Motif 836 (n=187)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0J9YX44 | TRBV5-5 | S26 | ochoa | T cell receptor beta variable 5-5 | None |
| A0JNW5 | BLTP3B | S884 | ochoa | Bridge-like lipid transfer protein family member 3B (Syntaxin-6 Habc-interacting protein of 164 kDa) (UHRF1-binding protein 1-like) | Tube-forming lipid transport protein which mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567). Required for retrograde traffic of vesicle clusters in the early endocytic pathway to the Golgi complex (PubMed:20163565, PubMed:35499567). {ECO:0000269|PubMed:20163565, ECO:0000269|PubMed:35499567}. |
| O00291 | HIP1 | S857 | ochoa | Huntingtin-interacting protein 1 (HIP-1) (Huntingtin-interacting protein I) (HIP-I) | Plays a role in clathrin-mediated endocytosis and trafficking (PubMed:11532990, PubMed:11577110, PubMed:11889126). Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner (By similarity). Regulates presynaptic nerve terminal activity (By similarity). Enhances androgen receptor (AR)-mediated transcription (PubMed:16027218). May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway (PubMed:11007801). Binds 3-phosphoinositides (via ENTH domain) (PubMed:14732715). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis (PubMed:14732715). May play a functional role in the cell filament networks (PubMed:18790740). May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors (PubMed:11007801, PubMed:12163454). {ECO:0000250|UniProtKB:Q8VD75, ECO:0000269|PubMed:11007801, ECO:0000269|PubMed:11532990, ECO:0000269|PubMed:11577110, ECO:0000269|PubMed:11889126, ECO:0000269|PubMed:12163454, ECO:0000269|PubMed:14732715, ECO:0000269|PubMed:16027218, ECO:0000269|PubMed:18790740, ECO:0000269|PubMed:9147654}. |
| O00299 | CLIC1 | S146 | ochoa | Chloride intracellular channel protein 1 (Chloride channel ABP) (Glutaredoxin-like oxidoreductase CLIC1) (EC 1.8.-.-) (Glutathione-dependent dehydroascorbate reductase CLIC1) (EC 1.8.5.1) (Nuclear chloride ion channel 27) (NCC27) (Regulatory nuclear chloride ion channel protein) (hRNCC) | In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Reduces selenite and dehydroascorbate and may act as an antioxidant during oxidative stress response (PubMed:25581026, PubMed:37759794). Can insert into membranes and form voltage-dependent multi-ion conductive channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions. Involved in regulation of the cell cycle. {ECO:0000269|PubMed:10834939, ECO:0000269|PubMed:10874038, ECO:0000269|PubMed:11195932, ECO:0000269|PubMed:11551966, ECO:0000269|PubMed:11940526, ECO:0000269|PubMed:11978800, ECO:0000269|PubMed:14613939, ECO:0000269|PubMed:16339885, ECO:0000269|PubMed:25581026, ECO:0000269|PubMed:37759794, ECO:0000269|PubMed:9139710}. |
| O00423 | EML1 | S113 | ochoa | Echinoderm microtubule-associated protein-like 1 (EMAP-1) (HuEMAP-1) | Modulates the assembly and organization of the microtubule cytoskeleton, and probably plays a role in regulating the orientation of the mitotic spindle and the orientation of the plane of cell division. Required for normal proliferation of neuronal progenitor cells in the developing brain and for normal brain development. Does not affect neuron migration per se. {ECO:0000250|UniProtKB:Q05BC3}. |
| O14490 | DLGAP1 | S397 | ochoa | Disks large-associated protein 1 (DAP-1) (Guanylate kinase-associated protein) (hGKAP) (PSD-95/SAP90-binding protein 1) (SAP90/PSD-95-associated protein 1) (SAPAP1) | Part of the postsynaptic scaffold in neuronal cells. |
| O14490 | DLGAP1 | S431 | ochoa | Disks large-associated protein 1 (DAP-1) (Guanylate kinase-associated protein) (hGKAP) (PSD-95/SAP90-binding protein 1) (SAP90/PSD-95-associated protein 1) (SAPAP1) | Part of the postsynaptic scaffold in neuronal cells. |
| O14578 | CIT | S440 | ochoa | Citron Rho-interacting kinase (CRIK) (EC 2.7.11.1) (Serine/threonine-protein kinase 21) | Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2. {ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:27453578}. |
| O15067 | PFAS | S569 | ochoa | Phosphoribosylformylglycinamidine synthase (FGAM synthase) (FGAMS) (EC 6.3.5.3) (Formylglycinamide ribonucleotide amidotransferase) (FGAR amidotransferase) (FGAR-AT) (Formylglycinamide ribotide amidotransferase) (Phosphoribosylformylglycineamide amidotransferase) | Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. {ECO:0000305|PubMed:10548741}. |
| O15360 | FANCA | S1377 | ochoa | Fanconi anemia group A protein (Protein FACA) | DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be involved in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. |
| O60684 | KPNA6 | S109 | ochoa | Importin subunit alpha-7 (Karyopherin subunit alpha-6) | Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. {ECO:0000269|PubMed:10523667}. |
| O60704 | TPST2 | S40 | ochoa | Protein-tyrosine sulfotransferase 2 (EC 2.8.2.20) (Tyrosylprotein sulfotransferase 2) (TPST-2) | Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate. {ECO:0000269|PubMed:9733778}. |
| O75165 | DNAJC13 | S2151 | ochoa | DnaJ homolog subfamily C member 13 (Required for receptor-mediated endocytosis 8) (RME-8) | Involved in membrane trafficking through early endosomes, such as the early endosome to recycling endosome transport implicated in the recycling of transferrin and the early endosome to late endosome transport implicated in degradation of EGF and EGFR (PubMed:18256511, PubMed:18307993). Involved in the regulation of endosomal membrane tubulation and regulates the dynamics of SNX1 on the endosomal membrane; via association with WASHC2 may link the WASH complex to the retromer SNX-BAR subcomplex (PubMed:24643499). {ECO:0000269|PubMed:18256511, ECO:0000269|PubMed:18307993, ECO:0000269|PubMed:24643499}. |
| O75448 | MED24 | S873 | ochoa | Mediator of RNA polymerase II transcription subunit 24 (Activator-recruited cofactor 100 kDa component) (ARC100) (Cofactor required for Sp1 transcriptional activation subunit 4) (CRSP complex subunit 4) (Mediator complex subunit 24) (Thyroid hormone receptor-associated protein 4) (Thyroid hormone receptor-associated protein complex 100 kDa component) (Trap100) (hTRAP100) (Vitamin D3 receptor-interacting protein complex 100 kDa component) (DRIP100) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:16595664}. |
| O75469 | NR1I2 | S350 | psp | Nuclear receptor subfamily 1 group I member 2 (Orphan nuclear receptor PAR1) (Orphan nuclear receptor PXR) (Pregnane X receptor) (Steroid and xenobiotic receptor) (SXR) | Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes. {ECO:0000269|PubMed:11297522, ECO:0000269|PubMed:11668216, ECO:0000269|PubMed:12578355, ECO:0000269|PubMed:18768384, ECO:0000269|PubMed:19297428, ECO:0000269|PubMed:9727070}. |
| O94913 | PCF11 | S705 | ochoa | Pre-mRNA cleavage complex 2 protein Pcf11 (Pre-mRNA cleavage complex II protein Pcf11) | Component of pre-mRNA cleavage complex II, which promotes transcription termination by RNA polymerase II. {ECO:0000269|PubMed:11060040, ECO:0000269|PubMed:29196535}. |
| O94953 | KDM4B | S197 | ochoa | Lysine-specific demethylase 4B (EC 1.14.11.66) (JmjC domain-containing histone demethylation protein 3B) (Jumonji domain-containing protein 2B) ([histone H3]-trimethyl-L-lysine(9) demethylase 4B) | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate (PubMed:16603238, PubMed:28262558). Plays a critical role in the development of the central nervous system (CNS). {ECO:0000250|UniProtKB:Q91VY5, ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:28262558}. |
| O94953 | KDM4B | S352 | ochoa|psp | Lysine-specific demethylase 4B (EC 1.14.11.66) (JmjC domain-containing histone demethylation protein 3B) (Jumonji domain-containing protein 2B) ([histone H3]-trimethyl-L-lysine(9) demethylase 4B) | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate (PubMed:16603238, PubMed:28262558). Plays a critical role in the development of the central nervous system (CNS). {ECO:0000250|UniProtKB:Q91VY5, ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:28262558}. |
| O94956 | SLCO2B1 | S688 | ochoa | Solute carrier organic anion transporter family member 2B1 (Organic anion transporter B) (OATP-B) (Organic anion transporter polypeptide-related protein 2) (OATP-RP2) (OATPRP2) (Organic anion transporting polypeptide 2B1) (OATP2B1) (Solute carrier family 21 member 9) | Mediates the Na(+)-independent transport of steroid sulfate conjugates and other specific organic anions (PubMed:10873595, PubMed:11159893, PubMed:11932330, PubMed:12724351, PubMed:14610227, PubMed:16908597, PubMed:18501590, PubMed:20507927, PubMed:22201122, PubMed:23531488, PubMed:25132355, PubMed:26383540, PubMed:27576593, PubMed:28408210, PubMed:29871943, PubMed:34628357). Responsible for the transport of estrone 3-sulfate (E1S) through the basal membrane of syncytiotrophoblast, highlighting a potential role in the placental absorption of fetal-derived sulfated steroids including the steroid hormone precursor dehydroepiandrosterone sulfate (DHEA-S) (PubMed:11932330, PubMed:12409283). Also facilitates the uptake of sulfated steroids at the basal/sinusoidal membrane of hepatocytes, therefore accounting for the major part of organic anions clearance of liver (PubMed:11159893). Mediates the intestinal uptake of sulfated steroids (PubMed:12724351, PubMed:28408210). Mediates the uptake of the neurosteroids DHEA-S and pregnenolone sulfate (PregS) into the endothelial cells of the blood-brain barrier as the first step to enter the brain (PubMed:16908597, PubMed:25132355). Also plays a role in the reuptake of neuropeptides such as substance P/TAC1 and vasoactive intestinal peptide/VIP released from retinal neurons (PubMed:25132355). May act as a heme transporter that promotes cellular iron availability via heme oxygenase/HMOX2 and independently of TFRC (PubMed:35714613). Also transports heme by-product coproporphyrin III (CPIII), and may be involved in their hepatic disposition (PubMed:26383540). Mediates the uptake of other substrates such as prostaglandins D2 (PGD2), E1 (PGE1) and E2 (PGE2), taurocholate, L-thyroxine, leukotriene C4 and thromboxane B2 (PubMed:10873595, PubMed:14610227, PubMed:19129463, PubMed:29871943, Ref.25). May contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (Probable). Shows a pH-sensitive substrate specificity which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment (PubMed:14610227, PubMed:19129463, PubMed:22201122). The exact transport mechanism has not been yet deciphered but most likely involves an anion exchange, coupling the cellular uptake of organic substrate with the efflux of an anionic compound (PubMed:19129463, PubMed:20507927, PubMed:26277985). Hydrogencarbonate/HCO3(-) acts as a probable counteranion that exchanges for organic anions (PubMed:19129463). Cytoplasmic glutamate may also act as counteranion in the placenta (PubMed:26277985). An inwardly directed proton gradient has also been proposed as the driving force of E1S uptake with a (H(+):E1S) stoichiometry of (1:1) (PubMed:20507927). {ECO:0000269|PubMed:10873595, ECO:0000269|PubMed:11159893, ECO:0000269|PubMed:11932330, ECO:0000269|PubMed:12409283, ECO:0000269|PubMed:12724351, ECO:0000269|PubMed:14610227, ECO:0000269|PubMed:16908597, ECO:0000269|PubMed:18501590, ECO:0000269|PubMed:19129463, ECO:0000269|PubMed:20507927, ECO:0000269|PubMed:22201122, ECO:0000269|PubMed:23531488, ECO:0000269|PubMed:25132355, ECO:0000269|PubMed:26277985, ECO:0000269|PubMed:26383540, ECO:0000269|PubMed:27576593, ECO:0000269|PubMed:29871943, ECO:0000269|PubMed:34628357, ECO:0000269|PubMed:35714613, ECO:0000269|Ref.25, ECO:0000305|PubMed:35307651}.; FUNCTION: [Isoform 3]: Has estrone 3-sulfate (E1S) transport activity comparable with the full-length isoform 1. {ECO:0000269|PubMed:23531488}. |
| O95405 | ZFYVE9 | S306 | ochoa | Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Novel serine protease) (NSP) (Receptor activation anchor) (hSARA) (Smad anchor for receptor activation) | Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization. {ECO:0000269|PubMed:15356634, ECO:0000269|PubMed:9865696}. |
| O95466 | FMNL1 | S914 | ochoa | Formin-like protein 1 (CLL-associated antigen KW-13) (Leukocyte formin) | May play a role in the control of cell motility and survival of macrophages (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. {ECO:0000250, ECO:0000269|PubMed:21834987}. |
| O95613 | PCNT | S610 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| O95644 | NFATC1 | S117 | psp | Nuclear factor of activated T-cells, cytoplasmic 1 (NF-ATc1) (NFATc1) (NFAT transcription complex cytosolic component) (NF-ATc) (NFATc) | Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells (PubMed:10358178). Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function (By similarity). {ECO:0000250|UniProtKB:O88942, ECO:0000269|PubMed:10358178}. |
| O95789 | ZMYM6 | S730 | ochoa | Zinc finger MYM-type protein 6 (Transposon-derived Buster2 transposase-like protein) (Zinc finger protein 258) | Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}. |
| P02724 | GYPA | S130 | ochoa | Glycophorin-A (MN sialoglycoprotein) (PAS-2) (Sialoglycoprotein alpha) (CD antigen CD235a) | Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane (PubMed:35835865). Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane. {ECO:0000269|PubMed:10926825, ECO:0000269|PubMed:12813056, ECO:0000269|PubMed:14604989, ECO:0000269|PubMed:19438409, ECO:0000269|PubMed:35835865}.; FUNCTION: (Microbial infection) Appears to be a receptor for Hepatitis A virus (HAV). {ECO:0000269|PubMed:15331714}.; FUNCTION: (Microbial infection) Receptor for P.falciparum erythrocyte-binding antigen 175 (EBA-175); binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans. {ECO:0000269|PubMed:8009226}. |
| P04083 | ANXA1 | S143 | ochoa | Annexin A1 (Annexin I) (Annexin-1) (Calpactin II) (Calpactin-2) (Chromobindin-9) (Lipocortin I) (Phospholipase A2 inhibitory protein) (p35) [Cleaved into: Annexin Ac2-26] | Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity). {ECO:0000250|UniProtKB:P10107, ECO:0000250|UniProtKB:P19619, ECO:0000269|PubMed:17008549, ECO:0000269|PubMed:19625660, ECO:0000269|PubMed:2532504, ECO:0000269|PubMed:2936963, ECO:0000269|PubMed:8425544, ECO:0000269|PubMed:8557678}.; FUNCTION: [Annexin Ac2-26]: Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:15187149, PubMed:22879591, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Promotes resolution of inflammation and wound healing (PubMed:25664854). Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2 (PubMed:22879591). {ECO:0000269|PubMed:15187149, ECO:0000269|PubMed:22879591, ECO:0000269|PubMed:25664854}. |
| P05412 | JUN | S73 | ochoa|psp | Transcription factor Jun (Activator protein 1) (AP1) (Proto-oncogene c-Jun) (Transcription factor AP-1 subunit Jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39) | Transcription factor that recognizes and binds to the AP-1 consensus motif 5'-TGA[GC]TCA-3' (PubMed:10995748, PubMed:22083952). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to the AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing its transcriptional activity (By similarity). Together with FOSB, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway (PubMed:12618758). Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (PubMed:17210646). Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306). {ECO:0000250|UniProtKB:P05627, ECO:0000269|PubMed:10995748, ECO:0000269|PubMed:12618758, ECO:0000269|PubMed:17210646, ECO:0000269|PubMed:22083952, ECO:0000269|PubMed:24623306}.; FUNCTION: (Microbial infection) Upon Epstein-Barr virus (EBV) infection, binds to viral BZLF1 Z promoter and activates viral BZLF1 expression. {ECO:0000269|PubMed:31341047}. |
| P05787 | KRT8 | S74 | psp | Keratin, type II cytoskeletal 8 (Cytokeratin-8) (CK-8) (Keratin-8) (K8) (Type-II keratin Kb8) | Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. {ECO:0000269|PubMed:16000376}. |
| P08581 | MET | S966 | ochoa | Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met) | Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of neuronal precursors, angiogenesis and kidney formation. During skeletal muscle development, it is crucial for the migration of muscle progenitor cells and for the proliferation of secondary myoblasts (By similarity). In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Also promotes differentiation and proliferation of hematopoietic cells. May regulate cortical bone osteogenesis (By similarity). {ECO:0000250|UniProtKB:P16056}.; FUNCTION: (Microbial infection) Acts as a receptor for Listeria monocytogenes internalin InlB, mediating entry of the pathogen into cells. {ECO:0000269|PubMed:11081636, ECO:0000305|PubMed:17662939, ECO:0000305|PubMed:19900460}. |
| P13804 | ETFA | S140 | ochoa | Electron transfer flavoprotein subunit alpha, mitochondrial (Alpha-ETF) | Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase (PubMed:10356313, PubMed:15159392, PubMed:15975918, PubMed:27499296, PubMed:9334218). It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (PubMed:9334218). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism (PubMed:12815589, PubMed:1430199, PubMed:1882842). {ECO:0000269|PubMed:10356313, ECO:0000269|PubMed:12815589, ECO:0000269|PubMed:1430199, ECO:0000269|PubMed:15159392, ECO:0000269|PubMed:15975918, ECO:0000269|PubMed:27499296, ECO:0000269|PubMed:9334218, ECO:0000303|PubMed:17941859, ECO:0000305|PubMed:1882842}. |
| P16885 | PLCG2 | S443 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-gamma-2) (Phospholipase C-IV) (PLC-IV) (Phospholipase C-gamma-2) (PLC-gamma-2) | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling. {ECO:0000269|PubMed:23000145}. |
| P20248 | CCNA2 | S154 | psp | Cyclin-A2 (Cyclin-A) (Cyclin A) | Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. {ECO:0000269|PubMed:1312467}. |
| P21127 | CDK11B | S589 | ochoa | Cyclin-dependent kinase 11B (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 1) (CLK-1) (Cell division protein kinase 11B) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L1) (p58 CLK-1) | Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression. {ECO:0000269|PubMed:12501247, ECO:0000269|PubMed:12624090, ECO:0000269|PubMed:18216018, ECO:0000269|PubMed:2217177}. |
| P22314 | UBA1 | S793 | ochoa | Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1) | Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1447181, PubMed:1606621, PubMed:33108101). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334). {ECO:0000269|PubMed:1447181, ECO:0000269|PubMed:1606621, ECO:0000269|PubMed:22456334, ECO:0000269|PubMed:33108101}. |
| P22607 | FGFR3 | S408 | ochoa | Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) (CD antigen CD333) | Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Plays a role in the regulation of vitamin D metabolism. Mutations that lead to constitutive kinase activation or impair normal FGFR3 maturation, internalization and degradation lead to aberrant signaling. Over-expressed or constitutively activated FGFR3 promotes activation of PTPN11/SHP2, STAT1, STAT5A and STAT5B. Secreted isoform 3 retains its capacity to bind FGF1 and FGF2 and hence may interfere with FGF signaling. {ECO:0000269|PubMed:10611230, ECO:0000269|PubMed:11294897, ECO:0000269|PubMed:11703096, ECO:0000269|PubMed:14534538, ECO:0000269|PubMed:16410555, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17145761, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17509076, ECO:0000269|PubMed:17561467, ECO:0000269|PubMed:19088846, ECO:0000269|PubMed:19286672, ECO:0000269|PubMed:8663044}. |
| P23508 | MCC | S485 | ochoa | Colorectal mutant cancer protein (Protein MCC) | Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation (PubMed:18591935, PubMed:19555689, PubMed:22480440). Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity (PubMed:24824780). {ECO:0000269|PubMed:18591935, ECO:0000269|PubMed:19555689, ECO:0000269|PubMed:22480440, ECO:0000269|PubMed:24824780}. |
| P26038 | MSN | S74 | ochoa | Moesin (Membrane-organizing extension spike protein) | Ezrin-radixin-moesin (ERM) family protein that connects the actin cytoskeleton to the plasma membrane and thereby regulates the structure and function of specific domains of the cell cortex. Tethers actin filaments by oscillating between a resting and an activated state providing transient interactions between moesin and the actin cytoskeleton (PubMed:10212266). Once phosphorylated on its C-terminal threonine, moesin is activated leading to interaction with F-actin and cytoskeletal rearrangement (PubMed:10212266). These rearrangements regulate many cellular processes, including cell shape determination, membrane transport, and signal transduction (PubMed:12387735, PubMed:15039356). The role of moesin is particularly important in immunity acting on both T and B-cells homeostasis and self-tolerance, regulating lymphocyte egress from lymphoid organs (PubMed:9298994, PubMed:9616160). Modulates phagolysosomal biogenesis in macrophages (By similarity). Also participates in immunologic synapse formation (PubMed:27405666). {ECO:0000250|UniProtKB:P26041, ECO:0000269|PubMed:10212266, ECO:0000269|PubMed:12387735, ECO:0000269|PubMed:15039356, ECO:0000269|PubMed:27405666, ECO:0000269|PubMed:9298994, ECO:0000269|PubMed:9616160}. |
| P26358 | DNMT1 | S954 | ochoa | DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT) | Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). Promotes tumor growth (PubMed:24623306). {ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18754681, ECO:0000269|PubMed:24623306}. |
| P27816 | MAP4 | S280 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P30307 | CDC25C | S122 | ochoa|psp | M-phase inducer phosphatase 3 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25C) | Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle (PubMed:8119945). When phosphorylated, highly effective in activating G2 cells into prophase (PubMed:8119945). Directly dephosphorylates CDK1 and activates its kinase activity (PubMed:8119945). {ECO:0000269|PubMed:8119945}. |
| P37198 | NUP62 | S408 | ochoa | Nuclear pore glycoprotein p62 (62 kDa nucleoporin) (Nucleoporin Nup62) | Essential component of the nuclear pore complex (PubMed:1915414). The N-terminal is probably involved in nucleocytoplasmic transport (PubMed:1915414). The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of p62 to the pore complex (PubMed:1915414, PubMed:24107630). Plays a role in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation and spindle orientation (PubMed:24107630). It might be involved in protein recruitment to the centrosome after nuclear breakdown (PubMed:24107630). {ECO:0000269|PubMed:1915414, ECO:0000269|PubMed:24107630}. |
