Motif 840 (n=147)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NKT7 | RGPD3 | S1315 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| A6NKT7 | RGPD3 | S1322 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| A6NMY6 | ANXA2P2 | S127 | ochoa | Putative annexin A2-like protein (Annexin A2 pseudogene 2) (Lipocortin II pseudogene) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. {ECO:0000250}. |
| O14503 | BHLHE40 | S243 | psp | Class E basic helix-loop-helix protein 40 (bHLHe40) (Class B basic helix-loop-helix protein 2) (bHLHb2) (Differentially expressed in chondrocytes protein 1) (DEC1) (Enhancer-of-split and hairy-related protein 2) (SHARP-2) (Stimulated by retinoic acid gene 13 protein) | Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes (PubMed:12397359, PubMed:18411297). Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop) (PubMed:14672706). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2 (PubMed:15193144). Represses the activity of the circadian transcriptional activator: CLOCK-BMAL1|BMAL2 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes (PubMed:15560782). Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2 (PubMed:14672706). Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA and NR1H3/LXRA transactivation activity (PubMed:19786558). May be involved in the regulation of chondrocyte differentiation via the cAMP pathway (PubMed:19786558). Represses the transcription of NR0B2 and attentuates the transactivation of NR0B2 by the CLOCK-BMAL1 complex (PubMed:28797635). Drives the circadian rhythm of blood pressure through transcriptional repression of ATP1B1 in the cardiovascular system (PubMed:30012868). {ECO:0000269|PubMed:12397359, ECO:0000269|PubMed:14672706, ECO:0000269|PubMed:15193144, ECO:0000269|PubMed:15560782, ECO:0000269|PubMed:18411297, ECO:0000269|PubMed:19786558, ECO:0000269|PubMed:28797635, ECO:0000269|PubMed:30012868}. |
| O15014 | ZNF609 | S614 | ochoa | Zinc finger protein 609 | Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others. {ECO:0000250|UniProtKB:Q8BZ47}.; FUNCTION: [Isoform 2]: Involved in the regulation of myoblast proliferation during myogenesis. {ECO:0000269|PubMed:28344082}. |
| O15061 | SYNM | S904 | ochoa | Synemin (Desmuslin) | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}. |
| O15432 | SLC31A2 | S63 | ochoa | Protein SLC31A2 (Copper transporter 2) (hCTR2) (Solute carrier family 31 member 2) | Does not function as a copper(1+) importer in vivo (By similarity). However, in vitro functions as a low-affinity copper(1+) importer (PubMed:17617060, PubMed:17944601). Regulator of SLC31A1 which facilitates the cleavage of the SLC31A1 ecto-domain or which stabilizes the truncated form of SLC31A1 (Truncated CTR1 form), thereby drives the SLC31A1 truncated form-dependent endosomal copper export and modulates the copper and cisplatin accumulation via SLC31A1 (By similarity). {ECO:0000250|UniProtKB:Q9CPU9, ECO:0000269|PubMed:17617060, ECO:0000269|PubMed:17944601}. |
| O15516 | CLOCK | S408 | ochoa | Circadian locomoter output cycles protein kaput (hCLOCK) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 8) (bHLHe8) | Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Regulates the circadian expression of ICAM1, VCAM1, CCL2, THPO and MPL and also acts as an enhancer of the transactivation potential of NF-kappaB. Plays an important role in the homeostatic regulation of sleep. The CLOCK-BMAL1 heterodimer regulates the circadian expression of SERPINE1/PAI1, VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1, GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1, ATF4, MTA1, KLF10 and also genes implicated in glucose and lipid metabolism. Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors. The CLOCK-BMAL2 heterodimer activates the transcription of SERPINE1/PAI1 and BHLHE40/DEC1. The preferred binding motif for the CLOCK-BMAL1 heterodimer is 5'-CACGTGA-3', which contains a flanking adenine nucleotide at the 3-prime end of the canonical 6-nucleotide E-box sequence (PubMed:23229515). CLOCK specifically binds to the half-site 5'-CAC-3', while BMAL1 binds to the half-site 5'-GTGA-3' (PubMed:23229515). The CLOCK-BMAL1 heterodimer also recognizes the non-canonical E-box motifs 5'-AACGTGA-3' and 5'-CATGTGA-3' (PubMed:23229515). CLOCK has an intrinsic acetyltransferase activity, which enables circadian chromatin remodeling by acetylating histones and nonhistone proteins, including its own partner BMAL1. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) via the acetylation of multiple lysine residues located in its hinge region (PubMed:21980503). The acetyltransferase activity of CLOCK is as important as its transcription activity in circadian control. Acetylates metabolic enzymes IMPDH2 and NDUFA9 in a circadian manner. Facilitated by BMAL1, rhythmically interacts and acetylates argininosuccinate synthase 1 (ASS1) leading to enzymatic inhibition of ASS1 as well as the circadian oscillation of arginine biosynthesis and subsequent ureagenesis (PubMed:28985504). Drives the circadian rhythm of blood pressure through transcriptional activation of ATP1B1 (By similarity). {ECO:0000250|UniProtKB:O08785, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:18587630, ECO:0000269|PubMed:21659603, ECO:0000269|PubMed:21980503, ECO:0000269|PubMed:22284746, ECO:0000269|PubMed:23229515, ECO:0000269|PubMed:23785138, ECO:0000269|PubMed:24005054, ECO:0000269|PubMed:28985504}. |
| O43524 | FOXO3 | S626 | psp | Forkhead box protein O3 (AF6q21 protein) (Forkhead in rhabdomyosarcoma-like 1) | Transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy (PubMed:10102273, PubMed:16751106, PubMed:21329882, PubMed:30513302). Acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, such as GABARAP1L, MAP1LC3B and ATG12, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins (By similarity). Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (PubMed:10102273, PubMed:16751106). Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (PubMed:21329882). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription. Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Also acts as a key regulator of regulatory T-cells (Treg) differentiation by activating expression of FOXP3 (PubMed:30513302). {ECO:0000250|UniProtKB:Q9WVH4, ECO:0000269|PubMed:10102273, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:21329882, ECO:0000269|PubMed:23283301, ECO:0000269|PubMed:30513302}. |
| O43719 | HTATSF1 | S624 | ochoa | 17S U2 SnRNP complex component HTATSF1 (HIV Tat-specific factor 1) (Tat-SF1) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:30567737, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:30567737, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, HTATSF1 is required to stabilize the branchpoint-interacting stem loop (PubMed:34822310). HTATSF1 is displaced from the 17S U2 SnRNP complex before the stable addition of the 17S U2 SnRNP complex to the spliceosome, destabilizing the branchpoint-interacting stem loop and allowing to probe intron branch site sequences (PubMed:32494006, PubMed:34822310). Also acts as a regulator of transcriptional elongation, possibly by mediating the reciprocal stimulatory effect of splicing on transcriptional elongation (PubMed:10454543, PubMed:10913173, PubMed:11780068). Involved in double-strand break (DSB) repair via homologous recombination in S-phase by promoting the recruitment of TOPBP1 to DNA damage sites (PubMed:35597237). Mechanistically, HTATSF1 is (1) recruited to DNA damage sites in S-phase via interaction with poly-ADP-ribosylated RPA1 and (2) phosphorylated by CK2, promoting recruitment of TOPBP1, thereby facilitating RAD51 nucleofilaments formation and RPA displacement, followed by homologous recombination (PubMed:35597237). {ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10913173, ECO:0000269|PubMed:11780068, ECO:0000269|PubMed:30567737, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:34822310, ECO:0000269|PubMed:35597237}.; FUNCTION: (Microbial infection) In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus. {ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:11420046, ECO:0000269|PubMed:15905670, ECO:0000269|PubMed:8849451, ECO:0000269|PubMed:9765201}. |
| O60271 | SPAG9 | S493 | ochoa | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}. |
| O75157 | TSC22D2 | S46 | ochoa | TSC22 domain family protein 2 (TSC22-related-inducible leucine zipper protein 4) | Reduces the level of nuclear PKM isoform M2 which results in repression of cyclin CCND1 transcription and reduced cell growth. {ECO:0000269|PubMed:27573352}. |
| O75324 | SNN | S49 | ochoa | Stannin (AG8_1) | Plays a role in the toxic effects of organotins (PubMed:15269288). Plays a role in endosomal maturation (PubMed:27015288). {ECO:0000269|PubMed:15269288, ECO:0000269|PubMed:27015288}. |
| O75363 | BCAS1 | S386 | ochoa | Breast carcinoma-amplified sequence 1 (Amplified and overexpressed in breast cancer) (Novel amplified in breast cancer 1) | Required for myelination. {ECO:0000250|UniProtKB:Q80YN3}. |
| O75554 | WBP4 | S227 | ochoa | WW domain-binding protein 4 (WBP-4) (Formin-binding protein 21) (WW domain-containing-binding protein 4) | Involved in pre-mRNA splicing as a component of the spliceosome (PubMed:19592703, PubMed:28781166, PubMed:9724750). May play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex (PubMed:9724750). {ECO:0000269|PubMed:19592703, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:9724750}. |
| O94906 | PRPF6 | S263 | ochoa | Pre-mRNA-processing factor 6 (Androgen receptor N-terminal domain-transactivating protein 1) (ANT-1) (PRP6 homolog) (U5 snRNP-associated 102 kDa protein) (U5-102 kDa protein) | Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome (PubMed:20118938, PubMed:21549338, PubMed:28781166). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation. {ECO:0000269|PubMed:12039962, ECO:0000269|PubMed:20118938, ECO:0000269|PubMed:21549338, ECO:0000269|PubMed:28781166}. |
| P00374 | DHFR | S145 | psp | Dihydrofolate reductase (EC 1.5.1.3) | Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2. {ECO:0000269|PubMed:12096917, ECO:0000269|PubMed:21876188}. |
| P05023 | ATP1A1 | S216 | ochoa | Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-1) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (PubMed:29499166, PubMed:30388404). Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity). {ECO:0000250|UniProtKB:Q8VDN2, ECO:0000269|PubMed:29499166, ECO:0000269|PubMed:30388404}. |
| P06213 | INSR | S1221 | psp | Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta] | Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosine residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD; regulates the expression of gluconeogenic and lipogenic enzymes by controlling the activity of the winged helix or forkhead (FOX) class of transcription factors. Another pathway regulated by PI3K-AKT/PKB activation is mTORC1 signaling pathway which regulates cell growth and metabolism and integrates signals from insulin. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 thereby activating mTORC1 pathway. The Ras/RAF/MAP2K/MAPK pathway is mainly involved in mediating cell growth, survival and cellular differentiation of insulin. Phosphorylated IRS1 recruits GRB2/SOS complex, which triggers the activation of the Ras/RAF/MAP2K/MAPK pathway. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). Isoform Short has a higher affinity for IGFII binding. When present in a hybrid receptor with IGF1R, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin. In adipocytes, inhibits lipolysis (By similarity). {ECO:0000250|UniProtKB:P15208, ECO:0000269|PubMed:12138094, ECO:0000269|PubMed:16314505, ECO:0000269|PubMed:16831875, ECO:0000269|PubMed:8257688, ECO:0000269|PubMed:8276809, ECO:0000269|PubMed:8452530, ECO:0000269|PubMed:9428692}. |
| P06400 | RB1 | S350 | ochoa | Retinoblastoma-associated protein (p105-Rb) (p110-RB1) (pRb) (Rb) (pp110) | Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle (PubMed:10499802). The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes (PubMed:10499802). Both physically blocks E2Fs transactivating domain and recruits chromatin-modifying enzymes that actively repress transcription (PubMed:10499802). Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase (PubMed:10499802). RB1 also promotes the G0-G1 transition upon phosphorylation and activation by CDK3/cyclin-C (PubMed:15084261). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). {ECO:0000250|UniProtKB:P13405, ECO:0000250|UniProtKB:P33568, ECO:0000269|PubMed:10499802, ECO:0000269|PubMed:15084261}.; FUNCTION: (Microbial infection) In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity. {ECO:0000269|PubMed:1316611, ECO:0000269|PubMed:17974914, ECO:0000269|PubMed:18701596, ECO:0000269|PubMed:2839300, ECO:0000269|PubMed:8892909}. |
| P07355 | ANXA2 | S127 | ochoa | Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:22848640, PubMed:24808179). Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation (By similarity). Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis (By similarity). {ECO:0000250|UniProtKB:P07356, ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22848640, ECO:0000269|PubMed:24808179}.; FUNCTION: (Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen. {ECO:0000269|PubMed:25139904}. |
| P07900 | HSP90AA1 | S709 | ochoa | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}. |
| P08758 | ANXA5 | S37 | ochoa | Annexin A5 (Anchorin CII) (Annexin V) (Annexin-5) (Calphobindin I) (CPB-I) (Endonexin II) (Lipocortin V) (Placental anticoagulant protein 4) (PP4) (Placental anticoagulant protein I) (PAP-I) (Thromboplastin inhibitor) (Vascular anticoagulant-alpha) (VAC-alpha) | This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. |
| P0CG47 | UBB | S20 | ochoa | Polyubiquitin-B [Cleaved into: Ubiquitin] | [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000303|PubMed:19754430}. |
| P0CG48 | UBC | S20 | ochoa | Polyubiquitin-C [Cleaved into: Ubiquitin] | [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. During ubiquitination, the acceptor ubiquitin is positioned in the active site via direct interaction with the E2 ubiquitin-conjugating enzymes such as UBE2R2 (PubMed:38326650). As a monoubiquitin, its C-terminal glycine is recognized as a C-degron by Cul2-RING (CRL2) E3 ubiquitin-protein ligase complexes (PubMed:39548056). {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000269|PubMed:38326650, ECO:0000269|PubMed:39548056, ECO:0000303|PubMed:19754430}. |
| P0DJD0 | RGPD1 | S1299 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD0 | RGPD1 | S1306 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | S1307 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P0DJD1 | RGPD2 | S1314 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P10451 | SPP1 | S258 | ochoa|psp | Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin) | Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. {ECO:0000250|UniProtKB:P31096}.; FUNCTION: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. {ECO:0000250|UniProtKB:P10923}. |
| P11831 | SRF | S253 | psp | Serum response factor (SRF) | SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. Required for cardiac differentiation and maturation. {ECO:0000250|UniProtKB:Q9JM73}. |
| P13637 | ATP1A3 | S206 | ochoa | Sodium/potassium-transporting ATPase subunit alpha-3 (Na(+)/K(+) ATPase alpha-3 subunit) (EC 7.2.2.13) (Na(+)/K(+) ATPase alpha(III) subunit) (Sodium pump subunit alpha-3) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. {ECO:0000269|PubMed:33880529}. |
| P20648 | ATP4A | S227 | ochoa | Potassium-transporting ATPase alpha chain 1 (EC 7.2.2.19) (Gastric H(+)/K(+) ATPase subunit alpha) (Proton pump) | The catalytic subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Uses ATP as an energy source to pump H(+) ions to the gastric lumen while transporting K(+) ion from the lumen into the cell (By similarity). Remarkably generates a million-fold proton gradient across the gastric parietal cell membrane, acidifying the gastric juice down to pH 1 (By similarity). Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). The release of the H(+) ion in the stomach lumen is followed by binding of K(+) ion converting the pump conformation back to the E1 state (By similarity). {ECO:0000250|UniProtKB:P09626, ECO:0000250|UniProtKB:P19156, ECO:0000250|UniProtKB:Q64436}. |
| P23760 | PAX3 | S205 | ochoa|psp | Paired box protein Pax-3 (HuP2) | Transcription factor that may regulate cell proliferation, migration and apoptosis. Involved in neural development and myogenesis. Transcriptional activator of MITF, acting synergistically with SOX10 (PubMed:21965087). {ECO:0000269|PubMed:16951170, ECO:0000269|PubMed:21965087}. |
| P25490 | YY1 | S118 | ochoa|psp | Transcriptional repressor protein YY1 (Delta transcription factor) (INO80 complex subunit S) (NF-E1) (Yin and yang 1) (YY-1) | Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site (PubMed:15329343, PubMed:17721549, PubMed:24326773, PubMed:25787250). Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity (PubMed:15329343, PubMed:17721549, PubMed:24326773, PubMed:25787250). The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes (PubMed:15329343, PubMed:17721549, PubMed:24326773, PubMed:25787250). Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression (PubMed:15329343, PubMed:17721549, PubMed:24326773, PubMed:25787250). For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence (PubMed:1655281). Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions (PubMed:15329343). May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed (PubMed:11158321). Involved in DNA repair (PubMed:18026119, PubMed:28575647). In vitro, binds to DNA recombination intermediate structures (Holliday junctions). Plays a role in regulating enhancer activation (PubMed:28575647). Recruits the PR-DUB complex to specific gene-regulatory regions (PubMed:20805357). {ECO:0000269|PubMed:11158321, ECO:0000269|PubMed:15329343, ECO:0000269|PubMed:1655281, ECO:0000269|PubMed:17721549, ECO:0000269|PubMed:18026119, ECO:0000269|PubMed:20805357, ECO:0000269|PubMed:24326773, ECO:0000269|PubMed:25787250, ECO:0000269|PubMed:28575647}.; FUNCTION: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; proposed to target the INO80 complex to YY1-responsive elements. {ECO:0000269|PubMed:17721549, ECO:0000269|PubMed:18026119}. |
| P27448 | MARK3 | S606 | psp | MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (C-TAK1) (cTAK1) (Cdc25C-associated protein kinase 1) (ELKL motif kinase 2) (EMK-2) (Protein kinase STK10) (Ser/Thr protein kinase PAR-1) (Par-1a) (Serine/threonine-protein kinase p78) | Serine/threonine-protein kinase (PubMed:16822840, PubMed:16980613, PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Phosphorylates CDC25C on 'Ser-216' (PubMed:12941695). Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol (PubMed:16822840). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714). Phosphorylates PKP2 and KSR1 (PubMed:12941695). {ECO:0000269|PubMed:12941695, ECO:0000269|PubMed:16822840, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:23666762, ECO:0000269|PubMed:28087714}. |
| P33981 | TTK | S291 | psp | Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT) | Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (PubMed:18243099, PubMed:28441529, PubMed:29162720). Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint (PubMed:18243099, PubMed:29162720). Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore (PubMed:18243099). Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments (PubMed:28441529). Phosphorylates KNL1, KNTC1 and autophosphorylates (PubMed:28441529). Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment (PubMed:30785839). {ECO:0000269|PubMed:18243099, ECO:0000269|PubMed:28441529, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:30785839}. |
| P33991 | MCM4 | S131 | ochoa | DNA replication licensing factor MCM4 (EC 3.6.4.12) (CDC21 homolog) (P1-CDC21) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:25661590, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:16899510, PubMed:25661590, PubMed:32453425, PubMed:9305914). {ECO:0000269|PubMed:16899510, ECO:0000269|PubMed:25661590, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9305914}. |
