Motif 833 (n=247)
Position-wise Probabilities
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uniprot | genes | site | source | protein | function |
---|---|---|---|---|---|
A0A087X0R7 | SENP3-EIF4A1 | S142 | ochoa | SENP3-EIF4A1 readthrough (NMD candidate) | None |
A0JNW5 | BLTP3B | S884 | ochoa | Bridge-like lipid transfer protein family member 3B (Syntaxin-6 Habc-interacting protein of 164 kDa) (UHRF1-binding protein 1-like) | Tube-forming lipid transport protein which mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567). Required for retrograde traffic of vesicle clusters in the early endocytic pathway to the Golgi complex (PubMed:20163565, PubMed:35499567). {ECO:0000269|PubMed:20163565, ECO:0000269|PubMed:35499567}. |
A2A2Y4 | FRMD3 | S409 | ochoa | FERM domain-containing protein 3 (Band 4.1-like protein 4O) (Ovary type protein 4.1) (4.1O) | Putative tumor suppressor gene that may be implicated in the origin and progression of lung cancer. {ECO:0000269|PubMed:17260017}. |
A2RU67 | FAM234B | S52 | ochoa | Protein FAM234B | None |
A5PKW4 | PSD | S990 | ochoa | PH and SEC7 domain-containing protein 1 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6) (Exchange factor for ARF6) (Exchange factor for ARF6 A) (Pleckstrin homology and SEC7 domain-containing protein 1) | Guanine nucleotide exchange factor for ARF6 (PubMed:23603394). Induces cytoskeletal remodeling (By similarity). {ECO:0000250|UniProtKB:Q5DTT2, ECO:0000269|PubMed:23603394}. |
A6NMY6 | ANXA2P2 | S26 | ochoa | Putative annexin A2-like protein (Annexin A2 pseudogene 2) (Lipocortin II pseudogene) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. {ECO:0000250}. |
H3BM21 | None | S92 | ochoa | Integrin beta | None |
O00116 | AGPS | S149 | ochoa | Alkyldihydroxyacetonephosphate synthase, peroxisomal (Alkyl-DHAP synthase) (EC 2.5.1.26) (Aging-associated gene 5 protein) (Alkylglycerone-phosphate synthase) | Catalyzes the exchange of the acyl chain in acyl-dihydroxyacetonephosphate (acyl-DHAP) for a long chain fatty alcohol, yielding the first ether linked intermediate, i.e. alkyl-dihydroxyacetonephosphate (alkyl-DHAP), in the pathway of ether lipid biosynthesis. {ECO:0000269|PubMed:8399344, ECO:0000269|PubMed:9553082}. |
O00482 | NR5A2 | S243 | psp | Nuclear receptor subfamily 5 group A member 2 (Alpha-1-fetoprotein transcription factor) (B1-binding factor) (hB1F) (CYP7A promoter-binding factor) (Hepatocytic transcription factor) (Liver receptor homolog 1) (LRH-1) | Orphan nuclear receptor that binds DNA as a monomer to the 5'-TCAAGGCCA-3' sequence and controls expression of target genes: regulates key biological processes, such as early embryonic development, cholesterol and bile acid synthesis pathways, as well as liver and pancreas morphogenesis (PubMed:16289203, PubMed:18410128, PubMed:21614002, PubMed:32433991, PubMed:38409506, PubMed:9786908). Ligand-binding causes conformational change which causes recruitment of coactivators, promoting target gene activation (PubMed:21614002). The specific ligand is unknown, but specific phospholipids, such as phosphatidylethanolamine, phosphatidylserine, dilauroyl phosphatidylcholine and diundecanoyl phosphatidylcholine can act as ligand in vitro (PubMed:15707893, PubMed:15723037, PubMed:15897460, PubMed:21614002, PubMed:22504882, PubMed:23737522, PubMed:26416531, PubMed:26553876). Acts as a pioneer transcription factor, which unwraps target DNA from histones and elicits local opening of closed chromatin (PubMed:38409506). Plays a central role during preimplantation stages of embryonic development (By similarity). Plays a minor role in zygotic genome activation (ZGA) by regulating a small set of two-cell stage genes (By similarity). Plays a major role in morula development (2-16 cells embryos) by acting as a master regulator at the 8-cell stage, controlling expression of lineage-specifying transcription factors and genes involved in mitosis, telomere maintenance and DNA repair (By similarity). Zygotic NR5A2 binds to both closed and open chromatin with other transcription factors, often at SINE B1/Alu repeats DNA elements, promoting chromatin accessibility at nearby regulatory regions (By similarity). Also involved in the epiblast stage of development and embryonic stem cell pluripotency, by promoting expression of POU5F1/OCT4 (PubMed:27984042). Regulates other processes later in development, such as formation of connective tissue in lower jaw and middle ear, neural stem cell differentiation, ovarian follicle development and Sertoli cell differentiation (By similarity). Involved in exocrine pancreas development and acinar cell differentiation (By similarity). Acts as an essential transcriptional regulator of lipid metabolism (PubMed:20159957). Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver (PubMed:10359768). Also acts as a negative regulator of inflammation in different organs, such as, liver and pancreas (PubMed:20159957). Protects against intestinal inflammation via its ability to regulate glucocorticoid production (By similarity). Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (PubMed:20159957). Acts as a regulator of immunity by promoting lymphocyte T-cell development, proliferation and effector functions (By similarity). Also involved in resolution of endoplasmic reticulum stress in the liver (By similarity). {ECO:0000250|UniProtKB:P45448, ECO:0000269|PubMed:10359768, ECO:0000269|PubMed:15707893, ECO:0000269|PubMed:15723037, ECO:0000269|PubMed:15897460, ECO:0000269|PubMed:16289203, ECO:0000269|PubMed:18410128, ECO:0000269|PubMed:20159957, ECO:0000269|PubMed:21614002, ECO:0000269|PubMed:22504882, ECO:0000269|PubMed:23737522, ECO:0000269|PubMed:26416531, ECO:0000269|PubMed:26553876, ECO:0000269|PubMed:27984042, ECO:0000269|PubMed:32433991, ECO:0000269|PubMed:38409506, ECO:0000269|PubMed:9786908}.; FUNCTION: [Isoform 3]: In constrast to isoform 1 and isoform 2, does not induce cholesterol 7-alpha-hydroxylase gene (CYP7A) promoter activity. {ECO:0000269|PubMed:10359768}.; FUNCTION: (Microbial infection) Plays a crucial role for hepatitis B virus gene transcription and DNA replication. Mechanistically, synergistically cooperates with HNF1A to up-regulate the activity of one of the critical cis-elements in the hepatitis B virus genome enhancer II (ENII). {ECO:0000269|PubMed:14728801, ECO:0000269|PubMed:9786908}. |
O14686 | KMT2D | S2970 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
O15056 | SYNJ2 | S1443 | ochoa | Synaptojanin-2 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 2) | Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis. |
O15350 | TP73 | S235 | psp | Tumor protein p73 (p53-like transcription factor) (p53-related protein) | Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. Is an activator of FOXJ1 expression (By similarity). It is an essential factor for the positive regulation of lung ciliated cell differentiation (PubMed:34077761). {ECO:0000250|UniProtKB:Q9JJP2, ECO:0000269|PubMed:10203277, ECO:0000269|PubMed:11753569, ECO:0000269|PubMed:18174154, ECO:0000269|PubMed:34077761}. |
O43182 | ARHGAP6 | S711 | ochoa | Rho GTPase-activating protein 6 (Rho-type GTPase-activating protein 6) (Rho-type GTPase-activating protein RhoGAPX-1) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology. {ECO:0000269|PubMed:10699171}. |
O60285 | NUAK1 | S455 | ochoa | NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5) (ARK5) (Omphalocele kinase 1) | Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in DNA damage response: phosphorylates p53/TP53 at 'Ser-15' and 'Ser-392' and is recruited to the CDKN1A/WAF1 promoter to participate in transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with STK11, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (PubMed:25329316). {ECO:0000269|PubMed:12409306, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15060171, ECO:0000269|PubMed:15273717, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:20354225, ECO:0000269|PubMed:21317932, ECO:0000269|PubMed:25329316}. |
O60336 | MAPKBP1 | S1283 | ochoa | Mitogen-activated protein kinase-binding protein 1 (JNK-binding protein 1) (JNKBP-1) | Negative regulator of NOD2 function. It down-regulates NOD2-induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response (PubMed:22700971). Involved in JNK signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q6NS57, ECO:0000269|PubMed:22700971}. |
O75132 | ZBED4 | S617 | ochoa | Zinc finger BED domain-containing protein 4 | Transcriptional regulator that binds to poly-guanine tracts in gene promoters and activates transcription (By similarity). Able to bind single- and double-stranded DNA and RNA (By similarity). {ECO:0000250|UniProtKB:Q80WQ9}. |
O75150 | RNF40 | S114 | psp | E3 ubiquitin-protein ligase BRE1B (BRE1-B) (EC 2.3.2.27) (95 kDa retinoblastoma-associated protein) (RBP95) (RING finger protein 40) (RING-type E3 ubiquitin transferase BRE1B) | Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. {ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:19410543}.; FUNCTION: (Microbial infection) Promotes the human herpesvirus 8 (KSHV) lytic cycle by inducing the expression of lytic viral genes including the latency switch gene RTA/ORF50. {ECO:0000269|PubMed:37888983}. |
O75153 | CLUH | S649 | ochoa | Clustered mitochondria protein homolog | mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. Specifically binds mRNAs of nuclear-encoded mitochondrial proteins in the cytoplasm and regulates transport or translation of these transcripts close to mitochondria, playing a role in mitochondrial biogenesis. {ECO:0000255|HAMAP-Rule:MF_03013, ECO:0000269|PubMed:25349259}. |
O75385 | ULK1 | S716 | ochoa | Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1) | Serine/threonine-protein kinase involved in autophagy in response to starvation (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:23524951, PubMed:25040165, PubMed:29487085, PubMed:31123703). Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165). Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR (PubMed:21795849). Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity (PubMed:21460634). May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences (PubMed:18936157). Plays a role early in neuronal differentiation and is required for granule cell axon formation (PubMed:11146101). Also phosphorylates SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165, PubMed:37306101). Phosphorylates FLCN, promoting autophagy (PubMed:25126726). Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation (PubMed:20921139). Phosphorylates ATG4B, leading to inhibit autophagy by decreasing both proteolytic activation and delipidation activities of ATG4B (PubMed:28821708). {ECO:0000269|PubMed:11146101, ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:20921139, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:25040165, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:28821708, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:31123703, ECO:0000269|PubMed:37306101}. |
O94806 | PRKD3 | S391 | ochoa | Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (Protein kinase EPK2) (nPKC-nu) | Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity). {ECO:0000250}. |
O94886 | TMEM63A | S739 | ochoa | Mechanosensitive cation channel TMEM63A (Transmembrane protein 63A) (hTMEM63A) | Mechanosensitive cation channel with low conductance and high activation threshold (PubMed:30382938, PubMed:31587869, PubMed:37543036). In contrast to TMEM63B, does not show phospholipid scramblase activity (PubMed:39716028). Acts as a regulator of lysosomal morphology by mediating lysosomal mechanosensitivity (By similarity). Important for the baby's first breath and respiration throughout life (PubMed:38127458). Upon lung inflation conducts cation currents in alveolar type 1 and 2 cells triggering lamellar body exocytosis and surfactant secretion into airspace (PubMed:38127458). Also acts as an osmosensitive cation channel preferentially activated by hypotonic stress (By similarity). {ECO:0000250|UniProtKB:Q91YT8, ECO:0000269|PubMed:30382938, ECO:0000269|PubMed:31587869, ECO:0000269|PubMed:37543036, ECO:0000269|PubMed:38127458, ECO:0000269|PubMed:39716028}. |
O94913 | PCF11 | S645 | ochoa | Pre-mRNA cleavage complex 2 protein Pcf11 (Pre-mRNA cleavage complex II protein Pcf11) | Component of pre-mRNA cleavage complex II, which promotes transcription termination by RNA polymerase II. {ECO:0000269|PubMed:11060040, ECO:0000269|PubMed:29196535}. |
O94979 | SEC31A | S251 | ochoa | Protein transport protein Sec31A (ABP125) (ABP130) (SEC31-like protein 1) (SEC31-related protein A) (Web1-like protein) | Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER) (PubMed:10788476). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). {ECO:0000250|UniProtKB:Q9Z2Q1, ECO:0000269|PubMed:10788476}. |
O94992 | HEXIM1 | S98 | ochoa | Protein HEXIM1 (Cardiac lineage protein 1) (Estrogen down-regulated gene 1 protein) (Hexamethylene bis-acetamide-inducible protein 1) (Menage a quatre protein 1) | Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:14580347, PubMed:15201869, PubMed:15713661). Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:12832472, PubMed:14580347, PubMed:15201869, PubMed:15713661). May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity (PubMed:15940264, PubMed:15941832, PubMed:17088550). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000269|PubMed:12581153, ECO:0000269|PubMed:12832472, ECO:0000269|PubMed:14580347, ECO:0000269|PubMed:15201869, ECO:0000269|PubMed:15713661, ECO:0000269|PubMed:15940264, ECO:0000269|PubMed:15941832, ECO:0000269|PubMed:17088550, ECO:0000269|PubMed:28712728}. |
O95359 | TACC2 | S1562 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
O96013 | PAK4 | S97 | ochoa | Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4) | Serine/threonine-protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell adhesion turnover, cell migration, growth, proliferation or cell survival (PubMed:26598620). Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN. Promotes kinase-independent stabilization of RHOU, thereby contributing to focal adhesion disassembly during cell migration (PubMed:26598620). {ECO:0000269|PubMed:11278822, ECO:0000269|PubMed:11313478, ECO:0000269|PubMed:14560027, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:20507994, ECO:0000269|PubMed:20631255, ECO:0000269|PubMed:20805321, ECO:0000269|PubMed:26598620, ECO:0000269|PubMed:26607847}. |
O96013 | PAK4 | S99 | ochoa|psp | Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4) | Serine/threonine-protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell adhesion turnover, cell migration, growth, proliferation or cell survival (PubMed:26598620). Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN. Promotes kinase-independent stabilization of RHOU, thereby contributing to focal adhesion disassembly during cell migration (PubMed:26598620). {ECO:0000269|PubMed:11278822, ECO:0000269|PubMed:11313478, ECO:0000269|PubMed:14560027, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:20507994, ECO:0000269|PubMed:20631255, ECO:0000269|PubMed:20805321, ECO:0000269|PubMed:26598620, ECO:0000269|PubMed:26607847}. |
P01275 | GCG | S36 | ochoa | Pro-glucagon [Cleaved into: Glicentin; Glicentin-related polypeptide (GRPP); Oxyntomodulin (OXM) (OXY); Glucagon; Glucagon-like peptide 1 (GLP-1) (Incretin hormone); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)] | [Glucagon]: Plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes. {ECO:0000305|PubMed:10605628, ECO:0000305|PubMed:12626323}.; FUNCTION: [Glucagon-like peptide 1]: Potent stimulator of glucose-dependent insulin release. Also stimulates insulin release in response to IL6 (PubMed:22037645). Plays important roles on gastric motility and the suppression of plasma glucagon levels. May be involved in the suppression of satiety and stimulation of glucose disposal in peripheral tissues, independent of the actions of insulin. Has growth-promoting activities on intestinal epithelium. May also regulate the hypothalamic pituitary axis (HPA) via effects on LH, TSH, CRH, oxytocin, and vasopressin secretion. Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferation. Inhibits beta cell apoptosis (Probable). {ECO:0000269|PubMed:22037645, ECO:0000305|PubMed:10605628, ECO:0000305|PubMed:12554744, ECO:0000305|PubMed:14719035}.; FUNCTION: [Glucagon-like peptide 2]: Stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a key role in nutrient homeostasis, enhancing nutrient assimilation through enhanced gastrointestinal function, as well as increasing nutrient disposal. Stimulates intestinal glucose transport and decreases mucosal permeability. {ECO:0000305|PubMed:10322410, ECO:0000305|PubMed:10605628, ECO:0000305|PubMed:12554744, ECO:0000305|PubMed:14719035}.; FUNCTION: [Oxyntomodulin]: Significantly reduces food intake. Inhibits gastric emptying in humans. Suppression of gastric emptying may lead to increased gastric distension, which may contribute to satiety by causing a sensation of fullness. {ECO:0000305|PubMed:10605628, ECO:0000305|PubMed:12554744}.; FUNCTION: [Glicentin]: May modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life. {ECO:0000305|PubMed:10605628, ECO:0000305|PubMed:12554744}. |
P05106 | ITGB3 | S103 | ochoa | Integrin beta-3 (Platelet membrane glycoprotein IIIa) (GPIIIa) (CD antigen CD61) | Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain (By similarity). Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen (PubMed:9111081). This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and acts as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415, PubMed:24789099). ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (PubMed:18441324). ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling (PubMed:28302677). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:19578119). ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling (PubMed:29030430). ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGAV:ITGB3 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887). In brain, plays a role in synaptic transmission and plasticity. Involved in the regulation of the serotonin neurotransmission, is required to localize to specific compartments within the synapse the serotonin receptor SLC6A4 and for an appropriate reuptake of serotonin. Controls excitatory synaptic strength by regulating GRIA2-containing AMPAR endocytosis, which affects AMPAR abundance and composition (By similarity). ITGAV:ITGB3 act as a receptor for CD40LG (PubMed:31331973). ITGAV:ITGB3 acts as a receptor for IBSP and promotes cell adhesion and migration to IBSP (PubMed:10640428). {ECO:0000250|UniProtKB:O54890, ECO:0000269|PubMed:10640428, ECO:0000269|PubMed:12807887, ECO:0000269|PubMed:18441324, ECO:0000269|PubMed:18635536, ECO:0000269|PubMed:19578119, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:23125415, ECO:0000269|PubMed:24789099, ECO:0000269|PubMed:25398877, ECO:0000269|PubMed:28302677, ECO:0000269|PubMed:28873464, ECO:0000269|PubMed:29030430, ECO:0000269|PubMed:31331973, ECO:0000269|PubMed:9111081, ECO:0000269|PubMed:9195946, ECO:0000303|PubMed:16322781, ECO:0000303|PubMed:17635696}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Herpes virus 8/HHV-8. {ECO:0000269|PubMed:18045938}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Coxsackievirus A9. {ECO:0000269|PubMed:7519807}.; FUNCTION: (Microbial infection) Acts as a receptor for Hantaan virus. {ECO:0000269|PubMed:9618541}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Cytomegalovirus/HHV-5. {ECO:0000269|PubMed:15834425}.; FUNCTION: (Microbial infection) Integrin ITGA5:ITGB3 acts as a receptor for Human metapneumovirus. {ECO:0000269|PubMed:24478423}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts aP05556s a receptor for Human parechovirus 1. {ECO:0000269|PubMed:11160695}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for West nile virus. {ECO:0000269|PubMed:23658209}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. {ECO:0000269|PubMed:10397733}. |
P07355 | ANXA2 | S26 | ochoa|psp | Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:22848640, PubMed:24808179). Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation (By similarity). Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis (By similarity). {ECO:0000250|UniProtKB:P07356, ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22848640, ECO:0000269|PubMed:24808179}.; FUNCTION: (Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen. {ECO:0000269|PubMed:25139904}. |
P07900 | HSP90AA1 | S709 | ochoa | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}. |
P07954 | FH | S366 | ochoa | Fumarate hydratase, mitochondrial (Fumarase) (HsFH) (EC 4.2.1.2) | Catalyzes the reversible stereospecific interconversion of fumarate to L-malate (PubMed:30761759). Experiments in other species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable). {ECO:0000269|PubMed:30761759, ECO:0000305}.; FUNCTION: [Isoform Mitochondrial]: Catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH. {ECO:0000250|UniProtKB:P10173}.; FUNCTION: [Isoform Cytoplasmic]: Catalyzes the dehydration of L-malate to fumarate (By similarity). Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism (By similarity). Also plays a role in DNA repair by promoting non-homologous end-joining (NHEJ) (PubMed:20231875, PubMed:26237645). In response to DNA damage and phosphorylation by PRKDC, translocates to the nucleus and accumulates at DNA double-strand breaks (DSBs): acts by catalyzing formation of fumarate, an inhibitor of KDM2B histone demethylase activity, resulting in enhanced dimethylation of histone H3 'Lys-36' (H3K36me2) (PubMed:26237645). {ECO:0000250|UniProtKB:P97807, ECO:0000269|PubMed:20231875, ECO:0000269|PubMed:26237645}. |
P08047 | SP1 | S732 | psp | Transcription factor Sp1 | Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Also binds the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component BMAL1 (PubMed:10391891, PubMed:11371615, PubMed:11904305, PubMed:14593115, PubMed:16377629, PubMed:16478997, PubMed:16943418, PubMed:17049555, PubMed:18171990, PubMed:18199680, PubMed:18239466, PubMed:18513490, PubMed:18619531, PubMed:19193796, PubMed:20091743, PubMed:21046154, PubMed:21798247). Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays a role in protecting cells against oxidative stress following brain injury by regulating the expression of RNF112 (By similarity). {ECO:0000250|UniProtKB:O89090, ECO:0000250|UniProtKB:Q01714, ECO:0000269|PubMed:10391891, ECO:0000269|PubMed:11371615, ECO:0000269|PubMed:11904305, ECO:0000269|PubMed:14593115, ECO:0000269|PubMed:16377629, ECO:0000269|PubMed:16478997, ECO:0000269|PubMed:16943418, ECO:0000269|PubMed:17049555, ECO:0000269|PubMed:18171990, ECO:0000269|PubMed:18199680, ECO:0000269|PubMed:18239466, ECO:0000269|PubMed:18513490, ECO:0000269|PubMed:18619531, ECO:0000269|PubMed:19193796, ECO:0000269|PubMed:20091743, ECO:0000269|PubMed:21046154, ECO:0000269|PubMed:21798247}. |
P12270 | TPR | S646 | ochoa | Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:11952838, PubMed:22253824). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:21613532, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:9864356}. |
P12724 | RNASE3 | S121 | ochoa | Eosinophil cationic protein (ECP) (EC 3.1.27.-) (Ribonuclease 3) (RNase 3) | Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content. {ECO:0000269|PubMed:19450231, ECO:0000269|PubMed:2501794}. |
P13994 | YJU2B | S306 | ochoa | Probable splicing factor YJU2B (Coiled-coil domain-containing protein 130) | May be involved in mRNA splicing. {ECO:0000250|UniProtKB:Q9BW85}. |
P14923 | JUP | S475 | ochoa | Junction plakoglobin (Catenin gamma) (Desmoplakin III) (Desmoplakin-3) | Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity). {ECO:0000250}. |
P16104 | H2AX | S122 | ochoa | Histone H2AX (H2a/x) (Histone H2A.X) | Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation. {ECO:0000269|PubMed:10959836, ECO:0000269|PubMed:12419185, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:17709392, ECO:0000269|PubMed:26438602}. |
P18583 | SON | S182 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
P21127 | CDK11B | S589 | ochoa | Cyclin-dependent kinase 11B (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 1) (CLK-1) (Cell division protein kinase 11B) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L1) (p58 CLK-1) | Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression. {ECO:0000269|PubMed:12501247, ECO:0000269|PubMed:12624090, ECO:0000269|PubMed:18216018, ECO:0000269|PubMed:2217177}. |
P23258 | TUBG1 | S80 | ochoa|psp | Tubulin gamma-1 chain (Gamma-1-tubulin) (Gamma-tubulin complex component 1) (GCP-1) | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:38609661, PubMed:39321809). Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:38305685, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685, PubMed:38609661, PubMed:39321809). {ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
P23588 | EIF4B | S459 | ochoa | Eukaryotic translation initiation factor 4B (eIF-4B) | Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. |
P27816 | MAP4 | S329 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
P27987 | ITPKB | S355 | ochoa | Inositol-trisphosphate 3-kinase B (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase B) (IP3 3-kinase B) (IP3K B) (InsP 3-kinase B) | Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis. {ECO:0000269|PubMed:11846419, ECO:0000269|PubMed:12747803, ECO:0000269|PubMed:1654894}. |
P28360 | MSX1 | S136 | ochoa | Homeobox protein MSX-1 (Homeobox protein Hox-7) (Msh homeobox 1-like protein) | Acts as a transcriptional repressor (By similarity). Capable of transcription autoinactivation (By similarity). Binds to the consensus sequence 5'-C/GTAAT-3' in downstream activin regulatory elements (DARE) in the gene promoter, thereby repressing the transcription of CGA/alpha-GSU and GNRHR (By similarity). Represses transcription of myoblast differentiation factors (By similarity). Binds to core enhancer regions in target gene promoters of myoblast differentiation factors with binding specificity facilitated by interaction with PIAS1 (By similarity). Regulates, in a stage-specific manner, a developmental program of gene expression in the fetal tooth bud that controls odontoblast differentiation and proliferation of dental mesenchymal cells (By similarity). At the bud stage, required for mesenchymal molar tooth bud development via facilitating reciprocal signaling between dental epithelial and mesenchymal cells (By similarity). May also regulate expression of Wnt antagonists such as DKK2 and SFPR2 in the developing tooth mesenchyme (By similarity). Required for BMP4 expression in dental mesenchyme cells (By similarity). Also, in response to BMP4, required for BMP4 expression in neighboring dental epithelial cells (By similarity). Required for maximal FGF4-induced expression of SDC1 in dental mesenchyme cells (By similarity). Also in response to SDC1, required for SDC1 expression in neighboring dental epithelial cells (By similarity). At the early bell stage, acts to drive proliferation of dental mesenchyme cells, however during the late bell stage acts as an homeostatic regulator of the cell cycle (By similarity). Regulates proliferation and inhibits premature mesenchymal odontogenesis during the bell stage via inhibition of the Wnt signaling component CTNNB1 and subsequent repression of the odontoblast differentiation factors BMP2, BMP4, LEF1, ALPL and BGLAP/OCN (By similarity). Additionally, required for correct development and fusion of the palatal shelves and embryonic mandibular formation (By similarity). Plays a role in embryonic bone formation of the middle ear, skull and nasal bones (By similarity). Required for correct formation and thickness of the nail plate (By similarity). May play a role in limb-pattern formation (By similarity). {ECO:0000250|UniProtKB:P13297, ECO:0000269|PubMed:12807959, ECO:0000303|PubMed:8696335}. |
P29401 | TKT | S105 | ochoa | Transketolase (TK) (EC 2.2.1.1) | Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. {ECO:0000269|PubMed:27259054}. |
P34741 | SDC2 | S178 | ochoa | Syndecan-2 (SYND2) (Fibroglycan) (Heparan sulfate proteoglycan core protein) (HSPG) (CD antigen CD362) | Cell surface proteoglycan which regulates dendritic arbor morphogenesis. {ECO:0000250|UniProtKB:P43407}. |
P38398 | BRCA1 | S1577 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