| P42345 | MTOR | S567 | ochoa | Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin and FKBP12 target 1) (Rapamycin target protein 1) (Tyrosine-protein kinase mTOR) (EC 2.7.10.2) | Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals (PubMed:12087098, PubMed:12150925, PubMed:12150926, PubMed:12231510, PubMed:12718876, PubMed:14651849, PubMed:15268862, PubMed:15467718, PubMed:15545625, PubMed:15718470, PubMed:18497260, PubMed:18762023, PubMed:18925875, PubMed:20516213, PubMed:20537536, PubMed:21659604, PubMed:23429703, PubMed:23429704, PubMed:25799227, PubMed:26018084, PubMed:29150432, PubMed:29236692, PubMed:31112131, PubMed:31601708, PubMed:32561715, PubMed:34519269, PubMed:37751742). MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins (PubMed:15268862, PubMed:15467718, PubMed:17517883, PubMed:18372248, PubMed:18497260, PubMed:18925875, PubMed:20516213, PubMed:21576368, PubMed:21659604, PubMed:23429704, PubMed:30171069, PubMed:29236692, PubMed:37751742). Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2) (PubMed:15268862, PubMed:15467718, PubMed:18497260, PubMed:18925875, PubMed:20516213, PubMed:21576368, PubMed:21659604, PubMed:23429704, PubMed:29424687, PubMed:29567957, PubMed:35926713). In response to nutrients, growth factors or amino acids, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis (PubMed:12087098, PubMed:12150925, PubMed:12150926, PubMed:12231510, PubMed:12718876, PubMed:14651849, PubMed:15268862, PubMed:15467718, PubMed:15545625, PubMed:15718470, PubMed:18497260, PubMed:18762023, PubMed:18925875, PubMed:20516213, PubMed:20537536, PubMed:21659604, PubMed:23429703, PubMed:23429704, PubMed:25799227, PubMed:26018084, PubMed:29150432, PubMed:29236692, PubMed:31112131, PubMed:34519269). This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E) (PubMed:24403073, PubMed:29236692). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4 (PubMed:12087098, PubMed:12150925, PubMed:18925875, PubMed:29150432, PubMed:29236692). Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation, through transcriptional enhancement of the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex (PubMed:23429703, PubMed:23429704). Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor (PubMed:20516213). Activates dormant ribosomes by mediating phosphorylation of SERBP1, leading to SERBP1 inactivation and reactivation of translation (PubMed:36691768). In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1 (PubMed:23426360). To maintain energy homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A (By similarity). In the same time, mTORC1 inhibits catabolic pathways: negatively regulates autophagy through phosphorylation of ULK1 (PubMed:32561715). Under nutrient sufficiency, phosphorylates ULK1 at 'Ser-758', disrupting the interaction with AMPK and preventing activation of ULK1 (PubMed:32561715). Also prevents autophagy through phosphorylation of the autophagy inhibitor DAP (PubMed:20537536). Also prevents autophagy by phosphorylating RUBCNL/Pacer under nutrient-rich conditions (PubMed:30704899). Prevents autophagy by mediating phosphorylation of AMBRA1, thereby inhibiting AMBRA1 ability to mediate ubiquitination of ULK1 and interaction between AMBRA1 and PPP2CA (PubMed:23524951, PubMed:25438055). mTORC1 exerts a feedback control on upstream growth factor signaling that includes phosphorylation and activation of GRB10 a INSR-dependent signaling suppressor (PubMed:21659604). Among other potential targets mTORC1 may phosphorylate CLIP1 and regulate microtubules (PubMed:12231510). The mTORC1 complex is inhibited in response to starvation and amino acid depletion (PubMed:12150925, PubMed:12150926, PubMed:24403073, PubMed:31695197). The non-canonical mTORC1 complex, which acts independently of RHEB, specifically mediates phosphorylation of MiT/TFE factors MITF, TFEB and TFE3 in the presence of nutrients, promoting their cytosolic retention and inactivation (PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:24448649, PubMed:32612235, PubMed:36608670, PubMed:36697823). Upon starvation or lysosomal stress, inhibition of mTORC1 induces dephosphorylation and nuclear translocation of TFEB and TFE3, promoting their transcription factor activity (PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:24448649, PubMed:32612235, PubMed:36608670). The mTORC1 complex regulates pyroptosis in macrophages by promoting GSDMD oligomerization (PubMed:34289345). MTOR phosphorylates RPTOR which in turn inhibits mTORC1 (By similarity). As part of the mTORC2 complex, MTOR transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15268862, PubMed:15467718, PubMed:24670654, PubMed:29424687, PubMed:29567957, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:15268862, PubMed:15467718, PubMed:21376236, PubMed:24670654, PubMed:29424687, PubMed:29567957, PubMed:35926713). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:15467718). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:15718470, PubMed:21376236, PubMed:24670654, PubMed:29424687, PubMed:29567957). mTORC2 also regulates the phosphorylation of SGK1 at 'Ser-422' (PubMed:18925875). mTORC2 may regulate the actin cytoskeleton, through phosphorylation of PRKCA, PXN and activation of the Rho-type guanine nucleotide exchange factors RHOA and RAC1A or RAC1B (PubMed:15268862). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). May also regulate insulin signaling by acting as a tyrosine protein kinase that catalyzes phosphorylation of IGF1R and INSR; additional evidence are however required to confirm this result in vivo (PubMed:26584640). Regulates osteoclastogenesis by adjusting the expression of CEBPB isoforms (By similarity). Plays an important regulatory role in the circadian clock function; regulates period length and rhythm amplitude of the suprachiasmatic nucleus (SCN) and liver clocks (By similarity). {ECO:0000250|UniProtKB:Q9JLN9, ECO:0000269|PubMed:12087098, ECO:0000269|PubMed:12150925, ECO:0000269|PubMed:12150926, ECO:0000269|PubMed:12231510, ECO:0000269|PubMed:12718876, ECO:0000269|PubMed:14651849, ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15545625, ECO:0000269|PubMed:15718470, ECO:0000269|PubMed:17517883, ECO:0000269|PubMed:18372248, ECO:0000269|PubMed:18497260, ECO:0000269|PubMed:18762023, ECO:0000269|PubMed:18925875, ECO:0000269|PubMed:20516213, ECO:0000269|PubMed:20537536, ECO:0000269|PubMed:21376236, ECO:0000269|PubMed:21576368, ECO:0000269|PubMed:21659604, ECO:0000269|PubMed:22343943, ECO:0000269|PubMed:22576015, ECO:0000269|PubMed:22692423, ECO:0000269|PubMed:23426360, ECO:0000269|PubMed:23429703, ECO:0000269|PubMed:23429704, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:24403073, ECO:0000269|PubMed:24448649, ECO:0000269|PubMed:24670654, ECO:0000269|PubMed:25438055, ECO:0000269|PubMed:25799227, ECO:0000269|PubMed:26018084, ECO:0000269|PubMed:26584640, ECO:0000269|PubMed:29150432, ECO:0000269|PubMed:29236692, ECO:0000269|PubMed:29424687, ECO:0000269|PubMed:29567957, ECO:0000269|PubMed:30171069, ECO:0000269|PubMed:30704899, ECO:0000269|PubMed:31112131, ECO:0000269|PubMed:31601708, ECO:0000269|PubMed:31695197, ECO:0000269|PubMed:32561715, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:34289345, ECO:0000269|PubMed:34519269, ECO:0000269|PubMed:35926713, ECO:0000269|PubMed:36608670, ECO:0000269|PubMed:36691768, ECO:0000269|PubMed:36697823, ECO:0000269|PubMed:37751742}. |
| P42684 | ABL2 | S936 | ochoa | Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson tyrosine-protein kinase 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG) | Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 also acts as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). {ECO:0000250|UniProtKB:Q4JIM5, ECO:0000269|PubMed:15735735, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:18945674}. |
| P46020 | PHKA1 | S735 | ochoa | Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform (Phosphorylase kinase alpha M subunit) | Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin. |
| P46940 | IQGAP1 | S648 | ochoa | Ras GTPase-activating-like protein IQGAP1 (p195) | Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Recruited to the cell cortex by interaction with ILK which allows it to cooperate with its effector DIAPH1 to locally stabilize microtubules and allow stable insertion of caveolae into the plasma membrane (By similarity). Binds to activated CDC42 but does not stimulate its GTPase activity. Associates with calmodulin. May promote neurite outgrowth (PubMed:15695813). May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest (PubMed:20883816). {ECO:0000250|UniProtKB:Q9JKF1, ECO:0000269|PubMed:15695813, ECO:0000269|PubMed:20883816}. |
| P48552 | NRIP1 | S518 | ochoa | Nuclear receptor-interacting protein 1 (Nuclear factor RIP140) (Receptor-interacting protein 140) | Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function (By similarity). Plays a role in renal development (PubMed:28381549). {ECO:0000250|UniProtKB:Q8CBD1, ECO:0000269|PubMed:10364267, ECO:0000269|PubMed:11509661, ECO:0000269|PubMed:11518808, ECO:0000269|PubMed:12554755, ECO:0000269|PubMed:15060175, ECO:0000269|PubMed:21628546, ECO:0000269|PubMed:28381549, ECO:0000269|PubMed:7641693}. |
| P48681 | NES | S680 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P49327 | FASN | S361 | ochoa | Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] | Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269|PubMed:16215233, ECO:0000269|PubMed:16969344, ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
| P49327 | FASN | S523 | ochoa | Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] | Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269|PubMed:16215233, ECO:0000269|PubMed:16969344, ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
| P49756 | RBM25 | S803 | ochoa | RNA-binding protein 25 (Arg/Glu/Asp-rich protein of 120 kDa) (RED120) (Protein S164) (RNA-binding motif protein 25) (RNA-binding region-containing protein 7) | RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA. Also involved in the generation of an abnormal and truncated splice form of SCN5A in heart failure. {ECO:0000269|PubMed:18663000, ECO:0000269|PubMed:21859973}. |
| P49796 | RGS3 | S401 | ochoa | Regulator of G-protein signaling 3 (RGP3) (RGS3) | Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases. {ECO:0000269|PubMed:10749886, ECO:0000269|PubMed:11294858, ECO:0000269|PubMed:8602223, ECO:0000269|PubMed:9858594}. |
| P49902 | NT5C2 | S408 | ochoa | Cytosolic purine 5'-nucleotidase (EC 3.1.3.5) (EC 3.1.3.99) (Cytosolic 5'-nucleotidase II) (cN-II) (Cytosolic IMP/GMP-specific 5'-nucleotidase) (Cytosolic nucleoside phosphotransferase 5'N) (EC 2.7.1.77) (High Km 5'-nucleotidase) | Broad specificity cytosolic 5'-nucleotidase that catalyzes the dephosphorylation of 6-hydroxypurine nucleoside 5'-monophosphates (PubMed:10092873, PubMed:12907246, PubMed:1659319, PubMed:9371705). In addition, possesses a phosphotransferase activity by which it can transfer a phosphate from a donor nucleoside monophosphate to an acceptor nucleoside, preferably inosine, deoxyinosine and guanosine (PubMed:1659319, PubMed:9371705). Has the highest activities for IMP and GMP followed by dIMP, dGMP and XMP (PubMed:10092873, PubMed:12907246, PubMed:1659319, PubMed:9371705). Could also catalyze the transfer of phosphates from pyrimidine monophosphates but with lower efficiency (PubMed:1659319, PubMed:9371705). Through these activities regulates the purine nucleoside/nucleotide pools within the cell (PubMed:10092873, PubMed:12907246, PubMed:1659319, PubMed:9371705). {ECO:0000269|PubMed:10092873, ECO:0000269|PubMed:12907246, ECO:0000269|PubMed:1659319, ECO:0000269|PubMed:9371705}. |
| P50613 | CDK7 | S164 | ochoa|psp | Cyclin-dependent kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (39 kDa protein kinase) (p39 Mo15) (CDK-activating kinase 1) (Cell division protein kinase 7) (Serine/threonine-protein kinase 1) (TFIIH basal transcription factor complex kinase subunit) | Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription (PubMed:9852112, PubMed:19136461, PubMed:26257281, PubMed:28768201). Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201). Initiates transcription by RNA polymerase II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, PubMed:28768201). CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the CTD of POLR2A, allowing its escape from the promoter and elongation of the transcripts (PubMed:9852112). Its expression and activity are constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 activation by phosphorylation, but is inactivated in turn by p53/TP53; this feedback loop may lead to an arrest of the cell cycle and of the transcription, helping in cell recovery, or to apoptosis. Required for DNA-bound peptides-mediated transcription and cellular growth inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, ECO:0000269|PubMed:9372954, ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| P50991 | CCT4 | S184 | ochoa | T-complex protein 1 subunit delta (TCP-1-delta) (EC 3.6.1.-) (CCT-delta) (Chaperonin containing T-complex polypeptide 1 subunit 4) (Stimulator of TAR RNA-binding) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P51814 | ZNF41 | S269 | ochoa | Zinc finger protein 41 | May be involved in transcriptional regulation. |
| P51955 | NEK2 | S377 | ochoa | Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (HSPK 21) (Never in mitosis A-related kinase 2) (NimA-related protein kinase 2) (NimA-like protein kinase 1) | Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. Phosphorylates: PPP1CC; SGO1; NECAB3 and NPM1. Essential for localization of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome. Phosphorylates CEP68 and CNTLN directly or indirectly (PubMed:24554434). NEK2-mediated phosphorylation of CEP68 promotes CEP68 dissociation from the centrosome and its degradation at the onset of mitosis (PubMed:25704143). Involved in the regulation of centrosome disjunction (PubMed:26220856). Phosphorylates CCDC102B either directly or indirectly which causes CCDC102B to dissociate from the centrosome and allows for centrosome separation (PubMed:30404835). {ECO:0000269|PubMed:11742531, ECO:0000269|PubMed:12857871, ECO:0000269|PubMed:14978040, ECO:0000269|PubMed:15358203, ECO:0000269|PubMed:15388344, ECO:0000269|PubMed:17283141, ECO:0000269|PubMed:17621308, ECO:0000269|PubMed:17626005, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18297113, ECO:0000269|PubMed:20034488, ECO:0000269|PubMed:21076410, ECO:0000269|PubMed:24554434, ECO:0000269|PubMed:25704143, ECO:0000269|PubMed:26220856, ECO:0000269|PubMed:30404835}.; FUNCTION: [Isoform 1]: Phosphorylates and activates NEK11 in G1/S-arrested cells. {ECO:0000269|PubMed:15161910}.; FUNCTION: [Isoform 2]: Not present in the nucleolus and, in contrast to isoform 1, does not phosphorylate and activate NEK11 in G1/S-arrested cells. {ECO:0000269|PubMed:15161910}. |
| P51957 | NEK4 | S340 | ochoa | Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) | Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage. {ECO:0000250|UniProtKB:Q9Z1J2, ECO:0000269|PubMed:22851694}. |
| P51957 | NEK4 | S484 | ochoa | Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) | Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage. {ECO:0000250|UniProtKB:Q9Z1J2, ECO:0000269|PubMed:22851694}. |
| P52790 | HK3 | S67 | ochoa | Hexokinase-3 (EC 2.7.1.1) (Hexokinase type III) (HK III) (Hexokinase-C) | Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively) (PubMed:8717435). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:8717435). {ECO:0000269|PubMed:8717435}. |
| P53992 | SEC24C | S862 | ochoa | Protein transport protein Sec24C (SEC24-related protein C) | Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:10214955, PubMed:17499046, PubMed:18843296, PubMed:20427317). Plays a central role in cargo selection within the COPII complex and together with SEC24D may have a different specificity compared to SEC24A and SEC24B (PubMed:17499046, PubMed:18843296, PubMed:20427317). May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed:20427317). May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed:18843296). {ECO:0000269|PubMed:10214955, ECO:0000269|PubMed:17499046, ECO:0000269|PubMed:18843296, ECO:0000269|PubMed:20427317}. |
| P78347 | GTF2I | S668 | ochoa | General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BAP-135) (BTK-associated protein 135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosomal region 6 protein) | Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. {ECO:0000269|PubMed:10373551, ECO:0000269|PubMed:11373296, ECO:0000269|PubMed:16738337}. |
| P98088 | MUC5AC | S988 | ochoa | Mucin-5AC (MUC-5AC) (Gastric mucin) (Major airway glycoprotein) (Mucin-5 subtype AC, tracheobronchial) (Tracheobronchial mucin) (TBM) | Gel-forming glycoprotein of gastric and respiratory tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microorganisms and particles that are subsequently removed by the mucociliary system (PubMed:14535999, PubMed:14718370). Interacts with H.pylori in the gastric epithelium, Barrett's esophagus as well as in gastric metaplasia of the duodenum (GMD) (PubMed:14535999). {ECO:0000269|PubMed:14535999, ECO:0000303|PubMed:14535999, ECO:0000303|PubMed:14718370}. |
| P98160 | HSPG2 | S4277 | ochoa | Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG) (Perlecan) (PLC) [Cleaved into: Endorepellin; LG3 peptide] | Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development.; FUNCTION: [Endorepellin]: Anti-angiogenic and anti-tumor peptide that inhibits endothelial cell migration, collagen-induced endothelial tube morphogenesis and blood vessel growth in the chorioallantoic membrane. Blocks endothelial cell adhesion to fibronectin and type I collagen. Anti-tumor agent in neovascularization. Interaction with its ligand, integrin alpha2/beta1, is required for the anti-angiogenic properties. Evokes a reduction in phosphorylation of receptor tyrosine kinases via alpha2/beta1 integrin-mediated activation of the tyrosine phosphatase, PTPN6.; FUNCTION: [LG3 peptide]: Has anti-angiogenic properties that require binding of calcium ions for full activity. |
| Q03001 | DST | S1382 | ochoa | Dystonin (230 kDa bullous pemphigoid antigen) (230/240 kDa bullous pemphigoid antigen) (Bullous pemphigoid antigen 1) (BPA) (Bullous pemphigoid antigen) (Dystonia musculorum protein) (Hemidesmosomal plaque protein) | Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1 (By similarity). {ECO:0000250|UniProtKB:Q91ZU6}.; FUNCTION: [Isoform 3]: Plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity.; FUNCTION: [Isoform 6]: Required for bundling actin filaments around the nucleus. {ECO:0000250, ECO:0000269|PubMed:10428034, ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692}.; FUNCTION: [Isoform 7]: Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. |
| Q06187 | BTK | S371 | ochoa | Tyrosine-protein kinase BTK (EC 2.7.10.2) (Agammaglobulinemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Bruton tyrosine kinase) | Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling (PubMed:19290921). Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation (PubMed:19290921). After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members (PubMed:11606584). PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK (PubMed:11606584). BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways (PubMed:16517732, PubMed:17932028). Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway (PubMed:16517732). The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense (PubMed:16517732). Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells (PubMed:16517732, PubMed:17932028). Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation (PubMed:16415872). BTK also plays a critical role in transcription regulation (PubMed:19290921). Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes (PubMed:19290921). BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B (PubMed:19290921). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (PubMed:34554188). Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR (PubMed:9012831). GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression (PubMed:9012831). ARID3A and NFAT are other transcriptional target of BTK (PubMed:16738337). BTK is required for the formation of functional ARID3A DNA-binding complexes (PubMed:16738337). There is however no evidence that BTK itself binds directly to DNA (PubMed:16738337). BTK has a dual role in the regulation of apoptosis (PubMed:9751072). Plays a role in STING1-mediated induction of type I interferon (IFN) response by phosphorylating DDX41 (PubMed:25704810). {ECO:0000269|PubMed:11606584, ECO:0000269|PubMed:16415872, ECO:0000269|PubMed:16517732, ECO:0000269|PubMed:16738337, ECO:0000269|PubMed:17932028, ECO:0000269|PubMed:25704810, ECO:0000269|PubMed:34554188, ECO:0000269|PubMed:9012831, ECO:0000303|PubMed:19290921, ECO:0000303|PubMed:9751072}. |
| Q07869 | PPARA | S21 | psp | Peroxisome proliferator-activated receptor alpha (PPAR-alpha) (Nuclear receptor subfamily 1 group C member 1) | Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as a transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2. {ECO:0000269|PubMed:10195690, ECO:0000269|PubMed:24043310, ECO:0000269|PubMed:7629123, ECO:0000269|PubMed:7684926, ECO:0000269|PubMed:9556573}. |
| Q08050 | FOXM1 | S672 | ochoa|psp | Forkhead box protein M1 (Forkhead-related protein FKHL16) (Hepatocyte nuclear factor 3 forkhead homolog 11) (HFH-11) (HNF-3/fork-head homolog 11) (M-phase phosphoprotein 2) (MPM-2 reactive phosphoprotein 2) (Transcription factor Trident) (Winged-helix factor from INS-1 cells) | Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis (PubMed:19160488, PubMed:20360045). Plays a role in the control of cell proliferation (PubMed:19160488). Also plays a role in DNA break repair, participating in the DNA damage checkpoint response (PubMed:17101782). Promotes transcription of PHB2 (PubMed:33754036). {ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:19160488, ECO:0000269|PubMed:20360045, ECO:0000269|PubMed:33754036}. |
| Q12772 | SREBF2 | S432 | psp | Sterol regulatory element-binding protein 2 (SREBP-2) (Class D basic helix-loop-helix protein 2) (bHLHd2) (Sterol regulatory element-binding transcription factor 2) [Cleaved into: Processed sterol regulatory element-binding protein 2 (Transcription factor SREBF2)] | [Sterol regulatory element-binding protein 2]: Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 2), which is embedded in the endoplasmic reticulum membrane (PubMed:32322062). Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis (PubMed:32322062). {ECO:0000269|PubMed:32322062}.; FUNCTION: [Processed sterol regulatory element-binding protein 2]: Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis (PubMed:12177166, PubMed:32322062). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3') (PubMed:12177166, PubMed:7903453). Regulates transcription of genes related to cholesterol synthesis pathway (PubMed:12177166, PubMed:32322062). {ECO:0000269|PubMed:12177166, ECO:0000269|PubMed:32322062, ECO:0000269|PubMed:7903453}. |
| Q12815 | TROAP | S213 | ochoa | Tastin (Trophinin-assisting protein) (Trophinin-associated protein) | Could be involved with bystin and trophinin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation. |
