Motif 835 (n=160)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A4UGR9 | XIRP2 | S3059 | ochoa | Xin actin-binding repeat-containing protein 2 (Beta-xin) (Cardiomyopathy-associated protein 3) (Xeplin) | Protects actin filaments from depolymerization (PubMed:15454575). Required for correct morphology of cell membranes and maturation of intercalated disks of cardiomyocytes via facilitating localization of XIRP1 and CDH2 to the termini of aligned mature cardiomyocytes (By similarity). Thereby required for correct postnatal heart development and growth regulation that is crucial for overall heart morphology and diastolic function (By similarity). Required for normal electrical conduction in the heart including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with the cardiac ion channel components Scn5a/Nav1.5 and Kcna5/Kv1.5 (By similarity). Required for regular actin filament spacing of the paracrystalline array in both inner and outer hair cells of the cochlea, thereby required for maintenance of stereocilia morphology (By similarity). {ECO:0000250|UniProtKB:Q4U4S6, ECO:0000269|PubMed:15454575}. |
| A5YKK6 | CNOT1 | S1703 | ochoa | CCR4-NOT transcription complex subunit 1 (CCR4-associated factor 1) (Negative regulator of transcription subunit 1 homolog) (NOT1H) (hNOT1) | Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of embryonic stem (ES) cell identity. Plays a role in rapid sperm motility via mediating timely mRNA turnover (By similarity). {ECO:0000250|UniProtKB:Q6ZQ08, ECO:0000269|PubMed:10637334, ECO:0000269|PubMed:16778766, ECO:0000269|PubMed:21278420, ECO:0000269|PubMed:21976065, ECO:0000269|PubMed:21984185, ECO:0000269|PubMed:22367759, ECO:0000269|PubMed:23644599, ECO:0000269|PubMed:27558897, ECO:0000269|PubMed:32354837}. |
| A6NGC4 | TLCD2 | S235 | ochoa | TLC domain-containing protein 2 | Regulates the composition and fluidity of the plasma membrane (PubMed:30509349). Inhibits the incorporation of membrane-fluidizing phospholipids containing omega-3 long-chain polyunsaturated fatty acids (LCPUFA) and thereby promotes membrane rigidity (PubMed:30509349). Does not appear to have any effect on LCPUFA synthesis (PubMed:30509349). {ECO:0000269|PubMed:30509349}. |
| A8MYZ6 | FOXO6 | S275 | ochoa | Forkhead box protein O6 | Transcriptional activator. {ECO:0000250}. |
| O00482 | NR5A2 | S243 | psp | Nuclear receptor subfamily 5 group A member 2 (Alpha-1-fetoprotein transcription factor) (B1-binding factor) (hB1F) (CYP7A promoter-binding factor) (Hepatocytic transcription factor) (Liver receptor homolog 1) (LRH-1) | Orphan nuclear receptor that binds DNA as a monomer to the 5'-TCAAGGCCA-3' sequence and controls expression of target genes: regulates key biological processes, such as early embryonic development, cholesterol and bile acid synthesis pathways, as well as liver and pancreas morphogenesis (PubMed:16289203, PubMed:18410128, PubMed:21614002, PubMed:32433991, PubMed:38409506, PubMed:9786908). Ligand-binding causes conformational change which causes recruitment of coactivators, promoting target gene activation (PubMed:21614002). The specific ligand is unknown, but specific phospholipids, such as phosphatidylethanolamine, phosphatidylserine, dilauroyl phosphatidylcholine and diundecanoyl phosphatidylcholine can act as ligand in vitro (PubMed:15707893, PubMed:15723037, PubMed:15897460, PubMed:21614002, PubMed:22504882, PubMed:23737522, PubMed:26416531, PubMed:26553876). Acts as a pioneer transcription factor, which unwraps target DNA from histones and elicits local opening of closed chromatin (PubMed:38409506). Plays a central role during preimplantation stages of embryonic development (By similarity). Plays a minor role in zygotic genome activation (ZGA) by regulating a small set of two-cell stage genes (By similarity). Plays a major role in morula development (2-16 cells embryos) by acting as a master regulator at the 8-cell stage, controlling expression of lineage-specifying transcription factors and genes involved in mitosis, telomere maintenance and DNA repair (By similarity). Zygotic NR5A2 binds to both closed and open chromatin with other transcription factors, often at SINE B1/Alu repeats DNA elements, promoting chromatin accessibility at nearby regulatory regions (By similarity). Also involved in the epiblast stage of development and embryonic stem cell pluripotency, by promoting expression of POU5F1/OCT4 (PubMed:27984042). Regulates other processes later in development, such as formation of connective tissue in lower jaw and middle ear, neural stem cell differentiation, ovarian follicle development and Sertoli cell differentiation (By similarity). Involved in exocrine pancreas development and acinar cell differentiation (By similarity). Acts as an essential transcriptional regulator of lipid metabolism (PubMed:20159957). Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver (PubMed:10359768). Also acts as a negative regulator of inflammation in different organs, such as, liver and pancreas (PubMed:20159957). Protects against intestinal inflammation via its ability to regulate glucocorticoid production (By similarity). Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (PubMed:20159957). Acts as a regulator of immunity by promoting lymphocyte T-cell development, proliferation and effector functions (By similarity). Also involved in resolution of endoplasmic reticulum stress in the liver (By similarity). {ECO:0000250|UniProtKB:P45448, ECO:0000269|PubMed:10359768, ECO:0000269|PubMed:15707893, ECO:0000269|PubMed:15723037, ECO:0000269|PubMed:15897460, ECO:0000269|PubMed:16289203, ECO:0000269|PubMed:18410128, ECO:0000269|PubMed:20159957, ECO:0000269|PubMed:21614002, ECO:0000269|PubMed:22504882, ECO:0000269|PubMed:23737522, ECO:0000269|PubMed:26416531, ECO:0000269|PubMed:26553876, ECO:0000269|PubMed:27984042, ECO:0000269|PubMed:32433991, ECO:0000269|PubMed:38409506, ECO:0000269|PubMed:9786908}.; FUNCTION: [Isoform 3]: In constrast to isoform 1 and isoform 2, does not induce cholesterol 7-alpha-hydroxylase gene (CYP7A) promoter activity. {ECO:0000269|PubMed:10359768}.; FUNCTION: (Microbial infection) Plays a crucial role for hepatitis B virus gene transcription and DNA replication. Mechanistically, synergistically cooperates with HNF1A to up-regulate the activity of one of the critical cis-elements in the hepatitis B virus genome enhancer II (ENII). {ECO:0000269|PubMed:14728801, ECO:0000269|PubMed:9786908}. |
| O00763 | ACACB | S246 | ochoa | Acetyl-CoA carboxylase 2 (EC 6.4.1.2) (ACC-beta) | Mitochondrial enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA and plays a central role in fatty acid metabolism (PubMed:16854592, PubMed:19236960, PubMed:19900410, PubMed:20457939, PubMed:20952656, PubMed:26976583). Catalyzes a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:19236960, PubMed:20457939, PubMed:20952656, PubMed:26976583). Through the production of malonyl-CoA that allosterically inhibits carnitine palmitoyltransferase 1 at the mitochondria, negatively regulates fatty acid oxidation (By similarity). Together with its cytosolic isozyme ACACA, which is involved in de novo fatty acid biosynthesis, promotes lipid storage (By similarity). {ECO:0000250|UniProtKB:E9Q4Z2, ECO:0000269|PubMed:16854592, ECO:0000269|PubMed:19236960, ECO:0000269|PubMed:19900410, ECO:0000269|PubMed:20457939, ECO:0000269|PubMed:20952656, ECO:0000269|PubMed:26976583}. |
| O14490 | DLGAP1 | S397 | ochoa | Disks large-associated protein 1 (DAP-1) (Guanylate kinase-associated protein) (hGKAP) (PSD-95/SAP90-binding protein 1) (SAP90/PSD-95-associated protein 1) (SAPAP1) | Part of the postsynaptic scaffold in neuronal cells. |
| O14607 | UTY | S716 | ochoa | Histone demethylase UTY (EC 1.14.11.68) (Ubiquitously-transcribed TPR protein on the Y chromosome) (Ubiquitously-transcribed Y chromosome tetratricopeptide repeat protein) ([histone H3]-trimethyl-L-lysine(27) demethylase UTY) | Male-specific histone demethylase that catalyzes trimethylated 'Lys-27' (H3K27me3) demethylation in histone H3. Has relatively low lysine demethylase activity. {ECO:0000269|PubMed:24798337}. |
| O14939 | PLD2 | S888 | ochoa | Phospholipase D2 (PLD 2) (hPLD2) (EC 3.1.4.4) (Choline phosphatase 2) (PLD1C) (Phosphatidylcholine-hydrolyzing phospholipase D2) | Function as phospholipase selective for phosphatidylcholine (PubMed:9582313). May have a role in signal-induced cytoskeletal regulation and/or endocytosis (By similarity). {ECO:0000250|UniProtKB:P97813, ECO:0000269|PubMed:9582313}. |
| O15015 | ZNF646 | S230 | ochoa | Zinc finger protein 646 | May be involved in transcriptional regulation. |
| O15417 | TNRC18 | S2292 | ochoa | Trinucleotide repeat-containing gene 18 protein (Long CAG trinucleotide repeat-containing gene 79 protein) | None |
| O43379 | WDR62 | S1405 | ochoa | WD repeat-containing protein 62 | Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (PubMed:20729831, PubMed:20890278). Plays a role in mother-centriole-dependent centriole duplication; the function also seems to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). {ECO:0000269|PubMed:20729831, ECO:0000269|PubMed:20890278, ECO:0000269|PubMed:26297806}. |
| O43678 | NDUFA2 | S27 | ochoa | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (Complex I-B8) (CI-B8) (NADH-ubiquinone oxidoreductase B8 subunit) | Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}. |
| O60285 | NUAK1 | S455 | ochoa | NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5) (ARK5) (Omphalocele kinase 1) | Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in DNA damage response: phosphorylates p53/TP53 at 'Ser-15' and 'Ser-392' and is recruited to the CDKN1A/WAF1 promoter to participate in transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with STK11, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (PubMed:25329316). {ECO:0000269|PubMed:12409306, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15060171, ECO:0000269|PubMed:15273717, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:20354225, ECO:0000269|PubMed:21317932, ECO:0000269|PubMed:25329316}. |
| O60292 | SIPA1L3 | S1559 | ochoa | Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) | Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269|PubMed:26231217}. |
| O60566 | BUB1B | S720 | ochoa|psp | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1) | Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. {ECO:0000269|PubMed:10477750, ECO:0000269|PubMed:11702782, ECO:0000269|PubMed:14706340, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:19411850, ECO:0000269|PubMed:19503101}. |
| O75132 | ZBED4 | S624 | ochoa | Zinc finger BED domain-containing protein 4 | Transcriptional regulator that binds to poly-guanine tracts in gene promoters and activates transcription (By similarity). Able to bind single- and double-stranded DNA and RNA (By similarity). {ECO:0000250|UniProtKB:Q80WQ9}. |
| O75928 | PIAS2 | S50 | ochoa | E3 SUMO-protein ligase PIAS2 (EC 2.3.2.-) (Androgen receptor-interacting protein 3) (ARIP3) (DAB2-interacting protein) (DIP) (E3 SUMO-protein transferase PIAS2) (Msx-interacting zinc finger protein) (Miz1) (PIAS-NY protein) (Protein inhibitor of activated STAT x) (Protein inhibitor of activated STAT2) | Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIAS2-beta, but not isoform PIAS2-alpha, promotes MDM2 sumoylation. Isoform PIAS2-alpha promotes PARK7 sumoylation. Isoform PIAS2-beta promotes NCOA2 sumoylation more efficiently than isoform PIAS2-alpha. Isoform PIAS2-alpha sumoylates PML at'Lys-65' and 'Lys-160'. {ECO:0000269|PubMed:15920481, ECO:0000269|PubMed:15976810, ECO:0000269|PubMed:22406621}. |
| O94913 | PCF11 | S1520 | ochoa | Pre-mRNA cleavage complex 2 protein Pcf11 (Pre-mRNA cleavage complex II protein Pcf11) | Component of pre-mRNA cleavage complex II, which promotes transcription termination by RNA polymerase II. {ECO:0000269|PubMed:11060040, ECO:0000269|PubMed:29196535}. |
| O94915 | FRYL | S1258 | ochoa | Protein furry homolog-like (ALL1-fused gene from chromosome 4p12 protein) | Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching (By similarity). May function as a transcriptional activator. {ECO:0000250, ECO:0000269|PubMed:16061630}. |
| O94979 | SEC31A | S251 | ochoa | Protein transport protein Sec31A (ABP125) (ABP130) (SEC31-like protein 1) (SEC31-related protein A) (Web1-like protein) | Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER) (PubMed:10788476). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). {ECO:0000250|UniProtKB:Q9Z2Q1, ECO:0000269|PubMed:10788476}. |
| O95613 | PCNT | S610 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| O95714 | HERC2 | S368 | ochoa | E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2) | E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). Also modulates iron metabolism by regulating the basal turnover of FBXL5 (PubMed:24778179). {ECO:0000269|PubMed:20023648, ECO:0000269|PubMed:20304803, ECO:0000269|PubMed:22508508, ECO:0000269|PubMed:24778179, ECO:0000269|PubMed:26692333}. |
| O95789 | ZMYM6 | S730 | ochoa | Zinc finger MYM-type protein 6 (Transposon-derived Buster2 transposase-like protein) (Zinc finger protein 258) | Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}. |
| P11532 | DMD | S2437 | ochoa | Dystrophin | Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission. {ECO:0000250|UniProtKB:P11531, ECO:0000269|PubMed:16710609}. |
| P13796 | LCP1 | S265 | ochoa | Plastin-2 (L-plastin) (LC64P) (Lymphocyte cytosolic protein 1) (LCP-1) | Actin-binding protein (PubMed:16636079, PubMed:17294403, PubMed:28493397). Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28 (PubMed:17294403). Modulates the cell surface expression of IL2RA/CD25 and CD69 (PubMed:17294403). {ECO:0000269|PubMed:16636079, ECO:0000269|PubMed:17294403, ECO:0000269|PubMed:28493397}. |
| P13804 | ETFA | S140 | ochoa | Electron transfer flavoprotein subunit alpha, mitochondrial (Alpha-ETF) | Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase (PubMed:10356313, PubMed:15159392, PubMed:15975918, PubMed:27499296, PubMed:9334218). It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (PubMed:9334218). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism (PubMed:12815589, PubMed:1430199, PubMed:1882842). {ECO:0000269|PubMed:10356313, ECO:0000269|PubMed:12815589, ECO:0000269|PubMed:1430199, ECO:0000269|PubMed:15159392, ECO:0000269|PubMed:15975918, ECO:0000269|PubMed:27499296, ECO:0000269|PubMed:9334218, ECO:0000303|PubMed:17941859, ECO:0000305|PubMed:1882842}. |
| P16144 | ITGB4 | S1084 | ochoa | Integrin beta-4 (GP150) (CD antigen CD104) | Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:28873464}. |
| P17861 | XBP1 | S68 | ochoa|psp | X-box-binding protein 1 (XBP-1) (Tax-responsive element-binding protein 5) (TREB-5) [Cleaved into: X-box-binding protein 1, cytoplasmic form; X-box-binding protein 1, luminal form] | Functions as a transcription factor during endoplasmic reticulum (ER) stress by regulating the unfolded protein response (UPR). Required for cardiac myogenesis and hepatogenesis during embryonic development, and the development of secretory tissues such as exocrine pancreas and salivary gland (By similarity). Involved in terminal differentiation of B lymphocytes to plasma cells and production of immunoglobulins (PubMed:11460154). Modulates the cellular response to ER stress in a PIK3R-dependent manner (PubMed:20348923). Binds to the cis-acting X box present in the promoter regions of major histocompatibility complex class II genes (PubMed:8349596). Involved in VEGF-induced endothelial cell (EC) proliferation and retinal blood vessel formation during embryonic development but also for angiogenesis in adult tissues under ischemic conditions. Also functions as a major regulator of the UPR in obesity-induced insulin resistance and type 2 diabetes for the management of obesity and diabetes prevention (By similarity). {ECO:0000250|UniProtKB:O35426, ECO:0000269|PubMed:11460154, ECO:0000269|PubMed:20348923, ECO:0000269|PubMed:8349596}.; FUNCTION: [Isoform 1]: Plays a role in the unconventional cytoplasmic splicing processing of its own mRNA triggered by the endoplasmic reticulum (ER) transmembrane endoribonuclease ERN1: upon ER stress, the emerging XBP1 polypeptide chain, as part of a mRNA-ribosome-nascent chain (R-RNC) complex, cotranslationally recruits its own unprocessed mRNA through transient docking to the ER membrane and translational pausing, therefore facilitating efficient IRE1-mediated XBP1 mRNA isoform 2 production (PubMed:19394296, PubMed:21233347). In endothelial cells (EC), associated with KDR, promotes IRE1-mediated XBP1 mRNA isoform 2 productions in a vascular endothelial growth factor (VEGF)-dependent manner, leading to EC proliferation and angiogenesis (PubMed:23529610). Functions as a negative feed-back regulator of the potent transcription factor XBP1 isoform 2 protein levels through proteasome-mediated degradation, thus preventing the constitutive activation of the ER stress response signaling pathway (PubMed:16461360, PubMed:25239945). Inhibits the transactivation activity of XBP1 isoform 2 in myeloma cells (By similarity). Acts as a weak transcriptional factor (PubMed:8657566). Together with HDAC3, contributes to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to EC survival under disturbed flow/oxidative stress (PubMed:25190803). Binds to the ER stress response element (ERSE) upon ER stress (PubMed:11779464). Binds to the consensus 5'-GATGACGTG[TG]N(3)[AT]T-3' sequence related to cAMP responsive element (CRE)-like sequences (PubMed:8657566). Binds the Tax-responsive element (TRE) present in the long terminal repeat (LTR) of T-cell leukemia virus type 1 (HTLV-I) and to the TPA response elements (TRE) (PubMed:1903538, PubMed:2196176, PubMed:2321018, PubMed:8657566). Associates preferentially to the HDAC3 gene promoter region in a static flow-dependent manner (PubMed:25190803). Binds to the CDH5/VE-cadherin gene promoter region (PubMed:19416856). {ECO:0000250|UniProtKB:O35426, ECO:0000269|PubMed:11779464, ECO:0000269|PubMed:16461360, ECO:0000269|PubMed:1903538, ECO:0000269|PubMed:19394296, ECO:0000269|PubMed:19416856, ECO:0000269|PubMed:21233347, ECO:0000269|PubMed:2196176, ECO:0000269|PubMed:2321018, ECO:0000269|PubMed:23529610, ECO:0000269|PubMed:25190803, ECO:0000269|PubMed:25239945, ECO:0000269|PubMed:8657566}.; FUNCTION: [Isoform 2]: Functions as a stress-inducible potent transcriptional activator during endoplasmic reticulum (ER) stress by inducing unfolded protein response (UPR) target genes via binding to the UPR element (UPRE). Up-regulates target genes encoding ER chaperones and ER-associated degradation (ERAD) components to enhance the capacity of productive folding and degradation mechanism, respectively, in order to maintain the homeostasis of the ER under ER stress (PubMed:11779464, PubMed:25239945). Plays a role in the production of immunoglobulins and interleukin-6 in the presence of stimuli required for plasma cell differentiation (By similarity). Induces phospholipid biosynthesis and ER expansion (PubMed:15466483). Contributes to the VEGF-induced endothelial cell (EC) growth and proliferation in a Akt/GSK-dependent and/or -independent signaling pathway, respectively, leading to beta-catenin nuclear translocation and E2F2 gene expression (PubMed:23529610). Promotes umbilical vein EC apoptosis and atherosclerotisis development in a caspase-dependent signaling pathway, and contributes to VEGF-induced EC proliferation and angiogenesis in adult tissues under ischemic conditions (PubMed:19416856, PubMed:23529610). Involved in the regulation of endostatin-induced autophagy in EC through BECN1 transcriptional activation (PubMed:23184933). Plays a role as an oncogene by promoting tumor progression: stimulates zinc finger protein SNAI1 transcription to induce epithelial-to-mesenchymal (EMT) transition, cell migration and invasion of breast cancer cells (PubMed:25280941). Involved in adipocyte differentiation by regulating lipogenic gene expression during lactation. Plays a role in the survival of both dopaminergic neurons of the substantia nigra pars compacta (SNpc), by maintaining protein homeostasis and of myeloma cells. Increases insulin sensitivity in the liver as a response to a high carbohydrate diet, resulting in improved glucose tolerance. Also improves glucose homeostasis in an ER stress- and/or insulin-independent manner through both binding and proteasome-induced degradation of the transcription factor FOXO1, hence resulting in suppression of gluconeogenic genes expression and in a reduction of blood glucose levels. Controls the induction of de novo fatty acid synthesis in hepatocytes by regulating the expression of a subset of lipogenic genes in an ER stress- and UPR-independent manner (By similarity). Associates preferentially to the HDAC3 gene promoter region in a disturbed flow-dependent manner (PubMed:25190803). Binds to the BECN1 gene promoter region (PubMed:23184933). Binds to the CDH5/VE-cadherin gene promoter region (PubMed:19416856). Binds to the ER stress response element (ERSE) upon ER stress (PubMed:11779464). Binds to the 5'-CCACG-3' motif in the PPARG promoter (By similarity). {ECO:0000250|UniProtKB:O35426, ECO:0000269|PubMed:11779464, ECO:0000269|PubMed:15466483, ECO:0000269|PubMed:19416856, ECO:0000269|PubMed:23184933, ECO:0000269|PubMed:23529610, ECO:0000269|PubMed:25190803, ECO:0000269|PubMed:25239945, ECO:0000269|PubMed:25280941}. |
