Motif 839 (n=124)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| E9PAV3 | NACA | S2054 | ochoa | Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC) | Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250|UniProtKB:P70670}. |
| O00203 | AP3B1 | S26 | ochoa | AP-3 complex subunit beta-1 (Adaptor protein complex AP-3 subunit beta-1) (Adaptor-related protein complex 3 subunit beta-1) (Beta-3A-adaptin) (Clathrin assembly protein complex 3 beta-1 large chain) | Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. {ECO:0000305|PubMed:9151686}. |
| O14874 | BCKDK | S339 | ochoa | Branched-chain alpha-ketoacid dehydrogenase kinase (BCKDH kinase) (BCKDHKIN) (BDK) (EC 2.7.11.1) ([3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial) (EC 2.7.11.4) | Serine/threonine-protein kinase component of macronutrients metabolism. Forms a functional kinase and phosphatase pair with PPM1K, serving as a metabolic regulatory node that coordinates branched-chain amino acids (BCAAs) with glucose and lipid metabolism via two distinct phosphoprotein targets: mitochondrial BCKDHA subunit of the branched-chain alpha-ketoacid dehydrogenase (BCKDH) complex and cytosolic ACLY, a lipogenic enzyme of Krebs cycle (PubMed:24449431, PubMed:29779826, PubMed:37558654). Phosphorylates and inactivates mitochondrial BCKDH complex a multisubunit complex consisting of three multimeric components each involved in different steps of BCAA catabolism: E1 composed of BCKDHA and BCKDHB, E2 core composed of DBT monomers, and E3 composed of DLD monomers. Associates with the E2 component of BCKDH complex and phosphorylates BCKDHA on Ser-337, leading to conformational changes that interrupt substrate channeling between E1 and E2 and inactivates the BCKDH complex (PubMed:29779826, PubMed:37558654). Phosphorylates ACLY on Ser-455 in response to changes in cellular carbohydrate abundance such as occurs during fasting to feeding metabolic transition. Refeeding stimulates MLXIPL/ChREBP transcription factor, leading to increased BCKDK to PPM1K expression ratio, phosphorylation and activation of ACLY that ultimately results in the generation of malonyl-CoA and oxaloacetate immediate substrates of de novo lipogenesis and glucogenesis, respectively (PubMed:29779826). Recognizes phosphosites having SxxE/D canonical motif (PubMed:29779826). {ECO:0000269|PubMed:24449431, ECO:0000269|PubMed:29779826, ECO:0000269|PubMed:37558654}. |
| O14896 | IRF6 | S413 | ochoa|psp | Interferon regulatory factor 6 (IRF-6) | Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development (By similarity). Plays a role in regulating mammary epithelial cell proliferation (By similarity). May regulate WDR65 transcription (By similarity). {ECO:0000250}. |
| O14917 | PCDH17 | S1108 | ochoa | Protocadherin-17 (Protocadherin-68) | Potential calcium-dependent cell-adhesion protein. |
| O15379 | HDAC3 | S374 | psp | Histone deacetylase 3 (HD3) (EC 3.5.1.98) (Protein deacetylase HDAC3) (EC 3.5.1.-) (Protein deacylase HDAC3) (EC 3.5.1.-) (RPD3-2) (SMAP45) | Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates (PubMed:21030595, PubMed:21444723, PubMed:23911289, PubMed:25301942, PubMed:28167758, PubMed:28497810, PubMed:32404892, PubMed:22230954). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (PubMed:23911289). Histone deacetylases act via the formation of large multiprotein complexes, such as N-Cor repressor complex, which activate the histone deacetylase activity (PubMed:23911289, PubMed:22230954). Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression (PubMed:23911289). Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation (By similarity). Contributes, together with XBP1 isoform 1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress (PubMed:25190803). Regulates both the transcriptional activation and repression phases of the circadian clock in a deacetylase activity-independent manner (By similarity). During the activation phase, promotes the accumulation of ubiquitinated BMAL1 at the E-boxes and during the repression phase, blocks FBXL3-mediated CRY1/2 ubiquitination and promotes the interaction of CRY1 and BMAL1 (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). Also functions as a deacetylase for non-histone targets, such as KAT5, MEF2D, MAPK14, RARA and STAT3 (PubMed:15653507, PubMed:21030595, PubMed:21444723, PubMed:25301942, PubMed:28167758). Serves as a corepressor of RARA, mediating its deacetylation and repression, leading to inhibition of RARE DNA element binding (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758). In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by recognizing other acyl groups: catalyzes removal of (2E)-butenoyl (crotonyl), lactoyl (lactyl) and 2-hydroxyisobutanoyl (2-hydroxyisobutyryl) acyl groups from lysine residues, leading to protein decrotonylation, delactylation and de-2-hydroxyisobutyrylation, respectively (PubMed:28497810, PubMed:29192674, PubMed:34608293, PubMed:35044827). Catalyzes decrotonylation of MAPRE1/EB1 (PubMed:34608293). Mediates delactylation NBN/NBS1, thereby inhibiting DNA double-strand breaks (DSBs) via homologous recombination (HR) (PubMed:38961290). {ECO:0000250|UniProtKB:O88895, ECO:0000269|PubMed:15653507, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:21444723, ECO:0000269|PubMed:22230954, ECO:0000269|PubMed:23911289, ECO:0000269|PubMed:25190803, ECO:0000269|PubMed:25301942, ECO:0000269|PubMed:28167758, ECO:0000269|PubMed:28497810, ECO:0000269|PubMed:29192674, ECO:0000269|PubMed:32404892, ECO:0000269|PubMed:34608293, ECO:0000269|PubMed:35044827, ECO:0000269|PubMed:38961290}. |
| O75569 | PRKRA | S246 | psp | Interferon-inducible double-stranded RNA-dependent protein kinase activator A (PKR-associated protein X) (PKR-associating protein X) (Protein activator of the interferon-induced protein kinase) (Protein kinase, interferon-inducible double-stranded RNA-dependent activator) | Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity). {ECO:0000250, ECO:0000269|PubMed:10336432, ECO:0000269|PubMed:11238927, ECO:0000269|PubMed:16424907, ECO:0000269|PubMed:16982605, ECO:0000269|PubMed:17452327, ECO:0000269|PubMed:9687506}. |
| O75940 | SMNDC1 | S63 | ochoa | Survival of motor neuron-related-splicing factor 30 (30 kDa splicing factor SMNrp) (SMN-related protein) (Survival motor neuron domain-containing protein 1) | Involved in spliceosome assembly. {ECO:0000269|PubMed:11331295, ECO:0000269|PubMed:11331595, ECO:0000269|PubMed:9817934}. |
| O95466 | FMNL1 | S685 | ochoa | Formin-like protein 1 (CLL-associated antigen KW-13) (Leukocyte formin) | May play a role in the control of cell motility and survival of macrophages (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. {ECO:0000250, ECO:0000269|PubMed:21834987}. |
| O95777 | LSM8 | S49 | ochoa | U6 snRNA-associated Sm-like protein LSm8 | Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320). {ECO:0000269|PubMed:10523320, ECO:0000269|PubMed:28781166}. |
| O95831 | AIFM1 | S249 | ochoa | Apoptosis-inducing factor 1, mitochondrial (EC 1.6.99.-) (Programmed cell death protein 8) | Functions both as NADH oxidoreductase and as regulator of apoptosis (PubMed:17094969, PubMed:20362274, PubMed:23217327, PubMed:33168626). In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway (PubMed:20362274). Release into the cytoplasm is mediated upon binding to poly-ADP-ribose chains (By similarity). The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA (PubMed:20362274). Binds to DNA in a sequence-independent manner (PubMed:27178839). Interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates caspase-7 to amplify apoptosis (PubMed:17094969). Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells (PubMed:19418225). In contrast, participates in normal mitochondrial metabolism. Plays an important role in the regulation of respiratory chain biogenesis by interacting with CHCHD4 and controlling CHCHD4 mitochondrial import (PubMed:26004228). {ECO:0000250|UniProtKB:Q9Z0X1, ECO:0000269|PubMed:17094969, ECO:0000269|PubMed:19418225, ECO:0000269|PubMed:20362274, ECO:0000269|PubMed:23217327, ECO:0000269|PubMed:26004228, ECO:0000269|PubMed:27178839, ECO:0000269|PubMed:33168626}.; FUNCTION: [Isoform 4]: Has NADH oxidoreductase activity. Does not induce nuclear apoptosis. {ECO:0000269|PubMed:16644725}.; FUNCTION: [Isoform 5]: Pro-apoptotic isoform. {ECO:0000269|PubMed:16365034}. |
| O95831 | AIFM1 | S371 | ochoa | Apoptosis-inducing factor 1, mitochondrial (EC 1.6.99.-) (Programmed cell death protein 8) | Functions both as NADH oxidoreductase and as regulator of apoptosis (PubMed:17094969, PubMed:20362274, PubMed:23217327, PubMed:33168626). In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway (PubMed:20362274). Release into the cytoplasm is mediated upon binding to poly-ADP-ribose chains (By similarity). The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA (PubMed:20362274). Binds to DNA in a sequence-independent manner (PubMed:27178839). Interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates caspase-7 to amplify apoptosis (PubMed:17094969). Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells (PubMed:19418225). In contrast, participates in normal mitochondrial metabolism. Plays an important role in the regulation of respiratory chain biogenesis by interacting with CHCHD4 and controlling CHCHD4 mitochondrial import (PubMed:26004228). {ECO:0000250|UniProtKB:Q9Z0X1, ECO:0000269|PubMed:17094969, ECO:0000269|PubMed:19418225, ECO:0000269|PubMed:20362274, ECO:0000269|PubMed:23217327, ECO:0000269|PubMed:26004228, ECO:0000269|PubMed:27178839, ECO:0000269|PubMed:33168626}.; FUNCTION: [Isoform 4]: Has NADH oxidoreductase activity. Does not induce nuclear apoptosis. {ECO:0000269|PubMed:16644725}.; FUNCTION: [Isoform 5]: Pro-apoptotic isoform. {ECO:0000269|PubMed:16365034}. |
| O95980 | RECK | S621 | ochoa | Reversion-inducing cysteine-rich protein with Kazal motifs (hRECK) (Suppressor of tumorigenicity 15 protein) | Functions together with ADGRA2 to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:28289266, PubMed:30026314). Plays a key role in Wnt7-specific responses: required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling by decoding Wnt ligands: acts by interacting specifically with the disordered linker region of Wnt7, thereby conferring ligand selectivity for Wnt7 (PubMed:30026314). ADGRA2 is then required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (PubMed:30026314). Also acts as a serine protease inhibitor: negatively regulates matrix metalloproteinase-9 (MMP9) by suppressing MMP9 secretion and by direct inhibition of its enzymatic activity (PubMed:18194466, PubMed:9789069). Also inhibits metalloproteinase activity of MMP2 and MMP14 (MT1-MMP) (PubMed:9789069). {ECO:0000250|UniProtKB:Q9Z0J1, ECO:0000269|PubMed:18194466, ECO:0000269|PubMed:28289266, ECO:0000269|PubMed:30026314, ECO:0000269|PubMed:9789069}. |
| P02775 | PPBP | S70 | ochoa | Platelet basic protein (PBP) (C-X-C motif chemokine 7) (Leukocyte-derived growth factor) (LDGF) (Macrophage-derived growth factor) (MDGF) (Small-inducible cytokine B7) [Cleaved into: Connective tissue-activating peptide III (CTAP-III) (LA-PF4) (Low-affinity platelet factor IV); TC-2; Connective tissue-activating peptide III(1-81) (CTAP-III(1-81)); Beta-thromboglobulin (Beta-TG); Neutrophil-activating peptide 2(74) (NAP-2(74)); Neutrophil-activating peptide 2(73) (NAP-2(73)); Neutrophil-activating peptide 2 (NAP-2); TC-1; Neutrophil-activating peptide 2(1-66) (NAP-2(1-66)); Neutrophil-activating peptide 2(1-63) (NAP-2(1-63))] | LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III(1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation. {ECO:0000269|PubMed:10877842, ECO:0000269|PubMed:7890771, ECO:0000269|PubMed:8950790, ECO:0000269|PubMed:9794434}. |
| P04083 | ANXA1 | S173 | ochoa | Annexin A1 (Annexin I) (Annexin-1) (Calpactin II) (Calpactin-2) (Chromobindin-9) (Lipocortin I) (Phospholipase A2 inhibitory protein) (p35) [Cleaved into: Annexin Ac2-26] | Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity). {ECO:0000250|UniProtKB:P10107, ECO:0000250|UniProtKB:P19619, ECO:0000269|PubMed:17008549, ECO:0000269|PubMed:19625660, ECO:0000269|PubMed:2532504, ECO:0000269|PubMed:2936963, ECO:0000269|PubMed:8425544, ECO:0000269|PubMed:8557678}.; FUNCTION: [Annexin Ac2-26]: Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:15187149, PubMed:22879591, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Promotes resolution of inflammation and wound healing (PubMed:25664854). Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2 (PubMed:22879591). {ECO:0000269|PubMed:15187149, ECO:0000269|PubMed:22879591, ECO:0000269|PubMed:25664854}. |
| P06733 | ENO1 | S37 | ochoa | Alpha-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (C-myc promoter-binding protein) (Enolase 1) (MBP-1) (MPB-1) (Non-neural enolase) (NNE) (Phosphopyruvate hydratase) (Plasminogen-binding protein) | Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (PubMed:1369209, PubMed:29775581). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses (PubMed:10802057, PubMed:12666133, PubMed:2005901, PubMed:29775581). May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (PubMed:12666133). Stimulates immunoglobulin production (PubMed:1369209). {ECO:0000269|PubMed:10802057, ECO:0000269|PubMed:12666133, ECO:0000269|PubMed:1369209, ECO:0000269|PubMed:2005901, ECO:0000269|PubMed:29775581}.; FUNCTION: [Isoform MBP-1]: Binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor. {ECO:0000269|PubMed:10082554}. |
| P07900 | HSP90AA1 | S709 | ochoa | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}. |
| P09104 | ENO2 | S37 | ochoa | Gamma-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 2) (Neural enolase) (Neuron-specific enolase) (NSE) | Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity). {ECO:0000250}. |
| P09936 | UCHL1 | S119 | psp | Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1) (EC 3.4.19.12) (Neuron cytoplasmic protein 9.5) (PGP 9.5) (PGP9.5) (Ubiquitin thioesterase L1) | Deubiquitinase that plays a role in the regulation of several processes such as maintenance of synaptic function, cardiac function, inflammatory response or osteoclastogenesis (PubMed:22212137, PubMed:23359680). Abrogates the ubiquitination of multiple proteins including WWTR1/TAZ, EGFR, HIF1A and beta-site amyloid precursor protein cleaving enzyme 1/BACE1 (PubMed:22212137, PubMed:25615526). In addition, recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin to maintain a stable pool of monoubiquitin that is a key requirement for the ubiquitin-proteasome and the autophagy-lysosome pathways (PubMed:12408865, PubMed:8639624, PubMed:9774100). Regulates amyloid precursor protein/APP processing by promoting BACE1 degradation resulting in decreased amyloid beta production (PubMed:22212137). Plays a role in the immune response by regulating the ability of MHC I molecules to reach cross-presentation compartments competent for generating Ag-MHC I complexes (By similarity). Mediates the 'Lys-48'-linked deubiquitination of the transcriptional coactivator WWTR1/TAZ leading to its stabilization and inhibition of osteoclastogenesis (By similarity). Deubiquitinates and stabilizes epidermal growth factor receptor EGFR to prevent its degradation and to activate its downstream mediators (By similarity). Modulates oxidative activity in skeletal muscle by regulating key mitochondrial oxidative proteins (By similarity). Enhances the activity of hypoxia-inducible factor 1-alpha/HIF1A by abrogateing its VHL E3 ligase-mediated ubiquitination and consequently inhibiting its degradation (PubMed:25615526). {ECO:0000250|UniProtKB:Q9R0P9, ECO:0000269|PubMed:12408865, ECO:0000269|PubMed:22212137, ECO:0000269|PubMed:23359680, ECO:0000269|PubMed:25615526, ECO:0000269|PubMed:8639624, ECO:0000269|PubMed:9774100}. |
| P13639 | EEF2 | S48 | ochoa | Elongation factor 2 (EF-2) (EC 3.6.5.-) | Catalyzes the GTP-dependent ribosomal translocation step during translation elongation (PubMed:26593721). During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively (PubMed:26593721). Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (PubMed:26593721). {ECO:0000269|PubMed:26593721}. |
| P13929 | ENO3 | S37 | ochoa | Beta-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 3) (Muscle-specific enolase) (MSE) (Skeletal muscle enolase) | Glycolytic enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate. Appears to have a function in striated muscle development and regeneration. {ECO:0000250|UniProtKB:P15429}. |
| P15924 | DSP | S2526 | ochoa | Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) | Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). {ECO:0000250|UniProtKB:F1LMV6}. |
| P16615 | ATP2A2 | S553 | ochoa | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) (SR Ca(2+)-ATPase 2) (EC 7.2.2.10) (Calcium pump 2) (Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase) | This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (PubMed:12542527, PubMed:16402920). Involved in autophagy in response to starvation. Upon interaction with VMP1 and activation, controls ER-isolation membrane contacts for autophagosome formation (PubMed:28890335). Also modulates ER contacts with lipid droplets, mitochondria and endosomes (PubMed:28890335). In coordination with FLVCR2 mediates heme-stimulated switching from mitochondrial ATP synthesis to thermogenesis (By similarity). {ECO:0000250|UniProtKB:O55143, ECO:0000269|PubMed:12542527, ECO:0000269|PubMed:16402920, ECO:0000269|PubMed:28890335}.; FUNCTION: [Isoform 2]: Involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca(2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca(2+) signaling cascades that promote osteoclast differentiation and activation. {ECO:0000250|UniProtKB:O55143}. |
| P18206 | VCL | S721 | ochoa | Vinculin (Metavinculin) (MV) | Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. {ECO:0000269|PubMed:20484056}. |
| P21333 | FLNA | S2370 | ochoa|psp | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P23634 | ATP2B4 | S237 | ochoa | Plasma membrane calcium-transporting ATPase 4 (PMCA4) (EC 7.2.2.10) (Matrix-remodeling-associated protein 1) (Plasma membrane calcium ATPase isoform 4) (Plasma membrane calcium pump isoform 4) | Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell (PubMed:8530416). By regulating sperm cell calcium homeostasis, may play a role in sperm motility (By similarity). {ECO:0000250|UniProtKB:Q6Q477, ECO:0000269|PubMed:8530416}. |
| P29401 | TKT | S105 | ochoa | Transketolase (TK) (EC 2.2.1.1) | Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. {ECO:0000269|PubMed:27259054}. |
| P30305 | CDC25B | S397 | psp | M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B) | Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression (PubMed:1836978, PubMed:20360007). Directly dephosphorylates CDK1 and stimulates its kinase activity (PubMed:20360007). Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner (PubMed:17332740). The three isoforms seem to have a different level of activity (PubMed:1836978). {ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:1836978, ECO:0000269|PubMed:20360007}. |
