Motif 832 (n=92)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| B2RUZ4 | SMIM1 | S27 | ochoa | Small integral membrane protein 1 (Vel blood group antigen) | Regulator of red blood cell formation. {ECO:0000250|UniProtKB:B3DHH5}. |
| H3BQZ7 | HNRNPUL2-BSCL2 | S543 | ochoa | Heterogeneous nuclear ribonucleoprotein U-like protein 2 | None |
| O15160 | POLR1C | S34 | ochoa | DNA-directed RNA polymerases I and III subunit RPAC1 (DNA-directed RNA polymerase I subunit C) (RNA polymerases I and III subunit AC1) (AC40) (DNA-directed RNA polymerases I and III 40 kDa polypeptide) (RPA40) (RPA39) (RPC40) | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and short non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs, respectively. POLR1C/RPAC1 is part of the polymerase core and may function as a clamp element that moves to open and close the cleft. {ECO:0000250|UniProtKB:P07703, ECO:0000269|PubMed:20413673, ECO:0000269|PubMed:34671025, ECO:0000269|PubMed:34887565, ECO:0000269|PubMed:36271492, ECO:0000305|PubMed:26151409}. |
| O60563 | CCNT1 | S363 | ochoa | Cyclin-T1 (CycT1) (Cyclin-T) | Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II) (PubMed:16109376, PubMed:16109377, PubMed:30134174, PubMed:35393539). Required to activate the protein kinase activity of CDK9: acts by mediating formation of liquid-liquid phase separation (LLPS) that enhances binding of P-TEFb to the CTD of RNA Pol II (PubMed:29849146, PubMed:35393539). {ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377, ECO:0000269|PubMed:29849146, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:35393539}.; FUNCTION: (Microbial infection) In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes. {ECO:0000269|PubMed:10329125, ECO:0000269|PubMed:10329126}. |
| O60658 | PDE8A | S59 | ochoa | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.53) | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:18983167). May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development (PubMed:18983167). Binding to RAF1 reduces RAF1 'Ser-259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling (PubMed:23509299). Protects against cell death induced by hydrogen peroxide and staurosporine (PubMed:23509299). {ECO:0000269|PubMed:18983167, ECO:0000269|PubMed:23509299}. |
| O75122 | CLASP2 | S596 | ochoa | CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (Protein Orbit homolog 2) (hOrbit2) | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16824950, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:26003921}. |
| O75746 | SLC25A12 | S101 | ochoa | Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial (Araceli hiperlarga) (Aralar) (Aralar1) (Mitochondrial aspartate glutamate carrier 1) (Solute carrier family 25 member 12) | Mitochondrial electrogenic aspartate/glutamate antiporter that favors efflux of aspartate and entry of glutamate and proton within the mitochondria as part of the malate-aspartate shuttle (PubMed:11566871, PubMed:19641205, PubMed:24515575, PubMed:38945283). Also mediates the uptake of L-cysteinesulfinate (3-sulfino-L-alanine) by mitochondria in exchange of L-glutamate and proton (PubMed:11566871). Can also exchange L-cysteinesulfinate with aspartate in their anionic form without any proton translocation (PubMed:11566871). Lacks transport activity towards L-glutamine or gamma-aminobutyric acid (GABA) (PubMed:38945283). {ECO:0000269|PubMed:11566871, ECO:0000269|PubMed:19641205, ECO:0000269|PubMed:24515575, ECO:0000269|PubMed:38945283}. |
| O94905 | ERLIN2 | S61 | ochoa | Erlin-2 (Endoplasmic reticulum lipid raft-associated protein 2) (Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2) (SPFH domain-containing protein 2) | Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1 (PubMed:17502376, PubMed:19240031). Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex (PubMed:21343306). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex (PubMed:24217618). {ECO:0000269|PubMed:17502376, ECO:0000269|PubMed:19240031, ECO:0000269|PubMed:21343306, ECO:0000269|PubMed:24217618}. |
| P00533 | EGFR | S768 | psp | Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1) | Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:10805725, PubMed:27153536, PubMed:2790960, PubMed:35538033). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:12297049, PubMed:15611079, PubMed:17909029, PubMed:20837704, PubMed:27153536, PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity). Plays a role in mammalian pain signaling (long-lasting hypersensitivity) (By similarity). {ECO:0000250|UniProtKB:Q01279, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11116146, ECO:0000269|PubMed:11483589, ECO:0000269|PubMed:11602604, ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12873986, ECO:0000269|PubMed:15374980, ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:15611079, ECO:0000269|PubMed:17115032, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:19560417, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:27153536, ECO:0000269|PubMed:2790960, ECO:0000269|PubMed:35538033, ECO:0000269|PubMed:7679104, ECO:0000269|PubMed:8144591, ECO:0000269|PubMed:9419975}.; FUNCTION: Isoform 2 may act as an antagonist of EGF action.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}. |
| P01236 | PRL | S207 | psp | Prolactin (PRL) | Prolactin acts primarily on the mammary gland by promoting lactation. |
| P05455 | SSB | S350 | ochoa | Lupus La protein (La autoantigen) (La ribonucleoprotein) (Sjoegren syndrome type B antigen) (SS-B) | Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation (PubMed:2470590, PubMed:3192525). In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12384597). {ECO:0000269|PubMed:12384597, ECO:0000269|PubMed:2470590, ECO:0000269|PubMed:3192525}. |
| P06730 | EIF4E | S53 | psp | Eukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (eIF-4F 25 kDa subunit) (mRNA cap-binding protein) | Acts in the cytoplasm to initiate and regulate protein synthesis and is required in the nucleus for export of a subset of mRNAs from the nucleus to the cytoplasm which promotes processes such as RNA capping, processing and splicing (PubMed:11606200, PubMed:22578813, PubMed:22684010, PubMed:24335285, PubMed:29987188). Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (By similarity). This protein recognizes and binds the 7-methylguanosine (m7G)-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures (PubMed:16271312, PubMed:22578813). Together with EIF4G1, antagonizes the scanning promoted by EIF1-EIF4G1 and is required for TISU translation, a process where the TISU element recognition makes scanning unnecessary (PubMed:29987188). In addition to its role in translation initiation, also acts as a regulator of translation and stability in the cytoplasm (PubMed:24335285). Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression: in the complex, EIF4E mediates the binding to the mRNA cap (By similarity). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). In P-bodies, component of a complex that mediates the storage of translationally inactive mRNAs in the cytoplasm and prevents their degradation (PubMed:24335285). May play an important role in spermatogenesis through translational regulation of stage-specific mRNAs during germ cell development (By similarity). As well as its roles in translation, also involved in mRNA nucleocytoplasmic transport (By similarity). Its role in mRNA export from the nucleus to the cytoplasm relies on its ability to bind the m7G cap of RNAs and on the presence of the 50-nucleotide EIF4E sensitivity element (4ESE) in the 3'UTR of sensitive transcripts (By similarity). Interaction with the 4ESE is mediated by LRPPRC which binds simultaneously to both EIF4E and the 4ESE, thereby acting as a platform for assembly for the RNA export complex (By similarity). EIF4E-dependent mRNA export is independent of ongoing protein or RNA synthesis and is also NFX1-independent but is XPO1-dependent with LRPPRC interacting with XPO1 to form an EIF4E-dependent mRNA export complex (By similarity). Alters the composition of the cytoplasmic face of the nuclear pore to promote RNA export by reducing RANBP2 expression, relocalizing nucleoporin NUP214 and increasing expression of RANBP1 and RNA export factors DDX19 and GLE1 (By similarity). Promotes the nuclear export of cyclin CCND1 mRNA (By similarity). Promotes the nuclear export of NOS2/iNOS mRNA (PubMed:23471078). Promotes the nuclear export of MDM2 mRNA (PubMed:22684010). Promotes the export of additional mRNAs, including others involved in the cell cycle (By similarity). In the nucleus, binds to capped splice factor-encoding mRNAs and stimulates their nuclear export to enhance splice factor production by increasing their cytoplasmic availability to the translation machinery (By similarity). May also regulate splicing through interaction with the spliceosome in an RNA and m7G cap-dependent manner (By similarity). Also binds to some pre-mRNAs and may play a role in their recruitment to the spliceosome (By similarity). Promotes steady-state capping of a subset of coding and non-coding RNAs by mediating nuclear export of capping machinery mRNAs including RNMT, RNGTT and RAMAC to enhance their translation (By similarity). Stimulates mRNA 3'-end processing by promoting the expression of several core cleavage complex factors required for mRNA cleavage and polyadenylation, and may also have a direct effect through its interaction with the CPSF3 cleavage enzyme (By similarity). Rescues cells from apoptosis by promoting activation of serine/threonine-protein kinase AKT1 through mRNA export of NBS1 which potentiates AKT1 phosphorylation and also through mRNA export of AKT1 effectors, allowing for increased production of these proteins (By similarity). {ECO:0000250|UniProtKB:P63073, ECO:0000250|UniProtKB:P63074, ECO:0000269|PubMed:11606200, ECO:0000269|PubMed:16271312, ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:22684010, ECO:0000269|PubMed:23471078, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:29987188}. |
| P08047 | SP1 | S376 | ochoa | Transcription factor Sp1 | Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Also binds the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component BMAL1 (PubMed:10391891, PubMed:11371615, PubMed:11904305, PubMed:14593115, PubMed:16377629, PubMed:16478997, PubMed:16943418, PubMed:17049555, PubMed:18171990, PubMed:18199680, PubMed:18239466, PubMed:18513490, PubMed:18619531, PubMed:19193796, PubMed:20091743, PubMed:21046154, PubMed:21798247). Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays a role in protecting cells against oxidative stress following brain injury by regulating the expression of RNF112 (By similarity). {ECO:0000250|UniProtKB:O89090, ECO:0000250|UniProtKB:Q01714, ECO:0000269|PubMed:10391891, ECO:0000269|PubMed:11371615, ECO:0000269|PubMed:11904305, ECO:0000269|PubMed:14593115, ECO:0000269|PubMed:16377629, ECO:0000269|PubMed:16478997, ECO:0000269|PubMed:16943418, ECO:0000269|PubMed:17049555, ECO:0000269|PubMed:18171990, ECO:0000269|PubMed:18199680, ECO:0000269|PubMed:18239466, ECO:0000269|PubMed:18513490, ECO:0000269|PubMed:18619531, ECO:0000269|PubMed:19193796, ECO:0000269|PubMed:20091743, ECO:0000269|PubMed:21046154, ECO:0000269|PubMed:21798247}. |
| P08240 | SRPRA | S46 | ochoa | Signal recognition particle receptor subunit alpha (SR-alpha) (Docking protein alpha) (DP-alpha) | Component of the signal recognition particle (SRP) complex receptor (SR) (PubMed:16439358). Ensures, in conjunction with the SRP complex, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (PubMed:16675701, PubMed:34020957). Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SRP subunit SRP54 (PubMed:34020957). SRP receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER (PubMed:34020957). {ECO:0000269|PubMed:16439358, ECO:0000269|PubMed:16675701, ECO:0000269|PubMed:34020957}. |
| P10244 | MYBL2 | S401 | ochoa | Myb-related protein B (B-Myb) (Myb-like protein 2) | Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene. {ECO:0000269|PubMed:10770937}. |
| P12268 | IMPDH2 | S444 | ochoa | Inosine-5'-monophosphate dehydrogenase 2 (IMP dehydrogenase 2) (IMPD 2) (IMPDH 2) (EC 1.1.1.205) (Inosine-5'-monophosphate dehydrogenase type II) (IMP dehydrogenase II) (IMPDH-II) | Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (PubMed:7763314, PubMed:7903306). Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism (PubMed:14766016). It may also have a role in the development of malignancy and the growth progression of some tumors. {ECO:0000269|PubMed:14766016, ECO:0000269|PubMed:7763314, ECO:0000269|PubMed:7903306}. |
| P18583 | SON | S2357 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
| P22695 | UQCRC2 | S303 | ochoa | Cytochrome b-c1 complex subunit 2, mitochondrial (Complex III subunit 2) (Core protein II) (Ubiquinol-cytochrome-c reductase complex core protein 2) | Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (By similarity). The 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2 are homologous to the 2 mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP respectively, and they seem to have preserved their MPP processing properties (By similarity). May be involved in the in situ processing of UQCRFS1 into the mature Rieske protein and its mitochondrial targeting sequence (MTS)/subunit 9 when incorporated into complex III (Probable). {ECO:0000250|UniProtKB:P07257, ECO:0000250|UniProtKB:P23004, ECO:0000305|PubMed:29243944}. |
| P28288 | ABCD3 | S40 | ochoa | ATP-binding cassette sub-family D member 3 (EC 3.1.2.-) (EC 7.6.2.-) (70 kDa peroxisomal membrane protein) (PMP70) | Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that catalyzes the transport of long-chain fatty acids (LCFA)-CoA, dicarboxylic acids-CoA, long-branched-chain fatty acids-CoA and bile acids from the cytosol to the peroxisome lumen for beta-oxydation (PubMed:11248239, PubMed:24333844, PubMed:25168382, PubMed:29397936). Has fatty acyl-CoA thioesterase and ATPase activities (PubMed:29397936). Probably hydrolyzes fatty acyl-CoAs into free fatty acids prior to their ATP-dependent transport into peroxisomes (By similarity). Thus, play a role in regulation of LCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation (PubMed:24333844, PubMed:25944712). {ECO:0000250|UniProtKB:P33897, ECO:0000269|PubMed:11248239, ECO:0000269|PubMed:24333844, ECO:0000269|PubMed:25168382, ECO:0000269|PubMed:25944712, ECO:0000269|PubMed:29397936}. |
