Motif 834 (n=171)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0JNW5 | BLTP3B | S891 | ochoa | Bridge-like lipid transfer protein family member 3B (Syntaxin-6 Habc-interacting protein of 164 kDa) (UHRF1-binding protein 1-like) | Tube-forming lipid transport protein which mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567). Required for retrograde traffic of vesicle clusters in the early endocytic pathway to the Golgi complex (PubMed:20163565, PubMed:35499567). {ECO:0000269|PubMed:20163565, ECO:0000269|PubMed:35499567}. |
| A2RU67 | FAM234B | S52 | ochoa | Protein FAM234B | None |
| A4UGR9 | XIRP2 | S3059 | ochoa | Xin actin-binding repeat-containing protein 2 (Beta-xin) (Cardiomyopathy-associated protein 3) (Xeplin) | Protects actin filaments from depolymerization (PubMed:15454575). Required for correct morphology of cell membranes and maturation of intercalated disks of cardiomyocytes via facilitating localization of XIRP1 and CDH2 to the termini of aligned mature cardiomyocytes (By similarity). Thereby required for correct postnatal heart development and growth regulation that is crucial for overall heart morphology and diastolic function (By similarity). Required for normal electrical conduction in the heart including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with the cardiac ion channel components Scn5a/Nav1.5 and Kcna5/Kv1.5 (By similarity). Required for regular actin filament spacing of the paracrystalline array in both inner and outer hair cells of the cochlea, thereby required for maintenance of stereocilia morphology (By similarity). {ECO:0000250|UniProtKB:Q4U4S6, ECO:0000269|PubMed:15454575}. |
| A6NKT7 | RGPD3 | S782 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| A8MW92 | PHF20L1 | S395 | ochoa | PHD finger protein 20-like protein 1 | Is a negative regulator of proteasomal degradation of a set of methylated proteins, including DNMT1 and SOX2 (PubMed:24492612, PubMed:29358331). Involved in the maintainance of embryonic stem cells pluripotency, through the regulation of SOX2 levels (By similarity). {ECO:0000250|UniProtKB:Q8CCJ9, ECO:0000269|PubMed:24492612, ECO:0000269|PubMed:29358331}. |
| K7ELQ4 | ATF7-NPFF | S304 | ochoa | ATF7-NPFF readthrough | None |
| O00170 | AIP | S159 | ochoa | AH receptor-interacting protein (AIP) (Aryl-hydrocarbon receptor-interacting protein) (HBV X-associated protein 2) (XAP-2) (Immunophilin homolog ARA9) | May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.; FUNCTION: Cellular negative regulator of the hepatitis B virus (HBV) X protein. |
| O00482 | NR5A2 | S243 | psp | Nuclear receptor subfamily 5 group A member 2 (Alpha-1-fetoprotein transcription factor) (B1-binding factor) (hB1F) (CYP7A promoter-binding factor) (Hepatocytic transcription factor) (Liver receptor homolog 1) (LRH-1) | Orphan nuclear receptor that binds DNA as a monomer to the 5'-TCAAGGCCA-3' sequence and controls expression of target genes: regulates key biological processes, such as early embryonic development, cholesterol and bile acid synthesis pathways, as well as liver and pancreas morphogenesis (PubMed:16289203, PubMed:18410128, PubMed:21614002, PubMed:32433991, PubMed:38409506, PubMed:9786908). Ligand-binding causes conformational change which causes recruitment of coactivators, promoting target gene activation (PubMed:21614002). The specific ligand is unknown, but specific phospholipids, such as phosphatidylethanolamine, phosphatidylserine, dilauroyl phosphatidylcholine and diundecanoyl phosphatidylcholine can act as ligand in vitro (PubMed:15707893, PubMed:15723037, PubMed:15897460, PubMed:21614002, PubMed:22504882, PubMed:23737522, PubMed:26416531, PubMed:26553876). Acts as a pioneer transcription factor, which unwraps target DNA from histones and elicits local opening of closed chromatin (PubMed:38409506). Plays a central role during preimplantation stages of embryonic development (By similarity). Plays a minor role in zygotic genome activation (ZGA) by regulating a small set of two-cell stage genes (By similarity). Plays a major role in morula development (2-16 cells embryos) by acting as a master regulator at the 8-cell stage, controlling expression of lineage-specifying transcription factors and genes involved in mitosis, telomere maintenance and DNA repair (By similarity). Zygotic NR5A2 binds to both closed and open chromatin with other transcription factors, often at SINE B1/Alu repeats DNA elements, promoting chromatin accessibility at nearby regulatory regions (By similarity). Also involved in the epiblast stage of development and embryonic stem cell pluripotency, by promoting expression of POU5F1/OCT4 (PubMed:27984042). Regulates other processes later in development, such as formation of connective tissue in lower jaw and middle ear, neural stem cell differentiation, ovarian follicle development and Sertoli cell differentiation (By similarity). Involved in exocrine pancreas development and acinar cell differentiation (By similarity). Acts as an essential transcriptional regulator of lipid metabolism (PubMed:20159957). Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver (PubMed:10359768). Also acts as a negative regulator of inflammation in different organs, such as, liver and pancreas (PubMed:20159957). Protects against intestinal inflammation via its ability to regulate glucocorticoid production (By similarity). Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (PubMed:20159957). Acts as a regulator of immunity by promoting lymphocyte T-cell development, proliferation and effector functions (By similarity). Also involved in resolution of endoplasmic reticulum stress in the liver (By similarity). {ECO:0000250|UniProtKB:P45448, ECO:0000269|PubMed:10359768, ECO:0000269|PubMed:15707893, ECO:0000269|PubMed:15723037, ECO:0000269|PubMed:15897460, ECO:0000269|PubMed:16289203, ECO:0000269|PubMed:18410128, ECO:0000269|PubMed:20159957, ECO:0000269|PubMed:21614002, ECO:0000269|PubMed:22504882, ECO:0000269|PubMed:23737522, ECO:0000269|PubMed:26416531, ECO:0000269|PubMed:26553876, ECO:0000269|PubMed:27984042, ECO:0000269|PubMed:32433991, ECO:0000269|PubMed:38409506, ECO:0000269|PubMed:9786908}.; FUNCTION: [Isoform 3]: In constrast to isoform 1 and isoform 2, does not induce cholesterol 7-alpha-hydroxylase gene (CYP7A) promoter activity. {ECO:0000269|PubMed:10359768}.; FUNCTION: (Microbial infection) Plays a crucial role for hepatitis B virus gene transcription and DNA replication. Mechanistically, synergistically cooperates with HNF1A to up-regulate the activity of one of the critical cis-elements in the hepatitis B virus genome enhancer II (ENII). {ECO:0000269|PubMed:14728801, ECO:0000269|PubMed:9786908}. |
| O00515 | LAD1 | S123 | ochoa | Ladinin-1 (Lad-1) (Linear IgA disease antigen) (LADA) | Anchoring filament protein which is a component of the basement membrane zone. {ECO:0000250}. |
| O14715 | RGPD8 | S781 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O14917 | PCDH17 | S1038 | ochoa | Protocadherin-17 (Protocadherin-68) | Potential calcium-dependent cell-adhesion protein. |
| O14994 | SYN3 | S455 | ochoa | Synapsin-3 (Synapsin III) | May be involved in the regulation of neurotransmitter release and synaptogenesis. |
| O15014 | ZNF609 | S900 | ochoa | Zinc finger protein 609 | Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others. {ECO:0000250|UniProtKB:Q8BZ47}.; FUNCTION: [Isoform 2]: Involved in the regulation of myoblast proliferation during myogenesis. {ECO:0000269|PubMed:28344082}. |
| O15056 | SYNJ2 | S1443 | ochoa | Synaptojanin-2 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 2) | Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis. |
| O15287 | FANCG | S383 | psp | Fanconi anemia group G protein (Protein FACG) (DNA repair protein XRCC9) | DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene. |
| O15405 | TOX3 | S529 | ochoa | TOX high mobility group box family member 3 (CAG trinucleotide repeat-containing gene F9 protein) (Trinucleotide repeat-containing gene 9 protein) | Transcriptional coactivator of the p300/CBP-mediated transcription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen-responsive C3 promoter region. {ECO:0000269|PubMed:21172805}. |
| O60285 | NUAK1 | S455 | ochoa | NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5) (ARK5) (Omphalocele kinase 1) | Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in DNA damage response: phosphorylates p53/TP53 at 'Ser-15' and 'Ser-392' and is recruited to the CDKN1A/WAF1 promoter to participate in transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with STK11, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (PubMed:25329316). {ECO:0000269|PubMed:12409306, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15060171, ECO:0000269|PubMed:15273717, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:20354225, ECO:0000269|PubMed:21317932, ECO:0000269|PubMed:25329316}. |
| O60291 | MGRN1 | S106 | ochoa | E3 ubiquitin-protein ligase MGRN1 (EC 2.3.2.27) (Mahogunin RING finger protein 1) (RING finger protein 156) (RING-type E3 ubiquitin transferase MGRN1) | E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling (By similarity). {ECO:0000250|UniProtKB:Q9D074, ECO:0000269|PubMed:17229889, ECO:0000269|PubMed:19703557, ECO:0000269|PubMed:19737927}. |
| O60291 | MGRN1 | S524 | ochoa | E3 ubiquitin-protein ligase MGRN1 (EC 2.3.2.27) (Mahogunin RING finger protein 1) (RING finger protein 156) (RING-type E3 ubiquitin transferase MGRN1) | E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling (By similarity). {ECO:0000250|UniProtKB:Q9D074, ECO:0000269|PubMed:17229889, ECO:0000269|PubMed:19703557, ECO:0000269|PubMed:19737927}. |
| O75376 | NCOR1 | S992 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O75376 | NCOR1 | S1472 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O75376 | NCOR1 | S2184 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O75794 | CDC123 | S299 | ochoa | Translation initiation factor eIF2 assembly protein (Cell division cycle protein 123 homolog) (Protein D123) (HT-1080) (PZ32) | ATP-dependent protein-folding chaperone for the eIF2 complex (PubMed:35031321, PubMed:37507029). Binds to the gamma subunit of the eIF2 complex which allows the subunit to assemble with the alpha and beta subunits (By similarity). {ECO:0000250|UniProtKB:Q05791, ECO:0000269|PubMed:35031321, ECO:0000269|PubMed:37507029}. |
| O94806 | PRKD3 | S391 | ochoa | Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (Protein kinase EPK2) (nPKC-nu) | Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity). {ECO:0000250}. |
| O94972 | TRIM37 | S454 | ochoa | E3 ubiquitin-protein ligase TRIM37 (EC 2.3.2.27) (Mulibrey nanism protein) (RING-type E3 ubiquitin transferase TRIM37) (Tripartite motif-containing protein 37) | E3 ubiquitin-protein ligase required to prevent centriole reduplication (PubMed:15885686, PubMed:23769972). Probably acts by ubiquitinating positive regulators of centriole reduplication (PubMed:23769972). Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042). Also acts as a positive regulator of peroxisome import by mediating monoubiquitination of PEX5 at 'Lys-472': monoubiquitination promotes PEX5 stabilitation by preventing its polyubiquitination and degradation by the proteasome (PubMed:28724525). Has anti-HIV activity (PubMed:24317724). {ECO:0000269|PubMed:15885686, ECO:0000269|PubMed:23769972, ECO:0000269|PubMed:24317724, ECO:0000269|PubMed:25470042, ECO:0000269|PubMed:28724525}. |
| O94992 | HEXIM1 | S98 | ochoa | Protein HEXIM1 (Cardiac lineage protein 1) (Estrogen down-regulated gene 1 protein) (Hexamethylene bis-acetamide-inducible protein 1) (Menage a quatre protein 1) | Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:14580347, PubMed:15201869, PubMed:15713661). Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:12832472, PubMed:14580347, PubMed:15201869, PubMed:15713661). May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity (PubMed:15940264, PubMed:15941832, PubMed:17088550). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000269|PubMed:12581153, ECO:0000269|PubMed:12832472, ECO:0000269|PubMed:14580347, ECO:0000269|PubMed:15201869, ECO:0000269|PubMed:15713661, ECO:0000269|PubMed:15940264, ECO:0000269|PubMed:15941832, ECO:0000269|PubMed:17088550, ECO:0000269|PubMed:28712728}. |
| O95359 | TACC2 | S1562 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| O95873 | C6orf47 | S131 | ochoa | Uncharacterized protein C6orf47 (Protein G4) | None |
| O95994 | AGR2 | S119 | ochoa | Anterior gradient protein 2 homolog (AG-2) (hAG-2) (HPC8) (Secreted cement gland protein XAG-2 homolog) | Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Promotes cell adhesion (PubMed:23274113). {ECO:0000250, ECO:0000269|PubMed:18199544, ECO:0000269|PubMed:23274113}. |
| P02042 | HBD | S51 | ochoa | Hemoglobin subunit delta (Delta-globin) (Hemoglobin delta chain) | Involved in oxygen transport from the lung to the various peripheral tissues. |
| P05408 | SCG5 | S108 | ochoa | Neuroendocrine protein 7B2 (Pituitary polypeptide) (Secretogranin V) (Secretogranin-5) (Secretory granule endocrine protein I) [Cleaved into: N-terminal peptide; C-terminal peptide] | Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro. {ECO:0000269|PubMed:7913882}. |
| P05496 | ATP5MC1 | S32 | ochoa | ATP synthase F(0) complex subunit C1, mitochondrial (ATP synthase lipid-binding protein) (ATP synthase membrane subunit c locus 1) (ATP synthase proteolipid P1) (ATP synthase proton-transporting mitochondrial F(0) complex subunit C1) (ATPase protein 9) (ATPase subunit c) (Proton-conducting channel, ATP synthase F(0) complex subunit c) | Subunit c, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (Probable). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). With the subunit a (MT-ATP6), forms the proton-conducting channel in the F(0) domain, that contains two crucial half-channels (inlet and outlet) that facilitate proton movement from the mitochondrial intermembrane space (IMS) into the matrix (PubMed:37244256). Protons are taken up via the inlet half-channel and released through the outlet half-channel, following a Grotthuss mechanism (PubMed:37244256). {ECO:0000269|PubMed:37244256, ECO:0000305|PubMed:37244256}. |
| P07949 | RET | Y1090 | psp | Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment] | Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation in response to glia cell line-derived growth family factors (GDNF, NRTN, ARTN, PSPN and GDF15) (PubMed:20064382, PubMed:20616503, PubMed:20702524, PubMed:21357690, PubMed:21454698, PubMed:24560924, PubMed:28846097, PubMed:28846099, PubMed:28953886, PubMed:31118272). In contrast to most receptor tyrosine kinases, RET requires not only its cognate ligands but also coreceptors, for activation (PubMed:21994944, PubMed:23333276, PubMed:28846097, PubMed:28846099, PubMed:28953886). GDNF ligands (GDNF, NRTN, ARTN, PSPN and GDF15) first bind their corresponding GDNFR coreceptors (GFRA1, GFRA2, GFRA3, GFRA4 and GFRAL, respectively), triggering RET autophosphorylation and activation, leading to activation of downstream signaling pathways, including the MAPK- and AKT-signaling pathways (PubMed:21994944, PubMed:23333276, PubMed:24560924, PubMed:25242331, PubMed:28846097, PubMed:28846099, PubMed:28953886). Acts as a dependence receptor via the GDNF-GFRA1 signaling: in the presence of the ligand GDNF in somatotrophs within pituitary, promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF (PubMed:20616503, PubMed:21994944). Required for the molecular mechanisms orchestration during intestine organogenesis via the ARTN-GFRA3 signaling: involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue (By similarity). Mediates, through interaction with GDF15-receptor GFRAL, GDF15-induced cell-signaling in the brainstem which triggers an aversive response, characterized by nausea, vomiting, and/or loss of appetite in response to various stresses (PubMed:28846097, PubMed:28846099, PubMed:28953886). Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner (PubMed:20702524, PubMed:21357690). Also active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage (PubMed:21357690). Triggers the differentiation of rapidly adapting (RA) mechanoreceptors (PubMed:20064382). Involved in the development of the neural crest (By similarity). Regulates nociceptor survival and size (By similarity). Phosphorylates PTK2/FAK1 (PubMed:21454698). {ECO:0000250|UniProtKB:P35546, ECO:0000269|PubMed:20064382, ECO:0000269|PubMed:20616503, ECO:0000269|PubMed:20702524, ECO:0000269|PubMed:21357690, ECO:0000269|PubMed:21454698, ECO:0000269|PubMed:21994944, ECO:0000269|PubMed:23333276, ECO:0000269|PubMed:24560924, ECO:0000269|PubMed:25242331, ECO:0000269|PubMed:28846097, ECO:0000269|PubMed:28846099, ECO:0000269|PubMed:28953886, ECO:0000269|PubMed:31118272}.; FUNCTION: [Isoform 1]: Isoform 1 in complex with GFRAL induces higher activation of MAPK-signaling pathway than isoform 2 in complex with GFRAL. {ECO:0000269|PubMed:28846099}. |
| P09884 | POLA1 | S209 | ochoa | DNA polymerase alpha catalytic subunit (EC 2.7.7.7) (DNA polymerase alpha catalytic subunit p180) | Catalytic subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, a regulatory subunit POLA2 and two primase subunits PRIM1 and PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively. The reason this transfer occurs is because the polymerase alpha has limited processivity and lacks intrinsic 3' exonuclease activity for proofreading error, and therefore is not well suited for replicating long complexes. In the cytosol, responsible for a substantial proportion of the physiological concentration of cytosolic RNA:DNA hybrids, which are necessary to prevent spontaneous activation of type I interferon responses (PubMed:27019227). {ECO:0000269|PubMed:26975377, ECO:0000269|PubMed:27019227, ECO:0000269|PubMed:31006512, ECO:0000269|PubMed:9518481}. |