| P35236 | PTPN7 | S63 | ochoa | Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48) (Hematopoietic protein-tyrosine phosphatase) (HEPTP) (Protein-tyrosine phosphatase LC-PTP) | Protein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1. Plays a role in the regulation of T and B-lymphocyte development and signal transduction. {ECO:0000269|PubMed:10206983, ECO:0000269|PubMed:10559944, ECO:0000269|PubMed:10702794, ECO:0000269|PubMed:1510684, ECO:0000269|PubMed:1530918, ECO:0000269|PubMed:9624114}. |
| P35637 | FUS | S346 | ochoa | RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein) | DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response (PubMed:27731383). Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing (PubMed:26124092). Also binds its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay (PubMed:24204307). Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (PubMed:10567410). In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity). {ECO:0000250|UniProtKB:P56959, ECO:0000269|PubMed:10567410, ECO:0000269|PubMed:21256132, ECO:0000269|PubMed:24204307, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27731383}. |
| P38936 | CDKN1A | S114 | psp | Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (Melanoma differentiation-associated protein 6) (MDA-6) (p21) | Plays an important role in controlling cell cycle progression and DNA damage-induced G2 arrest (PubMed:9106657). Involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Also involved in p53-independent DNA damage-induced G2 arrest mediated by CREB3L1 in astrocytes and osteoblasts (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (PubMed:11595739). Negatively regulates the CDK4- and CDK6-driven phosphorylation of RB1 in keratinocytes, thereby resulting in the release of E2F1 and subsequent transcription of E2F1-driven G1/S phase promoting genes (By similarity). {ECO:0000250|UniProtKB:P39689, ECO:0000269|PubMed:11595739, ECO:0000269|PubMed:8242751, ECO:0000269|PubMed:9106657}. |
| P46734 | MAP2K3 | S253 | ochoa | Dual specificity mitogen-activated protein kinase kinase 3 (MAP kinase kinase 3) (MAPKK 3) (EC 2.7.12.2) (MAPK/ERK kinase 3) (MEK 3) (Stress-activated protein kinase kinase 2) (SAPK kinase 2) (SAPKK-2) (SAPKK2) | Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. {ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:8622669}. |
| P48681 | NES | S913 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P48681 | NES | S1409 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P49116 | NR2C2 | S98 | ochoa | Nuclear receptor subfamily 2 group C member 2 (Orphan nuclear receptor TAK1) (Orphan nuclear receptor TR4) (Testicular receptor 4) | Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation. {ECO:0000250, ECO:0000269|PubMed:10347174, ECO:0000269|PubMed:10644740, ECO:0000269|PubMed:17974920, ECO:0000269|PubMed:7779113, ECO:0000269|PubMed:9556573}. |
| P49792 | RANBP2 | S2290 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P49792 | RANBP2 | S2297 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P50993 | ATP1A2 | S214 | ochoa | Sodium/potassium-transporting ATPase subunit alpha-2 (Na(+)/K(+) ATPase alpha-2 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-2) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients. {ECO:0000269|PubMed:33880529}. |
| P52948 | NUP98 | S997 | ochoa | Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)] | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC (PubMed:33097660). May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:33097660}.; FUNCTION: (Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro) (PubMed:23523133). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro) (PubMed:23523133). {ECO:0000269|PubMed:23523133}. |
| P54278 | PMS2 | S405 | ochoa | Mismatch repair endonuclease PMS2 (EC 3.1.-.-) (DNA mismatch repair protein PMS2) (PMS1 protein homolog 2) | Component of the post-replicative DNA mismatch repair system (MMR) (PubMed:30653781, PubMed:35189042). Heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Possesses an ATPase activity, but in the absence of gross structural changes, ATP hydrolysis may not be necessary for proficient mismatch repair (PubMed:35189042). {ECO:0000269|PubMed:16873062, ECO:0000269|PubMed:18206974, ECO:0000269|PubMed:23709753, ECO:0000269|PubMed:30653781, ECO:0000269|PubMed:35189042}. |
| P62979 | RPS27A | S20 | ochoa | Ubiquitin-ribosomal protein eS31 fusion protein (Ubiquitin carboxyl extension protein 80) [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31 (40S ribosomal protein S27a)] | [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000303|PubMed:19754430}.; FUNCTION: [Small ribosomal subunit protein eS31]: Component of the 40S subunit of the ribosome (PubMed:23636399, PubMed:9582194). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:23636399, PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797, ECO:0000305|PubMed:9582194}. |
| P62987 | UBA52 | S20 | ochoa | Ubiquitin-ribosomal protein eL40 fusion protein (CEP52) (Ubiquitin A-52 residue ribosomal protein fusion product 1) [Cleaved into: Ubiquitin; Large ribosomal subunit protein eL40 (60S ribosomal protein L40) (rpL40)] | [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000303|PubMed:19754430}.; FUNCTION: [Large ribosomal subunit protein eL40]: Component of the 60S subunit of the ribosome (PubMed:23169626, PubMed:23636399, PubMed:32669547, PubMed:39048817, PubMed:39103523). Ribosomal protein L40 is essential for translation of a subset of cellular transcripts, and especially for cap-dependent translation of vesicular stomatitis virus mRNAs (PubMed:23169626, PubMed:23636399, PubMed:32669547, PubMed:39048817, PubMed:39103523). {ECO:0000269|PubMed:23169626, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000269|PubMed:39048817, ECO:0000269|PubMed:39103523}. |
| P78527 | PRKDC | S2672 | ochoa|psp | DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) | Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250|UniProtKB:P97313, ECO:0000269|PubMed:10026262, ECO:0000269|PubMed:10467406, ECO:0000269|PubMed:11889123, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12509254, ECO:0000269|PubMed:12649176, ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:14612514, ECO:0000269|PubMed:14627815, ECO:0000269|PubMed:14704337, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:15262962, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:1597196, ECO:0000269|PubMed:16046194, ECO:0000269|PubMed:16397295, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:2247066, ECO:0000269|PubMed:2507541, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30247612, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33854234, ECO:0000269|PubMed:34352203, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:8407951, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9362500, ECO:0000269|PubMed:9363941, ECO:0000269|PubMed:9679063}. |
| Q00653 | NFKB2 | S715 | psp | Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10 protein) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) (Oncogene Lyt-10) (Lyt10) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit] | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65. In concert with RELB, regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. {ECO:0000269|PubMed:7925301}. |
| Q00987 | MDM2 | S242 | psp | E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2) | E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome (PubMed:29681526). Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also a component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (PubMed:12821780, PubMed:15053880, PubMed:15195100, PubMed:15632057, PubMed:16337594, PubMed:17290220, PubMed:19098711, PubMed:19219073, PubMed:19837670, PubMed:19965871, PubMed:20173098, PubMed:20385133, PubMed:20858735, PubMed:22128911). Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (By similarity). Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity). Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis (PubMed:30879903). Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis (PubMed:30879903). {ECO:0000250|UniProtKB:P23804, ECO:0000269|PubMed:12821780, ECO:0000269|PubMed:15053880, ECO:0000269|PubMed:15195100, ECO:0000269|PubMed:15632057, ECO:0000269|PubMed:16337594, ECO:0000269|PubMed:17290220, ECO:0000269|PubMed:19098711, ECO:0000269|PubMed:19219073, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:20173098, ECO:0000269|PubMed:20385133, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:22128911, ECO:0000269|PubMed:29681526, ECO:0000269|PubMed:30879903}. |
| Q01484 | ANK2 | S1461 | ochoa | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}. |
| Q01804 | OTUD4 | S905 | ochoa | OTU domain-containing protein 4 (EC 3.4.19.12) (HIV-1-induced protein HIN-1) | Deubiquitinase which hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein (PubMed:23827681, PubMed:25944111, PubMed:29395066). May negatively regulate inflammatory and pathogen recognition signaling in innate immune response. Upon phosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptor and Toll-like receptor signaling pathway, specifically deubiquitinates 'Lys-63'-polyubiquitinated MYD88 adapter protein triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators (PubMed:29395066). Independently of the catalytic activity, acts as a scaffold for alternative deubiquitinases to assemble specific deubiquitinase-substrate complexes. Associates with USP7 and USP9X deubiquitinases to stabilize alkylation repair enzyme ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111). {ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:25944111, ECO:0000269|PubMed:29395066}. |
| Q07021 | C1QBP | S87 | ochoa | Complement component 1 Q subcomponent-binding protein, mitochondrial (ASF/SF2-associated protein p32) (Glycoprotein gC1qBP) (C1qBP) (Hyaluronan-binding protein 1) (Mitochondrial matrix protein p32) (gC1q-R protein) (p33) (SF2AP32) | Multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, protein synthesis in mitochondria, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing (PubMed:10022843, PubMed:10479529, PubMed:10722602, PubMed:11086025, PubMed:11859136, PubMed:15243141, PubMed:16140380, PubMed:16177118, PubMed:17881511, PubMed:18676636, PubMed:19004836, PubMed:19164550, PubMed:20810993, PubMed:21536856, PubMed:21544310, PubMed:22700724, PubMed:28942965, PubMed:8662673, PubMed:8710908, PubMed:9461517). At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades (PubMed:10479529, PubMed:11859136, PubMed:8662673, PubMed:8710908). Putative receptor for C1q; specifically binds to the globular 'heads' of C1q thus inhibiting C1; may perform the receptor function through a complex with C1qR/CD93 (PubMed:20810993, PubMed:8195709). In complex with cytokeratin-1/KRT1 is a high affinity receptor for kininogen-1/HMWK (PubMed:21544310). Can also bind other plasma proteins, such as coagulation factor XII leading to its autoactivation. May function to bind initially fluid kininogen-1 to the cell membrane. The secreted form may enhance both extrinsic and intrinsic coagulation pathways. It is postulated that the cell surface form requires docking with transmembrane proteins for downstream signaling which might be specific for a cell-type or response. By acting as C1q receptor is involved in chemotaxis of immature dendritic cells and neutrophils and is proposed to signal through CD209/DC-SIGN on immature dendritic cells, through integrin alpha-4/beta-1 during trophoblast invasion of the decidua, and through integrin beta-1 during endothelial cell adhesion and spreading (PubMed:16140380, PubMed:22700724, PubMed:9461517). Signaling involved in inhibition of innate immune response is implicating the PI3K-AKT/PKB pathway (PubMed:16177118). Required for protein synthesis in mitochondria (PubMed:28942965). In mitochondrial translation may be involved in formation of functional 55S mitoribosomes; the function seems to involve its RNA-binding activity (By similarity). Acts as a RNA modification reader, which specifically recognizes and binds mitochondrial RNAs modified by C5-methylcytosine (m5C) in response to stress, and promotes recruitment of the mitochondrial degradosome complex, leading to their degradation (PubMed:39019044). May be involved in the nucleolar ribosome maturation process; the function may involve the exchange of FBL for RRP1 in the association with pre-ribosome particles (By similarity). Involved in regulation of RNA splicing by inhibiting the RNA-binding capacity of SRSF1 and its phosphorylation (PubMed:10022843, PubMed:21536856). Is required for the nuclear translocation of splicing factor U2AF1L4 (By similarity). Involved in regulation of CDKN2A- and HRK-mediated apoptosis. Stabilizes mitochondrial CDKN2A isoform smARF (PubMed:17486078). May be involved in regulation of FOXC1 transcriptional activity and NFY/CCAAT-binding factor complex-mediated transcription (PubMed:15243141, PubMed:18676636). May play a role in antibacterial defense as it can bind to cell surface hyaluronan and inhibit Streptococcus pneumoniae hyaluronate lyase (PubMed:19004836). May be involved in modulation of the immune response; ligation by HCV core protein is resulting in suppression of interleukin-12 production in monocyte-derived dendritic cells (PubMed:11086025, PubMed:17881511). Involved in regulation of antiviral response by inhibiting RIGI- and IFIH1-mediated signaling pathways probably involving its association with MAVS after viral infection (PubMed:19164550). Acts as a regulator of DNA repair via homologous recombination by inhibiting the activity of MRE11: interacts with unphosphorylated MRE11 and RAD50 in absence of DNA damage, preventing formation and activity of the MRN complex. Following DNA damage, dissociates from phosphorylated MRE11, allowing formation of the MRN complex (PubMed:31353207). {ECO:0000250|UniProtKB:O35658, ECO:0000269|PubMed:10022843, ECO:0000269|PubMed:10479529, ECO:0000269|PubMed:10722602, ECO:0000269|PubMed:11086025, ECO:0000269|PubMed:11859136, ECO:0000269|PubMed:15243141, ECO:0000269|PubMed:16140380, ECO:0000269|PubMed:16177118, ECO:0000269|PubMed:17486078, ECO:0000269|PubMed:17881511, ECO:0000269|PubMed:18676636, ECO:0000269|PubMed:19004836, ECO:0000269|PubMed:19164550, ECO:0000269|PubMed:20810993, ECO:0000269|PubMed:21536856, ECO:0000269|PubMed:21544310, ECO:0000269|PubMed:22700724, ECO:0000269|PubMed:28942965, ECO:0000269|PubMed:31353207, ECO:0000269|PubMed:39019044, ECO:0000269|PubMed:8195709, ECO:0000269|PubMed:8662673, ECO:0000269|PubMed:8710908, ECO:0000269|PubMed:9461517}.; FUNCTION: (Microbial infection) Involved in HIV-1 replication, presumably by contributing to splicing of viral RNA. {ECO:0000269|PubMed:12833064}.; FUNCTION: (Microbial infection) In infection processes acts as an attachment site for microbial proteins, including Listeria monocytogenes internalin B (InlB) and Staphylococcus aureus protein A. {ECO:0000269|PubMed:10722602, ECO:0000269|PubMed:10747014, ECO:0000269|PubMed:12411480}.; FUNCTION: (Microbial infection) Involved in replication of Rubella virus. {ECO:0000269|PubMed:12034482}. |
| Q12912 | IRAG2 | S345 | ochoa | Inositol 1,4,5-triphosphate receptor associated 2 (Lymphoid-restricted membrane protein) (Protein Jaw1) [Cleaved into: Processed inositol 1,4,5-triphosphate receptor associated 2] | Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion. Plays a role in maintaining nuclear shape, maybe as a component of the LINC complex and through interaction with microtubules. Plays a role in the regulation of cellular excitability by regulating the hyperpolarization-activated cyclic nucleotide-gated HCN4 channel activity (By similarity). {ECO:0000250|UniProtKB:Q60664}. |
| Q12955 | ANK3 | S1445 | ochoa | Ankyrin-3 (ANK-3) (Ankyrin-G) | Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (PubMed:7836469). In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). {ECO:0000250|UniProtKB:G5E8K5, ECO:0000250|UniProtKB:O70511, ECO:0000269|PubMed:23903368, ECO:0000269|PubMed:7836469}.; FUNCTION: [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. {ECO:0000305|PubMed:17974005}. |
| Q13439 | GOLGA4 | S118 | ochoa | Golgin subfamily A member 4 (256 kDa golgin) (Golgin-245) (Protein 72.1) (Trans-Golgi p230) | Involved in vesicular trafficking at the Golgi apparatus level. May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1. Involved in endosome-to-Golgi trafficking (PubMed:29084197). {ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:29084197}. |
| Q13557 | CAMK2D | S334 | ochoa|psp | Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program (PubMed:17179159). Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis (PubMed:16690701). May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q6PHZ2, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:17179159}. |
| Q13769 | THOC5 | S312 | ochoa|psp | THO complex subunit 5 (Functional spliceosome-associated protein 79) (fSAP79) (NF2/meningioma region protein pK1.3) (Placental protein 39.2) (PP39.2) (hTREX90) | Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). Plays a key structural role in the oligomerization of the THO-DDX39B complex (PubMed:33191911). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15833825, PubMed:15998806, PubMed:17190602). THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability (PubMed:18974867). Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5' region of target genes; probably mediates association of the TREX and CFIm complexes (PubMed:23685434). {ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:18974867, ECO:0000269|PubMed:23685434, ECO:0000269|PubMed:33191911}.; FUNCTION: Regulates the expression of myeloid transcription factors CEBPA, CEBPB and GAB2 by enhancing the levels of phosphatidylinositol 3,4,5-trisphosphate. May be involved in the differentiation of granulocytes and adipocytes. Essential for hematopoietic primitive cell survival and plays an integral role in monocytic development. {ECO:0000250|UniProtKB:Q8BKT7}.; FUNCTION: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269|PubMed:18974867}. |
| Q13950 | RUNX2 | S247 | ochoa|psp | Runt-related transcription factor 2 (Acute myeloid leukemia 3 protein) (Core-binding factor subunit alpha-1) (CBF-alpha-1) (Oncogene AML-3) (Osteoblast-specific transcription factor 2) (OSF-2) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEA2-alpha A) (PEBP2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit) | Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis (PubMed:28505335, PubMed:28703881, PubMed:28738062). Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation. {ECO:0000250, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:28505335, ECO:0000269|PubMed:28703881, ECO:0000269|PubMed:28738062}. |
| Q14676 | MDC1 | S218 | psp | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14739 | LBR | S130 | ochoa | Delta(14)-sterol reductase LBR (Delta-14-SR) (EC 1.3.1.70) (3-beta-hydroxysterol Delta (14)-reductase) (C-14 sterol reductase) (C14SR) (Integral nuclear envelope inner membrane protein) (LMN2R) (Lamin-B receptor) (Sterol C14-reductase) | Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis (PubMed:12618959, PubMed:16784888, PubMed:21327084, PubMed:27336722, PubMed:9630650). Plays a critical role in myeloid cell cholesterol biosynthesis which is essential to both myeloid cell growth and functional maturation (By similarity). Mediates the activation of NADPH oxidases, perhaps by maintaining critical levels of cholesterol required for membrane lipid raft formation during neutrophil differentiation (By similarity). Anchors the lamina and the heterochromatin to the inner nuclear membrane (PubMed:10828963). {ECO:0000250|UniProtKB:Q3U9G9, ECO:0000269|PubMed:10828963, ECO:0000269|PubMed:12618959, ECO:0000269|PubMed:16784888, ECO:0000269|PubMed:21327084, ECO:0000269|PubMed:27336722, ECO:0000269|PubMed:9630650}. |
| Q15459 | SF3A1 | S359 | ochoa | Splicing factor 3A subunit 1 (SF3a120) (Spliceosome-associated protein 114) (SAP 114) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:10882114, PubMed:11533230, PubMed:32494006). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:10882114, PubMed:11533230, PubMed:32494006). Within the 17S U2 SnRNP complex, SF3A1 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex (PubMed:10882114, PubMed:11533230). Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes (PubMed:29360106, PubMed:30315277). {ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:11533230, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:32494006}. |