| P38935 | IGHMBP2 | S279 | ochoa | DNA-binding protein SMUBP-2 (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent helicase IGHMBP2) (Glial factor 1) (GF-1) (Immunoglobulin mu-binding protein 2) | 5' to 3' helicase that unwinds RNA and DNA duplexes in an ATP-dependent reaction (PubMed:19158098, PubMed:22999958, PubMed:30218034). Specific to 5'-phosphorylated single-stranded guanine-rich sequences (PubMed:22999958, PubMed:8349627). May play a role in RNA metabolism, ribosome biogenesis or initiation of translation (PubMed:19158098, PubMed:19299493). May play a role in regulation of transcription (By similarity). Interacts with tRNA-Tyr (PubMed:19299493). {ECO:0000250|UniProtKB:Q9EQN5, ECO:0000269|PubMed:19158098, ECO:0000269|PubMed:19299493, ECO:0000269|PubMed:22999958, ECO:0000269|PubMed:30218034, ECO:0000269|PubMed:8349627}. |
| P42575 | CASP2 | S139 | psp | Caspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] | Is a regulator of the cascade of caspases responsible for apoptosis execution (PubMed:11156409, PubMed:15073321, PubMed:8087842). Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival (PubMed:15073321). Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress (PubMed:15073321). {ECO:0000269|PubMed:11156409, ECO:0000269|PubMed:15073321, ECO:0000269|PubMed:8087842}.; FUNCTION: [Isoform 1]: Acts as a positive regulator of apoptosis. {ECO:0000269|PubMed:8087842}.; FUNCTION: [Isoform 2]: Acts as a negative regulator of apoptosis. {ECO:0000269|PubMed:8087842}.; FUNCTION: [Isoform 3]: May function as an endogenous apoptosis inhibitor that antagonizes caspase activation and cell death. {ECO:0000269|PubMed:11156409}. |
| P43243 | MATR3 | S35 | ochoa | Matrin-3 | May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32245947}. |
| P46013 | MKI67 | S648 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46934 | NEDD4 | S467 | ochoa | E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates 'Lys-63' in target proteins (PubMed:19920177, PubMed:21399620, PubMed:23644597). Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes (By similarity). Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes (PubMed:21765395). Promotes ubiquitination of RAPGEF2 (PubMed:11598133). According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD (By similarity). Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development (By similarity). Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2 (PubMed:20086093). Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Ubiquitinates DAZAP2, leading to its proteasomal degradation (PubMed:11342538). Ubiquitinates POLR2A (PubMed:19920177). Functions as a platform to recruit USP13 to form an NEDD4-USP13 deubiquitination complex that plays a critical role in cleaving the 'Lys-48'-linked ubiquitin chains of VPS34 and then stabilizing VPS34, thus promoting the formation of autophagosomes (PubMed:32101753). {ECO:0000250|UniProtKB:P46935, ECO:0000269|PubMed:11342538, ECO:0000269|PubMed:11598133, ECO:0000269|PubMed:17218260, ECO:0000269|PubMed:18562292, ECO:0000269|PubMed:21399620, ECO:0000269|PubMed:21765395, ECO:0000269|PubMed:23644597, ECO:0000269|PubMed:25631046, ECO:0000269|PubMed:32101753}.; FUNCTION: (Microbial infection) Involved in the ubiquitination of Ebola virus protein VP40 which plays a role in viral budding. {ECO:0000269|PubMed:12559917, ECO:0000269|PubMed:18305167}. |
| P69849 | NOMO3 | S1205 | ochoa | BOS complex subunit NOMO3 (Nodal modulator 3) (pM5 protein 3) | Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (PubMed:32820719, PubMed:36261522). The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (PubMed:36261522). {ECO:0000269|PubMed:32820719, ECO:0000269|PubMed:36261522}. |
| Q02446 | SP4 | S216 | ochoa | Transcription factor Sp4 (SPR-1) | Binds to GT and GC boxes promoters elements. Probable transcriptional activator. |
| Q02543 | RPL18A | S58 | ochoa | Large ribosomal subunit protein eL20 (60S ribosomal protein L18a) | Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| Q03252 | LMNB2 | S175 | ochoa | Lamin-B2 | Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:33033404). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:33033404). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:33033404). {ECO:0000269|PubMed:33033404}. |
| Q05655 | PRKCD | S658 | ochoa | Protein kinase C delta type (EC 2.7.11.13) (Tyrosine-protein kinase PRKCD) (EC 2.7.10.2) (nPKC-delta) [Cleaved into: Protein kinase C delta type regulatory subunit; Protein kinase C delta type catalytic subunit (Sphingosine-dependent protein kinase-1) (SDK1)] | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression as well as survival of several cancers, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses (PubMed:21406692, PubMed:21810427). Negatively regulates B cell proliferation and also has an important function in self-antigen induced B cell tolerance induction (By similarity). Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene transcription and apoptosis (PubMed:21406692, PubMed:21810427). In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus, causing the phosphorylation of p53/TP53 (PubMed:21406692, PubMed:21810427). In the case of ER stress or DNA damage-induced apoptosis, can form a complex with the tyrosine-protein kinase ABL1 which trigger apoptosis independently of p53/TP53 (PubMed:21406692, PubMed:21810427). In cytosol can trigger apoptosis by activating MAPK11 or MAPK14, inhibiting AKT1 and decreasing the level of X-linked inhibitor of apoptosis protein (XIAP), whereas in nucleus induces apoptosis via the activation of MAPK8 or MAPK9. Upon ionizing radiation treatment, is required for the activation of the apoptosis regulators BAX and BAK, which trigger the mitochondrial cell death pathway. Can phosphorylate MCL1 and target it for degradation which is sufficient to trigger for BAX activation and apoptosis. Is required for the control of cell cycle progression both at G1/S and G2/M phases. Mediates phorbol 12-myristate 13-acetate (PMA)-induced inhibition of cell cycle progression at G1/S phase by up-regulating the CDK inhibitor CDKN1A/p21 and inhibiting the cyclin CCNA2 promoter activity. In response to UV irradiation can phosphorylate CDK1, which is important for the G2/M DNA damage checkpoint activation (By similarity). Can protect glioma cells from the apoptosis induced by TNFSF10/TRAIL, probably by inducing increased phosphorylation and subsequent activation of AKT1 (PubMed:15774464). Is highly expressed in a number of cancer cells and promotes cell survival and resistance against chemotherapeutic drugs by inducing cyclin D1 (CCND1) and hyperphosphorylation of RB1, and via several pro-survival pathways, including NF-kappa-B, AKT1 and MAPK1/3 (ERK1/2). Involved in antifungal immunity by mediating phosphorylation and activation of CARD9 downstream of C-type lectin receptors activation, promoting interaction between CARD9 and BCL10, followed by activation of NF-kappa-B and MAP kinase p38 pathways (By similarity). Can also act as tumor suppressor upon mitogenic stimulation with PMA or TPA. In N-formyl-methionyl-leucyl-phenylalanine (fMLP)-treated cells, is required for NCF1 (p47-phox) phosphorylation and activation of NADPH oxidase activity, and regulates TNF-elicited superoxide anion production in neutrophils, by direct phosphorylation and activation of NCF1 or indirectly through MAPK1/3 (ERK1/2) signaling pathways (PubMed:19801500). May also play a role in the regulation of NADPH oxidase activity in eosinophil after stimulation with IL5, leukotriene B4 or PMA (PubMed:11748588). In collagen-induced platelet aggregation, acts a negative regulator of filopodia formation and actin polymerization by interacting with and negatively regulating VASP phosphorylation (PubMed:16940418). Downstream of PAR1, PAR4 and CD36/GP4 receptors, regulates differentially platelet dense granule secretion; acts as a positive regulator in PAR-mediated granule secretion, whereas it negatively regulates CD36/GP4-mediated granule release (PubMed:19587372). Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin (PubMed:11877440). The catalytic subunit phosphorylates 14-3-3 proteins (YWHAB, YWHAZ and YWHAH) in a sphingosine-dependent fashion (By similarity). Phosphorylates ELAVL1 in response to angiotensin-2 treatment (PubMed:18285462). Phosphorylates mitochondrial phospholipid scramblase 3 (PLSCR3), resulting in increased cardiolipin expression on the mitochondrial outer membrane which facilitates apoptosis (PubMed:12649167). Phosphorylates SMPD1 which induces SMPD1 secretion (PubMed:17303575). {ECO:0000250|UniProtKB:P28867, ECO:0000269|PubMed:11748588, ECO:0000269|PubMed:11877440, ECO:0000269|PubMed:12649167, ECO:0000269|PubMed:15774464, ECO:0000269|PubMed:16940418, ECO:0000269|PubMed:17303575, ECO:0000269|PubMed:18285462, ECO:0000269|PubMed:19587372, ECO:0000269|PubMed:19801500, ECO:0000303|PubMed:21406692, ECO:0000303|PubMed:21810427}. |
| Q09472 | EP300 | S1716 | ochoa | Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-) | Functions as a histone acetyltransferase and regulates transcription via chromatin remodeling (PubMed:23415232, PubMed:23934153, PubMed:8945521). Acetylates all four core histones in nucleosomes (PubMed:23415232, PubMed:23934153, PubMed:8945521). Histone acetylation gives an epigenetic tag for transcriptional activation (PubMed:23415232, PubMed:23934153, PubMed:8945521). Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (PubMed:23415232). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905, PubMed:23911289). Also able to acetylate histone lysine residues that are already monomethylated on the same side chain to form N6-acetyl-N6-methyllysine (Kacme), an epigenetic mark of active chromatin associated with increased transcriptional initiation (PubMed:37731000). Catalyzes formation of histone H4 acetyl-methylated at 'Lys-5' and 'Lys-12' (H4K5acme and H4K12acme, respectively) (PubMed:37731000). Also functions as acetyltransferase for non-histone targets, such as ALX1, HDAC1, PRMT1, SIRT2, STAT3 or GLUL (PubMed:12929931, PubMed:15653507, PubMed:16285960, PubMed:16762839, PubMed:18722353, PubMed:18782771, PubMed:26990986). Acetylates 'Lys-131' of ALX1 and acts as its coactivator (PubMed:12929931). Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of p53/TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function (PubMed:18722353). Following DNA damage, forms a stress-responsive p53/TP53 coactivator complex with JMY which mediates p53/TP53 acetylation, thereby increasing p53/TP53-dependent transcription and apoptosis (PubMed:11511361, PubMed:15448695). Promotes chromatin acetylation in heat shock responsive HSP genes during the heat shock response (HSR), thereby stimulating HSR transcription (PubMed:18451878). Acetylates HDAC1 leading to its inactivation and modulation of transcription (PubMed:16762839). Acetylates 'Lys-247' of EGR2 (By similarity). Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2 (PubMed:12586840). Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement (PubMed:14752053). Can also mediate transcriptional repression. Acetylates FOXO1 and enhances its transcriptional activity (PubMed:15890677). Acetylates STAT3 at different sites, promoting both STAT3 dimerization and activation and recruitment to chromatin (PubMed:15653507, PubMed:16285960, PubMed:18782771). Acetylates BCL6 which disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity (PubMed:12402037). Participates in CLOCK or NPAS2-regulated rhythmic gene transcription; exhibits a circadian association with CLOCK or NPAS2, correlating with increase in PER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter (PubMed:14645221). Acetylates MTA1 at 'Lys-626' which is essential for its transcriptional coactivator activity (PubMed:16617102). Acetylates XBP1 isoform 2; acetylation increases protein stability of XBP1 isoform 2 and enhances its transcriptional activity (PubMed:20955178). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates MEF2D (PubMed:21030595). Acetylates and stabilizes ZBTB7B protein by antagonizing ubiquitin conjugation and degradation, this mechanism may be involved in CD4/CD8 lineage differentiation (PubMed:20810990). Acetylates GABPB1, impairing GABPB1 heterotetramerization and activity (By similarity). Acetylates PCK1 and promotes PCK1 anaplerotic activity (PubMed:30193097). Acetylates RXRA and RXRG (PubMed:17761950). Acetylates isoform M2 of PKM (PKM2), promoting its homodimerization and conversion into a protein kinase (PubMed:24120661). Acetylates RPTOR in response to leucine, leading to activation of the mTORC1 complex (PubMed:30197302, PubMed:32561715). Acetylates RICTOR, leading to activation of the mTORC2 complex (PubMed:22084251). Mediates cAMP-gene regulation by binding specifically to phosphorylated CREBBP (PubMed:8917528). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA), butanoyl-CoA (butyryl-CoA), 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA), lactoyl-CoA or propanoyl-CoA (propionyl-CoA), and is able to mediate protein crotonylation, butyrylation, 2-hydroxyisobutyrylation, lactylation or propionylation, respectively (PubMed:17267393, PubMed:25818647, PubMed:29775581, PubMed:31645732). Acts as a histone crotonyltransferase; crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25818647). Histone crotonyltransferase activity is dependent on the concentration of (2E)-butenoyl-CoA (crotonyl-CoA) substrate and such activity is weak when (2E)-butenoyl-CoA (crotonyl-CoA) concentration is low (PubMed:25818647). Also acts as a histone butyryltransferase; butyrylation marks active promoters (PubMed:17267393). Catalyzes histone lactylation in macrophages by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription (PubMed:31645732). Acts as a protein-lysine 2-hydroxyisobutyryltransferase; regulates glycolysis by mediating 2-hydroxyisobutyrylation of glycolytic enzymes (PubMed:29775581). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000250|UniProtKB:B2RWS6, ECO:0000269|PubMed:10733570, ECO:0000269|PubMed:11430825, ECO:0000269|PubMed:11511361, ECO:0000269|PubMed:11701890, ECO:0000269|PubMed:12402037, ECO:0000269|PubMed:12586840, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:14752053, ECO:0000269|PubMed:15186775, ECO:0000269|PubMed:15448695, ECO:0000269|PubMed:15653507, ECO:0000269|PubMed:15890677, ECO:0000269|PubMed:16285960, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:16762839, ECO:0000269|PubMed:17267393, ECO:0000269|PubMed:17761950, ECO:0000269|PubMed:18451878, ECO:0000269|PubMed:18722353, ECO:0000269|PubMed:18782771, ECO:0000269|PubMed:18995842, ECO:0000269|PubMed:20810990, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:22084251, ECO:0000269|PubMed:23415232, ECO:0000269|PubMed:23911289, ECO:0000269|PubMed:23934153, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:25818647, ECO:0000269|PubMed:26990986, ECO:0000269|PubMed:29775581, ECO:0000269|PubMed:30193097, ECO:0000269|PubMed:30197302, ECO:0000269|PubMed:31645732, ECO:0000269|PubMed:32561715, ECO:0000269|PubMed:37731000, ECO:0000269|PubMed:8917528, ECO:0000269|PubMed:8945521, ECO:0000305|PubMed:20955178}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. {ECO:0000269|PubMed:10545121, ECO:0000269|PubMed:11080476}. |
