Motif 830 (n=123)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0G2JPF8 | HNRNPCL4 | S31 | ochoa | Heterogeneous nuclear ribonucleoprotein C like 4 | None |
| A0AV02 | SLC12A8 | S665 | ochoa | Solute carrier family 12 member 8 (Cation-chloride cotransporter 9) | Cation/chloride cotransporter that may play a role in the control of keratinocyte proliferation. {ECO:0000269|PubMed:11863360}. |
| A2A3K4 | PTPDC1 | S472 | ochoa | Protein tyrosine phosphatase domain-containing protein 1 (EC 3.1.3.-) | May play roles in cilia formation and/or maintenance. {ECO:0000250}. |
| A6NEL2 | SOWAHB | S742 | ochoa | Ankyrin repeat domain-containing protein SOWAHB (Ankyrin repeat domain-containing protein 56) (Protein sosondowah homolog B) | None |
| B2RXH8 | HNRNPCL2 | S31 | ochoa | Heterogeneous nuclear ribonucleoprotein C-like 2 (hnRNP C-like-2) | May play a role in nucleosome assembly by neutralizing basic proteins such as A and B core hnRNPs. {ECO:0000250}. |
| B7ZW38 | HNRNPCL3 | S31 | ochoa | Heterogeneous nuclear ribonucleoprotein C-like 3 | None |
| B8ZZF3 | None | S196 | ochoa | Mediator of RNA polymerase II transcription subunit 26 (Cofactor required for Sp1 transcriptional activation subunit 7) (Mediator complex subunit 26) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. {ECO:0000256|ARBA:ARBA00057523}. |
| H3BQZ7 | HNRNPUL2-BSCL2 | S543 | ochoa | Heterogeneous nuclear ribonucleoprotein U-like protein 2 | None |
| O14686 | KMT2D | S3986 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O14978 | ZNF263 | S166 | ochoa | Zinc finger protein 263 (Zinc finger protein FPM315) (Zinc finger protein with KRAB and SCAN domains 12) | Transcription factor that binds to the consensus sequence 5'-TCCTCCC-3' and acts as a transcriptional repressor (PubMed:32051553). Binds to the promoter region of SIX3 and recruits other proteins involved in chromatin modification and transcriptional corepression, resulting in methylation of the promoter and transcriptional repression (PubMed:32051553). Acts as a transcriptional repressor of HS3ST1 and HS3ST3A1 via binding to gene promoter regions (PubMed:32277030). {ECO:0000269|PubMed:32051553, ECO:0000269|PubMed:32277030}. |
| O15042 | U2SURP | S485 | ochoa | U2 snRNP-associated SURP motif-containing protein (140 kDa Ser/Arg-rich domain protein) (U2-associated protein SR140) | None |
| O15085 | ARHGEF11 | S1458 | ochoa | Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth. {ECO:0000269|PubMed:21670212}. |
| O43299 | AP5Z1 | S776 | ochoa | AP-5 complex subunit zeta-1 (Adaptor-related protein complex 5 zeta subunit) (Zeta5) | As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed:20613862 it is a putative helicase required for efficient homologous recombination DNA double-strand break repair. {ECO:0000269|PubMed:20613862, ECO:0000269|PubMed:22022230}. |
| O43464 | HTRA2 | S400 | psp | Serine protease HTRA2, mitochondrial (EC 3.4.21.108) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine protease 25) (Serine proteinase OMI) | [Isoform 1]: Serine protease that shows proteolytic activity against a non-specific substrate beta-casein (PubMed:10873535). Promotes apoptosis by either relieving the inhibition of BIRC proteins on caspases, leading to an increase in caspase activity; or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism (PubMed:15200957). Cleaves BIRC6 and relieves its inhibition on CASP3, CASP7 and CASP9, but it is also prone to inhibition by BIRC6 (PubMed:36758104, PubMed:36758105). Cleaves THAP5 and promotes its degradation during apoptosis (PubMed:19502560). {ECO:0000269|PubMed:10873535, ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:19502560, ECO:0000269|PubMed:36758104, ECO:0000269|PubMed:36758105}.; FUNCTION: [Isoform 2]: Seems to be proteolytically inactive. {ECO:0000269|PubMed:10995577}. |
| O60812 | HNRNPCL1 | S31 | ochoa | Heterogeneous nuclear ribonucleoprotein C-like 1 (hnRNP C-like-1) (hnRNP core protein C-like 1) | May play a role in nucleosome assembly by neutralizing basic proteins such as A and B core hnRNPs. {ECO:0000250}. |
| O94886 | TMEM63A | S768 | ochoa | Mechanosensitive cation channel TMEM63A (Transmembrane protein 63A) (hTMEM63A) | Mechanosensitive cation channel with low conductance and high activation threshold (PubMed:30382938, PubMed:31587869, PubMed:37543036). In contrast to TMEM63B, does not show phospholipid scramblase activity (PubMed:39716028). Acts as a regulator of lysosomal morphology by mediating lysosomal mechanosensitivity (By similarity). Important for the baby's first breath and respiration throughout life (PubMed:38127458). Upon lung inflation conducts cation currents in alveolar type 1 and 2 cells triggering lamellar body exocytosis and surfactant secretion into airspace (PubMed:38127458). Also acts as an osmosensitive cation channel preferentially activated by hypotonic stress (By similarity). {ECO:0000250|UniProtKB:Q91YT8, ECO:0000269|PubMed:30382938, ECO:0000269|PubMed:31587869, ECO:0000269|PubMed:37543036, ECO:0000269|PubMed:38127458, ECO:0000269|PubMed:39716028}. |
| O95402 | MED26 | S188 | ochoa | Mediator of RNA polymerase II transcription subunit 26 (Activator-recruited cofactor 70 kDa component) (ARC70) (Cofactor required for Sp1 transcriptional activation subunit 7) (CRSP complex subunit 7) (Mediator complex subunit 26) (Transcriptional coactivator CRSP70) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. |
| O95466 | FMNL1 | S950 | ochoa | Formin-like protein 1 (CLL-associated antigen KW-13) (Leukocyte formin) | May play a role in the control of cell motility and survival of macrophages (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. {ECO:0000250, ECO:0000269|PubMed:21834987}. |
| O95782 | AP2A1 | S518 | ochoa | AP-2 complex subunit alpha-1 (100 kDa coated vesicle protein A) (Adaptor protein complex AP-2 subunit alpha-1) (Adaptor-related protein complex 2 subunit alpha-1) (Alpha-adaptin A) (Alpha1-adaptin) (Clathrin assembly protein complex 2 alpha-A large chain) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit) | Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (PubMed:23676497). The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity). {ECO:0000250, ECO:0000269|PubMed:14745134, ECO:0000269|PubMed:15473838, ECO:0000269|PubMed:19033387, ECO:0000269|PubMed:23676497}. |
| P07910 | HNRNPC | S31 | ochoa | Heterogeneous nuclear ribonucleoproteins C1/C2 (hnRNP C1/C2) | Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621). May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671). {ECO:0000269|PubMed:12509468, ECO:0000269|PubMed:16010978, ECO:0000269|PubMed:25719671, ECO:0000269|PubMed:7567451, ECO:0000269|PubMed:8264621}. |
| P08237 | PFKM | S667 | ochoa | ATP-dependent 6-phosphofructokinase, muscle type (ATP-PFK) (PFK-M) (EC 2.7.1.11) (6-phosphofructokinase type A) (Phosphofructo-1-kinase isozyme A) (PFK-A) (Phosphohexokinase) | Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. |
| P0DMB2 | C8orf88 | S70 | ochoa | Uncharacterized protein C8orf88 | None |
| P0DMR1 | HNRNPCL4 | S31 | ochoa | Heterogeneous nuclear ribonucleoprotein C-like 4 | None |
| P10721 | KIT | S931 | ochoa | Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117) | Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1. {ECO:0000269|PubMed:10397721, ECO:0000269|PubMed:12444928, ECO:0000269|PubMed:12511554, ECO:0000269|PubMed:12878163, ECO:0000269|PubMed:17904548, ECO:0000269|PubMed:19265199, ECO:0000269|PubMed:21135090, ECO:0000269|PubMed:21640708, ECO:0000269|PubMed:7520444, ECO:0000269|PubMed:9528781}. |
| P12109 | COL6A1 | S746 | ochoa | Collagen alpha-1(VI) chain | Collagen VI acts as a cell-binding protein. |
| P13196 | ALAS1 | S85 | ochoa | 5-aminolevulinate synthase, non-specific, mitochondrial (ALAS-H) (EC 2.3.1.37) (5-aminolevulinic acid synthase 1) (Delta-ALA synthase 1) (Delta-aminolevulinate synthase 1) | Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products. {ECO:0000269|PubMed:16234850, ECO:0000269|PubMed:17975826}. |
| P14316 | IRF2 | S155 | ochoa | Interferon regulatory factor 2 (IRF-2) | Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation. {ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:15226432, ECO:0000269|PubMed:18514056, ECO:0000269|PubMed:9540062}. |
| P25098 | GRK2 | S389 | ochoa | Beta-adrenergic receptor kinase 1 (Beta-ARK-1) (EC 2.7.11.15) (G-protein coupled receptor kinase 2) | Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them (PubMed:19715378). Key regulator of LPAR1 signaling (PubMed:19306925). Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor (PubMed:19306925). Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (PubMed:19306925). Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity (By similarity). Inhibits relaxation of airway smooth muscle in response to blue light (PubMed:30284927). {ECO:0000250|UniProtKB:P21146, ECO:0000269|PubMed:19306925, ECO:0000269|PubMed:19715378, ECO:0000269|PubMed:30284927}. |
| P25391 | LAMA1 | S3048 | ochoa | Laminin subunit alpha-1 (Laminin A chain) (Laminin-1 subunit alpha) (Laminin-3 subunit alpha) (S-laminin subunit alpha) (S-LAM alpha) | Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. |
| P29323 | EPHB2 | S776 | ochoa | Ephrin type-B receptor 2 (EC 2.7.10.1) (Developmentally-regulated Eph-related tyrosine kinase) (ELK-related tyrosine kinase) (EPH tyrosine kinase 3) (EPH-like kinase 5) (EK5) (hEK5) (Renal carcinoma antigen NY-REN-47) (Tyrosine-protein kinase TYRO5) (Tyrosine-protein kinase receptor EPH-3) [Cleaved into: EphB2/CTF1; EphB2/CTF2] | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor. May be involved in the regulation of platelet activation and blood coagulation (PubMed:30213874). {ECO:0000269|PubMed:15300251, ECO:0000269|PubMed:30213874}. |
| P30876 | POLR2B | S487 | ochoa | DNA-directed RNA polymerase II subunit RPB2 (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II 140 kDa polypeptide) (DNA-directed RNA polymerase II subunit B) (RNA polymerase II subunit 2) (RNA polymerase II subunit B2) (RNA-directed RNA polymerase II subunit RPB2) (EC 2.7.7.48) | Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (PubMed:27193682, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the largest subunit POLR2A/RPB1. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). {ECO:0000250|UniProtKB:A5PJW8, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:8381534, ECO:0000269|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269|PubMed:23395899}. |
| P33981 | TTK | S821 | ochoa|psp | Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT) | Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (PubMed:18243099, PubMed:28441529, PubMed:29162720). Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint (PubMed:18243099, PubMed:29162720). Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore (PubMed:18243099). Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments (PubMed:28441529). Phosphorylates KNL1, KNTC1 and autophosphorylates (PubMed:28441529). Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment (PubMed:30785839). {ECO:0000269|PubMed:18243099, ECO:0000269|PubMed:28441529, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:30785839}. |
| P35573 | AGL | S871 | ochoa | Glycogen debranching enzyme (Glycogen debrancher) [Includes: 4-alpha-glucanotransferase (EC 2.4.1.25) (Oligo-1,4-1,4-glucantransferase); Amylo-alpha-1,6-glucosidase (Amylo-1,6-glucosidase) (EC 3.2.1.33) (Dextrin 6-alpha-D-glucosidase)] | Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. |
| P35626 | GRK3 | S389 | ochoa | G protein-coupled receptor kinase 3 (EC 2.7.11.15) (Beta-adrenergic receptor kinase 2) (Beta-ARK-2) | Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors. {ECO:0000250|UniProtKB:P26819}. |
| P35680 | HNF1B | S334 | ochoa | Hepatocyte nuclear factor 1-beta (HNF-1-beta) (HNF-1B) (Homeoprotein LFB3) (Transcription factor 2) (TCF-2) (Variant hepatic nuclear factor 1) (vHNF1) | Transcription factor that binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (PubMed:17924661, PubMed:7900999). Binds to the FPC element in the cAMP regulatory unit of the PLAU gene (By similarity). Transcriptional activity is increased by coactivator PCBD1 (PubMed:24204001). {ECO:0000250|UniProtKB:Q03365, ECO:0000269|PubMed:17924661, ECO:0000269|PubMed:24204001, ECO:0000269|PubMed:7900999}. |
| P39880 | CUX1 | S749 | ochoa | Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (CDP/Cux p200) (Homeobox protein cux-1) [Cleaved into: CDP/Cux p110] | Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator. {ECO:0000250|UniProtKB:P53564}.; FUNCTION: [CDP/Cux p110]: Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1. {ECO:0000269|PubMed:15099520}. |
| P41970 | ELK3 | S115 | ochoa | ETS domain-containing protein Elk-3 (ETS-related protein ERP) (ETS-related protein NET) (Serum response factor accessory protein 2) (SAP-2) (SRF accessory protein 2) | May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element. |
| P43243 | MATR3 | S511 | ochoa | Matrin-3 | May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32245947}. |
| P49756 | RBM25 | S677 | ochoa | RNA-binding protein 25 (Arg/Glu/Asp-rich protein of 120 kDa) (RED120) (Protein S164) (RNA-binding motif protein 25) (RNA-binding region-containing protein 7) | RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA. Also involved in the generation of an abnormal and truncated splice form of SCN5A in heart failure. {ECO:0000269|PubMed:18663000, ECO:0000269|PubMed:21859973}. |
