Motif 83 (n=200)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| B2RTY4 | MYO9A | S1733 | ochoa | Unconventional myosin-IXa (Unconventional myosin-9a) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating it's GTPase activity in neurons. Required for the regulation of neurite branching and motor neuron axon guidance (By similarity). {ECO:0000250|UniProtKB:Q8C170, ECO:0000250|UniProtKB:Q9Z1N3}. |
| O00124 | UBXN8 | S167 | ochoa | UBX domain-containing protein 8 (Reproduction 8 protein) (Rep-8 protein) (UBX domain-containing protein 6) | Involved in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins, possibly by tethering VCP to the endoplasmic reticulum membrane. May play a role in reproduction. {ECO:0000269|PubMed:21949850}. |
| O00305 | CACNB4 | S51 | ochoa | Voltage-dependent L-type calcium channel subunit beta-4 (CAB4) (Calcium channel voltage-dependent subunit beta 4) | The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. {ECO:0000269|PubMed:11880487}. |
| O00423 | EML1 | S140 | ochoa | Echinoderm microtubule-associated protein-like 1 (EMAP-1) (HuEMAP-1) | Modulates the assembly and organization of the microtubule cytoskeleton, and probably plays a role in regulating the orientation of the mitotic spindle and the orientation of the plane of cell division. Required for normal proliferation of neuronal progenitor cells in the developing brain and for normal brain development. Does not affect neuron migration per se. {ECO:0000250|UniProtKB:Q05BC3}. |
| O14649 | KCNK3 | S358 | psp | Potassium channel subfamily K member 3 (Acid-sensitive potassium channel protein TASK-1) (TWIK-related acid-sensitive K(+) channel 1) (Two pore potassium channel KT3.1) (Two pore K(+) channel KT3.1) | K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate (PubMed:23169818, PubMed:26919430, PubMed:32499642, PubMed:36195757, PubMed:9312005). Changes ion selectivity and becomes permeable to Na(+) ions in response to extracellular acidification. Protonation of the pH sensor His-98 stabilizes C-type inactivation conformation likely converting the channel from outward K(+)-conducting, to inward Na(+)-conducting to nonconductive state (PubMed:22948150). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (PubMed:23169818, PubMed:32499642). Allows K(+) currents with fast-gating kinetics important for the repolarization and hyperpolarization phases of action potentials (By similarity). In cerebellar granule cells, heteromeric KCNK3:KCNK9 channel may hyperpolarize the resting membrane potential to limit intrinsic neuronal excitability, but once the action potential threshold is reached, it may support high-frequency action potential firing and increased neuronal excitability (By similarity). Dispensable for central chemosensory respiration i.e. breathing controlled by brainstem CO2/pH, it rather conducts pH-sensitive currents and controls the firing rate of serotonergic raphe neurons involved in potentiation of the respiratory chemoreflex. Additionally, imparts chemosensitivity to type 1 cells in carotid bodies which respond to a decrease in arterial oxygen pressure or an increase in carbon dioxide pressure or pH to initiate adaptive changes in pulmonary ventilation (By similarity). In adrenal gland, contributes to the maintenance of a hyperpolarized resting membrane potential of aldosterone-producing cells at zona glomerulosa and limits aldosterone release as part of a regulatory mechanism that controls arterial blood pressure and electrolyte homeostasis (By similarity). In brown adipocytes, mediates K(+) efflux that counteracts norepinephrine-induced membrane depolarization, limits Ca(2+) efflux and downstream cAMP and PKA signaling, ultimately attenuating lipid oxidation and adaptive thermogenesis (By similarity). {ECO:0000250|UniProtKB:O35111, ECO:0000250|UniProtKB:O54912, ECO:0000269|PubMed:22948150, ECO:0000269|PubMed:23169818, ECO:0000269|PubMed:26919430, ECO:0000269|PubMed:32499642, ECO:0000269|PubMed:36195757, ECO:0000269|PubMed:9312005}. |
| O14791 | APOL1 | S314 | ochoa | Apolipoprotein L1 (Apolipoprotein L) (Apo-L) (ApoL) (Apolipoprotein L-I) (ApoL-I) | May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver. |
| O14920 | IKBKB | S258 | psp | Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK-2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) (Serine/threonine protein kinase IKBKB) (EC 2.7.11.1) | Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:30337470, PubMed:9346484). Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation (PubMed:9346484). Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE (PubMed:11297557, PubMed:14673179, PubMed:20410276, PubMed:21138416). IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs (PubMed:11297557, PubMed:20410276, PubMed:21138416). Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor (PubMed:15084260). Also phosphorylates other substrates including NAA10, NCOA3, BCL10 and IRS1 (PubMed:17213322, PubMed:19716809). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates the C-terminus of IRF5, stimulating IRF5 homodimerization and translocation into the nucleus (PubMed:25326418). Following bacterial lipopolysaccharide (LPS)-induced TLR4 endocytosis, phosphorylates STAT1 at 'Thr-749' which restricts interferon signaling and anti-inflammatory responses and promotes innate inflammatory responses (PubMed:38621137). IKBKB-mediated phosphorylation of STAT1 at 'Thr-749' promotes binding of STAT1 to the ARID5A promoter, resulting in transcriptional activation of ARID5A and subsequent ARID5A-mediated stabilization of IL6 (PubMed:32209697). It also promotes binding of STAT1 to the IL12B promoter and activation of IL12B transcription (PubMed:32209697). {ECO:0000250|UniProtKB:O88351, ECO:0000269|PubMed:11297557, ECO:0000269|PubMed:14673179, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17213322, ECO:0000269|PubMed:19716809, ECO:0000269|PubMed:20410276, ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20797629, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:25326418, ECO:0000269|PubMed:30337470, ECO:0000269|PubMed:32209697, ECO:0000269|PubMed:38621137, ECO:0000269|PubMed:9346484}. |
| O14948 | TFEC | S326 | ochoa | Transcription factor EC (TFE-C) (Class E basic helix-loop-helix protein 34) (bHLHe34) (Transcription factor EC-like) (hTFEC-L) | Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence). Binds to element F in an E-box sequence-specific manner. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter (By similarity). Collaborates with MITF in target gene activation (By similarity). Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (By similarity). Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer (By similarity). Binds DNA in a homo- or heterodimeric form. {ECO:0000250, ECO:0000269|PubMed:11467950, ECO:0000269|PubMed:9256061}. |
| O15015 | ZNF646 | S991 | ochoa | Zinc finger protein 646 | May be involved in transcriptional regulation. |
| O15061 | SYNM | S379 | ochoa | Synemin (Desmuslin) | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}. |
| O15151 | MDM4 | S403 | psp | Protein Mdm4 (Double minute 4 protein) (Mdm2-like p53-binding protein) (Protein Mdmx) (p53-binding protein Mdm4) | Along with MDM2, contributes to TP53 regulation (PubMed:32300648). Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions. {ECO:0000269|PubMed:16163388, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:32300648}. |
| O15381 | NVL | S134 | ochoa | Nuclear valosin-containing protein-like (NVLp) (Nuclear VCP-like protein) | Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT (PubMed:22226966). Involved in both early and late stages of the pre-rRNA processing pathways (PubMed:26166824). Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus (PubMed:15469983, PubMed:16782053, PubMed:26456651, PubMed:29107693). Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity (PubMed:26456651, PubMed:28416111, PubMed:29107693). {ECO:0000269|PubMed:15469983, ECO:0000269|PubMed:16782053, ECO:0000269|PubMed:22226966, ECO:0000269|PubMed:26166824, ECO:0000269|PubMed:26456651, ECO:0000269|PubMed:28416111, ECO:0000269|PubMed:29107693}. |
| O15530 | PDPK1 | S393 | psp | 3-phosphoinositide-dependent protein kinase 1 (hPDK1) (EC 2.7.11.1) | Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases (PubMed:10226025, PubMed:10480933, PubMed:10995762, PubMed:12167717, PubMed:14585963, PubMed:14604990, PubMed:16207722, PubMed:16251192, PubMed:17327236, PubMed:17371830, PubMed:18835241, PubMed:9094314, PubMed:9368760, PubMed:9445476, PubMed:9445477, PubMed:9707564, PubMed:9768361). Its targets include: protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), p70 ribosomal protein S6 kinase (RPS6KB1), p90 ribosomal protein S6 kinase (RPS6KA1, RPS6KA2 and RPS6KA3), cyclic AMP-dependent protein kinase (PRKACA), protein kinase C (PRKCD and PRKCZ), serum and glucocorticoid-inducible kinase (SGK1, SGK2 and SGK3), p21-activated kinase-1 (PAK1), TSSK3, protein kinase PKN (PKN1 and PKN2) (PubMed:10226025, PubMed:10480933, PubMed:10995762, PubMed:12167717, PubMed:14585963, PubMed:14604990, PubMed:16207722, PubMed:16251192, PubMed:17327236, PubMed:17371830, PubMed:18835241, PubMed:9094314, PubMed:9368760, PubMed:9445476, PubMed:9707564, PubMed:9768361). Plays a central role in the transduction of signals from insulin by providing the activating phosphorylation to PKB/AKT1, thus propagating the signal to downstream targets controlling cell proliferation and survival, as well as glucose and amino acid uptake and storage (PubMed:10226025, PubMed:12167717, PubMed:9094314). Negatively regulates the TGF-beta-induced signaling by: modulating the association of SMAD3 and SMAD7 with TGF-beta receptor, phosphorylating SMAD2, SMAD3, SMAD4 and SMAD7, preventing the nuclear translocation of SMAD3 and SMAD4 and the translocation of SMAD7 from the nucleus to the cytoplasm in response to TGF-beta (PubMed:17327236). Activates PPARG transcriptional activity and promotes adipocyte differentiation (By similarity). Activates the NF-kappa-B pathway via phosphorylation of IKKB (PubMed:16207722). The tyrosine phosphorylated form is crucial for the regulation of focal adhesions by angiotensin II (PubMed:14585963). Controls proliferation, survival, and growth of developing pancreatic cells (By similarity). Participates in the regulation of Ca(2+) entry and Ca(2+)-activated K(+) channels of mast cells (By similarity). Essential for the motility of vascular endothelial cells (ECs) and is involved in the regulation of their chemotaxis (PubMed:17371830). Plays a critical role in cardiac homeostasis by serving as a dual effector for cell survival and beta-adrenergic response (By similarity). Plays an important role during thymocyte development by regulating the expression of key nutrient receptors on the surface of pre-T cells and mediating Notch-induced cell growth and proliferative responses (By similarity). Provides negative feedback inhibition to toll-like receptor-mediated NF-kappa-B activation in macrophages (By similarity). {ECO:0000250|UniProtKB:Q9Z2A0, ECO:0000269|PubMed:10226025, ECO:0000269|PubMed:10480933, ECO:0000269|PubMed:10995762, ECO:0000269|PubMed:12167717, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:14604990, ECO:0000269|PubMed:16207722, ECO:0000269|PubMed:16251192, ECO:0000269|PubMed:17327236, ECO:0000269|PubMed:17371830, ECO:0000269|PubMed:18835241, ECO:0000269|PubMed:9094314, ECO:0000269|PubMed:9368760, ECO:0000269|PubMed:9445476, ECO:0000269|PubMed:9445477, ECO:0000269|PubMed:9707564, ECO:0000269|PubMed:9768361}.; FUNCTION: [Isoform 3]: Catalytically inactive. {ECO:0000269|PubMed:9445477}. |
| O43314 | PPIP5K2 | S1139 | ochoa | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 2) (Histidine acid phosphatase domain-containing protein 1) (InsP6 and PP-IP5 kinase 2) (VIP1 homolog 2) (hsVIP2) | Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4 (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Required for normal hearing (PubMed:29590114). {ECO:0000269|PubMed:17690096, ECO:0000269|PubMed:17702752, ECO:0000269|PubMed:21222653, ECO:0000269|PubMed:29590114}. |
| O43361 | ZNF749 | S722 | ochoa | Zinc finger protein 749 | May be involved in transcriptional regulation. |
| O75037 | KIF21B | S1149 | ochoa | Kinesin-like protein KIF21B | Plus-end directed microtubule-dependent motor protein which displays processive activity. Is involved in regulation of microtubule dynamics, synapse function and neuronal morphology, including dendritic tree branching and spine formation. Plays a role in lerning and memory. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptor to cell surface. {ECO:0000250|UniProtKB:Q9QXL1}. |
| O75417 | POLQ | S1651 | ochoa | DNA polymerase theta (DNA polymerase eta) [Includes: Helicase POLQ (EC 3.6.4.12); DNA polymerase POLQ (EC 2.7.7.7) (RNA-directed DNA polymerase POLQ) (EC 2.7.7.49)] | Low-fidelity DNA polymerase with a helicase activity that promotes microhomology-mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery required to repair double-strand breaks in DNA during mitosis (PubMed:14576298, PubMed:18503084, PubMed:24648516, PubMed:25642963, PubMed:25643323, PubMed:25775267, PubMed:26636256, PubMed:27311885, PubMed:27591252, PubMed:30655289, PubMed:31562312, PubMed:32873648, PubMed:34140467, PubMed:34179826, PubMed:36455556, PubMed:37440612, PubMed:37674080). MMEJ is an error-prone repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements, such as telomere fusions, some of them leading to cellular transformation (PubMed:25642963, PubMed:25643323, PubMed:25775267, PubMed:27311885, PubMed:27591252, PubMed:31562312, PubMed:32873648). MMEJ is required during mitosis to repair persistent double-strand breaks that originate in S-phase (PubMed:37440612, PubMed:37674080). Although error-prone, MMEJ protects against chromosomal instability and tumorigenesis (By similarity). The polymerase acts by binding directly the 2 ends of resected double-strand breaks, allowing microhomologous sequences in the overhangs to form base pairs (PubMed:25643323, PubMed:25775267, PubMed:27311885, PubMed:27591252). It then extends each strand from the base-paired region using the opposing overhang as a template (PubMed:25643323, PubMed:25775267, PubMed:27311885, PubMed:27591252). Requires partially resected DNA containing 2 to 6 base pairs of microhomology to perform MMEJ (PubMed:25643323, PubMed:25775267, PubMed:27311885, PubMed:27591252). The polymerase lacks proofreading activity and is highly promiscuous: unlike most polymerases, promotes extension of ssDNA and partial ssDNA (pssDNA) substrates (PubMed:18503084, PubMed:21050863, PubMed:22135286). When the ends of a break do not contain terminal microhomology must identify embedded complementary sequences through a scanning step (PubMed:32234782). Also acts as a DNA helicase, promoting dissociation of the replication protein A complex (RPA/RP-A), composed of RPA1, RPA2 and RPA3, from resected double-strand breaks to allow their annealing and subsequent joining by MMEJ (PubMed:36455556). Removal of RPA/RP-A complex proteins prevents RAD51 accumulation at resected ends, thereby inhibiting homology-recombination repair (HR) pathway (PubMed:25642963, PubMed:28695890). Also shows RNA-directed DNA polymerase activity to mediate DNA repair in vitro; however this activity needs additional evidence in vivo (PubMed:34117057). May also have lyase activity (PubMed:19188258). Involved in somatic hypermutation of immunoglobulin genes, a process that requires the activity of DNA polymerases to ultimately introduce mutations at both A/T and C/G base pairs (By similarity). POLQ-mediated end joining activity is involved in random integration of exogenous DNA hampers (PubMed:28695890). {ECO:0000250|UniProtKB:Q8CGS6, ECO:0000269|PubMed:14576298, ECO:0000269|PubMed:18503084, ECO:0000269|PubMed:19188258, ECO:0000269|PubMed:21050863, ECO:0000269|PubMed:22135286, ECO:0000269|PubMed:24648516, ECO:0000269|PubMed:25642963, ECO:0000269|PubMed:25643323, ECO:0000269|PubMed:25775267, ECO:0000269|PubMed:26636256, ECO:0000269|PubMed:27311885, ECO:0000269|PubMed:27591252, ECO:0000269|PubMed:28695890, ECO:0000269|PubMed:30655289, ECO:0000269|PubMed:31562312, ECO:0000269|PubMed:32234782, ECO:0000269|PubMed:32873648, ECO:0000269|PubMed:34117057, ECO:0000269|PubMed:34140467, ECO:0000269|PubMed:34179826, ECO:0000269|PubMed:36455556, ECO:0000269|PubMed:37440612, ECO:0000269|PubMed:37674080}. |
| O75460 | ERN1 | S548 | ochoa | Serine/threonine-protein kinase/endoribonuclease IRE1 (Endoplasmic reticulum-to-nucleus signaling 1) (Inositol-requiring protein 1) (hIRE1p) (Ire1-alpha) (IRE1a) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)] | Serine/threonine-protein kinase and endoribonuclease that acts as a key sensor for the endoplasmic reticulum unfolded protein response (UPR) (PubMed:11175748, PubMed:11779464, PubMed:12637535, PubMed:19328063, PubMed:21317875, PubMed:28128204, PubMed:30118681, PubMed:36739529, PubMed:9637683). In unstressed cells, the endoplasmic reticulum luminal domain is maintained in its inactive monomeric state by binding to the endoplasmic reticulum chaperone HSPA5/BiP (PubMed:21317875). Accumulation of misfolded proteins in the endoplasmic reticulum causes release of HSPA5/BiP, allowing the luminal domain to homodimerize, promoting autophosphorylation of the kinase domain and subsequent activation of the endoribonuclease activity (PubMed:21317875). The endoribonuclease activity is specific for XBP1 mRNA and excises 26 nucleotides from XBP1 mRNA (PubMed:11779464, PubMed:21317875, PubMed:24508390). The resulting spliced transcript of XBP1 encodes a transcriptional activator protein that up-regulates expression of UPR target genes (PubMed:11779464, PubMed:21317875, PubMed:24508390). Acts as an upstream signal for ER stress-induced GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane by modulating the expression and localization of SEC16A (PubMed:21884936, PubMed:28067262). {ECO:0000269|PubMed:11175748, ECO:0000269|PubMed:11779464, ECO:0000269|PubMed:12637535, ECO:0000269|PubMed:19328063, ECO:0000269|PubMed:21317875, ECO:0000269|PubMed:21884936, ECO:0000269|PubMed:28067262, ECO:0000269|PubMed:28128204, ECO:0000269|PubMed:30118681, ECO:0000269|PubMed:36739529, ECO:0000269|PubMed:9637683, ECO:0000305|PubMed:24508390}. |