| P0DJD0 | RGPD1 | S772 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | S780 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P13994 | YJU2B | S306 | ochoa | Probable splicing factor YJU2B (Coiled-coil domain-containing protein 130) | May be involved in mRNA splicing. {ECO:0000250|UniProtKB:Q9BW85}. |
| P20827 | EFNA1 | S154 | ochoa | Ephrin-A1 (EPH-related receptor tyrosine kinase ligand 1) (LERK-1) (Immediate early response protein B61) (Tumor necrosis factor alpha-induced protein 4) (TNF alpha-induced protein 4) [Cleaved into: Ephrin-A1, secreted form] | Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis. {ECO:0000269|PubMed:17332925, ECO:0000269|PubMed:18794797}. |
| P23258 | TUBG1 | S80 | ochoa|psp | Tubulin gamma-1 chain (Gamma-1-tubulin) (Gamma-tubulin complex component 1) (GCP-1) | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:38609661, PubMed:39321809). Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:38305685, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685, PubMed:38609661, PubMed:39321809). {ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| P23588 | EIF4B | S459 | ochoa | Eukaryotic translation initiation factor 4B (eIF-4B) | Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. |
| P24001 | IL32 | S133 | ochoa | Interleukin-32 (IL-32) (Natural killer cells protein 4) (Tumor necrosis factor alpha-inducing factor) | Cytokine that may play a role in innate and adaptive immune responses. It induces various cytokines such as TNFA/TNF-alpha and IL8. It activates typical cytokine signal pathways of NF-kappa-B and p38 MAPK. {ECO:0000269|PubMed:15664165}. |
| P25054 | APC | S2330 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P27816 | MAP4 | S179 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P27987 | ITPKB | S355 | ochoa | Inositol-trisphosphate 3-kinase B (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase B) (IP3 3-kinase B) (IP3K B) (InsP 3-kinase B) | Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis. {ECO:0000269|PubMed:11846419, ECO:0000269|PubMed:12747803, ECO:0000269|PubMed:1654894}. |
| P28360 | MSX1 | S136 | ochoa | Homeobox protein MSX-1 (Homeobox protein Hox-7) (Msh homeobox 1-like protein) | Acts as a transcriptional repressor (By similarity). Capable of transcription autoinactivation (By similarity). Binds to the consensus sequence 5'-C/GTAAT-3' in downstream activin regulatory elements (DARE) in the gene promoter, thereby repressing the transcription of CGA/alpha-GSU and GNRHR (By similarity). Represses transcription of myoblast differentiation factors (By similarity). Binds to core enhancer regions in target gene promoters of myoblast differentiation factors with binding specificity facilitated by interaction with PIAS1 (By similarity). Regulates, in a stage-specific manner, a developmental program of gene expression in the fetal tooth bud that controls odontoblast differentiation and proliferation of dental mesenchymal cells (By similarity). At the bud stage, required for mesenchymal molar tooth bud development via facilitating reciprocal signaling between dental epithelial and mesenchymal cells (By similarity). May also regulate expression of Wnt antagonists such as DKK2 and SFPR2 in the developing tooth mesenchyme (By similarity). Required for BMP4 expression in dental mesenchyme cells (By similarity). Also, in response to BMP4, required for BMP4 expression in neighboring dental epithelial cells (By similarity). Required for maximal FGF4-induced expression of SDC1 in dental mesenchyme cells (By similarity). Also in response to SDC1, required for SDC1 expression in neighboring dental epithelial cells (By similarity). At the early bell stage, acts to drive proliferation of dental mesenchyme cells, however during the late bell stage acts as an homeostatic regulator of the cell cycle (By similarity). Regulates proliferation and inhibits premature mesenchymal odontogenesis during the bell stage via inhibition of the Wnt signaling component CTNNB1 and subsequent repression of the odontoblast differentiation factors BMP2, BMP4, LEF1, ALPL and BGLAP/OCN (By similarity). Additionally, required for correct development and fusion of the palatal shelves and embryonic mandibular formation (By similarity). Plays a role in embryonic bone formation of the middle ear, skull and nasal bones (By similarity). Required for correct formation and thickness of the nail plate (By similarity). May play a role in limb-pattern formation (By similarity). {ECO:0000250|UniProtKB:P13297, ECO:0000269|PubMed:12807959, ECO:0000303|PubMed:8696335}. |
| P30307 | CDC25C | S122 | ochoa|psp | M-phase inducer phosphatase 3 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25C) | Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle (PubMed:8119945). When phosphorylated, highly effective in activating G2 cells into prophase (PubMed:8119945). Directly dephosphorylates CDK1 and activates its kinase activity (PubMed:8119945). {ECO:0000269|PubMed:8119945}. |
| P32322 | PYCR1 | S294 | ochoa | Pyrroline-5-carboxylate reductase 1, mitochondrial (P5C reductase 1) (P5CR 1) (EC 1.5.1.2) | Oxidoreductase that catalyzes the last step in proline biosynthesis, which corresponds to the reduction of pyrroline-5-carboxylate to L-proline using NAD(P)H (PubMed:16730026, PubMed:19648921, PubMed:23024808, PubMed:28258219). At physiologic concentrations, has higher specific activity in the presence of NADH (PubMed:16730026, PubMed:23024808). Involved in the cellular response to oxidative stress (PubMed:16730026, PubMed:19648921). {ECO:0000269|PubMed:16730026, ECO:0000269|PubMed:19648921, ECO:0000269|PubMed:23024808, ECO:0000269|PubMed:28258219}. |
| P41182 | BCL6 | S404 | ochoa | B-cell lymphoma 6 protein (BCL-6) (B-cell lymphoma 5 protein) (BCL-5) (Protein LAZ-3) (Zinc finger and BTB domain-containing protein 27) (Zinc finger protein 51) | Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation. {ECO:0000269|PubMed:10981963, ECO:0000269|PubMed:12402037, ECO:0000269|PubMed:12414651, ECO:0000269|PubMed:12504096, ECO:0000269|PubMed:15454082, ECO:0000269|PubMed:15577913, ECO:0000269|PubMed:16142238, ECO:0000269|PubMed:17828269, ECO:0000269|PubMed:18212045, ECO:0000269|PubMed:18280243, ECO:0000269|PubMed:22113614, ECO:0000269|PubMed:23166356, ECO:0000269|PubMed:23911289, ECO:0000269|PubMed:9649500}. |
| P46060 | RANGAP1 | S428 | ochoa|psp | Ran GTPase-activating protein 1 (RanGAP1) | GTPase activator for RAN (PubMed:16428860, PubMed:8146159, PubMed:8896452). Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export (PubMed:27160050, PubMed:8896452). Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export (PubMed:27160050). {ECO:0000269|PubMed:16428860, ECO:0000269|PubMed:27160050, ECO:0000269|PubMed:8146159, ECO:0000269|PubMed:8896452}. |
| P46939 | UTRN | S3297 | ochoa | Utrophin (Dystrophin-related protein 1) (DRP-1) | May play a role in anchoring the cytoskeleton to the plasma membrane. {ECO:0000250}. |
| P49792 | RANBP2 | S781 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P49815 | TSC2 | S1155 | ochoa|psp | Tuberin (Tuberous sclerosis 2 protein) | Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:33436626, PubMed:35772404). Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12172553, PubMed:12820960, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:33436626). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:35772404). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity). {ECO:0000250|UniProtKB:P49816, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12820960, ECO:0000269|PubMed:12842888, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:22819219, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:33436626, ECO:0000269|PubMed:35772404}. |
| P50548 | ERF | S327 | ochoa | ETS domain-containing transcription factor ERF (Ets2 repressor factor) (PE-2) | Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment (By similarity). May be important for regulating trophoblast stem cell differentiation (By similarity). {ECO:0000250}. |
| P52701 | MSH6 | S830 | ochoa|psp | DNA mismatch repair protein Msh6 (hMSH6) (G/T mismatch-binding protein) (GTBP) (GTMBP) (MutS protein homolog 6) (MutS-alpha 160 kDa subunit) (p160) | Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction. {ECO:0000269|PubMed:10078208, ECO:0000269|PubMed:10660545, ECO:0000269|PubMed:15064730, ECO:0000269|PubMed:21120944, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:9564049, ECO:0000269|PubMed:9822679, ECO:0000269|PubMed:9822680}. |
| P57682 | KLF3 | S71 | ochoa|psp | Krueppel-like factor 3 (Basic krueppel-like factor) (CACCC-box-binding protein BKLF) (TEF-2) | Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis (By similarity). {ECO:0000250}. |
| P57721 | PCBP3 | S201 | ochoa | Poly(rC)-binding protein 3 (Alpha-CP3) (PCBP3-overlapping transcript) (PCBP3-overlapping transcript 1) | Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. {ECO:0000250}. |
| P61586 | RHOA | S88 | psp | Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12) | Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such as cytoskeletal dynamics, cell migration and cell cycle (PubMed:23871831). Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers (PubMed:31570889, PubMed:8910519, PubMed:9121475). Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis (PubMed:12900402, PubMed:16236794). Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion (PubMed:20974804, PubMed:23940119). Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly (PubMed:19934221). The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (PubMed:20937854). Regulates KCNA2 potassium channel activity by reducing its location at the cell surface in response to CHRM1 activation; promotes KCNA2 endocytosis (PubMed:19403695, PubMed:9635436). Acts as an allosteric activator of guanine nucleotide exchange factor ECT2 by binding in its activated GTP-bound form to the PH domain of ECT2 which stimulates the release of PH inhibition and promotes the binding of substrate RHOA to the ECT2 catalytic center (PubMed:31888991). May be an activator of PLCE1 (PubMed:16103226). In neurons, involved in the inhibition of the initial spine growth. Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling (By similarity). Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (By similarity). When activated by DAAM1 may signal centrosome maturation and chromosomal segregation during cell division. May also be involved in contractile ring formation during cytokinesis. {ECO:0000250|UniProtKB:P61589, ECO:0000250|UniProtKB:Q9QUI0, ECO:0000269|PubMed:12900402, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:19403695, ECO:0000269|PubMed:19934221, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:20974804, ECO:0000269|PubMed:23871831, ECO:0000269|PubMed:23940119, ECO:0000269|PubMed:31570889, ECO:0000269|PubMed:31888991, ECO:0000269|PubMed:8910519, ECO:0000269|PubMed:9121475, ECO:0000269|PubMed:9635436}.; FUNCTION: (Microbial infection) Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague. {ECO:0000269|PubMed:12062101, ECO:0000269|PubMed:12538863}. |
| P78415 | IRX3 | S365 | ochoa | Iroquois-class homeodomain protein IRX-3 (Homeodomain protein IRXB1) (Iroquois homeobox protein 3) | Transcription factor involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells. Acts as a regulator of energy metabolism. {ECO:0000250|UniProtKB:P81067}. |
| P78524 | DENND2B | S539 | ochoa | DENN domain-containing protein 2B (HeLa tumor suppression 1) (Suppression of tumorigenicity 5 protein) | [Isoform 1]: May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane (PubMed:29030480). {ECO:0000269|PubMed:29030480, ECO:0000269|PubMed:9632734}.; FUNCTION: [Isoform 2]: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}.; FUNCTION: [Isoform 3]: May block ERK2 activation stimulated by ABL1 (Probable). May alter cell morphology and cell growth (Probable). {ECO:0000305|PubMed:10229203, ECO:0000305|PubMed:9632734}. |
| Q01167 | FOXK2 | S398 | ochoa|psp | Forkhead box protein K2 (G/T-mismatch specific binding protein) (nGTBP) (Interleukin enhancer-binding factor 1) | Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:22083952, PubMed:25451922). Together with FOXK1, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Together with FOXK1, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). In addition to the 5'-GTAAACA-3' DNA motif, also binds the 5'-TGANTCA-3' palindromic DNA motif, and co-associates with JUN/AP-1 to activate transcription (PubMed:22083952). Also able to bind to a minimal DNA heteroduplex containing a G/T-mismatch with 5'-TRT[G/T]NB-3' sequence (PubMed:20097901). Binds to NFAT-like motifs (purine-rich) in the IL2 promoter (PubMed:1339390). Positively regulates WNT/beta-catenin signaling by translocating DVL proteins into the nucleus (PubMed:25805136). Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important viral and cellular promoter elements (PubMed:1909027). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK2-bound genes (PubMed:24634419, PubMed:30664650). {ECO:0000250|UniProtKB:Q3UCQ1, ECO:0000269|PubMed:1339390, ECO:0000269|PubMed:1909027, ECO:0000269|PubMed:20097901, ECO:0000269|PubMed:22083952, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:25451922, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:30664650}. |
| Q02156 | PRKCE | S381 | ochoa | Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon) | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration. In HeLa cells, contributes to hepatocyte growth factor (HGF)-induced cell migration, and in human corneal epithelial cells, plays a critical role in wound healing after activation by HGF. During cytokinesis, forms a complex with YWHAB, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implicate the regulation of RHOA. In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F-actin via interaction with COPB1. During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length. Plays a role in the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3). Involved in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement. May be involved in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation. Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol. Upon PMA treatment, phosphorylates the capsaicin- and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons. Is able to form a complex with PDLIM5 and N-type calcium channel, and may enhance channel activities and potentiates fast synaptic transmission by phosphorylating the pore-forming alpha subunit CACNA1B (CaV2.2). In prostate cancer cells, interacts with and phosphorylates STAT3, which increases DNA-binding and transcriptional activity of STAT3 and seems to be essential for prostate cancer cell invasion. Downstream of TLR4, plays an important role in the lipopolysaccharide (LPS)-induced immune response by phosphorylating and activating TICAM2/TRAM, which in turn activates the transcription factor IRF3 and subsequent cytokines production. In differentiating erythroid progenitors, is regulated by EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2. May be involved in the regulation of the insulin-induced phosphorylation and activation of AKT1. Phosphorylates NLRP5/MATER and may thereby modulate AKT pathway activation in cumulus cells (PubMed:19542546). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000269|PubMed:11884385, ECO:0000269|PubMed:1374067, ECO:0000269|PubMed:15355962, ECO:0000269|PubMed:16757566, ECO:0000269|PubMed:17603037, ECO:0000269|PubMed:17875639, ECO:0000269|PubMed:17875724, ECO:0000269|PubMed:19542546, ECO:0000269|PubMed:21806543, ECO:0000269|PubMed:36040231}. |
| Q04725 | TLE2 | S307 | ochoa | Transducin-like enhancer protein 2 (Enhancer of split groucho-like protein 2) (ESG2) | Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). {ECO:0000250}. |
| Q06413 | MEF2C | S183 | ochoa | Myocyte-specific enhancer factor 2C (Myocyte enhancer factor 2C) | Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoforms that lack the repressor domain are more active than isoform 1. {ECO:0000250|UniProtKB:Q8CFN5, ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:15340086, ECO:0000269|PubMed:15831463, ECO:0000269|PubMed:15834131, ECO:0000269|PubMed:9069290, ECO:0000269|PubMed:9384584}. |
| Q08AE8 | SPIRE1 | S735 | ochoa | Protein spire homolog 1 (Spir-1) | Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed:11747823, PubMed:21620703). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (PubMed:11747823). Required for asymmetric spindle positioning and asymmetric cell division during meiosis (PubMed:21620703). Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703). Also acts in the nucleus: together with FMN2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). In addition, promotes innate immune signaling downstream of dsRNA sensing (PubMed:35148361). Mechanistically, contributes to IRF3 phosphorylation and activation downstream of MAVS and upstream of TBK1 (PubMed:35148361). {ECO:0000269|PubMed:11747823, ECO:0000269|PubMed:21620703, ECO:0000269|PubMed:26287480, ECO:0000269|PubMed:35148361}. |