| P51610 | HCFC1 | S1222 | ochoa | Host cell factor 1 (HCF) (HCF-1) (C1 factor) (CFF) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6] | Transcriptional coregulator (By similarity). Serves as a scaffold protein, bridging interactions between transcription factors, including THAP11 and ZNF143, and transcriptional coregulators (PubMed:26416877). Involved in control of the cell cycle (PubMed:10629049, PubMed:10779346, PubMed:15190068, PubMed:16624878, PubMed:23629655). Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300 (PubMed:10675337, PubMed:12244100). Coactivator for EGR2 and GABP2 (PubMed:12244100, PubMed:14532282). Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together (PubMed:12670868). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (PubMed:20200153). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Recruits KMT2E/MLL5 to E2F1 responsive promoters promoting transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). Modulates expression of homeobox protein PDX1, perhaps acting in concert with transcription factor E2F1, thereby regulating pancreatic beta-cell growth and glucose-stimulated insulin secretion (By similarity). May negatively modulate transcriptional activity of FOXO3 (By similarity). {ECO:0000250|UniProtKB:D3ZN95, ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:10675337, ECO:0000269|PubMed:10779346, ECO:0000269|PubMed:12244100, ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:14532282, ECO:0000269|PubMed:15190068, ECO:0000269|PubMed:16624878, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:20200153, ECO:0000269|PubMed:23629655, ECO:0000269|PubMed:26416877}.; FUNCTION: (Microbial infection) In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:17578910}. |
| P52294 | KPNA1 | S244 | ochoa | Importin subunit alpha-5 (Karyopherin subunit alpha-1) (Nucleoprotein interactor 1) (NPI-1) (RAG cohort protein 2) (SRP1-beta) [Cleaved into: Importin subunit alpha-5, N-terminally processed] | Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1 (PubMed:27713473, PubMed:7892216, PubMed:8692858). Binds specifically and directly to substrates containing either a simple or bipartite NLS motif (PubMed:27713473, PubMed:7892216, PubMed:8692858). Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:27713473, PubMed:7892216). At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin (PubMed:7892216). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:7892216). Mediator of PR-DUB complex component BAP1 nuclear import; acts redundantly with KPNA2 and Transportin-1/TNPO1 (PubMed:35446349). {ECO:0000269|PubMed:27713473, ECO:0000269|PubMed:35446349, ECO:0000269|PubMed:7892216, ECO:0000269|PubMed:8692858}.; FUNCTION: (Microbial infection) In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. {ECO:0000269|PubMed:12610148}. |
| P52333 | JAK3 | S493 | ochoa | Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK) | Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A and STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion. {ECO:0000269|PubMed:11909529, ECO:0000269|PubMed:20440074, ECO:0000269|PubMed:7662955, ECO:0000269|PubMed:8022485}. |
| P54578 | USP14 | S302 | ochoa | Ubiquitin carboxyl-terminal hydrolase 14 (EC 3.4.19.12) (Deubiquitinating enzyme 14) (Ubiquitin thioesterase 14) (Ubiquitin-specific-processing protease 14) | Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins (PubMed:35145029). Ensures the regeneration of ubiquitin at the proteasome (PubMed:18162577, PubMed:28396413). Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell (PubMed:18162577). Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (PubMed:19106094). Also serves as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1 (PubMed:19135427). Indispensable for synaptic development and function at neuromuscular junctions (NMJs) (By similarity). Plays a role in the innate immune defense against viruses by stabilizing the viral DNA sensor CGAS and thus inhibiting its autophagic degradation (PubMed:27666593). Inhibits OPTN-mediated selective autophagic degradation of KDM4D and thereby negatively regulates H3K9me2 and H3K9me3 (PubMed:35145029). {ECO:0000250|UniProtKB:Q9JMA1, ECO:0000269|PubMed:18162577, ECO:0000269|PubMed:19106094, ECO:0000269|PubMed:19135427, ECO:0000269|PubMed:27666593, ECO:0000269|PubMed:28396413, ECO:0000269|PubMed:35145029}. |
| P54760 | EPHB4 | S770 | ochoa | Ephrin type-B receptor 4 (EC 2.7.10.1) (Hepatoma transmembrane kinase) (Tyrosine-protein kinase TYRO11) | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. {ECO:0000269|PubMed:12734395, ECO:0000269|PubMed:16424904, ECO:0000269|PubMed:27400125, ECO:0000269|PubMed:30578106}. |
| P54762 | EPHB1 | S774 | ochoa | Ephrin type-B receptor 1 (EC 2.7.10.1) (ELK) (EPH tyrosine kinase 2) (EPH-like kinase 6) (EK6) (hEK6) (Neuronally-expressed EPH-related tyrosine kinase) (NET) (Tyrosine-protein kinase receptor EPH-2) | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance also plays an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively. Involved in the maintenance of the pool of satellite cells (muscle stem cells) by promoting their self-renewal and reducing their activation and differentiation (By similarity). {ECO:0000250|UniProtKB:Q8CBF3, ECO:0000269|PubMed:12223469, ECO:0000269|PubMed:12925710, ECO:0000269|PubMed:18034775, ECO:0000269|PubMed:9430661, ECO:0000269|PubMed:9499402}. |
| P55196 | AFDN | S1107 | ochoa | Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor) | Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). {ECO:0000250|UniProtKB:O35889, ECO:0000250|UniProtKB:Q9QZQ1, ECO:0000269|PubMed:11024295, ECO:0000269|PubMed:30463011}. |
| P55197 | MLLT10 | S536 | ochoa | Protein AF-10 (ALL1-fused gene from chromosome 10 protein) | Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (PubMed:26439302). {ECO:0000269|PubMed:17868029, ECO:0000269|PubMed:26439302}. |
| P60983 | GMFB | S53 | psp | Glia maturation factor beta (GMF-beta) | This protein causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells. |
| P78527 | PRKDC | S2547 | ochoa | DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) | Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250|UniProtKB:P97313, ECO:0000269|PubMed:10026262, ECO:0000269|PubMed:10467406, ECO:0000269|PubMed:11889123, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12509254, ECO:0000269|PubMed:12649176, ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:14612514, ECO:0000269|PubMed:14627815, ECO:0000269|PubMed:14704337, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:15262962, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:1597196, ECO:0000269|PubMed:16046194, ECO:0000269|PubMed:16397295, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:2247066, ECO:0000269|PubMed:2507541, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30247612, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33854234, ECO:0000269|PubMed:34352203, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:8407951, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9362500, ECO:0000269|PubMed:9363941, ECO:0000269|PubMed:9679063}. |
| Q05D32 | CTDSPL2 | S134 | ochoa|psp | CTD small phosphatase-like protein 2 (CTDSP-like 2) (EC 3.1.3.-) | Probable phosphatase. {ECO:0000250}. |
| Q12778 | FOXO1 | S470 | ochoa | Forkhead box protein O1 (Forkhead box protein O1A) (Forkhead in rhabdomyosarcoma) | Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress (PubMed:10358076, PubMed:12228231, PubMed:15220471, PubMed:15890677, PubMed:18356527, PubMed:19221179, PubMed:20543840, PubMed:21245099). Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3' (PubMed:10358076). Activity suppressed by insulin (PubMed:10358076). Main regulator of redox balance and osteoblast numbers and controls bone mass (By similarity). Orchestrates the endocrine function of the skeleton in regulating glucose metabolism (By similarity). Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity (By similarity). Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP (By similarity). Acts as an inhibitor of glucose sensing in pancreatic beta cells by acting as a transcription repressor and suppressing expression of PDX1 (By similarity). In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC1 and PCK1 (By similarity). Also promotes gluconeogenesis by directly promoting expression of PPARGC1A and G6PC1 (PubMed:17024043). Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and STK4/MST1 (PubMed:18356527, PubMed:19221179). Promotes neural cell death (PubMed:18356527). Mediates insulin action on adipose tissue (By similarity). Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake (By similarity). Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells (By similarity). Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner (PubMed:20543840). Mediates the function of MLIP in cardiomyocytes hypertrophy and cardiac remodeling (By similarity). Positive regulator of apoptosis in cardiac smooth muscle cells as a result of its transcriptional activation of pro-apoptotic genes (PubMed:19483080). Regulates endothelial cell (EC) viability and apoptosis in a PPIA/CYPA-dependent manner via transcription of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (PubMed:31063815). {ECO:0000250|UniProtKB:A4L7N3, ECO:0000250|UniProtKB:G3V7R4, ECO:0000250|UniProtKB:Q9R1E0, ECO:0000269|PubMed:10358076, ECO:0000269|PubMed:12228231, ECO:0000269|PubMed:15220471, ECO:0000269|PubMed:15890677, ECO:0000269|PubMed:17024043, ECO:0000269|PubMed:18356527, ECO:0000269|PubMed:19221179, ECO:0000269|PubMed:19483080, ECO:0000269|PubMed:20543840, ECO:0000269|PubMed:21245099, ECO:0000269|PubMed:31063815}. |
| Q12802 | AKAP13 | S1559 | ochoa | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q12802 | AKAP13 | S1683 | ochoa | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q12882 | DPYD | S905 | ochoa | Dihydropyrimidine dehydrogenase [NADP(+)] (DHPDHase) (DPD) (EC 1.3.1.2) (Dihydrothymine dehydrogenase) (Dihydrouracil dehydrogenase) | Involved in pyrimidine base degradation (PubMed:1512248). Catalyzes the reduction of uracil and thymine (PubMed:1512248). Also involved the degradation of the chemotherapeutic drug 5-fluorouracil (PubMed:1512248). {ECO:0000269|PubMed:1512248}. |
| Q13309 | SKP2 | S64 | ochoa|psp | S-phase kinase-associated protein 2 (Cyclin-A/CDK2-associated protein p45) (F-box protein Skp2) (F-box/LRR-repeat protein 1) (p45skp2) | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription (PubMed:9736735, PubMed:11931757, PubMed:12435635, PubMed:12769844, PubMed:12840033, PubMed:15342634, PubMed:15668399, PubMed:15949444, PubMed:16103164, PubMed:16262255, PubMed:16581786, PubMed:16951159, PubMed:17908926, PubMed:17962192, PubMed:22464731, PubMed:22770219, PubMed:32267835). Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition (By similarity). Degradation of CDKN1B/p27kip also requires CKS1 (By similarity). Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, NBN, FOXO1, UBP43, YTHDF2, and probably MYC, TOB1 and TAL1 (PubMed:11931757, PubMed:12435635, PubMed:12769844, PubMed:12840033, PubMed:15342634, PubMed:15668399, PubMed:15949444, PubMed:16103164, PubMed:16581786, PubMed:16951159, PubMed:17908926, PubMed:17962192, PubMed:22464731, PubMed:32267835). Degradation of TAL1 also requires STUB1 (PubMed:17962192). Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2 (PubMed:9736735, PubMed:16262255). Promotes ubiquitination and destruction of CDH1 in a CK1-dependent manner, thereby regulating cell migration (PubMed:22770219). Following phosphorylation in response to DNA damage, mediates 'Lys-63'-linked ubiquitination of NBN, promoting ATM recruitment to DNA damage sites and DNA repair via homologous recombination (PubMed:22464731). {ECO:0000250|UniProtKB:Q9Z0Z3, ECO:0000269|PubMed:11931757, ECO:0000269|PubMed:12435635, ECO:0000269|PubMed:12769844, ECO:0000269|PubMed:12840033, ECO:0000269|PubMed:15342634, ECO:0000269|PubMed:15668399, ECO:0000269|PubMed:15949444, ECO:0000269|PubMed:16103164, ECO:0000269|PubMed:16262255, ECO:0000269|PubMed:16581786, ECO:0000269|PubMed:16951159, ECO:0000269|PubMed:17908926, ECO:0000269|PubMed:17962192, ECO:0000269|PubMed:22464731, ECO:0000269|PubMed:22770219, ECO:0000269|PubMed:32267835, ECO:0000269|PubMed:9736735}.; FUNCTION: Through the ubiquitin-mediated proteasomal degradation of hepatitis C virus non-structural protein 5A, has an antiviral activity towards that virus. {ECO:0000269|PubMed:27194766}. |
| Q13796 | SHROOM2 | S1524 | ochoa | Protein Shroom2 (Apical-like protein) (Protein APXL) | May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). {ECO:0000250}. |
| Q13823 | GNL2 | S68 | ochoa | Nucleolar GTP-binding protein 2 (Autoantigen NGP-1) | GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (PubMed:32669547). May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels (PubMed:26203195). {ECO:0000269|PubMed:26203195, ECO:0000269|PubMed:32669547}. |
| Q14517 | FAT1 | S150 | ochoa | Protocadherin Fat 1 (Cadherin family member 7) (Cadherin-related tumor suppressor homolog) (Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form] | [Protocadherin Fat 1]: Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact. {ECO:0000250}. |
| Q14517 | FAT1 | Y4494 | ochoa | Protocadherin Fat 1 (Cadherin family member 7) (Cadherin-related tumor suppressor homolog) (Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form] | [Protocadherin Fat 1]: Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact. {ECO:0000250}. |
| Q15013 | MAD2L1BP | S102 | ochoa|psp | MAD2L1-binding protein (Caught by MAD2 protein) (p31(comet)) | May function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex. {ECO:0000269|PubMed:18022368}. |