| P33991 | MCM4 | S142 | ochoa | DNA replication licensing factor MCM4 (EC 3.6.4.12) (CDC21 homolog) (P1-CDC21) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:25661590, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:16899510, PubMed:25661590, PubMed:32453425, PubMed:9305914). {ECO:0000269|PubMed:16899510, ECO:0000269|PubMed:25661590, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9305914}. |
| P35251 | RFC1 | S1104 | ochoa | Replication factor C subunit 1 (Activator 1 140 kDa subunit) (A1 140 kDa subunit) (Activator 1 large subunit) (Activator 1 subunit 1) (DNA-binding protein PO-GA) (Replication factor C 140 kDa subunit) (RF-C 140 kDa subunit) (RFC140) (Replication factor C large subunit) | Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA (PubMed:9488738). This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Can bind single- or double-stranded DNA. {ECO:0000269|PubMed:8999859, ECO:0000269|PubMed:9488738}. |
| P38432 | COIL | S94 | ochoa | Coilin (p80-coilin) | Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs. {ECO:0000269|PubMed:7679389}. |
| P38935 | IGHMBP2 | S656 | ochoa | DNA-binding protein SMUBP-2 (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent helicase IGHMBP2) (Glial factor 1) (GF-1) (Immunoglobulin mu-binding protein 2) | 5' to 3' helicase that unwinds RNA and DNA duplexes in an ATP-dependent reaction (PubMed:19158098, PubMed:22999958, PubMed:30218034). Specific to 5'-phosphorylated single-stranded guanine-rich sequences (PubMed:22999958, PubMed:8349627). May play a role in RNA metabolism, ribosome biogenesis or initiation of translation (PubMed:19158098, PubMed:19299493). May play a role in regulation of transcription (By similarity). Interacts with tRNA-Tyr (PubMed:19299493). {ECO:0000250|UniProtKB:Q9EQN5, ECO:0000269|PubMed:19158098, ECO:0000269|PubMed:19299493, ECO:0000269|PubMed:22999958, ECO:0000269|PubMed:30218034, ECO:0000269|PubMed:8349627}. |
| P43681 | CHRNA4 | S362 | psp | Neuronal acetylcholine receptor subunit alpha-4 | Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators (PubMed:22361591, PubMed:27698419, PubMed:29720657, PubMed:38454578). CHRNA4 forms heteropentameric neuronal acetylcholine receptors with CHRNB2 and CHRNB4, as well as CHRNA5 and CHRNB3 as accesory subunits. Is the most abundant nAChR subtype expressed in the central nervous system (PubMed:16835356, PubMed:22361591, PubMed:27698419, PubMed:29720657, PubMed:38454578). Found in two major stoichiometric forms,(CHRNA4)3:(CHRNB2)2 and (CHRNA4)2:(CHRNB2)3, the two stoichiometric forms differ in their unitary conductance, calcium permeability, ACh sensitivity and potentiation by divalent cation (PubMed:27698419, PubMed:29720657, PubMed:38454578). Involved in the modulation of calcium-dependent signaling pathways, influences the release of neurotransmitters, including dopamine, glutamate and GABA (By similarity). {ECO:0000250|UniProtKB:O70174, ECO:0000269|PubMed:16835356, ECO:0000269|PubMed:22361591, ECO:0000269|PubMed:27698419, ECO:0000269|PubMed:29720657, ECO:0000269|PubMed:38454578}. |
| P49790 | NUP153 | S661 | ochoa | Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}. |
| P53621 | COPA | S824 | ochoa | Coatomer subunit alpha (Alpha-coat protein) (Alpha-COP) (HEP-COP) (HEPCOP) [Cleaved into: Xenin (Xenopsin-related peptide); Proxenin] | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}.; FUNCTION: Xenin stimulates exocrine pancreatic secretion. It inhibits pentagastrin-stimulated secretion of acid, to induce exocrine pancreatic secretion and to affect small and large intestinal motility. In the gut, xenin interacts with the neurotensin receptor. |
| P54296 | MYOM2 | S1191 | ochoa | Myomesin-2 (165 kDa connectin-associated protein) (165 kDa titin-associated protein) (M-protein) (Myomesin family member 2) | Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. |
| P58215 | LOXL3 | S704 | psp | Lysyl oxidase homolog 3 (EC 1.4.3.-) (EC 1.4.3.13) (Lysyl oxidase-like protein 3) | Protein-lysine 6-oxidase that mediates the oxidation of peptidyl lysine residues to allysine in target proteins (PubMed:17018530, PubMed:28065600). Catalyzes the post-translational oxidative deamination of peptidyl lysine residues in precursors of elastin and different types of collagens, a prerequisite in the formation of cross-links between collagens and elastin (PubMed:17018530). Required for somite boundary formation by catalyzing oxidation of fibronectin (FN1), enhancing integrin signaling in myofibers and their adhesion to the myotendinous junction (MTJ) (By similarity). Acts as a regulator of inflammatory response by inhibiting differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): acts by interacting with STAT3 in the nucleus and catalyzing both deacetylation and oxidation of lysine residues on STAT3, leading to disrupt STAT3 dimerization and inhibit STAT3 transcription activity (PubMed:28065600). Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated (PubMed:28065600). Also able to catalyze deacetylation of lysine residues on STAT3 (PubMed:28065600). {ECO:0000250|UniProtKB:Q9Z175, ECO:0000269|PubMed:17018530, ECO:0000269|PubMed:28065600}.; FUNCTION: [Isoform 1]: Shows protein-lysine 6-oxidase activity toward elastin and different types of collagens, with the highest activity toward collagen type VIII (PubMed:17018530). {ECO:0000269|PubMed:17018530}.; FUNCTION: [Isoform 2]: Shows protein-lysine 6-oxidase activity toward elastin and different types of collagens, with the highest activity toward collagen type IV (PubMed:17018530). {ECO:0000269|PubMed:17018530}. |
| P60484 | PTEN | S113 | psp | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.16) (EC 3.1.3.48) (EC 3.1.3.67) (Inositol polyphosphate 3-phosphatase) (EC 3.1.3.-) (Mutated in multiple advanced cancers 1) (Phosphatase and tensin homolog) | Dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins (PubMed:9187108, PubMed:9256433, PubMed:9616126). Also functions as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring of PtdIns(3,4,5)P3/phosphatidylinositol 3,4,5-trisphosphate, PtdIns(3,4)P2/phosphatidylinositol 3,4-diphosphate and PtdIns3P/phosphatidylinositol 3-phosphate with a preference for PtdIns(3,4,5)P3 (PubMed:16824732, PubMed:26504226, PubMed:9593664, PubMed:9811831). Furthermore, this enzyme can also act as a cytosolic inositol 3-phosphatase acting on Ins(1,3,4,5,6)P5/inositol 1,3,4,5,6 pentakisphosphate and possibly Ins(1,3,4,5)P4/1D-myo-inositol 1,3,4,5-tetrakisphosphate (PubMed:11418101, PubMed:15979280). Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (PubMed:31492966, PubMed:37279284). The unphosphorylated form cooperates with MAGI2 to suppress AKT1 activation (PubMed:11707428). In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement (PubMed:22279049). Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation (PubMed:22279049). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces PTEN phosphorylation which changes its binding preference from the p85 regulatory subunit of the PI3K kinase complex to DLC1 and results in translocation of the PTEN-DLC1 complex to the posterior of migrating cells to promote RHOA activation (PubMed:26166433). Meanwhile, TNS3 switches binding preference from DLC1 to p85 and the TNS3-p85 complex translocates to the leading edge of migrating cells to activate RAC1 activation (PubMed:26166433). Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Involved in the regulation of synaptic function in excitatory hippocampal synapses. Recruited to the postsynaptic membrane upon NMDA receptor activation, is required for the modulation of synaptic activity during plasticity. Enhancement of lipid phosphatase activity is able to drive depression of AMPA receptor-mediated synaptic responses, activity required for NMDA receptor-dependent long-term depression (LTD) (By similarity). May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability (PubMed:10468583, PubMed:18716620). {ECO:0000250|UniProtKB:O08586, ECO:0000250|UniProtKB:O54857, ECO:0000269|PubMed:10468583, ECO:0000269|PubMed:11418101, ECO:0000269|PubMed:11707428, ECO:0000269|PubMed:15979280, ECO:0000269|PubMed:16824732, ECO:0000269|PubMed:18716620, ECO:0000269|PubMed:22279049, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26504226, ECO:0000269|PubMed:31492966, ECO:0000269|PubMed:37279284, ECO:0000269|PubMed:9187108, ECO:0000269|PubMed:9256433, ECO:0000269|PubMed:9593664, ECO:0000269|PubMed:9616126, ECO:0000269|PubMed:9811831}.; FUNCTION: [Isoform alpha]: Functional kinase, like isoform 1 it antagonizes the PI3K-AKT/PKB signaling pathway. Plays a role in mitochondrial energetic metabolism by promoting COX activity and ATP production, via collaboration with isoform 1 in increasing protein levels of PINK1. {ECO:0000269|PubMed:23744781}. |
| P62258 | YWHAE | S117 | ochoa | 14-3-3 protein epsilon (14-3-3E) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:21189250). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35343654). Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326). Plays a positive role in the antiviral signaling pathway upstream of TBK1 via interaction with RIGI (PubMed:37555661). Mechanistically, directs RIGI redistribution from the cytosol to mitochondrial associated membranes where it mediates MAVS-dependent innate immune signaling during viral infection (PubMed:22607805). Plays a role in proliferation inhibition and cell cycle arrest by exporting HNRNPC from the nucleus to the cytoplasm to be degraded by ubiquitination (PubMed:37599448). {ECO:0000250|UniProtKB:P62261, ECO:0000269|PubMed:12917326, ECO:0000269|PubMed:21189250, ECO:0000269|PubMed:22607805, ECO:0000269|PubMed:35343654, ECO:0000269|PubMed:37555661, ECO:0000269|PubMed:37599448}. |
| P63104 | YWHAZ | S114 | ochoa | 14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:14578935, PubMed:15071501, PubMed:15644438, PubMed:16376338, PubMed:16959763, PubMed:31024343, PubMed:9360956). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35662396). Binding generally results in the modulation of the activity of the binding partner (PubMed:35662396). Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB (PubMed:35662396). Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity). {ECO:0000250|UniProtKB:O55043, ECO:0000269|PubMed:14578935, ECO:0000269|PubMed:15071501, ECO:0000269|PubMed:15644438, ECO:0000269|PubMed:16376338, ECO:0000269|PubMed:16959763, ECO:0000269|PubMed:31024343, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:9360956}. |
| P84022 | SMAD3 | S309 | psp | Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (hMAD-3) (JV15-2) (SMAD family member 3) (SMAD 3) (Smad3) (hSMAD3) | Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. {ECO:0000269|PubMed:10995748, ECO:0000269|PubMed:15241418, ECO:0000269|PubMed:15588252, ECO:0000269|PubMed:16156666, ECO:0000269|PubMed:16751101, ECO:0000269|PubMed:16862174, ECO:0000269|PubMed:17327236, ECO:0000269|PubMed:19218245, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:9732876, ECO:0000269|PubMed:9892009}. |
| Q00403 | GTF2B | S65 | psp | Transcription initiation factor IIB (EC 2.3.1.48) (General transcription factor TFIIB) (S300-II) | General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II). Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA (PubMed:12931194, PubMed:1517211, PubMed:1876184, PubMed:1946368, PubMed:27193682, PubMed:3029109, PubMed:3818643, PubMed:7601352, PubMed:8413225, PubMed:8515820, PubMed:8516311, PubMed:8516312, PubMed:9420329). Together with the TATA box-bound TBP forms the core initiation complex and provides a bridge between TBP and the Pol II-TFIIF complex (PubMed:8413225, PubMed:8504927, PubMed:8515820, PubMed:8516311, PubMed:8516312). Released from the PIC early following the onset of transcription during the initiation and elongation transition and reassociates with TBP during the next transcription cycle (PubMed:7601352). Associates with chromatin to core promoter-specific regions (PubMed:12931194, PubMed:24441171). Binds to two distinct DNA core promoter consensus sequence elements in a TBP-independent manner; these IIB-recognition elements (BREs) are localized immediately upstream (BREu), 5'-[GC][GC][GA]CGCC-3', and downstream (BREd), 5'-[GA]T[TGA][TG][GT][TG][TG]-3', of the TATA box element (PubMed:10619841, PubMed:16230532, PubMed:7675079, PubMed:9420329). Modulates transcription start site selection (PubMed:10318856). Also exhibits autoacetyltransferase activity that contributes to the activated transcription (PubMed:12931194). {ECO:0000269|PubMed:10318856, ECO:0000269|PubMed:10619841, ECO:0000269|PubMed:12931194, ECO:0000269|PubMed:1517211, ECO:0000269|PubMed:16230532, ECO:0000269|PubMed:1876184, ECO:0000269|PubMed:1946368, ECO:0000269|PubMed:24441171, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:3029109, ECO:0000269|PubMed:3818643, ECO:0000269|PubMed:7601352, ECO:0000269|PubMed:7675079, ECO:0000269|PubMed:8413225, ECO:0000269|PubMed:8504927, ECO:0000269|PubMed:8515820, ECO:0000269|PubMed:8516311, ECO:0000269|PubMed:8516312, ECO:0000269|PubMed:9420329}. |
| Q01668 | CACNA1D | S1490 | psp | Voltage-dependent L-type calcium channel subunit alpha-1D (Calcium channel, L type, alpha-1 polypeptide, isoform 2) (Voltage-gated calcium channel subunit alpha Cav1.3) | Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, and by benzothiazepines. {ECO:0000269|PubMed:21131953, ECO:0000269|PubMed:23913001, ECO:0000269|PubMed:25620733, ECO:0000269|PubMed:28472301}.; FUNCTION: [Isoform Neuronal-type]: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. {ECO:0000269|PubMed:1309651}.; FUNCTION: [Isoform 3]: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. {ECO:0000269|PubMed:18482979}.; FUNCTION: [Isoform 4]: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. {ECO:0000269|PubMed:18482979}. |
| Q03252 | LMNB2 | S168 | ochoa | Lamin-B2 | Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:33033404). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:33033404). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:33033404). {ECO:0000269|PubMed:33033404}. |
| Q06830 | PRDX1 | S152 | ochoa | Peroxiredoxin-1 (EC 1.11.1.24) (Natural killer cell-enhancing factor A) (NKEF-A) (Proliferation-associated gene protein) (PAG) (Thioredoxin peroxidase 2) (Thioredoxin-dependent peroxide reductase 2) (Thioredoxin-dependent peroxiredoxin 1) | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (PubMed:9497357). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity). {ECO:0000250|UniProtKB:P0CB50, ECO:0000269|PubMed:9497357}. |
| Q12888 | TP53BP1 | S208 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q13201 | MMRN1 | S884 | ochoa | Multimerin-1 (EMILIN-4) (Elastin microfibril interface located protein 4) (Elastin microfibril interfacer 4) (Endothelial cell multimerin) [Cleaved into: Platelet glycoprotein Ia*; 155 kDa platelet multimerin (p-155) (p155)] | Carrier protein for platelet (but not plasma) factor V/Va. Plays a role in the storage and stabilization of factor V in platelets. Upon release following platelet activation, may limit platelet and plasma factor Va-dependent thrombin generation. Ligand for integrin alpha-IIb/beta-3 and integrin alpha-V/beta-3 on activated platelets, and may function as an extracellular matrix or adhesive protein. {ECO:0000269|PubMed:16363244, ECO:0000269|PubMed:19132231, ECO:0000269|PubMed:7629143}. |
| Q13439 | GOLGA4 | S118 | ochoa | Golgin subfamily A member 4 (256 kDa golgin) (Golgin-245) (Protein 72.1) (Trans-Golgi p230) | Involved in vesicular trafficking at the Golgi apparatus level. May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1. Involved in endosome-to-Golgi trafficking (PubMed:29084197). {ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:29084197}. |
| Q14161 | GIT2 | S384 | psp | ARF GTPase-activating protein GIT2 (ARF GAP GIT2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT-2) (CAT2) (G protein-coupled receptor kinase-interactor 2) (GRK-interacting protein 2) | GTPase-activating protein for ADP ribosylation factor family members, including ARF1. {ECO:0000269|PubMed:10896954}. |
| Q14247 | CTTN | S261 | ochoa|psp | Src substrate cortactin (Amplaxin) (Oncogene EMS1) | Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). {ECO:0000250|UniProtKB:Q60598, ECO:0000250|UniProtKB:Q66HL2, ECO:0000269|PubMed:16636290, ECO:0000269|PubMed:17959782, ECO:0000269|PubMed:21296879, ECO:0000269|PubMed:23144454}. |
| Q14653 | IRF3 | S97 | psp | Interferon regulatory factor 3 (IRF-3) | Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses (PubMed:22394562, PubMed:24049179, PubMed:25636800, PubMed:27302953, PubMed:31340999, PubMed:36603579, PubMed:8524823). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:11846977, PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:32972995, PubMed:36603579, PubMed:8524823). Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction (PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:36603579). Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases (PubMed:22394562, PubMed:25636800, PubMed:27302953, PubMed:36603579). This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes (PubMed:16154084, PubMed:27302953, PubMed:33440148, PubMed:36603579). Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages (PubMed:16846591). In response to Sendai virus infection, is recruited by TOMM70:HSP90AA1 to mitochondrion and forms an apoptosis complex TOMM70:HSP90AA1:IRF3:BAX inducing apoptosis (PubMed:25609812). Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000269|PubMed:16154084, ECO:0000269|PubMed:22394562, ECO:0000269|PubMed:24049179, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27302953, ECO:0000269|PubMed:31340999, ECO:0000269|PubMed:31413131, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:33440148, ECO:0000269|PubMed:36603579, ECO:0000269|PubMed:8524823, ECO:0000303|PubMed:11846977, ECO:0000303|PubMed:16846591, ECO:0000303|PubMed:16979567, ECO:0000303|PubMed:20049431}. |
| Q14677 | CLINT1 | S282 | ochoa | Clathrin interactor 1 (Clathrin-interacting protein localized in the trans-Golgi region) (Clint) (Enthoprotin) (Epsin-4) (Epsin-related protein) (EpsinR) | Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly. {ECO:0000269|PubMed:12429846, ECO:0000269|PubMed:12538641}. |
| Q14919 | DRAP1 | S89 | ochoa | Dr1-associated corepressor (Dr1-associated protein 1) (Negative cofactor 2-alpha) (NC2-alpha) | The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. {ECO:0000269|PubMed:8608938, ECO:0000269|PubMed:8670811}. |
| Q15643 | TRIP11 | S1335 | ochoa | Thyroid receptor-interacting protein 11 (TR-interacting protein 11) (TRIP-11) (Clonal evolution-related gene on chromosome 14 protein) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) | Is a membrane tether required for vesicle tethering to Golgi. Has an essential role in the maintenance of Golgi structure and function (PubMed:25473115, PubMed:30728324). It is required for efficient anterograde and retrograde trafficking in the early secretory pathway, functioning at both the ER-to-Golgi intermediate compartment (ERGIC) and Golgi complex (PubMed:25717001). Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription. {ECO:0000269|PubMed:10189370, ECO:0000269|PubMed:25473115, ECO:0000269|PubMed:25717001, ECO:0000269|PubMed:30728324, ECO:0000269|PubMed:9256431}. |