| Q12830 | BPTF | S2471 | ochoa | Nucleosome-remodeling factor subunit BPTF (Bromodomain and PHD finger-containing transcription factor) (Fetal Alz-50 clone 1 protein) (Fetal Alzheimer antigen) | Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:28801535). The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes (PubMed:16728976, PubMed:16728978). Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent (PubMed:16728976, PubMed:16728978, PubMed:18042461). May also regulate transcription through direct binding to DNA or transcription factors (PubMed:10575013). {ECO:0000269|PubMed:10575013, ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:16728976, ECO:0000269|PubMed:16728978, ECO:0000269|PubMed:18042461, ECO:0000269|PubMed:28801535}. |
| Q13459 | MYO9B | S1115 | ochoa | Unconventional myosin-IXb (Unconventional myosin-9b) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:26529257, PubMed:9490638). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). {ECO:0000269|PubMed:26529257, ECO:0000269|PubMed:9490638}. |
| Q13469 | NFATC2 | S148 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1) | Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF (PubMed:15790681). Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway (PubMed:21871017). Is involved in the negative regulation of chondrogenesis (PubMed:35789258). Recruited by AKAP5 to ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where store-operated Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses. {ECO:0000250|UniProtKB:Q60591, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:21871017, ECO:0000269|PubMed:35789258}. |
| Q13625 | TP53BP2 | S576 | ochoa | Apoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2) | Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53 (PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of NAE1 to conjugate NEDD8 to CUL1, and thereby decreases NAE1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. {ECO:0000269|PubMed:11684014, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:12694406, ECO:0000269|PubMed:19377511}. |
| Q13950 | RUNX2 | S28 | ochoa|psp | Runt-related transcription factor 2 (Acute myeloid leukemia 3 protein) (Core-binding factor subunit alpha-1) (CBF-alpha-1) (Oncogene AML-3) (Osteoblast-specific transcription factor 2) (OSF-2) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEA2-alpha A) (PEBP2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit) | Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis (PubMed:28505335, PubMed:28703881, PubMed:28738062). Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation. {ECO:0000250, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:28505335, ECO:0000269|PubMed:28703881, ECO:0000269|PubMed:28738062}. |
| Q14160 | SCRIB | S446 | ochoa | Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) | Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}. |
| Q15596 | NCOA2 | S565 | ochoa|psp | Nuclear receptor coactivator 2 (NCoA-2) (Class E basic helix-loop-helix protein 75) (bHLHe75) (Transcriptional intermediary factor 2) (hTIF2) | Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:23508108, PubMed:8670870, PubMed:9430642, PubMed:22504882, PubMed:26553876). Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) (PubMed:23508108, PubMed:8670870, PubMed:9430642). Required with NCOA1 to control energy balance between white and brown adipose tissues (PubMed:23508108, PubMed:8670870, PubMed:9430642). Critical regulator of glucose metabolism regulation, acts as a RORA coactivator to specifically modulate G6PC1 expression (PubMed:23508108, PubMed:8670870, PubMed:9430642). Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3 (PubMed:23508108). Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-BMAL1 heterodimer (By similarity). {ECO:0000250|UniProtKB:Q61026, ECO:0000269|PubMed:22504882, ECO:0000269|PubMed:23508108, ECO:0000269|PubMed:26553876, ECO:0000269|PubMed:8670870, ECO:0000269|PubMed:9430642}. |
| Q15596 | NCOA2 | S716 | ochoa | Nuclear receptor coactivator 2 (NCoA-2) (Class E basic helix-loop-helix protein 75) (bHLHe75) (Transcriptional intermediary factor 2) (hTIF2) | Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:23508108, PubMed:8670870, PubMed:9430642, PubMed:22504882, PubMed:26553876). Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) (PubMed:23508108, PubMed:8670870, PubMed:9430642). Required with NCOA1 to control energy balance between white and brown adipose tissues (PubMed:23508108, PubMed:8670870, PubMed:9430642). Critical regulator of glucose metabolism regulation, acts as a RORA coactivator to specifically modulate G6PC1 expression (PubMed:23508108, PubMed:8670870, PubMed:9430642). Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3 (PubMed:23508108). Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-BMAL1 heterodimer (By similarity). {ECO:0000250|UniProtKB:Q61026, ECO:0000269|PubMed:22504882, ECO:0000269|PubMed:23508108, ECO:0000269|PubMed:26553876, ECO:0000269|PubMed:8670870, ECO:0000269|PubMed:9430642}. |
| Q155Q3 | DIXDC1 | S261 | ochoa | Dixin (Coiled-coil protein DIX1) (Coiled-coil-DIX1) (DIX domain-containing protein 1) | Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2. {ECO:0000269|PubMed:15262978, ECO:0000269|PubMed:21189423}. |
| Q15742 | NAB2 | S479 | ochoa | NGFI-A-binding protein 2 (EGR-1-binding protein 2) (Melanoma-associated delayed early response protein) (Protein MADER) | Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity). {ECO:0000250}. |
| Q15911 | ZFHX3 | S2207 | ochoa | Zinc finger homeobox protein 3 (AT motif-binding factor 1) (AT-binding transcription factor 1) (Alpha-fetoprotein enhancer-binding protein) (Zinc finger homeodomain protein 3) (ZFH-3) | Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3 (PubMed:25105025). Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain (By similarity). Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression (PubMed:11312261). Down-regulates the MUC5AC promoter in gastric cancer (PubMed:17330845). In association with RUNX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). Inhibits estrogen receptor (ESR1) function by selectively competing with coactivator NCOA3 for binding to ESR1 in ESR1-positive breast cancer cells (PubMed:20720010). {ECO:0000250|UniProtKB:Q61329, ECO:0000269|PubMed:11312261, ECO:0000269|PubMed:17330845, ECO:0000269|PubMed:20599712, ECO:0000269|PubMed:20720010, ECO:0000269|PubMed:25105025}. |
| Q16799 | RTN1 | S480 | ochoa | Reticulon-1 (Neuroendocrine-specific protein) | Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity. {ECO:0000269|PubMed:15286784}. |
| Q2LD37 | BLTP1 | S704 | ochoa | Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein) | Tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (Probable). Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as a regulator of phagocytosis (PubMed:31540829). {ECO:0000269|PubMed:30906834, ECO:0000269|PubMed:31540829, ECO:0000305|PubMed:35015055, ECO:0000305|PubMed:35491307}. |
| Q3T8J9 | GON4L | S775 | ochoa | GON-4-like protein (GON-4 homolog) | Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A and HDAC1. Required for B cell lymphopoiesis. {ECO:0000250|UniProtKB:Q9DB00}. |
| Q49AM3 | TTC31 | S464 | ochoa | Tetratricopeptide repeat protein 31 (TPR repeat protein 31) | None |
| Q4FZB7 | KMT5B | S635 | ochoa | Histone-lysine N-methyltransferase KMT5B (Lysine N-methyltransferase 5B) (Lysine-specific methyltransferase 5B) (Suppressor of variegation 4-20 homolog 1) (Su(var)4-20 homolog 1) (Suv4-20h1) ([histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B) (EC 2.1.1.362) ([histone H4]-lysine20 N-methyltransferase KMT5B) (EC 2.1.1.361) | Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity (PubMed:24396869, PubMed:28114273). In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (PubMed:24396869). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Plays a role in myogenesis by regulating the expression of target genes, such as EID3 (PubMed:23720823). Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (PubMed:28114273). May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity). {ECO:0000250|UniProtKB:Q3U8K7, ECO:0000269|PubMed:23720823, ECO:0000269|PubMed:24396869, ECO:0000269|PubMed:28114273}. |
| Q53ET0 | CRTC2 | S131 | ochoa | CREB-regulated transcription coactivator 2 (Transducer of regulated cAMP response element-binding protein 2) (TORC-2) (Transducer of CREB protein 2) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:14536081, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:16809310, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223}. |
| Q5T0Z8 | C6orf132 | S736 | ochoa | Uncharacterized protein C6orf132 | None |
| Q5THK1 | PRR14L | S582 | ochoa | Protein PRR14L (Proline rich 14-like protein) | None |
| Q5VZK9 | CARMIL1 | S1094 | ochoa | F-actin-uncapping protein LRRC16A (CARMIL homolog) (Capping protein regulator and myosin 1 linker protein 1) (Capping protein, Arp2/3 and myosin-I linker homolog 1) (Capping protein, Arp2/3 and myosin-I linker protein 1) (Leucine-rich repeat-containing protein 16A) | Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments (PubMed:16054028). Plays a role in lamellipodial protrusion formations and cell migration (PubMed:19846667). {ECO:0000269|PubMed:16054028, ECO:0000269|PubMed:19846667}. |
| Q68DA7 | FMN1 | S518 | ochoa | Formin-1 (Limb deformity protein homolog) | Plays a role in the formation of adherens junction and the polymerization of linear actin cables. {ECO:0000250}. |
| Q68DQ2 | CRYBG3 | S629 | ochoa | Very large A-kinase anchor protein (vlAKAP) (Beta/gamma crystallin domain-containing protein 3) | [Isoform vlAKAP]: Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA). {ECO:0000269|PubMed:25097019}. |
| Q68EM7 | ARHGAP17 | S520 | ochoa | Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1) | Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. {ECO:0000269|PubMed:11431473, ECO:0000269|PubMed:16678097}. |
| Q6NSJ2 | PHLDB3 | S254 | ochoa | Pleckstrin homology-like domain family B member 3 | None |
| Q6P9H4 | CNKSR3 | S479 | ochoa | Connector enhancer of kinase suppressor of ras 3 (Connector enhancer of KSR 3) (CNK homolog protein 3) (CNK3) (CNKSR family member 3) (Maguin-like protein) | Involved in transepithelial sodium transport. Regulates aldosterone-induced and epithelial sodium channel (ENaC)-mediated sodium transport through regulation of ENaC cell surface expression. Acts as a scaffold protein coordinating the assembly of an ENaC-regulatory complex (ERC). {ECO:0000269|PubMed:22851176}. |
| Q6UB98 | ANKRD12 | S149 | ochoa | Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein) | May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation. |
| Q6UWD8 | C16orf54 | S184 | ochoa | Transmembrane protein C16orf54 | None |
| Q6UWF3 | SCIMP | S76 | ochoa | SLP adapter and CSK-interacting membrane protein (SLP65/SLP76, Csk-interacting membrane protein) | Lipid tetraspanin-associated transmembrane adapter/mediator that acts as a scaffold for Src-family kinases and other signaling proteins in immune cells (PubMed:21930792). It is involved in major histocompatibility complex class II (MHC-II) signaling transduction in B cells, where it is required in generating the calcium response and enhancing ERK activity upon MHC-II stimulation (PubMed:21930792). In dendritic cells, it is involved in sustaining CLEC7A/DECTIN1 signaling after CLEC7A activation by fungal beta-glucans (By similarity). It also acts as an agonist-inducible signaling adapter for TLR1, TLR2, TLR3, TLR4, and TLR7 by selectively enabling the expression of pro-inflammatory cytokines IL6 and IL12B in macrophages and acting as a scaffold for phosphorylation of Toll-like receptors by Src-family kinases (By similarity). {ECO:0000250|UniProtKB:Q3UU41, ECO:0000269|PubMed:21930792}. |
| Q6VMQ6 | ATF7IP | S113 | ochoa | Activating transcription factor 7-interacting protein 1 (ATF-interacting protein) (ATF-IP) (ATF7-interacting protein) (ATFa-associated modulator) (hAM) (MBD1-containing chromatin-associated factor 1) (P621) | Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing (PubMed:27732843). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1 (PubMed:12665582). Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (PubMed:14536086, PubMed:27732843). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells (PubMed:19106100). {ECO:0000269|PubMed:12665582, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:19106100, ECO:0000269|PubMed:27732843}. |
| Q6W2J9 | BCOR | S367 | ochoa | BCL-6 corepressor (BCoR) | Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2). {ECO:0000269|PubMed:10898795, ECO:0000269|PubMed:15004558, ECO:0000269|PubMed:18280243, ECO:0000269|PubMed:19578371, ECO:0000269|PubMed:23911289}. |
| Q711Q0 | CEFIP | S470 | ochoa | Cardiac-enriched FHL2-interacting protein | Plays an important role in cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. {ECO:0000250|UniProtKB:M0RD54}. |
| Q7Z2Z2 | EFL1 | S948 | ochoa | Elongation factor-like GTPase 1 (EC 3.6.5.-) (Elongation factor Tu GTP-binding domain-containing protein 1) (Elongation factor-like 1) (Protein FAM42A) | GTPase involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. {ECO:0000269|PubMed:21536732}. |
| Q7Z3J3 | RGPD4 | S782 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z589 | EMSY | S385 | ochoa | BRCA2-interacting transcriptional repressor EMSY | Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin (PubMed:14651845). Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2 (PubMed:14651845). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). {ECO:0000269|PubMed:14651845, ECO:0000269|PubMed:19131338}. |
| Q86T24 | ZBTB33 | S237 | ochoa | Transcriptional regulator Kaiso (Zinc finger and BTB domain-containing protein 33) | Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2. Represses expression of MMP7 in conjunction with transcriptional corepressors CBFA2T3, CBFA2T2 and RUNX1T1 (PubMed:23251453). {ECO:0000269|PubMed:11445535, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:15548582, ECO:0000269|PubMed:15817151, ECO:0000269|PubMed:16354688, ECO:0000269|PubMed:23251453}. |
| Q86T90 | KIAA1328 | S273 | ochoa | Protein hinderin | Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes. {ECO:0000269|PubMed:15656913}. |
| Q86TC9 | MYPN | S101 | ochoa | Myopalladin (145 kDa sarcomeric protein) | Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines. {ECO:0000269|PubMed:11309420}. |
| Q86U70 | LDB1 | S381 | ochoa | LIM domain-binding protein 1 (LDB-1) (Carboxyl-terminal LIM domain-binding protein 2) (CLIM-2) (LIM domain-binding factor CLIM2) (hLdb1) (Nuclear LIM interactor) | Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state. {ECO:0000250|UniProtKB:P70662}. |
| Q86US8 | SMG6 | S424 | ochoa | Telomerase-binding protein EST1A (EC 3.1.-.-) (Ever shorter telomeres 1A) (hEST1A) (Nonsense mediated mRNA decay factor SMG6) (Smg-6 homolog) (hSmg5/7a) | Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini (PubMed:19179534). May have a general role in telomere regulation (PubMed:12676087, PubMed:12699629). Promotes in vitro the ability of TERT to elongate telomeres (PubMed:12676087, PubMed:12699629). Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization (PubMed:12676087, PubMed:12699629). Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER) (PubMed:12676087, PubMed:12699629). {ECO:0000269|PubMed:12676087, ECO:0000269|PubMed:12699629, ECO:0000269|PubMed:19179534}.; FUNCTION: Plays a role in nonsense-mediated mRNA decay (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). Is thought to provide a link to the mRNA degradation machinery as it has endonuclease activity required to initiate NMD, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). Degrades single-stranded RNA (ssRNA), but not ssDNA or dsRNA (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). {ECO:0000269|PubMed:17053788, ECO:0000269|PubMed:18974281, ECO:0000269|PubMed:19060897, ECO:0000269|PubMed:20930030}. |
| Q86UU1 | PHLDB1 | S470 | ochoa | Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha) | None |
| Q86YN6 | PPARGC1B | S524 | ochoa | Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PGC-1-beta) (PPAR-gamma coactivator 1-beta) (PPARGC-1-beta) (PGC-1-related estrogen receptor alpha coactivator) | Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. {ECO:0000269|PubMed:11854298, ECO:0000269|PubMed:12678921, ECO:0000269|PubMed:15546003, ECO:0000269|PubMed:23836911}. |
| Q8IVG5 | SAMD9L | S79 | ochoa | Sterile alpha motif domain-containing protein 9-like (SAM domain-containing protein 9-like) | May be involved in endosome fusion. Mediates down-regulation of growth factor signaling via internalization of growth factor receptors. {ECO:0000250|UniProtKB:Q69Z37}. |
| Q8IW40 | DNAAF19 | S91 | ochoa | Dynein axonemal assembly factor 19 (Coiled-coil domain-containing protein 103) | Dynein-attachment factor required for cilia motility. {ECO:0000269|PubMed:22581229}. |
| Q8IXF0 | NPAS3 | S639 | ochoa | Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Basic-helix-loop-helix-PAS protein MOP6) (Class E basic helix-loop-helix protein 12) (bHLHe12) (Member of PAS protein 6) (PAS domain-containing protein 6) | May play a broad role in neurogenesis. May control regulatory pathways relevant to schizophrenia and to psychotic illness (By similarity). {ECO:0000250}. |
| Q8IYT8 | ULK2 | S509 | ochoa | Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) | Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons. {ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21460635, ECO:0000269|PubMed:21690395, ECO:0000269|PubMed:21795849}. |
| Q8N4X5 | AFAP1L2 | S767 | ochoa | Actin filament-associated protein 1-like 2 (AFAP1-like protein 2) | May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation. {ECO:0000269|PubMed:17412687}. |
