Motif 831 (n=123)
Position-wise Probabilities
Download
| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| H0YC42 | None | S151 | ochoa | Tumor protein D52 | None |
| H3BQZ7 | HNRNPUL2-BSCL2 | S543 | ochoa | Heterogeneous nuclear ribonucleoprotein U-like protein 2 | None |
| O00151 | PDLIM1 | S187 | ochoa | PDZ and LIM domain protein 1 (C-terminal LIM domain protein 1) (Elfin) (LIM domain protein CLP-36) | Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (PubMed:10861853). Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts (By similarity). {ECO:0000250|UniProtKB:P52944, ECO:0000269|PubMed:10861853}. |
| O14976 | GAK | S182 | ochoa | Cyclin-G-associated kinase (EC 2.7.11.1) (DnaJ homolog subfamily C member 26) | Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 (PubMed:10625686). May play a role in clathrin-mediated endocytosis and intracellular trafficking, and in the dynamics of clathrin assembly/disassembly (PubMed:18489706). {ECO:0000269|PubMed:10625686, ECO:0000269|PubMed:18489706}. |
| O43399 | TPD52L2 | S141 | ochoa | Tumor protein D54 (hD54) (Tumor protein D52-like 2) | None |
| O43663 | PRC1 | S557 | ochoa | Protein regulator of cytokinesis 1 | Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436). {ECO:0000269|PubMed:12082078, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:17409436, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:20691902, ECO:0000269|PubMed:9885575}. |
| O43815 | STRN | S239 | ochoa | Striatin | Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). {ECO:0000269|PubMed:18782753, ECO:0000305|PubMed:26876214}. |
| O94885 | SASH1 | S701 | ochoa | SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) | Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). {ECO:0000269|PubMed:23333244, ECO:0000269|PubMed:23776175, ECO:0000269|PubMed:25315659}. |
| O94916 | NFAT5 | S248 | ochoa | Nuclear factor of activated T-cells 5 (NF-AT5) (T-cell transcription factor NFAT5) (Tonicity-responsive enhancer-binding protein) (TonE-binding protein) (TonEBP) | Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3' (PubMed:10377394). Mediates the transcriptional response to hypertonicity (PubMed:10051678). Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17 (PubMed:22266867). Also involved in the DNA damage response by preventing formation of R-loops; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:34049076). {ECO:0000269|PubMed:10051678, ECO:0000269|PubMed:10377394, ECO:0000269|PubMed:22266867, ECO:0000269|PubMed:34049076}. |
| O94927 | HAUS5 | S71 | ochoa | HAUS augmin-like complex subunit 5 | Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. {ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}. |
| O95425 | SVIL | S467 | ochoa | Supervillin (Archvillin) (p205/p250) | [Isoform 1]: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699). Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (PubMed:19109420). {ECO:0000269|PubMed:12711699, ECO:0000269|PubMed:19109420}.; FUNCTION: [Isoform 2]: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity). {ECO:0000250|UniProtKB:O46385}. |
| O95425 | SVIL | S1168 | ochoa | Supervillin (Archvillin) (p205/p250) | [Isoform 1]: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699). Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (PubMed:19109420). {ECO:0000269|PubMed:12711699, ECO:0000269|PubMed:19109420}.; FUNCTION: [Isoform 2]: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity). {ECO:0000250|UniProtKB:O46385}. |
| P00533 | EGFR | S768 | psp | Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1) | Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:10805725, PubMed:27153536, PubMed:2790960, PubMed:35538033). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:12297049, PubMed:15611079, PubMed:17909029, PubMed:20837704, PubMed:27153536, PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity). Plays a role in mammalian pain signaling (long-lasting hypersensitivity) (By similarity). {ECO:0000250|UniProtKB:Q01279, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11116146, ECO:0000269|PubMed:11483589, ECO:0000269|PubMed:11602604, ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12873986, ECO:0000269|PubMed:15374980, ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:15611079, ECO:0000269|PubMed:17115032, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:19560417, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:27153536, ECO:0000269|PubMed:2790960, ECO:0000269|PubMed:35538033, ECO:0000269|PubMed:7679104, ECO:0000269|PubMed:8144591, ECO:0000269|PubMed:9419975}.; FUNCTION: Isoform 2 may act as an antagonist of EGF action.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}. |
| P04083 | ANXA1 | S182 | ochoa | Annexin A1 (Annexin I) (Annexin-1) (Calpactin II) (Calpactin-2) (Chromobindin-9) (Lipocortin I) (Phospholipase A2 inhibitory protein) (p35) [Cleaved into: Annexin Ac2-26] | Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity). {ECO:0000250|UniProtKB:P10107, ECO:0000250|UniProtKB:P19619, ECO:0000269|PubMed:17008549, ECO:0000269|PubMed:19625660, ECO:0000269|PubMed:2532504, ECO:0000269|PubMed:2936963, ECO:0000269|PubMed:8425544, ECO:0000269|PubMed:8557678}.; FUNCTION: [Annexin Ac2-26]: Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:15187149, PubMed:22879591, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Promotes resolution of inflammation and wound healing (PubMed:25664854). Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2 (PubMed:22879591). {ECO:0000269|PubMed:15187149, ECO:0000269|PubMed:22879591, ECO:0000269|PubMed:25664854}. |
| P06730 | EIF4E | S53 | psp | Eukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (eIF-4F 25 kDa subunit) (mRNA cap-binding protein) | Acts in the cytoplasm to initiate and regulate protein synthesis and is required in the nucleus for export of a subset of mRNAs from the nucleus to the cytoplasm which promotes processes such as RNA capping, processing and splicing (PubMed:11606200, PubMed:22578813, PubMed:22684010, PubMed:24335285, PubMed:29987188). Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (By similarity). This protein recognizes and binds the 7-methylguanosine (m7G)-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures (PubMed:16271312, PubMed:22578813). Together with EIF4G1, antagonizes the scanning promoted by EIF1-EIF4G1 and is required for TISU translation, a process where the TISU element recognition makes scanning unnecessary (PubMed:29987188). In addition to its role in translation initiation, also acts as a regulator of translation and stability in the cytoplasm (PubMed:24335285). Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression: in the complex, EIF4E mediates the binding to the mRNA cap (By similarity). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). In P-bodies, component of a complex that mediates the storage of translationally inactive mRNAs in the cytoplasm and prevents their degradation (PubMed:24335285). May play an important role in spermatogenesis through translational regulation of stage-specific mRNAs during germ cell development (By similarity). As well as its roles in translation, also involved in mRNA nucleocytoplasmic transport (By similarity). Its role in mRNA export from the nucleus to the cytoplasm relies on its ability to bind the m7G cap of RNAs and on the presence of the 50-nucleotide EIF4E sensitivity element (4ESE) in the 3'UTR of sensitive transcripts (By similarity). Interaction with the 4ESE is mediated by LRPPRC which binds simultaneously to both EIF4E and the 4ESE, thereby acting as a platform for assembly for the RNA export complex (By similarity). EIF4E-dependent mRNA export is independent of ongoing protein or RNA synthesis and is also NFX1-independent but is XPO1-dependent with LRPPRC interacting with XPO1 to form an EIF4E-dependent mRNA export complex (By similarity). Alters the composition of the cytoplasmic face of the nuclear pore to promote RNA export by reducing RANBP2 expression, relocalizing nucleoporin NUP214 and increasing expression of RANBP1 and RNA export factors DDX19 and GLE1 (By similarity). Promotes the nuclear export of cyclin CCND1 mRNA (By similarity). Promotes the nuclear export of NOS2/iNOS mRNA (PubMed:23471078). Promotes the nuclear export of MDM2 mRNA (PubMed:22684010). Promotes the export of additional mRNAs, including others involved in the cell cycle (By similarity). In the nucleus, binds to capped splice factor-encoding mRNAs and stimulates their nuclear export to enhance splice factor production by increasing their cytoplasmic availability to the translation machinery (By similarity). May also regulate splicing through interaction with the spliceosome in an RNA and m7G cap-dependent manner (By similarity). Also binds to some pre-mRNAs and may play a role in their recruitment to the spliceosome (By similarity). Promotes steady-state capping of a subset of coding and non-coding RNAs by mediating nuclear export of capping machinery mRNAs including RNMT, RNGTT and RAMAC to enhance their translation (By similarity). Stimulates mRNA 3'-end processing by promoting the expression of several core cleavage complex factors required for mRNA cleavage and polyadenylation, and may also have a direct effect through its interaction with the CPSF3 cleavage enzyme (By similarity). Rescues cells from apoptosis by promoting activation of serine/threonine-protein kinase AKT1 through mRNA export of NBS1 which potentiates AKT1 phosphorylation and also through mRNA export of AKT1 effectors, allowing for increased production of these proteins (By similarity). {ECO:0000250|UniProtKB:P63073, ECO:0000250|UniProtKB:P63074, ECO:0000269|PubMed:11606200, ECO:0000269|PubMed:16271312, ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:22684010, ECO:0000269|PubMed:23471078, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:29987188}. |
| P08069 | IGF1R | S975 | ochoa | Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] | Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R. IGF1 exerts inhibiting activities on JNK activation via phosphorylation and inhibition of MAP3K5/ASK1, which is able to directly associate with the IGF1R.; FUNCTION: When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin. |
| P09211 | GSTP1 | S135 | ochoa | Glutathione S-transferase P (EC 2.5.1.18) (GST class-pi) (GSTP1-1) | Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). Participates in the formation of novel hepoxilin regioisomers (PubMed:21046276). Negatively regulates CDK5 activity via p25/p35 translocation to prevent neurodegeneration. {ECO:0000269|PubMed:21046276, ECO:0000269|PubMed:21668448, ECO:0000269|PubMed:9084911}. |
| P0DMV8 | HSPA1A | Y41 | ochoa | Heat shock 70 kDa protein 1A (Heat shock 70 kDa protein 1) (HSP70-1) (HSP70.1) (Heat shock protein family A member 1A) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:24318877, PubMed:26865365). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). Required as a co-chaperone for optimal STUB1/CHIP ubiquitination of NFATC3 (By similarity). Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Involved in the clearance of misfolded PRDM1/Blimp-1 proteins. Sequesters them in the cytoplasm and promotes their association with SYNV1/HRD1, leading to proteasomal degradation (PubMed:28842558). {ECO:0000250|UniProtKB:P0DMW0, ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:27137183, ECO:0000269|PubMed:27708256, ECO:0000269|PubMed:28842558, ECO:0000269|PubMed:9499401, ECO:0000303|PubMed:24012426, ECO:0000303|PubMed:26865365}.; FUNCTION: (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. {ECO:0000269|PubMed:16537599}. |
| P0DMV9 | HSPA1B | Y41 | ochoa | Heat shock 70 kDa protein 1B (Heat shock 70 kDa protein 2) (HSP70-2) (HSP70.2) (Heat shock protein family A member 1B) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:24318877, PubMed:26865365). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). {ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:27137183, ECO:0000269|PubMed:27708256, ECO:0000303|PubMed:24012426, ECO:0000303|PubMed:26865365}.; FUNCTION: (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. {ECO:0000269|PubMed:16537599}. |
| P11142 | HSPA8 | Y41 | ochoa | Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins, formation and dissociation of protein complexes, and antigen presentation. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661, PubMed:2799391, PubMed:36586411). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24121476, PubMed:24318877, PubMed:26865365, PubMed:27474739). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2 (PubMed:11559757, PubMed:2799391, PubMed:36586411). KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded (PubMed:11559757, PubMed:2799391, PubMed:36586411). In conjunction with LAMP2, facilitates MHC class II presentation of cytoplasmic antigens by guiding antigens to the lysosomal membrane for interaction with LAMP2 which then elicits MHC class II presentation of peptides to the cell membrane (PubMed:15894275). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). It is recruited to clathrin-coated vesicles through its interaction with DNAJC6 leading to activation of HSPA8/HSC70 ATPase activity and therefore uncoating of clathrin-coated vesicles (By similarity). {ECO:0000250|UniProtKB:P19120, ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:11559757, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15894275, ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27916661, ECO:0000269|PubMed:2799391, ECO:0000269|PubMed:36586411, ECO:0000303|PubMed:24121476, ECO:0000303|PubMed:26865365}. |
| P12883 | MYH7 | S1630 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P13533 | MYH6 | S1632 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P17066 | HSPA6 | Y43 | ochoa | Heat shock 70 kDa protein 6 (Heat shock 70 kDa protein B') (Heat shock protein family A member 6) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). {ECO:0000303|PubMed:26865365}. |
| P29350 | PTPN6 | S534 | ochoa | Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Protein-tyrosine phosphatase SHP-1) (SH-PTP1) | Tyrosine phosphatase enzyme that plays important roles in controlling immune signaling pathways and fundamental physiological processes such as hematopoiesis (PubMed:14739280, PubMed:29925997). Dephosphorylates and negatively regulate several receptor tyrosine kinases (RTKs) such as EGFR, PDGFR and FGFR, thereby modulating their signaling activities (PubMed:21258366, PubMed:9733788). When recruited to immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing receptors such as immunoglobulin-like transcript 2/LILRB1, programmed cell death protein 1/PDCD1, CD3D, CD22, CLEC12A and other receptors involved in immune regulation, initiates their dephosphorylation and subsequently inhibits downstream signaling events (PubMed:11907092, PubMed:14739280, PubMed:37932456, PubMed:38166031). Modulates the signaling of several cytokine receptors including IL-4 receptor (PubMed:9065461). Additionally, targets multiple cytoplasmic signaling molecules including STING1, LCK or STAT1 among others involved in diverse cellular processes including modulation of T-cell activation or cGAS-STING signaling (PubMed:34811497, PubMed:38532423). Within the nucleus, negatively regulates the activity of some transcription factors such as NFAT5 via direct dephosphorylation. Also acts as a key transcriptional regulator of hepatic gluconeogenesis by controlling recruitment of RNA polymerase II to the PCK1 promoter together with STAT5A (PubMed:37595871). {ECO:0000269|PubMed:10574931, ECO:0000269|PubMed:11266449, ECO:0000269|PubMed:11907092, ECO:0000269|PubMed:14739280, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:29925997, ECO:0000269|PubMed:34811497, ECO:0000269|PubMed:37595871, ECO:0000269|PubMed:37932456, ECO:0000269|PubMed:38166031, ECO:0000269|PubMed:38532423, ECO:0000269|PubMed:9065461, ECO:0000269|PubMed:9733788}. |
| P31629 | HIVEP2 | S1616 | ochoa | Transcription factor HIVEP2 (Human immunodeficiency virus type I enhancer-binding protein 2) (HIV-EP2) (MHC-binding protein 2) (MBP-2) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation. |
| P34931 | HSPA1L | Y43 | ochoa | Heat shock 70 kDa protein 1-like (Heat shock 70 kDa protein 1L) (Heat shock 70 kDa protein 1-Hom) (HSP70-Hom) (Heat shock protein family A member 1L) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Positive regulator of PRKN translocation to damaged mitochondria (PubMed:24270810). {ECO:0000269|PubMed:24270810, ECO:0000303|PubMed:26865365}. |