| Q53QZ3 | ARHGAP15 | S217 | ochoa | Rho GTPase-activating protein 15 (ArhGAP15) (Rho-type GTPase-activating protein 15) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction. {ECO:0000269|PubMed:12650940}. |
| Q5QJE6 | DNTTIP2 | S569 | ochoa | Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) | Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}. |
| Q5S007 | LRRK2 | S1292 | psp | Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin) | Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking (PubMed:17114044, PubMed:20949042, PubMed:21850687, PubMed:22012985, PubMed:23395371, PubMed:24687852, PubMed:25201882, PubMed:26014385, PubMed:26824392, PubMed:27830463, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB29, RAB35, and RAB43 (PubMed:23395371, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421, PubMed:38127736). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PubMed:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (PubMed:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:17114044). Plays a role in synaptic vesicle trafficking (PubMed:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PubMed:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PubMed:22012985). Phosphorylates PRDX3 (PubMed:21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Acts as a positive regulator of innate immunity by mediating phosphorylation of RIPK2 downstream of NOD1 and NOD2, thereby enhancing RIPK2 activation (PubMed:27830463). Independent of its kinase activity, inhibits the proteasomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PubMed:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PubMed:18230735, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29212815). Recruited by RAB29/RAB7L1 to overloaded lysosomes where it phosphorylates and stabilizes RAB8A and RAB10 which promote lysosomal content release and suppress lysosomal enlargement through the EHBP1 and EHBP1L1 effector proteins (PubMed:30209220, PubMed:38227290). {ECO:0000269|PubMed:17114044, ECO:0000269|PubMed:18230735, ECO:0000269|PubMed:20949042, ECO:0000269|PubMed:21850687, ECO:0000269|PubMed:22012985, ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:24687852, ECO:0000269|PubMed:25201882, ECO:0000269|PubMed:26014385, ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:27830463, ECO:0000269|PubMed:28720718, ECO:0000269|PubMed:29125462, ECO:0000269|PubMed:29127255, ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:30209220, ECO:0000269|PubMed:30398148, ECO:0000269|PubMed:30635421, ECO:0000269|PubMed:38127736, ECO:0000269|PubMed:38227290}. |
| Q5T0W9 | FAM83B | S664 | ochoa | Protein FAM83B | Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades. {ECO:0000269|PubMed:22886302, ECO:0000269|PubMed:23676467, ECO:0000269|PubMed:23912460}. |
| Q5T5C0 | STXBP5 | S1131 | ochoa | Syntaxin-binding protein 5 (Lethal(2) giant larvae protein homolog 3) (Tomosyn-1) | Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane. Competes with STXBP1 for STX1 binding (By similarity). {ECO:0000250}. |
| Q5T9A4 | ATAD3B | S120 | ochoa | ATPase family AAA domain-containing protein 3B (AAA-TOB3) | May play a role in a mitochondrial network organization typical for stem cells, characterized by reduced mitochondrial metabolism, low mtDNA copies and fragmentated mitochondrial network. May act by suppressing ATAD3A function, interfering with ATAD3A interaction with matrix nucleoid complexes. {ECO:0000269|PubMed:22664726}. |
| Q5T9C2 | EEIG1 | S311 | ochoa | Early estrogen-induced gene 1 protein (EEIG1) | Key component of TNFSF11/RANKL- and TNF-induced osteoclastogenesis pathways, thereby mediates bone resorption in pathological bone loss conditions (By similarity). Required for TNFSF11/RANKL-induced osteoclastogenesis via its interaction with TNFRSF11A/RANK, thereby facilitates the downsteam transcription of NFATC1 and activation of PLCG2 (By similarity). Facilitates recruitment of the transcriptional repressor PRDM1/BLIMP1 to the promoter of the anti-osteoclastogenesis gene IRF8, thereby resulting in transcription of osteoclast differentiation factors (By similarity). May play a role in estrogen action (PubMed:14605097). {ECO:0000250|UniProtKB:Q78T81, ECO:0000269|PubMed:14605097}. |
| Q5VWJ9 | SNX30 | S37 | ochoa | Sorting nexin-30 | Involved in the regulation of endocytosis and in several stages of intracellular trafficking (PubMed:32513819). Together with SNX4, involved in autophagosome assembly (PubMed:32513819). {ECO:0000269|PubMed:32513819}. |
| Q5VWN6 | TASOR2 | S1025 | ochoa | Protein TASOR 2 | None |
| Q5W0B1 | OBI1 | S416 | ochoa | ORC ubiquitin ligase 1 (OBI1) (EC 2.3.2.27) (RING finger protein 219) | E3 ubiquitin ligase essential for DNA replication origin activation during S phase (PubMed:31160578). Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase (PubMed:31160578). {ECO:0000269|PubMed:31160578}. |
| Q6ZTQ3 | RASSF6 | S157 | ochoa | Ras association domain-containing protein 6 | Involved in the induction of apoptosis, through both caspase-dependent and caspase-independent pathways. May act as a Ras effector protein. May suppress the serum-induced basal levels of NF-kappa-B (By similarity). {ECO:0000250, ECO:0000269|PubMed:17367779}. |
| Q70CQ2 | USP34 | S1751 | psp | Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.4.19.12) (Deubiquitinating enzyme 34) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) | Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. {ECO:0000269|PubMed:21383061}. |
| Q7Z417 | NUFIP2 | S250 | ochoa | FMR1-interacting protein NUFIP2 (82 kDa FMRP-interacting protein) (82-FIP) (Cell proliferation-inducing gene 1 protein) (FMRP-interacting protein 2) (Nuclear FMR1-interacting protein 2) | Binds RNA. {ECO:0000269|PubMed:12837692}. |
| Q7Z591 | AKNA | S579 | ochoa | Microtubule organization protein AKNA (AT-hook-containing transcription factor) | Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (By similarity). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (By similarity). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (By similarity). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (By similarity). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (PubMed:11268217). Binds to A/T-rich promoters (PubMed:11268217). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable). {ECO:0000250|UniProtKB:Q80VW7, ECO:0000269|PubMed:11268217, ECO:0000305}. |
| Q8IVL1 | NAV2 | S79 | ochoa | Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2) | Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs. {ECO:0000269|PubMed:12214280, ECO:0000269|PubMed:15158073}. |
| Q8IXJ9 | ASXL1 | S48 | ochoa | Polycomb group protein ASXL1 (Additional sex combs-like protein 1) | Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG) (PubMed:16606617). Acts as a coactivator of RARA and RXRA through association with NCOA1 (PubMed:16606617). Acts as a corepressor for PPARG and suppresses its adipocyte differentiation-inducing activity (By similarity). Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (PubMed:20436459, PubMed:30664650, PubMed:36180891). Acts as a sensor of N(6)-methyladenine methylation on DNA (6mA): recognizes and binds 6mA DNA, leading to its ubiquitination and degradation by TRIP12, thereby inactivating the PR-DUB complex and regulating Polycomb silencing (PubMed:30982744). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:30664650, PubMed:36180891). ASXL1, ASXL2 and ASXL3 function redundantly in the PR-DUB complex (By similarity) (PubMed:30664650). The ASXL proteins are essential for chromatin recruitment and transcriptional activation of associated genes (By similarity). ASXL1 and ASXL2 are important for BAP1 protein stability (PubMed:30664650). Together with BAP1, negatively regulates epithelial-mesenchymal transition (EMT) of trophoblast stem cells during placental development by regulating genes involved in epithelial cell integrity, cell adhesion and cytoskeletal organization (PubMed:34170818). {ECO:0000250|UniProtKB:P59598, ECO:0000269|PubMed:16606617, ECO:0000269|PubMed:20436459, ECO:0000269|PubMed:30664650, ECO:0000269|PubMed:30982744, ECO:0000269|PubMed:34170818, ECO:0000269|PubMed:36180891}. |
| Q8IY92 | SLX4 | S1204 | ochoa | Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) | Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. {ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19595722, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}. |
| Q8N122 | RPTOR | S696 | ochoa|psp | Regulatory-associated protein of mTOR (Raptor) (p150 target of rapamycin (TOR)-scaffold protein) | Component of the mechanistic target of rapamycin complex 1 (mTORC1), an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:26588989, PubMed:32561715, PubMed:37541260). In response to nutrients, growth factors or amino acids, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating several substrates, such as ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:26588989, PubMed:37541260). In the same time, it inhibits catabolic pathways by phosphorylating the autophagy initiation components ULK1 and ATG13, as well as transcription factor TFEB, a master regulators of lysosomal biogenesis and autophagy (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:32561715, PubMed:37541260). The mTORC1 complex is inhibited in response to starvation and amino acid depletion (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:37541260). Within the mTORC1 complex, RPTOR acts both as a molecular adapter, which (1) mediates recruitment of mTORC1 to lysosomal membranes via interaction with small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD), and a (2) substrate-specific adapter, which promotes substrate specificity by binding to TOS motif-containing proteins and direct them towards the active site of the MTOR kinase domain for phosphorylation (PubMed:12747827, PubMed:24403073, PubMed:26588989, PubMed:37541260). mTORC1 complex regulates many cellular processes, such as odontoblast and osteoclast differentiation or neuronal transmission (By similarity). mTORC1 complex in excitatory neuronal transmission is required for the prosocial behavior induced by the psychoactive substance lysergic acid diethylamide (LSD) (By similarity). {ECO:0000250|UniProtKB:Q8K4Q0, ECO:0000269|PubMed:12150925, ECO:0000269|PubMed:12150926, ECO:0000269|PubMed:12747827, ECO:0000269|PubMed:24403073, ECO:0000269|PubMed:26588989, ECO:0000269|PubMed:32561715, ECO:0000269|PubMed:37541260}. |
| Q8N568 | DCLK2 | S682 | ochoa | Serine/threonine-protein kinase DCLK2 (EC 2.7.11.1) (CaMK-like CREB regulatory kinase 2) (CL2) (CLICK-II) (CLICK2) (Doublecortin domain-containing protein 3B) (Doublecortin-like and CAM kinase-like 2) (Doublecortin-like kinase 2) | Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity). {ECO:0000250}. |
| Q8NHG8 | ZNRF2 | S193 | ochoa | E3 ubiquitin-protein ligase ZNRF2 (EC 2.3.2.27) (Protein Ells2) (RING finger protein 202) (RING-type E3 ubiquitin transferase ZNRF2) (Zinc/RING finger protein 2) | E3 ubiquitin-protein ligase that plays a role in the establishment and maintenance of neuronal transmission and plasticity. Ubiquitinates the Na(+)/K(+) ATPase alpha-1 subunit/ATP1A1 and thereby influences its endocytosis and/or degradation (PubMed:22797923). Acts also as a positive regulator of mTORC1 activation by amino acids, which functions upstream of the V-ATPase and of Rag-GTPases (PubMed:27244671). In turn, phosphorylation by mTOR leads to its inhibition via targeting to the cytosol allowing a self-regulating feedback mechanism (PubMed:27244671). {ECO:0000269|PubMed:14561866, ECO:0000269|PubMed:22797923, ECO:0000269|PubMed:27244671}. |
| Q8TAQ2 | SMARCC2 | S69 | ochoa | SWI/SNF complex subunit SMARCC2 (BRG1-associated factor 170) (BAF170) (SWI/SNF complex 170 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:11018012). Can stimulate the ATPase activity of the catalytic subunit of these complexes (PubMed:10078207). May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells (PubMed:12192000). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation (By similarity). {ECO:0000250|UniProtKB:Q6PDG5, ECO:0000269|PubMed:10078207, ECO:0000269|PubMed:11018012, ECO:0000269|PubMed:12192000, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q8TC05 | MDM1 | S314 | ochoa | Nuclear protein MDM1 | Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules (PubMed:26337392). {ECO:0000269|PubMed:26337392}. |
| Q8WVJ2 | NUDCD2 | S137 | ochoa | NudC domain-containing protein 2 | May regulate the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone. {ECO:0000269|PubMed:20133715}. |
| Q92499 | DDX1 | S671 | psp | ATP-dependent RNA helicase DDX1 (EC 3.6.4.13) (DEAD box protein 1) (DEAD box protein retinoblastoma) (DBP-RB) | Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 expression. Binds to the cyclin CCND2 promoter region. Associates with chromatin at the NF-kappa-B promoter region via association with RELA. Binds to poly(A) RNA. May be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB: together with archease (ZBTB8OS), acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation (PubMed:24870230). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1. Specifically binds (via helicase ATP-binding domain) on both short and long poly(I:C) dsRNA (By similarity). {ECO:0000250|UniProtKB:Q91VR5, ECO:0000269|PubMed:12183465, ECO:0000269|PubMed:15567440, ECO:0000269|PubMed:18335541, ECO:0000269|PubMed:18710941, ECO:0000269|PubMed:20573827, ECO:0000269|PubMed:24870230}.; FUNCTION: (Microbial infection) Required for HIV-1 Rev function as well as for HIV-1 and coronavirus IBV replication. Binds to the RRE sequence of HIV-1 mRNAs. {ECO:0000269|PubMed:15567440}.; FUNCTION: (Microbial infection) Required for Coronavirus IBV replication. {ECO:0000269|PubMed:20573827}. |
| Q93009 | USP7 | S967 | ochoa | Ubiquitin carboxyl-terminal hydrolase 7 (EC 3.4.19.12) (Deubiquitinating enzyme 7) (Herpesvirus-associated ubiquitin-specific protease) (Ubiquitin thioesterase 7) (Ubiquitin-specific-processing protease 7) | Hydrolase that deubiquitinates target proteins such as ARMC5, FOXO4, DEPTOR, KAT5, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN, KMT2E/MLL5 and DAXX (PubMed:11923872, PubMed:15053880, PubMed:16964248, PubMed:18716620, PubMed:25283148, PubMed:25865756, PubMed:26678539, PubMed:28655758, PubMed:33544460, PubMed:35216969). Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation (PubMed:15053880, PubMed:16845383, PubMed:18566590, PubMed:20153724). Deubiquitinates p53/TP53, preventing degradation of p53/TP53, and enhances p53/TP53-dependent transcription regulation, cell growth repression and apoptosis (PubMed:25283148). Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53-dependent cell growth repression and apoptosis (PubMed:11923872, PubMed:26786098). Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity (PubMed:16964248). In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML (PubMed:18716620). Deubiquitinates KMT2E/MLL5 preventing KMT2E/MLL5 proteasomal-mediated degradation (PubMed:26678539). Involved in cell proliferation during early embryonic development. Involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage: recruited to DNA damage sites following interaction with KIAA1530/UVSSA and promotes deubiquitination of ERCC6, preventing UV-induced degradation of ERCC6 (PubMed:22466611, PubMed:22466612). Involved in maintenance of DNA methylation via its interaction with UHRF1 and DNMT1: acts by mediating deubiquitination of UHRF1 and DNMT1, preventing their degradation and promoting DNA methylation by DNMT1 (PubMed:21745816, PubMed:22411829). Deubiquitinates alkylation repair enzyme ALKBH3. OTUD4 recruits USP7 and USP9X to stabilize ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111). Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex (PubMed:20601937). Able to mediate deubiquitination of histone H2B; it is however unsure whether this activity takes place in vivo (PubMed:20601937). Exhibits a preference towards 'Lys-48'-linked ubiquitin chains (PubMed:22689415). Increases regulatory T-cells (Treg) suppressive capacity by deubiquitinating and stabilizing the transcription factor FOXP3 which is crucial for Treg cell function (PubMed:23973222). Plays a role in the maintenance of the circadian clock periodicity via deubiquitination and stabilization of the CRY1 and CRY2 proteins (PubMed:27123980). Deubiquitinates REST, thereby stabilizing REST and promoting the maintenance of neural progenitor cells (PubMed:21258371). Deubiquitinates SIRT7, inhibiting SIRT7 histone deacetylase activity and regulating gluconeogenesis (PubMed:28655758). Involved in the regulation of WASH-dependent actin polymerization at the surface of endosomes and the regulation of endosomal protein recycling (PubMed:26365382). It maintains optimal WASH complex activity and precise F-actin levels via deubiquitination of TRIM27 and WASHC1 (PubMed:26365382). Mediates the deubiquitination of phosphorylated DEPTOR, promoting its stability and leading to decreased mTORC1 signaling (PubMed:35216969). {ECO:0000269|PubMed:11923872, ECO:0000269|PubMed:15053880, ECO:0000269|PubMed:16845383, ECO:0000269|PubMed:16964248, ECO:0000269|PubMed:18566590, ECO:0000269|PubMed:18716620, ECO:0000269|PubMed:20153724, ECO:0000269|PubMed:20601937, ECO:0000269|PubMed:21258371, ECO:0000269|PubMed:21745816, ECO:0000269|PubMed:22411829, ECO:0000269|PubMed:22466611, ECO:0000269|PubMed:22466612, ECO:0000269|PubMed:22689415, ECO:0000269|PubMed:23973222, ECO:0000269|PubMed:25283148, ECO:0000269|PubMed:25865756, ECO:0000269|PubMed:25944111, ECO:0000269|PubMed:26365382, ECO:0000269|PubMed:26678539, ECO:0000269|PubMed:26786098, ECO:0000269|PubMed:27123980, ECO:0000269|PubMed:28655758, ECO:0000269|PubMed:33544460, ECO:0000269|PubMed:35216969}.; FUNCTION: (Microbial infection) Contributes to the overall stabilization and trans-activation capability of the herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 during HSV-1 infection. {ECO:0000269|PubMed:14506283, ECO:0000269|PubMed:16160161, ECO:0000269|PubMed:18590780}.; FUNCTION: (Microbial infection) Upon infection with Epstein-Barr virus, the interaction with viral EBNA1 increases the association of USP7 with PML proteins, which is required for the polyubiquitylation and degradation of PML. {ECO:0000269|PubMed:20719947, ECO:0000269|PubMed:24216761}. |
| Q96MT8 | CEP63 | S437 | ochoa | Centrosomal protein of 63 kDa (Cep63) | Required for normal spindle assembly (PubMed:21406398, PubMed:21983783, PubMed:26297806, PubMed:35793002). Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:21983783, PubMed:26297806). Reported to be required for centrosomal recruitment of CEP152; however, this function has been questioned (PubMed:21983783, PubMed:26297806). Also recruits CDK1 to centrosomes (PubMed:21406398). Plays a role in DNA damage response (PubMed:21406398). Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (PubMed:21406398). Promotes stabilization of FXR1 protein by inhibiting FXR1 ubiquitination (PubMed:35989368). {ECO:0000269|PubMed:21406398, ECO:0000269|PubMed:21983783, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:35793002, ECO:0000269|PubMed:35989368}. |