P41440 | SLC19A1 | S515 | ochoa | Reduced folate transporter (FOLT) (Cyclic dinucleotide:anion antiporter SLC19A1) (Folate:anion antiporter SLC19A1) (Intestinal folate carrier 1) (IFC-1) (Placental folate transporter) (Reduced folate carrier protein) (RFC) (hRFC) (Reduced folate transporter 1) (RFT-1) (Solute carrier family 19 member 1) (hSLC19A1) | Antiporter that mediates the import of reduced folates or a subset of cyclic dinucleotides, driven by the export of organic anions (PubMed:10787414, PubMed:15337749, PubMed:16115875, PubMed:22554803, PubMed:31126740, PubMed:31511694, PubMed:32276275, PubMed:36071163, PubMed:36265513, PubMed:36575193, PubMed:7826387, PubMed:9041240). Acts as an importer of immunoreactive cyclic dinucleotides, such as cyclic GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol, and its linkage isomer 3'-3'-cGAMP, thus playing a role in triggering larger immune responses (PubMed:31126740, PubMed:31511694, PubMed:36745868). Mechanistically, acts as a secondary active transporter, which exports intracellular organic anions down their concentration gradients to facilitate the uptake of its substrates (PubMed:22554803, PubMed:31126740, PubMed:31511694). Has high affinity for N5-methyltetrahydrofolate, the predominant circulating form of folate (PubMed:10787414, PubMed:14609557, PubMed:22554803, PubMed:36071163, PubMed:36265513, PubMed:36575193). Also mediates the import of antifolate drug methotrexate (PubMed:22554803, PubMed:36071163, PubMed:7615551, PubMed:7641195, PubMed:9767079). 5-amino-4-imidazolecarboxamide riboside (AICAR), when phosphorylated to AICAR monophosphate, can serve as an organic anion for antiporter activity (PubMed:22554803). {ECO:0000269|PubMed:10787414, ECO:0000269|PubMed:14609557, ECO:0000269|PubMed:15337749, ECO:0000269|PubMed:16115875, ECO:0000269|PubMed:22554803, ECO:0000269|PubMed:31126740, ECO:0000269|PubMed:31511694, ECO:0000269|PubMed:32276275, ECO:0000269|PubMed:36071163, ECO:0000269|PubMed:36265513, ECO:0000269|PubMed:36575193, ECO:0000269|PubMed:36745868, ECO:0000269|PubMed:7615551, ECO:0000269|PubMed:7641195, ECO:0000269|PubMed:7826387, ECO:0000269|PubMed:9041240, ECO:0000269|PubMed:9767079}. |
P46087 | NOP2 | S674 | ochoa | 28S rRNA (cytosine(4447)-C(5))-methyltransferase (EC 2.1.1.-) (Nucleolar protein 1) (Nucleolar protein 2 homolog) (Proliferating-cell nucleolar antigen p120) (Proliferation-associated nucleolar protein p120) | S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (PubMed:26196125). Required for efficient rRNA processing and 60S ribosomal subunit biogenesis (PubMed:24120868, PubMed:36161484). Regulates pre-rRNA processing through non-catalytic complex formation with box C/D snoRNAs and facilitates the recruitment of U3 and U8 snoRNAs to pre-90S ribosomal particles and their stable assembly into snoRNP complexes (PubMed:36161484). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (PubMed:24120868). {ECO:0000269|PubMed:24120868, ECO:0000269|PubMed:26196125, ECO:0000269|PubMed:36161484}. |
P46527 | CDKN1B | S83 | psp | Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1) | Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA (PubMed:28666995). Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. {ECO:0000269|PubMed:10831586, ECO:0000269|PubMed:12244301, ECO:0000269|PubMed:16782892, ECO:0000269|PubMed:17254966, ECO:0000269|PubMed:19075005, ECO:0000269|PubMed:28666995}. |
P46939 | UTRN | S3297 | ochoa | Utrophin (Dystrophin-related protein 1) (DRP-1) | May play a role in anchoring the cytoskeleton to the plasma membrane. {ECO:0000250}. |
P49588 | AARS1 | S399 | ochoa | Alanine--tRNA ligase, cytoplasmic (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS) (Protein lactyltransferase AARS1) (EC 6.-.-.-) (Renal carcinoma antigen NY-REN-42) | Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala) (PubMed:27622773, PubMed:27911835, PubMed:28493438, PubMed:33909043). Also edits incorrectly charged tRNA(Ala) via its editing domain (PubMed:27622773, PubMed:27911835, PubMed:28493438, PubMed:29273753). In presence of high levels of lactate, also acts as a protein lactyltransferase that mediates lactylation of lysine residues in target proteins, such as TEAD1, TP53/p53 and YAP1 (PubMed:38512451, PubMed:38653238). Protein lactylation takes place in a two-step reaction: lactate is first activated by ATP to form lactate-AMP and then transferred to lysine residues of target proteins (PubMed:38512451, PubMed:38653238, PubMed:39322678). Acts as an inhibitor of TP53/p53 activity by catalyzing lactylation of TP53/p53 (PubMed:38653238). Acts as a positive regulator of the Hippo pathway by mediating lactylation of TEAD1 and YAP1 (PubMed:38512451). {ECO:0000269|PubMed:27622773, ECO:0000269|PubMed:27911835, ECO:0000269|PubMed:28493438, ECO:0000269|PubMed:29273753, ECO:0000269|PubMed:33909043, ECO:0000269|PubMed:38512451, ECO:0000269|PubMed:38653238, ECO:0000269|PubMed:39322678}. |
P50548 | ERF | S327 | ochoa | ETS domain-containing transcription factor ERF (Ets2 repressor factor) (PE-2) | Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment (By similarity). May be important for regulating trophoblast stem cell differentiation (By similarity). {ECO:0000250}. |
P50570 | DNM2 | S742 | ochoa | Dynamin-2 (EC 3.6.5.5) (Dynamin 2) (Dynamin II) | Catalyzes the hydrolysis of GTP and utilizes this energy to mediate vesicle scission at plasma membrane during endocytosis and filament remodeling at many actin structures during organization of the actin cytoskeleton (PubMed:15731758, PubMed:19605363, PubMed:19623537, PubMed:33713620, PubMed:34744632). Plays an important role in vesicular trafficking processes, namely clathrin-mediated endocytosis (CME), exocytic and clathrin-coated vesicle from the trans-Golgi network, and PDGF stimulated macropinocytosis (PubMed:15731758, PubMed:19623537, PubMed:33713620). During vesicular trafficking process, associates to the membrane, through lipid binding, and self-assembles into ring-like structure through oligomerization to form a helical polymer around the vesicle membrane and leading to vesicle scission (PubMed:17636067, PubMed:34744632, PubMed:36445308). Plays a role in organization of the actin cytoskeleton by mediating arrangement of stress fibers and actin bundles in podocytes (By similarity). During organization of the actin cytoskeleton, self-assembles into ring-like structure that directly bundles actin filaments to form typical membrane tubules decorated with dynamin spiral polymers (By similarity). Self-assembly increases GTPase activity and the GTP hydrolysis causes the rapid depolymerization of dynamin spiral polymers, and results in dispersion of actin bundles (By similarity). Remodels, through its interaction with CTTN, bundled actin filaments in a GTPase-dependent manner and plays a role in orchestrating the global actomyosin cytoskeleton (PubMed:19605363). The interaction with CTTN stabilizes the interaction of DNM2 and actin filaments and stimulates the intrinsic GTPase activity that results in actin filament-barbed ends and increases the sensitivity of filaments in bundles to the actin depolymerizing factor, CFL1 (By similarity). Plays a role in the autophagy process, by participating in the formation of ATG9A vesicles destined for the autophagosomes through its interaction with SNX18 (PubMed:29437695), by mediating recycling endosome scission leading to autophagosome release through MAP1LC3B interaction (PubMed:29437695, PubMed:32315611). Also regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (By similarity). Also plays a role in cytokinesis (By similarity). May participate in centrosome cohesion through its interaction with TUBG1 (By similarity). Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Involved in membrane tubulation (PubMed:24135484). {ECO:0000250|UniProtKB:P39052, ECO:0000250|UniProtKB:P39054, ECO:0000269|PubMed:15731758, ECO:0000269|PubMed:17636067, ECO:0000269|PubMed:19605363, ECO:0000269|PubMed:19623537, ECO:0000269|PubMed:24135484, ECO:0000269|PubMed:29437695, ECO:0000269|PubMed:32315611, ECO:0000269|PubMed:33713620, ECO:0000269|PubMed:34744632, ECO:0000269|PubMed:36445308}. |
P50613 | CDK7 | S164 | ochoa|psp | Cyclin-dependent kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (39 kDa protein kinase) (p39 Mo15) (CDK-activating kinase 1) (Cell division protein kinase 7) (Serine/threonine-protein kinase 1) (TFIIH basal transcription factor complex kinase subunit) | Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription (PubMed:9852112, PubMed:19136461, PubMed:26257281, PubMed:28768201). Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201). Initiates transcription by RNA polymerase II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, PubMed:28768201). CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the CTD of POLR2A, allowing its escape from the promoter and elongation of the transcripts (PubMed:9852112). Its expression and activity are constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 activation by phosphorylation, but is inactivated in turn by p53/TP53; this feedback loop may lead to an arrest of the cell cycle and of the transcription, helping in cell recovery, or to apoptosis. Required for DNA-bound peptides-mediated transcription and cellular growth inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, ECO:0000269|PubMed:9372954, ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
P51582 | P2RY4 | S333 | psp | P2Y purinoceptor 4 (P2Y4) (P2P) (Uridine nucleotide receptor) (UNR) | Receptor for UTP and UDP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. Not activated by ATP or ADP. |
P54253 | ATXN1 | S82 | ochoa | Ataxin-1 (Spinocerebellar ataxia type 1 protein) | Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism (PubMed:21475249). In concert with CIC and ATXN1L, involved in brain development (By similarity). {ECO:0000250|UniProtKB:P54254, ECO:0000269|PubMed:21475249}. |
P56192 | MARS1 | S662 | psp | Methionine--tRNA ligase, cytoplasmic (EC 6.1.1.10) (Methionyl-tRNA synthetase) (MetRS) | Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA (PubMed:11714285). Plays a role in the synthesis of ribosomal RNA in the nucleolus (PubMed:10791971). {ECO:0000269|PubMed:10791971, ECO:0000269|PubMed:11714285, ECO:0000269|PubMed:33909043}. |
P61244 | MAX | S108 | ochoa | Protein max (Class D basic helix-loop-helix protein 4) (bHLHd4) (Myc-associated factor X) | Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements. {ECO:0000269|PubMed:26070438}. |
P62714 | PPP2CB | S43 | ochoa | Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PP2A-beta) (EC 3.1.3.16) | Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events (Probable). PP2A can modulate the activity of phosphorylase B kinase, casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:2555176, ECO:0000305}. |
Q00534 | CDK6 | S290 | ochoa | Cyclin-dependent kinase 6 (EC 2.7.11.22) (Cell division protein kinase 6) (Serine/threonine-protein kinase PLSTIRE) | Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and negatively regulates cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. May play a role in the centrosome organization during the cell cycle phases (PubMed:23918663). {ECO:0000269|PubMed:12833137, ECO:0000269|PubMed:14985467, ECO:0000269|PubMed:15254224, ECO:0000269|PubMed:15809340, ECO:0000269|PubMed:17420273, ECO:0000269|PubMed:17431401, ECO:0000269|PubMed:20333249, ECO:0000269|PubMed:20668294, ECO:0000269|PubMed:23918663, ECO:0000269|PubMed:8114739}. |
Q00978 | IRF9 | S252 | psp | Interferon regulatory factor 9 (IRF-9) (IFN-alpha-responsive transcription factor subunit) (ISGF3 p48 subunit) (Interferon-stimulated gene factor 3 gamma) (ISGF-3 gamma) (Transcriptional regulator ISGF3 subunit gamma) | Transcription factor that plays an essential role in anti-viral immunity. It mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. {ECO:0000269|PubMed:30143481}. |
Q01804 | OTUD4 | S905 | ochoa | OTU domain-containing protein 4 (EC 3.4.19.12) (HIV-1-induced protein HIN-1) | Deubiquitinase which hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein (PubMed:23827681, PubMed:25944111, PubMed:29395066). May negatively regulate inflammatory and pathogen recognition signaling in innate immune response. Upon phosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptor and Toll-like receptor signaling pathway, specifically deubiquitinates 'Lys-63'-polyubiquitinated MYD88 adapter protein triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators (PubMed:29395066). Independently of the catalytic activity, acts as a scaffold for alternative deubiquitinases to assemble specific deubiquitinase-substrate complexes. Associates with USP7 and USP9X deubiquitinases to stabilize alkylation repair enzyme ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111). {ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:25944111, ECO:0000269|PubMed:29395066}. |
Q02241 | KIF23 | S911 | ochoa|psp | Kinesin-like protein KIF23 (Kinesin-like protein 5) (Mitotic kinesin-like protein 1) | Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro. {ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:22522702, ECO:0000269|PubMed:23570799}. |
Q04637 | EIF4G1 | S1097 | ochoa | Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:29987188). Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) (PubMed:29987188). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon (PubMed:29987188). Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning (PubMed:29987188). As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). {ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29987188}. |
Q04725 | TLE2 | S307 | ochoa | Transducin-like enhancer protein 2 (Enhancer of split groucho-like protein 2) (ESG2) | Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). {ECO:0000250}. |
Q06413 | MEF2C | S183 | ochoa | Myocyte-specific enhancer factor 2C (Myocyte enhancer factor 2C) | Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoforms that lack the repressor domain are more active than isoform 1. {ECO:0000250|UniProtKB:Q8CFN5, ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:15340086, ECO:0000269|PubMed:15831463, ECO:0000269|PubMed:15834131, ECO:0000269|PubMed:9069290, ECO:0000269|PubMed:9384584}. |
Q07889 | SOS1 | S1286 | ochoa | Son of sevenless homolog 1 (SOS-1) | Promotes the exchange of Ras-bound GDP by GTP (PubMed:8493579). Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3/ERK1 in response to EGF (PubMed:17339331). Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity). {ECO:0000250|UniProtKB:Q62245, ECO:0000269|PubMed:17339331, ECO:0000269|PubMed:8493579}. |
Q08AE8 | SPIRE1 | S735 | ochoa | Protein spire homolog 1 (Spir-1) | Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed:11747823, PubMed:21620703). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (PubMed:11747823). Required for asymmetric spindle positioning and asymmetric cell division during meiosis (PubMed:21620703). Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703). Also acts in the nucleus: together with FMN2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). In addition, promotes innate immune signaling downstream of dsRNA sensing (PubMed:35148361). Mechanistically, contributes to IRF3 phosphorylation and activation downstream of MAVS and upstream of TBK1 (PubMed:35148361). {ECO:0000269|PubMed:11747823, ECO:0000269|PubMed:21620703, ECO:0000269|PubMed:26287480, ECO:0000269|PubMed:35148361}. |
Q0JRZ9 | FCHO2 | S387 | ochoa | F-BAR domain only protein 2 | Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor. {ECO:0000269|PubMed:17540576, ECO:0000269|PubMed:20448150, ECO:0000269|PubMed:21762413, ECO:0000269|PubMed:22323290}. |
Q12815 | TROAP | S408 | ochoa | Tastin (Trophinin-assisting protein) (Trophinin-associated protein) | Could be involved with bystin and trophinin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation. |
Q12834 | CDC20 | S161 | psp | Cell division cycle protein 20 homolog (p55CDC) | Substrate-specific adapter of the anaphase promoting complex/cyclosome (APC/C) complex that confers substrate specificity by binding to substrates and targeting them to the APC/C complex for ubiquitination and degradation (PubMed:9734353, PubMed:27030811, PubMed:29343641). Recognizes and binds the destruction box (D box) on protein substrates (PubMed:29343641). Involved in the metaphase/anaphase transition of cell cycle (PubMed:32666501). Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates (PubMed:9811605, PubMed:9637688). The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons (By similarity). CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation (By similarity). The CDC20-APC/C complex promotes proper dilation formation and radial migration by degrading CCDC41 (By similarity). {ECO:0000250|UniProtKB:Q9JJ66, ECO:0000269|PubMed:27030811, ECO:0000269|PubMed:29343641, ECO:0000269|PubMed:32666501, ECO:0000269|PubMed:9637688, ECO:0000269|PubMed:9734353, ECO:0000269|PubMed:9811605}. |
Q12923 | PTPN13 | S217 | ochoa | Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1) (PTP-BAS) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (Protein-tyrosine phosphatase PTPL1) | Tyrosine phosphatase which negatively regulates FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317). {ECO:0000269|PubMed:15611135, ECO:0000269|PubMed:23604317}. |
Q13164 | MAPK7 | S496 | psp | Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5) | Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via interaction with STUB1/CHIP and promotion of STUB1-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity). May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction. {ECO:0000250|UniProtKB:P0C865, ECO:0000269|PubMed:11254654, ECO:0000269|PubMed:11278431, ECO:0000269|PubMed:22869143, ECO:0000269|PubMed:9384584, ECO:0000269|PubMed:9790194}. |
Q13469 | NFATC2 | S148 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1) | Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF (PubMed:15790681). Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway (PubMed:21871017). Is involved in the negative regulation of chondrogenesis (PubMed:35789258). Recruited by AKAP5 to ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where store-operated Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses. {ECO:0000250|UniProtKB:Q60591, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:21871017, ECO:0000269|PubMed:35789258}. |
Q13568 | IRF5 | S440 | psp | Interferon regulatory factor 5 (IRF-5) | Transcription factor that plays a critical role in innate immunity by activating expression of type I interferon (IFN) IFNA and INFB and inflammatory cytokines downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9 (PubMed:11303025, PubMed:15695821, PubMed:22412986, PubMed:25326418, PubMed:32433612). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (By similarity). Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction downstream of the TLR-activated, MyD88-dependent pathway (By similarity). Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000250|UniProtKB:P56477, ECO:0000269|PubMed:11303025, ECO:0000269|PubMed:15695821, ECO:0000269|PubMed:22412986, ECO:0000269|PubMed:25326418, ECO:0000269|PubMed:32433612, ECO:0000269|PubMed:33440148}. |
Q13615 | MTMR3 | S735 | ochoa | Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3 (EC 3.1.3.95) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Myotubularin-related protein 3) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (Phosphatidylinositol-3-phosphate phosphatase) (Zinc finger FYVE domain-containing protein 10) | Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate (PubMed:10733931, PubMed:11302699, PubMed:11676921, PubMed:12646134). Decreases the levels of phosphatidylinositol 3-phosphate, a phospholipid found in cell membranes where it acts as key regulator of both cell signaling and intracellular membrane traffic (PubMed:11302699, PubMed:11676921, PubMed:12646134). Could also have a molecular sequestering/adapter activity and regulate biological processes independently of its phosphatase activity. It includes the regulation of midbody abscission during mitotic cytokinesis (PubMed:25659891). {ECO:0000269|PubMed:10733931, ECO:0000269|PubMed:11302699, ECO:0000269|PubMed:11676921, ECO:0000269|PubMed:12646134, ECO:0000269|PubMed:25659891}. |
Q13950 | RUNX2 | S247 | ochoa|psp | Runt-related transcription factor 2 (Acute myeloid leukemia 3 protein) (Core-binding factor subunit alpha-1) (CBF-alpha-1) (Oncogene AML-3) (Osteoblast-specific transcription factor 2) (OSF-2) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEA2-alpha A) (PEBP2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit) | Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis (PubMed:28505335, PubMed:28703881, PubMed:28738062). Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation. {ECO:0000250, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:28505335, ECO:0000269|PubMed:28703881, ECO:0000269|PubMed:28738062}. |
Q14524 | SCN5A | S1934 | psp | Sodium channel protein type 5 subunit alpha (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (hH1) | Pore-forming subunit of Nav1.5, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:1309946, PubMed:21447824, PubMed:23085483, PubMed:23420830, PubMed:25370050, PubMed:26279430, PubMed:26392562, PubMed:26776555). Nav1.5 is the predominant sodium channel expressed in myocardial cells and it is responsible for the initial upstroke of the action potential in cardiac myocytes, thereby initiating the heartbeat (PubMed:11234013, PubMed:11804990, PubMed:12569159, PubMed:1309946). Required for normal electrical conduction including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with XIRP2 (By similarity). {ECO:0000250|UniProtKB:Q9JJV9, ECO:0000269|PubMed:11234013, ECO:0000269|PubMed:11804990, ECO:0000269|PubMed:12569159, ECO:0000269|PubMed:1309946, ECO:0000269|PubMed:19074138, ECO:0000269|PubMed:21447824, ECO:0000269|PubMed:23085483, ECO:0000269|PubMed:23420830, ECO:0000269|PubMed:24167619, ECO:0000269|PubMed:25370050, ECO:0000269|PubMed:26279430, ECO:0000269|PubMed:26392562, ECO:0000269|PubMed:26776555}. |
Q14680 | MELK | S253 | psp | Maternal embryonic leucine zipper kinase (hMELK) (EC 2.7.11.1) (Protein kinase Eg3) (pEg3 kinase) (Protein kinase PK38) (hPK38) (Tyrosine-protein kinase MELK) (EC 2.7.10.2) | Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis. {ECO:0000269|PubMed:11802789, ECO:0000269|PubMed:12400006, ECO:0000269|PubMed:14699119, ECO:0000269|PubMed:15908796, ECO:0000269|PubMed:16216881, ECO:0000269|PubMed:17280616}. |
Q147X3 | NAA30 | S199 | ochoa | N-alpha-acetyltransferase 30 (EC 2.3.1.256) (N-acetyltransferase 12) (N-acetyltransferase MAK3 homolog) (NatC catalytic subunit) | Catalytic subunit of the N-terminal acetyltransferase C (NatC) complex (PubMed:19398576, PubMed:37891180). Catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Leu-Ala and Met-Leu-Gly (PubMed:19398576, PubMed:37891180). N-terminal acetylation protects proteins from ubiquitination and degradation by the N-end rule pathway (PubMed:37891180). Necessary for the lysosomal localization and function of ARL8B sugeesting that ARL8B is a NatC substrate (PubMed:19398576). {ECO:0000269|PubMed:19398576, ECO:0000269|PubMed:37891180}. |
Q15084 | PDIA6 | S230 | ochoa | Protein disulfide-isomerase A6 (EC 5.3.4.1) (Endoplasmic reticulum protein 5) (ER protein 5) (ERp5) (Protein disulfide isomerase P5) (Thioredoxin domain-containing protein 7) | May function as a chaperone that inhibits aggregation of misfolded proteins (PubMed:12204115). Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (PubMed:24508390). May also regulate the UPR via the EIF2AK3 UPR sensor (PubMed:24508390). Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (PubMed:15466936). {ECO:0000269|PubMed:12204115, ECO:0000269|PubMed:15466936, ECO:0000269|PubMed:24508390}. |
Q15303 | ERBB4 | S1124 | ochoa | Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)] | Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration. Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote nuclear import of STAT5A, activation of STAT5A, mammary epithelium differentiation, cell proliferation and activation of gene expression. The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactation. The ERBB4 soluble intracellular domains can also translocate to mitochondria and promote apoptosis. {ECO:0000269|PubMed:10348342, ECO:0000269|PubMed:10353604, ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:10722704, ECO:0000269|PubMed:10867024, ECO:0000269|PubMed:11178955, ECO:0000269|PubMed:11390655, ECO:0000269|PubMed:12807903, ECO:0000269|PubMed:15534001, ECO:0000269|PubMed:15746097, ECO:0000269|PubMed:16251361, ECO:0000269|PubMed:16778220, ECO:0000269|PubMed:16837552, ECO:0000269|PubMed:17486069, ECO:0000269|PubMed:17638867, ECO:0000269|PubMed:19098003, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:8383326, ECO:0000269|PubMed:8617750, ECO:0000269|PubMed:9135143, ECO:0000269|PubMed:9168115, ECO:0000269|PubMed:9334263}. |
Q15468 | STIL | S475 | ochoa | SCL-interrupting locus protein (TAL-1-interrupting locus protein) | Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1 (PubMed:16024801, PubMed:9372240). Plays an important role in the regulation of centriole duplication. Required for the onset of procentriole formation and proper mitotic progression. During procentriole formation, is essential for the correct loading of SASS6 and CPAP to the base of the procentriole to initiate procentriole assembly (PubMed:22020124). In complex with STIL acts as a modulator of PLK4-driven cytoskeletal rearrangements and directional cell motility (PubMed:29712910, PubMed:32107292). {ECO:0000269|PubMed:16024801, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:29712910, ECO:0000269|PubMed:32107292, ECO:0000269|PubMed:9372240}. |
Q15477 | SKIC2 | S270 | ochoa | Superkiller complex protein 2 (Ski2) (EC 3.6.4.13) (Helicase-like protein) (HLP) | Helicase component of the SKI complex, a multiprotein complex that assists the RNA-degrading exosome during the mRNA decay and quality-control pathways (PubMed:16024656, PubMed:32006463, PubMed:35120588). The SKI complex catalyzes mRNA extraction from 80S ribosomal complexes in the 3'-5' direction and channels mRNA to the cytosolic exosome for degradation (PubMed:32006463, PubMed:35120588). SKI-mediated extraction of mRNA from stalled ribosomes allow binding of the Pelota-HBS1L complex and subsequent ribosome disassembly by ABCE1 for ribosome recycling (PubMed:32006463). In the nucleus, the SKI complex associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C) (PubMed:16024656). {ECO:0000269|PubMed:16024656, ECO:0000269|PubMed:32006463, ECO:0000269|PubMed:35120588}. |
Q15633 | TARBP2 | S152 | ochoa|psp | RISC-loading complex subunit TARBP2 (TAR RNA-binding protein 2) (Trans-activation-responsive RNA-binding protein) | Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1 (By similarity) (PubMed:15973356, PubMed:16142218, PubMed:16271387, PubMed:16357216, PubMed:16424907, PubMed:17452327, PubMed:18178619). Binds in vitro to the PRM1 3'-UTR (By similarity). Seems to act as a repressor of translation (By similarity). For some pre-miRNA substrates, may also alter the choice of cleavage site by DICER1 (PubMed:23063653). Negatively regulates IRF7-mediated IFN-beta signaling triggered by viral infection by inhibiting the phosphorylation of IRF7 and promoting its 'Lys'-48-linked ubiquitination and degradation (PubMed:30927622). {ECO:0000250|UniProtKB:P97473, ECO:0000255|HAMAP-Rule:MF_03034, ECO:0000269|PubMed:15973356, ECO:0000269|PubMed:16142218, ECO:0000269|PubMed:16271387, ECO:0000269|PubMed:16357216, ECO:0000269|PubMed:16424907, ECO:0000269|PubMed:17452327, ECO:0000269|PubMed:18178619, ECO:0000269|PubMed:23063653, ECO:0000269|PubMed:30927622}.; FUNCTION: (Microbial infection) Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs (PubMed:11438532, PubMed:12475984, PubMed:2011739). This is achieved in part at least by binding to and inhibiting EIF2AK2/PKR, thereby reducing phosphorylation and inhibition of EIF2S1/eIF-2-alpha (PubMed:11438532). May also promote translation of TAR-containing RNAs independently of EIF2AK2/PKR (PubMed:12475984). Mediates recruitment of FTSJ3 methyltransferase to HIV-1 RNA, leading to 2'-O-methylation of the viral genome, allowing HIV-1 to escape the innate immune system (PubMed:30626973). {ECO:0000269|PubMed:11438532, ECO:0000269|PubMed:12475984, ECO:0000269|PubMed:2011739, ECO:0000269|PubMed:30626973}. |
Q15648 | MED1 | S621 | ochoa | Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}. |