| P19484 | TFEB | S332 | ochoa | Transcription factor EB (Class E basic helix-loop-helix protein 35) (bHLHe35) | Transcription factor that acts as a master regulator of lysosomal biogenesis, autophagy, lysosomal exocytosis, lipid catabolism, energy metabolism and immune response (PubMed:21617040, PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:30120233, PubMed:31672913, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823, PubMed:36749723, PubMed:37079666). Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF (PubMed:1748288, PubMed:19556463, PubMed:29146937). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFEB phosphorylation by MTOR promotes its cytosolic retention and subsequent inactivation (PubMed:21617040, PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823). Upon starvation or lysosomal stress, inhibition of MTOR induces TFEB dephosphorylation, resulting in nuclear localization and transcription factor activity (PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823). Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression, thereby playing a central role in expression of lysosomal genes (PubMed:19556463, PubMed:22692423). Regulates lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937). Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy (PubMed:21617040, PubMed:22576015, PubMed:23434374, PubMed:27278822). In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer (PubMed:2115126). Plays a role in the signal transduction processes required for normal vascularization of the placenta (By similarity). Involved in the immune response to infection by the bacteria S.aureus, S.typhimurium or S.enterica: infection promotes itaconate production, leading to alkylation, resulting in nuclear localization and transcription factor activity (PubMed:35662396). Itaconate-mediated alkylation activates TFEB-dependent lysosomal biogenesis, facilitating the bacteria clearance during the antibacterial innate immune response (PubMed:35662396). In association with ACSS2, promotes the expression of genes involved in lysosome biogenesis and both autophagy upon glucose deprivation (PubMed:28552616). {ECO:0000250|UniProtKB:Q9R210, ECO:0000269|PubMed:1748288, ECO:0000269|PubMed:19556463, ECO:0000269|PubMed:2115126, ECO:0000269|PubMed:21617040, ECO:0000269|PubMed:22343943, ECO:0000269|PubMed:22576015, ECO:0000269|PubMed:22692423, ECO:0000269|PubMed:23434374, ECO:0000269|PubMed:25720963, ECO:0000269|PubMed:27278822, ECO:0000269|PubMed:28552616, ECO:0000269|PubMed:29146937, ECO:0000269|PubMed:30120233, ECO:0000269|PubMed:31672913, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:32753672, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:36697823, ECO:0000269|PubMed:36749723, ECO:0000269|PubMed:37079666}. |
| P23588 | EIF4B | S93 | ochoa | Eukaryotic translation initiation factor 4B (eIF-4B) | Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. |
| P26038 | MSN | S74 | ochoa | Moesin (Membrane-organizing extension spike protein) | Ezrin-radixin-moesin (ERM) family protein that connects the actin cytoskeleton to the plasma membrane and thereby regulates the structure and function of specific domains of the cell cortex. Tethers actin filaments by oscillating between a resting and an activated state providing transient interactions between moesin and the actin cytoskeleton (PubMed:10212266). Once phosphorylated on its C-terminal threonine, moesin is activated leading to interaction with F-actin and cytoskeletal rearrangement (PubMed:10212266). These rearrangements regulate many cellular processes, including cell shape determination, membrane transport, and signal transduction (PubMed:12387735, PubMed:15039356). The role of moesin is particularly important in immunity acting on both T and B-cells homeostasis and self-tolerance, regulating lymphocyte egress from lymphoid organs (PubMed:9298994, PubMed:9616160). Modulates phagolysosomal biogenesis in macrophages (By similarity). Also participates in immunologic synapse formation (PubMed:27405666). {ECO:0000250|UniProtKB:P26041, ECO:0000269|PubMed:10212266, ECO:0000269|PubMed:12387735, ECO:0000269|PubMed:15039356, ECO:0000269|PubMed:27405666, ECO:0000269|PubMed:9298994, ECO:0000269|PubMed:9616160}. |
| P28290 | ITPRID2 | S1040 | ochoa | Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) | None |
| P30281 | CCND3 | S264 | ochoa|psp | G1/S-specific cyclin-D3 | Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition (PubMed:8114739). Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase (PubMed:8114739). Hypophosphorylates RB1 in early G(1) phase (PubMed:8114739). Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals (PubMed:8114739). Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (PubMed:16782892). Shows transcriptional coactivator activity with ATF5 independently of CDK4 (PubMed:15358120). {ECO:0000269|PubMed:15358120, ECO:0000269|PubMed:16782892, ECO:0000269|PubMed:8114739}. |
| P30876 | POLR2B | S106 | ochoa | DNA-directed RNA polymerase II subunit RPB2 (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II 140 kDa polypeptide) (DNA-directed RNA polymerase II subunit B) (RNA polymerase II subunit 2) (RNA polymerase II subunit B2) (RNA-directed RNA polymerase II subunit RPB2) (EC 2.7.7.48) | Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (PubMed:27193682, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the largest subunit POLR2A/RPB1. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). {ECO:0000250|UniProtKB:A5PJW8, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:8381534, ECO:0000269|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269|PubMed:23395899}. |
| P35222 | CTNNB1 | S191 | ochoa|psp | Catenin beta-1 (Beta-catenin) | Key downstream component of the canonical Wnt signaling pathway (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). Also acts as a coactivator for other transcription factors, such as NR5A2 (PubMed:22187462). Promotes epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via driving transcription of CTNNB1/TCF-target genes (PubMed:29910125). Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (By similarity). Acts as a negative regulator of centrosome cohesion (PubMed:18086858). Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization (PubMed:21262353). Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (PubMed:18957423). Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity). Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, via promoting the transcription of differentiation factors such as LEF1, BMP2 and BMP4 (By similarity). Activity is repressed in a MSX1-mediated manner at the bell stage of mesenchymal tooth germ formation which prevents premature differentiation of odontoblasts (By similarity). {ECO:0000250|UniProtKB:Q02248, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:18077326, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18957423, ECO:0000269|PubMed:21262353, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22187462, ECO:0000269|PubMed:22647378, ECO:0000269|PubMed:22699938, ECO:0000269|PubMed:29910125}. |
| P38398 | BRCA1 | S1613 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P41231 | P2RY2 | S327 | ochoa | P2Y purinoceptor 2 (P2Y2) (ATP receptor) (P2U purinoceptor 1) (P2U1) (P2U receptor 1) (Purinergic receptor) | Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP. |
| P42229 | STAT5A | S193 | ochoa | Signal transducer and activator of transcription 5A | Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation. {ECO:0000269|PubMed:15534001}. |
| P43490 | NAMPT | S470 | ochoa | Nicotinamide phosphoribosyltransferase (NAmPRTase) (Nampt) (EC 2.4.2.12) (Pre-B-cell colony-enhancing factor 1) (Pre-B cell-enhancing factor) (Visfatin) | Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity). {ECO:0000250|UniProtKB:Q99KQ4, ECO:0000269|PubMed:24130902}. |
| P46939 | UTRN | S3297 | ochoa | Utrophin (Dystrophin-related protein 1) (DRP-1) | May play a role in anchoring the cytoskeleton to the plasma membrane. {ECO:0000250}. |
| P47900 | P2RY1 | S252 | psp | P2Y purinoceptor 1 (P2Y1) (ADP receptor) (Purinergic receptor) | Receptor for extracellular adenine nucleotides such as ADP (PubMed:25822790, PubMed:9038354, PubMed:9442040). In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately platelet aggregation (PubMed:9442040). {ECO:0000269|PubMed:25822790, ECO:0000269|PubMed:9038354, ECO:0000269|PubMed:9442040}. |
| P48634 | PRRC2A | S1004 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P49327 | FASN | S361 | ochoa | Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] | Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269|PubMed:16215233, ECO:0000269|PubMed:16969344, ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
| P49792 | RANBP2 | S1573 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P50502 | ST13 | S181 | ochoa | Hsc70-interacting protein (Hip) (Aging-associated protein 2) (Progesterone receptor-associated p48 protein) (Protein FAM10A1) (Putative tumor suppressor ST13) (Renal carcinoma antigen NY-REN-33) (Suppression of tumorigenicity 13 protein) | One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity). {ECO:0000250}. |
| P51692 | STAT5B | S193 | ochoa|psp | Signal transducer and activator of transcription 5B | Carries out a dual function: signal transduction and activation of transcription (PubMed:29844444). Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation. {ECO:0000269|PubMed:20702587, ECO:0000269|PubMed:29844444, ECO:0000269|PubMed:8732682}. |
| P51957 | NEK4 | S484 | ochoa | Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) | Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage. {ECO:0000250|UniProtKB:Q9Z1J2, ECO:0000269|PubMed:22851694}. |
| P52790 | HK3 | S67 | ochoa | Hexokinase-3 (EC 2.7.1.1) (Hexokinase type III) (HK III) (Hexokinase-C) | Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively) (PubMed:8717435). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:8717435). {ECO:0000269|PubMed:8717435}. |
| P53618 | COPB1 | S773 | ochoa | Coatomer subunit beta (Beta-coat protein) (Beta-COP) | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Plays a functional role in facilitating the transport of kappa-type opioid receptor mRNAs into axons and enhances translation of these proteins. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte surface triglyceride lipase (PNPLA2) with the lipid droplet to mediate lipolysis (By similarity). Involved in the Golgi disassembly and reassembly processes during cell cycle. Involved in autophagy by playing a role in early endosome function. Plays a role in organellar compartmentalization of secretory compartments including endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC), Golgi, trans-Golgi network (TGN) and recycling endosomes, and in biosynthetic transport of CAV1. Promotes degradation of Nef cellular targets CD4 and MHC class I antigens by facilitating their trafficking to degradative compartments. {ECO:0000250, ECO:0000269|PubMed:18385291, ECO:0000269|PubMed:18725938, ECO:0000269|PubMed:19364919, ECO:0000269|PubMed:20056612}. |
| P55197 | MLLT10 | S536 | ochoa | Protein AF-10 (ALL1-fused gene from chromosome 10 protein) | Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (PubMed:26439302). {ECO:0000269|PubMed:17868029, ECO:0000269|PubMed:26439302}. |
| P59923 | ZNF445 | S150 | ochoa | Zinc finger protein 445 (ZFP445) (Zinc finger protein 168) (Zinc finger protein with KRAB and SCAN domains 15) | Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions (ICRs) (PubMed:30602440). Acts together with ZFP57, but seems to be the major factor in human early embryonic imprinting maintenance. In contrast, in mice, ZFP57 plays the predominant role in imprinting maintenance (PubMed:30602440). {ECO:0000269|PubMed:30602440}. |
| Q00266 | MAT1A | S180 | psp | S-adenosylmethionine synthase isoform type-1 (AdoMet synthase 1) (EC 2.5.1.6) (Methionine adenosyltransferase 1) (MAT 1) (Methionine adenosyltransferase I/III) (MAT-I/III) | Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate. {ECO:0000269|PubMed:10677294}. |
| Q00610 | CLTC | S412 | ochoa | Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17) | Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872). Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilization of the lattice promoting uncoating (By similarity). {ECO:0000250|UniProtKB:P49951, ECO:0000269|PubMed:15858577, ECO:0000269|PubMed:16968737, ECO:0000269|PubMed:20639872, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}. |
| Q06418 | TYRO3 | S869 | ochoa | Tyrosine-protein kinase receptor TYRO3 (EC 2.7.10.1) (Tyrosine-protein kinase BYK) (Tyrosine-protein kinase DTK) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine-protein kinase TIF) | Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. {ECO:0000269|PubMed:20546121}.; FUNCTION: (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. {ECO:0000269|PubMed:22156524, ECO:0000269|PubMed:22673088, ECO:0000269|PubMed:25277499}.; FUNCTION: (Microbial infection) Acts as a receptor for Ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. {ECO:0000269|PubMed:17005688}. |
| Q12788 | TBL3 | S257 | ochoa | Transducin beta-like protein 3 (WD repeat-containing protein SAZD) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. {ECO:0000269|PubMed:34516797}. |
| Q13085 | ACACA | S104 | ochoa | Acetyl-CoA carboxylase 1 (ACC1) (EC 6.4.1.2) (Acetyl-Coenzyme A carboxylase alpha) (ACC-alpha) | Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis (PubMed:20457939, PubMed:20952656, PubMed:29899443). This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:20457939, PubMed:20952656, PubMed:29899443). {ECO:0000269|PubMed:20457939, ECO:0000269|PubMed:20952656, ECO:0000269|PubMed:29899443}. |
| Q13322 | GRB10 | S476 | ochoa|psp | Growth factor receptor-bound protein 10 (GRB10 adapter protein) (Insulin receptor-binding protein Grb-IR) | Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2. {ECO:0000269|PubMed:12493740, ECO:0000269|PubMed:15060076, ECO:0000269|PubMed:16434550, ECO:0000269|PubMed:17376403}. |
| Q13469 | NFATC2 | S148 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1) | Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF (PubMed:15790681). Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway (PubMed:21871017). Is involved in the negative regulation of chondrogenesis (PubMed:35789258). Recruited by AKAP5 to ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where store-operated Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses. {ECO:0000250|UniProtKB:Q60591, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:21871017, ECO:0000269|PubMed:35789258}. |
| Q13506 | NAB1 | S407 | ochoa | NGFI-A-binding protein 1 (EGR-1-binding protein 1) (Transcriptional regulatory protein p54) | Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. {ECO:0000250}. |
| Q14149 | MORC3 | S503 | ochoa | MORC family CW-type zinc finger protein 3 (Nuclear matrix protein 2) (Zinc finger CW-type coiled-coil domain protein 3) | Nuclear matrix protein which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism and plays a role in innate immunity by restricting different viruses through modulation of the IFN response (PubMed:27440897, PubMed:34759314). Mechanistically, possesses a primary antiviral function through a MORC3-regulated element that activates IFNB1, and this function is guarded by a secondary IFN-repressing function (PubMed:34759314). Sumoylated MORC3-NBs associates with PML-NBs and recruits TP53 and SP100, thus regulating TP53 activity (PubMed:17332504, PubMed:20501696). Binds RNA in vitro (PubMed:11927593). Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3 (PubMed:26933034). The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0 (PubMed:26933034). {ECO:0000269|PubMed:11927593, ECO:0000269|PubMed:17332504, ECO:0000269|PubMed:20501696, ECO:0000269|PubMed:26933034, ECO:0000269|PubMed:27440897, ECO:0000269|PubMed:34759314}.; FUNCTION: (Microbial infection) May be required for influenza A transcription during viral infection (PubMed:26202233). {ECO:0000269|PubMed:26202233}. |
| Q15013 | MAD2L1BP | S102 | ochoa|psp | MAD2L1-binding protein (Caught by MAD2 protein) (p31(comet)) | May function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex. {ECO:0000269|PubMed:18022368}. |
| Q15468 | STIL | S753 | ochoa | SCL-interrupting locus protein (TAL-1-interrupting locus protein) | Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1 (PubMed:16024801, PubMed:9372240). Plays an important role in the regulation of centriole duplication. Required for the onset of procentriole formation and proper mitotic progression. During procentriole formation, is essential for the correct loading of SASS6 and CPAP to the base of the procentriole to initiate procentriole assembly (PubMed:22020124). In complex with STIL acts as a modulator of PLK4-driven cytoskeletal rearrangements and directional cell motility (PubMed:29712910, PubMed:32107292). {ECO:0000269|PubMed:16024801, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:29712910, ECO:0000269|PubMed:32107292, ECO:0000269|PubMed:9372240}. |
| Q16584 | MAP3K11 | S524 | ochoa|psp | Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase) | Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle. {ECO:0000269|PubMed:12529434, ECO:0000269|PubMed:15258589, ECO:0000269|PubMed:8195146, ECO:0000269|PubMed:9003778}. |
| Q16647 | PTGIS | S116 | ochoa | Prostacyclin synthase (EC 5.3.99.4) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152) (Prostaglandin I2 synthase) | Catalyzes the biosynthesis and metabolism of eicosanoids. Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2), a potent mediator of vasodilation and inhibitor of platelet aggregation (PubMed:12372404, PubMed:15115769, PubMed:18032380, PubMed:25623425). Additionally, displays dehydratase activity, toward hydroperoxyeicosatetraenoates (HPETEs), especially toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) (PubMed:17459323). {ECO:0000269|PubMed:12372404, ECO:0000269|PubMed:15115769, ECO:0000269|PubMed:17459323, ECO:0000269|PubMed:18032380, ECO:0000269|PubMed:25623425}. |
| Q16762 | TST | S38 | ochoa | Thiosulfate sulfurtransferase (EC 2.8.1.1) (Rhodanese) | Formation of iron-sulfur complexes, cyanide detoxification or modification of sulfur-containing enzymes. Other thiol compounds, besides cyanide, can act as sulfur ion acceptors. Also has weak mercaptopyruvate sulfurtransferase (MST) activity (By similarity). Together with MRPL18, acts as a mitochondrial import factor for the cytosolic 5S rRNA. Only the nascent unfolded cytoplasmic form is able to bind to the 5S rRNA. {ECO:0000250, ECO:0000269|PubMed:20663881, ECO:0000269|PubMed:21685364}. |
| Q2M3V2 | SOWAHA | S252 | ochoa | Ankyrin repeat domain-containing protein SOWAHA (Ankyrin repeat domain-containing protein 43) (Protein sosondowah homolog A) | None |
| Q4KWH8 | PLCH1 | S970 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-eta-1) (Phospholipase C-eta-1) (PLC-eta-1) (Phospholipase C-like protein 3) (PLC-L3) | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by calcium-activated phosphatidylinositol-specific phospholipase C enzymes. {ECO:0000269|PubMed:15702972}. |
| Q4VC44 | FLYWCH1 | S503 | ochoa | FLYWCH-type zinc finger-containing protein 1 | Transcription cofactor (PubMed:30097457). Negatively regulates transcription activation by catenin beta-1 CTNNB1, perhaps acting by competing with TCF4 for CTNNB1 binding (PubMed:30097457). May play a role in DNA-damage response signaling (PubMed:33924684). Binds specifically to DNA sequences at peri-centromeric chromatin loci. {ECO:0000269|PubMed:30097457, ECO:0000269|PubMed:33924684, ECO:0000269|PubMed:34408139}. |
