Motif 837 (n=162)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A5YKK6 | CNOT1 | S1703 | ochoa | CCR4-NOT transcription complex subunit 1 (CCR4-associated factor 1) (Negative regulator of transcription subunit 1 homolog) (NOT1H) (hNOT1) | Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of embryonic stem (ES) cell identity. Plays a role in rapid sperm motility via mediating timely mRNA turnover (By similarity). {ECO:0000250|UniProtKB:Q6ZQ08, ECO:0000269|PubMed:10637334, ECO:0000269|PubMed:16778766, ECO:0000269|PubMed:21278420, ECO:0000269|PubMed:21976065, ECO:0000269|PubMed:21984185, ECO:0000269|PubMed:22367759, ECO:0000269|PubMed:23644599, ECO:0000269|PubMed:27558897, ECO:0000269|PubMed:32354837}. |
| H3BM21 | None | S92 | ochoa | Integrin beta | None |
| H7C1W4 | None | S58 | ochoa | Uncharacterized protein | None |
| O00151 | PDLIM1 | S90 | ochoa | PDZ and LIM domain protein 1 (C-terminal LIM domain protein 1) (Elfin) (LIM domain protein CLP-36) | Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (PubMed:10861853). Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts (By similarity). {ECO:0000250|UniProtKB:P52944, ECO:0000269|PubMed:10861853}. |
| O00622 | CCN1 | S205 | ochoa | CCN family member 1 (Cellular communication network factor 1) (Cysteine-rich angiogenic inducer 61) (Insulin-like growth factor-binding protein 10) (IBP-10) (IGF-binding protein 10) (IGFBP-10) (Protein CYR61) (Protein GIG1) | Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CCN1-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. {ECO:0000269|PubMed:11584015}. |
| O60347 | TBC1D12 | S187 | ochoa | TBC1 domain family member 12 | RAB11A-binding protein that plays a role in neurite outgrowth. {ECO:0000250|UniProtKB:M0R7T9}. |
| O75037 | KIF21B | S1215 | ochoa | Kinesin-like protein KIF21B | Plus-end directed microtubule-dependent motor protein which displays processive activity. Is involved in regulation of microtubule dynamics, synapse function and neuronal morphology, including dendritic tree branching and spine formation. Plays a role in lerning and memory. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptor to cell surface. {ECO:0000250|UniProtKB:Q9QXL1}. |
| O75122 | CLASP2 | S892 | ochoa | CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (Protein Orbit homolog 2) (hOrbit2) | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16824950, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:26003921}. |
| O75140 | DEPDC5 | S524 | ochoa | GATOR1 complex protein DEPDC5 (DEP domain-containing protein 5) | As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the mTORC1 pathway (PubMed:23723238, PubMed:25457612, PubMed:29590090, PubMed:29769719, PubMed:31548394, PubMed:35338845). In response to amino acid depletion, the GATOR1 complex has GTPase activating protein (GAP) activity and strongly increases GTP hydrolysis by RagA/RRAGA (or RagB/RRAGB) within heterodimeric Rag complexes, thereby turning them into their inactive GDP-bound form, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling (PubMed:23723238, PubMed:25457612, PubMed:29590090, PubMed:29769719, PubMed:35338845). In the presence of abundant amino acids, the GATOR1 complex is negatively regulated by GATOR2, the other GATOR subcomplex, in this amino acid-sensing branch of the TORC1 pathway (PubMed:23723238, PubMed:25457612, PubMed:29769719). Within the GATOR1 complex, DEPDC5 mediates direct interaction with the nucleotide-binding pocket of small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD) and coordinates their nucleotide loading states by promoting RagA/RRAGA or RagB/RRAGB into their GDP-binding state and RagC/RRAGC or RagD/RRAGD into their GTP-binding state (PubMed:29590090, PubMed:35338845). However, it does not execute the GAP activity, which is mediated by NPRL2 (PubMed:29590090). {ECO:0000269|PubMed:23723238, ECO:0000269|PubMed:25457612, ECO:0000269|PubMed:29590090, ECO:0000269|PubMed:29769719, ECO:0000269|PubMed:31548394, ECO:0000269|PubMed:35338845}. |
| O75417 | POLQ | S1651 | ochoa | DNA polymerase theta (DNA polymerase eta) [Includes: Helicase POLQ (EC 3.6.4.12); DNA polymerase POLQ (EC 2.7.7.7) (RNA-directed DNA polymerase POLQ) (EC 2.7.7.49)] | Low-fidelity DNA polymerase with a helicase activity that promotes microhomology-mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery required to repair double-strand breaks in DNA during mitosis (PubMed:14576298, PubMed:18503084, PubMed:24648516, PubMed:25642963, PubMed:25643323, PubMed:25775267, PubMed:26636256, PubMed:27311885, PubMed:27591252, PubMed:30655289, PubMed:31562312, PubMed:32873648, PubMed:34140467, PubMed:34179826, PubMed:36455556, PubMed:37440612, PubMed:37674080). MMEJ is an error-prone repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements, such as telomere fusions, some of them leading to cellular transformation (PubMed:25642963, PubMed:25643323, PubMed:25775267, PubMed:27311885, PubMed:27591252, PubMed:31562312, PubMed:32873648). MMEJ is required during mitosis to repair persistent double-strand breaks that originate in S-phase (PubMed:37440612, PubMed:37674080). Although error-prone, MMEJ protects against chromosomal instability and tumorigenesis (By similarity). The polymerase acts by binding directly the 2 ends of resected double-strand breaks, allowing microhomologous sequences in the overhangs to form base pairs (PubMed:25643323, PubMed:25775267, PubMed:27311885, PubMed:27591252). It then extends each strand from the base-paired region using the opposing overhang as a template (PubMed:25643323, PubMed:25775267, PubMed:27311885, PubMed:27591252). Requires partially resected DNA containing 2 to 6 base pairs of microhomology to perform MMEJ (PubMed:25643323, PubMed:25775267, PubMed:27311885, PubMed:27591252). The polymerase lacks proofreading activity and is highly promiscuous: unlike most polymerases, promotes extension of ssDNA and partial ssDNA (pssDNA) substrates (PubMed:18503084, PubMed:21050863, PubMed:22135286). When the ends of a break do not contain terminal microhomology must identify embedded complementary sequences through a scanning step (PubMed:32234782). Also acts as a DNA helicase, promoting dissociation of the replication protein A complex (RPA/RP-A), composed of RPA1, RPA2 and RPA3, from resected double-strand breaks to allow their annealing and subsequent joining by MMEJ (PubMed:36455556). Removal of RPA/RP-A complex proteins prevents RAD51 accumulation at resected ends, thereby inhibiting homology-recombination repair (HR) pathway (PubMed:25642963, PubMed:28695890). Also shows RNA-directed DNA polymerase activity to mediate DNA repair in vitro; however this activity needs additional evidence in vivo (PubMed:34117057). May also have lyase activity (PubMed:19188258). Involved in somatic hypermutation of immunoglobulin genes, a process that requires the activity of DNA polymerases to ultimately introduce mutations at both A/T and C/G base pairs (By similarity). POLQ-mediated end joining activity is involved in random integration of exogenous DNA hampers (PubMed:28695890). {ECO:0000250|UniProtKB:Q8CGS6, ECO:0000269|PubMed:14576298, ECO:0000269|PubMed:18503084, ECO:0000269|PubMed:19188258, ECO:0000269|PubMed:21050863, ECO:0000269|PubMed:22135286, ECO:0000269|PubMed:24648516, ECO:0000269|PubMed:25642963, ECO:0000269|PubMed:25643323, ECO:0000269|PubMed:25775267, ECO:0000269|PubMed:26636256, ECO:0000269|PubMed:27311885, ECO:0000269|PubMed:27591252, ECO:0000269|PubMed:28695890, ECO:0000269|PubMed:30655289, ECO:0000269|PubMed:31562312, ECO:0000269|PubMed:32234782, ECO:0000269|PubMed:32873648, ECO:0000269|PubMed:34117057, ECO:0000269|PubMed:34140467, ECO:0000269|PubMed:34179826, ECO:0000269|PubMed:36455556, ECO:0000269|PubMed:37440612, ECO:0000269|PubMed:37674080}. |
| O75832 | PSMD10 | S75 | ochoa | 26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin) (p28(GANK)) | Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pathway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis.; FUNCTION: Acts as an proto-oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4. Facilitates binding of MDM2 to p53/TP53 and the mono- and polyubiquitination of p53/TP53 by MDM2 suggesting a function in targeting the TP53:MDM2 complex to the 26S proteasome. Involved in p53-independent apoptosis. Involved in regulation of NF-kappa-B by retaining it in the cytoplasm. Binds to the NF-kappa-B component RELA and accelerates its XPO1/CRM1-mediated nuclear export. |
| O94915 | FRYL | S1258 | ochoa | Protein furry homolog-like (ALL1-fused gene from chromosome 4p12 protein) | Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching (By similarity). May function as a transcriptional activator. {ECO:0000250, ECO:0000269|PubMed:16061630}. |
| O94955 | RHOBTB3 | S32 | ochoa | Rho-related BTB domain-containing protein 3 (EC 3.6.1.-) | Rab9-regulated ATPase required for endosome to Golgi transport. Involved in transport vesicle docking at the Golgi complex, possibly by participating in release M6PRBP1/TIP47 from vesicles to permit their efficient docking and fusion at the Golgi. Specifically binds Rab9, but not other Rab proteins. Has low intrinsic ATPase activity due to autoinhibition, which is relieved by Rab9. {ECO:0000269|PubMed:19490898}. |
| O94967 | WDR47 | S326 | ochoa | WD repeat-containing protein 47 (Neuronal enriched MAP-interacting protein) (Nemitin) | None |
| O94979 | SEC31A | S251 | ochoa | Protein transport protein Sec31A (ABP125) (ABP130) (SEC31-like protein 1) (SEC31-related protein A) (Web1-like protein) | Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER) (PubMed:10788476). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). {ECO:0000250|UniProtKB:Q9Z2Q1, ECO:0000269|PubMed:10788476}. |
| O95235 | KIF20A | S867 | ochoa|psp | Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6) | Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:12939256}. |
| O95758 | PTBP3 | S454 | ochoa | Polypyrimidine tract-binding protein 3 (Regulator of differentiation 1) (Rod1) | RNA-binding protein that mediates pre-mRNA alternative splicing regulation. Plays a role in the regulation of cell proliferation, differentiation and migration. Positive regulator of EPO-dependent erythropoiesis. Participates in cell differentiation regulation by repressing tissue-specific exons. Promotes FAS exon 6 skipping. Binds RNA, preferentially to both poly(G) and poly(U). {ECO:0000269|PubMed:10207106, ECO:0000269|PubMed:18335065, ECO:0000269|PubMed:19441079, ECO:0000269|PubMed:20937273}. |
| O95822 | MLYCD | S471 | ochoa | Malonyl-CoA decarboxylase, mitochondrial (MCD) (EC 4.1.1.9) | Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced. In peroxisomes it may be involved in degrading intraperoxisomal malonyl-CoA, which is generated by the peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acids. Plays a role in the metabolic balance between glucose and lipid oxidation in muscle independent of alterations in insulin signaling. May play a role in controlling the extent of ischemic injury by promoting glucose oxidation. {ECO:0000269|PubMed:10455107, ECO:0000269|PubMed:15003260, ECO:0000269|PubMed:18314420, ECO:0000269|PubMed:23482565}. |
| P05106 | ITGB3 | S103 | ochoa | Integrin beta-3 (Platelet membrane glycoprotein IIIa) (GPIIIa) (CD antigen CD61) | Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain (By similarity). Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen (PubMed:9111081). This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and acts as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415, PubMed:24789099). ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (PubMed:18441324). ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling (PubMed:28302677). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:19578119). ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling (PubMed:29030430). ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGAV:ITGB3 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887). In brain, plays a role in synaptic transmission and plasticity. Involved in the regulation of the serotonin neurotransmission, is required to localize to specific compartments within the synapse the serotonin receptor SLC6A4 and for an appropriate reuptake of serotonin. Controls excitatory synaptic strength by regulating GRIA2-containing AMPAR endocytosis, which affects AMPAR abundance and composition (By similarity). ITGAV:ITGB3 act as a receptor for CD40LG (PubMed:31331973). ITGAV:ITGB3 acts as a receptor for IBSP and promotes cell adhesion and migration to IBSP (PubMed:10640428). {ECO:0000250|UniProtKB:O54890, ECO:0000269|PubMed:10640428, ECO:0000269|PubMed:12807887, ECO:0000269|PubMed:18441324, ECO:0000269|PubMed:18635536, ECO:0000269|PubMed:19578119, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:23125415, ECO:0000269|PubMed:24789099, ECO:0000269|PubMed:25398877, ECO:0000269|PubMed:28302677, ECO:0000269|PubMed:28873464, ECO:0000269|PubMed:29030430, ECO:0000269|PubMed:31331973, ECO:0000269|PubMed:9111081, ECO:0000269|PubMed:9195946, ECO:0000303|PubMed:16322781, ECO:0000303|PubMed:17635696}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Herpes virus 8/HHV-8. {ECO:0000269|PubMed:18045938}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Coxsackievirus A9. {ECO:0000269|PubMed:7519807}.; FUNCTION: (Microbial infection) Acts as a receptor for Hantaan virus. {ECO:0000269|PubMed:9618541}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Cytomegalovirus/HHV-5. {ECO:0000269|PubMed:15834425}.; FUNCTION: (Microbial infection) Integrin ITGA5:ITGB3 acts as a receptor for Human metapneumovirus. {ECO:0000269|PubMed:24478423}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts aP05556s a receptor for Human parechovirus 1. {ECO:0000269|PubMed:11160695}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for West nile virus. {ECO:0000269|PubMed:23658209}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. {ECO:0000269|PubMed:10397733}. |
| P05198 | EIF2S1 | S49 | ochoa|psp | Eukaryotic translation initiation factor 2 subunit 1 (Eukaryotic translation initiation factor 2 subunit alpha) (eIF-2-alpha) (eIF-2A) (eIF-2alpha) (eIF2-alpha) | Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:16289705, PubMed:38340717). This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex (43S PIC) (PubMed:16289705). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex (PubMed:16289705). In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B (PubMed:16289705). EIF2S1/eIF2-alpha is a key component of the integrated stress response (ISR), required for adaptation to various stress: phosphorylation by metabolic-stress sensing protein kinases (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2) in response to stress converts EIF2S1/eIF2-alpha in a global protein synthesis inhibitor, leading to an attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming (PubMed:19131336, PubMed:33384352, PubMed:38340717). EIF2S1/eIF2-alpha also acts as an activator of mitophagy in response to mitochondrial damage: phosphorylation by EIF2AK1/HRI promotes relocalization to the mitochondrial surface, thereby triggering PRKN-independent mitophagy (PubMed:38340717). {ECO:0000269|PubMed:16289705, ECO:0000269|PubMed:19131336, ECO:0000269|PubMed:33384352, ECO:0000269|PubMed:38340717}. |
| P07199 | CENPB | S307 | ochoa | Major centromere autoantigen B (Centromere protein B) (CENP-B) | Interacts with centromeric heterochromatin in chromosomes and binds to a specific 17 bp subset of alphoid satellite DNA, called the CENP-B box (PubMed:11726497). May organize arrays of centromere satellite DNA into a higher-order structure which then directs centromere formation and kinetochore assembly in mammalian chromosomes (Probable). {ECO:0000269|PubMed:11726497, ECO:0000305}. |
| P07900 | HSP90AA1 | S68 | ochoa | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}. |
| P08238 | HSP90AB1 | S63 | ochoa | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}. |
| P10242 | MYB | S599 | ochoa | Transcriptional activator Myb (Proto-oncogene c-Myb) | Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells. |
| P14923 | JUP | S182 | ochoa | Junction plakoglobin (Catenin gamma) (Desmoplakin III) (Desmoplakin-3) | Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity). {ECO:0000250}. |
| P19525 | EIF2AK2 | S83 | ochoa|psp | Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2A protein kinase 2) (Interferon-inducible RNA-dependent protein kinase) (P1/eIF-2A protein kinase) (Protein kinase RNA-activated) (PKR) (Protein kinase R) (Tyrosine-protein kinase EIF2AK2) (EC 2.7.10.2) (p68 kinase) | IFN-induced dsRNA-dependent serine/threonine-protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) and plays a key role in the innate immune response to viral infection (PubMed:18835251, PubMed:19189853, PubMed:19507191, PubMed:21072047, PubMed:21123651, PubMed:22381929, PubMed:22948139, PubMed:23229543). Inhibits viral replication via the integrated stress response (ISR): EIF2S1/eIF-2-alpha phosphorylation in response to viral infection converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, resulting to a shutdown of cellular and viral protein synthesis, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4 (PubMed:19189853, PubMed:21123651, PubMed:22948139, PubMed:23229543). Exerts its antiviral activity on a wide range of DNA and RNA viruses including hepatitis C virus (HCV), hepatitis B virus (HBV), measles virus (MV) and herpes simplex virus 1 (HHV-1) (PubMed:11836380, PubMed:19189853, PubMed:19840259, PubMed:20171114, PubMed:21710204, PubMed:23115276, PubMed:23399035). Also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation: phosphorylates other substrates including p53/TP53, PPP2R5A, DHX9, ILF3, IRS1 and the HHV-1 viral protein US11 (PubMed:11836380, PubMed:19229320, PubMed:22214662). In addition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity and phosphorylates CDK1 at 'Tyr-4' upon DNA damage, facilitating its ubiquitination and proteasomal degradation (PubMed:20395957). Either as an adapter protein and/or via its kinase activity, can regulate various signaling pathways (p38 MAP kinase, NF-kappa-B and insulin signaling pathways) and transcription factors (JUN, STAT1, STAT3, IRF1, ATF3) involved in the expression of genes encoding pro-inflammatory cytokines and IFNs (PubMed:22948139, PubMed:23084476, PubMed:23372823). Activates the NF-kappa-B pathway via interaction with IKBKB and TRAF family of proteins and activates the p38 MAP kinase pathway via interaction with MAP2K6 (PubMed:10848580, PubMed:15121867, PubMed:15229216). Can act as both a positive and negative regulator of the insulin signaling pathway (ISP) (PubMed:20685959). Negatively regulates ISP by inducing the inhibitory phosphorylation of insulin receptor substrate 1 (IRS1) at 'Ser-312' and positively regulates ISP via phosphorylation of PPP2R5A which activates FOXO1, which in turn up-regulates the expression of insulin receptor substrate 2 (IRS2) (PubMed:20685959). Can regulate NLRP3 inflammasome assembly and the activation of NLRP3, NLRP1, AIM2 and NLRC4 inflammasomes (PubMed:22801494). Plays a role in the regulation of the cytoskeleton by binding to gelsolin (GSN), sequestering the protein in an inactive conformation away from actin (By similarity). {ECO:0000250|UniProtKB:Q03963, ECO:0000269|PubMed:10848580, ECO:0000269|PubMed:11836380, ECO:0000269|PubMed:15121867, ECO:0000269|PubMed:15229216, ECO:0000269|PubMed:18835251, ECO:0000269|PubMed:19189853, ECO:0000269|PubMed:19229320, ECO:0000269|PubMed:19507191, ECO:0000269|PubMed:19840259, ECO:0000269|PubMed:20171114, ECO:0000269|PubMed:20395957, ECO:0000269|PubMed:20685959, ECO:0000269|PubMed:21072047, ECO:0000269|PubMed:21123651, ECO:0000269|PubMed:21710204, ECO:0000269|PubMed:22214662, ECO:0000269|PubMed:22381929, ECO:0000269|PubMed:22801494, ECO:0000269|PubMed:22948139, ECO:0000269|PubMed:23084476, ECO:0000269|PubMed:23115276, ECO:0000269|PubMed:23229543, ECO:0000269|PubMed:23372823, ECO:0000269|PubMed:23399035, ECO:0000269|PubMed:32197074}. |
| P21817 | RYR1 | S3566 | ochoa | Ryanodine receptor 1 (RYR-1) (RyR1) (Skeletal muscle calcium release channel) (Skeletal muscle ryanodine receptor) (Skeletal muscle-type ryanodine receptor) (Type 1 ryanodine receptor) | Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules (PubMed:11741831, PubMed:16163667, PubMed:18268335, PubMed:18650434, PubMed:26115329). Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm (PubMed:18268335). Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity). {ECO:0000250|UniProtKB:E9PZQ0, ECO:0000269|PubMed:18268335, ECO:0000269|PubMed:18650434, ECO:0000269|PubMed:26115329, ECO:0000305|PubMed:11741831, ECO:0000305|PubMed:16163667}. |
| P23258 | TUBG1 | S80 | ochoa|psp | Tubulin gamma-1 chain (Gamma-1-tubulin) (Gamma-tubulin complex component 1) (GCP-1) | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:38609661, PubMed:39321809). Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:38305685, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685, PubMed:38609661, PubMed:39321809). {ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| P24864 | CCNE1 | S103 | ochoa|psp | G1/S-specific cyclin-E1 | Essential for the control of the cell cycle at the G1/S (start) transition. {ECO:0000269|PubMed:7739542}. |