Q16512 | PKN1 | S301 | ochoa | Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protease-activated kinase 1) (PAK-1) (Protein kinase C-like 1) (Protein kinase C-like PKN) (Protein kinase PKN-alpha) (Protein-kinase C-related kinase 1) (Serine-threonine protein kinase N) | PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro. {ECO:0000269|PubMed:11104762, ECO:0000269|PubMed:12514133, ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:18066052, ECO:0000269|PubMed:20188095, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:21754995, ECO:0000269|PubMed:24248594, ECO:0000269|PubMed:8557118, ECO:0000269|PubMed:8621664, ECO:0000269|PubMed:9175763}. |
Q16563 | SYPL1 | S20 | ochoa | Synaptophysin-like protein 1 (Pantophysin) | None |
Q16625 | OCLN | S369 | ochoa | Occludin | May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions. {ECO:0000269|PubMed:19114660}.; FUNCTION: (Microbial infection) Acts as a coreceptor for hepatitis C virus (HCV) in hepatocytes. {ECO:0000269|PubMed:19182773, ECO:0000269|PubMed:20375010}. |
Q52LW3 | ARHGAP29 | S519 | ochoa | Rho GTPase-activating protein 29 (PTPL1-associated RhoGAP protein 1) (Rho-type GTPase-activating protein 29) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis. {ECO:0000269|PubMed:15752761, ECO:0000269|PubMed:9305890}. |
Q56NI9 | ESCO2 | S505 | ochoa | N-acetyltransferase ESCO2 (EC 2.3.1.-) (Establishment factor-like protein 2) (EFO2) (EFO2p) (hEFO2) (Establishment of cohesion 1 homolog 2) (ECO1 homolog 2) | Acetyltransferase required for the establishment of sister chromatid cohesion (PubMed:15821733, PubMed:15958495). Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during the S phase. Acetylates the cohesin component SMC3 (PubMed:21111234). {ECO:0000269|PubMed:15821733, ECO:0000269|PubMed:15958495, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:21111234}. |
Q5BKX6 | SLC45A4 | S333 | ochoa | Solute carrier family 45 member 4 | Proton-associated sucrose transporter. May be able to transport also glucose and fructose. {ECO:0000250|UniProtKB:Q0P5V9}. |
Q5SRH9 | TTC39A | S104 | ochoa | Tetratricopeptide repeat protein 39A (TPR repeat protein 39A) (Differentially expressed in MCF-7 with estradiol protein 6) (DEME-6) | None |
Q5T1R4 | HIVEP3 | S720 | ochoa | Transcription factor HIVEP3 (Human immunodeficiency virus type I enhancer-binding protein 3) (Kappa-B and V(D)J recombination signal sequences-binding protein) (Kappa-binding protein 1) (KBP-1) (Zinc finger protein ZAS3) | Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Also binds to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and pro-inflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation. {ECO:0000269|PubMed:11161801}. |
Q5T5P2 | KIAA1217 | S531 | ochoa | Sickle tail protein homolog | Required for normal development of intervertebral disks. {ECO:0000250|UniProtKB:A2AQ25}. |
Q5T7B8 | KIF24 | S990 | ochoa | Kinesin-like protein KIF24 | Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation (PubMed:21620453). Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle (PubMed:26290419). Plays an important role in recruiting MPHOSPH9, a negative regulator of cilia formation to the distal end of mother centriole (PubMed:30375385). {ECO:0000269|PubMed:21620453, ECO:0000269|PubMed:26290419, ECO:0000269|PubMed:30375385}. |
Q5TCZ1 | SH3PXD2A | S795 | ochoa | SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains) | Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells (PubMed:27789576). Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. {ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:15710328, ECO:0000269|PubMed:15710903, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497, ECO:0000269|PubMed:27789576}. |
Q5UIP0 | RIF1 | S1046 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
Q5VWG9 | TAF3 | S667 | ochoa | Transcription initiation factor TFIID subunit 3 (140 kDa TATA box-binding protein-associated factor) (TBP-associated factor 3) (Transcription initiation factor TFIID 140 kDa subunit) (TAF(II)140) (TAF140) (TAFII-140) (TAFII140) | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (PubMed:33795473). TAF3 forms the TFIID-A module together with TAF5 and TBP (PubMed:33795473). Required in complex with TBPL2 for the differentiation of myoblasts into myocytes (PubMed:11438666). The TAF3-TBPL2 complex replaces TFIID at specific promoters at an early stage in the differentiation process (PubMed:11438666). {ECO:0000269|PubMed:11438666, ECO:0000269|PubMed:33795473}. |
Q5VWQ8 | DAB2IP | S895 | ochoa | Disabled homolog 2-interacting protein (DAB2 interaction protein) (DAB2-interacting protein) (ASK-interacting protein 1) (AIP-1) (DOC-2/DAB-2 interactive protein) | Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Involved in several processes such as innate immune response, inflammation and cell growth inhibition, apoptosis, cell survival, angiogenesis, cell migration and maturation. Also plays a role in cell cycle checkpoint control; reduces G1 phase cyclin levels resulting in G0/G1 cell cycle arrest. Mediates signal transduction by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF), interferon (IFN) or lipopolysaccharide (LPS). Modulates the balance between phosphatidylinositol 3-kinase (PI3K)-AKT-mediated cell survival and apoptosis stimulated kinase (MAP3K5)-JNK signaling pathways; sequesters both AKT1 and MAP3K5 and counterbalances the activity of each kinase by modulating their phosphorylation status in response to pro-inflammatory stimuli. Acts as a regulator of the endoplasmic reticulum (ER) unfolded protein response (UPR) pathway; specifically involved in transduction of the ER stress-response to the JNK cascade through ERN1. Mediates TNF-alpha-induced apoptosis activation by facilitating dissociation of inhibitor 14-3-3 from MAP3K5; recruits the PP2A phosphatase complex which dephosphorylates MAP3K5 on 'Ser-966', leading to the dissociation of 13-3-3 proteins and activation of the MAP3K5-JNK signaling pathway in endothelial cells. Also mediates TNF/TRAF2-induced MAP3K5-JNK activation, while it inhibits CHUK-NF-kappa-B signaling. Acts a negative regulator in the IFN-gamma-mediated JAK-STAT signaling cascade by inhibiting smooth muscle cell (VSMCs) proliferation and intimal expansion, and thus, prevents graft arteriosclerosis (GA). Acts as a GTPase-activating protein (GAP) for the ADP ribosylation factor 6 (ARF6), Ras and RAB40C (PubMed:29156729). Promotes hydrolysis of the ARF6-bound GTP and thus, negatively regulates phosphatidylinositol 4,5-bisphosphate (PIP2)-dependent TLR4-TIRAP-MyD88 and NF-kappa-B signaling pathways in endothelial cells in response to lipopolysaccharides (LPS). Binds specifically to phosphatidylinositol 4-phosphate (PtdIns4P) and phosphatidylinositol 3-phosphate (PtdIns3P). In response to vascular endothelial growth factor (VEGFA), acts as a negative regulator of the VEGFR2-PI3K-mediated angiogenic signaling pathway by inhibiting endothelial cell migration and tube formation. In the developing brain, promotes both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex in a glial-dependent locomotion process. Probable downstream effector of the Reelin signaling pathway; promotes Purkinje cell (PC) dendrites development and formation of cerebellar synapses. Also functions as a tumor suppressor protein in prostate cancer progression; prevents cell proliferation and epithelial-to-mesenchymal transition (EMT) through activation of the glycogen synthase kinase-3 beta (GSK3B)-induced beta-catenin and inhibition of PI3K-AKT and Ras-MAPK survival downstream signaling cascades, respectively. {ECO:0000269|PubMed:12813029, ECO:0000269|PubMed:17389591, ECO:0000269|PubMed:18292600, ECO:0000269|PubMed:19033661, ECO:0000269|PubMed:19903888, ECO:0000269|PubMed:19948740, ECO:0000269|PubMed:20080667, ECO:0000269|PubMed:20154697, ECO:0000269|PubMed:21700930, ECO:0000269|PubMed:22696229, ECO:0000269|PubMed:29156729}. |
Q63HR2 | TNS2 | S903 | ochoa | Tensin-2 (EC 3.1.3.48) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase) | Tyrosine-protein phosphatase which regulates cell motility, proliferation and muscle-response to insulin (PubMed:15817639, PubMed:23401856). Phosphatase activity is mediated by binding to phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3) via the SH2 domain (PubMed:30092354). In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy (PubMed:23401856, PubMed:30092354). Negatively regulates PI3K-AKT pathway activation (PubMed:15817639, PubMed:23401856, PubMed:30092354). Dephosphorylates nephrin NPHS1 in podocytes which regulates activity of the mTORC1 complex (PubMed:28955049). Under normal glucose conditions, NPHS1 outcompetes IRS1 for binding to phosphatidylinositol 3-kinase (PI3K) which balances mTORC1 activity but high glucose conditions lead to up-regulation of TNS2, increased NPHS1 dephosphorylation and activation of mTORC1, contributing to podocyte hypertrophy and proteinuria (PubMed:28955049). Required for correct podocyte morphology, podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in promoting DLC1-dependent remodeling of the extracellular matrix (PubMed:20069572). {ECO:0000250|UniProtKB:Q8CGB6, ECO:0000269|PubMed:15817639, ECO:0000269|PubMed:20069572, ECO:0000269|PubMed:23401856, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:28955049, ECO:0000269|PubMed:30092354}. |
Q63ZY3 | KANK2 | S172 | ochoa | KN motif and ankyrin repeat domain-containing protein 2 (Ankyrin repeat domain-containing protein 25) (Matrix-remodeling-associated protein 3) (SRC-1-interacting protein) (SIP) (SRC-interacting protein) (SRC1-interacting protein) | Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (PubMed:17476305). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (PubMed:22371500). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (PubMed:22371500). Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (PubMed:17996375, PubMed:25961457). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457). Through the Rho signaling pathway may also regulate cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q8BX02, ECO:0000269|PubMed:17476305, ECO:0000269|PubMed:17996375, ECO:0000269|PubMed:22371500, ECO:0000269|PubMed:24671081, ECO:0000269|PubMed:25961457}. |
Q641Q2 | WASHC2A | S1142 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
Q66K14 | TBC1D9B | S407 | ochoa | TBC1 domain family member 9B | May act as a GTPase-activating protein for Rab family protein(s). |
Q68CZ2 | TNS3 | S840 | ochoa | Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6) | May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex (PubMed:17643115). EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1 (PubMed:17643115). Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA (PubMed:26166433). Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration (PubMed:35687021). Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1 (PubMed:31905841). {ECO:0000250|UniProtKB:Q5SSZ5, ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:31905841, ECO:0000269|PubMed:35687021, ECO:0000305}. |
Q6BDS2 | BLTP3A | S921 | ochoa | Bridge-like lipid transfer protein family member 3A (ICBP90-binding protein 1) (UHRF1-binding protein 1) (Ubiquitin-like containing PHD and RING finger domains 1-binding protein 1) | Tube-forming lipid transport protein which probably mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567). May be involved in the retrograde traffic of vesicle clusters in the endocytic pathway to the Golgi complex (PubMed:35499567). {ECO:0000269|PubMed:35499567}. |
Q6IQ22 | RAB12 | S223 | ochoa | Ras-related protein Rab-12 (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB12 may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor. Involved in autophagy (By similarity). {ECO:0000250|UniProtKB:P35283, ECO:0000250|UniProtKB:P61026}. |
Q6NSJ2 | PHLDB3 | S254 | ochoa | Pleckstrin homology-like domain family B member 3 | None |
Q6NTF9 | RHBDD2 | S276 | ochoa | Rhomboid domain-containing protein 2 | None |
Q6NZY4 | ZCCHC8 | S591 | ochoa | Zinc finger CCHC domain-containing protein 8 (TRAMP-like complex RNA-binding factor ZCCHC8) | Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex that is involved in the surveillance and turnover of aberrant transcripts and non-coding RNAs (PubMed:27871484). NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. May be involved in pre-mRNA splicing (Probable). It is required for 3'-end maturation of telomerase RNA component (TERC), TERC 3'-end targeting to the nuclear RNA exosome, and for telomerase function (PubMed:31488579). {ECO:0000269|PubMed:27871484, ECO:0000269|PubMed:31488579, ECO:0000305|PubMed:16263084}. |
Q6P0N0 | MIS18BP1 | S761 | ochoa | Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243) | Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038, ECO:0000269|PubMed:17339379}. |
Q6P996 | PDXDC1 | S748 | ochoa | Pyridoxal-dependent decarboxylase domain-containing protein 1 (EC 4.1.1.-) | None |
Q6R327 | RICTOR | S1346 | ochoa | Rapamycin-insensitive companion of mTOR (AVO3 homolog) (hAVO3) | Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15268862, PubMed:15718470, PubMed:19720745, PubMed:19995915, PubMed:21343617, PubMed:33158864, PubMed:35904232, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:19720745, PubMed:19935711, PubMed:19995915). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:15467718, PubMed:21343617). Within the mTORC2 complex, RICTOR probably acts as a molecular adapter (PubMed:21343617, PubMed:33158864, PubMed:35926713). RICTOR is responsible for the FKBP12-rapamycin-insensitivity of mTORC2 (PubMed:33158864). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:15718470, PubMed:19720745, PubMed:19935711, PubMed:35926713). mTORC2 catalyzes the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657' (By similarity). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:15467718). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (PubMed:15467718). {ECO:0000250|UniProtKB:Q6QI06, ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15718470, ECO:0000269|PubMed:19720745, ECO:0000269|PubMed:19935711, ECO:0000269|PubMed:19995915, ECO:0000269|PubMed:21343617, ECO:0000269|PubMed:33158864, ECO:0000269|PubMed:35904232, ECO:0000269|PubMed:35926713}. |
Q71U36 | TUBA1A | S165 | psp | Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
Q7Z2K8 | GPRIN1 | S608 | ochoa | G protein-regulated inducer of neurite outgrowth 1 (GRIN1) | May be involved in neurite outgrowth. {ECO:0000250}. |
Q7Z2K8 | GPRIN1 | S776 | ochoa | G protein-regulated inducer of neurite outgrowth 1 (GRIN1) | May be involved in neurite outgrowth. {ECO:0000250}. |
Q7Z2Z1 | TICRR | S292 | ochoa | Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) | Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}. |
Q7Z309 | PABIR2 | S33 | ochoa | PABIR family member 2 | None |
Q7Z3B3 | KANSL1 | S1015 | ochoa | KAT8 regulatory NSL complex subunit 1 (MLL1/MLL complex subunit KANSL1) (MSL1 homolog 1) (hMSL1v1) (NSL complex protein NSL1) (Non-specific lethal 1 homolog) | Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (PubMed:20018852, PubMed:22547026, PubMed:33657400). The NSL complex also acts as a regulator of gene expression in mitochondria (PubMed:27768893). In addition to its role in transcription, KANSL1 also plays an essential role in spindle assembly during mitosis (PubMed:26243146). Associates with microtubule ends and contributes to microtubule stability (PubMed:26243146). {ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:26243146, ECO:0000269|PubMed:27768893, ECO:0000269|PubMed:33657400}. |
Q7Z3T8 | ZFYVE16 | S319 | ochoa | Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome-associated FYVE domain protein) | May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes. {ECO:0000269|PubMed:11546807, ECO:0000269|PubMed:14613930}. |
Q7Z5H3 | ARHGAP22 | S346 | ochoa | Rho GTPase-activating protein 22 (Rho-type GTPase-activating protein 22) | Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter (By similarity). {ECO:0000250}. |
Q86TC9 | MYPN | S101 | ochoa | Myopalladin (145 kDa sarcomeric protein) | Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines. {ECO:0000269|PubMed:11309420}. |
Q86TI0 | TBC1D1 | S575 | ochoa | TBC1 domain family member 1 | May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity). {ECO:0000250}. |
Q86TU7 | SETD3 | S512 | ochoa | Actin-histidine N-methyltransferase (EC 2.1.1.85) (Protein-L-histidine N-tele-methyltransferase) (SET domain-containing protein 3) (hSETD3) | Protein-histidine N-methyltransferase that specifically mediates 3-methylhistidine (tele-methylhistidine) methylation of actin at 'His-73' (PubMed:30526847, PubMed:30626964, PubMed:30785395, PubMed:31388018, PubMed:31993215). Histidine methylation of actin is required for smooth muscle contraction of the laboring uterus during delivery (PubMed:30626964). Does not have protein-lysine N-methyltransferase activity and probably only catalyzes histidine methylation of actin (PubMed:30626964, PubMed:30785395, PubMed:31388018). {ECO:0000269|PubMed:30526847, ECO:0000269|PubMed:30626964, ECO:0000269|PubMed:30785395, ECO:0000269|PubMed:31388018, ECO:0000269|PubMed:31993215}. |
Q86W92 | PPFIBP1 | S379 | ochoa | Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1) (hSGT2) | May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A. {ECO:0000269|PubMed:9624153}. |
Q8IVJ1 | SLC41A1 | S80 | ochoa | Solute carrier family 41 member 1 | Na(+)/Mg(2+) ion exchanger that acts as a predominant Mg(2+) efflux system at the plasma membrane (PubMed:18367447, PubMed:22031603, PubMed:23661805, PubMed:23976986). Transporter activity is driven by the inwardly directed electrochemical gradient for Na(+) ions, thus directly depends on the extracellular Na(+) ion concentration set by Na(+)/K(+) pump (PubMed:22031603, PubMed:23661805). Generates circadian cellular Mg(2+) fluxes that feed back to regulate clock-controlled gene expression and metabolism and facilitate higher energetic demands during the day (PubMed:27074515). Has a role in regulating the activity of ATP-dependent enzymes, including those operating in Krebs cycle and the electron transport chain (By similarity). {ECO:0000250|UniProtKB:Q8BJA2, ECO:0000269|PubMed:18367447, ECO:0000269|PubMed:22031603, ECO:0000269|PubMed:23661805, ECO:0000269|PubMed:23976986, ECO:0000269|PubMed:27074515}. |
Q8IVT5 | KSR1 | S267 | ochoa | Kinase suppressor of Ras 1 (EC 2.7.11.1) | Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases (By similarity). Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 (PubMed:29433126). Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP (By similarity). Its kinase activity is unsure (By similarity). Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown (By similarity). {ECO:0000250|UniProtKB:Q61097, ECO:0000269|PubMed:29433126}. |
Q8IWB9 | TEX2 | S230 | ochoa | Testis-expressed protein 2 (Transmembrane protein 96) | During endoplasmic reticulum (ER) stress or when cellular ceramide levels increase, may induce contacts between the ER and medial-Golgi complex to facilitate non-vesicular transport of ceramides from the ER to the Golgi complex where they are converted to complex sphingolipids, preventing toxic ceramide accumulation. {ECO:0000269|PubMed:28011845}. |
Q8IX01 | SUGP2 | S1032 | ochoa | SURP and G-patch domain-containing protein 2 (Arginine/serine-rich-splicing factor 14) (Splicing factor, arginine/serine-rich 14) | May play a role in mRNA splicing. {ECO:0000305}. |
Q8IYW5 | RNF168 | S393 | ochoa | E3 ubiquitin-protein ligase RNF168 (hRNF168) (EC 2.3.2.27) (RING finger protein 168) (RING-type E3 ubiquitin transferase RNF168) | E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20/C1orf86 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. Following DNA damage, promotes the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF8, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Not able to initiate 'Lys-63'-linked ubiquitination in vitro; possibly due to partial occlusion of the UBE2N/UBC13-binding region. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively). {ECO:0000255|HAMAP-Rule:MF_03066, ECO:0000269|PubMed:19203578, ECO:0000269|PubMed:19203579, ECO:0000269|PubMed:20550933, ECO:0000269|PubMed:22373579, ECO:0000269|PubMed:22705371, ECO:0000269|PubMed:22713238, ECO:0000269|PubMed:22742833, ECO:0000269|PubMed:22980979, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538}. |
Q8IZD4 | DCP1B | S559 | ochoa | mRNA-decapping enzyme 1B (EC 3.6.1.62) | May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (By similarity). {ECO:0000250|UniProtKB:Q9NPI6}. |
Q8N4X5 | AFAP1L2 | S767 | ochoa | Actin filament-associated protein 1-like 2 (AFAP1-like protein 2) | May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation. {ECO:0000269|PubMed:17412687}. |
Q8N680 | ZBTB2 | S491 | ochoa | Zinc finger and BTB domain-containing protein 2 | May be involved in transcriptional regulation. |
Q8N7R7 | CCNYL1 | S105 | ochoa | Cyclin-Y-like protein 1 | Key regulator of Wnt signaling implicated in various biological processes including male fertility, embryonic neurogenesis and cortex development. Activates the cyclin-dependent kinase CDK16, and promotes sperm maturation. {ECO:0000250|UniProtKB:D3YUJ3}. |
Q8ND76 | CCNY | S83 | ochoa|psp | Cyclin-Y (Cyc-Y) (Cyclin box protein 1) (Cyclin fold protein 1) (cyclin-X) | Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription. {ECO:0000269|PubMed:18060517, ECO:0000269|PubMed:19524571, ECO:0000269|PubMed:20059949, ECO:0000269|PubMed:22184064}. |
Q8NEY1 | NAV1 | S152 | ochoa | Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) | May be involved in neuronal migration. {ECO:0000250}. |
Q8TB61 | SLC35B2 | S137 | ochoa | Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (PAPS transporter 1) (Putative MAPK-activating protein PM15) (Putative NF-kappa-B-activating protein 48) (Solute carrier family 35 member B2) | Probably functions as a 3'-phosphoadenylyl sulfate:adenosine 3',5'-bisphosphate antiporter at the Golgi membranes. Mediates the transport from the cytosol into the lumen of the Golgi of 3'-phosphoadenylyl sulfate/adenosine 3'-phospho 5'-phosphosulfate (PAPS), a universal sulfuryl donor for sulfation events that take place in that compartment. {ECO:0000269|PubMed:12716889}. |
Q8TDM6 | DLG5 | S1146 | ochoa | Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG) | Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). {ECO:0000250|UniProtKB:E9Q9R9, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:28169360}. |
Q8TER5 | ARHGEF40 | S1480 | ochoa | Rho guanine nucleotide exchange factor 40 (Protein SOLO) | May act as a guanine nucleotide exchange factor (GEF). {ECO:0000250}. |
Q8WUB8 | PHF10 | S270 | ochoa | PHD finger protein 10 (BRG1-associated factor 45a) (BAF45a) (XAP135) | Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250}. |
Q8WUM0 | NUP133 | S1021 | ochoa | Nuclear pore complex protein Nup133 (133 kDa nucleoporin) (Nucleoporin Nup133) | Involved in poly(A)+ RNA transport. Involved in nephrogenesis (PubMed:30179222). {ECO:0000269|PubMed:11684705, ECO:0000269|PubMed:30179222}. |
Q8WWI1 | LMO7 | S221 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
Q8WX92 | NELFB | S557 | ochoa | Negative elongation factor B (NELF-B) (Cofactor of BRCA1) | Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (PubMed:12612062). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (PubMed:10199401). May be able to induce chromatin unfolding (PubMed:11739404). Essential for early embryogenesis; plays an important role in maintaining the undifferentiated state of embryonic stem cells (ESCs) by preventing unscheduled expression of developmental genes (By similarity). Plays a key role in establishing the responsiveness of stem cells to developmental cues; facilitates plasticity and cell fate commitment in ESCs by establishing the appropriate expression level of signaling molecules (By similarity). Supports the transcription of genes involved in energy metabolism in cardiomyocytes; facilitates the association of transcription initiation factors with the promoters of the metabolism-related genes (By similarity). {ECO:0000250|UniProtKB:Q8C4Y3, ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:11739404, ECO:0000269|PubMed:12612062}.; FUNCTION: (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II (PubMed:23884411). In vitro, binds weakly to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1 (PubMed:23884411). {ECO:0000269|PubMed:23884411}. |
Q8WYL5 | SSH1 | S834 | ochoa|psp | Protein phosphatase Slingshot homolog 1 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 1) (SSH-1L) (hSSH-1L) | Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. {ECO:0000269|PubMed:11832213, ECO:0000269|PubMed:12684437, ECO:0000269|PubMed:12807904, ECO:0000269|PubMed:14531860, ECO:0000269|PubMed:14645219, ECO:0000269|PubMed:15056216, ECO:0000269|PubMed:15159416, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:15671020, ECO:0000269|PubMed:16230460}. |
Q8WYQ5 | DGCR8 | S383 | ochoa | Microprocessor complex subunit DGCR8 (DiGeorge syndrome critical region 8) | Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs (PubMed:26027739, PubMed:26748718). The heme-bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer (of dimers) and is active in triggering pri-miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri-miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding (PubMed:15531877, PubMed:15574589, PubMed:15589161, PubMed:16751099, PubMed:16906129, PubMed:16963499, PubMed:17159994). Specifically recognizes and binds N6-methyladenosine (m6A)-containing pri-miRNAs, a modification required for pri-miRNAs processing (PubMed:25799998). Involved in the silencing of embryonic stem cell self-renewal (By similarity). Also plays a role in DNA repair by promoting the recruitment of RNF168 to RNF8 and MDC1 at DNA double-strand breaks and subsequently the clearance of DNA breaks (PubMed:34188037). {ECO:0000250|UniProtKB:Q9EQM6, ECO:0000269|PubMed:15531877, ECO:0000269|PubMed:15574589, ECO:0000269|PubMed:15589161, ECO:0000269|PubMed:16751099, ECO:0000269|PubMed:16906129, ECO:0000269|PubMed:16963499, ECO:0000269|PubMed:17159994, ECO:0000269|PubMed:25799998, ECO:0000269|PubMed:26027739, ECO:0000269|PubMed:26748718}. |
Q92585 | MAML1 | S159 | ochoa | Mastermind-like protein 1 (Mam-1) | Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. {ECO:0000269|PubMed:11101851, ECO:0000269|PubMed:11390662, ECO:0000269|PubMed:12050117, ECO:0000269|PubMed:15546612, ECO:0000269|PubMed:17317671}. |
Q92585 | MAML1 | S283 | ochoa | Mastermind-like protein 1 (Mam-1) | Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. {ECO:0000269|PubMed:11101851, ECO:0000269|PubMed:11390662, ECO:0000269|PubMed:12050117, ECO:0000269|PubMed:15546612, ECO:0000269|PubMed:17317671}. |
Q92614 | MYO18A | S736 | ochoa | Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210) | May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939). {ECO:0000250|UniProtKB:Q9JMH9, ECO:0000269|PubMed:16087679, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:21123169, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:25965346, ECO:0000269|PubMed:27467939}. |
Q92844 | TANK | S230 | ochoa | TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF) | Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989). Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989). May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. {ECO:0000269|PubMed:12133833, ECO:0000269|PubMed:21931631, ECO:0000269|PubMed:25861989}. |
Q92844 | TANK | S357 | ochoa | TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF) | Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989). Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989). May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. {ECO:0000269|PubMed:12133833, ECO:0000269|PubMed:21931631, ECO:0000269|PubMed:25861989}. |
Q92918 | MAP4K1 | S737 | ochoa | Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (Hematopoietic progenitor kinase) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) | Serine/threonine-protein kinase, which plays a role in the response to environmental stress (PubMed:24362026). Appears to act upstream of the JUN N-terminal pathway (PubMed:8824585). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). May play a role in hematopoietic lineage decisions and growth regulation (PubMed:24362026, PubMed:8824585). Together with CLNK, it enhances CD3-triggered activation of T-cells and subsequent IL2 production (By similarity). {ECO:0000250|UniProtKB:P70218, ECO:0000269|PubMed:24362026, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:8824585}. |