| Q12851 | MAP4K2 | S394 | ochoa | Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (B lymphocyte serine/threonine-protein kinase) (Germinal center kinase) (GC kinase) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Rab8-interacting protein) | Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway and to a lesser extent of the p38 MAPKs signaling pathway. Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including pathogen-associated molecular patterns (PAMPs) such as polyinosine-polycytidine (poly(IC)), lipopolysaccharides (LPS), lipid A, peptidoglycan (PGN), or bacterial flagellin. To a lesser degree, IL-1 and engagement of CD40 also stimulate MAP4K2-mediated JNKs activation. The requirement for MAP4K2/GCK is most pronounced for LPS signaling, and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8. Enhances MAP3K1 oligomerization, which may relieve N-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. Also mediates the SAP/JNK signaling pathway and the p38 MAPKs signaling pathway through activation of the MAP3Ks MAP3K10/MLK2 and MAP3K11/MLK3. May play a role in the regulation of vesicle targeting or fusion. regulation of vesicle targeting or fusion. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:11784851, ECO:0000269|PubMed:15456887, ECO:0000269|PubMed:17584736, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:7477268, ECO:0000269|PubMed:7515885, ECO:0000269|PubMed:9712898}. |
| Q13263 | TRIM28 | S697 | ochoa | Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28) | Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also a corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:Q62318, ECO:0000269|PubMed:10347202, ECO:0000269|PubMed:11959841, ECO:0000269|PubMed:15882967, ECO:0000269|PubMed:16107876, ECO:0000269|PubMed:16862143, ECO:0000269|PubMed:17079232, ECO:0000269|PubMed:17178852, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17942393, ECO:0000269|PubMed:18060868, ECO:0000269|PubMed:18082607, ECO:0000269|PubMed:20424263, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:21940674, ECO:0000269|PubMed:23543754, ECO:0000269|PubMed:23665872, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:8769649, ECO:0000269|PubMed:9016654}.; FUNCTION: (Microbial infection) Plays a critical role in the shutdown of lytic gene expression during the early stage of herpes virus 8 primary infection. This inhibition is mediated through interaction with herpes virus 8 protein LANA1. {ECO:0000269|PubMed:24741090}. |
| Q13469 | NFATC2 | S148 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1) | Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF (PubMed:15790681). Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway (PubMed:21871017). Is involved in the negative regulation of chondrogenesis (PubMed:35789258). Recruited by AKAP5 to ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where store-operated Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses. {ECO:0000250|UniProtKB:Q60591, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:21871017, ECO:0000269|PubMed:35789258}. |
| Q13506 | NAB1 | S407 | ochoa | NGFI-A-binding protein 1 (EGR-1-binding protein 1) (Transcriptional regulatory protein p54) | Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. {ECO:0000250}. |
| Q147X3 | NAA30 | S199 | ochoa | N-alpha-acetyltransferase 30 (EC 2.3.1.256) (N-acetyltransferase 12) (N-acetyltransferase MAK3 homolog) (NatC catalytic subunit) | Catalytic subunit of the N-terminal acetyltransferase C (NatC) complex (PubMed:19398576, PubMed:37891180). Catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Leu-Ala and Met-Leu-Gly (PubMed:19398576, PubMed:37891180). N-terminal acetylation protects proteins from ubiquitination and degradation by the N-end rule pathway (PubMed:37891180). Necessary for the lysosomal localization and function of ARL8B sugeesting that ARL8B is a NatC substrate (PubMed:19398576). {ECO:0000269|PubMed:19398576, ECO:0000269|PubMed:37891180}. |
| Q14974 | KPNB1 | S683 | ochoa | Importin subunit beta-1 (Importin-90) (Karyopherin subunit beta-1) (Nuclear factor p97) (Pore targeting complex 97 kDa subunit) (PTAC97) | Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor (PubMed:10228156, PubMed:11682607, PubMed:11891849, PubMed:19386897, PubMed:20818336, PubMed:24699649, PubMed:7615630, PubMed:9687515). Acting autonomously, serves itself as NLS receptor (PubMed:10228156, PubMed:11682607, PubMed:11891849, PubMed:19386897, PubMed:20818336, PubMed:24699649, PubMed:7615630, PubMed:9687515). Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:10228156, PubMed:11682607, PubMed:11891849, PubMed:19386897, PubMed:20818336, PubMed:24699649, PubMed:7615630, PubMed:9687515). At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin (PubMed:10228156, PubMed:11682607, PubMed:11891849, PubMed:19386897, PubMed:20818336, PubMed:24699649, PubMed:7615630, PubMed:9687515). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:10228156, PubMed:11682607, PubMed:11891849, PubMed:19386897, PubMed:24699649, PubMed:7615630, PubMed:9687515). Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5 (PubMed:11682607, PubMed:9687515). In association with IPO7, mediates the nuclear import of H1 histone (PubMed:10228156). In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones (By similarity). Imports MRTFA, SNAI1 and PRKCI into the nucleus (PubMed:11891849, PubMed:19386897, PubMed:20818336, PubMed:24699649). {ECO:0000250|UniProtKB:P70168, ECO:0000269|PubMed:10228156, ECO:0000269|PubMed:11682607, ECO:0000269|PubMed:11891849, ECO:0000269|PubMed:19386897, ECO:0000269|PubMed:20818336, ECO:0000269|PubMed:24699649, ECO:0000269|PubMed:7615630, ECO:0000269|PubMed:9687515}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. {ECO:0000269|PubMed:16704975, ECO:0000269|PubMed:9405152, ECO:0000269|PubMed:9891055}. |
| Q15061 | WDR43 | S85 | ochoa | WD repeat-containing protein 43 (U3 small nucleolar RNA-associated protein 5 homolog) | Ribosome biogenesis factor that coordinates hyperactive transcription and ribogenesis (PubMed:17699751). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I (PubMed:17699751, PubMed:34516797). Essential for stem cell pluripotency and embryonic development. In the nucleoplasm, recruited by promoter-associated/nascent transcripts and transcription to active promoters where it facilitates releases of elongation factor P-TEFb and paused RNA polymerase II to allow transcription elongation and maintain high-level expression of its targets genes (By similarity). {ECO:0000250|UniProtKB:Q6ZQL4, ECO:0000269|PubMed:17699751, ECO:0000269|PubMed:34516797}. |
| Q15149 | PLEC | S754 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q15468 | STIL | S475 | ochoa | SCL-interrupting locus protein (TAL-1-interrupting locus protein) | Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1 (PubMed:16024801, PubMed:9372240). Plays an important role in the regulation of centriole duplication. Required for the onset of procentriole formation and proper mitotic progression. During procentriole formation, is essential for the correct loading of SASS6 and CPAP to the base of the procentriole to initiate procentriole assembly (PubMed:22020124). In complex with STIL acts as a modulator of PLK4-driven cytoskeletal rearrangements and directional cell motility (PubMed:29712910, PubMed:32107292). {ECO:0000269|PubMed:16024801, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:29712910, ECO:0000269|PubMed:32107292, ECO:0000269|PubMed:9372240}. |
| Q15468 | STIL | S1111 | ochoa | SCL-interrupting locus protein (TAL-1-interrupting locus protein) | Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1 (PubMed:16024801, PubMed:9372240). Plays an important role in the regulation of centriole duplication. Required for the onset of procentriole formation and proper mitotic progression. During procentriole formation, is essential for the correct loading of SASS6 and CPAP to the base of the procentriole to initiate procentriole assembly (PubMed:22020124). In complex with STIL acts as a modulator of PLK4-driven cytoskeletal rearrangements and directional cell motility (PubMed:29712910, PubMed:32107292). {ECO:0000269|PubMed:16024801, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:29712910, ECO:0000269|PubMed:32107292, ECO:0000269|PubMed:9372240}. |
| Q15599 | NHERF2 | S167 | ochoa | Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (NHE3 kinase A regulatory protein E3KARP) (SRY-interacting protein 1) (SIP-1) (Sodium-hydrogen exchanger regulatory factor 2) (Solute carrier family 9 isoform A3 regulatory factor 2) (Tyrosine kinase activator protein 1) (TKA-1) | Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3 (PubMed:18829453). May also act as scaffold protein in the nucleus. {ECO:0000269|PubMed:10455146, ECO:0000269|PubMed:18829453, ECO:0000269|PubMed:9096337}. |
| Q15742 | NAB2 | S479 | ochoa | NGFI-A-binding protein 2 (EGR-1-binding protein 2) (Melanoma-associated delayed early response protein) (Protein MADER) | Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity). {ECO:0000250}. |
| Q16600 | ZNF239 | S38 | ochoa | Zinc finger protein 239 (Zinc finger protein HOK-2) (Zinc finger protein MOK-2) | May be involved in transcriptional regulation. |
| Q29RF7 | PDS5A | S793 | ochoa | Sister chromatid cohesion protein PDS5 homolog A (Cell proliferation-inducing gene 54 protein) (Sister chromatid cohesion protein 112) (SCC-112) | Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15855230, ECO:0000269|PubMed:19907496}. |
| Q53GG5 | PDLIM3 | S89 | ochoa | PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha-actinin-2-associated LIM protein) | May play a role in the organization of actin filament arrays within muscle cells. {ECO:0000250}. |
| Q5JRA6 | MIA3 | S288 | ochoa | Transport and Golgi organization protein 1 homolog (TANGO1) (C219-reactive peptide) (D320) (Melanoma inhibitory activity protein 3) | Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum (PubMed:19269366, PubMed:27138255). Required for correct assembly of COPII coat components at endoplasmic reticulum exit sites (ERES) and for the localization of SEC16A and membrane-bound ER-resident complexes consisting of MIA2 and PREB/SEC12 to ERES (PubMed:28442536). {ECO:0000269|PubMed:19269366, ECO:0000269|PubMed:27138255, ECO:0000269|PubMed:28442536}. |
| Q5VUA4 | ZNF318 | S1907 | ochoa | Zinc finger protein 318 (Endocrine regulatory protein) | [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}. |
| Q5VUA4 | ZNF318 | S2189 | ochoa | Zinc finger protein 318 (Endocrine regulatory protein) | [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}. |
| Q5VWQ8 | DAB2IP | S1168 | ochoa | Disabled homolog 2-interacting protein (DAB2 interaction protein) (DAB2-interacting protein) (ASK-interacting protein 1) (AIP-1) (DOC-2/DAB-2 interactive protein) | Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Involved in several processes such as innate immune response, inflammation and cell growth inhibition, apoptosis, cell survival, angiogenesis, cell migration and maturation. Also plays a role in cell cycle checkpoint control; reduces G1 phase cyclin levels resulting in G0/G1 cell cycle arrest. Mediates signal transduction by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF), interferon (IFN) or lipopolysaccharide (LPS). Modulates the balance between phosphatidylinositol 3-kinase (PI3K)-AKT-mediated cell survival and apoptosis stimulated kinase (MAP3K5)-JNK signaling pathways; sequesters both AKT1 and MAP3K5 and counterbalances the activity of each kinase by modulating their phosphorylation status in response to pro-inflammatory stimuli. Acts as a regulator of the endoplasmic reticulum (ER) unfolded protein response (UPR) pathway; specifically involved in transduction of the ER stress-response to the JNK cascade through ERN1. Mediates TNF-alpha-induced apoptosis activation by facilitating dissociation of inhibitor 14-3-3 from MAP3K5; recruits the PP2A phosphatase complex which dephosphorylates MAP3K5 on 'Ser-966', leading to the dissociation of 13-3-3 proteins and activation of the MAP3K5-JNK signaling pathway in endothelial cells. Also mediates TNF/TRAF2-induced MAP3K5-JNK activation, while it inhibits CHUK-NF-kappa-B signaling. Acts a negative regulator in the IFN-gamma-mediated JAK-STAT signaling cascade by inhibiting smooth muscle cell (VSMCs) proliferation and intimal expansion, and thus, prevents graft arteriosclerosis (GA). Acts as a GTPase-activating protein (GAP) for the ADP ribosylation factor 6 (ARF6), Ras and RAB40C (PubMed:29156729). Promotes hydrolysis of the ARF6-bound GTP and thus, negatively regulates phosphatidylinositol 4,5-bisphosphate (PIP2)-dependent TLR4-TIRAP-MyD88 and NF-kappa-B signaling pathways in endothelial cells in response to lipopolysaccharides (LPS). Binds specifically to phosphatidylinositol 4-phosphate (PtdIns4P) and phosphatidylinositol 3-phosphate (PtdIns3P). In response to vascular endothelial growth factor (VEGFA), acts as a negative regulator of the VEGFR2-PI3K-mediated angiogenic signaling pathway by inhibiting endothelial cell migration and tube formation. In the developing brain, promotes both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex in a glial-dependent locomotion process. Probable downstream effector of the Reelin signaling pathway; promotes Purkinje cell (PC) dendrites development and formation of cerebellar synapses. Also functions as a tumor suppressor protein in prostate cancer progression; prevents cell proliferation and epithelial-to-mesenchymal transition (EMT) through activation of the glycogen synthase kinase-3 beta (GSK3B)-induced beta-catenin and inhibition of PI3K-AKT and Ras-MAPK survival downstream signaling cascades, respectively. {ECO:0000269|PubMed:12813029, ECO:0000269|PubMed:17389591, ECO:0000269|PubMed:18292600, ECO:0000269|PubMed:19033661, ECO:0000269|PubMed:19903888, ECO:0000269|PubMed:19948740, ECO:0000269|PubMed:20080667, ECO:0000269|PubMed:20154697, ECO:0000269|PubMed:21700930, ECO:0000269|PubMed:22696229, ECO:0000269|PubMed:29156729}. |
| Q63HR2 | TNS2 | S102 | ochoa | Tensin-2 (EC 3.1.3.48) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase) | Tyrosine-protein phosphatase which regulates cell motility, proliferation and muscle-response to insulin (PubMed:15817639, PubMed:23401856). Phosphatase activity is mediated by binding to phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3) via the SH2 domain (PubMed:30092354). In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy (PubMed:23401856, PubMed:30092354). Negatively regulates PI3K-AKT pathway activation (PubMed:15817639, PubMed:23401856, PubMed:30092354). Dephosphorylates nephrin NPHS1 in podocytes which regulates activity of the mTORC1 complex (PubMed:28955049). Under normal glucose conditions, NPHS1 outcompetes IRS1 for binding to phosphatidylinositol 3-kinase (PI3K) which balances mTORC1 activity but high glucose conditions lead to up-regulation of TNS2, increased NPHS1 dephosphorylation and activation of mTORC1, contributing to podocyte hypertrophy and proteinuria (PubMed:28955049). Required for correct podocyte morphology, podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in promoting DLC1-dependent remodeling of the extracellular matrix (PubMed:20069572). {ECO:0000250|UniProtKB:Q8CGB6, ECO:0000269|PubMed:15817639, ECO:0000269|PubMed:20069572, ECO:0000269|PubMed:23401856, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:28955049, ECO:0000269|PubMed:30092354}. |
| Q658Y4 | FAM91A1 | S340 | ochoa | Protein FAM91A1 | As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1. {ECO:0000269|PubMed:29426865}. |
| Q6DN90 | IQSEC1 | S515 | ochoa | IQ motif and SEC7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein) (BRAG2) | Guanine nucleotide exchange factor for ARF1 and ARF6 (PubMed:11226253, PubMed:24058294). Guanine nucleotide exchange factor activity is enhanced by lipid binding (PubMed:24058294). Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalization of beta-1 integrin (PubMed:16461286). Involved in neuronal development (Probable). In neurons, plays a role in the control of vesicle formation by endocytoc cargo. Upon long term depression, interacts with GRIA2 and mediates the activation of ARF6 to internalize synaptic AMPAR receptors (By similarity). {ECO:0000250|UniProtKB:A0A0G2JUG7, ECO:0000269|PubMed:11226253, ECO:0000269|PubMed:16461286, ECO:0000269|PubMed:24058294, ECO:0000305|PubMed:31607425}. |
| Q6IBS0 | TWF2 | S149 | ochoa | Twinfilin-2 (A6-related protein) (hA6RP) (Protein tyrosine kinase 9-like) (Twinfilin-1-like protein) | Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia (By similarity). {ECO:0000250}. |
| Q6L8Q7 | PDE12 | S442 | ochoa | 2',5'-phosphodiesterase 12 (2'-PDE) (2-PDE) (EC 3.1.4.-) (Mitochondrial deadenylase) (EC 3.1.13.4) | Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP (PubMed:26055709). Also cleaves 3',5'-phosphodiester bond of oligoadenylates (PubMed:21666256, PubMed:26055709, PubMed:30389976). Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured small-airway epithelial cells and Hela cells (PubMed:26055709). {ECO:0000269|PubMed:15231837, ECO:0000269|PubMed:21245038, ECO:0000269|PubMed:21666256, ECO:0000269|PubMed:22285541, ECO:0000269|PubMed:26055709, ECO:0000269|PubMed:30389976}. |
| Q6P4F7 | ARHGAP11A | S484 | ochoa | Rho GTPase-activating protein 11A (Rho-type GTPase-activating protein 11A) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000269|PubMed:27957544}. |
| Q6UB98 | ANKRD12 | S1401 | ochoa | Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein) | May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation. |
| Q6VMQ6 | ATF7IP | S57 | ochoa | Activating transcription factor 7-interacting protein 1 (ATF-interacting protein) (ATF-IP) (ATF7-interacting protein) (ATFa-associated modulator) (hAM) (MBD1-containing chromatin-associated factor 1) (P621) | Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing (PubMed:27732843). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1 (PubMed:12665582). Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (PubMed:14536086, PubMed:27732843). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells (PubMed:19106100). {ECO:0000269|PubMed:12665582, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:19106100, ECO:0000269|PubMed:27732843}. |
| Q6ZW49 | PAXIP1 | S332 | ochoa | PAX-interacting protein 1 (PAX transactivation activation domain-interacting protein) | Involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. Plays a role in early development. In DNA damage response is required for cell survival after ionizing radiation. In vitro shown to be involved in the homologous recombination mechanism for the repair of double-strand breaks (DSBs). Its localization to DNA damage foci requires RNF8 and UBE2N. Recruits TP53BP1 to DNA damage foci and, at least in particular repair processes, effective DNA damage response appears to require the association with TP53BP1 phosphorylated by ATM at 'Ser-25'. Together with TP53BP1 regulates ATM association. Proposed to recruit PAGR1 to sites of DNA damage and the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage; the function is probably independent of MLL-containing histone methyltransferase (HMT) complexes. However, this function has been questioned (By similarity). Promotes ubiquitination of PCNA following UV irradiation and may regulate recruitment of polymerase eta and RAD51 to chromatin after DNA damage. Proposed to be involved in transcriptional regulation by linking MLL-containing histone methyltransferase (HMT) complexes to gene promoters by interacting with promoter-bound transcription factors such as PAX2. Associates with gene promoters that are known to be regulated by KMT2D/MLL2. During immunoglobulin class switching in activated B-cells is involved in trimethylation of histone H3 at 'Lys-4' and in transcription initiation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus; this function appears to involve the recruitment of MLL-containing HMT complexes. Conflictingly, its function in transcriptional regulation during immunoglobulin class switching is reported to be independent of the MLL2/MLL3 complex (By similarity). {ECO:0000250|UniProtKB:Q6NZQ4, ECO:0000269|PubMed:14576432, ECO:0000269|PubMed:15456759, ECO:0000269|PubMed:17690115, ECO:0000269|PubMed:17925232, ECO:0000269|PubMed:18353733, ECO:0000269|PubMed:20088963, ECO:0000269|PubMed:23727112}. |
| Q71F56 | MED13L | S923 | ochoa | Mediator of RNA polymerase II transcription subunit 13-like (Mediator complex subunit 13-like) (Thyroid hormone receptor-associated protein 2) (Thyroid hormone receptor-associated protein complex 240 kDa component-like) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. |
| Q76N32 | CEP68 | S349 | ochoa | Centrosomal protein of 68 kDa (Cep68) | Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting (PubMed:18042621). Required for localization of CDK5RAP2 to the centrosome during interphase (PubMed:24554434, PubMed:25503564). Contributes to CROCC/rootletin filament formation (PubMed:30404835). {ECO:0000269|PubMed:18042621, ECO:0000269|PubMed:24554434, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:30404835}. |
| Q7L2J0 | MEPCE | S254 | ochoa | 7SK snRNA methylphosphate capping enzyme (MePCE) (EC 2.1.1.-) (Bicoid-interacting protein 3 homolog) (Bin3 homolog) | S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA), leading to stabilize it (PubMed:17643375, PubMed:19906723, PubMed:30559425). Also has a non-enzymatic function as part of the 7SK RNP complex: the 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:17643375). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate the assembly of 7SK RNP complex (PubMed:19906723, PubMed:38100593). MEPCE has a non-enzymatic function in the 7SK RNP complex; interaction with LARP7 within the 7SK RNP complex occluding its catalytic center (PubMed:19906723). Also required for stability of U6 snRNAs (PubMed:38100593). {ECO:0000269|PubMed:17643375, ECO:0000269|PubMed:19906723, ECO:0000269|PubMed:28254838, ECO:0000269|PubMed:30559425, ECO:0000269|PubMed:38100593}. |
| Q7Z333 | SETX | S1330 | ochoa | Probable helicase senataxin (EC 3.6.4.-) (Amyotrophic lateral sclerosis 4 protein) (SEN1 homolog) (Senataxin) | Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription (PubMed:19515850, PubMed:21700224). Contributes to the mRNA splicing efficiency and splice site selection (PubMed:19515850). Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (PubMed:19515850, PubMed:21700224, PubMed:26700805). Required for the 3' transcriptional termination of PER1 and CRY2, thus playing an important role in the circadian rhythm regulation (By similarity). Involved in DNA double-strand breaks damage response generated by oxidative stress (PubMed:17562789). In association with RRP45, targets the RNA exosome complex to sites of transcription-induced DNA damage (PubMed:24105744). Plays a role in the development and maturation of germ cells: essential for male meiosis, acting at the interface of transcription and meiotic recombination, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI) (By similarity). May be involved in telomeric stability through the regulation of telomere repeat-containing RNA (TERRA) transcription (PubMed:21112256). Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways. Inhibits retinoic acid-induced apoptosis (PubMed:21576111). {ECO:0000250|UniProtKB:A2AKX3, ECO:0000269|PubMed:17562789, ECO:0000269|PubMed:19515850, ECO:0000269|PubMed:21112256, ECO:0000269|PubMed:21576111, ECO:0000269|PubMed:21700224, ECO:0000269|PubMed:24105744, ECO:0000269|PubMed:26700805}. |