| Q8N5W9 | RFLNB | S71 | ochoa | Refilin-B (Regulator of filamin protein B) (RefilinB) | Involved in the regulation of the perinuclear actin network and nuclear shape through interaction with filamins. Plays an essential role in the formation of cartilaginous skeletal elements. {ECO:0000250|UniProtKB:Q5SVD0}. |
| Q8NCD3 | HJURP | S557 | ochoa | Holliday junction recognition protein (14-3-3-associated AKT substrate) (Fetal liver-expressing gene 1 protein) (Up-regulated in lung cancer 9) | Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions. {ECO:0000269|PubMed:19410544, ECO:0000269|PubMed:19410545}. |
| Q8NFI3 | ENGASE | S673 | ochoa | Cytosolic endo-beta-N-acetylglucosaminidase (ENGase) (EC 3.2.1.96) | Endoglycosidase that releases N-glycans from glycoproteins by cleaving the beta-1,4-glycosidic bond in the N,N'-diacetylchitobiose core. Involved in the processing of free oligosaccharides in the cytosol. {ECO:0000269|PubMed:12114544}. |
| Q8TB61 | SLC35B2 | S137 | ochoa | Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (PAPS transporter 1) (Putative MAPK-activating protein PM15) (Putative NF-kappa-B-activating protein 48) (Solute carrier family 35 member B2) | Probably functions as a 3'-phosphoadenylyl sulfate:adenosine 3',5'-bisphosphate antiporter at the Golgi membranes. Mediates the transport from the cytosol into the lumen of the Golgi of 3'-phosphoadenylyl sulfate/adenosine 3'-phospho 5'-phosphosulfate (PAPS), a universal sulfuryl donor for sulfation events that take place in that compartment. {ECO:0000269|PubMed:12716889}. |
| Q8TBB5 | KLHDC4 | S222 | ochoa | Kelch domain-containing protein 4 | None |
| Q8TC05 | MDM1 | S314 | ochoa | Nuclear protein MDM1 | Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules (PubMed:26337392). {ECO:0000269|PubMed:26337392}. |
| Q8TEH3 | DENND1A | S546 | ochoa | DENN domain-containing protein 1A (Connecdenn 1) (Connecdenn) (Protein FAM31A) | Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes (PubMed:20154091, PubMed:20937701). Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P (By similarity). {ECO:0000250|UniProtKB:Q8K382, ECO:0000269|PubMed:20154091, ECO:0000269|PubMed:20937701}. |
| Q8TER5 | ARHGEF40 | S1480 | ochoa | Rho guanine nucleotide exchange factor 40 (Protein SOLO) | May act as a guanine nucleotide exchange factor (GEF). {ECO:0000250}. |
| Q8WUB8 | PHF10 | S270 | ochoa | PHD finger protein 10 (BRG1-associated factor 45a) (BAF45a) (XAP135) | Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250}. |
| Q8WV28 | BLNK | S129 | ochoa | B-cell linker protein (B-cell adapter containing a SH2 domain protein) (B-cell adapter containing a Src homology 2 domain protein) (Cytoplasmic adapter protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65) | Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis. {ECO:0000269|PubMed:10583958, ECO:0000269|PubMed:15270728, ECO:0000269|PubMed:16912232, ECO:0000269|PubMed:9697839}. |
| Q8WX92 | NELFB | S557 | ochoa | Negative elongation factor B (NELF-B) (Cofactor of BRCA1) | Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (PubMed:12612062). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (PubMed:10199401). May be able to induce chromatin unfolding (PubMed:11739404). Essential for early embryogenesis; plays an important role in maintaining the undifferentiated state of embryonic stem cells (ESCs) by preventing unscheduled expression of developmental genes (By similarity). Plays a key role in establishing the responsiveness of stem cells to developmental cues; facilitates plasticity and cell fate commitment in ESCs by establishing the appropriate expression level of signaling molecules (By similarity). Supports the transcription of genes involved in energy metabolism in cardiomyocytes; facilitates the association of transcription initiation factors with the promoters of the metabolism-related genes (By similarity). {ECO:0000250|UniProtKB:Q8C4Y3, ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:11739404, ECO:0000269|PubMed:12612062}.; FUNCTION: (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II (PubMed:23884411). In vitro, binds weakly to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1 (PubMed:23884411). {ECO:0000269|PubMed:23884411}. |
| Q8WX93 | PALLD | S192 | ochoa | Palladin (SIH002) (Sarcoma antigen NY-SAR-77) | Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. {ECO:0000269|PubMed:11598191, ECO:0000269|PubMed:15147863, ECO:0000269|PubMed:17537434}. |
| Q8WXG6 | MADD | S1059 | ochoa | MAP kinase-activating death domain protein (Differentially expressed in normal and neoplastic cells) (Insulinoma glucagonoma clone 20) (Rab3 GDP/GTP exchange factor) (RabGEF) (Rab3 GDP/GTP exchange protein) (Rab3GEP) | Guanyl-nucleotide exchange factor that regulates small GTPases of the Rab family (PubMed:18559336, PubMed:20937701). Converts GDP-bound inactive form of RAB27A and RAB27B to the GTP-bound active forms (PubMed:18559336, PubMed:20937701). Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms, GTPases involved in synaptic vesicle exocytosis and vesicle secretion (By similarity). Plays a role in synaptic vesicle formation and in vesicle trafficking at the neuromuscular junction (By similarity). Involved in up-regulating a post-docking step of synaptic exocytosis in central synapses (By similarity). Probably by binding to the motor proteins KIF1B and KIF1A, mediates motor-dependent transport of GTP-RAB3A-positive vesicles to the presynaptic nerve terminals (By similarity). Plays a role in TNFA-mediated activation of the MAPK pathway, including ERK1/2 (PubMed:32761064). May link TNFRSF1A with MAP kinase activation (PubMed:9115275). May be involved in the regulation of TNFA-induced apoptosis (PubMed:11577081, PubMed:32761064). {ECO:0000250|UniProtKB:O08873, ECO:0000250|UniProtKB:Q80U28, ECO:0000269|PubMed:11577081, ECO:0000269|PubMed:18559336, ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:32761064, ECO:0000269|PubMed:9115275}. |
| Q96B01 | RAD51AP1 | S294 | ochoa | RAD51-associated protein 1 (HsRAD51AP1) (RAD51-interacting protein) | Structure-specific DNA-binding protein involved in DNA repair by promoting RAD51-mediated homologous recombination (PubMed:17996710, PubMed:17996711, PubMed:20871616, PubMed:25288561, PubMed:26323318). Acts by stimulating D-Loop formation by RAD51: specifically enhances joint molecule formation through its structure-specific DNA interaction and its interaction with RAD51 (PubMed:17996710, PubMed:17996711). Binds single-stranded DNA (ssDNA), double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures: has a strong preference for branched-DNA structures that are obligatory intermediates during joint molecule formation (PubMed:17996710, PubMed:17996711, PubMed:22375013, PubMed:9396801). Cooperates with WDR48/UAF1 to stimulate RAD51-mediated homologous recombination: both WDR48/UAF1 and RAD51AP1 have coordinated role in DNA-binding during homologous recombination and DNA repair (PubMed:27239033, PubMed:27463890, PubMed:32350107). WDR48/UAF1 and RAD51AP1 also have a coordinated role in DNA-binding to promote USP1-mediated deubiquitination of FANCD2 (PubMed:31253762). Also involved in meiosis by promoting DMC1-mediated homologous meiotic recombination (PubMed:21307306). Key mediator of alternative lengthening of telomeres (ALT) pathway, a homology-directed repair mechanism of telomere elongation that controls proliferation in aggressive cancers, by stimulating homologous recombination (PubMed:31400850). May also bind RNA; additional evidences are however required to confirm RNA-binding in vivo (PubMed:9396801). {ECO:0000269|PubMed:17996710, ECO:0000269|PubMed:17996711, ECO:0000269|PubMed:20871616, ECO:0000269|PubMed:21307306, ECO:0000269|PubMed:22375013, ECO:0000269|PubMed:25288561, ECO:0000269|PubMed:26323318, ECO:0000269|PubMed:27239033, ECO:0000269|PubMed:27463890, ECO:0000269|PubMed:31253762, ECO:0000269|PubMed:31400850, ECO:0000269|PubMed:32350107, ECO:0000269|PubMed:9396801}. |
| Q96EK6 | GNPNAT1 | S27 | ochoa | Glucosamine 6-phosphate N-acetyltransferase (EC 2.3.1.4) (Phosphoglucosamine acetylase) (Phosphoglucosamine transacetylase) | None |
| Q96H55 | MYO19 | S685 | ochoa | Unconventional myosin-XIX (Myosin head domain-containing protein 1) | Actin-based motor molecule with ATPase activity that localizes to the mitochondrion outer membrane (PubMed:19932026, PubMed:23568824, PubMed:25447992). Motor protein that moves towards the plus-end of actin filaments (By similarity). Required for mitochondrial inheritance during mitosis (PubMed:25447992). May be involved in mitochondrial transport or positioning (PubMed:23568824). {ECO:0000250|UniProtKB:Q5SV80, ECO:0000269|PubMed:19932026, ECO:0000269|PubMed:25447992, ECO:0000305|PubMed:23568824}. |
| Q96IT1 | ZNF496 | S23 | ochoa | Zinc finger protein 496 (Zinc finger protein with KRAB and SCAN domains 17) | DNA-binding transcription factor that can both act as an activator and a repressor. {ECO:0000250}. |
| Q96L73 | NSD1 | S2471 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) | Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context. {ECO:0000269|PubMed:21196496}. |
| Q96NU1 | SAMD11 | S171 | ochoa | Sterile alpha motif domain-containing protein 11 (SAM domain-containing protein 11) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, essential for establishing rod photoreceptor cell identity and function by silencing nonrod gene expression in developing rod photoreceptor cells. {ECO:0000250|UniProtKB:Q1RNF8}. |
| Q96PU5 | NEDD4L | S449 | ochoa | E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2) | E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins and is thereby implicated in the regulation of various signaling pathways including autophagy, innate immunity or DNA repair (PubMed:20064473, PubMed:31959741, PubMed:33608556). Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation (PubMed:15496141). Downregulates autophagy and cell growth by ubiquitinating and reducing cellular ULK1 or ASCT2 levels (PubMed:28820317, PubMed:31959741). Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5 (PubMed:26363003, PubMed:27445338). Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Involved in the regulation of TOR signaling (PubMed:27694961). Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF (PubMed:27445338). Plays a role in antiviral innate immunity by catalyzing 'Lys-29'-linked cysteine ubiquitination of TRAF3, resulting in enhanced 'Lys-48' and 'Lys-63'-linked ubiquitination of TRAF3 (PubMed:33608556). Ubiquitinates TTYH2 and TTYH3 and regulates protein levels of TTYH2 (PubMed:18577513). {ECO:0000250|UniProtKB:Q8CFI0, ECO:0000269|PubMed:12911626, ECO:0000269|PubMed:15040001, ECO:0000269|PubMed:15217910, ECO:0000269|PubMed:15489223, ECO:0000269|PubMed:15496141, ECO:0000269|PubMed:15576372, ECO:0000269|PubMed:18577513, ECO:0000269|PubMed:19144635, ECO:0000269|PubMed:23999003, ECO:0000269|PubMed:25631046, ECO:0000269|PubMed:26363003, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:27694961, ECO:0000269|PubMed:33608556}. |
| Q96QC0 | PPP1R10 | S313 | ochoa | Serine/threonine-protein phosphatase 1 regulatory subunit 10 (MHC class I region proline-rich protein CAT53) (PP1-binding protein of 114 kDa) (Phosphatase 1 nuclear targeting subunit) (p99) | Substrate-recognition component of the PNUTS-PP1 protein phosphatase complex, a protein phosphatase 1 (PP1) complex that promotes RNA polymerase II transcription pause-release, allowing transcription elongation (PubMed:39603239, PubMed:39603240). Promoter-proximal pausing by RNA polymerase II is a transcription halt following transcription initiation but prior to elongation, which acts as a checkpoint to control that transcripts are favorably configured for transcriptional elongation (PubMed:39603239, PubMed:39603240). The PNUTS-PP1 complex mediates the release of RNA polymerase II from promoter-proximal region of genes by catalyzing dephosphorylation of proteins involved in transcription, such as AFF4, CDK9, MEPCE, INTS12, NCBP1, POLR2M/GDOWN1 and SUPT6H (PubMed:39603239, PubMed:39603240). The PNUTS-PP1 complex also regulates RNA polymerase II transcription termination by mediating dephosphorylation of SUPT5H in termination zones downstream of poly(A) sites, thereby promoting deceleration of RNA polymerase II transcription (PubMed:31677974). PNUTS-PP1 complex is also involved in the response to replication stress by mediating dephosphorylation of POLR2A at 'Ser-5' of the CTD, promoting RNA polymerase II degradation (PubMed:33264625). The PNUTS-PP1 complex also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (By similarity). PNUTS-PP1 complex mediates dephosphorylation of MYC, promoting MYC stability by preventing MYC ubiquitination by the SCF(FBXW7) complex (PubMed:30158517). In addition to acts as a substrate-recognition component, PPP1R10/PNUTS also acts as a nuclear targeting subunit for the PNUTS-PP1 complex (PubMed:9450550). In some context, PPP1R10/PNUTS also acts as an inhibitor of protein phosphatase 1 (PP1) activity by preventing access to substrates, such as RB (PubMed:18360108). {ECO:0000250|UniProtKB:Q80W00, ECO:0000269|PubMed:18360108, ECO:0000269|PubMed:30158517, ECO:0000269|PubMed:31677974, ECO:0000269|PubMed:33264625, ECO:0000269|PubMed:39603239, ECO:0000269|PubMed:39603240, ECO:0000269|PubMed:9450550}. |
| Q96QS3 | ARX | S37 | psp | Homeobox protein ARX (Aristaless-related homeobox) | Transcription factor (PubMed:22194193, PubMed:31691806). Binds to specific sequence motif 5'-TAATTA-3' in regulatory elements of target genes, such as histone demethylase KDM5C (PubMed:22194193, PubMed:31691806). Positively modulates transcription of KDM5C (PubMed:31691806). Activates expression of KDM5C synergistically with histone lysine demethylase PHF8 and perhaps in competition with transcription regulator ZNF711; synergy may be related to enrichment of histone H3K4me3 in regulatory elements (PubMed:31691806). Required for normal brain development (PubMed:11889467, PubMed:12379852, PubMed:14722918). Plays a role in neuronal proliferation, interneuronal migration and differentiation in the embryonic forebrain (By similarity). May also be involved in axonal guidance in the floor plate (By similarity). {ECO:0000250|UniProtKB:O35085, ECO:0000269|PubMed:11889467, ECO:0000269|PubMed:12379852, ECO:0000269|PubMed:14722918, ECO:0000269|PubMed:22194193, ECO:0000269|PubMed:31691806}. |
| Q96RG2 | PASK | S524 | ochoa | PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (hPASK) (EC 2.7.11.1) | Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation. {ECO:0000269|PubMed:16275910, ECO:0000269|PubMed:17052199, ECO:0000269|PubMed:17595531, ECO:0000269|PubMed:20943661, ECO:0000269|PubMed:21181396, ECO:0000269|PubMed:21418524}. |
| Q99666 | RGPD5 | S781 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q99958 | FOXC2 | S367 | psp | Forkhead box protein C2 (Forkhead-related protein FKHL14) (Mesenchyme fork head protein 1) (MFH-1 protein) (Transcription factor FKH-14) | Transcriptional activator. {ECO:0000269|PubMed:9169153}. |
| Q9BT22 | ALG1 | S242 | ochoa | Chitobiosyldiphosphodolichol beta-mannosyltransferase (EC 2.4.1.142) (Asparagine-linked glycosylation protein 1 homolog) (Beta-1,4-mannosyltransferase) (GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase) (GDP-mannose-dolichol diphosphochitobiose mannosyltransferase) (Mannosyltransferase-1) (MT-1) (hMat-1) | Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes, on the cytoplasmic face of the endoplasmic reticulum, the addition of the first mannose residues to the dolichol-linked oligosaccharide chain, to produce Man1GlcNAc(2)-PP-dolichol core oligosaccharide. Man1GlcNAc(2)-PP-dolichol is a substrate for ALG2, the following enzyme in the biosynthetic pathway. {ECO:0000269|PubMed:10704531, ECO:0000269|PubMed:14973778, ECO:0000269|PubMed:26931382}. |
| Q9BUK6 | MSTO1 | S143 | ochoa | Protein misato homolog 1 | Involved in the regulation of mitochondrial distribution and morphology (PubMed:17349998, PubMed:28544275, PubMed:28554942). Required for mitochondrial fusion and mitochondrial network formation (PubMed:28544275, PubMed:28554942). {ECO:0000269|PubMed:17349998, ECO:0000269|PubMed:28544275, ECO:0000269|PubMed:28554942}. |
| Q9BWH6 | RPAP1 | S603 | ochoa | RNA polymerase II-associated protein 1 | Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Required for interaction of the RNA polymerase II complex with acetylated histone H3. {ECO:0000269|PubMed:17643375}. |
| Q9BWT7 | CARD10 | S815 | ochoa | Caspase recruitment domain-containing protein 10 (CARD-containing MAGUK protein 3) (Carma 3) | Scaffold protein that plays an important role in mediating the activation of NF-kappa-B via BCL10 or EGFR. {ECO:0000269|PubMed:27991920}. |
| Q9BXL7 | CARD11 | S535 | ochoa | Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 1) (Carma 1) | Adapter protein that plays a key role in adaptive immune response by transducing the activation of NF-kappa-B downstream of T-cell receptor (TCR) and B-cell receptor (BCR) engagement (PubMed:11278692, PubMed:11356195, PubMed:12356734). Transduces signals downstream TCR or BCR activation via the formation of a multiprotein complex together with BCL10 and MALT1 that induces NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11356195). Upon activation in response to TCR or BCR triggering, CARD11 homooligomerizes to form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10 and subsequent recruitment of MALT1: this leads to I-kappa-B kinase (IKK) phosphorylation and degradation, and release of NF-kappa-B proteins for nuclear translocation (PubMed:24074955). Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Promotes linear ubiquitination of BCL10 by promoting the targeting of BCL10 to RNF31/HOIP (PubMed:27777308). Stimulates the phosphorylation of BCL10 (PubMed:11356195). Also activates the TORC1 signaling pathway (PubMed:28628108). {ECO:0000269|PubMed:11278692, ECO:0000269|PubMed:11356195, ECO:0000269|PubMed:12356734, ECO:0000269|PubMed:17287217, ECO:0000269|PubMed:24074955, ECO:0000269|PubMed:27777308, ECO:0000269|PubMed:28628108}. |