| Q96QK1 | VPS35 | S759 | ochoa | Vacuolar protein sorting-associated protein 35 (hVPS35) (Maternal-embryonic 3) (Vesicle protein sorting 35) | Acts as a component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The CSC seems to associate with the cytoplasmic domain of cargo proteins predominantly via VPS35; however, these interactions seem to be of low affinity and retromer SNX proteins may also contribute to cargo selectivity thus questioning the classical function of the CSC. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway (PubMed:30213940). The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (Probable). Required for retrograde transport of lysosomal enzyme receptor IGF2R and SLC11A2. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (PubMed:15078903, PubMed:15247922, PubMed:20164305). Required for endosomal localization of WASHC2C (PubMed:22070227, PubMed:28892079). Mediates the association of the CSC with the WASH complex via WASHC2 (PubMed:22070227, PubMed:24819384, PubMed:24980502). Required for the endosomal localization of TBC1D5 (PubMed:20923837). {ECO:0000269|PubMed:15078903, ECO:0000269|PubMed:15247922, ECO:0000269|PubMed:20164305, ECO:0000269|PubMed:20923837, ECO:0000269|PubMed:22070227, ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:24819384, ECO:0000269|PubMed:24980502, ECO:0000269|PubMed:28892079, ECO:0000269|PubMed:30213940, ECO:0000303|PubMed:21725319, ECO:0000303|PubMed:22070227, ECO:0000303|PubMed:22513087, ECO:0000303|PubMed:23563491}.; FUNCTION: (Microbial infection) The heterotrimeric retromer cargo-selective complex (CSC) mediates the exit of human papillomavirus from the early endosome and the delivery to the Golgi apparatus. {ECO:0000269|PubMed:25693203, ECO:0000269|PubMed:30122350}. |
| Q96S38 | RPS6KC1 | S866 | ochoa | Ribosomal protein S6 kinase delta-1 (S6K-delta-1) (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein) | May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell (PubMed:12077123). Plays a role in the recruitment of PRDX3 to early endosomes (PubMed:15750338). {ECO:0000269|PubMed:12077123, ECO:0000269|PubMed:15750338}. |
| Q99081 | TCF12 | S534 | ochoa | Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) | Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250|UniProtKB:Q61286, ECO:0000269|PubMed:32620954}. |
| Q9BPX3 | NCAPG | S818 | ochoa | Condensin complex subunit 3 (Chromosome-associated protein G) (Condensin subunit CAP-G) (hCAP-G) (Melanoma antigen NY-MEL-3) (Non-SMC condensin I complex subunit G) (XCAP-G homolog) | Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. {ECO:0000269|PubMed:11136719}. |
| Q9BRY0 | SLC39A3 | S114 | ochoa | Zinc transporter ZIP3 (Solute carrier family 39 member 3) (Zrt- and Irt-like protein 3) (ZIP-3) | Transporter for the divalent cation Zn(2+). Mediates the influx of Zn(2+) into cells from extracellular space. Controls Zn(2+) accumulation into dentate gyrus granule cells in the hippocampus. Mediates Zn(2+) reuptake from the secreted milk within the alveolar lumen. {ECO:0000250|UniProtKB:Q99K24}. |
| Q9BXW9 | FANCD2 | S64 | psp | Fanconi anemia group D2 protein (Protein FACD2) | Required for maintenance of chromosomal stability (PubMed:11239453, PubMed:14517836). Promotes accurate and efficient pairing of homologs during meiosis (PubMed:14517836). Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing (PubMed:15671039, PubMed:15650050, PubMed:30335751, PubMed:36385258). The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA (By similarity). May participate in S phase and G2 phase checkpoint activation upon DNA damage (PubMed:15377654). Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress (PubMed:15454491, PubMed:15661754). Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress (PubMed:15661754, PubMed:19465921). Promotes BRCA2/FANCD1 loading onto damaged chromatin (PubMed:11239454, PubMed:12239151, PubMed:12086603, PubMed:15115758, PubMed:15199141, PubMed:15671039, PubMed:18212739). May also be involved in B-cell immunoglobulin isotype switching. {ECO:0000250|UniProtKB:Q68Y81, ECO:0000269|PubMed:11239453, ECO:0000269|PubMed:11239454, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12239151, ECO:0000269|PubMed:14517836, ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15314022, ECO:0000269|PubMed:15377654, ECO:0000269|PubMed:15454491, ECO:0000269|PubMed:15650050, ECO:0000269|PubMed:15661754, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:19465921, ECO:0000269|PubMed:30335751, ECO:0000269|PubMed:36385258}. |
| Q9C040 | TRIM2 | S370 | ochoa | Tripartite motif-containing protein 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM2) (RING finger protein 86) (RING-type E3 ubiquitin transferase TRIM2) | UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance. Plays a role in antiviral immunity and limits New World arenavirus infection independently of its ubiquitin ligase activity (PubMed:24068738). {ECO:0000250|UniProtKB:Q9ESN6, ECO:0000269|PubMed:24068738}. |
| Q9C0C2 | TNKS1BP1 | S899 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9H0U9 | TSPYL1 | S26 | ochoa | Testis-specific Y-encoded-like protein 1 (TSPY-like protein 1) | None |
| Q9H3H1 | TRIT1 | S167 | ochoa | tRNA dimethylallyltransferase (EC 2.5.1.75) (Isopentenyl-diphosphate:tRNA isopentenyltransferase) (IPP transferase) (IPPT) (hGRO1) (tRNA isopentenyltransferase 1) (IPTase) | Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i6A37) (PubMed:11111046, PubMed:24126054, PubMed:24901367, PubMed:34774131). Mediates modification of a limited subset of tRNAs: tRNA(Ser)(AGA), tRNA(Ser)(CGA), tRNA(Ser)(UGA), as well as partial modification of the selenocysteine tRNA(Ser)(UCA) (PubMed:24126054). TRIT1 is therefore required for selenoprotein expression (PubMed:24126054). {ECO:0000269|PubMed:11111046, ECO:0000269|PubMed:24126054, ECO:0000269|PubMed:24901367, ECO:0000269|PubMed:34774131}. |
| Q9H4Z2 | ZNF335 | S416 | ochoa | Zinc finger protein 335 (NRC-interacting factor 1) (NIF-1) | Component or associated component of some histone methyltransferase complexes may regulate transcription through recruitment of those complexes on gene promoters (PubMed:19131338, PubMed:23178126). Enhances ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:12215545, PubMed:18180299, PubMed:19131338). Plays an important role in neural progenitor cell proliferation and self-renewal through the regulation of specific genes involved brain development, including REST (PubMed:23178126). Also controls the expression of genes involved in somatic development and regulates, for instance, lymphoblast proliferation (PubMed:23178126). {ECO:0000269|PubMed:12215545, ECO:0000269|PubMed:18180299, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:23178126}. |
| Q9H6U6 | BCAS3 | S850 | ochoa | BCAS3 microtubule associated cell migration factor (Breast carcinoma-amplified sequence 3) (GAOB1) | Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation (By similarity). Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin. Plays a regulatory role in autophagic activity. In complex with PHAF1, associates with the preautophagosomal structure during both non-selective and selective autophagy (PubMed:33499712). Probably binds phosphatidylinositol 3-phosphate (PtdIns3P) which would mediate the recruitment preautophagosomal structures (PubMed:33499712). {ECO:0000250|UniProtKB:Q8CCN5, ECO:0000269|PubMed:17505058, ECO:0000269|PubMed:33499712}. |
| Q9H9A7 | RMI1 | S456 | ochoa | RecQ-mediated genome instability protein 1 (BLM-associated protein of 75 kDa) (BLAP75) (FAAP75) | Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability. {ECO:0000269|PubMed:15775963, ECO:0000269|PubMed:16537486, ECO:0000269|PubMed:16595695}. |
| Q9HCD6 | TANC2 | S252 | ochoa | Protein TANC2 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2) | Scaffolding protein in the dendritic spines which acts as immobile postsynaptic posts able to recruit KIF1A-driven dense core vesicles to dendritic spines. {ECO:0000269|PubMed:30021165}. |
| Q9HCH5 | SYTL2 | S540 | ochoa | Synaptotagmin-like protein 2 (Breast cancer-associated antigen SGA-72M) (Exophilin-4) | Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive. {ECO:0000269|PubMed:17182843, ECO:0000269|PubMed:18266782, ECO:0000269|PubMed:18812475}. |
| Q9NRD5 | PICK1 | S342 | psp | PRKCA-binding protein (Protein interacting with C kinase 1) (Protein kinase C-alpha-binding protein) | Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function. {ECO:0000269|PubMed:20403402}. |
| Q9NRN7 | AASDHPPT | S258 | ochoa | L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase (EC 2.7.8.7) (4'-phosphopantetheinyl transferase) (Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase) (AASD-PPT) (LYS5 ortholog) | Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'-phosphopantetheine moiety from coenzyme A, regardless of whether the CoA is presented in the free thiol form or as an acetyl thioester, to a serine residue of a broad range of acceptors including the acyl carrier domain of FASN. {ECO:0000269|PubMed:11286508, ECO:0000269|PubMed:12815048, ECO:0000269|PubMed:18022563, ECO:0000269|PubMed:19933275, ECO:0000269|PubMed:21238436}. |
| Q9NSY1 | BMP2K | S1064 | ochoa | BMP-2-inducible protein kinase (BIKe) (EC 2.7.11.1) | May be involved in osteoblast differentiation. {ECO:0000250|UniProtKB:Q91Z96}. |
| Q9NUY8 | TBC1D23 | S507 | ochoa | TBC1 domain family member 23 (HCV non-structural protein 4A-transactivated protein 1) | Putative Rab GTPase-activating protein which plays a role in vesicular trafficking (PubMed:28823707). Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles (PubMed:29084197, PubMed:29426865). Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP-1 (PubMed:29426865). Plays a role in brain development, including in cortical neuron positioning (By similarity). May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes that are essential for axonal and dendritic growth (By similarity). May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge (By similarity). {ECO:0000250|UniProtKB:Q8K0F1, ECO:0000269|PubMed:28823707, ECO:0000269|PubMed:29084197, ECO:0000269|PubMed:29426865}. |
| Q9NVI7 | ATAD3A | S168 | ochoa | ATPase family AAA domain-containing protein 3A (EC 3.6.1.-) | Essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organism and cellular level (PubMed:17210950, PubMed:20154147, PubMed:22453275, PubMed:31522117, PubMed:37832546, PubMed:39116259). May play an important role in mitochondrial protein synthesis (PubMed:22453275). May also participate in mitochondrial DNA replication (PubMed:17210950). May bind to mitochondrial DNA D-loops and contribute to nucleoid stability (PubMed:17210950). Required for enhanced channeling of cholesterol for hormone-dependent steroidogenesis (PubMed:22453275). Involved in mitochondrial-mediated antiviral innate immunity (PubMed:31522117). Required to protect mitochondria from the PERK-mediated unfolded protein response: specifically inhibits the activity of EIF2AK3/PERK at mitochondria-endoplasmic reticulum contact sites, thereby providing a safe haven for mitochondrial protein translation during endoplasmic reticulum stress (PubMed:39116259). Ability to inhibit EIF2AK3/PERK is independent of its ATPase activity (PubMed:39116259). Also involved in the mitochondrial DNA damage response by promoting signaling between damaged genomes and the mitochondrial membrane, leading to activation of the integrated stress response (ISR) (PubMed:37832546). {ECO:0000269|PubMed:17210950, ECO:0000269|PubMed:20154147, ECO:0000269|PubMed:22453275, ECO:0000269|PubMed:31522117, ECO:0000269|PubMed:37832546, ECO:0000269|PubMed:39116259}. |
| Q9P2D1 | CHD7 | S2490 | ochoa | Chromodomain-helicase-DNA-binding protein 7 (CHD-7) (EC 3.6.4.-) (ATP-dependent helicase CHD7) | ATP-dependent chromatin-remodeling factor, slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Probable transcription regulator. May be involved in the in 45S precursor rRNA production. {ECO:0000269|PubMed:22646239, ECO:0000269|PubMed:28533432}. |
| Q9UBU7 | DBF4 | S508 | ochoa | Protein DBF4 homolog A (Activator of S phase kinase) (Chiffon homolog A) (DBF4-type zinc finger-containing protein 1) | Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle. {ECO:0000269|PubMed:10373557, ECO:0000269|PubMed:10523313, ECO:0000269|PubMed:17062569}. |
| Q9UBW5 | BIN2 | S508 | ochoa | Bridging integrator 2 (Breast cancer-associated protein 1) | Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis. {ECO:0000269|PubMed:23285027}. |
| Q9UP95 | SLC12A4 | S24 | ochoa | Solute carrier family 12 member 4 (Electroneutral potassium-chloride cotransporter 1) (Erythroid K-Cl cotransporter 1) (hKCC1) | Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:35759661). May contribute to cell volume homeostasis in single cells (PubMed:10913127, PubMed:34031912). May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity). {ECO:0000250|UniProtKB:Q9JIS8, ECO:0000269|PubMed:10913127, ECO:0000269|PubMed:34031912, ECO:0000269|PubMed:35759661}.; FUNCTION: [Isoform 4]: No transporter activity. {ECO:0000269|PubMed:11551954}. |
| Q9UP95 | SLC12A4 | S973 | ochoa | Solute carrier family 12 member 4 (Electroneutral potassium-chloride cotransporter 1) (Erythroid K-Cl cotransporter 1) (hKCC1) | Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:35759661). May contribute to cell volume homeostasis in single cells (PubMed:10913127, PubMed:34031912). May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity). {ECO:0000250|UniProtKB:Q9JIS8, ECO:0000269|PubMed:10913127, ECO:0000269|PubMed:34031912, ECO:0000269|PubMed:35759661}.; FUNCTION: [Isoform 4]: No transporter activity. {ECO:0000269|PubMed:11551954}. |
| Q9Y2X9 | ZNF281 | S620 | ochoa | Zinc finger protein 281 (GC-box-binding zinc finger protein 1) (Transcription factor ZBP-99) (Zinc finger DNA-binding protein 99) | Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs (By similarity). Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes. {ECO:0000250, ECO:0000269|PubMed:10448078, ECO:0000269|PubMed:12771217}. |
| Q9Y365 | STARD10 | S250 | ochoa | START domain-containing protein 10 (StARD10) (Antigen NY-CO-28) (PCTP-like protein) (PCTP-L) (Serologically defined colon cancer antigen 28) (StAR-related lipid transfer protein 10) | May play metabolic roles in sperm maturation or fertilization (By similarity). Phospholipid transfer protein that preferentially selects lipid species containing a palmitoyl or stearoyl chain on the sn-1 and an unsaturated fatty acyl chain (18:1 or 18:2) on the sn-2 position. Able to transfer phosphatidylcholine (PC) and phosphatidyetanolamline (PE) between membranes. {ECO:0000250, ECO:0000269|PubMed:15911624}. |
| Q9Y5S2 | CDC42BPB | S1527 | ochoa | Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (CDC42BP-beta) (DMPK-like beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (MRCK beta) (Myotonic dystrophy protein kinase-like beta) | Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715, PubMed:21949762). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates PPP1R12A (PubMed:21457715). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). {ECO:0000250|UniProtKB:Q7TT50, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:21949762}. |
| O00418 | EEF2K | S135 | Sugiyama | Eukaryotic elongation factor 2 kinase (eEF-2 kinase) (eEF-2K) (EC 2.7.11.20) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase) | Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced. {ECO:0000269|PubMed:14709557, ECO:0000269|PubMed:9144159}. |
| P84098 | RPL19 | S37 | Sugiyama | Large ribosomal subunit protein eL19 (60S ribosomal protein L19) | Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| Q13283 | G3BP1 | S67 | Sugiyama | Ras GTPase-activating protein-binding protein 1 (G3BP-1) (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent DNA helicase VIII) (hDH VIII) (GAP SH3 domain-binding protein 1) | Protein involved in various processes, such as stress granule formation and innate immunity (PubMed:12642610, PubMed:20180778, PubMed:23279204, PubMed:30510222, PubMed:30804210). Plays an essential role in stress granule formation (PubMed:12642610, PubMed:20180778, PubMed:23279204, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:34739333, PubMed:35977029, PubMed:36183834, PubMed:36279435, PubMed:36692217, PubMed:37379838). Stress granules are membraneless compartments that store mRNAs and proteins, such as stalled translation pre-initiation complexes, in response to stress (PubMed:12642610, PubMed:20180778, PubMed:23279204, PubMed:27022092, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:36279435, PubMed:37379838). Promotes formation of stress granules phase-separated membraneless compartment by undergoing liquid-liquid phase separation (LLPS) upon unfolded RNA-binding: functions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations (PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:34739333, PubMed:36279435, PubMed:36692217). Also acts as an ATP- and magnesium-dependent helicase: unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency (PubMed:9889278). Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA (PubMed:9889278). Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends (PubMed:9889278). Plays an essential role in innate immunity by promoting CGAS and RIGI activity (PubMed:30510222, PubMed:30804210). Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS (PubMed:30510222). Triggers the condensation of cGAS, a process probably linked to the formation of membrane-less organelles (PubMed:34779554). Also enhances RIGI-induced type I interferon production probably by helping RIGI at sensing pathogenic RNA (PubMed:30804210). May also act as a phosphorylation-dependent sequence-specific endoribonuclease in vitro: Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR (PubMed:11604510). {ECO:0000269|PubMed:11604510, ECO:0000269|PubMed:12642610, ECO:0000269|PubMed:20180778, ECO:0000269|PubMed:23279204, ECO:0000269|PubMed:27022092, ECO:0000269|PubMed:30510222, ECO:0000269|PubMed:30804210, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:32302571, ECO:0000269|PubMed:32302572, ECO:0000269|PubMed:34739333, ECO:0000269|PubMed:34779554, ECO:0000269|PubMed:35977029, ECO:0000269|PubMed:36183834, ECO:0000269|PubMed:36279435, ECO:0000269|PubMed:36692217, ECO:0000269|PubMed:37379838, ECO:0000269|PubMed:9889278}. |
| Q9P2J5 | LARS1 | S391 | Sugiyama | Leucine--tRNA ligase, cytoplasmic (EC 6.1.1.4) (Leucyl-tRNA synthetase) (LeuRS) (cLRS) | Aminoacyl-tRNA synthetase that catalyzes the specific attachment of leucine to its cognate tRNA (tRNA(Leu)) (PubMed:25051973, PubMed:32232361). It performs tRNA aminoacylation in a two-step reaction: Leu is initially activated by ATP to form a leucyl-adenylate (Leu-AMP) intermediate; then the leucyl moiety is transferred to the acceptor 3' end of the tRNA to yield leucyl-tRNA (PubMed:25051973). To improve the fidelity of catalytic reactions, it is also able to hydrolyze misactivated aminoacyl-adenylate intermediates (pre-transfer editing) and mischarged aminoacyl-tRNAs (post-transfer editing) (PubMed:25051973). {ECO:0000269|PubMed:19426743, ECO:0000269|PubMed:25051973, ECO:0000269|PubMed:32232361}. |