| P35240 | NF2 | S566 | ochoa | Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomerlin) (Schwannomin) | Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:20159598, ECO:0000269|PubMed:20178741, ECO:0000269|PubMed:21167305}. |
| P35573 | AGL | S1027 | ochoa | Glycogen debranching enzyme (Glycogen debrancher) [Includes: 4-alpha-glucanotransferase (EC 2.4.1.25) (Oligo-1,4-1,4-glucantransferase); Amylo-alpha-1,6-glucosidase (Amylo-1,6-glucosidase) (EC 3.2.1.33) (Dextrin 6-alpha-D-glucosidase)] | Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. |
| P38432 | COIL | S447 | ochoa | Coilin (p80-coilin) | Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs. {ECO:0000269|PubMed:7679389}. |
| P40121 | CAPG | S318 | ochoa | Macrophage-capping protein (Actin regulatory protein CAP-G) | Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA. |
| P46089 | GPR3 | S237 | psp | G-protein coupled receptor 3 (ACCA orphan receptor) | Constitutively active G-protein coupled receptor that maintains high 3'-5'-cyclic adenosine monophosphate (cAMP) levels that a plays a role in serveral processes including meiotic arrest in oocytes or neuronal development via activation of numerous intracellular signaling pathways. Acts as an essential activator of thermogenic adipocytes and drives thermogenesis via its intrinsic G(s)-coupling activity without the requirement of a ligand (PubMed:34048700). Has a potential role in modulating a number of brain functions, including behavioral responses to stress (By similarity), amyloid-beta peptide generation in neurons (By similarity). Stimulates neurite outgrowth in cerebellar granular neurons modulated via PKA, ERK, and most strongly PI3K-mediated signaling pathways (By similarity). {ECO:0000250|UniProtKB:P35413, ECO:0000269|PubMed:19213921, ECO:0000269|PubMed:34048700}. |
| P48741 | HSPA7 | Y43 | ochoa | Putative heat shock 70 kDa protein 7 (Heat shock 70 kDa protein B) (Heat shock protein family A member 7) | None |
| P49748 | ACADVL | S57 | ochoa | Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (VLCAD) (EC 1.3.8.9) | Very long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats (PubMed:18227065, PubMed:7668252, PubMed:9461620, PubMed:9599005, PubMed:9839948). The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (PubMed:18227065, PubMed:7668252, PubMed:9461620, PubMed:9839948). Among the different mitochondrial acyl-CoA dehydrogenases, very long-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 12 to 24 carbons long primary chains (PubMed:21237683, PubMed:9839948). {ECO:0000269|PubMed:18227065, ECO:0000269|PubMed:21237683, ECO:0000269|PubMed:7668252, ECO:0000269|PubMed:9461620, ECO:0000269|PubMed:9599005, ECO:0000269|PubMed:9839948}. |
| P49790 | NUP153 | S306 | ochoa | Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}. |
| P50458 | LHX2 | S245 | ochoa | LIM/homeobox protein Lhx2 (Homeobox protein LH-2) (LIM homeobox protein 2) | Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types (By similarity). {ECO:0000250}. |
| P54652 | HSPA2 | Y42 | ochoa | Heat shock-related 70 kDa protein 2 (Heat shock 70 kDa protein 2) (Heat shock protein family A member 2) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Plays a role in spermatogenesis. In association with SHCBP1L may participate in the maintenance of spindle integrity during meiosis in male germ cells (By similarity). {ECO:0000250|UniProtKB:P17156, ECO:0000303|PubMed:26865365}. |
| P56182 | RRP1 | S315 | ochoa | Ribosomal RNA processing protein 1 homolog A (Novel nuclear protein 1) (NNP-1) (Nucleolar protein Nop52) (RRP1-like protein) | Plays a critical role in the generation of 28S rRNA. {ECO:0000269|PubMed:10341208}. |
| P60709 | ACTB | T229 | ochoa | Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] | Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (PubMed:39321809, PubMed:38609661). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:Q6QAQ1, ECO:0000269|PubMed:25255767, ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| P61313 | RPL15 | S100 | ochoa | Large ribosomal subunit protein eL15 (60S ribosomal protein L15) | Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| P62736 | ACTA2 | T231 | ochoa | Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P63261 | ACTG1 | T229 | ochoa | Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage (By similarity). {ECO:0000250|UniProtKB:P63260, ECO:0000305|PubMed:29581253}. |
| P63267 | ACTG2 | T230 | ochoa | Actin, gamma-enteric smooth muscle (EC 3.6.4.-) (Alpha-actin-3) (Gamma-2-actin) (Smooth muscle gamma-actin) [Cleaved into: Actin, gamma-enteric smooth muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P68032 | ACTC1 | T231 | ochoa | Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P68133 | ACTA1 | T231 | ochoa | Actin, alpha skeletal muscle (EC 3.6.4.-) (Alpha-actin-1) [Cleaved into: Actin, alpha skeletal muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P68363 | TUBA1B | S340 | ochoa | Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| P68366 | TUBA4A | S340 | ochoa | Tubulin alpha-4A chain (EC 3.6.5.-) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) (Tubulin alpha-1 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q00403 | GTF2B | S252 | ochoa | Transcription initiation factor IIB (EC 2.3.1.48) (General transcription factor TFIIB) (S300-II) | General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II). Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA (PubMed:12931194, PubMed:1517211, PubMed:1876184, PubMed:1946368, PubMed:27193682, PubMed:3029109, PubMed:3818643, PubMed:7601352, PubMed:8413225, PubMed:8515820, PubMed:8516311, PubMed:8516312, PubMed:9420329). Together with the TATA box-bound TBP forms the core initiation complex and provides a bridge between TBP and the Pol II-TFIIF complex (PubMed:8413225, PubMed:8504927, PubMed:8515820, PubMed:8516311, PubMed:8516312). Released from the PIC early following the onset of transcription during the initiation and elongation transition and reassociates with TBP during the next transcription cycle (PubMed:7601352). Associates with chromatin to core promoter-specific regions (PubMed:12931194, PubMed:24441171). Binds to two distinct DNA core promoter consensus sequence elements in a TBP-independent manner; these IIB-recognition elements (BREs) are localized immediately upstream (BREu), 5'-[GC][GC][GA]CGCC-3', and downstream (BREd), 5'-[GA]T[TGA][TG][GT][TG][TG]-3', of the TATA box element (PubMed:10619841, PubMed:16230532, PubMed:7675079, PubMed:9420329). Modulates transcription start site selection (PubMed:10318856). Also exhibits autoacetyltransferase activity that contributes to the activated transcription (PubMed:12931194). {ECO:0000269|PubMed:10318856, ECO:0000269|PubMed:10619841, ECO:0000269|PubMed:12931194, ECO:0000269|PubMed:1517211, ECO:0000269|PubMed:16230532, ECO:0000269|PubMed:1876184, ECO:0000269|PubMed:1946368, ECO:0000269|PubMed:24441171, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:3029109, ECO:0000269|PubMed:3818643, ECO:0000269|PubMed:7601352, ECO:0000269|PubMed:7675079, ECO:0000269|PubMed:8413225, ECO:0000269|PubMed:8504927, ECO:0000269|PubMed:8515820, ECO:0000269|PubMed:8516311, ECO:0000269|PubMed:8516312, ECO:0000269|PubMed:9420329}. |
| Q01831 | XPC | S347 | ochoa | DNA repair protein complementing XP-C cells (Xeroderma pigmentosum group C-complementing protein) (p125) | Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex (PubMed:10734143, PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19609301, PubMed:19941824, PubMed:20028083, PubMed:20649465, PubMed:20798892, PubMed:9734359). Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides (PubMed:10734143, PubMed:19609301, PubMed:20649465). This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity (PubMed:10734143, PubMed:19609301, PubMed:20649465). The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). The orientation of XPC complex binding appears to be crucial for inducing a productive NER (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts (PubMed:20028083). XPC:RAD23B contacts DNA both 5' and 3' of a cisplatin lesion with a preference for the 5' side. XPC:RAD23B induces a bend in DNA upon binding. XPC:RAD23B stimulates the activity of DNA glycosylases TDG and SMUG1 (PubMed:20028083). {ECO:0000269|PubMed:10734143, ECO:0000269|PubMed:10873465, ECO:0000269|PubMed:12509299, ECO:0000269|PubMed:12547395, ECO:0000269|PubMed:19609301, ECO:0000269|PubMed:19941824, ECO:0000269|PubMed:20028083, ECO:0000269|PubMed:20649465, ECO:0000269|PubMed:20798892, ECO:0000269|PubMed:9734359}.; FUNCTION: In absence of DNA repair, the XPC complex also acts as a transcription coactivator: XPC interacts with the DNA-binding transcription factor E2F1 at a subset of promoters to recruit KAT2A and histone acetyltransferase complexes (HAT) (PubMed:29973595, PubMed:31527837). KAT2A recruitment specifically promotes acetylation of histone variant H2A.Z.1/H2A.Z, but not H2A.Z.2/H2A.V, thereby promoting expression of target genes (PubMed:31527837). {ECO:0000269|PubMed:29973595, ECO:0000269|PubMed:31527837}. |
| Q09666 | AHNAK | S5500 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q10571 | MN1 | S815 | ochoa | Transcriptional activator MN1 (Probable tumor suppressor protein MN1) | Transcriptional activator which specifically regulates expression of TBX22 in the posterior region of the developing palate. Required during later stages of palate development for growth and medial fusion of the palatal shelves. Promotes maturation and normal function of calvarial osteoblasts, including expression of the osteoclastogenic cytokine TNFSF11/RANKL. Necessary for normal development of the membranous bones of the skull (By similarity). May play a role in tumor suppression (Probable). {ECO:0000250|UniProtKB:D3YWE6, ECO:0000305|PubMed:7731706}. |
| Q12931 | TRAP1 | S195 | ochoa | Heat shock protein 75 kDa, mitochondrial (HSP 75) (Heat shock protein family C member 5) (TNFR-associated protein 1) (Tumor necrosis factor type 1 receptor-associated protein) (TRAP-1) | Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA. {ECO:0000269|PubMed:23525905, ECO:0000269|PubMed:23564345, ECO:0000269|PubMed:23747254}. |
| Q13823 | GNL2 | S68 | ochoa | Nucleolar GTP-binding protein 2 (Autoantigen NGP-1) | GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (PubMed:32669547). May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels (PubMed:26203195). {ECO:0000269|PubMed:26203195, ECO:0000269|PubMed:32669547}. |
| Q15056 | EIF4H | S230 | ochoa | Eukaryotic translation initiation factor 4H (eIF-4H) (Williams-Beuren syndrome chromosomal region 1 protein) | Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA. {ECO:0000269|PubMed:10585411, ECO:0000269|PubMed:11418588}. |
| Q15437 | SEC23B | S186 | psp | Protein transport protein Sec23B (hSec23B) (SEC23-related protein B) | Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. {ECO:0000250|UniProtKB:Q15436}. |
| Q16706 | MAN2A1 | S943 | ochoa | Alpha-mannosidase 2 (EC 3.2.1.114) (Golgi alpha-mannosidase II) (AMan II) (Man II) (Mannosidase alpha class 2A member 1) (Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase) | Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway. {ECO:0000250|UniProtKB:P28494}. |
| Q16825 | PTPN21 | S480 | ochoa | Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1) | None |
| Q1KMD3 | HNRNPUL2 | S543 | ochoa | Heterogeneous nuclear ribonucleoprotein U-like protein 2 (Scaffold-attachment factor A2) (SAF-A2) | None |
| Q29RF7 | PDS5A | S1149 | ochoa | Sister chromatid cohesion protein PDS5 homolog A (Cell proliferation-inducing gene 54 protein) (Sister chromatid cohesion protein 112) (SCC-112) | Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15855230, ECO:0000269|PubMed:19907496}. |
| Q49AR2 | C5orf22 | S192 | ochoa | UPF0489 protein C5orf22 | None |
| Q4V328 | GRIPAP1 | S318 | ochoa | GRIP1-associated protein 1 (GRASP-1) [Cleaved into: GRASP-1 C-terminal chain (30kDa C-terminus form)] | Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of recycling endosomes from early endosomal membranes. Involved in the localization of recycling endosomes to dendritic spines, thereby playing a role in the maintenance of dendritic spine morphology. Required for the activity-induced AMPA receptor recycling to dendrite membranes and for long-term potentiation and synaptic plasticity (By similarity). {ECO:0000250|UniProtKB:Q9JHZ4}.; FUNCTION: [GRASP-1 C-terminal chain]: Functions as a scaffold protein to facilitate MAP3K1/MEKK1-mediated activation of the JNK1 kinase by phosphorylation, possibly by bringing MAP3K1/MEKK1 and JNK1 in close proximity. {ECO:0000269|PubMed:17761173}. |
| Q53GL7 | PARP10 | S143 | ochoa | Protein mono-ADP-ribosyltransferase PARP10 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 10) (ARTD10) (Poly [ADP-ribose] polymerase 10) (PARP-10) | ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate and aspartate residues on target proteins (PubMed:18851833, PubMed:23332125, PubMed:23474714, PubMed:25043379). In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (PubMed:18851833). Catalyzes mono-ADP-ribosylation of GSK3B, leading to negatively regulate GSK3B kinase activity (PubMed:23332125). Involved in translesion DNA synthesis in response to DNA damage via its interaction with PCNA (PubMed:24695737). {ECO:0000269|PubMed:18851833, ECO:0000269|PubMed:23332125, ECO:0000269|PubMed:23474714, ECO:0000269|PubMed:24695737, ECO:0000269|PubMed:25043379}. |
| Q5T5P2 | KIAA1217 | S526 | ochoa | Sickle tail protein homolog | Required for normal development of intervertebral disks. {ECO:0000250|UniProtKB:A2AQ25}. |
| Q6KC79 | NIPBL | S1196 | ochoa | Nipped-B-like protein (Delangin) (SCC2 homolog) | Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}. |
| Q6PJT7 | ZC3H14 | S581 | ochoa | Zinc finger CCCH domain-containing protein 14 (Mammalian suppressor of tau pathology-2) (MSUT-2) (Renal carcinoma antigen NY-REN-37) | RNA-binding protein involved in the biogenesis of circular RNAs (circRNAs), which are produced by back-splicing circularization of pre-mRNAs (PubMed:39461343). Acts by binding to both exon-intron boundary and 3'-UTR of pre-mRNAs to promote circRNA biogenesis through dimerization and the association with the spliceosome (PubMed:39461343). Required for spermatogenesis via involvement in circRNA biogenesis (PubMed:39461343). Regulates the pre-mRNA processing of ATP5MC1; preventing its degradation (PubMed:27563065). Also binds the poly(A) tail of mRNAs; controlling poly(A) length in neuronal cells (PubMed:17630287, PubMed:24671764). {ECO:0000269|PubMed:17630287, ECO:0000269|PubMed:24671764, ECO:0000269|PubMed:27563065, ECO:0000269|PubMed:39461343}. |
| Q6S8J3 | POTEE | T929 | ochoa | POTE ankyrin domain family member E (ANKRD26-like family C member 1A) (Prostate, ovary, testis-expressed protein on chromosome 2) (POTE-2) | None |
| Q6UX04 | CWC27 | S266 | ochoa | Spliceosome-associated protein CWC27 homolog (Antigen NY-CO-10) (Probable inactive peptidyl-prolyl cis-trans isomerase CWC27 homolog) (PPIase CWC27) (Serologically defined colon cancer antigen 10) | As part of the spliceosome, plays a role in pre-mRNA splicing (PubMed:29360106). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:29360106, ECO:0000305|PubMed:33509932}. |
| Q7Z6Z7 | HUWE1 | S2632 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q86UW2 | SLC51B | S88 | ochoa | Organic solute transporter subunit beta (OST-beta) (Solute carrier family 51 subunit beta) | Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood (PubMed:16317684). Modulates SLC51A glycosylation, membrane trafficking and stability activities (PubMed:16317684). The Ost-alpha/Ost-beta complex efficiently transports the major species of bile acids (taurocholate) (PubMed:16317684). Taurine conjugates are transported more efficiently across the basolateral membrane than glycine-conjugated bile acids (By similarity). Can also transport steroids such as estrone 3-sulfate and dehydroepiandrosterone 3-sulfate, therefore playing a role in the enterohepatic circulation of sterols (PubMed:16317684). Able to transport eicosanoids such as prostaglandin E2 (By similarity). {ECO:0000250|UniProtKB:Q8R000, ECO:0000250|UniProtKB:Q90YM5, ECO:0000269|PubMed:16317684}. |