Q92994 | BRF1 | S398 | ochoa | Transcription factor IIIB 90 kDa subunit (TFIIIB90) (hTFIIIB90) (B-related factor 1) (BRF-1) (hBRF) (TAF3B2) (TATA box-binding protein-associated factor, RNA polymerase III, subunit 2) | General activator of RNA polymerase which utilizes different TFIIIB complexes at structurally distinct promoters. The isoform 1 is involved in the transcription of tRNA, adenovirus VA1, 7SL and 5S RNA. Isoform 2 is required for transcription of the U6 promoter. |
Q93015 | NAA80 | S217 | ochoa | N-alpha-acetyltransferase 80 (HsNAAA80) (EC 2.3.1.-) (N-acetyltransferase 6) (Protein fusion-2) (Protein fus-2) | N-alpha-acetyltransferase that specifically mediates the acetylation of the acidic amino terminus of processed forms of beta- and gamma-actin (ACTB and ACTG, respectively) (PubMed:29581253, PubMed:30028079). N-terminal acetylation of processed beta- and gamma-actin regulates actin filament depolymerization and elongation (PubMed:29581253). In vivo, preferentially displays N-terminal acetyltransferase activity towards acid N-terminal sequences starting with Asp-Asp-Asp and Glu-Glu-Glu (PubMed:29581253, PubMed:30028079). In vitro, shows high activity towards Met-Asp-Glu-Leu and Met-Asp-Asp-Asp (PubMed:10644992, PubMed:29581307). May act as a tumor suppressor (PubMed:10644992). {ECO:0000269|PubMed:10644992, ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29581307, ECO:0000269|PubMed:30028079}. |
Q96A49 | SYAP1 | S231 | ochoa | Synapse-associated protein 1 (BSD domain-containing signal transducer and Akt interactor protein) (BSTA) | Plays a role in adipocyte differentiation by promoting mTORC2-mediated phosphorylation of AKT1 at 'Ser-473' after growth factor stimulation (PubMed:23300339). {ECO:0000269|PubMed:23300339}. |
Q96EK6 | GNPNAT1 | S27 | ochoa | Glucosamine 6-phosphate N-acetyltransferase (EC 2.3.1.4) (Phosphoglucosamine acetylase) (Phosphoglucosamine transacetylase) | None |
Q96H55 | MYO19 | S685 | ochoa | Unconventional myosin-XIX (Myosin head domain-containing protein 1) | Actin-based motor molecule with ATPase activity that localizes to the mitochondrion outer membrane (PubMed:19932026, PubMed:23568824, PubMed:25447992). Motor protein that moves towards the plus-end of actin filaments (By similarity). Required for mitochondrial inheritance during mitosis (PubMed:25447992). May be involved in mitochondrial transport or positioning (PubMed:23568824). {ECO:0000250|UniProtKB:Q5SV80, ECO:0000269|PubMed:19932026, ECO:0000269|PubMed:25447992, ECO:0000305|PubMed:23568824}. |
Q96HB5 | CCDC120 | S498 | ochoa | Coiled-coil domain-containing protein 120 | Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells (PubMed:28422092). Together with CCDC68, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly (PubMed:28422092). Recruits NIN and CEP170 to centrosomes (PubMed:28422092). Also required for neurite growth. Localizes CYTH2 to vesicles to allow its transport along neurites, and subsequent ARF6 activation and neurite growth. {ECO:0000269|PubMed:25326380}. |
Q96JB2 | COG3 | S533 | ochoa | Conserved oligomeric Golgi complex subunit 3 (COG complex subunit 3) (Component of oligomeric Golgi complex 3) (Vesicle-docking protein SEC34 homolog) (p94) | Involved in ER-Golgi transport (PubMed:11929878). Also involved in retrograde (Golgi to ER) transport (PubMed:37711075). {ECO:0000269|PubMed:11929878, ECO:0000269|PubMed:37711075}. |
Q96L73 | NSD1 | S1077 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) | Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context. {ECO:0000269|PubMed:21196496}. |
Q96MU7 | YTHDC1 | S122 | ochoa | YTH domain-containing protein 1 (Splicing factor YT521) (YT521-B) | Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:25242552, PubMed:26318451, PubMed:26876937, PubMed:28984244). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:25242552, PubMed:26318451). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May also regulate alternative splice site selection (PubMed:20167602). Also involved in nuclear export of m6A-containing mRNAs via interaction with SRSF3: interaction with SRSF3 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). Involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts, probably by binding m6A-containing MAT2A mRNAs (By similarity). Also recognizes and binds m6A on other RNA molecules (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: recognizes and binds m6A-containing Xist and promotes transcription repression activity of Xist (PubMed:27602518). Also recognizes and binds m6A-containing single-stranded DNA (PubMed:32663306). Involved in germline development: required for spermatogonial development in males and oocyte growth and maturation in females, probably via its role in alternative splicing (By similarity). {ECO:0000250|UniProtKB:E9Q5K9, ECO:0000269|PubMed:20167602, ECO:0000269|PubMed:25242552, ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:26876937, ECO:0000269|PubMed:27602518, ECO:0000269|PubMed:28984244, ECO:0000269|PubMed:32663306}. |
Q96QU8 | XPO6 | S199 | ochoa | Exportin-6 (Exp6) (Ran-binding protein 20) | Mediates the nuclear export of actin and profilin-actin complexes in somatic cells. {ECO:0000269|PubMed:14592989}. |
Q99661 | KIF2C | S95 | ochoa|psp | Kinesin-like protein KIF2C (Kinesin-like protein 6) (Mitotic centromere-associated kinesin) (MCAK) | In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells (PubMed:21820309). Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis (PubMed:19060894). Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment (PubMed:23891108). {ECO:0000269|PubMed:19060894, ECO:0000269|PubMed:21820309, ECO:0000269|PubMed:23891108}. |
Q99747 | NAPG | S284 | ochoa | Gamma-soluble NSF attachment protein (SNAP-gamma) (N-ethylmaleimide-sensitive factor attachment protein gamma) | Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. |
Q99801 | NKX3-1 | S48 | psp | Homeobox protein Nkx-3.1 (Homeobox protein NK-3 homolog A) | Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. {ECO:0000269|PubMed:19462257}. |
Q99959 | PKP2 | S227 | ochoa | Plakophilin-2 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:25208567). Regulates focal adhesion turnover resulting in changes in focal adhesion size, cell adhesion and cell spreading, potentially via transcriptional modulation of beta-integrins (PubMed:23884246). Required to maintain gingival epithelial barrier function (PubMed:34368962). Important component of the desmosome that is also required for localization of desmosome component proteins such as DSC2, DSG2 and JUP to the desmosome cell-cell junction (PubMed:22781308, PubMed:25208567). Required for the formation of desmosome cell junctions in cardiomyocytes, thereby required for the correct formation of the heart, specifically trabeculation and formation of the atria walls (By similarity). Loss of desmosome cell junctions leads to mis-localization of DSP and DSG2 resulting in disruption of cell-cell adhesion and disordered intermediate filaments (By similarity). Modulates profibrotic gene expression in cardiomyocytes via regulation of DSP expression and subsequent activation of downstream TGFB1 and MAPK14/p38 MAPK signaling (By similarity). Required for cardiac sodium current propagation and electrical synchrony in cardiac myocytes, via ANK3 stabilization and modulation of SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). Required for mitochondrial function, nuclear envelope integrity and positive regulation of SIRT3 transcription via maintaining DES localization at its nuclear envelope and cell tip anchoring points, and thereby preserving regulation of the transcriptional program (PubMed:35959657). Maintenance of nuclear envelope integrity protects against DNA damage and transcriptional dysregulation of genes, especially those involved in the electron transport chain, thereby preserving mitochondrial function and protecting against superoxide radical anion generation (PubMed:35959657). Binds single-stranded DNA (ssDNA) (PubMed:20613778). May regulate the localization of GJA1 to gap junctions in intercalated disks of the heart (PubMed:18662195). Involved in the inhibition of viral infection by influenza A viruses (IAV) (PubMed:28169297). Acts as a host restriction factor for IAV viral propagation, potentially via disrupting the interaction of IAV polymerase complex proteins (PubMed:28169297). {ECO:0000250|UniProtKB:F1M7L9, ECO:0000250|UniProtKB:Q9CQ73, ECO:0000269|PubMed:18662195, ECO:0000269|PubMed:20613778, ECO:0000269|PubMed:22781308, ECO:0000269|PubMed:23884246, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:28169297, ECO:0000269|PubMed:34368962, ECO:0000269|PubMed:35959657}. |
Q9BQ52 | ELAC2 | S217 | ochoa | Zinc phosphodiesterase ELAC protein 2 (EC 3.1.26.11) (ElaC homolog protein 2) (Heredity prostate cancer protein 2) (Ribonuclease Z 2) (RNase Z 2) (tRNA 3 endonuclease 2) (tRNase Z 2) | Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (PubMed:21593607). Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly (PubMed:24703694). {ECO:0000269|PubMed:21593607, ECO:0000269|PubMed:24703694}. |
Q9BQE3 | TUBA1C | S165 | psp | Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
Q9BT22 | ALG1 | S242 | ochoa | Chitobiosyldiphosphodolichol beta-mannosyltransferase (EC 2.4.1.142) (Asparagine-linked glycosylation protein 1 homolog) (Beta-1,4-mannosyltransferase) (GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase) (GDP-mannose-dolichol diphosphochitobiose mannosyltransferase) (Mannosyltransferase-1) (MT-1) (hMat-1) | Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes, on the cytoplasmic face of the endoplasmic reticulum, the addition of the first mannose residues to the dolichol-linked oligosaccharide chain, to produce Man1GlcNAc(2)-PP-dolichol core oligosaccharide. Man1GlcNAc(2)-PP-dolichol is a substrate for ALG2, the following enzyme in the biosynthetic pathway. {ECO:0000269|PubMed:10704531, ECO:0000269|PubMed:14973778, ECO:0000269|PubMed:26931382}. |
Q9BTC0 | DIDO1 | S1327 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
Q9BVJ6 | UTP14A | S434 | ochoa | U3 small nucleolar RNA-associated protein 14 homolog A (Antigen NY-CO-16) (Serologically defined colon cancer antigen 16) | May be required for ribosome biogenesis. {ECO:0000250}. |
Q9BW85 | YJU2 | S211 | ochoa | Splicing factor YJU2 (Coiled-coil domain-containing protein 94) | Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA (PubMed:29301961). Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates (By similarity). May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex (PubMed:22952453). {ECO:0000255|HAMAP-Rule:MF_03226, ECO:0000269|PubMed:22952453, ECO:0000269|PubMed:29301961}. |
Q9BW85 | YJU2 | S220 | ochoa | Splicing factor YJU2 (Coiled-coil domain-containing protein 94) | Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA (PubMed:29301961). Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates (By similarity). May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex (PubMed:22952453). {ECO:0000255|HAMAP-Rule:MF_03226, ECO:0000269|PubMed:22952453, ECO:0000269|PubMed:29301961}. |
Q9BWT1 | CDCA7 | S142 | ochoa | Cell division cycle-associated protein 7 (Protein JPO1) | Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. May play a role as transcriptional regulator. {ECO:0000269|PubMed:11598121, ECO:0000269|PubMed:15994934, ECO:0000269|PubMed:16580749, ECO:0000269|PubMed:23166294}. |
Q9BXP5 | SRRT | S540 | ochoa | Serrate RNA effector molecule homolog (Arsenite-resistance protein 2) | Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity). {ECO:0000250, ECO:0000269|PubMed:19632182}. |
Q9BY89 | KIAA1671 | S1293 | ochoa | Uncharacterized protein KIAA1671 | None |
Q9BZQ8 | NIBAN1 | S581 | ochoa | Protein Niban 1 (Cell growth-inhibiting gene 39 protein) (Protein FAM129A) | Regulates phosphorylation of a number of proteins involved in translation regulation including EIF2A, EIF4EBP1 and RPS6KB1. May be involved in the endoplasmic reticulum stress response (By similarity). {ECO:0000250}. |
Q9C004 | SPRY4 | S125 | ochoa | Protein sprouty homolog 4 (Spry-4) | Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras (PubMed:12027893). Probably impairs the formation of GTP-Ras (PubMed:12027893). Inhibits Ras-independent, but not Ras-dependent, activation of RAF1 (PubMed:12717443). Represses integrin-mediated cell spreading via inhibition of TESK1-mediated phosphorylation of cofilin (PubMed:15584898). {ECO:0000269|PubMed:12027893, ECO:0000269|PubMed:12717443, ECO:0000269|PubMed:15584898}. |
Q9GZY6 | LAT2 | Y58 | psp | Linker for activation of T-cells family member 2 (Linker for activation of B-cells) (Membrane-associated adapter molecule) (Non-T-cell activation linker) (Williams-Beuren syndrome chromosomal region 15 protein) (Williams-Beuren syndrome chromosomal region 5 protein) | Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2. {ECO:0000269|PubMed:12486104, ECO:0000269|PubMed:12514734, ECO:0000269|PubMed:15010370}. |
Q9H2M9 | RAB3GAP2 | S915 | ochoa | Rab3 GTPase-activating protein non-catalytic subunit (RGAP-iso) (Rab3 GTPase-activating protein 150 kDa subunit) (Rab3-GAP p150) (Rab3-GAP150) (Rab3-GAP regulatory subunit) | Regulatory subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of RAB3GAP1 and RAB3GAP2, which has GTPase-activating protein (GAP) activity towards various Rab3 subfamily members (RAB3A, RAB3B, RAB3C and RAB3D), RAB5A and RAB43, and guanine nucleotide exchange factor (GEF) activity towards RAB18 (PubMed:24891604, PubMed:9733780). As part of the Rab3GAP complex, acts as a GAP for Rab3 proteins by converting active RAB3-GTP to the inactive form RAB3-GDP (By similarity). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones (By similarity). The Rab3GAP complex acts as a GEF for RAB18 by promoting the conversion of inactive RAB18-GDP to the active form RAB18-GTP (PubMed:24891604). Recruits and stabilizes RAB18 at the cis-Golgi membrane in human fibroblasts where RAB18 is most likely activated (PubMed:26063829). Also involved in RAB18 recruitment at the endoplasmic reticulum (ER) membrane where it maintains proper ER structure (PubMed:24891604). Required for normal eye and brain development (By similarity). May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters (By similarity). {ECO:0000250|UniProtKB:Q15042, ECO:0000269|PubMed:24891604, ECO:0000269|PubMed:26063829, ECO:0000269|PubMed:9733780}. |
Q9H334 | FOXP1 | S83 | ochoa | Forkhead box protein P1 (Mac-1-regulated forkhead) (MFH) | Transcriptional repressor (PubMed:18347093, PubMed:26647308). Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal cord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintenance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18 (By similarity). Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis (PubMed:25267198). Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor (PubMed:15286807, PubMed:18347093, PubMed:18799727). Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B (PubMed:24023716). Can negatively regulate androgen receptor signaling (PubMed:18640093). Acts as a transcriptional activator of the FBXL7 promoter; this activity is regulated by AURKA (PubMed:28218735). {ECO:0000250|UniProtKB:P58462, ECO:0000269|PubMed:15286807, ECO:0000269|PubMed:18640093, ECO:0000269|PubMed:18799727, ECO:0000269|PubMed:24023716, ECO:0000269|PubMed:25267198, ECO:0000269|PubMed:26647308, ECO:0000269|PubMed:28218735, ECO:0000305|PubMed:18347093, ECO:0000305|PubMed:24023716}.; FUNCTION: [Isoform 8]: Involved in transcriptional regulation in embryonic stem cells (ESCs). Stimulates expression of transcription factors that are required for pluripotency and decreases expression of differentiation-associated genes. Has distinct DNA-binding specifities as compared to the canonical form and preferentially binds DNA with the sequence 5'-CGATACAA-3' (or closely related sequences) (PubMed:21924763). Promotes ESC self-renewal and pluripotency (By similarity). {ECO:0000250|UniProtKB:P58462, ECO:0000269|PubMed:21924763}. |
Q9H444 | CHMP4B | S184 | ochoa | Charged multivesicular body protein 4b (Chromatin-modifying protein 4b) (CHMP4b) (SNF7 homolog associated with Alix 1) (SNF7-2) (hSnf7-2) (Vacuolar protein sorting-associated protein 32-2) (Vps32-2) (hVps32-2) | Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released (PubMed:12860994, PubMed:18209100). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:21310966). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Plays a role in the endosomal sorting pathway. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4B filaments can promote or stabilize negative curvature and outward budding. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). Majority of the protein exists in a folded closed conformation (PubMed:33349255). {ECO:0000269|PubMed:12860994, ECO:0000269|PubMed:18209100, ECO:0000269|PubMed:21310966, ECO:0000269|PubMed:22660413, ECO:0000269|PubMed:26040712, ECO:0000269|PubMed:33349255}.; FUNCTION: (Microbial infection) The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the budding of enveloped viruses (HIV-1 and other lentiviruses). Via its interaction with PDCD6IP involved in HIV-1 p6- and p9-dependent virus release. {ECO:0000269|PubMed:14505569, ECO:0000269|PubMed:14505570, ECO:0000269|PubMed:14519844, ECO:0000269|PubMed:22422861}. |
Q9H4A3 | WNK1 | S2002 | ochoa | Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1) | Serine/threonine-protein kinase component of the WNK1-SPAK/OSR1 kinase cascade, which acts as a key regulator of blood pressure and regulatory volume increase by promoting ion influx (PubMed:15883153, PubMed:17190791, PubMed:31656913, PubMed:34289367, PubMed:36318922). WNK1 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK1 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK1-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:15883153, PubMed:16263722, PubMed:17190791, PubMed:19739668, PubMed:21321328, PubMed:22989884, PubMed:25477473, PubMed:34289367, PubMed:36318922). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A5/KCC2 and SLC12A6/KCC3, regulating their activity (PubMed:16263722, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:19665974, PubMed:21321328). Also acts as a regulator of angiogenesis in endothelial cells via activation of OXSR1/OSR1 and STK39/SPAK: activation of OXSR1/OSR1 regulates chemotaxis and invasion, while STK39/SPAK regulates endothelial cell proliferation (PubMed:25362046). Also acts independently of the WNK1-SPAK/OSR1 kinase cascade by catalyzing phosphorylation of other substrates, such as SYT2, PCF11 and NEDD4L (PubMed:29196535). Mediates phosphorylation of SYT2, regulating SYT2 association with phospholipids and membrane-binding (By similarity). Regulates mRNA export in the nucleus by mediating phosphorylation of PCF11, thereby decreasing the association between PCF11 and POLR2A/RNA polymerase II and promoting mRNA export to the cytoplasm (PubMed:29196535). Acts as a negative regulator of autophagy (PubMed:27911840). Required for the abscission step during mitosis, independently of the WNK1-SPAK/OSR1 kinase cascade (PubMed:21220314). May also play a role in actin cytoskeletal reorganization (PubMed:10660600). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as SLC4A4, SLC26A6, SLC26A9, TRPV4 and CFTR (By similarity). Involved in the regulation of epithelial Na(+) channel (ENaC) by promoting activation of SGK1 in a kinase-independent manner: probably acts as a scaffold protein that promotes the recruitment of SGK1 to the mTORC2 complex in response to chloride, leading to mTORC2-dependent phosphorylation and activation of SGK1 (PubMed:36373794). Acts as an assembly factor for the ER membrane protein complex independently of its protein kinase activity: associates with EMC2 in the cytoplasm via its amphipathic alpha-helix, and prevents EMC2 ubiquitination and subsequent degradation, thereby promoting EMC2 stabilization (PubMed:33964204). {ECO:0000250|UniProtKB:P83741, ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:15883153, ECO:0000269|PubMed:16263722, ECO:0000269|PubMed:17190791, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:19739668, ECO:0000269|PubMed:21220314, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:25477473, ECO:0000269|PubMed:27911840, ECO:0000269|PubMed:29196535, ECO:0000269|PubMed:31656913, ECO:0000269|PubMed:33964204, ECO:0000269|PubMed:34289367, ECO:0000269|PubMed:36318922, ECO:0000269|PubMed:36373794}.; FUNCTION: [Isoform 3]: Kinase-defective isoform specifically expressed in kidney, which acts as a dominant-negative regulator of the longer isoform 1 (PubMed:14645531). Does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport (By similarity). Down-regulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity (By similarity). In kidney, may play an important role regulating sodium and potassium balance (By similarity). {ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:14645531}. |
Q9H4L4 | SENP3 | S212 | ochoa | Sentrin-specific protease 3 (EC 3.4.22.-) (SUMO-1-specific protease 3) (Sentrin/SUMO-specific protease SENP3) | Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates (PubMed:16608850, PubMed:32832608, PubMed:36050397). Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability (PubMed:15743823). Deconjugates SUMO2 and SUMO3 from CDCA8 (PubMed:18946085). Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300 (PubMed:19680224). Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1 (PubMed:19015314). Plays a role in the regulation of sumoylation status of ZNF148 (PubMed:18259216). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Deconjugates SUMO2 from KAT5 (PubMed:32832608). Catalyzes desumoylation of MRE11 (PubMed:36050397). {ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:16608850, ECO:0000269|PubMed:18259216, ECO:0000269|PubMed:18946085, ECO:0000269|PubMed:19015314, ECO:0000269|PubMed:19680224, ECO:0000269|PubMed:22872859, ECO:0000269|PubMed:32832608, ECO:0000269|PubMed:36050397}. |
Q9H5J8 | TAF1D | S234 | ochoa | TATA box-binding protein-associated factor RNA polymerase I subunit D (RNA polymerase I-specific TBP-associated factor 41 kDa) (TAFI41) (TATA box-binding protein-associated factor 1D) (TBP-associated factor 1D) (Transcription initiation factor SL1/TIF-IB subunit D) | Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. {ECO:0000269|PubMed:15970593, ECO:0000269|PubMed:17318177}. |
Q9H6U6 | BCAS3 | S894 | ochoa | BCAS3 microtubule associated cell migration factor (Breast carcinoma-amplified sequence 3) (GAOB1) | Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation (By similarity). Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin. Plays a regulatory role in autophagic activity. In complex with PHAF1, associates with the preautophagosomal structure during both non-selective and selective autophagy (PubMed:33499712). Probably binds phosphatidylinositol 3-phosphate (PtdIns3P) which would mediate the recruitment preautophagosomal structures (PubMed:33499712). {ECO:0000250|UniProtKB:Q8CCN5, ECO:0000269|PubMed:17505058, ECO:0000269|PubMed:33499712}. |
Q9H7N4 | SCAF1 | S161 | ochoa | Splicing factor, arginine/serine-rich 19 (SR-related C-terminal domain-associated factor 1) (SR-related and CTD-associated factor 1) (SR-related-CTD-associated factor) (SCAF) (Serine arginine-rich pre-mRNA splicing factor SR-A1) (SR-A1) | May function in pre-mRNA splicing. {ECO:0000250}. |
Q9HAU0 | PLEKHA5 | S937 | ochoa | Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2) | None |
Q9HBI1 | PARVB | S54 | ochoa | Beta-parvin (Affixin) | Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration. {ECO:0000269|PubMed:11402068, ECO:0000269|PubMed:15005707, ECO:0000269|PubMed:15159419, ECO:0000269|PubMed:15284246, ECO:0000269|PubMed:18325335}. |
Q9NQ86 | TRIM36 | S73 | ochoa | E3 ubiquitin-protein ligase TRIM36 (EC 2.3.2.27) (RING finger protein 98) (RING-type E3 ubiquitin transferase TRIM36) (Tripartite motif-containing protein 36) (Zinc-binding protein Rbcc728) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation (PubMed:28087737). May play a role in the acrosome reaction and fertilization. {ECO:0000250|UniProtKB:Q80WG7, ECO:0000269|PubMed:28087737}. |
Q9NQT8 | KIF13B | S1481 | ochoa | Kinesin-like protein KIF13B (Kinesin-like protein GAKIN) | Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes. {ECO:0000269|PubMed:20194617}. |
Q9NR45 | NANS | S248 | ochoa | N-acetylneuraminate-9-phosphate synthase (EC 2.5.1.57) (3-deoxy-D-glycero-D-galacto-nononate 9-phosphate synthase) (EC 2.5.1.132) (N-acetylneuraminic acid phosphate synthase) (NANS) (Sialic acid phosphate synthase) (Sialic acid synthase) | Catalyzes the condensation of phosphoenolpyruvate (PEP) and N-acetylmannosamine 6-phosphate (ManNAc-6-P) to synthesize N-acetylneuraminate-9-phosphate (Neu5Ac-9-P) (PubMed:10749855). Also catalyzes the condensation of PEP and D-mannose 6-phosphate (Man-6-P) to produce 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate (KDN-9-P) (PubMed:10749855). Neu5Ac-9-P and KDN-9-P are the phosphorylated forms of sialic acids N-acetylneuraminic acid (Neu5Ac) and deaminoneuraminic acid (KDN), respectively (PubMed:10749855). Required for brain and skeletal development (PubMed:27213289). {ECO:0000269|PubMed:10749855, ECO:0000269|PubMed:27213289}. |
Q9NRH3 | TUBG2 | S80 | ochoa|psp | Tubulin gamma-2 chain (Gamma-2-tubulin) | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685). Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:38305685). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685). {ECO:0000269|PubMed:38305685}. |
Q9NUW8 | TDP1 | S563 | psp | Tyrosyl-DNA phosphodiesterase 1 (Tyr-DNA phosphodiesterase 1) (EC 3.1.4.-) | DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate. {ECO:0000269|PubMed:12023295, ECO:0000269|PubMed:15111055, ECO:0000269|PubMed:15811850, ECO:0000269|PubMed:16141202, ECO:0000269|PubMed:22822062}. |
Q9NUY8 | TBC1D23 | S507 | ochoa | TBC1 domain family member 23 (HCV non-structural protein 4A-transactivated protein 1) | Putative Rab GTPase-activating protein which plays a role in vesicular trafficking (PubMed:28823707). Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles (PubMed:29084197, PubMed:29426865). Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP-1 (PubMed:29426865). Plays a role in brain development, including in cortical neuron positioning (By similarity). May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes that are essential for axonal and dendritic growth (By similarity). May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge (By similarity). {ECO:0000250|UniProtKB:Q8K0F1, ECO:0000269|PubMed:28823707, ECO:0000269|PubMed:29084197, ECO:0000269|PubMed:29426865}. |
Q9NVD7 | PARVA | S62 | ochoa | Alpha-parvin (Actopaxin) (CH-ILKBP) (Calponin-like integrin-linked kinase-binding protein) (Matrix-remodeling-associated protein 2) | Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishment of cell polarity, cell adhesion, cell spreading, and directed cell migration. Within the IPP (ILK-PINCH-PARVIN) complex, binds to F-actin, promoting F-actin bundling, a process required to generate force for actin cytoskeleton reorganization and subsequent dynamic cell adhesion events such as cell spreading and migration (PubMed:30367047). {ECO:0000250, ECO:0000269|PubMed:11134073, ECO:0000269|PubMed:11331308, ECO:0000269|PubMed:15284246, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:30367047}. |
Q9NYP3 | DONSON | S34 | ochoa | Protein downstream neighbor of Son (B17) | Replisome component that maintains genome stability by protecting stalled or damaged replication forks. After the induction of replication stress, required for the stabilization of stalled replication forks, the efficient activation of the intra-S-phase and G/2M cell-cycle checkpoints and the maintenance of genome stability. {ECO:0000269|PubMed:28191891}. |
Q9NYV4 | CDK12 | S440 | ochoa | Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12) | Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}. |
Q9NZ09 | UBAP1 | S250 | ochoa | Ubiquitin-associated protein 1 (UBAP-1) (Nasopharyngeal carcinoma-associated gene 20 protein) | Component of the ESCRT-I complex, a regulator of vesicular trafficking process (PubMed:21757351, PubMed:22405001, PubMed:31203368). Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) (PubMed:21757351, PubMed:22405001). Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2 (PubMed:22405001, PubMed:24284069, PubMed:31203368). {ECO:0000269|PubMed:21757351, ECO:0000269|PubMed:22405001, ECO:0000269|PubMed:24284069, ECO:0000269|PubMed:31203368}. |