| Q99613 | EIF3C | S154 | Sugiyama | Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 subunit 8) (eIF3 p110) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03002, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
| P46940 | IQGAP1 | S666 | Sugiyama | Ras GTPase-activating-like protein IQGAP1 (p195) | Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Recruited to the cell cortex by interaction with ILK which allows it to cooperate with its effector DIAPH1 to locally stabilize microtubules and allow stable insertion of caveolae into the plasma membrane (By similarity). Binds to activated CDC42 but does not stimulate its GTPase activity. Associates with calmodulin. May promote neurite outgrowth (PubMed:15695813). May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest (PubMed:20883816). {ECO:0000250|UniProtKB:Q9JKF1, ECO:0000269|PubMed:15695813, ECO:0000269|PubMed:20883816}. |
| Q9NYU2 | UGGT1 | S445 | Sugiyama | UDP-glucose:glycoprotein glucosyltransferase 1 (UGT1) (hUGT1) (EC 2.4.1.-) (UDP--Glc:glycoprotein glucosyltransferase) (UDP-glucose ceramide glucosyltransferase-like 1) | Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation. {ECO:0000269|PubMed:10694380}. |
| P32119 | PRDX2 | S151 | Sugiyama | Peroxiredoxin-2 (EC 1.11.1.24) (Natural killer cell-enhancing factor B) (NKEF-B) (PRP) (Thiol-specific antioxidant protein) (TSA) (Thioredoxin peroxidase 1) (Thioredoxin-dependent peroxide reductase 1) (Thioredoxin-dependent peroxiredoxin 2) | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). {ECO:0000269|PubMed:9497357}. |
| Q99614 | TTC1 | S155 | Sugiyama | Tetratricopeptide repeat protein 1 (TPR repeat protein 1) | None |
| Q13136 | PPFIA1 | S338 | Sugiyama | Liprin-alpha-1 (LAR-interacting protein 1) (LIP-1) (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) | May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269|PubMed:7796809}. |
| Q13765 | NACA | S191 | Sugiyama | Nascent polypeptide-associated complex subunit alpha (NAC-alpha) (Alpha-NAC) (allergen Hom s 2) | Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters. {ECO:0000269|PubMed:10982809, ECO:0000269|PubMed:15784678, ECO:0000269|PubMed:9877153}. |
| P53778 | MAPK12 | S43 | Sugiyama | Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3) | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation. Phosphorylates DLG1. Following osmotic shock, MAPK12 in the cell nucleus increases its association with nuclear DLG1, thereby causing dissociation of DLG1-SFPQ complexes. This function is independent of its catalytic activity and could affect mRNA processing and/or gene transcription to aid cell adaptation to osmolarity changes in the environment. Regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage and G2 arrest after gamma-radiation exposure. MAPK12 is involved in the regulation of SLC2A1 expression and basal glucose uptake in L6 myotubes; and negatively regulates SLC2A4 expression and contraction-mediated glucose uptake in adult skeletal muscle. C-Jun (JUN) phosphorylation is stimulated by MAPK14 and inhibited by MAPK12, leading to a distinct AP-1 regulation. MAPK12 is required for the normal kinetochore localization of PLK1, prevents chromosomal instability and supports mitotic cell viability. MAPK12-signaling is also positively regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration. {ECO:0000269|PubMed:10848581, ECO:0000269|PubMed:14592936, ECO:0000269|PubMed:17724032, ECO:0000269|PubMed:20605917, ECO:0000269|PubMed:21172807, ECO:0000269|PubMed:8633070, ECO:0000269|PubMed:9430721}. |
| Q8TB72 | PUM2 | S943 | Sugiyama | Pumilio homolog 2 (Pumilio-2) | Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (, PubMed:21397187). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:22345517). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517). Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm (PubMed:26724866). May regulate DCUN1D3 mRNA levels (PubMed:25349211). May support proliferation and self-renewal of stem cells. Binds specifically to miRNA MIR199A precursor, with PUM1, regulates miRNA MIR199A expression at a postranscriptional level (PubMed:28431233). {ECO:0000269|PubMed:18776931, ECO:0000269|PubMed:21397187, ECO:0000269|PubMed:22345517, ECO:0000269|PubMed:22955276, ECO:0000269|PubMed:25340845, ECO:0000269|PubMed:25349211, ECO:0000269|PubMed:26724866, ECO:0000269|PubMed:28431233}. |
| P04150 | NR3C1 | S746 | PSP | Glucocorticoid receptor (GR) (Nuclear receptor subfamily 3 group C member 1) | Receptor for glucocorticoids (GC) (PubMed:27120390, PubMed:37478846). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors (PubMed:28139699). Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:25775514, ECO:0000269|PubMed:27120390, ECO:0000269|PubMed:28139699, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:9590696}.; FUNCTION: [Isoform Alpha]: Has transcriptional activation and repression activity (PubMed:11435610, PubMed:15769988, PubMed:15866175, PubMed:17635946, PubMed:19141540, PubMed:19248771, PubMed:20484466, PubMed:21664385, PubMed:23820903). Mediates glucocorticoid-induced apoptosis (PubMed:23303127). Promotes accurate chromosome segregation during mitosis (PubMed:25847991). May act as a tumor suppressor (PubMed:25847991). May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression (By similarity). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:11435610, ECO:0000269|PubMed:15769988, ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:17635946, ECO:0000269|PubMed:19141540, ECO:0000269|PubMed:19248771, ECO:0000269|PubMed:20484466, ECO:0000269|PubMed:21664385, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903, ECO:0000269|PubMed:25847991}.; FUNCTION: [Isoform Beta]: Acts as a dominant negative inhibitor of isoform Alpha (PubMed:20484466, PubMed:7769088, PubMed:8621628). Has intrinsic transcriptional activity independent of isoform Alpha when both isoforms are coexpressed (PubMed:19248771, PubMed:26711253). Loses this transcription modulator function on its own (PubMed:20484466). Has no hormone-binding activity (PubMed:8621628). May play a role in controlling glucose metabolism by maintaining insulin sensitivity (By similarity). Reduces hepatic gluconeogenesis through down-regulation of PEPCK in an isoform Alpha-dependent manner (PubMed:26711253). Directly regulates STAT1 expression in isoform Alpha-independent manner (PubMed:26711253). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:19248771, ECO:0000269|PubMed:20484466, ECO:0000269|PubMed:26711253, ECO:0000269|PubMed:7769088, ECO:0000269|PubMed:8621628}.; FUNCTION: [Isoform Alpha-2]: Has lower transcriptional activation activity than isoform Alpha. Exerts a dominant negative effect on isoform Alpha trans-repression mechanism (PubMed:20484466).; FUNCTION: [Isoform GR-P]: Increases activity of isoform Alpha. {ECO:0000269|PubMed:11358809}.; FUNCTION: [Isoform Alpha-B]: More effective than isoform Alpha in transcriptional activation, but not repression activity. {ECO:0000269|PubMed:11435610, ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform 10]: Has transcriptional activation activity. {ECO:0000269|PubMed:20484466}.; FUNCTION: [Isoform Alpha-C1]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-C2]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-C3]: Has highest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127). Mediates glucocorticoid-induced apoptosis (PubMed:23303127, PubMed:23820903). {ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903}.; FUNCTION: [Isoform Alpha-D1]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-D2]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-D3]: Has lowest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127). {ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903}. |
| Q8N0Z6 | TTC5 | S203 | SIGNOR | Tetratricopeptide repeat protein 5 (TPR repeat protein 5) (Stress-responsive activator of p300) (Protein Strap) | Cofactor involved in the regulation of various cellular mechanisms such as actin regulation, autophagy, chromatin regulation and DNA repair (PubMed:18451878, PubMed:31727855). In non-stress conditions, interacts with cofactor JMY in the cytoplasm which prevents JMY's actin nucleation activity and ability to activate the Arp2/3 complex. Acts as a negative regulator of nutrient stress-induced autophagy by preventing JMY's interaction with MAP1LC3B, thereby preventing autophagosome formation (By similarity). Involves in tubulin autoregulation by promoting its degradation in response to excess soluble tubulin (PubMed:31727855). To do so, associates with the active ribosome near the ribosome exit tunnel and with nascent tubulin polypeptides early during their translation, triggering tubulin mRNA-targeted degradation (PubMed:31727855). Following DNA damage, phosphorylated by DNA damage responsive protein kinases ATM and CHEK2, leading to its nuclear accumulation and stability. Nuclear TTC5/STRAP promotes the assembly of a stress-responsive p53/TP53 coactivator complex, which includes the coactivators JMY and p300, thereby increasing p53/TP53-dependent transcription and apoptosis. Also recruits arginine methyltransferase PRMT5 to p53/TP53 when DNA is damaged, allowing PRMT5 to methylate p53/TP53. In DNA stress conditions, also prevents p53/TP53 degradation by E3 ubiquitin ligase MDM2 (By similarity). Upon heat-shock stress, forms a chromatin-associated complex with heat-shock factor 1 HSF1 and p300/EP300 to stimulate heat-shock-responsive transcription, thereby increasing cell survival (PubMed:18451878). Mitochondrial TTC5/STRAP interacts with ATP synthase subunit beta ATP5F1B which decreased ATP synthase activity and lowers mitochondrial ATP production, thereby regulating cellular respiration and mitochondrial-dependent apoptosis. Mitochondrial TTC5/STRAP also regulates p53/TP53-mediated apoptosis (By similarity). {ECO:0000250|UniProtKB:Q99LG4, ECO:0000269|PubMed:18451878, ECO:0000269|PubMed:31727855}. |
| Q15418 | RPS6KA1 | S402 | Sugiyama | Ribosomal protein S6 kinase alpha-1 (S6K-alpha-1) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (p90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPK-activated protein kinase 1a) (MAPKAP kinase 1a) (MAPKAPK-1a) (Ribosomal S6 kinase 1) (RSK-1) | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1 (PubMed:10679322, PubMed:12213813, PubMed:15117958, PubMed:16223362, PubMed:17360704, PubMed:18722121, PubMed:26158630, PubMed:35772404, PubMed:9430688). In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes (PubMed:18508509, PubMed:18813292). In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP (PubMed:12213813, PubMed:16223362). Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity (PubMed:18508509, PubMed:18813292). Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the pre-initiation complex (PubMed:17360704). In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation (PubMed:16763566). Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway (PubMed:15342917). Also involved in feedback regulation of mTORC1 and mTORC2 by phosphorylating DEPTOR (PubMed:22017876). Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function (PubMed:10679322, PubMed:16213824). Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4) (PubMed:11684016). Mediates induction of hepatocyte prolifration by TGFA through phosphorylation of CEBPB (PubMed:18508509, PubMed:18813292). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression (PubMed:18508509, PubMed:18813292). Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630). In response to mTORC1 activation, phosphorylates EIF4B at 'Ser-406' and 'Ser-422' which stimulates bicarbonate cotransporter SLC4A7 mRNA translation, increasing SLC4A7 protein abundance and function (PubMed:35772404). {ECO:0000269|PubMed:10679322, ECO:0000269|PubMed:11684016, ECO:0000269|PubMed:12213813, ECO:0000269|PubMed:15117958, ECO:0000269|PubMed:15342917, ECO:0000269|PubMed:16213824, ECO:0000269|PubMed:16223362, ECO:0000269|PubMed:16763566, ECO:0000269|PubMed:17360704, ECO:0000269|PubMed:18722121, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:35772404, ECO:0000269|PubMed:9430688, ECO:0000303|PubMed:18508509, ECO:0000303|PubMed:18813292}.; FUNCTION: (Microbial infection) Promotes the late transcription and translation of viral lytic genes during Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, when constitutively activated. {ECO:0000269|PubMed:30842327}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-383280 | Nuclear Receptor transcription pathway | 1.114986e-07 | 6.953 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 2.417199e-05 | 4.617 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 3.696779e-05 | 4.432 |
| R-HSA-8863678 | Neurodegenerative Diseases | 1.726122e-04 | 3.763 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 1.726122e-04 | 3.763 |
| R-HSA-212436 | Generic Transcription Pathway | 1.522341e-04 | 3.817 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 2.475067e-04 | 3.606 |
| R-HSA-73857 | RNA Polymerase II Transcription | 2.860852e-04 | 3.544 |
| R-HSA-74160 | Gene expression (Transcription) | 3.550804e-04 | 3.450 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 7.212530e-04 | 3.142 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 1.327109e-03 | 2.877 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 1.892906e-03 | 2.723 |
| R-HSA-69481 | G2/M Checkpoints | 1.927592e-03 | 2.715 |
| R-HSA-6807070 | PTEN Regulation | 3.060915e-03 | 2.514 |
| R-HSA-8948747 | Regulation of PTEN localization | 3.795468e-03 | 2.421 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 3.503120e-03 | 2.456 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 3.795468e-03 | 2.421 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 5.401633e-03 | 2.267 |
| R-HSA-877300 | Interferon gamma signaling | 5.608438e-03 | 2.251 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 5.917002e-03 | 2.228 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 6.728437e-03 | 2.172 |
| R-HSA-418359 | Reduction of cytosolic Ca++ levels | 8.292867e-03 | 2.081 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 8.292867e-03 | 2.081 |
| R-HSA-3304347 | Loss of Function of SMAD4 in Cancer | 2.665445e-02 | 1.574 |
| R-HSA-3311021 | SMAD4 MH2 Domain Mutants in Cancer | 2.665445e-02 | 1.574 |
| R-HSA-5674404 | PTEN Loss of Function in Cancer | 2.665445e-02 | 1.574 |
| R-HSA-3315487 | SMAD2/3 MH2 Domain Mutants in Cancer | 2.665445e-02 | 1.574 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 3.538151e-02 | 1.451 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 3.538151e-02 | 1.451 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 3.538151e-02 | 1.451 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 3.538151e-02 | 1.451 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 3.538151e-02 | 1.451 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 3.538151e-02 | 1.451 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 3.538151e-02 | 1.451 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 3.538151e-02 | 1.451 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 3.538151e-02 | 1.451 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 3.538151e-02 | 1.451 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 3.538151e-02 | 1.451 |
| R-HSA-8952158 | RUNX3 regulates BCL2L11 (BIM) transcription | 5.260320e-02 | 1.279 |
| R-HSA-3656532 | TGFBR1 KD Mutants in Cancer | 5.260320e-02 | 1.279 |
| R-HSA-3304356 | SMAD2/3 Phosphorylation Motif Mutants in Cancer | 6.109919e-02 | 1.214 |
| R-HSA-3304349 | Loss of Function of SMAD2/3 in Cancer | 6.951951e-02 | 1.158 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 6.951951e-02 | 1.158 |
| R-HSA-629587 | Highly sodium permeable postsynaptic acetylcholine nicotinic receptors | 7.786482e-02 | 1.109 |
| R-HSA-9912481 | Branched-chain ketoacid dehydrogenase kinase deficiency | 7.786482e-02 | 1.109 |
| R-HSA-444257 | RSK activation | 9.433311e-02 | 1.025 |
| R-HSA-629597 | Highly calcium permeable nicotinic acetylcholine receptors | 9.433311e-02 | 1.025 |
| R-HSA-629594 | Highly calcium permeable postsynaptic nicotinic acetylcholine receptors | 1.105093e-01 | 0.957 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 1.263985e-01 | 0.898 |
| R-HSA-5358493 | Synthesis of diphthamide-EEF2 | 1.263985e-01 | 0.898 |
| R-HSA-622323 | Presynaptic nicotinic acetylcholine receptors | 1.263985e-01 | 0.898 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 1.342371e-01 | 0.872 |
| R-HSA-181431 | Acetylcholine binding and downstream events | 1.420058e-01 | 0.848 |
| R-HSA-622327 | Postsynaptic nicotinic acetylcholine receptors | 1.420058e-01 | 0.848 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 1.420058e-01 | 0.848 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 1.497053e-01 | 0.825 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 1.573361e-01 | 0.803 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 1.573361e-01 | 0.803 |
| R-HSA-5656121 | Translesion synthesis by POLI | 1.648990e-01 | 0.783 |
| R-HSA-5655862 | Translesion synthesis by POLK | 1.723944e-01 | 0.763 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 1.798231e-01 | 0.745 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 1.798231e-01 | 0.745 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 1.871855e-01 | 0.728 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 1.871855e-01 | 0.728 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 2.685345e-02 | 1.571 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 2.685345e-02 | 1.571 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 1.944822e-01 | 0.711 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 2.881524e-02 | 1.540 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 2.982394e-02 | 1.525 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 2.017139e-01 | 0.695 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 2.017139e-01 | 0.695 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.017139e-01 | 0.695 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 2.017139e-01 | 0.695 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.017139e-01 | 0.695 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 2.088812e-01 | 0.680 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 2.088812e-01 | 0.680 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 3.740024e-02 | 1.427 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 2.159845e-01 | 0.666 |
| R-HSA-380287 | Centrosome maturation | 3.972904e-02 | 1.401 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 2.437699e-01 | 0.613 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 1.138832e-01 | 0.944 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 5.801189e-02 | 1.236 |