| Q12774 | ARHGEF5 | S1019 | ochoa | Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM) | Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity). {ECO:0000250|UniProtKB:E9Q7D5, ECO:0000269|PubMed:14662653, ECO:0000269|PubMed:15601624}. |
| Q13823 | GNL2 | S68 | ochoa | Nucleolar GTP-binding protein 2 (Autoantigen NGP-1) | GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (PubMed:32669547). May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels (PubMed:26203195). {ECO:0000269|PubMed:26203195, ECO:0000269|PubMed:32669547}. |
| Q14324 | MYBPC2 | S884 | ochoa | Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform) | Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. |
| Q15075 | EEA1 | S70 | ochoa | Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2) | Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking. |
| Q15155 | NOMO1 | S1205 | ochoa | BOS complex subunit NOMO1 (Nodal modulator 1) (pM5 protein) | Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (PubMed:32820719, PubMed:36261522). The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (PubMed:36261522). {ECO:0000269|PubMed:32820719, ECO:0000269|PubMed:36261522}. |
| Q15437 | SEC23B | S186 | psp | Protein transport protein Sec23B (hSec23B) (SEC23-related protein B) | Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. {ECO:0000250|UniProtKB:Q15436}. |
| Q15911 | ZFHX3 | S1353 | ochoa | Zinc finger homeobox protein 3 (AT motif-binding factor 1) (AT-binding transcription factor 1) (Alpha-fetoprotein enhancer-binding protein) (Zinc finger homeodomain protein 3) (ZFH-3) | Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3 (PubMed:25105025). Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain (By similarity). Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression (PubMed:11312261). Down-regulates the MUC5AC promoter in gastric cancer (PubMed:17330845). In association with RUNX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). Inhibits estrogen receptor (ESR1) function by selectively competing with coactivator NCOA3 for binding to ESR1 in ESR1-positive breast cancer cells (PubMed:20720010). {ECO:0000250|UniProtKB:Q61329, ECO:0000269|PubMed:11312261, ECO:0000269|PubMed:17330845, ECO:0000269|PubMed:20599712, ECO:0000269|PubMed:20720010, ECO:0000269|PubMed:25105025}. |
| Q1KMD3 | HNRNPUL2 | S543 | ochoa | Heterogeneous nuclear ribonucleoprotein U-like protein 2 (Scaffold-attachment factor A2) (SAF-A2) | None |
| Q4KMQ2 | ANO6 | S238 | ochoa | Anoctamin-6 (Small-conductance calcium-activated nonselective cation channel) (SCAN channel) (Transmembrane protein 16F) | Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts (PubMed:20056604, PubMed:21107324, PubMed:21908539, PubMed:22006324, PubMed:22946059). Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization (By similarity). Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes (By similarity). {ECO:0000250|UniProtKB:Q6P9J9, ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:21107324, ECO:0000269|PubMed:21908539, ECO:0000269|PubMed:22006324, ECO:0000269|PubMed:22946059}.; FUNCTION: (Microbial infection) Upon SARS coronavirus-2/SARS-CoV-2 infection, is activated by spike protein which increases the amplitude of spontaneous Ca(2+) signals and is required for spike-mediated syncytia. {ECO:0000269|PubMed:33827113}. |
| Q53QZ3 | ARHGAP15 | S246 | ochoa | Rho GTPase-activating protein 15 (ArhGAP15) (Rho-type GTPase-activating protein 15) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction. {ECO:0000269|PubMed:12650940}. |
| Q5JPE7 | NOMO2 | S1205 | ochoa | BOS complex subunit NOMO2 (Nodal modulator 2) (pM5 protein 2) | Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (PubMed:32820719, PubMed:36261522). The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (PubMed:36261522). {ECO:0000269|PubMed:32820719, ECO:0000269|PubMed:36261522}. |
| Q6F5E8 | CARMIL2 | S1156 | ochoa | Capping protein, Arp2/3 and myosin-I linker protein 2 (Capping protein regulator and myosin 1 linker 2) (F-actin-uncapping protein RLTPR) (Leucine-rich repeat-containing protein 16C) (RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein) | Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization (PubMed:26466680). Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations (PubMed:19846667, PubMed:26466680, PubMed:26578515). Involved as well in cell migration and invadopodia formation during wound healing (PubMed:19846667, PubMed:26466680, PubMed:26578515). Required for CD28-mediated stimulation of NF-kappa-B signaling, involved in naive T cells activation, maturation into T memory cells, and differentiation into T helper and T regulatory cells (PubMed:27647348, PubMed:27647349, PubMed:28112205). {ECO:0000269|PubMed:19846667, ECO:0000269|PubMed:26466680, ECO:0000269|PubMed:26578515, ECO:0000269|PubMed:27647348, ECO:0000269|PubMed:27647349, ECO:0000269|PubMed:28112205}. |
| Q6P0N0 | MIS18BP1 | S739 | ochoa | Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243) | Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038, ECO:0000269|PubMed:17339379}. |
| Q6P6C2 | ALKBH5 | S312 | ochoa | RNA demethylase ALKBH5 (EC 1.14.11.53) (Alkylated DNA repair protein alkB homolog 5) (Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5) | Dioxygenase that specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:23177736, PubMed:24489119, PubMed:24616105, PubMed:24778178, PubMed:34048572, PubMed:36944332, PubMed:37257451, PubMed:37369679). Demethylates RNA by oxidative demethylation, which requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:21264265, PubMed:23177736, PubMed:24489119, PubMed:24616105, PubMed:24778178). Demethylation of m6A mRNA affects mRNA processing, translation and export (PubMed:23177736, PubMed:34048572, PubMed:36944332, PubMed:37257451). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro) (PubMed:24616105). Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round spermatids: m6A demethylation of target transcripts is required for correct splicing and the production of longer 3'-UTR mRNAs in male germ cells (By similarity). Involved in paraspeckle assembly, a nuclear membraneless organelle, by undergoing liquid-liquid phase separation (PubMed:37369679, PubMed:37474102). Paraspeckle assembly is coupled with m6A demethylation of RNAs, such as NEAT1 non-coding RNA (PubMed:37474102). Also acts as a negative regulator of T-cell development: inhibits gamma-delta T-cell proliferation via demethylation of JAG1 and NOTCH2 transcripts (By similarity). Inhibits regulatory T-cell (Treg) recruitment by mediating demethylation and destabilization of CCL28 mRNAs (By similarity). {ECO:0000250|UniProtKB:Q3TSG4, ECO:0000269|PubMed:21264265, ECO:0000269|PubMed:23177736, ECO:0000269|PubMed:24489119, ECO:0000269|PubMed:24616105, ECO:0000269|PubMed:24778178, ECO:0000269|PubMed:34048572, ECO:0000269|PubMed:36944332, ECO:0000269|PubMed:37257451, ECO:0000269|PubMed:37369679, ECO:0000269|PubMed:37474102}. |
| Q6PCB5 | RSBN1L | S39 | ochoa | Lysine-specific demethylase RSBN1L (EC 1.14.11.-) (Round spermatid basic protein 1-like protein) | Lysine-specific demethylase that specifically demethylates methylated lysine residues of proteins. {ECO:0000250|UniProtKB:Q80T69}. |
| Q6PGN9 | PSRC1 | S98 | ochoa | Proline/serine-rich coiled-coil protein 1 | Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression. {ECO:0000269|PubMed:18411309, ECO:0000269|PubMed:19738423, ECO:0000269|PubMed:26820536}. |
| Q6UUV9 | CRTC1 | S73 | ochoa | CREB-regulated transcription coactivator 1 (Mucoepidermoid carcinoma translocated protein 1) (Transducer of regulated cAMP response element-binding protein 1) (TORC-1) (Transducer of CREB protein 1) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock. {ECO:0000250|UniProtKB:Q157S1, ECO:0000250|UniProtKB:Q68ED7, ECO:0000269|PubMed:23699513}.; FUNCTION: (Microbial infection) Plays a role of coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:16809310}. |
| Q6ZN28 | MACC1 | S116 | ochoa | Metastasis-associated in colon cancer protein 1 (SH3 domain-containing protein 7a5) | Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo. {ECO:0000269|PubMed:19098908}. |
| Q7L591 | DOK3 | S439 | ochoa | Docking protein 3 (Downstream of tyrosine kinase 3) | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity). {ECO:0000250}. |
| Q7Z417 | NUFIP2 | S212 | ochoa | FMR1-interacting protein NUFIP2 (82 kDa FMRP-interacting protein) (82-FIP) (Cell proliferation-inducing gene 1 protein) (FMRP-interacting protein 2) (Nuclear FMR1-interacting protein 2) | Binds RNA. {ECO:0000269|PubMed:12837692}. |
| Q7Z4S6 | KIF21A | S1304 | ochoa | Kinesin-like protein KIF21A (Kinesin-like protein KIF2) (Renal carcinoma antigen NY-REN-62) | Processive microtubule plus-end directed motor protein involved in neuronal axon guidance. Is recruited by KANK1 to cortical microtubule stabilizing complexes (CMSCs) at focal adhesions (FAs) rims where it promotes microtubule capture and stability. Controls microtubule polymerization rate at axonal growth cones and suppresses microtubule growth without inducing microtubule disassembly once it reaches the cell cortex. {ECO:0000250|UniProtKB:Q9QXL2, ECO:0000269|PubMed:24120883}. |
| Q86VP6 | CAND1 | S122 | ochoa | Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (TBP-interacting protein of 120 kDa A) (TBP-interacting protein 120A) (p120 CAND1) | Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes. {ECO:0000269|PubMed:12504025, ECO:0000269|PubMed:12504026, ECO:0000269|PubMed:12609982, ECO:0000269|PubMed:16449638, ECO:0000269|PubMed:21249194, ECO:0000269|PubMed:23453757}. |
| Q86VS8 | HOOK3 | S690 | ochoa | Protein Hook homolog 3 (h-hook3) (hHK3) | Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Predominantly recruits 2 dyneins, which increases both the force and speed of the microtubule motor (PubMed:25035494, PubMed:33734450). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). {ECO:0000250|UniProtKB:Q8BUK6, ECO:0000269|PubMed:11238449, ECO:0000269|PubMed:17237231, ECO:0000269|PubMed:18799622, ECO:0000269|PubMed:25035494, ECO:0000269|PubMed:32073997, ECO:0000269|PubMed:33734450}.; FUNCTION: (Microbial infection) May serve as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking. {ECO:0000305}. |
| Q86WG5 | SBF2 | S1129 | ochoa | Myotubularin-related protein 13 (Inactive phosphatidylinositol 3-phosphatase 13) (SET-binding factor 2) | Guanine nucleotide exchange factor (GEF) which activates RAB21 and possibly RAB28 (PubMed:20937701, PubMed:25648148). Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (PubMed:20937701, PubMed:25648148). In response to starvation-induced autophagy, activates RAB21 which in turn binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (PubMed:25648148). Acts as an adapter for the phosphatase MTMR2 (By similarity). Increases MTMR2 catalytic activity towards phosphatidylinositol 3,5-bisphosphate and to a lesser extent towards phosphatidylinositol 3-phosphate (By similarity). {ECO:0000250|UniProtKB:E9PXF8, ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:25648148}. |
| Q8NDX5 | PHC3 | S842 | ochoa | Polyhomeotic-like protein 3 (Early development regulatory protein 3) (Homolog of polyhomeotic 3) (hPH3) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269|PubMed:12167701}. |
| Q8NEV8 | EXPH5 | S341 | ochoa | Exophilin-5 (Synaptotagmin-like protein homolog lacking C2 domains b) (SlaC2-b) (Slp homolog lacking C2 domains b) | May act as Rab effector protein and play a role in vesicle trafficking. |
| Q8NFW8 | CMAS | S395 | ochoa | N-acylneuraminate cytidylyltransferase (EC 2.7.7.43) (CMP-N-acetylneuraminic acid synthase) (CMP-NeuNAc synthase) | Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN). |
| Q8TF01 | PNISR | S393 | ochoa | Arginine/serine-rich protein PNISR (PNN-interacting serine/arginine-rich protein) (SR-related protein) (SR-rich protein) (Serine/arginine-rich-splicing regulatory protein 130) (SRrp130) (Splicing factor, arginine/serine-rich 130) (Splicing factor, arginine/serine-rich 18) | None |
| Q8TF72 | SHROOM3 | S499 | ochoa | Protein Shroom3 (Shroom-related protein) (hShrmL) | Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}. |
| Q92736 | RYR2 | S2031 | psp | Ryanodine receptor 2 (RYR-2) (RyR2) (hRYR-2) (Cardiac muscle ryanodine receptor) (Cardiac muscle ryanodine receptor-calcium release channel) (Type 2 ryanodine receptor) | Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) cytosolic levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development. {ECO:0000269|PubMed:10830164, ECO:0000269|PubMed:17984046, ECO:0000269|PubMed:20056922, ECO:0000269|PubMed:27733687, ECO:0000269|PubMed:33536282}. |
| Q96KM6 | ZNF512B | S409 | ochoa | Zinc finger protein 512B | Involved in transcriptional regulation by repressing gene expression (PubMed:39460621). Associates with the nucleosome remodeling and histone deacetylase (NuRD) complex, which promotes transcriptional repression by histone deacetylation and nucleosome remodeling (PubMed:39460621). {ECO:0000269|PubMed:39460621}. |
| Q96KN1 | LRATD2 | S178 | ochoa | Protein LRATD2 (Breast cancer membrane protein 101) (LRAT domain-containing 2) (Protein FAM84B) (Protein NSE2) | None |
| Q96QT6 | PHF12 | S780 | ochoa | PHD finger protein 12 (PHD factor 1) (Pf1) | Transcriptional repressor acting as key scaffolding subunit of SIN3 complexes which contributes to complex assembly by contacting each core subunit domain, stabilizes the complex and constitutes the substrate receptor by recruiting the H3 histone tail (PubMed:37137925). SIN3 complexes are composed of a SIN3 scaffold subunit, one catalytic core (HDAC1 or HDAC2) and 2 chromatin targeting modules (PubMed:11390640, PubMed:37137925). SIN3B complex represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2 (PubMed:37137925). SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription (PubMed:21041482). May also repress transcription in a SIN3A-independent manner through recruitment of functional TLE5 complexes to DNA (PubMed:11390640). May also play a role in ribosomal biogenesis (By similarity). {ECO:0000250|UniProtKB:Q5SPL2, ECO:0000269|PubMed:11390640, ECO:0000269|PubMed:21041482, ECO:0000269|PubMed:37137925}. |
| Q96RV3 | PCNX1 | S159 | ochoa | Pecanex-like protein 1 (Pecanex homolog protein 1) | None |
| Q96T58 | SPEN | S1485 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q9BSH4 | TACO1 | S156 | ochoa | Translational activator of cytochrome c oxidase 1 (Coiled-coil domain-containing protein 44) (Translational activator of mitochondrially-encoded cytochrome c oxidase I) | Acts as a translational activator of mitochondrially-encoded cytochrome c oxidase 1. {ECO:0000269|PubMed:19503089}. |