| Q8IW35 | CEP97 | S545 | ochoa | Centrosomal protein of 97 kDa (Cep97) (Leucine-rich repeat and IQ domain-containing protein 2) | Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation (PubMed:17719545, PubMed:30375385). Required for recruitment of CCP110 to the centrosome (PubMed:17719545). {ECO:0000269|PubMed:17719545, ECO:0000269|PubMed:30375385}. |
| Q8IX90 | SKA3 | S313 | ochoa | Spindle and kinetochore-associated protein 3 | Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:19289083, PubMed:19360002, PubMed:23085020). The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (PubMed:19289083, PubMed:19360002). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (PubMed:19289083). In the complex, it mediates the microtubule-stimulated oligomerization (PubMed:19289083). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020). {ECO:0000269|PubMed:19289083, ECO:0000269|PubMed:19360002, ECO:0000269|PubMed:23085020}. |
| Q8N0Z3 | SPICE1 | S314 | ochoa | Spindle and centriole-associated protein 1 (Coiled-coil domain-containing protein 52) (Spindle and centriole-associated protein) | Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome congression in mitosis. {ECO:0000269|PubMed:20736305}. |
| Q8N4C6 | NIN | S1965 | ochoa | Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein) | Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells (PubMed:15190203, PubMed:23386061). May also act as a centrosome maturation factor (PubMed:11956314). May play a role in microtubule nucleation, by recruiting the gamma-tubulin ring complex to the centrosome (PubMed:15190203). Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules (PubMed:15190203). Required for centriole organization and microtubule anchoring at the mother centriole (PubMed:23386061). {ECO:0000269|PubMed:11956314, ECO:0000269|PubMed:15190203, ECO:0000269|PubMed:23386061}. |
| Q8N884 | CGAS | S201 | psp | Cyclic GMP-AMP synthase (cGAMP synthase) (cGAS) (h-cGAS) (EC 2.7.7.86) (2'3'-cGAMP synthase) (Mab-21 domain-containing protein 1) | Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (2',3'-cGAMP) from ATP and GTP and plays a key role in innate immunity (PubMed:21478870, PubMed:23258413, PubMed:23707061, PubMed:23707065, PubMed:23722159, PubMed:24077100, PubMed:24116191, PubMed:24462292, PubMed:25131990, PubMed:26300263, PubMed:29976794, PubMed:30799039, PubMed:31142647, PubMed:32814054, PubMed:33273464, PubMed:33542149, PubMed:37217469, PubMed:37802025). Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p] (PubMed:28214358, PubMed:28363908). Acts as a key DNA sensor: directly binds double-stranded DNA (dsDNA), inducing the formation of liquid-like droplets in which CGAS is activated, leading to synthesis of 2',3'-cGAMP, a second messenger that binds to and activates STING1, thereby triggering type-I interferon production (PubMed:28314590, PubMed:28363908, PubMed:29976794, PubMed:32817552, PubMed:33230297, PubMed:33606975, PubMed:35322803, PubMed:35438208, PubMed:35460603, PubMed:35503863). Preferentially recognizes and binds curved long dsDNAs of a minimal length of 40 bp (PubMed:30007416). Acts as a key foreign DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses (PubMed:28363908). Has antiviral activity by sensing the presence of dsDNA from DNA viruses in the cytoplasm (PubMed:28363908, PubMed:35613581). Also acts as an innate immune sensor of infection by retroviruses, such as HIV-2, by detecting the presence of reverse-transcribed DNA in the cytosol (PubMed:23929945, PubMed:24269171, PubMed:30270045, PubMed:32852081). In contrast, HIV-1 is poorly sensed by CGAS, due to its capsid that cloaks viral DNA from CGAS detection (PubMed:24269171, PubMed:30270045, PubMed:32852081). Detection of retroviral reverse-transcribed DNA in the cytosol may be indirect and be mediated via interaction with PQBP1, which directly binds reverse-transcribed retroviral DNA (PubMed:26046437). Also detects the presence of DNA from bacteria, such as M.tuberculosis (PubMed:26048138). 2',3'-cGAMP can be transferred from producing cells to neighboring cells through gap junctions, leading to promote STING1 activation and convey immune response to connecting cells (PubMed:24077100). 2',3'-cGAMP can also be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but STING1-dependent manner (PubMed:26229115). Also senses the presence of neutrophil extracellular traps (NETs) that are translocated to the cytosol following phagocytosis, leading to synthesis of 2',3'-cGAMP (PubMed:33688080). In addition to foreign DNA, can also be activated by endogenous nuclear or mitochondrial DNA (PubMed:28738408, PubMed:28759889, PubMed:31299200, PubMed:33031745, PubMed:33230297). When self-DNA leaks into the cytosol during cellular stress (such as mitochondrial stress, SARS-CoV-2 infection causing severe COVID-19 disease, DNA damage, mitotic arrest or senescence), or is present in form of cytosolic micronuclei, CGAS is activated leading to a state of sterile inflammation (PubMed:28738408, PubMed:28759889, PubMed:31299200, PubMed:33031745, PubMed:33230297, PubMed:35045565). Acts as a regulator of cellular senescence by binding to cytosolic chromatin fragments that are present in senescent cells, leading to trigger type-I interferon production via STING1 and promote cellular senescence (By similarity). Also involved in the inflammatory response to genome instability and double-stranded DNA breaks: acts by localizing to micronuclei arising from genome instability (PubMed:28738408, PubMed:28759889). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, CGAS binds self-DNA exposed to the cytosol, leading to 2',3'-cGAMP synthesis and subsequent activation of STING1 and type-I interferon production (PubMed:28738408, PubMed:28759889). Activated in response to prolonged mitotic arrest, promoting mitotic cell death (PubMed:31299200). In a healthy cell, CGAS is however kept inactive even in cellular events that directly expose it to self-DNA, such as mitosis, when cGAS associates with chromatin directly after nuclear envelope breakdown or remains in the form of postmitotic persistent nuclear cGAS pools bound to chromatin (PubMed:31299200, PubMed:33542149). Nuclear CGAS is inactivated by chromatin via direct interaction with nucleosomes, which block CGAS from DNA binding and thus prevent CGAS-induced autoimmunity (PubMed:31299200, PubMed:32911482, PubMed:32912999, PubMed:33051594, PubMed:33542149). Also acts as a suppressor of DNA repair in response to DNA damage: inhibits homologous recombination repair by interacting with PARP1, the CGAS-PARP1 interaction leading to impede the formation of the PARP1-TIMELESS complex (PubMed:30356214, PubMed:31544964). In addition to DNA, also sense translation stress: in response to translation stress, translocates to the cytosol and associates with collided ribosomes, promoting its activation and triggering type-I interferon production (PubMed:34111399). In contrast to other mammals, human CGAS displays species-specific mechanisms of DNA recognition and produces less 2',3'-cGAMP, allowing a more fine-tuned response to pathogens (PubMed:30007416). {ECO:0000250|UniProtKB:Q8C6L5, ECO:0000269|PubMed:21478870, ECO:0000269|PubMed:23258413, ECO:0000269|PubMed:23707061, ECO:0000269|PubMed:23707065, ECO:0000269|PubMed:23722159, ECO:0000269|PubMed:23929945, ECO:0000269|PubMed:24077100, ECO:0000269|PubMed:24116191, ECO:0000269|PubMed:24269171, ECO:0000269|PubMed:24462292, ECO:0000269|PubMed:25131990, ECO:0000269|PubMed:26046437, ECO:0000269|PubMed:26048138, ECO:0000269|PubMed:26229115, ECO:0000269|PubMed:26300263, ECO:0000269|PubMed:28214358, ECO:0000269|PubMed:28314590, ECO:0000269|PubMed:28363908, ECO:0000269|PubMed:28738408, ECO:0000269|PubMed:28759889, ECO:0000269|PubMed:29976794, ECO:0000269|PubMed:30007416, ECO:0000269|PubMed:30270045, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:30799039, ECO:0000269|PubMed:31142647, ECO:0000269|PubMed:31299200, ECO:0000269|PubMed:31544964, ECO:0000269|PubMed:32814054, ECO:0000269|PubMed:32817552, ECO:0000269|PubMed:32852081, ECO:0000269|PubMed:32911482, ECO:0000269|PubMed:32912999, ECO:0000269|PubMed:33031745, ECO:0000269|PubMed:33051594, ECO:0000269|PubMed:33230297, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33542149, ECO:0000269|PubMed:33606975, ECO:0000269|PubMed:33688080, ECO:0000269|PubMed:34111399, ECO:0000269|PubMed:35045565, ECO:0000269|PubMed:35322803, ECO:0000269|PubMed:35438208, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:35503863, ECO:0000269|PubMed:35613581, ECO:0000269|PubMed:37217469, ECO:0000269|PubMed:37802025}. |
| Q8TD16 | BICD2 | S418 | ochoa | Protein bicaudal D homolog 2 (Bic-D 2) | Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25814576). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport via its interaction with RAB6A and recruitment of the dynein-dynactin motor complex (PubMed:25962623). Contributes to nuclear and centrosomal positioning prior to mitotic entry through regulation of both dynein and kinesin-1. During G2 phase of the cell cycle, associates with RANBP2 at the nuclear pores and recruits dynein and dynactin to the nuclear envelope to ensure proper positioning of the nucleus relative to centrosomes prior to the onset of mitosis (By similarity). {ECO:0000250|UniProtKB:Q921C5, ECO:0000269|PubMed:25814576, ECO:0000269|PubMed:25962623}. |
| Q8TEW0 | PARD3 | S850 | ochoa | Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) | Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:10954424, PubMed:27925688). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). {ECO:0000250|UniProtKB:Q99NH2, ECO:0000250|UniProtKB:Q9Z340, ECO:0000269|PubMed:10934474, ECO:0000269|PubMed:10954424, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:27925688}. |
| Q8TF05 | PPP4R1 | S538 | ochoa | Serine/threonine-protein phosphatase 4 regulatory subunit 1 | Regulatory subunit of serine/threonine-protein phosphatase 4. May play a role in regulation of cell division in renal glomeruli. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. Plays a role in the inhibition of TNF-induced NF-kappa-B activation by regulating the dephosphorylation of TRAF2. {ECO:0000269|PubMed:15805470}.; FUNCTION: (Microbial infection) Participates in merkel polyomavirus-mediated inhibition of NF-kappa-B by bridging viral small tumor antigen with NEMO. {ECO:0000269|PubMed:28445980}. |
| Q8WUY3 | PRUNE2 | S2345 | ochoa | Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1) | May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. {ECO:0000269|PubMed:16288218}. |
| Q8WWI1 | LMO7 | S1449 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q92560 | BAP1 | S289 | ochoa | Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1-associated protein 1) (Cerebral protein 6) | Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1 (PubMed:12485996, PubMed:18757409, PubMed:20436459, PubMed:25451922, PubMed:35051358). Catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-120' (H2AK119ub1) (PubMed:20436459, PubMed:25451922, PubMed:30664650, PubMed:35051358). Does not deubiquitinate monoubiquitinated histone H2B (PubMed:20436459, PubMed:30664650). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:20805357, PubMed:30664650, PubMed:36180891). Antagonizes PRC1 mediated H2AK119ub1 monoubiquitination (PubMed:30664650). As part of the PR-DUB complex, associates with chromatin enriched in histone marks H3K4me1, H3K4me3, and H3K27Ac, but not in H3K27me3 (PubMed:36180891). Recruited to specific gene-regulatory regions by YY1 (PubMed:20805357). Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains (PubMed:19188440, PubMed:19815555). Deubiquitination of HCFC1 does not lead to increase stability of HCFC1 (PubMed:19188440, PubMed:19815555). Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination (PubMed:19117993). It however does not mediate deubiquitination of BRCA1 and BARD1 (PubMed:19117993). Able to mediate autodeubiquitination via intramolecular interactions to counteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration (PubMed:24703950). Negatively regulates epithelial-mesenchymal transition (EMT) of trophoblast stem cells during placental development by regulating genes involved in epithelial cell integrity, cell adhesion and cytoskeletal organization (PubMed:34170818). {ECO:0000269|PubMed:12485996, ECO:0000269|PubMed:18757409, ECO:0000269|PubMed:19117993, ECO:0000269|PubMed:19188440, ECO:0000269|PubMed:19815555, ECO:0000269|PubMed:20436459, ECO:0000269|PubMed:20805357, ECO:0000269|PubMed:24703950, ECO:0000269|PubMed:25451922, ECO:0000269|PubMed:30664650, ECO:0000269|PubMed:34170818, ECO:0000269|PubMed:35051358, ECO:0000269|PubMed:36180891}. |
| Q92604 | LPGAT1 | S233 | ochoa | Acyl-CoA:lysophosphatidylglycerol acyltransferase 1 (2-acylglycerophosphocholine O-acyltransferase) (EC 2.3.1.62) (Acyl-CoA:monoacylglycerol acyltransferase LPGAT1) (EC 2.3.1.22) (Lysophospholipid acyltransferase 7) (LPLAT7) (EC 2.3.1.-) (Stearoyl-CoA:1-lyso-2-acyl-PE acyltransferase) | Lysophospholipid acyltransferase involved in fatty acyl chain remodeling of glycerophospholipids in the endoplasmic reticulum membrane (By similarity). Selectively catalyzes the transfer and esterification of saturated long-chain fatty acids from acyl-CoA to the sn-1 position of 1-lyso-2-acyl phosphatidylethanolamines (1-lyso-PE, LPE), with a preference for stearoyl CoA over palmitoyl CoA as acyl donor (PubMed:36049524). Acts in concert with an unknown phospholipase A1 to convert palmitate phosphatidylethanolamine (PE) species into stearate ones. Provides substrates to the PE methylation pathway, controlling stearate/palmitate composition of PE and phosphatidylcholine (PC) species with an overall impact on de novo hepatic lipid synthesis, body fat content and life span (By similarity). Can acylate lysophosphatidylglycerols (LPG) using various saturated fatty acyl-CoAs as acyl donors (PubMed:15485873). Can also acylate monoacylglycerols with a preference for 2-monoacylglycerols over 1-monoacylglycerols (By similarity). Has no activity toward lysophosphatidic acids (LPA) (By similarity). {ECO:0000250|UniProtKB:Q91YX5, ECO:0000269|PubMed:15485873, ECO:0000269|PubMed:36049524}. |
| Q92854 | SEMA4D | S780 | ochoa | Semaphorin-4D (A8) (BB18) (GR3) (CD antigen CD100) | Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling (PubMed:20877282). Regulates GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity). Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (PubMed:19788569). Promotes the migration of cerebellar granule cells (PubMed:16055703). Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro) (PubMed:8876214). Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway (PubMed:16055703). {ECO:0000250|UniProtKB:O09126, ECO:0000269|PubMed:16055703, ECO:0000269|PubMed:19788569, ECO:0000269|PubMed:20877282, ECO:0000269|PubMed:8876214}. |
| Q96BY6 | DOCK10 | S1232 | ochoa | Dedicator of cytokinesis protein 10 (Zizimin-3) | Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression. {ECO:0000250|UniProtKB:Q8BZN6}. |
| Q96HC4 | PDLIM5 | S85 | ochoa | PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein) | May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May be required to restrain postsynaptic growth of excitatory synapses. Isoform 1, but not isoform 2, expression favors spine thinning and elongation. {ECO:0000250|UniProtKB:Q62920}. |
| Q96KN1 | LRATD2 | S178 | ochoa | Protein LRATD2 (Breast cancer membrane protein 101) (LRAT domain-containing 2) (Protein FAM84B) (Protein NSE2) | None |
| Q96QD9 | FYTTD1 | S61 | ochoa | UAP56-interacting factor (Forty-two-three domain-containing protein 1) (Protein 40-2-3) | Required for mRNA export from the nucleus to the cytoplasm. Acts as an adapter that uses the DDX39B/UAP56-NFX1 pathway to ensure efficient mRNA export and delivering to the nuclear pore. Associates with spliced and unspliced mRNAs simultaneously with ALYREF/THOC4. {ECO:0000269|PubMed:19836239}. |
| Q96RE7 | NACC1 | S330 | ochoa | Nucleus accumbens-associated protein 1 (NAC-1) (BTB/POZ domain-containing protein 14B) | Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines. {ECO:0000269|PubMed:17130457, ECO:0000269|PubMed:17804717}. |
