK1 |
0.832 | 0.407 | 1 | 0.435 |
IKKE |
0.831 | 0.434 | 1 | 0.462 |
COT |
0.829 | 0.089 | 2 | 0.885 |
MST4 |
0.823 | 0.208 | 2 | 0.901 |
RAF1 |
0.820 | 0.329 | 1 | 0.381 |
CLK3 |
0.819 | 0.074 | 1 | 0.206 |
DSTYK |
0.819 | 0.141 | 2 | 0.920 |
MTOR |
0.817 | 0.104 | 1 | 0.307 |
BCKDK |
0.817 | 0.257 | -1 | 0.849 |
PKCD |
0.816 | 0.146 | 2 | 0.857 |
IKKB |
0.816 | 0.153 | -2 | 0.779 |
ULK2 |
0.814 | 0.033 | 2 | 0.814 |
PDHK1 |
0.813 | 0.290 | 1 | 0.382 |
PKN3 |
0.813 | 0.069 | -3 | 0.834 |
WNK1 |
0.813 | 0.128 | -2 | 0.884 |
PRKD1 |
0.813 | 0.088 | -3 | 0.834 |
MARK4 |
0.812 | 0.104 | 4 | 0.913 |
PRKD2 |
0.811 | 0.096 | -3 | 0.804 |
GCN2 |
0.811 | -0.068 | 2 | 0.829 |
PIM3 |
0.811 | 0.016 | -3 | 0.852 |
PKN2 |
0.810 | 0.108 | -3 | 0.852 |
NLK |
0.809 | 0.029 | 1 | 0.255 |
NEK6 |
0.809 | 0.033 | -2 | 0.879 |
CDC7 |
0.808 | -0.083 | 1 | 0.218 |
PDHK4 |
0.808 | 0.130 | 1 | 0.334 |
NDR2 |
0.807 | 0.012 | -3 | 0.862 |
DNAPK |
0.807 | 0.171 | 1 | 0.392 |
NUAK2 |
0.807 | 0.049 | -3 | 0.853 |
NEK7 |
0.806 | 0.037 | -3 | 0.811 |
PRPK |
0.806 | -0.037 | -1 | 0.831 |
IKKA |
0.806 | 0.107 | -2 | 0.768 |
CAMK2D |
0.806 | 0.102 | -3 | 0.850 |
RSK2 |
0.806 | 0.050 | -3 | 0.793 |
CAMK1B |
0.806 | 0.020 | -3 | 0.866 |
MAPKAPK3 |
0.805 | 0.057 | -3 | 0.810 |
NDR1 |
0.805 | 0.028 | -3 | 0.860 |
AMPKA1 |
0.805 | 0.058 | -3 | 0.872 |
NIK |
0.805 | 0.102 | -3 | 0.887 |
MOS |
0.805 | -0.062 | 1 | 0.222 |
TSSK1 |
0.804 | 0.095 | -3 | 0.890 |
SRPK1 |
0.804 | 0.047 | -3 | 0.758 |
CAMK2G |
0.804 | 0.009 | 2 | 0.847 |
MAPKAPK2 |
0.804 | 0.047 | -3 | 0.771 |
CDKL1 |
0.804 | 0.025 | -3 | 0.802 |
LATS2 |
0.804 | 0.049 | -5 | 0.757 |
PIM1 |
0.804 | 0.050 | -3 | 0.805 |
WNK3 |
0.803 | 0.092 | 1 | 0.325 |
RSK3 |
0.803 | 0.044 | -3 | 0.785 |
TGFBR2 |
0.803 | 0.039 | -2 | 0.812 |
YSK4 |
0.802 | 0.253 | 1 | 0.371 |
ULK1 |
0.802 | -0.017 | -3 | 0.793 |
PKCA |
0.802 | 0.137 | 2 | 0.812 |
ERK5 |
0.802 | -0.043 | 1 | 0.223 |
BMPR2 |
0.802 | 0.002 | -2 | 0.906 |
NEK9 |
0.802 | 0.075 | 2 | 0.871 |
ATR |
0.801 | -0.044 | 1 | 0.256 |
AMPKA2 |
0.801 | 0.053 | -3 | 0.849 |
QSK |