| P28749 | RBL1 | S1009 | psp | Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (p107) (pRb1) | Key regulator of entry into cell division (PubMed:17671431). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation (By similarity). Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression (By similarity). Controls histone H4 'Lys-20' trimethylation (By similarity). Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters (By similarity). Potent inhibitor of E2F-mediated trans-activation (PubMed:8319904). May act as a tumor suppressor (PubMed:8319904). {ECO:0000250|UniProtKB:Q64701, ECO:0000269|PubMed:17671431, ECO:0000269|PubMed:8319904}. |
| P35222 | CTNNB1 | S191 | ochoa|psp | Catenin beta-1 (Beta-catenin) | Key downstream component of the canonical Wnt signaling pathway (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). Also acts as a coactivator for other transcription factors, such as NR5A2 (PubMed:22187462). Promotes epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via driving transcription of CTNNB1/TCF-target genes (PubMed:29910125). Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (By similarity). Acts as a negative regulator of centrosome cohesion (PubMed:18086858). Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization (PubMed:21262353). Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (PubMed:18957423). Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity). Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, via promoting the transcription of differentiation factors such as LEF1, BMP2 and BMP4 (By similarity). Activity is repressed in a MSX1-mediated manner at the bell stage of mesenchymal tooth germ formation which prevents premature differentiation of odontoblasts (By similarity). {ECO:0000250|UniProtKB:Q02248, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:18077326, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18957423, ECO:0000269|PubMed:21262353, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22187462, ECO:0000269|PubMed:22647378, ECO:0000269|PubMed:22699938, ECO:0000269|PubMed:29910125}. |
| P46782 | RPS5 | S142 | ochoa | Small ribosomal subunit protein uS7 (40S ribosomal protein S5) [Cleaved into: Small ribosomal subunit protein uS7, N-terminally processed (40S ribosomal protein S5, N-terminally processed)] | Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| P46939 | UTRN | S2482 | ochoa | Utrophin (Dystrophin-related protein 1) (DRP-1) | May play a role in anchoring the cytoskeleton to the plasma membrane. {ECO:0000250}. |
| P47900 | P2RY1 | S252 | psp | P2Y purinoceptor 1 (P2Y1) (ADP receptor) (Purinergic receptor) | Receptor for extracellular adenine nucleotides such as ADP (PubMed:25822790, PubMed:9038354, PubMed:9442040). In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately platelet aggregation (PubMed:9442040). {ECO:0000269|PubMed:25822790, ECO:0000269|PubMed:9038354, ECO:0000269|PubMed:9442040}. |
| P48751 | SLC4A3 | S297 | ochoa | Anion exchange protein 3 (AE 3) (Anion exchanger 3) (CAE3/BAE3) (Cardiac/brain band 3-like protein) (Neuronal band 3-like protein) (Solute carrier family 4 member 3) | Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane (PubMed:29167417, PubMed:7923606). May be involved in the regulation of intracellular pH, and the modulation of cardiac action potential (PubMed:29167417). {ECO:0000269|PubMed:29167417, ECO:0000269|PubMed:7923606}. |
| P49748 | ACADVL | S522 | ochoa | Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (VLCAD) (EC 1.3.8.9) | Very long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats (PubMed:18227065, PubMed:7668252, PubMed:9461620, PubMed:9599005, PubMed:9839948). The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (PubMed:18227065, PubMed:7668252, PubMed:9461620, PubMed:9839948). Among the different mitochondrial acyl-CoA dehydrogenases, very long-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 12 to 24 carbons long primary chains (PubMed:21237683, PubMed:9839948). {ECO:0000269|PubMed:18227065, ECO:0000269|PubMed:21237683, ECO:0000269|PubMed:7668252, ECO:0000269|PubMed:9461620, ECO:0000269|PubMed:9599005, ECO:0000269|PubMed:9839948}. |
| P53618 | COPB1 | S773 | ochoa | Coatomer subunit beta (Beta-coat protein) (Beta-COP) | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Plays a functional role in facilitating the transport of kappa-type opioid receptor mRNAs into axons and enhances translation of these proteins. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte surface triglyceride lipase (PNPLA2) with the lipid droplet to mediate lipolysis (By similarity). Involved in the Golgi disassembly and reassembly processes during cell cycle. Involved in autophagy by playing a role in early endosome function. Plays a role in organellar compartmentalization of secretory compartments including endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC), Golgi, trans-Golgi network (TGN) and recycling endosomes, and in biosynthetic transport of CAV1. Promotes degradation of Nef cellular targets CD4 and MHC class I antigens by facilitating their trafficking to degradative compartments. {ECO:0000250, ECO:0000269|PubMed:18385291, ECO:0000269|PubMed:18725938, ECO:0000269|PubMed:19364919, ECO:0000269|PubMed:20056612}. |
| P54132 | BLM | S714 | psp | RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) | ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}. |
| P56524 | HDAC4 | S400 | ochoa | Histone deacetylase 4 (HD4) (EC 3.5.1.98) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1 (PubMed:27708256). {ECO:0000269|PubMed:10523670, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:27708256}. |
| P81408 | ENTREP3 | S389 | ochoa | Protein ENTREP3 (Endosomal transmembrane epsin interactor 3) (Protein COTE1) | None |
| Q03164 | KMT2A | S610 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q03164 | KMT2A | S2611 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q03989 | ARID5A | S256 | ochoa | AT-rich interactive domain-containing protein 5A (ARID domain-containing protein 5A) (Modulator recognition factor 1) (MRF-1) | DNA-binding protein that may regulate transcription and act as a repressor by binding to AT-rich stretches in the promoter region of target genes (PubMed:8649988). May positively regulate chondrocyte-specific transcription such as of COL2A1 in collaboration with SOX9 and positively regulate histone H3 acetylation at chondrocyte-specific genes. May stimulate early-stage chondrocyte differentiation and inhibit later stage differention (By similarity). Can repress ESR1-mediated transcriptional activation; proposed to act as corepressor for selective nuclear hormone receptors (PubMed:15941852). As an RNA-binding protein, involved in the regulation of inflammatory response by stabilizing selective inflammation-related mRNAs, such as STAT3 and TBX21 (By similarity). Also stabilizes IL6 mRNA (PubMed:32209697). Binds to stem loop structures located in the 3'UTRs of IL6, STAT3 and TBX21 mRNAs; at least for STAT3 prevents binding of ZC3H12A to the mRNA stem loop structure thus inhibiting its degradation activity. Contributes to elevated IL6 levels possibly implicated in autoimmunity processes. IL6-dependent stabilization of STAT3 mRNA may promote differentiation of naive CD4+ T-cells into T-helper Th17 cells. In CD4+ T-cells may also inhibit RORC-induced Th17 cell differentiation independently of IL6 signaling. Stabilization of TBX21 mRNA contributes to elevated interferon-gamma secretion in Th1 cells possibly implicated in the establishment of septic shock (By similarity). Stabilizes TNFRSF4/OX40 mRNA by binding to the conserved stem loop structure in its 3'UTR; thereby competing with the mRNA-destabilizing functions of RC3H1 and endoribonuclease ZC3H12A (By similarity). {ECO:0000250|UniProtKB:Q3U108, ECO:0000269|PubMed:15941852, ECO:0000269|PubMed:32209697, ECO:0000269|PubMed:8649988}. |
| Q04725 | TLE2 | S281 | ochoa | Transducin-like enhancer protein 2 (Enhancer of split groucho-like protein 2) (ESG2) | Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). {ECO:0000250}. |
| Q06418 | TYRO3 | S869 | ochoa | Tyrosine-protein kinase receptor TYRO3 (EC 2.7.10.1) (Tyrosine-protein kinase BYK) (Tyrosine-protein kinase DTK) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine-protein kinase TIF) | Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. {ECO:0000269|PubMed:20546121}.; FUNCTION: (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. {ECO:0000269|PubMed:22156524, ECO:0000269|PubMed:22673088, ECO:0000269|PubMed:25277499}.; FUNCTION: (Microbial infection) Acts as a receptor for Ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. {ECO:0000269|PubMed:17005688}. |
| Q13522 | PPP1R1A | S67 | ochoa|psp | Protein phosphatase 1 regulatory subunit 1A (Protein phosphatase inhibitor 1) (I-1) (IPP-1) | Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases. |
| Q13637 | RAB32 | S154 | ochoa | Ras-related protein Rab-32 (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:11784320, PubMed:21808068). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:11784320). Also acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission (PubMed:12186851). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211). Plays an important role in the control of melanin production and melanosome biogenesis (PubMed:23084991). In concert with RAB38, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity). Stimulates phosphorylation of RAB10 'Thr-73' by LRRK2 (PubMed:38127736). {ECO:0000250|UniProtKB:Q9CZE3, ECO:0000269|PubMed:11784320, ECO:0000269|PubMed:12186851, ECO:0000269|PubMed:21255211, ECO:0000269|PubMed:21808068, ECO:0000269|PubMed:23084991, ECO:0000269|PubMed:38127736}. |
| Q13796 | SHROOM2 | S456 | ochoa | Protein Shroom2 (Apical-like protein) (Protein APXL) | May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). {ECO:0000250}. |
| Q13887 | KLF5 | S153 | psp | Krueppel-like factor 5 (Basic transcription element-binding protein 2) (BTE-binding protein 2) (Colon krueppel-like factor) (GC-box-binding protein 2) (Intestinal-enriched krueppel-like factor) (Transcription factor BTEB2) | Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes. |
| Q14244 | MAP7 | S219 | ochoa | Ensconsin (Epithelial microtubule-associated protein of 115 kDa) (E-MAP-115) (Microtubule-associated protein 7) (MAP-7) | Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments. {ECO:0000269|PubMed:11719555, ECO:0000269|PubMed:8408219, ECO:0000269|PubMed:9989799}. |
| Q14674 | ESPL1 | S1153 | psp | Separin (EC 3.4.22.49) (Caspase-like protein ESPL1) (Extra spindle poles-like 1 protein) (Separase) | Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms. {ECO:0000269|PubMed:10411507, ECO:0000269|PubMed:11509732}. |
| Q14678 | KANK1 | S916 | ochoa | KN motif and ankyrin repeat domain-containing protein 1 (Ankyrin repeat domain-containing protein 15) (Kidney ankyrin repeat-containing protein) | Adapter protein that links structural and signaling protein complexes positioned to guide microtubule and actin cytoskeleton dynamics during cell morphogenesis (PubMed:22084092, PubMed:24120883). At focal adhesions (FAs) rims, organizes cortical microtubule stabilizing complexes (CMSCs) and directly interacts with major FA component TLN1, forming macromolecular assemblies positioned to control microtubule-actin crosstalk at the cell edge (PubMed:24120883, PubMed:27410476). Recruits KIF21A in CMSCs at axonal growth cones and regulates axon guidance by suppressing microtubule growth without inducing microtubule disassembly once it reaches the cell cortex (PubMed:24120883). Interacts with ARFGEF1 and participates in establishing microtubule-organizing center (MTOC) orientation and directed cell movement in wound healing (PubMed:22084092). Regulates actin stress fiber formation and cell migration by inhibiting RHOA activation in response to growth factors; this function involves phosphorylation through PI3K/Akt signaling and may depend on the competitive interaction with 14-3-3 adapter proteins to sequester them from active complexes (PubMed:18458160, PubMed:25961457). Inhibits the formation of lamellipodia but not of filopodia; this function may depend on the competitive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading; this function is partially mediated by BAIAP2 (PubMed:19171758). In the nucleus, is involved in beta-catenin-dependent activation of transcription (PubMed:16968744). During cell division, may regulate DAAM1-dependent RHOA activation that signals centrosome maturation and chromosomal segregation. May also be involved in contractile ring formation during cytokinesis (By similarity). Potential tumor suppressor for renal cell carcinoma (Probable). {ECO:0000250|UniProtKB:E9Q238, ECO:0000269|PubMed:16968744, ECO:0000269|PubMed:18458160, ECO:0000269|PubMed:19171758, ECO:0000269|PubMed:22084092, ECO:0000269|PubMed:24120883, ECO:0000269|PubMed:25961457, ECO:0000269|PubMed:27410476, ECO:0000305|PubMed:12133830}. |
| Q14865 | ARID5B | S1032 | ochoa | AT-rich interactive domain-containing protein 5B (ARID domain-containing protein 5B) (MRF1-like protein) (Modulator recognition factor 2) (MRF-2) | Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-336, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation. Represses the cytomegalovirus enhancer. {ECO:0000269|PubMed:21532585}. |
| Q15031 | LARS2 | S711 | ochoa | Leucine--tRNA ligase, mitochondrial (EC 6.1.1.4) (Leucyl-tRNA synthetase) (LeuRS) | Catalyzes the attachment of leucine to its cognate tRNA. {ECO:0000269|PubMed:26537577}. |
| Q15262 | PTPRK | S856 | ochoa | Receptor-type tyrosine-protein phosphatase kappa (Protein-tyrosine phosphatase kappa) (R-PTP-kappa) (EC 3.1.3.48) | Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa. {ECO:0000269|PubMed:19836242}. |
| Q15349 | RPS6KA2 | S546 | ochoa | Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells. {ECO:0000269|PubMed:16878154, ECO:0000269|PubMed:7623830}. |
| Q15788 | NCOA1 | S863 | psp | Nuclear receptor coactivator 1 (NCoA-1) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 74) (bHLHe74) (Protein Hin-2) (RIP160) (Renal carcinoma antigen NY-REN-52) (Steroid receptor coactivator 1) (SRC-1) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3. {ECO:0000269|PubMed:10449719, ECO:0000269|PubMed:12954634, ECO:0000269|PubMed:7481822, ECO:0000269|PubMed:9223281, ECO:0000269|PubMed:9223431, ECO:0000269|PubMed:9296499, ECO:0000269|PubMed:9427757}. |
| Q16181 | SEPTIN7 | S334 | ochoa | Septin-7 (CDC10 protein homolog) | Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). {ECO:0000269|PubMed:17803907, ECO:0000269|PubMed:18460473, ECO:0000305|PubMed:25588830}. |
| Q16828 | DUSP6 | S197 | psp | Dual specificity protein phosphatase 6 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase PYST1) (Mitogen-activated protein kinase phosphatase 3) (MAP kinase phosphatase 3) (MKP-3) | Dual specificity protein phosphatase, which mediates dephosphorylation and inactivation of MAP kinases (PubMed:8670865). Has a specificity for the ERK family (PubMed:8670865). Plays an important role in alleviating chronic postoperative pain (By similarity). Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity). Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (By similarity). Promotes cell differentiation by regulating MAPK1/MAPK3 activity and regulating the expression of AP1 transcription factors (PubMed:29043977). {ECO:0000250|UniProtKB:Q9DBB1, ECO:0000269|PubMed:29043977, ECO:0000269|PubMed:8670865}. |
| Q2M2Z5 | KIZ | S623 | ochoa | Centrosomal protein kizuna (Polo-like kinase 1 substrate 1) | Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole. {ECO:0000269|PubMed:16980960}. |
| Q58FF6 | HSP90AB4P | S39 | ochoa | Putative heat shock protein HSP 90-beta 4 | Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}. |
| Q58FF7 | HSP90AB3P | S63 | ochoa | Putative heat shock protein HSP 90-beta-3 (Heat shock protein 90-beta c) (Heat shock protein 90Bc) | Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}. |
| Q58FF8 | HSP90AB2P | S63 | ochoa | Putative heat shock protein HSP 90-beta 2 (Heat shock protein 90-beta b) (Heat shock protein 90Bb) | Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}. |
| Q5T0W9 | FAM83B | S514 | ochoa | Protein FAM83B | Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades. {ECO:0000269|PubMed:22886302, ECO:0000269|PubMed:23676467, ECO:0000269|PubMed:23912460}. |
| Q5U651 | RASIP1 | S188 | ochoa | Ras-interacting protein 1 (Rain) | Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells (By similarity). May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS-mediated transformation. Negative regulator of amino acid starvation-induced autophagy. {ECO:0000250, ECO:0000269|PubMed:15031288, ECO:0000269|PubMed:22354037}. |
| Q63HK5 | TSHZ3 | S682 | ochoa | Teashirt homolog 3 (Zinc finger protein 537) | Transcriptional regulator involved in developmental processes. Functions in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s) (PubMed:19343227). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter (By similarity). Involved in the modulation of glutamatergic synaptic transmission and long-term synaptic potentiation (By similarity). {ECO:0000250|UniProtKB:Q8CGV9, ECO:0000269|PubMed:19343227}. |
| Q6IAA8 | LAMTOR1 | S56 | ochoa | Ragulator complex protein LAMTOR1 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1) (Lipid raft adaptor protein p18) (Protein associated with DRMs and endosomes) (p27Kip1-releasing factor from RhoA) (p27RF-Rho) | Key component of the Ragulator complex, a multiprotein complex involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:20381137, PubMed:22980980, PubMed:29158492). Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane (PubMed:22980980, PubMed:28935770, PubMed:29158492, PubMed:30181260, PubMed:31001086, PubMed:32686708, PubMed:36476874). Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (PubMed:20381137, PubMed:22980980, PubMed:29158492). LAMTOR1 is directly responsible for anchoring the Ragulator complex to the lysosomal membrane (PubMed:31001086, PubMed:32686708). LAMTOR1 wraps around the other subunits of the Ragulator complex to hold them in place and interacts with the Rag GTPases, thereby playing a key role in the recruitment of the mTORC1 complex to lysosomes (PubMed:28935770, PubMed:29107538, PubMed:29123114, PubMed:29285400). Also involved in the control of embryonic stem cells differentiation via non-canonical RagC/RRAGC and RagD/RRAGD activation: together with FLCN, it is necessary to recruit and activate RagC/RRAGC and RagD/RRAGD at the lysosomes, and to induce exit of embryonic stem cells from pluripotency via non-canonical, mTOR-independent TFE3 inactivation (By similarity). Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes (PubMed:20381137, PubMed:22980980). May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes (PubMed:20544018). May also play a role in RHOA activation (PubMed:19654316). {ECO:0000250|UniProtKB:Q9CQ22, ECO:0000269|PubMed:19654316, ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:20544018, ECO:0000269|PubMed:22980980, ECO:0000269|PubMed:28935770, ECO:0000269|PubMed:29107538, ECO:0000269|PubMed:29123114, ECO:0000269|PubMed:29158492, ECO:0000269|PubMed:29285400, ECO:0000269|PubMed:30181260, ECO:0000269|PubMed:31001086, ECO:0000269|PubMed:32686708, ECO:0000269|PubMed:36476874}. |
| Q6IQ26 | DENND5A | S455 | ochoa | DENN domain-containing protein 5A (Rab6-interacting protein 1) (Rab6IP1) | Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Involved in the negative regulation of neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:G3V7Q0, ECO:0000269|PubMed:20937701}. |
| Q6NYC8 | PPP1R18 | S175 | ochoa | Phostensin (Protein phosphatase 1 F-actin cytoskeleton-targeting subunit) (Protein phosphatase 1 regulatory subunit 18) | [Isoform 1]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:24434620}.; FUNCTION: [Isoform 4]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:17374523}. |
| Q6P1L5 | FAM117B | S449 | ochoa | Protein FAM117B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 13 protein) | None |
| Q6P996 | PDXDC1 | S572 | ochoa | Pyridoxal-dependent decarboxylase domain-containing protein 1 (EC 4.1.1.-) | None |
| Q6PGN9 | PSRC1 | S140 | ochoa | Proline/serine-rich coiled-coil protein 1 | Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression. {ECO:0000269|PubMed:18411309, ECO:0000269|PubMed:19738423, ECO:0000269|PubMed:26820536}. |
| Q6UUV9 | CRTC1 | S113 | ochoa | CREB-regulated transcription coactivator 1 (Mucoepidermoid carcinoma translocated protein 1) (Transducer of regulated cAMP response element-binding protein 1) (TORC-1) (Transducer of CREB protein 1) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock. {ECO:0000250|UniProtKB:Q157S1, ECO:0000250|UniProtKB:Q68ED7, ECO:0000269|PubMed:23699513}.; FUNCTION: (Microbial infection) Plays a role of coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:16809310}. |