| Q9BSW2 | CRACR2A | S26 | ochoa | EF-hand calcium-binding domain-containing protein 4B (Calcium release-activated calcium channel regulator 2A) (CRAC channel regulator 2A) (Calcium release-activated channel regulator 2A) (Ras-related protein Rab-46) (EC 3.6.5.2) | [Isoform 1]: Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex. {ECO:0000269|PubMed:20418871, ECO:0000269|PubMed:27016526}.; FUNCTION: [Isoform 2]: Rab GTPase that mediates the trafficking of Weibel-Palade bodies (WPBs) to microtubule organizing center (MTOC) in endothelial cells in response to acute inflammatory stimuli (PubMed:31092558). During histamine (but not thrombin) stimulation of endothelial cells, the dynein-bound form induces retrograde transport of a subset of WPBs along microtubules to the MTOC in a Ca(2+)-independent manner and its GTPase activity is essential for this function (PubMed:31092558). Ca(2+)-regulated dynein adapter protein that activates dynein-mediated transport and dynein-dynactin motility on microtubules and regulates endosomal trafficking of CD47 (PubMed:30814157). Acts as an intracellular signaling module bridging two important T-cell receptor (TCR) signaling pathways, Ca(2+)-NFAT and JNK, to affect T-cell activation (PubMed:27016526). In resting T-cells, is predominantly localized near TGN network in a GTP-bound form, upon TCR stimulation, localizes at the immunological synapse via interaction with VAV1 to activate downstream Ca(2+)-NFAT and JNK signaling pathways (PubMed:27016526). Plays a role in T-helper 1 (Th1) cell differentiation and T-helper 17 (Th17) cell effector function (PubMed:29987160). Plays a role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation (PubMed:27016526). {ECO:0000269|PubMed:27016526, ECO:0000269|PubMed:29987160, ECO:0000269|PubMed:30814157, ECO:0000269|PubMed:31092558}. |
| Q9BUJ2 | HNRNPUL1 | S512 | ochoa | Heterogeneous nuclear ribonucleoprotein U-like protein 1 (Adenovirus early region 1B-associated protein 5) (E1B-55 kDa-associated protein 5) (E1B-AP5) | Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation. Also plays a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro. {ECO:0000269|PubMed:12489984, ECO:0000269|PubMed:9733834}. |
| Q9BYW2 | SETD2 | S1165 | ochoa | Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) | Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}. |
| Q9H4P4 | RNF41 | S254 | psp | E3 ubiquitin-protein ligase NRDP1 (EC 2.3.2.27) (RING finger protein 41) (RING-type E3 ubiquitin transferase NRDP1) | Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of pro-inflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus (By similarity). Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Also acts as a PRKN modifier that accelerates its degradation, resulting in a reduction of PRKN activity, influencing the balance of intracellular redox state. The RNF41-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control (PubMed:24949970). {ECO:0000250, ECO:0000250|UniProtKB:Q8BH75, ECO:0000269|PubMed:12411582, ECO:0000269|PubMed:14765125, ECO:0000269|PubMed:15632191, ECO:0000269|PubMed:17210635, ECO:0000269|PubMed:18541373, ECO:0000269|PubMed:19483718, ECO:0000269|PubMed:24949970}. |
| Q9HD26 | GOPC | S412 | ochoa | Golgi-associated PDZ and coiled-coil motif-containing protein (CFTR-associated ligand) (Fused in glioblastoma) (PDZ protein interacting specifically with TC10) (PIST) | Plays a role in intracellular protein trafficking and degradation (PubMed:11707463, PubMed:14570915, PubMed:15358775). May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels (By similarity). May also regulate the intracellular trafficking of the ADR1B receptor (PubMed:15358775). May play a role in autophagy (By similarity). Together with MARCHF2 mediates the ubiquitination and lysosomal degradation of CFTR (PubMed:23818989). Overexpression results in CFTR intracellular retention and lysosomaldegradation in the lysosomes (PubMed:11707463, PubMed:14570915). {ECO:0000250|UniProtKB:Q8BH60, ECO:0000269|PubMed:11707463, ECO:0000269|PubMed:14570915, ECO:0000269|PubMed:15358775, ECO:0000269|PubMed:23818989}. |
| Q9NQ86 | TRIM36 | S620 | ochoa | E3 ubiquitin-protein ligase TRIM36 (EC 2.3.2.27) (RING finger protein 98) (RING-type E3 ubiquitin transferase TRIM36) (Tripartite motif-containing protein 36) (Zinc-binding protein Rbcc728) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation (PubMed:28087737). May play a role in the acrosome reaction and fertilization. {ECO:0000250|UniProtKB:Q80WG7, ECO:0000269|PubMed:28087737}. |
| Q9NYL2 | MAP3K20 | S268 | ochoa | Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase 7) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) | Stress-activated component of a protein kinase signal transduction cascade that promotes programmed cell death in response to various stress, such as ribosomal stress, osmotic shock and ionizing radiation (PubMed:10924358, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15350844, PubMed:15737997, PubMed:18331592, PubMed:20559024, PubMed:26999302, PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts by catalyzing phosphorylation of MAP kinase kinases, leading to activation of the JNK (MAPK8/JNK1, MAPK9/JNK2 and/or MAPK10/JNK3) and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11042189, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15172994, PubMed:15737997, PubMed:32289254, PubMed:32610081, PubMed:35857590). Activates JNK through phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7, and MAP kinase p38 gamma (MAPK12) via phosphorylation of MAP2K3/MKK3 and MAP2K6/MKK6 (PubMed:11836244, PubMed:12220515). Involved in stress associated with adrenergic stimulation: contributes to cardiac decompensation during periods of acute cardiac stress (PubMed:15350844, PubMed:21224381, PubMed:27859413). May be involved in regulation of S and G2 cell cycle checkpoint by mediating phosphorylation of CHEK2 (PubMed:15342622). {ECO:0000269|PubMed:10924358, ECO:0000269|PubMed:11042189, ECO:0000269|PubMed:11836244, ECO:0000269|PubMed:12220515, ECO:0000269|PubMed:14521931, ECO:0000269|PubMed:15172994, ECO:0000269|PubMed:15342622, ECO:0000269|PubMed:15350844, ECO:0000269|PubMed:15737997, ECO:0000269|PubMed:18331592, ECO:0000269|PubMed:20559024, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:26999302, ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKalpha]: Key component of the stress-activated protein kinase signaling cascade in response to ribotoxic stress or UV-B irradiation (PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts as the proximal sensor of ribosome collisions during the ribotoxic stress response (RSR): directly binds to the ribosome by inserting its flexible C-terminus into the ribosomal intersubunit space, thereby acting as a sentinel for colliding ribosomes (PubMed:32289254, PubMed:32610081). Upon ribosome collisions, activates either the stress-activated protein kinase signal transduction cascade or the integrated stress response (ISR), leading to programmed cell death or cell survival, respectively (PubMed:32610081). Dangerous levels of ribosome collisions trigger the autophosphorylation and activation of MAP3K20, which dissociates from colliding ribosomes and phosphorylates MAP kinase kinases, leading to activation of the JNK and MAP kinase p38 pathways that promote programmed cell death (PubMed:32289254, PubMed:32610081). Less dangerous levels of ribosome collisions trigger the integrated stress response (ISR): MAP3K20 activates EIF2AK4/GCN2 independently of its protein-kinase activity, promoting EIF2AK4/GCN2-mediated phosphorylation of EIF2S1/eIF-2-alpha (PubMed:32610081). Also part of the stress-activated protein kinase signaling cascade triggering the NLRP1 inflammasome in response to UV-B irradiation: ribosome collisions activate MAP3K20, which directly phosphorylates NLRP1, leading to activation of the NLRP1 inflammasome and subsequent pyroptosis (PubMed:35857590). NLRP1 is also phosphorylated by MAP kinase p38 downstream of MAP3K20 (PubMed:35857590). Also acts as a histone kinase by phosphorylating histone H3 at 'Ser-28' (H3S28ph) (PubMed:15684425). {ECO:0000269|PubMed:15684425, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKbeta]: Isoform that lacks the C-terminal region that mediates ribosome-binding: does not act as a sensor of ribosome collisions in response to ribotoxic stress (PubMed:32289254, PubMed:32610081, PubMed:35857590). May act as an antagonist of isoform ZAKalpha: interacts with isoform ZAKalpha, leading to decrease the expression of isoform ZAKalpha (PubMed:27859413). {ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}. |
| Q9NZN5 | ARHGEF12 | S22 | ochoa | Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. {ECO:0000269|PubMed:11094164}. |
| Q9P260 | RELCH | S419 | ochoa | RAB11-binding protein RELCH (LisH domain and HEAT repeat-containing protein KIAA1468) (RAB11 binding and LisH domain, coiled-coil and HEAT repeat-containing) (RAB11-binding protein containing LisH, coiled-coil, and HEAT repeats) | Regulates intracellular cholesterol distribution from recycling endosomes to the trans-Golgi network through interactions with RAB11 and OSBP (PubMed:29514919). Functions in membrane tethering and promotes OSBP-mediated cholesterol transfer between RAB11-bound recycling endosomes and OSBP-bound Golgi-like membranes (PubMed:29514919). {ECO:0000269|PubMed:29514919}. |
| Q9ULW2 | FZD10 | S553 | ochoa | Frizzled-10 (Fz-10) (hFz10) (FzE7) (CD antigen CD350) | Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). {ECO:0000250|UniProtKB:Q8BKG4, ECO:0000305}. |
| Q9Y6K1 | DNMT3A | S393 | psp | DNA (cytosine-5)-methyltransferase 3A (Dnmt3a) (EC 2.1.1.37) (Cysteine methyltransferase DNMT3A) (EC 2.1.1.-) (DNA methyltransferase HsaIIIA) (DNA MTase HsaIIIA) (M.HsaIIIA) | Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development (PubMed:12138111, PubMed:16357870, PubMed:30478443). DNA methylation is coordinated with methylation of histones (PubMed:12138111, PubMed:16357870, PubMed:30478443). It modifies DNA in a non-processive manner and also methylates non-CpG sites (PubMed:12138111, PubMed:16357870, PubMed:30478443). May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1 (By similarity). Plays a role in paternal and maternal imprinting (By similarity). Required for methylation of most imprinted loci in germ cells (By similarity). Acts as a transcriptional corepressor for ZBTB18 (By similarity). Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites (By similarity). Can actively repress transcription through the recruitment of HDAC activity (By similarity). Also has weak auto-methylation activity on Cys-710 in absence of DNA (By similarity). {ECO:0000250|UniProtKB:O88508, ECO:0000269|PubMed:12138111, ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:30478443}. |
| P46782 | RPS5 | S75 | Sugiyama | Small ribosomal subunit protein uS7 (40S ribosomal protein S5) [Cleaved into: Small ribosomal subunit protein uS7, N-terminally processed (40S ribosomal protein S5, N-terminally processed)] | Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| Q99816 | TSG101 | S232 | Sugiyama | Tumor susceptibility gene 101 protein (ESCRT-I complex subunit TSG101) | Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). It may also play a role in the extracellular release of microvesicles that differ from the exosomes (PubMed:22315426). {ECO:0000269|PubMed:11916981, ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:21070952, ECO:0000269|PubMed:21757351, ECO:0000269|PubMed:22315426, ECO:0000269|PubMed:22660413}. |
| Q7Z7G1 | CLNK | S331 | Sugiyama | Cytokine-dependent hematopoietic cell linker (Mast cell immunoreceptor signal transducer) | An adapter protein which plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation (By similarity). Together with FGR, it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production (By similarity). Acts as a positive regulator of both T-cell receptor and natural killer T (NKT) cell receptor signaling in CD4-positive NKT cells (By similarity). Together with MAP4K1, it enhances CD3-triggered activation of T-cells and subsequent IL2 production (By similarity). May be involved in tumor necrosis factor induced cell death by promoting reactive oxidative species generation, and MLKL oligomerization, ultimately leading to necrosis (By similarity). Involved in phosphorylation of LAT (By similarity). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (By similarity). {ECO:0000250|UniProtKB:Q9QZE2}. |
| Q8TDD1 | DDX54 | S587 | Sugiyama | ATP-dependent RNA helicase DDX54 (EC 3.6.4.13) (ATP-dependent RNA helicase DP97) (DEAD box RNA helicase 97 kDa) (DEAD box protein 54) | Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors. {ECO:0000269|PubMed:12466272}. |
| P07384 | CAPN1 | S256 | EPSD|PSP | Calpain-1 catalytic subunit (EC 3.4.22.52) (Calcium-activated neutral proteinase 1) (CANP 1) (Calpain mu-type) (Calpain-1 large subunit) (Cell proliferation-inducing gene 30 protein) (Micromolar-calpain) (muCANP) | Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction (PubMed:19617626, PubMed:21531719, PubMed:2400579). Proteolytically cleaves CTBP1 at 'Asn-375', 'Gly-387' and 'His-409' (PubMed:23707407). Cleaves and activates caspase-7 (CASP7) (PubMed:19617626). {ECO:0000269|PubMed:19617626, ECO:0000269|PubMed:21531719, ECO:0000269|PubMed:23707407, ECO:0000269|PubMed:2400579}. |
| Q9UBQ7 | GRHPR | S260 | Sugiyama | Glyoxylate reductase/hydroxypyruvate reductase (EC 1.1.1.79) (EC 1.1.1.81) | Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate, oxidizes D-glycerate to hydroxypyruvate. {ECO:0000269|PubMed:10484776, ECO:0000269|PubMed:10524214}. |
| P35916 | FLT4 | S1235 | Sugiyama | Vascular endothelial growth factor receptor 3 (VEGFR-3) (EC 2.7.10.1) (Fms-like tyrosine kinase 4) (FLT-4) (Tyrosine-protein kinase receptor FLT4) | Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'. {ECO:0000269|PubMed:11532940, ECO:0000269|PubMed:15102829, ECO:0000269|PubMed:15474514, ECO:0000269|PubMed:16076871, ECO:0000269|PubMed:16452200, ECO:0000269|PubMed:17210781, ECO:0000269|PubMed:19610651, ECO:0000269|PubMed:19779139, ECO:0000269|PubMed:20224550, ECO:0000269|PubMed:20431062, ECO:0000269|PubMed:20445537, ECO:0000269|PubMed:21273538, ECO:0000269|PubMed:7675451, ECO:0000269|PubMed:8700872, ECO:0000269|PubMed:9435229}. |