| Q7Z5Q1 | CPEB2 | S314 | ochoa | Cytoplasmic polyadenylation element-binding protein 2 (CPE-BP2) (CPE-binding protein 2) (hCPEB-2) | May play a role in translational regulation of stored mRNAs in transcriptionally inactive haploid spermatids. Binds to poly(U) RNA oligomers (By similarity). Required for cell cycle progression, specifically for the transition from metaphase to anaphase (PubMed:26398195). {ECO:0000250|UniProtKB:Q812E0, ECO:0000269|PubMed:26398195}. |
| Q7Z6Z7 | HUWE1 | S1218 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q86TC9 | MYPN | S101 | ochoa | Myopalladin (145 kDa sarcomeric protein) | Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines. {ECO:0000269|PubMed:11309420}. |
| Q86U86 | PBRM1 | S131 | ochoa | Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation. {ECO:0000269|PubMed:21248752, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q86UL8 | MAGI2 | S1014 | ochoa | Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Atrophin-1-interacting protein 1) (AIP-1) (Atrophin-1-interacting protein A) (Membrane-associated guanylate kinase inverted 2) (MAGI-2) | Seems to act as a scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins (By similarity). Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth (By similarity). May play a role in regulating activin-mediated signaling in neuronal cells (By similarity). Enhances the ability of PTEN to suppress AKT1 activation (PubMed:10760291). Plays a role in receptor-mediated clathrin-dependent endocytosis which is required for ciliogenesis (By similarity). {ECO:0000250|UniProtKB:O88382, ECO:0000250|UniProtKB:Q9WVQ1, ECO:0000269|PubMed:10760291}. |
| Q86YN6 | PPARGC1B | S524 | ochoa | Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PGC-1-beta) (PPAR-gamma coactivator 1-beta) (PPARGC-1-beta) (PGC-1-related estrogen receptor alpha coactivator) | Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. {ECO:0000269|PubMed:11854298, ECO:0000269|PubMed:12678921, ECO:0000269|PubMed:15546003, ECO:0000269|PubMed:23836911}. |
| Q8IUI4 | SNX29P2 | S191 | ochoa | Putative protein SNX29P2 (RUN domain-containing protein 2C) (Sorting nexin 29 protein pseudogene 2) | None |
| Q8IWT3 | CUL9 | S2436 | ochoa | Cullin-9 (CUL-9) (UbcH7-associated protein 1) (p53-associated parkin-like cytoplasmic protein) | Core component of a Cul9-RING ubiquitin-protein ligase complex composed of CUL9 and RBX1 (PubMed:38605244). The CUL9-RBX1 complex mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity. Acts downstream of the 3M complex, which inhibits the ubiquitination of BIRC5 (PubMed:24793696). The CUL9-RBX1 complex also mediates mono-ubiquitination of p53/TP53 (PubMed:38605244). Acts as a cytoplasmic anchor protein in p53/TP53-associated protein complex. Regulates the subcellular localization of p53/TP53 and its subsequent function (PubMed:12526791, PubMed:17332328). Ubiquitinates apurinic/apyrimidinic endodeoxyribonuclease APEX2 (PubMed:38605244). Ubiquitination by the CUL9-RBX1 complex is predominantly mediated by E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2D2 (PubMed:38605244). {ECO:0000269|PubMed:12526791, ECO:0000269|PubMed:17332328, ECO:0000269|PubMed:24793696, ECO:0000269|PubMed:38605244}. |
| Q8IXF0 | NPAS3 | S639 | ochoa | Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Basic-helix-loop-helix-PAS protein MOP6) (Class E basic helix-loop-helix protein 12) (bHLHe12) (Member of PAS protein 6) (PAS domain-containing protein 6) | May play a broad role in neurogenesis. May control regulatory pathways relevant to schizophrenia and to psychotic illness (By similarity). {ECO:0000250}. |
| Q8N3D4 | EHBP1L1 | S173 | ochoa | EH domain-binding protein 1-like protein 1 | May act as Rab effector protein and play a role in vesicle trafficking. {ECO:0000305|PubMed:27552051}. |
| Q8N468 | MFSD4A | S496 | ochoa | Major facilitator superfamily domain-containing protein 4A (Major facilitator superfamily domain-containing protein 4) | None |
| Q8N680 | ZBTB2 | S115 | psp | Zinc finger and BTB domain-containing protein 2 | May be involved in transcriptional regulation. |
| Q8N6H7 | ARFGAP2 | S146 | ochoa | ADP-ribosylation factor GTPase-activating protein 2 (ARF GAP 2) (GTPase-activating protein ZNF289) (Zinc finger protein 289) | GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. {ECO:0000269|PubMed:17760859}. |
| Q8NDI1 | EHBP1 | S174 | ochoa | EH domain-binding protein 1 | May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (PubMed:14676205, PubMed:27552051). Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). {ECO:0000250|UniProtKB:Q69ZW3, ECO:0000269|PubMed:14676205, ECO:0000305|PubMed:27552051}. |
| Q8NDI1 | EHBP1 | S710 | ochoa | EH domain-binding protein 1 | May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (PubMed:14676205, PubMed:27552051). Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). {ECO:0000250|UniProtKB:Q69ZW3, ECO:0000269|PubMed:14676205, ECO:0000305|PubMed:27552051}. |
| Q8NFW9 | MYRIP | S350 | ochoa | Rab effector MyRIP (Exophilin-8) (Myosin-VIIa- and Rab-interacting protein) (Synaptotagmin-like protein lacking C2 domains C) (SlaC2-c) (Slp homolog lacking C2 domains c) | Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments. Functions as a protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release (By similarity). {ECO:0000250}. |
| Q8TBM8 | DNAJB14 | S60 | ochoa | DnaJ homolog subfamily B member 14 | Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway (PubMed:24732912). Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities (PubMed:24732912). Can also act independently of HSPA8/Hsc70: together with DNAJB12, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers (PubMed:27916661). While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70 (PubMed:27916661). When overexpressed, forms membranous structures together with DNAJB12 and HSPA8/Hsc70 within the nucleus; the role of these structures, named DJANGOs, is still unclear (PubMed:24732912). {ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27916661}.; FUNCTION: (Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection (PubMed:21673190, PubMed:24675744). {ECO:0000269|PubMed:21673190, ECO:0000269|PubMed:24675744}. |
| Q8TDQ1 | CD300LF | S216 | psp | CMRF35-like molecule 1 (CLM-1) (CD300 antigen-like family member F) (Immune receptor expressed on myeloid cells 1) (IREM-1) (Immunoglobulin superfamily member 13) (IgSF13) (NK inhibitory receptor) (CD antigen CD300f) | Acts as an inhibitory receptor for myeloid cells and mast cells (PubMed:15549731). Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis (By similarity). Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide and sphingomyelin which act as ligands (PubMed:24035150). May act as a coreceptor for interleukin 4 (IL-4). Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling (By similarity). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:22043923). Inhibits osteoclast formation. Induces macrophage cell death upon engagement (By similarity). {ECO:0000250|UniProtKB:Q6SJQ7, ECO:0000269|PubMed:15549731, ECO:0000269|PubMed:22043923, ECO:0000269|PubMed:24035150}. |
| Q8TDW5 | SYTL5 | S147 | ochoa | Synaptotagmin-like protein 5 | May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids. |
| Q8TEM1 | NUP210 | S150 | ochoa | Nuclear pore membrane glycoprotein 210 (Nuclear pore protein gp210) (Nuclear envelope pore membrane protein POM 210) (POM210) (Nucleoporin Nup210) (Pore membrane protein of 210 kDa) | Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity. {ECO:0000269|PubMed:14517331}. |
| Q8TEQ0 | SNX29 | S344 | ochoa | Sorting nexin-29 (RUN domain-containing protein 2A) | None |
| Q8TF72 | SHROOM3 | S425 | ochoa | Protein Shroom3 (Shroom-related protein) (hShrmL) | Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}. |
| Q8WUF5 | PPP1R13L | S306 | ochoa | RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (NFkB-interacting protein 1) (PPP1R13B-like protein) | Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (PubMed:12524540). Is involved in NF-kappa-B dependent negative regulation of inflammatory response (PubMed:28069640). {ECO:0000269|PubMed:10336463, ECO:0000269|PubMed:12134007, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:15489900, ECO:0000269|PubMed:28069640}. |
| Q8WY91 | THAP4 | S410 | ochoa | Peroxynitrite isomerase THAP4 (EC 5.99.-.-) (Ferric Homo sapiens nitrobindin) (Hs-Nb(III)) (THAP domain-containing protein 4) | Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate. Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively). Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo, possibly modulating the transcriptional activity residing in the N-terminal region. {ECO:0000269|PubMed:30524950, ECO:0000269|PubMed:32295384}. |
| Q92574 | TSC1 | S332 | ochoa | Hamartin (Tuberous sclerosis 1 protein) | Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12906785, PubMed:15340059, PubMed:24529379, PubMed:28215400). The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12906785, PubMed:15340059, PubMed:24529379). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12271141, PubMed:24529379, PubMed:28215400, PubMed:33215753). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Within the TSC-TBC complex, TSC1 stabilizes TSC2 and prevents TSC2 self-aggregation (PubMed:10585443, PubMed:28215400). Acts as a tumor suppressor (PubMed:9242607). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 (PubMed:29127155). Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity (PubMed:29127155). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155). Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1 (PubMed:16464865, PubMed:29127155). {ECO:0000250|UniProtKB:Q9Z136, ECO:0000269|PubMed:10585443, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:16464865, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:29127155, ECO:0000269|PubMed:33215753, ECO:0000269|PubMed:9242607}. |
| Q92844 | TANK | S357 | ochoa | TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF) | Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989). Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989). May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. {ECO:0000269|PubMed:12133833, ECO:0000269|PubMed:21931631, ECO:0000269|PubMed:25861989}. |
| Q96AV8 | E2F7 | S95 | ochoa | Transcription factor E2F7 (E2F-7) | Atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Also involved in DNA damage response: up-regulated by p53/TP53 following genotoxic stress and acts as a downstream effector of p53/TP53-dependent repression by mediating repression of indirect p53/TP53 target genes involved in DNA replication. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. Acts as a negative regulator of keratinocyte differentiation. {ECO:0000269|PubMed:14633988, ECO:0000269|PubMed:15133492, ECO:0000269|PubMed:18202719, ECO:0000269|PubMed:19223542, ECO:0000269|PubMed:21248772, ECO:0000269|PubMed:22802528, ECO:0000269|PubMed:22802529, ECO:0000269|PubMed:22903062}. |
| Q96CC6 | RHBDF1 | S136 | ochoa | Inactive rhomboid protein 1 (iRhom1) (Epidermal growth factor receptor-related protein) (Rhomboid 5 homolog 1) (Rhomboid family member 1) (p100hRho) | Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. {ECO:0000269|PubMed:15965977, ECO:0000269|PubMed:18524845, ECO:0000269|PubMed:18832597, ECO:0000269|PubMed:21439629}. |
| Q96L73 | NSD1 | S571 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) | Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context. {ECO:0000269|PubMed:21196496}. |
| Q96L73 | NSD1 | S2623 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) | Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context. {ECO:0000269|PubMed:21196496}. |
| Q96N21 | TEPSIN | S333 | ochoa | AP-4 complex accessory subunit Tepsin (ENTH domain-containing protein 2) (Epsin for AP-4) (Tetra-epsin) | Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network. {ECO:0000305|PubMed:22472443, ECO:0000305|PubMed:26542808}. |
| Q96PE3 | INPP4A | S487 | ochoa | Inositol polyphosphate-4-phosphatase type I A (Inositol polyphosphate 4-phosphatase type I) (Type I inositol 3,4-bisphosphate 4-phosphatase) (EC 3.1.3.66) | Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) (PubMed:15716355, PubMed:20463662). Also catalyzes inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate (By similarity). Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (By similarity) (PubMed:30071275). May protect neurons from excitotoxic cell death by regulating the synaptic localization of cell surface N-methyl-D-aspartate-type glutamate receptors (NMDARs) and NMDAR-mediated excitatory postsynaptic current (By similarity). {ECO:0000250|UniProtKB:Q62784, ECO:0000250|UniProtKB:Q9EPW0, ECO:0000269|PubMed:15716355, ECO:0000269|PubMed:20463662, ECO:0000269|PubMed:30071275}.; FUNCTION: [Isoform 4]: Displays no 4-phosphatase activity for PtdIns(3,4)P2, Ins(3,4)P2, or Ins(1,3,4)P3. {ECO:0000269|PubMed:9295334}. |
| Q96S19 | METTL26 | S149 | ochoa | Methyltransferase-like 26 | None |
| Q96T17 | MAP7D2 | S650 | ochoa | MAP7 domain-containing protein 2 | Microtubule-stabilizing protein that plays a role in the control of cell motility and neurite outgrowth via direct binding to the microtubule (By similarity). Acts as a critical cofactor for kinesin transport. In the proximal axon, regulates kinesin-1 family members, KIF5A, KIF5B and KIF5C recruitment to microtubules and contributes to kinesin-1-mediated transport in the axons (By similarity). {ECO:0000250|UniProtKB:A2AG50, ECO:0000250|UniProtKB:D4A4L4}. |
| Q96TA1 | NIBAN2 | S427 | ochoa | Protein Niban 2 (Meg-3) (Melanoma invasion by ERK) (MINERVA) (Niban-like protein 1) (Protein FAM129B) | May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro. {ECO:0000269|PubMed:19362540, ECO:0000269|PubMed:21148485}. |
| Q99569 | PKP4 | S1135 | ochoa | Plakophilin-4 (p0071) | Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269|PubMed:17115030}. |
| Q99623 | PHB2 | S119 | ochoa | Prohibitin-2 (B-cell receptor-associated protein BAP37) (D-prohibitin) (Repressor of estrogen receptor activity) | Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors and sex steroid hormones in the nucleus. {ECO:0000269|PubMed:10359819, ECO:0000269|PubMed:11302691, ECO:0000269|PubMed:20959514, ECO:0000269|PubMed:24003225, ECO:0000269|PubMed:28017329, ECO:0000269|PubMed:31522117}.; FUNCTION: In the mitochondria, together with PHB, forms large ring complexes (prohibitin complexes) in the inner mitochondrial membrane (IMM) and functions as a chaperone protein that stabilizes mitochondrial respiratory enzymes and maintains mitochondrial integrity in the IMM, which is required for mitochondrial morphogenesis, neuronal survival, and normal lifespan (Probable). The prohibitin complex, with DNAJC19, regulates cardiolipin remodeling and the protein turnover of OMA1 in a cardiolipin-binding manner (By similarity). Also regulates cytochrome-c oxidase assembly (COX) and mitochondrial respiration (PubMed:11302691, PubMed:20959514). Binding to sphingoid 1-phosphate (SPP) modulates its regulator activity (PubMed:11302691, PubMed:20959514). Has a key role of mitophagy receptor involved in targeting mitochondria for autophagic degradation (PubMed:28017329). Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6 (PubMed:31522117). {ECO:0000250|UniProtKB:O35129, ECO:0000269|PubMed:11302691, ECO:0000269|PubMed:20959514, ECO:0000269|PubMed:28017329, ECO:0000269|PubMed:31522117, ECO:0000305|PubMed:25904163}.; FUNCTION: In the nucleus, serves as transcriptional co-regulator (Probable). Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity (By similarity). {ECO:0000250|UniProtKB:O35129, ECO:0000305|PubMed:25904163}.; FUNCTION: In the plasma membrane, is involved in IGFBP6-induced cell migration (PubMed:24003225). Cooperates with CD86 to mediate CD86-signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates. Upon CD40 engagement, required to activate NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity). {ECO:0000250|UniProtKB:O35129, ECO:0000269|PubMed:24003225}.; FUNCTION: (Microbial infection) Involved in human enterovirus 71/EV-71 infection by enhancing the autophagy mechanism during the infection. {ECO:0000269|PubMed:32276428}. |
| Q9BSJ8 | ESYT1 | S324 | ochoa | Extended synaptotagmin-1 (E-Syt1) (Membrane-bound C2 domain-containing protein) | Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels (PubMed:23791178, PubMed:24183667). Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane (PubMed:24183667). Acts as an inhibitor of ADGRD1 G-protein-coupled receptor activity in absence of cytosolic calcium (PubMed:38758649). Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). {ECO:0000250|UniProtKB:A0FGR8, ECO:0000269|PubMed:23791178, ECO:0000269|PubMed:24183667, ECO:0000269|PubMed:38758649}. |
| Q9BT22 | ALG1 | S242 | ochoa | Chitobiosyldiphosphodolichol beta-mannosyltransferase (EC 2.4.1.142) (Asparagine-linked glycosylation protein 1 homolog) (Beta-1,4-mannosyltransferase) (GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase) (GDP-mannose-dolichol diphosphochitobiose mannosyltransferase) (Mannosyltransferase-1) (MT-1) (hMat-1) | Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes, on the cytoplasmic face of the endoplasmic reticulum, the addition of the first mannose residues to the dolichol-linked oligosaccharide chain, to produce Man1GlcNAc(2)-PP-dolichol core oligosaccharide. Man1GlcNAc(2)-PP-dolichol is a substrate for ALG2, the following enzyme in the biosynthetic pathway. {ECO:0000269|PubMed:10704531, ECO:0000269|PubMed:14973778, ECO:0000269|PubMed:26931382}. |
| Q9BV36 | MLPH | S444 | ochoa | Melanophilin (Exophilin-3) (Slp homolog lacking C2 domains a) (SlaC2-a) (Synaptotagmin-like protein 2a) | Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A. {ECO:0000269|PubMed:12062444}. |
| Q9BXC9 | BBS2 | S365 | ochoa | BBSome complex member BBS2 (Bardet-Biedl syndrome 2 protein) | The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization. {ECO:0000269|PubMed:17574030, ECO:0000269|PubMed:22072986}. |
| Q9C0C2 | TNKS1BP1 | S178 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9C0H5 | ARHGAP39 | S644 | ochoa | Rho GTPase-activating protein 39 | None |
| Q9C0I3 | CCSER1 | S649 | ochoa | Serine-rich coiled-coil domain-containing protein 1 (Coiled-coil serine-rich protein 1) | None |
| Q9H0K1 | SIK2 | S512 | psp | Serine/threonine-protein kinase SIK2 (EC 2.7.11.1) (Qin-induced kinase) (Salt-inducible kinase 2) (SIK-2) (Serine/threonine-protein kinase SNF1-like kinase 2) | Serine/threonine-protein kinase that plays a role in many biological processes such as fatty acid oxidation, autophagy, immune response or glucose metabolism (PubMed:23322770, PubMed:26983400). Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators (PubMed:15454081). Phosphorylates EP300 and thus inhibits its histone acetyltransferase activity (PubMed:21084751, PubMed:26983400). In turn, regulates the DNA-binding ability of several transcription factors such as PPARA or MLXIPL (PubMed:21084751, PubMed:26983400). Also plays a role in thymic T-cell development (By similarity). {ECO:0000250|UniProtKB:Q8CFH6, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:21084751, ECO:0000269|PubMed:23322770, ECO:0000269|PubMed:26983400}. |
| Q9H3R0 | KDM4C | S198 | ochoa | Lysine-specific demethylase 4C (EC 1.14.11.66) (Gene amplified in squamous cell carcinoma 1 protein) (GASC-1 protein) (JmjC domain-containing histone demethylation protein 3C) (Jumonji domain-containing protein 2C) ([histone H3]-trimethyl-L-lysine(9) demethylase 4C) | Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. {ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:28262558}. |
| Q9H845 | ACAD9 | S461 | ochoa | Complex I assembly factor ACAD9, mitochondrial (Acyl-CoA dehydrogenase family member 9) (ACAD-9) (EC 1.3.8.-) | As part of the MCIA complex, primarily participates in the assembly of the mitochondrial complex I and therefore plays a role in oxidative phosphorylation (PubMed:20816094, PubMed:24158852, PubMed:32320651). This moonlighting protein also has a dehydrogenase activity toward a broad range of substrates with greater specificity for long-chain unsaturated acyl-CoAs (PubMed:12359260, PubMed:16020546, PubMed:21237683, PubMed:24158852). However, in vivo, it does not seem to play a primary role in fatty acid oxidation (PubMed:20816094, PubMed:24158852). In addition, the function in complex I assembly is independent of the dehydrogenase activity of the protein (PubMed:24158852). {ECO:0000269|PubMed:12359260, ECO:0000269|PubMed:16020546, ECO:0000269|PubMed:20816094, ECO:0000269|PubMed:21237683, ECO:0000269|PubMed:24158852, ECO:0000269|PubMed:32320651}. |
| Q9HAU0 | PLEKHA5 | S937 | ochoa | Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2) | None |
| Q9HAZ2 | PRDM16 | S549 | ochoa | Histone-lysine N-methyltransferase PRDM16 (EC 2.1.1.367) (PR domain zinc finger protein 16) (PR domain-containing protein 16) (Transcription factor MEL1) (MDS1/EVI1-like gene 1) | Binds DNA and functions as a transcriptional regulator (PubMed:12816872). Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation (By similarity). Likely to be one of the primary histone methyltransferases along with MECOM/PRDM3 that direct cytoplasmic H3K9me1 methylation (By similarity). Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism (By similarity). Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells (By similarity). Functions as a repressor of TGF-beta signaling (PubMed:19049980). {ECO:0000250|UniProtKB:A2A935, ECO:0000269|PubMed:12816872, ECO:0000269|PubMed:19049980}.; FUNCTION: [Isoform 4]: Binds DNA and functions as a transcriptional regulator (PubMed:12816872). Functions as a repressor of TGF-beta signaling (PubMed:14656887). May regulate granulocyte differentiation (PubMed:12816872). {ECO:0000269|PubMed:12816872, ECO:0000269|PubMed:14656887}. |
| Q9HCJ3 | RAVER2 | S598 | ochoa | Ribonucleoprotein PTB-binding 2 (Protein raver-2) | May bind single-stranded nucleic acids. {ECO:0000305}. |
| Q9NP74 | PALMD | S112 | ochoa | Palmdelphin (Paralemmin-like protein) | None |
| Q9NQW6 | ANLN | S792 | ochoa | Anillin | Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}. |
| Q9NRS6 | SNX15 | S227 | ochoa | Sorting nexin-15 | May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN. {ECO:0000269|PubMed:11085978}. |
| Q9NS73 | MBIP | S91 | ochoa | MAP3K12-binding inhibitory protein 1 (MAPK upstream kinase-binding inhibitory protein) (MUK-binding inhibitory protein) | Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. {ECO:0000269|PubMed:19103755}. |