| Q16658 | FSCN1 | S127 | ochoa | Fascin (55 kDa actin-bundling protein) (Singed-like protein) (p55) | Actin-binding protein that contains 2 major actin binding sites (PubMed:21685497, PubMed:23184945). Organizes filamentous actin into parallel bundles (PubMed:20393565, PubMed:21685497, PubMed:23184945). Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers (PubMed:22155786). Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration (PubMed:20393565, PubMed:21685497, PubMed:23184945). Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF (PubMed:22155786). {ECO:0000269|PubMed:20137952, ECO:0000269|PubMed:20393565, ECO:0000269|PubMed:21685497, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:23184945, ECO:0000269|PubMed:9362073, ECO:0000269|PubMed:9571235}. |
| Q1KMD3 | HNRNPUL2 | S543 | ochoa | Heterogeneous nuclear ribonucleoprotein U-like protein 2 (Scaffold-attachment factor A2) (SAF-A2) | None |
| Q2M1K9 | ZNF423 | S1054 | ochoa | Zinc finger protein 423 (Olf1/EBF-associated zinc finger protein) (hOAZ) (Smad- and Olf-interacting zinc finger protein) | Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation; this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons. Controls proliferation and differentiation of neural precursors in cerebellar vermis formation. {ECO:0000269|PubMed:10660046}. |
| Q3T8J9 | GON4L | S1009 | ochoa | GON-4-like protein (GON-4 homolog) | Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A and HDAC1. Required for B cell lymphopoiesis. {ECO:0000250|UniProtKB:Q9DB00}. |
| Q4V9L6 | TMEM119 | S185 | ochoa | Transmembrane protein 119 (Osteoblast induction factor) (OBIF) | Plays an important role in bone formation and normal bone mineralization. Promotes the differentiation of myoblasts into osteoblasts (PubMed:20025746). May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway. Up-regulates the expression of ATF4, a transcription factor which plays a central role in osteoblast differentiation. Essential for normal spermatogenesis and late testicular differentiation (By similarity). {ECO:0000250|UniProtKB:Q8R138, ECO:0000269|PubMed:20025746}. |
| Q5FWF4 | ZRANB3 | S588 | ochoa | DNA annealing helicase and endonuclease ZRANB3 (Annealing helicase 2) (AH2) (Zinc finger Ran-binding domain-containing protein 3) [Includes: DNA annealing helicase ZRANB3 (EC 3.6.4.-); Endonuclease ZRANB3 (EC 3.1.-.-)] | DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events (PubMed:21078962, PubMed:22704558, PubMed:22705370, PubMed:22759634, PubMed:26884333). Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase (PubMed:22759634). In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks (PubMed:22704558, PubMed:22705370). {ECO:0000269|PubMed:21078962, ECO:0000269|PubMed:22704558, ECO:0000269|PubMed:22705370, ECO:0000269|PubMed:22759634, ECO:0000269|PubMed:26884333}. |
| Q5JRX3 | PITRM1 | S530 | ochoa | Presequence protease, mitochondrial (hPreP) (EC 3.4.24.-) (Pitrilysin metalloproteinase 1) (Metalloprotease 1) (hMP1) | Metalloendopeptidase of the mitochondrial matrix that functions in peptide cleavage and degradation rather than in protein processing (PubMed:10360838, PubMed:16849325, PubMed:19196155, PubMed:24931469). Has an ATP-independent activity (PubMed:16849325). Specifically cleaves peptides in the range of 5 to 65 residues (PubMed:19196155). Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference (PubMed:10360838, PubMed:19196155, PubMed:24931469). Degrades the transit peptides of mitochondrial proteins after their cleavage (PubMed:19196155). Also degrades other unstructured peptides (PubMed:19196155). It is also able to degrade amyloid-beta protein 40, one of the peptides produced by APP processing, when it accumulates in mitochondrion (PubMed:16849325, PubMed:24931469, PubMed:26697887). It is a highly efficient protease, at least toward amyloid-beta protein 40 (PubMed:24931469, PubMed:29383861, PubMed:29764912). Cleaves that peptide at a specific position and is probably not processive, releasing digested peptides intermediates that can be further cleaved subsequently (PubMed:24931469). It is also able to degrade amyloid-beta protein 42 (PubMed:29764912). {ECO:0000269|PubMed:10360838, ECO:0000269|PubMed:16849325, ECO:0000269|PubMed:19196155, ECO:0000269|PubMed:24931469, ECO:0000269|PubMed:26697887, ECO:0000269|PubMed:29383861, ECO:0000269|PubMed:29764912}. |
| Q5JTV8 | TOR1AIP1 | S315 | ochoa | Torsin-1A-interacting protein 1 (Lamin-associated protein 1B) (LAP1B) | Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina. {ECO:0000269|PubMed:23569223}. |
| Q5TCX8 | MAP3K21 | S618 | ochoa | Mitogen-activated protein kinase kinase kinase 21 (EC 2.7.11.25) (Mitogen-activated protein kinase kinase kinase MLK4) (Mixed lineage kinase 4) | Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways. {ECO:0000269|PubMed:21602844}. |
| Q5TKA1 | LIN9 | S309 | ochoa|psp | Protein lin-9 homolog (HuLin-9) (hLin-9) (Beta subunit-associated regulator of apoptosis) (TUDOR gene similar protein) (Type I interferon receptor beta chain-associated protein) (pRB-associated protein) | Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition. {ECO:0000269|PubMed:15538385, ECO:0000269|PubMed:16730350}. |
| Q6NZY4 | ZCCHC8 | S557 | ochoa | Zinc finger CCHC domain-containing protein 8 (TRAMP-like complex RNA-binding factor ZCCHC8) | Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex that is involved in the surveillance and turnover of aberrant transcripts and non-coding RNAs (PubMed:27871484). NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. May be involved in pre-mRNA splicing (Probable). It is required for 3'-end maturation of telomerase RNA component (TERC), TERC 3'-end targeting to the nuclear RNA exosome, and for telomerase function (PubMed:31488579). {ECO:0000269|PubMed:27871484, ECO:0000269|PubMed:31488579, ECO:0000305|PubMed:16263084}. |
| Q6P4F7 | ARHGAP11A | S868 | ochoa | Rho GTPase-activating protein 11A (Rho-type GTPase-activating protein 11A) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000269|PubMed:27957544}. |
| Q6P4Q7 | CNNM4 | S728 | ochoa | Metal transporter CNNM4 (Ancient conserved domain-containing protein 4) (Cyclin-M4) | Probable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions (By similarity). May play a role in biomineralization and retinal function. {ECO:0000250, ECO:0000269|PubMed:19200525, ECO:0000269|PubMed:19200527}. |
| Q6PH81 | C16orf87 | S50 | ochoa | UPF0547 protein C16orf87 | None |
| Q6PJP8 | DCLRE1A | S238 | ochoa | DNA cross-link repair 1A protein (Beta-lactamase DCLRE1A) (EC 3.5.2.6) (SNM1 homolog A) (hSNM1) (hSNM1A) | May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons. Possesses beta-lactamase activity, catalyzing the hydrolysis of penicillin G and nitrocefin (PubMed:31434986). Exhibits no activity towards other beta-lactam antibiotic classes including cephalosporins (cefotaxime) and carbapenems (imipenem) (PubMed:31434986). {ECO:0000269|PubMed:15542852}. |
| Q6PJT7 | ZC3H14 | S274 | ochoa | Zinc finger CCCH domain-containing protein 14 (Mammalian suppressor of tau pathology-2) (MSUT-2) (Renal carcinoma antigen NY-REN-37) | RNA-binding protein involved in the biogenesis of circular RNAs (circRNAs), which are produced by back-splicing circularization of pre-mRNAs (PubMed:39461343). Acts by binding to both exon-intron boundary and 3'-UTR of pre-mRNAs to promote circRNA biogenesis through dimerization and the association with the spliceosome (PubMed:39461343). Required for spermatogenesis via involvement in circRNA biogenesis (PubMed:39461343). Regulates the pre-mRNA processing of ATP5MC1; preventing its degradation (PubMed:27563065). Also binds the poly(A) tail of mRNAs; controlling poly(A) length in neuronal cells (PubMed:17630287, PubMed:24671764). {ECO:0000269|PubMed:17630287, ECO:0000269|PubMed:24671764, ECO:0000269|PubMed:27563065, ECO:0000269|PubMed:39461343}. |
| Q6UB99 | ANKRD11 | S276 | ochoa | Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1) | Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). {ECO:0000250|UniProtKB:E9Q4F7, ECO:0000269|PubMed:15184363, ECO:0000269|PubMed:25556659}. |
| Q6ZN28 | MACC1 | S201 | ochoa | Metastasis-associated in colon cancer protein 1 (SH3 domain-containing protein 7a5) | Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo. {ECO:0000269|PubMed:19098908}. |
| Q7Z2K8 | GPRIN1 | S737 | ochoa | G protein-regulated inducer of neurite outgrowth 1 (GRIN1) | May be involved in neurite outgrowth. {ECO:0000250}. |
| Q7Z5J4 | RAI1 | S538 | ochoa | Retinoic acid-induced protein 1 | Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. {ECO:0000269|PubMed:22578325}. |
| Q7Z5Q1 | CPEB2 | S164 | ochoa | Cytoplasmic polyadenylation element-binding protein 2 (CPE-BP2) (CPE-binding protein 2) (hCPEB-2) | May play a role in translational regulation of stored mRNAs in transcriptionally inactive haploid spermatids. Binds to poly(U) RNA oligomers (By similarity). Required for cell cycle progression, specifically for the transition from metaphase to anaphase (PubMed:26398195). {ECO:0000250|UniProtKB:Q812E0, ECO:0000269|PubMed:26398195}. |
| Q86XL3 | ANKLE2 | S488 | ochoa | Ankyrin repeat and LEM domain-containing protein 2 (LEM domain-containing protein 4) | Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit (PubMed:22770216). Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly (PubMed:22770216). May regulate nuclear localization of VRK1 in non-dividing cells (PubMed:31735666). It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex (PubMed:22770216). Involved in brain development (PubMed:25259927). {ECO:0000269|PubMed:22770216, ECO:0000269|PubMed:25259927, ECO:0000269|PubMed:31735666}. |
| Q8IUG5 | MYO18B | S2309 | ochoa | Unconventional myosin-XVIIIb | May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth. |
| Q8IX18 | DHX40 | S197 | ochoa | Probable ATP-dependent RNA helicase DHX40 (EC 3.6.4.13) (DEAH box protein 40) (Protein PAD) | Probable ATP-dependent RNA helicase. {ECO:0000250}. |
| Q8IYW5 | RNF168 | S481 | ochoa | E3 ubiquitin-protein ligase RNF168 (hRNF168) (EC 2.3.2.27) (RING finger protein 168) (RING-type E3 ubiquitin transferase RNF168) | E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20/C1orf86 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. Following DNA damage, promotes the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF8, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Not able to initiate 'Lys-63'-linked ubiquitination in vitro; possibly due to partial occlusion of the UBE2N/UBC13-binding region. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively). {ECO:0000255|HAMAP-Rule:MF_03066, ECO:0000269|PubMed:19203578, ECO:0000269|PubMed:19203579, ECO:0000269|PubMed:20550933, ECO:0000269|PubMed:22373579, ECO:0000269|PubMed:22705371, ECO:0000269|PubMed:22713238, ECO:0000269|PubMed:22742833, ECO:0000269|PubMed:22980979, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538}. |
| Q8NEM0 | MCPH1 | S277 | ochoa | Microcephalin | Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex. {ECO:0000269|PubMed:12046007, ECO:0000269|PubMed:15199523, ECO:0000269|PubMed:15220350}. |
| Q8TER5 | ARHGEF40 | S1187 | ochoa | Rho guanine nucleotide exchange factor 40 (Protein SOLO) | May act as a guanine nucleotide exchange factor (GEF). {ECO:0000250}. |
| Q92625 | ANKS1A | S858 | ochoa | Ankyrin repeat and SAM domain-containing protein 1A (Odin) | Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity). {ECO:0000250, ECO:0000269|PubMed:17875921}. |
| Q92793 | CREBBP | S2079 | ochoa | CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-) | Acetylates histones, giving a specific tag for transcriptional activation (PubMed:21131905, PubMed:24616510). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:24207024, PubMed:28790157, PubMed:30540930, PubMed:35675826, PubMed:9707565). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as lactoyl-CoA, and is able to mediate protein lactylation (PubMed:38128537). Catalyzes lactylation of MRE11 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR) (PubMed:38128537). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000269|PubMed:10490106, ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:24616510, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:30540930, ECO:0000269|PubMed:35675826, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9707565}. |
| Q969V6 | MRTFA | S385 | ochoa | Myocardin-related transcription factor A (MRTF-A) (MKL/myocardin-like protein 1) (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein) | Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:26224645). The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus. {ECO:0000250|UniProtKB:Q8K4J6, ECO:0000269|PubMed:26224645}. |
| Q96BT3 | CENPT | S47 | ochoa|psp | Centromere protein T (CENP-T) (Interphase centromere complex protein 22) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPT has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis. {ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:21529714, ECO:0000269|PubMed:21695110}. |
| Q96E09 | PABIR1 | S48 | ochoa | PPP2R1A-PPP2R2A-interacting phosphatase regulator 1 (PABIR family member 1) | Acts as an inhibitor of serine/threonine-protein phosphatase 2A (PP2A) activity (PubMed:27588481, PubMed:33108758, PubMed:38123684). Inhibits PP2A activity by blocking the substrate binding site on PPP2R2A and the active site of PPP2CA (PubMed:38123684). Potentiates ubiquitin-mediated proteasomal degradation of serine/threonine-protein phosphatase 2A catalytic subunit alpha (PPP2CA) (PubMed:27588481). Inhibits PP2A-mediated dephosphorylation of WEE1, promoting ubiquitin-mediated proteolysis of WEE1, thereby releasing G2/M checkpoint (PubMed:33108758). {ECO:0000269|PubMed:27588481, ECO:0000269|PubMed:33108758, ECO:0000269|PubMed:38123684}. |
| Q96L73 | NSD1 | S2397 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) | Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context. {ECO:0000269|PubMed:21196496}. |
| Q96Q42 | ALS2 | S492 | ochoa|psp | Alsin (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein) (Amyotrophic lateral sclerosis 2 protein) | May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity). {ECO:0000250}. |