| Q96S59 | RANBP9 | S550 | psp | Ran-binding protein 9 (RanBP9) (BPM-L) (BPM90) (Ran-binding protein M) (RanBPM) (RanBP7) | May act as scaffolding protein, and as adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Acts as a mediator of cell spreading and actin cytoskeleton rearrangement (PubMed:18710924). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). May be involved in signaling of ITGB2/LFA-1 and other integrins (PubMed:14722085). Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway (PubMed:12147692). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation (PubMed:12361945, PubMed:18222118). Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity (PubMed:15558019). Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA. {ECO:0000269|PubMed:12147692, ECO:0000269|PubMed:12361945, ECO:0000269|PubMed:14500717, ECO:0000269|PubMed:14722085, ECO:0000269|PubMed:15381419, ECO:0000269|PubMed:15558019, ECO:0000269|PubMed:18222118, ECO:0000269|PubMed:18710924, ECO:0000269|PubMed:29911972, ECO:0000305}. |
| Q96T68 | SETDB2 | S318 | ochoa | Histone-lysine N-methyltransferase SETDB2 (EC 2.1.1.366) (Chronic lymphocytic leukemia deletion region gene 8 protein) (Lysine N-methyltransferase 1F) (SET domain bifurcated 2) | Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis. {ECO:0000269|PubMed:20404330}. |
| Q99623 | PHB2 | S161 | ochoa | Prohibitin-2 (B-cell receptor-associated protein BAP37) (D-prohibitin) (Repressor of estrogen receptor activity) | Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors and sex steroid hormones in the nucleus. {ECO:0000269|PubMed:10359819, ECO:0000269|PubMed:11302691, ECO:0000269|PubMed:20959514, ECO:0000269|PubMed:24003225, ECO:0000269|PubMed:28017329, ECO:0000269|PubMed:31522117}.; FUNCTION: In the mitochondria, together with PHB, forms large ring complexes (prohibitin complexes) in the inner mitochondrial membrane (IMM) and functions as a chaperone protein that stabilizes mitochondrial respiratory enzymes and maintains mitochondrial integrity in the IMM, which is required for mitochondrial morphogenesis, neuronal survival, and normal lifespan (Probable). The prohibitin complex, with DNAJC19, regulates cardiolipin remodeling and the protein turnover of OMA1 in a cardiolipin-binding manner (By similarity). Also regulates cytochrome-c oxidase assembly (COX) and mitochondrial respiration (PubMed:11302691, PubMed:20959514). Binding to sphingoid 1-phosphate (SPP) modulates its regulator activity (PubMed:11302691, PubMed:20959514). Has a key role of mitophagy receptor involved in targeting mitochondria for autophagic degradation (PubMed:28017329). Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6 (PubMed:31522117). {ECO:0000250|UniProtKB:O35129, ECO:0000269|PubMed:11302691, ECO:0000269|PubMed:20959514, ECO:0000269|PubMed:28017329, ECO:0000269|PubMed:31522117, ECO:0000305|PubMed:25904163}.; FUNCTION: In the nucleus, serves as transcriptional co-regulator (Probable). Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity (By similarity). {ECO:0000250|UniProtKB:O35129, ECO:0000305|PubMed:25904163}.; FUNCTION: In the plasma membrane, is involved in IGFBP6-induced cell migration (PubMed:24003225). Cooperates with CD86 to mediate CD86-signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates. Upon CD40 engagement, required to activate NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity). {ECO:0000250|UniProtKB:O35129, ECO:0000269|PubMed:24003225}.; FUNCTION: (Microbial infection) Involved in human enterovirus 71/EV-71 infection by enhancing the autophagy mechanism during the infection. {ECO:0000269|PubMed:32276428}. |
| Q9BUJ2 | HNRNPUL1 | S512 | ochoa | Heterogeneous nuclear ribonucleoprotein U-like protein 1 (Adenovirus early region 1B-associated protein 5) (E1B-55 kDa-associated protein 5) (E1B-AP5) | Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation. Also plays a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro. {ECO:0000269|PubMed:12489984, ECO:0000269|PubMed:9733834}. |
| Q9BYW2 | SETD2 | S1165 | ochoa | Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) | Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}. |
| Q9H0M0 | WWP1 | S26 | ochoa | NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 2.3.2.26) (Atrophin-1-interacting protein 5) (AIP5) (HECT-type E3 ubiquitin transferase WWP1) (TGIF-interacting ubiquitin ligase 1) (Tiul1) (WW domain-containing protein 1) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF. Activates the Hippo signaling pathway in response to cell contact inhibition and recruitment to the Crumbs complex at the cell membrane (PubMed:34404733). Monoubiquitinates AMOTL2 which facilitates its interaction with and activation of LATS2 (PubMed:34404733). LATS2 then phosphorylates YAP1, excluding it from the nucleus and therefore ultimately represses YAP1-driven transcription of target genes (PubMed:34404733). {ECO:0000269|PubMed:12535537, ECO:0000269|PubMed:15221015, ECO:0000269|PubMed:15359284, ECO:0000269|PubMed:34404733}. |
| Q9H0W5 | CCDC8 | S100 | ochoa | Coiled-coil domain-containing protein 8 | Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695, PubMed:24793696). Required for localization of CUL7 to the centrosome (PubMed:24793695). {ECO:0000269|PubMed:24793695, ECO:0000269|PubMed:24793696}. |
| Q9H4G0 | EPB41L1 | S69 | ochoa | Band 4.1-like protein 1 (Erythrocyte membrane protein band 4.1-like 1) (Neuronal protein 4.1) (4.1N) | May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases. |
| Q9H792 | PEAK1 | S1005 | ochoa | Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269) | Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:20534451, PubMed:23105102, PubMed:35687021). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654). {ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:23105102, ECO:0000269|PubMed:23846654, ECO:0000269|PubMed:35687021}. |
| Q9H9J4 | USP42 | S612 | ochoa | Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.4.19.12) (Deubiquitinating enzyme 42) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) | Deubiquitinating enzyme which may play an important role during spermatogenesis. {ECO:0000250}. |
| Q9NQ66 | PLCB1 | S887 | psp | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (EC 3.1.4.11) (PLC-154) (Phosphoinositide phospholipase C-beta-1) (Phospholipase C-I) (PLC-I) (Phospholipase C-beta-1) (PLC-beta-1) | Catalyzes the hydrolysis of 1-phosphatidylinositol 4,5-bisphosphate into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) and mediates intracellular signaling downstream of G protein-coupled receptors (PubMed:9188725). Regulates the function of the endothelial barrier. {ECO:0000250|UniProtKB:Q9Z1B3, ECO:0000269|PubMed:9188725}. |
| Q9NRJ4 | TULP4 | S1373 | ochoa | Tubby-related protein 4 (Tubby superfamily protein) (Tubby-like protein 4) | May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000250}. |
| Q9NTI5 | PDS5B | S1139 | ochoa | Sister chromatid cohesion protein PDS5 homolog B (Androgen-induced proliferation inhibitor) (Androgen-induced prostate proliferative shutoff-associated protein AS3) | Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells. {ECO:0000269|PubMed:10963680, ECO:0000269|PubMed:15855230, ECO:0000269|PubMed:19696148}. |
| Q9P0J1 | PDP1 | S292 | psp | [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial (PDP 1) (EC 3.1.3.43) (Protein phosphatase 2C) (Pyruvate dehydrogenase phosphatase catalytic subunit 1) (PDPC 1) | Mitochondrial enzyme that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (PDC), thereby stimulating the conversion of pyruvate into acetyl-CoA. {ECO:0000269|PubMed:15554715, ECO:0000305|PubMed:15855260}. |
| Q9P265 | DIP2B | S75 | ochoa | Disco-interacting protein 2 homolog B (DIP2 homolog B) | Negatively regulates axonal outgrowth and is essential for normal synaptic transmission. Not required for regulation of axon polarity. Promotes acetylation of alpha-tubulin. {ECO:0000250|UniProtKB:Q3UH60}. |
| Q9P2F8 | SIPA1L2 | S389 | ochoa | Signal-induced proliferation-associated 1-like protein 2 (SIPA1-like protein 2) | None |
| Q9UBC2 | EPS15L1 | S587 | ochoa | Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) | Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:9407958}. |
| Q9UIU6 | SIX4 | S249 | ochoa | Homeobox protein SIX4 (Sine oculis homeobox homolog 4) | Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a DNA sequence on these target genes and is involved in processes like cell differentiation, cell migration and cell survival. Transactivates gene expression by binding a 5'-[CAT]A[CT][CT][CTG]GA[GAT]-3' motif present in the Trex site and a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 site of the muscle-specific genes enhancer. Acts cooperatively with EYA proteins to transactivate their target genes through interaction and nuclear translocation of EYA protein. Acts synergistically with SIX1 to regulate target genes involved in formation of various organs, including muscle, kidney, gonad, ganglia, olfactory epithelium and cranial skeleton. Plays a role in several important steps of muscle development. Controls the genesis of hypaxial myogenic progenitors in the dermomyotome by transactivating PAX3 and the delamination and migration of the hypaxial precursors from the ventral lip to the limb buds through the transactivation of PAX3, MET and LBX1. Controls myoblast determination by transactivating MYF5, MYOD1 and MYF6. Controls somitic differentiation in myocyte through MYOG transactivation. Plays a role in synaptogenesis and sarcomere organization by participating in myofiber specialization during embryogenesis by activating fast muscle program in the primary myotome resulting in an up-regulation of fast muscle genes, including ATP2A1, MYL1 and TNNT3. Simultaneously, is also able to activate inhibitors of slow muscle genes, such as SOX6, HRASLS, and HDAC4, thereby restricting the activation of the slow muscle genes. During muscle regeneration, negatively regulates differentiation of muscle satellite cells through down-regulation of MYOG expression. During kidney development regulates the early stages of metanephros development and ureteric bud formation through regulation of GDNF, SALL1, PAX8 and PAX2 expression. Plays a role in gonad development by regulating both testis determination and size determination. In gonadal sex determination, transactivates ZFPM2 by binding a MEF3 consensus sequence, resulting in SRY up-regulation. In gonadal size determination, transactivates NR5A1 by binding a MEF3 consensus sequence resulting in gonadal precursor cell formation regulation. During olfactory development mediates the specification and patterning of olfactory placode through fibroblast growth factor and BMP4 signaling pathways and also regulates epithelial cell proliferation during placode formation. Promotes survival of sensory neurons during early trigeminal gangliogenesis. In the developing dorsal root ganglia, up-regulates SLC12A2 transcription. Regulates early thymus/parathyroid organogenesis through regulation of GCM2 and FOXN1 expression. Forms gustatory papillae during development of the tongue. Also plays a role during embryonic cranial skeleton morphogenesis. {ECO:0000250|UniProtKB:Q61321}. |
| Q9UP83 | COG5 | S197 | ochoa | Conserved oligomeric Golgi complex subunit 5 (COG complex subunit 5) (13S Golgi transport complex 90 kDa subunit) (GTC-90) (Component of oligomeric Golgi complex 5) (Golgi transport complex 1) | Required for normal Golgi function. {ECO:0000250|UniProtKB:Q9VJD3}. |
| Q9Y6R1 | SLC4A4 | S232 | ochoa|psp | Electrogenic sodium bicarbonate cotransporter 1 (Sodium bicarbonate cotransporter) (Na(+)/HCO3(-) cotransporter) (Solute carrier family 4 member 4) (kNBC1) | Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. {ECO:0000269|PubMed:10069984, ECO:0000269|PubMed:11744745, ECO:0000269|PubMed:12411514, ECO:0000269|PubMed:12730338, ECO:0000269|PubMed:12907161, ECO:0000269|PubMed:14567693, ECO:0000269|PubMed:15218065, ECO:0000269|PubMed:15713912, ECO:0000269|PubMed:15817634, ECO:0000269|PubMed:15930088, ECO:0000269|PubMed:16636648, ECO:0000269|PubMed:16769890, ECO:0000269|PubMed:17661077, ECO:0000269|PubMed:23324180, ECO:0000269|PubMed:23636456, ECO:0000269|PubMed:29500354, ECO:0000269|PubMed:9235899, ECO:0000269|PubMed:9651366}. |
| P06733 | ENO1 | S349 | Sugiyama | Alpha-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (C-myc promoter-binding protein) (Enolase 1) (MBP-1) (MPB-1) (Non-neural enolase) (NNE) (Phosphopyruvate hydratase) (Plasminogen-binding protein) | Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (PubMed:1369209, PubMed:29775581). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses (PubMed:10802057, PubMed:12666133, PubMed:2005901, PubMed:29775581). May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (PubMed:12666133). Stimulates immunoglobulin production (PubMed:1369209). {ECO:0000269|PubMed:10802057, ECO:0000269|PubMed:12666133, ECO:0000269|PubMed:1369209, ECO:0000269|PubMed:2005901, ECO:0000269|PubMed:29775581}.; FUNCTION: [Isoform MBP-1]: Binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor. {ECO:0000269|PubMed:10082554}. |
| Q6ULP2 | AFTPH | S328 | Sugiyama | Aftiphilin | Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025}. |
| Q27J81 | INF2 | S826 | Sugiyama | Inverted formin-2 (HBEBP2-binding protein C) | Severs actin filaments and accelerates their polymerization and depolymerization. {ECO:0000250}. |
| P24752 | ACAT1 | S69 | Sugiyama | Acetyl-CoA acetyltransferase, mitochondrial (EC 2.3.1.9) (Acetoacetyl-CoA thiolase) (T2) | This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (PubMed:1715688, PubMed:7728148, PubMed:9744475). Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms (PubMed:1715688, PubMed:7728148, PubMed:9744475). The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA (PubMed:17371050). Thereby, it plays a major role in ketone body metabolism (PubMed:1715688, PubMed:17371050, PubMed:7728148, PubMed:9744475). {ECO:0000269|PubMed:1715688, ECO:0000269|PubMed:17371050, ECO:0000269|PubMed:7728148, ECO:0000269|PubMed:9744475}. |
| P17948 | FLT1 | S1031 | Sugiyama | Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase FRT) (Tyrosine-protein kinase receptor FLT) (FLT) (Vascular permeability factor receptor) | Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. Acts as a positive regulator of postnatal retinal hyaloid vessel regression (By similarity). May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC and YES1, and may also phosphorylate CBL. Promotes phosphorylation of AKT1 at 'Ser-473'. Promotes phosphorylation of PTK2/FAK1 (PubMed:16685275). {ECO:0000250|UniProtKB:P35969, ECO:0000269|PubMed:11141500, ECO:0000269|PubMed:11312102, ECO:0000269|PubMed:11811792, ECO:0000269|PubMed:12796773, ECO:0000269|PubMed:14633857, ECO:0000269|PubMed:15735759, ECO:0000269|PubMed:16685275, ECO:0000269|PubMed:18079407, ECO:0000269|PubMed:18515749, ECO:0000269|PubMed:18583712, ECO:0000269|PubMed:18593464, ECO:0000269|PubMed:20512933, ECO:0000269|PubMed:20551949, ECO:0000269|PubMed:21752276, ECO:0000269|PubMed:7824266, ECO:0000269|PubMed:8248162, ECO:0000269|PubMed:8605350, ECO:0000269|PubMed:9299537, ECO:0000269|Ref.11}.; FUNCTION: [Isoform 1]: Phosphorylates PLCG. {ECO:0000269|PubMed:9299537}.; FUNCTION: [Isoform 2]: May function as decoy receptor for VEGFA. {ECO:0000269|PubMed:21752276}.; FUNCTION: [Isoform 3]: May function as decoy receptor for VEGFA. {ECO:0000269|PubMed:21752276}.; FUNCTION: [Isoform 4]: May function as decoy receptor for VEGFA. {ECO:0000269|PubMed:21752276}.; FUNCTION: [Isoform 7]: Has a truncated kinase domain; it increases phosphorylation of SRC at 'Tyr-418' by unknown means and promotes tumor cell invasion. {ECO:0000269|PubMed:20512933}. |
| P13797 | PLS3 | S540 | Sugiyama | Plastin-3 (T-fimbrin) (T-plastin) | Actin-bundling protein. |
| P35916 | FLT4 | S1046 | Sugiyama | Vascular endothelial growth factor receptor 3 (VEGFR-3) (EC 2.7.10.1) (Fms-like tyrosine kinase 4) (FLT-4) (Tyrosine-protein kinase receptor FLT4) | Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'. {ECO:0000269|PubMed:11532940, ECO:0000269|PubMed:15102829, ECO:0000269|PubMed:15474514, ECO:0000269|PubMed:16076871, ECO:0000269|PubMed:16452200, ECO:0000269|PubMed:17210781, ECO:0000269|PubMed:19610651, ECO:0000269|PubMed:19779139, ECO:0000269|PubMed:20224550, ECO:0000269|PubMed:20431062, ECO:0000269|PubMed:20445537, ECO:0000269|PubMed:21273538, ECO:0000269|PubMed:7675451, ECO:0000269|PubMed:8700872, ECO:0000269|PubMed:9435229}. |
| P13797 | PLS3 | S114 | Sugiyama | Plastin-3 (T-fimbrin) (T-plastin) | Actin-bundling protein. |