0.801 | 0.098 | 4 | 0.895 |
SRPK2 |
0.801 | 0.060 | -3 | 0.689 |
P90RSK |
0.801 | 0.033 | -3 | 0.790 |
MLK1 |
0.801 | 0.017 | 2 | 0.868 |
MNK2 |
0.801 | 0.078 | -2 | 0.811 |
NIM1 |
0.801 | 0.035 | 3 | 0.810 |
SKMLCK |
0.800 | 0.021 | -2 | 0.865 |
PKCB |
0.800 | 0.082 | 2 | 0.818 |
PHKG1 |
0.800 | 0.076 | -3 | 0.849 |
NEK2 |
0.800 | 0.168 | 2 | 0.861 |
FAM20C |
0.800 | 0.080 | 2 | 0.694 |
LATS1 |
0.800 | 0.131 | -3 | 0.881 |
HUNK |
0.800 | -0.018 | 2 | 0.782 |
CDKL5 |
0.799 | 0.005 | -3 | 0.796 |
SIK |
0.799 | 0.083 | -3 | 0.787 |
KIS |
0.799 | -0.032 | 1 | 0.176 |
CHAK2 |
0.799 | 0.012 | -1 | 0.851 |
PKACG |
0.799 | 0.062 | -2 | 0.746 |
HIPK4 |
0.799 | -0.012 | 1 | 0.211 |
PKCG |
0.799 | 0.102 | 2 | 0.814 |
TSSK2 |
0.798 | 0.051 | -5 | 0.848 |
CAMK2B |
0.798 | 0.079 | 2 | 0.814 |
NUAK1 |
0.797 | 0.026 | -3 | 0.823 |
P70S6KB |
0.797 | 0.040 | -3 | 0.820 |
MELK |
0.797 | 0.030 | -3 | 0.836 |
MARK3 |
0.797 | 0.100 | 4 | 0.871 |
CDK8 |
0.796 | -0.052 | 1 | 0.167 |
CAMLCK |
0.796 | 0.015 | -2 | 0.867 |
QIK |
0.796 | 0.063 | -3 | 0.837 |
AURC |
0.796 | 0.063 | -2 | 0.669 |
RIPK3 |
0.796 | -0.040 | 3 | 0.740 |
PRKD3 |
0.796 | 0.062 | -3 | 0.760 |
CDK5 |
0.795 | -0.004 | 1 | 0.165 |
ANKRD3 |
0.795 | 0.066 | 1 | 0.298 |
MARK2 |
0.795 | 0.100 | 4 | 0.845 |
PHKG2 |
0.795 | 0.132 | -3 | 0.824 |
PKCH |
0.795 | 0.087 | 2 | 0.797 |
MLK3 |
0.795 | 0.029 | 2 | 0.821 |
PAK6 |
0.795 | 0.089 | -2 | 0.736 |
JNK2 |
0.795 | -0.008 | 1 | 0.178 |
PKR |
0.794 | 0.093 | 1 | 0.269 |
ATM |
0.794 | -0.026 | 1 | 0.240 |
IRE1 |
0.794 | -0.020 | 1 | 0.232 |
CDK19 |
0.794 | -0.048 | 1 | 0.158 |
ICK |
0.794 | 0.009 | -3 | 0.835 |
DAPK2 |
0.793 | -0.012 | -3 | 0.868 |
GRK1 |
0.793 | 0.016 | -2 | 0.788 |
CDK1 |
0.793 | -0.020 | 1 | 0.147 |
PAK1 |
0.793 | 0.032 | -2 | 0.794 |
PAK3 |
0.793 | 0.031 | -2 | 0.799 |
MLK2 |
0.793 | -0.025 | 2 | 0.854 |
IRE2 |
0.793 | 0.009 | 2 | 0.811 |
CLK1 |
0.793 | 0.058 | -3 | 0.768 |
CAMK2A |
0.792 | 0.062 | 2 | 0.831 |
PKCZ |
0.792 | 0.045 | 2 | 0.840 |
SGK3 |
0.792 | 0.087 | -3 | 0.788 |
BRSK1 |
0.792 | 0.043 | -3 | 0.817 |
MNK1 |