| Q96RG2 | PASK | S65 | ochoa | PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (hPASK) (EC 2.7.11.1) | Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation. {ECO:0000269|PubMed:16275910, ECO:0000269|PubMed:17052199, ECO:0000269|PubMed:17595531, ECO:0000269|PubMed:20943661, ECO:0000269|PubMed:21181396, ECO:0000269|PubMed:21418524}. |
| Q96SN8 | CDK5RAP2 | S1238 | ochoa | CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215) | Potential regulator of CDK5 activity via its interaction with CDK5R1 (PubMed:15164053). Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter (PubMed:19282672). Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends (PubMed:18042621, PubMed:17959831, PubMed:19553473). Regulates centrosomal maturation by recruitment of the gamma-tubulin ring complex (gTuRC) onto centrosomes (PubMed:18042621, PubMed:17959831, PubMed:26485573, PubMed:39321809). In complex with PDE4DIP isoform 13/MMG8/SMYLE, MAPRE1 and AKAP9, contributes to microtubules nucleation and extension from the centrosome to the cell periphery (PubMed:29162697). Required for the recruitment of AKAP9 to centrosomes (PubMed:29162697). Plays a role in neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q8K389, ECO:0000269|PubMed:15164053, ECO:0000269|PubMed:17959831, ECO:0000269|PubMed:18042621, ECO:0000269|PubMed:19282672, ECO:0000269|PubMed:19553473, ECO:0000269|PubMed:26485573, ECO:0000269|PubMed:29162697, ECO:0000269|PubMed:39321809}. |
| Q96T58 | SPEN | S1062 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q99081 | TCF12 | S142 | ochoa | Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) | Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250|UniProtKB:Q61286, ECO:0000269|PubMed:32620954}. |
| Q99640 | PKMYT1 | S143 | ochoa | Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase) | Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins (PubMed:10373560, PubMed:10504341, PubMed:9001210, PubMed:9268380). Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation (PubMed:9001210, PubMed:9268380). May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect (PubMed:9001210, PubMed:9268380). {ECO:0000269|PubMed:10373560, ECO:0000269|PubMed:10504341, ECO:0000269|PubMed:9001210, ECO:0000269|PubMed:9268380}. |
| Q99741 | CDC6 | S419 | ochoa | Cell division control protein 6 homolog (CDC6-related protein) (Cdc18-related protein) (HsCdc18) (p62(cdc6)) (HsCDC6) | Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. |
| Q9BWN1 | PRR14 | S29 | ochoa | Proline-rich protein 14 | Functions in tethering peripheral heterochromatin to the nuclear lamina during interphase, possibly through the interaction with heterochromatin protein CBX5/HP1 alpha (PubMed:24209742). Might play a role in reattaching heterochromatin to the nuclear lamina at mitotic exit (PubMed:24209742). Promotes myoblast differentiation during skeletal myogenesis, possibly by stimulating transcription factor MyoD activity via binding to CBX5/HP1 alpha (PubMed:25906157). Involved in the positive regulation of the PI3K-Akt-mTOR signaling pathway and in promoting cell proliferation, possibly via binding to GRB2 (PubMed:27041574). {ECO:0000269|PubMed:24209742, ECO:0000269|PubMed:25906157, ECO:0000269|PubMed:27041574}. |
| Q9BWT3 | PAPOLG | S716 | ochoa | Poly(A) polymerase gamma (PAP-gamma) (EC 2.7.7.19) (Neo-poly(A) polymerase) (Neo-PAP) (Polynucleotide adenylyltransferase gamma) (SRP RNA 3'-adenylating enzyme) (Signal recognition particle RNA-adenylating enzyme) (SRP RNA-adenylating enzyme) | Responsible for the post-transcriptional adenylation of the 3'-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA. {ECO:0000269|PubMed:11287430, ECO:0000269|PubMed:11463842}. |
| Q9C0E2 | XPO4 | S587 | ochoa | Exportin-4 (Exp4) | Mediates the nuclear export of proteins (cargos), such as EIF5A, SMAD3 and isoform M2 of PKM (PKM2) (PubMed:10944119, PubMed:16449645, PubMed:26787900). In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins (PubMed:10944119, PubMed:16449645). Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor (PubMed:10944119, PubMed:16449645). XPO4 then return to the nuclear compartment and mediate another round of transport (PubMed:10944119, PubMed:16449645). The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:10944119, PubMed:16449645). Catalyzes the nuclear export of hypusinated EIF5A; a small cytoplasmic protein that enters nucleus and accumulates within nucleolus if not exported back by XPO4 (PubMed:10944119). Specifically mediates nuclear export of isoform M2 of PKM (PKM2) following PKM2 deacetylation by SIRT6 (PubMed:26787900). Also mediates the nuclear import of SOX transcription factors SRY and SOX2 (By similarity). {ECO:0000250|UniProtKB:Q9ESJ0, ECO:0000269|PubMed:10944119, ECO:0000269|PubMed:16449645, ECO:0000269|PubMed:26787900}. |
| Q9H0M0 | WWP1 | S26 | ochoa | NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 2.3.2.26) (Atrophin-1-interacting protein 5) (AIP5) (HECT-type E3 ubiquitin transferase WWP1) (TGIF-interacting ubiquitin ligase 1) (Tiul1) (WW domain-containing protein 1) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF. Activates the Hippo signaling pathway in response to cell contact inhibition and recruitment to the Crumbs complex at the cell membrane (PubMed:34404733). Monoubiquitinates AMOTL2 which facilitates its interaction with and activation of LATS2 (PubMed:34404733). LATS2 then phosphorylates YAP1, excluding it from the nucleus and therefore ultimately represses YAP1-driven transcription of target genes (PubMed:34404733). {ECO:0000269|PubMed:12535537, ECO:0000269|PubMed:15221015, ECO:0000269|PubMed:15359284, ECO:0000269|PubMed:34404733}. |
| Q9H1H9 | KIF13A | S636 | ochoa | Kinesin-like protein KIF13A (Kinesin-like protein RBKIN) | Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR-containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abscission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis. {ECO:0000269|PubMed:19841138, ECO:0000269|PubMed:20208530}. |
| Q9H223 | EHD4 | S157 | ochoa | EH domain-containing protein 4 (Hepatocellular carcinoma-associated protein 10/11) (PAST homolog 4) | ATP- and membrane-binding protein that probably controls membrane reorganization/tubulation upon ATP hydrolysis. Plays a role in early endosomal transport (PubMed:17233914, PubMed:18331452). During sprouting angiogenesis, in complex with PACSIN2 and MICALL1, forms recycling endosome-like tubular structure at asymmetric adherens junctions to control CDH5 trafficking (By similarity). {ECO:0000250|UniProtKB:Q9EQP2, ECO:0000269|PubMed:17233914, ECO:0000269|PubMed:18331452}. |
| Q9H2M9 | RAB3GAP2 | S568 | ochoa | Rab3 GTPase-activating protein non-catalytic subunit (RGAP-iso) (Rab3 GTPase-activating protein 150 kDa subunit) (Rab3-GAP p150) (Rab3-GAP150) (Rab3-GAP regulatory subunit) | Regulatory subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of RAB3GAP1 and RAB3GAP2, which has GTPase-activating protein (GAP) activity towards various Rab3 subfamily members (RAB3A, RAB3B, RAB3C and RAB3D), RAB5A and RAB43, and guanine nucleotide exchange factor (GEF) activity towards RAB18 (PubMed:24891604, PubMed:9733780). As part of the Rab3GAP complex, acts as a GAP for Rab3 proteins by converting active RAB3-GTP to the inactive form RAB3-GDP (By similarity). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones (By similarity). The Rab3GAP complex acts as a GEF for RAB18 by promoting the conversion of inactive RAB18-GDP to the active form RAB18-GTP (PubMed:24891604). Recruits and stabilizes RAB18 at the cis-Golgi membrane in human fibroblasts where RAB18 is most likely activated (PubMed:26063829). Also involved in RAB18 recruitment at the endoplasmic reticulum (ER) membrane where it maintains proper ER structure (PubMed:24891604). Required for normal eye and brain development (By similarity). May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters (By similarity). {ECO:0000250|UniProtKB:Q15042, ECO:0000269|PubMed:24891604, ECO:0000269|PubMed:26063829, ECO:0000269|PubMed:9733780}. |
| Q9H6Q4 | CIAO3 | S214 | ochoa | Cytosolic iron-sulfur assembly component 3 (Cytosolic Fe-S cluster assembly factor NARFL) (Iron-only hydrogenase-like protein 1) (IOP1) (Nuclear prelamin A recognition factor-like protein) (Protein related to Narf) | Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect. {ECO:0000269|PubMed:16956324, ECO:0000269|PubMed:18270200}. |
| Q9H869 | YY1AP1 | S466 | ochoa | YY1-associated protein 1 (Hepatocellular carcinoma susceptibility protein) (Hepatocellular carcinoma-associated protein 2) | Associates with the INO80 chromatin remodeling complex, which is responsible for transcriptional regulation, DNA repair, and replication (PubMed:27939641). Enhances transcription activation by YY1 (PubMed:14744866). Plays a role in cell cycle regulation (PubMed:17541814, PubMed:27939641). {ECO:0000269|PubMed:14744866, ECO:0000269|PubMed:17541814, ECO:0000269|PubMed:27939641}. |
| Q9H8K7 | PAAT | S424 | ochoa | ATPase PAAT (EC 3.6.1.-) (Protein associated with ABC transporters) (PAAT) | ATPase that regulates mitochondrial ABC transporters ABCB7, ABCB8/MITOSUR and ABCB10 (PubMed:25063848). Regulates mitochondrial ferric concentration and heme biosynthesis and plays a role in the maintenance of mitochondrial homeostasis and cell survival (PubMed:25063848). {ECO:0000269|PubMed:25063848}. |
| Q9HB07 | MYG1 | S284 | ochoa | MYG1 exonuclease (EC 3.1.-.-) | 3'-5' RNA exonuclease which cleaves in situ on specific transcripts in both nucleus and mitochondrion. Involved in regulating spatially segregated organellar RNA processing, acts as a coordinator of nucleo-mitochondrial crosstalk (PubMed:31081026). In nucleolus, processes pre-ribosomal RNA involved in ribosome assembly and alters cytoplasmic translation. In mitochondrial matrix, processes 3'-termini of the mito-ribosomal and messenger RNAs and controls translation of mitochondrial proteins (Probable). {ECO:0000269|PubMed:31081026, ECO:0000305|PubMed:31081026}. |
| Q9HD20 | ATP13A1 | T946 | ochoa | Endoplasmic reticulum transmembrane helix translocase (EC 7.4.2.-) (Endoplasmic reticulum P5A-ATPase) | Endoplasmic reticulum translocase required to remove mitochondrial transmembrane proteins mistargeted to the endoplasmic reticulum (PubMed:32973005, PubMed:36264797). Acts as a dislocase that mediates the ATP-dependent extraction of mislocalized mitochondrial transmembrane proteins from the endoplasmic reticulum membrane (PubMed:32973005). Specifically binds mitochondrial tail-anchored transmembrane proteins: has an atypically large substrate-binding pocket that recognizes and binds moderately hydrophobic transmembranes with short hydrophilic lumenal domains (PubMed:32973005). {ECO:0000269|PubMed:32973005, ECO:0000269|PubMed:36264797}. |
| Q9NQW7 | XPNPEP1 | S283 | ochoa | Xaa-Pro aminopeptidase 1 (EC 3.4.11.9) (Aminoacylproline aminopeptidase) (Cytosolic aminopeptidase P) (Soluble aminopeptidase P) (sAmp) (X-Pro aminopeptidase 1) (X-prolyl aminopeptidase 1, soluble) | Metalloaminopeptidase that catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro (PubMed:11106490, PubMed:18515364, PubMed:35165443). Contributes to the degradation of bradykinin (PubMed:11106490). {ECO:0000269|PubMed:11106490, ECO:0000269|PubMed:18515364, ECO:0000269|PubMed:35165443}. |
| Q9NZJ9 | NUDT4 | S148 | ochoa | Diphosphoinositol polyphosphate phosphohydrolase 2 (DIPP-2) (EC 3.6.1.52) (Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 2) (EC 3.6.1.61) (Nucleoside diphosphate-linked moiety X motif 4) (Nudix motif 4) | Cleaves the beta-phosphate from diphosphoinositol polyphosphates such as PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 (diphosphoinositol tetrakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction (PubMed:10777568). Diadenosine polyphosphates, particularly Ap6A (P(1),P(6)-bis(5a-adenosyl) hexaphosphate) and Ap5A (P(1),P(5)-bis(5'-adenosyl) pentaphosphate) are downstream effectors of a signaling cascade that regulates cardiac KATP channels, can also be substrates, although with lower preference than the diphosphoinositol polyphosphates (PubMed:10777568). Can also catalyze the hydrolysis of 5-phosphoribose 1-diphosphate, generating the glycolytic activator ribose 1,5-bisphosphate (PubMed:12370170). Does not play a role in U8 snoRNA decapping activity (By similarity). Binds U8 snoRNA (By similarity). {ECO:0000250|UniProtKB:Q8R2U6, ECO:0000269|PubMed:10777568, ECO:0000269|PubMed:12370170}. |
| Q9UHQ1 | NARF | S196 | ochoa | Nuclear prelamin A recognition factor (Iron-only hydrogenase-like protein 2) (IOP2) | None |
| Q9UK61 | TASOR | S1552 | ochoa | Protein TASOR (CTCL tumor antigen se89-1) (Retinoblastoma-associated protein RAP140) (Transgene activation suppressor protein) | Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression (PubMed:26022416, PubMed:28581500). The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Plays a crucial role in early embryonic development (By similarity). Involved in the organization of spindle poles and spindle apparatus assembly during zygotic division (By similarity). Plays an important role in maintaining epiblast fitness or potency (By similarity). {ECO:0000250|UniProtKB:Q69ZR9, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}. |
| Q9UKM9 | RALY | S135 | ochoa|psp | RNA-binding protein Raly (Autoantigen p542) (Heterogeneous nuclear ribonucleoprotein C-like 2) (hnRNP core protein C-like 2) (hnRNP associated with lethal yellow protein homolog) | RNA-binding protein that acts as a transcriptional cofactor for cholesterol biosynthetic genes in the liver. Binds the lipid-responsive non-coding RNA LeXis and is required for LeXis-mediated effect on cholesterogenesis (By similarity). May be a heterogeneous nuclear ribonucleoprotein (hnRNP) (PubMed:9376072). {ECO:0000250|UniProtKB:Q64012, ECO:0000269|PubMed:9376072}. |