| Q9NVC3 | SLC38A7 | S28 | ochoa | Sodium-coupled neutral amino acid transporter 7 (Solute carrier family 38 member 7) | Symporter that selectively cotransports sodium ions and amino acids, such as L-glutamine and L-asparagine from the lysosome into the cytoplasm and may participates in mTORC1 activation (PubMed:28416685, PubMed:35561222). The transport activity requires an acidic lysosomal lumen (PubMed:28416685). {ECO:0000269|PubMed:28416685, ECO:0000269|PubMed:35561222}. |
| Q9NWZ3 | IRAK4 | S114 | psp | Interleukin-1 receptor-associated kinase 4 (IRAK-4) (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-64) | Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways (PubMed:17878374). Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections. {ECO:0000269|PubMed:11960013, ECO:0000269|PubMed:12538665, ECO:0000269|PubMed:15084582, ECO:0000269|PubMed:17217339, ECO:0000269|PubMed:17337443, ECO:0000269|PubMed:17878374, ECO:0000269|PubMed:17997719, ECO:0000269|PubMed:20400509, ECO:0000269|PubMed:24316379}. |
| Q9P0L0 | VAPA | S216 | ochoa | Vesicle-associated membrane protein-associated protein A (VAMP-A) (VAMP-associated protein A) (VAP-A) (33 kDa VAMP-associated protein) (VAP-33) | Endoplasmic reticulum (ER)-anchored protein that mediates the formation of contact sites between the ER and endosomes via interaction with FFAT motif-containing proteins such as STARD3 or WDR44 (PubMed:32344433, PubMed:33124732). STARD3-VAPA interaction enables cholesterol transfer from the ER to endosomes (PubMed:33124732). Via interaction with WDR44 participates in neosynthesized protein export (PubMed:32344433). In addition, recruited to the plasma membrane through OSBPL3 binding (PubMed:25447204). The OSBPL3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:25447204). With OSBPL3, may regulate ER morphology (PubMed:16143324). May play a role in vesicle trafficking (PubMed:11511104, PubMed:19289470). {ECO:0000269|PubMed:11511104, ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:19289470, ECO:0000269|PubMed:25447204, ECO:0000269|PubMed:32344433, ECO:0000269|PubMed:33124732}. |
| Q9UBN7 | HDAC6 | S412 | psp | Protein deacetylase HDAC6 (EC 3.5.1.-) (E3 ubiquitin-protein ligase HDAC6) (EC 2.3.2.-) (Tubulin-lysine deacetylase HDAC6) (EC 3.5.1.-) | Deacetylates a wide range of non-histone substrates (PubMed:12024216, PubMed:18606987, PubMed:20308065, PubMed:24882211, PubMed:26246421, PubMed:30538141, PubMed:31857589, PubMed:30770470, PubMed:38534334, PubMed:39567688). Plays a central role in microtubule-dependent cell motility by mediating deacetylation of tubulin (PubMed:12024216, PubMed:20308065, PubMed:26246421). Required for cilia disassembly via deacetylation of alpha-tubulin (PubMed:17604723, PubMed:26246421). Alpha-tubulin deacetylation results in destabilization of dynamic microtubules (By similarity). Promotes deacetylation of CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy (PubMed:30538141). Deacetylates SQSTM1 (PubMed:31857589). Deacetylates peroxiredoxins PRDX1 and PRDX2, decreasing their reducing activity (PubMed:18606987). Deacetylates antiviral protein RIGI in the presence of viral mRNAs which is required for viral RNA detection by RIGI (By similarity). Sequentially deacetylates and polyubiquitinates DNA mismatch repair protein MSH2 which leads to MSH2 degradation, reducing cellular sensitivity to DNA-damaging agents and decreasing cellular DNA mismatch repair activities (PubMed:24882211). Deacetylates DNA mismatch repair protein MLH1 which prevents recruitment of the MutL alpha complex (formed by the MLH1-PMS2 heterodimer) to the MutS alpha complex (formed by the MSH2-MSH6 heterodimer), leading to tolerance of DNA damage (PubMed:30770470). Deacetylates RHOT1/MIRO1 which blocks mitochondrial transport and mediates axon growth inhibition (By similarity). Deacetylates transcription factor SP1 which leads to increased expression of ENG, positively regulating angiogenesis (PubMed:38534334). Deacetylates KHDRBS1/SAM68 which regulates alternative splicing by inhibiting the inclusion of CD44 alternate exons (PubMed:26080397). Acts as a valine sensor by binding to valine through the primate-specific SE14 repeat region (PubMed:39567688). In valine deprivation conditions, translocates from the cytoplasm to the nucleus where it deacetylates TET2 which promotes TET2-dependent DNA demethylation, leading to DNA damage (PubMed:39567688). Promotes odontoblast differentiation following IPO7-mediated nuclear import and subsequent repression of RUNX2 expression (By similarity). In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome (PubMed:17846173). Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and targets them to the aggresome, facilitating their clearance by autophagy (PubMed:17846173). Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer (PubMed:24413532). {ECO:0000250|UniProtKB:D3ZVD8, ECO:0000250|UniProtKB:Q9Z2V5, ECO:0000269|PubMed:12024216, ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:17846173, ECO:0000269|PubMed:18606987, ECO:0000269|PubMed:20308065, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:24882211, ECO:0000269|PubMed:26080397, ECO:0000269|PubMed:26246421, ECO:0000269|PubMed:30538141, ECO:0000269|PubMed:30770470, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:38534334, ECO:0000269|PubMed:39567688}.; FUNCTION: (Microbial infection) Deacetylates the SARS-CoV-2 N protein which promotes association of the viral N protein with human G3BP1, leading to disruption of cellular stress granule formation and facilitating viral replication. {ECO:0000269|PubMed:39135075}. |
| Q9UGL1 | KDM5B | S1328 | ochoa|psp | Lysine-specific demethylase 5B (EC 1.14.11.67) (Cancer/testis antigen 31) (CT31) (Histone demethylase JARID1B) (Jumonji/ARID domain-containing protein 1B) (PLU-1) (Retinoblastoma-binding protein 2 homolog 1) (RBP2-H1) ([histone H3]-trimethyl-L-lysine(4) demethylase 5B) | Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:24952722, PubMed:27214403, PubMed:28262558). Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5 (PubMed:24952722). In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity). {ECO:0000250|UniProtKB:Q80Y84, ECO:0000269|PubMed:12657635, ECO:0000269|PubMed:16645588, ECO:0000269|PubMed:17320161, ECO:0000269|PubMed:17363312, ECO:0000269|PubMed:24952722, ECO:0000269|PubMed:26645689, ECO:0000269|PubMed:26741168, ECO:0000269|PubMed:27214403, ECO:0000269|PubMed:28262558}. |
| Q9UHB9 | SRP68 | S241 | ochoa | Signal recognition particle subunit SRP68 (SRP68) (Signal recognition particle 68 kDa protein) | Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:34020957). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER (PubMed:34020957). The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER (PubMed:34020957). Binds the signal recognition particle RNA (7SL RNA), SRP72 binds to this complex subsequently (PubMed:16672232, PubMed:27899666). The SRP complex possibly participates in the elongation arrest function (By similarity). {ECO:0000250|UniProtKB:P38687, ECO:0000269|PubMed:16672232, ECO:0000269|PubMed:27899666, ECO:0000269|PubMed:34020957}. |
| Q9UHQ1 | NARF | S196 | ochoa | Nuclear prelamin A recognition factor (Iron-only hydrogenase-like protein 2) (IOP2) | None |
| Q9UIJ5 | ZDHHC2 | S248 | ochoa | Palmitoyltransferase ZDHHC2 (EC 2.3.1.225) (Acyltransferase ZDHHC2) (EC 2.3.1.-) (Reduced expression associated with metastasis protein) (Ream) (Reduced expression in cancer protein) (Rec) (Zinc finger DHHC domain-containing protein 2) (DHHC-2) (Zinc finger protein 372) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes (PubMed:18296695, PubMed:18508921, PubMed:19144824, PubMed:21343290, PubMed:22034844, PubMed:23793055). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). In the nervous system, plays a role in long term synaptic potentiation by palmitoylating AKAP5 through which it regulates protein trafficking from the dendritic recycling endosomes to the plasma membrane and controls both structural and functional plasticity at excitatory synapses (By similarity). In dendrites, mediates the palmitoylation of DLG4 when synaptic activity decreases and induces synaptic clustering of DLG4 and associated AMPA-type glutamate receptors (By similarity). Also mediates the de novo and turnover palmitoylation of RGS7BP, a shuttle for Gi/o-specific GTPase-activating proteins/GAPs, promoting its localization to the plasma membrane in response to the activation of G protein-coupled receptors. Through the localization of these GTPase-activating proteins/GAPs, it also probably plays a role in G protein-coupled receptors signaling in neurons (By similarity). Also probably plays a role in cell adhesion by palmitoylating CD9 and CD151 to regulate their expression and function (PubMed:18508921). Palmitoylates the endoplasmic reticulum protein CKAP4 and regulates its localization to the plasma membrane (PubMed:18296695, PubMed:19144824). Could also palmitoylate LCK and regulate its localization to the plasma membrane (PubMed:22034844). {ECO:0000250|UniProtKB:P59267, ECO:0000250|UniProtKB:Q9JKR5, ECO:0000269|PubMed:18296695, ECO:0000269|PubMed:18508921, ECO:0000269|PubMed:19144824, ECO:0000269|PubMed:21343290, ECO:0000269|PubMed:22034844, ECO:0000269|PubMed:23793055}.; FUNCTION: (Microbial infection) Promotes Chikungunya virus (CHIKV) replication by mediating viral nsp1 palmitoylation. {ECO:0000269|PubMed:30404808}. |
| Q9ULD2 | MTUS1 | S399 | ochoa | Microtubule-associated tumor suppressor 1 (AT2 receptor-binding protein) (Angiotensin-II type 2 receptor-interacting protein) (Mitochondrial tumor suppressor 1) | Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. {ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:19794912}. |
| Q9ULD6 | INTU | S674 | ochoa | Protein inturned (Inturned planar cell polarity effector homolog) (PDZ domain-containing protein 6) | Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling (By similarity). Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (PubMed:27158779). Required for recruitment of CPLANE2 to the mother centriole (By similarity). Binds phosphatidylinositol 3-phosphate with highest affinity, followed by phosphatidylinositol 4-phosphate and phosphatidylinositol 5-phosphate (By similarity). {ECO:0000250|UniProtKB:Q059U7, ECO:0000250|UniProtKB:Q2I0E5, ECO:0000305|PubMed:27158779}. |
| Q9ULH7 | MRTFB | S66 | ochoa | Myocardin-related transcription factor B (MRTF-B) (MKL/myocardin-like protein 2) (Megakaryoblastic leukemia 2) | Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation. {ECO:0000269|PubMed:14565952}. |
| Q9UPN3 | MACF1 | S1367 | ochoa | Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) | [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250|UniProtKB:Q9QXZ0, ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:27693509}. |
| Q9UPN3 | MACF1 | S6032 | ochoa | Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) | [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250|UniProtKB:Q9QXZ0, ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:27693509}. |
| Q9UPP1 | PHF8 | S175 | ochoa | Histone lysine demethylase PHF8 (EC 1.14.11.27) (EC 1.14.11.65) (PHD finger protein 8) ([histone H3]-dimethyl-L-lysine(36) demethylase PHF8) ([histone H3]-dimethyl-L-lysine(9) demethylase PHF8) | Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Required for brain development, probably by regulating expression of neuron-specific genes. Only has activity toward H4K20Me1 when nucleosome is used as a substrate and when not histone octamer is used as substrate. May also have weak activity toward dimethylated H3 'Lys-36' (H3K36Me2), however, the relevance of this result remains unsure in vivo. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: has weak activity toward H3K9Me2 in absence of H3K4me3, while it has high activity toward H3K9me2 when binding H3K4me3. Positively modulates transcription of histone demethylase KDM5C, acting synergistically with transcription factor ARX; synergy may be related to enrichment of histone H3K4me3 in regulatory elements. {ECO:0000269|PubMed:19843542, ECO:0000269|PubMed:20023638, ECO:0000269|PubMed:20101266, ECO:0000269|PubMed:20208542, ECO:0000269|PubMed:20346720, ECO:0000269|PubMed:20421419, ECO:0000269|PubMed:20531378, ECO:0000269|PubMed:20548336, ECO:0000269|PubMed:20622853, ECO:0000269|PubMed:20622854, ECO:0000269|PubMed:31691806}. |
| Q9UQ88 | CDK11A | S577 | ochoa | Cyclin-dependent kinase 11A (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 2) (Cell division protein kinase 11A) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L2) | Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression. {ECO:0000269|PubMed:12501247, ECO:0000269|PubMed:12624090}. |
| Q9Y2K5 | R3HDM2 | S853 | ochoa | R3H domain-containing protein 2 | None |
| Q9Y2U8 | LEMD3 | S881 | ochoa | Inner nuclear membrane protein Man1 (LEM domain-containing protein 3) | Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. {ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15647271}. |
| Q9Y3P9 | RABGAP1 | S134 | ochoa | Rab GTPase-activating protein 1 (GAP and centrosome-associated protein) (Rab6 GTPase-activating protein GAPCenA) | May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by centrosome. May participate in a RAB6A-mediated pathway involved in the metaphase-anaphase transition. {ECO:0000269|PubMed:10202141, ECO:0000269|PubMed:16395330}. |
| Q9Y5A9 | YTHDF2 | S196 | ochoa | YTH domain-containing family protein 2 (DF2) (CLL-associated antigen KW-14) (High-glucose-regulated protein 8) (Renal carcinoma antigen NY-REN-2) | Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates their stability (PubMed:24284625, PubMed:26046440, PubMed:26318451, PubMed:32492408). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing (PubMed:22575960, PubMed:24284625, PubMed:25412658, PubMed:25412661, PubMed:32492408). Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT and ribonuclease P/MRP complexes, depending on the context (PubMed:24284625, PubMed:26046440, PubMed:27558897, PubMed:30930054, PubMed:32492408). The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) share m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation (PubMed:28106072, PubMed:32492408). M6A-containing mRNAs containing a binding site for RIDA/HRSP12 (5'-GGUUC-3') are preferentially degraded by endoribonucleolytic cleavage: cooperative binding of RIDA/HRSP12 and YTHDF2 to transcripts leads to recruitment of the ribonuclease P/MRP complex (PubMed:30930054). Other m6A-containing mRNAs undergo deadenylation via direct interaction between YTHDF2 and CNOT1, leading to recruitment of the CCR4-NOT and subsequent deadenylation of m6A-containing mRNAs (PubMed:27558897). Required maternally to regulate oocyte maturation: probably acts by binding to m6A-containing mRNAs, thereby regulating maternal transcript dosage during oocyte maturation, which is essential for the competence of oocytes to sustain early zygotic development (By similarity). Also required during spermatogenesis: regulates spermagonial adhesion by promoting degradation of m6A-containing transcripts coding for matrix metallopeptidases (By similarity). Also involved in hematopoietic stem cells specification by binding to m6A-containing mRNAs, leading to promote their degradation (PubMed:30065315). Also acts as a regulator of neural development by promoting m6A-dependent degradation of neural development-related mRNA targets (By similarity). Inhibits neural specification of induced pluripotent stem cells by binding to methylated neural-specific mRNAs and promoting their degradation, thereby restraining neural differentiation (PubMed:32169943). Regulates circadian regulation of hepatic lipid metabolism: acts by promoting m6A-dependent degradation of PPARA transcripts (PubMed:30428350). Regulates the innate immune response to infection by inhibiting the type I interferon response: acts by binding to m6A-containing IFNB transcripts and promoting their degradation (PubMed:30559377). May also act as a promoter of cap-independent mRNA translation following heat shock stress: upon stress, relocalizes to the nucleus and specifically binds mRNAs with some m6A methylation mark at their 5'-UTR, protecting demethylation of mRNAs by FTO, thereby promoting cap-independent mRNA translation (PubMed:26458103). Regulates mitotic entry by promoting the phase-specific m6A-dependent degradation of WEE1 transcripts (PubMed:32267835). Promotes formation of phase-separated membraneless compartments, such as P-bodies or stress granules, by undergoing liquid-liquid phase separation upon binding to mRNAs containing multiple m6A-modified residues: polymethylated mRNAs act as a multivalent scaffold for the binding of YTHDF proteins, juxtaposing their disordered regions and thereby leading to phase separation (PubMed:31292544, PubMed:31388144, PubMed:31642031, PubMed:32451507). The resulting mRNA-YTHDF complexes then partition into different endogenous phase-separated membraneless compartments, such as P-bodies, stress granules or neuronal RNA granules (PubMed:31292544). May also recognize and bind RNAs modified by C5-methylcytosine (m5C) and act as a regulator of rRNA processing (PubMed:31815440). {ECO:0000250|UniProtKB:Q91YT7, ECO:0000269|PubMed:22575960, ECO:0000269|PubMed:24284625, ECO:0000269|PubMed:25412658, ECO:0000269|PubMed:25412661, ECO:0000269|PubMed:26046440, ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:26458103, ECO:0000269|PubMed:27558897, ECO:0000269|PubMed:28106072, ECO:0000269|PubMed:30065315, ECO:0000269|PubMed:30428350, ECO:0000269|PubMed:30559377, ECO:0000269|PubMed:30930054, ECO:0000269|PubMed:31292544, ECO:0000269|PubMed:31388144, ECO:0000269|PubMed:31642031, ECO:0000269|PubMed:31815440, ECO:0000269|PubMed:32169943, ECO:0000269|PubMed:32267835, ECO:0000269|PubMed:32451507, ECO:0000269|PubMed:32492408}.; FUNCTION: (Microbial infection) Promotes viral gene expression and replication of polyomavirus SV40: acts by binding to N6-methyladenosine (m6A)-containing viral RNAs (PubMed:29447282). {ECO:0000269|PubMed:29447282}.; FUNCTION: (Microbial infection) Promotes viral gene expression and virion production of kaposis sarcoma-associated herpesvirus (KSHV) at some stage of the KSHV life cycle (in iSLK.219 and iSLK.BAC16 cells) (PubMed:29659627). Acts by binding to N6-methyladenosine (m6A)-containing viral RNAs (PubMed:29659627). {ECO:0000269|PubMed:29659627}. |
| Q9Y5Y5 | PEX16 | S138 | ochoa | Peroxisomal membrane protein PEX16 (Peroxin-16) (Peroxisomal biogenesis factor 16) | Required for peroxisome membrane biogenesis. May play a role in early stages of peroxisome assembly. Can recruit other peroxisomal proteins, such as PEX3 and PMP34, to de novo peroxisomes derived from the endoplasmic reticulum (ER). May function as receptor for PEX3. {ECO:0000269|PubMed:10704444, ECO:0000269|PubMed:12223482, ECO:0000269|PubMed:16717127}. |
| Q9Y6D6 | ARFGEF1 | S234 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (ADP-ribosylation factor guanine nucleotide-exchange factor 1) (p200 ARF guanine nucleotide exchange factor) (p200 ARF-GEP1) | Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturation of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Inhibits GAP activity of MYO9B probably through competitive RhoA binding. The function in the nucleus remains to be determined. {ECO:0000269|PubMed:12571360, ECO:0000269|PubMed:15644318, ECO:0000269|PubMed:17227842, ECO:0000269|PubMed:20360857, ECO:0000269|PubMed:22084092}. |
| Q9Y6D9 | MAD1L1 | S417 | ochoa | Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient 1-like protein 1) (MAD1-like protein 1) (Mitotic checkpoint MAD1 protein homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181) | Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate (PubMed:10049595, PubMed:20133940, PubMed:29162720). Forms a heterotetrameric complex with the closed conformation form of MAD2L1 (C-MAD2) at unattached kinetochores during prometaphase, recruits an open conformation of MAD2L1 (O-MAD2) and promotes the conversion of O-MAD2 to C-MAD2, which ensures mitotic checkpoint signaling (PubMed:29162720). {ECO:0000269|PubMed:10049595, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:36322655}.; FUNCTION: [Isoform 3]: Sequesters MAD2L1 in the cytoplasm preventing its function as an activator of the mitotic spindle assembly checkpoint (SAC) resulting in SAC impairment and chromosomal instability in hepatocellular carcinomas. {ECO:0000269|PubMed:19010891}. |
| Q9HAW4 | CLSPN | S1129 | EPSD|PSP | Claspin (hClaspin) | Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation (PubMed:12766152, PubMed:15190204, PubMed:15707391, PubMed:16123041). Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins (PubMed:12766152, PubMed:15096610, PubMed:15707391, PubMed:16123041). Also required to maintain normal rates of replication fork progression during unperturbed DNA replication. Binds directly to DNA, with particular affinity for branched or forked molecules and interacts with multiple protein components of the replisome such as the MCM2-7 complex and TIMELESS (PubMed:15226314, PubMed:34694004, PubMed:35585232). Important for initiation of DNA replication, recruits kinase CDC7 to phosphorylate MCM2-7 components (PubMed:27401717). {ECO:0000269|PubMed:12766152, ECO:0000269|PubMed:15096610, ECO:0000269|PubMed:15190204, ECO:0000269|PubMed:15226314, ECO:0000269|PubMed:15707391, ECO:0000269|PubMed:16123041, ECO:0000269|PubMed:27401717, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:35585232}. |
| Q13085 | ACACA | S1766 | Sugiyama | Acetyl-CoA carboxylase 1 (ACC1) (EC 6.4.1.2) (Acetyl-Coenzyme A carboxylase alpha) (ACC-alpha) | Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis (PubMed:20457939, PubMed:20952656, PubMed:29899443). This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:20457939, PubMed:20952656, PubMed:29899443). {ECO:0000269|PubMed:20457939, ECO:0000269|PubMed:20952656, ECO:0000269|PubMed:29899443}. |
| Q8N130 | SLC34A3 | S348 | Sugiyama | Sodium-dependent phosphate transport protein 2C (Sodium-phosphate transport protein 2C) (Na(+)-dependent phosphate cotransporter 2C) (Sodium/inorganic phosphate cotransporter IIC) (Sodium/phosphate cotransporter 2C) (Na(+)/Pi cotransporter 2C) (NaPi-2c) (Solute carrier family 34 member 3) | Involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane (PubMed:11880379). The cotransport has a Na(+):Pi stoichiometry of 2:1 and is electroneutral (By similarity). {ECO:0000250|UniProtKB:Q80SU6, ECO:0000269|PubMed:11880379}. |
| O15230 | LAMA5 | S422 | Sugiyama | Laminin subunit alpha-5 (Laminin-10 subunit alpha) (Laminin-11 subunit alpha) (Laminin-15 subunit alpha) | Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Plays a role in the regulation of skeletogenesis, through a mechanism that involves integrin-mediated signaling and PTK2B/PYK2 (PubMed:33242826). {ECO:0000269|PubMed:33242826}. |