| O94885 | SASH1 | S244 | ochoa | SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) | Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). {ECO:0000269|PubMed:23333244, ECO:0000269|PubMed:23776175, ECO:0000269|PubMed:25315659}. |
| O94916 | NFAT5 | S1367 | psp | Nuclear factor of activated T-cells 5 (NF-AT5) (T-cell transcription factor NFAT5) (Tonicity-responsive enhancer-binding protein) (TonE-binding protein) (TonEBP) | Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3' (PubMed:10377394). Mediates the transcriptional response to hypertonicity (PubMed:10051678). Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17 (PubMed:22266867). Also involved in the DNA damage response by preventing formation of R-loops; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:34049076). {ECO:0000269|PubMed:10051678, ECO:0000269|PubMed:10377394, ECO:0000269|PubMed:22266867, ECO:0000269|PubMed:34049076}. |
| O95625 | ZBTB11 | S454 | ochoa | Zinc finger and BTB domain-containing protein 11 | May be involved in transcriptional regulation. {ECO:0000305}. |
| P04114 | APOB | S1775 | ochoa | Apolipoprotein B-100 (Apo B-100) [Cleaved into: Apolipoprotein B-48 (Apo B-48)] | Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. |
| P05121 | SERPINE1 | S218 | ochoa | Plasminogen activator inhibitor 1 (PAI) (PAI-1) (Endothelial plasminogen activator inhibitor) (Serpin E1) | Serine protease inhibitor. Inhibits TMPRSS7 (PubMed:15853774). Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots (PubMed:17912461, PubMed:8481516, PubMed:9207454, PubMed:21925150). As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading (PubMed:9175705). Acts as a regulator of cell migration, independently of its role as protease inhibitor (PubMed:15001579, PubMed:9168821). It is required for stimulation of keratinocyte migration during cutaneous injury repair (PubMed:18386027). It is involved in cellular and replicative senescence (PubMed:16862142). Plays a role in alveolar type 2 cells senescence in the lung (By similarity). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (PubMed:25808697, PubMed:27046084). {ECO:0000250|UniProtKB:P22777, ECO:0000269|PubMed:15001579, ECO:0000269|PubMed:15853774, ECO:0000269|PubMed:16862142, ECO:0000269|PubMed:17912461, ECO:0000269|PubMed:18386027, ECO:0000269|PubMed:21925150, ECO:0000269|PubMed:25808697, ECO:0000269|PubMed:27046084, ECO:0000269|PubMed:8481516, ECO:0000269|PubMed:9168821, ECO:0000269|PubMed:9175705, ECO:0000269|PubMed:9207454}. |
| P09525 | ANXA4 | S154 | ochoa | Annexin A4 (35-beta calcimedin) (Annexin IV) (Annexin-4) (Carbohydrate-binding protein p33/p41) (Chromobindin-4) (Endonexin I) (Lipocortin IV) (P32.5) (PP4-X) (Placental anticoagulant protein II) (PAP-II) (Protein II) | Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. {ECO:0000250}. |
| P10645 | CHGA | S53 | ochoa | Chromogranin-A (CgA) (Pituitary secretory protein I) (SP-I) [Cleaved into: Vasostatin-1 (Vasostatin I); Vasostatin-2 (Vasostatin II); EA-92; ES-43; Pancreastatin; SS-18; WA-8; WE-14; LF-19; Catestatin (SL21); AL-11; GV-19; GR-44; ER-37; GE-25; Serpinin-RRG; Serpinin; p-Glu serpinin precursor] | [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas.; FUNCTION: [Catestatin]: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist (PubMed:15326220). Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa (PubMed:15723172, PubMed:24723458). Can induce mast cell migration, degranulation and production of cytokines and chemokines (PubMed:21214543). Acts as a potent scavenger of free radicals in vitro (PubMed:24723458). May play a role in the regulation of cardiac function and blood pressure (PubMed:18541522). {ECO:0000269|PubMed:15326220, ECO:0000269|PubMed:15723172, ECO:0000269|PubMed:21214543, ECO:0000269|PubMed:24723458, ECO:0000303|PubMed:18541522}.; FUNCTION: [Serpinin]: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation. {ECO:0000250|UniProtKB:P26339}. |
| P11274 | BCR | S638 | ochoa | Breakpoint cluster region protein (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-26) | Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed:17116687, PubMed:1903516, PubMed:7479768). The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed:23940119, PubMed:7479768). The amino terminus contains an intrinsic kinase activity (PubMed:1657398). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity (PubMed:17116687). Plays a major role as a RHOA GEF in keratinocytes being involved in focal adhesion formation and keratinocyte differentiation (PubMed:23940119). {ECO:0000250|UniProtKB:Q6PAJ1, ECO:0000269|PubMed:1657398, ECO:0000269|PubMed:17116687, ECO:0000269|PubMed:1903516, ECO:0000269|PubMed:23940119, ECO:0000269|PubMed:7479768}. |
| P15036 | ETS2 | S310 | ochoa|psp | Protein C-ets-2 | Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription. {ECO:0000269|PubMed:11909962}. |
| P15822 | HIVEP1 | S2033 | ochoa | Zinc finger protein 40 (Cirhin interaction protein) (CIRIP) (Gate keeper of apoptosis-activating protein) (GAAP) (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis. |
| P20393 | NR1D1 | S55 | psp | Nuclear receptor subfamily 1 group D member 1 (Rev-erbA-alpha) (V-erbA-related protein 1) (EAR-1) | Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components BMAL1, CLOCK and CRY1. Also regulates genes involved in metabolic functions, including lipid and bile acid metabolism, adipogenesis, gluconeogenesis and the macrophage inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced by two nucleotides (RevDR-2). Acts as a potent competitive repressor of ROR alpha (RORA) function and regulates the levels of its ligand heme by repressing the expression of PPARGC1A, a potent inducer of heme synthesis. Regulates lipid metabolism by repressing the expression of APOC3 and by influencing the activity of sterol response element binding proteins (SREBPs); represses INSIG2 which interferes with the proteolytic activation of SREBPs which in turn govern the rhythmic expression of enzymes with key functions in sterol and fatty acid synthesis. Regulates gluconeogenesis via repression of G6PC1 and PEPCK and adipocyte differentiation via repression of PPARG. Regulates glucagon release in pancreatic alpha-cells via the AMPK-NAMPT-SIRT1 pathway and the proliferation, glucose-induced insulin secretion and expression of key lipogenic genes in pancreatic-beta cells. Positively regulates bile acid synthesis by increasing hepatic expression of CYP7A1 via repression of NR0B2 and NFIL3 which are negative regulators of CYP7A1. Modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy; controls mitochondrial biogenesis and respiration by interfering with the STK11-PRKAA1/2-SIRT1-PPARGC1A signaling pathway. Represses the expression of SERPINE1/PAI1, an important modulator of cardiovascular disease and the expression of inflammatory cytokines and chemokines in macrophages. Represses gene expression at a distance in macrophages by inhibiting the transcription of enhancer-derived RNAs (eRNAs). Plays a role in the circadian regulation of body temperature and negatively regulates thermogenic transcriptional programs in brown adipose tissue (BAT); imposes a circadian oscillation in BAT activity, increasing body temperature when awake and depressing thermogenesis during sleep. In concert with NR2E3, regulates transcriptional networks critical for photoreceptor development and function. In addition to its activity as a repressor, can also act as a transcriptional activator. In the ovarian granulosa cells acts as a transcriptional activator of STAR which plays a role in steroid biosynthesis. In collaboration with SP1, activates GJA1 transcription in a heme-independent manner. Represses the transcription of CYP2B10, CYP4A10 and CYP4A14 (By similarity). Represses the transcription of CES2 (By similarity). Represses and regulates the circadian expression of TSHB in a NCOR1-dependent manner (By similarity). Negatively regulates the protein stability of NR3C1 and influences the time-dependent subcellular distribution of NR3C1, thereby affecting its transcriptional regulatory activity (By similarity). Plays a critical role in the circadian control of neutrophilic inflammation in the lung; under resting, non-stress conditions, acts as a rhythmic repressor to limit inflammatory activity whereas in the presence of inflammatory triggers undergoes ubiquitin-mediated degradation thereby relieving inhibition of the inflammatory response (By similarity). Plays a key role in the circadian regulation of microglial activation and neuroinflammation; suppresses microglial activation through the NF-kappaB pathway in the central nervous system (By similarity). Plays a role in the regulation of the diurnal rhythms of lipid and protein metabolism in the skeletal muscle via transcriptional repression of genes controlling lipid and amino acid metabolism in the muscle (By similarity). {ECO:0000250|UniProtKB:Q3UV55, ECO:0000269|PubMed:12021280, ECO:0000269|PubMed:15761026, ECO:0000269|PubMed:16968709, ECO:0000269|PubMed:18006707, ECO:0000269|PubMed:19710360, ECO:0000269|PubMed:1971514, ECO:0000269|PubMed:21479263, ECO:0000269|PubMed:22184247, ECO:0000269|PubMed:23398316, ECO:0000269|PubMed:2539258}. |
| P21980 | TGM2 | S68 | psp | Protein-glutamine gamma-glutamyltransferase 2 (EC 2.3.2.13) (Erythrocyte transglutaminase) (Heart G alpha(h)) (hhG alpha(h)) (Isopeptidase TGM2) (EC 3.4.-.-) (Protein G alpha(h)) (G(h)) (Protein-glutamine deamidase TGM2) (EC 3.5.1.44) (Protein-glutamine dopaminyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine histaminyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine noradrenalinyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine serotonyltransferase TGM2) (EC 2.3.1.-) (Tissue transglutaminase) (tTG) (tTgase) (Transglutaminase C) (TG(C)) (TGC) (TGase C) (Transglutaminase H) (TGase H) (Transglutaminase II) (TGase II) (Transglutaminase-2) (TG2) (TGase-2) (hTG2) | Calcium-dependent acyltransferase that catalyzes the formation of covalent bonds between peptide-bound glutamine and various primary amines, such as gamma-amino group of peptide-bound lysine, or mono- and polyamines, thereby producing cross-linked or aminated proteins, respectively (PubMed:23941696, PubMed:31991788, PubMed:9252372). Involved in many biological processes, such as bone development, angiogenesis, wound healing, cellular differentiation, chromatin modification and apoptosis (PubMed:1683874, PubMed:27270573, PubMed:28198360, PubMed:7935379, PubMed:9252372). Acts as a protein-glutamine gamma-glutamyltransferase by mediating the cross-linking of proteins, such as ACO2, HSPB6, FN1, HMGB1, RAP1GDS1, SLC25A4/ANT1, SPP1 and WDR54 (PubMed:23941696, PubMed:24349085, PubMed:29618516, PubMed:30458214). Under physiological conditions, the protein cross-linking activity is inhibited by GTP; inhibition is relieved by Ca(2+) in response to various stresses (PubMed:18092889, PubMed:7592956, PubMed:7649299). When secreted, catalyzes cross-linking of proteins of the extracellular matrix, such as FN1 and SPP1 resulting in the formation of scaffolds (PubMed:12506096). Plays a key role during apoptosis, both by (1) promoting the cross-linking of cytoskeletal proteins resulting in condensation of the cytoplasm, and by (2) mediating cross-linking proteins of the extracellular matrix, resulting in the irreversible formation of scaffolds that stabilize the integrity of the dying cells before their clearance by phagocytosis, thereby preventing the leakage of harmful intracellular components (PubMed:7935379, PubMed:9252372). In addition to protein cross-linking, can use different monoamine substrates to catalyze a vast array of protein post-translational modifications: mediates aminylation of serotonin, dopamine, noradrenaline or histamine into glutamine residues of target proteins to generate protein serotonylation, dopaminylation, noradrenalinylation or histaminylation, respectively (PubMed:23797785, PubMed:30867594). Mediates protein serotonylation of small GTPases during activation and aggregation of platelets, leading to constitutive activation of these GTPases (By similarity). Plays a key role in chromatin organization by mediating serotonylation and dopaminylation of histone H3 (PubMed:30867594, PubMed:32273471). Catalyzes serotonylation of 'Gln-5' of histone H3 (H3Q5ser) during serotonergic neuron differentiation, thereby facilitating transcription (PubMed:30867594). Acts as a mediator of neurotransmission-independent role of nuclear dopamine in ventral tegmental area (VTA) neurons: catalyzes dopaminylation of 'Gln-5' of histone H3 (H3Q5dop), thereby regulating relapse-related transcriptional plasticity in the reward system (PubMed:32273471). Regulates vein remodeling by mediating serotonylation and subsequent inactivation of ATP2A2/SERCA2 (By similarity). Also acts as a protein deamidase by mediating the side chain deamidation of specific glutamine residues of proteins to glutamate (PubMed:20547769, PubMed:9623982). Catalyzes specific deamidation of protein gliadin, a component of wheat gluten in the diet (PubMed:9623982). May also act as an isopeptidase cleaving the previously formed cross-links (PubMed:26250429, PubMed:27131890). Also able to participate in signaling pathways independently of its acyltransferase activity: acts as a signal transducer in alpha-1 adrenergic receptor-mediated stimulation of phospholipase C-delta (PLCD) activity and is required for coupling alpha-1 adrenergic agonists to the stimulation of phosphoinositide lipid metabolism (PubMed:8943303). {ECO:0000250|UniProtKB:P08587, ECO:0000250|UniProtKB:P21981, ECO:0000269|PubMed:12506096, ECO:0000269|PubMed:1683874, ECO:0000269|PubMed:18092889, ECO:0000269|PubMed:20547769, ECO:0000269|PubMed:23797785, ECO:0000269|PubMed:23941696, ECO:0000269|PubMed:24349085, ECO:0000269|PubMed:26250429, ECO:0000269|PubMed:27131890, ECO:0000269|PubMed:28198360, ECO:0000269|PubMed:29618516, ECO:0000269|PubMed:30458214, ECO:0000269|PubMed:30867594, ECO:0000269|PubMed:31991788, ECO:0000269|PubMed:32273471, ECO:0000269|PubMed:7592956, ECO:0000269|PubMed:7649299, ECO:0000269|PubMed:7935379, ECO:0000269|PubMed:8943303, ECO:0000269|PubMed:9252372, ECO:0000269|PubMed:9623982, ECO:0000303|PubMed:27270573}.; FUNCTION: [Isoform 2]: Has cytotoxic activity: is able to induce apoptosis independently of its acyltransferase activity. {ECO:0000269|PubMed:17116873}. |
| P23327 | HRC | S75 | ochoa | Sarcoplasmic reticulum histidine-rich calcium-binding protein | May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle. |
| P26232 | CTNNA2 | S321 | ochoa | Catenin alpha-2 (Alpha N-catenin) (Alpha-catenin-related protein) | May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system (By similarity). Required for proper regulation of cortical neuronal migration and neurite growth (PubMed:30013181). It acts as a negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization (PubMed:30013181). It thereby suppresses excessive actin branching which would impair neurite growth and stability (PubMed:30013181). Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation (By similarity). {ECO:0000250|UniProtKB:Q61301, ECO:0000269|PubMed:30013181}. |
| P31260 | HOXA10 | S322 | ochoa | Homeobox protein Hox-A10 (Homeobox protein Hox-1.8) (Homeobox protein Hox-1H) (PL) | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to the DNA sequence 5'-AA[AT]TTTTATTAC-3'. |
| P35221 | CTNNA1 | S323 | ochoa | Catenin alpha-1 (Alpha E-catenin) (Cadherin-associated protein) (Renal carcinoma antigen NY-REN-13) | Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). May play a crucial role in cell differentiation. {ECO:0000250|UniProtKB:P26231, ECO:0000269|PubMed:25653389}. |
| P40189 | IL6ST | Y767 | psp | Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (CDw130) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130) | Signal-transducing molecule (PubMed:2261637). The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates the intracellular JAK-MAPK and JAK-STAT3 signaling pathways (PubMed:19915009, PubMed:2261637, PubMed:23294003). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:19915009, PubMed:23294003, PubMed:25731159). In parallel, the IL6 signaling pathway induces the expression of two cytokine receptor signaling inhibitors, SOCS1 and SOCS3, which inhibit JAK and terminate the activity of the IL6 signaling pathway as a negative feedback loop (By similarity). Also activates the yes-associated protein 1 (YAP) and NOTCH pathways to control inflammation-induced epithelial regeneration, independently of STAT3 (By similarity). Acts as a receptor for the neuroprotective peptide humanin as part of a complex with IL27RA/WSX1 and CNTFR (PubMed:19386761). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity). Has a role in embryonic development (By similarity). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity). Required for expression of TRPA1 in nociceptive neurons (By similarity). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity). Required for normal trabecular bone mass and cortical bone composition (By similarity). {ECO:0000250|UniProtKB:Q00560, ECO:0000269|PubMed:19386761, ECO:0000269|PubMed:19915009, ECO:0000269|PubMed:2261637, ECO:0000269|PubMed:23294003, ECO:0000269|PubMed:25731159, ECO:0000269|PubMed:28747427, ECO:0000269|PubMed:30309848}.; FUNCTION: [Isoform 2]: Binds to the soluble IL6:sIL6R complex (hyper-IL6), thereby blocking IL6 trans-signaling. Inhibits sIL6R-dependent acute phase response (PubMed:11121117, PubMed:21990364, PubMed:30279168). Also blocks IL11 cluster signaling through IL11R (PubMed:30279168). {ECO:0000269|PubMed:11121117, ECO:0000269|PubMed:21990364, ECO:0000269|PubMed:30279168}. |