| Q14974 | KPNB1 | S531 | Sugiyama | Importin subunit beta-1 (Importin-90) (Karyopherin subunit beta-1) (Nuclear factor p97) (Pore targeting complex 97 kDa subunit) (PTAC97) | Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor (PubMed:10228156, PubMed:11682607, PubMed:11891849, PubMed:19386897, PubMed:20818336, PubMed:24699649, PubMed:7615630, PubMed:9687515). Acting autonomously, serves itself as NLS receptor (PubMed:10228156, PubMed:11682607, PubMed:11891849, PubMed:19386897, PubMed:20818336, PubMed:24699649, PubMed:7615630, PubMed:9687515). Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:10228156, PubMed:11682607, PubMed:11891849, PubMed:19386897, PubMed:20818336, PubMed:24699649, PubMed:7615630, PubMed:9687515). At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin (PubMed:10228156, PubMed:11682607, PubMed:11891849, PubMed:19386897, PubMed:20818336, PubMed:24699649, PubMed:7615630, PubMed:9687515). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:10228156, PubMed:11682607, PubMed:11891849, PubMed:19386897, PubMed:24699649, PubMed:7615630, PubMed:9687515). Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5 (PubMed:11682607, PubMed:9687515). In association with IPO7, mediates the nuclear import of H1 histone (PubMed:10228156). In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones (By similarity). Imports MRTFA, SNAI1 and PRKCI into the nucleus (PubMed:11891849, PubMed:19386897, PubMed:20818336, PubMed:24699649). {ECO:0000250|UniProtKB:P70168, ECO:0000269|PubMed:10228156, ECO:0000269|PubMed:11682607, ECO:0000269|PubMed:11891849, ECO:0000269|PubMed:19386897, ECO:0000269|PubMed:20818336, ECO:0000269|PubMed:24699649, ECO:0000269|PubMed:7615630, ECO:0000269|PubMed:9687515}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. {ECO:0000269|PubMed:16704975, ECO:0000269|PubMed:9405152, ECO:0000269|PubMed:9891055}. |
| P42684 | ABL2 | S564 | Sugiyama | Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson tyrosine-protein kinase 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG) | Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 also acts as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). {ECO:0000250|UniProtKB:Q4JIM5, ECO:0000269|PubMed:15735735, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:18945674}. |
| Q9NZV8 | KCND2 | S438 | ELM | A-type voltage-gated potassium channel KCND2 (Potassium voltage-gated channel subfamily D member 2) (Voltage-gated potassium channel subunit Kv4.2) | Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Mediates the major part of the dendritic A-type current I(SA) in brain neurons (By similarity). This current is activated at membrane potentials that are below the threshold for action potentials. It regulates neuronal excitability, prolongs the latency before the first spike in a series of action potentials, regulates the frequency of repetitive action potential firing, shortens the duration of action potentials and regulates the back-propagation of action potentials from the neuronal cell body to the dendrites. Contributes to the regulation of the circadian rhythm of action potential firing in suprachiasmatic nucleus neurons, which regulates the circadian rhythm of locomotor activity (By similarity). Functions downstream of the metabotropic glutamate receptor GRM5 and plays a role in neuronal excitability and in nociception mediated by activation of GRM5 (By similarity). Mediates the transient outward current I(to) in rodent heart left ventricle apex cells, but not in human heart, where this current is mediated by another family member. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient (PubMed:10551270, PubMed:11507158, PubMed:14623880, PubMed:14695263, PubMed:14980201, PubMed:15454437, PubMed:16934482, PubMed:19171772, PubMed:24501278, PubMed:24811166, PubMed:34552243, PubMed:35597238). The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:11507158). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCND2 and KCND3; channel properties depend on the type of pore-forming alpha subunits that are part of the channel. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes. Interaction with specific isoforms of the regulatory subunits KCNIP1, KCNIP2, KCNIP3 or KCNIP4 strongly increases expression at the cell surface and thereby increases channel activity; it modulates the kinetics of channel activation and inactivation, shifts the threshold for channel activation to more negative voltage values, shifts the threshold for inactivation to less negative voltages and accelerates recovery after inactivation (PubMed:14623880, PubMed:14980201, PubMed:15454437, PubMed:19171772, PubMed:24501278, PubMed:24811166). Likewise, interaction with DPP6 or DPP10 promotes expression at the cell membrane and regulates both channel characteristics and activity (By similarity). Upon depolarization, the channel goes from a resting closed state (C state) to an activated but non-conducting state (C* state), from there, the channel may either inactivate (I state) or open (O state) (PubMed:35597238). {ECO:0000250|UniProtKB:Q63881, ECO:0000250|UniProtKB:Q9Z0V2, ECO:0000269|PubMed:10551270, ECO:0000269|PubMed:10729221, ECO:0000269|PubMed:11507158, ECO:0000269|PubMed:14623880, ECO:0000269|PubMed:14695263, ECO:0000269|PubMed:14980201, ECO:0000269|PubMed:15454437, ECO:0000269|PubMed:16934482, ECO:0000269|PubMed:19171772, ECO:0000269|PubMed:24501278, ECO:0000269|PubMed:24811166, ECO:0000269|PubMed:34552243, ECO:0000269|PubMed:35597238}. |
| Q9ULH1 | ASAP1 | Y323 | SIGNOR | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP) | Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:25673879). {ECO:0000250, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:25673879}. |
| Q5S007 | LRRK2 | S1345 | EPSD|PSP | Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin) | Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking (PubMed:17114044, PubMed:20949042, PubMed:21850687, PubMed:22012985, PubMed:23395371, PubMed:24687852, PubMed:25201882, PubMed:26014385, PubMed:26824392, PubMed:27830463, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB29, RAB35, and RAB43 (PubMed:23395371, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421, PubMed:38127736). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PubMed:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (PubMed:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:17114044). Plays a role in synaptic vesicle trafficking (PubMed:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PubMed:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PubMed:22012985). Phosphorylates PRDX3 (PubMed:21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Acts as a positive regulator of innate immunity by mediating phosphorylation of RIPK2 downstream of NOD1 and NOD2, thereby enhancing RIPK2 activation (PubMed:27830463). Independent of its kinase activity, inhibits the proteasomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PubMed:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PubMed:18230735, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29212815). Recruited by RAB29/RAB7L1 to overloaded lysosomes where it phosphorylates and stabilizes RAB8A and RAB10 which promote lysosomal content release and suppress lysosomal enlargement through the EHBP1 and EHBP1L1 effector proteins (PubMed:30209220, PubMed:38227290). {ECO:0000269|PubMed:17114044, ECO:0000269|PubMed:18230735, ECO:0000269|PubMed:20949042, ECO:0000269|PubMed:21850687, ECO:0000269|PubMed:22012985, ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:24687852, ECO:0000269|PubMed:25201882, ECO:0000269|PubMed:26014385, ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:27830463, ECO:0000269|PubMed:28720718, ECO:0000269|PubMed:29125462, ECO:0000269|PubMed:29127255, ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:30209220, ECO:0000269|PubMed:30398148, ECO:0000269|PubMed:30635421, ECO:0000269|PubMed:38127736, ECO:0000269|PubMed:38227290}. |
| Q14683 | SMC1A | S649 | Sugiyama | Structural maintenance of chromosomes protein 1A (SMC protein 1A) (SMC-1-alpha) (SMC-1A) (Sb1.8) | Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint. {ECO:0000269|PubMed:11877377}. |
| Q16762 | TST | S35 | Sugiyama | Thiosulfate sulfurtransferase (EC 2.8.1.1) (Rhodanese) | Formation of iron-sulfur complexes, cyanide detoxification or modification of sulfur-containing enzymes. Other thiol compounds, besides cyanide, can act as sulfur ion acceptors. Also has weak mercaptopyruvate sulfurtransferase (MST) activity (By similarity). Together with MRPL18, acts as a mitochondrial import factor for the cytosolic 5S rRNA. Only the nascent unfolded cytoplasmic form is able to bind to the 5S rRNA. {ECO:0000250, ECO:0000269|PubMed:20663881, ECO:0000269|PubMed:21685364}. |
| Q5T5U3 | ARHGAP21 | S1553 | Sugiyama | Rho GTPase-activating protein 21 (Rho GTPase-activating protein 10) (Rho-type GTPase-activating protein 21) | Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions. {ECO:0000269|PubMed:15793564, ECO:0000269|PubMed:16184169}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.000021 | 4.668 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.000623 | 3.205 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.000707 | 3.151 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.000750 | 3.125 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 0.001520 | 2.818 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 0.001520 | 2.818 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.001581 | 2.801 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.001869 | 2.728 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.002784 | 2.555 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.004931 | 2.307 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 0.005251 | 2.280 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 0.007180 | 2.144 |
| R-HSA-157118 | Signaling by NOTCH | 0.006095 | 2.215 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 0.006506 | 2.187 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.006703 | 2.174 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 0.007884 | 2.103 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 0.009380 | 2.028 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.009226 | 2.035 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.009380 | 2.028 |
| R-HSA-6798695 | Neutrophil degranulation | 0.010598 | 1.975 |
| R-HSA-162582 | Signal Transduction | 0.011215 | 1.950 |
| R-HSA-176034 | Interactions of Tat with host cellular proteins | 0.018642 | 1.730 |
| R-HSA-8853336 | Signaling by plasma membrane FGFR1 fusions | 0.030879 | 1.510 |
| R-HSA-1251932 | PLCG1 events in ERBB2 signaling | 0.036940 | 1.433 |
| R-HSA-9818035 | NFE2L2 regulating ER-stress associated genes | 0.036940 | 1.433 |
| R-HSA-9818026 | NFE2L2 regulating inflammation associated genes | 0.042964 | 1.367 |
| R-HSA-5638302 | Signaling by Overexpressed Wild-Type EGFR in Cancer | 0.048951 | 1.310 |
| R-HSA-5638303 | Inhibition of Signaling by Overexpressed EGFR | 0.048951 | 1.310 |
| R-HSA-5576894 | Phase 1 - inactivation of fast Na+ channels | 0.048951 | 1.310 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 0.060813 | 1.216 |
| R-HSA-212718 | EGFR interacts with phospholipase C-gamma | 0.066689 | 1.176 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 0.072529 | 1.139 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 0.078332 | 1.106 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.095528 | 1.020 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.020693 | 1.684 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 0.106815 | 0.971 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 0.112406 | 0.949 |
| R-HSA-73780 | RNA Polymerase III Chain Elongation | 0.112406 | 0.949 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 0.112406 | 0.949 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.030245 | 1.519 |
| R-HSA-429947 | Deadenylation of mRNA | 0.171666 | 0.765 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.056641 | 1.247 |
| R-HSA-72649 | Translation initiation complex formation | 0.058282 | 1.234 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.061611 | 1.210 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.065003 | 1.187 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.187137 | 0.728 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.187137 | 0.728 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.192230 | 0.716 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.192230 | 0.716 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.039411 | 1.404 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.040235 | 1.395 |
| R-HSA-390522 | Striated Muscle Contraction | 0.222131 | 0.653 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 0.227007 | 0.644 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.120143 | 0.920 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.130550 | 0.884 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.132656 | 0.877 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.141157 | 0.850 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.143301 | 0.844 |
| R-HSA-192823 | Viral mRNA Translation | 0.160686 | 0.794 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.182012 | 0.740 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.150585 | 0.822 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.150585 | 0.822 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.128972 | 0.890 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.128972 | 0.890 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 0.095528 | 1.020 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.134426 | 0.872 |
| R-HSA-182971 | EGFR downregulation | 0.207320 | 0.683 |
| R-HSA-1170546 | Prolactin receptor signaling | 0.106815 | 0.971 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.227007 | 0.644 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.021805 | 1.661 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.182921 | 0.738 |
| R-HSA-180292 | GAB1 signalosome | 0.134426 | 0.872 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 0.145232 | 0.838 |
| R-HSA-156902 | Peptide chain elongation | 0.124280 | 0.906 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.182921 | 0.738 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.021805 | 1.661 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.048951 | 1.310 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.171666 | 0.765 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.197291 | 0.705 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.048951 | 1.310 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 0.095528 | 1.020 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.187137 | 0.728 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.030245 | 1.519 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.095528 | 1.020 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.034198 | 1.466 |