0.791 | 0.055 | -2 | 0.817 |
PLK1 |
0.791 | 0.029 | -2 | 0.835 |
CDK18 |
0.791 | -0.032 | 1 | 0.139 |
CDK13 |
0.791 | -0.038 | 1 | 0.168 |
GRK6 |
0.791 | -0.024 | 1 | 0.253 |
MSK2 |
0.791 | 0.020 | -3 | 0.749 |
BRSK2 |
0.791 | 0.036 | -3 | 0.841 |
DLK |
0.791 | -0.022 | 1 | 0.274 |
PKACB |
0.791 | 0.067 | -2 | 0.684 |
MARK1 |
0.790 | 0.094 | 4 | 0.882 |
CDK3 |
0.790 | 0.003 | 1 | 0.127 |
RSK4 |
0.790 | 0.051 | -3 | 0.764 |
CAMK4 |
0.790 | -0.019 | -3 | 0.840 |
PKCT |
0.790 | 0.090 | 2 | 0.804 |
CDK7 |
0.790 | -0.056 | 1 | 0.171 |
TTBK2 |
0.789 | -0.006 | 2 | 0.723 |
CLK4 |
0.789 | 0.037 | -3 | 0.784 |
AURB |
0.789 | 0.070 | -2 | 0.671 |
SRPK3 |
0.789 | 0.053 | -3 | 0.723 |
P38G |
0.789 | -0.035 | 1 | 0.130 |
PLK4 |
0.789 | 0.065 | 2 | 0.624 |
CHAK1 |
0.788 | 0.030 | 2 | 0.800 |
RIPK1 |
0.788 | -0.080 | 1 | 0.253 |
GRK5 |
0.788 | -0.129 | -3 | 0.827 |
BMPR1B |
0.787 | -0.024 | 1 | 0.193 |
HIPK2 |
0.787 | -0.017 | 1 | 0.138 |
CDK17 |
0.787 | -0.045 | 1 | 0.125 |
MSK1 |
0.787 | 0.052 | -3 | 0.767 |
JNK3 |
0.787 | -0.031 | 1 | 0.172 |
DYRK2 |
0.787 | -0.042 | 1 | 0.171 |
CHK1 |
0.787 | 0.040 | -3 | 0.870 |
PKG2 |
0.787 | 0.059 | -2 | 0.680 |
GRK7 |
0.787 | 0.012 | 1 | 0.221 |
MLK4 |
0.787 | 0.002 | 2 | 0.792 |
KHS2 |
0.786 | 0.421 | 1 | 0.470 |
TAO3 |
0.786 | 0.175 | 1 | 0.319 |
MST3 |
0.786 | 0.172 | 2 | 0.880 |
ERK1 |
0.786 | -0.034 | 1 | 0.175 |
KHS1 |
0.786 | 0.446 | 1 | 0.466 |
TGFBR1 |
0.786 | -0.018 | -2 | 0.813 |
CDK12 |
0.786 | -0.036 | 1 | 0.165 |
GCK |
0.785 | 0.379 | 1 | 0.414 |
CLK2 |
0.785 | 0.049 | -3 | 0.777 |
MASTL |
0.785 | -0.119 | -2 | 0.842 |
MINK |
0.785 | 0.394 | 1 | 0.424 |
TLK2 |
0.785 | 0.049 | 1 | 0.309 |
AURA |
0.784 | 0.078 | -2 | 0.650 |
ALK4 |
0.784 | -0.024 | -2 | 0.841 |
P38B |
0.784 | -0.034 | 1 | 0.169 |
CDK2 |
0.784 | -0.023 | 1 | 0.175 |
AKT2 |
0.784 | 0.057 | -3 | 0.709 |
TNIK |
0.784 | 0.315 | 3 | 0.899 |
WNK4 |
0.783 | 0.073 | -2 | 0.876 |
PLK3 |
0.783 | 0.004 | 2 | 0.776 |
P38A |
0.783 | -0.037 | 1 | 0.188 |
DCAMKL1 |
0.783 | 0.029 | -3 | 0.821 |
HPK1 |
0.783 | 0.397 | 1 | 0.450 |
CDK9 |