| Q15527 | SURF2 | S183 | ochoa | Surfeit locus protein 2 (Surf-2) | None |
| Q2M389 | WASHC4 | S19 | ochoa | WASH complex subunit 4 (Strumpellin and WASH-interacting protein) (SWIP) (WASH complex subunit SWIP) | Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. {ECO:0000269|PubMed:19922875, ECO:0000269|PubMed:20498093, ECO:0000303|PubMed:21498477}. |
| Q2TAL5 | SMTNL2 | S141 | ochoa | Smoothelin-like protein 2 | None |
| Q32MZ4 | LRRFIP1 | S124 | ochoa | Leucine-rich repeat flightless-interacting protein 1 (LRR FLII-interacting protein 1) (GC-binding factor 2) (TAR RNA-interacting protein) | Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:10364563, ECO:0000269|PubMed:14522076, ECO:0000269|PubMed:16199883, ECO:0000269|PubMed:19265123, ECO:0000269|PubMed:9705290}. |
| Q4KMP7 | TBC1D10B | S288 | ochoa | TBC1 domain family member 10B (Rab27A-GAP-beta) | Acts as a GTPase-activating protein for RAB3A, RAB22A, RAB27A, and RAB35. Does not act on RAB2A and RAB6A. {ECO:0000269|PubMed:16923811, ECO:0000269|PubMed:19077034}. |
| Q52LW3 | ARHGAP29 | S519 | ochoa | Rho GTPase-activating protein 29 (PTPL1-associated RhoGAP protein 1) (Rho-type GTPase-activating protein 29) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis. {ECO:0000269|PubMed:15752761, ECO:0000269|PubMed:9305890}. |
| Q53T59 | HS1BP3 | S158 | ochoa | HCLS1-binding protein 3 (HS1-binding protein 3) (HSP1BP-3) | May be a modulator of IL-2 signaling. {ECO:0000250}. |
| Q5T200 | ZC3H13 | S1423 | ochoa | Zinc finger CCCH domain-containing protein 13 | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}. |
| Q5T3I0 | GPATCH4 | S128 | ochoa | G patch domain-containing protein 4 | None |
| Q5T5X7 | BEND3 | S181 | ochoa | BEN domain-containing protein 3 | Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination (PubMed:21914818, PubMed:26100909). Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites (By similarity). Stimulates the ERCC6L translocase and ATPase activities (PubMed:28977671). {ECO:0000250|UniProtKB:Q6PAL0, ECO:0000269|PubMed:21914818, ECO:0000269|PubMed:26100909, ECO:0000269|PubMed:28977671}. |
| Q5VT52 | RPRD2 | S826 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q641Q2 | WASHC2A | S375 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
| Q641Q2 | WASHC2A | S1142 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
| Q68D20 | PMS2CL | S19 | ochoa | Protein PMS2CL (PMS2-C terminal-like protein) | None |
| Q6PJF5 | RHBDF2 | S291 | ochoa | Inactive rhomboid protein 2 (iRhom2) (Rhomboid 5 homolog 2) (Rhomboid family member 2) (Rhomboid veinlet-like protein 5) (Rhomboid veinlet-like protein 6) | Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. {ECO:0000250|UniProtKB:Q80WQ6}. |
| Q6WN34 | CHRDL2 | S179 | ochoa | Chordin-like protein 2 (Breast tumor novel factor 1) (BNF-1) (Chordin-related protein 2) | May inhibit BMPs activity by blocking their interaction with their receptors. Has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal cells, by preventing or reducing the rate of matrix accumulation (By similarity). Implicated in tumor angiogenesis. May play a role during myoblast and osteoblast differentiation, and maturation. {ECO:0000250, ECO:0000269|PubMed:12853144, ECO:0000269|PubMed:15094188}. |
| Q7L804 | RAB11FIP2 | S388 | ochoa | Rab11 family-interacting protein 2 (Rab11-FIP2) (NRip11) | A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity. Plays an essential role in phagocytosis through a mechanism involving TICAM2, RAC1 and CDC42 Rho GTPases for controlling actin-dynamics. {ECO:0000269|PubMed:12364336, ECO:0000269|PubMed:15304524, ECO:0000269|PubMed:16251358, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:19542231, ECO:0000269|PubMed:30883606}. |
| Q7Z3J3 | RGPD4 | S1315 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z3J3 | RGPD4 | S1322 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q86W56 | PARG | S197 | ochoa | Poly(ADP-ribose) glycohydrolase (EC 3.2.1.143) | Poly(ADP-ribose) glycohydrolase that degrades poly(ADP-ribose) by hydrolyzing the ribose-ribose bonds present in poly(ADP-ribose) (PubMed:15450800, PubMed:21892188, PubMed:23102699, PubMed:23474714, PubMed:33186521, PubMed:34019811, PubMed:34321462). PARG acts both as an endo- and exoglycosidase, releasing poly(ADP-ribose) of different length as well as ADP-ribose monomers (PubMed:23102699, PubMed:23481255). It is however unable to cleave the ester bond between the terminal ADP-ribose and ADP-ribosylated residues, leaving proteins that are mono-ADP-ribosylated (PubMed:21892188, PubMed:23474714, PubMed:33186521). Poly(ADP-ribose) is synthesized after DNA damage is only present transiently and is rapidly degraded by PARG (PubMed:23102699, PubMed:34019811). Required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress, while it is not required for recovery from transient replicative stress (PubMed:24906880). Responsible for the prevalence of mono-ADP-ribosylated proteins in cells, thanks to its ability to degrade poly(ADP-ribose) without cleaving the terminal protein-ribose bond (PubMed:33186521). Required for retinoid acid-dependent gene transactivation, probably by removing poly(ADP-ribose) from histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters (PubMed:23102699). Involved in the synthesis of ATP in the nucleus, together with PARP1, NMNAT1 and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000269|PubMed:15450800, ECO:0000269|PubMed:21892188, ECO:0000269|PubMed:23102699, ECO:0000269|PubMed:23474714, ECO:0000269|PubMed:23481255, ECO:0000269|PubMed:24906880, ECO:0000269|PubMed:27257257, ECO:0000269|PubMed:33186521, ECO:0000269|PubMed:34019811, ECO:0000269|PubMed:34321462}. |
| Q8IVL1 | NAV2 | S1019 | ochoa | Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2) | Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs. {ECO:0000269|PubMed:12214280, ECO:0000269|PubMed:15158073}. |
| Q8IYH5 | ZZZ3 | S474 | ochoa | ZZ-type zinc finger-containing protein 3 | Histone H3 reader that is required for the ATAC complex-mediated maintenance of histone acetylation and gene activation (PubMed:30217978). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed:19103755). {ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:30217978}. |
| Q8IYL3 | C1orf174 | S189 | ochoa | UPF0688 protein C1orf174 | None |
| Q8N490 | PNKD | S128 | psp | Probable thioesterase PNKD (EC 3.1.2.-) (Myofibrillogenesis regulator 1) (MR-1) (Paroxysmal nonkinesiogenic dyskinesia protein) (Trans-activated by hepatitis C virus core protein 2) | Probable thioesterase that may play a role in cellular detoxification processes; it likely acts on a yet-unknown alpha-hydroxythioester substrate (Probable). In vitro, it is able to catalyze the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid at very low rate, though this reaction is not physiologically relevant in vivo (PubMed:21487022). {ECO:0000269|PubMed:21487022, ECO:0000305|PubMed:21487022}. |
| Q8NC54 | KCT2 | S165 | ochoa | Keratinocyte-associated transmembrane protein 2 | None |
| Q8NEY8 | PPHLN1 | S92 | ochoa | Periphilin-1 (CDC7 expression repressor) (CR) (Gastric cancer antigen Ga50) | Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3. In the HUSH complex, contributes to the maintenance of the complex at chromatin (PubMed:26022416). Acts as a transcriptional corepressor and regulates the cell cycle, probably via the HUSH complex (PubMed:15474462, PubMed:17963697). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). May be involved in epithelial differentiation by contributing to epidermal integrity and barrier formation (PubMed:12853457). {ECO:0000269|PubMed:15474462, ECO:0000269|PubMed:17963697, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:30487602, ECO:0000305|PubMed:12853457}. |
| Q8NFW9 | MYRIP | S561 | ochoa | Rab effector MyRIP (Exophilin-8) (Myosin-VIIa- and Rab-interacting protein) (Synaptotagmin-like protein lacking C2 domains C) (SlaC2-c) (Slp homolog lacking C2 domains c) | Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments. Functions as a protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release (By similarity). {ECO:0000250}. |
| Q8NFZ8 | CADM4 | S354 | ochoa | Cell adhesion molecule 4 (Immunoglobulin superfamily member 4C) (IgSF4C) (Nectin-like protein 4) (NECL-4) (TSLC1-like protein 2) | Involved in the cell-cell adhesion. Has calcium- and magnesium-independent cell-cell adhesion activity. May have tumor-suppressor activity. {ECO:0000269|PubMed:16261159}. |
| Q8NG31 | KNL1 | S945 | ochoa | Outer kinetochore KNL1 complex subunit KNL1 (ALL1-fused gene from chromosome 15q14 protein) (AF15q14) (Bub-linking kinetochore protein) (Blinkin) (Cancer susceptibility candidate gene 5 protein) (Cancer/testis antigen 29) (CT29) (Kinetochore scaffold 1) (Kinetochore-null protein 1) (Protein CASC5) (Protein D40/AF15q14) | Acts as a component of the outer kinetochore KNL1 complex that serves as a docking point for spindle assembly checkpoint components and mediates microtubule-kinetochore interactions (PubMed:15502821, PubMed:17981135, PubMed:18045986, PubMed:19893618, PubMed:21199919, PubMed:22000412, PubMed:22331848, PubMed:27881301, PubMed:30100357). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules (PubMed:18045986, PubMed:19893618, PubMed:27881301). The outer kinetochore is made up of the ten-subunit KMN network, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:38459127, PubMed:38459128). Required for kinetochore binding by a distinct subset of kMAPs (kinetochore-bound microtubule-associated proteins) and motors (PubMed:19893618). Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore (PubMed:18045986, PubMed:27881301). Can bind either to microtubules or to the protein phosphatase 1 (PP1) catalytic subunits PPP1CA and PPP1CC (via overlapping binding sites), it has higher affinity for PP1 (PubMed:30100357). Recruits MAD2L1 to the kinetochore and also directly links BUB1 and BUB1B to the kinetochore (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:22331848, PubMed:25308863). In addition to orienting mitotic chromosomes, it is also essential for alignment of homologous chromosomes during meiotic metaphase I (By similarity). In meiosis I, required to activate the spindle assembly checkpoint at unattached kinetochores to correct erroneous kinetochore-microtubule attachments (By similarity). {ECO:0000250|UniProtKB:Q66JQ7, ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:17981135, ECO:0000269|PubMed:18045986, ECO:0000269|PubMed:19893618, ECO:0000269|PubMed:21199919, ECO:0000269|PubMed:22000412, ECO:0000269|PubMed:22331848, ECO:0000269|PubMed:25308863, ECO:0000269|PubMed:27881301, ECO:0000269|PubMed:30100357, ECO:0000269|PubMed:38459127, ECO:0000269|PubMed:38459128}. |
| Q8NHP6 | MOSPD2 | S266 | ochoa | Motile sperm domain-containing protein 2 | Endoplasmic reticulum-anchored protein that mediates the formation of contact sites between the endoplasmic (ER) and endosomes, mitochondria or Golgi through interaction with conventional- and phosphorylated-FFAT-containing organelle-bound proteins (PubMed:29858488, PubMed:33124732, PubMed:35389430). In addition, forms endoplasmic reticulum (ER)-lipid droplets (LDs) contacts through a direct protein-membrane interaction and participates in LDs homeostasis (PubMed:35389430). The attachment mechanism involves an amphipathic helix that has an affinity for lipid packing defects present at the surface of LDs (PubMed:35389430). Promotes migration of primary monocytes and neutrophils, in response to various chemokines (PubMed:28137892). {ECO:0000269|PubMed:28137892, ECO:0000269|PubMed:29858488, ECO:0000269|PubMed:33124732, ECO:0000269|PubMed:35389430}. |
| Q8TE77 | SSH3 | S87 | ochoa | Protein phosphatase Slingshot homolog 3 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 3) (SSH-3L) (hSSH-3L) | Protein phosphatase which may play a role in the regulation of actin filament dynamics. Can dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly (By similarity). {ECO:0000250}. |
| Q92585 | MAML1 | S283 | ochoa | Mastermind-like protein 1 (Mam-1) | Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. {ECO:0000269|PubMed:11101851, ECO:0000269|PubMed:11390662, ECO:0000269|PubMed:12050117, ECO:0000269|PubMed:15546612, ECO:0000269|PubMed:17317671}. |
| Q92804 | TAF15 | S228 | ochoa | TATA-binding protein-associated factor 2N (68 kDa TATA-binding protein-associated factor) (TAF(II)68) (TAFII68) (RNA-binding protein 56) | RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Can enter the preinitiation complex together with the RNA polymerase II (Pol II). {ECO:0000269|PubMed:19124016, ECO:0000269|PubMed:21256132}. |
| Q92870 | APBB2 | S409 | ochoa | Amyloid beta precursor protein binding family B member 2 (Amyloid-beta (A4) precursor protein-binding family B member 2) (Protein Fe65-like 1) | Plays a role in the maintenance of lens transparency, and may also play a role in muscle cell strength (By similarity). Involved in hippocampal neurite branching and neuromuscular junction formation, as a result plays a role in spatial memory functioning (By similarity). Activates transcription of APP (PubMed:14527950). {ECO:0000250|UniProtKB:Q9DBR4, ECO:0000269|PubMed:14527950}. |
| Q96AJ1 | CLUAP1 | S324 | ochoa | Clusterin-associated protein 1 (Qilin) | Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling. {ECO:0000250|UniProtKB:Q8R3P7}. |
| Q96FZ2 | HMCES | S301 | ochoa | Abasic site processing protein HMCES (EC 4.-.-.-) (Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein) (ES cell-specific 5hmC-binding protein) (Peptidase HMCES) (EC 3.4.-.-) (SRAP domain-containing protein 1) | Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites (PubMed:30554877, PubMed:31235913, PubMed:31235915, PubMed:32307824, PubMed:32492421). Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue (PubMed:30554877, PubMed:31235913). Promotes error-free repair by protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks (PubMed:30554877). The HMCES DNA-protein cross-link is then either reversed or degraded (PubMed:30554877, PubMed:36608669, PubMed:37519246, PubMed:37950866). HMCES is able to catalyze the reversal of its thiazolidine cross-link and cycle between a cross-link and a non-cross-linked state depending on DNA context: mediates self-reversal of the thiazolidine cross-link in double stranded DNA, allowing APEX1 to initiate downstream repair of abasic sites (PubMed:37519246, PubMed:37950866). The HMCES DNA-protein cross-link can also be degraded by the SPRTN metalloprotease following unfolding by the BRIP1/FANCJ helicase (PubMed:36608669). Has preference for ssDNA, but can also accommodate double-stranded DNA with 3' or 5' overhang (dsDNA), and dsDNA-ssDNA 3' junction (PubMed:31235915, PubMed:31806351). Plays a protective role during somatic hypermutation of immunoglobulin genes in B-cells: acts via its ability to form covalent cross-links with abasic sites, thereby limiting the accumulation of deletions in somatic hypermutation target regions (PubMed:35450882). Also involved in class switch recombination (CSR) in B-cells independently of the formation of a DNA-protein cross-link: acts by binding and protecting ssDNA overhangs to promote DNA double-strand break repair through the microhomology-mediated alternative-end-joining (Alt-EJ) pathway (By similarity). Acts as a protease: mediates autocatalytic processing of its N-terminal methionine in order to expose the catalytic cysteine (By similarity). {ECO:0000250|UniProtKB:Q8R1M0, ECO:0000269|PubMed:30554877, ECO:0000269|PubMed:31235913, ECO:0000269|PubMed:31235915, ECO:0000269|PubMed:31806351, ECO:0000269|PubMed:32307824, ECO:0000269|PubMed:32492421, ECO:0000269|PubMed:35450882, ECO:0000269|PubMed:36608669, ECO:0000269|PubMed:37519246, ECO:0000269|PubMed:37950866}. |
| Q96H22 | CENPN | S235 | ochoa | Centromere protein N (CENP-N) (Interphase centromere complex protein 32) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA nucleosomes by CENPN is required for centromere assembly. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate. {ECO:0000269|PubMed:16622419, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:18007590, ECO:0000269|PubMed:19543270}. |
| Q96QT4 | TRPM7 | S1779 | psp | Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form] | Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644). {ECO:0000250|UniProtKB:Q923J1, ECO:0000269|PubMed:11385574, ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:18365021, ECO:0000269|PubMed:18394644, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:35561741, ECO:0000269|PubMed:36027648}.; FUNCTION: [TRPM7 channel, cleaved form]: The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling. {ECO:0000250|UniProtKB:Q923J1}.; FUNCTION: [TRPM7 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development. {ECO:0000250|UniProtKB:Q923J1}. |
| Q96T23 | RSF1 | S515 | ochoa | Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex) | Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:12972596, PubMed:28801535). Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively (PubMed:28801535). The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex (PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11788598, PubMed:11944984). {ECO:0000269|PubMed:11788598, ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:28801535}. |
| Q96T83 | SLC9A7 | S545 | ochoa | Sodium/hydrogen exchanger 7 (Na(+)/H(+) exchanger 7) (NHE-7) (Solute carrier family 9 member 7) | Golgi Na(+), K(+)/(H+) antiporter. Mediates the electoneutral influx of Na(+) or K(+) in exchange for H(+). May contribute to the regulation of Golgi apparatus volume and pH. {ECO:0000269|PubMed:11279194, ECO:0000269|PubMed:30335141}. |
| Q96TA1 | NIBAN2 | S425 | ochoa | Protein Niban 2 (Meg-3) (Melanoma invasion by ERK) (MINERVA) (Niban-like protein 1) (Protein FAM129B) | May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro. {ECO:0000269|PubMed:19362540, ECO:0000269|PubMed:21148485}. |
| Q99569 | PKP4 | S153 | ochoa | Plakophilin-4 (p0071) | Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269|PubMed:17115030}. |
| Q99733 | NAP1L4 | S309 | ochoa | Nucleosome assembly protein 1-like 4 (Nucleosome assembly protein 2) (NAP-2) | Acts as a histone chaperone in nucleosome assembly. {ECO:0000269|PubMed:9325046}. |
| Q9BXI6 | TBC1D10A | S39 | ochoa | TBC1 domain family member 10A (EBP50-PDX interactor of 64 kDa) (EPI64 protein) (Rab27A-GAP-alpha) | GTPase-activating protein (GAP) specific for RAB27A and RAB35 (PubMed:16923811, PubMed:30905672). Does not show GAP activity for RAB2A, RAB3A and RAB4A (PubMed:16923811). {ECO:0000269|PubMed:16923811, ECO:0000269|PubMed:30905672}. |