| P17813 | ENG | S521 | Sugiyama | Endoglin (CD antigen CD105) | Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis (PubMed:21737454, PubMed:23300529). Required for normal structure and integrity of adult vasculature (PubMed:7894484). Regulates the migration of vascular endothelial cells (PubMed:17540773). Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors (PubMed:1692830). Acts as a TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors (PubMed:21737454, PubMed:22347366, PubMed:23300529, PubMed:8370410). Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3 (PubMed:21737454, PubMed:22347366, PubMed:23300529). {ECO:0000250|UniProtKB:Q63961, ECO:0000269|PubMed:17540773, ECO:0000269|PubMed:21737454, ECO:0000269|PubMed:23300529, ECO:0000269|PubMed:7894484, ECO:0000269|PubMed:8370410, ECO:0000305|PubMed:1692830}. |
| Q04760 | GLO1 | S114 | Sugiyama | Lactoylglutathione lyase (EC 4.4.1.5) (Aldoketomutase) (Glyoxalase I) (Glx I) (Ketone-aldehyde mutase) (Methylglyoxalase) (S-D-lactoylglutathione methylglyoxal lyase) | Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione (PubMed:20454679, PubMed:23122816, PubMed:9705294). Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B (PubMed:19199007). Required for normal osteoclastogenesis (By similarity). {ECO:0000250|UniProtKB:Q9CPU0, ECO:0000269|PubMed:19199007, ECO:0000269|PubMed:20454679, ECO:0000269|PubMed:23122816, ECO:0000269|PubMed:9705294}. |
| Q96AC1 | FERMT2 | S255 | Sugiyama | Fermitin family homolog 2 (Kindlin-2) (Mitogen-inducible gene 2 protein) (MIG-2) (Pleckstrin homology domain-containing family C member 1) (PH domain-containing family C member 1) | Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling. {ECO:0000269|PubMed:12679033, ECO:0000269|PubMed:18458155, ECO:0000269|PubMed:21325030, ECO:0000269|PubMed:22030399, ECO:0000269|PubMed:22078565, ECO:0000269|PubMed:22699938}. |
| Q16762 | TST | S202 | Sugiyama | Thiosulfate sulfurtransferase (EC 2.8.1.1) (Rhodanese) | Formation of iron-sulfur complexes, cyanide detoxification or modification of sulfur-containing enzymes. Other thiol compounds, besides cyanide, can act as sulfur ion acceptors. Also has weak mercaptopyruvate sulfurtransferase (MST) activity (By similarity). Together with MRPL18, acts as a mitochondrial import factor for the cytosolic 5S rRNA. Only the nascent unfolded cytoplasmic form is able to bind to the 5S rRNA. {ECO:0000250, ECO:0000269|PubMed:20663881, ECO:0000269|PubMed:21685364}. |
| Q9BQL6 | FERMT1 | S253 | Sugiyama | Fermitin family homolog 1 (Kindlerin) (Kindlin syndrome protein) (Kindlin-1) (Unc-112-related protein 1) | Involved in cell adhesion. Contributes to integrin activation. When coexpressed with talin, potentiates activation of ITGA2B. Required for normal keratinocyte proliferation. Required for normal polarization of basal keratinocytes in skin, and for normal cell shape. Required for normal adhesion of keratinocytes to fibronectin and laminin, and for normal keratinocyte migration to wound sites. May mediate TGF-beta 1 signaling in tumor progression. {ECO:0000269|PubMed:14634021, ECO:0000269|PubMed:17012746, ECO:0000269|PubMed:19804783}. |
| Q08378 | GOLGA3 | S500 | Sugiyama | Golgin subfamily A member 3 (Golgi complex-associated protein of 170 kDa) (GCP170) (Golgin-160) | Golgi auto-antigen; probably involved in maintaining Golgi structure. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-163765 | ChREBP activates metabolic gene expression | 0.000002 | 5.701 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.000005 | 5.306 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.000035 | 4.454 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.000076 | 4.119 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.000351 | 3.454 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.000584 | 3.234 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.000584 | 3.234 |
| R-HSA-2025928 | Calcineurin activates NFAT | 0.000694 | 3.159 |
| R-HSA-2033514 | FGFR3 mutant receptor activation | 0.001874 | 2.727 |
| R-HSA-1839130 | Signaling by activated point mutants of FGFR3 | 0.001874 | 2.727 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 0.001874 | 2.727 |
| R-HSA-9843745 | Adipogenesis | 0.001243 | 2.906 |
| R-HSA-3214842 | HDMs demethylate histones | 0.001035 | 2.985 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.001757 | 2.755 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.001609 | 2.793 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.001609 | 2.793 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 0.002202 | 2.657 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.002377 | 2.624 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 0.002959 | 2.529 |
| R-HSA-9942503 | Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) | 0.002959 | 2.529 |
| R-HSA-9945266 | Differentiation of T cells | 0.002959 | 2.529 |
| R-HSA-1640170 | Cell Cycle | 0.003548 | 2.450 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.004948 | 2.306 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.008409 | 2.075 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.009486 | 2.023 |
| R-HSA-69275 | G2/M Transition | 0.008985 | 2.046 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.009298 | 2.032 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.010377 | 1.984 |
| R-HSA-446107 | Type I hemidesmosome assembly | 0.010720 | 1.970 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 0.011641 | 1.934 |
| R-HSA-68875 | Mitotic Prophase | 0.012244 | 1.912 |
| R-HSA-4839726 | Chromatin organization | 0.014573 | 1.836 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.019312 | 1.714 |
| R-HSA-9734091 | Drug-mediated inhibition of MET activation | 0.027681 | 1.558 |
| R-HSA-2033515 | t(4;14) translocations of FGFR3 | 0.041234 | 1.385 |
| R-HSA-8853334 | Signaling by FGFR3 fusions in cancer | 0.041234 | 1.385 |
| R-HSA-5619097 | Defective SLC34A3 causes Hereditary hypophosphatemic rickets with hypercalciuria... | 0.041234 | 1.385 |
| R-HSA-4549380 | Defective ALG1 causes CDG-1k | 0.041234 | 1.385 |
| R-HSA-9674519 | Defective F8 sulfation at Y1699 | 0.054599 | 1.263 |
| R-HSA-8875513 | MET interacts with TNS proteins | 0.067778 | 1.169 |
| R-HSA-8865999 | MET activates PTPN11 | 0.067778 | 1.169 |
| R-HSA-5603037 | IRAK4 deficiency (TLR5) | 0.067778 | 1.169 |
| R-HSA-3656532 | TGFBR1 KD Mutants in Cancer | 0.080774 | 1.093 |
| R-HSA-68911 | G2 Phase | 0.093590 | 1.029 |
| R-HSA-3304356 | SMAD2/3 Phosphorylation Motif Mutants in Cancer | 0.093590 | 1.029 |
| R-HSA-5654227 | Phospholipase C-mediated cascade; FGFR3 | 0.026930 | 1.570 |
| R-HSA-8851907 | MET activates PI3K/AKT signaling | 0.130981 | 0.883 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.130981 | 0.883 |
| R-HSA-190371 | FGFR3b ligand binding and activation | 0.130981 | 0.883 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 0.130981 | 0.883 |
| R-HSA-9632974 | NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis | 0.130981 | 0.883 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 0.143100 | 0.844 |
| R-HSA-8875656 | MET receptor recycling | 0.143100 | 0.844 |
| R-HSA-9700645 | ALK mutants bind TKIs | 0.155051 | 0.810 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 0.048760 | 1.312 |
| R-HSA-5654704 | SHC-mediated cascade:FGFR3 | 0.052266 | 1.282 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 0.166835 | 0.778 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 0.166835 | 0.778 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 0.166835 | 0.778 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 0.166835 | 0.778 |
| R-HSA-5654706 | FRS-mediated FGFR3 signaling | 0.055860 | 1.253 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 0.055860 | 1.253 |
| R-HSA-416550 | Sema4D mediated inhibition of cell attachment and migration | 0.189916 | 0.721 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 0.189916 | 0.721 |
| R-HSA-8874081 | MET activates PTK2 signaling | 0.075026 | 1.125 |
| R-HSA-8851805 | MET activates RAS signaling | 0.201217 | 0.696 |
| R-HSA-3656253 | Defective EXT1 causes exostoses 1, TRPS2 and CHDS | 0.201217 | 0.696 |
| R-HSA-3656237 | Defective EXT2 causes exostoses 2 | 0.201217 | 0.696 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.087384 | 1.059 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.091630 | 1.038 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.095936 | 1.018 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.095936 | 1.018 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 0.234186 | 0.630 |
| R-HSA-8964315 | G beta:gamma signalling through BTK | 0.234186 | 0.630 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.104714 | 0.980 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.104714 | 0.980 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.109182 | 0.962 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.109182 | 0.962 |
| R-HSA-5083636 | Defective GALNT12 causes CRCS1 | 0.244872 | 0.611 |
| R-HSA-5083625 | Defective GALNT3 causes HFTC | 0.244872 | 0.611 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.028178 | 1.550 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 0.113700 | 0.944 |
| R-HSA-380287 | Centrosome maturation | 0.030413 | 1.517 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.118266 | 0.927 |
| R-HSA-3560783 | Defective B4GALT7 causes EDS, progeroid type | 0.255409 | 0.593 |
| R-HSA-4420332 | Defective B3GALT6 causes EDSP2 and SEMDJL1 | 0.255409 | 0.593 |
| R-HSA-5083632 | Defective C1GALT1C1 causes TNPS | 0.265800 | 0.575 |
| R-HSA-3560801 | Defective B3GAT3 causes JDSSDHD | 0.265800 | 0.575 |
| R-HSA-8875878 | MET promotes cell motility | 0.132225 | 0.879 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.136959 | 0.863 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.141730 | 0.849 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.296114 | 0.529 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.095284 | 1.021 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.305939 | 0.514 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 0.305939 | 0.514 |
| R-HSA-1989781 | PPARA activates gene expression | 0.036524 | 1.437 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 0.334603 | 0.475 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 0.334603 | 0.475 |
| R-HSA-977068 | Termination of O-glycan biosynthesis | 0.334603 | 0.475 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 0.343894 | 0.464 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.211405 | 0.675 |
| R-HSA-72649 | Translation initiation complex formation | 0.216523 | 0.664 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.226791 | 0.644 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.262935 | 0.580 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.262935 | 0.580 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.278457 | 0.555 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.038264 | 1.417 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 0.087384 | 1.059 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.360319 | 0.443 |
| R-HSA-6806834 | Signaling by MET | 0.350233 | 0.456 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.042022 | 1.377 |
| R-HSA-9646399 | Aggrephagy | 0.141730 | 0.849 |
| R-HSA-5654710 | PI-3K cascade:FGFR3 | 0.045344 | 1.343 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.020588 | 1.686 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.299114 | 0.524 |
| R-HSA-9603798 | Class I peroxisomal membrane protein import | 0.244872 | 0.611 |
| R-HSA-72086 | mRNA Capping | 0.388443 | 0.411 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.385272 | 0.414 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 0.024240 | 1.615 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.313767 | 0.503 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.313767 | 0.503 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.313767 | 0.503 |
| R-HSA-8866911 | TFAP2 (AP-2) family regulates transcription of cell cycle factors | 0.080774 | 1.093 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.030787 | 1.512 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.370997 | 0.431 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.314548 | 0.502 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 0.189916 | 0.721 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.255409 | 0.593 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 0.296114 | 0.529 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.171027 | 0.767 |
| R-HSA-190239 | FGFR3 ligand binding and activation | 0.029734 | 1.527 |
| R-HSA-444473 | Formyl peptide receptors bind formyl peptides and many other ligands | 0.143100 | 0.844 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.156246 | 0.806 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.036524 | 1.437 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.309411 | 0.509 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.315628 | 0.501 |
| R-HSA-9636249 | Inhibition of nitric oxide production | 0.067778 | 1.169 |
| R-HSA-6806942 | MET Receptor Activation | 0.118691 | 0.926 |
| R-HSA-450341 | Activation of the AP-1 family of transcription factors | 0.155051 | 0.810 |
| R-HSA-3000157 | Laminin interactions | 0.071043 | 1.148 |
| R-HSA-8949664 | Processing of SMDT1 | 0.212361 | 0.673 |
| R-HSA-975110 | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | 0.255409 | 0.593 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.255409 | 0.593 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.065228 | 1.186 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.304266 | 0.517 |
| R-HSA-8875791 | MET activates STAT3 | 0.067778 | 1.169 |
| R-HSA-427589 | Type II Na+/Pi cotransporters | 0.067778 | 1.169 |
| R-HSA-165181 | Inhibition of TSC complex formation by PKB | 0.080774 | 1.093 |
| R-HSA-3656534 | Loss of Function of TGFBR1 in Cancer | 0.093590 | 1.029 |
| R-HSA-3304349 | Loss of Function of SMAD2/3 in Cancer | 0.106228 | 0.974 |
| R-HSA-69478 | G2/M DNA replication checkpoint | 0.118691 | 0.926 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 0.155051 | 0.810 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.189916 | 0.721 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.029194 | 1.535 |
| R-HSA-190372 | FGFR3c ligand binding and activation | 0.223350 | 0.651 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.127530 | 0.894 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.136959 | 0.863 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.171027 | 0.767 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.325182 | 0.488 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 0.334603 | 0.475 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 0.370997 | 0.431 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.180648 | 0.743 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.309411 | 0.509 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.223536 | 0.651 |
| R-HSA-68877 | Mitotic Prometaphase | 0.347205 | 0.459 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.042022 | 1.377 |
| R-HSA-2424491 | DAP12 signaling | 0.091630 | 1.038 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.353055 | 0.452 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.221652 | 0.654 |
| R-HSA-9694614 | Attachment and Entry | 0.315628 | 0.501 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.112392 | 0.949 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.091630 | 1.038 |
| R-HSA-5694530 | Cargo concentration in the ER | 0.095936 | 1.018 |
| R-HSA-165159 | MTOR signalling | 0.156246 | 0.806 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.109182 | 0.962 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.226791 | 0.644 |
| R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 0.234186 | 0.630 |
| R-HSA-9729555 | Sensory perception of sour taste | 0.080774 | 1.093 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.027647 | 1.558 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.091630 | 1.038 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.104714 | 0.980 |
| R-HSA-429958 | mRNA decay by 3' to 5' exoribonuclease | 0.286150 | 0.543 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.176006 | 0.754 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 0.334603 | 0.475 |
| R-HSA-5621480 | Dectin-2 family | 0.231938 | 0.635 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.237093 | 0.625 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.242254 | 0.616 |
| R-HSA-191859 | snRNP Assembly | 0.242254 | 0.616 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.379781 | 0.420 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.252589 | 0.598 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.319677 | 0.495 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.350233 | 0.456 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.370347 | 0.431 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.064521 | 1.190 |
| R-HSA-68886 | M Phase | 0.028234 | 1.549 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.075026 | 1.125 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.041277 | 1.384 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 0.315628 | 0.501 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.343894 | 0.464 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.340094 | 0.468 |
| R-HSA-69481 | G2/M Checkpoints | 0.321397 | 0.493 |
| R-HSA-3304351 | Signaling by TGF-beta Receptor Complex in Cancer | 0.118691 | 0.926 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.055860 | 1.253 |
| R-HSA-5260271 | Diseases of Immune System | 0.141730 | 0.849 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.141730 | 0.849 |
| R-HSA-5334118 | DNA methylation | 0.388443 | 0.411 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.174811 | 0.757 |
| R-HSA-5617833 | Cilium Assembly | 0.172497 | 0.763 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.095936 | 1.018 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 0.104714 | 0.980 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.360319 | 0.443 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.365601 | 0.437 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.045125 | 1.346 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.247420 | 0.607 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.086231 | 1.064 |
| R-HSA-427652 | Sodium-coupled phosphate cotransporters | 0.106228 | 0.974 |
| R-HSA-389542 | NADPH regeneration | 0.118691 | 0.926 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 0.032649 | 1.486 |
| R-HSA-3371599 | Defective HLCS causes multiple carboxylase deficiency | 0.130981 | 0.883 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 0.166835 | 0.778 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.141730 | 0.849 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.325182 | 0.488 |
| R-HSA-429947 | Deadenylation of mRNA | 0.343894 | 0.464 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 0.353055 | 0.452 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.299114 | 0.524 |
| R-HSA-68882 | Mitotic Anaphase | 0.238697 | 0.622 |
| R-HSA-9612973 | Autophagy | 0.229463 | 0.639 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.094606 | 1.024 |
| R-HSA-2172127 | DAP12 interactions | 0.166074 | 0.780 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.241277 | 0.617 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.287123 | 0.542 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.355283 | 0.449 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.203431 | 0.692 |
| R-HSA-196780 | Biotin transport and metabolism | 0.029734 | 1.527 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.287123 | 0.542 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.298526 | 0.525 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.030787 | 1.512 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.298526 | 0.525 |
| R-HSA-1538133 | G0 and Early G1 | 0.100298 | 0.999 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.351780 | 0.454 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.083200 | 1.080 |
| R-HSA-6807070 | PTEN Regulation | 0.374690 | 0.426 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.109576 | 0.960 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.324797 | 0.488 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.103763 | 0.984 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.127735 | 0.894 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.100904 | 0.996 |
| R-HSA-200425 | Carnitine shuttle | 0.063295 | 1.199 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.132225 | 0.879 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 0.098078 | 1.008 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.176006 | 0.754 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.242254 | 0.616 |
| R-HSA-171319 | Telomere Extension By Telomerase | 0.379781 | 0.420 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.379781 | 0.420 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.103757 | 0.984 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.304266 | 0.517 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.304266 | 0.517 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.309411 | 0.509 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.388443 | 0.411 |
| R-HSA-1632852 | Macroautophagy | 0.183328 | 0.737 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.355283 | 0.449 |
| R-HSA-8957322 | Metabolism of steroids | 0.055437 | 1.256 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 0.035671 | 1.448 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 0.234186 | 0.630 |
| R-HSA-9637687 | Suppression of phagosomal maturation | 0.362088 | 0.441 |
| R-HSA-70171 | Glycolysis | 0.072449 | 1.140 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.156997 | 0.804 |
| R-HSA-168255 | Influenza Infection | 0.303055 | 0.518 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.098557 | 1.006 |
| R-HSA-3323169 | Defects in biotin (Btn) metabolism | 0.155051 | 0.810 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 0.155051 | 0.810 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.223350 | 0.651 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.118266 | 0.927 |
| R-HSA-1614517 | Sulfide oxidation to sulfate | 0.265800 | 0.575 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.276046 | 0.559 |
| R-HSA-9755088 | Ribavirin ADME | 0.315628 | 0.501 |
| R-HSA-109704 | PI3K Cascade | 0.196131 | 0.707 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.306143 | 0.514 |
| R-HSA-373753 | Nephrin family interactions | 0.048760 | 1.312 |
| R-HSA-9659379 | Sensory processing of sound | 0.345170 | 0.462 |
| R-HSA-8877330 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | 0.212361 | 0.673 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.268372 | 0.571 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.220588 | 0.656 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.059537 | 1.225 |
| R-HSA-8854214 | TBC/RABGAPs | 0.161146 | 0.793 |
| R-HSA-2161541 | Abacavir metabolism | 0.305939 | 0.514 |
| R-HSA-1855183 | Synthesis of IP2, IP, and Ins in the cytosol | 0.362088 | 0.441 |