| Q9BY77 | POLDIP3 | S127 | ochoa|psp | Polymerase delta-interacting protein 3 (46 kDa DNA polymerase delta interaction protein) (p46) (S6K1 Aly/REF-like target) (SKAR) | Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Involved in nuclear mRNA export; probably mediated by association with the TREX complex. {ECO:0000269|PubMed:18423201, ECO:0000269|PubMed:22928037}. |
| Q9BY89 | KIAA1671 | S1293 | ochoa | Uncharacterized protein KIAA1671 | None |
| Q9BZL4 | PPP1R12C | S604 | ochoa | Protein phosphatase 1 regulatory subunit 12C (Protein phosphatase 1 myosin-binding subunit of 85 kDa) (Protein phosphatase 1 myosin-binding subunit p85) | Regulates myosin phosphatase activity. {ECO:0000269|PubMed:11399775}. |
| Q9C0A6 | SETD5 | S1198 | ochoa | Histone-lysine N-methyltransferase SETD5 (EC 2.1.1.359) (EC 2.1.1.367) (SET domain-containing protein 5) | Chromatin regulator required for brain development: acts as a regulator of RNA elongation rate, thereby regulating neural stem cell (NSC) proliferation and synaptic transmission. May act by mediating trimethylation of 'Lys-36' of histone H3 (H3K36me3), which is essential to allow on-time RNA elongation dynamics. Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. The relevance of histone methyltransferase activity is however subject to discussion. {ECO:0000250|UniProtKB:Q5XJV7}. |
| Q9C0H5 | ARHGAP39 | S644 | ochoa | Rho GTPase-activating protein 39 | None |
| Q9H334 | FOXP1 | S83 | ochoa | Forkhead box protein P1 (Mac-1-regulated forkhead) (MFH) | Transcriptional repressor (PubMed:18347093, PubMed:26647308). Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal cord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintenance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18 (By similarity). Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis (PubMed:25267198). Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor (PubMed:15286807, PubMed:18347093, PubMed:18799727). Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B (PubMed:24023716). Can negatively regulate androgen receptor signaling (PubMed:18640093). Acts as a transcriptional activator of the FBXL7 promoter; this activity is regulated by AURKA (PubMed:28218735). {ECO:0000250|UniProtKB:P58462, ECO:0000269|PubMed:15286807, ECO:0000269|PubMed:18640093, ECO:0000269|PubMed:18799727, ECO:0000269|PubMed:24023716, ECO:0000269|PubMed:25267198, ECO:0000269|PubMed:26647308, ECO:0000269|PubMed:28218735, ECO:0000305|PubMed:18347093, ECO:0000305|PubMed:24023716}.; FUNCTION: [Isoform 8]: Involved in transcriptional regulation in embryonic stem cells (ESCs). Stimulates expression of transcription factors that are required for pluripotency and decreases expression of differentiation-associated genes. Has distinct DNA-binding specifities as compared to the canonical form and preferentially binds DNA with the sequence 5'-CGATACAA-3' (or closely related sequences) (PubMed:21924763). Promotes ESC self-renewal and pluripotency (By similarity). {ECO:0000250|UniProtKB:P58462, ECO:0000269|PubMed:21924763}. |
| Q9H4B6 | SAV1 | S27 | ochoa|psp | Protein salvador homolog 1 (45 kDa WW domain protein) (hWW45) | Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:29063833). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation. {ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:19212654, ECO:0000269|PubMed:21076410, ECO:0000269|PubMed:21104395, ECO:0000269|PubMed:29063833}. |
| Q9H7N4 | SCAF1 | S161 | ochoa | Splicing factor, arginine/serine-rich 19 (SR-related C-terminal domain-associated factor 1) (SR-related and CTD-associated factor 1) (SR-related-CTD-associated factor) (SCAF) (Serine arginine-rich pre-mRNA splicing factor SR-A1) (SR-A1) | May function in pre-mRNA splicing. {ECO:0000250}. |
| Q9H869 | YY1AP1 | S252 | ochoa | YY1-associated protein 1 (Hepatocellular carcinoma susceptibility protein) (Hepatocellular carcinoma-associated protein 2) | Associates with the INO80 chromatin remodeling complex, which is responsible for transcriptional regulation, DNA repair, and replication (PubMed:27939641). Enhances transcription activation by YY1 (PubMed:14744866). Plays a role in cell cycle regulation (PubMed:17541814, PubMed:27939641). {ECO:0000269|PubMed:14744866, ECO:0000269|PubMed:17541814, ECO:0000269|PubMed:27939641}. |
| Q9NQ86 | TRIM36 | S80 | ochoa | E3 ubiquitin-protein ligase TRIM36 (EC 2.3.2.27) (RING finger protein 98) (RING-type E3 ubiquitin transferase TRIM36) (Tripartite motif-containing protein 36) (Zinc-binding protein Rbcc728) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation (PubMed:28087737). May play a role in the acrosome reaction and fertilization. {ECO:0000250|UniProtKB:Q80WG7, ECO:0000269|PubMed:28087737}. |
| Q9NQ88 | TIGAR | S157 | ochoa | Fructose-2,6-bisphosphatase TIGAR (EC 3.1.3.46) (TP53-induced glycolysis and apoptosis regulator) (TP53-induced glycolysis regulatory phosphatase) | Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate (PubMed:19015259). Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2,6-bisphosphate in a p53/TP53-dependent manner, resulting in the pentose phosphate pathway (PPP) activation and NADPH production (PubMed:16839880, PubMed:22887998). Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content, correlating with its ability to protect cells from oxidative or metabolic stress-induced cell death (PubMed:16839880, PubMed:19713938, PubMed:22887998, PubMed:23726973, PubMed:23817040). Plays a role in promoting protection against cell death during hypoxia by decreasing mitochondria ROS levels in a HK2-dependent manner through a mechanism that is independent of its fructose-bisphosphatase activity (PubMed:23185017). In response to cardiac damage stress, mediates p53-induced inhibition of myocyte mitophagy through ROS levels reduction and the subsequent inactivation of BNIP3. Reduced mitophagy results in an enhanced apoptotic myocyte cell death, and exacerbates cardiac damage (By similarity). Plays a role in adult intestinal regeneration; contributes to the growth, proliferation and survival of intestinal crypts following tissue ablation (PubMed:23726973). Plays a neuroprotective role against ischemic brain damage by enhancing PPP flux and preserving mitochondria functions (By similarity). Protects glioma cells from hypoxia- and ROS-induced cell death by inhibiting glycolysis and activating mitochondrial energy metabolism and oxygen consumption in a TKTL1-dependent and p53/TP53-independent manner (PubMed:22887998). Plays a role in cancer cell survival by promoting DNA repair through activating PPP flux in a CDK5-ATM-dependent signaling pathway during hypoxia and/or genome stress-induced DNA damage responses (PubMed:25928429). Involved in intestinal tumor progression (PubMed:23726973). {ECO:0000250|UniProtKB:Q8BZA9, ECO:0000269|PubMed:16839880, ECO:0000269|PubMed:19015259, ECO:0000269|PubMed:19713938, ECO:0000269|PubMed:22887998, ECO:0000269|PubMed:23185017, ECO:0000269|PubMed:23726973, ECO:0000269|PubMed:23817040, ECO:0000269|PubMed:25928429}. |
| Q9NQT8 | KIF13B | S1481 | ochoa | Kinesin-like protein KIF13B (Kinesin-like protein GAKIN) | Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes. {ECO:0000269|PubMed:20194617}. |
| Q9NR99 | MXRA5 | Y1306 | ochoa | Matrix-remodeling-associated protein 5 (Adhesion protein with leucine-rich repeats and immunoglobulin domains related to perlecan) (Adlican) | In kidney, has anti-inflammatory and anti-fibrotic properties by limiting the induction of chemokines, fibronectin and collagen expression in response to TGB1 and pro-inflammatory stimuli. {ECO:0000269|PubMed:27599751}. |
| Q9NRA8 | EIF4ENIF1 | S587 | ochoa|psp | Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) | EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}. |
| Q9NRH3 | TUBG2 | S80 | ochoa|psp | Tubulin gamma-2 chain (Gamma-2-tubulin) | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685). Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:38305685). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685). {ECO:0000269|PubMed:38305685}. |
| Q9NSI6 | BRWD1 | S1475 | ochoa | Bromodomain and WD repeat-containing protein 1 (WD repeat-containing protein 9) | May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000250, ECO:0000269|PubMed:21834987}. |
| Q9NYP3 | DONSON | S34 | ochoa | Protein downstream neighbor of Son (B17) | Replisome component that maintains genome stability by protecting stalled or damaged replication forks. After the induction of replication stress, required for the stabilization of stalled replication forks, the efficient activation of the intra-S-phase and G/2M cell-cycle checkpoints and the maintenance of genome stability. {ECO:0000269|PubMed:28191891}. |
| Q9NZI6 | TFCP2L1 | S37 | ochoa | Transcription factor CP2-like protein 1 (CP2-related transcriptional repressor 1) (CRTR-1) (Transcription factor LBP-9) | Transcription factor that facilitates establishment and maintenance of pluripotency in embryonic stem cells (ESCs) (PubMed:25215486, PubMed:26906118). With KLF2, acts as the major effector of self-renewal that mediates induction of pluripotency downstream of LIF/STAT3 and Wnt/beta-catenin signaling (By similarity). Required for normal duct development in the salivary gland and kidney (By similarity). Coordinates the development of the kidney collecting ducts intercalated (IC) and principal (PC) cells, which regulate acid-base and salt-water homeostasis, respectively (By similarity). Regulates the expression of IC genes including subunits B1 and D2 of the V-ATPase complex, OXGR1, CA12, SLC4A1, AQP6 and IC-specific transcription factor FOXI1 (By similarity). Also regulates the expression of JAG1 and subsequent notch signaling in the collecting duct (By similarity). JAG1 initiates notch signaling in PCs but inhibits notch signaling in ICs (By similarity). Acts as a transcriptional suppressor that may suppress UBP1-mediated transcriptional activation (By similarity). Modulates the placental expression of CYP11A1 (PubMed:10644752). {ECO:0000250|UniProtKB:Q3UNW5, ECO:0000269|PubMed:10644752, ECO:0000269|PubMed:25215486, ECO:0000269|PubMed:26906118}. |
| Q9NZM1 | MYOF | S963 | ochoa | Myoferlin (Fer-1-like protein 3) | Calcium/phospholipid-binding protein that plays a role in the plasmalemma repair mechanism of endothelial cells that permits rapid resealing of membranes disrupted by mechanical stress. Involved in endocytic recycling. Implicated in VEGF signal transduction by regulating the levels of the receptor KDR (By similarity). {ECO:0000250}. |
| Q9UGU0 | TCF20 | S1522 | ochoa | Transcription factor 20 (TCF-20) (Nuclear factor SPBP) (Protein AR1) (Stromelysin-1 PDGF-responsive element-binding protein) (SPRE-binding protein) | Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator. {ECO:0000269|PubMed:10995766}. |
| Q9UK39 | NOCT | S96 | ochoa | Nocturnin (EC 3.1.3.108) (Carbon catabolite repression 4-like protein) | Phosphatase which catalyzes the conversion of NADP(+) to NAD(+) and of NADPH to NADH (PubMed:31147539). Shows a small preference for NADPH over NADP(+) (PubMed:31147539). Represses translation and promotes degradation of target mRNA molecules (PubMed:29860338). Plays an important role in post-transcriptional regulation of metabolic genes under circadian control (By similarity). Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis (By similarity). Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance (By similarity). Promotes adipogenesis by facilitating PPARG nuclear translocation which activates its transcriptional activity (By similarity). Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone (By similarity). Critical for proper development of early embryos (By similarity). {ECO:0000250|UniProtKB:O35710, ECO:0000269|PubMed:29860338, ECO:0000269|PubMed:31147539}. |
| Q9ULK2 | ATXN7L1 | S38 | ochoa | Ataxin-7-like protein 1 (Ataxin-7-like protein 4) | None |
| Q9ULM3 | YEATS2 | S627 | ochoa | YEATS domain-containing protein 2 | Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed:18838386, PubMed:19103755, PubMed:27103431). YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr) (PubMed:27103431). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:27103431). {ECO:0000269|PubMed:18838386, ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:27103431}. |
| Q9UPQ7 | PDZRN3 | S848 | ochoa | E3 ubiquitin-protein ligase PDZRN3 (EC 2.3.2.27) (Ligand of Numb protein X 3) (PDZ domain-containing RING finger protein 3) (RING-type E3 ubiquitin transferase PDZRN3) (Semaphorin cytoplasmic domain-associated protein 3) (Protein SEMACAP3) | E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation. {ECO:0000250|UniProtKB:Q69ZS0}. |
| Q9UQ35 | SRRM2 | S1188 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y3Q8 | TSC22D4 | S370 | ochoa | TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) | Binds DNA and acts as a transcriptional repressor (PubMed:10488076). Involved in the regulation of systematic glucose homeostasis and insulin sensitivity, via transcriptional repression of downstream insulin signaling targets such as OBP2A/LCN13 (By similarity). Acts as a negative regulator of lipogenic gene expression in hepatocytes and thereby mediates the control of very low-density lipoprotein release (PubMed:23307490). May play a role in neurite elongation and survival (By similarity). {ECO:0000250|UniProtKB:Q9EQN3, ECO:0000269|PubMed:10488076, ECO:0000269|PubMed:23307490}. |
| Q9P265 | DIP2B | S134 | Sugiyama | Disco-interacting protein 2 homolog B (DIP2 homolog B) | Negatively regulates axonal outgrowth and is essential for normal synaptic transmission. Not required for regulation of axon polarity. Promotes acetylation of alpha-tubulin. {ECO:0000250|UniProtKB:Q3UH60}. |
| P47756 | CAPZB | S73 | Sugiyama | F-actin-capping protein subunit beta (CapZ beta) | F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:A9XFX6, ECO:0000269|PubMed:21834987}. |
| Q5JR12 | PPM1J | S93 | SIGNOR | Protein phosphatase 1J (EC 3.1.3.16) (Protein phosphatase 2C isoform zeta) (PP2C-zeta) | None |
| P50897 | PPT1 | S249 | Sugiyama | Palmitoyl-protein thioesterase 1 (PPT-1) (EC 3.1.2.2) (EC 3.1.2.22) (Palmitoyl-protein hydrolase 1) | Has thioesterase activity against fatty acid thioesters with 14 -18 carbons, including palmitoyl-CoA, S-palmitoyl-N-acetylcysteamine, and palmitoylated proteins (PubMed:12855696, PubMed:26731412, PubMed:8816748). In contrast to PPT2, PPT1 can hydrolyze palmitoylated proteins and palmitoylcysteine (PubMed:12855696). {ECO:0000269|PubMed:12855696, ECO:0000269|PubMed:26731412, ECO:0000269|PubMed:8816748}. |
| Q9NRA0 | SPHK2 | S377 | Sugiyama | Sphingosine kinase 2 (SK 2) (SPK 2) (EC 2.7.1.91) | Catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides (PubMed:12954646, PubMed:19168031). In contrast to prosurvival SPHK1, has a positive effect on intracellular ceramide levels, inhibits cells growth and enhances apoptosis (PubMed:16118219). In mitochondria, is important for cytochrome-c oxidase assembly and mitochondrial respiration. The SPP produced in mitochondria binds PHB2 and modulates the regulation via PHB2 of complex IV assembly and respiration (PubMed:20959514). In nucleus, plays a role in epigenetic regulation of gene expression. Interacts with HDAC1 and HDAC2 and, through SPP production, inhibits their enzymatic activity, preventing the removal of acetyl groups from lysine residues with histones. Up-regulates acetylation of histone H3-K9, histone H4-K5 and histone H2B-K12 (PubMed:19729656). In nucleus, may have an inhibitory effect on DNA synthesis and cell cycle (PubMed:12954646, PubMed:16103110). In mast cells, is the main regulator of SPP production which mediates calcium influx, NF-kappa-B activation, cytokine production, such as TNF and IL6, and degranulation of mast cells (By similarity). In dopaminergic neurons, is involved in promoting mitochondrial functions regulating ATP and ROS levels (By similarity). Also involved in the regulation of glucose and lipid metabolism (By similarity). {ECO:0000250|UniProtKB:Q9JIA7, ECO:0000269|PubMed:12954646, ECO:0000269|PubMed:16103110, ECO:0000269|PubMed:16118219, ECO:0000269|PubMed:19168031, ECO:0000269|PubMed:19729656, ECO:0000269|PubMed:20959514}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-1592230 | Mitochondrial biogenesis | 0.000232 | 3.635 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 0.012098 | 1.917 |
| R-HSA-5632968 | Defective Mismatch Repair Associated With MSH6 | 0.024051 | 1.619 |
| R-HSA-8941333 | RUNX2 regulates genes involved in differentiation of myeloid cells | 0.002529 | 2.597 |
| R-HSA-4549380 | Defective ALG1 causes CDG-1k | 0.035860 | 1.445 |
| R-HSA-8941284 | RUNX2 regulates chondrocyte maturation | 0.003414 | 2.467 |
| R-HSA-8985586 | SLIT2:ROBO1 increases RHOA activity | 0.004424 | 2.354 |
| R-HSA-209563 | Axonal growth stimulation | 0.059052 | 1.229 |
| R-HSA-165181 | Inhibition of TSC complex formation by PKB | 0.070440 | 1.152 |
| R-HSA-8941332 | RUNX2 regulates genes involved in cell migration | 0.012918 | 1.889 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.092805 | 1.032 |
| R-HSA-163210 | Formation of ATP by chemiosmotic coupling | 0.003699 | 2.432 |
| R-HSA-68952 | DNA replication initiation | 0.146402 | 0.834 |