| Q9Y624 | F11R | S34 | iPTMNet | Junctional adhesion molecule A (JAM-A) (Junctional adhesion molecule 1) (JAM-1) (Platelet F11 receptor) (Platelet adhesion molecule 1) (PAM-1) (CD antigen CD321) | Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3 (PubMed:11489913). The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier (By similarity). Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration (PubMed:11812992). Involved in platelet activation (PubMed:10753840). {ECO:0000250|UniProtKB:O88792, ECO:0000269|PubMed:10753840, ECO:0000269|PubMed:11489913, ECO:0000269|PubMed:11812992}.; FUNCTION: (Microbial infection) Acts as a receptor for Mammalian reovirus sigma-1. {ECO:0000269|PubMed:11239401}.; FUNCTION: (Microbial infection) Acts as a receptor for Human Rotavirus strain Wa. {ECO:0000269|PubMed:25481868}. |
| Q01082 | SPTBN1 | S1666 | Sugiyama | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
| Q13043 | STK4 | S75 | Sugiyama | Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)] | Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes. {ECO:0000250|UniProtKB:Q9JI11, ECO:0000269|PubMed:11278283, ECO:0000269|PubMed:11517310, ECO:0000269|PubMed:12757711, ECO:0000269|PubMed:15109305, ECO:0000269|PubMed:16510573, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:17932490, ECO:0000269|PubMed:18328708, ECO:0000269|PubMed:18986304, ECO:0000269|PubMed:19525978, ECO:0000269|PubMed:21212262, ECO:0000269|PubMed:21245099, ECO:0000269|PubMed:21512132, ECO:0000269|PubMed:8702870, ECO:0000269|PubMed:8816758}. |
| Q14191 | WRN | S1292 | GPS6|SIGNOR|ELM|iPTMNet|EPSD | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (DNA helicase, RecQ-like type 3) (RecQ protein-like 2) (Werner syndrome protein) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)] | Multifunctional enzyme that has magnesium and ATP-dependent 3'-5' DNA-helicase activity on partially duplex substrates (PubMed:9224595, PubMed:9288107, PubMed:9611231). Also has 3'->5' exonuclease activity towards double-stranded (ds)DNA with a 5'-overhang (PubMed:11863428). Has no nuclease activity towards single-stranded (ss)DNA or blunt-ended dsDNA (PubMed:11863428). Helicase activity is most efficient with (d)ATP, but (d)CTP will substitute with reduced efficiency; strand displacement is enhanced by single-strand binding-protein (heterotrimeric replication protein A complex, RPA1, RPA2, RPA3) (PubMed:9611231). Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A (By similarity). Plays a role in double-strand break repair after gamma-irradiation (PubMed:9224595, PubMed:9288107, PubMed:9611231). Unwinds some G-quadruplex DNA (d(CGG)n tracts); unwinding seems to occur in both 5'-3' and 3'-5' direction and requires a short single-stranded tail (PubMed:10212265). d(CGG)n tracts have a propensity to assemble into tetraplex structures; other G-rich substrates from a telomeric or IgG switch sequence are not unwound (PubMed:10212265). Depletion leads to chromosomal breaks and genome instability (PubMed:33199508). {ECO:0000250|UniProtKB:O09053, ECO:0000269|PubMed:10212265, ECO:0000269|PubMed:11863428, ECO:0000269|PubMed:17563354, ECO:0000269|PubMed:18596042, ECO:0000269|PubMed:19283071, ECO:0000269|PubMed:19652551, ECO:0000269|PubMed:21639834, ECO:0000269|PubMed:27063109, ECO:0000269|PubMed:33199508, ECO:0000269|PubMed:9224595, ECO:0000269|PubMed:9288107, ECO:0000269|PubMed:9611231}. |
| P09497 | CLTB | S206 | Sugiyama | Clathrin light chain B (Lcb) | Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. |
| P62913 | RPL11 | S51 | Sugiyama | Large ribosomal subunit protein uL5 (60S ribosomal protein L11) (CLL-associated antigen KW-12) | Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:19191325, PubMed:32669547). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (PubMed:19191325, PubMed:32669547). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (PubMed:19191325, PubMed:32669547). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:19191325, PubMed:32669547). As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs (PubMed:12962325, PubMed:19061985, PubMed:24120868). It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 (PubMed:24120868). Promotes nucleolar location of PML (By similarity). {ECO:0000250|UniProtKB:Q9CXW4, ECO:0000269|PubMed:12962325, ECO:0000269|PubMed:19061985, ECO:0000269|PubMed:19191325, ECO:0000269|PubMed:24120868, ECO:0000269|PubMed:32669547}. |
| Q14203 | DCTN1 | S967 | Sugiyama | Dynactin subunit 1 (150 kDa dynein-associated polypeptide) (DAP-150) (DP-150) (p135) (p150-glued) | Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule (PubMed:25185702). Can regulate microtubule stability by promoting microtubule formation, nucleation and polymerization and by inhibiting microtubule catastrophe in neurons. Inhibits microtubule catastrophe by binding both to microtubules and to tubulin, leading to enhanced microtubule stability along the axon (PubMed:23874158). Plays a role in metaphase spindle orientation (PubMed:22327364). Plays a role in centriole cohesion and subdistal appendage organization and function. Its recruitment to the centriole in a KIF3A-dependent manner is essential for the maintenance of centriole cohesion and the formation of subdistal appendage. Also required for microtubule anchoring at the mother centriole (PubMed:23386061). Plays a role in primary cilia formation (PubMed:25774020). {ECO:0000250|UniProtKB:A0A287B8J2, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23386061, ECO:0000269|PubMed:23874158, ECO:0000269|PubMed:25185702, ECO:0000269|PubMed:25774020}. |
| Q92878 | RAD50 | S878 | Sugiyama | DNA repair protein RAD50 (hRAD50) (EC 3.6.-.-) | Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:15064416, PubMed:21757780, PubMed:27889449, PubMed:28134932, PubMed:28867292, PubMed:9590181, PubMed:9651580, PubMed:9705271). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (PubMed:15064416, PubMed:21757780, PubMed:27889449, PubMed:28867292, PubMed:9590181, PubMed:9651580, PubMed:9705271). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (PubMed:15064416, PubMed:27889449, PubMed:28867292, PubMed:9590181, PubMed:9651580, PubMed:9705271). The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination (PubMed:11741547, PubMed:9590181, PubMed:9651580, PubMed:9705271). Within the complex, RAD50 is both required to bind DNA ends and hold them in close proximity and regulate the activity of MRE11 (PubMed:11741547, PubMed:12805565, PubMed:28134932). RAD50 provides an ATP-dependent control of MRE11 by positioning DNA ends into the MRE11 active site: ATP-binding induces a large structural change from an open form with accessible MRE11 nuclease sites into a closed form (By similarity). The MRN complex is also required for DNA damage signaling via activation of the ATM and ATR kinases: the nuclease activity of MRE11 is not required to activate ATM and ATR (PubMed:15064416, PubMed:15790808, PubMed:16622404). The MRN complex is also required for the processing of R-loops (PubMed:31537797). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888). {ECO:0000250|UniProtKB:Q9X1X1, ECO:0000269|PubMed:10888888, ECO:0000269|PubMed:11741547, ECO:0000269|PubMed:12805565, ECO:0000269|PubMed:15064416, ECO:0000269|PubMed:15790808, ECO:0000269|PubMed:16622404, ECO:0000269|PubMed:21757780, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:28134932, ECO:0000269|PubMed:28867292, ECO:0000269|PubMed:31537797, ECO:0000269|PubMed:9590181, ECO:0000269|PubMed:9651580, ECO:0000269|PubMed:9705271}. |
| Q9Y6E0 | STK24 | S391 | Sugiyama | Serine/threonine-protein kinase 24 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 3) (MST-3) (STE20-like kinase MST3) [Cleaved into: Serine/threonine-protein kinase 24 36 kDa subunit (Mammalian STE20-like protein kinase 3 N-terminal) (MST3/N); Serine/threonine-protein kinase 24 12 kDa subunit (Mammalian STE20-like protein kinase 3 C-terminal) (MST3/C)] | Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. In association with STK26 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006). Also regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000269|PubMed:16314523, ECO:0000269|PubMed:17046825, ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:19604147, ECO:0000269|PubMed:19782762, ECO:0000269|PubMed:19855390, ECO:0000269|PubMed:27807006}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-3371568 | Attenuation phase | 1.110223e-16 | 15.955 |
| R-HSA-3371571 | HSF1-dependent transactivation | 1.110223e-16 | 15.955 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 1.110223e-16 | 15.955 |
| R-HSA-3371556 | Cellular response to heat stress | 1.110223e-16 | 15.955 |
| R-HSA-3371511 | HSF1 activation | 1.110223e-16 | 15.955 |
| R-HSA-2262752 | Cellular responses to stress | 2.687117e-11 | 10.571 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.607096e-10 | 9.794 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 1.056876e-06 | 5.976 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 2.142575e-06 | 5.669 |
| R-HSA-9833482 | PKR-mediated signaling | 3.021467e-05 | 4.520 |
| R-HSA-9764561 | Regulation of CDH1 Function | 5.028439e-05 | 4.299 |
| R-HSA-373760 | L1CAM interactions | 4.966078e-05 | 4.304 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 5.818272e-05 | 4.235 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 1.437227e-04 | 3.842 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 1.393106e-04 | 3.856 |
| R-HSA-196025 | Formation of annular gap junctions | 1.899252e-04 | 3.721 |
| R-HSA-190828 | Gap junction trafficking | 1.794172e-04 | 3.746 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 1.886956e-04 | 3.724 |
| R-HSA-190873 | Gap junction degradation | 2.448098e-04 | 3.611 |
| R-HSA-157858 | Gap junction trafficking and regulation | 2.730244e-04 | 3.564 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 4.272784e-04 | 3.369 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 4.679600e-04 | 3.330 |
| R-HSA-422475 | Axon guidance | 4.979869e-04 | 3.303 |
| R-HSA-9675108 | Nervous system development | 9.439851e-04 | 3.025 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 1.146588e-03 | 2.941 |
| R-HSA-1500931 | Cell-Cell communication | 1.909034e-03 | 2.719 |
| R-HSA-437239 | Recycling pathway of L1 | 2.240147e-03 | 2.650 |
| R-HSA-195399 | VEGF binds to VEGFR leading to receptor dimerization | 2.907521e-03 | 2.536 |
| R-HSA-194313 | VEGF ligand-receptor interactions | 2.907521e-03 | 2.536 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 3.631231e-03 | 2.440 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 3.838393e-03 | 2.416 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 4.310343e-03 | 2.365 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 4.381695e-03 | 2.358 |
| R-HSA-68877 | Mitotic Prometaphase | 5.218620e-03 | 2.282 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 7.435638e-03 | 2.129 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 6.002897e-03 | 2.222 |
| R-HSA-390522 | Striated Muscle Contraction | 7.424932e-03 | 2.129 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 6.915151e-03 | 2.160 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 6.915151e-03 | 2.160 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 7.295877e-03 | 2.137 |
| R-HSA-199991 | Membrane Trafficking | 6.457899e-03 | 2.190 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 6.976181e-03 | 2.156 |
| R-HSA-9734767 | Developmental Cell Lineages | 7.182104e-03 | 2.144 |
| R-HSA-9700206 | Signaling by ALK in cancer | 6.683238e-03 | 2.175 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 6.683238e-03 | 2.175 |
| R-HSA-913531 | Interferon Signaling | 6.881370e-03 | 2.162 |
| R-HSA-421270 | Cell-cell junction organization | 5.597334e-03 | 2.252 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 8.312556e-03 | 2.080 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 8.671019e-03 | 2.062 |
| R-HSA-9013694 | Signaling by NOTCH4 | 9.039449e-03 | 2.044 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 9.551873e-03 | 2.020 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 9.551873e-03 | 2.020 |
| R-HSA-446728 | Cell junction organization | 9.614674e-03 | 2.017 |
| R-HSA-9659379 | Sensory processing of sound | 1.103474e-02 | 1.957 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 1.217142e-02 | 1.915 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 1.217142e-02 | 1.915 |
| R-HSA-194138 | Signaling by VEGF | 1.281056e-02 | 1.892 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 1.528682e-02 | 1.816 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 1.528682e-02 | 1.816 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 1.478130e-02 | 1.830 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 1.582885e-02 | 1.801 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 1.736137e-02 | 1.760 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 1.692200e-02 | 1.772 |
| R-HSA-68886 | M Phase | 1.859593e-02 | 1.731 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 1.843849e-02 | 1.734 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 1.736137e-02 | 1.760 |
| R-HSA-2682334 | EPH-Ephrin signaling | 1.864845e-02 | 1.729 |
| R-HSA-381070 | IRE1alpha activates chaperones | 1.806132e-02 | 1.743 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 2.003464e-02 | 1.698 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 2.010824e-02 | 1.697 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 2.362878e-02 | 1.627 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 2.183878e-02 | 1.661 |
| R-HSA-445355 | Smooth Muscle Contraction | 2.270770e-02 | 1.644 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 2.168799e-02 | 1.664 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 2.254832e-02 | 1.647 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 2.404917e-02 | 1.619 |
| R-HSA-5619054 | Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalit... | 2.900917e-02 | 1.537 |
| R-HSA-9915355 | Beta-ketothiolase deficiency | 2.900917e-02 | 1.537 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 2.547694e-02 | 1.594 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.547694e-02 | 1.594 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 2.547694e-02 | 1.594 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.547694e-02 | 1.594 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 2.547694e-02 | 1.594 |
| R-HSA-9636667 | Manipulation of host energy metabolism | 2.900917e-02 | 1.537 |
| R-HSA-397014 | Muscle contraction | 2.769297e-02 | 1.558 |
| R-HSA-418990 | Adherens junctions interactions | 3.080229e-02 | 1.511 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 3.127259e-02 | 1.505 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 3.338570e-02 | 1.476 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 3.338570e-02 | 1.476 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 3.342560e-02 | 1.476 |
| R-HSA-5653656 | Vesicle-mediated transport | 3.426858e-02 | 1.465 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 3.554555e-02 | 1.449 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 3.771620e-02 | 1.423 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 3.701616e-02 | 1.432 |
| R-HSA-194306 | Neurophilin interactions with VEGF and VEGFR | 3.849183e-02 | 1.415 |
| R-HSA-420029 | Tight junction interactions | 3.771620e-02 | 1.423 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 4.220488e-02 | 1.375 |
| R-HSA-9673766 | Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | 4.788247e-02 | 1.320 |
| R-HSA-1251932 | PLCG1 events in ERBB2 signaling | 5.718197e-02 | 1.243 |
| R-HSA-5638302 | Signaling by Overexpressed Wild-Type EGFR in Cancer | 7.551106e-02 | 1.122 |
| R-HSA-5638303 | Inhibition of Signaling by Overexpressed EGFR | 7.551106e-02 | 1.122 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 8.454239e-02 | 1.073 |
| R-HSA-212718 | EGFR interacts with phospholipase C-gamma | 1.023429e-01 | 0.990 |
| R-HSA-9613354 | Lipophagy | 1.111137e-01 | 0.954 |
| R-HSA-9700645 | ALK mutants bind TKIs | 1.111137e-01 | 0.954 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 1.197994e-01 | 0.922 |
| R-HSA-416550 | Sema4D mediated inhibition of cell attachment and migration | 1.369185e-01 | 0.864 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 1.369185e-01 | 0.864 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 1.453536e-01 | 0.838 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 1.537067e-01 | 0.813 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 4.688243e-02 | 1.329 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 1.619788e-01 | 0.791 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 1.701704e-01 | 0.769 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 1.701704e-01 | 0.769 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 5.676868e-02 | 1.246 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 5.934465e-02 | 1.227 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 5.934465e-02 | 1.227 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 7.559917e-02 | 1.121 |