| Q6ZN28 | MACC1 | S201 | ochoa | Metastasis-associated in colon cancer protein 1 (SH3 domain-containing protein 7a5) | Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo. {ECO:0000269|PubMed:19098908}. |
| Q6ZN30 | BNC2 | S904 | ochoa | Zinc finger protein basonuclin-2 | Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes (PubMed:14988505). May also play an important role in early urinary-tract development (PubMed:31051115). {ECO:0000269|PubMed:14988505, ECO:0000269|PubMed:31051115}. |
| Q6ZNC4 | ZNF704 | S97 | ochoa | Zinc finger protein 704 | Transcription factor which binds to RE2 sequence elements in the MYOD1 enhancer. {ECO:0000250|UniProtKB:Q9ERQ3}. |
| Q7RTN6 | STRADA | S313 | ochoa | STE20-related kinase adapter protein alpha (STRAD alpha) (STE20-related adapter protein) (Serologically defined breast cancer antigen NY-BR-96) | Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation. {ECO:0000269|PubMed:12805220, ECO:0000269|PubMed:14517248, ECO:0000269|PubMed:19892943}. |
| Q7RTP6 | MICAL3 | S1310 | ochoa | [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3) | Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. {ECO:0000269|PubMed:21596566, ECO:0000269|PubMed:24440334}. |
| Q7Z401 | DENND4A | S1217 | ochoa | C-myc promoter-binding protein (DENN domain-containing protein 4A) | Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter. {ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:8056341}. |
| Q7Z5J4 | RAI1 | S538 | ochoa | Retinoic acid-induced protein 1 | Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. {ECO:0000269|PubMed:22578325}. |
| Q86V48 | LUZP1 | S248 | ochoa | Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin) | F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250|UniProtKB:Q8R4U7, ECO:0000269|PubMed:30990684, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:38009294, ECO:0000269|PubMed:38832964}. |
| Q86VI3 | IQGAP3 | S539 | ochoa | Ras GTPase-activating-like protein IQGAP3 | None |
| Q86XR7 | TICAM2 | S26 | ochoa | TIR domain-containing adapter molecule 2 (TICAM-2) (Putative NF-kappa-B-activating protein 502) (TRIF-related adapter molecule) (Toll-like receptor adaptor protein 3) (Toll/interleukin-1 receptor domain-containing protein) (MyD88-4) | Functions as a sorting adapter in different signaling pathways to facilitate downstream signaling leading to type I interferon induction (PubMed:16603631, PubMed:16757566, PubMed:25385819, PubMed:25825441). In TLR4 signaling, physically bridges TLR4 and TICAM1 and functionally transmits signal to TICAM1 in early endosomes after endocytosis of TLR4. In TLR2 signaling, physically bridges TLR2 and MYD88 and is required for the TLR2-dependent movement of MYD88 to endosomes following ligand engagement (PubMed:25385819). Involved in IL-18 signaling and is proposed to function as a sorting adapter for MYD88 in IL-18 signaling during adaptive immune response (PubMed:22685567). Forms a complex with RAB11FIP2 that is recruited to the phagosomes to promote the activation of the actin-regulatory GTPases RAC1 and CDC42 and subsequent phagocytosis of Gram-negative bacteria (PubMed:30883606). {ECO:0000269|PubMed:16603631, ECO:0000269|PubMed:16757566, ECO:0000269|PubMed:22685567, ECO:0000269|PubMed:25385819, ECO:0000269|PubMed:25825441, ECO:0000269|PubMed:30883606}.; FUNCTION: [Isoform 2]: Proposed to inhibit LPS-TLR4 signaling at the late endosome by interaction with isoform 1 thereby disrupting the association of isoform 1 with TICAM1. May be involved in TLR4 degradation in late endosomes. |
| Q8IUI8 | CRLF3 | S162 | ochoa | Cytokine receptor-like factor 3 (Cytokine receptor-like molecule 9) (CREME-9) (Cytokine receptor-related protein 4) (Type I cytokine receptor-like factor p48) | May play a role in the negative regulation of cell cycle progression. {ECO:0000269|PubMed:19427400}. |
| Q8IWZ8 | SUGP1 | S326 | ochoa | SURP and G-patch domain-containing protein 1 (RNA-binding protein RBP) (Splicing factor 4) | Plays a role in pre-mRNA splicing. |
| Q8IYD8 | FANCM | S1448 | ochoa | Fanconi anemia group M protein (Protein FACM) (EC 3.6.4.13) (ATP-dependent RNA helicase FANCM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog) | DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (PubMed:16116422). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:16116422, PubMed:19423727, PubMed:20347428, PubMed:20347429, PubMed:29231814). In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (PubMed:20347428, PubMed:20347429). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX (PubMed:20347429). In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates (PubMed:17289582). In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA (PubMed:16116434). {ECO:0000269|PubMed:16116422, ECO:0000269|PubMed:16116434, ECO:0000269|PubMed:17289582, ECO:0000269|PubMed:19423727, ECO:0000269|PubMed:20347428, ECO:0000269|PubMed:20347429, ECO:0000269|PubMed:29231814}. |
| Q8IYH5 | ZZZ3 | S391 | ochoa | ZZ-type zinc finger-containing protein 3 | Histone H3 reader that is required for the ATAC complex-mediated maintenance of histone acetylation and gene activation (PubMed:30217978). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed:19103755). {ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:30217978}. |
| Q8IYH5 | ZZZ3 | S606 | ochoa | ZZ-type zinc finger-containing protein 3 | Histone H3 reader that is required for the ATAC complex-mediated maintenance of histone acetylation and gene activation (PubMed:30217978). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed:19103755). {ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:30217978}. |
| Q8IYM9 | TRIM22 | S87 | ochoa | E3 ubiquitin-protein ligase TRIM22 (EC 2.3.2.27) (50 kDa-stimulated trans-acting factor) (RING finger protein 94) (RING-type E3 ubiquitin transferase TRIM22) (Staf-50) (Tripartite motif-containing protein 22) | Interferon-induced E3 ubiquitin ligase that plays important roles in innate and adaptive immunity (PubMed:25683609, PubMed:35777501). Restricts the replication of many viruses including HIV-1, encephalomyocarditis virus (EMCV), hepatitis B virus (HBV), hepatitis C virus (HCV) or Zika virus (ZIKV) (PubMed:25683609, PubMed:35777501, PubMed:36042495). Mechanistically, negatively regulates HCV replication by promoting ubiquitination and subsequent degradation of viral NS5A (PubMed:25683609). Also acts by promoting the degradation of Zika virus NS1 and NS3 proteins through proteasomal degradation (PubMed:36042495). Acts as a suppressor of basal HIV-1 LTR-driven transcription by preventing Sp1 binding to the HIV-1 promoter (PubMed:26683615). Also plays a role in antiviral immunity by co-regulating together with NT5C2 the RIGI/NF-kappa-B pathway by promoting 'Lys-63'-linked ubiquitination of RIGI, while NT5C2 is responsible for 'Lys-48'-linked ubiquitination of RIGI (PubMed:36159777). Participates in adaptive immunity by suppressing the amount of MHC class II protein in a negative feedback manner in order to limit the extent of MHC class II induction (PubMed:35777501). {ECO:0000269|PubMed:18389079, ECO:0000269|PubMed:18656448, ECO:0000269|PubMed:19218198, ECO:0000269|PubMed:19585648, ECO:0000269|PubMed:25683609, ECO:0000269|PubMed:26683615, ECO:0000269|PubMed:35777501, ECO:0000269|PubMed:36042495, ECO:0000269|PubMed:36159777}. |
| Q8N3K9 | CMYA5 | S767 | ochoa | Cardiomyopathy-associated protein 5 (Dystrobrevin-binding protein 2) (Genethonin-3) (Myospryn) (SPRY domain-containing protein 2) (Tripartite motif-containing protein 76) | May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity). Plays a role in the assembly of ryanodine receptor (RYR2) clusters in striated muscle (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q70KF4}. |
| Q8ND83 | SLAIN1 | S240 | ochoa | SLAIN motif-containing protein 1 | Microtubule plus-end tracking protein that might be involved in the regulation of cytoplasmic microtubule dynamics, microtubule organization and microtubule elongation. {ECO:0000269|PubMed:21646404}. |
| Q8NDT2 | RBM15B | S504 | ochoa | Putative RNA-binding protein 15B (One-twenty two protein 3) (HsOTT3) (HuOTT3) (RNA-binding motif protein 15B) | RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:16129689, PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:27602518). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Functions in the regulation of alternative or illicit splicing, possibly by regulating m6A methylation (PubMed:16129689). Inhibits pre-mRNA splicing (PubMed:21044963). Also functions as a mRNA export factor by acting as a cofactor for the nuclear export receptor NXF1 (PubMed:19586903). {ECO:0000269|PubMed:19586903, ECO:0000269|PubMed:21044963, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:16129689}. |
| Q8NFU7 | TET1 | S322 | ochoa | Methylcytosine dioxygenase TET1 (EC 1.14.11.80) (CXXC-type zinc finger protein 6) (Leukemia-associated protein with a CXXC domain) (Ten-eleven translocation 1 gene protein) | Dioxygenase that plays a key role in active DNA demethylation, by catalyzing the sequential oxidation of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) (PubMed:19372391, PubMed:21496894, PubMed:21778364, PubMed:35798741). In addition to its role in DNA demethylation, plays a more general role in chromatin regulation by recruiting histone modifying protein complexes to alter histone marks and chromatin accessibility, leading to both activation and repression of gene expression (PubMed:33833093). Plays therefore a role in many biological processes, including stem cell maintenance, T- and B-cell development, inflammation regulation, genomic imprinting, neural activity or DNA repair (PubMed:31278917). Involved in the balance between pluripotency and lineage commitment of cells and plays a role in embryonic stem cells maintenance and inner cell mass cell specification. Together with QSER1, plays an essential role in the protection and maintenance of transcriptional and developmental programs to inhibit the binding of DNMT3A/3B and therefore de novo methylation (PubMed:33833093). May play a role in pancreatic beta-cell specification during development. In this context, may function as an upstream epigenetic regulator of PAX4 presumably through direct recruitment by FOXA2 to a PAX4 enhancer to preserve its unmethylated status, thereby potentiating PAX4 expression to adopt beta-cell fate during endocrine lineage commitment (PubMed:35798741). Under DNA hypomethylation conditions, such as in female meiotic germ cells, may induce epigenetic reprogramming of pericentromeric heterochromatin (PCH), the constitutive heterochromatin of pericentromeric regions. PCH forms chromocenters in the interphase nucleus and chromocenters cluster at the prophase of meiosis. In this context, may also be essential for chromocenter clustering in a catalytic activity-independent manner, possibly through the recruitment polycomb repressive complex 1 (PRC1) to the chromocenters (By similarity). During embryonic development, may be required for normal meiotic progression in oocytes and meiotic gene activation (By similarity). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (PubMed:29276034). {ECO:0000250|UniProtKB:Q3URK3, ECO:0000269|PubMed:12124344, ECO:0000269|PubMed:19372391, ECO:0000269|PubMed:19372393, ECO:0000269|PubMed:21496894, ECO:0000269|PubMed:21778364, ECO:0000269|PubMed:25284789, ECO:0000269|PubMed:29276034, ECO:0000269|PubMed:31278917, ECO:0000269|PubMed:33833093, ECO:0000269|PubMed:35798741}.; FUNCTION: [Isoform 1]: Dioxygenase that plays a key role in active DNA demethylation (PubMed:28531272). Binds to promoters, particularly to those with high CG content (By similarity). In hippocampal neurons, isoform 1 regulates the expression of a unique subset of genes compared to isoform 2, although some overlap exists between both isoforms, hence differentially regulates excitatory synaptic transmission (By similarity). In hippocampal neuron cell cultures, isoform 1 controls both miniature excitatory postsynaptic current amplitude and frequency (By similarity). Isoform 1 may regulate genes involved in hippocampal-dependent memory, leading to positive regulation of memory, contrary to isoform 2 that may decrease memory (By similarity). {ECO:0000250|UniProtKB:Q3URK3, ECO:0000269|PubMed:28531272}.; FUNCTION: [Isoform 2]: Dioxygenase that plays a key role in active DNA demethylation (PubMed:28531272). As isoform 1, binds to promoters, particularly to those with high CG content, however displays reduced global chromatin affinity compared with isoform 1, leading to decreased global DNA demethylation compared with isoform 1 (By similarity). Contrary to isoform 1, isoform 2 localizes during S phase to sites of ongoing DNA replication in heterochromatin, causing a significant de novo 5hmC formation, globally, and more so in heterochromatin, including LINE 1 interspersed DNA repeats leading to their activation (By similarity). In hippocampal neurons, isoform 2 regulates the expression of a unique subset of genes compared to isoform 1, although some overlap between both isoforms, hence differentially regulates excitatory synaptic transmission (By similarity). In hippocampal neuron cell cultures, isoform 2 controls miniature excitatory postsynaptic current frequency, but not amplitude (By similarity). Isoform 2 may regulate genes involved in hippocampal-dependent memory, leading to negative regulation of memory, contrary to isoform 1 that may improve memory (By similarity). In immature and partially differentiated gonadotrope cells, directly represses luteinizing hormone gene LHB expression and does not catalyze 5hmC at the gene promoter (By similarity). {ECO:0000250|UniProtKB:Q3URK3, ECO:0000269|PubMed:28531272}. |
| Q8NHU6 | TDRD7 | S319 | ochoa | Tudor domain-containing protein 7 (PCTAIRE2-binding protein) (Tudor repeat associator with PCTAIRE-2) (Trap) | Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis. {ECO:0000269|PubMed:21436445}. |
| Q8NI27 | THOC2 | S407 | ochoa | THO complex subunit 2 (Tho2) (hTREX120) | Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). Required for efficient export of polyadenylated RNA and spliced mRNA (PubMed:23222130). The THOC1-THOC2-THOC3 core complex alone is sufficient to bind export factor NXF1-NXT1 and promote ATPase activity of DDX39B; in the complex THOC2 is the only component that directly interacts with DDX39B (PubMed:33191911). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15833825, PubMed:15998806, PubMed:17190602). Required for NXF1 localization to the nuclear rim (PubMed:22893130). THOC2 (and probably the THO complex) is involved in releasing mRNA from nuclear speckle domains. {ECO:0000269|PubMed:11979277, ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:22893130, ECO:0000269|PubMed:23222130, ECO:0000269|PubMed:33191911}.; FUNCTION: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269|PubMed:18974867}. |
| Q8NI77 | KIF18A | S684 | ochoa | Kinesin-like protein KIF18A (Marrow stromal KIF18A) (MS-KIF18A) | Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression. {ECO:0000269|PubMed:17346968, ECO:0000269|PubMed:18267093, ECO:0000269|PubMed:18513970, ECO:0000269|PubMed:19625775}. |
| Q8TBC5 | ZSCAN18 | S140 | ochoa | Zinc finger and SCAN domain-containing protein 18 (Zinc finger protein 447) | May be involved in transcriptional regulation. |
| Q8TDJ6 | DMXL2 | S1857 | ochoa | DmX-like protein 2 (Rabconnectin-3) | May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles (PubMed:11809763). Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity). {ECO:0000250|UniProtKB:Q8BPN8, ECO:0000269|PubMed:11809763}. |
| Q8TEK3 | DOT1L | S297 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4) | Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones (PubMed:12123582). Binds to DNA (PubMed:12628190). {ECO:0000269|PubMed:12123582, ECO:0000269|PubMed:12628190}. |
| Q8WYL5 | SSH1 | S576 | ochoa | Protein phosphatase Slingshot homolog 1 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 1) (SSH-1L) (hSSH-1L) | Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. {ECO:0000269|PubMed:11832213, ECO:0000269|PubMed:12684437, ECO:0000269|PubMed:12807904, ECO:0000269|PubMed:14531860, ECO:0000269|PubMed:14645219, ECO:0000269|PubMed:15056216, ECO:0000269|PubMed:15159416, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:15671020, ECO:0000269|PubMed:16230460}. |
| Q92729 | PTPRU | S863 | ochoa | Receptor-type tyrosine-protein phosphatase U (R-PTP-U) (EC 3.1.3.48) (Pancreatic carcinoma phosphatase 2) (PCP-2) (Protein-tyrosine phosphatase J) (PTP-J) (hPTP-J) (Protein-tyrosine phosphatase pi) (PTP pi) (Protein-tyrosine phosphatase receptor omicron) (PTP-RO) (Receptor-type protein-tyrosine phosphatase psi) (R-PTP-psi) | Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis. {ECO:0000269|PubMed:10397721, ECO:0000269|PubMed:12501215, ECO:0000269|PubMed:16574648}. |
| Q92733 | PRCC | S212 | ochoa | Proline-rich protein PRCC (Papillary renal cell carcinoma translocation-associated gene protein) | May regulate cell cycle progression through interaction with MAD2L2. {ECO:0000269|PubMed:11717438}. |
| Q92796 | DLG3 | S493 | ochoa | Disks large homolog 3 (Neuroendocrine-DLG) (Synapse-associated protein 102) (SAP-102) (SAP102) (XLMR) | Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling. |
| Q92797 | SYMPK | S938 | ochoa | Symplekin | Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity. {ECO:0000269|PubMed:16230528, ECO:0000269|PubMed:20861839}. |
| Q92835 | INPP5D | S27 | psp | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (EC 3.1.3.86) (Inositol polyphosphate-5-phosphatase D) (EC 3.1.3.56) (Inositol polyphosphate-5-phosphatase of 145 kDa) (SIP-145) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (SH2 domain-containing inositol 5'-phosphatase 1) (SH2 domain-containing inositol phosphatase 1) (SHIP-1) (p150Ship) (hp51CN) | Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:10764818, PubMed:8723348, PubMed:8769125). Able also to hydrolyzes the 5-phosphate of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P3) and inositol 1,3,4,5-tetrakisphosphate (PubMed:10764818, PubMed:8769125, PubMed:9108392). Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity (PubMed:16682172). Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. {ECO:0000269|PubMed:10764818, ECO:0000269|PubMed:12421919, ECO:0000269|PubMed:16682172, ECO:0000269|PubMed:8723348, ECO:0000269|PubMed:8769125, ECO:0000269|PubMed:9108392}. |
| Q93075 | TATDN2 | S115 | ochoa | 3'-5' RNA nuclease TATDN2 (EC 3.1.13.-) (TatD DNase domain containing 2) | Mg(2+)-dependent 3'RNA exonuclease and endonuclease that resolves R-loops via specific degradation of R-loop RNA stucture (PubMed:37953292). Shows no activity against D-loop and minimal activity against the RNA strand of an RNA-DNA hybrid duplex oligomer. Has no 3' or 5' exonuclease activity, no uracil glycosylase activity, and no 5' flap endonuclease activity on DNA substrates (PubMed:37953292). May have a role in maintaining genomic stability through its role in R-loop resolution (PubMed:37953292). {ECO:0000269|PubMed:37953292}. |
| Q96C34 | RUNDC1 | S290 | ochoa | RUN domain-containing protein 1 | May play a role as p53/TP53 inhibitor and thus may have oncogenic activity. {ECO:0000269|PubMed:16929179}. |
| Q96CN9 | GCC1 | S416 | ochoa | GRIP and coiled-coil domain-containing protein 1 (Golgi coiled-coil protein 1) | Probably involved in maintaining Golgi structure. |
| Q96D70 | R3HDM4 | S36 | ochoa | R3H domain-containing protein 4 | None |
| Q96HB5 | CCDC120 | S498 | ochoa | Coiled-coil domain-containing protein 120 | Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells (PubMed:28422092). Together with CCDC68, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly (PubMed:28422092). Recruits NIN and CEP170 to centrosomes (PubMed:28422092). Also required for neurite growth. Localizes CYTH2 to vesicles to allow its transport along neurites, and subsequent ARF6 activation and neurite growth. {ECO:0000269|PubMed:25326380}. |
| Q96S94 | CCNL2 | S348 | ochoa | Cyclin-L2 (Paneth cell-enhanced expression protein) | Involved in pre-mRNA splicing. May induce cell death, possibly by acting on the transcription and RNA processing of apoptosis-related factors. {ECO:0000269|PubMed:14684736, ECO:0000269|PubMed:18216018}. |
| Q99459 | CDC5L | S293 | ochoa | Cell division cycle 5-like protein (Cdc5-like protein) (Pombe cdc5-related protein) | DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:11991638, PubMed:20176811, PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30705154, PubMed:30728453). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR) (PubMed:20176811). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:10570151, ECO:0000269|PubMed:11082045, ECO:0000269|PubMed:11101529, ECO:0000269|PubMed:11544257, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12927788, ECO:0000269|PubMed:18583928, ECO:0000269|PubMed:20176811, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:30728453, ECO:0000269|PubMed:9038199, ECO:0000269|PubMed:9468527, ECO:0000269|PubMed:9632794, ECO:0000305|PubMed:33509932}. |