| R-HSA-9638630 | Attachment of bacteria to epithelial cells | 0.362088 | 0.441 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.128413 | 0.891 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.257762 | 0.589 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.288794 | 0.539 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.067131 | 1.173 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.067131 | 1.173 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.285039 | 0.545 |
| R-HSA-8983711 | OAS antiviral response | 0.201217 | 0.696 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.098078 | 1.008 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.118524 | 0.926 |
| R-HSA-9955298 | SLC-mediated transport of organic anions | 0.340094 | 0.468 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.130997 | 0.883 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.248119 | 0.605 |
| R-HSA-1266738 | Developmental Biology | 0.084336 | 1.074 |
| R-HSA-9909396 | Circadian clock | 0.344284 | 0.463 |
| R-HSA-9662001 | Defective factor VIII causes hemophilia A | 0.118691 | 0.926 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.079080 | 1.102 |
| R-HSA-428643 | Organic anion transport by SLC5/17/25 transporters | 0.276046 | 0.559 |
| R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 0.353055 | 0.452 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.226791 | 0.644 |
| R-HSA-74160 | Gene expression (Transcription) | 0.066662 | 1.176 |
| R-HSA-9707616 | Heme signaling | 0.257762 | 0.589 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.388443 | 0.411 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 0.244872 | 0.611 |
| R-HSA-9664420 | Killing mechanisms | 0.244872 | 0.611 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.113700 | 0.944 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.065228 | 1.186 |
| R-HSA-879518 | Organic anion transport by SLCO transporters | 0.334603 | 0.475 |
| R-HSA-112399 | IRS-mediated signalling | 0.231938 | 0.635 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.370997 | 0.431 |
| R-HSA-9833110 | RSV-host interactions | 0.223555 | 0.651 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.045214 | 1.345 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.156784 | 0.805 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.258683 | 0.587 |
| R-HSA-3371556 | Cellular response to heat stress | 0.123594 | 0.908 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.155051 | 0.810 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.055860 | 1.253 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.212361 | 0.673 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.234186 | 0.630 |
| R-HSA-2161522 | Abacavir ADME | 0.362088 | 0.441 |
| R-HSA-70326 | Glucose metabolism | 0.114196 | 0.942 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.148447 | 0.828 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.325213 | 0.488 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.116515 | 0.934 |
| R-HSA-162582 | Signal Transduction | 0.210168 | 0.677 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 0.286150 | 0.543 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.262935 | 0.580 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.169599 | 0.771 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.083102 | 1.080 |
| R-HSA-75153 | Apoptotic execution phase | 0.041277 | 1.384 |
| R-HSA-3000178 | ECM proteoglycans | 0.304266 | 0.517 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.122461 | 0.912 |
| R-HSA-9706369 | Negative regulation of FLT3 | 0.244872 | 0.611 |
| R-HSA-9754706 | Atorvastatin ADME | 0.244872 | 0.611 |
| R-HSA-163685 | Integration of energy metabolism | 0.021883 | 1.660 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.252589 | 0.598 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.075026 | 1.125 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 0.353055 | 0.452 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.325182 | 0.488 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.096547 | 1.015 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.122877 | 0.911 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.112529 | 0.949 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.257762 | 0.589 |
| R-HSA-264876 | Insulin processing | 0.370997 | 0.431 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.268110 | 0.572 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.136959 | 0.863 |
| R-HSA-9651496 | Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) | 0.255409 | 0.593 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.334603 | 0.475 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.100298 | 0.999 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.273284 | 0.563 |
| R-HSA-212436 | Generic Transcription Pathway | 0.078935 | 1.103 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.353055 | 0.452 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.353055 | 0.452 |
| R-HSA-9671793 | Diseases of hemostasis | 0.286150 | 0.543 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.171027 | 0.767 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.379781 | 0.420 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.268110 | 0.572 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.172315 | 0.764 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.242254 | 0.616 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.273284 | 0.563 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.211809 | 0.674 |
| R-HSA-9828806 | Maturation of hRSV A proteins | 0.370997 | 0.431 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.344040 | 0.463 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.329907 | 0.482 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.389798 | 0.409 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.389798 | 0.409 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.390213 | 0.409 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.390213 | 0.409 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.395136 | 0.403 |
| R-HSA-9663891 | Selective autophagy | 0.395136 | 0.403 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.404816 | 0.393 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.404928 | 0.393 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 0.405408 | 0.392 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 0.405408 | 0.392 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.408554 | 0.389 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.409796 | 0.387 |
| R-HSA-69242 | S Phase | 0.412286 | 0.385 |
| R-HSA-166520 | Signaling by NTRKs | 0.412286 | 0.385 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.413476 | 0.384 |
| R-HSA-2024096 | HS-GAG degradation | 0.413714 | 0.383 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.415735 | 0.381 |
| R-HSA-9679506 | SARS-CoV Infections | 0.419371 | 0.377 |
| R-HSA-391251 | Protein folding | 0.419473 | 0.377 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.419473 | 0.377 |
| R-HSA-397795 | G-protein beta:gamma signalling | 0.421904 | 0.375 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.421904 | 0.375 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.421904 | 0.375 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.424281 | 0.372 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.424281 | 0.372 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.427136 | 0.369 |
| R-HSA-1474290 | Collagen formation | 0.429069 | 0.367 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 0.429980 | 0.367 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 0.429980 | 0.367 |
| R-HSA-189483 | Heme degradation | 0.429980 | 0.367 |
| R-HSA-69306 | DNA Replication | 0.430829 | 0.366 |
| R-HSA-1971475 | Glycosaminoglycan-protein linkage region biosynthesis | 0.437944 | 0.359 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 0.437944 | 0.359 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.437944 | 0.359 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 0.437944 | 0.359 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 0.437944 | 0.359 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.437944 | 0.359 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.438188 | 0.358 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.438581 | 0.358 |
| R-HSA-73894 | DNA Repair | 0.442978 | 0.354 |
| R-HSA-162587 | HIV Life Cycle | 0.445512 | 0.351 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 0.445798 | 0.351 |
| R-HSA-3296482 | Defects in vitamin and cofactor metabolism | 0.445798 | 0.351 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.450369 | 0.346 |
| R-HSA-190236 | Signaling by FGFR | 0.452687 | 0.344 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.452687 | 0.344 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.452687 | 0.344 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.452687 | 0.344 |
| R-HSA-2022928 | HS-GAG biosynthesis | 0.453542 | 0.343 |
| R-HSA-8853659 | RET signaling | 0.453542 | 0.343 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 0.453542 | 0.343 |
| R-HSA-9845576 | Glycosphingolipid transport | 0.453542 | 0.343 |
| R-HSA-3371511 | HSF1 activation | 0.453542 | 0.343 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.453542 | 0.343 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.453542 | 0.343 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.456427 | 0.341 |
| R-HSA-162906 | HIV Infection | 0.456915 | 0.340 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.459980 | 0.337 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.461178 | 0.336 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.461178 | 0.336 |
| R-HSA-109581 | Apoptosis | 0.463654 | 0.334 |
| R-HSA-9931953 | Biofilm formation | 0.468708 | 0.329 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.468708 | 0.329 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.471177 | 0.327 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.471177 | 0.327 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.471177 | 0.327 |
| R-HSA-1483255 | PI Metabolism | 0.471177 | 0.327 |
| R-HSA-9675108 | Nervous system development | 0.473000 | 0.325 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.476133 | 0.322 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.476133 | 0.322 |
| R-HSA-201556 | Signaling by ALK | 0.476133 | 0.322 |
| R-HSA-3781860 | Diseases associated with N-glycosylation of proteins | 0.476133 | 0.322 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 0.476133 | 0.322 |
| R-HSA-5619102 | SLC transporter disorders | 0.481535 | 0.317 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.483455 | 0.316 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.483455 | 0.316 |
| R-HSA-167169 | HIV Transcription Elongation | 0.483455 | 0.316 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.483455 | 0.316 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.483455 | 0.316 |
| R-HSA-202433 | Generation of second messenger molecules | 0.483455 | 0.316 |
| R-HSA-8982491 | Glycogen metabolism | 0.483455 | 0.316 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.484798 | 0.314 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.484798 | 0.314 |
| R-HSA-8939211 | ESR-mediated signaling | 0.487286 | 0.312 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.489290 | 0.310 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 0.490675 | 0.309 |
| R-HSA-9694548 | Maturation of spike protein | 0.490675 | 0.309 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 0.490675 | 0.309 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.490675 | 0.309 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 0.490675 | 0.309 |
| R-HSA-9607240 | FLT3 Signaling | 0.490675 | 0.309 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.493758 | 0.306 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.497795 | 0.303 |
| R-HSA-167161 | HIV Transcription Initiation | 0.497795 | 0.303 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.497795 | 0.303 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.497795 | 0.303 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.497795 | 0.303 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.498200 | 0.303 |
| R-HSA-211000 | Gene Silencing by RNA | 0.498200 | 0.303 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.501406 | 0.300 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.502618 | 0.299 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.502618 | 0.299 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.502618 | 0.299 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.502618 | 0.299 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.504815 | 0.297 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 0.504815 | 0.297 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.507011 | 0.295 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.507011 | 0.295 |
| R-HSA-1500931 | Cell-Cell communication | 0.509673 | 0.293 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.511379 | 0.291 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.511379 | 0.291 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.511738 | 0.291 |
| R-HSA-9710421 | Defective pyroptosis | 0.511738 | 0.291 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.511738 | 0.291 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 0.511738 | 0.291 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.518564 | 0.285 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.518564 | 0.285 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.518564 | 0.285 |
| R-HSA-69236 | G1 Phase | 0.518564 | 0.285 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.518564 | 0.285 |
| R-HSA-5683826 | Surfactant metabolism | 0.518564 | 0.285 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.520039 | 0.284 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.524330 | 0.280 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.525296 | 0.280 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.525296 | 0.280 |
| R-HSA-3560782 | Diseases associated with glycosaminoglycan metabolism | 0.525296 | 0.280 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.525296 | 0.280 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.525296 | 0.280 |
| R-HSA-1614558 | Degradation of cysteine and homocysteine | 0.525296 | 0.280 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.528595 | 0.277 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.528595 | 0.277 |
| R-HSA-2559583 | Cellular Senescence | 0.530029 | 0.276 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.531933 | 0.274 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.531933 | 0.274 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.531933 | 0.274 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.531933 | 0.274 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.531933 | 0.274 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.533237 | 0.273 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.537049 | 0.270 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.537049 | 0.270 |
| R-HSA-437239 | Recycling pathway of L1 | 0.538479 | 0.269 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.538479 | 0.269 |
| R-HSA-3781865 | Diseases of glycosylation | 0.543418 | 0.265 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.544933 | 0.264 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.544933 | 0.264 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.545398 | 0.263 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.545398 | 0.263 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.549533 | 0.260 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.549533 | 0.260 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.551297 | 0.259 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.551297 | 0.259 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.551297 | 0.259 |
| R-HSA-5693538 | Homology Directed Repair | 0.553642 | 0.257 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.557573 | 0.254 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.557724 | 0.254 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.563761 | 0.249 |
| R-HSA-156584 | Cytosolic sulfonation of small molecules | 0.563761 | 0.249 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.565810 | 0.247 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.569863 | 0.244 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.569863 | 0.244 |
| R-HSA-72187 | mRNA 3'-end processing | 0.569863 | 0.244 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.569863 | 0.244 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.569863 | 0.244 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.569863 | 0.244 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.569863 | 0.244 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.575880 | 0.240 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 0.575880 | 0.240 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.575880 | 0.240 |
| R-HSA-8956320 | Nucleotide biosynthesis | 0.575880 | 0.240 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.576357 | 0.239 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.577738 | 0.238 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.581814 | 0.235 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.581814 | 0.235 |
| R-HSA-9609690 | HCMV Early Events | 0.582232 | 0.235 |
| R-HSA-69206 | G1/S Transition | 0.585557 | 0.232 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.593433 | 0.227 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.600843 | 0.221 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.603892 | 0.219 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.604732 | 0.218 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.604732 | 0.218 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.606002 | 0.218 |
| R-HSA-1638091 | Heparan sulfate/heparin (HS-GAG) metabolism | 0.610263 | 0.214 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.610263 | 0.214 |
| R-HSA-180786 | Extension of Telomeres | 0.610263 | 0.214 |
| R-HSA-5357801 | Programmed Cell Death | 0.612946 | 0.213 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.613828 | 0.212 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.615717 | 0.211 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.615717 | 0.211 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.615717 | 0.211 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.615717 | 0.211 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.615717 | 0.211 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.615717 | 0.211 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.615762 | 0.211 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.621096 | 0.207 |
| R-HSA-450294 | MAP kinase activation | 0.621096 | 0.207 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.621096 | 0.207 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.626399 | 0.203 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.626399 | 0.203 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.627669 | 0.202 |
| R-HSA-6799198 | Complex I biogenesis | 0.631629 | 0.200 |
| R-HSA-373755 | Semaphorin interactions | 0.631629 | 0.200 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.631629 | 0.200 |
| R-HSA-1280218 | Adaptive Immune System | 0.640925 | 0.193 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.641870 | 0.193 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.646884 | 0.189 |
| R-HSA-9748784 | Drug ADME | 0.650565 | 0.187 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.651828 | 0.186 |
| R-HSA-913709 | O-linked glycosylation of mucins | 0.656703 | 0.183 |
| R-HSA-167172 | Transcription of the HIV genome | 0.656703 | 0.183 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.660157 | 0.180 |
| R-HSA-6798695 | Neutrophil degranulation | 0.664098 | 0.178 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.666250 | 0.176 |
| R-HSA-448424 | Interleukin-17 signaling | 0.666250 | 0.176 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 0.670924 | 0.173 |
| R-HSA-975634 | Retinoid metabolism and transport | 0.670924 | 0.173 |
| R-HSA-8978934 | Metabolism of cofactors | 0.670924 | 0.173 |
| R-HSA-189445 | Metabolism of porphyrins | 0.670924 | 0.173 |
| R-HSA-913531 | Interferon Signaling | 0.671503 | 0.173 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.672392 | 0.172 |
| R-HSA-74259 | Purine catabolism | 0.675533 | 0.170 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.680077 | 0.167 |
| R-HSA-4086398 | Ca2+ pathway | 0.680077 | 0.167 |
| R-HSA-9749641 | Aspirin ADME | 0.680077 | 0.167 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.682927 | 0.166 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.683850 | 0.165 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.684558 | 0.165 |
| R-HSA-449147 | Signaling by Interleukins | 0.688711 | 0.162 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.688977 | 0.162 |
| R-HSA-8852135 | Protein ubiquitination | 0.688977 | 0.162 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 0.688977 | 0.162 |
| R-HSA-9609507 | Protein localization | 0.693169 | 0.159 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.693334 | 0.159 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.693334 | 0.159 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.697630 | 0.156 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.701867 | 0.154 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.701867 | 0.154 |
| R-HSA-216083 | Integrin cell surface interactions | 0.701867 | 0.154 |
| R-HSA-191273 | Cholesterol biosynthesis | 0.701867 | 0.154 |
| R-HSA-9610379 | HCMV Late Events | 0.705242 | 0.152 |
| R-HSA-9711097 | Cellular response to starvation | 0.708198 | 0.150 |
| R-HSA-9833482 | PKR-mediated signaling | 0.710163 | 0.149 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.710163 | 0.149 |
| R-HSA-6806667 | Metabolism of fat-soluble vitamins | 0.714224 | 0.146 |
| R-HSA-977225 | Amyloid fiber formation | 0.714224 | 0.146 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.722178 | 0.141 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.724894 | 0.140 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.725419 | 0.139 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.726072 | 0.139 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.726072 | 0.139 |
| R-HSA-1474244 | Extracellular matrix organization | 0.727522 | 0.138 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.729912 | 0.137 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.729912 | 0.137 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.729912 | 0.137 |
| R-HSA-9609646 | HCMV Infection | 0.731834 | 0.136 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.733698 | 0.134 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.733698 | 0.134 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.733698 | 0.134 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 0.737431 | 0.132 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.737431 | 0.132 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 0.737431 | 0.132 |
| R-HSA-70268 | Pyruvate metabolism | 0.741112 | 0.130 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.744421 | 0.128 |