| R-HSA-418217 | G beta:gamma signalling through PLC beta | 2.021491e-01 | 0.694 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 7.843231e-02 | 1.106 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 2.176762e-01 | 0.662 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 4.623785e-02 | 1.335 |
| R-HSA-380287 | Centrosome maturation | 4.906222e-02 | 1.309 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 5.959182e-02 | 1.225 |
| R-HSA-72649 | Translation initiation complex formation | 1.244021e-01 | 0.905 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 1.309412e-01 | 0.883 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 1.375580e-01 | 0.862 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 7.629903e-02 | 1.117 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 7.807250e-02 | 1.108 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 8.534498e-02 | 1.069 |
| R-HSA-192823 | Viral mRNA Translation | 1.027052e-01 | 0.988 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 1.129084e-01 | 0.947 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 1.891381e-01 | 0.723 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 1.942711e-01 | 0.712 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 1.942711e-01 | 0.712 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 2.176174e-01 | 0.662 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 2.021491e-01 | 0.694 |
| R-HSA-182971 | EGFR downregulation | 5.173992e-02 | 1.286 |
| R-HSA-177929 | Signaling by EGFR | 1.309412e-01 | 0.883 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 1.234809e-01 | 0.908 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 1.408938e-01 | 0.851 |
| R-HSA-180292 | GAB1 signalosome | 2.021491e-01 | 0.694 |
| R-HSA-156902 | Peptide chain elongation | 7.108848e-02 | 1.148 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 1.612511e-01 | 0.792 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 1.234809e-01 | 0.908 |
| R-HSA-9948299 | Ribosome-associated quality control | 1.958114e-01 | 0.708 |
| R-HSA-5693606 | DNA Double Strand Break Response | 1.681525e-01 | 0.774 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 8.720689e-02 | 1.059 |
| R-HSA-444473 | Formyl peptide receptors bind formyl peptides and many other ligands | 1.023429e-01 | 0.990 |
| R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 1.369185e-01 | 0.864 |
| R-HSA-179812 | GRB2 events in EGFR signaling | 1.453536e-01 | 0.838 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 5.676868e-02 | 1.246 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 7.003541e-02 | 1.155 |
| R-HSA-5674135 | MAP2K and MAPK activation | 8.419653e-02 | 1.075 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 1.720756e-01 | 0.764 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 5.934465e-02 | 1.227 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 4.486289e-02 | 1.348 |
| R-HSA-2428933 | SHC-related events triggered by IGF1R | 1.453536e-01 | 0.838 |
| R-HSA-8949664 | Processing of SMDT1 | 1.537067e-01 | 0.813 |
| R-HSA-72764 | Eukaryotic Translation Termination | 8.720689e-02 | 1.059 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 1.926710e-01 | 0.715 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 5.676868e-02 | 1.246 |
| R-HSA-9609690 | HCMV Early Events | 1.620222e-01 | 0.790 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 8.419653e-02 | 1.075 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 9.913719e-02 | 1.004 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 9.913719e-02 | 1.004 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 9.913719e-02 | 1.004 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 1.211634e-01 | 0.917 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 6.196031e-02 | 1.208 |
| R-HSA-167172 | Transcription of the HIV genome | 1.716222e-01 | 0.765 |
| R-HSA-5689603 | UCH proteinases | 1.997624e-01 | 0.699 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 1.681525e-01 | 0.774 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 1.197994e-01 | 0.922 |
| R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 1.197994e-01 | 0.922 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 1.537067e-01 | 0.813 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 6.196031e-02 | 1.208 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 1.863159e-01 | 0.730 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 6.730668e-02 | 1.172 |
| R-HSA-500657 | Presynaptic function of Kainate receptors | 2.021491e-01 | 0.694 |
| R-HSA-5620924 | Intraflagellar transport | 1.053077e-01 | 0.978 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 8.720689e-02 | 1.059 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 2.021491e-01 | 0.694 |
| R-HSA-6802949 | Signaling by RAS mutants | 9.913719e-02 | 1.004 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 7.986399e-02 | 1.098 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 1.942711e-01 | 0.712 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 2.176762e-01 | 0.662 |
| R-HSA-391251 | Protein folding | 7.986399e-02 | 1.098 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 1.023429e-01 | 0.990 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 1.782826e-01 | 0.749 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 7.279989e-02 | 1.138 |
| R-HSA-6811438 | Intra-Golgi traffic | 8.419653e-02 | 1.075 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 9.913719e-02 | 1.004 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 8.742912e-02 | 1.058 |
| R-HSA-6798695 | Neutrophil degranulation | 9.988503e-02 | 1.000 |
| R-HSA-2467813 | Separation of Sister Chromatids | 1.053281e-01 | 0.977 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 2.083367e-01 | 0.681 |
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 1.197994e-01 | 0.922 |
| R-HSA-77108 | Utilization of Ketone Bodies | 1.284007e-01 | 0.891 |
| R-HSA-168330 | Viral RNP Complexes in the Host Cell Nucleus | 1.369185e-01 | 0.864 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 4.452061e-02 | 1.351 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 1.701704e-01 | 0.769 |
| R-HSA-434316 | Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion | 1.782826e-01 | 0.749 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 2.099505e-01 | 0.678 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 6.278005e-02 | 1.202 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 9.873267e-02 | 1.006 |
| R-HSA-5617833 | Cilium Assembly | 5.613333e-02 | 1.251 |
| R-HSA-373755 | Semaphorin interactions | 1.544043e-01 | 0.811 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 4.485696e-02 | 1.348 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 6.938879e-02 | 1.159 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 1.510028e-01 | 0.821 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 2.033043e-01 | 0.692 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 6.461465e-02 | 1.190 |
| R-HSA-399997 | Acetylcholine regulates insulin secretion | 1.863159e-01 | 0.730 |
| R-HSA-2408557 | Selenocysteine synthesis | 9.873267e-02 | 1.006 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 9.175448e-02 | 1.037 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 1.164815e-01 | 0.934 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 5.892659e-02 | 1.230 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 9.913719e-02 | 1.004 |
| R-HSA-9646399 | Aggrephagy | 7.843231e-02 | 1.106 |
| R-HSA-9927353 | Co-inhibition by BTLA | 6.639121e-02 | 1.178 |
| R-HSA-425381 | Bicarbonate transporters | 1.284007e-01 | 0.891 |
| R-HSA-77305 | Beta oxidation of palmitoyl-CoA to myristoyl-CoA | 1.453536e-01 | 0.838 |
| R-HSA-877312 | Regulation of IFNG signaling | 1.453536e-01 | 0.838 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 6.730668e-02 | 1.172 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 1.942711e-01 | 0.712 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 1.047152e-01 | 0.980 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 1.926710e-01 | 0.715 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 8.282587e-02 | 1.082 |
| R-HSA-416700 | Other semaphorin interactions | 1.701704e-01 | 0.769 |
| R-HSA-447041 | CHL1 interactions | 9.348603e-02 | 1.029 |
| R-HSA-8851805 | MET activates RAS signaling | 1.453536e-01 | 0.838 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 1.619788e-01 | 0.791 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 1.701704e-01 | 0.769 |
| R-HSA-2028269 | Signaling by Hippo | 1.942711e-01 | 0.712 |
| R-HSA-190861 | Gap junction assembly | 6.196031e-02 | 1.208 |
| R-HSA-3928664 | Ephrin signaling | 2.021491e-01 | 0.694 |
| R-HSA-8953854 | Metabolism of RNA | 2.207634e-01 | 0.656 |
| R-HSA-69275 | G2/M Transition | 1.437888e-01 | 0.842 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 1.111137e-01 | 0.954 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 1.619788e-01 | 0.791 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 1.473678e-01 | 0.832 |
| R-HSA-9663891 | Selective autophagy | 7.108848e-02 | 1.148 |
| R-HSA-6794361 | Neurexins and neuroligins | 1.179463e-01 | 0.928 |
| R-HSA-9675135 | Diseases of DNA repair | 9.913719e-02 | 1.004 |
| R-HSA-210990 | PECAM1 interactions | 1.284007e-01 | 0.891 |
| R-HSA-9828642 | Respiratory syncytial virus genome transcription | 1.619788e-01 | 0.791 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 5.173992e-02 | 1.286 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 5.676868e-02 | 1.246 |
| R-HSA-983189 | Kinesins | 1.442469e-01 | 0.841 |
| R-HSA-168255 | Influenza Infection | 4.655307e-02 | 1.332 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 1.047152e-01 | 0.980 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 1.473678e-01 | 0.832 |
| R-HSA-376176 | Signaling by ROBO receptors | 1.752633e-01 | 0.756 |
| R-HSA-1433559 | Regulation of KIT signaling | 1.619788e-01 | 0.791 |
| R-HSA-77111 | Synthesis of Ketone Bodies | 2.176762e-01 | 0.662 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 1.962126e-01 | 0.707 |
| R-HSA-68882 | Mitotic Anaphase | 2.027904e-01 | 0.693 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 2.048050e-01 | 0.689 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 1.885123e-01 | 0.725 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.249914e-01 | 0.903 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 4.884161e-02 | 1.311 |
| R-HSA-9683610 | Maturation of nucleoprotein | 1.537067e-01 | 0.813 |
| R-HSA-8876725 | Protein methylation | 1.701704e-01 | 0.769 |
| R-HSA-432142 | Platelet sensitization by LDL | 2.021491e-01 | 0.694 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 2.003451e-01 | 0.698 |
| R-HSA-1640170 | Cell Cycle | 5.620929e-02 | 1.250 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 2.099505e-01 | 0.678 |
| R-HSA-391160 | Signal regulatory protein family interactions | 1.619788e-01 | 0.791 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 8.742912e-02 | 1.058 |
| R-HSA-1632852 | Macroautophagy | 2.033043e-01 | 0.692 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 1.247525e-01 | 0.904 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 8.129840e-02 | 1.090 |
| R-HSA-445144 | Signal transduction by L1 | 2.176762e-01 | 0.662 |
| R-HSA-5683057 | MAPK family signaling cascades | 1.537743e-01 | 0.813 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 8.419653e-02 | 1.075 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 1.962126e-01 | 0.707 |
| R-HSA-373753 | Nephrin family interactions | 2.176762e-01 | 0.662 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 1.856144e-01 | 0.731 |
| R-HSA-9824446 | Viral Infection Pathways | 1.578619e-01 | 0.802 |
| R-HSA-9008059 | Interleukin-37 signaling | 4.928923e-02 | 1.307 |
| R-HSA-9694631 | Maturation of nucleoprotein | 2.099505e-01 | 0.678 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 1.821004e-01 | 0.740 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 1.053077e-01 | 0.978 |
| R-HSA-1236394 | Signaling by ERBB4 | 1.926710e-01 | 0.715 |
| R-HSA-1266738 | Developmental Biology | 2.155076e-01 | 0.667 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 9.307436e-02 | 1.031 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 1.947937e-01 | 0.710 |
| R-HSA-9694635 | Translation of Structural Proteins | 2.033199e-01 | 0.692 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 1.546286e-01 | 0.811 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 2.140339e-01 | 0.670 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 9.307436e-02 | 1.031 |
| R-HSA-2132295 | MHC class II antigen presentation | 1.525263e-01 | 0.817 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 1.343989e-01 | 0.872 |
| R-HSA-157118 | Signaling by NOTCH | 1.141194e-01 | 0.943 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 1.884592e-01 | 0.725 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 6.862085e-02 | 1.164 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 1.933294e-01 | 0.714 |
| R-HSA-1474244 | Extracellular matrix organization | 5.897132e-02 | 1.229 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 2.253267e-01 | 0.647 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 2.253267e-01 | 0.647 |
| R-HSA-1482925 | Acyl chain remodelling of PG | 2.253267e-01 | 0.647 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 2.283984e-01 | 0.641 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 2.320008e-01 | 0.635 |
| R-HSA-1500620 | Meiosis | 2.320008e-01 | 0.635 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 2.320008e-01 | 0.635 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 2.329029e-01 | 0.633 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 2.329029e-01 | 0.633 |
| R-HSA-72312 | rRNA processing | 2.356866e-01 | 0.628 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 2.364783e-01 | 0.626 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 2.392160e-01 | 0.621 |
| R-HSA-166208 | mTORC1-mediated signalling | 2.404055e-01 | 0.619 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 2.404055e-01 | 0.619 |
| R-HSA-975578 | Reactions specific to the complex N-glycan synthesis pathway | 2.404055e-01 | 0.619 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 2.404055e-01 | 0.619 |
| R-HSA-8964038 | LDL clearance | 2.404055e-01 | 0.619 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 2.426841e-01 | 0.615 |
| R-HSA-70268 | Pyruvate metabolism | 2.428280e-01 | 0.615 |
| R-HSA-438064 | Post NMDA receptor activation events | 2.428280e-01 | 0.615 |
| R-HSA-9612973 | Autophagy | 2.442699e-01 | 0.612 |
| R-HSA-162587 | HIV Life Cycle | 2.468765e-01 | 0.608 |
| R-HSA-400451 | Free fatty acids regulate insulin secretion | 2.478352e-01 | 0.606 |
| R-HSA-74182 | Ketone body metabolism | 2.478352e-01 | 0.606 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 2.478352e-01 | 0.606 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 2.478352e-01 | 0.606 |
| R-HSA-982772 | Growth hormone receptor signaling | 2.478352e-01 | 0.606 |
| R-HSA-112315 | Transmission across Chemical Synapses | 2.481436e-01 | 0.605 |
| R-HSA-9711097 | Cellular response to starvation | 2.494875e-01 | 0.603 |
| R-HSA-429947 | Deadenylation of mRNA | 2.551926e-01 | 0.593 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 2.551926e-01 | 0.593 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 2.624785e-01 | 0.581 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 2.624785e-01 | 0.581 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 2.624785e-01 | 0.581 |
| R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 2.624785e-01 | 0.581 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 2.645378e-01 | 0.578 |
| R-HSA-2408522 | Selenoamino acid metabolism | 2.652375e-01 | 0.576 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 2.695710e-01 | 0.569 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 2.696936e-01 | 0.569 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 2.696936e-01 | 0.569 |
| R-HSA-9865118 | Diseases of branched-chain amino acid catabolism | 2.696936e-01 | 0.569 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 2.717799e-01 | 0.566 |