| Q9BRR8 | GPATCH1 | S715 | ochoa | G patch domain-containing protein 1 (Evolutionarily conserved G-patch domain-containing protein) | None |
| Q9BTC8 | MTA3 | S519 | ochoa | Metastasis-associated protein MTA3 | Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:12705869, PubMed:16428440, PubMed:28977666). Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels (PubMed:12705869). Contributes to transcriptional repression by BCL6 (PubMed:15454082). {ECO:0000269|PubMed:12705869, ECO:0000269|PubMed:15454082, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}. |
| Q9BX66 | SORBS1 | S1051 | ochoa | Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) | Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250|UniProtKB:Q62417}. |
| Q9BX79 | STRA6 | S404 | ochoa | Receptor for retinol uptake STRA6 (Retinol-binding protein receptor STRA6) (Stimulated by retinoic acid gene 6 protein homolog) | Functions as a retinol transporter. Accepts all-trans retinol from the extracellular retinol-binding protein RBP4, facilitates retinol transport across the cell membrane, and then transfers retinol to the cytoplasmic retinol-binding protein RBP1 (PubMed:18316031, PubMed:22665496, PubMed:9452451). Retinol uptake is enhanced by LRAT, an enzyme that converts retinol to all-trans retinyl esters, the storage forms of vitamin A (PubMed:18316031, PubMed:22665496). Contributes to the activation of a signaling cascade that depends on retinol transport and LRAT-dependent generation of retinol metabolites that then trigger activation of JAK2 and its target STAT5, and ultimately increase the expression of SOCS3 and inhibit cellular responses to insulin (PubMed:21368206, PubMed:22665496). Important for the homeostasis of vitamin A and its derivatives, such as retinoic acid (PubMed:18316031). STRA6-mediated transport is particularly important in the eye, and under conditions of dietary vitamin A deficiency (Probable). Does not transport retinoic acid (PubMed:18316031). {ECO:0000269|PubMed:18316031, ECO:0000269|PubMed:21901792, ECO:0000269|PubMed:22665496, ECO:0000269|PubMed:9452451, ECO:0000305}. |
| Q9BYW2 | SETD2 | S708 | ochoa | Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) | Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}. |
| Q9BZC7 | ABCA2 | S2381 | ochoa | ATP-binding cassette sub-family A member 2 (EC 7.6.2.-) (ATP-binding cassette transporter 2) (ATP-binding cassette 2) | Probable lipid transporter that modulates cholesterol sequestration in the late endosome/lysosome by regulating the intracellular sphingolipid metabolism, in turn participates in cholesterol homeostasis (Probable) (PubMed:15238223, PubMed:21810484, PubMed:24201375). May alter the transbilayer distribution of ceramide in the intraluminal membrane lipid bilayer, favoring its retention in the outer leaflet that results in increased acid ceramidase activity in the late endosome/lysosome, facilitating ceramide deacylation to sphingosine leading to the sequestration of free cholesterol in lysosomes (PubMed:24201375). In addition regulates amyloid-beta production either by activating a signaling pathway that regulates amyloid precursor protein transcription through the modulation of sphingolipid metabolism or through its role in gamma-secretase processing of APP (PubMed:22086926, PubMed:26510981). May play a role in myelin formation (By similarity). {ECO:0000250|UniProtKB:P41234, ECO:0000269|PubMed:15238223, ECO:0000269|PubMed:21810484, ECO:0000269|PubMed:22086926, ECO:0000269|PubMed:24201375, ECO:0000269|PubMed:26510981, ECO:0000305|PubMed:15999530}. |
| Q9C0D2 | CEP295 | S1102 | ochoa | Centrosomal protein of 295 kDa | Centriole-enriched microtubule-binding protein involved in centriole biogenesis (PubMed:20844083, PubMed:25131205, PubMed:27185865, PubMed:38154379). Essential for the generation of the distal portion of new-born centrioles in a CPAP- and CEP120-mediated elongation dependent manner during the cell cycle S/G2 phase after formation of the initiating cartwheel structure (PubMed:27185865). Required for the recruitment of centriolar proteins, such as POC1B, POC5 and CEP135, into the distal portion of centrioles (PubMed:27185865). Also required for centriole-to-centrosome conversion during mitotic progression, but is dispensable for cartwheel removal or centriole disengagement (PubMed:25131205). Binds to and stabilizes centriolar microtubule (PubMed:27185865). May be involved in ciliogenesis (PubMed:38154379). {ECO:0000269|PubMed:20844083, ECO:0000269|PubMed:25131205, ECO:0000269|PubMed:27185865, ECO:0000269|PubMed:32060285, ECO:0000269|PubMed:38154379}. |
| Q9GZR7 | DDX24 | S60 | ochoa | ATP-dependent RNA helicase DDX24 (EC 3.6.4.13) (DEAD box protein 24) | ATP-dependent RNA helicase that plays a role in various aspects of RNA metabolism including pre-mRNA splicing and is thereby involved in different biological processes such as cell cycle regulation or innate immunity (PubMed:24204270, PubMed:24980433). Plays an inhibitory role in TP53 transcriptional activity and subsequently in TP53 controlled cell growth arrest and senescence by inhibiting its EP300 mediated acetylation (PubMed:25867071). Negatively regulates cytosolic RNA-mediated innate immune signaling at least in part by affecting RIPK1/IRF7 interactions. Alternatively, possesses antiviral activity by recognizing gammaherpesvirus transcripts in the context of lytic reactivation (PubMed:36298642). Plays an essential role in cell cycle regulation in vascular smooth muscle cells by interacting with and regulating FANCA (Fanconi anemia complementation group A) mRNA (By similarity). {ECO:0000250|UniProtKB:Q9ESV0, ECO:0000269|PubMed:24204270, ECO:0000269|PubMed:24980433, ECO:0000269|PubMed:25867071, ECO:0000269|PubMed:36298642}.; FUNCTION: (Microbial infection) Plays a positive role in HIV-1 infection by promoting Rev-dependent nuclear export of viral RNAs and their packaging into virus particles (PubMed:24204270). {ECO:0000269|PubMed:18289627, ECO:0000269|PubMed:24204270}. |
| Q9H257 | CARD9 | S431 | ochoa | Caspase recruitment domain-containing protein 9 (hCARD9) | Adapter protein that plays a key role in innate immune response against fungi by forming signaling complexes downstream of C-type lectin receptors (PubMed:26961233, PubMed:33558980). CARD9-mediated signals are essential for antifungal immunity against a subset of fungi from the phylum Ascomycota (PubMed:24231284, PubMed:25057046, PubMed:25702837, PubMed:26521038, PubMed:26679537, PubMed:26961233, PubMed:27777981, PubMed:29080677, PubMed:33558980). Transduces signals in myeloid cells downstream of C-type lectin receptors CLEC7A (dectin-1), CLEC6A (dectin-2) and CLEC4E (Mincle), which detect pathogen-associated molecular pattern metabolites (PAMPs), such as fungal carbohydrates, and trigger CARD9 activation (By similarity). Upon activation, CARD9 homooligomerizes to form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10 and subsequent recruitment of MALT1: this leads to activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:11053425, PubMed:26488816, PubMed:26961233, PubMed:31296852, PubMed:33558980). CARD9 signaling in antigen-presenting cells links innate sensing of fungi to the activation of adaptive immunity and provides a cytokine milieu that induces the development and subsequent of interleukin 17-producing T helper (Th17) cells (PubMed:24231284). Also involved in activation of myeloid cells via classical ITAM-associated receptors and TLR: required for TLR-mediated activation of MAPK, while it is not required for TLR-induced activation of NF-kappa-B (By similarity). CARD9 can also be engaged independently of BCL10: forms a complex with RASGRF1 downstream of C-type lectin receptors, which recruits and activates HRAS, leading to ERK activation and the production of cytokines (By similarity). Acts as an important regulator of the intestinal commensal fungi (mycobiota) component of the gut microbiota (PubMed:33548172). Plays an essential role in antifungal immunity against dissemination of gut fungi: acts by promoting induction of antifungal IgG antibodies response in CX3CR1(+) macrophages to confer protection against disseminated C.albicans or C.auris infection (PubMed:33548172). Also mediates immunity against other pathogens, such as certain bacteria, viruses and parasites; CARD9 signaling is however redundant with other innate immune responses (By similarity). In response to L.monocytogenes infection, required for the production of inflammatory cytokines activated by intracellular peptidoglycan: acts by connecting NOD2 recognition of peptidoglycan to downstream activation of MAP kinases (MAPK) without activating NF-kappa-B (By similarity). {ECO:0000250|UniProtKB:A2AIV8, ECO:0000269|PubMed:11053425, ECO:0000269|PubMed:24231284, ECO:0000269|PubMed:25057046, ECO:0000269|PubMed:25702837, ECO:0000269|PubMed:26488816, ECO:0000269|PubMed:26521038, ECO:0000269|PubMed:26679537, ECO:0000269|PubMed:26961233, ECO:0000269|PubMed:27777981, ECO:0000269|PubMed:29080677, ECO:0000269|PubMed:31296852, ECO:0000269|PubMed:33548172, ECO:0000269|PubMed:33558980}. |
| Q9H6K5 | PRR36 | S1310 | ochoa | Proline-rich protein 36 | None |
| Q9H6S1 | AZI2 | S301 | ochoa | 5-azacytidine-induced protein 2 (NF-kappa-B-activating kinase-associated protein 1) (Nak-associated protein 1) (Nap1) (TILP) | Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity (PubMed:14560022, PubMed:21931631). Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization (PubMed:14560022, PubMed:21931631). Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1 (PubMed:14560022, PubMed:21931631). Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B (PubMed:14560022, PubMed:21931631). Participates in IFNB promoter activation via TICAM1 (PubMed:15611223). {ECO:0000269|PubMed:14560022, ECO:0000269|PubMed:15611223, ECO:0000269|PubMed:21931631}. |
| Q9H7D0 | DOCK5 | S365 | ochoa | Dedicator of cytokinesis protein 5 | Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP (By similarity). Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829). {ECO:0000250|UniProtKB:B2RY04, ECO:0000269|PubMed:19004829}. |
| Q9H910 | JPT2 | S97 | ochoa|psp | Jupiter microtubule associated homolog 2 (Hematological and neurological expressed 1-like protein) (HN1-like protein) | Nicotinic acid adenine dinucleotide phosphate (NAADP) binding protein required for NAADP-evoked intracellular calcium release (PubMed:33758061, PubMed:33758062). Confers NAADP-sensitivity to the two pore channels (TPCs) complex (PubMed:33758061). Enables NAADP to activate Ca(2+) release from the endoplasmic reticulum through ryanodine receptors (PubMed:33758062). {ECO:0000269|PubMed:33758061, ECO:0000269|PubMed:33758062}.; FUNCTION: (Microbial infection) Involved in the endolysosomal trafficking of human coronavirus SARS-CoV-2. {ECO:0000269|PubMed:33758061}. |
| Q9HCY8 | S100A14 | S77 | ochoa | Protein S100-A14 (S100 calcium-binding protein A14) (S114) | Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium. {ECO:0000269|PubMed:21559403, ECO:0000269|PubMed:22032898, ECO:0000269|PubMed:22451655}. |
| Q9NP58 | ABCB6 | S755 | ochoa | ATP-binding cassette sub-family B member 6 (ABC-type heme transporter ABCB6) (EC 7.6.2.5) (Mitochondrial ABC transporter 3) (Mt-ABC transporter 3) (P-glycoprotein-related protein) (Ubiquitously-expressed mammalian ABC half transporter) | ATP-dependent transporter that catalyzes the transport of a broad-spectrum of porphyrins from the cytoplasm to the extracellular space through the plasma membrane or into the vesicle lumen (PubMed:17661442, PubMed:23792964, PubMed:27507172, PubMed:33007128). May also function as an ATP-dependent importer of porphyrins from the cytoplasm into the mitochondria, in turn may participate in the de novo heme biosynthesis regulation and in the coordination of heme and iron homeostasis during phenylhydrazine stress (PubMed:10837493, PubMed:17006453, PubMed:23792964, PubMed:33007128). May also play a key role in the early steps of melanogenesis producing PMEL amyloid fibrils (PubMed:29940187). In vitro, it confers to cells a resistance to toxic metal such as arsenic and cadmium and against chemotherapeutics agent such as 5-fluorouracil, SN-38 and vincristin (PubMed:21266531, PubMed:25202056, PubMed:31053883). In addition may play a role in the transition metal homeostasis (By similarity). {ECO:0000250|UniProtKB:O70595, ECO:0000269|PubMed:10837493, ECO:0000269|PubMed:17006453, ECO:0000269|PubMed:17661442, ECO:0000269|PubMed:21266531, ECO:0000269|PubMed:23792964, ECO:0000269|PubMed:25202056, ECO:0000269|PubMed:27507172, ECO:0000269|PubMed:29940187, ECO:0000269|PubMed:31053883, ECO:0000269|PubMed:33007128}. |
| Q9NQC7 | CYLD | S436 | psp | Ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.4.19.12) (Deubiquitinating enzyme CYLD) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD) | Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-alpha-induced necroptosis (PubMed:18313383, PubMed:18636086, PubMed:26670046, PubMed:26997266, PubMed:27458237, PubMed:27591049, PubMed:27746020, PubMed:29291351, PubMed:32185393). Negatively regulates NF-kappa-B activation by deubiquitinating upstream signaling factors (PubMed:12917689, PubMed:12917691, PubMed:32185393). Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation (PubMed:12917690). Negative regulator of Wnt signaling (PubMed:20227366). Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules (PubMed:19893491). Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis (PubMed:18222923, PubMed:20194890). Required for normal cell cycle progress and normal cytokinesis (PubMed:17495026, PubMed:19893491). Inhibits nuclear translocation of NF-kappa-B (PubMed:18636086). Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation (PubMed:18636086). Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells (By similarity). Negatively regulates TNFRSF11A signaling and osteoclastogenesis (By similarity). Involved in the regulation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane; this process does not depend on NF-kappa-B activation (By similarity). Ability to remove linear ('Met-1'-linked) polyubiquitin chains regulates innate immunity and TNF-alpha-induced necroptosis: recruited to the LUBAC complex via interaction with SPATA2 and restricts linear polyubiquitin formation on target proteins (PubMed:26670046, PubMed:26997266, PubMed:27458237, PubMed:27591049). Regulates innate immunity by restricting linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation (PubMed:26997266). Involved in TNF-alpha-induced necroptosis by removing linear ('Met-1'-linked) polyubiquitin chains from RIPK1, thereby regulating the kinase activity of RIPK1 (By similarity). Negatively regulates intestinal inflammation by removing 'Lys-63' linked polyubiquitin chain of NLRP6, thereby reducing the interaction between NLRP6 and PYCARD/ASC and formation of the NLRP6 inflammasome (By similarity). Does not catalyze deubiquitination of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains (PubMed:27746020). Removes 'Lys-63' linked polyubiquitin chain of MAP3K7, which inhibits phosphorylation and blocks downstream activation of the JNK-p38 kinase cascades (PubMed:29291351). Also removes 'Lys-63'-linked polyubiquitin chains of MAP3K1 and MA3P3K3, which inhibit their interaction with MAP2K1 and MAP2K2 (PubMed:34497368). {ECO:0000250|UniProtKB:Q80TQ2, ECO:0000269|PubMed:12917689, ECO:0000269|PubMed:12917690, ECO:0000269|PubMed:12917691, ECO:0000269|PubMed:17495026, ECO:0000269|PubMed:18222923, ECO:0000269|PubMed:18313383, ECO:0000269|PubMed:18636086, ECO:0000269|PubMed:19893491, ECO:0000269|PubMed:20194890, ECO:0000269|PubMed:20227366, ECO:0000269|PubMed:26670046, ECO:0000269|PubMed:26997266, ECO:0000269|PubMed:27458237, ECO:0000269|PubMed:27591049, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:29291351, ECO:0000269|PubMed:32185393, ECO:0000269|PubMed:34497368}. |
| Q9NR09 | BIRC6 | S2221 | ochoa | Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 (EC 2.3.2.24) (BIR repeat-containing ubiquitin-conjugating enzyme) (BRUCE) (Baculoviral IAP repeat-containing protein 6) (Ubiquitin-conjugating BIR domain enzyme apollon) (APOLLON) | Anti-apoptotic protein known as inhibitor of apoptosis (IAP) which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase (PubMed:14765125, PubMed:15200957, PubMed:18329369). Unlike most IAPs, does not contain a RING domain and it is not a RING-type E3 ligase (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Instead acts as a dual E2/E3 enzyme that combines ubiquitin conjugating (E2) and ubiquitin ligase (E3) activities in a single polypeptide (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitination is mediated by a non-canonical E1 ubiquitin activating enzyme UBA6 (PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates CASP3, CASP7 and CASP9 and inhibits their caspase activity; also ubiquitinates their procaspases but to a weaker extent (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates pro-apoptotic factors DIABLO/SMAC and HTRA2 (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). DIABLO/SMAC antagonizes the caspase inhibition activity of BIRC6 by competing for the same binding sites as the caspases (PubMed:18329369, PubMed:36758106). Ubiquitinates the autophagy protein MAP1LC3B; this activity is also inhibited by DIABLO/SMAC (PubMed:36758105). Important regulator for the final stages of cytokinesis (PubMed:18329369). Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification (PubMed:18329369). {ECO:0000269|PubMed:14765125, ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:18329369, ECO:0000269|PubMed:36758104, ECO:0000269|PubMed:36758105, ECO:0000269|PubMed:36758106}. |
| Q9NR09 | BIRC6 | S3590 | ochoa | Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 (EC 2.3.2.24) (BIR repeat-containing ubiquitin-conjugating enzyme) (BRUCE) (Baculoviral IAP repeat-containing protein 6) (Ubiquitin-conjugating BIR domain enzyme apollon) (APOLLON) | Anti-apoptotic protein known as inhibitor of apoptosis (IAP) which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase (PubMed:14765125, PubMed:15200957, PubMed:18329369). Unlike most IAPs, does not contain a RING domain and it is not a RING-type E3 ligase (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Instead acts as a dual E2/E3 enzyme that combines ubiquitin conjugating (E2) and ubiquitin ligase (E3) activities in a single polypeptide (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitination is mediated by a non-canonical E1 ubiquitin activating enzyme UBA6 (PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates CASP3, CASP7 and CASP9 and inhibits their caspase activity; also ubiquitinates their procaspases but to a weaker extent (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates pro-apoptotic factors DIABLO/SMAC and HTRA2 (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). DIABLO/SMAC antagonizes the caspase inhibition activity of BIRC6 by competing for the same binding sites as the caspases (PubMed:18329369, PubMed:36758106). Ubiquitinates the autophagy protein MAP1LC3B; this activity is also inhibited by DIABLO/SMAC (PubMed:36758105). Important regulator for the final stages of cytokinesis (PubMed:18329369). Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification (PubMed:18329369). {ECO:0000269|PubMed:14765125, ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:18329369, ECO:0000269|PubMed:36758104, ECO:0000269|PubMed:36758105, ECO:0000269|PubMed:36758106}. |
| Q9NRH3 | TUBG2 | S80 | ochoa|psp | Tubulin gamma-2 chain (Gamma-2-tubulin) | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685). Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:38305685). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685). {ECO:0000269|PubMed:38305685}. |
| Q9NUU7 | DDX19A | S85 | ochoa | ATP-dependent RNA helicase DDX19A (EC 3.6.4.13) (DDX19-like protein) (DEAD box protein 19A) | ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19 functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins. {ECO:0000250|UniProtKB:Q9UMR2}. |
| Q9NV70 | EXOC1 | T568 | ochoa | Exocyst complex component 1 (Exocyst complex component Sec3) | Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.; FUNCTION: (Microbial infection) Has an antiviral effect against flaviviruses by affecting viral RNA transcription and translation through the sequestration of elongation factor 1-alpha (EEF1A1). This results in decreased viral RNA synthesis and decreased viral protein translation. {ECO:0000269|PubMed:19889084}. |
| Q9P0B6 | CCDC167 | S42 | ochoa | Coiled-coil domain-containing protein 167 | None |