| R-HSA-6782135 | Dual incision in TC-NER | 1.197534e-01 | 0.922 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 2.705771e-01 | 0.568 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 2.771302e-01 | 0.557 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 2.836247e-01 | 0.547 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 2.836247e-01 | 0.547 |
| R-HSA-156902 | Peptide chain elongation | 2.176737e-01 | 0.662 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 2.474446e-01 | 0.607 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 2.505620e-01 | 0.601 |
| R-HSA-9823730 | Formation of definitive endoderm | 2.017139e-01 | 0.695 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 1.501227e-01 | 0.824 |
| R-HSA-68962 | Activation of the pre-replicative complex | 4.227731e-02 | 1.374 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 6.089814e-02 | 1.215 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 2.705771e-01 | 0.568 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 2.369166e-01 | 0.625 |
| R-HSA-110312 | Translesion synthesis by REV1 | 1.573361e-01 | 0.803 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 5.100543e-02 | 1.292 |
| R-HSA-69091 | Polymerase switching | 1.342371e-01 | 0.872 |
| R-HSA-69109 | Leading Strand Synthesis | 1.342371e-01 | 0.872 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 4.876681e-02 | 1.312 |
| R-HSA-110320 | Translesion Synthesis by POLH | 1.944822e-01 | 0.711 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 2.437699e-01 | 0.613 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 2.437699e-01 | 0.613 |
| R-HSA-399719 | Trafficking of AMPA receptors | 2.836247e-01 | 0.547 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 2.900613e-01 | 0.538 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 1.052261e-01 | 0.978 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 1.721970e-01 | 0.764 |
| R-HSA-1606341 | IRF3 mediated activation of type 1 IFN | 6.109919e-02 | 1.214 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 7.786482e-02 | 1.109 |
| R-HSA-163754 | Insulin effects increased synthesis of Xylulose-5-Phosphate | 8.613581e-02 | 1.065 |
| R-HSA-8849473 | PTK6 Expression | 8.613581e-02 | 1.065 |
| R-HSA-444473 | Formyl peptide receptors bind formyl peptides and many other ligands | 9.433311e-02 | 1.025 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 6.031510e-02 | 1.220 |
| R-HSA-5674135 | MAP2K and MAPK activation | 7.269186e-02 | 1.139 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 8.312622e-02 | 1.080 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 1.723944e-01 | 0.763 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 1.871855e-01 | 0.728 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 3.085113e-02 | 1.511 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 2.779826e-02 | 1.556 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 2.505620e-01 | 0.601 |
| R-HSA-426486 | Small interfering RNA (siRNA) biogenesis | 7.786482e-02 | 1.109 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 1.184894e-01 | 0.926 |
| R-HSA-6798695 | Neutrophil degranulation | 6.835922e-02 | 1.165 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 1.915131e-01 | 0.718 |
| R-HSA-3304351 | Signaling by TGF-beta Receptor Complex in Cancer | 7.786482e-02 | 1.109 |
| R-HSA-3371511 | HSF1 activation | 5.793602e-02 | 1.237 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 7.269186e-02 | 1.139 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 8.580286e-02 | 1.066 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 8.580286e-02 | 1.066 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 8.580286e-02 | 1.066 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 2.341833e-01 | 0.630 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 1.944822e-01 | 0.711 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 5.244128e-02 | 1.280 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 2.856807e-02 | 1.544 |
| R-HSA-5693538 | Homology Directed Repair | 3.215323e-02 | 1.493 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 6.641437e-02 | 1.178 |
| R-HSA-9636667 | Manipulation of host energy metabolism | 2.665445e-02 | 1.574 |
| R-HSA-3656534 | Loss of Function of TGFBR1 in Cancer | 6.109919e-02 | 1.214 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 6.951951e-02 | 1.158 |
| R-HSA-176974 | Unwinding of DNA | 1.024574e-01 | 0.989 |
| R-HSA-2151209 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation | 1.105093e-01 | 0.957 |
| R-HSA-192905 | vRNP Assembly | 1.184894e-01 | 0.926 |
| R-HSA-525793 | Myogenesis | 3.418521e-02 | 1.466 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 1.342371e-01 | 0.872 |
| R-HSA-9796292 | Formation of axial mesoderm | 1.420058e-01 | 0.848 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 1.871855e-01 | 0.728 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 1.871855e-01 | 0.728 |
| R-HSA-350054 | Notch-HLH transcription pathway | 2.230244e-01 | 0.652 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 2.437699e-01 | 0.613 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 1.532404e-01 | 0.815 |
| R-HSA-6802949 | Signaling by RAS mutants | 8.580286e-02 | 1.066 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 2.771302e-01 | 0.557 |
| R-HSA-5696398 | Nucleotide Excision Repair | 2.839950e-01 | 0.547 |
| R-HSA-1181150 | Signaling by NODAL | 2.172966e-02 | 1.663 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 2.771302e-01 | 0.557 |
| R-HSA-1502540 | Signaling by Activin | 1.299774e-02 | 1.886 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 1.299774e-02 | 1.886 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 2.230244e-01 | 0.652 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 1.099783e-01 | 0.959 |
| R-HSA-165159 | MTOR signalling | 7.525822e-02 | 1.123 |
| R-HSA-166208 | mTORC1-mediated signalling | 2.678676e-02 | 1.572 |
| R-HSA-3371571 | HSF1-dependent transactivation | 9.956047e-02 | 1.002 |
| R-HSA-203927 | MicroRNA (miRNA) biogenesis | 2.437699e-01 | 0.613 |
| R-HSA-9006936 | Signaling by TGFB family members | 2.167914e-01 | 0.664 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 1.871855e-01 | 0.728 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 6.971433e-02 | 1.157 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 2.051766e-01 | 0.688 |
| R-HSA-205025 | NADE modulates death signalling | 5.260320e-02 | 1.279 |
| R-HSA-193670 | p75NTR negatively regulates cell cycle via SC1 | 5.260320e-02 | 1.279 |
| R-HSA-69190 | DNA strand elongation | 4.656535e-02 | 1.332 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 1.573361e-01 | 0.803 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 2.088812e-01 | 0.680 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 2.369166e-01 | 0.625 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 5.109130e-02 | 1.292 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 2.505620e-01 | 0.601 |
| R-HSA-445355 | Smooth Muscle Contraction | 1.052261e-01 | 0.978 |
| R-HSA-3371556 | Cellular response to heat stress | 3.447256e-02 | 1.463 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 2.369166e-01 | 0.625 |
| R-HSA-69306 | DNA Replication | 2.005725e-01 | 0.698 |
| R-HSA-73894 | DNA Repair | 1.297961e-01 | 0.887 |
| R-HSA-5578775 | Ion homeostasis | 1.138832e-01 | 0.944 |
| R-HSA-392517 | Rap1 signalling | 1.944822e-01 | 0.711 |
| R-HSA-6784531 | tRNA processing in the nucleus | 1.317105e-01 | 0.880 |
| R-HSA-9008059 | Interleukin-37 signaling | 2.771302e-01 | 0.557 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 2.771302e-01 | 0.557 |
| R-HSA-69186 | Lagging Strand Synthesis | 2.088812e-01 | 0.680 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 2.159845e-01 | 0.666 |
| R-HSA-5689603 | UCH proteinases | 1.753939e-01 | 0.756 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 1.263985e-01 | 0.898 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 1.723944e-01 | 0.763 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 1.871855e-01 | 0.728 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 2.441261e-01 | 0.612 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 1.944822e-01 | 0.711 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 1.626678e-01 | 0.789 |
| R-HSA-199920 | CREB phosphorylation | 7.786482e-02 | 1.109 |
| R-HSA-426117 | Cation-coupled Chloride cotransporters | 8.613581e-02 | 1.065 |
| R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 1.105093e-01 | 0.957 |
| R-HSA-9839394 | TGFBR3 expression | 3.226825e-02 | 1.491 |
| R-HSA-418360 | Platelet calcium homeostasis | 4.019246e-02 | 1.396 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 2.230244e-01 | 0.652 |
| R-HSA-3238698 | WNT ligand biogenesis and trafficking | 2.230244e-01 | 0.652 |
| R-HSA-429947 | Deadenylation of mRNA | 2.369166e-01 | 0.625 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 2.505620e-01 | 0.601 |
| R-HSA-68877 | Mitotic Prometaphase | 1.255851e-01 | 0.901 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 2.705771e-01 | 0.568 |
| R-HSA-2243919 | Crosslinking of collagen fibrils | 1.944822e-01 | 0.711 |
| R-HSA-9768777 | Regulation of NPAS4 gene transcription | 1.024574e-01 | 0.989 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 4.876681e-02 | 1.312 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 1.723944e-01 | 0.763 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 1.944822e-01 | 0.711 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 8.312622e-02 | 1.080 |
| R-HSA-69275 | G2/M Transition | 3.876854e-02 | 1.412 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 2.378259e-02 | 1.624 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 4.013470e-02 | 1.396 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 6.109919e-02 | 1.214 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 1.052775e-02 | 1.978 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 1.299774e-02 | 1.886 |
| R-HSA-9834752 | Respiratory syncytial virus genome replication | 1.024574e-01 | 0.989 |
| R-HSA-9013700 | NOTCH4 Activation and Transmission of Signal to the Nucleus | 1.024574e-01 | 0.989 |
| R-HSA-9005895 | Pervasive developmental disorders | 1.342371e-01 | 0.872 |
| R-HSA-9697154 | Disorders of Nervous System Development | 1.342371e-01 | 0.872 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 1.342371e-01 | 0.872 |
| R-HSA-171007 | p38MAPK events | 1.573361e-01 | 0.803 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 1.648990e-01 | 0.783 |
| R-HSA-211000 | Gene Silencing by RNA | 9.324031e-02 | 1.030 |
| R-HSA-397014 | Muscle contraction | 1.580411e-01 | 0.801 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 1.721970e-01 | 0.764 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 1.798231e-01 | 0.745 |
| R-HSA-114608 | Platelet degranulation | 4.025449e-02 | 1.395 |
| R-HSA-5617833 | Cilium Assembly | 1.209858e-01 | 0.917 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 4.335713e-02 | 1.363 |
| R-HSA-936837 | Ion transport by P-type ATPases | 1.377885e-01 | 0.861 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 4.876681e-02 | 1.312 |
| R-HSA-199991 | Membrane Trafficking | 2.564220e-01 | 0.591 |
| R-HSA-442380 | Zinc influx into cells by the SLC39 gene family | 1.024574e-01 | 0.989 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 1.648990e-01 | 0.783 |
| R-HSA-9675151 | Disorders of Developmental Biology | 1.723944e-01 | 0.763 |
| R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | 2.505620e-01 | 0.601 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 2.836247e-01 | 0.547 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 2.836247e-01 | 0.547 |
| R-HSA-9013694 | Signaling by NOTCH4 | 1.690101e-01 | 0.772 |
| R-HSA-69242 | S Phase | 1.891765e-01 | 0.723 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 5.100543e-02 | 1.292 |
| R-HSA-198753 | ERK/MAPK targets | 2.088812e-01 | 0.680 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 2.771302e-01 | 0.557 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 4.655604e-02 | 1.332 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 2.707044e-01 | 0.568 |
| R-HSA-9614085 | FOXO-mediated transcription | 7.792996e-02 | 1.108 |
| R-HSA-168255 | Influenza Infection | 2.644398e-01 | 0.578 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 1.658335e-01 | 0.780 |
| R-HSA-70171 | Glycolysis | 1.853491e-02 | 1.732 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 8.807274e-02 | 1.055 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 5.750475e-02 | 1.240 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 1.944822e-01 | 0.711 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 2.572936e-01 | 0.590 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 2.705771e-01 | 0.568 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 2.771302e-01 | 0.557 |
| R-HSA-69278 | Cell Cycle, Mitotic | 4.034161e-02 | 1.394 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 1.347416e-01 | 0.870 |
| R-HSA-8848021 | Signaling by PTK6 | 1.347416e-01 | 0.870 |
| R-HSA-8876725 | Protein methylation | 1.573361e-01 | 0.803 |
| R-HSA-6787450 | tRNA modification in the mitochondrion | 1.723944e-01 | 0.763 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 2.088812e-01 | 0.680 |
| R-HSA-901032 | ER Quality Control Compartment (ERQC) | 2.572936e-01 | 0.590 |
| R-HSA-1640170 | Cell Cycle | 1.491735e-02 | 1.826 |
| R-HSA-9645723 | Diseases of programmed cell death | 1.189023e-02 | 1.925 |
| R-HSA-2262752 | Cellular responses to stress | 1.443838e-01 | 0.840 |
| R-HSA-114452 | Activation of BH3-only proteins | 4.227731e-02 | 1.374 |
| R-HSA-422356 | Regulation of insulin secretion | 2.574090e-01 | 0.589 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 2.546044e-02 | 1.594 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 2.257310e-02 | 1.646 |
| R-HSA-5633007 | Regulation of TP53 Activity | 2.167914e-01 | 0.664 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 9.433311e-02 | 1.025 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 2.505260e-02 | 1.601 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 1.573361e-01 | 0.803 |
| R-HSA-167044 | Signalling to RAS | 2.088812e-01 | 0.680 |
| R-HSA-70326 | Glucose metabolism | 3.140119e-02 | 1.503 |
| R-HSA-69620 | Cell Cycle Checkpoints | 4.078629e-02 | 1.389 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.666384e-01 | 0.778 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 1.573361e-01 | 0.803 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 2.505620e-01 | 0.601 |
| R-HSA-9865118 | Diseases of branched-chain amino acid catabolism | 2.505620e-01 | 0.601 |
| R-HSA-5688426 | Deubiquitination | 3.903993e-02 | 1.408 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 7.269186e-02 | 1.139 |
| R-HSA-9839373 | Signaling by TGFBR3 | 8.580286e-02 | 1.066 |
| R-HSA-162582 | Signal Transduction | 1.939216e-01 | 0.712 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 7.088572e-02 | 1.149 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 2.505260e-02 | 1.601 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 2.639651e-01 | 0.578 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 1.626678e-01 | 0.789 |
| R-HSA-163685 | Integration of energy metabolism | 1.604228e-01 | 0.795 |
| R-HSA-909733 | Interferon alpha/beta signaling | 2.992862e-02 | 1.524 |
| R-HSA-913531 | Interferon Signaling | 1.132719e-02 | 1.946 |
| R-HSA-435354 | Zinc transporters | 1.497053e-01 | 0.825 |
| R-HSA-373753 | Nephrin family interactions | 2.017139e-01 | 0.695 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 2.839950e-01 | 0.547 |
| R-HSA-5689880 | Ub-specific processing proteases | 9.638588e-02 | 1.016 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 2.230244e-01 | 0.652 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 3.447256e-02 | 1.463 |
| R-HSA-1266738 | Developmental Biology | 2.355005e-01 | 0.628 |
| R-HSA-72306 | tRNA processing | 2.427973e-01 | 0.615 |
| R-HSA-8983711 | OAS antiviral response | 1.342371e-01 | 0.872 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 2.437699e-01 | 0.613 |
| R-HSA-418346 | Platelet homeostasis | 2.873149e-01 | 0.542 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 6.626114e-02 | 1.179 |
| R-HSA-70263 | Gluconeogenesis | 1.451232e-02 | 1.838 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 1.275380e-01 | 0.894 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 6.740201e-02 | 1.171 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 1.393222e-01 | 0.856 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 2.806737e-01 | 0.552 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 2.806737e-01 | 0.552 |
| R-HSA-9711123 | Cellular response to chemical stress | 4.696215e-02 | 1.328 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 1.240438e-01 | 0.906 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 2.607324e-01 | 0.584 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 6.236613e-02 | 1.205 |
| R-HSA-1483255 | PI Metabolism | 2.707044e-01 | 0.568 |
| R-HSA-2028269 | Signaling by Hippo | 1.798231e-01 | 0.745 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 1.174880e-01 | 0.930 |
| R-HSA-9679506 | SARS-CoV Infections | 1.498434e-01 | 0.824 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 1.138832e-01 | 0.944 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 9.914591e-02 | 1.004 |
| R-HSA-166520 | Signaling by NTRKs | 1.891765e-01 | 0.723 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 1.023823e-01 | 0.990 |
| R-HSA-157118 | Signaling by NOTCH | 2.079630e-01 | 0.682 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 1.138832e-01 | 0.944 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 2.900613e-01 | 0.538 |
| R-HSA-5357801 | Programmed Cell Death | 1.463421e-01 | 0.835 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 3.833842e-02 | 1.416 |
| R-HSA-109581 | Apoptosis | 2.214762e-01 | 0.655 |
| R-HSA-69239 | Synthesis of DNA | 2.906333e-01 | 0.537 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 2.939499e-01 | 0.532 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 2.939499e-01 | 0.532 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 2.964404e-01 | 0.528 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 2.964404e-01 | 0.528 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 2.964404e-01 | 0.528 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 2.964404e-01 | 0.528 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 2.964404e-01 | 0.528 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 2.964404e-01 | 0.528 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 2.964404e-01 | 0.528 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 2.964404e-01 | 0.528 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 2.964404e-01 | 0.528 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 2.972645e-01 | 0.527 |
| R-HSA-68886 | M Phase | 2.981632e-01 | 0.526 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 3.005768e-01 | 0.522 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 3.005768e-01 | 0.522 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 3.027627e-01 | 0.519 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 3.027627e-01 | 0.519 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 3.027627e-01 | 0.519 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 3.027627e-01 | 0.519 |