| R-HSA-179812 | GRB2 events in EGFR signaling | 0.095528 | 1.020 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.202321 | 0.694 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.040235 | 1.395 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.207860 | 0.682 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.207860 | 0.682 |
| R-HSA-9636249 | Inhibition of nitric oxide production | 0.030879 | 1.510 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.025283 | 1.597 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.143301 | 0.844 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.202321 | 0.694 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 0.089832 | 1.047 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.222131 | 0.653 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 0.078332 | 1.106 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 0.089832 | 1.047 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.089832 | 1.047 |
| R-HSA-174490 | Membrane binding and targetting of GAG proteins | 0.101189 | 0.995 |
| R-HSA-162588 | Budding and maturation of HIV virion | 0.022940 | 1.639 |
| R-HSA-9603798 | Class I peroxisomal membrane protein import | 0.117962 | 0.928 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 0.123484 | 0.908 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.014238 | 1.847 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 0.155904 | 0.807 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 0.161191 | 0.793 |
| R-HSA-9865881 | Complex III assembly | 0.171666 | 0.765 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.066723 | 1.176 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 0.197291 | 0.705 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.222131 | 0.653 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 0.236668 | 0.626 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.202321 | 0.694 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.090690 | 1.042 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 0.095528 | 1.020 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.134770 | 0.870 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.122508 | 0.912 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 0.128972 | 0.890 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.088466 | 1.053 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.103967 | 0.983 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 0.066689 | 1.176 |
| R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 0.106815 | 0.971 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 0.161191 | 0.793 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.165093 | 0.782 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.165093 | 0.782 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.217225 | 0.663 |
| R-HSA-205025 | NADE modulates death signalling | 0.036940 | 1.433 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 0.048951 | 1.310 |
| R-HSA-195399 | VEGF binds to VEGFR leading to receptor dimerization | 0.048951 | 1.310 |
| R-HSA-1433617 | Regulation of signaling by NODAL | 0.072529 | 1.139 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.134426 | 0.872 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 0.139845 | 0.854 |
| R-HSA-429958 | mRNA decay by 3' to 5' exoribonuclease | 0.139845 | 0.854 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 0.176855 | 0.752 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.197291 | 0.705 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.217225 | 0.663 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.040235 | 1.395 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.222131 | 0.653 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 0.227007 | 0.644 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.016065 | 1.794 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.080031 | 1.097 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.147609 | 0.831 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 0.054900 | 1.260 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.145232 | 0.838 |
| R-HSA-5334118 | DNA methylation | 0.197291 | 0.705 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.156303 | 0.806 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.123484 | 0.908 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 0.217225 | 0.663 |
| R-HSA-194313 | VEGF ligand-receptor interactions | 0.048951 | 1.310 |
| R-HSA-8948747 | Regulation of PTEN localization | 0.060813 | 1.216 |
| R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 0.072529 | 1.139 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 0.078332 | 1.106 |
| R-HSA-9839394 | TGFBR3 expression | 0.016498 | 1.783 |
| R-HSA-6811555 | PI5P Regulates TP53 Acetylation | 0.101189 | 0.995 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.117962 | 0.928 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.161191 | 0.793 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.162887 | 0.788 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 0.095528 | 1.020 |
| R-HSA-9762293 | Regulation of CDH11 gene transcription | 0.072529 | 1.139 |
| R-HSA-8939211 | ESR-mediated signaling | 0.023274 | 1.633 |
| R-HSA-162587 | HIV Life Cycle | 0.098109 | 1.008 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.042964 | 1.367 |
| R-HSA-9733458 | Induction of Cell-Cell Fusion | 0.117962 | 0.928 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.134426 | 0.872 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.182012 | 0.740 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.101990 | 0.991 |
| R-HSA-162906 | HIV Infection | 0.070490 | 1.152 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.015689 | 1.804 |
| R-HSA-68882 | Mitotic Anaphase | 0.185239 | 0.732 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.154120 | 0.812 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 0.123484 | 0.908 |
| R-HSA-1369062 | ABC transporters in lipid homeostasis | 0.166445 | 0.779 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.171666 | 0.765 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.186810 | 0.729 |
| R-HSA-9637687 | Suppression of phagosomal maturation | 0.182012 | 0.740 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.212435 | 0.673 |
| R-HSA-611105 | Respiratory electron transport | 0.127274 | 0.895 |
| R-HSA-1614517 | Sulfide oxidation to sulfate | 0.128972 | 0.890 |
| R-HSA-1181150 | Signaling by NODAL | 0.145232 | 0.838 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.182012 | 0.740 |
| R-HSA-9707616 | Heme signaling | 0.071971 | 1.143 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.176855 | 0.752 |
| R-HSA-8848021 | Signaling by PTK6 | 0.073749 | 1.132 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.073749 | 1.132 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.015197 | 1.818 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.214726 | 0.668 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 0.072529 | 1.139 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 0.078332 | 1.106 |
| R-HSA-9856872 | Malate-aspartate shuttle | 0.106815 | 0.971 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.155904 | 0.807 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.161191 | 0.793 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.061611 | 1.210 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 0.207320 | 0.683 |
| R-HSA-2262752 | Cellular responses to stress | 0.204393 | 0.690 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.171666 | 0.765 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.171666 | 0.765 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 0.161191 | 0.793 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.093720 | 1.028 |
| R-HSA-175474 | Assembly Of The HIV Virion | 0.155904 | 0.807 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.187137 | 0.728 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.195517 | 0.709 |
| R-HSA-168255 | Influenza Infection | 0.128668 | 0.891 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 0.117962 | 0.928 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 0.150585 | 0.822 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.014713 | 1.832 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.207965 | 0.682 |
| R-HSA-397014 | Muscle contraction | 0.178992 | 0.747 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 0.222131 | 0.653 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.124280 | 0.906 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.197291 | 0.705 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.231852 | 0.635 |
| R-HSA-69275 | G2/M Transition | 0.138574 | 0.858 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.051624 | 1.287 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.141451 | 0.849 |
| R-HSA-1640170 | Cell Cycle | 0.173932 | 0.760 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.026179 | 1.582 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.040235 | 1.395 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 0.112406 | 0.949 |
| R-HSA-445144 | Signal transduction by L1 | 0.145232 | 0.838 |
| R-HSA-8963693 | Aspartate and asparagine metabolism | 0.207320 | 0.683 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.217225 | 0.663 |
| R-HSA-1980145 | Signaling by NOTCH2 | 0.227007 | 0.644 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.076453 | 1.117 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.045643 | 1.341 |
| R-HSA-111933 | Calmodulin induced events | 0.236668 | 0.626 |
| R-HSA-9706369 | Negative regulation of FLT3 | 0.117962 | 0.928 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.166445 | 0.779 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.207320 | 0.683 |
| R-HSA-111997 | CaM pathway | 0.236668 | 0.626 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.217225 | 0.663 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.192994 | 0.714 |
| R-HSA-73943 | Reversal of alkylation damage by DNA dioxygenases | 0.095528 | 1.020 |
| R-HSA-1538133 | G0 and Early G1 | 0.024100 | 1.618 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.212288 | 0.673 |
| R-HSA-9824446 | Viral Infection Pathways | 0.105329 | 0.977 |
| R-HSA-75153 | Apoptotic execution phase | 0.045643 | 1.341 |
| R-HSA-73942 | DNA Damage Reversal | 0.112406 | 0.949 |
| R-HSA-5576891 | Cardiac conduction | 0.235443 | 0.628 |
| R-HSA-983712 | Ion channel transport | 0.142897 | 0.845 |
| R-HSA-194138 | Signaling by VEGF | 0.219316 | 0.659 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.094193 | 1.026 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.182012 | 0.740 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.227007 | 0.644 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.094369 | 1.025 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.032392 | 1.490 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.086581 | 1.063 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.166445 | 0.779 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.214020 | 0.670 |
| R-HSA-168249 | Innate Immune System | 0.139066 | 0.857 |
| R-HSA-422475 | Axon guidance | 0.145530 | 0.837 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.073253 | 1.135 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.217225 | 0.663 |
| R-HSA-9675108 | Nervous system development | 0.178345 | 0.749 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.212288 | 0.673 |
| R-HSA-9828806 | Maturation of hRSV A proteins | 0.187137 | 0.728 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.120143 | 0.920 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.034284 | 1.465 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.132656 | 0.877 |
| R-HSA-73887 | Death Receptor Signaling | 0.094369 | 1.025 |
| R-HSA-9679506 | SARS-CoV Infections | 0.154105 | 0.812 |
| R-HSA-9909396 | Circadian clock | 0.237754 | 0.624 |
| R-HSA-4839726 | Chromatin organization | 0.238698 | 0.622 |
| R-HSA-1296072 | Voltage gated Potassium channels | 0.241453 | 0.617 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.241453 | 0.617 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 0.246209 | 0.609 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.248407 | 0.605 |
| R-HSA-913531 | Interferon Signaling | 0.248407 | 0.605 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.250936 | 0.600 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.250936 | 0.600 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.250936 | 0.600 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.250936 | 0.600 |
| R-HSA-201556 | Signaling by ALK | 0.250936 | 0.600 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 0.250936 | 0.600 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.253955 | 0.595 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.255633 | 0.592 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.255633 | 0.592 |
| R-HSA-167169 | HIV Transcription Elongation | 0.255633 | 0.592 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.255633 | 0.592 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.255633 | 0.592 |
| R-HSA-3371568 | Attenuation phase | 0.255633 | 0.592 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.255633 | 0.592 |
| R-HSA-6807070 | PTEN Regulation | 0.256273 | 0.591 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.256273 | 0.591 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.260301 | 0.585 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.260301 | 0.585 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 0.260301 | 0.585 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.260301 | 0.585 |
| R-HSA-9607240 | FLT3 Signaling | 0.260301 | 0.585 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.262154 | 0.581 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.264940 | 0.577 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.269550 | 0.569 |
| R-HSA-111996 | Ca-dependent events | 0.269550 | 0.569 |
| R-HSA-165159 | MTOR signalling | 0.269550 | 0.569 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.270607 | 0.568 |
| R-HSA-9710421 | Defective pyroptosis | 0.274131 | 0.562 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 0.274131 | 0.562 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.274131 | 0.562 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.274822 | 0.561 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.278684 | 0.555 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.283209 | 0.548 |
| R-HSA-774815 | Nucleosome assembly | 0.283209 | 0.548 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.283209 | 0.548 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.283209 | 0.548 |