| Q9BZL6 | PRKD2 | S214 | ochoa | Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2) | Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion (PubMed:14743217, PubMed:15604256, PubMed:16928771, PubMed:17077180, PubMed:17951978, PubMed:17962809, PubMed:18262756, PubMed:19001381, PubMed:19192391, PubMed:23503467, PubMed:28428613). May potentiate mitogenesis induced by the neuropeptide bombesin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression (By similarity). In response to oxidative stress, is phosphorylated at Tyr-438 and Tyr-717 by ABL1, which leads to the activation of PRKD2 without increasing its catalytic activity, and mediates activation of NF-kappa-B (PubMed:15604256, PubMed:28428613). In response to the activation of the gastrin receptor CCKBR, is phosphorylated at Ser-244 by CSNK1D and CSNK1E, translocates to the nucleus, phosphorylates HDAC7, leading to nuclear export of HDAC7 and inhibition of HDAC7 transcriptional repression of NR4A1/NUR77 (PubMed:17962809). Upon TCR stimulation, is activated independently of ZAP70, translocates from the cytoplasm to the nucleus and is required for interleukin-2 (IL2) promoter up-regulation (PubMed:17077180). During adaptive immune responses, is required in peripheral T-lymphocytes for the production of the effector cytokines IL2 and IFNG after TCR engagement and for optimal induction of antibody responses to antigens (By similarity). In epithelial cells stimulated with lysophosphatidic acid (LPA), is activated through a PKC-dependent pathway and mediates LPA-stimulated interleukin-8 (IL8) secretion via a NF-kappa-B-dependent pathway (PubMed:16928771). During TCR-induced T-cell activation, interacts with and is activated by the tyrosine kinase LCK, which results in the activation of the NFAT transcription factors (PubMed:19192391). In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane and in polarized cells is involved in the transport of proteins from the TGN to the basolateral membrane (PubMed:14743217). Plays an important role in endothelial cell proliferation and migration prior to angiogenesis, partly through modulation of the expression of KDR/VEGFR2 and FGFR1, two key growth factor receptors involved in angiogenesis (PubMed:19001381). In secretory pathway, is required for the release of chromogranin-A (CHGA)-containing secretory granules from the TGN (PubMed:18262756). Downstream of PRKCA, plays important roles in angiotensin-2-induced monocyte adhesion to endothelial cells (PubMed:17951978). Plays a regulatory role in angiogenesis and tumor growth by phosphorylating a downstream mediator CIB1 isoform 2, resulting in vascular endothelial growth factor A (VEGFA) secretion (PubMed:23503467). {ECO:0000250|UniProtKB:Q8BZ03, ECO:0000269|PubMed:14743217, ECO:0000269|PubMed:15604256, ECO:0000269|PubMed:16928771, ECO:0000269|PubMed:17077180, ECO:0000269|PubMed:17951978, ECO:0000269|PubMed:17962809, ECO:0000269|PubMed:18262756, ECO:0000269|PubMed:19001381, ECO:0000269|PubMed:19192391, ECO:0000269|PubMed:23503467, ECO:0000269|PubMed:28428613}. |
| Q9C0C2 | TNKS1BP1 | S195 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9C0C2 | TNKS1BP1 | S983 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9H2G2 | SLK | S446 | ochoa | STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2) | Mediates apoptosis and actin stress fiber dissolution. {ECO:0000250}. |
| Q9H7N4 | SCAF1 | S872 | ochoa | Splicing factor, arginine/serine-rich 19 (SR-related C-terminal domain-associated factor 1) (SR-related and CTD-associated factor 1) (SR-related-CTD-associated factor) (SCAF) (Serine arginine-rich pre-mRNA splicing factor SR-A1) (SR-A1) | May function in pre-mRNA splicing. {ECO:0000250}. |
| Q9HCD6 | TANC2 | S22 | ochoa | Protein TANC2 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2) | Scaffolding protein in the dendritic spines which acts as immobile postsynaptic posts able to recruit KIF1A-driven dense core vesicles to dendritic spines. {ECO:0000269|PubMed:30021165}. |
| Q9HCH5 | SYTL2 | S466 | ochoa | Synaptotagmin-like protein 2 (Breast cancer-associated antigen SGA-72M) (Exophilin-4) | Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive. {ECO:0000269|PubMed:17182843, ECO:0000269|PubMed:18266782, ECO:0000269|PubMed:18812475}. |
| Q9NP71 | MLXIPL | S25 | ochoa | Carbohydrate-responsive element-binding protein (ChREBP) (Class D basic helix-loop-helix protein 14) (bHLHd14) (MLX interactor) (MLX-interacting protein-like) (WS basic-helix-loop-helix leucine zipper protein) (WS-bHLH) (Williams-Beuren syndrome chromosomal region 14 protein) | Binds DNA as a heterodimer with MLX/TCFL4 and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation (By similarity). Regulates transcription in response to changes in cellular carbohydrate abundance such as occurs during fasting to feeding metabolic transition. Refeeding stimulates MLXIPL/ChREBP transcription factor, leading to increased BCKDK to PPM1K expression ratio, phosphorylation and activation of ACLY that ultimately results in the generation of malonyl-CoA and oxaloacetate immediate substrates of de novo lipogenesis and gluconeogenesis, respectively (By similarity). {ECO:0000250|UniProtKB:Q2VPU4, ECO:0000250|UniProtKB:Q9HAP2}. |
| Q9NRZ9 | HELLS | S813 | ochoa | Lymphoid-specific helicase (EC 3.6.4.-) (Proliferation-associated SNF2-like protein) (SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6) | Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis (By similarity). {ECO:0000250|UniProtKB:Q60848}. |
| Q9NS87 | KIF15 | S560 | ochoa | Kinesin-like protein KIF15 (Kinesin-like protein 2) (hKLP2) (Kinesin-like protein 7) (Serologically defined breast cancer antigen NY-BR-62) | Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly. {ECO:0000250}. |
| Q9NW75 | GPATCH2 | S284 | ochoa | G patch domain-containing protein 2 | Enhances the ATPase activity of DHX15 in vitro. {ECO:0000269|PubMed:19432882}. |
| Q9NYF8 | BCLAF1 | S578 | ochoa | Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) | Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}. |
| Q9UEY8 | ADD3 | S589 | ochoa | Gamma-adducin (Adducin-like protein 70) | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping (PubMed:23836506). Binds to calmodulin (Probable). Involved in myogenic reactivity of the renal afferent arteriole (Af-art), renal interlobular arteries and middle cerebral artery (MCA) to increased perfusion pressure. Involved in regulation of potassium channels in the vascular smooth muscle cells (VSMCs) of the Af-art and MCA ex vivo. Involved in regulation of glomerular capillary pressure, glomerular filtration rate (GFR) and glomerular nephrin expression in response to hypertension. Involved in renal blood flow (RBF) autoregulation. Plays a role in podocyte structure and function. Regulates globular monomer actin (G-actin) and filamentous polymer actin (F-actin) ratios in the primary podocytes affecting actin cytoskeleton organization. Regulates expression of synaptopodin, RhoA, Rac1 and CDC42 in the renal cortex and the primary podocytes. Regulates expression of nephrin in the glomeruli and in the primary podocytes, expression of nephrin and podocinin in the renal cortex, and expression of focal adhesion proteins integrin alpha-3 and integrin beta-1 in the glomeruli. Involved in cell migration and cell adhesion of podocytes, and in podocyte foot process effacement. Regulates expression of profibrotics markers MMP2, MMP9, TGF beta-1, tubular tight junction protein E-cadherin, and mesenchymal markers vimentin and alpha-SMA (By similarity). Promotes the growth of neurites (By similarity). {ECO:0000250|UniProtKB:Q62847, ECO:0000250|UniProtKB:Q9QYB5, ECO:0000269|PubMed:23836506, ECO:0000305}. |
| Q9UHI6 | DDX20 | S549 | ochoa | Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.15) (EC 3.6.4.13) (Component of gems 3) (DEAD box protein 20) (DEAD box protein DP 103) (Gemin-3) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs). {ECO:0000269|PubMed:18984161}. |
| Q9UHI6 | DDX20 | S687 | ochoa | Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.15) (EC 3.6.4.13) (Component of gems 3) (DEAD box protein 20) (DEAD box protein DP 103) (Gemin-3) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs). {ECO:0000269|PubMed:18984161}. |
| Q9UHI6 | DDX20 | S695 | ochoa | Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.15) (EC 3.6.4.13) (Component of gems 3) (DEAD box protein 20) (DEAD box protein DP 103) (Gemin-3) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs). {ECO:0000269|PubMed:18984161}. |
| Q9UKY1 | ZHX1 | S543 | ochoa | Zinc fingers and homeoboxes protein 1 | Acts as a transcriptional repressor. Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins. {ECO:0000269|PubMed:12237128}. |
| Q9ULI0 | ATAD2B | S950 | ochoa | ATPase family AAA domain-containing protein 2B | None |
| Q9UPS6 | SETD1B | S994 | ochoa | Histone-lysine N-methyltransferase SETD1B (EC 2.1.1.364) (Lysine N-methyltransferase 2G) (SET domain-containing protein 1B) (hSET1B) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism (PubMed:17355966, PubMed:25561738). Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17355966, PubMed:25561738). Plays an essential role in regulating the transcriptional programming of multipotent hematopoietic progenitor cells and lymphoid lineage specification during hematopoiesis (By similarity). {ECO:0000250|UniProtKB:Q8CFT2, ECO:0000269|PubMed:17355966, ECO:0000269|PubMed:25561738}. |
| Q9UPZ3 | HPS5 | S585 | ochoa | BLOC-2 complex member HPS5 (Alpha-integrin-binding protein 63) (Hermansky-Pudlak syndrome 5 protein) (Ruby-eye protein 2 homolog) (Ru2) | May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. Regulates intracellular vesicular trafficking in fibroblasts. May be involved in the regulation of general functions of integrins. {ECO:0000269|PubMed:15296495, ECO:0000269|PubMed:17301833}. |
| Q9Y2G0 | EFR3B | S689 | ochoa | Protein EFR3 homolog B | Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:23229899, PubMed:25608530, PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (Probable). In the complex, EFR3B probably acts as the membrane-anchoring component (PubMed:23229899). Also involved in responsiveness to G-protein-coupled receptors; it is however unclear whether this role is direct or indirect (PubMed:25380825). {ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:25380825, ECO:0000269|PubMed:25608530, ECO:0000269|PubMed:26571211, ECO:0000305}. |
| Q9Y5U5 | TNFRSF18 | S217 | ochoa | Tumor necrosis factor receptor superfamily member 18 (Activation-inducible TNFR family receptor) (Glucocorticoid-induced TNFR-related protein) (CD antigen CD357) | Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway. |
| Q9Y666 | SLC12A7 | S108 | ochoa | Solute carrier family 12 member 7 (Electroneutral potassium-chloride cotransporter 4) (K-Cl cotransporter 4) | Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:10913127). May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity). {ECO:0000250, ECO:0000269|PubMed:10913127}. |
| Q9Y6J0 | CABIN1 | S20 | ochoa | Calcineurin-binding protein cabin-1 (Calcineurin inhibitor) (CAIN) | May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:9655484}. |
| Q9HAW4 | CLSPN | S1129 | EPSD|PSP | Claspin (hClaspin) | Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation (PubMed:12766152, PubMed:15190204, PubMed:15707391, PubMed:16123041). Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins (PubMed:12766152, PubMed:15096610, PubMed:15707391, PubMed:16123041). Also required to maintain normal rates of replication fork progression during unperturbed DNA replication. Binds directly to DNA, with particular affinity for branched or forked molecules and interacts with multiple protein components of the replisome such as the MCM2-7 complex and TIMELESS (PubMed:15226314, PubMed:34694004, PubMed:35585232). Important for initiation of DNA replication, recruits kinase CDC7 to phosphorylate MCM2-7 components (PubMed:27401717). {ECO:0000269|PubMed:12766152, ECO:0000269|PubMed:15096610, ECO:0000269|PubMed:15190204, ECO:0000269|PubMed:15226314, ECO:0000269|PubMed:15707391, ECO:0000269|PubMed:16123041, ECO:0000269|PubMed:27401717, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:35585232}. |
| P14625 | HSP90B1 | S523 | Sugiyama | Endoplasmin (EC 3.6.4.-) (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog) | ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport (PubMed:23572575, PubMed:39509507). Together with MESD, acts as a modulator of the Wnt pathway by promoting the folding of LRP6, a coreceptor of the canonical Wnt pathway (PubMed:23572575, PubMed:39509507). When associated with CNPY3, required for proper folding of Toll-like receptors (PubMed:11584270). Promotes folding and trafficking of TLR4 to the cell surface (PubMed:11584270). May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:11584270, ECO:0000269|PubMed:23572575, ECO:0000269|PubMed:32272059, ECO:0000269|PubMed:39509507}. |
| P61769 | B2M | S72 | Sugiyama | Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3] | Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553). {ECO:0000269|PubMed:25356553}. |
| P10721 | KIT | S715 | Sugiyama | Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117) | Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1. {ECO:0000269|PubMed:10397721, ECO:0000269|PubMed:12444928, ECO:0000269|PubMed:12511554, ECO:0000269|PubMed:12878163, ECO:0000269|PubMed:17904548, ECO:0000269|PubMed:19265199, ECO:0000269|PubMed:21135090, ECO:0000269|PubMed:21640708, ECO:0000269|PubMed:7520444, ECO:0000269|PubMed:9528781}. |
| Q02750 | MAP2K1 | S248 | SIGNOR | Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1) | Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (PubMed:29433126). Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis. {ECO:0000269|PubMed:14737111, ECO:0000269|PubMed:17101779, ECO:0000269|PubMed:29433126}. |
| Q14195 | DPYSL3 | S30 | Sugiyama | Dihydropyrimidinase-related protein 3 (DRP-3) (Collapsin response mediator protein 4) (CRMP-4) (Unc-33-like phosphoprotein 1) (ULIP-1) | Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity). {ECO:0000250}. |
| Q16555 | DPYSL2 | S30 | Sugiyama | Dihydropyrimidinase-related protein 2 (DRP-2) (Collapsin response mediator protein 2) (CRMP-2) (N2A3) (Unc-33-like phosphoprotein 2) (ULIP-2) | Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis. {ECO:0000269|PubMed:11477421, ECO:0000269|PubMed:15466863, ECO:0000269|PubMed:20801876}. |
| P46459 | NSF | S31 | Sugiyama | Vesicle-fusing ATPase (EC 3.6.4.6) (N-ethylmaleimide-sensitive fusion protein) (NEM-sensitive fusion protein) (Vesicular-fusion protein NSF) | Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling (By similarity). {ECO:0000250}. |
| P04150 | NR3C1 | S682 | PSP | Glucocorticoid receptor (GR) (Nuclear receptor subfamily 3 group C member 1) | Receptor for glucocorticoids (GC) (PubMed:27120390, PubMed:37478846). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors (PubMed:28139699). Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:25775514, ECO:0000269|PubMed:27120390, ECO:0000269|PubMed:28139699, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:9590696}.; FUNCTION: [Isoform Alpha]: Has transcriptional activation and repression activity (PubMed:11435610, PubMed:15769988, PubMed:15866175, PubMed:17635946, PubMed:19141540, PubMed:19248771, PubMed:20484466, PubMed:21664385, PubMed:23820903). Mediates glucocorticoid-induced apoptosis (PubMed:23303127). Promotes accurate chromosome segregation during mitosis (PubMed:25847991). May act as a tumor suppressor (PubMed:25847991). May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression (By similarity). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:11435610, ECO:0000269|PubMed:15769988, ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:17635946, ECO:0000269|PubMed:19141540, ECO:0000269|PubMed:19248771, ECO:0000269|PubMed:20484466, ECO:0000269|PubMed:21664385, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903, ECO:0000269|PubMed:25847991}.; FUNCTION: [Isoform Beta]: Acts as a dominant negative inhibitor of isoform Alpha (PubMed:20484466, PubMed:7769088, PubMed:8621628). Has intrinsic transcriptional activity independent of isoform Alpha when both isoforms are coexpressed (PubMed:19248771, PubMed:26711253). Loses this transcription modulator function on its own (PubMed:20484466). Has no hormone-binding activity (PubMed:8621628). May play a role in controlling glucose metabolism by maintaining insulin sensitivity (By similarity). Reduces hepatic gluconeogenesis through down-regulation of PEPCK in an isoform Alpha-dependent manner (PubMed:26711253). Directly regulates STAT1 expression in isoform Alpha-independent manner (PubMed:26711253). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:19248771, ECO:0000269|PubMed:20484466, ECO:0000269|PubMed:26711253, ECO:0000269|PubMed:7769088, ECO:0000269|PubMed:8621628}.; FUNCTION: [Isoform Alpha-2]: Has lower transcriptional activation activity than isoform Alpha. Exerts a dominant negative effect on isoform Alpha trans-repression mechanism (PubMed:20484466).; FUNCTION: [Isoform GR-P]: Increases activity of isoform Alpha. {ECO:0000269|PubMed:11358809}.; FUNCTION: [Isoform Alpha-B]: More effective than isoform Alpha in transcriptional activation, but not repression activity. {ECO:0000269|PubMed:11435610, ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform 10]: Has transcriptional activation activity. {ECO:0000269|PubMed:20484466}.; FUNCTION: [Isoform Alpha-C1]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-C2]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-C3]: Has highest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127). Mediates glucocorticoid-induced apoptosis (PubMed:23303127, PubMed:23820903). {ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903}.; FUNCTION: [Isoform Alpha-D1]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-D2]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-D3]: Has lowest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127). {ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903}. |
| Q9UBK8 | MTRR | S226 | Sugiyama | Methionine synthase reductase (MSR) (EC 1.16.1.8) (Aquacobalamin reductase) (AqCbl reductase) | Key enzyme in methionine and folate homeostasis responsible for the reactivation of methionine synthase (MTR/MS) activity by catalyzing the reductive methylation of MTR-bound cob(II)alamin (PubMed:17892308). Cobalamin (vitamin B12) forms a complex with MTR to serve as an intermediary in methyl transfer reactions that cycles between MTR-bound methylcob(III)alamin and MTR bound-cob(I)alamin forms, and occasional oxidative escape of the cob(I)alamin intermediate during the catalytic cycle leads to the inactive cob(II)alamin species (Probable). The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine (PubMed:27771510). Also necessary for the utilization of methyl groups from the folate cycle, thereby affecting transgenerational epigenetic inheritance (By similarity). Also acts as a molecular chaperone for methionine synthase by stabilizing apoMTR and incorporating methylcob(III)alamin into apoMTR to form the holoenzyme (PubMed:16769880). Also serves as an aquacob(III)alamin reductase by reducing aquacob(III)alamin to cob(II)alamin; this reduction leads to stimulation of the conversion of apoMTR and aquacob(III)alamin to MTR holoenzyme (PubMed:16769880). {ECO:0000250|UniProtKB:Q8C1A3, ECO:0000269|PubMed:16769880, ECO:0000269|PubMed:17892308, ECO:0000269|PubMed:27771510, ECO:0000305|PubMed:19243433}. |
| Q7KZF4 | SND1 | S720 | Sugiyama | Staphylococcal nuclease domain-containing protein 1 (EC 3.1.31.1) (100 kDa coactivator) (EBNA2 coactivator p100) (Tudor domain-containing protein 11) (p100 co-activator) | Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs (PubMed:18453631, PubMed:28546213). As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition (PubMed:28546213). Functions as a bridging factor between STAT6 and the basal transcription factor (PubMed:12234934). Plays a role in PIM1 regulation of MYB activity (PubMed:9809063). Functions as a transcriptional coactivator for STAT5 (By similarity). {ECO:0000250|UniProtKB:Q78PY7, ECO:0000269|PubMed:12234934, ECO:0000269|PubMed:18453631, ECO:0000269|PubMed:28546213, ECO:0000269|PubMed:9809063}.; FUNCTION: (Microbial infection) Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2 (EBNA2). {ECO:0000269|PubMed:7651391}.; FUNCTION: (Microbial infection) Promotes SARS-CoV-2 RNA synthesis by binding to negative-sense RNA and the viral protein nsp9. {ECO:0000269|PubMed:37794589}. |
| Q8WUF5 | PPP1R13L | S253 | Sugiyama | RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (NFkB-interacting protein 1) (PPP1R13B-like protein) | Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (PubMed:12524540). Is involved in NF-kappa-B dependent negative regulation of inflammatory response (PubMed:28069640). {ECO:0000269|PubMed:10336463, ECO:0000269|PubMed:12134007, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:15489900, ECO:0000269|PubMed:28069640}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-74160 | Gene expression (Transcription) | 1.904754e-11 | 10.720 |
| R-HSA-212436 | Generic Transcription Pathway | 5.181292e-10 | 9.286 |
| R-HSA-73857 | RNA Polymerase II Transcription | 8.939758e-10 | 9.049 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 7.372912e-08 | 7.132 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 6.102783e-08 | 7.214 |
| R-HSA-69620 | Cell Cycle Checkpoints | 1.576738e-07 | 6.802 |
| R-HSA-9637628 | Modulation by Mtb of host immune system | 2.175807e-07 | 6.662 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 3.800102e-07 | 6.420 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 3.800102e-07 | 6.420 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 4.722339e-07 | 6.326 |