0.783 | -0.048 | 1 | 0.176 |
MEKK1 |
0.783 | 0.083 | 1 | 0.301 |
HGK |
0.783 | 0.287 | 3 | 0.895 |
AKT1 |
0.783 | 0.078 | -3 | 0.736 |
PRKX |
0.783 | 0.060 | -3 | 0.721 |
CDK16 |
0.782 | -0.022 | 1 | 0.129 |
ZAK |
0.782 | 0.052 | 1 | 0.296 |
HIPK1 |
0.782 | -0.016 | 1 | 0.175 |
ERK2 |
0.781 | -0.047 | 1 | 0.183 |
PAK2 |
0.781 | 0.012 | -2 | 0.782 |
PKCI |
0.781 | 0.082 | 2 | 0.823 |
PIM2 |
0.781 | 0.032 | -3 | 0.768 |
SSTK |
0.781 | 0.057 | 4 | 0.880 |
SMG1 |
0.781 | -0.052 | 1 | 0.258 |
MYLK4 |
0.780 | 0.017 | -2 | 0.783 |
MAPKAPK5 |
0.780 | -0.017 | -3 | 0.731 |
BRAF |
0.780 | 0.051 | -4 | 0.819 |
CAMK1G |
0.780 | -0.012 | -3 | 0.776 |
GRK4 |
0.779 | -0.087 | -2 | 0.825 |
CDK10 |
0.779 | -0.003 | 1 | 0.155 |
MEK1 |
0.779 | -0.040 | 2 | 0.838 |
HRI |
0.779 | -0.003 | -2 | 0.871 |
MST2 |
0.778 | 0.257 | 1 | 0.380 |
IRAK4 |
0.778 | -0.005 | 1 | 0.253 |
NEK5 |
0.778 | 0.050 | 1 | 0.283 |
MEKK2 |
0.778 | 0.072 | 2 | 0.834 |
SNRK |
0.778 | -0.045 | 2 | 0.697 |
PKACA |
0.778 | 0.068 | -2 | 0.636 |
ALK2 |
0.778 | -0.023 | -2 | 0.817 |
TAO2 |
0.777 | 0.148 | 2 | 0.896 |
LOK |
0.777 | 0.206 | -2 | 0.805 |
ACVR2A |
0.777 | -0.049 | -2 | 0.814 |
NEK4 |
0.777 | 0.236 | 1 | 0.372 |
TLK1 |
0.777 | 0.044 | -2 | 0.837 |
PKN1 |
0.777 | 0.060 | -3 | 0.745 |
ACVR2B |
0.776 | -0.054 | -2 | 0.820 |
CDK14 |
0.776 | -0.033 | 1 | 0.170 |
DCAMKL2 |
0.776 | 0.013 | -3 | 0.840 |
PAK5 |
0.776 | 0.053 | -2 | 0.672 |
VRK2 |
0.776 | -0.128 | 1 | 0.252 |
PERK |
0.776 | -0.031 | -2 | 0.855 |
HIPK3 |
0.776 | -0.021 | 1 | 0.200 |
P38D |
0.776 | -0.036 | 1 | 0.141 |
MEKK3 |
0.775 | 0.025 | 1 | 0.309 |
PKCE |
0.775 | 0.085 | 2 | 0.804 |
MST1 |
0.775 | 0.292 | 1 | 0.396 |
DRAK1 |
0.775 | -0.099 | 1 | 0.207 |
DYRK1A |
0.774 | -0.027 | 1 | 0.194 |
P70S6K |
0.774 | 0.033 | -3 | 0.729 |
MEK5 |
0.773 | -0.019 | 2 | 0.843 |
SLK |
0.773 | 0.178 | -2 | 0.746 |
DYRK4 |
0.772 | -0.041 | 1 | 0.144 |
DYRK1B |
0.772 | -0.043 | 1 | 0.146 |
CAMK1D |
0.772 | 0.026 | -3 | 0.722 |
CDK4 |
0.771 | -0.018 | 1 | 0.163 |
BMPR1A |
0.771 | -0.037 | 1 | 0.182 |
PAK4 |
0.771 | 0.042 | -2 | 0.680 |