| R-HSA-1614558 | Degradation of cysteine and homocysteine | 0.283209 | 0.548 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.287705 | 0.541 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.288726 | 0.540 |
| R-HSA-9609507 | Protein localization | 0.291041 | 0.536 |
| R-HSA-168256 | Immune System | 0.294098 | 0.532 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.295669 | 0.529 |
| R-HSA-1989781 | PPARA activates gene expression | 0.295669 | 0.529 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.296615 | 0.528 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.300292 | 0.522 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.301028 | 0.521 |
| R-HSA-389661 | Glyoxylate metabolism and glycine degradation | 0.301028 | 0.521 |
| R-HSA-9711097 | Cellular response to starvation | 0.302602 | 0.519 |
| R-HSA-9748787 | Azathioprine ADME | 0.305414 | 0.515 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.309773 | 0.509 |
| R-HSA-9864848 | Complex IV assembly | 0.309773 | 0.509 |
| R-HSA-109581 | Apoptosis | 0.311830 | 0.506 |
| R-HSA-72766 | Translation | 0.312482 | 0.505 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.314105 | 0.503 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.314105 | 0.503 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.314105 | 0.503 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.314105 | 0.503 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.316434 | 0.500 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.316434 | 0.500 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.316678 | 0.499 |
| R-HSA-1221632 | Meiotic synapsis | 0.318409 | 0.497 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.318409 | 0.497 |
| R-HSA-8956320 | Nucleotide biosynthesis | 0.318409 | 0.497 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.318409 | 0.497 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.322687 | 0.491 |
| R-HSA-418597 | G alpha (z) signalling events | 0.326939 | 0.486 |
| R-HSA-177929 | Signaling by EGFR | 0.331164 | 0.480 |
| R-HSA-5578775 | Ion homeostasis | 0.331164 | 0.480 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.332495 | 0.478 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.334781 | 0.475 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.335362 | 0.474 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.337066 | 0.472 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.339535 | 0.469 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.339535 | 0.469 |
| R-HSA-4085001 | Sialic acid metabolism | 0.343681 | 0.464 |
| R-HSA-186712 | Regulation of beta-cell development | 0.343681 | 0.464 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.347802 | 0.459 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.347802 | 0.459 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.347802 | 0.459 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.347802 | 0.459 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.347802 | 0.459 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.347802 | 0.459 |
| R-HSA-983189 | Kinesins | 0.347802 | 0.459 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.347802 | 0.459 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.351897 | 0.454 |
| R-HSA-112043 | PLC beta mediated events | 0.351897 | 0.454 |
| R-HSA-2559583 | Cellular Senescence | 0.355253 | 0.449 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.355967 | 0.449 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.355967 | 0.449 |
| R-HSA-1268020 | Mitochondrial protein import | 0.355967 | 0.449 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.360012 | 0.444 |
| R-HSA-373755 | Semaphorin interactions | 0.360012 | 0.444 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.364031 | 0.439 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.364642 | 0.438 |
| R-HSA-74160 | Gene expression (Transcription) | 0.366145 | 0.436 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.368025 | 0.434 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.371995 | 0.429 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.372709 | 0.429 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.373267 | 0.428 |
| R-HSA-112040 | G-protein mediated events | 0.375940 | 0.425 |
| R-HSA-167172 | Transcription of the HIV genome | 0.379860 | 0.420 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.379860 | 0.420 |
| R-HSA-68877 | Mitotic Prometaphase | 0.384426 | 0.415 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.387627 | 0.412 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.391475 | 0.407 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.391475 | 0.407 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.391475 | 0.407 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.395248 | 0.403 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.395299 | 0.403 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.395299 | 0.403 |
| R-HSA-212436 | Generic Transcription Pathway | 0.399212 | 0.399 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.399906 | 0.398 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.402875 | 0.395 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.402875 | 0.395 |
| R-HSA-917937 | Iron uptake and transport | 0.406627 | 0.391 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.406627 | 0.391 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.410357 | 0.387 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.410357 | 0.387 |
| R-HSA-5357801 | Programmed Cell Death | 0.413032 | 0.384 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.414063 | 0.383 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.417746 | 0.379 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.417746 | 0.379 |
| R-HSA-5619084 | ABC transporter disorders | 0.417746 | 0.379 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.425043 | 0.372 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.425043 | 0.372 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.425043 | 0.372 |
| R-HSA-977225 | Amyloid fiber formation | 0.428658 | 0.368 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.428658 | 0.368 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.432250 | 0.364 |
| R-HSA-1500620 | Meiosis | 0.442893 | 0.354 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.446397 | 0.350 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.446397 | 0.350 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.446397 | 0.350 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.446397 | 0.350 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 0.449879 | 0.347 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.453339 | 0.344 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.457821 | 0.339 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 0.463590 | 0.334 |
| R-HSA-68886 | M Phase | 0.464967 | 0.333 |
| R-HSA-1266738 | Developmental Biology | 0.465736 | 0.332 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.466965 | 0.331 |
| R-HSA-72312 | rRNA processing | 0.470261 | 0.328 |
| R-HSA-391251 | Protein folding | 0.473651 | 0.325 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.473651 | 0.325 |
| R-HSA-372790 | Signaling by GPCR | 0.474693 | 0.324 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.476963 | 0.322 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.480255 | 0.319 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.480255 | 0.319 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.483526 | 0.316 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.486776 | 0.313 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.490006 | 0.310 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.490006 | 0.310 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.490006 | 0.310 |
| R-HSA-1296071 | Potassium Channels | 0.490006 | 0.310 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.499577 | 0.301 |
| R-HSA-3214847 | HATs acetylate histones | 0.499577 | 0.301 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.502727 | 0.299 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.505858 | 0.296 |
| R-HSA-9609646 | HCMV Infection | 0.506551 | 0.295 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.508969 | 0.293 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.508969 | 0.293 |
| R-HSA-1483255 | PI Metabolism | 0.508969 | 0.293 |
| R-HSA-5663205 | Infectious disease | 0.513544 | 0.289 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.515134 | 0.288 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.515134 | 0.288 |
| R-HSA-111885 | Opioid Signalling | 0.515134 | 0.288 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.515971 | 0.287 |
| R-HSA-9833110 | RSV-host interactions | 0.518187 | 0.286 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.518290 | 0.285 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.533171 | 0.273 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.533171 | 0.273 |
| R-HSA-416476 | G alpha (q) signalling events | 0.533657 | 0.273 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.544825 | 0.264 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.547694 | 0.261 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.553377 | 0.257 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.556192 | 0.255 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 0.556192 | 0.255 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.556192 | 0.255 |
| R-HSA-373760 | L1CAM interactions | 0.558989 | 0.253 |
| R-HSA-388396 | GPCR downstream signalling | 0.561511 | 0.251 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.561769 | 0.250 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.561769 | 0.250 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.564531 | 0.248 |
| R-HSA-73886 | Chromosome Maintenance | 0.572716 | 0.242 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 0.572716 | 0.242 |
| R-HSA-3371556 | Cellular response to heat stress | 0.572716 | 0.242 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.578087 | 0.238 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.580748 | 0.236 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.586020 | 0.232 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.586020 | 0.232 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.586020 | 0.232 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.591076 | 0.228 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.593804 | 0.226 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.598913 | 0.223 |
| R-HSA-1474165 | Reproduction | 0.601444 | 0.221 |
| R-HSA-9843745 | Adipogenesis | 0.603958 | 0.219 |
| R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 0.603958 | 0.219 |
| R-HSA-382551 | Transport of small molecules | 0.605209 | 0.218 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.606458 | 0.217 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.606458 | 0.217 |
| R-HSA-199991 | Membrane Trafficking | 0.608577 | 0.216 |
| R-HSA-8953854 | Metabolism of RNA | 0.627746 | 0.202 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.631731 | 0.199 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.637559 | 0.195 |
| R-HSA-8957322 | Metabolism of steroids | 0.638093 | 0.195 |
| R-HSA-69242 | S Phase | 0.648862 | 0.188 |
| R-HSA-166520 | Signaling by NTRKs | 0.648862 | 0.188 |
| R-HSA-9758941 | Gastrulation | 0.651080 | 0.186 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.653285 | 0.185 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.657362 | 0.182 |
| R-HSA-69306 | DNA Replication | 0.659816 | 0.181 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.661966 | 0.179 |
| R-HSA-9612973 | Autophagy | 0.666225 | 0.176 |
| R-HSA-1280218 | Adaptive Immune System | 0.666367 | 0.176 |
| R-HSA-9610379 | HCMV Late Events | 0.668335 | 0.175 |
| R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 0.668335 | 0.175 |
| R-HSA-877300 | Interferon gamma signaling | 0.672515 | 0.172 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.674585 | 0.171 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.675937 | 0.170 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.690850 | 0.161 |
| R-HSA-418555 | G alpha (s) signalling events | 0.698441 | 0.156 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.702245 | 0.154 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.702245 | 0.154 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.704129 | 0.152 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.706002 | 0.151 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.720564 | 0.142 |
| R-HSA-5617833 | Cilium Assembly | 0.732719 | 0.135 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.734412 | 0.134 |
| R-HSA-9609690 | HCMV Early Events | 0.742720 | 0.129 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.742720 | 0.129 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.749180 | 0.125 |
| R-HSA-6805567 | Keratinization | 0.760102 | 0.119 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.769372 | 0.114 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.770552 | 0.113 |
| R-HSA-392499 | Metabolism of proteins | 0.772838 | 0.112 |
| R-HSA-418990 | Adherens junctions interactions | 0.777740 | 0.109 |
| R-HSA-9748784 | Drug ADME | 0.777740 | 0.109 |
| R-HSA-8951664 | Neddylation | 0.781945 | 0.107 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.791453 | 0.102 |
| R-HSA-15869 | Metabolism of nucleotides | 0.801817 | 0.096 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.815240 | 0.089 |
| R-HSA-421270 | Cell-cell junction organization | 0.819894 | 0.086 |
| R-HSA-5688426 | Deubiquitination | 0.824433 | 0.084 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.827762 | 0.082 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.844490 | 0.073 |
| R-HSA-446728 | Cell junction organization | 0.848414 | 0.071 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.849380 | 0.071 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.858707 | 0.066 |
| R-HSA-1483257 | Phospholipid metabolism | 0.864027 | 0.063 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.864894 | 0.063 |
| R-HSA-195721 | Signaling by WNT | 0.866612 | 0.062 |
| R-HSA-1643685 | Disease | 0.876572 | 0.057 |
| R-HSA-1500931 | Cell-Cell communication | 0.881131 | 0.055 |
| R-HSA-1474244 | Extracellular matrix organization | 0.892026 | 0.050 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.902559 | 0.045 |
| R-HSA-73894 | DNA Repair | 0.910362 | 0.041 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.926562 | 0.033 |
| R-HSA-418594 | G alpha (i) signalling events | 0.934177 | 0.030 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.940244 | 0.027 |
| R-HSA-112316 | Neuronal System | 0.955604 | 0.020 |
| R-HSA-597592 | Post-translational protein modification | 0.958946 | 0.018 |