| R-HSA-9706377 | FLT3 signaling by CBL mutants | 1.517131e-06 | 5.819 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 1.561255e-06 | 5.807 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 1.924864e-06 | 5.716 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 2.393882e-06 | 5.621 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 1.837833e-06 | 5.736 |
| R-HSA-9694493 | Maturation of protein E | 2.565300e-06 | 5.591 |
| R-HSA-9683683 | Maturation of protein E | 2.565300e-06 | 5.591 |
| R-HSA-1640170 | Cell Cycle | 3.268278e-06 | 5.486 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 3.458006e-06 | 5.461 |
| R-HSA-8948747 | Regulation of PTEN localization | 6.152852e-06 | 5.211 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 5.982736e-06 | 5.223 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 7.788706e-06 | 5.109 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 7.788706e-06 | 5.109 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 8.928906e-06 | 5.049 |
| R-HSA-3785653 | Myoclonic epilepsy of Lafora | 8.928906e-06 | 5.049 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 8.928906e-06 | 5.049 |
| R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 8.928906e-06 | 5.049 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 1.398798e-05 | 4.854 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 1.398798e-05 | 4.854 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 1.711224e-05 | 4.767 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 1.162518e-05 | 4.935 |
| R-HSA-937042 | IRAK2 mediated activation of TAK1 complex | 1.253444e-05 | 4.902 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 1.694116e-05 | 4.771 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 1.673901e-05 | 4.776 |
| R-HSA-5689877 | Josephin domain DUBs | 1.711224e-05 | 4.767 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 1.360922e-05 | 4.866 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 1.783462e-05 | 4.749 |
| R-HSA-2559585 | Oncogene Induced Senescence | 1.018944e-05 | 4.992 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 1.783462e-05 | 4.749 |
| R-HSA-9664873 | Pexophagy | 1.711224e-05 | 4.767 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 1.076798e-05 | 4.968 |
| R-HSA-9700206 | Signaling by ALK in cancer | 1.076798e-05 | 4.968 |
| R-HSA-9682385 | FLT3 signaling in disease | 1.162518e-05 | 4.935 |
| R-HSA-9645460 | Alpha-protein kinase 1 signaling pathway | 2.281394e-05 | 4.642 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 2.281394e-05 | 4.642 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 2.979952e-05 | 4.526 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 2.979952e-05 | 4.526 |
| R-HSA-209560 | NF-kB is activated and signals survival | 2.979952e-05 | 4.526 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 3.739271e-05 | 4.427 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 3.823681e-05 | 4.418 |
| R-HSA-69236 | G1 Phase | 3.342326e-05 | 4.476 |
| R-HSA-69231 | Cyclin D associated events in G1 | 3.342326e-05 | 4.476 |
| R-HSA-69206 | G1/S Transition | 3.795643e-05 | 4.421 |
| R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer | 3.823681e-05 | 4.418 |
| R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants | 3.823681e-05 | 4.418 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 3.823681e-05 | 4.418 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 3.823681e-05 | 4.418 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 3.823681e-05 | 4.418 |
| R-HSA-162909 | Host Interactions of HIV factors | 3.399601e-05 | 4.469 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 3.613781e-05 | 4.442 |
| R-HSA-162587 | HIV Life Cycle | 3.777548e-05 | 4.423 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 3.198385e-05 | 4.495 |
| R-HSA-983712 | Ion channel transport | 3.109671e-05 | 4.507 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 3.823681e-05 | 4.418 |
| R-HSA-69560 | Transcriptional activation of p53 responsive genes | 4.942779e-05 | 4.306 |
| R-HSA-69895 | Transcriptional activation of cell cycle inhibitor p21 | 4.942779e-05 | 4.306 |
| R-HSA-174490 | Membrane binding and targetting of GAG proteins | 4.830099e-05 | 4.316 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 4.975505e-05 | 4.303 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 6.017420e-05 | 4.221 |
| R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 6.017420e-05 | 4.221 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 6.017420e-05 | 4.221 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 6.496314e-05 | 4.187 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 7.404503e-05 | 4.131 |
| R-HSA-110312 | Translesion synthesis by REV1 | 7.404503e-05 | 4.131 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 7.404503e-05 | 4.131 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 7.404503e-05 | 4.131 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 7.404503e-05 | 4.131 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 7.404503e-05 | 4.131 |
| R-HSA-193639 | p75NTR signals via NF-kB | 7.404503e-05 | 4.131 |
| R-HSA-5656121 | Translesion synthesis by POLI | 9.010814e-05 | 4.045 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 9.010814e-05 | 4.045 |
| R-HSA-9708530 | Regulation of BACH1 activity | 9.010814e-05 | 4.045 |
| R-HSA-9706369 | Negative regulation of FLT3 | 9.010814e-05 | 4.045 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 9.431379e-05 | 4.025 |
| R-HSA-5655862 | Translesion synthesis by POLK | 1.085638e-04 | 3.964 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 1.060685e-04 | 3.974 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 1.085638e-04 | 3.964 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 1.085638e-04 | 3.964 |
| R-HSA-975110 | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | 1.085638e-04 | 3.964 |
| R-HSA-2559583 | Cellular Senescence | 1.082151e-04 | 3.966 |
| R-HSA-9679506 | SARS-CoV Infections | 1.147097e-04 | 3.940 |
| R-HSA-1980145 | Signaling by NOTCH2 | 1.189163e-04 | 3.925 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 1.189163e-04 | 3.925 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 1.223007e-04 | 3.913 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 1.250902e-04 | 3.903 |
| R-HSA-4641263 | Regulation of FZD by ubiquitination | 1.296175e-04 | 3.887 |
| R-HSA-3229121 | Glycogen storage diseases | 1.296175e-04 | 3.887 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.447214e-04 | 3.839 |
| R-HSA-450294 | MAP kinase activation | 1.556733e-04 | 3.808 |
| R-HSA-162906 | HIV Infection | 1.408571e-04 | 3.851 |
| R-HSA-2262752 | Cellular responses to stress | 1.343972e-04 | 3.872 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.445338e-04 | 3.840 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 1.681360e-04 | 3.774 |
| R-HSA-110320 | Translesion Synthesis by POLH | 1.803649e-04 | 3.744 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 1.803649e-04 | 3.744 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 1.803649e-04 | 3.744 |
| R-HSA-912631 | Regulation of signaling by CBL | 1.803649e-04 | 3.744 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 1.826145e-04 | 3.738 |
| R-HSA-936837 | Ion transport by P-type ATPases | 1.954227e-04 | 3.709 |
| R-HSA-69541 | Stabilization of p53 | 2.019770e-04 | 3.695 |
| R-HSA-9646399 | Aggrephagy | 2.228656e-04 | 3.652 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 2.440843e-04 | 3.612 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 2.228656e-04 | 3.652 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 2.440843e-04 | 3.612 |
| R-HSA-5633007 | Regulation of TP53 Activity | 2.284880e-04 | 3.641 |
| R-HSA-6807004 | Negative regulation of MET activity | 2.104923e-04 | 3.677 |
| R-HSA-68886 | M Phase | 2.364164e-04 | 3.626 |
| R-HSA-9636383 | Prevention of phagosomal-lysosomal fusion | 2.440843e-04 | 3.612 |
| R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 2.440843e-04 | 3.612 |
| R-HSA-9931295 | PD-L1(CD274) glycosylation and translocation to plasma membrane | 2.440843e-04 | 3.612 |
| R-HSA-3322077 | Glycogen synthesis | 2.104923e-04 | 3.677 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 2.453590e-04 | 3.610 |
| R-HSA-9607240 | FLT3 Signaling | 2.453590e-04 | 3.610 |
| R-HSA-2467813 | Separation of Sister Chromatids | 2.685407e-04 | 3.571 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 2.804585e-04 | 3.552 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 2.804585e-04 | 3.552 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 2.804585e-04 | 3.552 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 2.813670e-04 | 3.551 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 2.813670e-04 | 3.551 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 2.813670e-04 | 3.551 |
| R-HSA-175474 | Assembly Of The HIV Virion | 2.813670e-04 | 3.551 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 2.813670e-04 | 3.551 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 2.987358e-04 | 3.525 |
| R-HSA-448424 | Interleukin-17 signaling | 2.987358e-04 | 3.525 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 3.225694e-04 | 3.491 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 3.225694e-04 | 3.491 |
| R-HSA-9909396 | Circadian clock | 3.282125e-04 | 3.484 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 3.413332e-04 | 3.467 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 3.461741e-04 | 3.461 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 3.530123e-04 | 3.452 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 3.530123e-04 | 3.452 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 3.847682e-04 | 3.415 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 4.176630e-04 | 3.379 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 4.547048e-04 | 3.342 |
| R-HSA-68882 | Mitotic Anaphase | 4.162255e-04 | 3.381 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 4.300243e-04 | 3.367 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 4.269588e-04 | 3.370 |
| R-HSA-449147 | Signaling by Interleukins | 4.543343e-04 | 3.343 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 4.955227e-04 | 3.305 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 5.202318e-04 | 3.284 |
| R-HSA-5689901 | Metalloprotease DUBs | 5.312465e-04 | 3.275 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 5.312465e-04 | 3.275 |
| R-HSA-9637687 | Suppression of phagosomal maturation | 5.312465e-04 | 3.275 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 5.338148e-04 | 3.273 |
| R-HSA-9766229 | Degradation of CDH1 | 5.338148e-04 | 3.273 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 5.459125e-04 | 3.263 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 5.459125e-04 | 3.263 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 5.951819e-04 | 3.225 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 5.955683e-04 | 3.225 |
| R-HSA-901032 | ER Quality Control Compartment (ERQC) | 5.955683e-04 | 3.225 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 5.955683e-04 | 3.225 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 6.290609e-04 | 3.201 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 6.652309e-04 | 3.177 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 6.652309e-04 | 3.177 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 6.675641e-04 | 3.176 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 6.713210e-04 | 3.173 |
| R-HSA-68949 | Orc1 removal from chromatin | 6.713210e-04 | 3.173 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 7.404763e-04 | 3.130 |
| R-HSA-9615710 | Late endosomal microautophagy | 7.404763e-04 | 3.130 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 8.215474e-04 | 3.085 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 9.086873e-04 | 3.042 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 9.086873e-04 | 3.042 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 9.086873e-04 | 3.042 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 7.225662e-04 | 3.141 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 7.404763e-04 | 3.130 |
| R-HSA-9012852 | Signaling by NOTCH3 | 8.337640e-04 | 3.079 |
| R-HSA-162588 | Budding and maturation of HIV virion | 9.086873e-04 | 3.042 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 9.015001e-04 | 3.045 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 9.086873e-04 | 3.042 |
| R-HSA-182971 | EGFR downregulation | 9.086873e-04 | 3.042 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 9.006545e-04 | 3.045 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 9.006545e-04 | 3.045 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 7.219645e-04 | 3.141 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 7.404763e-04 | 3.130 |
| R-HSA-446652 | Interleukin-1 family signaling | 8.064720e-04 | 3.093 |
| R-HSA-5578775 | Ion homeostasis | 8.939180e-04 | 3.049 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 9.086873e-04 | 3.042 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 7.404763e-04 | 3.130 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 8.688758e-04 | 3.061 |
| R-HSA-9764561 | Regulation of CDH1 Function | 9.572449e-04 | 3.019 |
| R-HSA-3371556 | Cellular response to heat stress | 9.811998e-04 | 3.008 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 1.002140e-03 | 2.999 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 1.023544e-03 | 2.990 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 1.023544e-03 | 2.990 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 1.025775e-03 | 2.989 |
| R-HSA-194441 | Metabolism of non-coding RNA | 1.093831e-03 | 2.961 |
| R-HSA-191859 | snRNP Assembly | 1.093831e-03 | 2.961 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 1.093831e-03 | 2.961 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 1.102148e-03 | 2.958 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 1.102148e-03 | 2.958 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 1.102148e-03 | 2.958 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 1.167299e-03 | 2.933 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 1.167299e-03 | 2.933 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 1.167299e-03 | 2.933 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 1.167299e-03 | 2.933 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 1.167299e-03 | 2.933 |
| R-HSA-1227986 | Signaling by ERBB2 | 1.167299e-03 | 2.933 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 1.208956e-03 | 2.918 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 1.208956e-03 | 2.918 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 1.208956e-03 | 2.918 |
| R-HSA-69481 | G2/M Checkpoints | 1.308709e-03 | 2.883 |
| R-HSA-5696400 | Dual Incision in GG-NER | 1.322807e-03 | 2.879 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 1.322807e-03 | 2.879 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 1.322807e-03 | 2.879 |
| R-HSA-180746 | Nuclear import of Rev protein | 1.322807e-03 | 2.879 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 1.322807e-03 | 2.879 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 1.322807e-03 | 2.879 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 1.322807e-03 | 2.879 |
| R-HSA-5205647 | Mitophagy | 1.322807e-03 | 2.879 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 1.383595e-03 | 2.859 |
| R-HSA-8848021 | Signaling by PTK6 | 1.409677e-03 | 2.851 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 1.409677e-03 | 2.851 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 1.443942e-03 | 2.840 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 1.443942e-03 | 2.840 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 1.443942e-03 | 2.840 |
| R-HSA-169911 | Regulation of Apoptosis | 1.443942e-03 | 2.840 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 1.498152e-03 | 2.824 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 1.572605e-03 | 2.803 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 1.572605e-03 | 2.803 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 1.629212e-03 | 2.788 |
| R-HSA-8941333 | RUNX2 regulates genes involved in differentiation of myeloid cells | 2.210587e-03 | 2.655 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 2.006155e-03 | 2.698 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 2.167321e-03 | 2.664 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 2.488588e-03 | 2.604 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 2.415096e-03 | 2.617 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 2.337205e-03 | 2.631 |
| R-HSA-8866911 | TFAP2 (AP-2) family regulates transcription of cell cycle factors | 2.210587e-03 | 2.655 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 2.167321e-03 | 2.664 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 2.488588e-03 | 2.604 |
| R-HSA-4641258 | Degradation of DVL | 1.709035e-03 | 2.767 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 1.709035e-03 | 2.767 |
| R-HSA-4641257 | Degradation of AXIN | 1.709035e-03 | 2.767 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 1.709035e-03 | 2.767 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 1.709035e-03 | 2.767 |
| R-HSA-5693606 | DNA Double Strand Break Response | 1.788142e-03 | 2.748 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 2.006155e-03 | 2.698 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 2.236223e-03 | 2.650 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 2.236223e-03 | 2.650 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 2.167321e-03 | 2.664 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 2.337205e-03 | 2.631 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 2.337205e-03 | 2.631 |
| R-HSA-9020702 | Interleukin-1 signaling | 1.910081e-03 | 2.719 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 2.167321e-03 | 2.664 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 2.167321e-03 | 2.664 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 2.337205e-03 | 2.631 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 1.870438e-03 | 2.728 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 1.853472e-03 | 2.732 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 1.996176e-03 | 2.700 |
| R-HSA-5218859 | Regulated Necrosis | 1.893359e-03 | 2.723 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 2.006155e-03 | 2.698 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 2.188234e-03 | 2.660 |
| R-HSA-168255 | Influenza Infection | 2.092863e-03 | 2.679 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 1.709035e-03 | 2.767 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 1.709035e-03 | 2.767 |
| R-HSA-8982491 | Glycogen metabolism | 2.167321e-03 | 2.664 |
| R-HSA-913531 | Interferon Signaling | 2.442364e-03 | 2.612 |
| R-HSA-9648002 | RAS processing | 2.006155e-03 | 2.698 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 2.006155e-03 | 2.698 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 2.516039e-03 | 2.599 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 2.516039e-03 | 2.599 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 2.516039e-03 | 2.599 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 2.516039e-03 | 2.599 |
| R-HSA-9683701 | Translation of Structural Proteins | 2.516039e-03 | 2.599 |
| R-HSA-9013694 | Signaling by NOTCH4 | 2.622242e-03 | 2.581 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 2.704057e-03 | 2.568 |
| R-HSA-8852135 | Protein ubiquitination | 2.761027e-03 | 2.559 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 2.901488e-03 | 2.537 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 2.901488e-03 | 2.537 |
| R-HSA-5654743 | Signaling by FGFR4 | 2.901488e-03 | 2.537 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 2.901488e-03 | 2.537 |
| R-HSA-5689603 | UCH proteinases | 2.905055e-03 | 2.537 |
| R-HSA-1980143 | Signaling by NOTCH1 | 2.905055e-03 | 2.537 |
| R-HSA-8941284 | RUNX2 regulates chondrocyte maturation | 2.986522e-03 | 2.525 |
| R-HSA-168898 | Toll-like Receptor Cascades | 2.990586e-03 | 2.524 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 3.048015e-03 | 2.516 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 3.093455e-03 | 2.510 |