| R-HSA-4839744 | Signaling by APC mutants | 0.156738 | 0.805 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.156738 | 0.805 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.156738 | 0.805 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.156738 | 0.805 |
| R-HSA-429947 | Deadenylation of mRNA | 0.052309 | 1.281 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.166948 | 0.777 |
| R-HSA-69091 | Polymerase switching | 0.177036 | 0.752 |
| R-HSA-69109 | Leading Strand Synthesis | 0.177036 | 0.752 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.177036 | 0.752 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.177036 | 0.752 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.177036 | 0.752 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.177036 | 0.752 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.177036 | 0.752 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.177036 | 0.752 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.061833 | 1.209 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.010495 | 1.979 |
| R-HSA-69166 | Removal of the Flap Intermediate | 0.196849 | 0.706 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 0.206576 | 0.685 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.206576 | 0.685 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.021640 | 1.665 |
| R-HSA-8853659 | RET signaling | 0.097177 | 1.012 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.253483 | 0.596 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.253483 | 0.596 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.262528 | 0.581 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.262528 | 0.581 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.262528 | 0.581 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.262528 | 0.581 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.262528 | 0.581 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.280292 | 0.552 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.280292 | 0.552 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.314553 | 0.502 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.331070 | 0.480 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.331070 | 0.480 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.339180 | 0.470 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.339180 | 0.470 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.355106 | 0.450 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.362926 | 0.440 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.362926 | 0.440 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.378283 | 0.422 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.378283 | 0.422 |
| R-HSA-390522 | Striated Muscle Contraction | 0.385823 | 0.414 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.385823 | 0.414 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.259042 | 0.587 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.259042 | 0.587 |
| R-HSA-380287 | Centrosome maturation | 0.268019 | 0.572 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.400630 | 0.397 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.299401 | 0.524 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.317247 | 0.499 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.317247 | 0.499 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.330565 | 0.481 |
| R-HSA-1989781 | PPARA activates gene expression | 0.352058 | 0.453 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.080626 | 1.094 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.358663 | 0.445 |
| R-HSA-69186 | Lagging Strand Synthesis | 0.271464 | 0.566 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.097177 | 1.012 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.065130 | 1.186 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.243497 | 0.614 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.243497 | 0.614 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 0.206576 | 0.685 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.245584 | 0.610 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.243497 | 0.614 |
| R-HSA-9603505 | NTRK3 as a dependence receptor | 0.035860 | 1.445 |
| R-HSA-174430 | Telomere C-strand synthesis initiation | 0.206576 | 0.685 |
| R-HSA-4641265 | Repression of WNT target genes | 0.177036 | 0.752 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.002570 | 2.590 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 0.235061 | 0.629 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.374371 | 0.427 |
| R-HSA-2025928 | Calcineurin activates NFAT | 0.009643 | 2.016 |
| R-HSA-69190 | DNA strand elongation | 0.370651 | 0.431 |
| R-HSA-193697 | p75NTR regulates axonogenesis | 0.135941 | 0.867 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.393271 | 0.405 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.385823 | 0.414 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 0.092805 | 1.032 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 0.187003 | 0.728 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.378283 | 0.422 |
| R-HSA-9843745 | Adipogenesis | 0.266236 | 0.575 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.116537 | 0.934 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.262528 | 0.581 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.391578 | 0.407 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.370651 | 0.431 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.071894 | 1.143 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.060475 | 1.218 |
| R-HSA-5632928 | Defective Mismatch Repair Associated With MSH2 | 0.035860 | 1.445 |
| R-HSA-8949613 | Cristae formation | 0.007927 | 2.101 |
| R-HSA-193634 | Axonal growth inhibition (RHOA activation) | 0.125352 | 0.902 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 0.135941 | 0.867 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.166948 | 0.777 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.166948 | 0.777 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 0.206576 | 0.685 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.244328 | 0.612 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.289014 | 0.539 |
| R-HSA-162588 | Budding and maturation of HIV virion | 0.362926 | 0.440 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.393271 | 0.405 |
| R-HSA-9620244 | Long-term potentiation | 0.314553 | 0.502 |
| R-HSA-5358508 | Mismatch Repair | 0.244328 | 0.612 |
| R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 0.114634 | 0.941 |
| R-HSA-9761174 | Formation of intermediate mesoderm | 0.146402 | 0.834 |
| R-HSA-9707616 | Heme signaling | 0.011014 | 1.958 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.206576 | 0.685 |
| R-HSA-2028269 | Signaling by Hippo | 0.235061 | 0.629 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 0.262528 | 0.581 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.070786 | 1.150 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.289014 | 0.539 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.196651 | 0.706 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.339180 | 0.470 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.385823 | 0.414 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.314553 | 0.502 |
| R-HSA-9733709 | Cardiogenesis | 0.012412 | 1.906 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.362926 | 0.440 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.241305 | 0.617 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.132597 | 0.877 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.100971 | 0.996 |
| R-HSA-1268020 | Mitochondrial protein import | 0.209897 | 0.678 |
| R-HSA-5423599 | Diseases of Mismatch Repair (MMR) | 0.059052 | 1.229 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 0.092805 | 1.032 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 0.020690 | 1.684 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.166948 | 0.777 |
| R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 0.166948 | 0.777 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.196849 | 0.706 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.108106 | 0.966 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.339180 | 0.470 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.352595 | 0.453 |
| R-HSA-68877 | Mitotic Prometaphase | 0.259129 | 0.586 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.112590 | 0.949 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.104805 | 0.980 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.314553 | 0.502 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.314553 | 0.502 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.168495 | 0.773 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 0.196849 | 0.706 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.331070 | 0.480 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.355106 | 0.450 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.378283 | 0.422 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.393271 | 0.405 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.021386 | 1.670 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.149247 | 0.826 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.072363 | 1.140 |
| R-HSA-9022707 | MECP2 regulates transcription factors | 0.006804 | 2.167 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 0.253483 | 0.596 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.280292 | 0.552 |
| R-HSA-392451 | G beta:gamma signalling through PI3Kgamma | 0.297631 | 0.526 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.393271 | 0.405 |
| R-HSA-162587 | HIV Life Cycle | 0.166156 | 0.779 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.075075 | 1.125 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.077266 | 1.112 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.004947 | 2.306 |
| R-HSA-9830674 | Formation of the ureteric bud | 0.049263 | 1.307 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 0.005061 | 2.296 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.400630 | 0.397 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.009333 | 2.030 |
| R-HSA-69275 | G2/M Transition | 0.106892 | 0.971 |
| R-HSA-198203 | PI3K/AKT activation | 0.146402 | 0.834 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.177036 | 0.752 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.177036 | 0.752 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.177036 | 0.752 |
| R-HSA-174362 | Transport and metabolism of PAPS | 0.206576 | 0.685 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.322862 | 0.491 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.110148 | 0.958 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.281483 | 0.551 |
| R-HSA-162906 | HIV Infection | 0.354208 | 0.451 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.055421 | 1.256 |
| R-HSA-9909396 | Circadian clock | 0.010032 | 1.999 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.078874 | 1.103 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 0.027503 | 1.561 |
| R-HSA-9675135 | Diseases of DNA repair | 0.140899 | 0.851 |
| R-HSA-9675108 | Nervous system development | 0.314380 | 0.503 |
| R-HSA-165159 | MTOR signalling | 0.124533 | 0.905 |
| R-HSA-74160 | Gene expression (Transcription) | 0.016136 | 1.792 |
| R-HSA-210747 | Regulation of gene expression in early pancreatic precursor cells | 0.012918 | 1.889 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.014170 | 1.849 |
| R-HSA-416550 | Sema4D mediated inhibition of cell attachment and migration | 0.166948 | 0.777 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.225681 | 0.647 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 0.314553 | 0.502 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.201055 | 0.697 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.355106 | 0.450 |
| R-HSA-4839726 | Chromatin organization | 0.018043 | 1.744 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.331070 | 0.480 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.280292 | 0.552 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.027297 | 1.564 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.362926 | 0.440 |
| R-HSA-9659379 | Sensory processing of sound | 0.285967 | 0.544 |
| R-HSA-212436 | Generic Transcription Pathway | 0.016014 | 1.796 |
| R-HSA-8877330 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | 0.187003 | 0.728 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.145711 | 0.837 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.081720 | 1.088 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 0.008167 | 2.088 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.046284 | 1.335 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.100971 | 0.996 |
| R-HSA-912631 | Regulation of signaling by CBL | 0.253483 | 0.596 |
| R-HSA-198753 | ERK/MAPK targets | 0.271464 | 0.566 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.289014 | 0.539 |
| R-HSA-446210 | Synthesis of UDP-N-acetyl-glucosamine | 0.297631 | 0.526 |
| R-HSA-525793 | Myogenesis | 0.322862 | 0.491 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.236628 | 0.626 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.089862 | 1.046 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.100609 | 0.997 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.032477 | 1.488 |
| R-HSA-9834899 | Specification of the neural plate border | 0.035086 | 1.455 |
| R-HSA-3214847 | HATs acetylate histones | 0.387296 | 0.412 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.287822 | 0.541 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.037071 | 1.431 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.289014 | 0.539 |
| R-HSA-4086400 | PCP/CE pathway | 0.281483 | 0.551 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.407901 | 0.389 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.387296 | 0.412 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.098479 | 1.007 |
| R-HSA-159418 | Recycling of bile acids and salts | 0.378283 | 0.422 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.016655 | 1.778 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.082441 | 1.084 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 0.020690 | 1.684 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.177036 | 0.752 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.086056 | 1.065 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.153458 | 0.814 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.355106 | 0.450 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.378283 | 0.422 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 0.385823 | 0.414 |
| R-HSA-9830364 | Formation of the nephric duct | 0.055421 | 1.256 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.355106 | 0.450 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.368552 | 0.434 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.187003 | 0.728 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.093426 | 1.030 |
| R-HSA-9830369 | Kidney development | 0.064568 | 1.190 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.285911 | 0.544 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.183516 | 0.736 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.045812 | 1.339 |
| R-HSA-166520 | Signaling by NTRKs | 0.053577 | 1.271 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.306143 | 0.514 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.306143 | 0.514 |
| R-HSA-727802 | Transport of nucleotide sugars | 0.253483 | 0.596 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.331070 | 0.480 |
| R-HSA-193807 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol | 0.331070 | 0.480 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.378283 | 0.422 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.330565 | 0.481 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 0.245584 | 0.610 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.097177 | 1.012 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.378283 | 0.422 |
| R-HSA-8964539 | Glutamate and glutamine metabolism | 0.385823 | 0.414 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.244328 | 0.612 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.142894 | 0.845 |
| R-HSA-397795 | G-protein beta:gamma signalling | 0.378283 | 0.422 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.347191 | 0.459 |
| R-HSA-449836 | Other interleukin signaling | 0.253483 | 0.596 |
| R-HSA-73887 | Death Receptor Signaling | 0.159213 | 0.798 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 0.089718 | 1.047 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.297631 | 0.526 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.351460 | 0.454 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.272508 | 0.565 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.407793 | 0.390 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.166225 | 0.779 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.201055 | 0.697 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.123720 | 0.908 |
| R-HSA-186712 | Regulation of beta-cell development | 0.196651 | 0.706 |
| R-HSA-9758941 | Gastrulation | 0.332208 | 0.479 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.223230 | 0.651 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.370651 | 0.431 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.140899 | 0.851 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.387296 | 0.412 |
| R-HSA-449147 | Signaling by Interleukins | 0.387905 | 0.411 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.272508 | 0.565 |