Q9P0L9 | PKD2L1 | S685 | psp | Polycystin-2-like protein 1 (Polycystin-2L1) (Polycystic kidney disease 2-like 1 protein) (Polycystin-2 homolog) (Polycystin-L) (Polycystin-L1) | Homotetrameric, non-selective cation channel that is permeable to sodium, potassium, magnesium and calcium (PubMed:10517637, PubMed:11959145, PubMed:25820328, PubMed:27754867, PubMed:29425510, PubMed:30004384). Also forms functionnal heteromeric channels with PKD1, PKD1L1 and PKD1L3 (PubMed:23212381, PubMed:24336289). Pore-forming subunit of a heterotetrameric, non-selective cation channel, formed by PKD1L2 and PKD1L3, that is permeable to sodium, potassium, magnesium and calcium and which may act as a sour taste receptor in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect (PubMed:19812697, PubMed:23212381). The homomeric and heteromeric channels formed by PKD1L2 and PKD1L3 are activated by low pH and Ca(2+), but opens only when the extracellular pH rises again and after the removal of acid stimulus (PubMed:23212381). Pore-forming subunit of a calcium-permeant ion channel formed by PKD1L2 and PKD1L1 in primary cilia, where it controls cilium calcium concentration, without affecting cytoplasmic calcium concentration, and regulates sonic hedgehog/SHH signaling and GLI2 transcription (PubMed:24336289). The PKD1L1:PKD2L1 complex channel is mechanosensitive only at high pressures and is highly temperature sensitive (PubMed:24336289). Pore-forming subunit of a calcium-permeant ion channel formed by PKD1L2 and PKD1 that produces a transient increase in intracellular calcium concentration upon hypo-osmotic stimulation (200 mOsm) (By similarity). May play a role in the perception of carbonation taste (By similarity). May play a role in the sensory perception of water, via a mechanism that activates the channel in response to dilution of salivary bicarbonate and changes in salivary pH (By similarity). {ECO:0000250|UniProtKB:A2A259, ECO:0000269|PubMed:10517637, ECO:0000269|PubMed:11959145, ECO:0000269|PubMed:19812697, ECO:0000269|PubMed:23212381, ECO:0000269|PubMed:24336289, ECO:0000269|PubMed:25820328, ECO:0000269|PubMed:27754867, ECO:0000269|PubMed:29425510, ECO:0000269|PubMed:30004384}. |
Q9P107 | GMIP | S907 | ochoa | GEM-interacting protein (GMIP) | Stimulates, in vitro and in vivo, the GTPase activity of RhoA. {ECO:0000269|PubMed:12093360}. |
Q9P2G1 | ANKIB1 | S898 | ochoa | Ankyrin repeat and IBR domain-containing protein 1 (EC 2.3.2.31) | Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates. {ECO:0000250}. |
Q9UBC2 | EPS15L1 | S628 | ochoa | Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) | Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:9407958}. |
Q9UIJ5 | ZDHHC2 | S341 | ochoa | Palmitoyltransferase ZDHHC2 (EC 2.3.1.225) (Acyltransferase ZDHHC2) (EC 2.3.1.-) (Reduced expression associated with metastasis protein) (Ream) (Reduced expression in cancer protein) (Rec) (Zinc finger DHHC domain-containing protein 2) (DHHC-2) (Zinc finger protein 372) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes (PubMed:18296695, PubMed:18508921, PubMed:19144824, PubMed:21343290, PubMed:22034844, PubMed:23793055). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). In the nervous system, plays a role in long term synaptic potentiation by palmitoylating AKAP5 through which it regulates protein trafficking from the dendritic recycling endosomes to the plasma membrane and controls both structural and functional plasticity at excitatory synapses (By similarity). In dendrites, mediates the palmitoylation of DLG4 when synaptic activity decreases and induces synaptic clustering of DLG4 and associated AMPA-type glutamate receptors (By similarity). Also mediates the de novo and turnover palmitoylation of RGS7BP, a shuttle for Gi/o-specific GTPase-activating proteins/GAPs, promoting its localization to the plasma membrane in response to the activation of G protein-coupled receptors. Through the localization of these GTPase-activating proteins/GAPs, it also probably plays a role in G protein-coupled receptors signaling in neurons (By similarity). Also probably plays a role in cell adhesion by palmitoylating CD9 and CD151 to regulate their expression and function (PubMed:18508921). Palmitoylates the endoplasmic reticulum protein CKAP4 and regulates its localization to the plasma membrane (PubMed:18296695, PubMed:19144824). Could also palmitoylate LCK and regulate its localization to the plasma membrane (PubMed:22034844). {ECO:0000250|UniProtKB:P59267, ECO:0000250|UniProtKB:Q9JKR5, ECO:0000269|PubMed:18296695, ECO:0000269|PubMed:18508921, ECO:0000269|PubMed:19144824, ECO:0000269|PubMed:21343290, ECO:0000269|PubMed:22034844, ECO:0000269|PubMed:23793055}.; FUNCTION: (Microbial infection) Promotes Chikungunya virus (CHIKV) replication by mediating viral nsp1 palmitoylation. {ECO:0000269|PubMed:30404808}. |
Q9UJK0 | TSR3 | S228 | ochoa | 18S rRNA aminocarboxypropyltransferase (EC 2.5.1.157) (20S S rRNA accumulation protein 3 homolog) (HsTsr3) | Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1248 (Psi1248) in 18S rRNA (Probable). It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA (Probable). {ECO:0000305|PubMed:27084949}. |
Q9UKV3 | ACIN1 | S115 | ochoa | Apoptotic chromatin condensation inducer in the nucleus (Acinus) | Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}. |
Q9UKV3 | ACIN1 | S522 | ochoa | Apoptotic chromatin condensation inducer in the nucleus (Acinus) | Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}. |
Q9ULC8 | ZDHHC8 | S606 | ochoa | Palmitoyltransferase ZDHHC8 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 8) (DHHC-8) (Zinc finger protein 378) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (Probable). Through the palmitoylation of ABCA1 regulates the localization of the transporter to the plasma membrane and thereby regulates its function in cholesterol and phospholipid efflux (Probable). Could also pamitoylate the D(2) dopamine receptor DRD2 and regulate its stability and localization to the plasma membrane (Probable). Could also play a role in glutamatergic transmission (By similarity). {ECO:0000250|UniProtKB:Q5Y5T5, ECO:0000305|PubMed:19556522, ECO:0000305|PubMed:23034182, ECO:0000305|PubMed:26535572}.; FUNCTION: (Microbial infection) Able to palmitoylate SARS coronavirus-2/SARS-CoV-2 spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment. Once the virus has formed, spike palmitoylation controls fusion with the target cell. {ECO:0000269|PubMed:34599882}. |
Q9ULI0 | ATAD2B | S137 | ochoa | ATPase family AAA domain-containing protein 2B | None |
Q9ULJ3 | ZBTB21 | S415 | ochoa | Zinc finger and BTB domain-containing protein 21 (Zinc finger protein 295) | Acts as a transcription repressor. {ECO:0000269|PubMed:15629158}. |
Q9UMY1 | NOL7 | S126 | ochoa | U3 small nucleolar RNA-associated protein NOL7 (U3 snoRNA-associated protein NOL7) (Nucleolar protein 7) (Nucleolar protein of 27 kDa) | Functions as part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit that coordinates the first two steps of ribosome biogenesis in transcription of the primary transcript pre-RNA and pre-18S processing (PubMed:34516797, PubMed:37246770). During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). This subunit is required for processing of the 5'-external transcribed spacer sequence (5'ETS) of the primary transcript pre-rRNA to yield the 18S rRNA (PubMed:37246770). Also plays a role in maintaining early pre-rRNA levels, either by assisting in its transcription or stability (PubMed:37246770). {ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:37246770}. |
Q9UNK0 | STX8 | S96 | ochoa | Syntaxin-8 | Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER. |
Q9UPQ0 | LIMCH1 | S235 | ochoa | LIM and calponin homology domains-containing protein 1 | Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269|PubMed:28228547}. |
Q9UQ88 | CDK11A | S577 | ochoa | Cyclin-dependent kinase 11A (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 2) (Cell division protein kinase 11A) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L2) | Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression. {ECO:0000269|PubMed:12501247, ECO:0000269|PubMed:12624090}. |
Q9Y276 | BCS1L | S174 | ochoa | Mitochondrial chaperone BCS1 (h-BCS1) (EC 3.6.1.-) (BCS1-like protein) | Chaperone necessary for the incorporation of Rieske iron-sulfur protein UQCRFS1 into the mitochondrial respiratory chain complex III (PubMed:11528392, PubMed:9878253). Plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex (PubMed:18628306). {ECO:0000269|PubMed:11528392, ECO:0000269|PubMed:18628306, ECO:0000269|PubMed:9878253}. |
Q9Y2F5 | ICE1 | S1470 | ochoa | Little elongation complex subunit 1 (Interactor of little elongator complex ELL subunit 1) | Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780). {ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23932780}. |
Q9Y2K6 | USP20 | S105 | ochoa | Ubiquitin carboxyl-terminal hydrolase 20 (EC 3.4.19.12) (Deubiquitinating enzyme 20) (Ubiquitin thioesterase 20) (Ubiquitin-specific-processing protease 20) (VHL-interacting deubiquitinating enzyme 2) (hVDU2) | Deubiquitinating enzyme that plays a role in many cellular processes including autophagy, cellular antiviral response or membrane protein biogenesis (PubMed:27801882, PubMed:29487085). Attenuates TLR4-mediated NF-kappa-B signaling by cooperating with beta-arrestin-2/ARRB2 and inhibiting TRAF6 autoubiquitination (PubMed:26839314). Promotes cellular antiviral responses by deconjugating 'Lys-33' and 'Lys-48'-linked ubiquitination of STING1 leading to its stabilization (PubMed:27801882). Plays an essential role in autophagy induction by regulating the ULK1 stability through deubiquitination of ULK1 (PubMed:29487085). Acts as a positive regulator for NF-kappa-B activation by TNF-alpha through deubiquitinating 'Lys-48'-linked polyubiquitination of SQSTM1, leading to its increased stability (PubMed:32354117). Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2) (PubMed:19424180). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2 (PubMed:19424180). This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity (PubMed:15776016). Deubiquitinates MCL1, a pivotal member of the anti-apoptotic Bcl-2 protein family to regulate its stability (PubMed:35063767). Within the endoplasmic reticulum, participates with USP33 in the rescue of post-translationally targeted membrane proteins that are inappropriately ubiquitinated by the cytosolic protein quality control in the cytosol (PubMed:33792613). {ECO:0000269|PubMed:12056827, ECO:0000269|PubMed:12865408, ECO:0000269|PubMed:15776016, ECO:0000269|PubMed:19424180, ECO:0000269|PubMed:26839314, ECO:0000269|PubMed:27801882, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:32354117, ECO:0000269|PubMed:33792613, ECO:0000269|PubMed:35063767}. |
Q9Y2L6 | FRMD4B | S583 | ochoa | FERM domain-containing protein 4B (GRP1-binding protein GRSP1) | Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex. Plays a redundant role with FRMD4A in epithelial polarization. {ECO:0000250|UniProtKB:Q920B0}. |
Q9Y446 | PKP3 | S199 | ochoa | Plakophilin-3 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:24124604). Required for the localization of DSG2, DSP and PKP2 to mature desmosome junctions (PubMed:20859650). May also play a role in the maintenance of DSG3 protein abundance in keratinocytes (By similarity). Required for the formation of DSP-containing desmosome precursors in the cytoplasm during desmosome assembly (PubMed:25208567). Also regulates the accumulation of CDH1 to mature desmosome junctions, via cAMP-dependent signaling and its interaction with activated RAP1A (PubMed:25208567). Positively regulates the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with FXR1, may also regulate the protein abundance of DSP via the same mechanism (PubMed:25225333). May also regulate the protein abundance of the desmosome component PKP1 (By similarity). Required for the organization of desmosome junctions at intercellular borders between basal keratinocytes of the epidermis, as a result plays a role in maintenance of the dermal barrier and regulation of the dermal inflammatory response (By similarity). Required during epidermal keratinocyte differentiation for cell adherence at tricellular cell-cell contacts, via regulation of the timely formation of adherens junctions and desmosomes in a calcium-dependent manner, and may also play a role in the organization of the intracellular actin fiber belt (By similarity). Acts as a negative regulator of the inflammatory response in hematopoietic cells of the skin and intestine, via modulation of proinflammatory cytokine production (By similarity). Important for epithelial barrier maintenance in the intestine to reduce intestinal permeability, thereby plays a role in protection from intestinal-derived endotoxemia (By similarity). Required for the development of hair follicles, via a role in the regulation of inner root sheaf length, correct alignment and anterior-posterior polarity of hair follicles (By similarity). Promotes proliferation and cell-cycle G1/S phase transition of keratinocytes (By similarity). Promotes E2F1-driven transcription of G1/S phase promoting genes by acting to release E2F1 from its inhibitory interaction with RB1, via sequestering RB1 and CDKN1A to the cytoplasm and thereby increasing CDK4- and CDK6-driven phosphorylation of RB1 (By similarity). May act as a scaffold protein to facilitate MAPK phosphorylation of RPS6KA protein family members and subsequently promote downstream EGFR signaling (By similarity). May play a role in the positive regulation of transcription of Wnt-mediated TCF-responsive target genes (PubMed:34058472). {ECO:0000250|UniProtKB:Q9QY23, ECO:0000269|PubMed:20859650, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:34058472}. |
Q9Y4B4 | RAD54L2 | S1233 | ochoa | Helicase ARIP4 (EC 3.6.4.12) (Androgen receptor-interacting protein 4) (RAD54-like protein 2) | DNA helicase that modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. Not able to remodel mononucleosomes in vitro (By similarity). {ECO:0000250}. |
Q9Y4D2 | DAGLA | S847 | ochoa | Diacylglycerol lipase-alpha (DAGL-alpha) (DGL-alpha) (EC 3.1.1.116) (Neural stem cell-derived dendrite regulator) (Sn1-specific diacylglycerol lipase alpha) | Serine hydrolase that hydrolyzes arachidonic acid-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) (PubMed:14610053, PubMed:23502535, PubMed:26668358). Preferentially hydrolyzes sn-1 fatty acids from diacylglycerols (DAG) that contain arachidonic acid (AA) esterified at the sn-2 position to biosynthesize 2-AG (PubMed:14610053, PubMed:23502535, PubMed:26668358). Has negligible activity against other lipids including monoacylglycerols and phospholipids (PubMed:14610053). Plays a key role in regulating 2-AG signaling in the central nervous system (CNS). Regulates 2-AG involved in retrograde suppression at central synapses. Supports axonal growth during development and adult neurogenesis. Plays a role for eCB signaling in the physiological regulation of anxiety and depressive behaviors. Also regulates neuroinflammatory responses in the brain, in particular, LPS-induced microglial activation (By similarity). {ECO:0000250|UniProtKB:Q6WQJ1, ECO:0000269|PubMed:14610053, ECO:0000269|PubMed:23502535, ECO:0000269|PubMed:26668358}. |
Q9Y4G8 | RAPGEF2 | S579 | ochoa | Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1) | Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Also acts as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP (PubMed:23800469, PubMed:10801446) or not (PubMed:10548487, PubMed:10608844, PubMed:11359771). Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Also provides inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions. {ECO:0000269|PubMed:10548487, ECO:0000269|PubMed:10608844, ECO:0000269|PubMed:10608883, ECO:0000269|PubMed:10801446, ECO:0000269|PubMed:10934204, ECO:0000269|PubMed:11359771, ECO:0000269|PubMed:12391161, ECO:0000269|PubMed:16272156, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:23800469}. |
Q9Y4U1 | MMACHC | S247 | ochoa | Cyanocobalamin reductase / alkylcobalamin dealkylase (Alkylcobalamin:glutathione S-alkyltransferase) (EC 2.5.1.151) (CblC) (Cyanocobalamin reductase (cyanide-eliminating)) (EC 1.16.1.6) (Methylmalonic aciduria and homocystinuria type C protein) (MMACHC) | Cobalamin (vitamin B12) cytosolic chaperone that catalyzes the reductive decyanation of cyanocob(III)alamin (cyanocobalamin, CNCbl) to yield cob(II)alamin and cyanide, using FAD or FMN as cofactors and NADPH as cosubstrate (PubMed:18779575, PubMed:19700356, PubMed:21697092, PubMed:25809485). Cyanocobalamin constitutes the inactive form of vitamin B12 introduced from the diet, and is converted into the active cofactors methylcobalamin (MeCbl) involved in methionine biosynthesis, and 5'-deoxyadenosylcobalamin (AdoCbl) involved in the TCA cycle (PubMed:19801555). Forms a complex with the lysosomal transporter ABCD4 and its chaperone LMBRD1, to transport cobalamin across the lysosomal membrane into the cytosol (PubMed:25535791). The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR (methionine synthase) which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine (PubMed:21071249, PubMed:27771510). Also acts as a glutathione transferase by catalyzing the dealkylation of the alkylcob(III)alamins MeCbl and AdoCbl, using the thiolate of glutathione for nucleophilic displacement to generate cob(I)alamin and the corresponding glutathione thioether (PubMed:19801555, PubMed:21697092, PubMed:22642810, PubMed:25809485). The conversion of incoming MeCbl or AdoCbl into a common intermediate cob(I)alamin is necessary to meet the cellular needs for both cofactors (PubMed:19801555). Cysteine and homocysteine cannot substitute for glutathione in this reaction (PubMed:19801555). {ECO:0000269|PubMed:18779575, ECO:0000269|PubMed:19700356, ECO:0000269|PubMed:19801555, ECO:0000269|PubMed:21071249, ECO:0000269|PubMed:21697092, ECO:0000269|PubMed:22642810, ECO:0000269|PubMed:25809485, ECO:0000269|PubMed:27771510, ECO:0000303|PubMed:19801555, ECO:0000303|PubMed:25535791}. |
Q9Y5W7 | SNX14 | S734 | ochoa | Sorting nexin-14 | Plays a role in maintaining normal neuronal excitability and synaptic transmission. May be involved in several stages of intracellular trafficking (By similarity). Required for autophagosome clearance, possibly by mediating the fusion of lysosomes with autophagosomes (Probable). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2), a key component of late endosomes/lysosomes (PubMed:25848753). Does not bind phosphatidylinositol 3-phosphate (PtdIns(3P)) (PubMed:25148684, PubMed:25848753). {ECO:0000250|UniProtKB:Q8BHY8, ECO:0000269|PubMed:25148684, ECO:0000269|PubMed:25848753, ECO:0000305|PubMed:25848753}. |
Q9Y666 | SLC12A7 | S108 | ochoa | Solute carrier family 12 member 7 (Electroneutral potassium-chloride cotransporter 4) (K-Cl cotransporter 4) | Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:10913127). May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity). {ECO:0000250, ECO:0000269|PubMed:10913127}. |
Q9Y6Q9 | NCOA3 | S551 | ochoa | Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. |
P83731 | RPL24 | S38 | Sugiyama | Large ribosomal subunit protein eL24 (60S ribosomal protein L24) (60S ribosomal protein L30) | Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
Q15080 | NCF4 | S67 | Sugiyama | Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (SH3 and PX domain-containing protein 4) (p40-phox) (p40phox) | Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (Probable). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction (By similarity). Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane (By similarity). This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox (By similarity). {ECO:0000250|UniProtKB:P04839, ECO:0000250|UniProtKB:P14598, ECO:0000305|PubMed:8280052}. |
Q7Z4H3 | HDDC2 | S170 | Sugiyama | 5'-deoxynucleotidase HDDC2 (EC 3.1.3.89) (HD domain-containing protein 2) (Hepatitis C virus NS5A-transactivated protein 2) (HCV NS5A-transactivated protein 2) | Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP). {ECO:0000250|UniProtKB:P53144}. |
Q9P265 | DIP2B | S134 | Sugiyama | Disco-interacting protein 2 homolog B (DIP2 homolog B) | Negatively regulates axonal outgrowth and is essential for normal synaptic transmission. Not required for regulation of axon polarity. Promotes acetylation of alpha-tubulin. {ECO:0000250|UniProtKB:Q3UH60}. |
P47756 | CAPZB | S73 | Sugiyama | F-actin-capping protein subunit beta (CapZ beta) | F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:A9XFX6, ECO:0000269|PubMed:21834987}. |
Q96PZ0 | PUS7 | S53 | Sugiyama | Pseudouridylate synthase 7 homolog (EC 5.4.99.-) | Pseudouridylate synthase that catalyzes pseudouridylation of RNAs (PubMed:28073919, PubMed:29628141, PubMed:30778726, PubMed:31477916, PubMed:34718722, PubMed:35051350). Acts as a regulator of protein synthesis in embryonic stem cells by mediating pseudouridylation of RNA fragments derived from tRNAs (tRFs): pseudouridylated tRFs inhibit translation by targeting the translation initiation complex (PubMed:29628141). Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3' (PubMed:28073919, PubMed:31477916, PubMed:35051350). Acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions (PubMed:35051350). Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing (PubMed:35051350). In addition to mRNAs and tRNAs, binds other types of RNAs, such as snRNAs, Y RNAs and vault RNAs, suggesting that it can catalyze pseudouridylation of many RNA types (PubMed:29628141). {ECO:0000269|PubMed:28073919, ECO:0000269|PubMed:29628141, ECO:0000269|PubMed:30778726, ECO:0000269|PubMed:31477916, ECO:0000269|PubMed:34718722, ECO:0000269|PubMed:35051350}. |
P43403 | ZAP70 | S263 | Sugiyama | Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-chain associated protein) (Syk-related tyrosine kinase) | Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Also contributes to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD247/CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization to the stimulated TCR and to relieve its autoinhibited conformation. Release of ZAP70 active conformation is further stabilized by phosphorylation mediated by LCK. Subsequently, ZAP70 phosphorylates at least 2 essential adapter proteins: LAT and LCP2. In turn, a large number of signaling molecules are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation. Furthermore, ZAP70 controls cytoskeleton modifications, adhesion and mobility of T-lymphocytes, thus ensuring correct delivery of effectors to the APC. ZAP70 is also required for TCR-CD247/CD3Z internalization and degradation through interaction with the E3 ubiquitin-protein ligase CBL and adapter proteins SLA and SLA2. Thus, ZAP70 regulates both T-cell activation switch on and switch off by modulating TCR expression at the T-cell surface. During thymocyte development, ZAP70 promotes survival and cell-cycle progression of developing thymocytes before positive selection (when cells are still CD4/CD8 double negative). Additionally, ZAP70-dependent signaling pathway may also contribute to primary B-cells formation and activation through B-cell receptor (BCR). {ECO:0000269|PubMed:11353765, ECO:0000269|PubMed:12051764, ECO:0000269|PubMed:1423621, ECO:0000269|PubMed:20135127, ECO:0000269|PubMed:26903241, ECO:0000269|PubMed:38614099, ECO:0000269|PubMed:8124727, ECO:0000269|PubMed:8702662, ECO:0000269|PubMed:9489702}. |
Q13261 | IL15RA | Y227 | SIGNOR|iPTMNet|EPSD | Interleukin-15 receptor subunit alpha (IL-15 receptor subunit alpha) (IL-15R-alpha) (IL-15RA) (CD antigen CD215) [Cleaved into: Soluble interleukin-15 receptor subunit alpha (sIL-15 receptor subunit alpha) (sIL-15R-alpha) (sIL-15RA)] | High-affinity receptor for interleukin-15 (PubMed:8530383). Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells (By similarity). In neutrophils, binds and activates kinase SYK in response to IL15 stimulation (PubMed:15123770). In neutrophils, required for IL15-induced phagocytosis in a SYK-dependent manner (PubMed:15123770). Expression of different isoforms may alter or interfere with signal transduction (PubMed:10480910). {ECO:0000250|UniProtKB:Q60819, ECO:0000269|PubMed:10480910, ECO:0000269|PubMed:15123770, ECO:0000269|PubMed:8530383}.; FUNCTION: [Isoform 5]: Does not bind IL15. {ECO:0000269|PubMed:10480910}.; FUNCTION: [Isoform 6]: Does not bind IL15. {ECO:0000269|PubMed:10480910}.; FUNCTION: [Isoform 7]: Does not bind IL15. {ECO:0000269|PubMed:10480910}.; FUNCTION: [Isoform 8]: Does not bind IL15. {ECO:0000269|PubMed:10480910}. |
Q04760 | GLO1 | S114 | Sugiyama | Lactoylglutathione lyase (EC 4.4.1.5) (Aldoketomutase) (Glyoxalase I) (Glx I) (Ketone-aldehyde mutase) (Methylglyoxalase) (S-D-lactoylglutathione methylglyoxal lyase) | Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione (PubMed:20454679, PubMed:23122816, PubMed:9705294). Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B (PubMed:19199007). Required for normal osteoclastogenesis (By similarity). {ECO:0000250|UniProtKB:Q9CPU0, ECO:0000269|PubMed:19199007, ECO:0000269|PubMed:20454679, ECO:0000269|PubMed:23122816, ECO:0000269|PubMed:9705294}. |
P56645 | PER3 | S634 | SIGNOR|iPTMNet | Period circadian protein homolog 3 (hPER3) (Cell growth-inhibiting gene 13 protein) (Circadian clock protein PERIOD 3) | Originally described as a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1, NR1D2, RORA, RORB and RORG, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Has a redundant role with the other PER proteins PER1 and PER2 and is not essential for the circadian rhythms maintenance. In contrast, plays an important role in sleep-wake timing and sleep homeostasis probably through the transcriptional regulation of sleep homeostasis-related genes, without influencing circadian parameters. Can bind heme. {ECO:0000269|PubMed:17346965, ECO:0000269|PubMed:19716732, ECO:0000269|PubMed:24439663, ECO:0000269|PubMed:24577121, ECO:0000269|PubMed:26903630}. |
P49590 | HARS2 | S127 | Sugiyama | Histidine--tRNA ligase, mitochondrial (EC 6.1.1.21) (Histidine--tRNA ligase-like) (Histidyl-tRNA synthetase) (HisRS) | Mitochondrial aminoacyl-tRNA synthetase that catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). {ECO:0000269|PubMed:21464306}. |
Q13043 | STK4 | S288 | Sugiyama | Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)] | Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes. {ECO:0000250|UniProtKB:Q9JI11, ECO:0000269|PubMed:11278283, ECO:0000269|PubMed:11517310, ECO:0000269|PubMed:12757711, ECO:0000269|PubMed:15109305, ECO:0000269|PubMed:16510573, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:17932490, ECO:0000269|PubMed:18328708, ECO:0000269|PubMed:18986304, ECO:0000269|PubMed:19525978, ECO:0000269|PubMed:21212262, ECO:0000269|PubMed:21245099, ECO:0000269|PubMed:21512132, ECO:0000269|PubMed:8702870, ECO:0000269|PubMed:8816758}. |
P10636 | MAPT | S355 | SIGNOR | Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}. |
Q13164 | MAPK7 | S337 | Sugiyama | Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5) | Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via interaction with STUB1/CHIP and promotion of STUB1-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity). May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction. {ECO:0000250|UniProtKB:P0C865, ECO:0000269|PubMed:11254654, ECO:0000269|PubMed:11278431, ECO:0000269|PubMed:22869143, ECO:0000269|PubMed:9384584, ECO:0000269|PubMed:9790194}. |
Q6P0Q8 | MAST2 | S775 | Sugiyama | Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1) | Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}. |
Q8NE63 | HIPK4 | S298 | Sugiyama | Homeodomain-interacting protein kinase 4 (EC 2.7.11.1) | Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential). {ECO:0000250, ECO:0000305}. |
O43290 | SART1 | S624 | Sugiyama | U4/U6.U5 tri-snRNP-associated protein 1 (SNU66 homolog) (hSnu66) (Squamous cell carcinoma antigen recognized by T-cells 1) (SART-1) (hSART-1) (U4/U6.U5 tri-snRNP-associated 110 kDa protein) (allergen Hom s 1) | Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA. {ECO:0000269|PubMed:11350945, ECO:0000269|PubMed:25092792}. |
P83436 | COG7 | S559 | Sugiyama | Conserved oligomeric Golgi complex subunit 7 (COG complex subunit 7) (Component of oligomeric Golgi complex 7) | Required for normal Golgi function. {ECO:0000269|PubMed:11980916}. |