| R-HSA-69242 | S Phase | 3.117183e-03 | 2.506 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 3.117183e-03 | 2.506 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 3.209288e-03 | 2.494 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 3.325492e-03 | 2.478 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 3.325492e-03 | 2.478 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 3.325492e-03 | 2.478 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 3.325492e-03 | 2.478 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 3.325492e-03 | 2.478 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 3.325492e-03 | 2.478 |
| R-HSA-5654741 | Signaling by FGFR3 | 3.325492e-03 | 2.478 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 3.402696e-03 | 2.468 |
| R-HSA-5683057 | MAPK family signaling cascades | 3.427564e-03 | 2.465 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 3.552514e-03 | 2.449 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 3.552514e-03 | 2.449 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 3.552514e-03 | 2.449 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 3.552514e-03 | 2.449 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 3.552514e-03 | 2.449 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 3.565085e-03 | 2.448 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 3.661380e-03 | 2.436 |
| R-HSA-977225 | Amyloid fiber formation | 3.707765e-03 | 2.431 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 3.789843e-03 | 2.421 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 3.871838e-03 | 2.412 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 3.885606e-03 | 2.411 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 3.885606e-03 | 2.411 |
| R-HSA-5693538 | Homology Directed Repair | 4.256280e-03 | 2.371 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 4.259479e-03 | 2.371 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 4.259479e-03 | 2.371 |
| R-HSA-73893 | DNA Damage Bypass | 4.296290e-03 | 2.367 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 4.296290e-03 | 2.367 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 4.455734e-03 | 2.351 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 4.565834e-03 | 2.340 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 4.610349e-03 | 2.336 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 4.658349e-03 | 2.332 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 4.658349e-03 | 2.332 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 4.846537e-03 | 2.315 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 4.846537e-03 | 2.315 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 4.846537e-03 | 2.315 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 5.138606e-03 | 2.289 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 5.138606e-03 | 2.289 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 5.138606e-03 | 2.289 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 5.138606e-03 | 2.289 |
| R-HSA-9663891 | Selective autophagy | 5.305453e-03 | 2.275 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 5.442242e-03 | 2.264 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 5.442242e-03 | 2.264 |
| R-HSA-1236974 | ER-Phagosome pathway | 5.534606e-03 | 2.257 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 5.757646e-03 | 2.240 |
| R-HSA-202424 | Downstream TCR signaling | 5.770665e-03 | 2.239 |
| R-HSA-8949275 | RUNX3 Regulates Immune Response and Cell Migration | 5.960478e-03 | 2.225 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 6.085012e-03 | 2.216 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 6.424535e-03 | 2.192 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 6.424535e-03 | 2.192 |
| R-HSA-75893 | TNF signaling | 6.424535e-03 | 2.192 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 6.424535e-03 | 2.192 |
| R-HSA-177929 | Signaling by EGFR | 6.424535e-03 | 2.192 |
| R-HSA-5654736 | Signaling by FGFR1 | 6.424535e-03 | 2.192 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 6.769514e-03 | 2.169 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 6.769514e-03 | 2.169 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 6.776402e-03 | 2.169 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 6.776402e-03 | 2.169 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 6.786114e-03 | 2.168 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 7.129755e-03 | 2.147 |
| R-HSA-6782135 | Dual incision in TC-NER | 7.140800e-03 | 2.146 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 7.158842e-03 | 2.145 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 7.338050e-03 | 2.134 |
| R-HSA-9033241 | Peroxisomal protein import | 7.517911e-03 | 2.124 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 7.920571e-03 | 2.101 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 8.310982e-03 | 2.080 |
| R-HSA-9768777 | Regulation of NPAS4 gene transcription | 8.456666e-03 | 2.073 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 8.727288e-03 | 2.059 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 8.727288e-03 | 2.059 |
| R-HSA-6784531 | tRNA processing in the nucleus | 8.727288e-03 | 2.059 |
| R-HSA-9614085 | FOXO-mediated transcription | 8.853490e-03 | 2.053 |
| R-HSA-399719 | Trafficking of AMPA receptors | 8.964496e-03 | 2.047 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 9.180634e-03 | 2.037 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 9.851575e-03 | 2.006 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 9.859769e-03 | 2.006 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 1.005729e-02 | 1.998 |
| R-HSA-1234174 | Cellular response to hypoxia | 1.005729e-02 | 1.998 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 1.032713e-02 | 1.986 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 1.049012e-02 | 1.979 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 1.097936e-02 | 1.959 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 1.101311e-02 | 1.958 |
| R-HSA-9669937 | Drug resistance of KIT mutants | 1.130036e-02 | 1.947 |
| R-HSA-9669921 | KIT mutants bind TKIs | 1.130036e-02 | 1.947 |
| R-HSA-9669914 | Dasatinib-resistant KIT mutants | 1.130036e-02 | 1.947 |
| R-HSA-9669917 | Imatinib-resistant KIT mutants | 1.130036e-02 | 1.947 |
| R-HSA-9669934 | Sunitinib-resistant KIT mutants | 1.130036e-02 | 1.947 |
| R-HSA-9669936 | Sorafenib-resistant KIT mutants | 1.130036e-02 | 1.947 |
| R-HSA-9661070 | Defective translocation of RB1 mutants to the nucleus | 1.130036e-02 | 1.947 |
| R-HSA-9669926 | Nilotinib-resistant KIT mutants | 1.130036e-02 | 1.947 |
| R-HSA-9669929 | Regorafenib-resistant KIT mutants | 1.130036e-02 | 1.947 |
| R-HSA-9669924 | Masitinib-resistant KIT mutants | 1.130036e-02 | 1.947 |
| R-HSA-9645722 | Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function | 2.247371e-02 | 1.648 |
| R-HSA-5545483 | Defective Mismatch Repair Associated With MLH1 | 2.247371e-02 | 1.648 |
| R-HSA-5632987 | Defective Mismatch Repair Associated With PMS2 | 2.247371e-02 | 1.648 |
| R-HSA-8941332 | RUNX2 regulates genes involved in cell migration | 1.134123e-02 | 1.945 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 1.635594e-02 | 1.786 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 1.635594e-02 | 1.786 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 1.180350e-02 | 1.928 |
| R-HSA-8941326 | RUNX2 regulates bone development | 1.339511e-02 | 1.873 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 1.541483e-02 | 1.812 |
| R-HSA-5696398 | Nucleotide Excision Repair | 1.132011e-02 | 1.946 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 2.229181e-02 | 1.652 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 1.887220e-02 | 1.724 |
| R-HSA-399956 | CRMPs in Sema3A signaling | 1.820203e-02 | 1.740 |
| R-HSA-5673000 | RAF activation | 1.180350e-02 | 1.928 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 1.292150e-02 | 1.889 |
| R-HSA-73894 | DNA Repair | 1.220616e-02 | 1.913 |
| R-HSA-202403 | TCR signaling | 1.334457e-02 | 1.875 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 1.971635e-02 | 1.705 |
| R-HSA-69239 | Synthesis of DNA | 1.210281e-02 | 1.917 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 1.250762e-02 | 1.903 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 1.258482e-02 | 1.900 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 1.459565e-02 | 1.836 |
| R-HSA-8953854 | Metabolism of RNA | 1.858134e-02 | 1.731 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 1.292334e-02 | 1.889 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 1.365337e-02 | 1.865 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 1.292150e-02 | 1.889 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 1.422549e-02 | 1.847 |
| R-HSA-8877330 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | 1.635594e-02 | 1.786 |
| R-HSA-5632684 | Hedgehog 'on' state | 1.309611e-02 | 1.883 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 1.255359e-02 | 1.901 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 2.153274e-02 | 1.667 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 1.255359e-02 | 1.901 |
| R-HSA-5619084 | ABC transporter disorders | 1.731333e-02 | 1.762 |
| R-HSA-68875 | Mitotic Prophase | 1.916671e-02 | 1.717 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 1.820203e-02 | 1.740 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 1.170701e-02 | 1.932 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 1.635594e-02 | 1.786 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 1.365337e-02 | 1.865 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 1.792380e-02 | 1.747 |
| R-HSA-5357801 | Programmed Cell Death | 1.511526e-02 | 1.821 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 1.206487e-02 | 1.918 |
| R-HSA-5654738 | Signaling by FGFR2 | 1.865657e-02 | 1.729 |
| R-HSA-418990 | Adherens junctions interactions | 1.985533e-02 | 1.702 |
| R-HSA-2672351 | Stimuli-sensing channels | 1.250762e-02 | 1.903 |
| R-HSA-6806834 | Signaling by MET | 1.865657e-02 | 1.729 |
| R-HSA-9679191 | Potential therapeutics for SARS | 1.300168e-02 | 1.886 |
| R-HSA-211000 | Gene Silencing by RNA | 1.210281e-02 | 1.917 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 1.192333e-02 | 1.924 |
| R-HSA-4086400 | PCP/CE pathway | 1.731333e-02 | 1.762 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 1.971635e-02 | 1.705 |
| R-HSA-1236394 | Signaling by ERBB4 | 1.481261e-02 | 1.829 |
| R-HSA-109581 | Apoptosis | 1.762862e-02 | 1.754 |
| R-HSA-917937 | Iron uptake and transport | 1.541483e-02 | 1.812 |
| R-HSA-5663084 | Diseases of carbohydrate metabolism | 1.422549e-02 | 1.847 |
| R-HSA-9694635 | Translation of Structural Proteins | 1.666508e-02 | 1.778 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 2.306705e-02 | 1.637 |
| R-HSA-774815 | Nucleosome assembly | 2.311527e-02 | 1.636 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 2.311527e-02 | 1.636 |
| R-HSA-5689880 | Ub-specific processing proteases | 2.327892e-02 | 1.633 |
| R-HSA-9702518 | STAT5 activation downstream of FLT3 ITD mutants | 2.423387e-02 | 1.616 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 2.425030e-02 | 1.615 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 2.425030e-02 | 1.615 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 2.425030e-02 | 1.615 |
| R-HSA-6802949 | Signaling by RAS mutants | 2.425030e-02 | 1.615 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 2.432621e-02 | 1.614 |
| R-HSA-70268 | Pyruvate metabolism | 2.466633e-02 | 1.608 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 2.640211e-02 | 1.578 |
| R-HSA-5210891 | Uptake and function of anthrax toxins | 2.640211e-02 | 1.578 |
| R-HSA-5576891 | Cardiac conduction | 2.712973e-02 | 1.567 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 2.985891e-02 | 1.525 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 2.985891e-02 | 1.525 |
| R-HSA-3371571 | HSF1-dependent transactivation | 3.037004e-02 | 1.518 |
| R-HSA-69275 | G2/M Transition | 3.065161e-02 | 1.514 |
| R-HSA-9834899 | Specification of the neural plate border | 3.096300e-02 | 1.509 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 3.168255e-02 | 1.499 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 3.190700e-02 | 1.496 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 3.217621e-02 | 1.492 |
| R-HSA-9948299 | Ribosome-associated quality control | 3.294184e-02 | 1.482 |
| R-HSA-9680187 | Signaling by extracellular domain mutants of KIT | 3.352148e-02 | 1.475 |
| R-HSA-9669935 | Signaling by juxtamembrane domain KIT mutants | 3.352148e-02 | 1.475 |
| R-HSA-9669933 | Signaling by kinase domain mutants of KIT | 3.352148e-02 | 1.475 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 3.365352e-02 | 1.473 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 3.439552e-02 | 1.463 |
| R-HSA-68877 | Mitotic Prometaphase | 3.519093e-02 | 1.454 |
| R-HSA-1632852 | Macroautophagy | 3.530664e-02 | 1.452 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 3.565155e-02 | 1.448 |
| R-HSA-421270 | Cell-cell junction organization | 3.634541e-02 | 1.440 |
| R-HSA-190236 | Signaling by FGFR | 3.667583e-02 | 1.436 |
| R-HSA-3214847 | HATs acetylate histones | 3.771697e-02 | 1.423 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 3.771697e-02 | 1.423 |
| R-HSA-9824446 | Viral Infection Pathways | 3.799497e-02 | 1.420 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 3.833643e-02 | 1.416 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 3.833643e-02 | 1.416 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 3.833643e-02 | 1.416 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 3.833643e-02 | 1.416 |
| R-HSA-382556 | ABC-family proteins mediated transport | 3.877499e-02 | 1.411 |
| R-HSA-5610787 | Hedgehog 'off' state | 3.877499e-02 | 1.411 |
| R-HSA-70171 | Glycolysis | 3.877499e-02 | 1.411 |
| R-HSA-5688426 | Deubiquitination | 3.881789e-02 | 1.411 |
| R-HSA-389948 | Co-inhibition by PD-1 | 4.014343e-02 | 1.396 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 4.317597e-02 | 1.365 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 4.358506e-02 | 1.361 |
| R-HSA-9833110 | RSV-host interactions | 4.431845e-02 | 1.353 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 4.444506e-02 | 1.352 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 4.444506e-02 | 1.352 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 4.444506e-02 | 1.352 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 4.444506e-02 | 1.352 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 4.444506e-02 | 1.352 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 4.444506e-02 | 1.352 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 4.444506e-02 | 1.352 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 4.444506e-02 | 1.352 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 4.444506e-02 | 1.352 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 4.444506e-02 | 1.352 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 4.444506e-02 | 1.352 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 4.486074e-02 | 1.348 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 4.579882e-02 | 1.339 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 4.630389e-02 | 1.334 |
| R-HSA-69306 | DNA Replication | 4.674857e-02 | 1.330 |
| R-HSA-373755 | Semaphorin interactions | 4.803183e-02 | 1.318 |
| R-HSA-9620244 | Long-term potentiation | 4.908341e-02 | 1.309 |
| R-HSA-9612973 | Autophagy | 4.966792e-02 | 1.304 |
| R-HSA-397014 | Muscle contraction | 5.046635e-02 | 1.297 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 5.192191e-02 | 1.285 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 5.192191e-02 | 1.285 |
| R-HSA-9006936 | Signaling by TGFB family members | 5.372424e-02 | 1.270 |
| R-HSA-1483249 | Inositol phosphate metabolism | 5.406446e-02 | 1.267 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 5.481773e-02 | 1.261 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 5.481773e-02 | 1.261 |
| R-HSA-446728 | Cell junction organization | 5.516960e-02 | 1.258 |
| R-HSA-5423599 | Diseases of Mismatch Repair (MMR) | 5.524584e-02 | 1.258 |
| R-HSA-1266738 | Developmental Biology | 5.795610e-02 | 1.237 |
| R-HSA-8951664 | Neddylation | 5.848674e-02 | 1.233 |
| R-HSA-422475 | Axon guidance | 5.971252e-02 | 1.224 |
| R-HSA-909733 | Interferon alpha/beta signaling | 6.069915e-02 | 1.217 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 6.204654e-02 | 1.207 |
| R-HSA-373760 | L1CAM interactions | 6.207574e-02 | 1.207 |
| R-HSA-70326 | Glucose metabolism | 6.346876e-02 | 1.197 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 6.383282e-02 | 1.195 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 6.383282e-02 | 1.195 |
| R-HSA-9008059 | Interleukin-37 signaling | 6.383282e-02 | 1.195 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 6.487817e-02 | 1.188 |
| R-HSA-8952158 | RUNX3 regulates BCL2L11 (BIM) transcription | 6.592520e-02 | 1.181 |
| R-HSA-69200 | Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 ... | 6.592520e-02 | 1.181 |
| R-HSA-9652169 | Signaling by MAP2K mutants | 6.592520e-02 | 1.181 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 6.701699e-02 | 1.174 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 6.820055e-02 | 1.166 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 6.920414e-02 | 1.160 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 7.010013e-02 | 1.154 |
| R-HSA-3247509 | Chromatin modifying enzymes | 7.134818e-02 | 1.147 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 7.330638e-02 | 1.135 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 7.330638e-02 | 1.135 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 7.330638e-02 | 1.135 |
| R-HSA-9733709 | Cardiogenesis | 7.330638e-02 | 1.135 |
| R-HSA-74713 | IRS activation | 7.648449e-02 | 1.116 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 7.648449e-02 | 1.116 |
| R-HSA-9931529 | Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK | 7.648449e-02 | 1.116 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 7.648449e-02 | 1.116 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 7.648449e-02 | 1.116 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 7.985671e-02 | 1.098 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 7.985671e-02 | 1.098 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 7.985671e-02 | 1.098 |
| R-HSA-9675108 | Nervous system development | 8.440235e-02 | 1.074 |
| R-HSA-3371511 | HSF1 activation | 8.658131e-02 | 1.063 |
| R-HSA-111933 | Calmodulin induced events | 8.658131e-02 | 1.063 |
| R-HSA-111997 | CaM pathway | 8.658131e-02 | 1.063 |
| R-HSA-69205 | G1/S-Specific Transcription | 8.658131e-02 | 1.063 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 8.692507e-02 | 1.061 |
| R-HSA-3359467 | Defective MTRR causes HMAE | 8.692507e-02 | 1.061 |
| R-HSA-163358 | PKA-mediated phosphorylation of key metabolic factors | 8.692507e-02 | 1.061 |
| R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 8.692507e-02 | 1.061 |
| R-HSA-4839726 | Chromatin organization | 8.805808e-02 | 1.055 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 9.000549e-02 | 1.046 |
| R-HSA-1500931 | Cell-Cell communication | 9.044528e-02 | 1.044 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 9.653207e-02 | 1.015 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 9.697092e-02 | 1.013 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 9.712965e-02 | 1.013 |
| R-HSA-3359469 | Defective MTR causes HMAG | 9.724824e-02 | 1.012 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 9.814060e-02 | 1.008 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.859244e-02 | 1.006 |
| R-HSA-156902 | Peptide chain elongation | 9.950693e-02 | 1.002 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 1.005096e-01 | 0.998 |
| R-HSA-3371568 | Attenuation phase | 1.005096e-01 | 0.998 |
| R-HSA-5358351 | Signaling by Hedgehog | 1.016583e-01 | 0.993 |
| R-HSA-6807070 | PTEN Regulation | 1.034388e-01 | 0.985 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 1.040838e-01 | 0.983 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 1.064697e-01 | 0.973 |
| R-HSA-163767 | PP2A-mediated dephosphorylation of key metabolic factors | 1.074553e-01 | 0.969 |
| R-HSA-8849473 | PTK6 Expression | 1.074553e-01 | 0.969 |