| P40692 | MLH1 | S374 | ochoa | DNA mismatch repair protein Mlh1 (MutL protein homolog 1) | Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma which plays a role in meiosis. {ECO:0000269|PubMed:16873062, ECO:0000269|PubMed:18206974, ECO:0000269|PubMed:20020535, ECO:0000269|PubMed:21120944, ECO:0000269|PubMed:39032648, ECO:0000269|PubMed:9311737}. |
| P48552 | NRIP1 | S564 | ochoa | Nuclear receptor-interacting protein 1 (Nuclear factor RIP140) (Receptor-interacting protein 140) | Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function (By similarity). Plays a role in renal development (PubMed:28381549). {ECO:0000250|UniProtKB:Q8CBD1, ECO:0000269|PubMed:10364267, ECO:0000269|PubMed:11509661, ECO:0000269|PubMed:11518808, ECO:0000269|PubMed:12554755, ECO:0000269|PubMed:15060175, ECO:0000269|PubMed:21628546, ECO:0000269|PubMed:28381549, ECO:0000269|PubMed:7641693}. |
| P49790 | NUP153 | S562 | ochoa | Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}. |
| P49848 | TAF6 | S598 | ochoa | Transcription initiation factor TFIID subunit 6 (RNA polymerase II TBP-associated factor subunit E) (Transcription initiation factor TFIID 70 kDa subunit) (TAF(II)70) (TAFII-70) (TAFII70) (Transcription initiation factor TFIID 80 kDa subunit) (TAF(II)80) (TAFII-80) (TAFII80) | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (PubMed:33795473). TAF6 homodimer connects TFIID modules, forming a rigid core (PubMed:33795473). {ECO:0000269|PubMed:33795473}.; FUNCTION: [Isoform 4]: Transcriptional regulator which acts primarily as a positive regulator of transcription (PubMed:20096117, PubMed:29358700). Recruited to the promoters of a number of genes including GADD45A and CDKN1A/p21, leading to transcriptional up-regulation and subsequent induction of apoptosis (PubMed:11583621). Also up-regulates expression of other genes including GCNA/ACRC, HES1 and IFFO1 (PubMed:18628956). In contrast, down-regulates transcription of MDM2 (PubMed:11583621). Acts as a transcriptional coactivator to enhance transcription of TP53/p53-responsive genes such as DUSP1 (PubMed:20096117). Can also activate transcription and apoptosis independently of TP53 (PubMed:18628956). Drives apoptosis via the intrinsic apoptotic pathway by up-regulating apoptosis effectors such as BCL2L11/BIM and PMAIP1/NOXA (PubMed:29358700). {ECO:0000269|PubMed:11583621, ECO:0000269|PubMed:18628956, ECO:0000269|PubMed:20096117, ECO:0000269|PubMed:29358700}. |
| P50552 | VASP | S46 | ochoa | Vasodilator-stimulated phosphoprotein (VASP) | Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation. {ECO:0000269|PubMed:10087267, ECO:0000269|PubMed:10438535, ECO:0000269|PubMed:15939738, ECO:0000269|PubMed:17082196, ECO:0000269|PubMed:18559661}. |
| P54252 | ATXN3 | S335 | psp | Ataxin-3 (EC 3.4.19.12) (Machado-Joseph disease protein 1) (Spinocerebellar ataxia type 3 protein) | Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates (PubMed:12297501, PubMed:16118278, PubMed:17696782, PubMed:23625928, PubMed:28445460, PubMed:33157014). Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (PubMed:17696782). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By similarity). Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription (PubMed:12297501). Acts as a negative regulator of mTORC1 signaling in response to amino acid deprivation by mediating deubiquitination of RHEB, thereby promoting RHEB inactivation by the TSC-TBC complex (PubMed:33157014). Regulates autophagy via the deubiquitination of 'Lys-402' of BECN1 leading to the stabilization of BECN1 (PubMed:28445460). {ECO:0000250|UniProtKB:Q9CVD2, ECO:0000269|PubMed:12297501, ECO:0000269|PubMed:16118278, ECO:0000269|PubMed:17696782, ECO:0000269|PubMed:23625928, ECO:0000269|PubMed:28445460, ECO:0000269|PubMed:33157014}. |
| P56270 | MAZ | S414 | ochoa | Myc-associated zinc finger protein (MAZI) (Pur-1) (Purine-binding transcription factor) (Serum amyloid A-activating factor-1) (SAF-1) (Transcription factor Zif87) (ZF87) (Zinc finger protein 801) | Transcriptional regulator, potentially with dual roles in transcription initiation and termination. {ECO:0000303|PubMed:1502157}.; FUNCTION: [Isoform 1]: Binds DNA and functions as a transcriptional activator (PubMed:12270922). Binds to two G/A-rich sites, ME1a1 and ME1a2, within the MYC promoter having greater affinity for the former (PubMed:1502157). Also binds to multiple G/C-rich sites within the promoter of the Sp1 family of transcription factors (PubMed:1502157). {ECO:0000269|PubMed:12270922, ECO:0000269|PubMed:1502157}.; FUNCTION: [Isoform 2]: Binds DNA and functions as a transcriptional activator (PubMed:12270922). Inhibits MAZ isoform 1-mediated transcription (PubMed:12270922). {ECO:0000269|PubMed:12270922}.; FUNCTION: [Isoform 3]: Binds DNA and functions as a transcriptional activator. {ECO:0000269|PubMed:19583771}. |
| P98160 | HSPG2 | S105 | ochoa | Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG) (Perlecan) (PLC) [Cleaved into: Endorepellin; LG3 peptide] | Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development.; FUNCTION: [Endorepellin]: Anti-angiogenic and anti-tumor peptide that inhibits endothelial cell migration, collagen-induced endothelial tube morphogenesis and blood vessel growth in the chorioallantoic membrane. Blocks endothelial cell adhesion to fibronectin and type I collagen. Anti-tumor agent in neovascularization. Interaction with its ligand, integrin alpha2/beta1, is required for the anti-angiogenic properties. Evokes a reduction in phosphorylation of receptor tyrosine kinases via alpha2/beta1 integrin-mediated activation of the tyrosine phosphatase, PTPN6.; FUNCTION: [LG3 peptide]: Has anti-angiogenic properties that require binding of calcium ions for full activity. |
| P98160 | HSPG2 | S2402 | ochoa | Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG) (Perlecan) (PLC) [Cleaved into: Endorepellin; LG3 peptide] | Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development.; FUNCTION: [Endorepellin]: Anti-angiogenic and anti-tumor peptide that inhibits endothelial cell migration, collagen-induced endothelial tube morphogenesis and blood vessel growth in the chorioallantoic membrane. Blocks endothelial cell adhesion to fibronectin and type I collagen. Anti-tumor agent in neovascularization. Interaction with its ligand, integrin alpha2/beta1, is required for the anti-angiogenic properties. Evokes a reduction in phosphorylation of receptor tyrosine kinases via alpha2/beta1 integrin-mediated activation of the tyrosine phosphatase, PTPN6.; FUNCTION: [LG3 peptide]: Has anti-angiogenic properties that require binding of calcium ions for full activity. |
| P98160 | HSPG2 | S2691 | ochoa | Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG) (Perlecan) (PLC) [Cleaved into: Endorepellin; LG3 peptide] | Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development.; FUNCTION: [Endorepellin]: Anti-angiogenic and anti-tumor peptide that inhibits endothelial cell migration, collagen-induced endothelial tube morphogenesis and blood vessel growth in the chorioallantoic membrane. Blocks endothelial cell adhesion to fibronectin and type I collagen. Anti-tumor agent in neovascularization. Interaction with its ligand, integrin alpha2/beta1, is required for the anti-angiogenic properties. Evokes a reduction in phosphorylation of receptor tyrosine kinases via alpha2/beta1 integrin-mediated activation of the tyrosine phosphatase, PTPN6.; FUNCTION: [LG3 peptide]: Has anti-angiogenic properties that require binding of calcium ions for full activity. |
| P98171 | ARHGAP4 | S408 | ochoa | Rho GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (Rho-type GTPase-activating protein 4) (p115) | Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells. |
| Q03468 | ERCC6 | S1115 | ochoa | DNA excision repair protein ERCC-6 (EC 3.6.4.-) (ATP-dependent helicase ERCC6) (Cockayne syndrome protein CSB) | Essential factor involved in transcription-coupled nucleotide excision repair (TC-NER), a process during which RNA polymerase II-blocking lesions are rapidly removed from the transcribed strand of active genes (PubMed:16246722, PubMed:20541997, PubMed:22483866, PubMed:26620705, PubMed:32355176, PubMed:34526721, PubMed:38316879, PubMed:38600235, PubMed:38600236). Plays a central role in the initiation of the TC-NER process: specifically recognizes and binds RNA polymerase II stalled at a lesion, and mediates recruitment of ERCC8/CSA, initiating DNA damage excision by TFIIH recruitment (PubMed:32355176, PubMed:34526721, PubMed:38600235, PubMed:38600236). Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA (PubMed:15548521). Acts as a chromatin remodeler at DSBs; DNA-dependent ATPase-dependent activity is essential for this function (PubMed:16246722, PubMed:9565609). Plays an important role in regulating the choice of the DNA double-strand breaks (DSBs) repair pathway and G2/M checkpoint activation; DNA-dependent ATPase activity is essential for this function (PubMed:25820262). Regulates the DNA repair pathway choice by inhibiting non-homologous end joining (NHEJ), thereby promoting the homologous recombination (HR)-mediated repair of DSBs during the S/G2 phases of the cell cycle (PubMed:25820262). Mediates the activation of the ATM- and CHEK2-dependent DNA damage responses thus preventing premature entry of cells into mitosis following the induction of DNA DSBs (PubMed:25820262). Remodels chromatin by evicting histones from chromatin flanking DSBs, limiting RIF1 accumulation at DSBs thereby promoting BRCA1-mediated HR (PubMed:29203878). Required for stable recruitment of ELOA and CUL5 to DNA damage sites (PubMed:28292928). Also involved in UV-induced translocation of ERCC8 to the nuclear matrix (PubMed:26620705). Essential for neuronal differentiation and neuritogenesis; regulates transcription and chromatin remodeling activities required during neurogenesis (PubMed:24874740). {ECO:0000269|PubMed:15548521, ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:20541997, ECO:0000269|PubMed:22483866, ECO:0000269|PubMed:24874740, ECO:0000269|PubMed:25820262, ECO:0000269|PubMed:26620705, ECO:0000269|PubMed:28292928, ECO:0000269|PubMed:29203878, ECO:0000269|PubMed:32355176, ECO:0000269|PubMed:34526721, ECO:0000269|PubMed:38316879, ECO:0000269|PubMed:38600235, ECO:0000269|PubMed:38600236, ECO:0000269|PubMed:9565609}. |
| Q06413 | MEF2C | S396 | ochoa|psp | Myocyte-specific enhancer factor 2C (Myocyte enhancer factor 2C) | Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoforms that lack the repressor domain are more active than isoform 1. {ECO:0000250|UniProtKB:Q8CFN5, ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:15340086, ECO:0000269|PubMed:15831463, ECO:0000269|PubMed:15834131, ECO:0000269|PubMed:9069290, ECO:0000269|PubMed:9384584}. |
| Q12778 | FOXO1 | S394 | psp | Forkhead box protein O1 (Forkhead box protein O1A) (Forkhead in rhabdomyosarcoma) | Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress (PubMed:10358076, PubMed:12228231, PubMed:15220471, PubMed:15890677, PubMed:18356527, PubMed:19221179, PubMed:20543840, PubMed:21245099). Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3' (PubMed:10358076). Activity suppressed by insulin (PubMed:10358076). Main regulator of redox balance and osteoblast numbers and controls bone mass (By similarity). Orchestrates the endocrine function of the skeleton in regulating glucose metabolism (By similarity). Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity (By similarity). Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP (By similarity). Acts as an inhibitor of glucose sensing in pancreatic beta cells by acting as a transcription repressor and suppressing expression of PDX1 (By similarity). In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC1 and PCK1 (By similarity). Also promotes gluconeogenesis by directly promoting expression of PPARGC1A and G6PC1 (PubMed:17024043). Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and STK4/MST1 (PubMed:18356527, PubMed:19221179). Promotes neural cell death (PubMed:18356527). Mediates insulin action on adipose tissue (By similarity). Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake (By similarity). Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells (By similarity). Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner (PubMed:20543840). Mediates the function of MLIP in cardiomyocytes hypertrophy and cardiac remodeling (By similarity). Positive regulator of apoptosis in cardiac smooth muscle cells as a result of its transcriptional activation of pro-apoptotic genes (PubMed:19483080). Regulates endothelial cell (EC) viability and apoptosis in a PPIA/CYPA-dependent manner via transcription of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (PubMed:31063815). {ECO:0000250|UniProtKB:A4L7N3, ECO:0000250|UniProtKB:G3V7R4, ECO:0000250|UniProtKB:Q9R1E0, ECO:0000269|PubMed:10358076, ECO:0000269|PubMed:12228231, ECO:0000269|PubMed:15220471, ECO:0000269|PubMed:15890677, ECO:0000269|PubMed:17024043, ECO:0000269|PubMed:18356527, ECO:0000269|PubMed:19221179, ECO:0000269|PubMed:19483080, ECO:0000269|PubMed:20543840, ECO:0000269|PubMed:21245099, ECO:0000269|PubMed:31063815}. |
| Q12888 | TP53BP1 | S25 | psp | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q13422 | IKZF1 | S389 | ochoa | DNA-binding protein Ikaros (Ikaros family zinc finger protein 1) (Lymphoid transcription factor LyF-1) | Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067). {ECO:0000250|UniProtKB:Q03267, ECO:0000269|PubMed:10204490, ECO:0000269|PubMed:17135265, ECO:0000269|PubMed:17934067, ECO:0000269|PubMed:19141594}. |
| Q13426 | XRCC4 | S256 | ochoa | DNA repair protein XRCC4 (hXRCC4) (X-ray repair cross-complementing protein 4) [Cleaved into: Protein XRCC4, C-terminus (XRCC4/C)] | [DNA repair protein XRCC4]: DNA non-homologous end joining (NHEJ) core factor, required for double-strand break repair and V(D)J recombination (PubMed:10757784, PubMed:10854421, PubMed:12517771, PubMed:16412978, PubMed:17124166, PubMed:17290226, PubMed:22228831, PubMed:25597996, PubMed:25742519, PubMed:25934149, PubMed:26100018, PubMed:26774286, PubMed:8548796). Acts as a scaffold protein that regulates recruitment of other proteins to DNA double-strand breaks (DSBs) (PubMed:15385968, PubMed:20852255, PubMed:26774286, PubMed:27437582). Associates with NHEJ1/XLF to form alternating helical filaments that bridge DNA and act like a bandage, holding together the broken DNA until it is repaired (PubMed:21768349, PubMed:21775435, PubMed:22287571, PubMed:26100018, PubMed:27437582, PubMed:28500754). The XRCC4-NHEJ1/XLF subcomplex binds to the DNA fragments of a DSB in a highly diffusive manner and robustly bridges two independent DNA molecules, holding the broken DNA fragments in close proximity to one other (PubMed:27437582). The mobility of the bridges ensures that the ends remain accessible for further processing by other repair factors (PubMed:27437582). Plays a key role in the NHEJ ligation step of the broken DNA during DSB repair via direct interaction with DNA ligase IV (LIG4): the LIG4-XRCC4 subcomplex reseals the DNA breaks after the gap filling is completed (PubMed:10757784, PubMed:10854421, PubMed:12517771, PubMed:17290226, PubMed:19837014, PubMed:9242410). XRCC4 stabilizes LIG4, regulates its subcellular localization and enhances LIG4's joining activity (PubMed:10757784, PubMed:10854421, PubMed:12517771, PubMed:17290226, PubMed:21982441, PubMed:22228831, PubMed:9242410). Binding of the LIG4-XRCC4 subcomplex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends (PubMed:10757784, PubMed:10854421). Promotes displacement of PNKP from processed strand break termini (PubMed:20852255, PubMed:28453785). {ECO:0000269|PubMed:10757784, ECO:0000269|PubMed:10854421, ECO:0000269|PubMed:12517771, ECO:0000269|PubMed:15385968, ECO:0000269|PubMed:16412978, ECO:0000269|PubMed:17124166, ECO:0000269|PubMed:17290226, ECO:0000269|PubMed:19837014, ECO:0000269|PubMed:20852255, ECO:0000269|PubMed:21768349, ECO:0000269|PubMed:21775435, ECO:0000269|PubMed:21982441, ECO:0000269|PubMed:22228831, ECO:0000269|PubMed:22287571, ECO:0000269|PubMed:25597996, ECO:0000269|PubMed:25742519, ECO:0000269|PubMed:25934149, ECO:0000269|PubMed:26100018, ECO:0000269|PubMed:26774286, ECO:0000269|PubMed:27437582, ECO:0000269|PubMed:28453785, ECO:0000269|PubMed:28500754, ECO:0000269|PubMed:8548796, ECO:0000269|PubMed:9242410}.; FUNCTION: [Protein XRCC4, C-terminus]: Acts as an activator of the phospholipid scramblase activity of XKR4 (PubMed:33725486). This form, which is generated upon caspase-3 (CASP3) cleavage, translocates into the cytoplasm and interacts with XKR4, thereby promoting phosphatidylserine scramblase activity of XKR4 and leading to phosphatidylserine exposure on apoptotic cell surface (PubMed:33725486). {ECO:0000269|PubMed:33725486}. |
| Q13459 | MYO9B | S83 | ochoa | Unconventional myosin-IXb (Unconventional myosin-9b) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:26529257, PubMed:9490638). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). {ECO:0000269|PubMed:26529257, ECO:0000269|PubMed:9490638}. |
| Q13530 | SERINC3 | S371 | ochoa | Serine incorporator 3 (Tumor differentially expressed protein 1) | Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm (PubMed:26416733, PubMed:26416734). Non-ATP-dependent, non-specific lipid transporter for phosphatidylserine, phosphatidylcholine, and phosphatidylethanolamine. Functions as a scramblase that flips lipids in both directions across the membrane. Phospholipid scrambling results in HIV-1 surface exposure of phosphatidylserine and loss of membrane asymmetry, which leads to changes in HIV-1 Env conformation and loss of infectivity (PubMed:37474505). {ECO:0000269|PubMed:26416733, ECO:0000269|PubMed:26416734, ECO:0000269|PubMed:37474505}. |
| Q13724 | MOGS | S736 | ochoa | Mannosyl-oligosaccharide glucosidase (EC 3.2.1.106) (Processing A-glucosidase I) | In the context of N-glycan degradation, cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor in a highly specific manner. {ECO:0000269|PubMed:7635146}. |