| Q53GL0 | PLEKHO1 | S342 | ochoa | Pleckstrin homology domain-containing family O member 1 (PH domain-containing family O member 1) (C-Jun-binding protein) (JBP) (Casein kinase 2-interacting protein 1) (CK2-interacting protein 1) (CKIP-1) (Osteoclast maturation-associated gene 120 protein) | Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation. {ECO:0000269|PubMed:14729969, ECO:0000269|PubMed:15706351, ECO:0000269|PubMed:15831458, ECO:0000269|PubMed:16325375, ECO:0000269|PubMed:16987810, ECO:0000269|PubMed:17197158, ECO:0000269|PubMed:17942896}. |
| Q5HYI7 | MTX3 | S249 | ochoa | Metaxin-3 | Could function in transport of proteins into the mitochondrion. {ECO:0000250}. |
| Q5JSZ5 | PRRC2B | S1843 | ochoa | Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) | None |
| Q5T5Y3 | CAMSAP1 | S1052 | ochoa | Calmodulin-regulated spectrin-associated protein 1 | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19508979, PubMed:21834987, PubMed:24117850, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and stabilizes microtubules (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation (PubMed:24486153, PubMed:24706919). Through interaction with spectrin may regulate neurite outgrowth (PubMed:24117850). {ECO:0000269|PubMed:19508979, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:24117850, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919}. |
| Q5VTB9 | RNF220 | S173 | ochoa | E3 ubiquitin-protein ligase RNF220 (EC 2.3.2.27) (RING finger protein 220) (RING-type E3 ubiquitin transferase RNF220) | E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B (By similarity). Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7-mediated deubiquitination of CTNNB1 promoting Wnt signaling (PubMed:25266658, PubMed:33964137). Plays a critical role in the regulation of nuclear lamina (PubMed:33964137). {ECO:0000250|UniProtKB:Q6PDX6, ECO:0000269|PubMed:25266658, ECO:0000269|PubMed:33964137}. |
| Q5VWQ8 | DAB2IP | S1168 | ochoa | Disabled homolog 2-interacting protein (DAB2 interaction protein) (DAB2-interacting protein) (ASK-interacting protein 1) (AIP-1) (DOC-2/DAB-2 interactive protein) | Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Involved in several processes such as innate immune response, inflammation and cell growth inhibition, apoptosis, cell survival, angiogenesis, cell migration and maturation. Also plays a role in cell cycle checkpoint control; reduces G1 phase cyclin levels resulting in G0/G1 cell cycle arrest. Mediates signal transduction by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF), interferon (IFN) or lipopolysaccharide (LPS). Modulates the balance between phosphatidylinositol 3-kinase (PI3K)-AKT-mediated cell survival and apoptosis stimulated kinase (MAP3K5)-JNK signaling pathways; sequesters both AKT1 and MAP3K5 and counterbalances the activity of each kinase by modulating their phosphorylation status in response to pro-inflammatory stimuli. Acts as a regulator of the endoplasmic reticulum (ER) unfolded protein response (UPR) pathway; specifically involved in transduction of the ER stress-response to the JNK cascade through ERN1. Mediates TNF-alpha-induced apoptosis activation by facilitating dissociation of inhibitor 14-3-3 from MAP3K5; recruits the PP2A phosphatase complex which dephosphorylates MAP3K5 on 'Ser-966', leading to the dissociation of 13-3-3 proteins and activation of the MAP3K5-JNK signaling pathway in endothelial cells. Also mediates TNF/TRAF2-induced MAP3K5-JNK activation, while it inhibits CHUK-NF-kappa-B signaling. Acts a negative regulator in the IFN-gamma-mediated JAK-STAT signaling cascade by inhibiting smooth muscle cell (VSMCs) proliferation and intimal expansion, and thus, prevents graft arteriosclerosis (GA). Acts as a GTPase-activating protein (GAP) for the ADP ribosylation factor 6 (ARF6), Ras and RAB40C (PubMed:29156729). Promotes hydrolysis of the ARF6-bound GTP and thus, negatively regulates phosphatidylinositol 4,5-bisphosphate (PIP2)-dependent TLR4-TIRAP-MyD88 and NF-kappa-B signaling pathways in endothelial cells in response to lipopolysaccharides (LPS). Binds specifically to phosphatidylinositol 4-phosphate (PtdIns4P) and phosphatidylinositol 3-phosphate (PtdIns3P). In response to vascular endothelial growth factor (VEGFA), acts as a negative regulator of the VEGFR2-PI3K-mediated angiogenic signaling pathway by inhibiting endothelial cell migration and tube formation. In the developing brain, promotes both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex in a glial-dependent locomotion process. Probable downstream effector of the Reelin signaling pathway; promotes Purkinje cell (PC) dendrites development and formation of cerebellar synapses. Also functions as a tumor suppressor protein in prostate cancer progression; prevents cell proliferation and epithelial-to-mesenchymal transition (EMT) through activation of the glycogen synthase kinase-3 beta (GSK3B)-induced beta-catenin and inhibition of PI3K-AKT and Ras-MAPK survival downstream signaling cascades, respectively. {ECO:0000269|PubMed:12813029, ECO:0000269|PubMed:17389591, ECO:0000269|PubMed:18292600, ECO:0000269|PubMed:19033661, ECO:0000269|PubMed:19903888, ECO:0000269|PubMed:19948740, ECO:0000269|PubMed:20080667, ECO:0000269|PubMed:20154697, ECO:0000269|PubMed:21700930, ECO:0000269|PubMed:22696229, ECO:0000269|PubMed:29156729}. |
| Q6NYC8 | PPP1R18 | S175 | ochoa | Phostensin (Protein phosphatase 1 F-actin cytoskeleton-targeting subunit) (Protein phosphatase 1 regulatory subunit 18) | [Isoform 1]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:24434620}.; FUNCTION: [Isoform 4]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:17374523}. |
| Q6P1L8 | MRPL14 | S49 | ochoa | Large ribosomal subunit protein uL14m (39S ribosomal protein L14, mitochondrial) (L14mt) (MRP-L14) (39S ribosomal protein L32, mitochondrial) (L32mt) (MRP-L32) | Forms part of 2 intersubunit bridges in the assembled ribosome. Upon binding to MALSU1 intersubunit bridge formation is blocked, preventing ribosome formation and repressing translation (Probable). {ECO:0000305|PubMed:22829778}. |
| Q6P2H3 | CEP85 | S270 | ochoa | Centrosomal protein of 85 kDa (Cep85) (Coiled-coil domain-containing protein 21) | Acts as a regulator of centriole duplication through a direct interaction with STIL, a key factor involved in the early steps of centriole formation. The CEP85-STIL protein complex acts as a modulator of PLK4-driven cytoskeletal rearrangements and directional cell motility (PubMed:29712910, PubMed:32107292). Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity (PubMed:26220856). {ECO:0000269|PubMed:26220856, ECO:0000269|PubMed:29712910, ECO:0000269|PubMed:32107292}. |
| Q6P4R8 | NFRKB | S228 | ochoa | Nuclear factor related to kappa-B-binding protein (DNA-binding protein R kappa-B) (INO80 complex subunit G) | Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'. {ECO:0000269|PubMed:18922472}.; FUNCTION: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex. {ECO:0000269|PubMed:18922472}. |
| Q6PGN9 | PSRC1 | S140 | ochoa | Proline/serine-rich coiled-coil protein 1 | Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression. {ECO:0000269|PubMed:18411309, ECO:0000269|PubMed:19738423, ECO:0000269|PubMed:26820536}. |
| Q6PL24 | TMED8 | S153 | ochoa | Protein TMED8 | None |
| Q6ZVH7 | ESPNL | S786 | ochoa | Espin-like protein | Binds to but does not cross-link actin. Required for the formation and maintenance of inner ear hair cell stereocilia and staircase formation. Essential for normal hearing. {ECO:0000250|UniProtKB:Q3UYR4}. |
| Q6ZW49 | PAXIP1 | S332 | ochoa | PAX-interacting protein 1 (PAX transactivation activation domain-interacting protein) | Involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. Plays a role in early development. In DNA damage response is required for cell survival after ionizing radiation. In vitro shown to be involved in the homologous recombination mechanism for the repair of double-strand breaks (DSBs). Its localization to DNA damage foci requires RNF8 and UBE2N. Recruits TP53BP1 to DNA damage foci and, at least in particular repair processes, effective DNA damage response appears to require the association with TP53BP1 phosphorylated by ATM at 'Ser-25'. Together with TP53BP1 regulates ATM association. Proposed to recruit PAGR1 to sites of DNA damage and the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage; the function is probably independent of MLL-containing histone methyltransferase (HMT) complexes. However, this function has been questioned (By similarity). Promotes ubiquitination of PCNA following UV irradiation and may regulate recruitment of polymerase eta and RAD51 to chromatin after DNA damage. Proposed to be involved in transcriptional regulation by linking MLL-containing histone methyltransferase (HMT) complexes to gene promoters by interacting with promoter-bound transcription factors such as PAX2. Associates with gene promoters that are known to be regulated by KMT2D/MLL2. During immunoglobulin class switching in activated B-cells is involved in trimethylation of histone H3 at 'Lys-4' and in transcription initiation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus; this function appears to involve the recruitment of MLL-containing HMT complexes. Conflictingly, its function in transcriptional regulation during immunoglobulin class switching is reported to be independent of the MLL2/MLL3 complex (By similarity). {ECO:0000250|UniProtKB:Q6NZQ4, ECO:0000269|PubMed:14576432, ECO:0000269|PubMed:15456759, ECO:0000269|PubMed:17690115, ECO:0000269|PubMed:17925232, ECO:0000269|PubMed:18353733, ECO:0000269|PubMed:20088963, ECO:0000269|PubMed:23727112}. |
| Q711Q0 | CEFIP | S1149 | ochoa | Cardiac-enriched FHL2-interacting protein | Plays an important role in cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. {ECO:0000250|UniProtKB:M0RD54}. |
| Q86U86 | PBRM1 | S131 | ochoa | Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation. {ECO:0000269|PubMed:21248752, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q86US8 | SMG6 | S363 | ochoa | Telomerase-binding protein EST1A (EC 3.1.-.-) (Ever shorter telomeres 1A) (hEST1A) (Nonsense mediated mRNA decay factor SMG6) (Smg-6 homolog) (hSmg5/7a) | Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini (PubMed:19179534). May have a general role in telomere regulation (PubMed:12676087, PubMed:12699629). Promotes in vitro the ability of TERT to elongate telomeres (PubMed:12676087, PubMed:12699629). Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization (PubMed:12676087, PubMed:12699629). Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER) (PubMed:12676087, PubMed:12699629). {ECO:0000269|PubMed:12676087, ECO:0000269|PubMed:12699629, ECO:0000269|PubMed:19179534}.; FUNCTION: Plays a role in nonsense-mediated mRNA decay (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). Is thought to provide a link to the mRNA degradation machinery as it has endonuclease activity required to initiate NMD, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). Degrades single-stranded RNA (ssRNA), but not ssDNA or dsRNA (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). {ECO:0000269|PubMed:17053788, ECO:0000269|PubMed:18974281, ECO:0000269|PubMed:19060897, ECO:0000269|PubMed:20930030}. |
| Q86V25 | VASH2 | S302 | ochoa | Tubulinyl-Tyr carboxypeptidase 2 (EC 3.4.17.17) (Vasohibin-2) (Vasohibin-like protein) | Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function (PubMed:29146869). Critical for spindle function and accurate chromosome segregation during mitosis since microtubule detyronisation regulates mitotic spindle length and postioning (PubMed:31171830). Acts as an activator of angiogenesis: expressed in infiltrating mononuclear cells in the sprouting front to promote angiogenesis (PubMed:19204325). Plays a role in axon formation (PubMed:31235911). {ECO:0000269|PubMed:19204325, ECO:0000269|PubMed:29146869, ECO:0000269|PubMed:31235911}. |
| Q86YT6 | MIB1 | S805 | ochoa | E3 ubiquitin-protein ligase MIB1 (EC 2.3.2.27) (DAPK-interacting protein 1) (DIP-1) (Mind bomb homolog 1) (RING-type E3 ubiquitin transferase MIB1) (Zinc finger ZZ type with ankyrin repeat domain protein 2) | E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation. {ECO:0000250, ECO:0000269|PubMed:24121310}.; FUNCTION: (Microbial infection) During adenovirus infection, mediates ubiquitination of Core-capsid bridging protein. This allows viral genome delivery into nucleus for infection. {ECO:0000269|PubMed:31851912}. |
| Q8IUG5 | MYO18B | S2309 | ochoa | Unconventional myosin-XVIIIb | May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth. |
| Q8IWT3 | CUL9 | S2436 | ochoa | Cullin-9 (CUL-9) (UbcH7-associated protein 1) (p53-associated parkin-like cytoplasmic protein) | Core component of a Cul9-RING ubiquitin-protein ligase complex composed of CUL9 and RBX1 (PubMed:38605244). The CUL9-RBX1 complex mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity. Acts downstream of the 3M complex, which inhibits the ubiquitination of BIRC5 (PubMed:24793696). The CUL9-RBX1 complex also mediates mono-ubiquitination of p53/TP53 (PubMed:38605244). Acts as a cytoplasmic anchor protein in p53/TP53-associated protein complex. Regulates the subcellular localization of p53/TP53 and its subsequent function (PubMed:12526791, PubMed:17332328). Ubiquitinates apurinic/apyrimidinic endodeoxyribonuclease APEX2 (PubMed:38605244). Ubiquitination by the CUL9-RBX1 complex is predominantly mediated by E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2D2 (PubMed:38605244). {ECO:0000269|PubMed:12526791, ECO:0000269|PubMed:17332328, ECO:0000269|PubMed:24793696, ECO:0000269|PubMed:38605244}. |
| Q8IZP2 | ST13P4 | S177 | ochoa | Putative protein FAM10A4 (Suppression of tumorigenicity 13 pseudogene 4) | None |
| Q8N4C6 | NIN | S1970 | ochoa | Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein) | Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells (PubMed:15190203, PubMed:23386061). May also act as a centrosome maturation factor (PubMed:11956314). May play a role in microtubule nucleation, by recruiting the gamma-tubulin ring complex to the centrosome (PubMed:15190203). Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules (PubMed:15190203). Required for centriole organization and microtubule anchoring at the mother centriole (PubMed:23386061). {ECO:0000269|PubMed:11956314, ECO:0000269|PubMed:15190203, ECO:0000269|PubMed:23386061}. |
| Q8N7R7 | CCNYL1 | S112 | ochoa | Cyclin-Y-like protein 1 | Key regulator of Wnt signaling implicated in various biological processes including male fertility, embryonic neurogenesis and cortex development. Activates the cyclin-dependent kinase CDK16, and promotes sperm maturation. {ECO:0000250|UniProtKB:D3YUJ3}. |
| Q8N9N5 | BANP | S90 | ochoa | Protein BANP (BEN domain-containing protein 1) (Btg3-associated nuclear protein) (Scaffold/matrix-associated region-1-binding protein) | Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function (By similarity). Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer (By similarity). Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels (PubMed:16166625). Promotes TP53 activation, which causes cell cycle arrest (By similarity). Plays a role in the regulation of alternative splicing (PubMed:26080397). Binds to CD44 pre-mRNA and negatively regulates the inclusion of CD44 proximal variable exons v2-v6 but has no effect on distal variable exons v7-v10 (PubMed:26080397). {ECO:0000250|UniProtKB:Q8VBU8, ECO:0000269|PubMed:16166625, ECO:0000269|PubMed:26080397}. |
| Q8NDT2 | RBM15B | S609 | ochoa | Putative RNA-binding protein 15B (One-twenty two protein 3) (HsOTT3) (HuOTT3) (RNA-binding motif protein 15B) | RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:16129689, PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:27602518). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Functions in the regulation of alternative or illicit splicing, possibly by regulating m6A methylation (PubMed:16129689). Inhibits pre-mRNA splicing (PubMed:21044963). Also functions as a mRNA export factor by acting as a cofactor for the nuclear export receptor NXF1 (PubMed:19586903). {ECO:0000269|PubMed:19586903, ECO:0000269|PubMed:21044963, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:16129689}. |
| Q8NFU7 | TET1 | S322 | ochoa | Methylcytosine dioxygenase TET1 (EC 1.14.11.80) (CXXC-type zinc finger protein 6) (Leukemia-associated protein with a CXXC domain) (Ten-eleven translocation 1 gene protein) | Dioxygenase that plays a key role in active DNA demethylation, by catalyzing the sequential oxidation of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) (PubMed:19372391, PubMed:21496894, PubMed:21778364, PubMed:35798741). In addition to its role in DNA demethylation, plays a more general role in chromatin regulation by recruiting histone modifying protein complexes to alter histone marks and chromatin accessibility, leading to both activation and repression of gene expression (PubMed:33833093). Plays therefore a role in many biological processes, including stem cell maintenance, T- and B-cell development, inflammation regulation, genomic imprinting, neural activity or DNA repair (PubMed:31278917). Involved in the balance between pluripotency and lineage commitment of cells and plays a role in embryonic stem cells maintenance and inner cell mass cell specification. Together with QSER1, plays an essential role in the protection and maintenance of transcriptional and developmental programs to inhibit the binding of DNMT3A/3B and therefore de novo methylation (PubMed:33833093). May play a role in pancreatic beta-cell specification during development. In this context, may function as an upstream epigenetic regulator of PAX4 presumably through direct recruitment by FOXA2 to a PAX4 enhancer to preserve its unmethylated status, thereby potentiating PAX4 expression to adopt beta-cell fate during endocrine lineage commitment (PubMed:35798741). Under DNA hypomethylation conditions, such as in female meiotic germ cells, may induce epigenetic reprogramming of pericentromeric heterochromatin (PCH), the constitutive heterochromatin of pericentromeric regions. PCH forms chromocenters in the interphase nucleus and chromocenters cluster at the prophase of meiosis. In this context, may also be essential for chromocenter clustering in a catalytic activity-independent manner, possibly through the recruitment polycomb repressive complex 1 (PRC1) to the chromocenters (By similarity). During embryonic development, may be required for normal meiotic progression in oocytes and meiotic gene activation (By similarity). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (PubMed:29276034). {ECO:0000250|UniProtKB:Q3URK3, ECO:0000269|PubMed:12124344, ECO:0000269|PubMed:19372391, ECO:0000269|PubMed:19372393, ECO:0000269|PubMed:21496894, ECO:0000269|PubMed:21778364, ECO:0000269|PubMed:25284789, ECO:0000269|PubMed:29276034, ECO:0000269|PubMed:31278917, ECO:0000269|PubMed:33833093, ECO:0000269|PubMed:35798741}.; FUNCTION: [Isoform 1]: Dioxygenase that plays a key role in active DNA demethylation (PubMed:28531272). Binds to promoters, particularly to those with high CG content (By similarity). In hippocampal neurons, isoform 1 regulates the expression of a unique subset of genes compared to isoform 2, although some overlap exists between both isoforms, hence differentially regulates excitatory synaptic transmission (By similarity). In hippocampal neuron cell cultures, isoform 1 controls both miniature excitatory postsynaptic current amplitude and frequency (By similarity). Isoform 1 may regulate genes involved in hippocampal-dependent memory, leading to positive regulation of memory, contrary to isoform 2 that may decrease memory (By similarity). {ECO:0000250|UniProtKB:Q3URK3, ECO:0000269|PubMed:28531272}.; FUNCTION: [Isoform 2]: Dioxygenase that plays a key role in active DNA demethylation (PubMed:28531272). As isoform 1, binds to promoters, particularly to those with high CG content, however displays reduced global chromatin affinity compared with isoform 1, leading to decreased global DNA demethylation compared with isoform 1 (By similarity). Contrary to isoform 1, isoform 2 localizes during S phase to sites of ongoing DNA replication in heterochromatin, causing a significant de novo 5hmC formation, globally, and more so in heterochromatin, including LINE 1 interspersed DNA repeats leading to their activation (By similarity). In hippocampal neurons, isoform 2 regulates the expression of a unique subset of genes compared to isoform 1, although some overlap between both isoforms, hence differentially regulates excitatory synaptic transmission (By similarity). In hippocampal neuron cell cultures, isoform 2 controls miniature excitatory postsynaptic current frequency, but not amplitude (By similarity). Isoform 2 may regulate genes involved in hippocampal-dependent memory, leading to negative regulation of memory, contrary to isoform 1 that may improve memory (By similarity). In immature and partially differentiated gonadotrope cells, directly represses luteinizing hormone gene LHB expression and does not catalyze 5hmC at the gene promoter (By similarity). {ECO:0000250|UniProtKB:Q3URK3, ECO:0000269|PubMed:28531272}. |