| Q9ULM3 | YEATS2 | S1043 | ochoa | YEATS domain-containing protein 2 | Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed:18838386, PubMed:19103755, PubMed:27103431). YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr) (PubMed:27103431). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:27103431). {ECO:0000269|PubMed:18838386, ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:27103431}. |
| Q9ULT8 | HECTD1 | S710 | ochoa | E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:33711283). Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion (By similarity). Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure (By similarity). Catalyzes ubiquitination and degradation of ZNF622, an assembly factor for the ribosomal 60S subunit, in hematopoietic cells, thereby promoting hematopoietic stem cell renewal (PubMed:33711283). {ECO:0000250|UniProtKB:Q69ZR2, ECO:0000269|PubMed:33711283}. |
| Q00975 | CACNA1B | S446 | SIGNOR | Voltage-dependent N-type calcium channel subunit alpha-1B (Brain calcium channel III) (BIII) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Voltage-gated calcium channel subunit alpha Cav2.2) | Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This alpha-1B subunit gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group. They are involved in pain signaling (PubMed:25296916). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons. Mediates Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals (By similarity). {ECO:0000250|UniProtKB:Q02294, ECO:0000269|PubMed:25296916}.; FUNCTION: [Isoform Alpha-1B-1]: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This alpha-1B subunit gives rise to N-type calcium currents. {ECO:0000269|PubMed:1321501}. |
| P47224 | RABIF | S39 | Sugiyama | Guanine nucleotide exchange factor MSS4 (Rab-interacting factor) | Guanine-nucleotide-releasing protein that acts on members of the SEC4/YPT1/RAB subfamily. Stimulates GDP release from both YPT1, RAB3A and RAB10, but is less active on these proteins than on the SEC4 protein (PubMed:31540829). Might play a general role in vesicular transport. {ECO:0000269|PubMed:31540829}. |
| Q6XUX3 | DSTYK | S315 | Sugiyama | Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase) (Receptor-interacting serine/threonine-protein kinase 5) (Sugen kinase 496) (SgK496) | Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation (PubMed:23862974, PubMed:28157540). Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death (PubMed:15178406). In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types (PubMed:28157540). {ECO:0000269|PubMed:15178406, ECO:0000269|PubMed:23862974, ECO:0000269|PubMed:28157540}. |
| Q9UM73 | ALK | S1075 | Sugiyama | ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246) | Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system (PubMed:11121404, PubMed:11387242, PubMed:16317043, PubMed:17274988, PubMed:30061385, PubMed:34646012, PubMed:34819673). Also acts as a key thinness protein involved in the resistance to weight gain: in hypothalamic neurons, controls energy expenditure acting as a negative regulator of white adipose tissue lipolysis and sympathetic tone to fine-tune energy homeostasis (By similarity). Following activation by ALKAL2 ligand at the cell surface, transduces an extracellular signal into an intracellular response (PubMed:30061385, PubMed:33411331, PubMed:34646012, PubMed:34819673). In contrast, ALKAL1 is not a potent physiological ligand for ALK (PubMed:34646012). Ligand-binding to the extracellular domain induces tyrosine kinase activation, leading to activation of the mitogen-activated protein kinase (MAPK) pathway (PubMed:34819673). Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif (PubMed:15226403, PubMed:16878150). Induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1 (PubMed:15226403, PubMed:16878150). ALK activation may also be regulated by pleiotrophin (PTN) and midkine (MDK) (PubMed:11278720, PubMed:11809760, PubMed:12107166, PubMed:12122009). PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation (PubMed:11278720, PubMed:11809760, PubMed:12107166). MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction (PubMed:12122009). Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase (PubMed:15226403, PubMed:16878150). Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK (PubMed:15226403, PubMed:16878150). {ECO:0000250|UniProtKB:P97793, ECO:0000269|PubMed:11121404, ECO:0000269|PubMed:11278720, ECO:0000269|PubMed:11387242, ECO:0000269|PubMed:11809760, ECO:0000269|PubMed:12107166, ECO:0000269|PubMed:12122009, ECO:0000269|PubMed:15226403, ECO:0000269|PubMed:16317043, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:17274988, ECO:0000269|PubMed:30061385, ECO:0000269|PubMed:33411331, ECO:0000269|PubMed:34646012, ECO:0000269|PubMed:34819673}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9700649 | Drug resistance of ALK mutants | 0.008349 | 2.078 |
| R-HSA-9669937 | Drug resistance of KIT mutants | 0.008349 | 2.078 |
| R-HSA-9669921 | KIT mutants bind TKIs | 0.008349 | 2.078 |
| R-HSA-9717316 | alectinib-resistant ALK mutants | 0.008349 | 2.078 |
| R-HSA-9669917 | Imatinib-resistant KIT mutants | 0.008349 | 2.078 |
| R-HSA-9669936 | Sorafenib-resistant KIT mutants | 0.008349 | 2.078 |
| R-HSA-9717323 | ceritinib-resistant ALK mutants | 0.008349 | 2.078 |
| R-HSA-9717264 | ASP-3026-resistant ALK mutants | 0.008349 | 2.078 |
| R-HSA-9717329 | lorlatinib-resistant ALK mutants | 0.008349 | 2.078 |
| R-HSA-9717326 | crizotinib-resistant ALK mutants | 0.008349 | 2.078 |
| R-HSA-9717319 | brigatinib-resistant ALK mutants | 0.008349 | 2.078 |
| R-HSA-9669914 | Dasatinib-resistant KIT mutants | 0.008349 | 2.078 |
| R-HSA-9669934 | Sunitinib-resistant KIT mutants | 0.008349 | 2.078 |
| R-HSA-9669926 | Nilotinib-resistant KIT mutants | 0.008349 | 2.078 |
| R-HSA-9669929 | Regorafenib-resistant KIT mutants | 0.008349 | 2.078 |
| R-HSA-9717301 | NVP-TAE684-resistant ALK mutants | 0.008349 | 2.078 |
| R-HSA-9669924 | Masitinib-resistant KIT mutants | 0.008349 | 2.078 |
| R-HSA-3928664 | Ephrin signaling | 0.001015 | 2.994 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.001288 | 2.890 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.001262 | 2.899 |
| R-HSA-201556 | Signaling by ALK | 0.007062 | 2.151 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 0.008180 | 2.087 |
| R-HSA-1538133 | G0 and Early G1 | 0.004178 | 2.379 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.000680 | 3.168 |
| R-HSA-186712 | Regulation of beta-cell development | 0.002573 | 2.590 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.005507 | 2.259 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.006961 | 2.157 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.005874 | 2.231 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.009839 | 2.007 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.009839 | 2.007 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.011056 | 1.956 |
| R-HSA-9708530 | Regulation of BACH1 activity | 0.012507 | 1.903 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 0.013714 | 1.863 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.016273 | 1.789 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.016273 | 1.789 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.017066 | 1.768 |
| R-HSA-9680187 | Signaling by extracellular domain mutants of KIT | 0.024839 | 1.605 |
| R-HSA-9669935 | Signaling by juxtamembrane domain KIT mutants | 0.024839 | 1.605 |
| R-HSA-9669933 | Signaling by kinase domain mutants of KIT | 0.024839 | 1.605 |
| R-HSA-1855167 | Synthesis of pyrophosphates in the cytosol | 0.025044 | 1.601 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.025041 | 1.601 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.041057 | 1.387 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.041057 | 1.387 |
| R-HSA-211163 | AKT-mediated inactivation of FOXO1A | 0.049066 | 1.309 |
| R-HSA-9818035 | NFE2L2 regulating ER-stress associated genes | 0.049066 | 1.309 |
| R-HSA-9818026 | NFE2L2 regulating inflammation associated genes | 0.057008 | 1.244 |
| R-HSA-182218 | Nef Mediated CD8 Down-regulation | 0.064884 | 1.188 |
| R-HSA-68689 | CDC6 association with the ORC:origin complex | 0.064884 | 1.188 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 0.095741 | 1.019 |
| R-HSA-9700645 | ALK mutants bind TKIs | 0.095741 | 1.019 |
| R-HSA-112308 | Presynaptic depolarization and calcium channel opening | 0.110789 | 0.956 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.118219 | 0.927 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.140142 | 0.853 |
| R-HSA-177504 | Retrograde neurotrophin signalling | 0.140142 | 0.853 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 0.154456 | 0.811 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.182378 | 0.739 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.027497 | 1.561 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.080821 | 1.092 |
| R-HSA-9669938 | Signaling by KIT in disease | 0.209384 | 0.679 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.209384 | 0.679 |
| R-HSA-6803529 | FGFR2 alternative splicing | 0.209384 | 0.679 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 0.215996 | 0.666 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 0.215996 | 0.666 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 0.215996 | 0.666 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.241900 | 0.616 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.241900 | 0.616 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.248242 | 0.605 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.248242 | 0.605 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.248242 | 0.605 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.248242 | 0.605 |
| R-HSA-1989781 | PPARA activates gene expression | 0.058567 | 1.232 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.326052 | 0.487 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.105128 | 0.978 |
| R-HSA-72172 | mRNA Splicing | 0.120212 | 0.920 |
| R-HSA-167169 | HIV Transcription Elongation | 0.326052 | 0.487 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 0.132895 | 0.876 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.060565 | 1.218 |
| R-HSA-72086 | mRNA Capping | 0.254532 | 0.594 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.046928 | 1.329 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.326052 | 0.487 |
| R-HSA-8983432 | Interleukin-15 signaling | 0.125588 | 0.901 |
| R-HSA-9831926 | Nephron development | 0.175484 | 0.756 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 0.202717 | 0.693 |
| R-HSA-9020958 | Interleukin-21 signaling | 0.095741 | 1.019 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.320362 | 0.494 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.235546 | 0.628 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.235505 | 0.628 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.260769 | 0.584 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.161524 | 0.792 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.326052 | 0.487 |
| R-HSA-9020558 | Interleukin-2 signaling | 0.110789 | 0.956 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.074645 | 1.127 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.074645 | 1.127 |
| R-HSA-9851151 | MDK and PTN in ALK signaling | 0.049066 | 1.309 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.125588 | 0.901 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.153717 | 0.813 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 0.175484 | 0.756 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.326052 | 0.487 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.326052 | 0.487 |
| R-HSA-8985947 | Interleukin-9 signaling | 0.088123 | 1.055 |
| R-HSA-9636249 | Inhibition of nitric oxide production | 0.041057 | 1.387 |
| R-HSA-167590 | Nef Mediated CD4 Down-regulation | 0.080441 | 1.095 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 0.110789 | 0.956 |
| R-HSA-9930044 | Nuclear RNA decay | 0.042919 | 1.367 |
| R-HSA-3000157 | Laminin interactions | 0.229056 | 0.640 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.148282 | 0.829 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.326052 | 0.487 |
| R-HSA-9843745 | Adipogenesis | 0.126826 | 0.897 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 0.118219 | 0.927 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.202717 | 0.693 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.285204 | 0.545 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.057581 | 1.240 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.226307 | 0.645 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.242850 | 0.615 |
| R-HSA-69478 | G2/M DNA replication checkpoint | 0.072695 | 1.138 |
| R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 0.103296 | 0.986 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 0.118219 | 0.927 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 0.125588 | 0.901 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 0.046928 | 1.329 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.175484 | 0.756 |
| R-HSA-8851708 | Signaling by FGFR2 IIIa TM | 0.182378 | 0.739 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.209384 | 0.679 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.090836 | 1.042 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.266955 | 0.574 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.285204 | 0.545 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.308837 | 0.510 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.171875 | 0.765 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.269559 | 0.569 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.169827 | 0.770 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.248283 | 0.605 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 0.088123 | 1.055 |