Q9NRA0 | SPHK2 | S377 | Sugiyama | Sphingosine kinase 2 (SK 2) (SPK 2) (EC 2.7.1.91) | Catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides (PubMed:12954646, PubMed:19168031). In contrast to prosurvival SPHK1, has a positive effect on intracellular ceramide levels, inhibits cells growth and enhances apoptosis (PubMed:16118219). In mitochondria, is important for cytochrome-c oxidase assembly and mitochondrial respiration. The SPP produced in mitochondria binds PHB2 and modulates the regulation via PHB2 of complex IV assembly and respiration (PubMed:20959514). In nucleus, plays a role in epigenetic regulation of gene expression. Interacts with HDAC1 and HDAC2 and, through SPP production, inhibits their enzymatic activity, preventing the removal of acetyl groups from lysine residues with histones. Up-regulates acetylation of histone H3-K9, histone H4-K5 and histone H2B-K12 (PubMed:19729656). In nucleus, may have an inhibitory effect on DNA synthesis and cell cycle (PubMed:12954646, PubMed:16103110). In mast cells, is the main regulator of SPP production which mediates calcium influx, NF-kappa-B activation, cytokine production, such as TNF and IL6, and degranulation of mast cells (By similarity). In dopaminergic neurons, is involved in promoting mitochondrial functions regulating ATP and ROS levels (By similarity). Also involved in the regulation of glucose and lipid metabolism (By similarity). {ECO:0000250|UniProtKB:Q9JIA7, ECO:0000269|PubMed:12954646, ECO:0000269|PubMed:16103110, ECO:0000269|PubMed:16118219, ECO:0000269|PubMed:19168031, ECO:0000269|PubMed:19729656, ECO:0000269|PubMed:20959514}. |
Q9NS15 | LTBP3 | S871 | Sugiyama | Latent-transforming growth factor beta-binding protein 3 (LTBP-3) | Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. {ECO:0000303|PubMed:10743502, ECO:0000303|PubMed:11104663}. |
Download
reactome_id | name | p | -log10_p |
---|---|---|---|
R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.000217 | 3.664 |
R-HSA-1963640 | GRB2 events in ERBB2 signaling | 0.000574 | 3.241 |
R-HSA-1250347 | SHC1 events in ERBB4 signaling | 0.000574 | 3.241 |
R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.000495 | 3.305 |
R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.000436 | 3.360 |
R-HSA-69278 | Cell Cycle, Mitotic | 0.000847 | 3.072 |
R-HSA-1253288 | Downregulation of ERBB4 signaling | 0.001043 | 2.982 |
R-HSA-1640170 | Cell Cycle | 0.001318 | 2.880 |
R-HSA-69275 | G2/M Transition | 0.001202 | 2.920 |
R-HSA-453274 | Mitotic G2-G2/M phases | 0.001297 | 2.887 |
R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.002008 | 2.697 |
R-HSA-74160 | Gene expression (Transcription) | 0.002454 | 2.610 |
R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 0.004176 | 2.379 |
R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.003422 | 2.466 |
R-HSA-380287 | Centrosome maturation | 0.003849 | 2.415 |
R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.004037 | 2.394 |
R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.003397 | 2.469 |
R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.004037 | 2.394 |
R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.003857 | 2.414 |
R-HSA-8941333 | RUNX2 regulates genes involved in differentiation of myeloid cells | 0.005203 | 2.284 |
R-HSA-6785631 | ERBB2 Regulates Cell Motility | 0.004849 | 2.314 |
R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.005215 | 2.283 |
R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.004561 | 2.341 |
R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.005338 | 2.273 |
R-HSA-211000 | Gene Silencing by RNA | 0.005635 | 2.249 |
R-HSA-8941284 | RUNX2 regulates chondrocyte maturation | 0.007001 | 2.155 |
R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.010102 | 1.996 |
R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 0.009039 | 2.044 |
R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.010842 | 1.965 |
R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.007132 | 2.147 |
R-HSA-198753 | ERK/MAPK targets | 0.011357 | 1.945 |
R-HSA-1227986 | Signaling by ERBB2 | 0.007574 | 2.121 |
R-HSA-199991 | Membrane Trafficking | 0.008374 | 2.077 |
R-HSA-9018519 | Estrogen-dependent gene expression | 0.006316 | 2.200 |
R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.007483 | 2.126 |
R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.009039 | 2.044 |
R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.008513 | 2.070 |
R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 0.011309 | 1.947 |
R-HSA-983189 | Kinesins | 0.007574 | 2.121 |
R-HSA-438064 | Post NMDA receptor activation events | 0.007642 | 2.117 |
R-HSA-2132295 | MHC class II antigen presentation | 0.011614 | 1.935 |
R-HSA-6807878 | COPI-mediated anterograde transport | 0.012513 | 1.903 |
R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.012513 | 1.903 |
R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.012952 | 1.888 |
R-HSA-69236 | G1 Phase | 0.014147 | 1.849 |
R-HSA-69231 | Cyclin D associated events in G1 | 0.014147 | 1.849 |
R-HSA-68877 | Mitotic Prometaphase | 0.013931 | 1.856 |
R-HSA-9022707 | MECP2 regulates transcription factors | 0.013801 | 1.860 |
R-HSA-8941332 | RUNX2 regulates genes involved in cell migration | 0.025837 | 1.588 |
R-HSA-202670 | ERKs are inactivated | 0.029323 | 1.533 |
R-HSA-1250342 | PI3K events in ERBB4 signaling | 0.029323 | 1.533 |
R-HSA-429947 | Deadenylation of mRNA | 0.016577 | 1.780 |
R-HSA-1236394 | Signaling by ERBB4 | 0.015877 | 1.799 |
R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.027659 | 1.558 |
R-HSA-428540 | Activation of RAC1 | 0.029323 | 1.533 |
R-HSA-2025928 | Calcineurin activates NFAT | 0.019422 | 1.712 |
R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 0.022934 | 1.640 |
R-HSA-162599 | Late Phase of HIV Life Cycle | 0.024651 | 1.608 |
R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.026291 | 1.580 |
R-HSA-2129379 | Molecules associated with elastic fibres | 0.028452 | 1.546 |
R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.021430 | 1.669 |
R-HSA-68886 | M Phase | 0.028202 | 1.550 |
R-HSA-8953854 | Metabolism of RNA | 0.017885 | 1.748 |
R-HSA-199977 | ER to Golgi Anterograde Transport | 0.028446 | 1.546 |
R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.017004 | 1.769 |
R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.028086 | 1.552 |
R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 0.029323 | 1.533 |
R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.024702 | 1.607 |
R-HSA-73857 | RNA Polymerase II Transcription | 0.018491 | 1.733 |
R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 0.016509 | 1.782 |
R-HSA-212436 | Generic Transcription Pathway | 0.019299 | 1.714 |
R-HSA-210747 | Regulation of gene expression in early pancreatic precursor cells | 0.025837 | 1.588 |
R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 0.016509 | 1.782 |
R-HSA-9620244 | Long-term potentiation | 0.018059 | 1.743 |
R-HSA-913531 | Interferon Signaling | 0.028687 | 1.542 |
R-HSA-9833482 | PKR-mediated signaling | 0.020788 | 1.682 |
R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.015933 | 1.798 |
R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.019951 | 1.700 |
R-HSA-9700206 | Signaling by ALK in cancer | 0.019951 | 1.700 |
R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.029857 | 1.525 |
R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.032984 | 1.482 |
R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 0.032488 | 1.488 |
R-HSA-8983432 | Interleukin-15 signaling | 0.032984 | 1.482 |
R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.032984 | 1.482 |
R-HSA-9930044 | Nuclear RNA decay | 0.032488 | 1.488 |
R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.033713 | 1.472 |
R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.030434 | 1.517 |
R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.033356 | 1.477 |
R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.033887 | 1.470 |
R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 0.034660 | 1.460 |
R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 0.034660 | 1.460 |
R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.034915 | 1.457 |
R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 0.036814 | 1.434 |
R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 0.036814 | 1.434 |
R-HSA-162587 | HIV Life Cycle | 0.037182 | 1.430 |
R-HSA-2559585 | Oncogene Induced Senescence | 0.039068 | 1.408 |
R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 0.040806 | 1.389 |
R-HSA-5653656 | Vesicle-mediated transport | 0.038408 | 1.416 |
R-HSA-9612973 | Autophagy | 0.036238 | 1.441 |
R-HSA-194138 | Signaling by VEGF | 0.039275 | 1.406 |
R-HSA-8939211 | ESR-mediated signaling | 0.040466 | 1.393 |
R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 0.040806 | 1.389 |
R-HSA-8848021 | Signaling by PTK6 | 0.038112 | 1.419 |
R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.038112 | 1.419 |
R-HSA-3359473 | Defective MMADHC causes MMAHCD | 0.051539 | 1.288 |
R-HSA-4549380 | Defective ALG1 causes CDG-1k | 0.051539 | 1.288 |
R-HSA-9632700 | Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding... | 0.051539 | 1.288 |
R-HSA-9630794 | Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4... | 0.051539 | 1.288 |
R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 0.068123 | 1.167 |
R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 0.068123 | 1.167 |
R-HSA-198765 | Signalling to ERK5 | 0.068123 | 1.167 |
R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 0.068123 | 1.167 |
R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 0.068123 | 1.167 |
R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 0.068123 | 1.167 |
R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 0.068123 | 1.167 |
R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 0.068123 | 1.167 |
R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 0.068123 | 1.167 |
R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 0.068123 | 1.167 |
R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 0.068123 | 1.167 |
R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 0.068123 | 1.167 |
R-HSA-3359474 | Defective MMACHC causes MAHCC | 0.084419 | 1.074 |
R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.084419 | 1.074 |
R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.084419 | 1.074 |
R-HSA-8941237 | Invadopodia formation | 0.084419 | 1.074 |
R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 0.131621 | 0.881 |
R-HSA-176417 | Phosphorylation of Emi1 | 0.131621 | 0.881 |
R-HSA-8849470 | PTK6 Regulates Cell Cycle | 0.131621 | 0.881 |
R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.049246 | 1.308 |
R-HSA-163767 | PP2A-mediated dephosphorylation of key metabolic factors | 0.161734 | 0.791 |
R-HSA-112412 | SOS-mediated signalling | 0.161734 | 0.791 |
R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.058254 | 1.235 |
R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.058254 | 1.235 |
R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 0.176398 | 0.754 |
R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.077778 | 1.109 |
R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.077778 | 1.109 |
R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.218873 | 0.660 |
R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.218873 | 0.660 |
R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.218873 | 0.660 |
R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 0.093563 | 1.029 |
R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 0.099015 | 1.004 |
R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 0.232541 | 0.634 |
R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.232541 | 0.634 |
R-HSA-5339716 | Signaling by GSK3beta mutants | 0.232541 | 0.634 |
R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 0.245970 | 0.609 |
R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.245970 | 0.609 |
R-HSA-3656237 | Defective EXT2 causes exostoses 2 | 0.245970 | 0.609 |
R-HSA-179812 | GRB2 events in EGFR signaling | 0.245970 | 0.609 |
R-HSA-3656253 | Defective EXT1 causes exostoses 1, TRPS2 and CHDS | 0.245970 | 0.609 |
R-HSA-3000484 | Scavenging by Class F Receptors | 0.245970 | 0.609 |
R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.245970 | 0.609 |
R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.245970 | 0.609 |
R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.245970 | 0.609 |
R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.245970 | 0.609 |
R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 0.127483 | 0.895 |
R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.133388 | 0.875 |
R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.139354 | 0.856 |
R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.139354 | 0.856 |
R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 0.284870 | 0.545 |
R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.284870 | 0.545 |
R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.151452 | 0.820 |
R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.151452 | 0.820 |
R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.090968 | 1.041 |
R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.157577 | 0.803 |
R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.169960 | 0.770 |
R-HSA-383280 | Nuclear Receptor transcription pathway | 0.067253 | 1.172 |
R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.195170 | 0.710 |
R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.086414 | 1.063 |
R-HSA-141424 | Amplification of signal from the kinetochores | 0.086414 | 1.063 |
R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.201546 | 0.696 |
R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.201546 | 0.696 |
R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.201546 | 0.696 |
R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.131651 | 0.881 |
R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.131651 | 0.881 |
R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 0.207946 | 0.682 |
R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.214367 | 0.669 |
R-HSA-167161 | HIV Transcription Initiation | 0.214367 | 0.669 |
R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.214367 | 0.669 |
R-HSA-8854518 | AURKA Activation by TPX2 | 0.143693 | 0.843 |
R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.227261 | 0.643 |
R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.240208 | 0.619 |
R-HSA-774815 | Nucleosome assembly | 0.240208 | 0.619 |
R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.240208 | 0.619 |
R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 0.253189 | 0.597 |
R-HSA-69618 | Mitotic Spindle Checkpoint | 0.134678 | 0.871 |
R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.163832 | 0.786 |
R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.285675 | 0.544 |
R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.292162 | 0.534 |
R-HSA-72649 | Translation initiation complex formation | 0.298641 | 0.525 |
R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.264187 | 0.578 |
R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.209435 | 0.679 |
R-HSA-1643713 | Signaling by EGFR in Cancer | 0.110174 | 0.958 |
R-HSA-167172 | Transcription of the HIV genome | 0.151916 | 0.818 |
R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.046818 | 1.330 |
R-HSA-8941326 | RUNX2 regulates bone development | 0.176212 | 0.754 |
R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.235346 | 0.628 |
R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.235346 | 0.628 |
R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.099592 | 1.002 |
R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.121643 | 0.915 |
R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 0.195170 | 0.710 |
R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.201546 | 0.696 |
R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.292162 | 0.534 |
R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.116190 | 0.935 |
R-HSA-9656223 | Signaling by RAF1 mutants | 0.214367 | 0.669 |
R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.235346 | 0.628 |
R-HSA-354192 | Integrin signaling | 0.151452 | 0.820 |
R-HSA-1221632 | Meiotic synapsis | 0.094417 | 1.025 |
R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 0.182500 | 0.739 |
R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.195170 | 0.710 |
R-HSA-167169 | HIV Transcription Elongation | 0.201546 | 0.696 |
R-HSA-9603505 | NTRK3 as a dependence receptor | 0.051539 | 1.288 |
R-HSA-203641 | NOSTRIN mediated eNOS trafficking | 0.161734 | 0.791 |
R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.053682 | 1.270 |
R-HSA-190873 | Gap junction degradation | 0.190806 | 0.719 |
R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 0.245970 | 0.609 |
R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.115872 | 0.936 |
R-HSA-5673000 | RAF activation | 0.163747 | 0.786 |
R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.240208 | 0.619 |
R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 0.232541 | 0.634 |
R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.245970 | 0.609 |
R-HSA-4641265 | Repression of WNT target genes | 0.245970 | 0.609 |
R-HSA-9649948 | Signaling downstream of RAS mutants | 0.246696 | 0.608 |
R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.246696 | 0.608 |
R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.246696 | 0.608 |
R-HSA-73864 | RNA Polymerase I Transcription | 0.195038 | 0.710 |
R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.277719 | 0.556 |
R-HSA-5693606 | DNA Double Strand Break Response | 0.147785 | 0.830 |
R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.177423 | 0.751 |
R-HSA-5693607 | Processing of DNA double-strand break ends | 0.208521 | 0.681 |
R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.186175 | 0.730 |
R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 0.131621 | 0.881 |
R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.044952 | 1.347 |
R-HSA-163754 | Insulin effects increased synthesis of Xylulose-5-Phosphate | 0.161734 | 0.791 |
R-HSA-389977 | Post-chaperonin tubulin folding pathway | 0.072723 | 1.138 |
R-HSA-113418 | Formation of the Early Elongation Complex | 0.121643 | 0.915 |
R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 0.139354 | 0.856 |
R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.182500 | 0.739 |
R-HSA-5674135 | MAP2K and MAPK activation | 0.214367 | 0.669 |
R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.220806 | 0.656 |
R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.266186 | 0.575 |
R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.204003 | 0.690 |
R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.163832 | 0.786 |
R-HSA-1295596 | Spry regulation of FGF signaling | 0.284870 | 0.545 |
R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.168789 | 0.773 |
R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.163747 | 0.786 |
R-HSA-2467813 | Separation of Sister Chromatids | 0.105364 | 0.977 |
R-HSA-212165 | Epigenetic regulation of gene expression | 0.261403 | 0.583 |
R-HSA-72613 | Eukaryotic Translation Initiation | 0.198595 | 0.702 |
R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.110174 | 0.958 |
R-HSA-72737 | Cap-dependent Translation Initiation | 0.198595 | 0.702 |
R-HSA-174577 | Activation of C3 and C5 | 0.116163 | 0.935 |
R-HSA-426486 | Small interfering RNA (siRNA) biogenesis | 0.146810 | 0.833 |
R-HSA-8851805 | MET activates RAS signaling | 0.245970 | 0.609 |
R-HSA-6811438 | Intra-Golgi traffic | 0.056818 | 1.246 |
R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.121643 | 0.915 |
R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.160284 | 0.795 |
R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.161707 | 0.791 |
R-HSA-5693532 | DNA Double-Strand Break Repair | 0.186513 | 0.729 |
R-HSA-74749 | Signal attenuation | 0.204963 | 0.688 |
R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.054082 | 1.267 |
R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.164520 | 0.784 |
R-HSA-1500620 | Meiosis | 0.226805 | 0.644 |
R-HSA-6802949 | Signaling by RAS mutants | 0.246696 | 0.608 |
R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.189507 | 0.722 |
R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.062955 | 1.201 |
R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.222204 | 0.653 |
R-HSA-68882 | Mitotic Anaphase | 0.126720 | 0.897 |
R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.128707 | 0.890 |
R-HSA-9630750 | Evasion of Oncogene Induced Senescence Due to p16INK4A Defects | 0.051539 | 1.288 |
R-HSA-9632693 | Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects | 0.051539 | 1.288 |
R-HSA-446343 | Localization of the PINCH-ILK-PARVIN complex to focal adhesions | 0.068123 | 1.167 |
R-HSA-8875513 | MET interacts with TNS proteins | 0.084419 | 1.074 |
R-HSA-9754119 | Drug-mediated inhibition of CDK4/CDK6 activity | 0.100430 | 0.998 |
R-HSA-446353 | Cell-extracellular matrix interactions | 0.044952 | 1.347 |
R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 0.058254 | 1.235 |
R-HSA-196025 | Formation of annular gap junctions | 0.176398 | 0.754 |
R-HSA-9762292 | Regulation of CDH11 function | 0.204963 | 0.688 |
R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 0.204963 | 0.688 |
R-HSA-9034864 | Activated NTRK3 signals through RAS | 0.218873 | 0.660 |
R-HSA-192905 | vRNP Assembly | 0.218873 | 0.660 |
R-HSA-4839744 | Signaling by APC mutants | 0.218873 | 0.660 |
R-HSA-75896 | Plasmalogen biosynthesis | 0.232541 | 0.634 |
R-HSA-9026519 | Activated NTRK2 signals through RAS | 0.232541 | 0.634 |
R-HSA-4839735 | Signaling by AXIN mutants | 0.232541 | 0.634 |
R-HSA-4839748 | Signaling by AMER1 mutants | 0.232541 | 0.634 |
R-HSA-203927 | MicroRNA (miRNA) biogenesis | 0.104553 | 0.981 |
R-HSA-174490 | Membrane binding and targetting of GAG proteins | 0.259166 | 0.586 |
R-HSA-162588 | Budding and maturation of HIV virion | 0.139354 | 0.856 |
R-HSA-180336 | SHC1 events in EGFR signaling | 0.284870 | 0.545 |
R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.071815 | 1.144 |
R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.182500 | 0.739 |
R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.240208 | 0.619 |
R-HSA-5620924 | Intraflagellar transport | 0.259687 | 0.586 |
R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.169960 | 0.770 |
R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.220806 | 0.656 |
R-HSA-3000170 | Syndecan interactions | 0.093563 | 1.029 |
R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 0.220806 | 0.656 |
R-HSA-72312 | rRNA processing | 0.160342 | 0.795 |
R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 0.188820 | 0.724 |
R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 0.161734 | 0.791 |
R-HSA-9646399 | Aggrephagy | 0.051413 | 1.289 |
R-HSA-2428933 | SHC-related events triggered by IGF1R | 0.245970 | 0.609 |
R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 0.272131 | 0.565 |
R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.284870 | 0.545 |
R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.157577 | 0.803 |
R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.127720 | 0.894 |
R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.168789 | 0.773 |
R-HSA-912446 | Meiotic recombination | 0.279182 | 0.554 |
R-HSA-391251 | Protein folding | 0.268917 | 0.570 |
R-HSA-9609646 | HCMV Infection | 0.202429 | 0.694 |
R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.131651 | 0.881 |
R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.060704 | 1.217 |
R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.182500 | 0.739 |
R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.192517 | 0.716 |
R-HSA-9630747 | Diseases of Cellular Senescence | 0.068123 | 1.167 |
R-HSA-9675132 | Diseases of cellular response to stress | 0.068123 | 1.167 |
R-HSA-190872 | Transport of connexons to the plasma membrane | 0.062955 | 1.201 |
R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 0.067780 | 1.169 |
R-HSA-1433617 | Regulation of signaling by NODAL | 0.190806 | 0.719 |
R-HSA-2179392 | EGFR Transactivation by Gastrin | 0.204963 | 0.688 |
R-HSA-426048 | Arachidonate production from DAG | 0.204963 | 0.688 |
R-HSA-1236973 | Cross-presentation of particulate exogenous antigens (phagosomes) | 0.204963 | 0.688 |
R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 0.232541 | 0.634 |
R-HSA-9615710 | Late endosomal microautophagy | 0.127483 | 0.895 |
R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.133388 | 0.875 |
R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.272131 | 0.565 |
R-HSA-177504 | Retrograde neurotrophin signalling | 0.272131 | 0.565 |
R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.222204 | 0.653 |
R-HSA-162906 | HIV Infection | 0.149427 | 0.826 |
R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.224143 | 0.649 |
R-HSA-68875 | Mitotic Prophase | 0.213086 | 0.671 |
R-HSA-5673001 | RAF/MAP kinase cascade | 0.099368 | 1.003 |
R-HSA-5655302 | Signaling by FGFR1 in disease | 0.214367 | 0.669 |
R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.112439 | 0.949 |
R-HSA-190828 | Gap junction trafficking | 0.065407 | 1.184 |
R-HSA-9766229 | Degradation of CDH1 | 0.266186 | 0.575 |
R-HSA-9733709 | Cardiogenesis | 0.151452 | 0.820 |
R-HSA-1566948 | Elastic fibre formation | 0.046272 | 1.335 |
R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.109839 | 0.959 |
R-HSA-1963642 | PI3K events in ERBB2 signaling | 0.058254 | 1.235 |
R-HSA-8934903 | Receptor Mediated Mitophagy | 0.204963 | 0.688 |
R-HSA-9028731 | Activated NTRK2 signals through FRS2 and FRS3 | 0.245970 | 0.609 |
R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.127483 | 0.895 |
R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 0.272131 | 0.565 |
R-HSA-9673770 | Signaling by PDGFRA extracellular domain mutants | 0.284870 | 0.545 |
R-HSA-9673767 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 0.284870 | 0.545 |
R-HSA-180746 | Nuclear import of Rev protein | 0.163747 | 0.786 |
R-HSA-6784531 | tRNA processing in the nucleus | 0.127720 | 0.894 |
R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.151452 | 0.820 |
R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.076530 | 1.116 |
R-HSA-5654743 | Signaling by FGFR4 | 0.227261 | 0.643 |
R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.173091 | 0.762 |
R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.082939 | 1.081 |
R-HSA-390466 | Chaperonin-mediated protein folding | 0.240713 | 0.618 |
R-HSA-9610379 | HCMV Late Events | 0.198588 | 0.702 |
R-HSA-379724 | tRNA Aminoacylation | 0.119989 | 0.921 |
R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.166069 | 0.780 |
R-HSA-5654741 | Signaling by FGFR3 | 0.240208 | 0.619 |
R-HSA-451927 | Interleukin-2 family signaling | 0.201546 | 0.696 |
R-HSA-9708296 | tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis | 0.068123 | 1.167 |
R-HSA-426117 | Cation-coupled Chloride cotransporters | 0.161734 | 0.791 |
R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 0.190806 | 0.719 |
R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 0.204963 | 0.688 |
R-HSA-166208 | mTORC1-mediated signalling | 0.088203 | 1.055 |
R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.232541 | 0.634 |
R-HSA-157858 | Gap junction trafficking and regulation | 0.080948 | 1.092 |
R-HSA-9027284 | Erythropoietin activates RAS | 0.284870 | 0.545 |
R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.297387 | 0.527 |
R-HSA-9634600 | Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | 0.297387 | 0.527 |
R-HSA-9682385 | FLT3 signaling in disease | 0.176212 | 0.754 |
R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.201546 | 0.696 |
R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.201546 | 0.696 |
R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.207946 | 0.682 |
R-HSA-69473 | G2/M DNA damage checkpoint | 0.177423 | 0.751 |
R-HSA-909733 | Interferon alpha/beta signaling | 0.195020 | 0.710 |
R-HSA-5683057 | MAPK family signaling cascades | 0.063092 | 1.200 |
R-HSA-5675221 | Negative regulation of MAPK pathway | 0.214367 | 0.669 |
R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.098848 | 1.005 |
R-HSA-1632852 | Macroautophagy | 0.063003 | 1.201 |
R-HSA-3214841 | PKMTs methylate histone lysines | 0.054082 | 1.267 |
R-HSA-2559583 | Cellular Senescence | 0.142431 | 0.846 |
R-HSA-9909396 | Circadian clock | 0.265824 | 0.575 |
R-HSA-9762293 | Regulation of CDH11 gene transcription | 0.190806 | 0.719 |
R-HSA-437239 | Recycling pathway of L1 | 0.074553 | 1.128 |
R-HSA-69206 | G1/S Transition | 0.235346 | 0.628 |
R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.048809 | 1.312 |
R-HSA-9758919 | Epithelial-Mesenchymal Transition (EMT) during gastrulation | 0.131621 | 0.881 |
R-HSA-9764302 | Regulation of CDH19 Expression and Function | 0.131621 | 0.881 |