| Q14191 | WRN | S1400 | ochoa | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (DNA helicase, RecQ-like type 3) (RecQ protein-like 2) (Werner syndrome protein) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)] | Multifunctional enzyme that has magnesium and ATP-dependent 3'-5' DNA-helicase activity on partially duplex substrates (PubMed:9224595, PubMed:9288107, PubMed:9611231). Also has 3'->5' exonuclease activity towards double-stranded (ds)DNA with a 5'-overhang (PubMed:11863428). Has no nuclease activity towards single-stranded (ss)DNA or blunt-ended dsDNA (PubMed:11863428). Helicase activity is most efficient with (d)ATP, but (d)CTP will substitute with reduced efficiency; strand displacement is enhanced by single-strand binding-protein (heterotrimeric replication protein A complex, RPA1, RPA2, RPA3) (PubMed:9611231). Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A (By similarity). Plays a role in double-strand break repair after gamma-irradiation (PubMed:9224595, PubMed:9288107, PubMed:9611231). Unwinds some G-quadruplex DNA (d(CGG)n tracts); unwinding seems to occur in both 5'-3' and 3'-5' direction and requires a short single-stranded tail (PubMed:10212265). d(CGG)n tracts have a propensity to assemble into tetraplex structures; other G-rich substrates from a telomeric or IgG switch sequence are not unwound (PubMed:10212265). Depletion leads to chromosomal breaks and genome instability (PubMed:33199508). {ECO:0000250|UniProtKB:O09053, ECO:0000269|PubMed:10212265, ECO:0000269|PubMed:11863428, ECO:0000269|PubMed:17563354, ECO:0000269|PubMed:18596042, ECO:0000269|PubMed:19283071, ECO:0000269|PubMed:19652551, ECO:0000269|PubMed:21639834, ECO:0000269|PubMed:27063109, ECO:0000269|PubMed:33199508, ECO:0000269|PubMed:9224595, ECO:0000269|PubMed:9288107, ECO:0000269|PubMed:9611231}. |
| Q14207 | NPAT | S539 | ochoa | Protein NPAT (Nuclear protein of the ataxia telangiectasia mutated locus) (Nuclear protein of the ATM locus) (p220) | Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters. {ECO:0000269|PubMed:10995386, ECO:0000269|PubMed:10995387, ECO:0000269|PubMed:12665581, ECO:0000269|PubMed:12724424, ECO:0000269|PubMed:14585971, ECO:0000269|PubMed:14612403, ECO:0000269|PubMed:15555599, ECO:0000269|PubMed:15988025, ECO:0000269|PubMed:16131487, ECO:0000269|PubMed:17163457, ECO:0000269|PubMed:17826007, ECO:0000269|PubMed:17967892, ECO:0000269|PubMed:17974976, ECO:0000269|PubMed:9472014}. |
| Q14242 | SELPLG | S389 | ochoa | P-selectin glycoprotein ligand 1 (PSGL-1) (Selectin P ligand) (CD antigen CD162) | A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture. {ECO:0000269|PubMed:11566773, ECO:0000269|PubMed:12403782}.; FUNCTION: (Microbial infection) Acts as a receptor for enterovirus 71. {ECO:0000269|PubMed:19543284}. |
| Q14644 | RASA3 | S528 | ochoa | Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) | Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) with high affinity. Might be a specific IP4 receptor. |
| Q15057 | ACAP2 | S581 | ochoa | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 (Centaurin-beta-2) (Cnt-b2) | GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6). Doesn't show GAP activity for RAB35 (PubMed:30905672). {ECO:0000269|PubMed:11062263, ECO:0000269|PubMed:30905672}. |
| Q15435 | PPP1R7 | S322 | ochoa | Protein phosphatase 1 regulatory subunit 7 (Protein phosphatase 1 regulatory subunit 22) | Regulatory subunit of protein phosphatase 1. {ECO:0000250}. |
| Q15648 | MED1 | S1347 | ochoa | Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}. |
| Q15750 | TAB1 | S457 | psp | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 1) (TGF-beta-activated kinase 1-binding protein 1) (TAK1-binding protein 1) | Key adapter protein that plays an essential role in JNK and NF-kappa-B activation and proinflammatory cytokines production in response to stimulation with TLRs and cytokines (PubMed:22307082, PubMed:24403530). Mechanistically, associates with the catalytic domain of MAP3K7/TAK1 to trigger MAP3K7/TAK1 autophosphorylation leading to its full activation (PubMed:10838074, PubMed:25260751, PubMed:37832545). Similarly, associates with MAPK14 and triggers its autophosphorylation and subsequent activation (PubMed:11847341, PubMed:29229647). In turn, MAPK14 phosphorylates TAB1 and inhibits MAP3K7/TAK1 activation in a feedback control mechanism (PubMed:14592977). Also plays a role in recruiting MAPK14 to the TAK1 complex for the phosphorylation of the TAB2 and TAB3 regulatory subunits (PubMed:18021073). {ECO:0000269|PubMed:10838074, ECO:0000269|PubMed:11847341, ECO:0000269|PubMed:14592977, ECO:0000269|PubMed:18021073, ECO:0000269|PubMed:22307082, ECO:0000269|PubMed:24403530, ECO:0000269|PubMed:25260751, ECO:0000269|PubMed:29229647, ECO:0000269|PubMed:37832545}. |
| Q15911 | ZFHX3 | S2230 | ochoa | Zinc finger homeobox protein 3 (AT motif-binding factor 1) (AT-binding transcription factor 1) (Alpha-fetoprotein enhancer-binding protein) (Zinc finger homeodomain protein 3) (ZFH-3) | Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3 (PubMed:25105025). Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain (By similarity). Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression (PubMed:11312261). Down-regulates the MUC5AC promoter in gastric cancer (PubMed:17330845). In association with RUNX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). Inhibits estrogen receptor (ESR1) function by selectively competing with coactivator NCOA3 for binding to ESR1 in ESR1-positive breast cancer cells (PubMed:20720010). {ECO:0000250|UniProtKB:Q61329, ECO:0000269|PubMed:11312261, ECO:0000269|PubMed:17330845, ECO:0000269|PubMed:20599712, ECO:0000269|PubMed:20720010, ECO:0000269|PubMed:25105025}. |
| Q2KHR3 | QSER1 | S886 | ochoa | Glutamine and serine-rich protein 1 | Plays an essential role in the protection and maintenance of transcriptional and developmental programs. Protects many bivalent promoters and poised enhancers from hypermethylation, showing a marked preference for these regulatory elements over other types of promoters or enhancers. Mechanistically, cooperates with TET1 and binds to DNA in a common complex to inhibit the binding of DNMT3A/3B and therefore de novo methylation. {ECO:0000269|PubMed:33833093}. |
| Q32MZ4 | LRRFIP1 | S116 | ochoa | Leucine-rich repeat flightless-interacting protein 1 (LRR FLII-interacting protein 1) (GC-binding factor 2) (TAR RNA-interacting protein) | Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:10364563, ECO:0000269|PubMed:14522076, ECO:0000269|PubMed:16199883, ECO:0000269|PubMed:19265123, ECO:0000269|PubMed:9705290}. |
| Q3KR37 | GRAMD1B | S274 | ochoa | Protein Aster-B (GRAM domain-containing protein 1B) | Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis in the adrenal gland and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). {ECO:0000250|UniProtKB:Q80TI0}. |
| Q4VX76 | SYTL3 | S586 | ochoa | Synaptotagmin-like protein 3 (Exophilin-6) | May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids in the presence of calcium ions (By similarity). {ECO:0000250}. |
| Q58EX2 | SDK2 | S2054 | ochoa | Protein sidekick-2 | Adhesion molecule that promotes lamina-specific synaptic connections in the retina and is specifically required for the formation of neuronal circuits that detect motion. Acts by promoting formation of synapses between two specific retinal cell types: the retinal ganglion cells W3B-RGCs and the excitatory amacrine cells VG3-ACs. Formation of synapses between these two cells plays a key role in detection of motion. Promotes synaptic connectivity via homophilic interactions. {ECO:0000250|UniProtKB:Q6V4S5}. |
| Q5CZC0 | FSIP2 | S3181 | ochoa | Fibrous sheath-interacting protein 2 | Plays a role in spermatogenesis. {ECO:0000305|PubMed:30137358}. |
| Q5SGD2 | PPM1L | S213 | ochoa | Protein phosphatase 1L (EC 3.1.3.16) (Protein phosphatase 1-like) (Protein phosphatase 2C isoform epsilon) (PP2C-epsilon) | Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6. {ECO:0000269|PubMed:17456047}. |
| Q5T1R4 | HIVEP3 | S933 | ochoa | Transcription factor HIVEP3 (Human immunodeficiency virus type I enhancer-binding protein 3) (Kappa-B and V(D)J recombination signal sequences-binding protein) (Kappa-binding protein 1) (KBP-1) (Zinc finger protein ZAS3) | Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Also binds to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and pro-inflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation. {ECO:0000269|PubMed:11161801}. |
| Q5T5Y3 | CAMSAP1 | S1196 | ochoa | Calmodulin-regulated spectrin-associated protein 1 | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19508979, PubMed:21834987, PubMed:24117850, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and stabilizes microtubules (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation (PubMed:24486153, PubMed:24706919). Through interaction with spectrin may regulate neurite outgrowth (PubMed:24117850). {ECO:0000269|PubMed:19508979, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:24117850, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919}. |
| Q5U5Q3 | MEX3C | S446 | ochoa | RNA-binding E3 ubiquitin-protein ligase MEX3C (EC 2.3.2.27) (RING finger and KH domain-containing protein 2) (RING finger protein 194) (RING-type E3 ubiquitin transferase MEX3C) | E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation. {ECO:0000269|PubMed:22863774, ECO:0000269|PubMed:23446422}. |
| Q5UIP0 | RIF1 | S2243 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5VT06 | CEP350 | S2460 | ochoa | Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) | Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CPAP (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}. |
| Q5VZ46 | KIAA1614 | S964 | ochoa | Uncharacterized protein KIAA1614 | None |
| Q5VZP5 | STYXL2 | S985 | ochoa | Serine/threonine/tyrosine-interacting-like protein 2 (Inactive dual specificity phosphatase 27) | May be required for myofiber maturation. {ECO:0000250|UniProtKB:F1QWM2}. |
| Q68CP9 | ARID2 | S1470 | ochoa | AT-rich interactive domain-containing protein 2 (ARID domain-containing protein 2) (BRG1-associated factor 200) (BAF200) (Zinc finger protein with activation potential) (Zipzap/p200) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). May be involved in targeting the complex to different genes. May be involved in regulating transcriptional activation of cardiac genes. {ECO:0000269|PubMed:16782067, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q68DQ2 | CRYBG3 | S679 | ochoa | Very large A-kinase anchor protein (vlAKAP) (Beta/gamma crystallin domain-containing protein 3) | [Isoform vlAKAP]: Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA). {ECO:0000269|PubMed:25097019}. |
| Q6EMB2 | TTLL5 | S1103 | ochoa | Tubulin polyglutamylase TTLL5 (EC 6.3.2.-) (SRC1 and TIF2-associated modulatory protein) (STAMP protein) (Tubulin--tyrosine ligase-like protein 5) | Polyglutamylase which modifies tubulin, generating polyglutamate side chains on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin. Preferentially mediates ATP-dependent initiation step of the polyglutamylation reaction over the elongation step. Preferentially modifies the alpha-tubulin tail over a beta-tail (By similarity). Required for CCSAP localization to both polyglutamylated spindle and cilia microtubules (PubMed:22493317). Increases the effects of transcriptional coactivator NCOA2/TIF2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction (PubMed:17116691). {ECO:0000250|UniProtKB:Q8CHB8, ECO:0000269|PubMed:17116691, ECO:0000269|PubMed:22493317}. |
| Q6KC79 | NIPBL | S850 | ochoa | Nipped-B-like protein (Delangin) (SCC2 homolog) | Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}. |
| Q6UB98 | ANKRD12 | S1255 | ochoa | Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein) | May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation. |
| Q6UB98 | ANKRD12 | S1372 | ochoa | Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein) | May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation. |
| Q6UB99 | ANKRD11 | S1757 | ochoa | Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1) | Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). {ECO:0000250|UniProtKB:E9Q4F7, ECO:0000269|PubMed:15184363, ECO:0000269|PubMed:25556659}. |
| Q6UWF9 | FAM180A | S112 | ochoa | Protein FAM180A | None |
| Q6WKZ4 | RAB11FIP1 | S389 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
| Q6ZSZ6 | TSHZ1 | S626 | ochoa | Teashirt homolog 1 (Antigen NY-CO-33) (Serologically defined colon cancer antigen 33) | Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential). {ECO:0000305}. |
| Q6ZSZ6 | TSHZ1 | S919 | ochoa | Teashirt homolog 1 (Antigen NY-CO-33) (Serologically defined colon cancer antigen 33) | Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential). {ECO:0000305}. |
| Q6ZUJ8 | PIK3AP1 | S174 | ochoa | Phosphoinositide 3-kinase adapter protein 1 (B-cell adapter for phosphoinositide 3-kinase) (B-cell phosphoinositide 3-kinase adapter protein 1) | Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL. {ECO:0000269|PubMed:15893754}. |
| Q6ZVL6 | KIAA1549L | S1310 | ochoa | UPF0606 protein KIAA1549L | None |
| Q70CQ2 | USP34 | S681 | ochoa | Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.4.19.12) (Deubiquitinating enzyme 34) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) | Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. {ECO:0000269|PubMed:21383061}. |
| Q70CQ4 | USP31 | S803 | ochoa | Ubiquitin carboxyl-terminal hydrolase 31 (EC 3.4.19.12) (Deubiquitinating enzyme 31) (Ubiquitin thioesterase 31) (Ubiquitin-specific-processing protease 31) | Deubiquitinase that recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. May play a role in the regulation of NF-kappa-B signaling pathway by deubiquitinating TRAF2. {ECO:0000269|PubMed:34184746}.; FUNCTION: (Microbial infection) Plays a positive role in foot-and-mouth disease and classical swine fever viral infection. Mechanistically, associates with internal ribosomal entry site (IRES) element within the 5'-untranslated region of viral genomes to promote translation of the virus-encoded polyprotein. {ECO:0000269|PubMed:35468926}. |
| Q70CQ4 | USP31 | S1060 | ochoa | Ubiquitin carboxyl-terminal hydrolase 31 (EC 3.4.19.12) (Deubiquitinating enzyme 31) (Ubiquitin thioesterase 31) (Ubiquitin-specific-processing protease 31) | Deubiquitinase that recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. May play a role in the regulation of NF-kappa-B signaling pathway by deubiquitinating TRAF2. {ECO:0000269|PubMed:34184746}.; FUNCTION: (Microbial infection) Plays a positive role in foot-and-mouth disease and classical swine fever viral infection. Mechanistically, associates with internal ribosomal entry site (IRES) element within the 5'-untranslated region of viral genomes to promote translation of the virus-encoded polyprotein. {ECO:0000269|PubMed:35468926}. |
| Q71F56 | MED13L | S522 | ochoa | Mediator of RNA polymerase II transcription subunit 13-like (Mediator complex subunit 13-like) (Thyroid hormone receptor-associated protein 2) (Thyroid hormone receptor-associated protein complex 240 kDa component-like) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. |
| Q7L804 | RAB11FIP2 | S270 | ochoa | Rab11 family-interacting protein 2 (Rab11-FIP2) (NRip11) | A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity. Plays an essential role in phagocytosis through a mechanism involving TICAM2, RAC1 and CDC42 Rho GTPases for controlling actin-dynamics. {ECO:0000269|PubMed:12364336, ECO:0000269|PubMed:15304524, ECO:0000269|PubMed:16251358, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:19542231, ECO:0000269|PubMed:30883606}. |
| Q7LFL8 | CXXC5 | S84 | ochoa | CXXC-type zinc finger protein 5 (CF5) (Putative MAPK-activating protein PM08) (Putative NF-kappa-B-activating protein 102) (Retinoid-inducible nuclear factor) (RINF) | May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (By similarity). Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. Transcription factor. Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (PubMed:23303788). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (PubMed:29276034). {ECO:0000250|UniProtKB:Q5XIQ3, ECO:0000269|PubMed:19182210, ECO:0000269|PubMed:19557330, ECO:0000269|PubMed:23303788, ECO:0000269|PubMed:29276034}. |
| Q7Z3G6 | PRICKLE2 | S319 | ochoa | Prickle-like protein 2 | None |
| Q7Z569 | BRAP | S286 | ochoa | BRCA1-associated protein (EC 2.3.2.27) (BRAP2) (Impedes mitogenic signal propagation) (IMP) (RING finger protein 52) (RING-type E3 ubiquitin transferase BRAP2) (Renal carcinoma antigen NY-REN-63) | Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport. {ECO:0000269|PubMed:14724641, ECO:0000303|PubMed:10777491}. |
| Q7Z6J6 | FRMD5 | S375 | ochoa | FERM domain-containing protein 5 | May be involved in regulation of cell migration (PubMed:22846708, PubMed:25448675). May regulate cell-matrix interactions via its interaction with ITGB5 and modifying ITGB5 cytoplasmic tail interactions such as with FERMT2 and TLN1. May regulate ROCK1 kinase activity possibly involved in regulation of actin stress fiber formation (PubMed:25448675). |
| Q86XP1 | DGKH | S318 | ochoa | Diacylglycerol kinase eta (DAG kinase eta) (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) | Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:12810723, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable) (PubMed:12810723, PubMed:23949095). Plays a key role in promoting cell growth (PubMed:19710016). Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF (PubMed:19710016). Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization (PubMed:19710016). {ECO:0000269|PubMed:12810723, ECO:0000269|PubMed:19710016, ECO:0000269|PubMed:23949095, ECO:0000305}. |