| Q8TBM8 | DNAJB14 | S60 | ochoa | DnaJ homolog subfamily B member 14 | Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway (PubMed:24732912). Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities (PubMed:24732912). Can also act independently of HSPA8/Hsc70: together with DNAJB12, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers (PubMed:27916661). While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70 (PubMed:27916661). When overexpressed, forms membranous structures together with DNAJB12 and HSPA8/Hsc70 within the nucleus; the role of these structures, named DJANGOs, is still unclear (PubMed:24732912). {ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27916661}.; FUNCTION: (Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection (PubMed:21673190, PubMed:24675744). {ECO:0000269|PubMed:21673190, ECO:0000269|PubMed:24675744}. |
| Q8TCS8 | PNPT1 | S754 | ochoa | Polyribonucleotide nucleotidyltransferase 1, mitochondrial (EC 2.7.7.8) (3'-5' RNA exonuclease OLD35) (PNPase old-35) (Polynucleotide phosphorylase 1) (PNPase 1) (Polynucleotide phosphorylase-like protein) | RNA-binding protein implicated in numerous RNA metabolic processes (PubMed:29967381, PubMed:39019044). Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'-to-5' direction (PubMed:29967381, PubMed:39019044). Mitochondrial intermembrane factor with RNA-processing exoribonulease activity (PubMed:29967381, PubMed:39019044). Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner (PubMed:29967381, PubMed:39019044). Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules (PubMed:29967381, PubMed:39019044). Required for correct processing and polyadenylation of mitochondrial mRNAs. Plays a role as a cytoplasmic RNA import factor that mediates the translocation of small RNA components, like the 5S RNA, the RNA subunit of ribonuclease P and the mitochondrial RNA-processing (MRP) RNA, into the mitochondrial matrix. Plays a role in mitochondrial morphogenesis and respiration; regulates the expression of the electron transport chain (ETC) components at the mRNA and protein levels. In the cytoplasm, shows a 3'-to-5' exoribonuclease mediating mRNA degradation activity; degrades c-myc mRNA upon treatment with IFNB1/IFN-beta, resulting in a growth arrest in melanoma cells. Regulates the stability of specific mature miRNAs in melanoma cells; specifically and selectively degrades miR-221, preferentially. Also plays a role in RNA cell surveillance by cleaning up oxidized RNAs. Binds to the RNA subunit of ribonuclease P, MRP RNA and miR-221 microRNA. {ECO:0000269|PubMed:12473748, ECO:0000269|PubMed:12721301, ECO:0000269|PubMed:12798676, ECO:0000269|PubMed:16055741, ECO:0000269|PubMed:16410805, ECO:0000269|PubMed:16934922, ECO:0000269|PubMed:18083836, ECO:0000269|PubMed:18083837, ECO:0000269|PubMed:18501193, ECO:0000269|PubMed:19509288, ECO:0000269|PubMed:20547861, ECO:0000269|PubMed:20691904, ECO:0000269|PubMed:29967381, ECO:0000269|PubMed:39019044}. |
| Q8TDF6 | RASGRP4 | S184 | ochoa | RAS guanyl-releasing protein 4 | Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP (PubMed:11880369, PubMed:11956218, PubMed:12493770, PubMed:18024961). In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting Ras-mediated activation of PIK3CG/PI3Kgamma to promote neutrophil functional responses (By similarity). In CD117(+) dendritic cells and mast cells, participates in an lipopolysaccharide (LPS)-activated signaling pathway that stimulates the production of interferon-gamma and other pro-inflammatory cytokines by natural killer (NK) cells (By similarity). May function in mast cell differentiation (PubMed:11880369, PubMed:11956218, PubMed:12493770, PubMed:18024961). Does not appear to be required for the development of B-cells, DC-cells, T-cells, or NK-cells (By similarity). {ECO:0000250|UniProtKB:Q8BTM9, ECO:0000269|PubMed:11880369, ECO:0000269|PubMed:11956218, ECO:0000269|PubMed:12493770, ECO:0000269|PubMed:18024961}. |
| Q8TDQ1 | CD300LF | S216 | psp | CMRF35-like molecule 1 (CLM-1) (CD300 antigen-like family member F) (Immune receptor expressed on myeloid cells 1) (IREM-1) (Immunoglobulin superfamily member 13) (IgSF13) (NK inhibitory receptor) (CD antigen CD300f) | Acts as an inhibitory receptor for myeloid cells and mast cells (PubMed:15549731). Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis (By similarity). Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide and sphingomyelin which act as ligands (PubMed:24035150). May act as a coreceptor for interleukin 4 (IL-4). Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling (By similarity). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:22043923). Inhibits osteoclast formation. Induces macrophage cell death upon engagement (By similarity). {ECO:0000250|UniProtKB:Q6SJQ7, ECO:0000269|PubMed:15549731, ECO:0000269|PubMed:22043923, ECO:0000269|PubMed:24035150}. |
| Q8TF40 | FNIP1 | S272 | ochoa | Folliculin-interacting protein 1 | Binding partner of the GTPase-activating protein FLCN: involved in the cellular response to amino acid availability by regulating the non-canonical mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3 (PubMed:17028174, PubMed:18663353, PubMed:24081491, PubMed:37079666). Required to promote FLCN recruitment to lysosomes and interaction with Rag GTPases, leading to activation of the non-canonical mTORC1 signaling (PubMed:24081491). In low-amino acid conditions, component of the lysosomal folliculin complex (LFC) on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, thereby inactivating mTORC1 and promoting nuclear translocation of TFEB and TFE3 (By similarity). Upon amino acid restimulation, disassembly of the LFC complex liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent inactivation of TFEB and TFE3 (PubMed:37079666). Together with FLCN, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy (PubMed:25126726). In addition to its role in mTORC1 signaling, also acts as a co-chaperone of HSP90AA1/Hsp90: following gradual phosphorylation by CK2, inhibits the ATPase activity of HSP90AA1/Hsp90, leading to activate both kinase and non-kinase client proteins of HSP90AA1/Hsp90 (PubMed:27353360, PubMed:30699359). Acts as a scaffold to load client protein FLCN onto HSP90AA1/Hsp90 (PubMed:27353360). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360). Also acts as a core component of the reductive stress response by inhibiting activation of mitochondria in normal conditions: in response to reductive stress, the conserved Cys degron is reduced, leading to recognition and polyubiquitylation by the CRL2(FEM1B) complex, followed by proteasomal (By similarity). Required for B-cell development (PubMed:32905580). {ECO:0000250|UniProtKB:Q68FD7, ECO:0000250|UniProtKB:Q9P278, ECO:0000269|PubMed:17028174, ECO:0000269|PubMed:18663353, ECO:0000269|PubMed:24081491, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:30699359, ECO:0000269|PubMed:32905580, ECO:0000269|PubMed:37079666}. |
| Q8WUF5 | PPP1R13L | S316 | ochoa | RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (NFkB-interacting protein 1) (PPP1R13B-like protein) | Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (PubMed:12524540). Is involved in NF-kappa-B dependent negative regulation of inflammatory response (PubMed:28069640). {ECO:0000269|PubMed:10336463, ECO:0000269|PubMed:12134007, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:15489900, ECO:0000269|PubMed:28069640}. |
| Q8WY36 | BBX | S75 | ochoa | HMG box transcription factor BBX (Bobby sox homolog) (HMG box-containing protein 2) | Transcription factor that is necessary for cell cycle progression from G1 to S phase. {ECO:0000269|PubMed:11680820}. |
| Q8WYP5 | AHCTF1 | S2120 | ochoa | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}. |
| Q92667 | AKAP1 | S169 | ochoa | A-kinase anchor protein 1, mitochondrial (A-kinase anchor protein 149 kDa) (AKAP 149) (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Protein kinase A-anchoring protein 1) (PRKA1) (Spermatid A-kinase anchor protein 84) (S-AKAP84) | Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane (By similarity). Involved in mitochondrial-mediated antiviral innate immunity (PubMed:31522117). Promotes translocation of NDUFS1 into mitochondria to regulate mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) activity (By similarity). {ECO:0000250|UniProtKB:O08715, ECO:0000269|PubMed:31522117}. |
| Q92733 | PRCC | S212 | ochoa | Proline-rich protein PRCC (Papillary renal cell carcinoma translocation-associated gene protein) | May regulate cell cycle progression through interaction with MAD2L2. {ECO:0000269|PubMed:11717438}. |
| Q92826 | HOXB13 | S31 | psp | Homeobox protein Hox-B13 | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds preferentially to methylated DNA (PubMed:28473536). {ECO:0000269|PubMed:28473536}. |
| Q96CC6 | RHBDF1 | S61 | ochoa | Inactive rhomboid protein 1 (iRhom1) (Epidermal growth factor receptor-related protein) (Rhomboid 5 homolog 1) (Rhomboid family member 1) (p100hRho) | Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. {ECO:0000269|PubMed:15965977, ECO:0000269|PubMed:18524845, ECO:0000269|PubMed:18832597, ECO:0000269|PubMed:21439629}. |
| Q96E22 | NUS1 | S168 | ochoa | Dehydrodolichyl diphosphate synthase complex subunit NUS1 (EC 2.5.1.87) (Cis-prenyltransferase subunit NgBR) (Nogo-B receptor) (NgBR) (Nuclear undecaprenyl pyrophosphate synthase 1 homolog) | With DHDDS, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery (PubMed:21572394, PubMed:25066056, PubMed:28842490, PubMed:32817466, PubMed:33077723). Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER) (PubMed:21572394, PubMed:25066056, PubMed:28842490, PubMed:32817466, PubMed:33077723). Synthesizes long-chain polyprenols, mostly of C95 and C100 chain length (PubMed:32817466). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol (PubMed:21572394). Acts as a specific receptor for the N-terminus of Nogo-B, a neural and cardiovascular regulator (PubMed:16835300). {ECO:0000269|PubMed:16835300, ECO:0000269|PubMed:21572394, ECO:0000269|PubMed:25066056, ECO:0000269|PubMed:28842490, ECO:0000269|PubMed:32817466, ECO:0000269|PubMed:33077723}. |
| Q96HA9 | PEX11G | S164 | ochoa | Peroxisomal membrane protein 11C (Peroxin-11C) (Peroxisomal biogenesis factor 11C) (Protein PEX11 homolog gamma) (PEX11-gamma) | Promotes membrane protrusion and elongation on the peroxisomal surface. {ECO:0000269|PubMed:20826455}. |
| Q96HW7 | INTS4 | S600 | ochoa | Integrator complex subunit 4 (Int4) | Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:29471365, PubMed:33243860, PubMed:33548203, PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:33243860, PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144). Within the integrator complex, INTS4 acts as an scaffold that links INTS9 and INTS11 (PubMed:29471365, PubMed:33548203). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267). {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:29471365, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:33548203, ECO:0000269|PubMed:38570683}. |
| Q96L73 | NSD1 | S2623 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) | Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context. {ECO:0000269|PubMed:21196496}. |
| Q96N21 | TEPSIN | S333 | ochoa | AP-4 complex accessory subunit Tepsin (ENTH domain-containing protein 2) (Epsin for AP-4) (Tetra-epsin) | Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network. {ECO:0000305|PubMed:22472443, ECO:0000305|PubMed:26542808}. |
| Q96NM4 | TOX2 | S351 | ochoa | TOX high mobility group box family member 2 (Granulosa cell HMG box protein 1) (GCX-1) | Putative transcriptional activator involved in the hypothalamo-pituitary-gonadal system. |
| Q96P50 | ACAP3 | S544 | ochoa | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 (Centaurin-beta-5) (Cnt-b5) | GTPase-activating protein for the ADP ribosylation factor family. {ECO:0000305}. |
| Q96PE3 | INPP4A | S487 | ochoa | Inositol polyphosphate-4-phosphatase type I A (Inositol polyphosphate 4-phosphatase type I) (Type I inositol 3,4-bisphosphate 4-phosphatase) (EC 3.1.3.66) | Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) (PubMed:15716355, PubMed:20463662). Also catalyzes inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate (By similarity). Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (By similarity) (PubMed:30071275). May protect neurons from excitotoxic cell death by regulating the synaptic localization of cell surface N-methyl-D-aspartate-type glutamate receptors (NMDARs) and NMDAR-mediated excitatory postsynaptic current (By similarity). {ECO:0000250|UniProtKB:Q62784, ECO:0000250|UniProtKB:Q9EPW0, ECO:0000269|PubMed:15716355, ECO:0000269|PubMed:20463662, ECO:0000269|PubMed:30071275}.; FUNCTION: [Isoform 4]: Displays no 4-phosphatase activity for PtdIns(3,4)P2, Ins(3,4)P2, or Ins(1,3,4)P3. {ECO:0000269|PubMed:9295334}. |
| Q96QT6 | PHF12 | S769 | ochoa | PHD finger protein 12 (PHD factor 1) (Pf1) | Transcriptional repressor acting as key scaffolding subunit of SIN3 complexes which contributes to complex assembly by contacting each core subunit domain, stabilizes the complex and constitutes the substrate receptor by recruiting the H3 histone tail (PubMed:37137925). SIN3 complexes are composed of a SIN3 scaffold subunit, one catalytic core (HDAC1 or HDAC2) and 2 chromatin targeting modules (PubMed:11390640, PubMed:37137925). SIN3B complex represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2 (PubMed:37137925). SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription (PubMed:21041482). May also repress transcription in a SIN3A-independent manner through recruitment of functional TLE5 complexes to DNA (PubMed:11390640). May also play a role in ribosomal biogenesis (By similarity). {ECO:0000250|UniProtKB:Q5SPL2, ECO:0000269|PubMed:11390640, ECO:0000269|PubMed:21041482, ECO:0000269|PubMed:37137925}. |
| Q96S19 | METTL26 | S149 | ochoa | Methyltransferase-like 26 | None |
| Q9BSJ8 | ESYT1 | S324 | ochoa | Extended synaptotagmin-1 (E-Syt1) (Membrane-bound C2 domain-containing protein) | Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels (PubMed:23791178, PubMed:24183667). Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane (PubMed:24183667). Acts as an inhibitor of ADGRD1 G-protein-coupled receptor activity in absence of cytosolic calcium (PubMed:38758649). Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). {ECO:0000250|UniProtKB:A0FGR8, ECO:0000269|PubMed:23791178, ECO:0000269|PubMed:24183667, ECO:0000269|PubMed:38758649}. |
| Q9BVN2 | RUSC1 | S831 | ochoa | AP-4 complex accessory subunit RUSC1 (New molecule containing SH3 at the carboxy-terminus) (Nesca) (RUN and SH3 domain-containing protein 1) | Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network (PubMed:30262884). Signaling adapter which plays a role in neuronal differentiation (PubMed:15024033). Involved in regulation of NGF-dependent neurite outgrowth (PubMed:15024033). May play a role in neuronal vesicular trafficking, specifically involving pre-synaptic membrane proteins (By similarity). Seems to be involved in signaling pathways that are regulated by the prolonged activation of MAPK (PubMed:15024033). Can regulate the polyubiquitination of IKBKG and thus may be involved in regulation of the NF-kappa-B pathway (PubMed:19365808). {ECO:0000250|UniProtKB:Q8BG26, ECO:0000269|PubMed:15024033, ECO:0000269|PubMed:19365808, ECO:0000269|PubMed:30262884}. |
| Q9BWN1 | PRR14 | S42 | ochoa | Proline-rich protein 14 | Functions in tethering peripheral heterochromatin to the nuclear lamina during interphase, possibly through the interaction with heterochromatin protein CBX5/HP1 alpha (PubMed:24209742). Might play a role in reattaching heterochromatin to the nuclear lamina at mitotic exit (PubMed:24209742). Promotes myoblast differentiation during skeletal myogenesis, possibly by stimulating transcription factor MyoD activity via binding to CBX5/HP1 alpha (PubMed:25906157). Involved in the positive regulation of the PI3K-Akt-mTOR signaling pathway and in promoting cell proliferation, possibly via binding to GRB2 (PubMed:27041574). {ECO:0000269|PubMed:24209742, ECO:0000269|PubMed:25906157, ECO:0000269|PubMed:27041574}. |
| Q9BZR8 | BCL2L14 | S44 | ochoa | Apoptosis facilitator Bcl-2-like protein 14 (Bcl2-L-14) (Apoptosis regulator Bcl-G) | Plays a role in apoptosis. |
| Q9C0C2 | TNKS1BP1 | S601 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9H0K1 | SIK2 | S379 | ochoa | Serine/threonine-protein kinase SIK2 (EC 2.7.11.1) (Qin-induced kinase) (Salt-inducible kinase 2) (SIK-2) (Serine/threonine-protein kinase SNF1-like kinase 2) | Serine/threonine-protein kinase that plays a role in many biological processes such as fatty acid oxidation, autophagy, immune response or glucose metabolism (PubMed:23322770, PubMed:26983400). Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators (PubMed:15454081). Phosphorylates EP300 and thus inhibits its histone acetyltransferase activity (PubMed:21084751, PubMed:26983400). In turn, regulates the DNA-binding ability of several transcription factors such as PPARA or MLXIPL (PubMed:21084751, PubMed:26983400). Also plays a role in thymic T-cell development (By similarity). {ECO:0000250|UniProtKB:Q8CFH6, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:21084751, ECO:0000269|PubMed:23322770, ECO:0000269|PubMed:26983400}. |
| Q9H6A9 | PCNX3 | S402 | ochoa | Pecanex-like protein 3 (Pecanex homolog protein 3) | None |
| Q9H6U6 | BCAS3 | S161 | ochoa | BCAS3 microtubule associated cell migration factor (Breast carcinoma-amplified sequence 3) (GAOB1) | Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation (By similarity). Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin. Plays a regulatory role in autophagic activity. In complex with PHAF1, associates with the preautophagosomal structure during both non-selective and selective autophagy (PubMed:33499712). Probably binds phosphatidylinositol 3-phosphate (PtdIns3P) which would mediate the recruitment preautophagosomal structures (PubMed:33499712). {ECO:0000250|UniProtKB:Q8CCN5, ECO:0000269|PubMed:17505058, ECO:0000269|PubMed:33499712}. |
| Q9HCK8 | CHD8 | S2211 | ochoa | Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.-) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1) | ATP-dependent chromatin-remodeling factor, it slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. Regulates alternative splicing of a core group of genes involved in neuronal differentiation, cell cycle and DNA repair. Enables H3K36me3-coupled transcription elongation and co-transcriptional RNA processing likely via interaction with HNRNPL. {ECO:0000255|HAMAP-Rule:MF_03071, ECO:0000269|PubMed:17938208, ECO:0000269|PubMed:18378692, ECO:0000269|PubMed:28533432, ECO:0000269|PubMed:36537238}. |
| Q9NPC7 | MYNN | S282 | ochoa | Myoneurin (Zinc finger and BTB domain-containing protein 31) | None |
| Q9NRA8 | EIF4ENIF1 | S301 | ochoa|psp | Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) | EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}. |
| Q9NRA8 | EIF4ENIF1 | S611 | ochoa | Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) | EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}. |