| R-HSA-109582 | Hemostasis | 0.964447 | 0.016 |
| R-HSA-500792 | GPCR ligand binding | 0.979765 | 0.009 |
| R-HSA-556833 | Metabolism of lipids | 0.987939 | 0.005 |
| R-HSA-1430728 | Metabolism | 0.998866 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.851 | 0.214 | 2 | 0.869 |
PIM3 |
0.843 | 0.249 | -3 | 0.797 |
PRKD1 |
0.839 | 0.153 | -3 | 0.808 |
NEK6 |
0.834 | 0.138 | -2 | 0.846 |
NDR2 |
0.834 | 0.092 | -3 | 0.809 |
ULK2 |
0.834 | 0.018 | 2 | 0.790 |
TBK1 |
0.833 | -0.007 | 1 | 0.652 |
MST4 |
0.832 | 0.107 | 2 | 0.834 |
IKKB |
0.832 | -0.010 | -2 | 0.711 |
PIM1 |
0.831 | 0.221 | -3 | 0.754 |
DSTYK |
0.831 | 0.094 | 2 | 0.845 |
PRKD2 |
0.831 | 0.111 | -3 | 0.768 |
NDR1 |
0.830 | 0.086 | -3 | 0.806 |
MTOR |
0.829 | -0.013 | 1 | 0.649 |
IKKE |
0.829 | -0.028 | 1 | 0.638 |
RAF1 |
0.829 | -0.033 | 1 | 0.686 |
NEK7 |
0.827 | 0.027 | -3 | 0.787 |
CDC7 |
0.827 | -0.034 | 1 | 0.612 |
MOS |
0.827 | 0.056 | 1 | 0.676 |
ERK5 |
0.827 | 0.088 | 1 | 0.687 |
CLK3 |
0.826 | 0.092 | 1 | 0.604 |
PRPK |
0.826 | -0.070 | -1 | 0.792 |
PKCD |
0.826 | 0.094 | 2 | 0.790 |
CDKL1 |
0.825 | 0.076 | -3 | 0.768 |
CDKL5 |
0.825 | 0.095 | -3 | 0.768 |
IKKA |
0.825 | 0.050 | -2 | 0.701 |
PKN3 |
0.825 | 0.025 | -3 | 0.801 |
NLK |
0.824 | 0.009 | 1 | 0.649 |
AURC |
0.824 | 0.108 | -2 | 0.639 |
GCN2 |
0.824 | -0.071 | 2 | 0.773 |
CAMK1B |
0.824 | 0.011 | -3 | 0.821 |
AMPKA1 |
0.823 | 0.055 | -3 | 0.826 |
PDHK4 |
0.823 | -0.170 | 1 | 0.690 |
SRPK1 |
0.822 | 0.084 | -3 | 0.723 |
PDHK1 |
0.822 | -0.110 | 1 | 0.690 |
BMPR2 |
0.822 | 0.030 | -2 | 0.846 |
LATS2 |
0.822 | 0.041 | -5 | 0.796 |
TGFBR2 |
0.822 | 0.066 | -2 | 0.787 |
MARK4 |
0.821 | 0.028 | 4 | 0.771 |
RSK2 |
0.821 | 0.056 | -3 | 0.748 |
PKN2 |
0.821 | 0.013 | -3 | 0.807 |
RSK3 |
0.820 | 0.053 | -3 | 0.735 |
PKACG |
0.820 | 0.053 | -2 | 0.711 |
NIK |
0.820 | 0.021 | -3 | 0.838 |
NIM1 |
0.820 | 0.056 | 3 | 0.787 |
SKMLCK |
0.820 | 0.053 | -2 | 0.786 |
WNK1 |
0.819 | -0.017 | -2 | 0.781 |
NUAK2 |
0.819 | 0.040 | -3 | 0.803 |
ULK1 |
0.819 | -0.090 | -3 | 0.785 |
NEK9 |
0.819 | 0.003 | 2 | 0.827 |
BCKDK |
0.818 | -0.062 | -1 | 0.806 |
CAMK2G |
0.818 | -0.063 | 2 | 0.790 |
PAK1 |
0.818 | 0.053 | -2 | 0.741 |
AMPKA2 |
0.818 | 0.045 | -3 | 0.800 |
RIPK3 |
0.818 | -0.044 | 3 | 0.748 |
TSSK1 |
0.818 | 0.057 | -3 | 0.847 |
MNK2 |
0.818 | 0.053 | -2 | 0.751 |
ATR |
0.818 | -0.071 | 1 | 0.617 |
ICK |
0.817 | 0.059 | -3 | 0.804 |
CHAK2 |
0.817 | 0.004 | -1 | 0.812 |
PAK3 |
0.817 | 0.022 | -2 | 0.744 |
P90RSK |
0.816 | 0.027 | -3 | 0.751 |
CAMLCK |
0.816 | 0.013 | -2 | 0.807 |
P70S6KB |
0.815 | 0.030 | -3 | 0.772 |
HUNK |
0.815 | -0.064 | 2 | 0.793 |
KIS |
0.815 | 0.015 | 1 | 0.535 |
MAPKAPK3 |
0.814 | -0.009 | -3 | 0.770 |
PKCA |
0.814 | 0.072 | 2 | 0.721 |
MLK2 |
0.814 | 0.010 | 2 | 0.815 |
MASTL |
0.814 | -0.029 | -2 | 0.768 |
SRPK2 |
0.814 | 0.069 | -3 | 0.652 |
HIPK4 |
0.814 | -0.001 | 1 | 0.572 |
PKCB |
0.814 | 0.055 | 2 | 0.727 |
TSSK2 |
0.814 | 0.007 | -5 | 0.874 |
PKACB |
0.814 | 0.090 | -2 | 0.658 |
FAM20C |
0.813 | 0.056 | 2 | 0.539 |
DAPK2 |
0.813 | 0.007 | -3 | 0.828 |
PLK4 |
0.813 | 0.084 | 2 | 0.620 |
IRE1 |
0.813 | 0.006 | 1 | 0.653 |
WNK3 |
0.813 | -0.148 | 1 | 0.677 |
PKCG |
0.813 | 0.044 | 2 | 0.728 |
MLK1 |
0.813 | -0.078 | 2 | 0.787 |
PKCZ |
0.813 | 0.063 | 2 | 0.771 |
PAK6 |
0.812 | 0.042 | -2 | 0.688 |
CAMK2D |
0.812 | -0.039 | -3 | 0.821 |
ANKRD3 |
0.812 | 0.007 | 1 | 0.698 |
PRKD3 |
0.812 | 0.042 | -3 | 0.720 |
AURB |
0.812 | 0.064 | -2 | 0.638 |
MELK |
0.812 | 0.016 | -3 | 0.792 |
PLK1 |
0.811 | 0.075 | -2 | 0.843 |
MAPKAPK2 |
0.811 | 0.027 | -3 | 0.721 |
PIM2 |
0.811 | 0.165 | -3 | 0.726 |
CDK8 |
0.811 | -0.023 | 1 | 0.513 |
LATS1 |
0.811 | 0.084 | -3 | 0.821 |
NEK2 |
0.810 | -0.008 | 2 | 0.798 |
QSK |
0.810 | 0.035 | 4 | 0.756 |
NUAK1 |
0.810 | 0.013 | -3 | 0.769 |
CDK5 |
0.810 | 0.054 | 1 | 0.542 |
MPSK1 |
0.810 | 0.365 | 1 | 0.805 |
GRK5 |
0.809 | -0.142 | -3 | 0.787 |
IRE2 |
0.808 | 0.021 | 2 | 0.744 |
PKR |
0.808 | 0.065 | 1 | 0.677 |
CDK19 |
0.808 | -0.014 | 1 | 0.488 |
MNK1 |
0.808 | 0.028 | -2 | 0.770 |
CDK7 |
0.807 | -0.016 | 1 | 0.524 |
SGK3 |
0.807 | 0.061 | -3 | 0.744 |
SRPK3 |
0.807 | 0.065 | -3 | 0.686 |
MSK2 |
0.807 | -0.002 | -3 | 0.712 |
PKG2 |
0.807 | 0.047 | -2 | 0.662 |
CAMK4 |
0.807 | -0.053 | -3 | 0.788 |
YSK4 |
0.807 | -0.020 | 1 | 0.664 |
CDK18 |
0.807 | 0.030 | 1 | 0.477 |
AKT2 |
0.806 | 0.072 | -3 | 0.669 |
SIK |
0.806 | 0.013 | -3 | 0.736 |
PRKX |
0.806 | 0.098 | -3 | 0.659 |
MLK3 |
0.806 | -0.015 | 2 | 0.727 |
RIPK1 |
0.806 | -0.139 | 1 | 0.652 |
PAK2 |
0.806 | -0.004 | -2 | 0.732 |
QIK |
0.805 | -0.047 | -3 | 0.798 |
CHK1 |
0.805 | 0.041 | -3 | 0.799 |
PHKG1 |
0.805 | -0.036 | -3 | 0.800 |
PKCH |
0.804 | 0.001 | 2 | 0.708 |
DLK |
0.804 | -0.193 | 1 | 0.643 |
PBK |
0.803 | 0.530 | 1 | 0.897 |
TTBK2 |
0.803 | -0.127 | 2 | 0.719 |
GRK6 |
0.803 | -0.093 | 1 | 0.610 |
GRK1 |
0.803 | -0.062 | -2 | 0.720 |
RSK4 |
0.803 | 0.037 | -3 | 0.716 |
JNK2 |
0.803 | 0.011 | 1 | 0.468 |
CAMK2B |
0.802 | -0.015 | 2 | 0.750 |
P38A |
0.802 | 0.020 | 1 | 0.577 |
CDK13 |
0.801 | -0.025 | 1 | 0.502 |
PKCT |
0.801 | 0.032 | 2 | 0.727 |
IRAK4 |
0.801 | 0.033 | 1 | 0.666 |
DCAMKL1 |
0.801 | 0.036 | -3 | 0.762 |
AKT1 |
0.801 | 0.071 | -3 | 0.693 |
HRI |
0.801 | 0.064 | -2 | 0.847 |
GRK7 |
0.801 | 0.050 | 1 | 0.576 |
DYRK2 |
0.801 | -0.021 | 1 | 0.506 |
NEK5 |
0.800 | 0.096 | 1 | 0.708 |
JNK3 |
0.800 | -0.004 | 1 | 0.492 |
PKACA |
0.800 | 0.069 | -2 | 0.616 |
MSK1 |
0.799 | 0.009 | -3 | 0.723 |
CHAK1 |
0.799 | -0.089 | 2 | 0.790 |
MARK2 |
0.799 | -0.018 | 4 | 0.671 |
ALK4 |
0.799 | -0.057 | -2 | 0.753 |
GRK4 |
0.799 | -0.133 | -2 | 0.779 |
TGFBR1 |
0.799 | -0.028 | -2 | 0.719 |
PAK5 |
0.798 | 0.019 | -2 | 0.643 |
AURA |
0.798 | 0.014 | -2 | 0.610 |
VRK2 |
0.798 | -0.091 | 1 | 0.691 |
BRSK2 |
0.798 | -0.069 | -3 | 0.800 |
GAK |
0.798 | 0.481 | 1 | 0.857 |
MEK1 |
0.798 | -0.120 | 2 | 0.830 |
ATM |
0.798 | -0.090 | 1 | 0.538 |
MEKK2 |
0.798 | 0.046 | 2 | 0.801 |
HIPK2 |
0.798 | 0.013 | 1 | 0.446 |
TAO3 |
0.797 | 0.060 | 1 | 0.664 |
CDK17 |
0.797 | -0.009 | 1 | 0.409 |
MARK3 |
0.797 | -0.016 | 4 | 0.708 |
CAMK2A |
0.797 | -0.030 | 2 | 0.761 |
TLK2 |
0.797 | -0.049 | 1 | 0.605 |
CDK1 |
0.797 | -0.014 | 1 | 0.455 |
HIPK1 |
0.797 | 0.023 | 1 | 0.543 |
BRSK1 |
0.797 | -0.054 | -3 | 0.767 |
PINK1 |
0.796 | 0.004 | 1 | 0.693 |
MYLK4 |
0.796 | -0.015 | -2 | 0.729 |
CDK9 |
0.796 | -0.033 | 1 | 0.512 |
BMPR1B |
0.796 | -0.016 | 1 | 0.560 |
PHKG2 |
0.796 | -0.025 | -3 | 0.772 |
MST3 |
0.796 | 0.033 | 2 | 0.810 |
BRAF |
0.796 | -0.039 | -4 | 0.801 |
ERK1 |
0.796 | -0.017 | 1 | 0.504 |
MLK4 |
0.796 | -0.064 | 2 | 0.699 |
CLK4 |
0.795 | 0.009 | -3 | 0.736 |
P38B |
0.795 | -0.002 | 1 | 0.495 |
CDK16 |
0.795 | 0.033 | 1 | 0.433 |
CDK12 |
0.795 | -0.029 | 1 | 0.472 |
CDK14 |
0.795 | 0.027 | 1 | 0.521 |
MEKK1 |
0.795 | -0.039 | 1 | 0.674 |
DNAPK |
0.795 | -0.055 | 1 | 0.532 |
CLK1 |
0.795 | 0.015 | -3 | 0.720 |
P38G |
0.795 | -0.013 | 1 | 0.403 |
PLK3 |
0.795 | -0.022 | 2 | 0.747 |
BIKE |
0.794 | 0.574 | 1 | 0.904 |
SSTK |
0.794 | -0.014 | 4 | 0.747 |
PERK |
0.793 | 0.020 | -2 | 0.814 |
PKCI |
0.793 | 0.008 | 2 | 0.730 |
WNK4 |
0.793 | -0.067 | -2 | 0.777 |
ZAK |
0.793 | -0.085 | 1 | 0.622 |
PAK4 |
0.793 | 0.015 | -2 | 0.641 |
ACVR2A |
0.793 | 0.005 | -2 | 0.793 |
CAMK1G |
0.792 | -0.035 | -3 | 0.741 |
ACVR2B |
0.792 | -0.007 | -2 | 0.795 |
SMG1 |
0.792 | -0.110 | 1 | 0.587 |
CDK3 |
0.792 | 0.015 | 1 | 0.429 |
AKT3 |
0.792 | 0.081 | -3 | 0.614 |
HIPK3 |
0.792 | -0.009 | 1 | 0.562 |
PRP4 |
0.792 | 0.042 | -3 | 0.766 |
MAPKAPK5 |
0.792 | -0.104 | -3 | 0.708 |
MARK1 |
0.791 | -0.054 | 4 | 0.732 |
LKB1 |
0.791 | 0.066 | -3 | 0.815 |
MEKK3 |
0.791 | -0.098 | 1 | 0.666 |
SNRK |
0.791 | -0.162 | 2 | 0.666 |
DYRK1A |
0.791 | -0.013 | 1 | 0.557 |
ERK2 |
0.791 | -0.053 | 1 | 0.520 |
CDK2 |
0.790 | -0.043 | 1 | 0.522 |
CDK10 |
0.790 | 0.031 | 1 | 0.506 |
DCAMKL2 |
0.790 | -0.012 | -3 | 0.782 |
MEK5 |
0.790 | -0.141 | 2 | 0.815 |
MAK |
0.790 | 0.120 | -2 | 0.680 |
NEK4 |
0.790 | 0.029 | 1 | 0.686 |
P70S6K |
0.789 | -0.006 | -3 | 0.692 |
DYRK1B |
0.789 | -0.002 | 1 | 0.496 |
CAMKK1 |
0.789 | -0.036 | -2 | 0.742 |
AAK1 |
0.789 | 0.601 | 1 | 0.882 |
CLK2 |
0.789 | 0.049 | -3 | 0.723 |
TAO2 |
0.788 | 0.010 | 2 | 0.841 |
ALK2 |
0.788 | -0.057 | -2 | 0.737 |
TNIK |
0.788 | 0.108 | 3 | 0.810 |
HGK |
0.788 | 0.066 | 3 | 0.826 |
CAMKK2 |
0.788 | -0.013 | -2 | 0.735 |
PKCE |
0.788 | 0.038 | 2 | 0.708 |
TLK1 |
0.786 | -0.082 | -2 | 0.796 |
MINK |
0.786 | 0.067 | 1 | 0.684 |
DRAK1 |
0.786 | -0.136 | 1 | 0.561 |
CAMK1D |
0.785 | -0.000 | -3 | 0.674 |
MRCKB |
0.785 | 0.061 | -3 | 0.721 |
GCK |
0.785 | 0.048 | 1 | 0.671 |
SMMLCK |
0.785 | -0.029 | -3 | 0.786 |
NEK8 |
0.785 | -0.073 | 2 | 0.801 |
MST2 |
0.784 | 0.019 | 1 | 0.676 |
IRAK1 |
0.784 | -0.108 | -1 | 0.691 |
PKN1 |
0.784 | -0.008 | -3 | 0.712 |
NEK1 |
0.784 | 0.069 | 1 | 0.687 |
P38D |
0.783 | -0.003 | 1 | 0.443 |
LOK |
0.783 | 0.011 | -2 | 0.761 |
PDK1 |
0.783 | -0.026 | 1 | 0.648 |
DYRK3 |
0.783 | -0.003 | 1 | 0.535 |
KHS1 |
0.782 | 0.078 | 1 | 0.667 |
CDK6 |
0.782 | 0.010 | 1 | 0.520 |
NEK11 |
0.782 | -0.111 | 1 | 0.647 |
MEKK6 |
0.782 | -0.017 | 1 | 0.672 |
SGK1 |
0.782 | 0.061 | -3 | 0.596 |
ROCK2 |
0.781 | 0.078 | -3 | 0.765 |
DAPK3 |
0.781 | 0.028 | -3 | 0.768 |
MAP3K15 |
0.780 | -0.038 | 1 | 0.637 |
BUB1 |
0.780 | 0.085 | -5 | 0.807 |
MRCKA |
0.780 | 0.041 | -3 | 0.738 |
MST1 |
0.780 | 0.026 | 1 | 0.671 |
DYRK4 |
0.780 | -0.037 | 1 | 0.454 |
YSK1 |
0.779 | 0.017 | 2 | 0.797 |
HPK1 |
0.778 | 0.005 | 1 | 0.656 |
KHS2 |
0.778 | 0.072 | 1 | 0.666 |
TTBK1 |
0.778 | -0.140 | 2 | 0.652 |
PASK |
0.778 | -0.066 | -3 | 0.799 |
MOK |
0.777 | 0.057 | 1 | 0.574 |
NEK3 |
0.777 | -0.015 | 1 | 0.662 |
CDK4 |
0.776 | -0.025 | 1 | 0.462 |
BMPR1A |
0.776 | -0.065 | 1 | 0.534 |
GRK2 |
0.776 | -0.138 | -2 | 0.660 |
CK2A2 |
0.776 | 0.054 | 1 | 0.533 |
PKG1 |
0.776 | 0.015 | -2 | 0.590 |
GSK3A |
0.775 | -0.019 | 4 | 0.347 |
DMPK1 |
0.775 | 0.106 | -3 | 0.737 |
ERK7 |
0.775 | -0.034 | 2 | 0.483 |
SLK |
0.775 | -0.031 | -2 | 0.714 |
CHK2 |
0.774 | -0.004 | -3 | 0.623 |
CAMK1A |
0.774 | -0.002 | -3 | 0.641 |
CK1E |
0.773 | -0.092 | -3 | 0.437 |
EEF2K |
0.773 | -0.039 | 3 | 0.808 |
CK1G1 |
0.772 | -0.090 | -3 | 0.435 |
JNK1 |
0.771 | -0.044 | 1 | 0.446 |
TAK1 |
0.770 | -0.123 | 1 | 0.661 |
GSK3B |
0.770 | -0.076 | 4 | 0.335 |
SBK |
0.770 | 0.037 | -3 | 0.570 |
DAPK1 |
0.770 | -0.015 | -3 | 0.745 |
LRRK2 |
0.770 | -0.108 | 2 | 0.823 |
ROCK1 |
0.770 | 0.048 | -3 | 0.736 |
PDHK3_TYR |
0.769 | 0.216 | 4 | 0.851 |
MEK2 |
0.768 | -0.128 | 2 | 0.807 |
VRK1 |
0.768 | -0.131 | 2 | 0.837 |
TTK |
0.768 | 0.157 | -2 | 0.835 |
CRIK |
0.768 | 0.057 | -3 | 0.697 |
STK33 |
0.767 | -0.128 | 2 | 0.635 |
RIPK2 |
0.767 | -0.199 | 1 | 0.624 |
OSR1 |
0.765 | -0.012 | 2 | 0.801 |
CK1D |
0.765 | -0.084 | -3 | 0.396 |
MYO3B |
0.764 | 0.039 | 2 | 0.811 |
CK2A1 |
0.764 | 0.019 | 1 | 0.510 |
TAO1 |
0.762 | -0.022 | 1 | 0.628 |
CK1A2 |
0.762 | -0.092 | -3 | 0.393 |
MYO3A |
0.762 | 0.017 | 1 | 0.639 |
PKMYT1_TYR |
0.761 | 0.184 | 3 | 0.851 |
GRK3 |
0.760 | -0.129 | -2 | 0.608 |
LIMK2_TYR |
0.760 | 0.087 | -3 | 0.866 |
PLK2 |
0.759 | -0.068 | -3 | 0.654 |
TESK1_TYR |
0.759 | -0.003 | 3 | 0.867 |
MAP2K4_TYR |
0.759 | 0.122 | -1 | 0.817 |
HASPIN |
0.758 | -0.031 | -1 | 0.664 |
PDHK4_TYR |
0.756 | 0.026 | 2 | 0.855 |
MAP2K6_TYR |
0.756 | 0.078 | -1 | 0.825 |
MAP2K7_TYR |
0.755 | -0.079 | 2 | 0.839 |
ASK1 |
0.754 | -0.111 | 1 | 0.622 |
PINK1_TYR |
0.753 | -0.089 | 1 | 0.676 |
TYK2 |
0.752 | -0.050 | 1 | 0.657 |
LIMK1_TYR |
0.751 | -0.004 | 2 | 0.848 |
RET |
0.750 | -0.092 | 1 | 0.650 |
BMPR2_TYR |
0.750 | -0.059 | -1 | 0.804 |
PDHK1_TYR |
0.749 | -0.065 | -1 | 0.826 |
ROS1 |
0.749 | -0.032 | 3 | 0.791 |
NEK10_TYR |
0.748 | -0.010 | 1 | 0.602 |
YES1 |
0.748 | 0.128 | -1 | 0.747 |
LCK |
0.748 | 0.195 | -1 | 0.717 |
JAK2 |
0.748 | -0.082 | 1 | 0.644 |
EPHA6 |
0.748 | -0.012 | -1 | 0.781 |
FGR |
0.747 | 0.121 | 1 | 0.766 |
TNNI3K_TYR |
0.747 | 0.026 | 1 | 0.660 |
STLK3 |
0.746 | -0.113 | 1 | 0.616 |
MST1R |
0.746 | -0.098 | 3 | 0.810 |
TYRO3 |
0.746 | -0.078 | 3 | 0.811 |
TNK2 |
0.746 | 0.066 | 3 | 0.756 |
EPHB4 |
0.746 | -0.017 | -1 | 0.766 |
BLK |
0.745 | 0.196 | -1 | 0.738 |
TNK1 |
0.744 | 0.000 | 3 | 0.791 |
ABL2 |
0.744 | -0.009 | -1 | 0.723 |
HCK |
0.743 | 0.087 | -1 | 0.716 |
DDR1 |
0.742 | -0.122 | 4 | 0.765 |
JAK3 |
0.742 | -0.102 | 1 | 0.630 |
JAK1 |
0.742 | -0.013 | 1 | 0.627 |
INSRR |
0.740 | -0.063 | 3 | 0.776 |
TXK |
0.740 | 0.013 | 1 | 0.651 |
CSF1R |
0.739 | -0.121 | 3 | 0.795 |
PDGFRB |
0.739 | -0.111 | 3 | 0.812 |
ABL1 |
0.739 | -0.028 | -1 | 0.711 |
YANK3 |
0.737 | -0.074 | 2 | 0.428 |
ITK |
0.737 | -0.040 | -1 | 0.690 |
EPHB3 |
0.735 | -0.043 | -1 | 0.748 |
ALPHAK3 |
0.735 | -0.151 | -1 | 0.700 |
FER |
0.734 | -0.113 | 1 | 0.677 |
KDR |
0.734 | -0.095 | 3 | 0.756 |
FLT3 |
0.733 | -0.139 | 3 | 0.798 |
EPHB2 |
0.733 | -0.049 | -1 | 0.740 |
EPHB1 |
0.731 | -0.128 | 1 | 0.634 |
FGFR1 |
0.731 | -0.145 | 3 | 0.789 |
AXL |
0.730 | -0.126 | 3 | 0.780 |
FYN |
0.730 | 0.096 | -1 | 0.687 |
FGFR2 |
0.729 | -0.181 | 3 | 0.798 |
PDGFRA |
0.729 | -0.187 | 3 | 0.803 |
EPHA4 |
0.728 | -0.101 | 2 | 0.742 |
DDR2 |
0.728 | -0.044 | 3 | 0.766 |
SRMS |
0.728 | -0.143 | 1 | 0.641 |
ALK |
0.728 | -0.124 | 3 | 0.768 |
CK1A |
0.728 | -0.108 | -3 | 0.305 |
KIT |
0.728 | -0.170 | 3 | 0.799 |
INSR |
0.728 | -0.103 | 3 | 0.755 |
MERTK |
0.727 | -0.115 | 3 | 0.770 |
LTK |
0.727 | -0.104 | 3 | 0.776 |
LYN |
0.726 | 0.034 | 3 | 0.741 |
MET |
0.726 | -0.126 | 3 | 0.783 |
BTK |
0.726 | -0.139 | -1 | 0.644 |
BMX |
0.725 | -0.094 | -1 | 0.608 |
TEK |
0.724 | -0.200 | 3 | 0.759 |
NTRK2 |
0.724 | -0.151 | 3 | 0.759 |
TEC |
0.723 | -0.126 | -1 | 0.626 |
NTRK1 |
0.723 | -0.172 | -1 | 0.743 |
WEE1_TYR |
0.723 | -0.108 | -1 | 0.662 |
SRC |
0.722 | 0.063 | -1 | 0.691 |
FLT1 |
0.722 | -0.131 | -1 | 0.751 |
EPHA1 |
0.721 | -0.123 | 3 | 0.762 |
EPHA7 |
0.721 | -0.118 | 2 | 0.752 |
EPHA3 |
0.720 | -0.124 | 2 | 0.723 |
NTRK3 |
0.720 | -0.126 | -1 | 0.694 |
FLT4 |
0.719 | -0.177 | 3 | 0.756 |
PTK6 |
0.718 | -0.170 | -1 | 0.612 |
ERBB2 |
0.718 | -0.190 | 1 | 0.598 |
FGFR3 |
0.717 | -0.192 | 3 | 0.775 |
FRK |
0.717 | -0.156 | -1 | 0.732 |
PTK2B |
0.716 | -0.092 | -1 | 0.677 |
EPHA5 |
0.713 | -0.114 | 2 | 0.723 |
MUSK |
0.712 | -0.119 | 1 | 0.548 |
EGFR |
0.711 | -0.124 | 1 | 0.513 |
EPHA8 |
0.710 | -0.125 | -1 | 0.725 |
MATK |
0.709 | -0.165 | -1 | 0.664 |
CSK |
0.707 | -0.185 | 2 | 0.762 |
IGF1R |
0.707 | -0.146 | 3 | 0.706 |
CK1G3 |
0.706 | -0.118 | -3 | 0.259 |
FGFR4 |
0.705 | -0.152 | -1 | 0.682 |
YANK2 |
0.704 | -0.100 | 2 | 0.445 |
PTK2 |
0.704 | -0.080 | -1 | 0.696 |
EPHA2 |
0.698 | -0.149 | -1 | 0.684 |
ERBB4 |
0.695 | -0.126 | 1 | 0.498 |
SYK |
0.695 | -0.145 | -1 | 0.679 |
ZAP70 |
0.684 | -0.115 | -1 | 0.621 |
FES |
0.683 | -0.190 | -1 | 0.582 |
CK1G2 |
0.679 | -0.140 | -3 | 0.351 |