| R-HSA-9609646 | HCMV Infection | 2.740822e-01 | 0.562 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 2.768386e-01 | 0.558 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 2.768386e-01 | 0.558 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 2.768386e-01 | 0.558 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 2.826384e-01 | 0.549 |
| R-HSA-167287 | HIV elongation arrest and recovery | 2.839141e-01 | 0.547 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 2.839141e-01 | 0.547 |
| R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 2.839141e-01 | 0.547 |
| R-HSA-5688426 | Deubiquitination | 2.849418e-01 | 0.545 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 2.862555e-01 | 0.543 |
| R-HSA-9615710 | Late endosomal microautophagy | 2.909208e-01 | 0.536 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 2.909208e-01 | 0.536 |
| R-HSA-204174 | Regulation of pyruvate dehydrogenase (PDH) complex | 2.909208e-01 | 0.536 |
| R-HSA-597592 | Post-translational protein modification | 2.913581e-01 | 0.536 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 2.943979e-01 | 0.531 |
| R-HSA-162582 | Signal Transduction | 2.946980e-01 | 0.531 |
| R-HSA-70171 | Glycolysis | 2.970946e-01 | 0.527 |
| R-HSA-5610787 | Hedgehog 'off' state | 2.970946e-01 | 0.527 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 2.978593e-01 | 0.526 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 2.978593e-01 | 0.526 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 2.978593e-01 | 0.526 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 2.978593e-01 | 0.526 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 2.978593e-01 | 0.526 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 3.043077e-01 | 0.517 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 3.047304e-01 | 0.516 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 3.047304e-01 | 0.516 |
| R-HSA-399719 | Trafficking of AMPA receptors | 3.047304e-01 | 0.516 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 3.115347e-01 | 0.506 |
| R-HSA-73894 | DNA Repair | 3.176478e-01 | 0.498 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 3.182728e-01 | 0.497 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 3.182728e-01 | 0.497 |
| R-HSA-397795 | G-protein beta:gamma signalling | 3.182728e-01 | 0.497 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 3.182728e-01 | 0.497 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 3.182728e-01 | 0.497 |
| R-HSA-159418 | Recycling of bile acids and salts | 3.182728e-01 | 0.497 |
| R-HSA-5696398 | Nucleotide Excision Repair | 3.186925e-01 | 0.497 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 3.249454e-01 | 0.488 |
| R-HSA-180746 | Nuclear import of Rev protein | 3.315531e-01 | 0.479 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 3.330079e-01 | 0.478 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 3.380965e-01 | 0.471 |
| R-HSA-1483249 | Inositol phosphate metabolism | 3.436893e-01 | 0.464 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 3.444331e-01 | 0.463 |
| R-HSA-9682385 | FLT3 signaling in disease | 3.445762e-01 | 0.463 |
| R-HSA-114604 | GPVI-mediated activation cascade | 3.445762e-01 | 0.463 |
| R-HSA-112316 | Neuronal System | 3.480790e-01 | 0.458 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 3.507804e-01 | 0.455 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 3.509929e-01 | 0.455 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 3.573472e-01 | 0.447 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 3.573472e-01 | 0.447 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 3.636397e-01 | 0.439 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 3.636397e-01 | 0.439 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 3.636397e-01 | 0.439 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 3.636397e-01 | 0.439 |
| R-HSA-201556 | Signaling by ALK | 3.636397e-01 | 0.439 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 3.636397e-01 | 0.439 |
| R-HSA-70326 | Glucose metabolism | 3.683915e-01 | 0.434 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 3.698709e-01 | 0.432 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 3.698709e-01 | 0.432 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 3.698709e-01 | 0.432 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 3.698709e-01 | 0.432 |
| R-HSA-167169 | HIV Transcription Elongation | 3.698709e-01 | 0.432 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 3.698709e-01 | 0.432 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 3.698709e-01 | 0.432 |
| R-HSA-9854311 | Maturation of TCA enzymes and regulation of TCA cycle | 3.698709e-01 | 0.432 |
| R-HSA-975576 | N-glycan antennae elongation in the medial/trans-Golgi | 3.698709e-01 | 0.432 |
| R-HSA-8982491 | Glycogen metabolism | 3.698709e-01 | 0.432 |
| R-HSA-451927 | Interleukin-2 family signaling | 3.698709e-01 | 0.432 |
| R-HSA-5693538 | Homology Directed Repair | 3.718921e-01 | 0.430 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 3.718921e-01 | 0.430 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 3.760415e-01 | 0.425 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 3.760415e-01 | 0.425 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 3.760415e-01 | 0.425 |
| R-HSA-9694548 | Maturation of spike protein | 3.760415e-01 | 0.425 |
| R-HSA-167161 | HIV Transcription Initiation | 3.821521e-01 | 0.418 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 3.821521e-01 | 0.418 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 3.821521e-01 | 0.418 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 3.821521e-01 | 0.418 |
| R-HSA-9683701 | Translation of Structural Proteins | 3.821521e-01 | 0.418 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 3.882032e-01 | 0.411 |
| R-HSA-165159 | MTOR signalling | 3.882032e-01 | 0.411 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 3.892763e-01 | 0.410 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 3.941954e-01 | 0.404 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 3.941954e-01 | 0.404 |
| R-HSA-1433557 | Signaling by SCF-KIT | 3.941954e-01 | 0.404 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 4.060054e-01 | 0.391 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 4.060054e-01 | 0.391 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 4.060054e-01 | 0.391 |
| R-HSA-77286 | mitochondrial fatty acid beta-oxidation of saturated fatty acids | 4.060054e-01 | 0.391 |
| R-HSA-69481 | G2/M Checkpoints | 4.064472e-01 | 0.391 |
| R-HSA-75153 | Apoptotic execution phase | 4.118243e-01 | 0.385 |
| R-HSA-5663205 | Infectious disease | 4.152959e-01 | 0.382 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 4.166392e-01 | 0.380 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 4.175866e-01 | 0.379 |
| R-HSA-1474165 | Reproduction | 4.200172e-01 | 0.377 |
| R-HSA-8951664 | Neddylation | 4.217502e-01 | 0.375 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 4.232927e-01 | 0.373 |
| R-HSA-70263 | Gluconeogenesis | 4.232927e-01 | 0.373 |
| R-HSA-392499 | Metabolism of proteins | 4.319716e-01 | 0.365 |
| R-HSA-162906 | HIV Infection | 4.372754e-01 | 0.359 |
| R-HSA-912446 | Meiotic recombination | 4.400801e-01 | 0.356 |
| R-HSA-70895 | Branched-chain amino acid catabolism | 4.400801e-01 | 0.356 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 4.433799e-01 | 0.353 |
| R-HSA-72187 | mRNA 3'-end processing | 4.455672e-01 | 0.351 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 4.455672e-01 | 0.351 |
| R-HSA-5358351 | Signaling by Hedgehog | 4.499603e-01 | 0.347 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 4.510009e-01 | 0.346 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 4.510009e-01 | 0.346 |
| R-HSA-1221632 | Meiotic synapsis | 4.510009e-01 | 0.346 |
| R-HSA-72766 | Translation | 4.528755e-01 | 0.344 |
| R-HSA-3247509 | Chromatin modifying enzymes | 4.551904e-01 | 0.342 |
| R-HSA-9664407 | Parasite infection | 4.564970e-01 | 0.341 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 4.564970e-01 | 0.341 |
| R-HSA-9664417 | Leishmania phagocytosis | 4.564970e-01 | 0.341 |
| R-HSA-9753281 | Paracetamol ADME | 4.617101e-01 | 0.336 |
| R-HSA-9012852 | Signaling by NOTCH3 | 4.617101e-01 | 0.336 |
| R-HSA-8939211 | ESR-mediated signaling | 4.627971e-01 | 0.335 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 4.662185e-01 | 0.331 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 4.669866e-01 | 0.331 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 4.722117e-01 | 0.326 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 4.737347e-01 | 0.324 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 4.825097e-01 | 0.316 |
| R-HSA-194441 | Metabolism of non-coding RNA | 4.825097e-01 | 0.316 |
| R-HSA-191859 | snRNP Assembly | 4.825097e-01 | 0.316 |
| R-HSA-180786 | Extension of Telomeres | 4.825097e-01 | 0.316 |
| R-HSA-69242 | S Phase | 4.853515e-01 | 0.314 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 4.875835e-01 | 0.312 |
| R-HSA-1227986 | Signaling by ERBB2 | 4.875835e-01 | 0.312 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 4.875835e-01 | 0.312 |
| R-HSA-156590 | Glutathione conjugation | 4.875835e-01 | 0.312 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 4.906688e-01 | 0.309 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 4.926080e-01 | 0.307 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 4.926080e-01 | 0.307 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 4.926080e-01 | 0.307 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 4.926080e-01 | 0.307 |
| R-HSA-112043 | PLC beta mediated events | 4.926080e-01 | 0.307 |
| R-HSA-4839726 | Chromatin organization | 4.927514e-01 | 0.307 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 4.975834e-01 | 0.303 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 4.975834e-01 | 0.303 |
| R-HSA-6784531 | tRNA processing in the nucleus | 4.975834e-01 | 0.303 |
| R-HSA-446652 | Interleukin-1 family signaling | 4.978705e-01 | 0.303 |
| R-HSA-8848021 | Signaling by PTK6 | 5.025104e-01 | 0.299 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 5.025104e-01 | 0.299 |
| R-HSA-2428924 | IGF1R signaling cascade | 5.073894e-01 | 0.295 |
| R-HSA-5690714 | CD22 mediated BCR regulation | 5.073894e-01 | 0.295 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 5.122208e-01 | 0.291 |
| R-HSA-112040 | G-protein mediated events | 5.217429e-01 | 0.283 |
| R-HSA-196807 | Nicotinate metabolism | 5.217429e-01 | 0.283 |
| R-HSA-9006936 | Signaling by TGFB family members | 5.223223e-01 | 0.282 |
| R-HSA-5633007 | Regulation of TP53 Activity | 5.223223e-01 | 0.282 |
| R-HSA-416476 | G alpha (q) signalling events | 5.290119e-01 | 0.277 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 5.356807e-01 | 0.271 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 5.402363e-01 | 0.267 |
| R-HSA-5619102 | SLC transporter disorders | 5.430594e-01 | 0.265 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 5.447476e-01 | 0.264 |
| R-HSA-4086398 | Ca2+ pathway | 5.492148e-01 | 0.260 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 5.618781e-01 | 0.250 |
| R-HSA-5689880 | Ub-specific processing proteases | 5.631685e-01 | 0.249 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 5.709060e-01 | 0.243 |
| R-HSA-4086400 | PCP/CE pathway | 5.709060e-01 | 0.243 |
| R-HSA-191273 | Cholesterol biosynthesis | 5.709060e-01 | 0.243 |
| R-HSA-216083 | Integrin cell surface interactions | 5.709060e-01 | 0.243 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 5.792892e-01 | 0.237 |
| R-HSA-6806834 | Signaling by MET | 5.792892e-01 | 0.237 |
| R-HSA-2559583 | Cellular Senescence | 5.826411e-01 | 0.235 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 5.991676e-01 | 0.222 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 5.995418e-01 | 0.222 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 6.073689e-01 | 0.217 |
| R-HSA-449147 | Signaling by Interleukins | 6.111825e-01 | 0.214 |
| R-HSA-1643685 | Disease | 6.150523e-01 | 0.211 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 6.196621e-01 | 0.208 |
| R-HSA-112310 | Neurotransmitter release cycle | 6.225700e-01 | 0.206 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 6.335856e-01 | 0.198 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 6.371861e-01 | 0.196 |
| R-HSA-9837999 | Mitochondrial protein degradation | 6.407513e-01 | 0.193 |
| R-HSA-77289 | Mitochondrial Fatty Acid Beta-Oxidation | 6.442818e-01 | 0.191 |
| R-HSA-72172 | mRNA Splicing | 6.469527e-01 | 0.189 |
| R-HSA-168256 | Immune System | 6.482150e-01 | 0.188 |
| R-HSA-157579 | Telomere Maintenance | 6.546676e-01 | 0.184 |
| R-HSA-422356 | Regulation of insulin secretion | 6.580621e-01 | 0.182 |
| R-HSA-3214847 | HATs acetylate histones | 6.614235e-01 | 0.180 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 6.713119e-01 | 0.173 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 6.713119e-01 | 0.173 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 6.777442e-01 | 0.169 |
| R-HSA-111885 | Opioid Signalling | 6.777442e-01 | 0.169 |
| R-HSA-168249 | Innate Immune System | 6.809707e-01 | 0.167 |
| R-HSA-418346 | Platelet homeostasis | 6.871588e-01 | 0.163 |
| R-HSA-211000 | Gene Silencing by RNA | 6.902359e-01 | 0.161 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 6.918322e-01 | 0.160 |
| R-HSA-2672351 | Stimuli-sensing channels | 6.932829e-01 | 0.159 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 6.992878e-01 | 0.155 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 7.011193e-01 | 0.154 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 7.109494e-01 | 0.148 |
| R-HSA-909733 | Interferon alpha/beta signaling | 7.193997e-01 | 0.143 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 7.195914e-01 | 0.143 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 7.277229e-01 | 0.138 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 7.302860e-01 | 0.137 |
| R-HSA-68875 | Mitotic Prophase | 7.329414e-01 | 0.135 |
| R-HSA-73886 | Chromosome Maintenance | 7.355707e-01 | 0.133 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 7.355707e-01 | 0.133 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 7.389872e-01 | 0.131 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 7.407526e-01 | 0.130 |
| R-HSA-162909 | Host Interactions of HIV factors | 7.433055e-01 | 0.129 |
| R-HSA-114608 | Platelet degranulation | 7.532699e-01 | 0.123 |
| R-HSA-69620 | Cell Cycle Checkpoints | 7.589977e-01 | 0.120 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 7.697914e-01 | 0.114 |
| R-HSA-163685 | Integration of energy metabolism | 7.787337e-01 | 0.109 |
| R-HSA-6807070 | PTEN Regulation | 7.852131e-01 | 0.105 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 7.857437e-01 | 0.105 |
| R-HSA-9824443 | Parasitic Infection Pathways | 7.966075e-01 | 0.099 |
| R-HSA-9658195 | Leishmania infection | 7.966075e-01 | 0.099 |
| R-HSA-109582 | Hemostasis | 8.063293e-01 | 0.093 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 8.092988e-01 | 0.092 |
| R-HSA-9679506 | SARS-CoV Infections | 8.199751e-01 | 0.086 |
| R-HSA-195721 | Signaling by WNT | 8.209965e-01 | 0.086 |
| R-HSA-9610379 | HCMV Late Events | 8.220886e-01 | 0.085 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 8.238448e-01 | 0.084 |
| R-HSA-877300 | Interferon gamma signaling | 8.255837e-01 | 0.083 |
| R-HSA-1280218 | Adaptive Immune System | 8.282839e-01 | 0.082 |
| R-HSA-109581 | Apoptosis | 8.306988e-01 | 0.081 |
| R-HSA-72306 | tRNA processing | 8.451666e-01 | 0.073 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 8.487721e-01 | 0.071 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 8.526663e-01 | 0.069 |
| R-HSA-8957322 | Metabolism of steroids | 8.532724e-01 | 0.069 |
| R-HSA-611105 | Respiratory electron transport | 8.569917e-01 | 0.067 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 8.585195e-01 | 0.066 |
| R-HSA-375276 | Peptide ligand-binding receptors | 8.679189e-01 | 0.062 |
| R-HSA-983712 | Ion channel transport | 8.717992e-01 | 0.060 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 8.763894e-01 | 0.057 |
| R-HSA-389948 | Co-inhibition by PD-1 | 8.850821e-01 | 0.053 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 8.884611e-01 | 0.051 |
| R-HSA-5357801 | Programmed Cell Death | 8.917413e-01 | 0.050 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 9.000274e-01 | 0.046 |