R-HSA-5336415 | Uptake and function of diphtheria toxin | 0.161734 | 0.791 |
R-HSA-9834752 | Respiratory syncytial virus genome replication | 0.190806 | 0.719 |
R-HSA-9865881 | Complex III assembly | 0.099015 | 1.004 |
R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.259166 | 0.586 |
R-HSA-9675126 | Diseases of mitotic cell cycle | 0.145376 | 0.838 |
R-HSA-174362 | Transport and metabolism of PAPS | 0.284870 | 0.545 |
R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.188820 | 0.724 |
R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.195170 | 0.710 |
R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.246696 | 0.608 |
R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.170600 | 0.768 |
R-HSA-166166 | MyD88-independent TLR4 cascade | 0.170600 | 0.768 |
R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.236061 | 0.627 |
R-HSA-69620 | Cell Cycle Checkpoints | 0.121595 | 0.915 |
R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.153870 | 0.813 |
R-HSA-190861 | Gap junction assembly | 0.163747 | 0.786 |
R-HSA-162582 | Signal Transduction | 0.191781 | 0.717 |
R-HSA-4839726 | Chromatin organization | 0.199985 | 0.699 |
R-HSA-1483249 | Inositol phosphate metabolism | 0.177465 | 0.751 |
R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 0.259166 | 0.586 |
R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 0.297387 | 0.527 |
R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.195170 | 0.710 |
R-HSA-9006931 | Signaling by Nuclear Receptors | 0.237647 | 0.624 |
R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.130960 | 0.883 |
R-HSA-389356 | Co-stimulation by CD28 | 0.259687 | 0.586 |
R-HSA-73929 | Base-Excision Repair, AP Site Formation | 0.298641 | 0.525 |
R-HSA-8877330 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | 0.259166 | 0.586 |
R-HSA-110329 | Cleavage of the damaged pyrimidine | 0.220806 | 0.656 |
R-HSA-73928 | Depyrimidination | 0.220806 | 0.656 |
R-HSA-9033500 | TYSND1 cleaves peroxisomal proteins | 0.131621 | 0.881 |
R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 0.204963 | 0.688 |
R-HSA-210990 | PECAM1 interactions | 0.218873 | 0.660 |
R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 0.284870 | 0.545 |
R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.163747 | 0.786 |
R-HSA-9663891 | Selective autophagy | 0.094214 | 1.026 |
R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.231424 | 0.636 |
R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.205803 | 0.687 |
R-HSA-168898 | Toll-like Receptor Cascades | 0.169212 | 0.772 |
R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.171816 | 0.765 |
R-HSA-3247509 | Chromatin modifying enzymes | 0.292888 | 0.533 |
R-HSA-168255 | Influenza Infection | 0.272452 | 0.565 |
R-HSA-1483255 | PI Metabolism | 0.051383 | 1.289 |
R-HSA-9834899 | Specification of the neural plate border | 0.067780 | 1.169 |
R-HSA-5655291 | Signaling by FGFR4 in disease | 0.272131 | 0.565 |
R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 0.161734 | 0.791 |
R-HSA-1433559 | Regulation of KIT signaling | 0.272131 | 0.565 |
R-HSA-1169408 | ISG15 antiviral mechanism | 0.060704 | 1.217 |
R-HSA-8853659 | RET signaling | 0.176212 | 0.754 |
R-HSA-450294 | MAP kinase activation | 0.123832 | 0.907 |
R-HSA-8953897 | Cellular responses to stimuli | 0.060974 | 1.215 |
R-HSA-2262752 | Cellular responses to stress | 0.072657 | 1.139 |
R-HSA-1266738 | Developmental Biology | 0.242284 | 0.616 |
R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 0.297387 | 0.527 |
R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 0.297387 | 0.527 |
R-HSA-166520 | Signaling by NTRKs | 0.075770 | 1.121 |
R-HSA-446203 | Asparagine N-linked glycosylation | 0.258433 | 0.588 |
R-HSA-448424 | Interleukin-17 signaling | 0.160284 | 0.795 |
R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.093563 | 1.029 |
R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.110174 | 0.958 |
R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.245970 | 0.609 |
R-HSA-8963896 | HDL assembly | 0.272131 | 0.565 |
R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.051519 | 1.288 |
R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.054512 | 1.264 |
R-HSA-5633007 | Regulation of TP53 Activity | 0.097467 | 1.011 |
R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.176398 | 0.754 |
R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.190806 | 0.719 |
R-HSA-9842663 | Signaling by LTK | 0.245970 | 0.609 |
R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.169960 | 0.770 |
R-HSA-6804757 | Regulation of TP53 Degradation | 0.176212 | 0.754 |
R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.110888 | 0.955 |
R-HSA-9006936 | Signaling by TGFB family members | 0.207817 | 0.682 |
R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.180932 | 0.742 |
R-HSA-9607240 | FLT3 Signaling | 0.054082 | 1.267 |
R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.191466 | 0.718 |
R-HSA-373760 | L1CAM interactions | 0.082099 | 1.086 |
R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.062480 | 1.204 |
R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.125476 | 0.901 |
R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.214367 | 0.669 |
R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.195170 | 0.710 |
R-HSA-9694548 | Maturation of spike protein | 0.207946 | 0.682 |
R-HSA-422475 | Axon guidance | 0.130313 | 0.885 |
R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.110174 | 0.958 |
R-HSA-417957 | P2Y receptors | 0.272131 | 0.565 |
R-HSA-186712 | Regulation of beta-cell development | 0.116190 | 0.935 |
R-HSA-9675108 | Nervous system development | 0.116523 | 0.934 |
R-HSA-9008059 | Interleukin-37 signaling | 0.133388 | 0.875 |
R-HSA-165159 | MTOR signalling | 0.220806 | 0.656 |
R-HSA-1280215 | Cytokine Signaling in Immune system | 0.113197 | 0.946 |
R-HSA-75153 | Apoptotic execution phase | 0.071444 | 1.146 |
R-HSA-9711123 | Cellular response to chemical stress | 0.248259 | 0.605 |
R-HSA-75205 | Dissolution of Fibrin Clot | 0.218873 | 0.660 |
R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 0.082939 | 1.081 |
R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.233729 | 0.631 |
R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.228295 | 0.642 |
R-HSA-381038 | XBP1(S) activates chaperone genes | 0.088978 | 1.051 |
R-HSA-5357801 | Programmed Cell Death | 0.208788 | 0.680 |
R-HSA-381070 | IRE1alpha activates chaperones | 0.105110 | 0.978 |
R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.259687 | 0.586 |
R-HSA-381119 | Unfolded Protein Response (UPR) | 0.296975 | 0.527 |
R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.302251 | 0.520 |
R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.302251 | 0.520 |
R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.302251 | 0.520 |
R-HSA-5617833 | Cilium Assembly | 0.309684 | 0.509 |
R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.309685 | 0.509 |
R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.309685 | 0.509 |
R-HSA-3560783 | Defective B4GALT7 causes EDS, progeroid type | 0.309685 | 0.509 |
R-HSA-4420332 | Defective B3GALT6 causes EDSP2 and SEMDJL1 | 0.309685 | 0.509 |
R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.309685 | 0.509 |
R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.309685 | 0.509 |
R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 0.309685 | 0.509 |
R-HSA-9675151 | Disorders of Developmental Biology | 0.309685 | 0.509 |
R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.311570 | 0.506 |
R-HSA-5654736 | Signaling by FGFR1 | 0.311570 | 0.506 |
R-HSA-177929 | Signaling by EGFR | 0.311570 | 0.506 |
R-HSA-193648 | NRAGE signals death through JNK | 0.311570 | 0.506 |
R-HSA-70171 | Glycolysis | 0.311821 | 0.506 |
R-HSA-8856828 | Clathrin-mediated endocytosis | 0.316673 | 0.499 |
R-HSA-9764561 | Regulation of CDH1 Function | 0.318016 | 0.498 |
R-HSA-2980766 | Nuclear Envelope Breakdown | 0.318016 | 0.498 |
R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.318016 | 0.498 |
R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.321769 | 0.492 |
R-HSA-3560801 | Defective B3GAT3 causes JDSSDHD | 0.321769 | 0.492 |
R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 0.321769 | 0.492 |
R-HSA-2028269 | Signaling by Hippo | 0.321769 | 0.492 |
R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 0.321769 | 0.492 |
R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.324449 | 0.489 |
R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.324449 | 0.489 |
R-HSA-9609690 | HCMV Early Events | 0.330295 | 0.481 |
R-HSA-194441 | Metabolism of non-coding RNA | 0.330865 | 0.480 |
R-HSA-191859 | snRNP Assembly | 0.330865 | 0.480 |
R-HSA-9860931 | Response of endothelial cells to shear stress | 0.330980 | 0.480 |
R-HSA-9613829 | Chaperone Mediated Autophagy | 0.333642 | 0.477 |
R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.333642 | 0.477 |
R-HSA-3928664 | Ephrin signaling | 0.333642 | 0.477 |
R-HSA-210993 | Tie2 Signaling | 0.333642 | 0.477 |
R-HSA-432142 | Platelet sensitization by LDL | 0.333642 | 0.477 |
R-HSA-418038 | Nucleotide-like (purinergic) receptors | 0.333642 | 0.477 |
R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.333642 | 0.477 |
R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.335770 | 0.474 |
R-HSA-5619507 | Activation of HOX genes during differentiation | 0.335770 | 0.474 |
R-HSA-69242 | S Phase | 0.336478 | 0.473 |
R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.337264 | 0.472 |
R-HSA-9758941 | Gastrulation | 0.340447 | 0.468 |
R-HSA-168325 | Viral Messenger RNA Synthesis | 0.343646 | 0.464 |
R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 0.345308 | 0.462 |
R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.345308 | 0.462 |
R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.345308 | 0.462 |
R-HSA-429958 | mRNA decay by 3' to 5' exoribonuclease | 0.345308 | 0.462 |
R-HSA-113510 | E2F mediated regulation of DNA replication | 0.345308 | 0.462 |
R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 0.345308 | 0.462 |
R-HSA-727802 | Transport of nucleotide sugars | 0.345308 | 0.462 |
R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.348388 | 0.458 |
R-HSA-1268020 | Mitochondrial protein import | 0.350007 | 0.456 |
R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.350007 | 0.456 |
R-HSA-9707616 | Heme signaling | 0.350007 | 0.456 |
R-HSA-376176 | Signaling by ROBO receptors | 0.354501 | 0.450 |
R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.354905 | 0.450 |
R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.356347 | 0.448 |
R-HSA-373755 | Semaphorin interactions | 0.356347 | 0.448 |
R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.356771 | 0.448 |
R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.356771 | 0.448 |
R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.356771 | 0.448 |
R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.356771 | 0.448 |
R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.356771 | 0.448 |
R-HSA-389513 | Co-inhibition by CTLA4 | 0.356771 | 0.448 |
R-HSA-1362409 | Mitochondrial iron-sulfur cluster biogenesis | 0.356771 | 0.448 |
R-HSA-8848584 | Wax and plasmalogen biosynthesis | 0.356771 | 0.448 |
R-HSA-1181150 | Signaling by NODAL | 0.356771 | 0.448 |
R-HSA-445144 | Signal transduction by L1 | 0.356771 | 0.448 |
R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.356771 | 0.448 |
R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.359680 | 0.444 |
R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.368033 | 0.434 |
R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.368033 | 0.434 |
R-HSA-5654704 | SHC-mediated cascade:FGFR3 | 0.368033 | 0.434 |
R-HSA-167044 | Signalling to RAS | 0.368033 | 0.434 |
R-HSA-422085 | Synthesis, secretion, and deacylation of Ghrelin | 0.368033 | 0.434 |
R-HSA-210991 | Basigin interactions | 0.368033 | 0.434 |
R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.368960 | 0.433 |
R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.368960 | 0.433 |
R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.373970 | 0.427 |
R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.373970 | 0.427 |
R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 0.379099 | 0.421 |
R-HSA-5654719 | SHC-mediated cascade:FGFR4 | 0.379099 | 0.421 |
R-HSA-9694614 | Attachment and Entry | 0.379099 | 0.421 |
R-HSA-5654706 | FRS-mediated FGFR3 signaling | 0.379099 | 0.421 |
R-HSA-9671555 | Signaling by PDGFR in disease | 0.379099 | 0.421 |
R-HSA-175474 | Assembly Of The HIV Virion | 0.379099 | 0.421 |
R-HSA-877300 | Interferon gamma signaling | 0.380150 | 0.420 |
R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.383464 | 0.416 |
R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.383464 | 0.416 |
R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.387694 | 0.412 |
R-HSA-5218859 | Regulated Necrosis | 0.387694 | 0.412 |
R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 0.389972 | 0.409 |
R-HSA-350054 | Notch-HLH transcription pathway | 0.389972 | 0.409 |
R-HSA-5654712 | FRS-mediated FGFR4 signaling | 0.389972 | 0.409 |
R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.389972 | 0.409 |
R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 0.389972 | 0.409 |
R-HSA-9669938 | Signaling by KIT in disease | 0.389972 | 0.409 |
R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.389972 | 0.409 |
R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.389972 | 0.409 |
R-HSA-109581 | Apoptosis | 0.392031 | 0.407 |
R-HSA-1852241 | Organelle biogenesis and maintenance | 0.393106 | 0.405 |
R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.393884 | 0.405 |
R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.397642 | 0.401 |
R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.400047 | 0.398 |
R-HSA-204005 | COPII-mediated vesicle transport | 0.400047 | 0.398 |
R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.400047 | 0.398 |
R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.400047 | 0.398 |
R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 0.400655 | 0.397 |
R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 0.400655 | 0.397 |
R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.400655 | 0.397 |
R-HSA-912526 | Interleukin receptor SHC signaling | 0.400655 | 0.397 |
R-HSA-446210 | Synthesis of UDP-N-acetyl-glucosamine | 0.400655 | 0.397 |
R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.406180 | 0.391 |
R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.406180 | 0.391 |
R-HSA-9007101 | Rab regulation of trafficking | 0.407046 | 0.390 |
R-HSA-70326 | Glucose metabolism | 0.407046 | 0.390 |
R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse | 0.411152 | 0.386 |
R-HSA-5654688 | SHC-mediated cascade:FGFR1 | 0.411152 | 0.386 |
R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.411152 | 0.386 |
R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 0.411152 | 0.386 |
R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 0.411152 | 0.386 |
R-HSA-8963898 | Plasma lipoprotein assembly | 0.411152 | 0.386 |
R-HSA-5693538 | Homology Directed Repair | 0.411732 | 0.385 |
R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.412282 | 0.385 |
R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.416406 | 0.380 |
R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.416406 | 0.380 |
R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.418354 | 0.378 |
R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.418354 | 0.378 |
R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.421466 | 0.375 |
R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.421466 | 0.375 |
R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.421466 | 0.375 |
R-HSA-9839394 | TGFBR3 expression | 0.421466 | 0.375 |
R-HSA-5654693 | FRS-mediated FGFR1 signaling | 0.421466 | 0.375 |
R-HSA-3296469 | Defects in cobalamin (B12) metabolism | 0.421466 | 0.375 |
R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 0.421466 | 0.375 |
R-HSA-1226099 | Signaling by FGFR in disease | 0.424394 | 0.372 |
R-HSA-1474244 | Extracellular matrix organization | 0.424581 | 0.372 |
R-HSA-3371556 | Cellular response to heat stress | 0.425719 | 0.371 |
R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.425719 | 0.371 |
R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.427437 | 0.369 |
R-HSA-72306 | tRNA processing | 0.427437 | 0.369 |
R-HSA-446728 | Cell junction organization | 0.429219 | 0.367 |
R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.430356 | 0.366 |
R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.430356 | 0.366 |
R-HSA-71403 | Citric acid cycle (TCA cycle) | 0.430401 | 0.366 |
R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.431599 | 0.365 |
R-HSA-5689901 | Metalloprotease DUBs | 0.431599 | 0.365 |
R-HSA-525793 | Myogenesis | 0.431599 | 0.365 |
R-HSA-1855183 | Synthesis of IP2, IP, and Ins in the cytosol | 0.431599 | 0.365 |
R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.431599 | 0.365 |
R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.434980 | 0.362 |
R-HSA-1980143 | Signaling by NOTCH1 | 0.436375 | 0.360 |
R-HSA-9020591 | Interleukin-12 signaling | 0.436375 | 0.360 |
R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.439130 | 0.357 |
R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.439130 | 0.357 |
R-HSA-6809371 | Formation of the cornified envelope | 0.439590 | 0.357 |
R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.441556 | 0.355 |
R-HSA-171306 | Packaging Of Telomere Ends | 0.441556 | 0.355 |
R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.441556 | 0.355 |
R-HSA-9759218 | Cobalamin (Cbl) metabolism | 0.441556 | 0.355 |
R-HSA-5654699 | SHC-mediated cascade:FGFR2 | 0.441556 | 0.355 |
R-HSA-73728 | RNA Polymerase I Promoter Opening | 0.441556 | 0.355 |
R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.441556 | 0.355 |
R-HSA-445095 | Interaction between L1 and Ankyrins | 0.441556 | 0.355 |
R-HSA-201451 | Signaling by BMP | 0.441556 | 0.355 |
R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.441556 | 0.355 |
R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.441556 | 0.355 |
R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.441556 | 0.355 |
R-HSA-5655332 | Signaling by FGFR3 in disease | 0.441556 | 0.355 |
R-HSA-9694635 | Translation of Structural Proteins | 0.442315 | 0.354 |
R-HSA-416482 | G alpha (12/13) signalling events | 0.448221 | 0.349 |
R-HSA-167287 | HIV elongation arrest and recovery | 0.451339 | 0.345 |
R-HSA-167290 | Pausing and recovery of HIV elongation | 0.451339 | 0.345 |
R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.451339 | 0.345 |
R-HSA-5576892 | Phase 0 - rapid depolarisation | 0.451339 | 0.345 |
R-HSA-5654700 | FRS-mediated FGFR2 signaling | 0.451339 | 0.345 |
R-HSA-5620971 | Pyroptosis | 0.451339 | 0.345 |
R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.454091 | 0.343 |
R-HSA-69481 | G2/M Checkpoints | 0.457882 | 0.339 |
R-HSA-5654738 | Signaling by FGFR2 | 0.459925 | 0.337 |
R-HSA-6806834 | Signaling by MET | 0.459925 | 0.337 |
R-HSA-5334118 | DNA methylation | 0.460951 | 0.336 |
R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.460951 | 0.336 |
R-HSA-72086 | mRNA Capping | 0.460951 | 0.336 |
R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.460951 | 0.336 |
R-HSA-420092 | Glucagon-type ligand receptors | 0.460951 | 0.336 |
R-HSA-5654708 | Downstream signaling of activated FGFR3 | 0.460951 | 0.336 |
R-HSA-180024 | DARPP-32 events | 0.460951 | 0.336 |
R-HSA-9006335 | Signaling by Erythropoietin | 0.460951 | 0.336 |
R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.465724 | 0.332 |
R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.470395 | 0.328 |
R-HSA-2424491 | DAP12 signaling | 0.470395 | 0.328 |
R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.470395 | 0.328 |
R-HSA-5654716 | Downstream signaling of activated FGFR4 | 0.470395 | 0.328 |
R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 0.470395 | 0.328 |
R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.470395 | 0.328 |
R-HSA-114452 | Activation of BH3-only proteins | 0.470395 | 0.328 |
R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.471434 | 0.327 |
R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.471485 | 0.327 |
R-HSA-9694516 | SARS-CoV-2 Infection | 0.475638 | 0.323 |
R-HSA-1474165 | Reproduction | 0.475918 | 0.322 |
R-HSA-9707564 | Cytoprotection by HMOX1 | 0.477209 | 0.321 |
R-HSA-201681 | TCF dependent signaling in response to WNT | 0.477565 | 0.321 |
R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.479674 | 0.319 |
R-HSA-182971 | EGFR downregulation | 0.479674 | 0.319 |
R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 0.479674 | 0.319 |
R-HSA-186763 | Downstream signal transduction | 0.479674 | 0.319 |
R-HSA-6802957 | Oncogenic MAPK signaling | 0.488543 | 0.311 |
R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.488543 | 0.311 |
R-HSA-4791275 | Signaling by WNT in cancer | 0.488791 | 0.311 |
R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.488791 | 0.311 |
R-HSA-2024096 | HS-GAG degradation | 0.488791 | 0.311 |
R-HSA-1538133 | G0 and Early G1 | 0.488791 | 0.311 |
R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.497750 | 0.303 |
R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.497750 | 0.303 |
R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.497750 | 0.303 |
R-HSA-1839124 | FGFR1 mutant receptor activation | 0.497750 | 0.303 |
R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 0.497750 | 0.303 |
R-HSA-5675482 | Regulation of necroptotic cell death | 0.497750 | 0.303 |
R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.497750 | 0.303 |
R-HSA-447115 | Interleukin-12 family signaling | 0.505254 | 0.296 |
R-HSA-73894 | DNA Repair | 0.506286 | 0.296 |
R-HSA-5693537 | Resolution of D-Loop Structures | 0.506551 | 0.295 |
R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.506551 | 0.295 |
R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.506551 | 0.295 |
R-HSA-163359 | Glucagon signaling in metabolic regulation | 0.506551 | 0.295 |
R-HSA-114508 | Effects of PIP2 hydrolysis | 0.506551 | 0.295 |
R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.506551 | 0.295 |
R-HSA-163685 | Integration of energy metabolism | 0.506795 | 0.295 |
R-HSA-156902 | Peptide chain elongation | 0.510746 | 0.292 |
R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.511130 | 0.291 |
R-HSA-1971475 | Glycosaminoglycan-protein linkage region biosynthesis | 0.515199 | 0.288 |
R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.515199 | 0.288 |
R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.515199 | 0.288 |
R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.515199 | 0.288 |
R-HSA-203615 | eNOS activation | 0.515199 | 0.288 |
R-HSA-1980145 | Signaling by NOTCH2 | 0.515199 | 0.288 |
R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.515199 | 0.288 |
R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 0.515199 | 0.288 |
R-HSA-5205647 | Mitophagy | 0.515199 | 0.288 |
R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.515199 | 0.288 |
R-HSA-72163 | mRNA Splicing - Major Pathway | 0.518629 | 0.285 |
R-HSA-73884 | Base Excision Repair | 0.521608 | 0.283 |
R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.523696 | 0.281 |
R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.523696 | 0.281 |
R-HSA-5654696 | Downstream signaling of activated FGFR2 | 0.523696 | 0.281 |
R-HSA-5654687 | Downstream signaling of activated FGFR1 | 0.523696 | 0.281 |
R-HSA-3296482 | Defects in vitamin and cofactor metabolism | 0.523696 | 0.281 |
R-HSA-187687 | Signalling to ERKs | 0.523696 | 0.281 |
R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.525935 | 0.279 |
R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.526979 | 0.278 |
R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.526979 | 0.278 |
R-HSA-212300 | PRC2 methylates histones and DNA | 0.532045 | 0.274 |
R-HSA-2022928 | HS-GAG biosynthesis | 0.532045 | 0.274 |
R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.532045 | 0.274 |
R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.532045 | 0.274 |
R-HSA-3371511 | HSF1 activation | 0.532045 | 0.274 |
R-HSA-74158 | RNA Polymerase III Transcription | 0.532045 | 0.274 |
R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.532045 | 0.274 |
R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.536707 | 0.270 |
R-HSA-156842 | Eukaryotic Translation Elongation | 0.537597 | 0.270 |
R-HSA-2682334 | EPH-Ephrin signaling | 0.537597 | 0.270 |
R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.537597 | 0.270 |
R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.540247 | 0.267 |
R-HSA-110331 | Cleavage of the damaged purine | 0.540247 | 0.267 |
R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.540247 | 0.267 |
R-HSA-196757 | Metabolism of folate and pterines | 0.540247 | 0.267 |
R-HSA-1500931 | Cell-Cell communication | 0.543927 | 0.264 |
R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.548051 | 0.261 |
R-HSA-6785470 | tRNA processing in the mitochondrion | 0.548307 | 0.261 |
R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.548307 | 0.261 |
R-HSA-73927 | Depurination | 0.548307 | 0.261 |
R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 0.548307 | 0.261 |
R-HSA-8875878 | MET promotes cell motility | 0.548307 | 0.261 |
R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.548307 | 0.261 |
R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.548307 | 0.261 |
R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.551076 | 0.259 |
R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.553216 | 0.257 |
R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.553216 | 0.257 |
R-HSA-71336 | Pentose phosphate pathway | 0.556225 | 0.255 |
R-HSA-3781860 | Diseases associated with N-glycosylation of proteins | 0.556225 | 0.255 |
R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 0.556225 | 0.255 |
R-HSA-72172 | mRNA Splicing | 0.558131 | 0.253 |
R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.558339 | 0.253 |
R-HSA-72764 | Eukaryotic Translation Termination | 0.558339 | 0.253 |
R-HSA-72689 | Formation of a pool of free 40S subunits | 0.558339 | 0.253 |
R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 0.563420 | 0.249 |
R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.563420 | 0.249 |
R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.563420 | 0.249 |
R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.564006 | 0.249 |
R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.564006 | 0.249 |
R-HSA-9854311 | Maturation of TCA enzymes and regulation of TCA cycle | 0.564006 | 0.249 |
R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.564006 | 0.249 |
R-HSA-3371568 | Attenuation phase | 0.564006 | 0.249 |
R-HSA-202433 | Generation of second messenger molecules | 0.564006 | 0.249 |
R-HSA-8868766 | rRNA processing in the mitochondrion | 0.564006 | 0.249 |
R-HSA-379726 | Mitochondrial tRNA aminoacylation | 0.564006 | 0.249 |
R-HSA-112315 | Transmission across Chemical Synapses | 0.564009 | 0.249 |
R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 0.571650 | 0.243 |
R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.571650 | 0.243 |
R-HSA-8957275 | Post-translational protein phosphorylation | 0.573456 | 0.241 |
R-HSA-190236 | Signaling by FGFR | 0.573456 | 0.241 |
R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.577594 | 0.238 |
R-HSA-3214847 | HATs acetylate histones | 0.578412 | 0.238 |
R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.578412 | 0.238 |
R-HSA-9614085 | FOXO-mediated transcription | 0.578412 | 0.238 |
R-HSA-9932298 | Degradation of CRY and PER proteins | 0.579161 | 0.237 |
R-HSA-9609507 | Protein localization | 0.581557 | 0.235 |
R-HSA-5610787 | Hedgehog 'off' state | 0.583325 | 0.234 |
R-HSA-73887 | Death Receptor Signaling | 0.585497 | 0.232 |
R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 0.586540 | 0.232 |
R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.586540 | 0.232 |
R-HSA-2408557 | Selenocysteine synthesis | 0.588196 | 0.230 |
R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.588196 | 0.230 |
R-HSA-449147 | Signaling by Interleukins | 0.589398 | 0.230 |
R-HSA-1989781 | PPARA activates gene expression | 0.589413 | 0.230 |
R-HSA-9842860 | Regulation of endogenous retroelements | 0.593024 | 0.227 |
R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.593024 | 0.227 |
R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.593024 | 0.227 |
R-HSA-9710421 | Defective pyroptosis | 0.593791 | 0.226 |
R-HSA-1433557 | Signaling by SCF-KIT | 0.593791 | 0.226 |
R-HSA-8854214 | TBC/RABGAPs | 0.593791 | 0.226 |