| R-HSA-75893 | TNF signaling | 0.183516 | 0.736 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.326133 | 0.487 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.415083 | 0.382 |
| R-HSA-2142789 | Ubiquinol biosynthesis | 0.415083 | 0.382 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.422179 | 0.375 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 0.422179 | 0.375 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.429189 | 0.367 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.429189 | 0.367 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.429189 | 0.367 |
| R-HSA-3781860 | Diseases associated with N-glycosylation of proteins | 0.429189 | 0.367 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.433621 | 0.363 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.436114 | 0.360 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.436114 | 0.360 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.436114 | 0.360 |
| R-HSA-167169 | HIV Transcription Elongation | 0.436114 | 0.360 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.436114 | 0.360 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.436114 | 0.360 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.436114 | 0.360 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.436114 | 0.360 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.442956 | 0.354 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 0.442956 | 0.354 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.445934 | 0.351 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.449716 | 0.347 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.449716 | 0.347 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.456393 | 0.341 |
| R-HSA-9710421 | Defective pyroptosis | 0.462990 | 0.334 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.462990 | 0.334 |
| R-HSA-8854214 | TBC/RABGAPs | 0.462990 | 0.334 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.466119 | 0.332 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.469508 | 0.328 |
| R-HSA-774815 | Nucleosome assembly | 0.475946 | 0.322 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.475946 | 0.322 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.475946 | 0.322 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.475946 | 0.322 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.475946 | 0.322 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.475946 | 0.322 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.482307 | 0.317 |
| R-HSA-75153 | Apoptotic execution phase | 0.482307 | 0.317 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.488591 | 0.311 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.489761 | 0.310 |
| R-HSA-73886 | Chromosome Maintenance | 0.489761 | 0.310 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.494375 | 0.306 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.497496 | 0.303 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 0.500933 | 0.300 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.501336 | 0.300 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.502133 | 0.299 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.508084 | 0.294 |
| R-HSA-69206 | G1/S Transition | 0.508958 | 0.293 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.512978 | 0.290 |
| R-HSA-9864848 | Complex IV assembly | 0.512978 | 0.290 |
| R-HSA-72187 | mRNA 3'-end processing | 0.518892 | 0.285 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.518892 | 0.285 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.518892 | 0.285 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.524734 | 0.280 |
| R-HSA-1640170 | Cell Cycle | 0.530224 | 0.276 |
| R-HSA-72649 | Translation initiation complex formation | 0.530505 | 0.275 |
| R-HSA-422475 | Axon guidance | 0.536055 | 0.271 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.536207 | 0.271 |
| R-HSA-418597 | G alpha (z) signalling events | 0.536207 | 0.271 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.536207 | 0.271 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.538681 | 0.269 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.541840 | 0.266 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.541840 | 0.266 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.541840 | 0.266 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.541840 | 0.266 |
| R-HSA-195721 | Signaling by WNT | 0.542597 | 0.266 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.547405 | 0.262 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.552903 | 0.257 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.552903 | 0.257 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.552903 | 0.257 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.556621 | 0.254 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.556621 | 0.254 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.558334 | 0.253 |
| R-HSA-191859 | snRNP Assembly | 0.558334 | 0.253 |
| R-HSA-180786 | Extension of Telomeres | 0.558334 | 0.253 |
| R-HSA-983189 | Kinesins | 0.563700 | 0.249 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.563700 | 0.249 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.563700 | 0.249 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.563700 | 0.249 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.563700 | 0.249 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.563700 | 0.249 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.563700 | 0.249 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.569000 | 0.245 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.569000 | 0.245 |
| R-HSA-211976 | Endogenous sterols | 0.569000 | 0.245 |
| R-HSA-450294 | MAP kinase activation | 0.569000 | 0.245 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.574237 | 0.241 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.574237 | 0.241 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.574237 | 0.241 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.579410 | 0.237 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.579410 | 0.237 |
| R-HSA-373755 | Semaphorin interactions | 0.579410 | 0.237 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.579410 | 0.237 |
| R-HSA-8848021 | Signaling by PTK6 | 0.579410 | 0.237 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.579410 | 0.237 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.594334 | 0.226 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.594558 | 0.226 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.599486 | 0.222 |
| R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 0.599486 | 0.222 |
| R-HSA-167172 | Transcription of the HIV genome | 0.604354 | 0.219 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.604354 | 0.219 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.613914 | 0.212 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.613914 | 0.212 |
| R-HSA-448424 | Interleukin-17 signaling | 0.613914 | 0.212 |
| R-HSA-1266738 | Developmental Biology | 0.614808 | 0.211 |
| R-HSA-9609507 | Protein localization | 0.617065 | 0.210 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.618608 | 0.209 |
| R-HSA-8978934 | Metabolism of cofactors | 0.618608 | 0.209 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.620231 | 0.207 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.623244 | 0.205 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.627825 | 0.202 |
| R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 0.629611 | 0.201 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.632350 | 0.199 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.632350 | 0.199 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.632350 | 0.199 |
| R-HSA-425397 | Transport of vitamins, nucleosides, and related molecules | 0.632350 | 0.199 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.636821 | 0.196 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.636821 | 0.196 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.638811 | 0.195 |
| R-HSA-5689603 | UCH proteinases | 0.641237 | 0.193 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.642261 | 0.192 |
| R-HSA-109581 | Apoptosis | 0.644845 | 0.191 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.645600 | 0.190 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.649911 | 0.187 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.650798 | 0.187 |
| R-HSA-5688426 | Deubiquitination | 0.652252 | 0.186 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.654169 | 0.184 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.655346 | 0.184 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.658375 | 0.182 |
| R-HSA-9833482 | PKR-mediated signaling | 0.658375 | 0.182 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.659449 | 0.181 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.674698 | 0.171 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.674698 | 0.171 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.682141 | 0.166 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.682663 | 0.166 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.686429 | 0.163 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.690245 | 0.161 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.696020 | 0.157 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.701418 | 0.154 |
| R-HSA-202424 | Downstream TCR signaling | 0.701418 | 0.154 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.701418 | 0.154 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.706051 | 0.151 |
| R-HSA-199991 | Membrane Trafficking | 0.709117 | 0.149 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.715695 | 0.145 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.722576 | 0.141 |
| R-HSA-5617833 | Cilium Assembly | 0.723601 | 0.141 |
| R-HSA-68886 | M Phase | 0.724926 | 0.140 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.726710 | 0.139 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.727556 | 0.138 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.728452 | 0.138 |
| R-HSA-5389840 | Mitochondrial translation elongation | 0.729291 | 0.137 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.729291 | 0.137 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.729291 | 0.137 |
| R-HSA-157579 | Telomere Maintenance | 0.732588 | 0.135 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.732588 | 0.135 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.733230 | 0.135 |
| R-HSA-5368286 | Mitochondrial translation initiation | 0.735845 | 0.133 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.735845 | 0.133 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.735845 | 0.133 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.735845 | 0.133 |
| R-HSA-9609690 | HCMV Early Events | 0.737937 | 0.132 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 0.739063 | 0.131 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.741377 | 0.130 |
| R-HSA-70171 | Glycolysis | 0.742241 | 0.129 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.747139 | 0.127 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.748483 | 0.126 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.748483 | 0.126 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.748483 | 0.126 |
| R-HSA-1483255 | PI Metabolism | 0.748483 | 0.126 |
| R-HSA-428157 | Sphingolipid metabolism | 0.749396 | 0.125 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 0.751547 | 0.124 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.757565 | 0.121 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.757565 | 0.121 |
| R-HSA-72172 | mRNA Splicing | 0.758253 | 0.120 |
| R-HSA-5357801 | Programmed Cell Death | 0.760425 | 0.119 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.760519 | 0.119 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.763437 | 0.117 |
| R-HSA-69239 | Synthesis of DNA | 0.766320 | 0.116 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.766320 | 0.116 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.766320 | 0.116 |
| R-HSA-211000 | Gene Silencing by RNA | 0.766320 | 0.116 |
| R-HSA-109582 | Hemostasis | 0.767897 | 0.115 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.769168 | 0.114 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.769168 | 0.114 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.769168 | 0.114 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.769168 | 0.114 |
| R-HSA-5419276 | Mitochondrial translation termination | 0.771982 | 0.112 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.771982 | 0.112 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.771982 | 0.112 |
| R-HSA-202403 | TCR signaling | 0.774761 | 0.111 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 0.774761 | 0.111 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.774761 | 0.111 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.774761 | 0.111 |
| R-HSA-6803157 | Antimicrobial peptides | 0.777507 | 0.109 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.780219 | 0.108 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.780219 | 0.108 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.782899 | 0.106 |
| R-HSA-68882 | Mitotic Anaphase | 0.783224 | 0.106 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.784699 | 0.105 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.785200 | 0.105 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.785546 | 0.105 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.789722 | 0.103 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.790744 | 0.102 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 0.793296 | 0.101 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.793296 | 0.101 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.795816 | 0.099 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.795816 | 0.099 |
| R-HSA-70326 | Glucose metabolism | 0.798307 | 0.098 |
| R-HSA-5693538 | Homology Directed Repair | 0.800767 | 0.096 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.800767 | 0.096 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.803197 | 0.095 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.803197 | 0.095 |
| R-HSA-68875 | Mitotic Prophase | 0.805597 | 0.094 |
| R-HSA-3371556 | Cellular response to heat stress | 0.807969 | 0.093 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.810312 | 0.091 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.810312 | 0.091 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.812626 | 0.090 |
| R-HSA-194138 | Signaling by VEGF | 0.819402 | 0.087 |
| R-HSA-8939211 | ESR-mediated signaling | 0.821525 | 0.085 |
| R-HSA-69481 | G2/M Checkpoints | 0.823783 | 0.084 |
| R-HSA-114608 | Platelet degranulation | 0.823783 | 0.084 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.825920 | 0.083 |
| R-HSA-157118 | Signaling by NOTCH | 0.826475 | 0.083 |
| R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 0.834279 | 0.079 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.838301 | 0.077 |
| R-HSA-9609646 | HCMV Infection | 0.842098 | 0.075 |
| R-HSA-73894 | DNA Repair | 0.843296 | 0.074 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.847087 | 0.072 |
| R-HSA-162582 | Signal Transduction | 0.847206 | 0.072 |
| R-HSA-5368287 | Mitochondrial translation | 0.849793 | 0.071 |
| R-HSA-9664407 | Parasite infection | 0.853441 | 0.069 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.853441 | 0.069 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.853441 | 0.069 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.855231 | 0.068 |
| R-HSA-1632852 | Macroautophagy | 0.855231 | 0.068 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.858747 | 0.066 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.860473 | 0.065 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.862178 | 0.064 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.867170 | 0.062 |
| R-HSA-69242 | S Phase | 0.868793 | 0.061 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.868793 | 0.061 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.871981 | 0.059 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.875092 | 0.058 |
| R-HSA-69306 | DNA Replication | 0.876619 | 0.057 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.876619 | 0.057 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.879309 | 0.056 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.879618 | 0.056 |
| R-HSA-9612973 | Autophagy | 0.881090 | 0.055 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.881944 | 0.055 |
| R-HSA-9610379 | HCMV Late Events | 0.882545 | 0.054 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.893803 | 0.049 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 0.896148 | 0.048 |
| R-HSA-5619102 | SLC transporter disorders | 0.896148 | 0.048 |
| R-HSA-8953854 | Metabolism of RNA | 0.900445 | 0.046 |
| R-HSA-72306 | tRNA processing | 0.901140 | 0.045 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.904726 | 0.043 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.904726 | 0.043 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.907045 | 0.042 |
| R-HSA-1280218 | Adaptive Immune System | 0.907355 | 0.042 |
| R-HSA-611105 | Respiratory electron transport | 0.910418 | 0.041 |
| R-HSA-168255 | Influenza Infection | 0.911515 | 0.040 |
| R-HSA-2559583 | Cellular Senescence | 0.912599 | 0.040 |
| R-HSA-3781865 | Diseases of glycosylation | 0.916804 | 0.038 |