| Q9P225 | DNAH2 | S334 | ochoa | Dynein axonemal heavy chain 2 (Axonemal beta dynein heavy chain 2) (Ciliary dynein heavy chain 2) (Dynein heavy chain domain-containing protein 3) | As part of the axonemal inner dynein arm complex plays a central role in ciliary beat (PubMed:30811583). Expressed in sperm flagellum, it is required for sperm motility (PubMed:30811583). Dyneins are microtubule-based molecular motors possessing ATPase activities that can convert the chemical energy of ATP into relative sliding between adjacent microtubule doublets to generate ciliary bending (PubMed:30811583). {ECO:0000269|PubMed:30811583}. |
| Q9P2B7 | CFAP97 | S474 | ochoa | Cilia- and flagella-associated protein 97 | None |
| Q9P2F8 | SIPA1L2 | S379 | ochoa | Signal-induced proliferation-associated 1-like protein 2 (SIPA1-like protein 2) | None |
| Q9UBK2 | PPARGC1A | S273 | ochoa | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1-alpha) (PPAR-gamma coactivator 1-alpha) (PPARGC-1-alpha) (Ligand effect modulator 6) | Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:10713165, PubMed:20005308, PubMed:21376232, PubMed:28363985, PubMed:32433991). Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter (PubMed:10713165, PubMed:20005308, PubMed:21376232). Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis (PubMed:10713165, PubMed:20005308, PubMed:21376232). Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism (PubMed:10713165, PubMed:20005308, PubMed:21376232). Acts as a key regulator of gluconeogenesis: stimulates hepatic gluconeogenesis by increasing the expression of gluconeogenic enzymes, and acting together with FOXO1 to promote the fasting gluconeogenic program (PubMed:16753578, PubMed:23142079). Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner (PubMed:23836911). Also involved in the integration of the circadian rhythms and energy metabolism (By similarity). Required for oscillatory expression of clock genes, such as BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK (By similarity). {ECO:0000250|UniProtKB:O70343, ECO:0000269|PubMed:10713165, ECO:0000269|PubMed:16753578, ECO:0000269|PubMed:20005308, ECO:0000269|PubMed:21376232, ECO:0000269|PubMed:23142079, ECO:0000269|PubMed:23836911, ECO:0000269|PubMed:28363985, ECO:0000269|PubMed:32433991}. |
| Q9UHF7 | TRPS1 | S978 | ochoa | Zinc finger transcription factor Trps1 (Tricho-rhino-phalangeal syndrome type I protein) (Zinc finger protein GC79) | Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes. {ECO:0000269|PubMed:12885770, ECO:0000269|PubMed:17391059}. |
| Q9UIF8 | BAZ2B | S1541 | ochoa | Bromodomain adjacent to zinc finger domain protein 2B (hWALp4) | Regulatory subunit of the ATP-dependent BRF-1 and BRF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The BRF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the BRF-5 ISWI chromatin remodeling complex (PubMed:28801535). Chromatin reader protein, which may play a role in transcriptional regulation via interaction with ISWI (By similarity) (PubMed:10662543). Involved in positively modulating the rate of age-related behavioral deterioration (By similarity). Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with histone methyltransferase EHMT1 (By similarity). {ECO:0000250|UniProtKB:A2AUY4, ECO:0000269|PubMed:28801535, ECO:0000303|PubMed:10662543}. |
| Q9UIG0 | BAZ1B | S349 | ochoa | Tyrosine-protein kinase BAZ1B (EC 2.7.10.2) (Bromodomain adjacent to zinc finger domain protein 1B) (Williams syndrome transcription factor) (Williams-Beuren syndrome chromosomal region 10 protein) (Williams-Beuren syndrome chromosomal region 9 protein) (hWALp2) | Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator (PubMed:19092802). Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph) (PubMed:19092802, PubMed:19234442). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19092802, PubMed:19234442). Regulatory subunit of the ATP-dependent WICH-1 and WICH-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:11980720, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The WICH-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the WICH-5 ISWI chromatin remodeling complex (PubMed:28801535). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the recruitment of the WICH-5 ISWI chromatin remodeling complex to replication foci during DNA replication (PubMed:15543136). {ECO:0000250|UniProtKB:Q9Z277, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:19092802, ECO:0000269|PubMed:19234442, ECO:0000269|PubMed:28801535}. |
| Q9UJ14 | GGT7 | S83 | ochoa | Glutathione hydrolase 7 (EC 3.4.19.13) (Gamma-glutamyltransferase 7) (GGT 7) (EC 2.3.2.2) (Gamma-glutamyltransferase-like 3) (Gamma-glutamyltransferase-like 5) (Gamma-glutamyltranspeptidase 7) [Cleaved into: Glutathione hydrolase 7 heavy chain; Glutathione hydrolase 7 light chain] | Hydrolyzes and transfers gamma-glutamyl moieties from glutathione and other gamma-glutamyl compounds to acceptors. {ECO:0000250|UniProtKB:P19440}. |
| Q9UKA9 | PTBP2 | S434 | ochoa | Polypyrimidine tract-binding protein 2 (Neural polypyrimidine tract-binding protein) (Neurally-enriched homolog of PTB) (PTB-like protein) | RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. In addition to its function in pre-mRNA splicing, plays also a role in the regulation of translation. {ECO:0000250|UniProtKB:Q91Z31, ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:12667457}.; FUNCTION: [Isoform 5]: Reduced affinity for RNA. {ECO:0000269|PubMed:12213192}. |
| Q9UMR2 | DDX19B | S86 | ochoa | ATP-dependent RNA helicase DDX19B (EC 3.6.4.13) (DEAD box RNA helicase DEAD5) (DEAD box protein 19B) | ATP-dependent RNA helicase involved in mRNA export from the nucleus (PubMed:10428971). Rather than unwinding RNA duplexes, DDX19B functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins (PubMed:10428971). {ECO:0000269|PubMed:10428971}. |
| Q9UNA4 | POLI | S502 | ochoa | DNA polymerase iota (EC 2.7.7.7) (Eta2) (RAD30 homolog B) | Error-prone DNA polymerase specifically involved in DNA repair (PubMed:11013228, PubMed:11387224). Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls (PubMed:11013228, PubMed:11387224, PubMed:14630940, PubMed:15199127). Favors Hoogsteen base-pairing in the active site (PubMed:15254543). Inserts the correct base with high-fidelity opposite an adenosine template (PubMed:15254543). Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine (PubMed:11013228). May play a role in hypermutation of immunoglobulin genes (PubMed:12410315). Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity (PubMed:11251121, PubMed:14630940). {ECO:0000269|PubMed:11013228, ECO:0000269|PubMed:11251121, ECO:0000269|PubMed:11387224, ECO:0000269|PubMed:12410315, ECO:0000269|PubMed:14630940, ECO:0000269|PubMed:15199127, ECO:0000269|PubMed:15254543}. |
| Q9Y285 | FARSA | S490 | ochoa | Phenylalanine--tRNA ligase alpha subunit (EC 6.1.1.20) (CML33) (Phenylalanyl-tRNA synthetase alpha subunit) (PheRS) | None |
| Q9Y485 | DMXL1 | S1830 | ochoa | DmX-like protein 1 (X-like 1 protein) | None |
| Q9Y4B5 | MTCL1 | S1588 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y4F9 | RIPOR2 | S730 | ochoa | Rho family-interacting cell polarization regulator 2 | Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization (PubMed:17150207, PubMed:23241886, PubMed:24687993, PubMed:24958875, PubMed:25588844, PubMed:27556504). Inhibits chemokine-induced T lymphocyte responses, such as cell adhesion, polarization and migration (PubMed:23241886). Involved also in the regulation of neutrophil polarization, chemotaxis and adhesion (By similarity). Required for normal development of inner and outer hair cell stereocilia within the cochlea of the inner ear (By similarity). Plays a role for maintaining the structural organization of the basal domain of stereocilia (By similarity). Involved in mechanosensory hair cell function (By similarity). Required for normal hearing (PubMed:24958875). {ECO:0000250|UniProtKB:Q80U16, ECO:0000269|PubMed:17150207, ECO:0000269|PubMed:23241886, ECO:0000269|PubMed:24687993, ECO:0000269|PubMed:24958875, ECO:0000269|PubMed:27556504}.; FUNCTION: [Isoform 2]: Acts as an inhibitor of the small GTPase RHOA (PubMed:25588844). Plays a role in fetal mononuclear myoblast differentiation by promoting filopodia and myotube formation (PubMed:17150207). Maintains naive T lymphocytes in a quiescent state (PubMed:27556504). {ECO:0000269|PubMed:17150207, ECO:0000269|PubMed:25588844, ECO:0000269|PubMed:27556504}. |
| Q9Y6Q5 | AP1M2 | S63 | ochoa | AP-1 complex subunit mu-2 (AP-mu chain family member mu1B) (Adaptor protein complex AP-1 subunit mu-2) (Adaptor-related protein complex 1 subunit mu-2) (Clathrin assembly protein complex 1 mu-2 medium chain 2) (Golgi adaptor HA1/AP1 adaptin mu-2 subunit) (Mu-adaptin 2) (Mu1B-adaptin) | Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. |
| O14744 | PRMT5 | S470 | Sugiyama | Protein arginine N-methyltransferase 5 (PRMT5) (EC 2.1.1.320) (72 kDa ICln-binding protein) (Histone-arginine N-methyltransferase PRMT5) (Jak-binding protein 1) (Shk1 kinase-binding protein 1 homolog) (SKB1 homolog) (SKB1Hs) [Cleaved into: Protein arginine N-methyltransferase 5, N-terminally processed] | Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA (PubMed:10531356, PubMed:11152681, PubMed:11747828, PubMed:12411503, PubMed:15737618, PubMed:17709427, PubMed:20159986, PubMed:20810653, PubMed:21081503, PubMed:21258366, PubMed:21917714, PubMed:22269951). Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles (PubMed:11747828, PubMed:12411503, PubMed:17709427). Methylates SUPT5H and may regulate its transcriptional elongation properties (PubMed:12718890). May methylate the N-terminal region of MBD2 (PubMed:16428440). Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. Methylates histone H2A and H4 'Arg-3' during germ cell development (By similarity). Methylates histone H3 'Arg-8', which may repress transcription (By similarity). Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (By similarity). Methylates RPS10. Attenuates EGF signaling through the MAPK1/MAPK3 pathway acting at 2 levels. First, monomethylates EGFR; this enhances EGFR 'Tyr-1197' phosphorylation and PTPN6 recruitment, eventually leading to reduced SOS1 phosphorylation (PubMed:21258366, PubMed:21917714). Second, methylates RAF1 and probably BRAF, hence destabilizing these 2 signaling proteins and reducing their catalytic activity (PubMed:21917714). Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. Methylates HOXA9 (PubMed:22269951). Methylates and regulates SRGAP2 which is involved in cell migration and differentiation (PubMed:20810653). Acts as a transcriptional corepressor in CRY1-mediated repression of the core circadian component PER1 by regulating the H4R3 dimethylation at the PER1 promoter (By similarity). Methylates GM130/GOLGA2, regulating Golgi ribbon formation (PubMed:20421892). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789). Symmetrically methylates POLR2A, a modification that allows the recruitment to POLR2A of proteins including SMN1/SMN2 and SETX. This is required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination (PubMed:26700805). Along with LYAR, binds the promoter of gamma-globin HBG1/HBG2 and represses its expression (PubMed:25092918). Symmetrically methylates NCL (PubMed:21081503). Methylates p53/TP53; methylation might possibly affect p53/TP53 target gene specificity (PubMed:19011621). Involved in spliceosome maturation and mRNA splicing in prophase I spermatocytes through the catalysis of the symmetrical arginine dimethylation of SNRPB (small nuclear ribonucleoprotein-associated protein) and the interaction with tudor domain-containing protein TDRD6 (By similarity). {ECO:0000250|UniProtKB:Q8CIG8, ECO:0000269|PubMed:10531356, ECO:0000269|PubMed:11152681, ECO:0000269|PubMed:11747828, ECO:0000269|PubMed:12411503, ECO:0000269|PubMed:12718890, ECO:0000269|PubMed:15737618, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:17709427, ECO:0000269|PubMed:19011621, ECO:0000269|PubMed:20159986, ECO:0000269|PubMed:20421892, ECO:0000269|PubMed:20810653, ECO:0000269|PubMed:21081503, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:21917714, ECO:0000269|PubMed:22269951, ECO:0000269|PubMed:25092918, ECO:0000269|PubMed:25284789, ECO:0000269|PubMed:26700805}. |
| O60749 | SNX2 | S265 | Sugiyama | Sorting nexin-2 (Transformation-related gene 9 protein) (TRG-9) | Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:16179610). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:17101778). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Required for retrograde endosome-to-TGN transport of TGN38 (PubMed:20138391). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed:20604901). {ECO:0000269|PubMed:16179610, ECO:0000269|PubMed:17101778, ECO:0000269|PubMed:20138391, ECO:0000269|PubMed:20604901, ECO:0000269|PubMed:23085988, ECO:0000303|PubMed:16179610}. |
| Q92973 | TNPO1 | S111 | Sugiyama | Transportin-1 (Importin beta-2) (Karyopherin beta-2) (M9 region interaction protein) (MIP) | Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates (PubMed:24753571). May mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Involved in nuclear import of M9-containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Involved in hnRNP A1/A2 nuclear export. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5 (PubMed:11682607). In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones (By similarity). In vitro, mediates nuclear import of SRP19 (PubMed:11682607). Mediates nuclear import of ADAR/ADAR1 isoform 1 and isoform 5 in a RanGTP-dependent manner (PubMed:19124606, PubMed:24753571). Main mediator of PR-DUB complex component BAP1 nuclear import; acts redundantly with the karyopherins KPNA1 and KPNA2 (PubMed:35446349). {ECO:0000250|UniProtKB:Q8BFY9, ECO:0000269|PubMed:11682607, ECO:0000269|PubMed:19124606, ECO:0000269|PubMed:24753571, ECO:0000269|PubMed:35446349, ECO:0000269|PubMed:8986607, ECO:0000269|PubMed:9687515}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. {ECO:0000269|PubMed:16704975}. |
| Q9BT78 | COPS4 | S298 | Sugiyama | COP9 signalosome complex subunit 4 (SGN4) (Signalosome subunit 4) (JAB1-containing signalosome subunit 4) | Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Also involved in the deneddylation of non-cullin subunits such as STON2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:21102408, ECO:0000269|PubMed:9535219}. |
| Q16600 | ZNF239 | S129 | GPS6 | Zinc finger protein 239 (Zinc finger protein HOK-2) (Zinc finger protein MOK-2) | May be involved in transcriptional regulation. |
| Q16222 | UAP1 | S484 | Sugiyama | UDP-N-acetylhexosamine pyrophosphorylase (Antigen X) (AGX) (Protein-pyrophosphorylation enzyme) (EC 2.7.4.-) (Sperm-associated antigen 2) (UDP-N-acetylgalactosamine pyrophosphorylase) (EC 2.7.7.83) (UDP-N-acetylglucosamine pyrophosphorylase) (EC 2.7.7.23) | Catalyzes the last step in biosynthesis of uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) by converting UTP and glucosamine 1-phosphate (GlcNAc-1-P) to the sugar nucleotide (PubMed:9603950, PubMed:9765219). Also converts UTP and galactosamine 1-phosphate (GalNAc-1-P) into uridine diphosphate-N-acetylgalactosamine (UDP-GalNAc) (PubMed:9765219). In addition to its role in metabolism, acts as a regulator of innate immunity in response to virus infection by mediating pyrophosphorylation of IRF3: catalyzes pyrophosphorylation of IRF3 phosphorylated at 'Ser-386' by TBK1, promoting IRF3 dimerization and activation, leading to type I interferon responses (PubMed:36603579). {ECO:0000269|PubMed:36603579, ECO:0000269|PubMed:9603950, ECO:0000269|PubMed:9765219}.; FUNCTION: [Isoform AGX1]: Isoform AGX1 has 2 to 3 times higher activity towards galactosamine 1-phosphate (GalNAc-1-P). {ECO:0000269|PubMed:9765219}.; FUNCTION: [Isoform AGX1]: Isoform AGX2 has 8 times more activity towards glucosamine 1-phosphate (GlcNAc-1-P). {ECO:0000269|PubMed:9765219}. |
| Q8TEQ6 | GEMIN5 | S648 | Sugiyama | Gem-associated protein 5 (Gemin5) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:16857593, PubMed:18984161, PubMed:20513430, PubMed:33963192). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:18984161). To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate (PubMed:18984161). Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. Within the SMN complex, GEMIN5 recognizes and delivers the small nuclear RNAs (snRNAs) to the SMN complex (PubMed:11714716, PubMed:16314521, PubMed:16857593, PubMed:19377484, PubMed:19750007, PubMed:20513430, PubMed:27834343, PubMed:27881600, PubMed:27881601). Binds to the 7-methylguanosine cap of RNA molecules (PubMed:19750007, PubMed:27834343, PubMed:27881600, PubMed:27881601, Ref.27). Binds to the 3'-UTR of SMN1 mRNA and regulates its translation; does not affect mRNA stability (PubMed:25911097). May play a role in the regulation of protein synthesis via its interaction with ribosomes (PubMed:27507887). {ECO:0000269|PubMed:11714716, ECO:0000269|PubMed:16314521, ECO:0000269|PubMed:16857593, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:19377484, ECO:0000269|PubMed:19750007, ECO:0000269|PubMed:20513430, ECO:0000269|PubMed:25911097, ECO:0000269|PubMed:27507887, ECO:0000269|PubMed:27834343, ECO:0000269|PubMed:27881600, ECO:0000269|PubMed:27881601, ECO:0000269|PubMed:33963192, ECO:0000269|Ref.27}. |
| Q13043 | STK4 | S288 | Sugiyama | Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)] | Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes. {ECO:0000250|UniProtKB:Q9JI11, ECO:0000269|PubMed:11278283, ECO:0000269|PubMed:11517310, ECO:0000269|PubMed:12757711, ECO:0000269|PubMed:15109305, ECO:0000269|PubMed:16510573, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:17932490, ECO:0000269|PubMed:18328708, ECO:0000269|PubMed:18986304, ECO:0000269|PubMed:19525978, ECO:0000269|PubMed:21212262, ECO:0000269|PubMed:21245099, ECO:0000269|PubMed:21512132, ECO:0000269|PubMed:8702870, ECO:0000269|PubMed:8816758}. |
| P42025 | ACTR1B | S247 | Sugiyama | Beta-centractin (Actin-related protein 1B) (ARP1B) | Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. |
| Q96GD4 | AURKB | S37 | Sugiyama | Aurora kinase B (EC 2.7.11.1) (Aurora 1) (Aurora- and IPL1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1-related kinase 2) (ARK-2) (Aurora-related kinase 2) (STK-1) (Serine/threonine-protein kinase 12) (Serine/threonine-protein kinase 5) (Serine/threonine-protein kinase aurora-B) | Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis (PubMed:11516652, PubMed:12925766, PubMed:14610074, PubMed:14722118, PubMed:29449677). The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly (PubMed:11516652, PubMed:12925766, PubMed:14610074, PubMed:14722118, PubMed:26829474). Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis (PubMed:15249581). Required for central/midzone spindle assembly and cleavage furrow formation (PubMed:12458200, PubMed:12686604). Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (PubMed:22422861, PubMed:24814515). AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP (PubMed:11516652, PubMed:12925766, PubMed:14610074). Phosphorylation of INCENP leads to increased AURKB activity (PubMed:11516652, PubMed:12925766, PubMed:14610074). Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPTIN1, VIM/vimentin, HASPIN, and histone H3 (PubMed:11756469, PubMed:11784863, PubMed:11856369, PubMed:12689593, PubMed:14602875, PubMed:16103226, PubMed:21658950). A positive feedback loop involving HASPIN and AURKB contributes to localization of CPC to centromeres (PubMed:21658950). Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively) (PubMed:11784863, PubMed:11856369). AURKB is also required for kinetochore localization of BUB1 and SGO1 (PubMed:15020684, PubMed:17617734). Phosphorylation of p53/TP53 negatively regulates its transcriptional activity (PubMed:20959462). Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B-cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes (By similarity). Acts as an inhibitor of CGAS during mitosis: catalyzes phosphorylation of the N-terminus of CGAS during the G2-M transition, blocking CGAS liquid phase separation and activation, and thereby preventing CGAS-induced autoimmunity (PubMed:33542149). Phosphorylates KRT5 during anaphase and telophase (By similarity). Phosphorylates ATXN10 which promotes phosphorylation of ATXN10 by PLK1 and may play a role in the regulation of cytokinesis and stimulating the proteasomal degradation of ATXN10 (PubMed:25666058). {ECO:0000250|UniProtKB:O70126, ECO:0000269|PubMed:11516652, ECO:0000269|PubMed:11756469, ECO:0000269|PubMed:11784863, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:12458200, ECO:0000269|PubMed:12686604, ECO:0000269|PubMed:12689593, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:14602875, ECO:0000269|PubMed:14610074, ECO:0000269|PubMed:14722118, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15249581, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:17617734, ECO:0000269|PubMed:20959462, ECO:0000269|PubMed:21658950, ECO:0000269|PubMed:22422861, ECO:0000269|PubMed:24814515, ECO:0000269|PubMed:25666058, ECO:0000269|PubMed:26829474, ECO:0000269|PubMed:29449677, ECO:0000269|PubMed:33542149}. |