| Q86XR7 | TICAM2 | S26 | ochoa | TIR domain-containing adapter molecule 2 (TICAM-2) (Putative NF-kappa-B-activating protein 502) (TRIF-related adapter molecule) (Toll-like receptor adaptor protein 3) (Toll/interleukin-1 receptor domain-containing protein) (MyD88-4) | Functions as a sorting adapter in different signaling pathways to facilitate downstream signaling leading to type I interferon induction (PubMed:16603631, PubMed:16757566, PubMed:25385819, PubMed:25825441). In TLR4 signaling, physically bridges TLR4 and TICAM1 and functionally transmits signal to TICAM1 in early endosomes after endocytosis of TLR4. In TLR2 signaling, physically bridges TLR2 and MYD88 and is required for the TLR2-dependent movement of MYD88 to endosomes following ligand engagement (PubMed:25385819). Involved in IL-18 signaling and is proposed to function as a sorting adapter for MYD88 in IL-18 signaling during adaptive immune response (PubMed:22685567). Forms a complex with RAB11FIP2 that is recruited to the phagosomes to promote the activation of the actin-regulatory GTPases RAC1 and CDC42 and subsequent phagocytosis of Gram-negative bacteria (PubMed:30883606). {ECO:0000269|PubMed:16603631, ECO:0000269|PubMed:16757566, ECO:0000269|PubMed:22685567, ECO:0000269|PubMed:25385819, ECO:0000269|PubMed:25825441, ECO:0000269|PubMed:30883606}.; FUNCTION: [Isoform 2]: Proposed to inhibit LPS-TLR4 signaling at the late endosome by interaction with isoform 1 thereby disrupting the association of isoform 1 with TICAM1. May be involved in TLR4 degradation in late endosomes. |
| Q8IUW3 | SPATA2L | S317 | ochoa | Spermatogenesis-associated protein 2-like protein (SPATA2-like protein) | None |
| Q8IVE3 | PLEKHH2 | S202 | ochoa | Pleckstrin homology domain-containing family H member 2 | In the kidney glomerulus may play a role in linking podocyte foot processes to the glomerular basement membrane. May be involved in stabilization of F-actin by attenuating its depolymerization. Can recruit TGFB1I1 from focal adhesions to podocyte lamellipodia. |
| Q8IVL1 | NAV2 | S1877 | ochoa | Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2) | Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs. {ECO:0000269|PubMed:12214280, ECO:0000269|PubMed:15158073}. |
| Q8IVL1 | NAV2 | S1970 | ochoa | Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2) | Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs. {ECO:0000269|PubMed:12214280, ECO:0000269|PubMed:15158073}. |
| Q8IWU2 | LMTK2 | S1450 | ochoa|psp | Serine/threonine-protein kinase LMTK2 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase 2) (Brain-enriched kinase) (hBREK) (CDK5/p35-regulated kinase) (CPRK) (Kinase/phosphatase/inhibitor 2) (Lemur tyrosine kinase 2) (Serine/threonine-protein kinase KPI-2) | Phosphorylates PPP1C, phosphorylase b and CFTR. |
| Q8IWX8 | CHERP | S186 | ochoa | Calcium homeostasis endoplasmic reticulum protein (ERPROT 213-21) (SR-related CTD-associated factor 6) | Involved in calcium homeostasis, growth and proliferation. {ECO:0000269|PubMed:10794731, ECO:0000269|PubMed:12656674}. |
| Q8IYD8 | FANCM | S948 | ochoa | Fanconi anemia group M protein (Protein FACM) (EC 3.6.4.13) (ATP-dependent RNA helicase FANCM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog) | DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (PubMed:16116422). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:16116422, PubMed:19423727, PubMed:20347428, PubMed:20347429, PubMed:29231814). In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (PubMed:20347428, PubMed:20347429). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX (PubMed:20347429). In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates (PubMed:17289582). In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA (PubMed:16116434). {ECO:0000269|PubMed:16116422, ECO:0000269|PubMed:16116434, ECO:0000269|PubMed:17289582, ECO:0000269|PubMed:19423727, ECO:0000269|PubMed:20347428, ECO:0000269|PubMed:20347429, ECO:0000269|PubMed:29231814}. |
| Q8IZQ1 | WDFY3 | S984 | ochoa | WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy) | Required for selective macroautophagy (aggrephagy). Acts as an adapter protein by linking specific proteins destined for degradation to the core autophagic machinery members, such as the ATG5-ATG12-ATG16L E3-like ligase, SQSTM1 and LC3 (PubMed:20417604). Along with p62/SQSTM1, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with SQSTM1, required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Important for normal brain development. Essential for the formation of axonal tracts throughout the brain and spinal cord, including the formation of the major forebrain commissures. Involved in the ability of neural cells to respond to guidance cues. Required for cortical neurons to respond to the trophic effects of netrin-1/NTN1 (By similarity). Regulates Wnt signaling through the removal of DVL3 aggregates, likely in an autophagy-dependent manner. This process may be important for the determination of brain size during embryonic development (PubMed:27008544). May regulate osteoclastogenesis by acting on the TNFSF11/RANKL - TRAF6 pathway (By similarity). After cytokinetic abscission, involved in midbody remnant degradation (PubMed:24128730). In vitro strongly binds to phosphatidylinositol 3-phosphate (PtdIns3P) (PubMed:15292400). {ECO:0000250|UniProtKB:Q6VNB8, ECO:0000269|PubMed:15292400, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20417604, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:27008544}. |
| Q8N122 | RPTOR | S792 | psp | Regulatory-associated protein of mTOR (Raptor) (p150 target of rapamycin (TOR)-scaffold protein) | Component of the mechanistic target of rapamycin complex 1 (mTORC1), an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:26588989, PubMed:32561715, PubMed:37541260). In response to nutrients, growth factors or amino acids, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating several substrates, such as ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:26588989, PubMed:37541260). In the same time, it inhibits catabolic pathways by phosphorylating the autophagy initiation components ULK1 and ATG13, as well as transcription factor TFEB, a master regulators of lysosomal biogenesis and autophagy (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:32561715, PubMed:37541260). The mTORC1 complex is inhibited in response to starvation and amino acid depletion (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:37541260). Within the mTORC1 complex, RPTOR acts both as a molecular adapter, which (1) mediates recruitment of mTORC1 to lysosomal membranes via interaction with small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD), and a (2) substrate-specific adapter, which promotes substrate specificity by binding to TOS motif-containing proteins and direct them towards the active site of the MTOR kinase domain for phosphorylation (PubMed:12747827, PubMed:24403073, PubMed:26588989, PubMed:37541260). mTORC1 complex regulates many cellular processes, such as odontoblast and osteoclast differentiation or neuronal transmission (By similarity). mTORC1 complex in excitatory neuronal transmission is required for the prosocial behavior induced by the psychoactive substance lysergic acid diethylamide (LSD) (By similarity). {ECO:0000250|UniProtKB:Q8K4Q0, ECO:0000269|PubMed:12150925, ECO:0000269|PubMed:12150926, ECO:0000269|PubMed:12747827, ECO:0000269|PubMed:24403073, ECO:0000269|PubMed:26588989, ECO:0000269|PubMed:32561715, ECO:0000269|PubMed:37541260}. |
| Q8N264 | ARHGAP24 | S391 | ochoa|psp | Rho GTPase-activating protein 24 (Filamin-A-associated RhoGAP) (FilGAP) (RAC1- and CDC42-specific GTPase-activating protein of 72 kDa) (RC-GAP72) (Rho-type GTPase-activating protein 24) (RhoGAP of 73 kDa) (Sarcoma antigen NY-SAR-88) (p73RhoGAP) | Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis. {ECO:0000269|PubMed:15302923, ECO:0000269|PubMed:15611138, ECO:0000269|PubMed:16862148}. |
| Q8N3X1 | FNBP4 | S784 | ochoa | Formin-binding protein 4 (Formin-binding protein 30) | None |
| Q8N3X6 | LCORL | S485 | ochoa | Ligand-dependent nuclear receptor corepressor-like protein (LCoR-like protein) | May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. May play a role in spermatogenesis (By similarity). {ECO:0000250}. |
| Q8N8S7 | ENAH | S125 | ochoa | Protein enabled homolog | Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation (By similarity). {ECO:0000250, ECO:0000269|PubMed:11696321, ECO:0000269|PubMed:18158903}. |
| Q8NEB9 | PIK3C3 | S455 | ochoa | Phosphatidylinositol 3-kinase catalytic subunit type 3 (PI3-kinase type 3) (PI3K type 3) (PtdIns-3-kinase type 3) (EC 2.7.1.137) (Phosphatidylinositol 3-kinase p100 subunit) (Phosphoinositide-3-kinase class 3) (hVps34) | Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (PubMed:14617358, PubMed:33637724, PubMed:7628435). As part of PI3KC3-C1, promotes endoplasmic reticulum membrane curvature formation prior to vesicle budding (PubMed:32690950). Involved in regulation of degradative endocytic trafficking and required for the abscission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20208530, PubMed:20643123). Involved in the transport of lysosomal enzyme precursors to lysosomes (By similarity). Required for transport from early to late endosomes (By similarity). {ECO:0000250|UniProtKB:O88763, ECO:0000269|PubMed:14617358, ECO:0000269|PubMed:20208530, ECO:0000269|PubMed:20643123, ECO:0000269|PubMed:32690950, ECO:0000269|PubMed:33637724, ECO:0000269|PubMed:7628435}.; FUNCTION: (Microbial infection) Kinase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
| Q8NER1 | TRPV1 | S117 | psp | Transient receptor potential cation channel subfamily V member 1 (TrpV1) (Capsaicin receptor) (Osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1) | Non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli (PubMed:11050376, PubMed:11243859, PubMed:11226139, PubMed:12077606). Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activated by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius (PubMed:37117175). Upon activation, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis. {ECO:0000250|UniProtKB:O35433, ECO:0000269|PubMed:11050376, ECO:0000269|PubMed:11226139, ECO:0000269|PubMed:11243859, ECO:0000269|PubMed:12077606, ECO:0000269|PubMed:37117175}. |
| Q8NEV8 | EXPH5 | S688 | ochoa | Exophilin-5 (Synaptotagmin-like protein homolog lacking C2 domains b) (SlaC2-b) (Slp homolog lacking C2 domains b) | May act as Rab effector protein and play a role in vesicle trafficking. |
| Q8NH09 | OR8S1 | S285 | ochoa | Olfactory receptor 8S1 | Odorant receptor. {ECO:0000305}. |
| Q8TD26 | CHD6 | S1840 | ochoa | Chromodomain-helicase-DNA-binding protein 6 (CHD-6) (EC 3.6.4.-) (ATP-dependent helicase CHD6) (Radiation-induced gene B protein) | ATP-dependent chromatin-remodeling factor (PubMed:17027977, PubMed:28533432). Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin; nucleosome disruption requires ATP (PubMed:28533432). Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2. {ECO:0000269|PubMed:16314513, ECO:0000269|PubMed:17027977, ECO:0000269|PubMed:28533432}.; FUNCTION: (Microbial infection) Acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. {ECO:0000269|PubMed:20631145, ECO:0000269|PubMed:21899694, ECO:0000269|PubMed:23408615}. |
| Q8TDW5 | SYTL5 | S396 | ochoa | Synaptotagmin-like protein 5 | May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids. |
| Q8TF72 | SHROOM3 | S582 | ochoa | Protein Shroom3 (Shroom-related protein) (hShrmL) | Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}. |
| Q8TF76 | HASPIN | S430 | psp | Serine/threonine-protein kinase haspin (EC 2.7.11.1) (Germ cell-specific gene 2 protein) (H-haspin) (Haploid germ cell-specific nuclear protein kinase) | Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle. {ECO:0000269|PubMed:11228240, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:17084365, ECO:0000269|PubMed:20705812, ECO:0000269|PubMed:20929775}. |
| Q8WUM0 | NUP133 | S594 | ochoa | Nuclear pore complex protein Nup133 (133 kDa nucleoporin) (Nucleoporin Nup133) | Involved in poly(A)+ RNA transport. Involved in nephrogenesis (PubMed:30179222). {ECO:0000269|PubMed:11684705, ECO:0000269|PubMed:30179222}. |
| Q8WUY3 | PRUNE2 | S2023 | ochoa | Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1) | May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. {ECO:0000269|PubMed:16288218}. |
| Q8WVF1 | OSCP1 | S274 | ochoa | Protein OSCP1 (hOSCP1) (Organic solute transport protein 1) (Oxidored-nitro domain-containing protein 1) | May be involved in drug clearance in the placenta. {ECO:0000269|PubMed:16006562}. |
| Q8WXI7 | MUC16 | S5042 | ochoa | Mucin-16 (MUC-16) (Ovarian cancer-related tumor marker CA125) (CA-125) (Ovarian carcinoma antigen CA125) | Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. {ECO:0000250}. |
| Q8WXI7 | MUC16 | S6969 | ochoa | Mucin-16 (MUC-16) (Ovarian cancer-related tumor marker CA125) (CA-125) (Ovarian carcinoma antigen CA125) | Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. {ECO:0000250}. |
| Q92545 | TMEM131 | S1515 | ochoa | Transmembrane protein 131 (Protein RW1) | Collagen binding transmembrane protein involved in collagen secretion by recruiting the ER-to-Golgi transport complex TRAPPIII (PubMed:32095531). May play a role in the immune response to viral infection. {ECO:0000250, ECO:0000269|PubMed:32095531}. |
| Q92575 | UBXN4 | S132 | ochoa | UBX domain-containing protein 4 (Erasin) (UBX domain-containing protein 2) | Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD (PubMed:19822669). {ECO:0000269|PubMed:16968747, ECO:0000269|PubMed:19822669}. |
| Q92613 | JADE3 | S612 | ochoa | Protein Jade-3 (Jade family PHD finger protein 3) (PHD finger protein 16) | Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity. {ECO:0000269|PubMed:16387653}. |
| Q92681 | RSC1A1 | S493 | ochoa | Regulatory solute carrier protein family 1 member 1 (Transporter regulator RS1) (hRS1) | Mediates transcriptional and post-transcriptional regulation of SLC5A1. Inhibits a dynamin and PKC-dependent exocytotic pathway of SLC5A1. Also involved in transcriptional regulation of SLC22A2. Exhibits glucose-dependent, short-term inhibition of SLC5A1 and SLC22A2 by inhibiting the release of vesicles from the trans-Golgi network. {ECO:0000269|PubMed:14724758, ECO:0000269|PubMed:16788146, ECO:0000269|PubMed:8836035}. |
| Q96AY4 | TTC28 | S2224 | ochoa | Tetratricopeptide repeat protein 28 (TPR repeat protein 28) (TPR repeat-containing big gene cloned at Keio) | During mitosis, may be involved in the condensation of spindle midzone microtubules, leading to the formation of midbody. {ECO:0000269|PubMed:23036704}. |
| Q96CN9 | GCC1 | S620 | ochoa | GRIP and coiled-coil domain-containing protein 1 (Golgi coiled-coil protein 1) | Probably involved in maintaining Golgi structure. |
| Q96DR7 | ARHGEF26 | S22 | ochoa | Rho guanine nucleotide exchange factor 26 (SH3 domain-containing guanine exchange factor) | Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry. {ECO:0000269|PubMed:15133129, ECO:0000269|PubMed:17074883, ECO:0000269|PubMed:17875742}. |
| Q96DX4 | RSPRY1 | S55 | ochoa | RING finger and SPRY domain-containing protein 1 | None |
| Q96DX8 | RTP4 | S186 | ochoa | Receptor-transporting protein 4 (28 kDa interferon-responsive protein) (3CxxC-type zinc finger protein 4) | Chaperone protein that facilitates the trafficking and functional cell surface expression of some G-protein coupled receptors (GPCRs) (PubMed:18836069). Promotes functional expression of the bitter taste receptor TAS2R16 (PubMed:16720576). Also promotes functional expression of the opioid receptor heterodimer OPRD1-OPRM1 (By similarity). In addition, acts as a potent IFN-inducible suppressor of pathogens including lyssavirus rabies, influenza A or yellow fever virus (PubMed:33113352). Mechanistically, associates with the viral replicase, binds viral RNA, and thereby suppresses viral genome amplification that replicates at the endoplasmic reticulum (By similarity). In addition, restores antiviral signaling by interacting with and sequestering influenza A virus protein NS1 (PubMed:39798334). {ECO:0000250|UniProtKB:Q9ER80, ECO:0000269|PubMed:16720576, ECO:0000269|PubMed:18836069, ECO:0000269|PubMed:33113352, ECO:0000269|PubMed:39798334}. |
| Q96EQ0 | SGTB | S77 | ochoa | Small glutamine-rich tetratricopeptide repeat-containing protein beta (Beta-SGT) (Small glutamine-rich protein with tetratricopeptide repeats 2) | Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity. {ECO:0000250}. |
| Q96F07 | CYFIP2 | S927 | ochoa | Cytoplasmic FMR1-interacting protein 2 (p53-inducible protein 121) | Involved in T-cell adhesion and p53/TP53-dependent induction of apoptosis. Does not bind RNA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). {ECO:0000250|UniProtKB:Q5SQX6, ECO:0000269|PubMed:10449408, ECO:0000269|PubMed:15048733, ECO:0000269|PubMed:17245118}. |
| Q96GX5 | MASTL | S217 | ochoa | Serine/threonine-protein kinase greatwall (GW) (GWL) (hGWL) (EC 2.7.11.1) (Microtubule-associated serine/threonine-protein kinase-like) (MAST-L) | Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance (PubMed:19680222). Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively (PubMed:38123684). ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high (PubMed:20818157). Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation. {ECO:0000269|PubMed:12890928, ECO:0000269|PubMed:19680222, ECO:0000269|PubMed:19793917, ECO:0000269|PubMed:20538976, ECO:0000269|PubMed:20818157, ECO:0000269|PubMed:38123684}. |
| Q96GX5 | MASTL | S277 | ochoa | Serine/threonine-protein kinase greatwall (GW) (GWL) (hGWL) (EC 2.7.11.1) (Microtubule-associated serine/threonine-protein kinase-like) (MAST-L) | Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance (PubMed:19680222). Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively (PubMed:38123684). ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high (PubMed:20818157). Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation. {ECO:0000269|PubMed:12890928, ECO:0000269|PubMed:19680222, ECO:0000269|PubMed:19793917, ECO:0000269|PubMed:20538976, ECO:0000269|PubMed:20818157, ECO:0000269|PubMed:38123684}. |