| Q9NRL2 | BAZ1A | S1371 | ochoa | Bromodomain adjacent to zinc finger domain protein 1A (ATP-dependent chromatin-remodeling protein) (ATP-utilizing chromatin assembly and remodeling factor 1) (hACF1) (CHRAC subunit ACF1) (Williams syndrome transcription factor-related chromatin-remodeling factor 180) (WCRF180) (hWALp1) | Regulatory subunit of the ATP-dependent ACF-1 and ACF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and slide edge- and center-positioned histone octamers away from their original location on the DNA template to facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:17099699, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:14759371, PubMed:17099699, PubMed:28801535). The ACF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the ACF-5 ISWI chromatin remodeling complex (PubMed:28801535). Has a role in sensing the length of DNA which flank nucleosomes, which modulates the nucleosome spacing activity of the ACF-5 ISWI chromatin remodeling complex (PubMed:17099699). Involved in DNA replication and together with SMARCA5/SNF2H is required for replication of pericentric heterochromatin in S-phase (PubMed:12434153). May have a role in nuclear receptor-mediated transcription repression (PubMed:17519354). {ECO:0000269|PubMed:12434153, ECO:0000269|PubMed:14759371, ECO:0000269|PubMed:17099699, ECO:0000269|PubMed:17519354, ECO:0000269|PubMed:28801535}. |
| Q9NRL2 | BAZ1A | S1417 | ochoa | Bromodomain adjacent to zinc finger domain protein 1A (ATP-dependent chromatin-remodeling protein) (ATP-utilizing chromatin assembly and remodeling factor 1) (hACF1) (CHRAC subunit ACF1) (Williams syndrome transcription factor-related chromatin-remodeling factor 180) (WCRF180) (hWALp1) | Regulatory subunit of the ATP-dependent ACF-1 and ACF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and slide edge- and center-positioned histone octamers away from their original location on the DNA template to facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:17099699, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:14759371, PubMed:17099699, PubMed:28801535). The ACF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the ACF-5 ISWI chromatin remodeling complex (PubMed:28801535). Has a role in sensing the length of DNA which flank nucleosomes, which modulates the nucleosome spacing activity of the ACF-5 ISWI chromatin remodeling complex (PubMed:17099699). Involved in DNA replication and together with SMARCA5/SNF2H is required for replication of pericentric heterochromatin in S-phase (PubMed:12434153). May have a role in nuclear receptor-mediated transcription repression (PubMed:17519354). {ECO:0000269|PubMed:12434153, ECO:0000269|PubMed:14759371, ECO:0000269|PubMed:17099699, ECO:0000269|PubMed:17519354, ECO:0000269|PubMed:28801535}. |
| Q9NRL3 | STRN4 | S342 | ochoa | Striatin-4 (Zinedin) | Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753, PubMed:32640226). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling (PubMed:32640226). Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). Key regulator of the expanded Hippo signaling pathway by interacting and allowing the inhibition of MAP4K kinases by the STRIPAK complex (PubMed:32640226). {ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:32640226, ECO:0000305|PubMed:26876214}. |
| Q9NRS6 | SNX15 | S180 | ochoa | Sorting nexin-15 | May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN. {ECO:0000269|PubMed:11085978}. |
| Q9NRW4 | DUSP22 | S58 | ochoa | Dual specificity protein phosphatase 22 (EC 3.1.3.16) (EC 3.1.3.48) (JNK pathway associated phosphatase) (JKAP) (JNK-stimulatory phosphatase-1) (JSP-1) (Low molecular weight dual specificity phosphatase 2) (LMW-DSP2) (Mitogen-activated protein kinase phosphatase x) (MAP kinase phosphatase x) (MKP-x) | Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues (PubMed:24714587, PubMed:38225265). Activates the JNK signaling pathway (PubMed:11717427). Inhibits T-cell receptor signaling and T-cell mediated immune responses, acting, at least in part, by inducing degradation of E3 ubiquitin ligase UBR2 (PubMed:24714587, PubMed:38225265). Dephosphorylates and thereby induces 'Lys-48'-linked ubiquitination of UBR2, leading to proteasomal degradation of UBR2 (PubMed:38225265). Dephosphorylates and thereby inactivates tyrosine kinase LCK (PubMed:24714587). Inhibits UBR2-mediated 'Lys-63'-linked ubiquitination of LCK (PubMed:38225265). May play a role in B-cell receptor (BCR) signaling and B-cell function (By similarity). {ECO:0000250|UniProtKB:Q99N11, ECO:0000269|PubMed:11717427, ECO:0000269|PubMed:24714587, ECO:0000269|PubMed:38225265}. |
| Q9NSI6 | BRWD1 | S701 | ochoa | Bromodomain and WD repeat-containing protein 1 (WD repeat-containing protein 9) | May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000250, ECO:0000269|PubMed:21834987}. |
| Q9NUQ9 | CYRIB | S117 | ochoa | CYFIP-related Rac1 interactor B (L1) | Negatively regulates RAC1 signaling and RAC1-driven cytoskeletal remodeling (PubMed:30250061, PubMed:31285585). Regulates chemotaxis, cell migration and epithelial polarization by controlling the polarity, plasticity, duration and extent of protrusions. Limits Rac1 mediated activation of the Scar/WAVE complex, focuses protrusion signals and regulates pseudopod complexity by inhibiting Scar/WAVE-induced actin polymerization (PubMed:30250061). Protects against Salmonella bacterial infection. Attenuates processes such as macropinocytosis, phagocytosis and cell migration and restrict sopE-mediated bacterial entry (PubMed:31285585). Also restricts infection mediated by Mycobacterium tuberculosis and Listeria monocytogenes (By similarity). Involved in the regulation of mitochondrial dynamics and oxidative stress (PubMed:29059164). {ECO:0000250|UniProtKB:Q921M7, ECO:0000269|PubMed:29059164, ECO:0000269|PubMed:30250061, ECO:0000269|PubMed:31285585}. |
| Q9NYL9 | TMOD3 | S59 | ochoa | Tropomodulin-3 (Ubiquitous tropomodulin) (U-Tmod) | Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity). {ECO:0000250}. |
| Q9NZQ9 | TMOD4 | S58 | ochoa | Tropomodulin-4 (Skeletal muscle tropomodulin) (Sk-Tmod) | Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. |
| Q9NZT2 | OGFR | S378 | ochoa | Opioid growth factor receptor (OGFr) (Protein 7-60) (Zeta-type opioid receptor) | Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation. |
| Q9P2B7 | CFAP97 | S474 | ochoa | Cilia- and flagella-associated protein 97 | None |
| Q9P2F6 | ARHGAP20 | S1113 | ochoa | Rho GTPase-activating protein 20 (Rho-type GTPase-activating protein 20) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| Q9P2F8 | SIPA1L2 | S1461 | ochoa | Signal-induced proliferation-associated 1-like protein 2 (SIPA1-like protein 2) | None |
| Q9UIJ5 | ZDHHC2 | S248 | ochoa | Palmitoyltransferase ZDHHC2 (EC 2.3.1.225) (Acyltransferase ZDHHC2) (EC 2.3.1.-) (Reduced expression associated with metastasis protein) (Ream) (Reduced expression in cancer protein) (Rec) (Zinc finger DHHC domain-containing protein 2) (DHHC-2) (Zinc finger protein 372) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes (PubMed:18296695, PubMed:18508921, PubMed:19144824, PubMed:21343290, PubMed:22034844, PubMed:23793055). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). In the nervous system, plays a role in long term synaptic potentiation by palmitoylating AKAP5 through which it regulates protein trafficking from the dendritic recycling endosomes to the plasma membrane and controls both structural and functional plasticity at excitatory synapses (By similarity). In dendrites, mediates the palmitoylation of DLG4 when synaptic activity decreases and induces synaptic clustering of DLG4 and associated AMPA-type glutamate receptors (By similarity). Also mediates the de novo and turnover palmitoylation of RGS7BP, a shuttle for Gi/o-specific GTPase-activating proteins/GAPs, promoting its localization to the plasma membrane in response to the activation of G protein-coupled receptors. Through the localization of these GTPase-activating proteins/GAPs, it also probably plays a role in G protein-coupled receptors signaling in neurons (By similarity). Also probably plays a role in cell adhesion by palmitoylating CD9 and CD151 to regulate their expression and function (PubMed:18508921). Palmitoylates the endoplasmic reticulum protein CKAP4 and regulates its localization to the plasma membrane (PubMed:18296695, PubMed:19144824). Could also palmitoylate LCK and regulate its localization to the plasma membrane (PubMed:22034844). {ECO:0000250|UniProtKB:P59267, ECO:0000250|UniProtKB:Q9JKR5, ECO:0000269|PubMed:18296695, ECO:0000269|PubMed:18508921, ECO:0000269|PubMed:19144824, ECO:0000269|PubMed:21343290, ECO:0000269|PubMed:22034844, ECO:0000269|PubMed:23793055}.; FUNCTION: (Microbial infection) Promotes Chikungunya virus (CHIKV) replication by mediating viral nsp1 palmitoylation. {ECO:0000269|PubMed:30404808}. |
| Q9UJX6 | ANAPC2 | S534 | ochoa | Anaphase-promoting complex subunit 2 (APC2) (Cyclosome subunit 2) | Together with the RING-H2 protein ANAPC11, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:11739784, PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:11739784, PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons (By similarity). CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation (By similarity). {ECO:0000250|UniProtKB:Q8BZQ7, ECO:0000269|PubMed:11739784, ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
| Q9UK39 | NOCT | S33 | ochoa | Nocturnin (EC 3.1.3.108) (Carbon catabolite repression 4-like protein) | Phosphatase which catalyzes the conversion of NADP(+) to NAD(+) and of NADPH to NADH (PubMed:31147539). Shows a small preference for NADPH over NADP(+) (PubMed:31147539). Represses translation and promotes degradation of target mRNA molecules (PubMed:29860338). Plays an important role in post-transcriptional regulation of metabolic genes under circadian control (By similarity). Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis (By similarity). Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance (By similarity). Promotes adipogenesis by facilitating PPARG nuclear translocation which activates its transcriptional activity (By similarity). Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone (By similarity). Critical for proper development of early embryos (By similarity). {ECO:0000250|UniProtKB:O35710, ECO:0000269|PubMed:29860338, ECO:0000269|PubMed:31147539}. |
| Q9ULH7 | MRTFB | S66 | ochoa | Myocardin-related transcription factor B (MRTF-B) (MKL/myocardin-like protein 2) (Megakaryoblastic leukemia 2) | Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation. {ECO:0000269|PubMed:14565952}. |
| Q9UNS1 | TIMELESS | S1087 | ochoa | Protein timeless homolog (hTIM) | Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication, DNA repair and in the regulation of the circadian clock (PubMed:17141802, PubMed:17296725, PubMed:23359676, PubMed:23418588, PubMed:26344098, PubMed:31138685, PubMed:32705708, PubMed:35585232, PubMed:9856465). Required to stabilize replication forks during DNA replication by forming a complex with TIPIN: this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress (PubMed:17141802, PubMed:17296725, PubMed:23359676, PubMed:35585232). During DNA replication, inhibits the CMG complex ATPase activity and activates DNA polymerases catalytic activities, coupling DNA unwinding and DNA synthesis (PubMed:23359676). TIMELESS promotes TIPIN nuclear localization (PubMed:17141802, PubMed:17296725). Plays a role in maintaining processive DNA replication past genomic guanine-rich DNA sequences that form G-quadruplex (G4) structures, possibly together with DDX1 (PubMed:32705708). Involved in cell survival after DNA damage or replication stress by promoting DNA repair (PubMed:17141802, PubMed:17296725, PubMed:26344098, PubMed:30356214). In response to double-strand breaks (DSBs), accumulates at DNA damage sites and promotes homologous recombination repair via its interaction with PARP1 (PubMed:26344098, PubMed:30356214, PubMed:31138685). May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light (PubMed:15798197). Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock (PubMed:23418588, PubMed:31138685). Negatively regulates CLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus (PubMed:31138685, PubMed:9856465). May play a role as destabilizer of the PER2-CRY2 complex (PubMed:31138685). May also play an important role in epithelial cell morphogenesis and formation of branching tubules (By similarity). {ECO:0000250|UniProtKB:Q9R1X4, ECO:0000269|PubMed:15798197, ECO:0000269|PubMed:17141802, ECO:0000269|PubMed:17296725, ECO:0000269|PubMed:23359676, ECO:0000269|PubMed:23418588, ECO:0000269|PubMed:26344098, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:31138685, ECO:0000269|PubMed:32705708, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9856465}. |
| Q9UNY4 | TTF2 | S883 | ochoa | Transcription termination factor 2 (EC 3.6.4.-) (Lodestar homolog) (RNA polymerase II termination factor) (Transcription release factor 2) (F2) (HuF2) | DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing. {ECO:0000269|PubMed:10455150, ECO:0000269|PubMed:12927788, ECO:0000269|PubMed:15125840, ECO:0000269|PubMed:9748214}. |
| Q9UPT6 | MAPK8IP3 | S1191 | ochoa | C-Jun-amino-terminal kinase-interacting protein 3 (JIP-3) (JNK-interacting protein 3) (JNK MAP kinase scaffold protein 3) (Mitogen-activated protein kinase 8-interacting protein 3) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:12189133). May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Promotes neuronal axon elongation in a kinesin- and JNK-dependent manner. Activates cofilin at axon tips via local activation of JNK, thereby regulating filopodial dynamics and enhancing axon elongation. Its binding to kinesin heavy chains (KHC), promotes kinesin-1 motility along microtubules and is essential for axon elongation and regeneration. Regulates cortical neuronal migration by mediating NTRK2/TRKB anterograde axonal transport during brain development (By similarity). Acts as an adapter that bridges the interaction between NTRK2/TRKB and KLC1 and drives NTRK2/TRKB axonal but not dendritic anterograde transport, which is essential for subsequent BDNF-triggered signaling and filopodia formation (PubMed:21775604). {ECO:0000250|UniProtKB:Q9ESN9, ECO:0000269|PubMed:12189133, ECO:0000269|PubMed:21775604}. |
| Q9Y3L3 | SH3BP1 | S262 | ochoa | SH3 domain-binding protein 1 | GTPase activating protein (GAP) which specifically converts GTP-bound Rho-type GTPases including RAC1 and CDC42 in their inactive GDP-bound form. By specifically inactivating RAC1 at the leading edge of migrating cells, it regulates the spatiotemporal organization of cell protrusions which is important for proper cell migration (PubMed:21658605). Also negatively regulates CDC42 in the process of actin remodeling and the formation of epithelial cell junctions (PubMed:22891260). Through its GAP activity toward RAC1 and/or CDC42 plays a specific role in phagocytosis of large particles. Specifically recruited by a PI3 kinase/PI3K-dependent mechanism to sites of large particles engagement, inactivates RAC1 and/or CDC42 allowing the reorganization of the underlying actin cytoskeleton required for engulfment (PubMed:26465210). It also plays a role in angiogenesis and the process of repulsive guidance as part of a semaphorin-plexin signaling pathway. Following the binding of PLXND1 to extracellular SEMA3E it dissociates from PLXND1 and inactivates RAC1, inducing the intracellular reorganization of the actin cytoskeleton and the collapse of cells (PubMed:24841563). {ECO:0000269|PubMed:21658605, ECO:0000269|PubMed:22891260, ECO:0000269|PubMed:24841563, ECO:0000269|PubMed:26465210}. |
| Q9Y4A5 | TRRAP | S1628 | ochoa | Transformation/transcription domain-associated protein (350/400 kDa PCAF-associated factor) (PAF350/400) (STAF40) (Tra1 homolog) | Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. Probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Probably not required in the steps following histone acetylation in processes of transcription activation. May be required for the mitotic checkpoint and normal cell cycle progression. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. May play a role in the formation and maintenance of the auditory system (By similarity). {ECO:0000250|UniProtKB:A0A0R4ITC5, ECO:0000269|PubMed:11418595, ECO:0000269|PubMed:12138177, ECO:0000269|PubMed:12660246, ECO:0000269|PubMed:12743606, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:17967892, ECO:0000269|PubMed:24463511, ECO:0000269|PubMed:9708738}. |
| Q9Y6D9 | MAD1L1 | S428 | ochoa|psp | Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient 1-like protein 1) (MAD1-like protein 1) (Mitotic checkpoint MAD1 protein homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181) | Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate (PubMed:10049595, PubMed:20133940, PubMed:29162720). Forms a heterotetrameric complex with the closed conformation form of MAD2L1 (C-MAD2) at unattached kinetochores during prometaphase, recruits an open conformation of MAD2L1 (O-MAD2) and promotes the conversion of O-MAD2 to C-MAD2, which ensures mitotic checkpoint signaling (PubMed:29162720). {ECO:0000269|PubMed:10049595, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:36322655}.; FUNCTION: [Isoform 3]: Sequesters MAD2L1 in the cytoplasm preventing its function as an activator of the mitotic spindle assembly checkpoint (SAC) resulting in SAC impairment and chromosomal instability in hepatocellular carcinomas. {ECO:0000269|PubMed:19010891}. |
| Q9Y6X6 | MYO16 | S1539 | ochoa | Unconventional myosin-XVI (Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 3) (Unconventional myosin-16) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. May be involved in targeting of the catalytic subunit of protein phosphatase 1 during brain development. Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis (By similarity). {ECO:0000250}. |
| P17174 | GOT1 | S93 | Sugiyama | Aspartate aminotransferase, cytoplasmic (cAspAT) (EC 2.6.1.1) (EC 2.6.1.3) (Cysteine aminotransferase, cytoplasmic) (Cysteine transaminase, cytoplasmic) (cCAT) (Glutamate oxaloacetate transaminase 1) (Transaminase A) | Biosynthesis of L-glutamate from L-aspartate or L-cysteine (PubMed:21900944). Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain. In addition, catalyzes (2S)-2-aminobutanoate, a by-product in the cysteine biosynthesis pathway (PubMed:27827456). {ECO:0000269|PubMed:16039064, ECO:0000269|PubMed:21900944, ECO:0000269|PubMed:27827456}. |
| Q8NFI4 | ST13P5 | S181 | Sugiyama | Putative protein FAM10A5 (Suppression of tumorigenicity 13 pseudogene 5) | None |
| P27448 | MARK3 | S400 | Sugiyama | MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (C-TAK1) (cTAK1) (Cdc25C-associated protein kinase 1) (ELKL motif kinase 2) (EMK-2) (Protein kinase STK10) (Ser/Thr protein kinase PAR-1) (Par-1a) (Serine/threonine-protein kinase p78) | Serine/threonine-protein kinase (PubMed:16822840, PubMed:16980613, PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Phosphorylates CDC25C on 'Ser-216' (PubMed:12941695). Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol (PubMed:16822840). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714). Phosphorylates PKP2 and KSR1 (PubMed:12941695). {ECO:0000269|PubMed:12941695, ECO:0000269|PubMed:16822840, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:23666762, ECO:0000269|PubMed:28087714}. |
| Q5JR12 | PPM1J | S93 | SIGNOR | Protein phosphatase 1J (EC 3.1.3.16) (Protein phosphatase 2C isoform zeta) (PP2C-zeta) | None |
| Q9BT78 | COPS4 | S298 | Sugiyama | COP9 signalosome complex subunit 4 (SGN4) (Signalosome subunit 4) (JAB1-containing signalosome subunit 4) | Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Also involved in the deneddylation of non-cullin subunits such as STON2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:21102408, ECO:0000269|PubMed:9535219}. |
| O43734 | TRAF3IP2 | S328 | SIGNOR | E3 ubiquitin ligase TRAF3IP2 (EC 2.3.2.27) (Adapter protein CIKS) (Connection to IKK and SAPK/JNK) (E3 ubiquitin-protein ligase CIKS) (Nuclear factor NF-kappa-B activator 1) (ACT1) (TRAF3-interacting protein 2) | E3 ubiquitin ligase that catalyzes 'Lys-63'-linked polyubiquitination of target protein, enhancing protein-protein interaction and cell signaling (PubMed:19825828). Transfers ubiquitin from E2 ubiquitin-conjugating enzyme UBE2V1-UBE2N to substrate protein (PubMed:19825828). Essential adapter molecule in IL17A-mediated signaling (PubMed:19825828, PubMed:24120361). Upon IL17A stimulation, interacts with IL17RA and IL17RC receptor chains through SEFIR domains and catalyzes 'Lys-63'-linked polyubiquitination of TRAF6, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways (PubMed:19825828). {ECO:0000269|PubMed:19825828, ECO:0000269|PubMed:24120361, ECO:0000269|PubMed:33723527}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-163765 | ChREBP activates metabolic gene expression | 2.133573e-08 | 7.671 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 2.097415e-04 | 3.678 |