NEK8 |
0.770 | 0.021 | 2 | 0.864 |
CDK6 |
0.770 | -0.014 | 1 | 0.162 |
ERK7 |
0.770 | 0.035 | 2 | 0.663 |
NEK11 |
0.770 | 0.107 | 1 | 0.344 |
PRP4 |
0.770 | -0.014 | -3 | 0.769 |
SMMLCK |
0.769 | 0.010 | -3 | 0.823 |
MRCKB |
0.769 | 0.105 | -3 | 0.766 |
YSK1 |
0.768 | 0.145 | 2 | 0.864 |
TAK1 |
0.768 | 0.212 | 1 | 0.361 |
PINK1 |
0.768 | -0.109 | 1 | 0.217 |
DYRK3 |
0.768 | -0.025 | 1 | 0.175 |
MRCKA |
0.768 | 0.104 | -3 | 0.789 |
MAP3K15 |
0.768 | 0.091 | 1 | 0.308 |
AKT3 |
0.767 | 0.059 | -3 | 0.649 |
CAMKK1 |
0.767 | 0.009 | -2 | 0.804 |
MEKK6 |
0.767 | 0.076 | 1 | 0.308 |
ROCK2 |
0.767 | 0.108 | -3 | 0.817 |
MPSK1 |
0.766 | -0.051 | 1 | 0.209 |
NEK1 |
0.766 | 0.112 | 1 | 0.298 |
CHK2 |
0.765 | 0.059 | -3 | 0.663 |
EEF2K |
0.765 | 0.067 | 3 | 0.886 |
TTBK1 |
0.765 | -0.020 | 2 | 0.639 |
PDK1 |
0.764 | 0.015 | 1 | 0.286 |
LKB1 |
0.764 | 0.004 | -3 | 0.826 |
CAMK1A |
0.764 | 0.035 | -3 | 0.686 |
SGK1 |
0.764 | 0.060 | -3 | 0.636 |
CAMKK2 |
0.763 | 0.004 | -2 | 0.802 |
DAPK3 |
0.763 | 0.008 | -3 | 0.821 |
JNK1 |
0.762 | -0.052 | 1 | 0.155 |
GRK2 |
0.761 | -0.106 | -2 | 0.710 |
CK2A2 |
0.760 | -0.037 | 1 | 0.154 |
GAK |
0.760 | -0.057 | 1 | 0.229 |
PASK |
0.759 | -0.063 | -3 | 0.847 |
MAK |
0.759 | 0.006 | -2 | 0.721 |
TAO1 |
0.759 | 0.161 | 1 | 0.341 |
LRRK2 |
0.759 | 0.043 | 2 | 0.884 |
IRAK1 |
0.759 | -0.073 | -1 | 0.745 |
CK1G1 |
0.757 | 0.024 | -3 | 0.479 |
BUB1 |
0.757 | 0.023 | -5 | 0.810 |
ROCK1 |
0.757 | 0.102 | -3 | 0.786 |
NEK3 |
0.756 | 0.041 | 1 | 0.297 |
GSK3A |
0.755 | -0.018 | 4 | 0.460 |
MYO3A |
0.754 | 0.206 | 1 | 0.366 |
RIPK2 |
0.754 | -0.046 | 1 | 0.306 |
MOK |
0.754 | -0.025 | 1 | 0.163 |
GSK3B |
0.753 | -0.020 | 4 | 0.450 |
MYO3B |
0.753 | 0.135 | 2 | 0.881 |
DAPK1 |
0.752 | -0.014 | -3 | 0.792 |
PLK2 |
0.751 | -0.010 | -3 | 0.772 |
PKG1 |
0.751 | 0.035 | -2 | 0.601 |
DMPK1 |
0.751 | 0.058 | -3 | 0.789 |
PBK |
0.750 | -0.053 | 1 | 0.213 |
STK33 |
0.750 | -0.068 | 2 | 0.624 |
MEK2 |
0.750 | -0.012 | 2 | 0.813 |
PDHK3_TYR |
0.750 | 0.065 | 4 | 0.909 |
VRK1 |
0.750 | -0.105 | 2 | 0.846 |
OSR1 |
0.750 | 0.046 | 2 | 0.822 |