| Q96GX5 | MASTL | S660 | ochoa | Serine/threonine-protein kinase greatwall (GW) (GWL) (hGWL) (EC 2.7.11.1) (Microtubule-associated serine/threonine-protein kinase-like) (MAST-L) | Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance (PubMed:19680222). Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively (PubMed:38123684). ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high (PubMed:20818157). Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation. {ECO:0000269|PubMed:12890928, ECO:0000269|PubMed:19680222, ECO:0000269|PubMed:19793917, ECO:0000269|PubMed:20538976, ECO:0000269|PubMed:20818157, ECO:0000269|PubMed:38123684}. |
| Q96JA1 | LRIG1 | S1033 | ochoa | Leucine-rich repeats and immunoglobulin-like domains protein 1 (LIG-1) | Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation. {ECO:0000269|PubMed:15282549}. |
| Q96JQ2 | CLMN | S526 | ochoa | Calmin (Calponin-like transmembrane domain protein) | None |
| Q96RL1 | UIMC1 | S139 | ochoa | BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Retinoid X receptor-interacting protein 110) (Ubiquitin interaction motif-containing protein 1) | Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.38). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. {ECO:0000269|PubMed:12080054, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:17525342, ECO:0000269|PubMed:17621610, ECO:0000269|PubMed:17643121, ECO:0000269|PubMed:19015238, ECO:0000269|PubMed:19202061, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19328070, ECO:0000269|PubMed:24627472, ECO:0000269|Ref.38}. |
| Q96RY5 | CRAMP1 | S765 | ochoa | Protein cramped-like (Cramped chromatin regulator homolog 1) (Hematological and neurological expressed 1-like protein) | None |
| Q96SB4 | SRPK1 | S408 | psp | SRSF protein kinase 1 (EC 2.7.11.1) (SFRS protein kinase 1) (Serine/arginine-rich protein-specific kinase 1) (SR-protein-specific kinase 1) | Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activities, such as chromatin reorganization in somatic and sperm cells and cell cycle progression. Isoform 2 phosphorylates SFRS2, ZRSR2, LBR and PRM1. Isoform 2 phosphorylates SRSF1 using a directional (C-terminal to N-terminal) and a dual-track mechanism incorporating both processive phosphorylation (in which the kinase stays attached to the substrate after each round of phosphorylation) and distributive phosphorylation steps (in which the kinase and substrate dissociate after each phosphorylation event). The RS domain of SRSF1 binds first to a docking groove in the large lobe of the kinase domain of SRPK1. This induces certain structural changes in SRPK1 and/or RRM2 domain of SRSF1, allowing RRM2 to bind the kinase and initiate phosphorylation. The cycles continue for several phosphorylation steps in a processive manner (steps 1-8) until the last few phosphorylation steps (approximately steps 9-12). During that time, a mechanical stress induces the unfolding of the beta-4 motif in RRM2, which then docks at the docking groove of SRPK1. This also signals RRM2 to begin to dissociate, which facilitates SRSF1 dissociation after phosphorylation is completed. Isoform 2 can mediate hepatitis B virus (HBV) core protein phosphorylation. It plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles. Isoform 1 and isoform 2 can induce splicing of exon 10 in MAPT/TAU. The ratio of isoform 1/isoform 2 plays a decisive role in determining cell fate in K-562 leukaemic cell line: isoform 2 favors proliferation where as isoform 1 favors differentiation. {ECO:0000269|PubMed:10049757, ECO:0000269|PubMed:10390541, ECO:0000269|PubMed:11509566, ECO:0000269|PubMed:12134018, ECO:0000269|PubMed:14555757, ECO:0000269|PubMed:15034300, ECO:0000269|PubMed:16122776, ECO:0000269|PubMed:16209947, ECO:0000269|PubMed:18155240, ECO:0000269|PubMed:18687337, ECO:0000269|PubMed:19240134, ECO:0000269|PubMed:19477182, ECO:0000269|PubMed:19886675, ECO:0000269|PubMed:20708644, ECO:0000269|PubMed:8208298, ECO:0000269|PubMed:9237760}. |
| Q96T58 | SPEN | S1354 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q99640 | PKMYT1 | S441 | psp | Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase) | Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins (PubMed:10373560, PubMed:10504341, PubMed:9001210, PubMed:9268380). Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation (PubMed:9001210, PubMed:9268380). May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect (PubMed:9001210, PubMed:9268380). {ECO:0000269|PubMed:10373560, ECO:0000269|PubMed:10504341, ECO:0000269|PubMed:9001210, ECO:0000269|PubMed:9268380}. |
| Q9BSJ8 | ESYT1 | S860 | ochoa | Extended synaptotagmin-1 (E-Syt1) (Membrane-bound C2 domain-containing protein) | Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels (PubMed:23791178, PubMed:24183667). Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane (PubMed:24183667). Acts as an inhibitor of ADGRD1 G-protein-coupled receptor activity in absence of cytosolic calcium (PubMed:38758649). Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). {ECO:0000250|UniProtKB:A0FGR8, ECO:0000269|PubMed:23791178, ECO:0000269|PubMed:24183667, ECO:0000269|PubMed:38758649}. |
| Q9BVV7 | TIMM21 | S151 | ochoa | Mitochondrial import inner membrane translocase subunit Tim21 (TIM21-like protein, mitochondrial) | Participates in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex. Probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes. {ECO:0000269|PubMed:23260140}. |
| Q9BYI3 | HYCC1 | S372 | ochoa | Hyccin (Down-regulated by CTNNB1 protein A) | Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (PubMed:26571211). HYCC1 plays a key role in oligodendrocytes formation, a cell type with expanded plasma membrane that requires generation of PtdIns(4)P (PubMed:26571211). Its role in oligodendrocytes formation probably explains its importance in myelination of the central and peripheral nervous system (PubMed:16951682, PubMed:26571211). May also have a role in the beta-catenin/Lef signaling pathway (Probable). {ECO:0000269|PubMed:16951682, ECO:0000269|PubMed:26571211, ECO:0000305|PubMed:10910037}. |
| Q9BYV8 | CEP41 | S344 | ochoa | Centrosomal protein of 41 kDa (Cep41) (Testis-specific gene A14 protein) | Required during ciliogenesis for tubulin glutamylation in cilium. Probably acts by participating in the transport of TTLL6, a tubulin polyglutamylase, between the basal body and the cilium. {ECO:0000269|PubMed:22246503}. |
| Q9BYW2 | SETD2 | S344 | ochoa | Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) | Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}. |
| Q9C0C2 | TNKS1BP1 | S1103 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9C0K7 | STRADB | S304 | ochoa | STE20-related kinase adapter protein beta (STRAD beta) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein) (CALS-21) (ILP-interacting protein) (Pseudokinase ALS2CR2) | Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (By similarity). {ECO:0000250, ECO:0000269|PubMed:14517248}. |
| Q9H089 | LSG1 | S413 | ochoa | Large subunit GTPase 1 homolog (hLsg1) (EC 3.6.5.-) | Functions as a GTPase (PubMed:16209721). May act by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm during the 60S ribosomal subunit maturation (PubMed:31148378). {ECO:0000269|PubMed:16209721, ECO:0000269|PubMed:31148378}. |
| Q9H1A4 | ANAPC1 | S733 | ochoa | Anaphase-promoting complex subunit 1 (APC1) (Cyclosome subunit 1) (Mitotic checkpoint regulator) (Testis-specific gene 24 protein) | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
| Q9H1H9 | KIF13A | S1632 | ochoa | Kinesin-like protein KIF13A (Kinesin-like protein RBKIN) | Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR-containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abscission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis. {ECO:0000269|PubMed:19841138, ECO:0000269|PubMed:20208530}. |
| Q9H4A3 | WNK1 | S1220 | ochoa | Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1) | Serine/threonine-protein kinase component of the WNK1-SPAK/OSR1 kinase cascade, which acts as a key regulator of blood pressure and regulatory volume increase by promoting ion influx (PubMed:15883153, PubMed:17190791, PubMed:31656913, PubMed:34289367, PubMed:36318922). WNK1 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK1 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK1-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:15883153, PubMed:16263722, PubMed:17190791, PubMed:19739668, PubMed:21321328, PubMed:22989884, PubMed:25477473, PubMed:34289367, PubMed:36318922). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A5/KCC2 and SLC12A6/KCC3, regulating their activity (PubMed:16263722, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:19665974, PubMed:21321328). Also acts as a regulator of angiogenesis in endothelial cells via activation of OXSR1/OSR1 and STK39/SPAK: activation of OXSR1/OSR1 regulates chemotaxis and invasion, while STK39/SPAK regulates endothelial cell proliferation (PubMed:25362046). Also acts independently of the WNK1-SPAK/OSR1 kinase cascade by catalyzing phosphorylation of other substrates, such as SYT2, PCF11 and NEDD4L (PubMed:29196535). Mediates phosphorylation of SYT2, regulating SYT2 association with phospholipids and membrane-binding (By similarity). Regulates mRNA export in the nucleus by mediating phosphorylation of PCF11, thereby decreasing the association between PCF11 and POLR2A/RNA polymerase II and promoting mRNA export to the cytoplasm (PubMed:29196535). Acts as a negative regulator of autophagy (PubMed:27911840). Required for the abscission step during mitosis, independently of the WNK1-SPAK/OSR1 kinase cascade (PubMed:21220314). May also play a role in actin cytoskeletal reorganization (PubMed:10660600). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as SLC4A4, SLC26A6, SLC26A9, TRPV4 and CFTR (By similarity). Involved in the regulation of epithelial Na(+) channel (ENaC) by promoting activation of SGK1 in a kinase-independent manner: probably acts as a scaffold protein that promotes the recruitment of SGK1 to the mTORC2 complex in response to chloride, leading to mTORC2-dependent phosphorylation and activation of SGK1 (PubMed:36373794). Acts as an assembly factor for the ER membrane protein complex independently of its protein kinase activity: associates with EMC2 in the cytoplasm via its amphipathic alpha-helix, and prevents EMC2 ubiquitination and subsequent degradation, thereby promoting EMC2 stabilization (PubMed:33964204). {ECO:0000250|UniProtKB:P83741, ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:15883153, ECO:0000269|PubMed:16263722, ECO:0000269|PubMed:17190791, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:19739668, ECO:0000269|PubMed:21220314, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:25477473, ECO:0000269|PubMed:27911840, ECO:0000269|PubMed:29196535, ECO:0000269|PubMed:31656913, ECO:0000269|PubMed:33964204, ECO:0000269|PubMed:34289367, ECO:0000269|PubMed:36318922, ECO:0000269|PubMed:36373794}.; FUNCTION: [Isoform 3]: Kinase-defective isoform specifically expressed in kidney, which acts as a dominant-negative regulator of the longer isoform 1 (PubMed:14645531). Does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport (By similarity). Down-regulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity (By similarity). In kidney, may play an important role regulating sodium and potassium balance (By similarity). {ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:14645531}. |
| Q9HD67 | MYO10 | S1143 | ochoa | Unconventional myosin-X (Unconventional myosin-10) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as a plus end-directed motor. Moves with higher velocity and takes larger steps on actin bundles than on single actin filaments (PubMed:27580874). The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation. Plays a role in formation of the podosome belt in osteoclasts. {ECO:0000269|PubMed:16894163, ECO:0000269|PubMed:18570893, ECO:0000269|PubMed:27580874}.; FUNCTION: [Isoform Headless]: Functions as a dominant-negative regulator of isoform 1, suppressing its filopodia-inducing and axon outgrowth-promoting activities. In hippocampal neurons, it increases VASP retention in spine heads to induce spine formation and spine head expansion (By similarity). {ECO:0000250|UniProtKB:F8VQB6}. |
| Q9NP66 | HMG20A | S20 | ochoa | High mobility group protein 20A (HMG box-containing protein 20A) (HMG domain-containing protein 1) (HMG domain-containing protein HMGX1) | Plays a role in neuronal differentiation as chromatin-associated protein. Acts as inhibitor of HMG20B. Overcomes the repressive effects of the neuronal silencer REST and induces the activation of neuronal-specific genes. Involved in the recruitment of the histone methyltransferase KMT2A/MLL1 and consequent increased methylation of histone H3 lysine 4 (By similarity). {ECO:0000250}. |
| Q9NP71 | MLXIPL | S631 | ochoa | Carbohydrate-responsive element-binding protein (ChREBP) (Class D basic helix-loop-helix protein 14) (bHLHd14) (MLX interactor) (MLX-interacting protein-like) (WS basic-helix-loop-helix leucine zipper protein) (WS-bHLH) (Williams-Beuren syndrome chromosomal region 14 protein) | Binds DNA as a heterodimer with MLX/TCFL4 and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation (By similarity). Regulates transcription in response to changes in cellular carbohydrate abundance such as occurs during fasting to feeding metabolic transition. Refeeding stimulates MLXIPL/ChREBP transcription factor, leading to increased BCKDK to PPM1K expression ratio, phosphorylation and activation of ACLY that ultimately results in the generation of malonyl-CoA and oxaloacetate immediate substrates of de novo lipogenesis and gluconeogenesis, respectively (By similarity). {ECO:0000250|UniProtKB:Q2VPU4, ECO:0000250|UniProtKB:Q9HAP2}. |
| Q9NR48 | ASH1L | S179 | ochoa | Histone-lysine N-methyltransferase ASH1L (EC 2.1.1.359) (EC 2.1.1.367) (ASH1-like protein) (huASH1) (Absent small and homeotic disks protein 1 homolog) (Lysine N-methyltransferase 2H) | Histone methyltransferase specifically trimethylating 'Lys-36' of histone H3 forming H3K36me3 (PubMed:21239497). Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). The physiological significance of the H3K9me1 activity is unclear (By similarity). {ECO:0000250|UniProtKB:Q99MY8, ECO:0000269|PubMed:21239497}. |
| Q9NRL2 | BAZ1A | S956 | ochoa | Bromodomain adjacent to zinc finger domain protein 1A (ATP-dependent chromatin-remodeling protein) (ATP-utilizing chromatin assembly and remodeling factor 1) (hACF1) (CHRAC subunit ACF1) (Williams syndrome transcription factor-related chromatin-remodeling factor 180) (WCRF180) (hWALp1) | Regulatory subunit of the ATP-dependent ACF-1 and ACF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and slide edge- and center-positioned histone octamers away from their original location on the DNA template to facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:17099699, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:14759371, PubMed:17099699, PubMed:28801535). The ACF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the ACF-5 ISWI chromatin remodeling complex (PubMed:28801535). Has a role in sensing the length of DNA which flank nucleosomes, which modulates the nucleosome spacing activity of the ACF-5 ISWI chromatin remodeling complex (PubMed:17099699). Involved in DNA replication and together with SMARCA5/SNF2H is required for replication of pericentric heterochromatin in S-phase (PubMed:12434153). May have a role in nuclear receptor-mediated transcription repression (PubMed:17519354). {ECO:0000269|PubMed:12434153, ECO:0000269|PubMed:14759371, ECO:0000269|PubMed:17099699, ECO:0000269|PubMed:17519354, ECO:0000269|PubMed:28801535}. |
| Q9NRL2 | BAZ1A | S1320 | ochoa | Bromodomain adjacent to zinc finger domain protein 1A (ATP-dependent chromatin-remodeling protein) (ATP-utilizing chromatin assembly and remodeling factor 1) (hACF1) (CHRAC subunit ACF1) (Williams syndrome transcription factor-related chromatin-remodeling factor 180) (WCRF180) (hWALp1) | Regulatory subunit of the ATP-dependent ACF-1 and ACF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and slide edge- and center-positioned histone octamers away from their original location on the DNA template to facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:17099699, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:14759371, PubMed:17099699, PubMed:28801535). The ACF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the ACF-5 ISWI chromatin remodeling complex (PubMed:28801535). Has a role in sensing the length of DNA which flank nucleosomes, which modulates the nucleosome spacing activity of the ACF-5 ISWI chromatin remodeling complex (PubMed:17099699). Involved in DNA replication and together with SMARCA5/SNF2H is required for replication of pericentric heterochromatin in S-phase (PubMed:12434153). May have a role in nuclear receptor-mediated transcription repression (PubMed:17519354). {ECO:0000269|PubMed:12434153, ECO:0000269|PubMed:14759371, ECO:0000269|PubMed:17099699, ECO:0000269|PubMed:17519354, ECO:0000269|PubMed:28801535}. |
| Q9NVE5 | USP40 | S414 | ochoa | Ubiquitin carboxyl-terminal hydrolase 40 (EC 3.4.19.12) (Deubiquitinating enzyme 40) (Ubiquitin thioesterase 40) (Ubiquitin-specific-processing protease 40) | May be catalytically inactive. |
| Q9NWQ8 | PAG1 | S50 | ochoa | Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Csk-binding protein) (Transmembrane adapter protein PAG) (Transmembrane phosphoprotein Cbp) | Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling. {ECO:0000269|PubMed:10790433}. |
| Q9NXL6 | SIDT1 | S362 | ochoa | SID1 transmembrane family member 1 | In vitro binds long double-stranded RNA (dsRNA) (500 and 700 base pairs), but not dsRNA shorter than 300 bp. Not involved in RNA autophagy, a process in which RNA is directly imported into lysosomes in an ATP-dependent manner, and degraded. {ECO:0000250|UniProtKB:Q6AXF6}. |