| Q9H093 | NUAK2 | S590 | Sugiyama | NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (Omphalocele kinase 2) (SNF1/AMP kinase-related kinase) (SNARK) | Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Phosphorylates LATS1 and LATS2. Plays a key role in neural tube closure during embryonic development through LATS2 phosphorylation and regulation of the nuclear localization of YAP1 a critical downstream regulatory target in the Hippo signaling pathway (PubMed:32845958). {ECO:0000269|PubMed:14575707, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15345718, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:32845958}. |
| O95255 | ABCC6 | S66 | Sugiyama | ATP-binding cassette sub-family C member 6 (EC 7.6.2.-) (EC 7.6.2.3) (Anthracycline resistance-associated protein) (Multi-specific organic anion transporter E) (MOAT-E) (Multidrug resistance-associated protein 6) | [Isoform 1]: ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of glutathione conjugates such as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS) (in vitro), and an anionic cyclopentapeptide endothelin antagonist, BQ-123 (PubMed:11880368, PubMed:12414644). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Does not appear to actively transport drugs outside the cell. Confers low levels of cellular resistance to etoposide, teniposide, anthracyclines and cisplatin (PubMed:12414644). {ECO:0000269|PubMed:11880368, ECO:0000269|PubMed:12414644, ECO:0000305|PubMed:35307651}.; FUNCTION: [Isoform 1]: Mediates the release of nucleoside triphosphates, predominantly ATP, into the circulation, where it is rapidly converted into AMP and the mineralization inhibitor inorganic pyrophosphate (PPi) by the ecto-enzyme ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1), therefore playing a role in PPi homeostasis. {ECO:0000269|PubMed:24277820, ECO:0000269|PubMed:24969777}.; FUNCTION: [Isoform 2]: Inhibits TNF-alpha-mediated apoptosis through blocking one or more caspases. {ECO:0000269|PubMed:23912081}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-1538133 | G0 and Early G1 | 0.000061 | 4.217 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 0.001342 | 2.872 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.001160 | 2.936 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.001568 | 2.805 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.000573 | 3.242 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.000585 | 3.233 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.000802 | 3.096 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.001510 | 2.821 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.001828 | 2.738 |
| R-HSA-1640170 | Cell Cycle | 0.002086 | 2.681 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 0.003393 | 2.469 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 0.003393 | 2.469 |
| R-HSA-9762292 | Regulation of CDH11 function | 0.008654 | 2.063 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.008548 | 2.068 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.006117 | 2.213 |
| R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 0.008654 | 2.063 |
| R-HSA-4839726 | Chromatin organization | 0.008484 | 2.071 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.006192 | 2.208 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 0.005228 | 2.282 |
| R-HSA-9834752 | Respiratory syncytial virus genome replication | 0.007425 | 2.129 |
| R-HSA-9707616 | Heme signaling | 0.006914 | 2.160 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.006914 | 2.160 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.005353 | 2.271 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 0.041592 | 1.381 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 0.041592 | 1.381 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 0.041592 | 1.381 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 0.041592 | 1.381 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 0.041592 | 1.381 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 0.041592 | 1.381 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 0.041592 | 1.381 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 0.041592 | 1.381 |
| R-HSA-5690338 | Defective ABCC6 causes PXE | 0.041592 | 1.381 |
| R-HSA-5683371 | Defective ABCB6 causes MCOPCB7 | 0.041592 | 1.381 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 0.041592 | 1.381 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 0.041592 | 1.381 |
| R-HSA-9918449 | Defective visual phototransduction due to STRA6 loss of function | 0.041592 | 1.381 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 0.041592 | 1.381 |
| R-HSA-69200 | Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 ... | 0.061739 | 1.209 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 0.009967 | 2.001 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 0.071653 | 1.145 |
| R-HSA-68911 | G2 Phase | 0.071653 | 1.145 |
| R-HSA-8849470 | PTK6 Regulates Cell Cycle | 0.081464 | 1.089 |
| R-HSA-9652817 | Signaling by MAPK mutants | 0.081464 | 1.089 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 0.100777 | 0.997 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 0.100777 | 0.997 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 0.100777 | 0.997 |
| R-HSA-72731 | Recycling of eIF2:GDP | 0.100777 | 0.997 |
| R-HSA-444257 | RSK activation | 0.110282 | 0.957 |
| R-HSA-9700645 | ALK mutants bind TKIs | 0.119686 | 0.922 |
| R-HSA-2151209 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation | 0.128992 | 0.889 |
| R-HSA-451308 | Activation of Ca-permeable Kainate Receptor | 0.128992 | 0.889 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 0.138200 | 0.859 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 0.147312 | 0.832 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.147312 | 0.832 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.147312 | 0.832 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.156327 | 0.806 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 0.156327 | 0.806 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.156327 | 0.806 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.156327 | 0.806 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.156327 | 0.806 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.156327 | 0.806 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 0.165248 | 0.782 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 0.182809 | 0.738 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 0.182809 | 0.738 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.182809 | 0.738 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.065190 | 1.186 |
| R-HSA-5656121 | Translesion synthesis by POLI | 0.191452 | 0.718 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.191452 | 0.718 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.200003 | 0.699 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.080224 | 1.096 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.208465 | 0.681 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.208465 | 0.681 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.208465 | 0.681 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 0.225122 | 0.648 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.225122 | 0.648 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.233319 | 0.632 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.233319 | 0.632 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.233319 | 0.632 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.233319 | 0.632 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.241430 | 0.617 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.241430 | 0.617 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.056006 | 1.252 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.113001 | 0.947 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.249456 | 0.603 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.249456 | 0.603 |
| R-HSA-380287 | Centrosome maturation | 0.059362 | 1.226 |
| R-HSA-72187 | mRNA 3'-end processing | 0.134050 | 0.873 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 0.137640 | 0.861 |
| R-HSA-72649 | Translation initiation complex formation | 0.141251 | 0.850 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.280724 | 0.552 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.079431 | 1.100 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.079431 | 1.100 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.148534 | 0.828 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.085356 | 1.069 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.155891 | 0.807 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.174568 | 0.758 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.174568 | 0.758 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.185941 | 0.731 |
| R-HSA-9833482 | PKR-mediated signaling | 0.068152 | 1.167 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.288337 | 0.540 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.193581 | 0.713 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.191954 | 0.717 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.046023 | 1.337 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.283160 | 0.548 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.200003 | 0.699 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.106194 | 0.974 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.159595 | 0.797 |
| R-HSA-191859 | snRNP Assembly | 0.159595 | 0.797 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.071653 | 1.145 |
| R-HSA-6798695 | Neutrophil degranulation | 0.246911 | 0.607 |
| R-HSA-164940 | Nef mediated downregulation of MHC class I complex cell surface expression | 0.110282 | 0.957 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.200003 | 0.699 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.208975 | 0.680 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 0.225122 | 0.648 |
| R-HSA-4641265 | Repression of WNT target genes | 0.156327 | 0.806 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.205113 | 0.688 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.201260 | 0.696 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.241430 | 0.617 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.201260 | 0.696 |
| R-HSA-9711097 | Cellular response to starvation | 0.118993 | 0.924 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.025284 | 1.597 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.028015 | 1.553 |
| R-HSA-72172 | mRNA Splicing | 0.215923 | 0.666 |
| R-HSA-9843745 | Adipogenesis | 0.021017 | 1.677 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 0.081464 | 1.089 |
| R-HSA-5221030 | TET1,2,3 and TDG demethylate DNA | 0.128992 | 0.889 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.243999 | 0.613 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.276229 | 0.559 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.014154 | 1.849 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.014154 | 1.849 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.056687 | 1.247 |
| R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 0.273031 | 0.564 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.137640 | 0.861 |
| R-HSA-525793 | Myogenesis | 0.288337 | 0.540 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.115323 | 0.938 |
| R-HSA-5693538 | Homology Directed Repair | 0.166321 | 0.779 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.111968 | 0.951 |
| R-HSA-165159 | MTOR signalling | 0.099505 | 1.002 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.028015 | 1.553 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.259658 | 0.586 |
| R-HSA-169131 | Inhibition of PKR | 0.021016 | 1.677 |
| R-HSA-69478 | G2/M DNA replication checkpoint | 0.091172 | 1.040 |
| R-HSA-1369007 | Mitochondrial ABC transporters | 0.100777 | 0.997 |
| R-HSA-451306 | Ionotropic activity of kainate receptors | 0.138200 | 0.859 |
| R-HSA-192905 | vRNP Assembly | 0.138200 | 0.859 |
| R-HSA-202670 | ERKs are inactivated | 0.147312 | 0.832 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.156327 | 0.806 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 0.165248 | 0.782 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.257398 | 0.589 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.273031 | 0.564 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.152203 | 0.818 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.167052 | 0.777 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.129877 | 0.886 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.100664 | 0.997 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.208975 | 0.680 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.068114 | 1.167 |
| R-HSA-3371511 | HSF1 activation | 0.077137 | 1.113 |
| R-HSA-9620244 | Long-term potentiation | 0.280724 | 0.552 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.074665 | 1.127 |
| R-HSA-9834899 | Specification of the neural plate border | 0.027342 | 1.563 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.075585 | 1.122 |
| R-HSA-8873719 | RAB geranylgeranylation | 0.163316 | 0.787 |
| R-HSA-9909396 | Circadian clock | 0.021562 | 1.666 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.163756 | 0.786 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.249456 | 0.603 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.141242 | 0.850 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.071037 | 1.149 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.165248 | 0.782 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.069977 | 1.155 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.141242 | 0.850 |
| R-HSA-69275 | G2/M Transition | 0.068783 | 1.163 |
| R-HSA-913531 | Interferon Signaling | 0.260183 | 0.585 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.147312 | 0.832 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.056687 | 1.247 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.141251 | 0.850 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.155891 | 0.807 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.074064 | 1.130 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.255741 | 0.592 |
| R-HSA-68877 | Mitotic Prometaphase | 0.026510 | 1.577 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.014962 | 1.825 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.273031 | 0.564 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.174088 | 0.759 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.072023 | 1.143 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.074088 | 1.130 |
| R-HSA-210990 | PECAM1 interactions | 0.009967 | 2.001 |
| R-HSA-198753 | ERK/MAPK targets | 0.031652 | 1.500 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.053946 | 1.268 |
| R-HSA-983189 | Kinesins | 0.036543 | 1.437 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.259102 | 0.587 |
| R-HSA-69206 | G1/S Transition | 0.063162 | 1.200 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.012705 | 1.896 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.110242 | 0.958 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.065190 | 1.186 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.016057 | 1.794 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.216837 | 0.664 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.163316 | 0.787 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.271412 | 0.566 |
| R-HSA-194138 | Signaling by VEGF | 0.017453 | 1.758 |
| R-HSA-9854907 | Regulation of MITF-M dependent genes involved in metabolism | 0.051719 | 1.286 |
| R-HSA-8941284 | RUNX2 regulates chondrocyte maturation | 0.071653 | 1.145 |
| R-HSA-447038 | NrCAM interactions | 0.071653 | 1.145 |
| R-HSA-199920 | CREB phosphorylation | 0.091172 | 1.040 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.100777 | 0.997 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.029466 | 1.531 |
| R-HSA-425381 | Bicarbonate transporters | 0.138200 | 0.859 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.147312 | 0.832 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 0.156327 | 0.806 |
| R-HSA-77305 | Beta oxidation of palmitoyl-CoA to myristoyl-CoA | 0.156327 | 0.806 |
| R-HSA-9796292 | Formation of axial mesoderm | 0.165248 | 0.782 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.249456 | 0.603 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.116446 | 0.934 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.257398 | 0.589 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 0.265256 | 0.576 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.130482 | 0.884 |
| R-HSA-429947 | Deadenylation of mRNA | 0.273031 | 0.564 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.141251 | 0.850 |
| R-HSA-5617833 | Cilium Assembly | 0.183460 | 0.736 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.247911 | 0.606 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.030362 | 1.518 |
| R-HSA-844456 | The NLRP3 inflammasome | 0.225122 | 0.648 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 0.225122 | 0.648 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.185941 | 0.731 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 0.165248 | 0.782 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 0.174075 | 0.759 |
| R-HSA-2028269 | Signaling by Hippo | 0.208465 | 0.681 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 0.208465 | 0.681 |
| R-HSA-3371568 | Attenuation phase | 0.089709 | 1.047 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 0.233319 | 0.632 |
| R-HSA-9766229 | Degradation of CDH1 | 0.123415 | 0.909 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.288337 | 0.540 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.205113 | 0.688 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.205113 | 0.688 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.138809 | 0.858 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.212844 | 0.672 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.211893 | 0.674 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.053946 | 1.268 |
| R-HSA-68882 | Mitotic Anaphase | 0.108156 | 0.966 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.031424 | 1.503 |
| R-HSA-8939211 | ESR-mediated signaling | 0.057597 | 1.240 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 0.200003 | 0.699 |
| R-HSA-3928664 | Ephrin signaling | 0.216837 | 0.664 |
| R-HSA-1369062 | ABC transporters in lipid homeostasis | 0.265256 | 0.576 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.220602 | 0.656 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.247911 | 0.606 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.109580 | 0.960 |
| R-HSA-199991 | Membrane Trafficking | 0.012490 | 1.903 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.106194 | 0.974 |
| R-HSA-69236 | G1 Phase | 0.106194 | 0.974 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 0.119686 | 0.922 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.216837 | 0.664 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 0.265256 | 0.576 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.216720 | 0.664 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.031554 | 1.501 |
| R-HSA-9612973 | Autophagy | 0.281965 | 0.550 |
| R-HSA-68886 | M Phase | 0.029097 | 1.536 |
| R-HSA-73894 | DNA Repair | 0.111884 | 0.951 |
| R-HSA-9823730 | Formation of definitive endoderm | 0.233319 | 0.632 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.081385 | 1.089 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.249456 | 0.603 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 0.265256 | 0.576 |
| R-HSA-446210 | Synthesis of UDP-N-acetyl-glucosamine | 0.265256 | 0.576 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.079431 | 1.100 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.057115 | 1.243 |
| R-HSA-3000170 | Syndecan interactions | 0.265256 | 0.576 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.223646 | 0.650 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.042089 | 1.376 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.077425 | 1.111 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 0.216837 | 0.664 |
| R-HSA-2262752 | Cellular responses to stress | 0.014908 | 1.827 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 0.019516 | 1.710 |
| R-HSA-3214842 | HDMs demethylate histones | 0.280724 | 0.552 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.012477 | 1.904 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 0.191452 | 0.718 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.071080 | 1.148 |
| R-HSA-174403 | Glutathione synthesis and recycling | 0.249456 | 0.603 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.123415 | 0.909 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.170803 | 0.768 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.011176 | 1.952 |
| R-HSA-180786 | Extension of Telomeres | 0.159595 | 0.797 |