| R-HSA-983712 | Ion channel transport | 0.921777 | 0.035 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.922599 | 0.035 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.923683 | 0.034 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 0.925542 | 0.034 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.928247 | 0.032 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.933367 | 0.030 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.936092 | 0.029 |
| R-HSA-2262752 | Cellular responses to stress | 0.941212 | 0.026 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.941829 | 0.026 |
| R-HSA-397014 | Muscle contraction | 0.941829 | 0.026 |
| R-HSA-418990 | Adherens junctions interactions | 0.945984 | 0.024 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.952263 | 0.021 |
| R-HSA-913531 | Interferon Signaling | 0.958457 | 0.018 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.962261 | 0.017 |
| R-HSA-421270 | Cell-cell junction organization | 0.964085 | 0.016 |
| R-HSA-168256 | Immune System | 0.967474 | 0.014 |
| R-HSA-8978868 | Fatty acid metabolism | 0.967653 | 0.014 |
| R-HSA-416476 | G alpha (q) signalling events | 0.969426 | 0.013 |
| R-HSA-168249 | Innate Immune System | 0.970481 | 0.013 |
| R-HSA-9679506 | SARS-CoV Infections | 0.972577 | 0.012 |
| R-HSA-446728 | Cell junction organization | 0.974297 | 0.011 |
| R-HSA-72766 | Translation | 0.974342 | 0.011 |
| R-HSA-9658195 | Leishmania infection | 0.975235 | 0.011 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.975235 | 0.011 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.975607 | 0.011 |
| R-HSA-1483257 | Phospholipid metabolism | 0.979185 | 0.009 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.979185 | 0.009 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.980540 | 0.009 |
| R-HSA-6798695 | Neutrophil degranulation | 0.980952 | 0.008 |
| R-HSA-112316 | Neuronal System | 0.983071 | 0.007 |
| R-HSA-1500931 | Cell-Cell communication | 0.983964 | 0.007 |
| R-HSA-8957322 | Metabolism of steroids | 0.985483 | 0.006 |
| R-HSA-1474244 | Extracellular matrix organization | 0.986693 | 0.006 |
| R-HSA-9824446 | Viral Infection Pathways | 0.987963 | 0.005 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.989365 | 0.005 |
| R-HSA-211859 | Biological oxidations | 0.990674 | 0.004 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.991178 | 0.004 |
| R-HSA-597592 | Post-translational protein modification | 0.993876 | 0.003 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.994229 | 0.003 |
| R-HSA-5668914 | Diseases of metabolism | 0.996035 | 0.002 |
| R-HSA-388396 | GPCR downstream signalling | 0.996926 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 0.998423 | 0.001 |
| R-HSA-372790 | Signaling by GPCR | 0.998719 | 0.001 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.999642 | 0.000 |
| R-HSA-5663205 | Infectious disease | 0.999745 | 0.000 |
| R-HSA-392499 | Metabolism of proteins | 0.999914 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 0.999952 | 0.000 |
| R-HSA-9752946 | Expression and translocation of olfactory receptors | 0.999961 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999982 | 0.000 |
| R-HSA-1643685 | Disease | 0.999985 | 0.000 |
| R-HSA-381753 | Olfactory Signaling Pathway | 0.999985 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
HIPK2 |
0.866 | 0.801 | 1 | 0.830 |
P38G |
0.861 | 0.878 | 1 | 0.889 |
KIS |
0.860 | 0.763 | 1 | 0.780 |
CDK7 |
0.860 | 0.833 | 1 | 0.805 |
CDK19 |
0.859 | 0.817 | 1 | 0.837 |
CDK17 |
0.859 | 0.854 | 1 | 0.881 |
CDK3 |
0.859 | 0.772 | 1 | 0.875 |
CDK18 |
0.858 | 0.833 | 1 | 0.852 |
JNK2 |
0.855 | 0.880 | 1 | 0.848 |
CDK8 |
0.855 | 0.819 | 1 | 0.803 |
CDK1 |
0.852 | 0.822 | 1 | 0.830 |
DYRK2 |
0.852 | 0.783 | 1 | 0.747 |
DYRK4 |
0.850 | 0.793 | 1 | 0.843 |
CDK13 |
0.849 | 0.823 | 1 | 0.827 |
CDK12 |
0.849 | 0.829 | 1 | 0.848 |
P38D |
0.849 | 0.848 | 1 | 0.891 |
CDK5 |
0.849 | 0.797 | 1 | 0.778 |
CDK10 |
0.847 | 0.790 | 1 | 0.825 |
CDK9 |
0.847 | 0.823 | 1 | 0.821 |
CDK16 |
0.847 | 0.810 | 1 | 0.869 |
DYRK1B |
0.846 | 0.774 | 1 | 0.797 |
CLK3 |
0.846 | 0.548 | 1 | 0.504 |
HIPK1 |
0.846 | 0.740 | 1 | 0.728 |
ERK1 |
0.845 | 0.818 | 1 | 0.835 |
JNK3 |
0.845 | 0.863 | 1 | 0.825 |
P38B |
0.844 | 0.822 | 1 | 0.821 |
CDK14 |
0.840 | 0.812 | 1 | 0.810 |
HIPK4 |
0.840 | 0.522 | 1 | 0.528 |
CDK4 |
0.838 | 0.822 | 1 | 0.854 |
P38A |
0.836 | 0.797 | 1 | 0.749 |
SRPK1 |
0.835 | 0.386 | -3 | 0.760 |
HIPK3 |
0.835 | 0.717 | 1 | 0.699 |
DYRK1A |
0.833 | 0.645 | 1 | 0.709 |
NLK |
0.833 | 0.752 | 1 | 0.538 |
ERK2 |
0.833 | 0.818 | 1 | 0.784 |
CLK1 |
0.832 | 0.491 | -3 | 0.782 |
CLK2 |
0.832 | 0.473 | -3 | 0.779 |
CDK6 |
0.831 | 0.786 | 1 | 0.829 |
DYRK3 |
0.830 | 0.607 | 1 | 0.690 |
CLK4 |
0.827 | 0.456 | -3 | 0.788 |
CDK2 |
0.827 | 0.654 | 1 | 0.710 |
SRPK2 |
0.825 | 0.317 | -3 | 0.694 |
JNK1 |
0.822 | 0.767 | 1 | 0.851 |
ERK5 |
0.819 | 0.403 | 1 | 0.458 |
ICK |
0.814 | 0.389 | -3 | 0.824 |
MTOR |
0.813 | 0.223 | 1 | 0.340 |
MAK |
0.811 | 0.514 | -2 | 0.753 |
CDKL5 |
0.811 | 0.192 | -3 | 0.792 |
SRPK3 |
0.810 | 0.276 | -3 | 0.724 |
MOK |
0.808 | 0.508 | 1 | 0.616 |
COT |
0.807 | -0.061 | 2 | 0.881 |
NDR2 |
0.807 | 0.045 | -3 | 0.836 |
CDKL1 |
0.806 | 0.171 | -3 | 0.794 |
PRP4 |
0.804 | 0.483 | -3 | 0.746 |
PRKD2 |
0.804 | 0.079 | -3 | 0.807 |
PRKD1 |
0.803 | 0.044 | -3 | 0.832 |
PIM3 |
0.801 | 0.017 | -3 | 0.825 |
NDR1 |
0.801 | 0.031 | -3 | 0.833 |
MOS |
0.800 | -0.003 | 1 | 0.206 |
RSK2 |
0.798 | 0.055 | -3 | 0.793 |
CAMK1B |
0.798 | 0.036 | -3 | 0.855 |
MST4 |
0.798 | 0.015 | 2 | 0.864 |
RSK3 |
0.798 | 0.041 | -3 | 0.788 |
CDC7 |
0.798 | -0.100 | 1 | 0.164 |
PKN3 |
0.797 | 0.000 | -3 | 0.827 |
PRPK |
0.797 | -0.076 | -1 | 0.853 |
PIM1 |
0.796 | 0.078 | -3 | 0.786 |
P90RSK |
0.796 | 0.050 | -3 | 0.793 |
AURC |
0.796 | 0.081 | -2 | 0.729 |
TBK1 |
0.795 | -0.155 | 1 | 0.129 |
GCN2 |
0.795 | -0.167 | 2 | 0.828 |
NUAK2 |
0.795 | 0.057 | -3 | 0.843 |
P70S6KB |
0.793 | 0.058 | -3 | 0.811 |
RAF1 |
0.792 | -0.163 | 1 | 0.147 |
LATS2 |
0.792 | 0.011 | -5 | 0.811 |
IKKE |
0.792 | -0.161 | 1 | 0.127 |
WNK1 |
0.792 | -0.033 | -2 | 0.899 |
CAMLCK |
0.792 | 0.047 | -2 | 0.899 |
MAPKAPK3 |
0.791 | 0.003 | -3 | 0.794 |
ATR |
0.791 | -0.050 | 1 | 0.205 |
PRKD3 |
0.791 | 0.055 | -3 | 0.780 |
PKCD |
0.791 | 0.015 | 2 | 0.799 |
ERK7 |
0.791 | 0.266 | 2 | 0.538 |
NIK |
0.790 | 0.005 | -3 | 0.860 |
PKN2 |
0.790 | -0.014 | -3 | 0.830 |
PKACG |
0.790 | 0.032 | -2 | 0.799 |
MNK2 |
0.790 | 0.039 | -2 | 0.847 |
AMPKA1 |
0.789 | -0.007 | -3 | 0.855 |
PAK6 |
0.788 | 0.068 | -2 | 0.781 |
BMPR2 |
0.788 | -0.162 | -2 | 0.897 |
IKKB |
0.788 | -0.167 | -2 | 0.777 |
PDHK4 |
0.788 | -0.176 | 1 | 0.215 |
ULK2 |
0.787 | -0.194 | 2 | 0.806 |
AMPKA2 |
0.787 | 0.014 | -3 | 0.835 |
MAPKAPK2 |
0.787 | 0.013 | -3 | 0.748 |
NEK6 |
0.787 | -0.091 | -2 | 0.862 |
DAPK2 |
0.787 | 0.016 | -3 | 0.854 |
MNK1 |
0.786 | 0.055 | -2 | 0.858 |
DSTYK |
0.786 | -0.154 | 2 | 0.891 |
TGFBR2 |
0.786 | -0.083 | -2 | 0.804 |
SKMLCK |
0.786 | -0.018 | -2 | 0.899 |
PKACB |
0.786 | 0.081 | -2 | 0.745 |
CHAK2 |
0.785 | -0.054 | -1 | 0.832 |
PAK3 |
0.785 | -0.001 | -2 | 0.848 |
RSK4 |
0.785 | 0.056 | -3 | 0.765 |
PAK1 |
0.784 | 0.015 | -2 | 0.846 |
PDHK1 |
0.784 | -0.181 | 1 | 0.193 |
TSSK1 |
0.784 | -0.003 | -3 | 0.880 |
AKT2 |
0.784 | 0.084 | -3 | 0.723 |
CAMK2G |
0.783 | -0.100 | 2 | 0.829 |
PHKG1 |
0.783 | -0.020 | -3 | 0.833 |
PIM2 |
0.783 | 0.081 | -3 | 0.771 |
AURB |
0.782 | 0.051 | -2 | 0.727 |
LATS1 |
0.782 | 0.046 | -3 | 0.841 |
MARK4 |
0.781 | -0.063 | 4 | 0.829 |
PKG2 |
0.781 | 0.050 | -2 | 0.743 |
PRKX |
0.781 | 0.096 | -3 | 0.718 |
MELK |
0.781 | -0.017 | -3 | 0.830 |
NUAK1 |
0.781 | 0.002 | -3 | 0.816 |
BCKDK |
0.780 | -0.142 | -1 | 0.813 |
CAMK2D |
0.780 | -0.071 | -3 | 0.836 |
CAMK4 |
0.780 | -0.045 | -3 | 0.828 |
DNAPK |
0.780 | -0.027 | 1 | 0.197 |
SGK3 |
0.780 | 0.048 | -3 | 0.774 |
PKCB |
0.780 | -0.001 | 2 | 0.746 |
HUNK |
0.780 | -0.151 | 2 | 0.833 |
WNK3 |
0.779 | -0.169 | 1 | 0.148 |
TSSK2 |
0.779 | -0.051 | -5 | 0.843 |
RIPK3 |
0.779 | -0.157 | 3 | 0.680 |
MSK2 |
0.778 | 0.002 | -3 | 0.740 |
PKCG |
0.778 | -0.011 | 2 | 0.750 |
IRE1 |
0.778 | -0.099 | 1 | 0.142 |
ULK1 |
0.778 | -0.180 | -3 | 0.750 |
ATM |
0.777 | -0.073 | 1 | 0.175 |
NEK7 |
0.777 | -0.207 | -3 | 0.756 |
PKCA |
0.777 | -0.005 | 2 | 0.738 |
NIM1 |
0.777 | -0.074 | 3 | 0.731 |
MLK2 |
0.777 | -0.124 | 2 | 0.842 |
IKKA |
0.777 | -0.112 | -2 | 0.758 |
PKCZ |
0.776 | -0.021 | 2 | 0.791 |
MASTL |
0.776 | -0.165 | -2 | 0.830 |
GRK1 |
0.776 | -0.056 | -2 | 0.812 |
MLK1 |
0.775 | -0.181 | 2 | 0.823 |
MSK1 |
0.775 | 0.023 | -3 | 0.750 |
NEK9 |
0.775 | -0.184 | 2 | 0.850 |
AKT1 |
0.774 | 0.066 | -3 | 0.740 |
IRE2 |
0.774 | -0.084 | 2 | 0.760 |
DCAMKL1 |
0.774 | 0.020 | -3 | 0.818 |
PKR |
0.774 | -0.068 | 1 | 0.161 |
PAK2 |
0.773 | -0.021 | -2 | 0.832 |
GRK5 |
0.773 | -0.188 | -3 | 0.780 |
CAMK2A |
0.773 | -0.008 | 2 | 0.818 |
RIPK1 |
0.773 | -0.183 | 1 | 0.137 |
PKCH |
0.772 | -0.029 | 2 | 0.733 |
DLK |
0.772 | -0.200 | 1 | 0.163 |
PHKG2 |
0.772 | -0.012 | -3 | 0.832 |
BRSK1 |
0.772 | -0.027 | -3 | 0.813 |
CAMK2B |
0.772 | -0.040 | 2 | 0.803 |
SIK |
0.772 | -0.014 | -3 | 0.785 |
BRSK2 |
0.772 | -0.048 | -3 | 0.834 |
PINK1 |
0.772 | 0.151 | 1 | 0.356 |
BMPR1B |
0.772 | -0.063 | 1 | 0.135 |
ALK4 |
0.772 | -0.071 | -2 | 0.831 |
MYLK4 |
0.772 | 0.012 | -2 | 0.838 |
MLK3 |
0.772 | -0.089 | 2 | 0.758 |
QSK |
0.771 | -0.024 | 4 | 0.801 |
VRK2 |
0.771 | 0.030 | 1 | 0.253 |
QIK |
0.771 | -0.071 | -3 | 0.827 |
AURA |
0.771 | 0.020 | -2 | 0.700 |
MPSK1 |
0.771 | 0.037 | 1 | 0.213 |
TGFBR1 |
0.771 | -0.068 | -2 | 0.802 |
PKACA |
0.770 | 0.062 | -2 | 0.699 |
PAK5 |
0.770 | 0.032 | -2 | 0.718 |
CAMK1G |
0.769 | -0.014 | -3 | 0.783 |
GRK7 |
0.769 | -0.028 | 1 | 0.189 |
CHAK1 |
0.769 | -0.123 | 2 | 0.811 |
SMG1 |
0.769 | -0.070 | 1 | 0.191 |
PKCT |
0.769 | -0.013 | 2 | 0.742 |
CHK1 |
0.768 | -0.033 | -3 | 0.833 |
ANKRD3 |
0.768 | -0.205 | 1 | 0.164 |
YSK4 |
0.768 | -0.160 | 1 | 0.134 |
P70S6K |
0.768 | 0.017 | -3 | 0.729 |
TTBK2 |
0.767 | -0.191 | 2 | 0.730 |
NEK2 |
0.767 | -0.138 | 2 | 0.826 |
GRK6 |
0.766 | -0.170 | 1 | 0.150 |
PAK4 |
0.766 | 0.035 | -2 | 0.722 |
MAPKAPK5 |
0.766 | -0.061 | -3 | 0.719 |
DCAMKL2 |
0.765 | -0.006 | -3 | 0.841 |
MEK1 |
0.765 | -0.145 | 2 | 0.861 |
GSK3A |
0.765 | 0.174 | 4 | 0.429 |
SBK |
0.764 | 0.159 | -3 | 0.623 |
SNRK |
0.764 | -0.120 | 2 | 0.684 |
AKT3 |
0.763 | 0.066 | -3 | 0.657 |
MST3 |
0.763 | -0.035 | 2 | 0.846 |
PKCI |
0.762 | -0.002 | 2 | 0.754 |
TAO3 |
0.762 | -0.020 | 1 | 0.179 |
WNK4 |
0.762 | -0.093 | -2 | 0.882 |
PKN1 |
0.762 | 0.008 | -3 | 0.752 |
SGK1 |
0.762 | 0.085 | -3 | 0.639 |
ALK2 |
0.762 | -0.091 | -2 | 0.813 |
FAM20C |
0.761 | -0.030 | 2 | 0.632 |
ACVR2B |
0.761 | -0.108 | -2 | 0.810 |
SSTK |
0.761 | -0.024 | 4 | 0.802 |
PLK1 |
0.761 | -0.162 | -2 | 0.823 |
IRAK4 |
0.761 | -0.108 | 1 | 0.126 |
MARK3 |
0.761 | -0.050 | 4 | 0.757 |
CAMK1D |
0.761 | 0.016 | -3 | 0.733 |
HRI |
0.761 | -0.151 | -2 | 0.862 |
SMMLCK |
0.760 | 0.007 | -3 | 0.818 |
GRK4 |
0.760 | -0.203 | -2 | 0.836 |
PKCE |
0.760 | 0.031 | 2 | 0.736 |
DRAK1 |
0.760 | -0.138 | 1 | 0.126 |
ACVR2A |
0.760 | -0.116 | -2 | 0.797 |
PERK |
0.759 | -0.146 | -2 | 0.845 |
MEK5 |
0.759 | -0.148 | 2 | 0.842 |
MEKK1 |
0.758 | -0.159 | 1 | 0.158 |
PLK4 |
0.758 | -0.140 | 2 | 0.655 |
MRCKB |
0.758 | 0.064 | -3 | 0.769 |
MARK2 |
0.758 | -0.068 | 4 | 0.724 |
MRCKA |
0.758 | 0.061 | -3 | 0.778 |
MLK4 |
0.757 | -0.154 | 2 | 0.739 |
TAO2 |
0.756 | -0.028 | 2 | 0.857 |
ZAK |
0.756 | -0.168 | 1 | 0.146 |
TLK2 |
0.756 | -0.163 | 1 | 0.135 |
LKB1 |
0.756 | -0.024 | -3 | 0.794 |
CHK2 |
0.755 | 0.028 | -3 | 0.680 |
PLK3 |
0.754 | -0.147 | 2 | 0.784 |
ROCK2 |
0.754 | 0.058 | -3 | 0.801 |
BRAF |
0.754 | -0.142 | -4 | 0.814 |
MARK1 |
0.754 | -0.081 | 4 | 0.787 |
MEKK2 |
0.754 | -0.142 | 2 | 0.823 |
NEK5 |
0.753 | -0.165 | 1 | 0.145 |
DAPK3 |
0.753 | 0.018 | -3 | 0.814 |
BMPR1A |
0.753 | -0.084 | 1 | 0.126 |
PASK |
0.753 | -0.042 | -3 | 0.820 |
GAK |
0.752 | -0.031 | 1 | 0.207 |
PBK |
0.752 | -0.002 | 1 | 0.189 |
LOK |
0.752 | -0.030 | -2 | 0.811 |
PDK1 |
0.751 | -0.057 | 1 | 0.189 |
BUB1 |
0.751 | 0.027 | -5 | 0.772 |
MEKK3 |
0.751 | -0.194 | 1 | 0.152 |
TNIK |
0.751 | -0.026 | 3 | 0.870 |
MEKK6 |
0.751 | -0.085 | 1 | 0.160 |
GRK2 |
0.751 | -0.114 | -2 | 0.721 |
GCK |
0.751 | -0.061 | 1 | 0.151 |
TLK1 |
0.750 | -0.158 | -2 | 0.833 |
DMPK1 |
0.750 | 0.097 | -3 | 0.788 |
CAMK1A |
0.750 | 0.019 | -3 | 0.696 |
HGK |
0.749 | -0.066 | 3 | 0.859 |
GSK3B |
0.749 | 0.023 | 4 | 0.420 |
NEK11 |
0.749 | -0.145 | 1 | 0.172 |
KHS1 |
0.749 | -0.023 | 1 | 0.146 |
MAP3K15 |
0.748 | -0.097 | 1 | 0.160 |
HASPIN |
0.748 | 0.048 | -1 | 0.724 |
HPK1 |
0.748 | -0.052 | 1 | 0.150 |
PKG1 |
0.747 | 0.024 | -2 | 0.671 |
KHS2 |
0.747 | -0.001 | 1 | 0.155 |
LRRK2 |
0.746 | -0.012 | 2 | 0.854 |
CK1E |
0.746 | -0.067 | -3 | 0.439 |
CRIK |
0.745 | 0.062 | -3 | 0.727 |
CAMKK1 |
0.745 | -0.181 | -2 | 0.803 |
NEK4 |
0.744 | -0.159 | 1 | 0.127 |
NEK8 |
0.744 | -0.178 | 2 | 0.824 |
DAPK1 |
0.744 | 0.001 | -3 | 0.793 |
ROCK1 |
0.744 | 0.051 | -3 | 0.778 |
MINK |
0.744 | -0.117 | 1 | 0.128 |
SLK |
0.742 | -0.054 | -2 | 0.745 |
IRAK1 |
0.742 | -0.217 | -1 | 0.767 |
CAMKK2 |
0.742 | -0.147 | -2 | 0.797 |
TTBK1 |
0.741 | -0.179 | 2 | 0.648 |
BIKE |
0.740 | -0.011 | 1 | 0.202 |
NEK1 |
0.740 | -0.149 | 1 | 0.127 |
EEF2K |
0.740 | -0.097 | 3 | 0.818 |
YSK1 |
0.740 | -0.098 | 2 | 0.819 |
CK2A2 |
0.739 | -0.090 | 1 | 0.116 |
MST2 |
0.739 | -0.157 | 1 | 0.141 |
AAK1 |
0.738 | 0.023 | 1 | 0.209 |
VRK1 |
0.738 | -0.160 | 2 | 0.845 |
LIMK2_TYR |
0.737 | 0.173 | -3 | 0.863 |
PDHK3_TYR |
0.737 | 0.136 | 4 | 0.901 |
CK1D |
0.737 | -0.047 | -3 | 0.385 |
MST1 |
0.736 | -0.142 | 1 | 0.129 |
NEK3 |
0.735 | -0.115 | 1 | 0.158 |
TAK1 |
0.735 | -0.193 | 1 | 0.134 |
CK1G1 |
0.735 | -0.111 | -3 | 0.433 |
TESK1_TYR |
0.733 | 0.073 | 3 | 0.853 |
TAO1 |
0.733 | -0.052 | 1 | 0.148 |
MEK2 |
0.733 | -0.184 | 2 | 0.832 |
RIPK2 |
0.732 | -0.211 | 1 | 0.127 |
GRK3 |
0.731 | -0.126 | -2 | 0.674 |
CK1A2 |
0.731 | -0.073 | -3 | 0.389 |
PKMYT1_TYR |
0.730 | 0.120 | 3 | 0.809 |
STK33 |
0.729 | -0.141 | 2 | 0.643 |
CK2A1 |
0.729 | -0.101 | 1 | 0.107 |
OSR1 |
0.727 | -0.086 | 2 | 0.819 |
MYO3B |
0.727 | -0.069 | 2 | 0.838 |
MAP2K4_TYR |
0.726 | 0.006 | -1 | 0.875 |
PDHK4_TYR |
0.726 | 0.035 | 2 | 0.891 |
ASK1 |
0.725 | -0.125 | 1 | 0.162 |
MAP2K7_TYR |
0.725 | -0.065 | 2 | 0.875 |
LIMK1_TYR |
0.724 | 0.037 | 2 | 0.869 |
PINK1_TYR |
0.724 | -0.082 | 1 | 0.209 |
PLK2 |
0.723 | -0.113 | -3 | 0.709 |
MAP2K6_TYR |
0.723 | 0.000 | -1 | 0.875 |
RET |
0.723 | -0.101 | 1 | 0.179 |
BMPR2_TYR |
0.721 | -0.005 | -1 | 0.870 |
TTK |
0.720 | -0.103 | -2 | 0.830 |
NEK10_TYR |
0.720 | -0.059 | 1 | 0.156 |
MYO3A |
0.720 | -0.096 | 1 | 0.143 |
MST1R |
0.717 | -0.102 | 3 | 0.765 |
JAK2 |
0.716 | -0.128 | 1 | 0.190 |
TYK2 |
0.716 | -0.184 | 1 | 0.167 |
EPHA6 |
0.716 | -0.094 | -1 | 0.872 |
PDHK1_TYR |
0.715 | -0.100 | -1 | 0.890 |
CSF1R |
0.715 | -0.109 | 3 | 0.750 |
JAK3 |
0.714 | -0.102 | 1 | 0.176 |
ROS1 |
0.714 | -0.130 | 3 | 0.744 |
DDR1 |
0.714 | -0.087 | 4 | 0.853 |
TNNI3K_TYR |
0.714 | -0.030 | 1 | 0.188 |
TNK1 |
0.713 | -0.042 | 3 | 0.753 |
TYRO3 |
0.713 | -0.154 | 3 | 0.776 |
EPHB4 |
0.712 | -0.127 | -1 | 0.857 |
ABL2 |
0.712 | -0.107 | -1 | 0.809 |
YES1 |
0.711 | -0.098 | -1 | 0.862 |
JAK1 |
0.710 | -0.101 | 1 | 0.160 |
TXK |
0.710 | -0.095 | 1 | 0.135 |
ALPHAK3 |
0.710 | -0.120 | -1 | 0.760 |
FGFR2 |
0.709 | -0.049 | 3 | 0.711 |
ABL1 |
0.708 | -0.117 | -1 | 0.802 |
FGFR1 |
0.708 | -0.050 | 3 | 0.705 |
TEK |
0.707 | -0.021 | 3 | 0.686 |
STLK3 |
0.707 | -0.181 | 1 | 0.127 |
FGR |
0.705 | -0.171 | 1 | 0.144 |
DDR2 |
0.704 | -0.013 | 3 | 0.650 |
LCK |
0.704 | -0.111 | -1 | 0.849 |
KDR |
0.704 | -0.099 | 3 | 0.700 |
TNK2 |
0.703 | -0.132 | 3 | 0.695 |
YANK3 |
0.703 | -0.080 | 2 | 0.423 |
INSRR |
0.703 | -0.150 | 3 | 0.683 |
ITK |
0.703 | -0.146 | -1 | 0.817 |
PDGFRB |
0.703 | -0.197 | 3 | 0.766 |
BLK |
0.702 | -0.098 | -1 | 0.854 |
HCK |
0.702 | -0.160 | -1 | 0.848 |
FLT3 |
0.702 | -0.177 | 3 | 0.767 |
KIT |
0.701 | -0.150 | 3 | 0.744 |
EPHA4 |
0.698 | -0.120 | 2 | 0.782 |
AXL |
0.698 | -0.174 | 3 | 0.721 |
PDGFRA |
0.698 | -0.206 | 3 | 0.766 |
FER |
0.698 | -0.224 | 1 | 0.158 |
EPHB1 |
0.698 | -0.195 | 1 | 0.139 |
EPHB3 |
0.697 | -0.182 | -1 | 0.846 |
MET |
0.697 | -0.131 | 3 | 0.734 |
SRMS |
0.696 | -0.203 | 1 | 0.132 |
EPHB2 |
0.696 | -0.169 | -1 | 0.840 |
MERTK |
0.696 | -0.170 | 3 | 0.719 |
WEE1_TYR |
0.696 | -0.096 | -1 | 0.750 |
FGFR3 |
0.695 | -0.081 | 3 | 0.680 |
BMX |
0.694 | -0.131 | -1 | 0.729 |
BTK |
0.693 | -0.206 | -1 | 0.787 |
TEC |
0.693 | -0.159 | -1 | 0.756 |
ALK |
0.692 | -0.173 | 3 | 0.657 |
FYN |
0.692 | -0.107 | -1 | 0.831 |
EPHA1 |
0.691 | -0.167 | 3 | 0.713 |
FLT1 |
0.691 | -0.147 | -1 | 0.842 |
CK1A |
0.691 | -0.097 | -3 | 0.294 |
ERBB2 |
0.691 | -0.173 | 1 | 0.156 |
FRK |
0.691 | -0.163 | -1 | 0.857 |
LTK |
0.690 | -0.179 | 3 | 0.677 |
FLT4 |
0.690 | -0.159 | 3 | 0.686 |
EPHA7 |
0.689 | -0.158 | 2 | 0.784 |
INSR |
0.688 | -0.175 | 3 | 0.672 |
PTK2B |
0.688 | -0.123 | -1 | 0.787 |
EGFR |
0.686 | -0.123 | 1 | 0.139 |
NTRK1 |
0.685 | -0.240 | -1 | 0.824 |
NTRK2 |
0.685 | -0.232 | 3 | 0.690 |
MUSK |
0.685 | -0.138 | 1 | 0.124 |
EPHA3 |
0.684 | -0.171 | 2 | 0.756 |
PTK6 |
0.683 | -0.231 | -1 | 0.742 |
LYN |
0.682 | -0.175 | 3 | 0.668 |
NTRK3 |
0.682 | -0.189 | -1 | 0.776 |
SRC |
0.681 | -0.146 | -1 | 0.826 |
EPHA8 |
0.681 | -0.146 | -1 | 0.827 |
EPHA5 |
0.679 | -0.169 | 2 | 0.765 |
MATK |
0.679 | -0.134 | -1 | 0.726 |
CSK |
0.676 | -0.181 | 2 | 0.787 |
FGFR4 |
0.676 | -0.142 | -1 | 0.774 |
PTK2 |
0.674 | -0.086 | -1 | 0.803 |
SYK |
0.673 | -0.110 | -1 | 0.787 |
ERBB4 |
0.671 | -0.114 | 1 | 0.136 |
IGF1R |
0.670 | -0.168 | 3 | 0.601 |
EPHA2 |
0.669 | -0.160 | -1 | 0.792 |
CK1G3 |
0.667 | -0.109 | -3 | 0.247 |
YANK2 |
0.665 | -0.109 | 2 | 0.440 |
ZAP70 |
0.662 | -0.083 | -1 | 0.688 |
FES |
0.650 | -0.192 | -1 | 0.706 |
CK1G2 |
0.644 | -0.109 | -3 | 0.346 |