| R-HSA-1483249 | Inositol phosphate metabolism | 3.071937e-01 | 0.513 |
| R-HSA-5696400 | Dual Incision in GG-NER | 3.090285e-01 | 0.510 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 3.090285e-01 | 0.510 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 3.090285e-01 | 0.510 |
| R-HSA-203615 | eNOS activation | 3.090285e-01 | 0.510 |
| R-HSA-180746 | Nuclear import of Rev protein | 3.090285e-01 | 0.510 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 3.090285e-01 | 0.510 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 3.090285e-01 | 0.510 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 3.152384e-01 | 0.501 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 3.152384e-01 | 0.501 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 3.152384e-01 | 0.501 |
| R-HSA-187687 | Signalling to ERKs | 3.152384e-01 | 0.501 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 3.156870e-01 | 0.501 |
| R-HSA-9682385 | FLT3 signaling in disease | 3.213928e-01 | 0.493 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 3.213928e-01 | 0.493 |
| R-HSA-8941326 | RUNX2 regulates bone development | 3.213928e-01 | 0.493 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 3.236811e-01 | 0.490 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 3.269675e-01 | 0.485 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 3.269675e-01 | 0.485 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 3.274923e-01 | 0.485 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 3.274923e-01 | 0.485 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 3.274923e-01 | 0.485 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 3.274923e-01 | 0.485 |
| R-HSA-419037 | NCAM1 interactions | 3.274923e-01 | 0.485 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 3.274923e-01 | 0.485 |
| R-HSA-196757 | Metabolism of folate and pterines | 3.274923e-01 | 0.485 |
| R-HSA-1592230 | Mitochondrial biogenesis | 3.302499e-01 | 0.481 |
| R-HSA-5653656 | Vesicle-mediated transport | 3.312016e-01 | 0.480 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 3.335374e-01 | 0.477 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 3.335374e-01 | 0.477 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 3.335374e-01 | 0.477 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 3.335374e-01 | 0.477 |
| R-HSA-1566948 | Elastic fibre formation | 3.335374e-01 | 0.477 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 3.335374e-01 | 0.477 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 3.368013e-01 | 0.473 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 3.395285e-01 | 0.469 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 3.395285e-01 | 0.469 |
| R-HSA-71336 | Pentose phosphate pathway | 3.395285e-01 | 0.469 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 3.395285e-01 | 0.469 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 3.395285e-01 | 0.469 |
| R-HSA-201556 | Signaling by ALK | 3.395285e-01 | 0.469 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 3.395285e-01 | 0.469 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 3.454661e-01 | 0.462 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 3.454661e-01 | 0.462 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 3.454661e-01 | 0.462 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 3.454661e-01 | 0.462 |
| R-HSA-3371568 | Attenuation phase | 3.454661e-01 | 0.462 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 3.454661e-01 | 0.462 |
| R-HSA-9646399 | Aggrephagy | 3.454661e-01 | 0.462 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 3.475823e-01 | 0.459 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 3.513507e-01 | 0.454 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 3.513507e-01 | 0.454 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 3.513507e-01 | 0.454 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 3.513507e-01 | 0.454 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 3.513507e-01 | 0.454 |
| R-HSA-167161 | HIV Transcription Initiation | 3.571827e-01 | 0.447 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 3.571827e-01 | 0.447 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 3.571827e-01 | 0.447 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 3.571827e-01 | 0.447 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 3.571827e-01 | 0.447 |
| R-HSA-6811438 | Intra-Golgi traffic | 3.571827e-01 | 0.447 |
| R-HSA-1500931 | Cell-Cell communication | 3.585385e-01 | 0.445 |
| R-HSA-194138 | Signaling by VEGF | 3.595743e-01 | 0.444 |
| R-HSA-69206 | G1/S Transition | 3.595743e-01 | 0.444 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 3.629627e-01 | 0.440 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 3.629627e-01 | 0.440 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 3.629627e-01 | 0.440 |
| R-HSA-449147 | Signaling by Interleukins | 3.636899e-01 | 0.439 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 3.686911e-01 | 0.433 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 3.686911e-01 | 0.433 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 3.686911e-01 | 0.433 |
| R-HSA-112315 | Transmission across Chemical Synapses | 3.728057e-01 | 0.429 |
| R-HSA-3214858 | RMTs methylate histone arginines | 3.743683e-01 | 0.427 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 3.799948e-01 | 0.420 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 3.799948e-01 | 0.420 |
| R-HSA-5576891 | Cardiac conduction | 3.820604e-01 | 0.418 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 3.855710e-01 | 0.414 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 3.855710e-01 | 0.414 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 3.855710e-01 | 0.414 |
| R-HSA-9675135 | Diseases of DNA repair | 3.855710e-01 | 0.414 |
| R-HSA-75153 | Apoptotic execution phase | 3.855710e-01 | 0.414 |
| R-HSA-1483191 | Synthesis of PC | 3.910974e-01 | 0.408 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 3.910974e-01 | 0.408 |
| R-HSA-437239 | Recycling pathway of L1 | 3.910974e-01 | 0.408 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 3.965745e-01 | 0.402 |
| R-HSA-5620924 | Intraflagellar transport | 3.965745e-01 | 0.402 |
| R-HSA-9031628 | NGF-stimulated transcription | 3.965745e-01 | 0.402 |
| R-HSA-425410 | Metal ion SLC transporters | 3.965745e-01 | 0.402 |
| R-HSA-73893 | DNA Damage Bypass | 4.020026e-01 | 0.396 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 4.020026e-01 | 0.396 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 4.020026e-01 | 0.396 |
| R-HSA-380108 | Chemokine receptors bind chemokines | 4.020026e-01 | 0.396 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 4.042095e-01 | 0.393 |
| R-HSA-70895 | Branched-chain amino acid catabolism | 4.127139e-01 | 0.384 |
| R-HSA-1632852 | Macroautophagy | 4.166982e-01 | 0.380 |
| R-HSA-68949 | Orc1 removal from chromatin | 4.179978e-01 | 0.379 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 4.179978e-01 | 0.379 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 4.179978e-01 | 0.379 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 4.228938e-01 | 0.374 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 4.232345e-01 | 0.373 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 4.232345e-01 | 0.373 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 4.277082e-01 | 0.369 |
| R-HSA-72649 | Translation initiation complex formation | 4.284244e-01 | 0.368 |
| R-HSA-3214815 | HDACs deacetylate histones | 4.335680e-01 | 0.363 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 4.351833e-01 | 0.361 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 4.386656e-01 | 0.358 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 4.386656e-01 | 0.358 |
| R-HSA-177929 | Signaling by EGFR | 4.386656e-01 | 0.358 |
| R-HSA-109582 | Hemostasis | 4.392086e-01 | 0.357 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 4.412758e-01 | 0.355 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 4.437176e-01 | 0.353 |
| R-HSA-9764561 | Regulation of CDH1 Function | 4.437176e-01 | 0.353 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 4.437176e-01 | 0.353 |
| R-HSA-9679191 | Potential therapeutics for SARS | 4.473325e-01 | 0.349 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 4.487244e-01 | 0.348 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 4.487244e-01 | 0.348 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 4.533526e-01 | 0.344 |
| R-HSA-191859 | snRNP Assembly | 4.536865e-01 | 0.343 |
| R-HSA-194441 | Metabolism of non-coding RNA | 4.536865e-01 | 0.343 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 4.536865e-01 | 0.343 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 4.536865e-01 | 0.343 |
| R-HSA-180786 | Extension of Telomeres | 4.536865e-01 | 0.343 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 4.536865e-01 | 0.343 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 4.586042e-01 | 0.339 |
| R-HSA-379724 | tRNA Aminoacylation | 4.586042e-01 | 0.339 |
| R-HSA-1227986 | Signaling by ERBB2 | 4.586042e-01 | 0.339 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 4.586042e-01 | 0.339 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 4.586042e-01 | 0.339 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 4.586042e-01 | 0.339 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 4.586042e-01 | 0.339 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 4.586042e-01 | 0.339 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 4.586042e-01 | 0.339 |
| R-HSA-73887 | Death Receptor Signaling | 4.593357e-01 | 0.338 |
| R-HSA-168256 | Immune System | 4.599280e-01 | 0.337 |
| R-HSA-9824446 | Viral Infection Pathways | 4.605944e-01 | 0.337 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 4.634780e-01 | 0.334 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 4.634780e-01 | 0.334 |
| R-HSA-450294 | MAP kinase activation | 4.634780e-01 | 0.334 |
| R-HSA-9612973 | Autophagy | 4.652810e-01 | 0.332 |
| R-HSA-162587 | HIV Life Cycle | 4.682394e-01 | 0.330 |
| R-HSA-9707616 | Heme signaling | 4.683082e-01 | 0.329 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 4.683082e-01 | 0.329 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 4.683082e-01 | 0.329 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 4.683082e-01 | 0.329 |
| R-HSA-9711097 | Cellular response to starvation | 4.711881e-01 | 0.327 |
| R-HSA-373755 | Semaphorin interactions | 4.730952e-01 | 0.325 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 4.778394e-01 | 0.321 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 4.872009e-01 | 0.312 |
| R-HSA-2408522 | Selenoamino acid metabolism | 4.886743e-01 | 0.311 |
| R-HSA-5693606 | DNA Double Strand Break Response | 4.918190e-01 | 0.308 |
| R-HSA-167172 | Transcription of the HIV genome | 4.963958e-01 | 0.304 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 4.963958e-01 | 0.304 |
| R-HSA-5218859 | Regulated Necrosis | 4.963958e-01 | 0.304 |
| R-HSA-446728 | Cell junction organization | 5.038586e-01 | 0.298 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 5.054268e-01 | 0.296 |
| R-HSA-448424 | Interleukin-17 signaling | 5.054268e-01 | 0.296 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 5.054268e-01 | 0.296 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 5.060937e-01 | 0.296 |
| R-HSA-8953854 | Metabolism of RNA | 5.083638e-01 | 0.294 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 5.088903e-01 | 0.293 |
| R-HSA-8978934 | Metabolism of cofactors | 5.098818e-01 | 0.293 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 5.142970e-01 | 0.289 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 5.142970e-01 | 0.289 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 5.142970e-01 | 0.289 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 5.170085e-01 | 0.287 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 5.170085e-01 | 0.287 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 5.186727e-01 | 0.285 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 5.186727e-01 | 0.285 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 5.186727e-01 | 0.285 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 5.230092e-01 | 0.281 |
| R-HSA-8852135 | Protein ubiquitination | 5.273069e-01 | 0.278 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 5.273069e-01 | 0.278 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 5.281571e-01 | 0.277 |
| R-HSA-1980143 | Signaling by NOTCH1 | 5.315662e-01 | 0.274 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 5.357873e-01 | 0.271 |
| R-HSA-1483257 | Phospholipid metabolism | 5.411340e-01 | 0.267 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 5.432771e-01 | 0.265 |
| R-HSA-9659379 | Sensory processing of sound | 5.441166e-01 | 0.264 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 5.442927e-01 | 0.264 |
| R-HSA-195721 | Signaling by WNT | 5.475462e-01 | 0.262 |
| R-HSA-9833482 | PKR-mediated signaling | 5.482255e-01 | 0.261 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 5.482255e-01 | 0.261 |
| R-HSA-375276 | Peptide ligand-binding receptors | 5.522683e-01 | 0.258 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 5.522975e-01 | 0.258 |
| R-HSA-597592 | Post-translational protein modification | 5.537297e-01 | 0.257 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 5.563331e-01 | 0.255 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 5.563331e-01 | 0.255 |
| R-HSA-983712 | Ion channel transport | 5.601461e-01 | 0.252 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 5.603325e-01 | 0.252 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 5.642962e-01 | 0.248 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 5.642962e-01 | 0.248 |
| R-HSA-168898 | Toll-like Receptor Cascades | 5.653433e-01 | 0.248 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 5.682243e-01 | 0.245 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 5.721173e-01 | 0.243 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 5.730569e-01 | 0.242 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 5.759755e-01 | 0.240 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 5.759755e-01 | 0.240 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 5.759755e-01 | 0.240 |
| R-HSA-9609690 | HCMV Early Events | 5.781443e-01 | 0.238 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 5.781443e-01 | 0.238 |
| R-HSA-72766 | Translation | 5.795079e-01 | 0.237 |
| R-HSA-438064 | Post NMDA receptor activation events | 5.797990e-01 | 0.237 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 5.797990e-01 | 0.237 |
| R-HSA-9663891 | Selective autophagy | 5.835884e-01 | 0.234 |
| R-HSA-112310 | Neurotransmitter release cycle | 5.910655e-01 | 0.228 |
| R-HSA-73884 | Base Excision Repair | 5.910655e-01 | 0.228 |
| R-HSA-202424 | Downstream TCR signaling | 5.910655e-01 | 0.228 |
| R-HSA-1643685 | Disease | 5.942654e-01 | 0.226 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 5.947540e-01 | 0.226 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 5.984093e-01 | 0.223 |
| R-HSA-72172 | mRNA Splicing | 6.004918e-01 | 0.221 |
| R-HSA-391251 | Protein folding | 6.020320e-01 | 0.220 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 6.056222e-01 | 0.218 |
| R-HSA-1474290 | Collagen formation | 6.091802e-01 | 0.215 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 6.127063e-01 | 0.213 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 6.162008e-01 | 0.210 |
| R-HSA-72764 | Eukaryotic Translation Termination | 6.162008e-01 | 0.210 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 6.196641e-01 | 0.208 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 6.196641e-01 | 0.208 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 6.196641e-01 | 0.208 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 6.230962e-01 | 0.205 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 6.230962e-01 | 0.205 |
| R-HSA-157579 | Telomere Maintenance | 6.230962e-01 | 0.205 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 6.264977e-01 | 0.203 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 6.264977e-01 | 0.203 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 6.264977e-01 | 0.203 |
| R-HSA-418990 | Adherens junctions interactions | 6.334771e-01 | 0.198 |
| R-HSA-2408557 | Selenocysteine synthesis | 6.365201e-01 | 0.196 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 6.365201e-01 | 0.196 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 6.398012e-01 | 0.194 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 6.398012e-01 | 0.194 |
| R-HSA-192823 | Viral mRNA Translation | 6.430529e-01 | 0.192 |
| R-HSA-5683057 | MAPK family signaling cascades | 6.445248e-01 | 0.191 |
| R-HSA-112316 | Neuronal System | 6.448836e-01 | 0.191 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 6.462754e-01 | 0.190 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 6.462754e-01 | 0.190 |
| R-HSA-9833110 | RSV-host interactions | 6.494690e-01 | 0.187 |
| R-HSA-163125 | Post-translational modification: synthesis of GPI-anchored proteins | 6.494690e-01 | 0.187 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 6.513596e-01 | 0.186 |
| R-HSA-162906 | HIV Infection | 6.535460e-01 | 0.185 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 6.588791e-01 | 0.181 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 6.588791e-01 | 0.181 |
| R-HSA-9700206 | Signaling by ALK in cancer | 6.588791e-01 | 0.181 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 6.600399e-01 | 0.180 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 6.619597e-01 | 0.179 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 6.650127e-01 | 0.177 |
| R-HSA-202403 | TCR signaling | 6.680383e-01 | 0.175 |
| R-HSA-3247509 | Chromatin modifying enzymes | 6.685476e-01 | 0.175 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 6.740083e-01 | 0.171 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 6.740083e-01 | 0.171 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 6.745780e-01 | 0.171 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 6.769532e-01 | 0.169 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 6.769532e-01 | 0.169 |
| R-HSA-168249 | Innate Immune System | 6.786195e-01 | 0.168 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 6.798717e-01 | 0.168 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 6.856303e-01 | 0.164 |
| R-HSA-373760 | L1CAM interactions | 6.912860e-01 | 0.160 |
| R-HSA-9007101 | Rab regulation of trafficking | 6.940759e-01 | 0.159 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 6.968407e-01 | 0.157 |
| R-HSA-4839726 | Chromatin organization | 6.989374e-01 | 0.156 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 6.995807e-01 | 0.155 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 6.995807e-01 | 0.155 |
| R-HSA-9609646 | HCMV Infection | 7.008797e-01 | 0.154 |
| R-HSA-68875 | Mitotic Prophase | 7.022961e-01 | 0.153 |
| R-HSA-421270 | Cell-cell junction organization | 7.028116e-01 | 0.153 |