| Q9NY27 | PPP4R2 | S364 | ochoa | Serine/threonine-protein phosphatase 4 regulatory subunit 2 | Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair. {ECO:0000269|PubMed:10769191, ECO:0000269|PubMed:12668731, ECO:0000269|PubMed:18614045, ECO:0000269|PubMed:20154705}. |
| Q9P2F8 | SIPA1L2 | S1461 | ochoa | Signal-induced proliferation-associated 1-like protein 2 (SIPA1-like protein 2) | None |
| Q9UBT7 | CTNNAL1 | S374 | ochoa | Alpha-catulin (Alpha-catenin-related protein) (ACRP) (Catenin alpha-like protein 1) | May modulate the Rho pathway signaling by providing a scaffold for the Lbc Rho guanine nucleotide exchange factor (ARHGEF1). |
| Q9UGP4 | LIMD1 | S172 | ochoa | LIM domain-containing protein 1 | Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation. {ECO:0000269|PubMed:15542589, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22286099}. |
| Q9UH92 | MLX | S98 | ochoa | Max-like protein X (Class D basic helix-loop-helix protein 13) (bHLHd13) (Max-like bHLHZip protein) (Protein BigMax) (Transcription factor-like protein 4) | Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MAD1, MAD4, MNT, WBSCR14 and MLXIP which recognizes the core sequence 5'-CACGTG-3'. The TCFL4-MAD1, TCFL4-MAD4, TCFL4-WBSCR14 complexes are transcriptional repressors. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation. {ECO:0000269|PubMed:10593926, ECO:0000269|PubMed:12446771, ECO:0000269|PubMed:16782875}. |
| Q9UHD2 | TBK1 | S511 | ochoa | Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1) | Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents (PubMed:10581243, PubMed:11839743, PubMed:12692549, PubMed:12702806, PubMed:14703513, PubMed:15367631, PubMed:15485837, PubMed:18583960, PubMed:21138416, PubMed:23453971, PubMed:23453972, PubMed:23746807, PubMed:25636800, PubMed:26611359, PubMed:32404352, PubMed:34363755, PubMed:32298923). Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X (PubMed:12692549, PubMed:12702806, PubMed:14703513, PubMed:15367631, PubMed:18583960, PubMed:25636800). This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB (PubMed:12702806, PubMed:15367631, PubMed:25636800, PubMed:32972995). In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli (PubMed:23453971, PubMed:23453972, PubMed:23746807). Plays a key role in IRF3 activation: acts by first phosphorylating innate adapter proteins MAVS, STING1 and TICAM1 on their pLxIS motif, leading to recruitment of IRF3, thereby licensing IRF3 for phosphorylation by TBK1 (PubMed:25636800, PubMed:30842653, PubMed:37926288). Phosphorylated IRF3 dissociates from the adapter proteins, dimerizes, and then enters the nucleus to induce expression of interferons (PubMed:25636800). Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes (PubMed:21931631). Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus (PubMed:10783893, PubMed:15489227). Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterial autophagy (PubMed:21617041). Phosphorylates SMCR8 component of the C9orf72-SMCR8 complex, promoting autophagosome maturation (PubMed:27103069). Phosphorylates ATG8 proteins MAP1LC3C and GABARAPL2, thereby preventing their delipidation and premature removal from nascent autophagosomes (PubMed:31709703). Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, which leads to a negative impact on insulin sensitivity (By similarity). Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C (PubMed:21270402). Phosphorylates Borna disease virus (BDV) P protein (PubMed:16155125). Plays an essential role in the TLR3- and IFN-dependent control of herpes virus HSV-1 and HSV-2 infections in the central nervous system (PubMed:22851595). Acts both as a positive and negative regulator of the mTORC1 complex, depending on the context: activates mTORC1 in response to growth factors by catalyzing phosphorylation of MTOR, while it limits the mTORC1 complex by promoting phosphorylation of RPTOR (PubMed:29150432, PubMed:31530866). Acts as a positive regulator of the mTORC2 complex by mediating phosphorylation of MTOR, leading to increased phosphorylation and activation of AKT1 (By similarity). Phosphorylates and activates AKT1 (PubMed:21464307). Involved in the regulation of TNF-induced RIPK1-mediated cell death, probably acting via CYLD phosphorylation that in turn controls RIPK1 ubiquitination status (PubMed:34363755). Also participates in the differentiation of T follicular regulatory cells together with the receptor ICOS (PubMed:27135603). {ECO:0000250|UniProtKB:Q9WUN2, ECO:0000269|PubMed:10581243, ECO:0000269|PubMed:10783893, ECO:0000269|PubMed:11839743, ECO:0000269|PubMed:12692549, ECO:0000269|PubMed:12702806, ECO:0000269|PubMed:14703513, ECO:0000269|PubMed:15367631, ECO:0000269|PubMed:15485837, ECO:0000269|PubMed:15489227, ECO:0000269|PubMed:16155125, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:21270402, ECO:0000269|PubMed:21464307, ECO:0000269|PubMed:21617041, ECO:0000269|PubMed:21931631, ECO:0000269|PubMed:22851595, ECO:0000269|PubMed:23453971, ECO:0000269|PubMed:23453972, ECO:0000269|PubMed:23746807, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:26611359, ECO:0000269|PubMed:27103069, ECO:0000269|PubMed:27135603, ECO:0000269|PubMed:29150432, ECO:0000269|PubMed:30842653, ECO:0000269|PubMed:31530866, ECO:0000269|PubMed:31709703, ECO:0000269|PubMed:32298923, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:34363755, ECO:0000269|PubMed:37926288}. |
| Q9UHG0 | DCDC2 | S240 | ochoa | Doublecortin domain-containing protein 2 (Protein RU2S) | Protein that plays a role in the inhibition of canonical Wnt signaling pathway (PubMed:25557784). May be involved in neuronal migration during development of the cerebral neocortex (By similarity). Involved in the control of ciliogenesis and ciliary length (PubMed:25601850, PubMed:27319779). {ECO:0000250|UniProtKB:D3ZR10, ECO:0000269|PubMed:25557784, ECO:0000269|PubMed:25601850, ECO:0000269|PubMed:27319779}. |
| Q9ULI4 | KIF26A | S1687 | ochoa | Kinesin-like protein KIF26A | Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth signaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents GRB2-binding to SHC, thereby attenating the GDNF-Ret signaling (By similarity). Binds to microtubules but lacks microtubule-based motility due to the absence of ATPase activity (By similarity). Plays a critical role in cerebral cortical development. It probably acts as a microtubule stabilizer that regulates neurite growth and radial migration of cortical excitatory neurons (PubMed:36228617). {ECO:0000250|UniProtKB:Q52KG5, ECO:0000269|PubMed:36228617}. |
| Q9ULT0 | TTC7A | S647 | ochoa | Tetratricopeptide repeat protein 7A (TPR repeat protein 7A) | Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:23229899, PubMed:24417819). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (Probable). In the complex, plays a central role in bridging PI4KA to EFR3B and HYCC1, via direct interactions (By similarity). {ECO:0000250|UniProtKB:Q86TV6, ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:24417819}. |
| Q9ULT6 | ZNRF3 | S627 | ochoa | E3 ubiquitin-protein ligase ZNRF3 (EC 2.3.2.27) (RING finger protein 203) (RING-type E3 ubiquitin transferase ZNRF3) (Zinc/RING finger protein 3) | E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby restricting the size of the intestinal stem cell zone (PubMed:22575959). Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification (By similarity). {ECO:0000250|UniProtKB:Q08D68, ECO:0000269|PubMed:22575959}. |
| Q9ULU4 | ZMYND8 | S1126 | ochoa | MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8) | Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) (PubMed:26655721, PubMed:27477906, PubMed:31965980, PubMed:36064715). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac (PubMed:27477906). May also act as a transcriptional corepressor for KDM5C and EZH2 (PubMed:33323928). Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309, PubMed:27732854, PubMed:30134174). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (PubMed:26655721, PubMed:30134174). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression (PubMed:26655721). Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform (PubMed:30134174, PubMed:35916866, PubMed:36064715). Suppresses breast cancer, and prostate cancer cell invasion and metastasis (PubMed:27477906, PubMed:31965980, PubMed:33323928). {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:26655721, ECO:0000269|PubMed:27477906, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:31965980, ECO:0000269|PubMed:33323928, ECO:0000269|PubMed:35916866, ECO:0000269|PubMed:36064715}. |
| Q9UPZ3 | HPS5 | S461 | ochoa | BLOC-2 complex member HPS5 (Alpha-integrin-binding protein 63) (Hermansky-Pudlak syndrome 5 protein) (Ruby-eye protein 2 homolog) (Ru2) | May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. Regulates intracellular vesicular trafficking in fibroblasts. May be involved in the regulation of general functions of integrins. {ECO:0000269|PubMed:15296495, ECO:0000269|PubMed:17301833}. |
| Q9Y483 | MTF2 | S438 | ochoa | Metal-response element-binding transcription factor 2 (Metal regulatory transcription factor 2) (Metal-response element DNA-binding protein M96) (Polycomb-like protein 2) (hPCl2) | Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity (PubMed:23142980, PubMed:23228662, PubMed:31959557). Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation (By similarity). Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells (By similarity). Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex (By similarity). In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally (By similarity). Binds to the metal-regulating-element (MRE) of MT1A gene promoter (By similarity). {ECO:0000250|UniProtKB:Q02395, ECO:0000269|PubMed:23142980, ECO:0000269|PubMed:23228662, ECO:0000269|PubMed:31959557}. |
| Q9Y4G8 | RAPGEF2 | S1313 | ochoa | Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1) | Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Also acts as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP (PubMed:23800469, PubMed:10801446) or not (PubMed:10548487, PubMed:10608844, PubMed:11359771). Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Also provides inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions. {ECO:0000269|PubMed:10548487, ECO:0000269|PubMed:10608844, ECO:0000269|PubMed:10608883, ECO:0000269|PubMed:10801446, ECO:0000269|PubMed:10934204, ECO:0000269|PubMed:11359771, ECO:0000269|PubMed:12391161, ECO:0000269|PubMed:16272156, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:23800469}. |
| Q9Y597 | KCTD3 | S148 | ochoa | BTB/POZ domain-containing protein KCTD3 (Renal carcinoma antigen NY-REN-45) | Accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) up-regulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. {ECO:0000250|UniProtKB:Q8BFX3}. |
| Q9Y608 | LRRFIP2 | S190 | ochoa|psp | Leucine-rich repeat flightless-interacting protein 2 (LRR FLII-interacting protein 2) | May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:15677333, ECO:0000269|PubMed:19265123}. |
| Q9Y6Q5 | AP1M2 | S63 | ochoa | AP-1 complex subunit mu-2 (AP-mu chain family member mu1B) (Adaptor protein complex AP-1 subunit mu-2) (Adaptor-related protein complex 1 subunit mu-2) (Clathrin assembly protein complex 1 mu-2 medium chain 2) (Golgi adaptor HA1/AP1 adaptin mu-2 subunit) (Mu-adaptin 2) (Mu1B-adaptin) | Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. |
| P49585 | PCYT1A | S68 | Sugiyama | Choline-phosphate cytidylyltransferase A (EC 2.7.7.15) (CCT-alpha) (CTP:phosphocholine cytidylyltransferase A) (CCT A) (CT A) (Phosphorylcholine transferase A) | Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. {ECO:0000269|PubMed:10480912, ECO:0000269|PubMed:30559292, ECO:0000269|PubMed:7918629}. |
| P43146 | DCC | Y1261 | SIGNOR | Netrin receptor DCC (Colorectal cancer suppressor) (Immunoglobulin superfamily DCC subclass member 1) (Tumor suppressor protein DCC) | Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene. {ECO:0000269|PubMed:8187090, ECO:0000269|PubMed:8861902}. |
| Q8IZQ8 | MYOCD | S815 | GPS6 | Myocardin | Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis, urinary bladder development, and differentiation of the smooth muscle cell lineage (myogenesis) (By similarity). Positively regulates the transcription of genes involved in vascular smooth muscle contraction (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q8R5I7, ECO:0000269|PubMed:12640126, ECO:0000269|PubMed:31513549}. |
| O15169 | AXIN1 | S46 | SIGNOR | Axin-1 (Axis inhibition protein 1) (hAxin) | Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (PubMed:12192039, PubMed:27098453, PubMed:28829046). Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway (PubMed:12192039). In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B (PubMed:12192039). Likely to function as a tumor suppressor. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (PubMed:16601693). Also a component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development (PubMed:17210684). Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation (PubMed:17210684). {ECO:0000269|PubMed:12192039, ECO:0000269|PubMed:16601693, ECO:0000269|PubMed:17210684, ECO:0000269|PubMed:27098453, ECO:0000269|PubMed:28546513}. |
| Q8IZQ8 | MYOCD | S455 | SIGNOR|iPTMNet|EPSD | Myocardin | Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis, urinary bladder development, and differentiation of the smooth muscle cell lineage (myogenesis) (By similarity). Positively regulates the transcription of genes involved in vascular smooth muscle contraction (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q8R5I7, ECO:0000269|PubMed:12640126, ECO:0000269|PubMed:31513549}. |
| P35869 | AHR | S489 | SIGNOR | Aryl hydrocarbon receptor (Ah receptor) (AhR) (Class E basic helix-loop-helix protein 76) (bHLHe76) | Ligand-activated transcription factor that enables cells to adapt to changing conditions by sensing compounds from the environment, diet, microbiome and cellular metabolism, and which plays important roles in development, immunity and cancer (PubMed:23275542, PubMed:30373764, PubMed:32818467, PubMed:7961644). Upon ligand binding, translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE) (PubMed:23275542, PubMed:30373764, PubMed:7961644). Regulates a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation (PubMed:12213388). Xenobiotics can act as ligands: upon xenobiotic-binding, activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene) (PubMed:7961644, PubMed:33193710). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons (PubMed:34521881, PubMed:7961644). Next to xenobiotics, natural ligands derived from plants, microbiota, and endogenous metabolism are potent AHR agonists (PubMed:18076143). Tryptophan (Trp) derivatives constitute an important class of endogenous AHR ligands (PubMed:32818467, PubMed:32866000). Acts as a negative regulator of anti-tumor immunity: indoles and kynurenic acid generated by Trp catabolism act as ligand and activate AHR, thereby promoting AHR-driven cancer cell motility and suppressing adaptive immunity (PubMed:32818467). Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1 (PubMed:28602820). Inhibits PER1 by repressing the CLOCK-BMAL1 heterodimer mediated transcriptional activation of PER1 (PubMed:28602820). The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28602820). {ECO:0000269|PubMed:23275542, ECO:0000269|PubMed:28602820, ECO:0000269|PubMed:30373764, ECO:0000269|PubMed:32818467, ECO:0000269|PubMed:32866000, ECO:0000269|PubMed:33193710, ECO:0000269|PubMed:34521881, ECO:0000269|PubMed:7961644, ECO:0000303|PubMed:12213388, ECO:0000303|PubMed:18076143}. |
| P42892 | ECE1 | S735 | Sugiyama | Endothelin-converting enzyme 1 (ECE-1) (EC 3.4.24.71) | Converts big endothelin-1 to endothelin-1. {ECO:0000269|PubMed:37835445, ECO:0000269|PubMed:9396733}. |
| Q8IWW6 | ARHGAP12 | S450 | Sugiyama | Rho GTPase-activating protein 12 (Rho-type GTPase-activating protein 12) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| Q8TEQ6 | GEMIN5 | S648 | Sugiyama | Gem-associated protein 5 (Gemin5) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:16857593, PubMed:18984161, PubMed:20513430, PubMed:33963192). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:18984161). To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate (PubMed:18984161). Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. Within the SMN complex, GEMIN5 recognizes and delivers the small nuclear RNAs (snRNAs) to the SMN complex (PubMed:11714716, PubMed:16314521, PubMed:16857593, PubMed:19377484, PubMed:19750007, PubMed:20513430, PubMed:27834343, PubMed:27881600, PubMed:27881601). Binds to the 7-methylguanosine cap of RNA molecules (PubMed:19750007, PubMed:27834343, PubMed:27881600, PubMed:27881601, Ref.27). Binds to the 3'-UTR of SMN1 mRNA and regulates its translation; does not affect mRNA stability (PubMed:25911097). May play a role in the regulation of protein synthesis via its interaction with ribosomes (PubMed:27507887). {ECO:0000269|PubMed:11714716, ECO:0000269|PubMed:16314521, ECO:0000269|PubMed:16857593, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:19377484, ECO:0000269|PubMed:19750007, ECO:0000269|PubMed:20513430, ECO:0000269|PubMed:25911097, ECO:0000269|PubMed:27507887, ECO:0000269|PubMed:27834343, ECO:0000269|PubMed:27881600, ECO:0000269|PubMed:27881601, ECO:0000269|PubMed:33963192, ECO:0000269|Ref.27}. |