| R-HSA-1266695 | Interleukin-7 signaling | 5.222381e-04 | 3.282 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 6.092699e-04 | 3.215 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 1.459991e-03 | 2.836 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 2.942443e-03 | 2.531 |
| R-HSA-9700206 | Signaling by ALK in cancer | 2.942443e-03 | 2.531 |
| R-HSA-9027283 | Erythropoietin activates STAT5 | 5.124687e-03 | 2.290 |
| R-HSA-9645135 | STAT5 Activation | 5.124687e-03 | 2.290 |
| R-HSA-429947 | Deadenylation of mRNA | 5.453149e-03 | 2.263 |
| R-HSA-390522 | Striated Muscle Contraction | 1.187843e-02 | 1.925 |
| R-HSA-381070 | IRE1alpha activates chaperones | 6.998125e-03 | 2.155 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 1.023180e-02 | 1.990 |
| R-HSA-2025928 | Calcineurin activates NFAT | 8.904499e-03 | 2.050 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 1.052772e-02 | 1.978 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 8.246363e-03 | 2.084 |
| R-HSA-9020958 | Interleukin-21 signaling | 8.904499e-03 | 2.050 |
| R-HSA-8985947 | Interleukin-9 signaling | 7.539474e-03 | 2.123 |
| R-HSA-2586552 | Signaling by Leptin | 1.037118e-02 | 1.984 |
| R-HSA-9020558 | Interleukin-2 signaling | 1.193700e-02 | 1.923 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 7.539474e-03 | 2.123 |
| R-HSA-210747 | Regulation of gene expression in early pancreatic precursor cells | 1.193700e-02 | 1.923 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 1.076919e-02 | 1.968 |
| R-HSA-163685 | Integration of energy metabolism | 9.638296e-03 | 2.016 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 1.101627e-02 | 1.958 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 1.919082e-02 | 1.717 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 1.914282e-02 | 1.718 |
| R-HSA-8983432 | Interleukin-15 signaling | 1.535620e-02 | 1.814 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 1.720476e-02 | 1.764 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 1.359948e-02 | 1.866 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 1.720476e-02 | 1.764 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 1.890692e-02 | 1.723 |
| R-HSA-9607240 | FLT3 Signaling | 1.919082e-02 | 1.717 |
| R-HSA-417957 | P2Y receptors | 1.914282e-02 | 1.718 |
| R-HSA-1170546 | Prolactin receptor signaling | 1.914282e-02 | 1.718 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 1.720476e-02 | 1.764 |
| R-HSA-9020591 | Interleukin-12 signaling | 1.751607e-02 | 1.757 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 2.308061e-02 | 1.637 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 2.308061e-02 | 1.637 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 2.547119e-02 | 1.594 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 2.514389e-02 | 1.600 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 2.514389e-02 | 1.600 |
| R-HSA-9702518 | STAT5 activation downstream of FLT3 ITD mutants | 2.547119e-02 | 1.594 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 2.547119e-02 | 1.594 |
| R-HSA-196780 | Biotin transport and metabolism | 2.116809e-02 | 1.674 |
| R-HSA-1433557 | Signaling by SCF-KIT | 2.244724e-02 | 1.649 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 2.850132e-02 | 1.545 |
| R-HSA-418038 | Nucleotide-like (purinergic) receptors | 3.009645e-02 | 1.521 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 3.009645e-02 | 1.521 |
| R-HSA-9909396 | Circadian clock | 3.072986e-02 | 1.512 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 2.843608e-02 | 1.546 |
| R-HSA-447115 | Interleukin-12 family signaling | 2.687483e-02 | 1.571 |
| R-HSA-4755609 | Defective DHDDS causes RP59 | 4.563127e-02 | 1.341 |
| R-HSA-9754119 | Drug-mediated inhibition of CDK4/CDK6 activity | 6.766409e-02 | 1.170 |
| R-HSA-5579024 | Defective MAT1A causes MATD | 6.766409e-02 | 1.170 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 8.919090e-02 | 1.050 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 1.102233e-01 | 0.958 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 1.102233e-01 | 0.958 |
| R-HSA-446107 | Type I hemidesmosome assembly | 1.205576e-01 | 0.919 |
| R-HSA-196025 | Formation of annular gap junctions | 1.205576e-01 | 0.919 |
| R-HSA-190873 | Gap junction degradation | 1.307725e-01 | 0.883 |
| R-HSA-9700645 | ALK mutants bind TKIs | 1.307725e-01 | 0.883 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 3.760137e-02 | 1.425 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 1.508495e-01 | 0.821 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 1.607144e-01 | 0.794 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 1.704653e-01 | 0.768 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 1.704653e-01 | 0.768 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 1.704653e-01 | 0.768 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 1.704653e-01 | 0.768 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 1.704653e-01 | 0.768 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 1.704653e-01 | 0.768 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 1.801035e-01 | 0.744 |
| R-HSA-177504 | Retrograde neurotrophin signalling | 1.896303e-01 | 0.722 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 1.990470e-01 | 0.701 |
| R-HSA-176412 | Phosphorylation of the APC/C | 2.083548e-01 | 0.681 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 2.083548e-01 | 0.681 |
| R-HSA-168275 | Entry of Influenza Virion into Host Cell via Endocytosis | 2.083548e-01 | 0.681 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 2.445225e-01 | 0.612 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 2.445225e-01 | 0.612 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 2.445225e-01 | 0.612 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 2.533046e-01 | 0.596 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 2.533046e-01 | 0.596 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.533046e-01 | 0.596 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.533046e-01 | 0.596 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 1.318145e-01 | 0.880 |
| R-HSA-6803529 | FGFR2 alternative splicing | 2.790461e-01 | 0.554 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 8.055178e-02 | 1.094 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 2.874290e-01 | 0.541 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 2.874290e-01 | 0.541 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 1.557804e-01 | 0.807 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 1.598530e-01 | 0.796 |
| R-HSA-72649 | Translation initiation complex formation | 1.639452e-01 | 0.785 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 3.039049e-01 | 0.517 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 1.680561e-01 | 0.775 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 1.008890e-01 | 0.996 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 1.721845e-01 | 0.764 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 1.721845e-01 | 0.764 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 1.804904e-01 | 0.744 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 3.200018e-01 | 0.495 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 3.200018e-01 | 0.495 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 3.279109e-01 | 0.484 |
| R-HSA-167287 | HIV elongation arrest and recovery | 3.279109e-01 | 0.484 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 3.279109e-01 | 0.484 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 3.279109e-01 | 0.484 |
| R-HSA-9615710 | Late endosomal microautophagy | 3.357284e-01 | 0.474 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 3.357284e-01 | 0.474 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 3.434555e-01 | 0.464 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 3.510932e-01 | 0.455 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 3.510932e-01 | 0.455 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 3.661045e-01 | 0.436 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 3.661045e-01 | 0.436 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 3.734801e-01 | 0.428 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 2.528128e-01 | 0.597 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 3.879761e-01 | 0.411 |
| R-HSA-72086 | mRNA Capping | 3.357284e-01 | 0.474 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 7.849002e-02 | 1.105 |
| R-HSA-9762292 | Regulation of CDH11 function | 1.408693e-01 | 0.851 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 9.417973e-02 | 1.026 |
| R-HSA-437239 | Recycling pathway of L1 | 1.357475e-01 | 0.867 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 3.807703e-01 | 0.419 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 2.356205e-01 | 0.628 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 2.356205e-01 | 0.628 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 2.445225e-01 | 0.612 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 1.008890e-01 | 0.996 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 1.550103e-01 | 0.810 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 1.550103e-01 | 0.810 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 1.318145e-01 | 0.880 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 1.318145e-01 | 0.880 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 1.318145e-01 | 0.880 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 8.711495e-02 | 1.060 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 6.689533e-02 | 1.175 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 2.266489e-01 | 0.645 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 3.661045e-01 | 0.436 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 4.021385e-01 | 0.396 |
| R-HSA-2467813 | Separation of Sister Chromatids | 6.353464e-02 | 1.197 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 1.833980e-01 | 0.737 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 3.734801e-01 | 0.428 |
| R-HSA-5221030 | TET1,2,3 and TDG demethylate DNA | 1.408693e-01 | 0.851 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 2.175551e-01 | 0.662 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 2.958438e-01 | 0.529 |
| R-HSA-5673000 | RAF activation | 8.360788e-02 | 1.078 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 3.661045e-01 | 0.436 |
| R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 2.957148e-01 | 0.529 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 1.598530e-01 | 0.796 |
| R-HSA-525793 | Myogenesis | 3.120002e-01 | 0.506 |
| R-HSA-6802949 | Signaling by RAS mutants | 1.318145e-01 | 0.880 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 4.858187e-02 | 1.314 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 1.846661e-01 | 0.734 |
| R-HSA-5693538 | Homology Directed Repair | 2.010502e-01 | 0.697 |
| R-HSA-3249367 | STAT6-mediated induction of chemokines | 5.671167e-02 | 1.246 |
| R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 1.408693e-01 | 0.851 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 1.704653e-01 | 0.768 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 1.801035e-01 | 0.744 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 9.061391e-02 | 1.043 |
| R-HSA-8851708 | Signaling by FGFR2 IIIa TM | 2.445225e-01 | 0.612 |
| R-HSA-9764561 | Regulation of CDH1 Function | 1.763296e-01 | 0.754 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 1.804904e-01 | 0.744 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 1.930582e-01 | 0.714 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 3.734801e-01 | 0.428 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 3.807703e-01 | 0.419 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 4.021385e-01 | 0.396 |
| R-HSA-5696398 | Nucleotide Excision Repair | 1.577839e-01 | 0.802 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 2.356377e-01 | 0.628 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 1.412580e-01 | 0.850 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 4.024606e-02 | 1.395 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 5.445508e-02 | 1.264 |
| R-HSA-5693606 | DNA Double Strand Break Response | 2.185006e-01 | 0.661 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 6.370286e-02 | 1.196 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 3.734801e-01 | 0.428 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 6.811264e-02 | 1.167 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 7.343510e-02 | 1.134 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 2.083548e-01 | 0.681 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 3.120002e-01 | 0.506 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 2.399135e-01 | 0.620 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 3.734801e-01 | 0.428 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 2.705652e-01 | 0.568 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 4.295898e-02 | 1.367 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 7.013995e-02 | 1.154 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 1.972730e-01 | 0.705 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 3.286949e-01 | 0.483 |
| R-HSA-2132295 | MHC class II antigen presentation | 2.160552e-01 | 0.665 |
| R-HSA-74713 | IRS activation | 7.849002e-02 | 1.105 |
| R-HSA-9834899 | Specification of the neural plate border | 2.445225e-01 | 0.612 |
| R-HSA-429958 | mRNA decay by 3' to 5' exoribonuclease | 2.445225e-01 | 0.612 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 3.807703e-01 | 0.419 |
| R-HSA-68877 | Mitotic Prometaphase | 1.041819e-01 | 0.982 |
| R-HSA-4791275 | Signaling by WNT in cancer | 3.586425e-01 | 0.445 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 7.474420e-02 | 1.126 |
| R-HSA-200425 | Carnitine shuttle | 4.573822e-02 | 1.340 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 2.957148e-01 | 0.529 |
| R-HSA-8953854 | Metabolism of RNA | 2.993085e-01 | 0.524 |
| R-HSA-9682385 | FLT3 signaling in disease | 9.061391e-02 | 1.043 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 3.200018e-01 | 0.495 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 3.357284e-01 | 0.474 |
| R-HSA-180746 | Nuclear import of Rev protein | 3.807703e-01 | 0.419 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 3.879761e-01 | 0.411 |
| R-HSA-68882 | Mitotic Anaphase | 1.440140e-01 | 0.842 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 3.661045e-01 | 0.436 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 1.458013e-01 | 0.836 |
| R-HSA-451927 | Interleukin-2 family signaling | 1.051115e-01 | 0.978 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 3.886256e-01 | 0.410 |
| R-HSA-3371599 | Defective HLCS causes multiple carboxylase deficiency | 1.102233e-01 | 0.958 |
| R-HSA-198693 | AKT phosphorylates targets in the nucleus | 1.307725e-01 | 0.883 |
| R-HSA-9796292 | Formation of axial mesoderm | 1.801035e-01 | 0.744 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 2.485103e-01 | 0.605 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 1.088289e-01 | 0.963 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 2.743414e-01 | 0.562 |
| R-HSA-392518 | Signal amplification | 3.807703e-01 | 0.419 |
| R-HSA-73894 | DNA Repair | 1.585371e-01 | 0.800 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 8.919090e-02 | 1.050 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 1.508495e-01 | 0.821 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 8.017061e-02 | 1.096 |
| R-HSA-1483148 | Synthesis of PG | 2.175551e-01 | 0.662 |
| R-HSA-9766229 | Degradation of CDH1 | 1.436904e-01 | 0.843 |
| R-HSA-9836573 | Mitochondrial RNA degradation | 2.957148e-01 | 0.529 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 5.447739e-02 | 1.264 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 3.661045e-01 | 0.436 |
| R-HSA-68886 | M Phase | 3.317600e-01 | 0.479 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 3.807703e-01 | 0.419 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 7.421514e-02 | 1.130 |
| R-HSA-8963693 | Aspartate and asparagine metabolism | 3.510932e-01 | 0.455 |
| R-HSA-982772 | Growth hormone receptor signaling | 4.573822e-02 | 1.340 |
| R-HSA-1640170 | Cell Cycle | 3.469365e-01 | 0.460 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 2.160552e-01 | 0.665 |
| R-HSA-1483249 | Inositol phosphate metabolism | 1.776105e-01 | 0.751 |
| R-HSA-3323169 | Defects in biotin (Btn) metabolism | 1.307725e-01 | 0.883 |
| R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants | 1.704653e-01 | 0.768 |
| R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer | 1.704653e-01 | 0.768 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 1.896303e-01 | 0.722 |
| R-HSA-1614517 | Sulfide oxidation to sulfate | 2.266489e-01 | 0.645 |
| R-HSA-211979 | Eicosanoids | 2.705652e-01 | 0.568 |
| R-HSA-5689901 | Metalloprotease DUBs | 3.120002e-01 | 0.506 |
| R-HSA-9845576 | Glycosphingolipid transport | 3.950985e-01 | 0.403 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 2.313320e-01 | 0.636 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 2.445225e-01 | 0.612 |
| R-HSA-9669938 | Signaling by KIT in disease | 4.295898e-02 | 1.367 |
| R-HSA-9823730 | Formation of definitive endoderm | 2.533046e-01 | 0.596 |
| R-HSA-9659379 | Sensory processing of sound | 8.271472e-02 | 1.082 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 3.044223e-01 | 0.517 |
| R-HSA-168255 | Influenza Infection | 2.021448e-01 | 0.694 |
| R-HSA-8877330 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | 1.801035e-01 | 0.744 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 2.705652e-01 | 0.568 |
| R-HSA-8964038 | LDL clearance | 2.790461e-01 | 0.554 |
| R-HSA-74749 | Signal attenuation | 1.408693e-01 | 0.851 |
| R-HSA-9856872 | Malate-aspartate shuttle | 1.896303e-01 | 0.722 |
| R-HSA-1237112 | Methionine salvage pathway | 2.445225e-01 | 0.612 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 6.035278e-02 | 1.219 |
| R-HSA-1855183 | Synthesis of IP2, IP, and Ins in the cytosol | 3.120002e-01 | 0.506 |
| R-HSA-69620 | Cell Cycle Checkpoints | 4.593472e-02 | 1.338 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 3.803801e-01 | 0.420 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 2.313320e-01 | 0.636 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 3.886256e-01 | 0.410 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 2.313320e-01 | 0.636 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 1.163661e-01 | 0.934 |
| R-HSA-70171 | Glycolysis | 3.720887e-01 | 0.429 |
| R-HSA-3247509 | Chromatin modifying enzymes | 1.775839e-01 | 0.751 |
| R-HSA-2262752 | Cellular responses to stress | 2.340046e-01 | 0.631 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 3.980285e-02 | 1.400 |
| R-HSA-166208 | mTORC1-mediated signalling | 2.790461e-01 | 0.554 |
| R-HSA-446199 | Synthesis of dolichyl-phosphate | 2.957148e-01 | 0.529 |
| R-HSA-203927 | MicroRNA (miRNA) biogenesis | 3.039049e-01 | 0.517 |
| R-HSA-8953897 | Cellular responses to stimuli | 2.041152e-01 | 0.690 |
| R-HSA-9006335 | Signaling by Erythropoietin | 6.370286e-02 | 1.196 |
| R-HSA-3214842 | HDMs demethylate histones | 3.039049e-01 | 0.517 |
| R-HSA-4839726 | Chromatin organization | 2.075984e-01 | 0.683 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 8.017061e-02 | 1.096 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 1.008890e-01 | 0.996 |
| R-HSA-74160 | Gene expression (Transcription) | 1.711962e-01 | 0.767 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 6.613178e-02 | 1.180 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 4.295898e-02 | 1.367 |
| R-HSA-9830364 | Formation of the nephric duct | 3.039049e-01 | 0.517 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 3.120002e-01 | 0.506 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 1.205576e-01 | 0.919 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 2.705652e-01 | 0.568 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 3.879761e-01 | 0.411 |
| R-HSA-2408508 | Metabolism of ingested SeMet, Sec, MeSec into H2Se | 3.879761e-01 | 0.411 |
| R-HSA-73857 | RNA Polymerase II Transcription | 1.453271e-01 | 0.838 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 3.661045e-01 | 0.436 |