| R-HSA-4641258 | Degradation of DVL | 0.308837 | 0.510 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.244808 | 0.611 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 0.088123 | 1.055 |
| R-HSA-9937080 | Developmental Lineage of Multipotent Pancreatic Progenitor Cells | 0.040966 | 1.388 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 0.154456 | 0.811 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 0.168533 | 0.773 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.229056 | 0.640 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.069780 | 1.156 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.214033 | 0.670 |
| R-HSA-210747 | Regulation of gene expression in early pancreatic precursor cells | 0.110789 | 0.956 |
| R-HSA-5635838 | Activation of SMO | 0.154456 | 0.811 |
| R-HSA-2564830 | Cytosolic iron-sulfur cluster assembly | 0.175484 | 0.756 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.066517 | 1.177 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.260769 | 0.584 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.073159 | 1.136 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 0.165815 | 0.780 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.320362 | 0.494 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.090674 | 1.043 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.308837 | 0.510 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 0.215996 | 0.666 |
| R-HSA-69306 | DNA Replication | 0.173930 | 0.760 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 0.072695 | 1.138 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.189214 | 0.723 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.279172 | 0.554 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.050023 | 1.301 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.161524 | 0.792 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.266955 | 0.574 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 0.279172 | 0.554 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.145398 | 0.837 |
| R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 0.095741 | 1.019 |
| R-HSA-198693 | AKT phosphorylates targets in the nucleus | 0.095741 | 1.019 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 0.103296 | 0.986 |
| R-HSA-9839394 | TGFBR3 expression | 0.229056 | 0.640 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 0.254532 | 0.594 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.139667 | 0.855 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.145398 | 0.837 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.326052 | 0.487 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.326052 | 0.487 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.217096 | 0.663 |
| R-HSA-69206 | G1/S Transition | 0.030868 | 1.510 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.095146 | 1.022 |
| R-HSA-69275 | G2/M Transition | 0.247218 | 0.607 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.251687 | 0.599 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.106488 | 0.973 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.061959 | 1.208 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.279172 | 0.554 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.279172 | 0.554 |
| R-HSA-69239 | Synthesis of DNA | 0.263368 | 0.579 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.033181 | 1.479 |
| R-HSA-69481 | G2/M Checkpoints | 0.117675 | 0.929 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.057008 | 1.244 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 0.147329 | 0.832 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.057513 | 1.240 |
| R-HSA-8874081 | MET activates PTK2 signaling | 0.235505 | 0.628 |
| R-HSA-3214847 | HATs acetylate histones | 0.065934 | 1.181 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.273089 | 0.564 |
| R-HSA-3371568 | Attenuation phase | 0.326052 | 0.487 |
| R-HSA-69242 | S Phase | 0.163728 | 0.786 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.059524 | 1.225 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.142526 | 0.846 |
| R-HSA-422475 | Axon guidance | 0.198437 | 0.702 |
| R-HSA-373760 | L1CAM interactions | 0.096811 | 1.014 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 0.154456 | 0.811 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.222554 | 0.653 |
| R-HSA-1640170 | Cell Cycle | 0.043450 | 1.362 |
| R-HSA-9637687 | Suppression of phagosomal maturation | 0.235505 | 0.628 |
| R-HSA-3000178 | ECM proteoglycans | 0.142526 | 0.846 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.114567 | 0.941 |
| R-HSA-9675108 | Nervous system development | 0.243234 | 0.614 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.161524 | 0.792 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.266955 | 0.574 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.266464 | 0.574 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.158291 | 0.801 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.229056 | 0.640 |
| R-HSA-8964038 | LDL clearance | 0.209384 | 0.679 |
| R-HSA-1266738 | Developmental Biology | 0.291288 | 0.536 |
| R-HSA-525793 | Myogenesis | 0.235505 | 0.628 |
| R-HSA-9638630 | Attachment of bacteria to epithelial cells | 0.235505 | 0.628 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.205700 | 0.687 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 0.320362 | 0.494 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.260769 | 0.584 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.294478 | 0.531 |
| R-HSA-73886 | Chromosome Maintenance | 0.312789 | 0.505 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.321996 | 0.492 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 0.154456 | 0.811 |
| R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 0.229056 | 0.640 |
| R-HSA-203927 | MicroRNA (miRNA) biogenesis | 0.229056 | 0.640 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 0.195994 | 0.708 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.195994 | 0.708 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.260769 | 0.584 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.151177 | 0.821 |
| R-HSA-9833110 | RSV-host interactions | 0.254084 | 0.595 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.041389 | 1.383 |
| R-HSA-419037 | NCAM1 interactions | 0.308837 | 0.510 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.240539 | 0.619 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.186696 | 0.729 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.303555 | 0.518 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.063567 | 1.197 |
| R-HSA-9931953 | Biofilm formation | 0.314624 | 0.502 |
| R-HSA-8854691 | Interleukin-20 family signaling | 0.215996 | 0.666 |
| R-HSA-111933 | Calmodulin induced events | 0.303003 | 0.519 |
| R-HSA-5620971 | Pyroptosis | 0.248242 | 0.605 |
| R-HSA-111997 | CaM pathway | 0.303003 | 0.519 |
| R-HSA-8875878 | MET promotes cell motility | 0.314624 | 0.502 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.241900 | 0.616 |
| R-HSA-9707616 | Heme signaling | 0.117295 | 0.931 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.030003 | 1.523 |
| R-HSA-4839726 | Chromatin organization | 0.076932 | 1.114 |
| R-HSA-162592 | Integration of provirus | 0.118219 | 0.927 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.308837 | 0.510 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.278844 | 0.555 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.036311 | 1.440 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 0.229056 | 0.640 |
| R-HSA-195721 | Signaling by WNT | 0.277675 | 0.556 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.306636 | 0.513 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.139667 | 0.855 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.031255 | 1.505 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.279172 | 0.554 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.300473 | 0.522 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.215996 | 0.666 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.291187 | 0.536 |
| R-HSA-1839126 | FGFR2 mutant receptor activation | 0.303003 | 0.519 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 0.182378 | 0.739 |
| R-HSA-8982491 | Glycogen metabolism | 0.326052 | 0.487 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 0.031736 | 1.498 |
| R-HSA-8948216 | Collagen chain trimerization | 0.308837 | 0.510 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 0.291187 | 0.536 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.204871 | 0.689 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 0.195994 | 0.708 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.065934 | 1.181 |
| R-HSA-73887 | Death Receptor Signaling | 0.175991 | 0.755 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.328119 | 0.484 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.328119 | 0.484 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.328119 | 0.484 |
| R-HSA-162582 | Signal Transduction | 0.328420 | 0.484 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.331695 | 0.479 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.337274 | 0.472 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.337291 | 0.472 |
| R-HSA-167161 | HIV Transcription Initiation | 0.337291 | 0.472 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.337291 | 0.472 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.337291 | 0.472 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.337291 | 0.472 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.337291 | 0.472 |
| R-HSA-189451 | Heme biosynthesis | 0.337291 | 0.472 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.340319 | 0.468 |
| R-HSA-162906 | HIV Infection | 0.342604 | 0.465 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.342841 | 0.465 |
| R-HSA-111996 | Ca-dependent events | 0.342841 | 0.465 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.348344 | 0.458 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.348344 | 0.458 |
| R-HSA-73621 | Pyrimidine catabolism | 0.348344 | 0.458 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 0.348344 | 0.458 |
| R-HSA-9909396 | Circadian clock | 0.352451 | 0.453 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.353802 | 0.451 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.353802 | 0.451 |
| R-HSA-69236 | G1 Phase | 0.353802 | 0.451 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.359214 | 0.445 |
| R-HSA-774815 | Nucleosome assembly | 0.359214 | 0.445 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.359214 | 0.445 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.359214 | 0.445 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.359214 | 0.445 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.364581 | 0.438 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.364581 | 0.438 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.364581 | 0.438 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.364581 | 0.438 |
| R-HSA-75153 | Apoptotic execution phase | 0.364581 | 0.438 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.367507 | 0.435 |
| R-HSA-437239 | Recycling pathway of L1 | 0.369904 | 0.432 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.369904 | 0.432 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.370503 | 0.431 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.375183 | 0.426 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.380417 | 0.420 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.385608 | 0.414 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.390756 | 0.408 |
| R-HSA-73894 | DNA Repair | 0.394792 | 0.404 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.395861 | 0.402 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.395861 | 0.402 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.395861 | 0.402 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.400924 | 0.397 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.400924 | 0.397 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.405944 | 0.392 |
| R-HSA-166520 | Signaling by NTRKs | 0.405988 | 0.391 |
| R-HSA-5688426 | Deubiquitination | 0.406106 | 0.391 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.410923 | 0.386 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.410923 | 0.386 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.411812 | 0.385 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.415860 | 0.381 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.420496 | 0.376 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.425612 | 0.371 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.430427 | 0.366 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.430427 | 0.366 |
| R-HSA-162587 | HIV Life Cycle | 0.431972 | 0.365 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.435036 | 0.361 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.435202 | 0.361 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.435202 | 0.361 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.435202 | 0.361 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.435202 | 0.361 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.435202 | 0.361 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.435202 | 0.361 |
| R-HSA-877300 | Interferon gamma signaling | 0.437666 | 0.359 |