R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.597173 | 0.224 |
R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 0.597173 | 0.224 |
R-HSA-192823 | Viral mRNA Translation | 0.597811 | 0.223 |
R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.600915 | 0.221 |
R-HSA-2172127 | DAP12 interactions | 0.600915 | 0.221 |
R-HSA-196741 | Cobalamin (Cbl, vitamin B12) transport and metabolism | 0.600915 | 0.221 |
R-HSA-3928662 | EPHB-mediated forward signaling | 0.600915 | 0.221 |
R-HSA-3214858 | RMTs methylate histone arginines | 0.600915 | 0.221 |
R-HSA-5683826 | Surfactant metabolism | 0.600915 | 0.221 |
R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.601018 | 0.221 |
R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.602555 | 0.220 |
R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.602555 | 0.220 |
R-HSA-418990 | Adherens junctions interactions | 0.605783 | 0.218 |
R-HSA-9833110 | RSV-host interactions | 0.607257 | 0.217 |
R-HSA-3560782 | Diseases associated with glycosaminoglycan metabolism | 0.607914 | 0.216 |
R-HSA-1280218 | Adaptive Immune System | 0.611313 | 0.214 |
R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.614791 | 0.211 |
R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.614791 | 0.211 |
R-HSA-9675135 | Diseases of DNA repair | 0.614791 | 0.211 |
R-HSA-9839373 | Signaling by TGFBR3 | 0.614791 | 0.211 |
R-HSA-5357905 | Regulation of TNFR1 signaling | 0.614791 | 0.211 |
R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.621109 | 0.207 |
R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.621548 | 0.207 |
R-HSA-2408522 | Selenoamino acid metabolism | 0.623575 | 0.205 |
R-HSA-425410 | Metal ion SLC transporters | 0.628187 | 0.202 |
R-HSA-9031628 | NGF-stimulated transcription | 0.628187 | 0.202 |
R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.634709 | 0.197 |
R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.634709 | 0.197 |
R-HSA-6803157 | Antimicrobial peptides | 0.638991 | 0.195 |
R-HSA-5658442 | Regulation of RAS by GAPs | 0.641118 | 0.193 |
R-HSA-5655253 | Signaling by FGFR2 in disease | 0.641118 | 0.193 |
R-HSA-9824446 | Viral Infection Pathways | 0.646019 | 0.190 |
R-HSA-3371571 | HSF1-dependent transactivation | 0.647415 | 0.189 |
R-HSA-9864848 | Complex IV assembly | 0.647415 | 0.189 |
R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.647681 | 0.189 |
R-HSA-1257604 | PIP3 activates AKT signaling | 0.653422 | 0.185 |
R-HSA-1483257 | Phospholipid metabolism | 0.653422 | 0.185 |
R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.653601 | 0.185 |
R-HSA-72187 | mRNA 3'-end processing | 0.653601 | 0.185 |
R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.653601 | 0.185 |
R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.653601 | 0.185 |
R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.656205 | 0.183 |
R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.659679 | 0.181 |
R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.659679 | 0.181 |
R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.659679 | 0.181 |
R-HSA-445355 | Smooth Muscle Contraction | 0.659679 | 0.181 |
R-HSA-202733 | Cell surface interactions at the vascular wall | 0.665228 | 0.177 |
R-HSA-109582 | Hemostasis | 0.666095 | 0.176 |
R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.671519 | 0.173 |
R-HSA-3214815 | HDACs deacetylate histones | 0.671519 | 0.173 |
R-HSA-9012852 | Signaling by NOTCH3 | 0.671519 | 0.173 |
R-HSA-2980736 | Peptide hormone metabolism | 0.672758 | 0.172 |
R-HSA-1592230 | Mitochondrial biogenesis | 0.672758 | 0.172 |
R-HSA-611105 | Respiratory electron transport | 0.676085 | 0.170 |
R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.677284 | 0.169 |
R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.677284 | 0.169 |
R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.677284 | 0.169 |
R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.677284 | 0.169 |
R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 0.677284 | 0.169 |
R-HSA-75893 | TNF signaling | 0.677284 | 0.169 |
R-HSA-72766 | Translation | 0.682207 | 0.166 |
R-HSA-112399 | IRS-mediated signalling | 0.682948 | 0.166 |
R-HSA-6782135 | Dual incision in TC-NER | 0.688513 | 0.162 |
R-HSA-73886 | Chromosome Maintenance | 0.688661 | 0.162 |
R-HSA-9679506 | SARS-CoV Infections | 0.689046 | 0.162 |
R-HSA-1638091 | Heparan sulfate/heparin (HS-GAG) metabolism | 0.693981 | 0.159 |
R-HSA-9033241 | Peroxisomal protein import | 0.693981 | 0.159 |
R-HSA-4085001 | Sialic acid metabolism | 0.693981 | 0.159 |
R-HSA-352230 | Amino acid transport across the plasma membrane | 0.693981 | 0.159 |
R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.699353 | 0.155 |
R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.699353 | 0.155 |
R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.699353 | 0.155 |
R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.699353 | 0.155 |
R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.699353 | 0.155 |
R-HSA-8873719 | RAB geranylgeranylation | 0.699353 | 0.155 |
R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.699353 | 0.155 |
R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.699353 | 0.155 |
R-HSA-162909 | Host Interactions of HIV factors | 0.700169 | 0.155 |
R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.704631 | 0.152 |
R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.704631 | 0.152 |
R-HSA-9793380 | Formation of paraxial mesoderm | 0.704631 | 0.152 |
R-HSA-421270 | Cell-cell junction organization | 0.704954 | 0.152 |
R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.709817 | 0.149 |
R-HSA-375165 | NCAM signaling for neurite out-growth | 0.709817 | 0.149 |
R-HSA-186797 | Signaling by PDGF | 0.709817 | 0.149 |
R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.709817 | 0.149 |
R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.714912 | 0.146 |
R-HSA-168256 | Immune System | 0.718274 | 0.144 |
R-HSA-74751 | Insulin receptor signalling cascade | 0.719918 | 0.143 |
R-HSA-2428924 | IGF1R signaling cascade | 0.719918 | 0.143 |
R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.724836 | 0.140 |
R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.729669 | 0.137 |
R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 0.729669 | 0.137 |
R-HSA-9843745 | Adipogenesis | 0.732591 | 0.135 |
R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 0.732591 | 0.135 |
R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.734416 | 0.134 |
R-HSA-9958863 | SLC-mediated transport of amino acids | 0.734416 | 0.134 |
R-HSA-416476 | G alpha (q) signalling events | 0.738699 | 0.132 |
R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.739081 | 0.131 |
R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.748166 | 0.126 |
R-HSA-453276 | Regulation of mitotic cell cycle | 0.752590 | 0.123 |
R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.752590 | 0.123 |
R-HSA-3000178 | ECM proteoglycans | 0.752590 | 0.123 |
R-HSA-975634 | Retinoid metabolism and transport | 0.752590 | 0.123 |
R-HSA-8978934 | Metabolism of cofactors | 0.752590 | 0.123 |
R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.752590 | 0.123 |
R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.756937 | 0.121 |
R-HSA-9948299 | Ribosome-associated quality control | 0.758869 | 0.120 |
R-HSA-5358351 | Signaling by Hedgehog | 0.758869 | 0.120 |
R-HSA-112316 | Neuronal System | 0.760974 | 0.119 |
R-HSA-6805567 | Keratinization | 0.761883 | 0.118 |
R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.764198 | 0.117 |
R-HSA-9013694 | Signaling by NOTCH4 | 0.765403 | 0.116 |
R-HSA-425397 | Transport of vitamins, nucleosides, and related molecules | 0.765403 | 0.116 |
R-HSA-1222556 | ROS and RNS production in phagocytes | 0.765403 | 0.116 |
R-HSA-9006925 | Intracellular signaling by second messengers | 0.766276 | 0.116 |
R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.769525 | 0.114 |
R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.769525 | 0.114 |
R-HSA-8852135 | Protein ubiquitination | 0.769525 | 0.114 |
R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.779606 | 0.108 |
R-HSA-216083 | Integrin cell surface interactions | 0.781463 | 0.107 |
R-HSA-9659379 | Sensory processing of sound | 0.785304 | 0.105 |
R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.789078 | 0.103 |
R-HSA-6806667 | Metabolism of fat-soluble vitamins | 0.792785 | 0.101 |
R-HSA-977225 | Amyloid fiber formation | 0.792785 | 0.101 |
R-HSA-9679191 | Potential therapeutics for SARS | 0.796819 | 0.099 |
R-HSA-9856651 | MITF-M-dependent gene expression | 0.796819 | 0.099 |
R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.802165 | 0.096 |
R-HSA-446652 | Interleukin-1 family signaling | 0.802165 | 0.096 |
R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.803523 | 0.095 |
R-HSA-6794362 | Protein-protein interactions at synapses | 0.806977 | 0.093 |
R-HSA-195721 | Signaling by WNT | 0.813082 | 0.090 |
R-HSA-9705683 | SARS-CoV-2-host interactions | 0.813942 | 0.089 |
R-HSA-70268 | Pyruvate metabolism | 0.816981 | 0.088 |
R-HSA-9711097 | Cellular response to starvation | 0.817465 | 0.088 |
R-HSA-9645723 | Diseases of programmed cell death | 0.820200 | 0.086 |
R-HSA-373080 | Class B/2 (Secretin family receptors) | 0.826469 | 0.083 |
R-HSA-74752 | Signaling by Insulin receptor | 0.835466 | 0.078 |
R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.835466 | 0.078 |
R-HSA-157118 | Signaling by NOTCH | 0.838060 | 0.077 |
R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.838361 | 0.077 |
R-HSA-68867 | Assembly of the pre-replicative complex | 0.838361 | 0.077 |
R-HSA-5619102 | SLC transporter disorders | 0.838437 | 0.077 |
R-HSA-9837999 | Mitochondrial protein degradation | 0.841205 | 0.075 |
R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.841537 | 0.075 |
R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.846308 | 0.072 |
R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.849126 | 0.071 |
R-HSA-157579 | Telomere Maintenance | 0.852090 | 0.070 |
R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.852090 | 0.070 |
R-HSA-5689880 | Ub-specific processing proteases | 0.853219 | 0.069 |
R-HSA-422356 | Regulation of insulin secretion | 0.854694 | 0.068 |
R-HSA-9678108 | SARS-CoV-1 Infection | 0.857211 | 0.067 |
R-HSA-5688426 | Deubiquitination | 0.864386 | 0.063 |
R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.866000 | 0.062 |
R-HSA-111885 | Opioid Signalling | 0.869381 | 0.061 |
R-HSA-5696398 | Nucleotide Excision Repair | 0.873940 | 0.059 |
R-HSA-3781865 | Diseases of glycosylation | 0.873977 | 0.059 |
R-HSA-418346 | Platelet homeostasis | 0.876160 | 0.057 |
R-HSA-9692914 | SARS-CoV-1-host interactions | 0.876160 | 0.057 |
R-HSA-1236975 | Antigen processing-Cross presentation | 0.880484 | 0.055 |
R-HSA-2672351 | Stimuli-sensing channels | 0.880484 | 0.055 |
R-HSA-69002 | DNA Replication Pre-Initiation | 0.882588 | 0.054 |
R-HSA-202403 | TCR signaling | 0.884657 | 0.053 |
R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.887342 | 0.052 |
R-HSA-2871796 | FCERI mediated MAPK activation | 0.888684 | 0.051 |
R-HSA-1630316 | Glycosaminoglycan metabolism | 0.888917 | 0.051 |
R-HSA-76002 | Platelet activation, signaling and aggregation | 0.892295 | 0.049 |
R-HSA-166663 | Initial triggering of complement | 0.894465 | 0.048 |
R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.896324 | 0.048 |
R-HSA-428157 | Sphingolipid metabolism | 0.900805 | 0.045 |
R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.902426 | 0.045 |
R-HSA-196854 | Metabolism of vitamins and cofactors | 0.908247 | 0.042 |
R-HSA-977606 | Regulation of Complement cascade | 0.914745 | 0.039 |
R-HSA-168249 | Innate Immune System | 0.916299 | 0.038 |
R-HSA-397014 | Muscle contraction | 0.916436 | 0.038 |
R-HSA-114608 | Platelet degranulation | 0.919176 | 0.037 |
R-HSA-392499 | Metabolism of proteins | 0.920078 | 0.036 |
R-HSA-6798695 | Neutrophil degranulation | 0.925519 | 0.034 |
R-HSA-5576891 | Cardiac conduction | 0.926057 | 0.033 |
R-HSA-8951664 | Neddylation | 0.926612 | 0.033 |
R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.928643 | 0.032 |
R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.935613 | 0.029 |
R-HSA-425407 | SLC-mediated transmembrane transport | 0.938067 | 0.028 |
R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.939210 | 0.027 |
R-HSA-166658 | Complement cascade | 0.944390 | 0.025 |
R-HSA-2187338 | Visual phototransduction | 0.946337 | 0.024 |
R-HSA-597592 | Post-translational protein modification | 0.947739 | 0.023 |
R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.949130 | 0.023 |
R-HSA-5619115 | Disorders of transmembrane transporters | 0.949842 | 0.022 |
R-HSA-69306 | DNA Replication | 0.951779 | 0.021 |
R-HSA-1643685 | Disease | 0.957149 | 0.019 |
R-HSA-9734767 | Developmental Cell Lineages | 0.960459 | 0.018 |
R-HSA-418555 | G alpha (s) signalling events | 0.965640 | 0.015 |
R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.966248 | 0.015 |
R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.967431 | 0.014 |
R-HSA-983712 | Ion channel transport | 0.975085 | 0.011 |
R-HSA-389948 | Co-inhibition by PD-1 | 0.979532 | 0.009 |
R-HSA-8957322 | Metabolism of steroids | 0.984372 | 0.007 |
R-HSA-5668914 | Diseases of metabolism | 0.986082 | 0.006 |
R-HSA-388396 | GPCR downstream signalling | 0.987616 | 0.005 |
R-HSA-5663205 | Infectious disease | 0.991317 | 0.004 |
R-HSA-372790 | Signaling by GPCR | 0.995296 | 0.002 |
R-HSA-418594 | G alpha (i) signalling events | 0.995835 | 0.002 |
R-HSA-71291 | Metabolism of amino acids and derivatives | 0.999175 | 0.000 |
R-HSA-9824439 | Bacterial Infection Pathways | 0.999353 | 0.000 |
R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.999398 | 0.000 |
R-HSA-382551 | Transport of small molecules | 0.999695 | 0.000 |
R-HSA-500792 | GPCR ligand binding | 0.999790 | 0.000 |
R-HSA-556833 | Metabolism of lipids | 0.999877 | 0.000 |
R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
R-HSA-9709957 | Sensory Perception | 1.000000 | 0.000 |
Download
kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
---|---|---|---|---|
CLK3 |
0.890 | 0.449 | 1 | 0.907 |
KIS |
0.883 | 0.478 | 1 | 0.879 |
COT |
0.877 | 0.091 | 2 | 0.883 |
NLK |
0.877 | 0.449 | 1 | 0.910 |
HIPK4 |
0.875 | 0.349 | 1 | 0.873 |
CDK18 |
0.872 | 0.518 | 1 | 0.836 |
SRPK1 |
0.871 | 0.258 | -3 | 0.737 |
CDK8 |
0.871 | 0.456 | 1 | 0.870 |
DYRK2 |
0.870 | 0.469 | 1 | 0.878 |
CDK19 |
0.869 | 0.463 | 1 | 0.847 |
ERK5 |
0.869 | 0.272 | 1 | 0.851 |
MOS |
0.869 | 0.117 | 1 | 0.827 |
HIPK2 |
0.869 | 0.493 | 1 | 0.834 |
CDC7 |
0.869 | 0.024 | 1 | 0.796 |
MTOR |
0.868 | 0.124 | 1 | 0.793 |
JNK2 |
0.868 | 0.533 | 1 | 0.847 |
CDK7 |
0.867 | 0.450 | 1 | 0.879 |
PIM3 |
0.867 | 0.076 | -3 | 0.824 |
NDR2 |
0.866 | 0.075 | -3 | 0.834 |
RSK2 |
0.866 | 0.143 | -3 | 0.769 |
PRKD1 |
0.865 | 0.139 | -3 | 0.818 |
CDKL1 |
0.865 | 0.136 | -3 | 0.777 |
CDK5 |
0.865 | 0.470 | 1 | 0.883 |
CDKL5 |
0.865 | 0.159 | -3 | 0.772 |
PRPK |
0.864 | -0.080 | -1 | 0.848 |
ICK |
0.864 | 0.265 | -3 | 0.819 |
HIPK1 |
0.864 | 0.465 | 1 | 0.886 |
CDK1 |
0.864 | 0.461 | 1 | 0.862 |
PRKD2 |
0.864 | 0.153 | -3 | 0.772 |
CDK13 |
0.864 | 0.451 | 1 | 0.863 |
CDK17 |
0.863 | 0.495 | 1 | 0.805 |
CLK2 |
0.863 | 0.371 | -3 | 0.749 |
CAMK1B |
0.863 | 0.074 | -3 | 0.845 |
CLK4 |
0.863 | 0.324 | -3 | 0.760 |
P38G |
0.863 | 0.507 | 1 | 0.801 |
CLK1 |
0.862 | 0.340 | -3 | 0.746 |
JNK3 |
0.862 | 0.498 | 1 | 0.870 |
SRPK2 |
0.862 | 0.203 | -3 | 0.658 |
SKMLCK |
0.861 | 0.139 | -2 | 0.912 |
P38A |
0.861 | 0.480 | 1 | 0.878 |
P38B |
0.860 | 0.492 | 1 | 0.847 |
AURC |
0.860 | 0.192 | -2 | 0.766 |
P90RSK |
0.859 | 0.088 | -3 | 0.771 |
ERK1 |
0.859 | 0.470 | 1 | 0.841 |
RAF1 |
0.859 | -0.110 | 1 | 0.762 |
PKN3 |
0.858 | 0.052 | -3 | 0.808 |
RSK3 |
0.858 | 0.094 | -3 | 0.760 |
CDK12 |
0.858 | 0.456 | 1 | 0.847 |
NDR1 |
0.858 | 0.057 | -3 | 0.826 |
CAMLCK |
0.858 | 0.117 | -2 | 0.899 |
GCN2 |
0.857 | -0.165 | 2 | 0.855 |
CDK14 |
0.857 | 0.496 | 1 | 0.861 |
CDK3 |
0.857 | 0.435 | 1 | 0.820 |
ATR |
0.857 | -0.026 | 1 | 0.758 |
DYRK1A |
0.857 | 0.383 | 1 | 0.892 |
PIM1 |
0.857 | 0.111 | -3 | 0.765 |
TBK1 |
0.857 | -0.109 | 1 | 0.662 |
PKACG |
0.857 | 0.136 | -2 | 0.837 |
DSTYK |
0.856 | -0.072 | 2 | 0.903 |
PKCD |
0.856 | 0.122 | 2 | 0.843 |
DAPK2 |
0.856 | 0.106 | -3 | 0.852 |
PDHK4 |
0.856 | -0.241 | 1 | 0.798 |
CDK16 |
0.856 | 0.495 | 1 | 0.816 |
WNK1 |
0.856 | 0.042 | -2 | 0.901 |
DYRK4 |
0.855 | 0.462 | 1 | 0.850 |
NIK |
0.855 | 0.047 | -3 | 0.863 |
BMPR2 |
0.855 | -0.166 | -2 | 0.879 |
MST4 |
0.855 | 0.074 | 2 | 0.874 |
CDK9 |
0.855 | 0.426 | 1 | 0.865 |
IKKB |
0.854 | -0.156 | -2 | 0.763 |
P70S6KB |
0.854 | 0.093 | -3 | 0.784 |
ULK2 |
0.854 | -0.173 | 2 | 0.846 |
HIPK3 |
0.854 | 0.422 | 1 | 0.862 |
PKN2 |
0.853 | 0.068 | -3 | 0.817 |
CAMK2G |
0.853 | -0.091 | 2 | 0.828 |
DYRK1B |
0.853 | 0.442 | 1 | 0.860 |
CDK10 |
0.853 | 0.473 | 1 | 0.854 |
CHAK2 |
0.853 | -0.005 | -1 | 0.837 |
NEK6 |
0.853 | -0.065 | -2 | 0.856 |
P38D |
0.852 | 0.498 | 1 | 0.803 |
SRPK3 |
0.852 | 0.160 | -3 | 0.696 |
RSK4 |
0.852 | 0.136 | -3 | 0.739 |
IKKE |
0.852 | -0.141 | 1 | 0.658 |
TGFBR2 |
0.851 | -0.040 | -2 | 0.803 |
ERK2 |
0.851 | 0.433 | 1 | 0.866 |
NUAK2 |
0.851 | 0.024 | -3 | 0.829 |
RIPK3 |
0.851 | -0.065 | 3 | 0.728 |
PKACB |
0.851 | 0.182 | -2 | 0.780 |
MNK2 |
0.850 | 0.134 | -2 | 0.860 |
DYRK3 |
0.850 | 0.384 | 1 | 0.872 |
PDHK1 |
0.850 | -0.231 | 1 | 0.771 |
LATS2 |
0.850 | 0.001 | -5 | 0.746 |
MARK4 |
0.850 | -0.008 | 4 | 0.830 |
MAPKAPK3 |
0.850 | 0.009 | -3 | 0.771 |
AMPKA1 |
0.849 | 0.028 | -3 | 0.841 |
GRK1 |
0.849 | 0.022 | -2 | 0.804 |
PAK1 |
0.849 | 0.096 | -2 | 0.846 |
PRKD3 |
0.848 | 0.095 | -3 | 0.741 |
GRK5 |
0.848 | -0.155 | -3 | 0.815 |
AURB |
0.848 | 0.149 | -2 | 0.759 |
PRKX |
0.847 | 0.196 | -3 | 0.686 |
CDK2 |
0.847 | 0.304 | 1 | 0.888 |
PRP4 |
0.847 | 0.312 | -3 | 0.776 |
LATS1 |
0.847 | 0.103 | -3 | 0.861 |
BMPR1B |
0.847 | 0.115 | 1 | 0.757 |
TSSK2 |
0.847 | 0.047 | -5 | 0.844 |
TSSK1 |
0.847 | 0.076 | -3 | 0.866 |
MAPKAPK2 |
0.846 | 0.027 | -3 | 0.725 |
PAK3 |
0.846 | 0.063 | -2 | 0.838 |
PKG2 |
0.846 | 0.160 | -2 | 0.789 |
CAMK2D |
0.846 | -0.046 | -3 | 0.825 |
SGK3 |
0.846 | 0.154 | -3 | 0.751 |
PAK6 |
0.846 | 0.154 | -2 | 0.776 |
NEK7 |
0.846 | -0.203 | -3 | 0.806 |
MNK1 |
0.845 | 0.127 | -2 | 0.871 |
ALK4 |
0.845 | 0.050 | -2 | 0.844 |
IKKA |
0.845 | -0.069 | -2 | 0.751 |
MLK1 |
0.844 | -0.150 | 2 | 0.865 |
PKCA |
0.844 | 0.097 | 2 | 0.795 |
NIM1 |
0.844 | -0.007 | 3 | 0.742 |
GRK6 |
0.844 | -0.067 | 1 | 0.778 |
TGFBR1 |
0.844 | 0.070 | -2 | 0.813 |
PKCG |
0.843 | 0.063 | 2 | 0.802 |
PKCB |
0.843 | 0.070 | 2 | 0.798 |
AMPKA2 |
0.843 | 0.024 | -3 | 0.812 |
ULK1 |
0.843 | -0.213 | -3 | 0.780 |
AKT2 |
0.843 | 0.122 | -3 | 0.682 |
CAMK4 |
0.843 | -0.006 | -3 | 0.807 |
MSK2 |
0.843 | 0.026 | -3 | 0.720 |
WNK3 |
0.842 | -0.201 | 1 | 0.726 |
MSK1 |
0.842 | 0.091 | -3 | 0.727 |
BCKDK |
0.842 | -0.190 | -1 | 0.798 |
MASTL |
0.841 | -0.250 | -2 | 0.809 |
HUNK |
0.841 | -0.194 | 2 | 0.840 |
NEK9 |
0.841 | -0.164 | 2 | 0.882 |
MAK |
0.841 | 0.372 | -2 | 0.791 |
IRE1 |
0.841 | -0.064 | 1 | 0.706 |
MLK2 |
0.841 | -0.115 | 2 | 0.871 |
GRK7 |
0.840 | 0.066 | 1 | 0.733 |
MELK |
0.840 | 0.009 | -3 | 0.802 |
MLK3 |
0.840 | -0.034 | 2 | 0.807 |
PKR |
0.839 | -0.002 | 1 | 0.759 |
ANKRD3 |
0.839 | -0.169 | 1 | 0.768 |
PKCZ |
0.839 | 0.032 | 2 | 0.840 |
CAMK2B |
0.839 | -0.003 | 2 | 0.778 |
MYLK4 |
0.839 | 0.074 | -2 | 0.844 |
PIM2 |
0.839 | 0.095 | -3 | 0.736 |
AURA |
0.838 | 0.113 | -2 | 0.725 |
RIPK1 |
0.838 | -0.184 | 1 | 0.724 |
CAMK2A |
0.838 | 0.008 | 2 | 0.797 |
PAK2 |
0.838 | 0.039 | -2 | 0.830 |
IRE2 |
0.837 | -0.031 | 2 | 0.832 |
PKCH |
0.837 | 0.033 | 2 | 0.797 |
JNK1 |
0.837 | 0.417 | 1 | 0.845 |
CDK6 |
0.837 | 0.431 | 1 | 0.844 |
FAM20C |
0.837 | 0.022 | 2 | 0.607 |
DLK |
0.837 | -0.247 | 1 | 0.760 |
CDK4 |
0.837 | 0.445 | 1 | 0.840 |
PKACA |
0.837 | 0.154 | -2 | 0.742 |
ATM |
0.837 | -0.071 | 1 | 0.692 |
PHKG1 |
0.837 | -0.024 | -3 | 0.818 |
QSK |
0.837 | 0.008 | 4 | 0.802 |
VRK2 |
0.836 | -0.045 | 1 | 0.819 |
PLK1 |
0.836 | -0.094 | -2 | 0.794 |
NEK2 |
0.835 | -0.062 | 2 | 0.870 |
QIK |
0.835 | -0.063 | -3 | 0.818 |
NUAK1 |
0.835 | -0.034 | -3 | 0.786 |
TTBK2 |
0.835 | -0.206 | 2 | 0.761 |
GRK4 |
0.835 | -0.190 | -2 | 0.828 |
ALK2 |
0.834 | 0.031 | -2 | 0.819 |
SIK |
0.833 | -0.005 | -3 | 0.751 |
DCAMKL1 |
0.833 | 0.051 | -3 | 0.790 |
AKT1 |
0.833 | 0.129 | -3 | 0.704 |
ACVR2B |
0.833 | -0.002 | -2 | 0.802 |
MEK1 |
0.832 | -0.169 | 2 | 0.871 |
ACVR2A |
0.832 | -0.022 | -2 | 0.787 |
MOK |
0.832 | 0.329 | 1 | 0.852 |
DNAPK |
0.832 | -0.011 | 1 | 0.636 |
CHK1 |
0.831 | -0.018 | -3 | 0.823 |
YSK4 |
0.831 | -0.149 | 1 | 0.696 |
SMG1 |
0.830 | -0.080 | 1 | 0.704 |
ERK7 |
0.830 | 0.190 | 2 | 0.603 |
BRSK1 |
0.829 | -0.054 | -3 | 0.785 |
MLK4 |
0.829 | -0.107 | 2 | 0.790 |
TLK2 |
0.829 | -0.095 | 1 | 0.707 |
CHAK1 |
0.829 | -0.157 | 2 | 0.845 |
MPSK1 |
0.829 | 0.106 | 1 | 0.737 |
BMPR1A |
0.828 | 0.068 | 1 | 0.736 |
SMMLCK |
0.828 | 0.056 | -3 | 0.797 |
MARK3 |
0.828 | -0.021 | 4 | 0.754 |
GSK3A |
0.827 | 0.125 | 4 | 0.458 |
CAMK1G |
0.827 | -0.022 | -3 | 0.745 |
PINK1 |
0.827 | -0.040 | 1 | 0.836 |
PKCT |
0.827 | 0.039 | 2 | 0.802 |
DRAK1 |
0.827 | -0.082 | 1 | 0.717 |
GRK2 |
0.826 | -0.060 | -2 | 0.746 |
BRSK2 |
0.826 | -0.092 | -3 | 0.811 |
MST3 |
0.826 | 0.037 | 2 | 0.876 |
PLK4 |
0.826 | -0.091 | 2 | 0.709 |
DCAMKL2 |
0.826 | 0.010 | -3 | 0.816 |
MARK2 |
0.826 | -0.049 | 4 | 0.717 |
BRAF |
0.825 | -0.102 | -4 | 0.853 |
P70S6K |
0.825 | 0.023 | -3 | 0.689 |
PERK |
0.825 | -0.144 | -2 | 0.825 |
NEK5 |
0.824 | -0.079 | 1 | 0.732 |
WNK4 |
0.824 | -0.081 | -2 | 0.883 |
SNRK |
0.824 | -0.165 | 2 | 0.769 |
PLK3 |
0.823 | -0.139 | 2 | 0.791 |
PKCI |
0.823 | 0.042 | 2 | 0.810 |
MEK5 |
0.823 | -0.219 | 2 | 0.872 |
SGK1 |
0.823 | 0.128 | -3 | 0.599 |
IRAK4 |
0.822 | -0.085 | 1 | 0.699 |
DAPK3 |
0.822 | 0.100 | -3 | 0.793 |
PAK5 |
0.822 | 0.078 | -2 | 0.718 |
PKCE |
0.822 | 0.090 | 2 | 0.793 |
SSTK |
0.822 | 0.014 | 4 | 0.790 |
TAO3 |
0.822 | -0.006 | 1 | 0.731 |
MEKK2 |
0.822 | -0.109 | 2 | 0.859 |
PHKG2 |
0.821 | -0.018 | -3 | 0.796 |
AKT3 |
0.821 | 0.116 | -3 | 0.619 |
MAPKAPK5 |
0.821 | -0.140 | -3 | 0.691 |
HRI |
0.821 | -0.207 | -2 | 0.843 |
CK1E |
0.821 | -0.048 | -3 | 0.494 |
MEKK1 |
0.821 | -0.172 | 1 | 0.722 |
PASK |
0.821 | -0.020 | -3 | 0.832 |
ZAK |
0.821 | -0.167 | 1 | 0.702 |
CAMK1D |
0.820 | 0.026 | -3 | 0.691 |
GSK3B |
0.820 | 0.015 | 4 | 0.448 |
MARK1 |
0.820 | -0.081 | 4 | 0.778 |
PAK4 |
0.819 | 0.084 | -2 | 0.724 |
MEKK3 |
0.818 | -0.213 | 1 | 0.725 |
TLK1 |
0.818 | -0.148 | -2 | 0.829 |
MRCKB |
0.817 | 0.121 | -3 | 0.729 |
ROCK2 |
0.817 | 0.146 | -3 | 0.782 |
MRCKA |
0.816 | 0.115 | -3 | 0.749 |
LKB1 |
0.816 | -0.032 | -3 | 0.817 |
DAPK1 |
0.816 | 0.082 | -3 | 0.767 |
PKN1 |
0.816 | 0.034 | -3 | 0.716 |
GAK |
0.816 | 0.001 | 1 | 0.785 |
BUB1 |
0.816 | 0.165 | -5 | 0.811 |
TAO2 |
0.815 | -0.044 | 2 | 0.892 |
GCK |
0.813 | -0.006 | 1 | 0.732 |
PDK1 |
0.813 | -0.062 | 1 | 0.738 |
NEK11 |
0.813 | -0.158 | 1 | 0.728 |
TNIK |
0.813 | 0.031 | 3 | 0.832 |
CK2A2 |
0.812 | 0.044 | 1 | 0.691 |
NEK8 |
0.812 | -0.175 | 2 | 0.878 |
CHK2 |
0.812 | 0.020 | -3 | 0.634 |
SBK |
0.811 | 0.091 | -3 | 0.569 |
CAMKK1 |
0.811 | -0.198 | -2 | 0.761 |
NEK4 |
0.811 | -0.105 | 1 | 0.695 |
HGK |
0.810 | -0.027 | 3 | 0.835 |
CK1D |
0.810 | -0.049 | -3 | 0.441 |
EEF2K |
0.810 | -0.039 | 3 | 0.792 |
GRK3 |
0.810 | -0.074 | -2 | 0.708 |
MAP3K15 |
0.810 | -0.061 | 1 | 0.689 |
HPK1 |
0.810 | 0.007 | 1 | 0.719 |
MEKK6 |
0.809 | -0.072 | 1 | 0.706 |
CAMKK2 |
0.809 | -0.155 | -2 | 0.768 |
LOK |
0.809 | -0.010 | -2 | 0.798 |
DMPK1 |
0.809 | 0.157 | -3 | 0.755 |
CK1G1 |
0.809 | -0.097 | -3 | 0.499 |
CAMK1A |
0.808 | 0.035 | -3 | 0.649 |
LRRK2 |
0.808 | -0.082 | 2 | 0.896 |
CK1A2 |
0.807 | -0.060 | -3 | 0.439 |
KHS1 |
0.807 | 0.041 | 1 | 0.704 |
TTBK1 |
0.807 | -0.222 | 2 | 0.679 |
MINK |
0.807 | -0.067 | 1 | 0.706 |
NEK1 |
0.807 | -0.061 | 1 | 0.702 |
KHS2 |
0.807 | 0.068 | 1 | 0.722 |
MST2 |
0.806 | -0.122 | 1 | 0.725 |
PDHK3_TYR |
0.806 | 0.294 | 4 | 0.919 |
PBK |
0.805 | 0.025 | 1 | 0.700 |
PKG1 |
0.804 | 0.082 | -2 | 0.713 |
ROCK1 |
0.803 | 0.120 | -3 | 0.744 |
TAK1 |
0.802 | -0.164 | 1 | 0.740 |
CK2A1 |
0.802 | 0.020 | 1 | 0.671 |
VRK1 |
0.802 | -0.161 | 2 | 0.876 |
SLK |
0.802 | -0.067 | -2 | 0.744 |
IRAK1 |
0.800 | -0.343 | -1 | 0.735 |
CRIK |
0.800 | 0.094 | -3 | 0.696 |
YSK1 |
0.799 | -0.061 | 2 | 0.859 |
MST1 |
0.799 | -0.135 | 1 | 0.705 |
PLK2 |
0.797 | -0.091 | -3 | 0.767 |
TESK1_TYR |
0.796 | 0.046 | 3 | 0.853 |
MEK2 |
0.795 | -0.251 | 2 | 0.857 |
HASPIN |
0.795 | 0.005 | -1 | 0.676 |
LIMK2_TYR |
0.795 | 0.158 | -3 | 0.878 |
STK33 |
0.795 | -0.194 | 2 | 0.672 |
PDHK4_TYR |
0.794 | 0.067 | 2 | 0.899 |
MAP2K4_TYR |
0.793 | 0.029 | -1 | 0.871 |
PKMYT1_TYR |
0.793 | 0.074 | 3 | 0.827 |
NEK3 |
0.793 | -0.134 | 1 | 0.670 |
TTK |
0.792 | -0.047 | -2 | 0.812 |
RIPK2 |
0.791 | -0.303 | 1 | 0.658 |
MAP2K6_TYR |
0.791 | -0.006 | -1 | 0.867 |
MAP2K7_TYR |
0.790 | -0.105 | 2 | 0.899 |
MYO3B |
0.790 | -0.018 | 2 | 0.882 |
OSR1 |
0.788 | -0.113 | 2 | 0.839 |
BIKE |
0.788 | 0.001 | 1 | 0.677 |
PDHK1_TYR |
0.787 | -0.058 | -1 | 0.877 |
BMPR2_TYR |
0.787 | -0.023 | -1 | 0.846 |
PINK1_TYR |
0.785 | -0.159 | 1 | 0.785 |
ASK1 |
0.785 | -0.139 | 1 | 0.683 |
TAO1 |
0.783 | -0.086 | 1 | 0.649 |
MYO3A |
0.783 | -0.078 | 1 | 0.702 |
LIMK1_TYR |
0.782 | -0.084 | 2 | 0.903 |
EPHA6 |
0.782 | -0.020 | -1 | 0.833 |
RET |
0.781 | -0.109 | 1 | 0.725 |
ROS1 |
0.778 | -0.090 | 3 | 0.747 |
EPHB4 |
0.778 | -0.058 | -1 | 0.815 |
MST1R |
0.778 | -0.120 | 3 | 0.789 |
TYRO3 |
0.777 | -0.125 | 3 | 0.773 |
CSF1R |
0.776 | -0.095 | 3 | 0.775 |
TXK |
0.776 | 0.022 | 1 | 0.764 |
YANK3 |
0.776 | -0.103 | 2 | 0.427 |
TYK2 |
0.776 | -0.196 | 1 | 0.716 |
ALPHAK3 |
0.776 | -0.132 | -1 | 0.752 |
AAK1 |
0.776 | 0.054 | 1 | 0.591 |
JAK2 |
0.776 | -0.131 | 1 | 0.720 |
ABL2 |
0.775 | -0.046 | -1 | 0.804 |
DDR1 |
0.775 | -0.143 | 4 | 0.828 |
YES1 |
0.773 | -0.074 | -1 | 0.835 |
TNK2 |
0.773 | -0.051 | 3 | 0.750 |
ABL1 |
0.772 | -0.064 | -1 | 0.799 |
FGR |
0.771 | -0.146 | 1 | 0.759 |
TNNI3K_TYR |
0.771 | -0.009 | 1 | 0.730 |
JAK3 |
0.771 | -0.146 | 1 | 0.713 |
TNK1 |
0.770 | -0.050 | 3 | 0.758 |
INSRR |
0.770 | -0.125 | 3 | 0.719 |
CK1A |
0.770 | -0.094 | -3 | 0.351 |
FGFR2 |
0.769 | -0.116 | 3 | 0.768 |
EPHA4 |
0.768 | -0.092 | 2 | 0.781 |
FER |
0.768 | -0.193 | 1 | 0.784 |
KDR |
0.768 | -0.095 | 3 | 0.740 |
NEK10_TYR |
0.767 | -0.117 | 1 | 0.625 |
JAK1 |
0.766 | -0.066 | 1 | 0.664 |
LCK |
0.766 | -0.064 | -1 | 0.806 |
HCK |
0.766 | -0.135 | -1 | 0.807 |
PDGFRB |
0.766 | -0.192 | 3 | 0.783 |
MERTK |
0.766 | -0.084 | 3 | 0.756 |
BLK |
0.765 | -0.030 | -1 | 0.817 |
SRMS |
0.765 | -0.143 | 1 | 0.766 |
EPHB1 |
0.765 | -0.146 | 1 | 0.754 |
AXL |
0.765 | -0.127 | 3 | 0.759 |
KIT |
0.764 | -0.172 | 3 | 0.775 |
EPHB3 |
0.764 | -0.133 | -1 | 0.799 |
TEK |
0.764 | -0.131 | 3 | 0.710 |
ITK |
0.764 | -0.134 | -1 | 0.775 |
STLK3 |
0.764 | -0.271 | 1 | 0.664 |
FGFR1 |
0.764 | -0.138 | 3 | 0.743 |
EPHB2 |
0.763 | -0.117 | -1 | 0.793 |
FLT3 |
0.761 | -0.206 | 3 | 0.775 |
WEE1_TYR |
0.759 | -0.126 | -1 | 0.726 |
MET |
0.759 | -0.155 | 3 | 0.768 |
DDR2 |
0.759 | -0.029 | 3 | 0.707 |
TEC |
0.759 | -0.125 | -1 | 0.729 |
PDGFRA |
0.759 | -0.247 | 3 | 0.777 |
ALK |
0.759 | -0.167 | 3 | 0.690 |
BMX |
0.758 | -0.115 | -1 | 0.699 |
LTK |
0.758 | -0.162 | 3 | 0.714 |
PTK2B |
0.757 | -0.057 | -1 | 0.769 |
EPHA7 |
0.757 | -0.124 | 2 | 0.796 |
FYN |
0.757 | -0.071 | -1 | 0.777 |
FGFR3 |
0.756 | -0.147 | 3 | 0.740 |
EPHA1 |
0.756 | -0.135 | 3 | 0.752 |
FLT1 |
0.755 | -0.178 | -1 | 0.800 |
FRK |
0.754 | -0.135 | -1 | 0.827 |
BTK |
0.754 | -0.261 | -1 | 0.752 |
NTRK1 |
0.753 | -0.256 | -1 | 0.797 |
EPHA3 |
0.752 | -0.194 | 2 | 0.770 |
ERBB2 |
0.752 | -0.229 | 1 | 0.697 |
FLT4 |
0.751 | -0.223 | 3 | 0.729 |
PTK6 |
0.751 | -0.278 | -1 | 0.706 |
INSR |
0.750 | -0.216 | 3 | 0.698 |
NTRK2 |
0.750 | -0.267 | 3 | 0.731 |
MATK |
0.749 | -0.160 | -1 | 0.731 |
LYN |
0.749 | -0.176 | 3 | 0.697 |
NTRK3 |
0.748 | -0.198 | -1 | 0.750 |
EPHA5 |
0.748 | -0.145 | 2 | 0.773 |
EPHA8 |
0.746 | -0.149 | -1 | 0.774 |
SRC |
0.745 | -0.146 | -1 | 0.785 |
EGFR |
0.745 | -0.136 | 1 | 0.618 |
CK1G3 |
0.744 | -0.118 | -3 | 0.302 |
PTK2 |
0.743 | -0.065 | -1 | 0.743 |
CSK |
0.741 | -0.219 | 2 | 0.803 |
SYK |
0.740 | -0.089 | -1 | 0.736 |
FGFR4 |
0.739 | -0.170 | -1 | 0.748 |
YANK2 |
0.739 | -0.141 | 2 | 0.442 |
MUSK |
0.738 | -0.181 | 1 | 0.600 |
EPHA2 |
0.736 | -0.154 | -1 | 0.738 |
IGF1R |
0.735 | -0.205 | 3 | 0.633 |
ERBB4 |
0.732 | -0.131 | 1 | 0.647 |
CK1G2 |
0.724 | -0.130 | -3 | 0.405 |
FES |
0.721 | -0.203 | -1 | 0.678 |
ZAP70 |
0.719 | -0.105 | -1 | 0.660 |