CK2A1 |
0.749 | -0.052 | 1 | 0.151 |
SBK |
0.748 | 0.019 | -3 | 0.603 |
HASPIN |
0.748 | 0.001 | -1 | 0.704 |
CRIK |
0.747 | 0.051 | -3 | 0.730 |
CK1E |
0.747 | -0.083 | -3 | 0.471 |
TTK |
0.744 | 0.029 | -2 | 0.837 |
NEK10_TYR |
0.744 | 0.156 | 1 | 0.330 |
ASK1 |
0.743 | 0.038 | 1 | 0.300 |
GRK3 |
0.742 | -0.110 | -2 | 0.659 |
TESK1_TYR |
0.742 | -0.033 | 3 | 0.902 |
BIKE |
0.742 | -0.046 | 1 | 0.185 |
TYK2 |
0.741 | 0.151 | 1 | 0.318 |
RET |
0.741 | 0.103 | 1 | 0.300 |
LIMK2_TYR |
0.739 | -0.003 | -3 | 0.899 |
PDHK4_TYR |
0.739 | -0.025 | 2 | 0.888 |
CK1D |
0.739 | -0.065 | -3 | 0.418 |
MAP2K7_TYR |
0.738 | -0.024 | 2 | 0.873 |
CK1A2 |
0.737 | -0.064 | -3 | 0.417 |
PINK1_TYR |
0.737 | -0.089 | 1 | 0.239 |
JAK1 |
0.736 | 0.163 | 1 | 0.346 |
JAK2 |
0.736 | 0.097 | 1 | 0.315 |
MAP2K4_TYR |
0.736 | -0.087 | -1 | 0.857 |
MST1R |
0.735 | 0.046 | 3 | 0.810 |
ROS1 |
0.735 | 0.076 | 3 | 0.785 |
BMPR2_TYR |
0.735 | -0.011 | -1 | 0.856 |
EPHA6 |
0.734 | -0.010 | -1 | 0.854 |
AAK1 |
0.734 | -0.026 | 1 | 0.151 |
MAP2K6_TYR |
0.734 | -0.085 | -1 | 0.863 |
PKMYT1_TYR |
0.733 | -0.118 | 3 | 0.862 |
TNNI3K_TYR |
0.733 | 0.042 | 1 | 0.253 |
STLK3 |
0.732 | 0.027 | 1 | 0.314 |
CSF1R |
0.731 | 0.024 | 3 | 0.786 |
TYRO3 |
0.730 | -0.037 | 3 | 0.816 |
PDHK1_TYR |
0.730 | -0.095 | -1 | 0.865 |
LIMK1_TYR |
0.730 | -0.093 | 2 | 0.883 |
JAK3 |
0.729 | -0.039 | 1 | 0.254 |
EPHB4 |
0.728 | -0.050 | -1 | 0.837 |
FLT3 |
0.728 | 0.017 | 3 | 0.811 |
DDR1 |
0.727 | -0.077 | 4 | 0.844 |
PDGFRB |
0.727 | -0.036 | 3 | 0.811 |
INSRR |
0.727 | 0.005 | 3 | 0.755 |
ALPHAK3 |
0.725 | -0.083 | -1 | 0.744 |
ABL2 |
0.725 | -0.035 | -1 | 0.780 |
TNK1 |
0.725 | 0.003 | 3 | 0.791 |
PDGFRA |
0.722 | -0.011 | 3 | 0.808 |
TXK |
0.722 | -0.076 | 1 | 0.200 |
FGFR2 |
0.721 | -0.067 | 3 | 0.792 |
KDR |
0.720 | -0.029 | 3 | 0.751 |
YES1 |
0.720 | -0.091 | -1 | 0.800 |
ABL1 |
0.720 | -0.057 | -1 | 0.770 |
FGFR1 |
0.719 | -0.061 | 3 | 0.768 |
FGR |
0.719 | -0.121 | 1 | 0.238 |
EPHB1 |
0.719 | -0.080 | 1 | 0.248 |
LCK |
0.718 | -0.047 | -1 | 0.781 |
HCK |
0.718 | -0.071 | -1 | 0.782 |