| R-HSA-9830364 | Formation of the nephric duct | 0.280724 | 0.552 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.110282 | 0.957 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.170803 | 0.768 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.259658 | 0.586 |
| R-HSA-373755 | Semaphorin interactions | 0.040665 | 1.391 |
| R-HSA-450294 | MAP kinase activation | 0.167052 | 0.777 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 0.225122 | 0.648 |
| R-HSA-445144 | Signal transduction by L1 | 0.233319 | 0.632 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.123415 | 0.909 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.123415 | 0.909 |
| R-HSA-5619084 | ABC transporter disorders | 0.232282 | 0.634 |
| R-HSA-448424 | Interleukin-17 signaling | 0.201260 | 0.696 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.163756 | 0.786 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.249456 | 0.603 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 0.257398 | 0.589 |
| R-HSA-417957 | P2Y receptors | 0.174075 | 0.759 |
| R-HSA-2453864 | Retinoid cycle disease events | 0.280724 | 0.552 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.122575 | 0.912 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.257398 | 0.589 |
| R-HSA-9675143 | Diseases of the neuronal system | 0.280724 | 0.552 |
| R-HSA-2474795 | Diseases associated with visual transduction | 0.280724 | 0.552 |
| R-HSA-418038 | Nucleotide-like (purinergic) receptors | 0.216837 | 0.664 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 0.280724 | 0.552 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.136391 | 0.865 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.208975 | 0.680 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.174568 | 0.758 |
| R-HSA-177929 | Signaling by EGFR | 0.148534 | 0.828 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 0.288337 | 0.540 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.102033 | 0.991 |
| R-HSA-373760 | L1CAM interactions | 0.161202 | 0.793 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.264796 | 0.577 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.138809 | 0.858 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.224490 | 0.649 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.147558 | 0.831 |
| R-HSA-379724 | tRNA Aminoacylation | 0.163316 | 0.787 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.139169 | 0.856 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.148627 | 0.828 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.156133 | 0.807 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.270686 | 0.568 |
| R-HSA-422475 | Axon guidance | 0.254979 | 0.593 |
| R-HSA-9675108 | Nervous system development | 0.193495 | 0.713 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.225355 | 0.647 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 0.086511 | 1.063 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.134050 | 0.873 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.295869 | 0.529 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.295869 | 0.529 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.295869 | 0.529 |
| R-HSA-193807 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol | 0.295869 | 0.529 |
| R-HSA-264876 | Insulin processing | 0.295869 | 0.529 |
| R-HSA-8953854 | Metabolism of RNA | 0.301687 | 0.520 |
| R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 0.303322 | 0.518 |
| R-HSA-171319 | Telomere Extension By Telomerase | 0.303322 | 0.518 |
| R-HSA-622312 | Inflammasomes | 0.303322 | 0.518 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.310697 | 0.508 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.310697 | 0.508 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.310697 | 0.508 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.317994 | 0.498 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.317994 | 0.498 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.317994 | 0.498 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 0.317994 | 0.498 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.318269 | 0.497 |
| R-HSA-157579 | Telomere Maintenance | 0.318269 | 0.497 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.318269 | 0.497 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.322149 | 0.492 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.322149 | 0.492 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.322149 | 0.492 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.325214 | 0.488 |
| R-HSA-2129379 | Molecules associated with elastic fibres | 0.325214 | 0.488 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.325214 | 0.488 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.325214 | 0.488 |
| R-HSA-182971 | EGFR downregulation | 0.325214 | 0.488 |
| R-HSA-3214847 | HATs acetylate histones | 0.326024 | 0.487 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.332359 | 0.478 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.332359 | 0.478 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.332359 | 0.478 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.337613 | 0.472 |
| R-HSA-354192 | Integrin signaling | 0.339428 | 0.469 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.339428 | 0.469 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.339428 | 0.469 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.339428 | 0.469 |
| R-HSA-159418 | Recycling of bile acids and salts | 0.339428 | 0.469 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.339428 | 0.469 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.339428 | 0.469 |
| R-HSA-9733709 | Cardiogenesis | 0.339428 | 0.469 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.339428 | 0.469 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.345306 | 0.462 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.345306 | 0.462 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.346422 | 0.460 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.346422 | 0.460 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.346422 | 0.460 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.346422 | 0.460 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.350852 | 0.455 |
| R-HSA-168255 | Influenza Infection | 0.351236 | 0.454 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.352971 | 0.452 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.353343 | 0.452 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.353343 | 0.452 |
| R-HSA-203615 | eNOS activation | 0.353343 | 0.452 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 0.353343 | 0.452 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.353343 | 0.452 |
| R-HSA-392518 | Signal amplification | 0.353343 | 0.452 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 0.353343 | 0.452 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.353343 | 0.452 |
| R-HSA-2559583 | Cellular Senescence | 0.354121 | 0.451 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.360192 | 0.443 |
| R-HSA-381042 | PERK regulates gene expression | 0.360192 | 0.443 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.360192 | 0.443 |
| R-HSA-69239 | Synthesis of DNA | 0.360604 | 0.443 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.360604 | 0.443 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.360604 | 0.443 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.364409 | 0.438 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.364409 | 0.438 |
| R-HSA-74160 | Gene expression (Transcription) | 0.365461 | 0.437 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.366968 | 0.435 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.366968 | 0.435 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.366968 | 0.435 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.373672 | 0.428 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.373672 | 0.428 |
| R-HSA-390247 | Beta-oxidation of very long chain fatty acids | 0.373672 | 0.428 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.380306 | 0.420 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 0.380306 | 0.420 |
| R-HSA-1566948 | Elastic fibre formation | 0.380306 | 0.420 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.380306 | 0.420 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.380306 | 0.420 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.385726 | 0.414 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.386871 | 0.412 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.386871 | 0.412 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 0.386871 | 0.412 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.386871 | 0.412 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.387049 | 0.412 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.387049 | 0.412 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.393366 | 0.405 |
| R-HSA-9646399 | Aggrephagy | 0.393366 | 0.405 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.393366 | 0.405 |
| R-HSA-379726 | Mitochondrial tRNA aminoacylation | 0.393366 | 0.405 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.393366 | 0.405 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.398238 | 0.400 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.399793 | 0.398 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.399793 | 0.398 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.399793 | 0.398 |
| R-HSA-5423646 | Aflatoxin activation and detoxification | 0.399793 | 0.398 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.401947 | 0.396 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.401947 | 0.396 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.405646 | 0.392 |
| R-HSA-162582 | Signal Transduction | 0.405863 | 0.392 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.406152 | 0.391 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.406152 | 0.391 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.406152 | 0.391 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.406152 | 0.391 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.406152 | 0.391 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.406152 | 0.391 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.412444 | 0.385 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 0.412444 | 0.385 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.412444 | 0.385 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.412444 | 0.385 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.413010 | 0.384 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.413010 | 0.384 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.413010 | 0.384 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.418669 | 0.378 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.418669 | 0.378 |
| R-HSA-3371556 | Cellular response to heat stress | 0.420329 | 0.376 |
| R-HSA-73886 | Chromosome Maintenance | 0.420329 | 0.376 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.423971 | 0.373 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.423971 | 0.373 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.424829 | 0.372 |
| R-HSA-9907900 | Proteasome assembly | 0.424829 | 0.372 |
| R-HSA-5357801 | Programmed Cell Death | 0.428210 | 0.368 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.430925 | 0.366 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.430925 | 0.366 |
| R-HSA-9824272 | Somitogenesis | 0.430925 | 0.366 |
| R-HSA-2453902 | The canonical retinoid cycle in rods (twilight vision) | 0.430925 | 0.366 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.430925 | 0.366 |
| R-HSA-77286 | mitochondrial fatty acid beta-oxidation of saturated fatty acids | 0.430925 | 0.366 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.436956 | 0.360 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.436956 | 0.360 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.436956 | 0.360 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.436956 | 0.360 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.436956 | 0.360 |
| R-HSA-9675135 | Diseases of DNA repair | 0.436956 | 0.360 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.436956 | 0.360 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.436956 | 0.360 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.436956 | 0.360 |
| R-HSA-75153 | Apoptotic execution phase | 0.436956 | 0.360 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.438420 | 0.358 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.438420 | 0.358 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.438420 | 0.358 |
| R-HSA-437239 | Recycling pathway of L1 | 0.442923 | 0.354 |
| R-HSA-69481 | G2/M Checkpoints | 0.445572 | 0.351 |
| R-HSA-5620924 | Intraflagellar transport | 0.448828 | 0.348 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.449129 | 0.348 |
| R-HSA-73893 | DNA Damage Bypass | 0.454670 | 0.342 |
| R-HSA-912446 | Meiotic recombination | 0.466171 | 0.331 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.471831 | 0.326 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.471831 | 0.326 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.471831 | 0.326 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.477431 | 0.321 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.477431 | 0.321 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.477431 | 0.321 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.477431 | 0.321 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.485836 | 0.314 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.488454 | 0.311 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.488454 | 0.311 |
| R-HSA-9753281 | Paracetamol ADME | 0.488454 | 0.311 |
| R-HSA-75893 | TNF signaling | 0.493879 | 0.306 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.493879 | 0.306 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.493879 | 0.306 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.493879 | 0.306 |
| R-HSA-5578775 | Ion homeostasis | 0.493879 | 0.306 |
| R-HSA-6807070 | PTEN Regulation | 0.494162 | 0.306 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.500883 | 0.300 |
| R-HSA-1632852 | Macroautophagy | 0.500883 | 0.300 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.504557 | 0.297 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.507548 | 0.295 |
| R-HSA-9033241 | Peroxisomal protein import | 0.509812 | 0.293 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.509812 | 0.293 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.509812 | 0.293 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.515012 | 0.288 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.515012 | 0.288 |
| R-HSA-156590 | Glutathione conjugation | 0.515012 | 0.288 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.515012 | 0.288 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.515012 | 0.288 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.515012 | 0.288 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.515012 | 0.288 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.515012 | 0.288 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.520156 | 0.284 |
| R-HSA-211976 | Endogenous sterols | 0.520156 | 0.284 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.520156 | 0.284 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.523955 | 0.281 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.525247 | 0.280 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.525247 | 0.280 |
| R-HSA-69242 | S Phase | 0.527192 | 0.278 |
| R-HSA-166520 | Signaling by NTRKs | 0.527192 | 0.278 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.530283 | 0.275 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.530283 | 0.275 |
| R-HSA-8848021 | Signaling by PTK6 | 0.530283 | 0.275 |
| R-HSA-9758941 | Gastrulation | 0.530414 | 0.275 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.533622 | 0.273 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.540198 | 0.267 |
| R-HSA-69306 | DNA Replication | 0.543156 | 0.265 |
| R-HSA-1989781 | PPARA activates gene expression | 0.549437 | 0.260 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.549437 | 0.260 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.549905 | 0.260 |
| R-HSA-9830369 | Kidney development | 0.549905 | 0.260 |
| R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 0.549905 | 0.260 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.549905 | 0.260 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.552563 | 0.258 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.554681 | 0.256 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.554681 | 0.256 |
| R-HSA-5218859 | Regulated Necrosis | 0.554681 | 0.256 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.555657 | 0.255 |
| R-HSA-877300 | Interferon gamma signaling | 0.561817 | 0.250 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.564084 | 0.249 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.564084 | 0.249 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.564084 | 0.249 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.564874 | 0.248 |
| R-HSA-3000178 | ECM proteoglycans | 0.568711 | 0.245 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.568711 | 0.245 |
| R-HSA-8978934 | Metabolism of cofactors | 0.568711 | 0.245 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.568711 | 0.245 |
| R-HSA-109581 | Apoptosis | 0.570943 | 0.243 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.573289 | 0.242 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.577819 | 0.238 |
| R-HSA-4086398 | Ca2+ pathway | 0.577819 | 0.238 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.577819 | 0.238 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.586736 | 0.232 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.586736 | 0.232 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.591124 | 0.228 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.595465 | 0.225 |
| R-HSA-216083 | Integrin cell surface interactions | 0.599761 | 0.222 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.599761 | 0.222 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.603225 | 0.220 |
| R-HSA-9659379 | Sensory processing of sound | 0.604011 | 0.219 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.604011 | 0.219 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.606068 | 0.217 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.606068 | 0.217 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.606068 | 0.217 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.608217 | 0.216 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.608217 | 0.216 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.608895 | 0.215 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.619003 | 0.208 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.620569 | 0.207 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.624600 | 0.204 |
| R-HSA-390918 | Peroxisomal lipid metabolism | 0.624600 | 0.204 |
| R-HSA-109582 | Hemostasis | 0.625755 | 0.204 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.628588 | 0.202 |
| R-HSA-1500620 | Meiosis | 0.628588 | 0.202 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.633652 | 0.198 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.639319 | 0.194 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.640301 | 0.194 |
| R-HSA-156902 | Peptide chain elongation | 0.644123 | 0.191 |
| R-HSA-9663891 | Selective autophagy | 0.644123 | 0.191 |
| R-HSA-202424 | Downstream TCR signaling | 0.651647 | 0.186 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.654266 | 0.184 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.654319 | 0.184 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.655350 | 0.184 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.655350 | 0.184 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.657176 | 0.182 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.659013 | 0.181 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.662637 | 0.179 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.662637 | 0.179 |
| R-HSA-391251 | Protein folding | 0.662637 | 0.179 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.667240 | 0.176 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.673283 | 0.172 |
| R-HSA-77289 | Mitochondrial Fatty Acid Beta-Oxidation | 0.673283 | 0.172 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.676757 | 0.170 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.676757 | 0.170 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.677066 | 0.169 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.680194 | 0.167 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.680194 | 0.167 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.681890 | 0.166 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.684280 | 0.165 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.686959 | 0.163 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.690288 | 0.161 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 0.690288 | 0.161 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.696841 | 0.157 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.696841 | 0.157 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.700066 | 0.155 |