| R-HSA-72306 | tRNA processing | 0.744421 | 0.128 |
| R-HSA-156902 | Peptide chain elongation | 0.744741 | 0.128 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.745302 | 0.128 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.747385 | 0.126 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.748320 | 0.126 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.749641 | 0.125 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.752216 | 0.124 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.754768 | 0.122 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.755329 | 0.122 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.755329 | 0.122 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.757298 | 0.121 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.758760 | 0.120 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.762143 | 0.118 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.762143 | 0.118 |
| R-HSA-416476 | G alpha (q) signalling events | 0.762418 | 0.118 |
| R-HSA-611105 | Respiratory electron transport | 0.764754 | 0.116 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.772012 | 0.112 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.772012 | 0.112 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.775211 | 0.111 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.778364 | 0.109 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.778364 | 0.109 |
| R-HSA-157579 | Telomere Maintenance | 0.781474 | 0.107 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.781474 | 0.107 |
| R-HSA-1643685 | Disease | 0.784208 | 0.106 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.784540 | 0.105 |
| R-HSA-422356 | Regulation of insulin secretion | 0.784540 | 0.105 |
| R-HSA-3214847 | HATs acetylate histones | 0.787563 | 0.104 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.788190 | 0.103 |
| R-HSA-446728 | Cell junction organization | 0.790129 | 0.102 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.790544 | 0.102 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.790544 | 0.102 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.793483 | 0.100 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.793483 | 0.100 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.795706 | 0.099 |
| R-HSA-9658195 | Leishmania infection | 0.795706 | 0.099 |
| R-HSA-556833 | Metabolism of lipids | 0.796967 | 0.099 |
| R-HSA-192823 | Viral mRNA Translation | 0.799239 | 0.097 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.802057 | 0.096 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.802057 | 0.096 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.807575 | 0.093 |
| R-HSA-422475 | Axon guidance | 0.808454 | 0.092 |
| R-HSA-69239 | Synthesis of DNA | 0.812940 | 0.090 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.813590 | 0.090 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.813590 | 0.090 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.815566 | 0.089 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.818156 | 0.087 |
| R-HSA-1483257 | Phospholipid metabolism | 0.820130 | 0.086 |
| R-HSA-202403 | TCR signaling | 0.820709 | 0.086 |
| R-HSA-9824446 | Viral Infection Pathways | 0.823893 | 0.084 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.825710 | 0.083 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.825710 | 0.083 |
| R-HSA-6805567 | Keratinization | 0.827124 | 0.082 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.828157 | 0.082 |
| R-HSA-199991 | Membrane Trafficking | 0.832101 | 0.080 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.832951 | 0.079 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 0.837611 | 0.077 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.837611 | 0.077 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.837611 | 0.077 |
| R-HSA-373760 | L1CAM interactions | 0.839892 | 0.076 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.842142 | 0.075 |
| R-HSA-73886 | Chromosome Maintenance | 0.850829 | 0.070 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 0.850829 | 0.070 |
| R-HSA-8953854 | Metabolism of RNA | 0.852959 | 0.069 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.854993 | 0.068 |
| R-HSA-168249 | Innate Immune System | 0.858651 | 0.066 |
| R-HSA-194138 | Signaling by VEGF | 0.861022 | 0.065 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.862976 | 0.064 |
| R-HSA-2262752 | Cellular responses to stress | 0.868173 | 0.061 |
| R-HSA-8956319 | Nucleotide catabolism | 0.868675 | 0.061 |
| R-HSA-72312 | rRNA processing | 0.869994 | 0.060 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.870725 | 0.060 |
| R-HSA-9717189 | Sensory perception of taste | 0.874138 | 0.058 |
| R-HSA-15869 | Metabolism of nucleotides | 0.875652 | 0.058 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.875908 | 0.058 |
| R-HSA-5668914 | Diseases of metabolism | 0.876216 | 0.057 |
| R-HSA-157118 | Signaling by NOTCH | 0.881084 | 0.055 |
| R-HSA-168256 | Immune System | 0.882093 | 0.054 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.884394 | 0.053 |
| R-HSA-5173105 | O-linked glycosylation | 0.886021 | 0.053 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.887624 | 0.052 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.887624 | 0.052 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.890765 | 0.050 |
| R-HSA-9664407 | Parasite infection | 0.890765 | 0.050 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.890765 | 0.050 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.892302 | 0.049 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.896786 | 0.047 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.898809 | 0.046 |
| R-HSA-5688426 | Deubiquitination | 0.899562 | 0.046 |
| R-HSA-2187338 | Visual phototransduction | 0.902477 | 0.045 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.909153 | 0.041 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.909153 | 0.041 |
| R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 0.915373 | 0.038 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.918900 | 0.037 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.923376 | 0.035 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.929359 | 0.032 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.933519 | 0.030 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.933519 | 0.030 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.934251 | 0.030 |
| R-HSA-8978868 | Fatty acid metabolism | 0.940701 | 0.027 |
| R-HSA-597592 | Post-translational protein modification | 0.943856 | 0.025 |
| R-HSA-375276 | Peptide ligand-binding receptors | 0.944733 | 0.025 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.948401 | 0.023 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 0.949969 | 0.022 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.950675 | 0.022 |
| R-HSA-72766 | Translation | 0.952889 | 0.021 |
| R-HSA-428157 | Sphingolipid metabolism | 0.955350 | 0.020 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.956603 | 0.019 |
| R-HSA-9640148 | Infection with Enterobacteria | 0.956603 | 0.019 |
| R-HSA-72172 | mRNA Splicing | 0.957821 | 0.019 |
| R-HSA-397014 | Muscle contraction | 0.962361 | 0.017 |
| R-HSA-8951664 | Neddylation | 0.966890 | 0.015 |
| R-HSA-392499 | Metabolism of proteins | 0.967159 | 0.015 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.970458 | 0.013 |
| R-HSA-5663205 | Infectious disease | 0.972794 | 0.012 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.973642 | 0.012 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 0.974384 | 0.011 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.983068 | 0.007 |
| R-HSA-418594 | G alpha (i) signalling events | 0.983724 | 0.007 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.984460 | 0.007 |
| R-HSA-195721 | Signaling by WNT | 0.988976 | 0.005 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.997263 | 0.001 |
| R-HSA-382551 | Transport of small molecules | 0.998647 | 0.001 |
| R-HSA-1430728 | Metabolism | 0.998675 | 0.001 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.998903 | 0.000 |
| R-HSA-112316 | Neuronal System | 0.999060 | 0.000 |
| R-HSA-388396 | GPCR downstream signalling | 0.999127 | 0.000 |
| R-HSA-211859 | Biological oxidations | 0.999576 | 0.000 |
| R-HSA-372790 | Signaling by GPCR | 0.999690 | 0.000 |
| R-HSA-500792 | GPCR ligand binding | 0.999838 | 0.000 |
| R-HSA-109582 | Hemostasis | 0.999881 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999986 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CDK19 |
0.855 | 0.638 | 1 | 0.949 |
JNK2 |
0.854 | 0.730 | 1 | 0.950 |
CDK8 |
0.853 | 0.635 | 1 | 0.936 |
CDK18 |
0.851 | 0.648 | 1 | 0.938 |
CDK17 |
0.850 | 0.665 | 1 | 0.945 |
P38G |
0.849 | 0.690 | 1 | 0.952 |
KIS |
0.849 | 0.556 | 1 | 0.920 |
P38D |
0.847 | 0.712 | 1 | 0.951 |
CDK3 |
0.847 | 0.601 | 1 | 0.946 |
CDK7 |
0.846 | 0.632 | 1 | 0.933 |
CDK16 |
0.846 | 0.651 | 1 | 0.940 |
JNK3 |
0.845 | 0.714 | 1 | 0.938 |
CDK1 |
0.845 | 0.635 | 1 | 0.938 |
P38B |
0.845 | 0.668 | 1 | 0.921 |
CDK5 |
0.844 | 0.625 | 1 | 0.914 |
CDK13 |
0.844 | 0.642 | 1 | 0.938 |
ERK1 |
0.843 | 0.655 | 1 | 0.927 |
NLK |
0.841 | 0.645 | 1 | 0.772 |
P38A |
0.839 | 0.646 | 1 | 0.887 |
CDK12 |
0.838 | 0.632 | 1 | 0.945 |
HIPK2 |
0.837 | 0.559 | 1 | 0.932 |
CDK9 |
0.836 | 0.627 | 1 | 0.933 |
DYRK2 |
0.836 | 0.562 | 1 | 0.900 |
ERK2 |
0.836 | 0.676 | 1 | 0.905 |
ERK5 |
0.835 | 0.446 | 1 | 0.674 |
CDK14 |
0.834 | 0.636 | 1 | 0.924 |
CLK3 |
0.833 | 0.343 | 1 | 0.737 |
CDK2 |
0.833 | 0.528 | 1 | 0.870 |
CDK10 |
0.829 | 0.595 | 1 | 0.929 |
HIPK4 |
0.828 | 0.334 | 1 | 0.749 |
CDK4 |
0.828 | 0.647 | 1 | 0.948 |
CDK6 |
0.826 | 0.626 | 1 | 0.927 |
DYRK4 |
0.826 | 0.568 | 1 | 0.950 |
HIPK1 |
0.825 | 0.510 | 1 | 0.888 |
DYRK1B |
0.825 | 0.548 | 1 | 0.919 |
JNK1 |
0.825 | 0.648 | 1 | 0.943 |
SRPK1 |
0.821 | 0.223 | -3 | 0.659 |
COT |
0.819 | -0.052 | 2 | 0.901 |
HIPK3 |
0.818 | 0.492 | 1 | 0.860 |
DYRK1A |
0.818 | 0.435 | 1 | 0.877 |
CLK1 |
0.815 | 0.286 | -3 | 0.659 |
MTOR |
0.813 | 0.098 | 1 | 0.579 |
SRPK2 |
0.811 | 0.165 | -3 | 0.574 |
CLK4 |
0.811 | 0.252 | -3 | 0.676 |
ICK |
0.811 | 0.221 | -3 | 0.761 |
DYRK3 |
0.810 | 0.390 | 1 | 0.861 |
PRP4 |
0.810 | 0.367 | -3 | 0.758 |
CDKL5 |
0.809 | 0.090 | -3 | 0.710 |
PRPK |
0.809 | -0.081 | -1 | 0.870 |
CDC7 |
0.809 | -0.058 | 1 | 0.456 |
PRKD1 |
0.808 | -0.004 | -3 | 0.764 |
ULK2 |
0.807 | -0.122 | 2 | 0.823 |
TBK1 |
0.807 | -0.126 | 1 | 0.400 |
CDKL1 |
0.807 | 0.067 | -3 | 0.719 |
IKKE |
0.806 | -0.100 | 1 | 0.397 |
CLK2 |
0.806 | 0.270 | -3 | 0.661 |
DSTYK |
0.805 | -0.071 | 2 | 0.899 |
PRKD2 |
0.804 | -0.003 | -3 | 0.694 |
IKKB |
0.804 | -0.105 | -2 | 0.586 |
GCN2 |
0.803 | -0.184 | 2 | 0.825 |
PDHK4 |
0.802 | -0.146 | 1 | 0.507 |
MOS |
0.802 | -0.082 | 1 | 0.499 |
CAMK1B |
0.801 | -0.063 | -3 | 0.799 |
RAF1 |
0.801 | -0.166 | 1 | 0.449 |
PDHK1 |
0.801 | -0.123 | 1 | 0.490 |
SRPK3 |
0.800 | 0.139 | -3 | 0.627 |
BMPR2 |
0.800 | -0.185 | -2 | 0.616 |
NEK6 |
0.800 | -0.089 | -2 | 0.588 |
NDR2 |
0.800 | -0.081 | -3 | 0.771 |
PIM3 |
0.799 | -0.087 | -3 | 0.760 |
MST4 |
0.799 | -0.050 | 2 | 0.848 |
CHAK2 |
0.799 | -0.044 | -1 | 0.890 |
MAK |
0.798 | 0.344 | -2 | 0.510 |
ATR |
0.798 | -0.076 | 1 | 0.479 |
MARK4 |
0.798 | -0.056 | 4 | 0.840 |
ULK1 |
0.798 | -0.125 | -3 | 0.812 |
IKKA |
0.798 | -0.039 | -2 | 0.573 |
NIK |
0.797 | -0.084 | -3 | 0.834 |
RSK2 |
0.797 | -0.029 | -3 | 0.685 |
CAMK2G |
0.797 | -0.092 | 2 | 0.841 |
WNK1 |
0.796 | -0.092 | -2 | 0.596 |
NDR1 |
0.796 | -0.088 | -3 | 0.764 |
NEK7 |
0.796 | -0.163 | -3 | 0.817 |
PKN3 |
0.796 | -0.089 | -3 | 0.758 |
TSSK2 |
0.795 | -0.053 | -5 | 0.871 |
P90RSK |
0.795 | -0.027 | -3 | 0.690 |
NUAK2 |
0.795 | -0.046 | -3 | 0.764 |
RSK3 |
0.794 | -0.041 | -3 | 0.687 |
NEK9 |
0.794 | -0.094 | 2 | 0.859 |
CAMLCK |
0.793 | -0.069 | -2 | 0.602 |
MAPKAPK3 |
0.793 | -0.065 | -3 | 0.706 |
AURC |
0.793 | -0.028 | -2 | 0.468 |
PKCD |
0.793 | -0.053 | 2 | 0.809 |
TGFBR2 |
0.793 | -0.139 | -2 | 0.521 |
NIM1 |
0.793 | -0.053 | 3 | 0.782 |
MOK |
0.793 | 0.342 | 1 | 0.786 |
TSSK1 |
0.792 | -0.050 | -3 | 0.813 |
AMPKA1 |
0.792 | -0.078 | -3 | 0.789 |
PKN2 |
0.792 | -0.090 | -3 | 0.773 |
RIPK3 |
0.791 | -0.116 | 3 | 0.756 |
PRKD3 |
0.791 | -0.022 | -3 | 0.665 |
P70S6KB |
0.790 | -0.042 | -3 | 0.719 |
DAPK2 |
0.790 | -0.091 | -3 | 0.808 |
BCKDK |
0.790 | -0.140 | -1 | 0.816 |
HUNK |
0.790 | -0.138 | 2 | 0.826 |
PAK6 |
0.790 | -0.014 | -2 | 0.532 |
PIM1 |
0.790 | -0.041 | -3 | 0.690 |
ERK7 |
0.790 | 0.211 | 2 | 0.529 |
MLK2 |
0.790 | -0.110 | 2 | 0.852 |
MLK1 |
0.790 | -0.151 | 2 | 0.829 |
MNK2 |
0.789 | -0.049 | -2 | 0.557 |
PKACG |
0.789 | -0.077 | -2 | 0.530 |
LATS2 |
0.789 | -0.082 | -5 | 0.759 |
PINK1 |
0.789 | 0.136 | 1 | 0.607 |
WNK3 |
0.788 | -0.189 | 1 | 0.438 |
CAMK2D |
0.788 | -0.112 | -3 | 0.784 |
SKMLCK |
0.788 | -0.112 | -2 | 0.574 |
IRE1 |
0.788 | -0.084 | 1 | 0.419 |
MAPKAPK2 |
0.788 | -0.050 | -3 | 0.646 |
PKR |
0.787 | -0.011 | 1 | 0.461 |
AMPKA2 |
0.786 | -0.070 | -3 | 0.749 |
GRK6 |
0.786 | -0.060 | 1 | 0.454 |
GRK1 |
0.786 | -0.073 | -2 | 0.542 |
GRK5 |
0.786 | -0.190 | -3 | 0.829 |
QSK |
0.785 | -0.049 | 4 | 0.823 |
NUAK1 |
0.785 | -0.069 | -3 | 0.716 |
MELK |
0.784 | -0.082 | -3 | 0.739 |
MASTL |
0.784 | -0.222 | -2 | 0.576 |
CHK1 |
0.784 | -0.048 | -3 | 0.778 |
NEK2 |
0.784 | -0.104 | 2 | 0.831 |
QIK |
0.783 | -0.103 | -3 | 0.774 |
VRK2 |
0.783 | 0.014 | 1 | 0.549 |
PAK3 |
0.783 | -0.102 | -2 | 0.542 |
TGFBR1 |
0.783 | -0.078 | -2 | 0.531 |
ANKRD3 |
0.783 | -0.189 | 1 | 0.465 |
DNAPK |
0.783 | -0.033 | 1 | 0.412 |
MNK1 |
0.783 | -0.041 | -2 | 0.573 |
DLK |
0.782 | -0.180 | 1 | 0.467 |
MLK3 |
0.782 | -0.081 | 2 | 0.754 |
AURB |
0.782 | -0.056 | -2 | 0.468 |
ALK4 |
0.782 | -0.093 | -2 | 0.558 |
IRE2 |
0.782 | -0.095 | 2 | 0.776 |
BMPR1B |
0.782 | -0.068 | 1 | 0.423 |
PKG2 |
0.781 | -0.054 | -2 | 0.494 |
ATM |
0.781 | -0.087 | 1 | 0.427 |
RIPK1 |
0.781 | -0.169 | 1 | 0.425 |
CAMK4 |
0.781 | -0.142 | -3 | 0.751 |
PAK1 |
0.781 | -0.091 | -2 | 0.530 |
LATS1 |
0.780 | -0.061 | -3 | 0.791 |
PKACB |
0.780 | -0.043 | -2 | 0.476 |
SMG1 |
0.780 | -0.061 | 1 | 0.446 |
MEK1 |
0.779 | -0.129 | 2 | 0.876 |
RSK4 |
0.779 | -0.032 | -3 | 0.645 |
MARK2 |
0.779 | -0.052 | 4 | 0.753 |
SIK |
0.779 | -0.076 | -3 | 0.686 |
MARK3 |
0.779 | -0.048 | 4 | 0.786 |
PHKG1 |
0.779 | -0.107 | -3 | 0.757 |
PKCB |
0.778 | -0.072 | 2 | 0.756 |
YSK4 |
0.778 | -0.169 | 1 | 0.415 |
CHAK1 |
0.778 | -0.119 | 2 | 0.790 |
MSK2 |
0.778 | -0.095 | -3 | 0.648 |
PKCA |
0.778 | -0.067 | 2 | 0.741 |
FAM20C |
0.778 | -0.012 | 2 | 0.643 |
PLK1 |
0.778 | -0.154 | -2 | 0.552 |
AKT2 |
0.778 | -0.022 | -3 | 0.589 |
PKCZ |
0.778 | -0.084 | 2 | 0.801 |
PKCG |
0.777 | -0.087 | 2 | 0.745 |
SGK3 |
0.776 | -0.061 | -3 | 0.678 |
CAMKK1 |
0.776 | 0.100 | -2 | 0.700 |
TTBK2 |
0.776 | -0.180 | 2 | 0.730 |
CAMK2B |
0.775 | -0.100 | 2 | 0.817 |
SSTK |
0.775 | -0.035 | 4 | 0.815 |
PIM2 |
0.775 | -0.034 | -3 | 0.658 |
BRSK2 |
0.774 | -0.108 | -3 | 0.753 |
CAMKK2 |
0.774 | 0.107 | -2 | 0.702 |
PKCH |
0.774 | -0.099 | 2 | 0.742 |
IRAK4 |
0.774 | -0.060 | 1 | 0.409 |
MSK1 |
0.774 | -0.077 | -3 | 0.661 |
BRAF |
0.774 | -0.078 | -4 | 0.820 |
MPSK1 |
0.774 | 0.008 | 1 | 0.465 |
CAMK2A |
0.773 | -0.085 | 2 | 0.818 |
PHKG2 |
0.773 | -0.069 | -3 | 0.732 |
MEKK1 |
0.773 | -0.106 | 1 | 0.457 |
PRKX |
0.773 | -0.029 | -3 | 0.576 |
ZAK |
0.773 | -0.117 | 1 | 0.439 |
MARK1 |
0.773 | -0.079 | 4 | 0.802 |
BRSK1 |
0.773 | -0.101 | -3 | 0.720 |
MLK4 |
0.773 | -0.124 | 2 | 0.746 |
AKT1 |
0.772 | -0.019 | -3 | 0.611 |
ALK2 |
0.772 | -0.095 | -2 | 0.551 |
ACVR2A |
0.772 | -0.129 | -2 | 0.524 |
ACVR2B |
0.771 | -0.124 | -2 | 0.537 |
PAK2 |
0.771 | -0.124 | -2 | 0.526 |
MAPKAPK5 |
0.771 | -0.106 | -3 | 0.635 |
GRK4 |
0.771 | -0.217 | -2 | 0.539 |
MYLK4 |
0.771 | -0.096 | -2 | 0.536 |
PLK4 |
0.771 | -0.144 | 2 | 0.675 |
PERK |
0.770 | -0.148 | -2 | 0.593 |
HRI |
0.770 | -0.172 | -2 | 0.580 |
AURA |
0.770 | -0.080 | -2 | 0.438 |
PLK3 |
0.769 | -0.130 | 2 | 0.793 |
TLK2 |
0.769 | -0.173 | 1 | 0.426 |
NEK5 |
0.769 | -0.106 | 1 | 0.433 |
MEK5 |
0.769 | -0.164 | 2 | 0.858 |
GRK7 |
0.768 | -0.085 | 1 | 0.442 |
LKB1 |
0.768 | 0.088 | -3 | 0.815 |
PKACA |
0.768 | -0.053 | -2 | 0.456 |
PKCT |
0.768 | -0.086 | 2 | 0.758 |
WNK4 |
0.768 | -0.137 | -2 | 0.594 |
DCAMKL1 |
0.768 | -0.093 | -3 | 0.711 |
CAMK1G |
0.768 | -0.096 | -3 | 0.677 |
MEKK2 |
0.768 | -0.127 | 2 | 0.842 |
GSK3A |
0.768 | 0.099 | 4 | 0.367 |
SNRK |
0.767 | -0.175 | 2 | 0.725 |
MST3 |
0.767 | -0.078 | 2 | 0.831 |
PKCI |
0.767 | -0.055 | 2 | 0.759 |
PAK5 |
0.766 | -0.073 | -2 | 0.458 |
GRK2 |
0.766 | -0.114 | -2 | 0.485 |
P70S6K |
0.765 | -0.053 | -3 | 0.619 |
BMPR1A |
0.765 | -0.085 | 1 | 0.413 |
TAO3 |
0.765 | -0.091 | 1 | 0.459 |
DCAMKL2 |
0.764 | -0.083 | -3 | 0.741 |
SMMLCK |
0.764 | -0.092 | -3 | 0.744 |
DRAK1 |
0.764 | -0.161 | 1 | 0.386 |
MEKK3 |
0.763 | -0.189 | 1 | 0.446 |
TAO2 |
0.763 | -0.070 | 2 | 0.864 |
NEK4 |
0.763 | -0.046 | 1 | 0.416 |
PAK4 |
0.762 | -0.066 | -2 | 0.458 |
IRAK1 |
0.762 | -0.113 | -1 | 0.770 |
TLK1 |
0.761 | -0.184 | -2 | 0.529 |
HGK |
0.760 | -0.058 | 3 | 0.882 |
GAK |
0.760 | -0.045 | 1 | 0.479 |
AKT3 |
0.759 | -0.026 | -3 | 0.518 |
SBK |
0.759 | 0.048 | -3 | 0.466 |
PKN1 |
0.759 | -0.069 | -3 | 0.638 |
BUB1 |
0.759 | 0.024 | -5 | 0.811 |
LOK |
0.759 | -0.072 | -2 | 0.582 |
GSK3B |
0.759 | -0.009 | 4 | 0.354 |
CAMK1D |
0.758 | -0.082 | -3 | 0.596 |
TNIK |
0.758 | -0.053 | 3 | 0.882 |
NEK11 |
0.758 | -0.146 | 1 | 0.452 |
TTBK1 |
0.757 | -0.110 | 2 | 0.644 |
NEK8 |
0.757 | -0.134 | 2 | 0.834 |
NEK1 |
0.757 | -0.036 | 1 | 0.414 |
PKCE |
0.756 | -0.052 | 2 | 0.723 |
PBK |
0.756 | -0.015 | 1 | 0.431 |
MINK |
0.756 | -0.097 | 1 | 0.421 |
MEKK6 |
0.756 | -0.102 | 1 | 0.444 |
PDK1 |
0.756 | -0.094 | 1 | 0.452 |
MAP3K15 |
0.755 | -0.103 | 1 | 0.434 |
MST2 |
0.755 | -0.145 | 1 | 0.439 |
LRRK2 |
0.755 | -0.048 | 2 | 0.860 |
GCK |
0.754 | -0.115 | 1 | 0.443 |
NEK3 |
0.753 | -0.049 | 1 | 0.426 |
CK1E |
0.752 | -0.086 | -3 | 0.485 |
EEF2K |
0.752 | -0.090 | 3 | 0.854 |
MRCKB |
0.752 | -0.053 | -3 | 0.653 |
PASK |
0.752 | -0.116 | -3 | 0.774 |
DAPK3 |
0.751 | -0.097 | -3 | 0.718 |
SGK1 |
0.751 | -0.036 | -3 | 0.500 |
MRCKA |
0.751 | -0.061 | -3 | 0.671 |
SLK |
0.751 | -0.092 | -2 | 0.526 |
MST1 |
0.750 | -0.136 | 1 | 0.423 |
KHS1 |
0.750 | -0.070 | 1 | 0.429 |
CAMK1A |
0.750 | -0.069 | -3 | 0.562 |
YSK1 |
0.750 | -0.091 | 2 | 0.823 |
CHK2 |
0.749 | -0.064 | -3 | 0.536 |
BIKE |
0.749 | -0.004 | 1 | 0.423 |
HPK1 |
0.749 | -0.105 | 1 | 0.434 |
CK2A2 |
0.748 | -0.075 | 1 | 0.373 |
MEK2 |
0.748 | -0.161 | 2 | 0.857 |
ROCK2 |
0.747 | -0.062 | -3 | 0.707 |
TAK1 |
0.747 | -0.157 | 1 | 0.433 |
RIPK2 |
0.746 | -0.163 | 1 | 0.402 |
KHS2 |
0.746 | -0.054 | 1 | 0.442 |
DMPK1 |
0.746 | -0.024 | -3 | 0.671 |
VRK1 |
0.746 | -0.177 | 2 | 0.867 |
CK1D |
0.746 | -0.062 | -3 | 0.437 |
PKG1 |
0.745 | -0.082 | -2 | 0.432 |
GRK3 |
0.745 | -0.131 | -2 | 0.439 |
PDHK3_TYR |
0.745 | 0.145 | 4 | 0.868 |
STK33 |
0.744 | -0.122 | 2 | 0.632 |
CK1G1 |
0.743 | -0.105 | -3 | 0.489 |
AAK1 |
0.743 | 0.025 | 1 | 0.383 |
DAPK1 |
0.742 | -0.107 | -3 | 0.692 |
PLK2 |
0.742 | -0.065 | -3 | 0.798 |
HASPIN |
0.741 | -0.020 | -1 | 0.734 |
CK1A2 |
0.740 | -0.079 | -3 | 0.427 |
ROCK1 |
0.737 | -0.066 | -3 | 0.670 |
CK2A1 |
0.737 | -0.088 | 1 | 0.358 |
MYO3B |
0.737 | -0.074 | 2 | 0.833 |
CRIK |
0.737 | -0.032 | -3 | 0.605 |
LIMK2_TYR |
0.737 | 0.075 | -3 | 0.864 |
OSR1 |
0.736 | -0.108 | 2 | 0.835 |
TESK1_TYR |
0.736 | -0.003 | 3 | 0.886 |
TAO1 |
0.736 | -0.089 | 1 | 0.410 |
PKMYT1_TYR |
0.735 | 0.038 | 3 | 0.861 |
ASK1 |
0.734 | -0.105 | 1 | 0.430 |
MYO3A |
0.734 | -0.096 | 1 | 0.434 |
TTK |
0.733 | -0.129 | -2 | 0.528 |
MAP2K4_TYR |
0.730 | -0.051 | -1 | 0.890 |
PDHK4_TYR |
0.730 | 0.003 | 2 | 0.896 |
MAP2K7_TYR |
0.729 | -0.146 | 2 | 0.882 |
BMPR2_TYR |
0.729 | -0.011 | -1 | 0.876 |
MAP2K6_TYR |
0.728 | -0.051 | -1 | 0.899 |
LIMK1_TYR |
0.727 | -0.041 | 2 | 0.879 |
PINK1_TYR |
0.725 | -0.146 | 1 | 0.489 |
EPHA6 |
0.724 | -0.053 | -1 | 0.860 |
JAK2 |
0.724 | -0.076 | 1 | 0.466 |
RET |
0.724 | -0.138 | 1 | 0.457 |
TYK2 |
0.723 | -0.126 | 1 | 0.445 |
MST1R |
0.722 | -0.104 | 3 | 0.832 |
ALPHAK3 |
0.722 | -0.094 | -1 | 0.798 |
STLK3 |
0.722 | -0.153 | 1 | 0.413 |
ROS1 |
0.721 | -0.111 | 3 | 0.797 |
TNNI3K_TYR |
0.721 | -0.022 | 1 | 0.495 |
CSF1R |
0.721 | -0.081 | 3 | 0.811 |
PDHK1_TYR |
0.720 | -0.158 | -1 | 0.900 |
TYRO3 |
0.719 | -0.140 | 3 | 0.822 |
NEK10_TYR |
0.718 | -0.074 | 1 | 0.375 |
JAK3 |
0.717 | -0.107 | 1 | 0.444 |
DDR1 |
0.717 | -0.125 | 4 | 0.807 |
EPHB4 |
0.716 | -0.125 | -1 | 0.838 |
YANK3 |
0.715 | -0.072 | 2 | 0.401 |
JAK1 |
0.715 | -0.065 | 1 | 0.421 |
ABL2 |
0.714 | -0.105 | -1 | 0.826 |
FGFR1 |
0.714 | -0.043 | 3 | 0.778 |
FGFR2 |
0.714 | -0.062 | 3 | 0.795 |
TNK1 |
0.714 | -0.084 | 3 | 0.796 |
TEK |
0.714 | -0.026 | 3 | 0.754 |
ABL1 |
0.712 | -0.099 | -1 | 0.816 |
PDGFRB |
0.712 | -0.148 | 3 | 0.834 |
YES1 |
0.711 | -0.125 | -1 | 0.841 |
TXK |
0.711 | -0.109 | 1 | 0.445 |
FER |
0.710 | -0.167 | 1 | 0.464 |
FGR |
0.710 | -0.182 | 1 | 0.444 |
INSRR |
0.709 | -0.146 | 3 | 0.758 |
KDR |
0.708 | -0.108 | 3 | 0.776 |
FLT3 |
0.708 | -0.143 | 3 | 0.822 |
EPHA4 |
0.708 | -0.088 | 2 | 0.776 |
TNK2 |
0.707 | -0.134 | 3 | 0.782 |
HCK |
0.707 | -0.135 | -1 | 0.811 |
ITK |
0.707 | -0.133 | -1 | 0.793 |
KIT |
0.707 | -0.131 | 3 | 0.813 |
PDGFRA |
0.706 | -0.156 | 3 | 0.833 |
EPHB1 |
0.705 | -0.156 | 1 | 0.446 |
SRMS |
0.705 | -0.166 | 1 | 0.443 |
LCK |
0.705 | -0.122 | -1 | 0.811 |
EPHB3 |
0.702 | -0.163 | -1 | 0.817 |
AXL |
0.702 | -0.170 | 3 | 0.783 |
DDR2 |
0.702 | -0.068 | 3 | 0.754 |
ALK |
0.702 | -0.130 | 3 | 0.754 |
BLK |
0.702 | -0.116 | -1 | 0.823 |
MERTK |
0.701 | -0.157 | 3 | 0.777 |
EPHB2 |
0.701 | -0.154 | -1 | 0.811 |
FGFR3 |
0.701 | -0.081 | 3 | 0.767 |
WEE1_TYR |
0.700 | -0.096 | -1 | 0.745 |
BTK |
0.700 | -0.152 | -1 | 0.754 |
MET |
0.699 | -0.148 | 3 | 0.805 |
LTK |
0.699 | -0.141 | 3 | 0.770 |
TEC |
0.698 | -0.142 | -1 | 0.726 |
BMX |
0.697 | -0.131 | -1 | 0.708 |
CK1A |
0.697 | -0.110 | -3 | 0.347 |
EPHA1 |
0.697 | -0.152 | 3 | 0.784 |
INSR |
0.696 | -0.141 | 3 | 0.733 |
NTRK2 |
0.696 | -0.168 | 3 | 0.772 |
EPHA7 |
0.696 | -0.134 | 2 | 0.787 |
NTRK1 |
0.696 | -0.180 | -1 | 0.827 |
FLT4 |
0.696 | -0.140 | 3 | 0.755 |
ERBB2 |
0.695 | -0.161 | 1 | 0.427 |
FRK |
0.694 | -0.146 | -1 | 0.823 |
PTK2B |
0.693 | -0.098 | -1 | 0.765 |
FLT1 |
0.693 | -0.162 | -1 | 0.847 |
EPHA3 |
0.693 | -0.134 | 2 | 0.758 |
PTK6 |
0.693 | -0.202 | -1 | 0.733 |
EGFR |
0.692 | -0.105 | 1 | 0.384 |
NTRK3 |
0.691 | -0.152 | -1 | 0.775 |
FYN |
0.691 | -0.126 | -1 | 0.779 |
MATK |
0.691 | -0.116 | -1 | 0.762 |
LYN |
0.689 | -0.144 | 3 | 0.737 |
MUSK |
0.688 | -0.112 | 1 | 0.352 |
EPHA8 |
0.686 | -0.135 | -1 | 0.800 |
EPHA5 |
0.685 | -0.154 | 2 | 0.774 |
YANK2 |
0.684 | -0.084 | 2 | 0.419 |
FGFR4 |
0.683 | -0.117 | -1 | 0.782 |
SRC |
0.683 | -0.144 | -1 | 0.787 |
CSK |
0.682 | -0.163 | 2 | 0.791 |
PTK2 |
0.679 | -0.086 | -1 | 0.785 |
CK1G3 |
0.678 | -0.102 | -3 | 0.298 |
SYK |
0.677 | -0.118 | -1 | 0.769 |
IGF1R |
0.676 | -0.149 | 3 | 0.673 |
EPHA2 |
0.676 | -0.135 | -1 | 0.767 |
ERBB4 |
0.676 | -0.110 | 1 | 0.395 |
FES |
0.667 | -0.124 | -1 | 0.686 |
ZAP70 |
0.659 | -0.109 | -1 | 0.700 |
CK1G2 |
0.657 | -0.120 | -3 | 0.400 |