| R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 2.619851e-01 | 0.582 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 3.039049e-01 | 0.517 |
| R-HSA-9733709 | Cardiogenesis | 3.661045e-01 | 0.436 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 1.387105e-01 | 0.858 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 4.295898e-02 | 1.367 |
| R-HSA-5683826 | Surfactant metabolism | 1.240313e-01 | 0.906 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 2.790461e-01 | 0.554 |
| R-HSA-3000170 | Syndecan interactions | 2.874290e-01 | 0.541 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 3.039049e-01 | 0.517 |
| R-HSA-3000157 | Laminin interactions | 3.039049e-01 | 0.517 |
| R-HSA-186763 | Downstream signal transduction | 7.013995e-02 | 1.154 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 1.397065e-01 | 0.855 |
| R-HSA-5609975 | Diseases associated with glycosylation precursor biosynthesis | 3.661045e-01 | 0.436 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 3.734801e-01 | 0.428 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 3.128124e-01 | 0.505 |
| R-HSA-5633007 | Regulation of TP53 Activity | 1.562776e-01 | 0.806 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 1.014299e-01 | 0.994 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 8.360788e-02 | 1.078 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 2.874290e-01 | 0.541 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 3.120002e-01 | 0.506 |
| R-HSA-1839126 | FGFR2 mutant receptor activation | 3.950985e-01 | 0.403 |
| R-HSA-8854691 | Interleukin-20 family signaling | 4.573822e-02 | 1.340 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 4.573822e-02 | 1.340 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 3.039049e-01 | 0.517 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 3.039049e-01 | 0.517 |
| R-HSA-3296482 | Defects in vitamin and cofactor metabolism | 3.879761e-01 | 0.411 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 2.915487e-01 | 0.535 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 3.120002e-01 | 0.506 |
| R-HSA-212436 | Generic Transcription Pathway | 1.546830e-01 | 0.811 |
| R-HSA-1980145 | Signaling by NOTCH2 | 3.807703e-01 | 0.419 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 3.553776e-01 | 0.449 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 1.557804e-01 | 0.807 |
| R-HSA-8853659 | RET signaling | 3.950985e-01 | 0.403 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 3.344151e-01 | 0.476 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 7.677917e-02 | 1.115 |
| R-HSA-186712 | Regulation of beta-cell development | 1.846661e-01 | 0.734 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 2.614229e-01 | 0.583 |
| R-HSA-186797 | Signaling by PDGF | 1.972730e-01 | 0.705 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 2.528128e-01 | 0.597 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 1.125809e-01 | 0.949 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 3.586425e-01 | 0.445 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 1.763296e-01 | 0.754 |
| R-HSA-8957322 | Metabolism of steroids | 2.157161e-01 | 0.666 |
| R-HSA-1226099 | Signaling by FGFR in disease | 7.215459e-02 | 1.142 |
| R-HSA-611105 | Respiratory electron transport | 4.044344e-01 | 0.393 |
| R-HSA-211000 | Gene Silencing by RNA | 4.049694e-01 | 0.393 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 4.090232e-01 | 0.388 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 4.090232e-01 | 0.388 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 4.090970e-01 | 0.388 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 4.090970e-01 | 0.388 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 4.159749e-01 | 0.381 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 4.159749e-01 | 0.381 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 4.159749e-01 | 0.381 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 4.159749e-01 | 0.381 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 4.159749e-01 | 0.381 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 4.159749e-01 | 0.381 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 4.199579e-01 | 0.377 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 4.227732e-01 | 0.374 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 4.227732e-01 | 0.374 |
| R-HSA-167169 | HIV Transcription Elongation | 4.227732e-01 | 0.374 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 4.227732e-01 | 0.374 |
| R-HSA-9646399 | Aggrephagy | 4.227732e-01 | 0.374 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 4.227732e-01 | 0.374 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 4.227732e-01 | 0.374 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 4.227732e-01 | 0.374 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 4.227732e-01 | 0.374 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 4.227732e-01 | 0.374 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 4.251023e-01 | 0.372 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 4.251023e-01 | 0.372 |
| R-HSA-5683057 | MAPK family signaling cascades | 4.272272e-01 | 0.369 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 4.294927e-01 | 0.367 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 4.294927e-01 | 0.367 |
| R-HSA-9694548 | Maturation of spike protein | 4.294927e-01 | 0.367 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 4.294927e-01 | 0.367 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 4.330570e-01 | 0.363 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 4.361345e-01 | 0.360 |
| R-HSA-167161 | HIV Transcription Initiation | 4.361345e-01 | 0.360 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 4.361345e-01 | 0.360 |
| R-HSA-5674135 | MAP2K and MAPK activation | 4.361345e-01 | 0.360 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 4.361345e-01 | 0.360 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 4.361345e-01 | 0.360 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 4.361345e-01 | 0.360 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 4.426993e-01 | 0.354 |
| R-HSA-165159 | MTOR signalling | 4.426993e-01 | 0.354 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 4.448786e-01 | 0.352 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 4.487889e-01 | 0.348 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 4.487889e-01 | 0.348 |
| R-HSA-373760 | L1CAM interactions | 4.487889e-01 | 0.348 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 4.491881e-01 | 0.348 |
| R-HSA-70326 | Glucose metabolism | 4.526837e-01 | 0.344 |
| R-HSA-69231 | Cyclin D associated events in G1 | 4.556017e-01 | 0.341 |
| R-HSA-69236 | G1 Phase | 4.556017e-01 | 0.341 |
| R-HSA-190828 | Gap junction trafficking | 4.556017e-01 | 0.341 |
| R-HSA-3214858 | RMTs methylate histone arginines | 4.556017e-01 | 0.341 |
| R-HSA-156581 | Methylation | 4.556017e-01 | 0.341 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 4.619411e-01 | 0.335 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 4.619411e-01 | 0.335 |
| R-HSA-9824272 | Somitogenesis | 4.619411e-01 | 0.335 |
| R-HSA-1614558 | Degradation of cysteine and homocysteine | 4.619411e-01 | 0.335 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 4.619411e-01 | 0.335 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 4.623685e-01 | 0.335 |
| R-HSA-3371556 | Cellular response to heat stress | 4.681056e-01 | 0.330 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 4.682070e-01 | 0.330 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 4.682070e-01 | 0.330 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 4.682070e-01 | 0.330 |
| R-HSA-9675135 | Diseases of DNA repair | 4.682070e-01 | 0.330 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 4.682070e-01 | 0.330 |
| R-HSA-75153 | Apoptotic execution phase | 4.682070e-01 | 0.330 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 4.744003e-01 | 0.324 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 4.744003e-01 | 0.324 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 4.744003e-01 | 0.324 |
| R-HSA-9031628 | NGF-stimulated transcription | 4.805219e-01 | 0.318 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 4.805466e-01 | 0.318 |
| R-HSA-449147 | Signaling by Interleukins | 4.831147e-01 | 0.316 |
| R-HSA-157858 | Gap junction trafficking and regulation | 4.865726e-01 | 0.313 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 4.876306e-01 | 0.312 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 4.925532e-01 | 0.308 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 4.925532e-01 | 0.308 |
| R-HSA-2162123 | Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | 4.925532e-01 | 0.308 |
| R-HSA-69481 | G2/M Checkpoints | 4.944647e-01 | 0.306 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 4.981628e-01 | 0.303 |
| R-HSA-912446 | Meiotic recombination | 4.984644e-01 | 0.302 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 5.043072e-01 | 0.297 |
| R-HSA-72187 | mRNA 3'-end processing | 5.043072e-01 | 0.297 |
| R-HSA-6794361 | Neurexins and neuroligins | 5.043072e-01 | 0.297 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 5.050295e-01 | 0.297 |
| R-HSA-397014 | Muscle contraction | 5.097278e-01 | 0.293 |
| R-HSA-195721 | Signaling by WNT | 5.099536e-01 | 0.292 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 5.100822e-01 | 0.292 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 5.100822e-01 | 0.292 |
| R-HSA-1221632 | Meiotic synapsis | 5.100822e-01 | 0.292 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 5.100822e-01 | 0.292 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 5.157904e-01 | 0.288 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 5.157904e-01 | 0.288 |
| R-HSA-9012852 | Signaling by NOTCH3 | 5.214323e-01 | 0.283 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 5.270089e-01 | 0.278 |
| R-HSA-69278 | Cell Cycle, Mitotic | 5.305950e-01 | 0.275 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 5.325208e-01 | 0.274 |
| R-HSA-1483166 | Synthesis of PA | 5.325208e-01 | 0.274 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 5.341834e-01 | 0.272 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 5.341834e-01 | 0.272 |
| R-HSA-8951664 | Neddylation | 5.352478e-01 | 0.271 |
| R-HSA-6782135 | Dual incision in TC-NER | 5.379689e-01 | 0.269 |
| R-HSA-191859 | snRNP Assembly | 5.433538e-01 | 0.265 |
| R-HSA-194441 | Metabolism of non-coding RNA | 5.433538e-01 | 0.265 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 5.433538e-01 | 0.265 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 5.486762e-01 | 0.261 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 5.486762e-01 | 0.261 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 5.486762e-01 | 0.261 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 5.486762e-01 | 0.261 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 5.486762e-01 | 0.261 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 5.491000e-01 | 0.260 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 5.539370e-01 | 0.257 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 5.539370e-01 | 0.257 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 5.583315e-01 | 0.253 |
| R-HSA-6784531 | tRNA processing in the nucleus | 5.591367e-01 | 0.252 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 5.591367e-01 | 0.252 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 5.617082e-01 | 0.250 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 5.642762e-01 | 0.249 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 5.642762e-01 | 0.249 |
| R-HSA-6799198 | Complex I biogenesis | 5.642762e-01 | 0.249 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 5.642762e-01 | 0.249 |
| R-HSA-74751 | Insulin receptor signalling cascade | 5.693560e-01 | 0.245 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 5.743770e-01 | 0.241 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 5.750309e-01 | 0.240 |
| R-HSA-166520 | Signaling by NTRKs | 5.783155e-01 | 0.238 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 5.793397e-01 | 0.237 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 5.793397e-01 | 0.237 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 5.842448e-01 | 0.233 |
| R-HSA-9830369 | Kidney development | 5.842448e-01 | 0.233 |
| R-HSA-196807 | Nicotinate metabolism | 5.842448e-01 | 0.233 |
| R-HSA-167172 | Transcription of the HIV genome | 5.890931e-01 | 0.230 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 5.986215e-01 | 0.223 |
| R-HSA-204005 | COPII-mediated vesicle transport | 5.986215e-01 | 0.223 |
| R-HSA-162587 | HIV Life Cycle | 6.070430e-01 | 0.217 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 6.079301e-01 | 0.216 |
| R-HSA-9711097 | Cellular response to starvation | 6.101422e-01 | 0.215 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 6.101422e-01 | 0.215 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 6.122311e-01 | 0.213 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 6.125036e-01 | 0.213 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 6.125036e-01 | 0.213 |
| R-HSA-4086398 | Ca2+ pathway | 6.125036e-01 | 0.213 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 6.125036e-01 | 0.213 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 6.170240e-01 | 0.210 |
| R-HSA-1236394 | Signaling by ERBB4 | 6.170240e-01 | 0.210 |
| R-HSA-380287 | Centrosome maturation | 6.214919e-01 | 0.207 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 6.214919e-01 | 0.207 |
| R-HSA-5688426 | Deubiquitination | 6.244684e-01 | 0.204 |
| R-HSA-5689603 | UCH proteinases | 6.259080e-01 | 0.203 |
| R-HSA-1980143 | Signaling by NOTCH1 | 6.259080e-01 | 0.203 |
| R-HSA-2408522 | Selenoamino acid metabolism | 6.283490e-01 | 0.202 |
| R-HSA-9694635 | Translation of Structural Proteins | 6.302729e-01 | 0.200 |
| R-HSA-4086400 | PCP/CE pathway | 6.345870e-01 | 0.198 |
| R-HSA-5579029 | Metabolic disorders of biological oxidation enzymes | 6.388512e-01 | 0.195 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 6.430658e-01 | 0.192 |
| R-HSA-5654738 | Signaling by FGFR2 | 6.430658e-01 | 0.192 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 6.487521e-01 | 0.188 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 6.513488e-01 | 0.186 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 6.513488e-01 | 0.186 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 6.515937e-01 | 0.186 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 6.558851e-01 | 0.183 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 6.572222e-01 | 0.182 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 6.572222e-01 | 0.182 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 6.578899e-01 | 0.182 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 6.594405e-01 | 0.181 |
| R-HSA-1500620 | Meiosis | 6.634161e-01 | 0.178 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 6.634161e-01 | 0.178 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 6.634161e-01 | 0.178 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 6.750679e-01 | 0.171 |
| R-HSA-2559583 | Cellular Senescence | 6.763533e-01 | 0.170 |
| R-HSA-446728 | Cell junction organization | 6.778480e-01 | 0.169 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 6.788620e-01 | 0.168 |
| R-HSA-156902 | Peptide chain elongation | 6.788620e-01 | 0.168 |
| R-HSA-9663891 | Selective autophagy | 6.788620e-01 | 0.168 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 6.863185e-01 | 0.163 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 6.865401e-01 | 0.163 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 6.899819e-01 | 0.161 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 6.936027e-01 | 0.159 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 6.963386e-01 | 0.157 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 6.971502e-01 | 0.157 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 6.971815e-01 | 0.157 |
| R-HSA-74752 | Signaling by Insulin receptor | 6.971815e-01 | 0.157 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 6.971815e-01 | 0.157 |
| R-HSA-391251 | Protein folding | 6.971815e-01 | 0.157 |
| R-HSA-2682334 | EPH-Ephrin signaling | 6.971815e-01 | 0.157 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 6.971815e-01 | 0.157 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 7.007186e-01 | 0.154 |
| R-HSA-1266738 | Developmental Biology | 7.024207e-01 | 0.153 |
| R-HSA-9837999 | Mitochondrial protein degradation | 7.042147e-01 | 0.152 |
| R-HSA-1474290 | Collagen formation | 7.042147e-01 | 0.152 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 7.076702e-01 | 0.150 |
| R-HSA-9675108 | Nervous system development | 7.092809e-01 | 0.149 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 7.110855e-01 | 0.148 |
| R-HSA-72764 | Eukaryotic Translation Termination | 7.110855e-01 | 0.148 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 7.120165e-01 | 0.148 |
| R-HSA-5389840 | Mitochondrial translation elongation | 7.144611e-01 | 0.146 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 7.144611e-01 | 0.146 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 7.144611e-01 | 0.146 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 7.144611e-01 | 0.146 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 7.168352e-01 | 0.145 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 7.177975e-01 | 0.144 |
| R-HSA-157579 | Telomere Maintenance | 7.177975e-01 | 0.144 |
| R-HSA-5368286 | Mitochondrial translation initiation | 7.210951e-01 | 0.142 |
| R-HSA-190236 | Signaling by FGFR | 7.210951e-01 | 0.142 |
| R-HSA-3214847 | HATs acetylate histones | 7.243544e-01 | 0.140 |
| R-HSA-9614085 | FOXO-mediated transcription | 7.243544e-01 | 0.140 |
| R-HSA-2408557 | Selenocysteine synthesis | 7.307597e-01 | 0.136 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 7.308883e-01 | 0.136 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 7.339066e-01 | 0.134 |
| R-HSA-1483255 | PI Metabolism | 7.339066e-01 | 0.134 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 7.370169e-01 | 0.133 |
| R-HSA-192823 | Viral mRNA Translation | 7.370169e-01 | 0.133 |
| R-HSA-72172 | mRNA Splicing | 7.376915e-01 | 0.132 |
| R-HSA-8978868 | Fatty acid metabolism | 7.383060e-01 | 0.132 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 7.400911e-01 | 0.131 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 7.491007e-01 | 0.125 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 7.520344e-01 | 0.124 |
| R-HSA-69239 | Synthesis of DNA | 7.520344e-01 | 0.124 |
| R-HSA-1500931 | Cell-Cell communication | 7.534388e-01 | 0.123 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 7.549339e-01 | 0.122 |
| R-HSA-5419276 | Mitochondrial translation termination | 7.577997e-01 | 0.120 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 7.577997e-01 | 0.120 |
| R-HSA-418990 | Adherens junctions interactions | 7.675367e-01 | 0.115 |
| R-HSA-162582 | Signal Transduction | 7.747102e-01 | 0.111 |
| R-HSA-1474244 | Extracellular matrix organization | 7.791055e-01 | 0.108 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 7.795578e-01 | 0.108 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 7.795578e-01 | 0.108 |
| R-HSA-2980736 | Peptide hormone metabolism | 7.846863e-01 | 0.105 |
| R-HSA-162906 | HIV Infection | 7.851352e-01 | 0.105 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 7.870169e-01 | 0.104 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 7.872059e-01 | 0.104 |
| R-HSA-68875 | Mitotic Prophase | 7.921575e-01 | 0.101 |
| R-HSA-72312 | rRNA processing | 7.944005e-01 | 0.100 |
| R-HSA-73886 | Chromosome Maintenance | 7.945901e-01 | 0.100 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 7.949742e-01 | 0.100 |
| R-HSA-199991 | Membrane Trafficking | 7.966171e-01 | 0.099 |
| R-HSA-162909 | Host Interactions of HIV factors | 8.017193e-01 | 0.096 |
| R-HSA-8939211 | ESR-mediated signaling | 8.033130e-01 | 0.095 |
| R-HSA-1280218 | Adaptive Immune System | 8.044075e-01 | 0.095 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 8.063348e-01 | 0.093 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 8.063348e-01 | 0.093 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 8.063348e-01 | 0.093 |
| R-HSA-194138 | Signaling by VEGF | 8.063348e-01 | 0.093 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 8.069795e-01 | 0.093 |
| R-HSA-114608 | Platelet degranulation | 8.108435e-01 | 0.091 |
| R-HSA-1474165 | Reproduction | 8.195500e-01 | 0.086 |