| R-HSA-1483255 | PI Metabolism | 0.700066 | 0.155 |
| R-HSA-192823 | Viral mRNA Translation | 0.703257 | 0.153 |
| R-HSA-1266738 | Developmental Biology | 0.705159 | 0.152 |
| R-HSA-72766 | Translation | 0.706366 | 0.151 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.706413 | 0.151 |
| R-HSA-212436 | Generic Transcription Pathway | 0.706651 | 0.151 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.707385 | 0.150 |
| R-HSA-397014 | Muscle contraction | 0.707385 | 0.150 |
| R-HSA-9833110 | RSV-host interactions | 0.709537 | 0.149 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.709616 | 0.149 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.712627 | 0.147 |
| R-HSA-597592 | Post-translational protein modification | 0.713340 | 0.147 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.715685 | 0.145 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.718710 | 0.143 |
| R-HSA-211000 | Gene Silencing by RNA | 0.718710 | 0.143 |
| R-HSA-418990 | Adherens junctions interactions | 0.720563 | 0.142 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.721704 | 0.142 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 0.727596 | 0.138 |
| R-HSA-202403 | TCR signaling | 0.727596 | 0.138 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.733364 | 0.135 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.733364 | 0.135 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.733364 | 0.135 |
| R-HSA-9679506 | SARS-CoV Infections | 0.735207 | 0.134 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.741789 | 0.130 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.744538 | 0.128 |
| R-HSA-392499 | Metabolism of proteins | 0.755933 | 0.122 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.759049 | 0.120 |
| R-HSA-157118 | Signaling by NOTCH | 0.764691 | 0.117 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.768007 | 0.115 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.770478 | 0.113 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.770478 | 0.113 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.777414 | 0.109 |
| R-HSA-168249 | Innate Immune System | 0.778690 | 0.109 |
| R-HSA-114608 | Platelet degranulation | 0.780105 | 0.108 |
| R-HSA-421270 | Cell-cell junction organization | 0.784413 | 0.105 |
| R-HSA-1474165 | Reproduction | 0.789331 | 0.103 |
| R-HSA-5688426 | Deubiquitination | 0.791219 | 0.102 |
| R-HSA-5576891 | Cardiac conduction | 0.791576 | 0.102 |
| R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 0.791576 | 0.102 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.792891 | 0.101 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.795996 | 0.099 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.804559 | 0.094 |
| R-HSA-416476 | G alpha (q) signalling events | 0.805847 | 0.094 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.808705 | 0.092 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.814283 | 0.089 |
| R-HSA-449147 | Signaling by Interleukins | 0.819485 | 0.086 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.820627 | 0.086 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.821032 | 0.086 |
| R-HSA-446728 | Cell junction organization | 0.826803 | 0.083 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.826803 | 0.083 |
| R-HSA-2187338 | Visual phototransduction | 0.828161 | 0.082 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.833604 | 0.079 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.837138 | 0.077 |
| R-HSA-9609507 | Protein localization | 0.838876 | 0.076 |
| R-HSA-73887 | Death Receptor Signaling | 0.840597 | 0.075 |
| R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 0.845648 | 0.073 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.849517 | 0.071 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.851886 | 0.070 |
| R-HSA-168256 | Immune System | 0.851942 | 0.070 |
| R-HSA-195721 | Signaling by WNT | 0.853234 | 0.069 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.856825 | 0.067 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 0.861365 | 0.065 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.867197 | 0.062 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.868616 | 0.061 |
| R-HSA-1500931 | Cell-Cell communication | 0.873838 | 0.059 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.874145 | 0.058 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.881111 | 0.055 |
| R-HSA-1280218 | Adaptive Immune System | 0.885249 | 0.053 |
| R-HSA-1474244 | Extracellular matrix organization | 0.888949 | 0.051 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.890564 | 0.050 |
| R-HSA-983712 | Ion channel transport | 0.891735 | 0.050 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.898950 | 0.046 |
| R-HSA-6805567 | Keratinization | 0.910805 | 0.041 |
| R-HSA-9748784 | Drug ADME | 0.921622 | 0.035 |
| R-HSA-8951664 | Neddylation | 0.924117 | 0.034 |
| R-HSA-162906 | HIV Infection | 0.928870 | 0.032 |
| R-HSA-211859 | Biological oxidations | 0.930604 | 0.031 |
| R-HSA-72312 | rRNA processing | 0.932605 | 0.030 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 0.937508 | 0.028 |
| R-HSA-8978868 | Fatty acid metabolism | 0.943384 | 0.025 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.954315 | 0.020 |
| R-HSA-382551 | Transport of small molecules | 0.958336 | 0.018 |
| R-HSA-9658195 | Leishmania infection | 0.960308 | 0.018 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.960308 | 0.018 |
| R-HSA-9824446 | Viral Infection Pathways | 0.963882 | 0.016 |
| R-HSA-1483257 | Phospholipid metabolism | 0.965890 | 0.015 |
| R-HSA-112316 | Neuronal System | 0.967416 | 0.014 |
| R-HSA-8957322 | Metabolism of steroids | 0.975092 | 0.011 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.983871 | 0.007 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.987027 | 0.006 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.988492 | 0.005 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.988862 | 0.005 |
| R-HSA-1643685 | Disease | 0.993586 | 0.003 |
| R-HSA-388396 | GPCR downstream signalling | 0.998283 | 0.001 |
| R-HSA-5663205 | Infectious disease | 0.998299 | 0.001 |
| R-HSA-500792 | GPCR ligand binding | 0.998644 | 0.001 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.999016 | 0.000 |
| R-HSA-372790 | Signaling by GPCR | 0.999255 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999753 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999986 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
KIS |
0.832 | 0.567 | 1 | 0.901 |
CDK19 |
0.832 | 0.610 | 1 | 0.906 |
CDK18 |
0.831 | 0.627 | 1 | 0.921 |
CDK17 |
0.829 | 0.641 | 1 | 0.922 |
CDK5 |
0.829 | 0.615 | 1 | 0.891 |
CDK8 |
0.828 | 0.605 | 1 | 0.893 |
CDK16 |
0.828 | 0.636 | 1 | 0.918 |
CDK13 |
0.827 | 0.617 | 1 | 0.913 |
P38G |
0.826 | 0.644 | 1 | 0.921 |
JNK2 |
0.825 | 0.651 | 1 | 0.918 |
CDK12 |
0.823 | 0.617 | 1 | 0.921 |
CDK7 |
0.823 | 0.581 | 1 | 0.904 |
CDK14 |
0.822 | 0.644 | 1 | 0.903 |
CDK3 |
0.821 | 0.559 | 1 | 0.922 |
CDK10 |
0.821 | 0.586 | 1 | 0.915 |
CDK9 |
0.820 | 0.602 | 1 | 0.911 |
CDK1 |
0.819 | 0.594 | 1 | 0.907 |
P38D |
0.819 | 0.630 | 1 | 0.929 |
HIPK2 |
0.818 | 0.544 | 1 | 0.903 |
ERK1 |
0.818 | 0.608 | 1 | 0.909 |
JNK3 |
0.817 | 0.640 | 1 | 0.909 |
NLK |
0.816 | 0.582 | 1 | 0.740 |
CDK6 |
0.815 | 0.619 | 1 | 0.912 |
P38B |
0.815 | 0.609 | 1 | 0.898 |
DYRK2 |
0.815 | 0.558 | 1 | 0.861 |
P38A |
0.812 | 0.602 | 1 | 0.873 |
CDK4 |
0.812 | 0.619 | 1 | 0.921 |
ERK2 |
0.811 | 0.615 | 1 | 0.890 |
DYRK1B |
0.810 | 0.551 | 1 | 0.890 |
CLK3 |
0.809 | 0.328 | 1 | 0.727 |
HIPK1 |
0.809 | 0.512 | 1 | 0.857 |
HIPK4 |
0.806 | 0.325 | 1 | 0.731 |
DYRK4 |
0.805 | 0.544 | 1 | 0.911 |
CDK2 |
0.804 | 0.478 | 1 | 0.834 |
DYRK1A |
0.804 | 0.469 | 1 | 0.859 |
SRPK1 |
0.803 | 0.254 | -3 | 0.692 |
HIPK3 |
0.802 | 0.504 | 1 | 0.836 |
ERK5 |
0.801 | 0.305 | 1 | 0.657 |
SRPK2 |
0.799 | 0.220 | -3 | 0.622 |
MTOR |
0.798 | 0.247 | 1 | 0.543 |
CLK1 |
0.796 | 0.313 | -3 | 0.693 |
COT |
0.795 | -0.028 | 2 | 0.552 |
JNK1 |
0.794 | 0.570 | 1 | 0.908 |
CDKL5 |
0.793 | 0.133 | -3 | 0.741 |
DYRK3 |
0.793 | 0.419 | 1 | 0.826 |
ICK |
0.792 | 0.257 | -3 | 0.775 |
CLK4 |
0.791 | 0.276 | -3 | 0.715 |
CDKL1 |
0.790 | 0.123 | -3 | 0.751 |
CLK2 |
0.789 | 0.292 | -3 | 0.687 |
GCN2 |
0.789 | -0.095 | 2 | 0.533 |
ULK2 |
0.789 | -0.058 | 2 | 0.556 |
NIM1 |
0.788 | 0.115 | 3 | 0.802 |
SRPK3 |
0.787 | 0.199 | -3 | 0.672 |
MAK |
0.783 | 0.370 | -2 | 0.716 |
CDC7 |
0.782 | -0.068 | 1 | 0.399 |
PRP4 |
0.782 | 0.348 | -3 | 0.736 |
PRPK |
0.782 | -0.083 | -1 | 0.801 |
ERK7 |
0.781 | 0.180 | 2 | 0.344 |
IRE1 |
0.781 | 0.021 | 1 | 0.428 |
PKCD |
0.780 | 0.006 | 2 | 0.512 |
IRE2 |
0.780 | 0.046 | 2 | 0.578 |
TBK1 |
0.779 | -0.095 | 1 | 0.352 |
MST4 |
0.779 | -0.006 | 2 | 0.492 |
MOK |
0.779 | 0.349 | 1 | 0.772 |
NEK6 |
0.778 | -0.052 | -2 | 0.887 |
ULK1 |
0.778 | -0.087 | -3 | 0.782 |
TGFBR2 |
0.777 | -0.042 | -2 | 0.839 |
MARK4 |
0.777 | 0.025 | 4 | 0.767 |
CAMK1B |
0.777 | -0.035 | -3 | 0.818 |
NDR2 |
0.777 | -0.054 | -3 | 0.751 |
PKN3 |
0.777 | -0.031 | -3 | 0.757 |
NDR1 |
0.776 | -0.045 | -3 | 0.759 |
P90RSK |
0.776 | -0.002 | -3 | 0.712 |
NUAK2 |
0.776 | 0.011 | -3 | 0.778 |
WNK1 |
0.775 | -0.037 | -2 | 0.850 |
RSK2 |
0.775 | -0.005 | -3 | 0.714 |
BMPR2 |
0.775 | -0.109 | -2 | 0.891 |
PIM3 |
0.775 | -0.065 | -3 | 0.760 |
PKN2 |
0.774 | -0.019 | -3 | 0.781 |
NIK |
0.774 | -0.026 | -3 | 0.831 |
ATR |
0.774 | -0.048 | 1 | 0.459 |
MOS |
0.774 | -0.083 | 1 | 0.455 |
PDHK4 |
0.774 | -0.136 | 1 | 0.464 |
DSTYK |
0.774 | -0.126 | 2 | 0.514 |
PRKD1 |
0.773 | -0.043 | -3 | 0.741 |
CHAK2 |
0.773 | -0.051 | -1 | 0.766 |
PDHK1 |
0.773 | -0.124 | 1 | 0.445 |
IKKE |
0.773 | -0.126 | 1 | 0.345 |
RSK3 |
0.773 | -0.021 | -3 | 0.701 |
PKCB |
0.772 | -0.009 | 2 | 0.468 |
NEK7 |
0.772 | -0.124 | -3 | 0.817 |
RAF1 |
0.772 | -0.158 | 1 | 0.406 |
PKCA |
0.772 | 0.011 | 2 | 0.462 |
AMPKA1 |
0.772 | -0.012 | -3 | 0.785 |
WNK3 |
0.771 | -0.072 | 1 | 0.414 |
PKCG |
0.771 | -0.010 | 2 | 0.473 |
MELK |
0.770 | 0.016 | -3 | 0.744 |
NEK9 |
0.770 | -0.109 | 2 | 0.537 |
PLK4 |
0.770 | 0.014 | 2 | 0.509 |
PRKD2 |
0.770 | -0.029 | -3 | 0.694 |
AMPKA2 |
0.769 | -0.000 | -3 | 0.750 |
TSSK1 |
0.769 | 0.009 | -3 | 0.801 |
DAPK2 |
0.769 | 0.001 | -3 | 0.820 |
CAMLCK |
0.768 | -0.022 | -2 | 0.839 |
LATS2 |
0.768 | -0.047 | -5 | 0.785 |
CAMK2G |
0.768 | -0.128 | 2 | 0.512 |
MLK1 |
0.768 | -0.136 | 2 | 0.516 |
PKCZ |
0.768 | -0.027 | 2 | 0.510 |
PKACG |
0.768 | -0.017 | -2 | 0.730 |
PHKG1 |
0.768 | -0.054 | -3 | 0.761 |
PAK3 |
0.767 | -0.036 | -2 | 0.755 |
PIM1 |
0.767 | -0.019 | -3 | 0.717 |
QIK |
0.767 | 0.000 | -3 | 0.790 |
PKCH |
0.766 | -0.023 | 2 | 0.479 |
SKMLCK |
0.766 | -0.056 | -2 | 0.835 |
RIPK3 |
0.766 | -0.086 | 3 | 0.730 |
MLK3 |
0.766 | -0.072 | 2 | 0.472 |
MNK2 |
0.766 | -0.024 | -2 | 0.783 |
P70S6KB |
0.766 | -0.029 | -3 | 0.744 |
PINK1 |
0.766 | 0.146 | 1 | 0.609 |
HUNK |
0.766 | -0.139 | 2 | 0.522 |
MASTL |
0.765 | -0.121 | -2 | 0.813 |
BCKDK |
0.765 | -0.121 | -1 | 0.783 |
MNK1 |
0.765 | -0.003 | -2 | 0.797 |
QSK |
0.764 | 0.015 | 4 | 0.757 |
TSSK2 |
0.764 | -0.047 | -5 | 0.784 |
MLK2 |
0.764 | -0.141 | 2 | 0.530 |
NUAK1 |
0.764 | -0.012 | -3 | 0.723 |
PAK1 |
0.764 | -0.036 | -2 | 0.750 |
SGK3 |
0.763 | 0.043 | -3 | 0.691 |
LATS1 |
0.763 | 0.026 | -3 | 0.760 |
AURC |
0.763 | -0.008 | -2 | 0.648 |
PRKD3 |
0.762 | -0.024 | -3 | 0.682 |
VRK2 |
0.762 | 0.124 | 1 | 0.513 |
NEK2 |
0.762 | -0.079 | 2 | 0.527 |
IKKB |
0.762 | -0.212 | -2 | 0.745 |
MAPKAPK3 |
0.762 | -0.078 | -3 | 0.699 |
PLK1 |
0.762 | -0.010 | -2 | 0.855 |
PKCT |
0.762 | -0.010 | 2 | 0.488 |
CHAK1 |
0.761 | -0.114 | 2 | 0.515 |
DCAMKL1 |
0.761 | 0.013 | -3 | 0.708 |
PKR |
0.761 | -0.071 | 1 | 0.452 |
AKT2 |
0.761 | 0.026 | -3 | 0.637 |
TTBK2 |
0.761 | -0.158 | 2 | 0.502 |
IRAK4 |
0.760 | -0.024 | 1 | 0.418 |
SIK |
0.760 | -0.017 | -3 | 0.702 |
MPSK1 |
0.760 | 0.070 | 1 | 0.472 |
CAMK2D |
0.760 | -0.126 | -3 | 0.788 |
ANKRD3 |
0.760 | -0.123 | 1 | 0.441 |
BRSK2 |
0.760 | -0.063 | -3 | 0.755 |
MLK4 |
0.760 | -0.089 | 2 | 0.489 |
PAK6 |
0.759 | -0.017 | -2 | 0.693 |
RIPK1 |
0.759 | -0.135 | 1 | 0.421 |
SNRK |
0.759 | -0.065 | 2 | 0.537 |
MARK3 |
0.759 | 0.012 | 4 | 0.722 |
GRK5 |
0.759 | -0.182 | -3 | 0.824 |
PKCI |
0.758 | 0.001 | 2 | 0.488 |
FAM20C |
0.758 | -0.053 | 2 | 0.354 |
CAMK4 |
0.758 | -0.081 | -3 | 0.763 |
PHKG2 |
0.758 | -0.028 | -3 | 0.749 |
MARK2 |
0.758 | 0.006 | 4 | 0.677 |
RSK4 |
0.757 | -0.021 | -3 | 0.669 |
BRSK1 |
0.757 | -0.054 | -3 | 0.721 |
ALK4 |
0.757 | -0.040 | -2 | 0.830 |
PERK |
0.757 | -0.076 | -2 | 0.877 |
PAK2 |
0.757 | -0.041 | -2 | 0.740 |
AKT1 |
0.756 | 0.033 | -3 | 0.647 |
PKG2 |
0.756 | -0.011 | -2 | 0.667 |
PIM2 |
0.756 | 0.007 | -3 | 0.693 |
PKACB |
0.755 | -0.000 | -2 | 0.662 |
DCAMKL2 |
0.755 | -0.013 | -3 | 0.746 |
DNAPK |
0.755 | -0.041 | 1 | 0.395 |
AURB |
0.754 | -0.018 | -2 | 0.642 |
MSK2 |
0.754 | -0.060 | -3 | 0.678 |
WNK4 |
0.754 | -0.033 | -2 | 0.846 |
MAPKAPK2 |
0.754 | -0.070 | -3 | 0.650 |
SMG1 |
0.754 | -0.062 | 1 | 0.429 |
SSTK |
0.753 | -0.008 | 4 | 0.757 |
HRI |
0.753 | -0.073 | -2 | 0.879 |
PKCE |
0.753 | 0.016 | 2 | 0.462 |
ATM |
0.753 | -0.087 | 1 | 0.408 |
IKKA |
0.753 | -0.152 | -2 | 0.737 |
MEK1 |
0.752 | -0.126 | 2 | 0.538 |
DLK |
0.752 | -0.250 | 1 | 0.417 |
GRK1 |
0.752 | -0.099 | -2 | 0.769 |
MARK1 |
0.752 | -0.015 | 4 | 0.739 |
ZAK |
0.751 | -0.088 | 1 | 0.391 |
CAMK1G |
0.751 | -0.047 | -3 | 0.717 |
TGFBR1 |
0.751 | -0.073 | -2 | 0.804 |
MST3 |
0.751 | -0.020 | 2 | 0.493 |
GRK6 |
0.750 | -0.162 | 1 | 0.397 |
BMPR1B |
0.750 | -0.065 | 1 | 0.354 |
GSK3A |
0.749 | 0.120 | 4 | 0.408 |
YSK4 |
0.749 | -0.169 | 1 | 0.370 |
MEKK2 |
0.749 | -0.057 | 2 | 0.540 |
PKN1 |
0.749 | -0.001 | -3 | 0.678 |
PLK3 |
0.749 | -0.096 | 2 | 0.501 |
MEKK1 |
0.749 | -0.114 | 1 | 0.419 |
GRK7 |
0.749 | -0.029 | 1 | 0.406 |
NEK5 |
0.748 | -0.078 | 1 | 0.424 |
MEK5 |
0.748 | -0.113 | 2 | 0.541 |
TAO3 |
0.747 | -0.025 | 1 | 0.428 |
TAO2 |
0.746 | 0.000 | 2 | 0.536 |
TLK2 |
0.746 | -0.124 | 1 | 0.390 |
PRKX |
0.746 | -0.001 | -3 | 0.604 |
CAMK2B |
0.745 | -0.122 | 2 | 0.457 |
MSK1 |
0.745 | -0.047 | -3 | 0.680 |
CAMK2A |
0.745 | -0.102 | 2 | 0.459 |
AKT3 |
0.745 | 0.025 | -3 | 0.564 |
ACVR2A |
0.744 | -0.083 | -2 | 0.831 |
MEKK6 |
0.744 | 0.005 | 1 | 0.403 |
BRAF |
0.744 | -0.104 | -4 | 0.815 |
MYLK4 |
0.743 | -0.062 | -2 | 0.749 |
DRAK1 |
0.743 | -0.137 | 1 | 0.364 |
HGK |
0.743 | 0.005 | 3 | 0.907 |
P70S6K |
0.743 | -0.041 | -3 | 0.659 |
GRK4 |
0.743 | -0.222 | -2 | 0.811 |
ACVR2B |
0.742 | -0.098 | -2 | 0.836 |
PAK5 |
0.742 | -0.044 | -2 | 0.630 |
SGK1 |
0.742 | 0.043 | -3 | 0.551 |
TNIK |
0.741 | 0.020 | 3 | 0.914 |
TTBK1 |
0.741 | -0.128 | 2 | 0.471 |
AURA |
0.741 | -0.041 | -2 | 0.610 |
CHK1 |
0.741 | -0.112 | -3 | 0.740 |
PKACA |
0.741 | -0.010 | -2 | 0.616 |
NEK8 |
0.741 | -0.095 | 2 | 0.546 |
MEKK3 |
0.741 | -0.139 | 1 | 0.405 |
SMMLCK |
0.741 | -0.034 | -3 | 0.771 |
NEK4 |
0.740 | -0.056 | 1 | 0.400 |
ALK2 |
0.740 | -0.110 | -2 | 0.818 |
TLK1 |
0.739 | -0.115 | -2 | 0.833 |
MAP3K15 |
0.739 | -0.029 | 1 | 0.397 |
LKB1 |
0.739 | -0.059 | -3 | 0.795 |
MAPKAPK5 |
0.739 | -0.121 | -3 | 0.668 |
GSK3B |
0.739 | 0.015 | 4 | 0.404 |
NEK11 |
0.739 | -0.094 | 1 | 0.424 |
PDK1 |
0.739 | -0.028 | 1 | 0.452 |
CK1E |
0.739 | -0.028 | -3 | 0.555 |
MINK |
0.738 | -0.029 | 1 | 0.390 |
PAK4 |
0.737 | -0.050 | -2 | 0.632 |
LOK |
0.737 | -0.052 | -2 | 0.795 |
IRAK1 |
0.736 | -0.152 | -1 | 0.697 |
STK33 |
0.736 | -0.091 | 2 | 0.438 |
CAMKK1 |
0.736 | -0.132 | -2 | 0.798 |
PBK |
0.736 | 0.005 | 1 | 0.420 |
LRRK2 |
0.736 | -0.005 | 2 | 0.549 |
NEK1 |
0.736 | -0.035 | 1 | 0.407 |
NEK3 |
0.735 | -0.030 | 1 | 0.407 |
BUB1 |
0.735 | 0.008 | -5 | 0.759 |
EEF2K |
0.735 | -0.039 | 3 | 0.876 |
CAMK1D |
0.735 | -0.049 | -3 | 0.625 |
KHS1 |
0.734 | -0.009 | 1 | 0.396 |
MRCKA |
0.734 | 0.015 | -3 | 0.694 |
GAK |
0.734 | -0.053 | 1 | 0.463 |
CK1G1 |
0.734 | -0.052 | -3 | 0.538 |
CAMKK2 |
0.733 | -0.115 | -2 | 0.797 |
YSK1 |
0.733 | -0.036 | 2 | 0.508 |
SBK |
0.733 | 0.061 | -3 | 0.521 |
BMPR1A |
0.733 | -0.081 | 1 | 0.338 |
GCK |
0.733 | -0.065 | 1 | 0.402 |
MRCKB |
0.733 | -0.004 | -3 | 0.683 |
KHS2 |
0.733 | 0.009 | 1 | 0.410 |
GRK2 |
0.732 | -0.114 | -2 | 0.680 |
ROCK2 |
0.732 | 0.004 | -3 | 0.716 |
DAPK3 |
0.731 | -0.017 | -3 | 0.738 |
HPK1 |
0.731 | -0.051 | 1 | 0.400 |
CK1D |
0.729 | -0.021 | -3 | 0.508 |
CHK2 |
0.729 | -0.031 | -3 | 0.585 |
HASPIN |
0.728 | 0.010 | -1 | 0.628 |
MST2 |
0.728 | -0.122 | 1 | 0.390 |
CAMK1A |
0.728 | -0.030 | -3 | 0.591 |
VRK1 |
0.727 | -0.088 | 2 | 0.573 |
MYO3B |
0.726 | 0.015 | 2 | 0.536 |
MEK2 |
0.725 | -0.113 | 2 | 0.545 |
MST1 |
0.725 | -0.109 | 1 | 0.384 |
RIPK2 |
0.725 | -0.132 | 1 | 0.369 |
DAPK1 |
0.724 | -0.014 | -3 | 0.728 |
CK1A2 |
0.724 | -0.039 | -3 | 0.509 |
PASK |
0.724 | -0.133 | -3 | 0.778 |
SLK |
0.724 | -0.093 | -2 | 0.738 |
ROCK1 |
0.724 | 0.009 | -3 | 0.694 |
DMPK1 |
0.723 | 0.019 | -3 | 0.704 |
TAO1 |
0.723 | -0.026 | 1 | 0.380 |
PKG1 |
0.721 | -0.035 | -2 | 0.587 |
TTK |
0.721 | -0.014 | -2 | 0.861 |
MYO3A |
0.719 | -0.009 | 1 | 0.412 |
BIKE |
0.719 | -0.016 | 1 | 0.414 |
TAK1 |
0.718 | -0.197 | 1 | 0.400 |
ASK1 |
0.717 | -0.053 | 1 | 0.390 |
OSR1 |
0.716 | -0.082 | 2 | 0.506 |
PLK2 |
0.715 | -0.089 | -3 | 0.759 |
LIMK2_TYR |
0.714 | 0.118 | -3 | 0.840 |
CRIK |
0.714 | -0.012 | -3 | 0.635 |
PDHK3_TYR |
0.713 | 0.056 | 4 | 0.807 |
CK2A2 |
0.713 | -0.102 | 1 | 0.302 |
AAK1 |
0.713 | 0.016 | 1 | 0.389 |
YANK3 |
0.713 | -0.057 | 2 | 0.302 |
GRK3 |
0.713 | -0.127 | -2 | 0.629 |
PKMYT1_TYR |
0.711 | 0.143 | 3 | 0.868 |
TESK1_TYR |
0.709 | 0.012 | 3 | 0.904 |
LIMK1_TYR |
0.704 | 0.032 | 2 | 0.571 |
MAP2K4_TYR |
0.704 | -0.014 | -1 | 0.834 |
CK2A1 |
0.703 | -0.109 | 1 | 0.286 |
MAP2K7_TYR |
0.703 | -0.070 | 2 | 0.559 |
PDHK4_TYR |
0.703 | -0.025 | 2 | 0.547 |
TNNI3K_TYR |
0.701 | 0.012 | 1 | 0.453 |
PINK1_TYR |
0.700 | -0.089 | 1 | 0.466 |
MAP2K6_TYR |
0.700 | -0.046 | -1 | 0.829 |
ROS1 |
0.699 | -0.005 | 3 | 0.810 |
BMPR2_TYR |
0.697 | -0.038 | -1 | 0.798 |
RET |
0.697 | -0.096 | 1 | 0.427 |
STLK3 |
0.695 | -0.157 | 1 | 0.368 |
TYRO3 |
0.695 | -0.058 | 3 | 0.838 |
ALPHAK3 |
0.695 | -0.106 | -1 | 0.690 |
MST1R |
0.695 | -0.060 | 3 | 0.839 |
TYK2 |
0.695 | -0.122 | 1 | 0.413 |
JAK2 |
0.694 | -0.074 | 1 | 0.430 |
PDHK1_TYR |
0.693 | -0.127 | -1 | 0.814 |
NEK10_TYR |
0.693 | -0.079 | 1 | 0.367 |
TNK1 |
0.693 | -0.008 | 3 | 0.813 |
EPHA6 |
0.692 | -0.090 | -1 | 0.744 |
CSF1R |
0.691 | -0.058 | 3 | 0.815 |
DDR1 |
0.689 | -0.080 | 4 | 0.741 |
JAK3 |
0.689 | -0.093 | 1 | 0.408 |
JAK1 |
0.688 | -0.049 | 1 | 0.378 |
FGFR1 |
0.688 | -0.016 | 3 | 0.780 |
EPHB4 |
0.687 | -0.127 | -1 | 0.746 |
CK1A |
0.687 | -0.069 | -3 | 0.421 |
PDGFRB |
0.687 | -0.113 | 3 | 0.831 |
TEK |
0.687 | 0.018 | 3 | 0.762 |
FGFR2 |
0.686 | -0.041 | 3 | 0.794 |
PDGFRA |
0.684 | -0.086 | 3 | 0.833 |
YES1 |
0.683 | -0.090 | -1 | 0.763 |
KDR |
0.683 | -0.045 | 3 | 0.762 |
ABL2 |
0.683 | -0.109 | -1 | 0.705 |
FLT3 |
0.683 | -0.090 | 3 | 0.834 |
INSRR |
0.683 | -0.092 | 3 | 0.766 |
TNK2 |
0.682 | -0.110 | 3 | 0.773 |
WEE1_TYR |
0.681 | -0.046 | -1 | 0.669 |
ABL1 |
0.681 | -0.105 | -1 | 0.700 |
FGR |
0.680 | -0.154 | 1 | 0.407 |
TXK |
0.679 | -0.115 | 1 | 0.367 |
YANK2 |
0.678 | -0.075 | 2 | 0.307 |
ITK |
0.678 | -0.136 | -1 | 0.703 |
DDR2 |
0.677 | -0.026 | 3 | 0.741 |
HCK |
0.677 | -0.131 | -1 | 0.722 |
KIT |
0.676 | -0.124 | 3 | 0.812 |
AXL |
0.676 | -0.130 | 3 | 0.787 |
LCK |
0.676 | -0.111 | -1 | 0.711 |
ALK |
0.674 | -0.092 | 3 | 0.749 |
FER |
0.674 | -0.180 | 1 | 0.405 |
EPHA4 |
0.674 | -0.140 | 2 | 0.477 |
BLK |
0.673 | -0.100 | -1 | 0.727 |
MERTK |
0.673 | -0.120 | 3 | 0.787 |
EPHB3 |
0.672 | -0.174 | -1 | 0.724 |
FGFR3 |
0.672 | -0.069 | 3 | 0.761 |
LTK |
0.672 | -0.112 | 3 | 0.757 |
EPHB1 |
0.672 | -0.186 | 1 | 0.378 |
EPHB2 |
0.671 | -0.163 | -1 | 0.717 |
MET |
0.671 | -0.133 | 3 | 0.808 |
INSR |
0.671 | -0.110 | 3 | 0.749 |
CK1G3 |
0.670 | -0.059 | -3 | 0.374 |
PTK6 |
0.670 | -0.135 | -1 | 0.627 |
FLT4 |
0.670 | -0.111 | 3 | 0.743 |
TEC |
0.669 | -0.134 | -1 | 0.641 |
EPHA1 |
0.669 | -0.126 | 3 | 0.789 |
SRMS |
0.668 | -0.205 | 1 | 0.375 |
BTK |
0.668 | -0.190 | -1 | 0.673 |
BMX |
0.667 | -0.129 | -1 | 0.617 |
FRK |
0.666 | -0.121 | -1 | 0.719 |
NTRK2 |
0.666 | -0.169 | 3 | 0.767 |
PTK2B |
0.666 | -0.086 | -1 | 0.677 |
ERBB2 |
0.666 | -0.164 | 1 | 0.371 |
FLT1 |
0.665 | -0.152 | -1 | 0.716 |
NTRK1 |
0.664 | -0.188 | -1 | 0.735 |
EPHA7 |
0.664 | -0.157 | 2 | 0.498 |
EPHA3 |
0.663 | -0.168 | 2 | 0.486 |
MUSK |
0.663 | -0.098 | 1 | 0.310 |
MATK |
0.660 | -0.107 | -1 | 0.638 |
FYN |
0.660 | -0.122 | -1 | 0.690 |
EGFR |
0.659 | -0.118 | 1 | 0.321 |
NTRK3 |
0.659 | -0.155 | -1 | 0.684 |
LYN |
0.657 | -0.163 | 3 | 0.731 |
EPHA8 |
0.654 | -0.153 | -1 | 0.690 |
SRC |
0.654 | -0.142 | -1 | 0.699 |
EPHA5 |
0.653 | -0.178 | 2 | 0.477 |
FGFR4 |
0.652 | -0.133 | -1 | 0.670 |
IGF1R |
0.651 | -0.115 | 3 | 0.685 |
CSK |
0.650 | -0.176 | 2 | 0.519 |
PTK2 |
0.650 | -0.106 | -1 | 0.679 |
ERBB4 |
0.642 | -0.120 | 1 | 0.313 |
SYK |
0.642 | -0.132 | -1 | 0.653 |
EPHA2 |
0.641 | -0.169 | -1 | 0.653 |
FES |
0.634 | -0.124 | -1 | 0.596 |
ZAP70 |
0.634 | -0.089 | -1 | 0.600 |
CK1G2 |
0.632 | -0.098 | -3 | 0.462 |