| R-HSA-9748784 | Drug ADME | 9.048829e-01 | 0.043 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 9.121688e-01 | 0.040 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.156010e-01 | 0.038 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 9.228439e-01 | 0.035 |
| R-HSA-418594 | G alpha (i) signalling events | 9.246728e-01 | 0.034 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 9.348813e-01 | 0.029 |
| R-HSA-9711123 | Cellular response to chemical stress | 9.422357e-01 | 0.026 |
| R-HSA-1483257 | Phospholipid metabolism | 9.559028e-01 | 0.020 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 9.666874e-01 | 0.015 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.779269e-01 | 0.010 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.831772e-01 | 0.007 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.838414e-01 | 0.007 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.843223e-01 | 0.007 |
| R-HSA-388396 | GPCR downstream signalling | 9.856834e-01 | 0.006 |
| R-HSA-8978868 | Fatty acid metabolism | 9.858251e-01 | 0.006 |
| R-HSA-5668914 | Diseases of metabolism | 9.884146e-01 | 0.005 |
| R-HSA-73857 | RNA Polymerase II Transcription | 9.896047e-01 | 0.005 |
| R-HSA-382551 | Transport of small molecules | 9.900614e-01 | 0.004 |
| R-HSA-74160 | Gene expression (Transcription) | 9.901390e-01 | 0.004 |
| R-HSA-372790 | Signaling by GPCR | 9.926987e-01 | 0.003 |
| R-HSA-9709957 | Sensory Perception | 9.953228e-01 | 0.002 |
| R-HSA-211859 | Biological oxidations | 9.956164e-01 | 0.002 |
| R-HSA-212436 | Generic Transcription Pathway | 9.958022e-01 | 0.002 |
| R-HSA-500792 | GPCR ligand binding | 9.977606e-01 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 9.993412e-01 | 0.000 |
| R-HSA-9752946 | Expression and translocation of olfactory receptors | 9.997213e-01 | 0.000 |
| R-HSA-381753 | Olfactory Signaling Pathway | 9.998705e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999846e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.844 | 0.103 | 2 | 0.737 |
CDC7 |
0.837 | 0.096 | 1 | 0.805 |
ERK5 |
0.833 | 0.152 | 1 | 0.806 |
PIM3 |
0.833 | 0.063 | -3 | 0.778 |
CLK3 |
0.832 | 0.124 | 1 | 0.810 |
PRPK |
0.831 | -0.068 | -1 | 0.801 |
MOS |
0.831 | 0.046 | 1 | 0.829 |
PRKD1 |
0.831 | 0.078 | -3 | 0.767 |
CDKL5 |
0.829 | 0.123 | -3 | 0.725 |
CDKL1 |
0.828 | 0.057 | -3 | 0.734 |
CAMK1B |
0.828 | 0.003 | -3 | 0.827 |
PRKD2 |
0.828 | 0.082 | -3 | 0.729 |
NLK |
0.827 | 0.020 | 1 | 0.759 |
PIM1 |
0.826 | 0.074 | -3 | 0.734 |
CHAK2 |
0.825 | 0.077 | -1 | 0.790 |
ATR |
0.825 | -0.006 | 1 | 0.764 |
RSK2 |
0.825 | 0.061 | -3 | 0.716 |
BMPR2 |
0.824 | -0.128 | -2 | 0.855 |
ULK2 |
0.824 | -0.089 | 2 | 0.669 |
PDHK4 |
0.824 | -0.182 | 1 | 0.779 |
DSTYK |
0.824 | -0.028 | 2 | 0.738 |
RIPK3 |
0.824 | 0.011 | 3 | 0.817 |
PAK6 |
0.823 | 0.255 | -2 | 0.689 |
CAMK2G |
0.823 | -0.065 | 2 | 0.661 |
TBK1 |
0.823 | -0.043 | 1 | 0.649 |
WNK1 |
0.822 | 0.031 | -2 | 0.850 |
RAF1 |
0.822 | -0.110 | 1 | 0.770 |
TSSK2 |
0.822 | 0.033 | -5 | 0.835 |
NDR2 |
0.822 | 0.020 | -3 | 0.795 |
MAPKAPK3 |
0.822 | 0.033 | -3 | 0.733 |
ICK |
0.821 | 0.091 | -3 | 0.774 |
NIK |
0.821 | -0.024 | -3 | 0.851 |
TSSK1 |
0.820 | 0.061 | -3 | 0.846 |
CAMLCK |
0.820 | -0.012 | -2 | 0.820 |
IKKE |
0.819 | -0.059 | 1 | 0.651 |
GCN2 |
0.819 | -0.143 | 2 | 0.664 |
MLK1 |
0.819 | -0.053 | 2 | 0.661 |
P90RSK |
0.819 | 0.008 | -3 | 0.707 |
AMPKA1 |
0.819 | 0.042 | -3 | 0.826 |
PDHK1 |
0.819 | -0.172 | 1 | 0.778 |
IKKB |
0.819 | -0.102 | -2 | 0.743 |
CAMK2D |
0.818 | -0.013 | -3 | 0.801 |
SKMLCK |
0.818 | -0.003 | -2 | 0.811 |
CDK8 |
0.818 | 0.061 | 1 | 0.617 |
MLK2 |
0.817 | 0.017 | 2 | 0.700 |
GRK5 |
0.817 | -0.052 | -3 | 0.833 |
PKN3 |
0.817 | -0.042 | -3 | 0.781 |
DAPK2 |
0.817 | -0.038 | -3 | 0.826 |
GRK6 |
0.817 | 0.017 | 1 | 0.780 |
HIPK4 |
0.817 | 0.047 | 1 | 0.758 |
NDR1 |
0.817 | 0.003 | -3 | 0.794 |
NEK6 |
0.817 | -0.039 | -2 | 0.829 |
PKCD |
0.816 | 0.004 | 2 | 0.643 |
P70S6KB |
0.816 | 0.022 | -3 | 0.755 |
MAPKAPK2 |
0.816 | 0.031 | -3 | 0.678 |
NEK9 |
0.816 | -0.043 | 2 | 0.718 |
MARK4 |
0.816 | -0.025 | 4 | 0.757 |
NEK7 |
0.816 | -0.092 | -3 | 0.795 |
NUAK2 |
0.815 | -0.024 | -3 | 0.811 |
MTOR |
0.815 | -0.146 | 1 | 0.705 |
GRK1 |
0.814 | 0.036 | -2 | 0.705 |
PKR |
0.814 | 0.038 | 1 | 0.805 |
FAM20C |
0.814 | 0.028 | 2 | 0.484 |
CAMK2B |
0.814 | 0.033 | 2 | 0.642 |
MST4 |
0.814 | -0.025 | 2 | 0.669 |
IKKA |
0.813 | -0.016 | -2 | 0.739 |
AMPKA2 |
0.813 | 0.043 | -3 | 0.792 |
LATS2 |
0.813 | -0.006 | -5 | 0.703 |
SRPK1 |
0.813 | 0.027 | -3 | 0.675 |
RSK3 |
0.813 | -0.002 | -3 | 0.708 |
PKN2 |
0.813 | -0.028 | -3 | 0.808 |
CHK1 |
0.813 | 0.041 | -3 | 0.813 |
HUNK |
0.812 | -0.077 | 2 | 0.684 |
WNK3 |
0.812 | -0.133 | 1 | 0.749 |
TGFBR2 |
0.812 | -0.062 | -2 | 0.725 |
MASTL |
0.812 | -0.156 | -2 | 0.805 |
CDK19 |
0.811 | 0.061 | 1 | 0.579 |
ULK1 |
0.811 | -0.140 | -3 | 0.792 |
NIM1 |
0.811 | -0.031 | 3 | 0.812 |
PAK1 |
0.811 | 0.013 | -2 | 0.756 |
IRE1 |
0.811 | -0.032 | 1 | 0.771 |
MELK |
0.811 | 0.009 | -3 | 0.776 |
DLK |
0.811 | -0.107 | 1 | 0.776 |
PKACG |
0.810 | 0.006 | -2 | 0.709 |
P38A |
0.810 | 0.091 | 1 | 0.662 |
PRKD3 |
0.809 | 0.010 | -3 | 0.698 |
PAK3 |
0.809 | -0.011 | -2 | 0.760 |
ANKRD3 |
0.809 | -0.123 | 1 | 0.785 |
CAMK2A |
0.809 | 0.013 | 2 | 0.629 |
VRK2 |
0.808 | -0.055 | 1 | 0.825 |
TTBK2 |
0.808 | -0.065 | 2 | 0.643 |
MLK3 |
0.808 | -0.028 | 2 | 0.600 |
IRE2 |
0.808 | -0.024 | 2 | 0.613 |
CHAK1 |
0.808 | 0.001 | 2 | 0.679 |
BCKDK |
0.808 | -0.121 | -1 | 0.732 |
RIPK1 |
0.807 | -0.141 | 1 | 0.752 |
AURC |
0.807 | 0.035 | -2 | 0.617 |
RSK4 |
0.807 | 0.032 | -3 | 0.680 |
MLK4 |
0.807 | -0.020 | 2 | 0.588 |
CDK5 |
0.807 | 0.051 | 1 | 0.635 |
GSK3B |
0.807 | 0.146 | 4 | 0.620 |
LATS1 |
0.807 | -0.002 | -3 | 0.804 |
BMPR1B |
0.806 | 0.045 | 1 | 0.780 |
ALK4 |
0.806 | -0.024 | -2 | 0.760 |
MNK2 |
0.806 | 0.011 | -2 | 0.770 |
TGFBR1 |
0.805 | -0.006 | -2 | 0.734 |
P38B |
0.805 | 0.087 | 1 | 0.599 |
CAMK4 |
0.805 | -0.082 | -3 | 0.802 |
CDK7 |
0.805 | 0.020 | 1 | 0.616 |
JNK2 |
0.805 | 0.044 | 1 | 0.550 |
PKCB |
0.805 | -0.010 | 2 | 0.607 |
MEK1 |
0.804 | -0.122 | 2 | 0.686 |
GSK3A |
0.804 | 0.156 | 4 | 0.626 |
DYRK2 |
0.804 | 0.011 | 1 | 0.661 |
PKCZ |
0.804 | -0.008 | 2 | 0.659 |
SRPK2 |
0.804 | 0.010 | -3 | 0.598 |
PLK1 |
0.804 | -0.085 | -2 | 0.775 |
ERK1 |
0.804 | 0.064 | 1 | 0.576 |
PKCA |
0.804 | -0.023 | 2 | 0.594 |
SMG1 |
0.804 | -0.029 | 1 | 0.715 |
NUAK1 |
0.803 | -0.041 | -3 | 0.763 |
PKCG |
0.803 | -0.028 | 2 | 0.593 |
GRK4 |
0.803 | -0.083 | -2 | 0.742 |
QSK |
0.803 | -0.013 | 4 | 0.724 |
ATM |
0.803 | -0.065 | 1 | 0.695 |
IRAK4 |
0.802 | 0.015 | 1 | 0.773 |
NEK2 |
0.802 | -0.076 | 2 | 0.687 |
PIM2 |
0.802 | 0.021 | -3 | 0.700 |
AURB |
0.802 | 0.002 | -2 | 0.616 |
CLK1 |
0.802 | 0.028 | -3 | 0.709 |
PKCH |
0.802 | -0.038 | 2 | 0.592 |
CDK18 |
0.802 | 0.041 | 1 | 0.548 |
JNK3 |
0.801 | 0.016 | 1 | 0.587 |
MPSK1 |
0.800 | 0.152 | 1 | 0.757 |
PKG2 |
0.800 | 0.023 | -2 | 0.646 |
QIK |
0.800 | -0.088 | -3 | 0.805 |
CDK13 |
0.800 | -0.008 | 1 | 0.584 |
SRPK3 |
0.800 | -0.004 | -3 | 0.644 |
MNK1 |
0.800 | -0.002 | -2 | 0.772 |
SIK |
0.800 | -0.023 | -3 | 0.726 |
CDK1 |
0.800 | 0.021 | 1 | 0.574 |
PKACB |
0.799 | 0.028 | -2 | 0.638 |
PAK2 |
0.799 | -0.054 | -2 | 0.741 |
MSK2 |
0.799 | -0.067 | -3 | 0.668 |
ACVR2B |
0.799 | -0.015 | -2 | 0.735 |
YSK4 |
0.799 | -0.132 | 1 | 0.707 |
BRAF |
0.799 | -0.057 | -4 | 0.762 |
ALK2 |
0.799 | -0.023 | -2 | 0.742 |
CLK4 |
0.798 | -0.006 | -3 | 0.721 |
MYLK4 |
0.798 | -0.046 | -2 | 0.721 |
ERK2 |
0.798 | 0.008 | 1 | 0.615 |
MSK1 |
0.798 | -0.025 | -3 | 0.685 |
PINK1 |
0.798 | -0.064 | 1 | 0.788 |
DCAMKL1 |
0.798 | -0.003 | -3 | 0.757 |
WNK4 |
0.797 | -0.040 | -2 | 0.851 |
CAMK1G |
0.797 | -0.041 | -3 | 0.717 |
PLK3 |
0.797 | -0.083 | 2 | 0.629 |
MAPKAPK5 |
0.797 | -0.076 | -3 | 0.651 |
ACVR2A |
0.797 | -0.035 | -2 | 0.725 |
PAK4 |
0.797 | 0.144 | -2 | 0.635 |
MEKK1 |
0.797 | -0.068 | 1 | 0.756 |
PHKG1 |
0.797 | -0.073 | -3 | 0.789 |
TLK2 |
0.796 | -0.087 | 1 | 0.739 |
SSTK |
0.796 | -0.006 | 4 | 0.715 |
CDK17 |
0.796 | 0.016 | 1 | 0.491 |
SGK3 |
0.796 | -0.004 | -3 | 0.720 |
MARK3 |
0.796 | -0.046 | 4 | 0.692 |
P38G |
0.796 | 0.031 | 1 | 0.489 |
MARK2 |
0.796 | -0.060 | 4 | 0.641 |
NEK5 |
0.796 | -0.047 | 1 | 0.771 |
BRSK1 |
0.795 | -0.068 | -3 | 0.753 |
AKT2 |
0.795 | 0.001 | -3 | 0.637 |
GRK7 |
0.795 | -0.000 | 1 | 0.697 |
PAK5 |
0.795 | 0.106 | -2 | 0.634 |
PRKX |
0.795 | 0.056 | -3 | 0.644 |
DNAPK |
0.795 | -0.037 | 1 | 0.593 |
PERK |
0.795 | -0.100 | -2 | 0.781 |
BRSK2 |
0.794 | -0.079 | -3 | 0.790 |
GAK |
0.794 | 0.053 | 1 | 0.794 |
MEKK2 |
0.794 | -0.065 | 2 | 0.685 |
KIS |
0.794 | -0.037 | 1 | 0.647 |
HRI |
0.794 | -0.122 | -2 | 0.815 |
CDK16 |
0.794 | 0.055 | 1 | 0.509 |
SMMLCK |
0.794 | -0.046 | -3 | 0.773 |
CAMKK1 |
0.793 | -0.031 | -2 | 0.807 |
MEK5 |
0.793 | -0.180 | 2 | 0.685 |
HIPK1 |
0.793 | 0.009 | 1 | 0.678 |
PRP4 |
0.793 | -0.020 | -3 | 0.691 |
SNRK |
0.792 | -0.149 | 2 | 0.569 |
ZAK |
0.792 | -0.105 | 1 | 0.739 |
CLK2 |
0.792 | 0.044 | -3 | 0.698 |
HIPK2 |
0.792 | 0.033 | 1 | 0.572 |
MST3 |
0.792 | -0.021 | 2 | 0.674 |
BMPR1A |
0.791 | 0.017 | 1 | 0.762 |
CDK2 |
0.791 | -0.049 | 1 | 0.643 |
GRK2 |
0.791 | -0.056 | -2 | 0.654 |
DYRK1A |
0.791 | 0.004 | 1 | 0.675 |
CDK12 |
0.791 | -0.016 | 1 | 0.554 |
CAMKK2 |
0.791 | -0.015 | -2 | 0.811 |
PHKG2 |
0.791 | -0.028 | -3 | 0.789 |
DCAMKL2 |
0.791 | -0.045 | -3 | 0.788 |
CAMK1D |
0.791 | -0.009 | -3 | 0.648 |
CDK9 |
0.791 | -0.032 | 1 | 0.590 |
CDK14 |
0.790 | 0.010 | 1 | 0.581 |
MARK1 |
0.790 | -0.082 | 4 | 0.708 |
P70S6K |
0.790 | -0.022 | -3 | 0.656 |
IRAK1 |
0.790 | -0.115 | -1 | 0.695 |
TAO3 |
0.789 | -0.027 | 1 | 0.724 |
PASK |
0.789 | -0.032 | -3 | 0.792 |
EEF2K |
0.789 | 0.022 | 3 | 0.821 |
MEKK3 |
0.788 | -0.175 | 1 | 0.736 |
PLK4 |
0.788 | -0.138 | 2 | 0.522 |
P38D |
0.788 | 0.033 | 1 | 0.512 |
CDK3 |
0.787 | 0.019 | 1 | 0.514 |
CDK10 |
0.787 | 0.027 | 1 | 0.566 |
PKCT |
0.787 | -0.060 | 2 | 0.610 |
TAO2 |
0.787 | -0.043 | 2 | 0.707 |
ERK7 |
0.787 | -0.013 | 2 | 0.419 |
AURA |
0.787 | -0.040 | -2 | 0.574 |
TTBK1 |
0.787 | -0.100 | 2 | 0.558 |
PKACA |
0.786 | 0.011 | -2 | 0.591 |
DRAK1 |
0.786 | -0.137 | 1 | 0.652 |
AKT1 |
0.786 | -0.009 | -3 | 0.662 |
HIPK3 |
0.786 | -0.018 | 1 | 0.656 |
MAK |
0.786 | 0.133 | -2 | 0.836 |
CK1E |
0.785 | -0.030 | -3 | 0.536 |
TLK1 |
0.785 | -0.155 | -2 | 0.760 |
DAPK3 |
0.785 | -0.014 | -3 | 0.757 |
MOK |
0.784 | 0.098 | 1 | 0.722 |
VRK1 |
0.784 | -0.014 | 2 | 0.712 |
PKCI |
0.784 | -0.060 | 2 | 0.602 |
NEK4 |
0.784 | -0.062 | 1 | 0.731 |
CK2A2 |
0.782 | 0.033 | 1 | 0.676 |
DYRK4 |
0.782 | -0.018 | 1 | 0.581 |
DYRK3 |
0.782 | -0.025 | 1 | 0.684 |
LKB1 |
0.782 | -0.069 | -3 | 0.797 |
HGK |
0.781 | -0.035 | 3 | 0.834 |
MEKK6 |
0.781 | -0.050 | 1 | 0.765 |
NEK8 |
0.780 | -0.171 | 2 | 0.676 |
PKCE |
0.780 | -0.030 | 2 | 0.578 |
MAP3K15 |
0.780 | -0.065 | 1 | 0.707 |
NEK11 |
0.780 | -0.184 | 1 | 0.705 |
LRRK2 |
0.780 | -0.095 | 2 | 0.700 |
BUB1 |
0.779 | 0.027 | -5 | 0.792 |
TNIK |
0.779 | -0.007 | 3 | 0.814 |
NEK1 |
0.779 | -0.043 | 1 | 0.748 |
CAMK1A |
0.779 | -0.015 | -3 | 0.605 |
DYRK1B |
0.779 | -0.030 | 1 | 0.596 |
MRCKB |
0.779 | 0.012 | -3 | 0.702 |
CDK4 |
0.779 | 0.013 | 1 | 0.545 |
CDK6 |
0.778 | 0.007 | 1 | 0.559 |
MST2 |
0.778 | -0.119 | 1 | 0.736 |
PLK2 |
0.778 | -0.013 | -3 | 0.793 |
PDK1 |
0.777 | -0.120 | 1 | 0.700 |
MINK |
0.777 | -0.066 | 1 | 0.729 |
JNK1 |
0.777 | -0.011 | 1 | 0.535 |
CK1A2 |
0.777 | -0.030 | -3 | 0.485 |
MRCKA |
0.777 | -0.007 | -3 | 0.719 |
CHK2 |
0.776 | -0.040 | -3 | 0.589 |
GCK |
0.776 | -0.083 | 1 | 0.716 |
ROCK2 |
0.776 | 0.012 | -3 | 0.751 |
DAPK1 |
0.776 | -0.040 | -3 | 0.733 |
LOK |
0.776 | -0.056 | -2 | 0.785 |
TAK1 |
0.775 | -0.129 | 1 | 0.754 |
DMPK1 |
0.775 | 0.041 | -3 | 0.729 |
CK1D |
0.775 | -0.048 | -3 | 0.486 |
GRK3 |
0.774 | -0.054 | -2 | 0.589 |
BIKE |
0.774 | 0.052 | 1 | 0.678 |
PKN1 |
0.774 | -0.070 | -3 | 0.683 |
CK2A1 |
0.774 | 0.032 | 1 | 0.650 |
PBK |
0.773 | 0.008 | 1 | 0.726 |
YSK1 |
0.773 | -0.057 | 2 | 0.680 |
SBK |
0.773 | -0.025 | -3 | 0.515 |
CK1G1 |
0.772 | -0.060 | -3 | 0.518 |
PDHK3_TYR |
0.772 | 0.103 | 4 | 0.856 |
KHS1 |
0.771 | -0.017 | 1 | 0.705 |
MST1 |
0.771 | -0.122 | 1 | 0.722 |
STK33 |
0.771 | -0.128 | 2 | 0.510 |
HASPIN |
0.770 | 0.051 | -1 | 0.665 |
AKT3 |
0.770 | -0.020 | -3 | 0.559 |
TTK |
0.769 | -0.015 | -2 | 0.764 |
MEK2 |
0.769 | -0.180 | 2 | 0.692 |
HPK1 |
0.769 | -0.096 | 1 | 0.697 |
SGK1 |
0.768 | -0.028 | -3 | 0.546 |
RIPK2 |
0.767 | -0.200 | 1 | 0.669 |
KHS2 |
0.766 | -0.032 | 1 | 0.710 |
CRIK |
0.765 | 0.012 | -3 | 0.649 |
NEK3 |
0.765 | -0.122 | 1 | 0.709 |
SLK |
0.764 | -0.108 | -2 | 0.723 |
PKG1 |
0.764 | -0.015 | -2 | 0.562 |
ROCK1 |
0.763 | -0.011 | -3 | 0.718 |
PKMYT1_TYR |
0.761 | -0.045 | 3 | 0.866 |
AAK1 |
0.761 | 0.078 | 1 | 0.585 |
TESK1_TYR |
0.761 | -0.090 | 3 | 0.871 |
OSR1 |
0.761 | -0.089 | 2 | 0.659 |
MYO3B |
0.761 | -0.043 | 2 | 0.679 |
PDHK4_TYR |
0.760 | -0.061 | 2 | 0.704 |
LIMK2_TYR |
0.759 | 0.014 | -3 | 0.861 |
EPHA6 |
0.759 | 0.052 | -1 | 0.822 |
BMPR2_TYR |
0.759 | -0.024 | -1 | 0.818 |
MAP2K4_TYR |
0.758 | -0.120 | -1 | 0.809 |
MAP2K6_TYR |
0.758 | -0.090 | -1 | 0.813 |
EPHB4 |
0.758 | 0.052 | -1 | 0.802 |
MAP2K7_TYR |
0.757 | -0.206 | 2 | 0.708 |
MYO3A |
0.757 | -0.072 | 1 | 0.729 |
ASK1 |
0.757 | -0.132 | 1 | 0.696 |
TXK |
0.756 | 0.112 | 1 | 0.798 |
PINK1_TYR |
0.755 | -0.160 | 1 | 0.779 |
ALPHAK3 |
0.754 | -0.094 | -1 | 0.712 |
PDHK1_TYR |
0.754 | -0.122 | -1 | 0.825 |
YANK3 |
0.753 | -0.077 | 2 | 0.330 |
TAO1 |
0.753 | -0.093 | 1 | 0.656 |
DDR1 |
0.753 | -0.043 | 4 | 0.770 |
RET |
0.752 | -0.079 | 1 | 0.747 |
YES1 |
0.752 | 0.042 | -1 | 0.797 |
TYRO3 |
0.752 | -0.050 | 3 | 0.817 |
TYK2 |
0.752 | -0.084 | 1 | 0.749 |
ROS1 |
0.751 | -0.041 | 3 | 0.800 |
LIMK1_TYR |
0.750 | -0.146 | 2 | 0.717 |
TNK2 |
0.750 | 0.046 | 3 | 0.777 |
ABL2 |
0.750 | 0.043 | -1 | 0.754 |
EPHB1 |
0.750 | 0.025 | 1 | 0.810 |
JAK2 |
0.749 | -0.073 | 1 | 0.749 |
EPHB3 |
0.749 | 0.020 | -1 | 0.791 |
EPHA4 |
0.749 | -0.019 | 2 | 0.609 |
ITK |
0.748 | 0.034 | -1 | 0.754 |
MST1R |
0.747 | -0.117 | 3 | 0.828 |
ABL1 |
0.747 | 0.031 | -1 | 0.745 |
CSF1R |
0.747 | -0.054 | 3 | 0.816 |
HCK |
0.747 | 0.014 | -1 | 0.788 |
EPHB2 |
0.747 | 0.021 | -1 | 0.784 |
BLK |
0.747 | 0.091 | -1 | 0.802 |
TNNI3K_TYR |
0.746 | 0.025 | 1 | 0.817 |
FGR |
0.746 | -0.035 | 1 | 0.808 |
STLK3 |
0.746 | -0.155 | 1 | 0.693 |
LCK |
0.746 | 0.070 | -1 | 0.792 |
FER |
0.746 | -0.069 | 1 | 0.827 |
INSRR |
0.745 | -0.060 | 3 | 0.793 |
SRMS |
0.745 | -0.031 | 1 | 0.811 |
TNK1 |
0.744 | -0.023 | 3 | 0.806 |
PDGFRB |
0.744 | -0.080 | 3 | 0.836 |
JAK3 |
0.743 | -0.098 | 1 | 0.724 |
BMX |
0.743 | 0.007 | -1 | 0.702 |
EPHA7 |
0.742 | 0.000 | 2 | 0.624 |
MERTK |
0.742 | -0.017 | 3 | 0.803 |
TEC |
0.741 | 0.013 | -1 | 0.712 |
AXL |
0.741 | -0.050 | 3 | 0.805 |
DDR2 |
0.741 | 0.052 | 3 | 0.787 |
LTK |
0.740 | -0.028 | 3 | 0.800 |
FYN |
0.740 | 0.051 | -1 | 0.780 |
CK1A |
0.739 | -0.060 | -3 | 0.397 |
TEK |
0.739 | -0.105 | 3 | 0.778 |
KDR |
0.738 | -0.088 | 3 | 0.803 |
FGFR2 |
0.738 | -0.148 | 3 | 0.836 |
FLT3 |
0.738 | -0.110 | 3 | 0.821 |
JAK1 |
0.737 | -0.055 | 1 | 0.675 |
ALK |
0.737 | -0.065 | 3 | 0.777 |
FGFR1 |
0.737 | -0.129 | 3 | 0.809 |
BTK |
0.737 | -0.076 | -1 | 0.718 |
EPHA3 |
0.736 | -0.083 | 2 | 0.601 |
KIT |
0.736 | -0.119 | 3 | 0.828 |
EPHA1 |
0.736 | -0.029 | 3 | 0.791 |
PDGFRA |
0.736 | -0.145 | 3 | 0.830 |
NEK10_TYR |
0.736 | -0.126 | 1 | 0.606 |
LYN |
0.735 | 0.003 | 3 | 0.784 |
FRK |
0.734 | -0.034 | -1 | 0.803 |
PTK6 |
0.734 | -0.124 | -1 | 0.669 |
MET |
0.733 | -0.080 | 3 | 0.803 |
EPHA5 |
0.732 | -0.037 | 2 | 0.602 |
NTRK1 |
0.732 | -0.147 | -1 | 0.751 |
WEE1_TYR |
0.732 | -0.104 | -1 | 0.692 |
PTK2B |
0.731 | -0.035 | -1 | 0.744 |
NTRK2 |
0.730 | -0.130 | 3 | 0.800 |
INSR |
0.729 | -0.114 | 3 | 0.763 |
EPHA8 |
0.729 | -0.038 | -1 | 0.776 |
FLT4 |
0.728 | -0.147 | 3 | 0.810 |
SRC |
0.728 | -0.019 | -1 | 0.768 |
ERBB2 |
0.728 | -0.151 | 1 | 0.696 |
FLT1 |
0.726 | -0.135 | -1 | 0.760 |
NTRK3 |
0.726 | -0.103 | -1 | 0.711 |
YANK2 |
0.724 | -0.091 | 2 | 0.341 |
FGFR3 |
0.724 | -0.180 | 3 | 0.813 |
CSK |
0.724 | -0.092 | 2 | 0.632 |
PTK2 |
0.723 | -0.019 | -1 | 0.754 |
MATK |
0.722 | -0.118 | -1 | 0.677 |
EGFR |
0.718 | -0.114 | 1 | 0.614 |
EPHA2 |
0.718 | -0.071 | -1 | 0.733 |
CK1G3 |
0.718 | -0.084 | -3 | 0.347 |
IGF1R |
0.713 | -0.127 | 3 | 0.725 |
SYK |
0.713 | -0.060 | -1 | 0.732 |
MUSK |
0.712 | -0.133 | 1 | 0.595 |
FGFR4 |
0.712 | -0.141 | -1 | 0.705 |
ERBB4 |
0.710 | -0.083 | 1 | 0.640 |
FES |
0.704 | -0.112 | -1 | 0.668 |
CK1G2 |
0.698 | -0.086 | -3 | 0.440 |
ZAP70 |
0.683 | -0.121 | -1 | 0.663 |