TNK2 |
0.718 | -0.079 | 3 | 0.743 |
KIT |
0.718 | -0.051 | 3 | 0.786 |
EPHB3 |
0.717 | -0.079 | -1 | 0.824 |
EPHA4 |
0.717 | -0.070 | 2 | 0.770 |
YANK3 |
0.716 | -0.060 | 2 | 0.406 |
AXL |
0.716 | -0.067 | 3 | 0.766 |
ALK |
0.716 | -0.019 | 3 | 0.726 |
EPHB2 |
0.716 | -0.071 | -1 | 0.815 |
FER |
0.716 | -0.142 | 1 | 0.241 |
ITK |
0.716 | -0.101 | -1 | 0.763 |
DDR2 |
0.715 | -0.032 | 3 | 0.733 |
BLK |
0.714 | -0.069 | -1 | 0.793 |
TEC |
0.714 | -0.048 | -1 | 0.708 |
SRMS |
0.714 | -0.116 | 1 | 0.241 |
BTK |
0.713 | -0.066 | -1 | 0.726 |
INSR |
0.713 | -0.051 | 3 | 0.732 |
LTK |
0.713 | -0.050 | 3 | 0.738 |
WEE1_TYR |
0.713 | -0.051 | -1 | 0.720 |
TEK |
0.713 | -0.079 | 3 | 0.740 |
NTRK1 |
0.712 | -0.071 | -1 | 0.808 |
MERTK |
0.712 | -0.089 | 3 | 0.763 |
FRK |
0.712 | -0.033 | -1 | 0.800 |
NTRK2 |
0.711 | -0.077 | 3 | 0.750 |
EPHA1 |
0.711 | -0.037 | 3 | 0.750 |
EPHA7 |
0.711 | -0.061 | 2 | 0.778 |
ERBB2 |
0.711 | -0.059 | 1 | 0.276 |
BMX |
0.709 | -0.083 | -1 | 0.682 |
MET |
0.709 | -0.106 | 3 | 0.776 |
FGFR3 |
0.709 | -0.075 | 3 | 0.763 |
EGFR |
0.708 | -0.061 | 1 | 0.212 |
FLT1 |
0.708 | -0.086 | -1 | 0.815 |
FLT4 |
0.708 | -0.083 | 3 | 0.740 |
EPHA3 |
0.707 | -0.075 | 2 | 0.749 |
PTK6 |
0.706 | -0.109 | -1 | 0.684 |
FYN |
0.705 | -0.074 | -1 | 0.754 |
NTRK3 |
0.705 | -0.101 | -1 | 0.756 |
MUSK |
0.703 | -0.081 | 1 | 0.209 |
EPHA5 |
0.703 | -0.066 | 2 | 0.757 |
LYN |
0.701 | -0.088 | 3 | 0.718 |
EPHA8 |
0.699 | -0.088 | -1 | 0.793 |
FGFR4 |
0.697 | -0.054 | -1 | 0.738 |
PTK2B |
0.697 | -0.127 | -1 | 0.748 |
CK1A |
0.697 | -0.095 | -3 | 0.328 |
CSK |
0.697 | -0.088 | 2 | 0.777 |
MATK |
0.696 | -0.106 | -1 | 0.706 |
IGF1R |
0.694 | -0.071 | 3 | 0.673 |
SRC |
0.694 | -0.117 | -1 | 0.753 |
CK1G3 |
0.693 | -0.013 | -3 | 0.280 |
PTK2 |
0.692 | -0.067 | -1 | 0.781 |
ERBB4 |
0.691 | -0.076 | 1 | 0.210 |
EPHA2 |
0.690 | -0.083 | -1 | 0.761 |
SYK |
0.690 | -0.077 | -1 | 0.745 |
YANK2 |
0.683 | -0.074 | 2 | 0.427 |
ZAP70 |
0.673 | -0.083 | -1 | 0.673 |
FES |
0.670 | -0.138 | -1 | 0.658 |
CK1G2 |
0.659 | -0.074 | -3 | 0.384 |