| R-HSA-9843745 | Adipogenesis | 8.216635e-01 | 0.085 |
| R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 8.216635e-01 | 0.085 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 8.237525e-01 | 0.084 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 8.258171e-01 | 0.083 |
| R-HSA-421270 | Cell-cell junction organization | 8.264756e-01 | 0.083 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 8.287729e-01 | 0.082 |
| R-HSA-5368287 | Mitochondrial translation | 8.377093e-01 | 0.077 |
| R-HSA-9948299 | Ribosome-associated quality control | 8.377093e-01 | 0.077 |
| R-HSA-1632852 | Macroautophagy | 8.433489e-01 | 0.074 |
| R-HSA-416476 | G alpha (q) signalling events | 8.457675e-01 | 0.073 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 8.469999e-01 | 0.072 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 8.505663e-01 | 0.070 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 8.540500e-01 | 0.069 |
| R-HSA-69242 | S Phase | 8.574528e-01 | 0.067 |
| R-HSA-9758941 | Gastrulation | 8.591246e-01 | 0.066 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 8.592660e-01 | 0.066 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 8.624097e-01 | 0.064 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 8.640236e-01 | 0.063 |
| R-HSA-2142753 | Arachidonate metabolism | 8.640236e-01 | 0.063 |
| R-HSA-69306 | DNA Replication | 8.656187e-01 | 0.063 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 8.671951e-01 | 0.062 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 8.671951e-01 | 0.062 |
| R-HSA-9612973 | Autophagy | 8.702931e-01 | 0.060 |
| R-HSA-9610379 | HCMV Late Events | 8.718150e-01 | 0.060 |
| R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 8.718150e-01 | 0.060 |
| R-HSA-109581 | Apoptosis | 8.791621e-01 | 0.056 |
| R-HSA-1483257 | Phospholipid metabolism | 8.841752e-01 | 0.053 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 8.860902e-01 | 0.053 |
| R-HSA-5619102 | SLC transporter disorders | 8.860902e-01 | 0.053 |
| R-HSA-72306 | tRNA processing | 8.913471e-01 | 0.050 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 8.924317e-01 | 0.049 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 8.938843e-01 | 0.049 |
| R-HSA-5689880 | Ub-specific processing proteases | 8.951307e-01 | 0.048 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 8.963626e-01 | 0.048 |
| R-HSA-5668914 | Diseases of metabolism | 8.967603e-01 | 0.047 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 8.975800e-01 | 0.047 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 8.975800e-01 | 0.047 |
| R-HSA-72766 | Translation | 8.984476e-01 | 0.047 |
| R-HSA-422475 | Axon guidance | 8.995095e-01 | 0.046 |
| R-HSA-3781865 | Diseases of glycosylation | 9.079164e-01 | 0.042 |
| R-HSA-69275 | G2/M Transition | 9.100686e-01 | 0.041 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 9.110907e-01 | 0.040 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 9.121707e-01 | 0.040 |
| R-HSA-5617833 | Cilium Assembly | 9.142239e-01 | 0.039 |
| R-HSA-9609690 | HCMV Early Events | 9.201015e-01 | 0.036 |
| R-HSA-392499 | Metabolism of proteins | 9.231530e-01 | 0.035 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 9.237956e-01 | 0.034 |
| R-HSA-389948 | Co-inhibition by PD-1 | 9.237956e-01 | 0.034 |
| R-HSA-5653656 | Vesicle-mediated transport | 9.250981e-01 | 0.034 |
| R-HSA-376176 | Signaling by ROBO receptors | 9.264542e-01 | 0.033 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 9.264542e-01 | 0.033 |
| R-HSA-5357801 | Programmed Cell Death | 9.290205e-01 | 0.032 |
| R-HSA-597592 | Post-translational protein modification | 9.335033e-01 | 0.030 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.428154e-01 | 0.026 |
| R-HSA-168256 | Immune System | 9.448752e-01 | 0.025 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 9.465894e-01 | 0.024 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 9.525636e-01 | 0.021 |
| R-HSA-157118 | Signaling by NOTCH | 9.531232e-01 | 0.021 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.559001e-01 | 0.020 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 9.568604e-01 | 0.019 |
| R-HSA-9609646 | HCMV Infection | 9.583700e-01 | 0.018 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 9.612332e-01 | 0.017 |
| R-HSA-9734767 | Developmental Cell Lineages | 9.643269e-01 | 0.016 |
| R-HSA-9679506 | SARS-CoV Infections | 9.658526e-01 | 0.015 |
| R-HSA-9711123 | Cellular response to chemical stress | 9.663851e-01 | 0.015 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 9.701538e-01 | 0.013 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 9.756207e-01 | 0.011 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.761259e-01 | 0.010 |
| R-HSA-6798695 | Neutrophil degranulation | 9.766076e-01 | 0.010 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 9.819020e-01 | 0.008 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 9.860813e-01 | 0.006 |
| R-HSA-211859 | Biological oxidations | 9.881599e-01 | 0.005 |
| R-HSA-168249 | Innate Immune System | 9.908688e-01 | 0.004 |
| R-HSA-913531 | Interferon Signaling | 9.915772e-01 | 0.004 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.922546e-01 | 0.003 |
| R-HSA-556833 | Metabolism of lipids | 9.933477e-01 | 0.003 |
| R-HSA-500792 | GPCR ligand binding | 9.940927e-01 | 0.003 |
| R-HSA-1643685 | Disease | 9.950115e-01 | 0.002 |
| R-HSA-109582 | Hemostasis | 9.961289e-01 | 0.002 |
| R-HSA-112316 | Neuronal System | 9.969648e-01 | 0.001 |
| R-HSA-9824446 | Viral Infection Pathways | 9.978388e-01 | 0.001 |
| R-HSA-388396 | GPCR downstream signalling | 9.992091e-01 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 9.994836e-01 | 0.000 |
| R-HSA-372790 | Signaling by GPCR | 9.996869e-01 | 0.000 |
| R-HSA-5663205 | Infectious disease | 9.999625e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999673e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999977e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CDK19 |
0.879 | 0.853 | 1 | 0.833 |
CDK18 |
0.877 | 0.864 | 1 | 0.849 |
CDK17 |
0.874 | 0.873 | 1 | 0.878 |
CDK8 |
0.874 | 0.853 | 1 | 0.800 |
P38G |
0.872 | 0.886 | 1 | 0.887 |
HIPK2 |
0.871 | 0.792 | 1 | 0.830 |
CDK7 |
0.870 | 0.844 | 1 | 0.803 |
P38B |
0.867 | 0.869 | 1 | 0.830 |
ERK1 |
0.867 | 0.858 | 1 | 0.840 |
CDK16 |
0.867 | 0.842 | 1 | 0.865 |
JNK2 |
0.867 | 0.887 | 1 | 0.846 |
KIS |
0.864 | 0.744 | 1 | 0.783 |
P38D |
0.864 | 0.867 | 1 | 0.877 |
DYRK2 |
0.863 | 0.782 | 1 | 0.751 |
CDK13 |
0.860 | 0.827 | 1 | 0.824 |
JNK3 |
0.859 | 0.874 | 1 | 0.823 |
CDK12 |
0.858 | 0.828 | 1 | 0.845 |
DYRK4 |
0.858 | 0.783 | 1 | 0.842 |
CDK3 |
0.857 | 0.735 | 1 | 0.872 |
CDK1 |
0.856 | 0.806 | 1 | 0.831 |
P38A |
0.855 | 0.843 | 1 | 0.758 |
CDK14 |
0.855 | 0.829 | 1 | 0.808 |
CDK9 |
0.855 | 0.819 | 1 | 0.816 |
HIPK4 |
0.854 | 0.544 | 1 | 0.536 |
DYRK1B |
0.852 | 0.756 | 1 | 0.803 |
CDK5 |
0.852 | 0.788 | 1 | 0.777 |
ERK2 |
0.851 | 0.842 | 1 | 0.790 |
HIPK1 |
0.849 | 0.717 | 1 | 0.729 |
DYRK1A |
0.847 | 0.656 | 1 | 0.711 |
CDK10 |
0.844 | 0.756 | 1 | 0.824 |
HIPK3 |
0.842 | 0.703 | 1 | 0.702 |
NLK |
0.841 | 0.746 | 1 | 0.541 |
CDK4 |
0.839 | 0.806 | 1 | 0.851 |
ERK5 |
0.837 | 0.446 | 1 | 0.476 |
JNK1 |
0.837 | 0.778 | 1 | 0.847 |
CLK3 |
0.836 | 0.470 | 1 | 0.514 |
CDK6 |
0.834 | 0.770 | 1 | 0.824 |
DYRK3 |
0.832 | 0.568 | 1 | 0.692 |
MAK |
0.829 | 0.560 | -2 | 0.827 |
SRPK1 |
0.826 | 0.334 | -3 | 0.766 |
ICK |
0.826 | 0.419 | -3 | 0.854 |
CDK2 |
0.824 | 0.599 | 1 | 0.711 |
CDKL5 |
0.824 | 0.221 | -3 | 0.814 |
MOK |
0.818 | 0.516 | 1 | 0.626 |
MTOR |
0.818 | 0.207 | 1 | 0.335 |
PRKD1 |
0.817 | 0.060 | -3 | 0.870 |
SRPK2 |
0.816 | 0.269 | -3 | 0.685 |
CLK1 |
0.816 | 0.400 | -3 | 0.735 |
PRP4 |
0.814 | 0.500 | -3 | 0.832 |
CDKL1 |
0.814 | 0.176 | -3 | 0.812 |
CLK4 |
0.812 | 0.363 | -3 | 0.759 |
TBK1 |
0.811 | -0.109 | 1 | 0.132 |
CDC7 |
0.810 | -0.083 | 1 | 0.163 |
CLK2 |
0.808 | 0.381 | -3 | 0.747 |
COT |
0.808 | -0.109 | 2 | 0.850 |
NDR2 |
0.807 | 0.005 | -3 | 0.859 |
IKKE |
0.805 | -0.132 | 1 | 0.132 |
PRKD2 |
0.805 | 0.034 | -3 | 0.787 |
PRPK |
0.805 | -0.081 | -1 | 0.879 |
MOS |
0.804 | -0.034 | 1 | 0.207 |
SRPK3 |
0.802 | 0.223 | -3 | 0.728 |
PIM3 |
0.800 | -0.032 | -3 | 0.847 |
CAMK1B |
0.800 | -0.019 | -3 | 0.851 |
ATR |
0.800 | -0.050 | 1 | 0.203 |
PDHK4 |
0.800 | -0.145 | 1 | 0.217 |
MARK4 |
0.799 | -0.022 | 4 | 0.882 |
P90RSK |
0.798 | 0.014 | -3 | 0.792 |
PKN3 |
0.798 | -0.039 | -3 | 0.838 |
PDHK1 |
0.798 | -0.139 | 1 | 0.196 |
CHAK2 |
0.798 | -0.040 | -1 | 0.894 |
MAPKAPK3 |
0.798 | -0.022 | -3 | 0.801 |
AMPKA1 |
0.797 | -0.022 | -3 | 0.858 |
NUAK2 |
0.797 | 0.013 | -3 | 0.832 |
TSSK1 |
0.797 | 0.009 | -3 | 0.882 |
GCN2 |
0.797 | -0.213 | 2 | 0.795 |
NEK6 |
0.796 | -0.081 | -2 | 0.840 |
SKMLCK |
0.796 | -0.041 | -2 | 0.854 |
ULK2 |
0.796 | -0.196 | 2 | 0.798 |
RAF1 |
0.795 | -0.206 | 1 | 0.150 |
NDR1 |
0.795 | -0.047 | -3 | 0.840 |
BMPR2 |
0.795 | -0.177 | -2 | 0.873 |
RSK2 |
0.795 | 0.001 | -3 | 0.780 |
AMPKA2 |
0.795 | -0.006 | -3 | 0.826 |
IKKB |
0.795 | -0.182 | -2 | 0.732 |
LATS2 |
0.795 | -0.024 | -5 | 0.762 |
WNK1 |
0.794 | -0.080 | -2 | 0.898 |
MAPKAPK2 |
0.794 | -0.003 | -3 | 0.748 |
ERK7 |
0.793 | 0.244 | 2 | 0.487 |
CAMLCK |
0.793 | -0.019 | -2 | 0.842 |
TSSK2 |
0.793 | -0.030 | -5 | 0.877 |
NIK |
0.792 | -0.074 | -3 | 0.872 |
PRKD3 |
0.792 | 0.016 | -3 | 0.750 |
DAPK2 |
0.791 | -0.035 | -3 | 0.869 |
MLK2 |
0.791 | -0.087 | 2 | 0.830 |
RSK3 |
0.791 | -0.023 | -3 | 0.776 |
RIPK3 |
0.790 | -0.135 | 3 | 0.775 |
MST4 |
0.790 | -0.071 | 2 | 0.822 |
BCKDK |
0.790 | -0.136 | -1 | 0.824 |
CAMK2D |
0.790 | -0.079 | -3 | 0.857 |
NIM1 |
0.789 | -0.069 | 3 | 0.796 |
WNK3 |
0.789 | -0.170 | 1 | 0.151 |
AURC |
0.789 | -0.001 | -2 | 0.652 |
NEK7 |
0.789 | -0.188 | -3 | 0.842 |
IKKA |
0.789 | -0.098 | -2 | 0.723 |
TGFBR2 |
0.789 | -0.107 | -2 | 0.751 |
HUNK |
0.789 | -0.147 | 2 | 0.811 |
PIM1 |
0.789 | 0.009 | -3 | 0.780 |
PKN2 |
0.788 | -0.081 | -3 | 0.835 |
NUAK1 |
0.788 | -0.016 | -3 | 0.782 |
QSK |
0.788 | -0.007 | 4 | 0.868 |
PKACG |
0.788 | -0.034 | -2 | 0.753 |
IRE1 |
0.788 | -0.092 | 1 | 0.153 |
MASTL |
0.788 | -0.151 | -2 | 0.829 |
CAMK2G |
0.787 | -0.128 | 2 | 0.772 |
PKCD |
0.787 | -0.048 | 2 | 0.772 |
ULK1 |
0.787 | -0.178 | -3 | 0.816 |
MELK |
0.787 | -0.049 | -3 | 0.815 |
DSTYK |
0.787 | -0.203 | 2 | 0.852 |
PHKG1 |
0.787 | -0.060 | -3 | 0.832 |
MPSK1 |
0.786 | 0.094 | 1 | 0.219 |
MNK2 |
0.786 | -0.036 | -2 | 0.793 |
MLK1 |
0.785 | -0.171 | 2 | 0.795 |
P70S6KB |
0.785 | -0.025 | -3 | 0.794 |
LATS1 |
0.785 | 0.024 | -3 | 0.873 |
DNAPK |
0.784 | -0.042 | 1 | 0.184 |
NEK9 |
0.784 | -0.181 | 2 | 0.830 |
GRK5 |
0.784 | -0.170 | -3 | 0.842 |
VRK2 |
0.783 | 0.081 | 1 | 0.255 |
PAK6 |
0.783 | -0.013 | -2 | 0.694 |
PAK3 |
0.783 | -0.079 | -2 | 0.776 |
GRK1 |
0.783 | -0.059 | -2 | 0.758 |
IRE2 |
0.783 | -0.079 | 2 | 0.747 |
ATM |
0.783 | -0.083 | 1 | 0.166 |
SMG1 |
0.783 | -0.059 | 1 | 0.186 |
BRSK2 |
0.783 | -0.060 | -3 | 0.820 |
RIPK1 |
0.782 | -0.186 | 1 | 0.140 |
MLK3 |
0.782 | -0.074 | 2 | 0.726 |
QIK |
0.782 | -0.078 | -3 | 0.837 |
CAMK4 |
0.781 | -0.107 | -3 | 0.812 |
CHK1 |
0.781 | -0.023 | -3 | 0.836 |
BRSK1 |
0.780 | -0.046 | -3 | 0.797 |
PAK1 |
0.780 | -0.065 | -2 | 0.776 |
PINK1 |
0.780 | 0.147 | 1 | 0.366 |
SIK |
0.780 | -0.034 | -3 | 0.760 |
ALK4 |
0.779 | -0.068 | -2 | 0.797 |
MSK2 |
0.779 | -0.050 | -3 | 0.763 |
MARK2 |
0.779 | -0.022 | 4 | 0.800 |
PKG2 |
0.779 | -0.011 | -2 | 0.686 |
ANKRD3 |
0.779 | -0.184 | 1 | 0.168 |
MARK3 |
0.779 | -0.018 | 4 | 0.835 |
SGK3 |
0.779 | -0.009 | -3 | 0.776 |
MNK1 |
0.778 | -0.036 | -2 | 0.796 |
PKCA |
0.778 | -0.045 | 2 | 0.711 |
TGFBR1 |
0.778 | -0.067 | -2 | 0.769 |
PKCB |
0.778 | -0.059 | 2 | 0.724 |
DLK |
0.777 | -0.229 | 1 | 0.166 |
RSK4 |
0.777 | -0.004 | -3 | 0.754 |
BMPR1B |
0.777 | -0.073 | 1 | 0.139 |
GSK3A |
0.777 | 0.186 | 4 | 0.422 |
NEK2 |
0.777 | -0.139 | 2 | 0.807 |
PKCZ |
0.777 | -0.070 | 2 | 0.772 |
CAMK2A |
0.777 | -0.032 | 2 | 0.743 |
AURB |
0.777 | -0.032 | -2 | 0.644 |
PKACB |
0.776 | -0.004 | -2 | 0.670 |
CHAK1 |
0.776 | -0.139 | 2 | 0.799 |
CAMK2B |
0.776 | -0.067 | 2 | 0.734 |
PKR |
0.775 | -0.114 | 1 | 0.172 |
GRK7 |
0.775 | -0.022 | 1 | 0.187 |
MSK1 |
0.775 | -0.034 | -3 | 0.766 |
PAK2 |
0.774 | -0.086 | -2 | 0.758 |
GRK6 |
0.774 | -0.168 | 1 | 0.154 |
DCAMKL1 |
0.774 | -0.042 | -3 | 0.786 |
PKCG |
0.774 | -0.073 | 2 | 0.714 |
AKT2 |
0.774 | 0.015 | -3 | 0.687 |
TTBK2 |
0.774 | -0.202 | 2 | 0.723 |
YSK4 |
0.774 | -0.177 | 1 | 0.136 |
SSTK |
0.774 | -0.019 | 4 | 0.863 |
TLK2 |
0.773 | -0.130 | 1 | 0.147 |
MAPKAPK5 |
0.773 | -0.076 | -3 | 0.742 |
PLK4 |
0.772 | -0.122 | 2 | 0.663 |
PIM2 |
0.772 | 0.006 | -3 | 0.748 |
MEK1 |
0.772 | -0.165 | 2 | 0.839 |
WNK4 |
0.771 | -0.098 | -2 | 0.900 |
PKCH |
0.770 | -0.089 | 2 | 0.708 |
MARK1 |
0.770 | -0.059 | 4 | 0.849 |
PLK1 |
0.770 | -0.161 | -2 | 0.761 |
IRAK4 |
0.770 | -0.108 | 1 | 0.132 |
CAMK1G |
0.770 | -0.054 | -3 | 0.754 |
SNRK |
0.770 | -0.146 | 2 | 0.717 |
MLK4 |
0.769 | -0.140 | 2 | 0.723 |
GRK4 |
0.768 | -0.207 | -2 | 0.779 |
MYLK4 |
0.768 | -0.062 | -2 | 0.751 |
PHKG2 |
0.768 | -0.084 | -3 | 0.782 |
BUB1 |
0.768 | 0.071 | -5 | 0.837 |
FAM20C |
0.768 | -0.056 | 2 | 0.552 |
PRKX |
0.768 | 0.013 | -3 | 0.678 |
MEKK1 |
0.767 | -0.148 | 1 | 0.162 |
DCAMKL2 |
0.766 | -0.057 | -3 | 0.799 |
MEK5 |
0.766 | -0.165 | 2 | 0.833 |
PKCT |
0.765 | -0.076 | 2 | 0.725 |
ACVR2A |
0.765 | -0.127 | -2 | 0.745 |
ZAK |
0.765 | -0.166 | 1 | 0.145 |
HRI |
0.765 | -0.170 | -2 | 0.828 |
NEK5 |
0.765 | -0.146 | 1 | 0.151 |
PAK5 |
0.765 | -0.050 | -2 | 0.636 |
AKT1 |
0.764 | -0.011 | -3 | 0.711 |
ALK2 |
0.764 | -0.111 | -2 | 0.774 |
DRAK1 |
0.764 | -0.162 | 1 | 0.124 |
ACVR2B |
0.764 | -0.134 | -2 | 0.753 |
SBK |
0.764 | 0.121 | -3 | 0.569 |
MST3 |
0.764 | -0.087 | 2 | 0.818 |
CAMK1D |
0.763 | -0.027 | -3 | 0.685 |
AURA |
0.763 | -0.059 | -2 | 0.597 |
MEKK2 |
0.763 | -0.140 | 2 | 0.811 |
PERK |
0.763 | -0.180 | -2 | 0.808 |
PKACA |
0.762 | -0.013 | -2 | 0.627 |
P70S6K |
0.762 | -0.039 | -3 | 0.714 |
PLK3 |
0.762 | -0.153 | 2 | 0.753 |
PASK |
0.761 | -0.044 | -3 | 0.865 |
PAK4 |
0.761 | -0.040 | -2 | 0.638 |
LKB1 |
0.761 | -0.053 | -3 | 0.864 |
PKN1 |
0.760 | -0.038 | -3 | 0.729 |
TAO3 |
0.760 | -0.089 | 1 | 0.184 |
GSK3B |
0.760 | 0.028 | 4 | 0.414 |
TLK1 |
0.760 | -0.160 | -2 | 0.782 |
SMMLCK |
0.760 | -0.054 | -3 | 0.816 |
PDK1 |
0.759 | -0.069 | 1 | 0.191 |
PKCI |
0.759 | -0.070 | 2 | 0.724 |
NEK11 |
0.758 | -0.150 | 1 | 0.178 |
PBK |
0.758 | -0.023 | 1 | 0.190 |
BMPR1A |
0.758 | -0.095 | 1 | 0.125 |
BRAF |
0.758 | -0.176 | -4 | 0.778 |
MAP3K15 |
0.757 | -0.093 | 1 | 0.158 |
GRK2 |
0.757 | -0.122 | -2 | 0.671 |
MEKK6 |
0.757 | -0.102 | 1 | 0.167 |
CAMK1A |
0.756 | -0.009 | -3 | 0.650 |
MEKK3 |
0.756 | -0.221 | 1 | 0.159 |
GAK |
0.755 | -0.064 | 1 | 0.205 |
TAO2 |
0.755 | -0.095 | 2 | 0.831 |
NEK4 |
0.754 | -0.153 | 1 | 0.137 |
CHK2 |
0.754 | -0.015 | -3 | 0.632 |
CK1E |
0.754 | -0.061 | -3 | 0.507 |
SGK1 |
0.754 | 0.028 | -3 | 0.617 |
CAMKK2 |
0.754 | -0.137 | -2 | 0.777 |
PKCE |
0.753 | -0.040 | 2 | 0.697 |
AKT3 |
0.753 | 0.002 | -3 | 0.637 |
TTBK1 |
0.752 | -0.172 | 2 | 0.639 |
HGK |
0.751 | -0.105 | 3 | 0.821 |
LOK |
0.751 | -0.090 | -2 | 0.802 |
DAPK3 |
0.751 | -0.056 | -3 | 0.795 |
GCK |
0.750 | -0.118 | 1 | 0.165 |
NEK8 |
0.750 | -0.202 | 2 | 0.810 |
LRRK2 |
0.750 | -0.055 | 2 | 0.830 |
AAK1 |
0.750 | 0.036 | 1 | 0.201 |
IRAK1 |
0.750 | -0.220 | -1 | 0.786 |
CAMKK1 |
0.750 | -0.212 | -2 | 0.767 |
HASPIN |
0.750 | 0.013 | -1 | 0.721 |
MRCKA |
0.750 | -0.025 | -3 | 0.749 |
TNIK |
0.750 | -0.085 | 3 | 0.816 |
BIKE |
0.749 | -0.006 | 1 | 0.194 |
NEK1 |
0.749 | -0.144 | 1 | 0.133 |
MRCKB |
0.749 | -0.019 | -3 | 0.735 |
KHS1 |
0.748 | -0.074 | 1 | 0.160 |
ROCK2 |
0.747 | -0.024 | -3 | 0.795 |
CK2A2 |
0.747 | -0.066 | 1 | 0.120 |
VRK1 |
0.747 | -0.143 | 2 | 0.829 |
MINK |
0.747 | -0.154 | 1 | 0.141 |
MST2 |
0.746 | -0.166 | 1 | 0.151 |
PKG1 |
0.746 | -0.029 | -2 | 0.608 |
NEK3 |
0.745 | -0.106 | 1 | 0.160 |
HPK1 |
0.745 | -0.124 | 1 | 0.166 |
CK1D |
0.745 | -0.044 | -3 | 0.459 |
CRIK |
0.743 | 0.016 | -3 | 0.717 |
DAPK1 |
0.743 | -0.064 | -3 | 0.778 |
YSK1 |
0.743 | -0.132 | 2 | 0.801 |
RIPK2 |
0.742 | -0.205 | 1 | 0.127 |
PDHK3_TYR |
0.742 | 0.158 | 4 | 0.891 |
SLK |
0.742 | -0.099 | -2 | 0.741 |
EEF2K |
0.741 | -0.136 | 3 | 0.764 |
KHS2 |
0.741 | -0.076 | 1 | 0.170 |
CK1G1 |
0.740 | -0.110 | -3 | 0.489 |
MST1 |
0.740 | -0.169 | 1 | 0.142 |
MEK2 |
0.740 | -0.194 | 2 | 0.829 |
TAK1 |
0.740 | -0.224 | 1 | 0.139 |
DMPK1 |
0.739 | 0.004 | -3 | 0.740 |
CK2A1 |
0.738 | -0.075 | 1 | 0.111 |
LIMK2_TYR |
0.738 | 0.144 | -3 | 0.905 |
CK1A2 |
0.737 | -0.072 | -3 | 0.455 |
GRK3 |
0.737 | -0.133 | -2 | 0.614 |
STK33 |
0.735 | -0.163 | 2 | 0.623 |
ASK1 |
0.734 | -0.116 | 1 | 0.156 |
ROCK1 |
0.734 | -0.037 | -3 | 0.752 |
TESK1_TYR |
0.733 | 0.032 | 3 | 0.877 |
PKMYT1_TYR |
0.733 | 0.110 | 3 | 0.859 |
TAO1 |
0.732 | -0.099 | 1 | 0.152 |
PDHK4_TYR |
0.730 | 0.039 | 2 | 0.871 |
MYO3B |
0.729 | -0.100 | 2 | 0.818 |
PLK2 |
0.729 | -0.125 | -3 | 0.728 |
MAP2K7_TYR |
0.729 | -0.065 | 2 | 0.858 |
MAP2K4_TYR |
0.729 | -0.015 | -1 | 0.895 |
TTK |
0.727 | -0.113 | -2 | 0.773 |
OSR1 |
0.726 | -0.130 | 2 | 0.803 |
RET |
0.726 | -0.093 | 1 | 0.180 |
MAP2K6_TYR |
0.725 | -0.020 | -1 | 0.903 |
JAK2 |
0.725 | -0.076 | 1 | 0.189 |
LIMK1_TYR |
0.724 | 0.003 | 2 | 0.852 |
MYO3A |
0.723 | -0.127 | 1 | 0.158 |
ROS1 |
0.723 | -0.078 | 3 | 0.802 |
MST1R |
0.722 | -0.074 | 3 | 0.829 |
TYK2 |
0.722 | -0.153 | 1 | 0.168 |
CSF1R |
0.722 | -0.064 | 3 | 0.825 |
NEK10_TYR |
0.721 | -0.077 | 1 | 0.151 |
PINK1_TYR |
0.721 | -0.163 | 1 | 0.211 |
PDHK1_TYR |
0.720 | -0.086 | -1 | 0.904 |
BMPR2_TYR |
0.720 | -0.043 | -1 | 0.872 |
TNK1 |
0.720 | -0.022 | 3 | 0.804 |
JAK1 |
0.718 | -0.059 | 1 | 0.157 |
TYRO3 |
0.718 | -0.126 | 3 | 0.816 |
JAK3 |
0.718 | -0.098 | 1 | 0.171 |
FGFR1 |
0.718 | -0.007 | 3 | 0.809 |
FGFR2 |
0.718 | -0.019 | 3 | 0.826 |
DDR1 |
0.717 | -0.095 | 4 | 0.850 |
TNNI3K_TYR |
0.717 | -0.030 | 1 | 0.200 |
STLK3 |
0.717 | -0.178 | 1 | 0.131 |
ALPHAK3 |
0.717 | -0.129 | -1 | 0.796 |
EPHB4 |
0.715 | -0.119 | -1 | 0.845 |
ABL2 |
0.714 | -0.097 | -1 | 0.827 |
EPHA6 |
0.713 | -0.117 | -1 | 0.855 |
TNK2 |
0.713 | -0.089 | 3 | 0.781 |
YANK3 |
0.712 | -0.083 | 2 | 0.405 |
TEK |
0.712 | -0.003 | 3 | 0.762 |
ABL1 |
0.712 | -0.103 | -1 | 0.819 |
KDR |
0.711 | -0.067 | 3 | 0.801 |
DDR2 |
0.711 | -0.005 | 3 | 0.768 |
YES1 |
0.711 | -0.103 | -1 | 0.857 |
FGR |
0.709 | -0.159 | 1 | 0.153 |
PDGFRB |
0.709 | -0.170 | 3 | 0.822 |
INSRR |
0.708 | -0.134 | 3 | 0.785 |
TXK |
0.708 | -0.106 | 1 | 0.137 |
FER |
0.707 | -0.184 | 1 | 0.161 |
AXL |
0.707 | -0.135 | 3 | 0.822 |
MERTK |
0.707 | -0.120 | 3 | 0.828 |
PDGFRA |
0.707 | -0.158 | 3 | 0.813 |
KIT |
0.706 | -0.130 | 3 | 0.816 |
HCK |
0.705 | -0.148 | -1 | 0.827 |
FLT3 |
0.704 | -0.169 | 3 | 0.809 |
EPHB1 |
0.704 | -0.166 | 1 | 0.144 |
ITK |
0.704 | -0.146 | -1 | 0.811 |
LCK |
0.703 | -0.116 | -1 | 0.824 |
FGFR3 |
0.703 | -0.061 | 3 | 0.800 |
ALK |
0.703 | -0.129 | 3 | 0.755 |
SRMS |
0.703 | -0.187 | 1 | 0.137 |
EPHA4 |
0.702 | -0.117 | 2 | 0.745 |
EPHB3 |
0.702 | -0.165 | -1 | 0.823 |
CK1A |
0.701 | -0.093 | -3 | 0.360 |
MET |
0.701 | -0.123 | 3 | 0.815 |
BLK |
0.700 | -0.105 | -1 | 0.823 |
LTK |
0.699 | -0.146 | 3 | 0.781 |
EPHB2 |
0.698 | -0.168 | -1 | 0.818 |
FLT4 |
0.698 | -0.131 | 3 | 0.792 |
EPHA1 |
0.696 | -0.143 | 3 | 0.799 |
NTRK1 |
0.696 | -0.198 | -1 | 0.847 |
BMX |
0.695 | -0.129 | -1 | 0.727 |
INSR |
0.695 | -0.148 | 3 | 0.753 |
NTRK3 |
0.695 | -0.140 | -1 | 0.798 |
NTRK2 |
0.695 | -0.191 | 3 | 0.792 |
WEE1_TYR |
0.695 | -0.112 | -1 | 0.770 |
TEC |
0.694 | -0.158 | -1 | 0.744 |
EPHA7 |
0.694 | -0.141 | 2 | 0.756 |
ERBB2 |
0.694 | -0.174 | 1 | 0.153 |
BTK |
0.693 | -0.217 | -1 | 0.784 |
FRK |
0.693 | -0.158 | -1 | 0.828 |
PTK2B |
0.693 | -0.115 | -1 | 0.781 |
FLT1 |
0.692 | -0.154 | -1 | 0.848 |
PTK6 |
0.692 | -0.198 | -1 | 0.759 |
FYN |
0.692 | -0.116 | -1 | 0.796 |
EGFR |
0.692 | -0.114 | 1 | 0.132 |
EPHA3 |
0.690 | -0.156 | 2 | 0.735 |
LYN |
0.686 | -0.161 | 3 | 0.738 |
MUSK |
0.686 | -0.135 | 1 | 0.122 |
MATK |
0.685 | -0.121 | -1 | 0.754 |
FGFR4 |
0.683 | -0.126 | -1 | 0.787 |
SRC |
0.683 | -0.148 | -1 | 0.797 |
EPHA5 |
0.683 | -0.167 | 2 | 0.739 |
EPHA8 |
0.682 | -0.151 | -1 | 0.793 |
CSK |
0.681 | -0.170 | 2 | 0.767 |
IGF1R |
0.678 | -0.147 | 3 | 0.697 |
YANK2 |
0.677 | -0.105 | 2 | 0.411 |
PTK2 |
0.676 | -0.097 | -1 | 0.787 |
ERBB4 |
0.675 | -0.113 | 1 | 0.135 |
EPHA2 |
0.675 | -0.149 | -1 | 0.771 |
CK1G3 |
0.673 | -0.104 | -3 | 0.310 |
SYK |
0.673 | -0.128 | -1 | 0.771 |
ZAP70 |
0.666 | -0.083 | -1 | 0.702 |
FES |
0.666 | -0.147 | -1 | 0.707 |
CK1G2 |
0.649 | -0.115 | -3 | 0.404 |