| R-HSA-73886 | Chromosome Maintenance | 7.049871e-01 | 0.152 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 7.049871e-01 | 0.152 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 7.076540e-01 | 0.150 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 7.076540e-01 | 0.150 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 7.102969e-01 | 0.149 |
| R-HSA-6809371 | Formation of the cornified envelope | 7.129161e-01 | 0.147 |
| R-HSA-162909 | Host Interactions of HIV factors | 7.129161e-01 | 0.147 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 7.180841e-01 | 0.144 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 7.180841e-01 | 0.144 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 7.180841e-01 | 0.144 |
| R-HSA-9824439 | Bacterial Infection Pathways | 7.184289e-01 | 0.144 |
| R-HSA-9734767 | Developmental Cell Lineages | 7.252000e-01 | 0.140 |
| R-HSA-416476 | G alpha (q) signalling events | 7.270004e-01 | 0.138 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 7.306036e-01 | 0.136 |
| R-HSA-9843745 | Adipogenesis | 7.354553e-01 | 0.133 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 7.378486e-01 | 0.132 |
| R-HSA-9909396 | Circadian clock | 7.378486e-01 | 0.132 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 7.494960e-01 | 0.125 |
| R-HSA-5173105 | O-linked glycosylation | 7.517630e-01 | 0.124 |
| R-HSA-422475 | Axon guidance | 7.533228e-01 | 0.123 |
| R-HSA-9948299 | Ribosome-associated quality control | 7.540097e-01 | 0.123 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 7.606293e-01 | 0.119 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 7.670720e-01 | 0.115 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 7.753951e-01 | 0.110 |
| R-HSA-9758941 | Gastrulation | 7.794452e-01 | 0.108 |
| R-HSA-5663205 | Infectious disease | 7.799661e-01 | 0.108 |
| R-HSA-392499 | Metabolism of proteins | 7.805270e-01 | 0.108 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 7.814429e-01 | 0.107 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 7.853847e-01 | 0.105 |
| R-HSA-446652 | Interleukin-1 family signaling | 7.853847e-01 | 0.105 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 7.892559e-01 | 0.103 |
| R-HSA-1989781 | PPARA activates gene expression | 7.911654e-01 | 0.102 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 7.949330e-01 | 0.100 |
| R-HSA-9610379 | HCMV Late Events | 7.949330e-01 | 0.100 |
| R-HSA-9675108 | Nervous system development | 7.956132e-01 | 0.099 |
| R-HSA-5619102 | SLC transporter disorders | 8.127820e-01 | 0.090 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 8.168454e-01 | 0.088 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 8.194817e-01 | 0.086 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 8.259432e-01 | 0.083 |
| R-HSA-1474244 | Extracellular matrix organization | 8.267645e-01 | 0.083 |
| R-HSA-2559583 | Cellular Senescence | 8.352072e-01 | 0.078 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 8.468017e-01 | 0.072 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 8.618037e-01 | 0.065 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 8.651758e-01 | 0.063 |
| R-HSA-376176 | Signaling by ROBO receptors | 8.664012e-01 | 0.062 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 8.664012e-01 | 0.062 |
| R-HSA-6805567 | Keratinization | 8.711930e-01 | 0.060 |
| R-HSA-8951664 | Neddylation | 8.876903e-01 | 0.052 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 8.902823e-01 | 0.050 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 8.926549e-01 | 0.049 |
| R-HSA-72312 | rRNA processing | 8.984379e-01 | 0.047 |
| R-HSA-418594 | G alpha (i) signalling events | 9.002257e-01 | 0.046 |
| R-HSA-8939211 | ESR-mediated signaling | 9.029793e-01 | 0.044 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.029793e-01 | 0.044 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.106596e-01 | 0.041 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 9.114657e-01 | 0.040 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.300245e-01 | 0.032 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 9.357641e-01 | 0.029 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 9.748838e-01 | 0.011 |
| R-HSA-500792 | GPCR ligand binding | 9.751787e-01 | 0.011 |
| R-HSA-388396 | GPCR downstream signalling | 9.762198e-01 | 0.010 |
| R-HSA-382551 | Transport of small molecules | 9.818190e-01 | 0.008 |
| R-HSA-5668914 | Diseases of metabolism | 9.832810e-01 | 0.007 |
| R-HSA-372790 | Signaling by GPCR | 9.870109e-01 | 0.006 |
| R-HSA-1280218 | Adaptive Immune System | 9.969243e-01 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 9.995686e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.998784e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999925e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
PRKD1 |
0.850 | 0.276 | -3 | 0.730 |
CDC7 |
0.848 | 0.134 | 1 | 0.812 |
COT |
0.843 | 0.010 | 2 | 0.833 |
PRKD2 |
0.843 | 0.200 | -3 | 0.712 |
TSSK2 |
0.843 | 0.331 | -5 | 0.868 |
TSSK1 |
0.841 | 0.301 | -3 | 0.799 |
NDR2 |
0.840 | 0.069 | -3 | 0.756 |
AMPKA1 |
0.840 | 0.217 | -3 | 0.780 |
RSK2 |
0.839 | 0.101 | -3 | 0.682 |
PIM3 |
0.838 | 0.067 | -3 | 0.735 |
CAMK1B |
0.838 | 0.122 | -3 | 0.771 |
ATR |
0.837 | 0.186 | 1 | 0.847 |
CLK3 |
0.837 | 0.117 | 1 | 0.765 |
AMPKA2 |
0.836 | 0.199 | -3 | 0.753 |
LATS2 |
0.836 | 0.090 | -5 | 0.704 |
MOS |
0.836 | 0.057 | 1 | 0.820 |
PRPK |
0.835 | -0.076 | -1 | 0.823 |
MAPKAPK2 |
0.834 | 0.113 | -3 | 0.658 |
MAPKAPK3 |
0.833 | 0.113 | -3 | 0.700 |
P90RSK |
0.833 | 0.065 | -3 | 0.664 |
NUAK2 |
0.833 | 0.123 | -3 | 0.763 |
MARK4 |
0.832 | 0.127 | 4 | 0.846 |
CAMK2G |
0.832 | 0.015 | 2 | 0.807 |
PIM1 |
0.832 | 0.100 | -3 | 0.697 |
CAMK2D |
0.832 | 0.118 | -3 | 0.745 |
SKMLCK |
0.832 | 0.103 | -2 | 0.855 |
RSK3 |
0.830 | 0.046 | -3 | 0.670 |
GCN2 |
0.830 | -0.127 | 2 | 0.771 |
PDHK4 |
0.829 | -0.188 | 1 | 0.762 |
ATM |
0.828 | 0.187 | 1 | 0.830 |
CAMK2B |
0.828 | 0.150 | 2 | 0.771 |
NDR1 |
0.828 | 0.024 | -3 | 0.752 |
CHK1 |
0.828 | 0.262 | -3 | 0.769 |
PRKD3 |
0.828 | 0.159 | -3 | 0.675 |
WNK1 |
0.828 | 0.081 | -2 | 0.875 |
HUNK |
0.828 | 0.041 | 2 | 0.810 |
CAMLCK |
0.827 | 0.061 | -2 | 0.868 |
BMPR2 |
0.827 | -0.107 | -2 | 0.890 |
TBK1 |
0.827 | -0.112 | 1 | 0.622 |
IKKB |
0.827 | -0.118 | -2 | 0.754 |
MELK |
0.827 | 0.152 | -3 | 0.736 |
PKN3 |
0.827 | 0.023 | -3 | 0.716 |
CAMK2A |
0.827 | 0.148 | 2 | 0.781 |
ULK2 |
0.826 | -0.125 | 2 | 0.763 |
NIK |
0.826 | 0.060 | -3 | 0.793 |
RAF1 |
0.826 | -0.139 | 1 | 0.741 |
GRK5 |
0.825 | -0.054 | -3 | 0.750 |
SMG1 |
0.825 | 0.208 | 1 | 0.827 |
PDHK1 |
0.825 | -0.134 | 1 | 0.743 |
PKACG |
0.824 | 0.050 | -2 | 0.761 |
DAPK2 |
0.824 | 0.059 | -3 | 0.764 |
GRK6 |
0.824 | 0.032 | 1 | 0.753 |
SRPK1 |
0.824 | 0.013 | -3 | 0.637 |
SIK |
0.823 | 0.127 | -3 | 0.688 |
NUAK1 |
0.823 | 0.107 | -3 | 0.724 |
HIPK4 |
0.823 | 0.021 | 1 | 0.727 |
CAMK4 |
0.823 | 0.089 | -3 | 0.754 |
TGFBR2 |
0.823 | -0.003 | -2 | 0.808 |
FAM20C |
0.822 | 0.066 | 2 | 0.591 |
RIPK3 |
0.822 | -0.047 | 3 | 0.699 |
DSTYK |
0.822 | -0.113 | 2 | 0.822 |
CDKL1 |
0.822 | -0.042 | -3 | 0.675 |
CHAK2 |
0.822 | -0.023 | -1 | 0.821 |
QSK |
0.822 | 0.128 | 4 | 0.818 |
MTOR |
0.822 | -0.178 | 1 | 0.685 |
IKKE |
0.822 | -0.147 | 1 | 0.610 |
NIM1 |
0.822 | 0.018 | 3 | 0.765 |
NLK |
0.821 | -0.058 | 1 | 0.724 |
PKN2 |
0.821 | 0.030 | -3 | 0.756 |
PAK6 |
0.820 | 0.145 | -2 | 0.737 |
P70S6KB |
0.820 | 0.017 | -3 | 0.708 |
PKCD |
0.820 | 0.034 | 2 | 0.736 |
LATS1 |
0.820 | 0.094 | -3 | 0.762 |
ERK5 |
0.819 | -0.051 | 1 | 0.676 |
MNK2 |
0.819 | 0.101 | -2 | 0.814 |
SSTK |
0.819 | 0.205 | 4 | 0.795 |
AURC |
0.818 | 0.076 | -2 | 0.679 |
PAK1 |
0.818 | 0.047 | -2 | 0.792 |
IKKA |
0.818 | -0.051 | -2 | 0.726 |
PAK3 |
0.818 | 0.037 | -2 | 0.800 |
NEK6 |
0.818 | -0.079 | -2 | 0.881 |
GRK1 |
0.818 | -0.000 | -2 | 0.726 |
WNK3 |
0.818 | -0.097 | 1 | 0.740 |
BRSK1 |
0.818 | 0.078 | -3 | 0.717 |
QIK |
0.818 | 0.082 | -3 | 0.745 |
DNAPK |
0.817 | 0.189 | 1 | 0.724 |
GRK4 |
0.817 | -0.063 | -2 | 0.802 |
RSK4 |
0.817 | 0.056 | -3 | 0.645 |
MASTL |
0.817 | -0.158 | -2 | 0.820 |
ULK1 |
0.816 | -0.155 | -3 | 0.702 |
MARK2 |
0.816 | 0.125 | 4 | 0.740 |
SRPK2 |
0.815 | -0.005 | -3 | 0.559 |
CDKL5 |
0.815 | -0.051 | -3 | 0.667 |
MST4 |
0.815 | -0.035 | 2 | 0.765 |
BMPR1B |
0.815 | 0.075 | 1 | 0.725 |
PKACB |
0.815 | 0.080 | -2 | 0.701 |
BCKDK |
0.815 | -0.105 | -1 | 0.760 |
MARK3 |
0.815 | 0.122 | 4 | 0.776 |
NEK7 |
0.815 | -0.176 | -3 | 0.716 |
MSK2 |
0.815 | -0.015 | -3 | 0.626 |
MNK1 |
0.815 | 0.108 | -2 | 0.820 |
MSK1 |
0.815 | 0.041 | -3 | 0.639 |
KIS |
0.815 | -0.026 | 1 | 0.598 |
MLK1 |
0.814 | -0.152 | 2 | 0.750 |
PKG2 |
0.814 | 0.084 | -2 | 0.705 |
PRKX |
0.814 | 0.108 | -3 | 0.631 |
ALK4 |
0.814 | 0.018 | -2 | 0.827 |
RIPK1 |
0.814 | -0.082 | 1 | 0.778 |
TGFBR1 |
0.814 | 0.041 | -2 | 0.791 |
BRSK2 |
0.814 | 0.052 | -3 | 0.750 |
MYLK4 |
0.813 | 0.053 | -2 | 0.787 |
ICK |
0.813 | -0.044 | -3 | 0.720 |
CLK4 |
0.813 | 0.043 | -3 | 0.681 |
CAMK1D |
0.812 | 0.123 | -3 | 0.635 |
MARK1 |
0.811 | 0.118 | 4 | 0.796 |
CLK1 |
0.811 | 0.057 | -3 | 0.684 |
DCAMKL1 |
0.811 | 0.084 | -3 | 0.738 |
AURB |
0.811 | 0.059 | -2 | 0.680 |
IRE2 |
0.811 | -0.021 | 2 | 0.732 |
NEK9 |
0.811 | -0.151 | 2 | 0.787 |
PLK1 |
0.810 | -0.034 | -2 | 0.830 |
DYRK2 |
0.810 | -0.003 | 1 | 0.623 |
IRE1 |
0.810 | -0.065 | 1 | 0.770 |
CDK8 |
0.810 | -0.039 | 1 | 0.577 |
MLK2 |
0.810 | -0.107 | 2 | 0.764 |
CAMK1G |
0.809 | 0.046 | -3 | 0.668 |
SGK3 |
0.809 | 0.049 | -3 | 0.680 |
PAK2 |
0.809 | 0.004 | -2 | 0.780 |
PLK3 |
0.809 | 0.003 | 2 | 0.754 |
PIM2 |
0.808 | 0.036 | -3 | 0.659 |
ANKRD3 |
0.808 | -0.156 | 1 | 0.784 |
VRK2 |
0.808 | -0.079 | 1 | 0.813 |
PKR |
0.808 | -0.032 | 1 | 0.798 |
ACVR2A |
0.808 | 0.025 | -2 | 0.811 |
DLK |
0.807 | -0.197 | 1 | 0.747 |
ACVR2B |
0.807 | 0.019 | -2 | 0.816 |
TTBK2 |
0.806 | -0.164 | 2 | 0.682 |
SRPK3 |
0.806 | -0.036 | -3 | 0.594 |
ALK2 |
0.806 | 0.038 | -2 | 0.799 |
MEK1 |
0.806 | -0.117 | 2 | 0.809 |
PKCB |
0.806 | -0.010 | 2 | 0.667 |
CDK7 |
0.806 | -0.035 | 1 | 0.577 |
PKACA |
0.805 | 0.068 | -2 | 0.657 |
TLK2 |
0.805 | -0.022 | 1 | 0.747 |
BUB1 |
0.805 | 0.310 | -5 | 0.887 |
AKT2 |
0.805 | 0.019 | -3 | 0.607 |
CLK2 |
0.805 | 0.055 | -3 | 0.669 |
JNK2 |
0.804 | 0.024 | 1 | 0.510 |
DCAMKL2 |
0.804 | 0.066 | -3 | 0.765 |
MLK3 |
0.804 | -0.088 | 2 | 0.675 |
PKCA |
0.804 | -0.019 | 2 | 0.664 |
JNK3 |
0.804 | 0.002 | 1 | 0.553 |
CDK19 |
0.803 | -0.043 | 1 | 0.540 |
BMPR1A |
0.803 | 0.075 | 1 | 0.723 |
PHKG1 |
0.803 | -0.037 | -3 | 0.751 |
MAPKAPK5 |
0.803 | -0.071 | -3 | 0.586 |
PKCZ |
0.802 | -0.035 | 2 | 0.719 |
GRK7 |
0.802 | -0.009 | 1 | 0.685 |
PKCH |
0.802 | -0.037 | 2 | 0.670 |
SNRK |
0.801 | -0.086 | 2 | 0.659 |
WNK4 |
0.801 | 0.004 | -2 | 0.880 |
PKCG |
0.801 | -0.053 | 2 | 0.675 |
CAMK1A |
0.801 | 0.120 | -3 | 0.599 |
AURA |
0.801 | 0.015 | -2 | 0.646 |
CHAK1 |
0.799 | -0.127 | 2 | 0.731 |
PERK |
0.799 | -0.071 | -2 | 0.849 |
NEK2 |
0.798 | -0.130 | 2 | 0.749 |
IRAK4 |
0.798 | -0.023 | 1 | 0.785 |
BRAF |
0.798 | -0.035 | -4 | 0.819 |
P38A |
0.798 | -0.019 | 1 | 0.587 |
YSK4 |
0.798 | -0.172 | 1 | 0.671 |
SMMLCK |
0.798 | 0.011 | -3 | 0.716 |
HIPK1 |
0.797 | 0.001 | 1 | 0.642 |
PAK4 |
0.797 | 0.068 | -2 | 0.660 |
PLK4 |
0.797 | -0.090 | 2 | 0.641 |
P70S6K |
0.797 | -0.019 | -3 | 0.605 |
TLK1 |
0.797 | -0.034 | -2 | 0.822 |
HRI |
0.796 | -0.106 | -2 | 0.876 |
CDK13 |
0.796 | -0.068 | 1 | 0.551 |
AKT1 |
0.796 | 0.033 | -3 | 0.634 |
PAK5 |
0.796 | 0.057 | -2 | 0.660 |
P38B |
0.796 | -0.009 | 1 | 0.515 |
CDK18 |
0.795 | -0.024 | 1 | 0.515 |
PASK |
0.795 | 0.009 | -3 | 0.739 |
CDK5 |
0.795 | -0.041 | 1 | 0.597 |
DYRK1A |
0.795 | -0.035 | 1 | 0.649 |
DAPK3 |
0.795 | 0.076 | -3 | 0.722 |
HIPK2 |
0.794 | -0.009 | 1 | 0.540 |
DYRK4 |
0.794 | -0.003 | 1 | 0.544 |
GRK2 |
0.794 | -0.081 | -2 | 0.690 |
MLK4 |
0.794 | -0.149 | 2 | 0.661 |
CDK1 |
0.794 | -0.043 | 1 | 0.531 |
PRP4 |
0.794 | -0.043 | -3 | 0.643 |
CK2A2 |
0.794 | 0.080 | 1 | 0.655 |
P38D |
0.793 | 0.019 | 1 | 0.500 |
P38G |
0.793 | -0.021 | 1 | 0.446 |
PHKG2 |
0.793 | -0.011 | -3 | 0.755 |
SBK |
0.792 | 0.056 | -3 | 0.504 |
DRAK1 |
0.792 | -0.122 | 1 | 0.691 |
NEK5 |
0.791 | -0.090 | 1 | 0.777 |
CDK9 |
0.791 | -0.072 | 1 | 0.560 |
PKCT |
0.791 | -0.037 | 2 | 0.677 |
HIPK3 |
0.791 | -0.025 | 1 | 0.619 |
DYRK3 |
0.790 | -0.008 | 1 | 0.655 |
MPSK1 |
0.790 | -0.014 | 1 | 0.730 |
CHK2 |
0.790 | 0.040 | -3 | 0.574 |
PINK1 |
0.790 | -0.178 | 1 | 0.759 |
DYRK1B |
0.790 | -0.022 | 1 | 0.570 |
CDK12 |
0.789 | -0.066 | 1 | 0.523 |
GSK3B |
0.789 | 0.005 | 4 | 0.484 |
CDK2 |
0.789 | -0.072 | 1 | 0.603 |
MEK5 |
0.788 | -0.257 | 2 | 0.779 |
MEKK1 |
0.788 | -0.209 | 1 | 0.738 |
ERK2 |
0.788 | -0.072 | 1 | 0.563 |
ERK1 |
0.788 | -0.055 | 1 | 0.509 |
MEKK2 |
0.787 | -0.154 | 2 | 0.764 |
CDK17 |
0.787 | -0.047 | 1 | 0.457 |
PLK2 |
0.787 | 0.033 | -3 | 0.748 |
SGK1 |
0.787 | 0.019 | -3 | 0.521 |
IRAK1 |
0.787 | -0.146 | -1 | 0.727 |
DAPK1 |
0.787 | 0.032 | -3 | 0.691 |
PKN1 |
0.786 | 0.002 | -3 | 0.641 |
MRCKA |
0.786 | 0.054 | -3 | 0.686 |
CK1E |
0.786 | -0.090 | -3 | 0.474 |
CDK3 |
0.785 | -0.014 | 1 | 0.476 |
ZAK |
0.785 | -0.200 | 1 | 0.704 |
GSK3A |
0.785 | 0.009 | 4 | 0.493 |
CDK14 |
0.785 | -0.031 | 1 | 0.551 |
MEKK3 |
0.785 | -0.229 | 1 | 0.710 |
PKCI |
0.785 | -0.045 | 2 | 0.679 |
ROCK2 |
0.785 | 0.076 | -3 | 0.713 |
PKCE |
0.785 | -0.006 | 2 | 0.663 |
GAK |
0.784 | -0.016 | 1 | 0.770 |
GRK3 |
0.784 | -0.063 | -2 | 0.636 |
TTBK1 |
0.783 | -0.153 | 2 | 0.614 |
MST3 |
0.783 | -0.111 | 2 | 0.757 |
AKT3 |
0.782 | 0.004 | -3 | 0.541 |
CK2A1 |
0.782 | 0.043 | 1 | 0.630 |
PDK1 |
0.782 | -0.089 | 1 | 0.733 |
MRCKB |
0.782 | 0.034 | -3 | 0.667 |
JNK1 |
0.781 | -0.020 | 1 | 0.502 |
TAO3 |
0.781 | -0.123 | 1 | 0.702 |
CAMKK1 |
0.781 | -0.179 | -2 | 0.760 |
DMPK1 |
0.781 | 0.104 | -3 | 0.710 |
CK1D |
0.780 | -0.078 | -3 | 0.427 |
LKB1 |
0.780 | -0.107 | -3 | 0.723 |
PKG1 |
0.780 | 0.036 | -2 | 0.650 |
CK1G1 |
0.780 | -0.105 | -3 | 0.469 |
VRK1 |
0.780 | -0.043 | 2 | 0.834 |
CK1A2 |
0.779 | -0.071 | -3 | 0.424 |
TAO2 |
0.779 | -0.114 | 2 | 0.795 |
EEF2K |
0.778 | -0.065 | 3 | 0.760 |
NEK8 |
0.778 | -0.193 | 2 | 0.764 |
CDK10 |
0.777 | -0.038 | 1 | 0.543 |
CAMKK2 |
0.777 | -0.160 | -2 | 0.758 |
CDK16 |
0.777 | -0.036 | 1 | 0.478 |
CRIK |
0.776 | 0.056 | -3 | 0.622 |
NEK4 |
0.775 | -0.163 | 1 | 0.714 |
NEK1 |
0.774 | -0.090 | 1 | 0.742 |
LRRK2 |
0.774 | -0.134 | 2 | 0.791 |
PBK |
0.773 | 0.008 | 1 | 0.694 |
TNIK |
0.771 | -0.097 | 3 | 0.778 |
HGK |
0.771 | -0.135 | 3 | 0.777 |
ERK7 |
0.771 | -0.075 | 2 | 0.444 |
NEK11 |
0.771 | -0.276 | 1 | 0.686 |
MST2 |
0.770 | -0.181 | 1 | 0.695 |
PDHK3_TYR |
0.770 | 0.172 | 4 | 0.906 |
LOK |
0.770 | -0.092 | -2 | 0.794 |
MAP3K15 |
0.770 | -0.159 | 1 | 0.683 |
MOK |
0.770 | -0.018 | 1 | 0.663 |
MEKK6 |
0.770 | -0.158 | 1 | 0.693 |
MAK |
0.769 | -0.026 | -2 | 0.684 |
ROCK1 |
0.769 | 0.037 | -3 | 0.682 |
MINK |
0.769 | -0.168 | 1 | 0.680 |
STK33 |
0.768 | -0.150 | 2 | 0.594 |
TAK1 |
0.768 | -0.177 | 1 | 0.721 |
MEK2 |
0.768 | -0.206 | 2 | 0.784 |
RIPK2 |
0.768 | -0.193 | 1 | 0.668 |
CDK4 |
0.767 | -0.058 | 1 | 0.514 |
GCK |
0.767 | -0.175 | 1 | 0.663 |
CDK6 |
0.766 | -0.067 | 1 | 0.536 |
BIKE |
0.765 | 0.045 | 1 | 0.666 |
TTK |
0.764 | -0.006 | -2 | 0.827 |
MST1 |
0.764 | -0.175 | 1 | 0.681 |
KHS1 |
0.763 | -0.103 | 1 | 0.659 |
HPK1 |
0.763 | -0.155 | 1 | 0.649 |
YSK1 |
0.762 | -0.146 | 2 | 0.739 |
HASPIN |
0.762 | 0.004 | -1 | 0.675 |
SLK |
0.761 | -0.133 | -2 | 0.719 |
NEK3 |
0.760 | -0.161 | 1 | 0.694 |
PKMYT1_TYR |
0.760 | -0.014 | 3 | 0.810 |
TESK1_TYR |
0.759 | -0.046 | 3 | 0.832 |
LIMK2_TYR |
0.758 | 0.062 | -3 | 0.804 |
MAP2K4_TYR |
0.758 | -0.067 | -1 | 0.838 |
KHS2 |
0.758 | -0.103 | 1 | 0.662 |
PDHK4_TYR |
0.757 | -0.014 | 2 | 0.831 |
MAP2K6_TYR |
0.757 | -0.065 | -1 | 0.835 |
MAP2K7_TYR |
0.756 | -0.157 | 2 | 0.826 |
AAK1 |
0.755 | 0.091 | 1 | 0.570 |
ALPHAK3 |
0.755 | -0.059 | -1 | 0.721 |
PDHK1_TYR |
0.752 | -0.090 | -1 | 0.850 |
ASK1 |
0.752 | -0.150 | 1 | 0.677 |
YANK3 |
0.751 | -0.081 | 2 | 0.386 |
BMPR2_TYR |
0.751 | -0.101 | -1 | 0.806 |
MYO3B |
0.750 | -0.110 | 2 | 0.753 |
PINK1_TYR |
0.750 | -0.195 | 1 | 0.770 |
EPHA6 |
0.750 | -0.010 | -1 | 0.815 |
OSR1 |
0.749 | -0.185 | 2 | 0.734 |
EPHB4 |
0.749 | -0.019 | -1 | 0.812 |
RET |
0.747 | -0.105 | 1 | 0.729 |
LIMK1_TYR |
0.747 | -0.138 | 2 | 0.819 |
TYRO3 |
0.746 | -0.073 | 3 | 0.745 |
YES1 |
0.746 | -0.031 | -1 | 0.843 |
TNK2 |
0.745 | -0.006 | 3 | 0.701 |
DDR1 |
0.744 | -0.103 | 4 | 0.818 |
TAO1 |
0.744 | -0.149 | 1 | 0.639 |
TYK2 |
0.744 | -0.154 | 1 | 0.722 |
TXK |
0.743 | 0.010 | 1 | 0.749 |
JAK2 |
0.742 | -0.129 | 1 | 0.714 |
ABL2 |
0.742 | -0.047 | -1 | 0.782 |
MYO3A |
0.742 | -0.174 | 1 | 0.705 |
EPHB1 |
0.741 | -0.028 | 1 | 0.763 |
MST1R |
0.741 | -0.145 | 3 | 0.746 |
ROS1 |
0.741 | -0.123 | 3 | 0.719 |
FGR |
0.741 | -0.076 | 1 | 0.750 |
SRMS |
0.740 | -0.044 | 1 | 0.768 |
EPHB2 |
0.740 | -0.008 | -1 | 0.791 |
EPHB3 |
0.740 | -0.027 | -1 | 0.801 |
ABL1 |
0.740 | -0.048 | -1 | 0.777 |
EPHA4 |
0.740 | -0.042 | 2 | 0.749 |
CSF1R |
0.739 | -0.130 | 3 | 0.734 |
CK1A |
0.739 | -0.115 | -3 | 0.347 |
FER |
0.739 | -0.106 | 1 | 0.790 |
TNK1 |
0.737 | -0.043 | 3 | 0.731 |
HCK |
0.737 | -0.073 | -1 | 0.806 |
INSRR |
0.736 | -0.131 | 3 | 0.701 |
ITK |
0.735 | -0.082 | -1 | 0.772 |
AXL |
0.735 | -0.075 | 3 | 0.723 |
STLK3 |
0.735 | -0.228 | 1 | 0.668 |
JAK3 |
0.735 | -0.160 | 1 | 0.726 |
MERTK |
0.734 | -0.050 | 3 | 0.730 |
BLK |
0.734 | -0.024 | -1 | 0.815 |
TNNI3K_TYR |
0.734 | -0.046 | 1 | 0.756 |
LCK |
0.734 | -0.053 | -1 | 0.803 |
FGFR2 |
0.733 | -0.153 | 3 | 0.748 |
TEK |
0.732 | -0.114 | 3 | 0.700 |
FLT3 |
0.732 | -0.134 | 3 | 0.739 |
PDGFRB |
0.731 | -0.169 | 3 | 0.742 |
FGFR1 |
0.731 | -0.139 | 3 | 0.723 |
KIT |
0.731 | -0.158 | 3 | 0.741 |
NEK10_TYR |
0.730 | -0.134 | 1 | 0.601 |
BMX |
0.730 | -0.061 | -1 | 0.696 |
LTK |
0.730 | -0.086 | 3 | 0.702 |
EPHA7 |
0.730 | -0.059 | 2 | 0.748 |
TEC |
0.729 | -0.063 | -1 | 0.729 |
BTK |
0.729 | -0.130 | -1 | 0.759 |
FYN |
0.728 | -0.037 | -1 | 0.773 |
KDR |
0.728 | -0.148 | 3 | 0.698 |
PTK6 |
0.728 | -0.128 | -1 | 0.706 |
PDGFRA |
0.728 | -0.168 | 3 | 0.740 |
JAK1 |
0.727 | -0.123 | 1 | 0.658 |
ALK |
0.727 | -0.121 | 3 | 0.676 |
DDR2 |
0.727 | -0.045 | 3 | 0.689 |
EPHA3 |
0.727 | -0.107 | 2 | 0.728 |
EPHA1 |
0.726 | -0.083 | 3 | 0.692 |
PTK2B |
0.725 | -0.058 | -1 | 0.762 |
FRK |
0.725 | -0.073 | -1 | 0.824 |
CK1G3 |
0.725 | -0.094 | -3 | 0.300 |
LYN |
0.725 | -0.071 | 3 | 0.683 |
EPHA5 |
0.723 | -0.061 | 2 | 0.737 |
WEE1_TYR |
0.723 | -0.132 | -1 | 0.714 |
NTRK1 |
0.722 | -0.204 | -1 | 0.775 |
MET |
0.722 | -0.176 | 3 | 0.722 |
SRC |
0.721 | -0.079 | -1 | 0.785 |
FLT1 |
0.720 | -0.168 | -1 | 0.773 |
ERBB2 |
0.720 | -0.180 | 1 | 0.674 |
FGFR3 |
0.719 | -0.188 | 3 | 0.719 |
FLT4 |
0.719 | -0.178 | 3 | 0.711 |
NTRK2 |
0.719 | -0.203 | 3 | 0.704 |
CSK |
0.718 | -0.113 | 2 | 0.758 |
EPHA8 |
0.717 | -0.106 | -1 | 0.771 |
INSR |
0.716 | -0.195 | 3 | 0.679 |
EGFR |
0.716 | -0.102 | 1 | 0.596 |
NTRK3 |
0.716 | -0.170 | -1 | 0.733 |
YANK2 |
0.715 | -0.112 | 2 | 0.405 |
MATK |
0.713 | -0.169 | -1 | 0.706 |
FGFR4 |
0.711 | -0.136 | -1 | 0.733 |
EPHA2 |
0.708 | -0.112 | -1 | 0.729 |
PTK2 |
0.707 | -0.098 | -1 | 0.709 |
SYK |
0.706 | -0.098 | -1 | 0.711 |
MUSK |
0.705 | -0.152 | 1 | 0.581 |
ERBB4 |
0.702 | -0.108 | 1 | 0.612 |
IGF1R |
0.702 | -0.185 | 3 | 0.639 |
CK1G2 |
0.696 | -0.129 | -3 | 0.391 |
FES |
0.692 | -0.163 | -1 | 0.671 |
ZAP70 |
0.677 | -0.154 | -1 | 0.623 |