| R-HSA-426117 | Cation-coupled Chloride cotransporters | 1.074553e-01 | 0.969 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 1.074553e-01 | 0.969 |
| R-HSA-5674135 | MAP2K and MAPK activation | 1.076923e-01 | 0.968 |
| R-HSA-167161 | HIV Transcription Initiation | 1.076923e-01 | 0.968 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 1.076923e-01 | 0.968 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 1.076923e-01 | 0.968 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 1.076923e-01 | 0.968 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 1.076923e-01 | 0.968 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 1.088322e-01 | 0.963 |
| R-HSA-376176 | Signaling by ROBO receptors | 1.105067e-01 | 0.957 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 1.112149e-01 | 0.954 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 1.113340e-01 | 0.953 |
| R-HSA-111996 | Ca-dependent events | 1.113340e-01 | 0.953 |
| R-HSA-9711123 | Cellular response to chemical stress | 1.120345e-01 | 0.951 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 1.125539e-01 | 0.949 |
| R-HSA-72172 | mRNA Splicing | 1.135956e-01 | 0.945 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 1.144186e-01 | 0.942 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 1.150076e-01 | 0.939 |
| R-HSA-8854214 | TBC/RABGAPs | 1.150076e-01 | 0.939 |
| R-HSA-164940 | Nef mediated downregulation of MHC class I complex cell surface expression | 1.175476e-01 | 0.930 |
| R-HSA-425986 | Sodium/Proton exchangers | 1.175476e-01 | 0.930 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 1.209431e-01 | 0.917 |
| R-HSA-72764 | Eukaryotic Translation Termination | 1.209431e-01 | 0.917 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 1.224458e-01 | 0.912 |
| R-HSA-1489509 | DAG and IP3 signaling | 1.224458e-01 | 0.912 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 1.224458e-01 | 0.912 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 1.234229e-01 | 0.909 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 1.258895e-01 | 0.900 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 1.262082e-01 | 0.899 |
| R-HSA-176974 | Unwinding of DNA | 1.275265e-01 | 0.894 |
| R-HSA-198693 | AKT phosphorylates targets in the nucleus | 1.275265e-01 | 0.894 |
| R-HSA-163680 | AMPK inhibits chREBP transcriptional activation activity | 1.275265e-01 | 0.894 |
| R-HSA-448706 | Interleukin-1 processing | 1.275265e-01 | 0.894 |
| R-HSA-9834752 | Respiratory syncytial virus genome replication | 1.275265e-01 | 0.894 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 1.299979e-01 | 0.886 |
| R-HSA-9609507 | Protein localization | 1.318010e-01 | 0.880 |
| R-HSA-73887 | Death Receptor Signaling | 1.337968e-01 | 0.874 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 1.337968e-01 | 0.874 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 1.338138e-01 | 0.873 |
| R-HSA-2408557 | Selenocysteine synthesis | 1.360937e-01 | 0.866 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 1.360937e-01 | 0.866 |
| R-HSA-110056 | MAPK3 (ERK1) activation | 1.373930e-01 | 0.862 |
| R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 1.373930e-01 | 0.862 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 1.373930e-01 | 0.862 |
| R-HSA-74749 | Signal attenuation | 1.373930e-01 | 0.862 |
| R-HSA-9610379 | HCMV Late Events | 1.398582e-01 | 0.854 |
| R-HSA-192823 | Viral mRNA Translation | 1.412833e-01 | 0.850 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 1.419029e-01 | 0.848 |
| R-HSA-199991 | Membrane Trafficking | 1.421836e-01 | 0.847 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 1.439028e-01 | 0.842 |
| R-HSA-877300 | Interferon gamma signaling | 1.439596e-01 | 0.842 |
| R-HSA-9864848 | Complex IV assembly | 1.454087e-01 | 0.837 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 1.471486e-01 | 0.832 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 1.471486e-01 | 0.832 |
| R-HSA-192905 | vRNP Assembly | 1.471486e-01 | 0.832 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 1.471486e-01 | 0.832 |
| R-HSA-75205 | Dissolution of Fibrin Clot | 1.471486e-01 | 0.832 |
| R-HSA-5653656 | Vesicle-mediated transport | 1.512862e-01 | 0.820 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 1.545392e-01 | 0.811 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 1.567945e-01 | 0.805 |
| R-HSA-1236977 | Endosomal/Vacuolar pathway | 1.567945e-01 | 0.805 |
| R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 1.567945e-01 | 0.805 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 1.567945e-01 | 0.805 |
| R-HSA-72649 | Translation initiation complex formation | 1.572025e-01 | 0.804 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 1.572363e-01 | 0.803 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 1.572363e-01 | 0.803 |
| R-HSA-5619102 | SLC transporter disorders | 1.608253e-01 | 0.794 |
| R-HSA-1643685 | Disease | 1.630260e-01 | 0.788 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 1.651627e-01 | 0.782 |
| R-HSA-5663205 | Infectious disease | 1.652707e-01 | 0.782 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 1.663319e-01 | 0.779 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 1.663319e-01 | 0.779 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 1.663319e-01 | 0.779 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 1.663319e-01 | 0.779 |
| R-HSA-1679131 | Trafficking and processing of endosomal TLR | 1.663319e-01 | 0.779 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 1.663319e-01 | 0.779 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 1.681680e-01 | 0.774 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 1.681680e-01 | 0.774 |
| R-HSA-382551 | Transport of small molecules | 1.687571e-01 | 0.773 |
| R-HSA-72306 | tRNA processing | 1.695193e-01 | 0.771 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 1.731923e-01 | 0.761 |
| R-HSA-170968 | Frs2-mediated activation | 1.757619e-01 | 0.755 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 1.757619e-01 | 0.755 |
| R-HSA-9682706 | Replication of the SARS-CoV-1 genome | 1.757619e-01 | 0.755 |
| R-HSA-157118 | Signaling by NOTCH | 1.757714e-01 | 0.755 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 1.765776e-01 | 0.753 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 1.849625e-01 | 0.733 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 1.849625e-01 | 0.733 |
| R-HSA-1433559 | Regulation of KIT signaling | 1.850859e-01 | 0.733 |
| R-HSA-9679514 | SARS-CoV-1 Genome Replication and Transcription | 1.850859e-01 | 0.733 |
| R-HSA-112043 | PLC beta mediated events | 1.853515e-01 | 0.732 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 1.869805e-01 | 0.728 |
| R-HSA-9707616 | Heme signaling | 1.894318e-01 | 0.723 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 1.943050e-01 | 0.712 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 1.943050e-01 | 0.712 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 1.943050e-01 | 0.712 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 1.988496e-01 | 0.701 |
| R-HSA-73886 | Chromosome Maintenance | 1.992817e-01 | 0.701 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 2.017429e-01 | 0.695 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 2.034203e-01 | 0.692 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 2.034203e-01 | 0.692 |
| R-HSA-169893 | Prolonged ERK activation events | 2.034203e-01 | 0.692 |
| R-HSA-112040 | G-protein mediated events | 2.100013e-01 | 0.678 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 2.124331e-01 | 0.673 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 2.141435e-01 | 0.669 |
| R-HSA-167172 | Transcription of the HIV genome | 2.141435e-01 | 0.669 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 2.182934e-01 | 0.661 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 2.213444e-01 | 0.655 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 2.213444e-01 | 0.655 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 2.213444e-01 | 0.655 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 2.213444e-01 | 0.655 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 2.213444e-01 | 0.655 |
| R-HSA-9694686 | Replication of the SARS-CoV-2 genome | 2.213444e-01 | 0.655 |
| R-HSA-8978934 | Metabolism of cofactors | 2.266136e-01 | 0.645 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 2.294470e-01 | 0.639 |
| R-HSA-9609690 | HCMV Early Events | 2.295856e-01 | 0.639 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 2.301555e-01 | 0.638 |
| R-HSA-5358508 | Mismatch Repair | 2.301555e-01 | 0.638 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 2.301555e-01 | 0.638 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 2.301555e-01 | 0.638 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 2.301555e-01 | 0.638 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 2.301555e-01 | 0.638 |
| R-HSA-111471 | Apoptotic factor-mediated response | 2.301555e-01 | 0.638 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 2.307826e-01 | 0.637 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 2.388674e-01 | 0.622 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 2.388674e-01 | 0.622 |
| R-HSA-844456 | The NLRP3 inflammasome | 2.388674e-01 | 0.622 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 2.388674e-01 | 0.622 |
| R-HSA-9694682 | SARS-CoV-2 Genome Replication and Transcription | 2.388674e-01 | 0.622 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 2.391350e-01 | 0.621 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 2.408580e-01 | 0.618 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 2.466090e-01 | 0.608 |
| R-HSA-445144 | Signal transduction by L1 | 2.474812e-01 | 0.606 |
| R-HSA-1181150 | Signaling by NODAL | 2.474812e-01 | 0.606 |
| R-HSA-9020591 | Interleukin-12 signaling | 2.475024e-01 | 0.606 |
| R-HSA-191273 | Cholesterol biosynthesis | 2.558800e-01 | 0.592 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 2.559981e-01 | 0.592 |
| R-HSA-140837 | Intrinsic Pathway of Fibrin Clot Formation | 2.559981e-01 | 0.592 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 2.607714e-01 | 0.584 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 2.618185e-01 | 0.582 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 2.642631e-01 | 0.578 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 2.644191e-01 | 0.578 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 2.644191e-01 | 0.578 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 2.713839e-01 | 0.566 |
| R-HSA-9669938 | Signaling by KIT in disease | 2.727453e-01 | 0.564 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 2.727453e-01 | 0.564 |
| R-HSA-350054 | Notch-HLH transcription pathway | 2.727453e-01 | 0.564 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 2.727453e-01 | 0.564 |
| R-HSA-6807062 | Cholesterol biosynthesis via lathosterol | 2.727453e-01 | 0.564 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 2.727453e-01 | 0.564 |
| R-HSA-597592 | Post-translational protein modification | 2.731580e-01 | 0.564 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 2.809778e-01 | 0.551 |
| R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse | 2.891176e-01 | 0.539 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 2.891176e-01 | 0.539 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 2.891176e-01 | 0.539 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 2.891176e-01 | 0.539 |
| R-HSA-8863678 | Neurodegenerative Diseases | 2.891176e-01 | 0.539 |
| R-HSA-429947 | Deadenylation of mRNA | 2.891176e-01 | 0.539 |
| R-HSA-5669034 | TNFs bind their physiological receptors | 2.891176e-01 | 0.539 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 2.893902e-01 | 0.539 |
| R-HSA-9758941 | Gastrulation | 2.955512e-01 | 0.529 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 2.971657e-01 | 0.527 |
| R-HSA-3296469 | Defects in cobalamin (B12) metabolism | 2.971657e-01 | 0.527 |
| R-HSA-9839394 | TGFBR3 expression | 2.971657e-01 | 0.527 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 2.971657e-01 | 0.527 |
| R-HSA-438064 | Post NMDA receptor activation events | 2.977643e-01 | 0.526 |
| R-HSA-447115 | Interleukin-12 family signaling | 2.977643e-01 | 0.526 |
| R-HSA-9645723 | Diseases of programmed cell death | 3.019402e-01 | 0.520 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 3.051232e-01 | 0.516 |
| R-HSA-525793 | Myogenesis | 3.051232e-01 | 0.516 |
| R-HSA-3295583 | TRP channels | 3.051232e-01 | 0.516 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 3.051232e-01 | 0.516 |
| R-HSA-9845614 | Sphingolipid catabolism | 3.051232e-01 | 0.516 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 3.118107e-01 | 0.506 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 3.129911e-01 | 0.504 |
| R-HSA-9759218 | Cobalamin (Cbl) metabolism | 3.129911e-01 | 0.504 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 3.129911e-01 | 0.504 |
| R-HSA-264876 | Insulin processing | 3.129911e-01 | 0.504 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 3.144411e-01 | 0.502 |
| R-HSA-77387 | Insulin receptor recycling | 3.207704e-01 | 0.494 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 3.207704e-01 | 0.494 |
| R-HSA-622312 | Inflammasomes | 3.207704e-01 | 0.494 |
| R-HSA-9711097 | Cellular response to starvation | 3.233547e-01 | 0.490 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 3.284621e-01 | 0.484 |
| R-HSA-8939211 | ESR-mediated signaling | 3.348451e-01 | 0.475 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 3.360672e-01 | 0.474 |
| R-HSA-68962 | Activation of the pre-replicative complex | 3.360672e-01 | 0.474 |
| R-HSA-2424491 | DAP12 signaling | 3.360672e-01 | 0.474 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 3.360672e-01 | 0.474 |
| R-HSA-2408522 | Selenoamino acid metabolism | 3.419085e-01 | 0.466 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 3.434010e-01 | 0.464 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 3.510152e-01 | 0.455 |
| R-HSA-69190 | DNA strand elongation | 3.510213e-01 | 0.455 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 3.510213e-01 | 0.455 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 3.516079e-01 | 0.454 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 3.583722e-01 | 0.446 |
| R-HSA-168256 | Immune System | 3.586456e-01 | 0.445 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 3.635077e-01 | 0.439 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 3.656403e-01 | 0.437 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 3.656403e-01 | 0.437 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 3.656403e-01 | 0.437 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 3.679137e-01 | 0.434 |
| R-HSA-9609646 | HCMV Infection | 3.682072e-01 | 0.434 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 3.728266e-01 | 0.428 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 3.728266e-01 | 0.428 |
| R-HSA-203615 | eNOS activation | 3.728266e-01 | 0.428 |
| R-HSA-111885 | Opioid Signalling | 3.760078e-01 | 0.425 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 3.799319e-01 | 0.420 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 3.799319e-01 | 0.420 |
| R-HSA-3296482 | Defects in vitamin and cofactor metabolism | 3.799319e-01 | 0.420 |
| R-HSA-187687 | Signalling to ERKs | 3.799319e-01 | 0.420 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 3.869571e-01 | 0.412 |
| R-HSA-196757 | Metabolism of folate and pterines | 3.939031e-01 | 0.405 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 3.960527e-01 | 0.402 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 4.007709e-01 | 0.397 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 4.007709e-01 | 0.397 |
| R-HSA-9734767 | Developmental Cell Lineages | 4.014870e-01 | 0.396 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 4.075613e-01 | 0.390 |
| R-HSA-202433 | Generation of second messenger molecules | 4.142751e-01 | 0.383 |
| R-HSA-5260271 | Diseases of Immune System | 4.142751e-01 | 0.383 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 4.142751e-01 | 0.383 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 4.184108e-01 | 0.378 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 4.197116e-01 | 0.377 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 4.209133e-01 | 0.376 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 4.209133e-01 | 0.376 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 4.209133e-01 | 0.376 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 4.236097e-01 | 0.373 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 4.274766e-01 | 0.369 |
| R-HSA-6811438 | Intra-Golgi traffic | 4.274766e-01 | 0.369 |
| R-HSA-3000480 | Scavenging by Class A Receptors | 4.274766e-01 | 0.369 |
| R-HSA-9007101 | Rab regulation of trafficking | 4.390654e-01 | 0.357 |
| R-HSA-1433557 | Signaling by SCF-KIT | 4.403822e-01 | 0.356 |
| R-HSA-2172127 | DAP12 interactions | 4.467260e-01 | 0.350 |
| R-HSA-196741 | Cobalamin (Cbl, vitamin B12) transport and metabolism | 4.467260e-01 | 0.350 |
| R-HSA-156581 | Methylation | 4.467260e-01 | 0.350 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 4.529984e-01 | 0.344 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 4.541680e-01 | 0.343 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 4.592000e-01 | 0.338 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 4.592000e-01 | 0.338 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 4.592000e-01 | 0.338 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 4.592000e-01 | 0.338 |
| R-HSA-9675135 | Diseases of DNA repair | 4.592000e-01 | 0.338 |
| R-HSA-9839373 | Signaling by TGFBR3 | 4.592000e-01 | 0.338 |
| R-HSA-75153 | Apoptotic execution phase | 4.592000e-01 | 0.338 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 4.600423e-01 | 0.337 |
| R-HSA-2132295 | MHC class II antigen presentation | 4.618204e-01 | 0.336 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 4.618204e-01 | 0.336 |
| R-HSA-437239 | Recycling pathway of L1 | 4.653317e-01 | 0.332 |
| R-HSA-5620924 | Intraflagellar transport | 4.713942e-01 | 0.327 |
| R-HSA-9031628 | NGF-stimulated transcription | 4.713942e-01 | 0.327 |
| R-HSA-425410 | Metal ion SLC transporters | 4.713942e-01 | 0.327 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 4.713942e-01 | 0.327 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 4.840312e-01 | 0.315 |
| R-HSA-195721 | Signaling by WNT | 4.890228e-01 | 0.311 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 4.913089e-01 | 0.309 |
| R-HSA-72187 | mRNA 3'-end processing | 4.949683e-01 | 0.305 |
| R-HSA-445355 | Smooth Muscle Contraction | 5.006965e-01 | 0.300 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 5.021045e-01 | 0.299 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 5.174965e-01 | 0.286 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 5.197681e-01 | 0.284 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 5.283829e-01 | 0.277 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 5.337342e-01 | 0.273 |
| R-HSA-186712 | Regulation of beta-cell development | 5.337342e-01 | 0.273 |
| R-HSA-983189 | Kinesins | 5.390250e-01 | 0.268 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 5.390250e-01 | 0.268 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 5.442562e-01 | 0.264 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 5.442562e-01 | 0.264 |
| R-HSA-445717 | Aquaporin-mediated transport | 5.442562e-01 | 0.264 |
| R-HSA-72312 | rRNA processing | 5.472121e-01 | 0.262 |
| R-HSA-112315 | Transmission across Chemical Synapses | 5.482838e-01 | 0.261 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 5.494283e-01 | 0.260 |
| R-HSA-186797 | Signaling by PDGF | 5.494283e-01 | 0.260 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 5.545420e-01 | 0.256 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 5.545420e-01 | 0.256 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 5.545420e-01 | 0.256 |
| R-HSA-74751 | Insulin receptor signalling cascade | 5.595980e-01 | 0.252 |
| R-HSA-166520 | Signaling by NTRKs | 5.637105e-01 | 0.249 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 5.695394e-01 | 0.244 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 5.695394e-01 | 0.244 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 5.702115e-01 | 0.244 |