| R-HSA-68886 | M Phase | 0.437998 | 0.359 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.439859 | 0.357 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.439937 | 0.357 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.439937 | 0.357 |
| R-HSA-112043 | PLC beta mediated events | 0.439937 | 0.357 |
| R-HSA-1442490 | Collagen degradation | 0.439937 | 0.357 |
| R-HSA-1268020 | Mitochondrial protein import | 0.444633 | 0.352 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.444633 | 0.352 |
| R-HSA-186797 | Signaling by PDGF | 0.444633 | 0.352 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.449290 | 0.347 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.449290 | 0.347 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.449290 | 0.347 |
| R-HSA-373755 | Semaphorin interactions | 0.449290 | 0.347 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.453908 | 0.343 |
| R-HSA-449147 | Signaling by Interleukins | 0.458051 | 0.339 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.458488 | 0.339 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.463029 | 0.334 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.463029 | 0.334 |
| R-HSA-9830369 | Kidney development | 0.467533 | 0.330 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.467533 | 0.330 |
| R-HSA-112040 | G-protein mediated events | 0.467533 | 0.330 |
| R-HSA-167172 | Transcription of the HIV genome | 0.471999 | 0.326 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 0.471999 | 0.326 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.471999 | 0.326 |
| R-HSA-5218859 | Regulated Necrosis | 0.471999 | 0.326 |
| R-HSA-418555 | G alpha (s) signalling events | 0.473902 | 0.324 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.479354 | 0.319 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.480820 | 0.318 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.485175 | 0.314 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.485175 | 0.314 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.485175 | 0.314 |
| R-HSA-189445 | Metabolism of porphyrins | 0.485175 | 0.314 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.489495 | 0.310 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.489495 | 0.310 |
| R-HSA-199991 | Membrane Trafficking | 0.491782 | 0.308 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.493778 | 0.306 |
| R-HSA-168255 | Influenza Infection | 0.495500 | 0.305 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.498025 | 0.303 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.498025 | 0.303 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.498025 | 0.303 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.498025 | 0.303 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.502238 | 0.299 |
| R-HSA-380287 | Centrosome maturation | 0.502238 | 0.299 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.502238 | 0.299 |
| R-HSA-8852135 | Protein ubiquitination | 0.502238 | 0.299 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.502238 | 0.299 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.502238 | 0.299 |
| R-HSA-74160 | Gene expression (Transcription) | 0.505919 | 0.296 |
| R-HSA-5689603 | UCH proteinases | 0.506415 | 0.295 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.506415 | 0.295 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.514665 | 0.288 |
| R-HSA-4086400 | PCP/CE pathway | 0.514665 | 0.288 |
| R-HSA-216083 | Integrin cell surface interactions | 0.514665 | 0.288 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.518739 | 0.285 |
| R-HSA-983712 | Ion channel transport | 0.521700 | 0.283 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.522778 | 0.282 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.522778 | 0.282 |
| R-HSA-6806834 | Signaling by MET | 0.522778 | 0.282 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.526784 | 0.278 |
| R-HSA-68877 | Mitotic Prometaphase | 0.531926 | 0.274 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.534696 | 0.272 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.538603 | 0.269 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.538603 | 0.269 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.542477 | 0.266 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.546319 | 0.263 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.546319 | 0.263 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.549462 | 0.260 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.550129 | 0.260 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.553907 | 0.257 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.557653 | 0.254 |
| R-HSA-212436 | Generic Transcription Pathway | 0.563997 | 0.249 |
| R-HSA-5357801 | Programmed Cell Death | 0.564127 | 0.249 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.565053 | 0.248 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.568707 | 0.245 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.573199 | 0.242 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.575923 | 0.240 |
| R-HSA-391251 | Protein folding | 0.575923 | 0.240 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.583019 | 0.234 |
| R-HSA-1474290 | Collagen formation | 0.583019 | 0.234 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.583148 | 0.234 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.586523 | 0.232 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.587176 | 0.231 |
| R-HSA-68882 | Mitotic Anaphase | 0.590123 | 0.229 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.592429 | 0.227 |
| R-HSA-418990 | Adherens junctions interactions | 0.594726 | 0.226 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.596495 | 0.224 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.596860 | 0.224 |
| R-HSA-157579 | Telomere Maintenance | 0.596860 | 0.224 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.600248 | 0.222 |
| R-HSA-190236 | Signaling by FGFR | 0.600248 | 0.222 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.600248 | 0.222 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.600248 | 0.222 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.606940 | 0.217 |
| R-HSA-70171 | Glycolysis | 0.606940 | 0.217 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.610245 | 0.214 |
| R-HSA-111885 | Opioid Signalling | 0.619993 | 0.208 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.626357 | 0.203 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.626357 | 0.203 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.632615 | 0.199 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.632615 | 0.199 |
| R-HSA-211000 | Gene Silencing by RNA | 0.632615 | 0.199 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.635705 | 0.197 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.635705 | 0.197 |
| R-HSA-8939211 | ESR-mediated signaling | 0.636537 | 0.196 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.638769 | 0.195 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.638769 | 0.195 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.641808 | 0.193 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.641808 | 0.193 |
| R-HSA-6803157 | Antimicrobial peptides | 0.644821 | 0.191 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.650772 | 0.187 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.650772 | 0.187 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.653710 | 0.185 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.659513 | 0.181 |
| R-HSA-913531 | Interferon Signaling | 0.661153 | 0.180 |
| R-HSA-421270 | Cell-cell junction organization | 0.665150 | 0.177 |
| R-HSA-70326 | Glucose metabolism | 0.668038 | 0.175 |
| R-HSA-5693538 | Homology Directed Repair | 0.670832 | 0.173 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.673603 | 0.172 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.673603 | 0.172 |
| R-HSA-68875 | Mitotic Prophase | 0.676350 | 0.170 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.679075 | 0.168 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.679075 | 0.168 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 0.679075 | 0.168 |
| R-HSA-3371556 | Cellular response to heat stress | 0.679075 | 0.168 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.681777 | 0.166 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.681777 | 0.166 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.684456 | 0.165 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.684456 | 0.165 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.684456 | 0.165 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.690223 | 0.161 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.699538 | 0.155 |
| R-HSA-8956319 | Nucleotide catabolism | 0.702594 | 0.153 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.705100 | 0.152 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.712491 | 0.147 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.712491 | 0.147 |
| R-HSA-446728 | Cell junction organization | 0.715223 | 0.146 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.724402 | 0.140 |
| R-HSA-8953854 | Metabolism of RNA | 0.728448 | 0.138 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.729029 | 0.137 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.733765 | 0.134 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.740260 | 0.131 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.740260 | 0.131 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.743444 | 0.129 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.745028 | 0.128 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.753129 | 0.123 |
| R-HSA-9758941 | Gastrulation | 0.755211 | 0.122 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.761355 | 0.118 |
| R-HSA-9609507 | Protein localization | 0.763368 | 0.117 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.765365 | 0.116 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.767345 | 0.115 |
| R-HSA-1500931 | Cell-Cell communication | 0.774996 | 0.111 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.776999 | 0.110 |
| R-HSA-109581 | Apoptosis | 0.780748 | 0.107 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.784435 | 0.105 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.784741 | 0.105 |
| R-HSA-1474244 | Extracellular matrix organization | 0.795426 | 0.099 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.798576 | 0.098 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.800278 | 0.097 |
| R-HSA-388396 | GPCR downstream signalling | 0.801227 | 0.096 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.801965 | 0.096 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.801965 | 0.096 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.805297 | 0.094 |
| R-HSA-5617833 | Cilium Assembly | 0.828578 | 0.082 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.830028 | 0.081 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.833642 | 0.079 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.837097 | 0.077 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.842541 | 0.074 |
| R-HSA-9640148 | Infection with Enterobacteria | 0.846506 | 0.072 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.859018 | 0.066 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.861702 | 0.065 |
| R-HSA-372790 | Signaling by GPCR | 0.864692 | 0.063 |
| R-HSA-9679506 | SARS-CoV Infections | 0.864940 | 0.063 |
| R-HSA-8951664 | Neddylation | 0.869411 | 0.061 |
| R-HSA-168256 | Immune System | 0.869727 | 0.061 |
| R-HSA-2262752 | Cellular responses to stress | 0.873968 | 0.059 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.876966 | 0.057 |
| R-HSA-15869 | Metabolism of nucleotides | 0.885069 | 0.053 |
| R-HSA-157118 | Signaling by NOTCH | 0.888920 | 0.051 |
| R-HSA-1280218 | Adaptive Immune System | 0.889213 | 0.051 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.903084 | 0.044 |
| R-HSA-416476 | G alpha (q) signalling events | 0.909479 | 0.041 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.911000 | 0.040 |
| R-HSA-6798695 | Neutrophil degranulation | 0.912220 | 0.040 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.916946 | 0.038 |
| R-HSA-112316 | Neuronal System | 0.918656 | 0.037 |
| R-HSA-9824446 | Viral Infection Pathways | 0.924864 | 0.034 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.931280 | 0.031 |
| R-HSA-8957322 | Metabolism of steroids | 0.945806 | 0.024 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.956261 | 0.019 |
| R-HSA-418594 | G alpha (i) signalling events | 0.973661 | 0.012 |
| R-HSA-168249 | Innate Immune System | 0.973909 | 0.011 |
| R-HSA-597592 | Post-translational protein modification | 0.975835 | 0.011 |
| R-HSA-382551 | Transport of small molecules | 0.991481 | 0.004 |
| R-HSA-5663205 | Infectious disease | 0.991514 | 0.004 |
| R-HSA-392499 | Metabolism of proteins | 0.994560 | 0.002 |
| R-HSA-1643685 | Disease | 0.997083 | 0.001 |
| R-HSA-109582 | Hemostasis | 0.999015 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999055 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CDK18 |
0.845 | 0.746 | 1 | 0.855 |
KIS |
0.842 | 0.673 | 1 | 0.795 |
CDK17 |
0.841 | 0.756 | 1 | 0.871 |
CDK16 |
0.839 | 0.742 | 1 | 0.867 |
CDK19 |
0.835 | 0.703 | 1 | 0.828 |
P38G |
0.834 | 0.757 | 1 | 0.876 |
CDK13 |
0.834 | 0.738 | 1 | 0.834 |
CDK7 |
0.834 | 0.709 | 1 | 0.821 |
CDK8 |
0.831 | 0.704 | 1 | 0.801 |
JNK2 |
0.831 | 0.766 | 1 | 0.843 |
CDK12 |
0.830 | 0.735 | 1 | 0.844 |
HIPK2 |
0.830 | 0.666 | 1 | 0.835 |
ERK1 |
0.829 | 0.720 | 1 | 0.837 |
CDK14 |
0.829 | 0.737 | 1 | 0.815 |
CDK10 |
0.827 | 0.699 | 1 | 0.831 |
CDK1 |
0.827 | 0.707 | 1 | 0.834 |
CDK3 |
0.827 | 0.644 | 1 | 0.875 |
CDK5 |
0.827 | 0.698 | 1 | 0.798 |
CDK9 |
0.826 | 0.721 | 1 | 0.825 |
P38D |
0.824 | 0.737 | 1 | 0.886 |
P38B |
0.822 | 0.715 | 1 | 0.828 |
DYRK2 |
0.821 | 0.652 | 1 | 0.762 |
JNK3 |