| R-HSA-168249 | Innate Immune System | 5.748416e-01 | 0.240 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 5.766426e-01 | 0.239 |
| R-HSA-5668914 | Diseases of metabolism | 5.780199e-01 | 0.238 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 5.792576e-01 | 0.237 |
| R-HSA-72766 | Translation | 5.819781e-01 | 0.235 |
| R-HSA-204005 | COPII-mediated vesicle transport | 5.887576e-01 | 0.230 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 5.887576e-01 | 0.230 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 5.980442e-01 | 0.223 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 6.026090e-01 | 0.220 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 6.071223e-01 | 0.217 |
| R-HSA-1226099 | Signaling by FGFR in disease | 6.071223e-01 | 0.217 |
| R-HSA-380287 | Centrosome maturation | 6.115845e-01 | 0.214 |
| R-HSA-216083 | Integrin cell surface interactions | 6.246711e-01 | 0.204 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 6.289351e-01 | 0.201 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 6.351005e-01 | 0.197 |
| R-HSA-6798695 | Neutrophil degranulation | 6.352422e-01 | 0.197 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 6.455146e-01 | 0.190 |
| R-HSA-162582 | Signal Transduction | 6.513555e-01 | 0.186 |
| R-HSA-611105 | Respiratory electron transport | 6.566010e-01 | 0.183 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 6.613573e-01 | 0.180 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 6.613573e-01 | 0.180 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 6.613573e-01 | 0.180 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 6.690125e-01 | 0.175 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 6.764956e-01 | 0.170 |
| R-HSA-73884 | Base Excision Repair | 6.764956e-01 | 0.170 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 6.801738e-01 | 0.167 |
| R-HSA-381070 | IRE1alpha activates chaperones | 6.838104e-01 | 0.165 |
| R-HSA-74752 | Signaling by Insulin receptor | 6.874059e-01 | 0.163 |
| R-HSA-5617833 | Cilium Assembly | 6.880915e-01 | 0.162 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 6.944753e-01 | 0.158 |
| R-HSA-428157 | Sphingolipid metabolism | 7.148496e-01 | 0.146 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 7.243705e-01 | 0.140 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 7.306082e-01 | 0.136 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 7.336742e-01 | 0.134 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 7.336742e-01 | 0.134 |
| R-HSA-392499 | Metabolism of proteins | 7.353187e-01 | 0.134 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 7.597523e-01 | 0.119 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 7.678677e-01 | 0.115 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 7.705118e-01 | 0.113 |
| R-HSA-2980736 | Peptide hormone metabolism | 7.757104e-01 | 0.110 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 7.782088e-01 | 0.109 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 7.906139e-01 | 0.102 |
| R-HSA-6809371 | Formation of the cornified envelope | 7.930003e-01 | 0.101 |
| R-HSA-194138 | Signaling by VEGF | 7.976921e-01 | 0.098 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 7.976921e-01 | 0.098 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 7.976921e-01 | 0.098 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 7.976921e-01 | 0.098 |
| R-HSA-114608 | Platelet degranulation | 8.022781e-01 | 0.096 |
| R-HSA-112316 | Neuronal System | 8.090317e-01 | 0.092 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 8.139709e-01 | 0.089 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 8.154250e-01 | 0.089 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 8.175300e-01 | 0.087 |
| R-HSA-163685 | Integration of energy metabolism | 8.257139e-01 | 0.083 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 8.354323e-01 | 0.078 |
| R-HSA-9658195 | Leishmania infection | 8.580270e-01 | 0.066 |
| R-HSA-9824443 | Parasitic Infection Pathways | 8.580270e-01 | 0.066 |
| R-HSA-1989781 | PPARA activates gene expression | 8.614700e-01 | 0.065 |
| R-HSA-1280218 | Adaptive Immune System | 8.618251e-01 | 0.065 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 8.646167e-01 | 0.063 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 8.886488e-01 | 0.051 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 8.886488e-01 | 0.051 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 8.899222e-01 | 0.051 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 8.911811e-01 | 0.050 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 9.003833e-01 | 0.046 |
| R-HSA-8957322 | Metabolism of steroids | 9.039920e-01 | 0.044 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 9.211680e-01 | 0.036 |
| R-HSA-6805567 | Keratinization | 9.247195e-01 | 0.034 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.346985e-01 | 0.029 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 9.422613e-01 | 0.026 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 9.485576e-01 | 0.023 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.522611e-01 | 0.021 |
| R-HSA-418594 | G alpha (i) signalling events | 9.566535e-01 | 0.019 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 9.656788e-01 | 0.015 |
| R-HSA-1483257 | Phospholipid metabolism | 9.730896e-01 | 0.012 |
| R-HSA-1474244 | Extracellular matrix organization | 9.822789e-01 | 0.008 |
| R-HSA-109582 | Hemostasis | 9.829395e-01 | 0.007 |
| R-HSA-211859 | Biological oxidations | 9.981435e-01 | 0.001 |
| R-HSA-388396 | GPCR downstream signalling | 9.990058e-01 | 0.000 |
| R-HSA-372790 | Signaling by GPCR | 9.995957e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.996125e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999864e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.832 | 0.221 | 2 | 0.901 |
BMPR1B |
0.825 | 0.348 | 1 | 0.743 |
MOS |
0.825 | 0.359 | 1 | 0.844 |
CDC7 |
0.823 | 0.166 | 1 | 0.831 |
BMPR1A |
0.821 | 0.372 | 1 | 0.746 |
KIS |
0.820 | 0.130 | 1 | 0.557 |
DSTYK |
0.817 | 0.183 | 2 | 0.885 |
TGFBR1 |
0.816 | 0.322 | -2 | 0.872 |
GRK1 |
0.815 | 0.127 | -2 | 0.737 |
ACVR2B |
0.815 | 0.350 | -2 | 0.874 |
TGFBR2 |
0.813 | 0.207 | -2 | 0.894 |
GCN2 |
0.813 | 0.078 | 2 | 0.820 |
ACVR2A |
0.812 | 0.319 | -2 | 0.878 |
GRK4 |
0.810 | 0.137 | -2 | 0.780 |
ALK2 |
0.810 | 0.331 | -2 | 0.887 |
IKKB |
0.808 | -0.032 | -2 | 0.635 |
IKKA |
0.808 | 0.078 | -2 | 0.632 |
GRK6 |
0.807 | 0.138 | 1 | 0.763 |
GRK7 |
0.807 | 0.195 | 1 | 0.665 |
CK2A2 |
0.806 | 0.314 | 1 | 0.814 |
ALK4 |
0.806 | 0.278 | -2 | 0.878 |
CLK3 |
0.805 | 0.090 | 1 | 0.687 |
PRPK |
0.805 | -0.049 | -1 | 0.813 |
BMPR2 |
0.804 | 0.170 | -2 | 0.806 |
FAM20C |
0.804 | 0.103 | 2 | 0.608 |
TBK1 |
0.804 | -0.021 | 1 | 0.666 |
RAF1 |
0.803 | -0.068 | 1 | 0.759 |
GRK5 |
0.802 | 0.013 | -3 | 0.619 |
IKKE |
0.802 | -0.028 | 1 | 0.670 |
CAMK2G |
0.801 | -0.004 | 2 | 0.796 |
NEK6 |
0.800 | 0.046 | -2 | 0.806 |
PLK1 |
0.799 | 0.145 | -2 | 0.801 |
PDHK4 |
0.798 | -0.179 | 1 | 0.764 |
NEK7 |
0.797 | -0.041 | -3 | 0.532 |
MTOR |
0.796 | -0.123 | 1 | 0.676 |
ULK2 |
0.796 | -0.127 | 2 | 0.831 |
PIM3 |
0.796 | -0.045 | -3 | 0.527 |
ATR |
0.796 | -0.046 | 1 | 0.732 |
ATM |
0.796 | 0.047 | 1 | 0.685 |
PDHK1 |
0.795 | -0.136 | 1 | 0.760 |
TLK2 |
0.794 | 0.183 | 1 | 0.707 |
CAMK1B |
0.794 | -0.093 | -3 | 0.533 |
NDR2 |
0.793 | -0.053 | -3 | 0.525 |
MLK1 |
0.793 | -0.050 | 2 | 0.841 |
CK2A1 |
0.793 | 0.268 | 1 | 0.802 |
ULK1 |
0.792 | -0.108 | -3 | 0.559 |
PLK3 |
0.792 | 0.108 | 2 | 0.786 |
RSK2 |
0.789 | -0.044 | -3 | 0.453 |
LATS1 |
0.789 | 0.093 | -3 | 0.574 |
RIPK3 |
0.789 | -0.130 | 3 | 0.727 |
GRK2 |
0.789 | 0.051 | -2 | 0.671 |
NLK |
0.788 | -0.125 | 1 | 0.697 |
PKN3 |
0.788 | -0.081 | -3 | 0.505 |
ERK5 |
0.788 | -0.088 | 1 | 0.630 |
ANKRD3 |
0.787 | -0.028 | 1 | 0.762 |
BCKDK |
0.787 | -0.135 | -1 | 0.788 |
CDKL1 |
0.787 | -0.092 | -3 | 0.491 |
TLK1 |
0.786 | 0.195 | -2 | 0.826 |
SKMLCK |
0.786 | -0.104 | -2 | 0.683 |
CAMK2B |
0.785 | 0.000 | 2 | 0.763 |
DLK |
0.785 | -0.067 | 1 | 0.751 |
GRK3 |
0.785 | 0.067 | -2 | 0.657 |
HUNK |
0.785 | -0.142 | 2 | 0.840 |
CK1E |
0.784 | -0.007 | -3 | 0.415 |
P90RSK |
0.784 | -0.073 | -3 | 0.466 |
MLK4 |
0.784 | 0.035 | 2 | 0.763 |
PLK2 |
0.784 | 0.133 | -3 | 0.605 |
CAMLCK |
0.784 | -0.104 | -2 | 0.695 |
TTBK2 |
0.783 | -0.074 | 2 | 0.718 |
YSK4 |
0.783 | 0.013 | 1 | 0.699 |
NIK |
0.783 | -0.177 | -3 | 0.554 |
DAPK2 |
0.782 | -0.109 | -3 | 0.534 |
CHAK2 |
0.781 | -0.112 | -1 | 0.773 |
PRKD1 |
0.781 | -0.100 | -3 | 0.461 |
MST4 |
0.781 | -0.108 | 2 | 0.861 |
NDR1 |
0.780 | -0.118 | -3 | 0.508 |
MARK4 |
0.780 | -0.122 | 4 | 0.824 |
CDK8 |
0.780 | -0.051 | 1 | 0.545 |
CK1D |
0.780 | 0.003 | -3 | 0.385 |
RSK3 |
0.780 | -0.086 | -3 | 0.448 |
PIM1 |
0.780 | -0.064 | -3 | 0.467 |
MEK1 |
0.779 | -0.029 | 2 | 0.852 |
MASTL |
0.779 | -0.243 | -2 | 0.678 |
MLK3 |
0.779 | -0.038 | 2 | 0.764 |
CK1G1 |
0.779 | 0.001 | -3 | 0.481 |
NUAK2 |
0.778 | -0.142 | -3 | 0.496 |
PERK |
0.778 | 0.089 | -2 | 0.867 |
LATS2 |
0.778 | -0.089 | -5 | 0.707 |
RSK4 |
0.778 | -0.037 | -3 | 0.442 |
MAPKAPK2 |
0.777 | -0.070 | -3 | 0.410 |
SRPK1 |
0.777 | -0.059 | -3 | 0.450 |
JNK3 |
0.777 | 0.007 | 1 | 0.524 |
PKCD |
0.777 | -0.089 | 2 | 0.818 |
NEK9 |
0.777 | -0.192 | 2 | 0.856 |
MEKK3 |
0.776 | -0.013 | 1 | 0.713 |
HIPK4 |
0.776 | -0.096 | 1 | 0.665 |
P70S6KB |
0.776 | -0.097 | -3 | 0.470 |
SRPK2 |
0.776 | -0.044 | -3 | 0.396 |
SRPK3 |
0.776 | -0.036 | -3 | 0.444 |
CDK1 |
0.776 | -0.001 | 1 | 0.498 |
PKN2 |
0.776 | -0.153 | -3 | 0.488 |
CDKL5 |
0.776 | -0.110 | -3 | 0.475 |
AURA |
0.776 | -0.015 | -2 | 0.502 |
PRKD2 |
0.775 | -0.103 | -3 | 0.416 |
TSSK2 |
0.775 | -0.111 | -5 | 0.802 |
IRE2 |
0.775 | -0.067 | 2 | 0.818 |
PKR |
0.774 | -0.056 | 1 | 0.742 |
WNK3 |
0.774 | -0.290 | 1 | 0.726 |
AMPKA1 |
0.773 | -0.160 | -3 | 0.500 |
PKACG |
0.773 | -0.118 | -2 | 0.576 |
ICK |
0.773 | -0.119 | -3 | 0.512 |
CAMK2D |
0.773 | -0.161 | -3 | 0.481 |
JNK2 |
0.773 | -0.005 | 1 | 0.489 |
MLK2 |
0.773 | -0.176 | 2 | 0.839 |
CK1A2 |
0.773 | -0.020 | -3 | 0.374 |
BRAF |
0.773 | -0.000 | -4 | 0.806 |
PLK4 |
0.772 | -0.050 | 2 | 0.688 |
WNK1 |
0.772 | -0.229 | -2 | 0.680 |
RIPK1 |
0.772 | -0.261 | 1 | 0.718 |
CAMK2A |
0.772 | -0.058 | 2 | 0.764 |
MSK2 |
0.771 | -0.103 | -3 | 0.425 |
TSSK1 |
0.771 | -0.115 | -3 | 0.517 |
CLK2 |
0.771 | 0.011 | -3 | 0.453 |
AURC |
0.770 | -0.058 | -2 | 0.516 |
CAMK4 |
0.770 | -0.175 | -3 | 0.475 |
DNAPK |
0.770 | -0.046 | 1 | 0.625 |
PRP4 |
0.769 | -0.032 | -3 | 0.518 |
CLK4 |
0.769 | -0.056 | -3 | 0.457 |
NIM1 |
0.769 | -0.168 | 3 | 0.737 |
VRK2 |
0.769 | -0.233 | 1 | 0.766 |
MEKK2 |
0.769 | -0.000 | 2 | 0.836 |
CDK19 |
0.769 | -0.070 | 1 | 0.503 |
DYRK2 |
0.769 | -0.074 | 1 | 0.572 |
HRI |
0.768 | -0.022 | -2 | 0.829 |
DRAK1 |
0.768 | -0.072 | 1 | 0.699 |
PAK1 |
0.768 | -0.111 | -2 | 0.599 |
MSK1 |
0.767 | -0.073 | -3 | 0.426 |
SMG1 |
0.767 | -0.093 | 1 | 0.687 |
ZAK |
0.767 | -0.084 | 1 | 0.722 |
PRKX |
0.767 | -0.036 | -3 | 0.374 |
MAPKAPK3 |
0.767 | -0.172 | -3 | 0.423 |
P38D |
0.767 | 0.000 | 1 | 0.442 |
P38G |
0.767 | -0.018 | 1 | 0.417 |
IRE1 |
0.766 | -0.182 | 1 | 0.683 |
MEKK1 |
0.766 | -0.088 | 1 | 0.728 |
PKACB |
0.765 | -0.064 | -2 | 0.517 |
MST2 |
0.765 | 0.069 | 1 | 0.711 |
P38B |
0.765 | -0.036 | 1 | 0.478 |
AURB |
0.764 | -0.069 | -2 | 0.511 |
AMPKA2 |
0.764 | -0.164 | -3 | 0.469 |
CHK1 |
0.764 | -0.102 | -3 | 0.489 |
MYLK4 |
0.763 | -0.112 | -2 | 0.606 |
PASK |
0.763 | -0.014 | -3 | 0.527 |
NUAK1 |
0.763 | -0.150 | -3 | 0.461 |
SIK |
0.763 | -0.133 | -3 | 0.436 |
GSK3A |
0.762 | 0.036 | 4 | 0.431 |
MARK2 |
0.762 | -0.108 | 4 | 0.727 |
QSK |
0.762 | -0.136 | 4 | 0.793 |
P38A |
0.762 | -0.069 | 1 | 0.543 |
BRSK1 |
0.762 | -0.127 | -3 | 0.451 |
CDK2 |
0.762 | -0.070 | 1 | 0.576 |
PAK2 |
0.761 | -0.141 | -2 | 0.596 |
CDK5 |
0.761 | -0.055 | 1 | 0.550 |
CLK1 |
0.761 | -0.077 | -3 | 0.417 |
PRKD3 |
0.760 | -0.132 | -3 | 0.399 |
MEK5 |
0.760 | -0.210 | 2 | 0.854 |
JNK1 |
0.760 | 0.004 | 1 | 0.484 |
PAK3 |
0.759 | -0.177 | -2 | 0.593 |
ERK1 |
0.759 | -0.060 | 1 | 0.471 |
PINK1 |
0.759 | -0.138 | 1 | 0.693 |
QIK |
0.759 | -0.229 | -3 | 0.476 |
CDK13 |
0.758 | -0.091 | 1 | 0.514 |
MARK3 |
0.758 | -0.119 | 4 | 0.754 |
ERK2 |
0.758 | -0.074 | 1 | 0.515 |
CDK7 |
0.758 | -0.108 | 1 | 0.545 |
TTK |
0.758 | 0.227 | -2 | 0.843 |
PKCG |
0.758 | -0.156 | 2 | 0.763 |
TAO3 |
0.758 | -0.085 | 1 | 0.705 |
CDK17 |
0.758 | -0.057 | 1 | 0.420 |
PKCA |
0.758 | -0.136 | 2 | 0.760 |
CDK18 |
0.757 | -0.068 | 1 | 0.466 |
TTBK1 |
0.757 | -0.112 | 2 | 0.643 |
PKCB |
0.757 | -0.145 | 2 | 0.761 |
AKT2 |
0.756 | -0.096 | -3 | 0.378 |
CHAK1 |
0.756 | -0.226 | 2 | 0.783 |
SGK3 |
0.756 | -0.120 | -3 | 0.417 |
GSK3B |
0.756 | -0.013 | 4 | 0.420 |
GAK |
0.756 | -0.034 | 1 | 0.712 |
NEK8 |
0.756 | -0.103 | 2 | 0.849 |
CAMK1G |
0.756 | -0.134 | -3 | 0.434 |
DCAMKL1 |
0.755 | -0.122 | -3 | 0.444 |
NEK5 |
0.755 | -0.175 | 1 | 0.714 |
PHKG1 |
0.755 | -0.178 | -3 | 0.480 |
BRSK2 |
0.755 | -0.179 | -3 | 0.459 |
NEK2 |
0.755 | -0.251 | 2 | 0.822 |
CDK3 |
0.755 | -0.025 | 1 | 0.438 |
MELK |
0.755 | -0.204 | -3 | 0.448 |
MARK1 |
0.755 | -0.141 | 4 | 0.780 |
HIPK2 |
0.755 | -0.063 | 1 | 0.490 |
PKCH |
0.754 | -0.166 | 2 | 0.761 |
CAMKK1 |
0.753 | -0.171 | -2 | 0.648 |
PKG2 |
0.752 | -0.127 | -2 | 0.516 |
MNK1 |
0.752 | -0.158 | -2 | 0.614 |
DYRK1A |
0.752 | -0.099 | 1 | 0.605 |
HIPK1 |
0.752 | -0.092 | 1 | 0.585 |
PIM2 |
0.752 | -0.110 | -3 | 0.423 |
EEF2K |
0.752 | -0.016 | 3 | 0.750 |
DYRK4 |
0.752 | -0.059 | 1 | 0.503 |
MNK2 |
0.752 | -0.180 | -2 | 0.599 |
PKACA |
0.751 | -0.077 | -2 | 0.473 |
SMMLCK |
0.751 | -0.134 | -3 | 0.479 |
ALPHAK3 |
0.751 | 0.141 | -1 | 0.764 |
PKCZ |
0.751 | -0.197 | 2 | 0.807 |
DAPK3 |
0.750 | -0.060 | -3 | 0.472 |
MST3 |
0.750 | -0.153 | 2 | 0.847 |
TAK1 |
0.750 | -0.077 | 1 | 0.737 |
SNRK |
0.750 | -0.260 | 2 | 0.743 |
MST1 |
0.749 | -0.017 | 1 | 0.698 |
CDK12 |
0.749 | -0.098 | 1 | 0.489 |
CK1A |
0.749 | -0.014 | -3 | 0.343 |
DCAMKL2 |
0.748 | -0.126 | -3 | 0.461 |
PAK6 |
0.748 | -0.141 | -2 | 0.547 |
CAMK1D |
0.747 | -0.108 | -3 | 0.356 |
DAPK1 |
0.747 | -0.063 | -3 | 0.452 |
MAPKAPK5 |
0.747 | -0.214 | -3 | 0.388 |
P70S6K |
0.746 | -0.128 | -3 | 0.386 |
GCK |
0.746 | -0.095 | 1 | 0.698 |
AKT1 |
0.746 | -0.102 | -3 | 0.378 |
DYRK1B |
0.746 | -0.088 | 1 | 0.515 |
NEK11 |
0.746 | -0.228 | 1 | 0.703 |
WNK4 |
0.746 | -0.253 | -2 | 0.686 |
CAMKK2 |
0.746 | -0.193 | -2 | 0.635 |
MPSK1 |
0.746 | -0.139 | 1 | 0.654 |
SSTK |
0.744 | -0.151 | 4 | 0.794 |
TAO2 |
0.744 | -0.169 | 2 | 0.860 |
DYRK3 |
0.743 | -0.102 | 1 | 0.598 |
CDK16 |
0.743 | -0.061 | 1 | 0.434 |
IRAK4 |
0.742 | -0.255 | 1 | 0.695 |
MINK |
0.741 | -0.135 | 1 | 0.698 |
CDK14 |
0.741 | -0.107 | 1 | 0.505 |
OSR1 |
0.741 | 0.009 | 2 | 0.830 |
PDHK3_TYR |
0.741 | 0.191 | 4 | 0.886 |
PDK1 |
0.740 | -0.181 | 1 | 0.712 |
IRAK1 |
0.740 | -0.286 | -1 | 0.676 |
CDK9 |
0.740 | -0.144 | 1 | 0.518 |
SGK1 |
0.739 | -0.078 | -3 | 0.322 |
LKB1 |
0.739 | -0.228 | -3 | 0.498 |
HIPK3 |
0.739 | -0.146 | 1 | 0.577 |
PKCT |
0.739 | -0.185 | 2 | 0.771 |
PDHK4_TYR |
0.738 | 0.163 | 2 | 0.899 |
MAP3K15 |
0.738 | -0.180 | 1 | 0.695 |
PDHK1_TYR |
0.737 | 0.168 | -1 | 0.881 |
VRK1 |
0.737 | -0.181 | 2 | 0.884 |
MAP2K6_TYR |
0.736 | 0.151 | -1 | 0.868 |
HGK |
0.736 | -0.151 | 3 | 0.771 |
MEK2 |
0.736 | -0.163 | 2 | 0.830 |
RIPK2 |
0.736 | -0.231 | 1 | 0.684 |
BMPR2_TYR |
0.735 | 0.107 | -1 | 0.851 |
ERK7 |
0.735 | -0.056 | 2 | 0.552 |
PHKG2 |
0.735 | -0.213 | -3 | 0.448 |
TNIK |
0.735 | -0.134 | 3 | 0.762 |
CHK2 |
0.735 | -0.126 | -3 | 0.322 |
PAK5 |
0.734 | -0.148 | -2 | 0.485 |
CDK10 |
0.733 | -0.100 | 1 | 0.491 |
AKT3 |
0.733 | -0.094 | -3 | 0.326 |
NEK4 |
0.733 | -0.273 | 1 | 0.690 |
MRCKA |
0.733 | -0.103 | -3 | 0.431 |
CK1G3 |
0.732 | -0.010 | -3 | 0.315 |
HPK1 |
0.732 | -0.174 | 1 | 0.684 |
CAMK1A |
0.732 | -0.114 | -3 | 0.340 |
PKCI |
0.732 | -0.194 | 2 | 0.778 |
MAP2K4_TYR |
0.732 | 0.062 | -1 | 0.853 |
SLK |
0.732 | -0.140 | -2 | 0.580 |
PAK4 |
0.731 | -0.131 | -2 | 0.492 |
TXK |
0.731 | 0.221 | 1 | 0.796 |
SBK |
0.731 | -0.088 | -3 | 0.284 |
LRRK2 |
0.731 | -0.263 | 2 | 0.862 |
ROCK2 |
0.730 | -0.111 | -3 | 0.449 |
MEKK6 |
0.730 | -0.278 | 1 | 0.691 |
MRCKB |
0.729 | -0.118 | -3 | 0.406 |
PKCE |
0.729 | -0.149 | 2 | 0.750 |
NEK1 |
0.729 | -0.270 | 1 | 0.698 |
YANK3 |
0.728 | -0.058 | 2 | 0.430 |
CK1G2 |
0.727 | 0.025 | -3 | 0.396 |
PKN1 |
0.727 | -0.160 | -3 | 0.381 |
YSK1 |
0.726 | -0.183 | 2 | 0.826 |
KHS1 |
0.726 | -0.159 | 1 | 0.683 |
KHS2 |
0.726 | -0.129 | 1 | 0.691 |
LOK |
0.726 | -0.204 | -2 | 0.609 |
STK33 |
0.725 | -0.208 | 2 | 0.654 |
MAK |
0.725 | -0.090 | -2 | 0.574 |
TESK1_TYR |
0.725 | -0.113 | 3 | 0.822 |
CDK6 |
0.724 | -0.107 | 1 | 0.488 |
DMPK1 |
0.724 | -0.086 | -3 | 0.431 |
EPHA6 |
0.724 | 0.051 | -1 | 0.844 |
INSRR |
0.724 | 0.082 | 3 | 0.704 |
MAP2K7_TYR |
0.723 | -0.193 | 2 | 0.874 |
FGR |
0.723 | 0.062 | 1 | 0.720 |
EPHB4 |
0.722 | 0.052 | -1 | 0.821 |
EPHA4 |
0.721 | 0.066 | 2 | 0.786 |
FYN |
0.721 | 0.159 | -1 | 0.748 |
PKMYT1_TYR |
0.721 | -0.164 | 3 | 0.817 |
FER |
0.721 | 0.040 | 1 | 0.772 |
YES1 |
0.720 | 0.064 | -1 | 0.784 |
SYK |
0.720 | 0.158 | -1 | 0.794 |
CDK4 |
0.720 | -0.117 | 1 | 0.479 |
BLK |
0.720 | 0.133 | -1 | 0.791 |
EPHB2 |
0.719 | 0.104 | -1 | 0.805 |
PINK1_TYR |
0.719 | -0.164 | 1 | 0.743 |
CSF1R |
0.719 | -0.006 | 3 | 0.743 |
PBK |
0.719 | -0.157 | 1 | 0.635 |
BUB1 |
0.718 | -0.120 | -5 | 0.757 |
SRMS |
0.718 | 0.056 | 1 | 0.765 |
JAK3 |
0.717 | 0.004 | 1 | 0.710 |
STLK3 |
0.717 | -0.104 | 1 | 0.684 |
CRIK |
0.717 | -0.095 | -3 | 0.384 |
KIT |
0.717 | 0.017 | 3 | 0.756 |
FLT1 |
0.717 | 0.080 | -1 | 0.856 |
NEK3 |
0.716 | -0.257 | 1 | 0.676 |
LCK |
0.716 | 0.087 | -1 | 0.774 |
EPHB1 |
0.716 | 0.038 | 1 | 0.755 |
RET |
0.716 | -0.120 | 1 | 0.710 |
MOK |
0.716 | -0.128 | 1 | 0.577 |
ASK1 |
0.715 | -0.208 | 1 | 0.691 |
ROCK1 |
0.715 | -0.125 | -3 | 0.419 |
PKG1 |
0.715 | -0.142 | -2 | 0.445 |
ABL2 |
0.715 | -0.008 | -1 | 0.776 |
MYO3A |
0.714 | -0.149 | 1 | 0.687 |
HCK |
0.714 | 0.019 | -1 | 0.770 |
JAK2 |
0.713 | -0.110 | 1 | 0.709 |
EGFR |
0.713 | 0.077 | 1 | 0.609 |
FGFR2 |
0.713 | -0.019 | 3 | 0.768 |
MST1R |
0.713 | -0.106 | 3 | 0.758 |
PTK2 |
0.713 | 0.114 | -1 | 0.786 |
TYK2 |
0.713 | -0.158 | 1 | 0.707 |
ROS1 |
0.712 | -0.103 | 3 | 0.708 |
EPHB3 |
0.712 | 0.010 | -1 | 0.802 |
ITK |
0.712 | 0.018 | -1 | 0.737 |
FLT3 |
0.712 | -0.025 | 3 | 0.736 |
MET |
0.711 | 0.020 | 3 | 0.736 |
TYRO3 |
0.711 | -0.118 | 3 | 0.737 |
ABL1 |
0.710 | -0.046 | -1 | 0.761 |
BIKE |
0.709 | -0.099 | 1 | 0.584 |
FGFR3 |
0.709 | 0.017 | 3 | 0.739 |
KDR |
0.709 | -0.048 | 3 | 0.715 |
LYN |
0.708 | 0.058 | 3 | 0.708 |
MYO3B |
0.708 | -0.193 | 2 | 0.832 |
PDGFRB |
0.708 | -0.064 | 3 | 0.749 |
NTRK1 |
0.708 | -0.027 | -1 | 0.805 |
ERBB2 |
0.708 | -0.016 | 1 | 0.685 |
FGFR1 |
0.707 | -0.051 | 3 | 0.731 |
DDR1 |
0.707 | -0.173 | 4 | 0.813 |
EPHA5 |
0.707 | 0.070 | 2 | 0.782 |
HASPIN |
0.707 | -0.135 | -1 | 0.596 |
FRK |
0.707 | 0.052 | -1 | 0.797 |
TEC |
0.706 | 0.009 | -1 | 0.657 |
BMX |
0.706 | 0.007 | -1 | 0.657 |
FGFR4 |
0.705 | 0.041 | -1 | 0.770 |
SRC |
0.705 | 0.053 | -1 | 0.749 |
FLT4 |
0.705 | -0.019 | 3 | 0.729 |
TAO1 |
0.705 | -0.216 | 1 | 0.651 |
EPHA7 |
0.705 | -0.005 | 2 | 0.796 |
LIMK1_TYR |
0.704 | -0.281 | 2 | 0.869 |
LIMK2_TYR |
0.704 | -0.265 | -3 | 0.550 |
TEK |
0.704 | -0.095 | 3 | 0.695 |
EPHA8 |
0.704 | 0.043 | -1 | 0.795 |
MERTK |
0.703 | -0.047 | 3 | 0.730 |
EPHA3 |
0.703 | -0.032 | 2 | 0.769 |
ERBB4 |
0.700 | 0.048 | 1 | 0.621 |
INSR |
0.700 | -0.047 | 3 | 0.681 |
TNK2 |
0.700 | -0.116 | 3 | 0.726 |
NTRK2 |
0.700 | -0.066 | 3 | 0.718 |
NTRK3 |
0.700 | -0.041 | -1 | 0.765 |
BTK |
0.700 | -0.104 | -1 | 0.687 |
JAK1 |
0.699 | -0.109 | 1 | 0.670 |
YANK2 |
0.699 | -0.066 | 2 | 0.445 |
ALK |
0.698 | -0.096 | 3 | 0.693 |
PTK2B |
0.698 | -0.001 | -1 | 0.694 |
EPHA2 |
0.698 | 0.050 | -1 | 0.775 |
AXL |
0.696 | -0.142 | 3 | 0.730 |
PTK6 |
0.696 | -0.123 | -1 | 0.667 |
LTK |
0.696 | -0.102 | 3 | 0.724 |
IGF1R |
0.695 | 0.001 | 3 | 0.642 |
PDGFRA |
0.695 | -0.180 | 3 | 0.748 |
TNNI3K_TYR |
0.694 | -0.124 | 1 | 0.725 |
NEK10_TYR |
0.694 | -0.170 | 1 | 0.610 |
MATK |
0.694 | -0.069 | -1 | 0.721 |
DDR2 |
0.692 | -0.085 | 3 | 0.719 |
CSK |
0.690 | -0.079 | 2 | 0.796 |
AAK1 |
0.688 | -0.076 | 1 | 0.475 |
WEE1_TYR |
0.688 | -0.160 | -1 | 0.678 |
EPHA1 |
0.688 | -0.128 | 3 | 0.707 |
ZAP70 |
0.686 | 0.021 | -1 | 0.695 |
TNK1 |
0.685 | -0.249 | 3 | 0.726 |
MUSK |
0.678 | -0.107 | 1 | 0.575 |
FES |
0.674 | -0.069 | -1 | 0.633 |