0.821 | 0.745 | 1 | 0.829 |
ERK2 |
0.821 | 0.730 | 1 | 0.789 |
P38A |
0.820 | 0.706 | 1 | 0.770 |
NLK |
0.817 | 0.671 | 1 | 0.578 |
HIPK1 |
0.816 | 0.614 | 1 | 0.747 |
DYRK1B |
0.816 | 0.644 | 1 | 0.809 |
CDK4 |
0.815 | 0.722 | 1 | 0.851 |
DYRK4 |
0.813 | 0.657 | 1 | 0.849 |
CDK6 |
0.813 | 0.704 | 1 | 0.832 |
SRPK1 |
0.812 | 0.347 | -3 | 0.751 |
HIPK4 |
0.811 | 0.417 | 1 | 0.566 |
CLK3 |
0.811 | 0.411 | 1 | 0.554 |
HIPK3 |
0.810 | 0.610 | 1 | 0.714 |
ERK5 |
0.808 | 0.375 | 1 | 0.524 |
CDK2 |
0.807 | 0.553 | 1 | 0.725 |
DYRK1A |
0.807 | 0.542 | 1 | 0.728 |
CLK1 |
0.804 | 0.397 | -3 | 0.710 |
SRPK2 |
0.802 | 0.287 | -3 | 0.678 |
JNK1 |
0.802 | 0.668 | 1 | 0.853 |
DYRK3 |
0.799 | 0.488 | 1 | 0.710 |
CDKL5 |
0.796 | 0.172 | -3 | 0.790 |
CLK4 |
0.795 | 0.344 | -3 | 0.740 |
CDKL1 |
0.793 | 0.165 | -3 | 0.798 |
ICK |
0.793 | 0.319 | -3 | 0.818 |
SRPK3 |
0.793 | 0.266 | -3 | 0.732 |
MTOR |
0.792 | 0.164 | 1 | 0.365 |
PRKD1 |
0.790 | 0.136 | -3 | 0.778 |
CLK2 |
0.788 | 0.358 | -3 | 0.726 |
CDC7 |
0.787 | -0.077 | 1 | 0.278 |
MOS |
0.784 | -0.020 | 1 | 0.331 |
MAK |
0.784 | 0.424 | -2 | 0.652 |
COT |
0.784 | -0.116 | 2 | 0.869 |
PRKD2 |
0.784 | 0.104 | -3 | 0.716 |
MOK |
0.784 | 0.418 | 1 | 0.658 |
CAMK1B |
0.781 | 0.035 | -3 | 0.831 |
PRP4 |
0.781 | 0.391 | -3 | 0.741 |
NUAK2 |
0.781 | 0.064 | -3 | 0.788 |
PRPK |
0.780 | -0.115 | -1 | 0.825 |
PKN3 |
0.779 | 0.006 | -3 | 0.787 |
PRKD3 |
0.779 | 0.120 | -3 | 0.707 |
WNK1 |
0.779 | -0.016 | -2 | 0.839 |
MST4 |
0.779 | -0.005 | 2 | 0.848 |
BMPR2 |
0.775 | -0.149 | -2 | 0.839 |
PDHK4 |
0.775 | -0.163 | 1 | 0.274 |
TBK1 |
0.774 | -0.181 | 1 | 0.158 |
ERK7 |
0.774 | 0.238 | 2 | 0.543 |
PIM3 |
0.774 | -0.051 | -3 | 0.799 |
ATR |
0.774 | -0.072 | 1 | 0.257 |
GCN2 |
0.774 | -0.197 | 2 | 0.789 |
NIK |
0.774 | -0.008 | -3 | 0.831 |
TSSK2 |
0.774 | 0.067 | -5 | 0.786 |
IRE1 |
0.774 | -0.026 | 1 | 0.198 |
NDR2 |
0.772 | -0.063 | -3 | 0.782 |
PIM1 |
0.772 | 0.037 | -3 | 0.752 |
NUAK1 |
0.772 | 0.043 | -3 | 0.732 |
TSSK1 |
0.772 | 0.055 | -3 | 0.813 |
MAPKAPK3 |
0.772 | 0.017 | -3 | 0.719 |
TGFBR2 |
0.772 | -0.078 | -2 | 0.743 |
PDHK1 |
0.772 | -0.155 | 1 | 0.245 |
PKN2 |
0.771 | -0.015 | -3 | 0.784 |
AMPKA1 |
0.771 | -0.016 | -3 | 0.793 |
DSTYK |
0.770 | -0.156 | 2 | 0.867 |
P90RSK |
0.770 | 0.010 | -3 | 0.754 |
NDR1 |
0.770 | -0.060 | -3 | 0.779 |
RAF1 |
0.770 | -0.214 | 1 | 0.204 |
ULK2 |
0.770 | -0.191 | 2 | 0.800 |
CAMLCK |
0.769 | -0.024 | -2 | 0.787 |
RIPK3 |
0.769 | -0.122 | 3 | 0.802 |
PKCD |
0.769 | -0.011 | 2 | 0.791 |
DAPK2 |
0.768 | -0.032 | -3 | 0.830 |
RSK2 |
0.768 | -0.007 | -3 | 0.751 |
RSK3 |
0.767 | -0.018 | -3 | 0.743 |
AMPKA2 |
0.766 | -0.006 | -3 | 0.759 |
IKKE |
0.766 | -0.206 | 1 | 0.154 |
NEK6 |
0.766 | -0.114 | -2 | 0.818 |
MAPKAPK2 |
0.766 | 0.019 | -3 | 0.688 |
CHAK2 |
0.766 | -0.058 | -1 | 0.877 |
PHKG1 |
0.765 | -0.017 | -3 | 0.766 |
WNK3 |
0.765 | -0.182 | 1 | 0.195 |
IRE2 |
0.765 | -0.048 | 2 | 0.770 |
BCKDK |
0.765 | -0.133 | -1 | 0.823 |
NIM1 |
0.765 | -0.054 | 3 | 0.803 |
MELK |
0.764 | -0.010 | -3 | 0.744 |
CAMK4 |
0.763 | -0.047 | -3 | 0.760 |
IKKB |
0.763 | -0.216 | -2 | 0.701 |
NEK7 |
0.763 | -0.195 | -3 | 0.773 |
SKMLCK |
0.763 | -0.092 | -2 | 0.808 |
CAMK2G |
0.763 | -0.129 | 2 | 0.780 |
CHK1 |
0.763 | 0.072 | -3 | 0.750 |
RIPK1 |
0.763 | -0.141 | 1 | 0.181 |
LATS2 |
0.763 | -0.064 | -5 | 0.616 |
MLK1 |
0.762 | -0.159 | 2 | 0.811 |
MNK2 |
0.762 | -0.016 | -2 | 0.743 |
BUB1 |
0.762 | 0.201 | -5 | 0.835 |
MARK4 |
0.762 | -0.074 | 4 | 0.785 |
P70S6KB |
0.761 | -0.031 | -3 | 0.760 |
CAMK2D |
0.761 | -0.057 | -3 | 0.790 |
HUNK |
0.761 | -0.158 | 2 | 0.808 |
PKR |
0.760 | -0.062 | 1 | 0.231 |
ATM |
0.760 | -0.081 | 1 | 0.210 |
PINK1 |
0.760 | 0.140 | 1 | 0.424 |
GRK5 |
0.760 | -0.176 | -3 | 0.849 |
QIK |
0.759 | -0.040 | -3 | 0.775 |
MASTL |
0.759 | -0.190 | -2 | 0.765 |
PKACG |
0.759 | -0.050 | -2 | 0.694 |
SMG1 |
0.759 | -0.058 | 1 | 0.235 |
MPSK1 |
0.759 | 0.043 | 1 | 0.296 |
ULK1 |
0.759 | -0.183 | -3 | 0.764 |
ANKRD3 |
0.758 | -0.161 | 1 | 0.218 |
AURC |
0.758 | -0.024 | -2 | 0.603 |
PKCB |
0.758 | -0.020 | 2 | 0.736 |
ALK4 |
0.758 | -0.068 | -2 | 0.784 |
BMPR1B |
0.758 | -0.065 | 1 | 0.226 |
PKCA |
0.758 | -0.020 | 2 | 0.733 |
NEK9 |
0.757 | -0.183 | 2 | 0.840 |
CAMK1G |
0.757 | 0.015 | -3 | 0.730 |
PKCZ |
0.757 | -0.036 | 2 | 0.789 |
AKT2 |
0.757 | 0.035 | -3 | 0.668 |
VRK2 |
0.756 | -0.005 | 1 | 0.313 |
PIM2 |
0.756 | 0.021 | -3 | 0.718 |
MNK1 |
0.756 | -0.018 | -2 | 0.755 |
PKCG |
0.756 | -0.038 | 2 | 0.729 |
TGFBR1 |
0.755 | -0.070 | -2 | 0.763 |
MLK2 |
0.755 | -0.161 | 2 | 0.830 |
DNAPK |
0.755 | -0.053 | 1 | 0.197 |
PHKG2 |
0.755 | -0.017 | -3 | 0.742 |
GRK6 |
0.754 | -0.144 | 1 | 0.213 |
DLK |
0.754 | -0.211 | 1 | 0.203 |
SIK |
0.754 | -0.017 | -3 | 0.709 |
MEK1 |
0.754 | -0.123 | 2 | 0.836 |
MYLK4 |
0.753 | -0.028 | -2 | 0.713 |
MSK2 |
0.753 | -0.043 | -3 | 0.728 |
PKCH |
0.753 | -0.042 | 2 | 0.726 |
IRAK4 |
0.753 | -0.068 | 1 | 0.175 |
MAPKAPK5 |
0.753 | -0.026 | -3 | 0.695 |
WNK4 |
0.753 | -0.065 | -2 | 0.825 |
AURB |
0.753 | -0.038 | -2 | 0.595 |
CHAK1 |
0.752 | -0.110 | 2 | 0.798 |
PAK6 |
0.752 | -0.036 | -2 | 0.631 |
LATS1 |
0.752 | -0.053 | -3 | 0.798 |
QSK |
0.752 | -0.035 | 4 | 0.767 |
HRI |
0.751 | -0.105 | -2 | 0.798 |
MLK3 |
0.751 | -0.088 | 2 | 0.735 |
SGK3 |
0.751 | -0.019 | -3 | 0.716 |
ACVR2A |
0.750 | -0.093 | -2 | 0.741 |
NEK2 |
0.750 | -0.132 | 2 | 0.820 |
IKKA |
0.750 | -0.162 | -2 | 0.696 |
PAK3 |
0.749 | -0.113 | -2 | 0.717 |
PKCT |
0.749 | -0.030 | 2 | 0.741 |
ACVR2B |
0.748 | -0.105 | -2 | 0.754 |
PKN1 |
0.748 | 0.029 | -3 | 0.690 |
PKG2 |
0.748 | -0.032 | -2 | 0.634 |
CAMK2B |
0.748 | -0.048 | 2 | 0.743 |
GRK1 |
0.748 | -0.109 | -2 | 0.731 |
DCAMKL1 |
0.748 | -0.031 | -3 | 0.721 |
YSK4 |
0.748 | -0.179 | 1 | 0.169 |
PKCI |
0.748 | 0.002 | 2 | 0.752 |
SBK |
0.748 | 0.146 | -3 | 0.557 |
FAM20C |
0.748 | -0.040 | 2 | 0.578 |
TTBK2 |
0.747 | -0.213 | 2 | 0.691 |
DCAMKL2 |
0.747 | -0.015 | -3 | 0.745 |
AKT1 |
0.747 | 0.014 | -3 | 0.669 |
PLK4 |
0.747 | -0.119 | 2 | 0.648 |
CAMK2A |
0.747 | -0.022 | 2 | 0.748 |
CHK2 |
0.747 | 0.063 | -3 | 0.609 |
PERK |
0.747 | -0.128 | -2 | 0.780 |
SMMLCK |
0.747 | -0.014 | -3 | 0.789 |
PAK1 |
0.746 | -0.103 | -2 | 0.714 |
PKACB |
0.746 | -0.021 | -2 | 0.629 |
RSK4 |
0.745 | -0.031 | -3 | 0.711 |
GRK7 |
0.745 | -0.059 | 1 | 0.232 |
BRSK2 |
0.745 | -0.092 | -3 | 0.751 |
MST3 |
0.745 | -0.045 | 2 | 0.831 |
MEK5 |
0.745 | -0.142 | 2 | 0.830 |
GRK4 |
0.745 | -0.204 | -2 | 0.770 |
ALK2 |
0.745 | -0.100 | -2 | 0.765 |
ZAK |
0.744 | -0.136 | 1 | 0.163 |
GAK |
0.744 | -0.003 | 1 | 0.305 |
PLK1 |
0.744 | -0.177 | -2 | 0.760 |
DRAK1 |
0.744 | -0.139 | 1 | 0.175 |
SNRK |
0.744 | -0.140 | 2 | 0.715 |
MLK4 |
0.743 | -0.133 | 2 | 0.723 |
MSK1 |
0.743 | -0.043 | -3 | 0.724 |
GSK3A |
0.743 | 0.118 | 4 | 0.358 |
MEKK2 |
0.743 | -0.113 | 2 | 0.811 |
CK1E |
0.743 | -0.017 | -3 | 0.591 |
CAMK1D |
0.743 | 0.023 | -3 | 0.634 |
PAK2 |
0.742 | -0.116 | -2 | 0.692 |
MARK2 |
0.742 | -0.063 | 4 | 0.676 |
BMPR1A |
0.742 | -0.077 | 1 | 0.215 |
PKCE |
0.742 | 0.020 | 2 | 0.717 |
MARK3 |
0.741 | -0.055 | 4 | 0.724 |
SSTK |
0.741 | -0.039 | 4 | 0.771 |
MEKK1 |
0.741 | -0.185 | 1 | 0.198 |
MEKK3 |
0.741 | -0.162 | 1 | 0.191 |
PRKX |
0.740 | 0.002 | -3 | 0.625 |
CAMK1A |
0.740 | 0.060 | -3 | 0.619 |
BRSK1 |
0.740 | -0.084 | -3 | 0.736 |
P70S6K |
0.740 | -0.037 | -3 | 0.682 |
TAO3 |
0.739 | -0.072 | 1 | 0.216 |
TAO2 |
0.739 | -0.046 | 2 | 0.850 |
TLK2 |
0.739 | -0.186 | 1 | 0.168 |
BIKE |
0.738 | 0.047 | 1 | 0.300 |
IRAK1 |
0.738 | -0.150 | -1 | 0.763 |
NEK5 |
0.738 | -0.156 | 1 | 0.198 |
AAK1 |
0.738 | 0.079 | 1 | 0.302 |
GRK2 |
0.738 | -0.110 | -2 | 0.655 |
MARK1 |
0.737 | -0.080 | 4 | 0.748 |
BRAF |
0.736 | -0.167 | -4 | 0.783 |
TLK1 |
0.736 | -0.154 | -2 | 0.788 |
NEK11 |
0.736 | -0.125 | 1 | 0.197 |
AURA |
0.736 | -0.073 | -2 | 0.558 |
PKACA |
0.736 | -0.020 | -2 | 0.585 |
PDK1 |
0.735 | -0.072 | 1 | 0.230 |
MEKK6 |
0.735 | -0.081 | 1 | 0.193 |
MAP3K15 |
0.735 | -0.086 | 1 | 0.176 |
CK1D |
0.735 | 0.001 | -3 | 0.543 |
PBK |
0.734 | -0.019 | 1 | 0.295 |
HGK |
0.734 | -0.047 | 3 | 0.898 |
AKT3 |
0.734 | 0.013 | -3 | 0.610 |
PASK |
0.733 | -0.069 | -3 | 0.814 |
GSK3B |
0.732 | -0.005 | 4 | 0.348 |
PLK3 |
0.732 | -0.167 | 2 | 0.741 |
MINK |
0.732 | -0.086 | 1 | 0.163 |
NEK8 |
0.732 | -0.160 | 2 | 0.826 |
PAK5 |
0.732 | -0.074 | -2 | 0.561 |
DAPK3 |
0.732 | -0.047 | -3 | 0.754 |
NEK4 |
0.731 | -0.136 | 1 | 0.167 |
LRRK2 |
0.731 | -0.024 | 2 | 0.848 |
HASPIN |
0.731 | 0.020 | -1 | 0.710 |
SGK1 |
0.731 | 0.026 | -3 | 0.597 |
LKB1 |
0.731 | -0.097 | -3 | 0.754 |
TNIK |
0.730 | -0.044 | 3 | 0.884 |
GCK |
0.730 | -0.093 | 1 | 0.191 |
MRCKB |
0.730 | -0.007 | -3 | 0.695 |
CK2A2 |
0.730 | -0.045 | 1 | 0.278 |
EEF2K |
0.729 | -0.051 | 3 | 0.865 |
TTBK1 |
0.729 | -0.155 | 2 | 0.611 |
CK1A2 |
0.729 | -0.022 | -3 | 0.543 |
MST2 |
0.729 | -0.134 | 1 | 0.185 |
MRCKA |
0.728 | -0.017 | -3 | 0.704 |
HPK1 |
0.728 | -0.074 | 1 | 0.184 |
CK1G1 |
0.728 | -0.069 | -3 | 0.588 |
KHS2 |
0.727 | -0.012 | 1 | 0.188 |
LOK |
0.727 | -0.077 | -2 | 0.724 |
KHS1 |
0.727 | -0.049 | 1 | 0.178 |
DMPK1 |
0.727 | 0.026 | -3 | 0.717 |
CAMKK1 |
0.727 | -0.198 | -2 | 0.733 |
NEK1 |
0.725 | -0.121 | 1 | 0.173 |
NEK3 |
0.724 | -0.090 | 1 | 0.184 |
RIPK2 |
0.724 | -0.159 | 1 | 0.148 |
PAK4 |
0.724 | -0.077 | -2 | 0.564 |
DAPK1 |
0.724 | -0.052 | -3 | 0.749 |
YSK1 |
0.724 | -0.087 | 2 | 0.814 |
CAMKK2 |
0.723 | -0.174 | -2 | 0.721 |
MST1 |
0.723 | -0.124 | 1 | 0.168 |
ROCK2 |
0.722 | -0.034 | -3 | 0.732 |
CK2A1 |
0.721 | -0.054 | 1 | 0.266 |
VRK1 |
0.721 | -0.173 | 2 | 0.861 |
GRK3 |
0.719 | -0.116 | -2 | 0.610 |
CRIK |
0.719 | 0.009 | -3 | 0.676 |
TAK1 |
0.719 | -0.193 | 1 | 0.176 |
PKG1 |
0.718 | -0.039 | -2 | 0.560 |
MEK2 |
0.718 | -0.193 | 2 | 0.821 |
SLK |
0.717 | -0.087 | -2 | 0.661 |
TTK |
0.716 | -0.071 | -2 | 0.771 |
PDHK3_TYR |
0.715 | 0.061 | 4 | 0.840 |
ROCK1 |
0.713 | -0.032 | -3 | 0.703 |
STK33 |
0.712 | -0.143 | 2 | 0.607 |
TESK1_TYR |
0.712 | 0.017 | 3 | 0.897 |
MYO3B |
0.712 | -0.055 | 2 | 0.827 |
TAO1 |
0.712 | -0.070 | 1 | 0.163 |
PKMYT1_TYR |
0.712 | 0.082 | 3 | 0.882 |
LIMK2_TYR |
0.711 | 0.080 | -3 | 0.828 |
OSR1 |
0.708 | -0.112 | 2 | 0.810 |
ASK1 |
0.707 | -0.132 | 1 | 0.176 |
MYO3A |
0.707 | -0.076 | 1 | 0.178 |
PDHK4_TYR |
0.707 | -0.012 | 2 | 0.872 |
PINK1_TYR |
0.704 | -0.111 | 1 | 0.274 |
MAP2K4_TYR |
0.704 | -0.078 | -1 | 0.840 |
MAP2K7_TYR |
0.703 | -0.128 | 2 | 0.858 |
LIMK1_TYR |
0.703 | -0.008 | 2 | 0.863 |
MAP2K6_TYR |
0.703 | -0.061 | -1 | 0.844 |
PLK2 |
0.702 | -0.121 | -3 | 0.773 |
BMPR2_TYR |
0.700 | -0.031 | -1 | 0.830 |
MST1R |
0.700 | -0.074 | 3 | 0.859 |
TYRO3 |
0.698 | -0.119 | 3 | 0.857 |
PDHK1_TYR |
0.698 | -0.109 | -1 | 0.840 |
ALPHAK3 |
0.698 | -0.122 | -1 | 0.723 |
TYK2 |
0.698 | -0.147 | 1 | 0.197 |
ROS1 |
0.696 | -0.114 | 3 | 0.830 |
TNNI3K_TYR |
0.696 | -0.013 | 1 | 0.237 |
RET |
0.696 | -0.148 | 1 | 0.209 |
JAK2 |
0.695 | -0.114 | 1 | 0.213 |
CSF1R |
0.694 | -0.107 | 3 | 0.850 |
TNK1 |
0.693 | -0.052 | 3 | 0.833 |
EPHA6 |
0.693 | -0.114 | -1 | 0.804 |
LCK |
0.693 | -0.059 | -1 | 0.764 |
YES1 |
0.692 | -0.101 | -1 | 0.779 |
NEK10_TYR |
0.692 | -0.099 | 1 | 0.173 |
HCK |
0.691 | -0.094 | -1 | 0.768 |
STLK3 |
0.691 | -0.183 | 1 | 0.144 |
YANK3 |
0.691 | -0.074 | 2 | 0.375 |
TEK |
0.691 | -0.012 | 3 | 0.802 |
JAK3 |
0.691 | -0.125 | 1 | 0.204 |
TXK |
0.690 | -0.097 | 1 | 0.248 |
EPHB4 |
0.690 | -0.143 | -1 | 0.790 |
DDR1 |
0.690 | -0.153 | 4 | 0.794 |
TNK2 |
0.689 | -0.115 | 3 | 0.807 |
ABL2 |
0.689 | -0.125 | -1 | 0.746 |
BLK |
0.688 | -0.071 | -1 | 0.764 |
WEE1_TYR |
0.688 | -0.030 | -1 | 0.741 |
JAK1 |
0.688 | -0.086 | 1 | 0.169 |
FLT3 |
0.687 | -0.125 | 3 | 0.859 |
FGFR1 |
0.687 | -0.060 | 3 | 0.823 |
FGR |
0.687 | -0.165 | 1 | 0.235 |
FGFR2 |
0.686 | -0.084 | 3 | 0.834 |
ABL1 |
0.686 | -0.123 | -1 | 0.737 |
ITK |
0.685 | -0.132 | -1 | 0.762 |
FER |
0.685 | -0.184 | 1 | 0.249 |
CK1A |
0.685 | -0.065 | -3 | 0.461 |
INSRR |
0.685 | -0.148 | 3 | 0.808 |
PDGFRB |
0.685 | -0.175 | 3 | 0.857 |
AXL |
0.684 | -0.146 | 3 | 0.832 |
KDR |
0.683 | -0.103 | 3 | 0.811 |
KIT |
0.682 | -0.140 | 3 | 0.851 |
EPHA4 |
0.681 | -0.112 | 2 | 0.743 |
PDGFRA |
0.681 | -0.160 | 3 | 0.854 |
EPHB1 |
0.681 | -0.160 | 1 | 0.204 |
EPHB3 |
0.681 | -0.157 | -1 | 0.775 |
MERTK |
0.680 | -0.144 | 3 | 0.825 |
TEC |
0.680 | -0.122 | -1 | 0.705 |
EPHB2 |
0.679 | -0.152 | -1 | 0.759 |
FYN |
0.679 | -0.077 | -1 | 0.740 |
SRMS |
0.679 | -0.193 | 1 | 0.214 |
BMX |
0.678 | -0.109 | -1 | 0.676 |
BTK |
0.678 | -0.165 | -1 | 0.739 |
LYN |
0.677 | -0.099 | 3 | 0.791 |
FRK |
0.676 | -0.118 | -1 | 0.774 |
MET |
0.676 | -0.144 | 3 | 0.833 |
EPHA1 |
0.676 | -0.134 | 3 | 0.821 |
ALK |
0.675 | -0.153 | 3 | 0.781 |
ERBB2 |
0.674 | -0.147 | 1 | 0.182 |
NTRK2 |
0.673 | -0.186 | 3 | 0.825 |
DDR2 |
0.672 | -0.081 | 3 | 0.788 |
INSR |
0.672 | -0.154 | 3 | 0.792 |
LTK |
0.672 | -0.160 | 3 | 0.792 |
FGFR3 |
0.672 | -0.110 | 3 | 0.812 |
PTK2B |
0.671 | -0.115 | -1 | 0.727 |
EPHA3 |
0.671 | -0.137 | 2 | 0.726 |
FLT4 |
0.671 | -0.151 | 3 | 0.805 |
MUSK |
0.671 | -0.095 | 1 | 0.140 |
EPHA7 |
0.670 | -0.145 | 2 | 0.755 |
NTRK1 |
0.668 | -0.224 | -1 | 0.771 |
SRC |
0.668 | -0.118 | -1 | 0.727 |
PTK6 |
0.666 | -0.213 | -1 | 0.683 |
FLT1 |
0.665 | -0.178 | -1 | 0.763 |
CK1G3 |
0.664 | -0.071 | -3 | 0.414 |
NTRK3 |
0.664 | -0.174 | -1 | 0.718 |
EGFR |
0.664 | -0.124 | 1 | 0.146 |
EPHA5 |
0.664 | -0.152 | 2 | 0.735 |
EPHA8 |
0.663 | -0.136 | -1 | 0.746 |
MATK |
0.662 | -0.135 | -1 | 0.665 |
PTK2 |
0.659 | -0.078 | -1 | 0.733 |
YANK2 |
0.659 | -0.092 | 2 | 0.387 |
CSK |
0.656 | -0.175 | 2 | 0.756 |
ERBB4 |
0.656 | -0.102 | 1 | 0.162 |
SYK |
0.654 | -0.108 | -1 | 0.699 |
IGF1R |
0.654 | -0.156 | 3 | 0.737 |
FGFR4 |
0.652 | -0.152 | -1 | 0.688 |
EPHA2 |
0.650 | -0.150 | -1 | 0.709 |
FES |
0.645 | -0.138 | -1 | 0.647 |
CK1G2 |
0.640 | -0.084 | -3 | 0.503 |
ZAP70 |
0.639 | -0.096 | -1 | 0.645 |