| Q14164 | IKBKE | S519 | Sugiyama | Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i) | Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA sensors, such as RIG-I-like receptors, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRF3 leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB. In order to establish such an antiviral state, IKBKE forms several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or TBKBP1/SINTBAD can be recruited to the IKBKE-containing-complexes. Activated by polyubiquitination in response to TNFA and interleukin-1, regulates the NF-kappa-B signaling pathway through, at least, the phosphorylation of CYLD. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. In addition, is also required for the induction of a subset of ISGs which displays antiviral activity, may be through the phosphorylation of STAT1 at 'Ser-708'. Phosphorylation of STAT1 at 'Ser-708' also seems to promote the assembly and DNA binding of ISGF3 (STAT1:STAT2:IRF9) complexes compared to GAF (STAT1:STAT1) complexes, in this way regulating the balance between type I and type II IFN responses. Protects cells against DNA damage-induced cell death. Also plays an important role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Phosphorylates AKT1. {ECO:0000269|PubMed:17568778, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:19153231, ECO:0000269|PubMed:20188669, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:21464307, ECO:0000269|PubMed:22532683, ECO:0000269|PubMed:23453969, ECO:0000269|PubMed:23478265}. |
| O00562 | PITPNM1 | S331 | Sugiyama | Membrane-associated phosphatidylinositol transfer protein 1 (Drosophila retinal degeneration B homolog) (Phosphatidylinositol transfer protein, membrane-associated 1) (PITPnm 1) (Pyk2 N-terminal domain-interacting receptor 2) (NIR-2) | Catalyzes the transfer of phosphatidylinositol (PI) between membranes (PubMed:10531358, PubMed:22822086). Binds PI, phosphatidylcholine (PC) and phosphatidic acid (PA) with the binding affinity order of PI > PA > PC (PubMed:22822086). Regulates RHOA activity, and plays a role in cytoskeleton remodeling (PubMed:11909959). Necessary for normal completion of cytokinesis (PubMed:15125835). Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus (PubMed:15723057). Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus (PubMed:15545272). Required for protein export from the endoplasmic reticulum and the Golgi (PubMed:15723057). Binds calcium ions (PubMed:10022914). {ECO:0000269|PubMed:10022914, ECO:0000269|PubMed:10531358, ECO:0000269|PubMed:11909959, ECO:0000269|PubMed:15545272, ECO:0000269|PubMed:15723057, ECO:0000269|PubMed:22822086}. |
| Q6EMK4 | VASN | S487 | Sugiyama | Vasorin (Protein slit-like 2) | May act as an inhibitor of TGF-beta signaling. {ECO:0000269|PubMed:15247411}. |
| Q8TD08 | MAPK15 | S259 | Sugiyama | Mitogen-activated protein kinase 15 (MAP kinase 15) (MAPK 15) (EC 2.7.11.24) (Extracellular signal-regulated kinase 7) (ERK-7) (Extracellular signal-regulated kinase 8) (ERK-8) | Atypical MAPK protein that regulates several process such as autophagy, ciliogenesis, protein trafficking/secretion and genome integrity, in a kinase activity-dependent manner (PubMed:20733054, PubMed:21847093, PubMed:22948227, PubMed:24618899, PubMed:29021280). Controls both, basal and starvation-induced autophagy throught its interaction with GABARAP, MAP1LC3B and GABARAPL1 leading to autophagosome formation, SQSTM1 degradation and reduced MAP1LC3B inhibitory phosphorylation (PubMed:22948227). Regulates primary cilium formation and the localization of ciliary proteins involved in cilium structure, transport, and signaling (PubMed:29021280). Prevents the relocation of the sugar-adding enzymes from the Golgi to the endoplasmic reticulum, thereby restricting the production of sugar-coated proteins (PubMed:24618899). Upon amino-acid starvation, mediates transitional endoplasmic reticulum site disassembly and inhibition of secretion (PubMed:21847093). Binds to chromatin leading to MAPK15 activation and interaction with PCNA, that which protects genomic integrity by inhibiting MDM2-mediated degradation of PCNA (PubMed:20733054). Regulates DA transporter (DAT) activity and protein expression via activation of RhoA (PubMed:28842414). In response to H(2)O(2) treatment phosphorylates ELAVL1, thus preventing it from binding to the PDCD4 3'UTR and rendering the PDCD4 mRNA accessible to miR-21 and leading to its degradation and loss of protein expression (PubMed:26595526). Also functions in a kinase activity-independent manner as a negative regulator of growth (By similarity). Phosphorylates in vitro FOS and MBP (PubMed:11875070, PubMed:16484222, PubMed:19166846, PubMed:20638370). During oocyte maturation, plays a key role in the microtubule organization and meiotic cell cycle progression in oocytes, fertilized eggs, and early embryos (By similarity). Interacts with ESRRA promoting its re-localization from the nucleus to the cytoplasm and then prevents its transcriptional activity (PubMed:21190936). {ECO:0000250|UniProtKB:Q80Y86, ECO:0000250|UniProtKB:Q9Z2A6, ECO:0000269|PubMed:11875070, ECO:0000269|PubMed:16484222, ECO:0000269|PubMed:19166846, ECO:0000269|PubMed:20638370, ECO:0000269|PubMed:20733054, ECO:0000269|PubMed:21190936, ECO:0000269|PubMed:21847093, ECO:0000269|PubMed:22948227, ECO:0000269|PubMed:24618899, ECO:0000269|PubMed:26595526, ECO:0000269|PubMed:28842414, ECO:0000269|PubMed:29021280}. |
| Q9Y2U5 | MAP3K2 | S21 | Sugiyama | Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2) | Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics. {ECO:0000250, ECO:0000269|PubMed:10713157, ECO:0000269|PubMed:16001074}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9707616 | Heme signaling | 0.000317 | 3.498 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 0.001008 | 2.997 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.003071 | 2.513 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.002614 | 2.583 |
| R-HSA-1059683 | Interleukin-6 signaling | 0.001440 | 2.842 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.001271 | 2.896 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.002220 | 2.654 |
| R-HSA-9909396 | Circadian clock | 0.003201 | 2.495 |
| R-HSA-9733709 | Cardiogenesis | 0.001700 | 2.770 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.003101 | 2.508 |
| R-HSA-5467345 | Deletions in the AXIN1 gene destabilize the destruction complex | 0.012712 | 1.896 |
| R-HSA-5632987 | Defective Mismatch Repair Associated With PMS2 | 0.025262 | 1.598 |
| R-HSA-4793954 | Defective MOGS causes CDG-2b | 0.025262 | 1.598 |
| R-HSA-5545483 | Defective Mismatch Repair Associated With MLH1 | 0.025262 | 1.598 |
| R-HSA-1299316 | TWIK-releated acid-sensitive K+ channel (TASK) | 0.037654 | 1.424 |
| R-HSA-5602636 | IKBKB deficiency causes SCID | 0.037654 | 1.424 |
| R-HSA-5603027 | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... | 0.037654 | 1.424 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 0.008983 | 2.047 |
| R-HSA-211163 | AKT-mediated inactivation of FOXO1A | 0.073897 | 1.131 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 0.014192 | 1.848 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.016157 | 1.792 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 0.097301 | 1.012 |
| R-HSA-8985586 | SLIT2:ROBO1 increases RHOA activity | 0.097301 | 1.012 |
| R-HSA-8866423 | VLDL assembly | 0.108782 | 0.963 |
| R-HSA-8964026 | Chylomicron clearance | 0.108782 | 0.963 |
| R-HSA-6802953 | RAS signaling downstream of NF1 loss-of-function variants | 0.108782 | 0.963 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 0.025077 | 1.601 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 0.120117 | 0.920 |
| R-HSA-8964046 | VLDL clearance | 0.120117 | 0.920 |
| R-HSA-9632974 | NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis | 0.120117 | 0.920 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 0.038393 | 1.416 |
| R-HSA-9634635 | Estrogen-stimulated signaling through PRKCZ | 0.142358 | 0.847 |
| R-HSA-8963888 | Chylomicron assembly | 0.164040 | 0.785 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.164040 | 0.785 |
| R-HSA-112308 | Presynaptic depolarization and calcium channel opening | 0.164040 | 0.785 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.164040 | 0.785 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.164040 | 0.785 |
| R-HSA-3000497 | Scavenging by Class H Receptors | 0.174676 | 0.758 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.174676 | 0.758 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.174676 | 0.758 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.185177 | 0.732 |
| R-HSA-3656237 | Defective EXT2 causes exostoses 2 | 0.185177 | 0.732 |
| R-HSA-3656253 | Defective EXT1 causes exostoses 1, TRPS2 and CHDS | 0.185177 | 0.732 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 0.185177 | 0.732 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.185177 | 0.732 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.185177 | 0.732 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.185177 | 0.732 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.185177 | 0.732 |
| R-HSA-8963901 | Chylomicron remodeling | 0.195545 | 0.709 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.078306 | 1.106 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.082047 | 1.086 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.082047 | 1.086 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.215888 | 0.666 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.215888 | 0.666 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.089690 | 1.047 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.089690 | 1.047 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.093588 | 1.029 |
| R-HSA-176412 | Phosphorylation of the APC/C | 0.225867 | 0.646 |
| R-HSA-5083625 | Defective GALNT3 causes HFTC | 0.225867 | 0.646 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 0.225867 | 0.646 |
| R-HSA-5083636 | Defective GALNT12 causes CRCS1 | 0.225867 | 0.646 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.101526 | 0.993 |
| R-HSA-3560783 | Defective B4GALT7 causes EDS, progeroid type | 0.235720 | 0.628 |
| R-HSA-4420332 | Defective B3GALT6 causes EDSP2 and SEMDJL1 | 0.235720 | 0.628 |
| R-HSA-5083632 | Defective C1GALT1C1 causes TNPS | 0.245448 | 0.610 |
| R-HSA-3560801 | Defective B3GAT3 causes JDSSDHD | 0.245448 | 0.610 |
| R-HSA-191859 | snRNP Assembly | 0.055609 | 1.255 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.055609 | 1.255 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.117924 | 0.928 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.122122 | 0.913 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 0.264535 | 0.578 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.264535 | 0.578 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.273898 | 0.562 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.273898 | 0.562 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.273898 | 0.562 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.273898 | 0.562 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.283142 | 0.548 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.170354 | 0.769 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.164652 | 0.783 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.301130 | 0.521 |
| R-HSA-1989781 | PPARA activates gene expression | 0.182391 | 0.739 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.035552 | 1.449 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.187479 | 0.727 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.130625 | 0.884 |
| R-HSA-5689877 | Josephin domain DUBs | 0.012339 | 1.909 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 0.292269 | 0.534 |
| R-HSA-163358 | PKA-mediated phosphorylation of key metabolic factors | 0.097301 | 1.012 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 0.097301 | 1.012 |
| R-HSA-3000471 | Scavenging by Class B Receptors | 0.235720 | 0.628 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.255052 | 0.593 |
| R-HSA-163767 | PP2A-mediated dephosphorylation of key metabolic factors | 0.120117 | 0.920 |
| R-HSA-418886 | Netrin mediated repulsion signals | 0.120117 | 0.920 |
| R-HSA-164940 | Nef mediated downregulation of MHC class I complex cell surface expression | 0.131308 | 0.882 |
| R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 0.142358 | 0.847 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 0.195545 | 0.709 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.235720 | 0.628 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.277590 | 0.557 |
| R-HSA-525793 | Myogenesis | 0.008350 | 2.078 |
| R-HSA-373752 | Netrin-1 signaling | 0.143623 | 0.843 |
| R-HSA-1606341 | IRF3 mediated activation of type 1 IFN | 0.085674 | 1.067 |
| R-HSA-165158 | Activation of AKT2 | 0.085674 | 1.067 |
| R-HSA-8964041 | LDL remodeling | 0.120117 | 0.920 |
| R-HSA-164843 | 2-LTR circle formation | 0.153268 | 0.815 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.205781 | 0.687 |
| R-HSA-4641263 | Regulation of FZD by ubiquitination | 0.245448 | 0.610 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 0.245448 | 0.610 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.028277 | 1.549 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.085674 | 1.067 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 0.016157 | 1.792 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 0.022694 | 1.644 |
| R-HSA-428542 | Regulation of commissural axon pathfinding by SLIT and ROBO | 0.142358 | 0.847 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 0.164040 | 0.785 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 0.215888 | 0.666 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.079698 | 1.099 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.156879 | 0.804 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.078306 | 1.106 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.263439 | 0.579 |
| R-HSA-5693538 | Homology Directed Repair | 0.028303 | 1.548 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.085843 | 1.066 |
| R-HSA-6783589 | Interleukin-6 family signaling | 0.007009 | 2.154 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.035552 | 1.449 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 0.225867 | 0.646 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.006113 | 2.214 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.005166 | 2.287 |
| R-HSA-5358508 | Mismatch Repair | 0.255052 | 0.593 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.005166 | 2.287 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.089690 | 1.047 |
| R-HSA-373756 | SDK interactions | 0.025262 | 1.598 |
| R-HSA-8939256 | RUNX1 regulates transcription of genes involved in WNT signaling | 0.006115 | 2.214 |
| R-HSA-3249367 | STAT6-mediated induction of chemokines | 0.061970 | 1.208 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 0.097301 | 1.012 |
| R-HSA-69478 | G2/M DNA replication checkpoint | 0.108782 | 0.963 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 0.120117 | 0.920 |
| R-HSA-418889 | Caspase activation via Dependence Receptors in the absence of ligand | 0.142358 | 0.847 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 0.153268 | 0.815 |
| R-HSA-4839744 | Signaling by APC mutants | 0.164040 | 0.785 |
| R-HSA-209560 | NF-kB is activated and signals survival | 0.174676 | 0.758 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.174676 | 0.758 |
| R-HSA-418890 | Role of second messengers in netrin-1 signaling | 0.185177 | 0.732 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.215888 | 0.666 |
| R-HSA-5576886 | Phase 4 - resting membrane potential | 0.225867 | 0.646 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.235720 | 0.628 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.109643 | 0.960 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 0.245448 | 0.610 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.148015 | 0.830 |
| R-HSA-109704 | PI3K Cascade | 0.170354 | 0.769 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.130625 | 0.884 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.030131 | 1.521 |
| R-HSA-9694614 | Attachment and Entry | 0.292269 | 0.534 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 0.235720 | 0.628 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 0.245448 | 0.610 |
| R-HSA-432142 | Platelet sensitization by LDL | 0.255052 | 0.593 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.105563 | 0.976 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.020810 | 1.682 |
| R-HSA-165159 | MTOR signalling | 0.134927 | 0.870 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.006903 | 2.161 |
| R-HSA-937042 | IRAK2 mediated activation of TAK1 complex | 0.142358 | 0.847 |
| R-HSA-9020956 | Interleukin-27 signaling | 0.153268 | 0.815 |
| R-HSA-9762292 | Regulation of CDH11 function | 0.153268 | 0.815 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.067425 | 1.171 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 0.215888 | 0.666 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.093588 | 1.029 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 0.273898 | 0.562 |
| R-HSA-8984722 | Interleukin-35 Signalling | 0.185177 | 0.732 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.109643 | 0.960 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.079455 | 1.100 |
| R-HSA-8931987 | RUNX1 regulates estrogen receptor mediated transcription | 0.007487 | 2.126 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.195545 | 0.709 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.117924 | 0.928 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.017997 | 1.745 |
| R-HSA-202403 | TCR signaling | 0.021099 | 1.676 |
| R-HSA-376172 | DSCAM interactions | 0.049889 | 1.302 |
| R-HSA-5423599 | Diseases of Mismatch Repair (MMR) | 0.061970 | 1.208 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 0.097301 | 1.012 |
| R-HSA-8981373 | Intestinal hexose absorption | 0.097301 | 1.012 |
| R-HSA-112411 | MAPK1 (ERK2) activation | 0.142358 | 0.847 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.044323 | 1.353 |
| R-HSA-1483226 | Synthesis of PI | 0.164040 | 0.785 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 0.185177 | 0.732 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 0.215888 | 0.666 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.235720 | 0.628 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.273898 | 0.562 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 0.283142 | 0.548 |
| R-HSA-112399 | IRS-mediated signalling | 0.202457 | 0.694 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.221098 | 0.655 |
| R-HSA-975634 | Retinoid metabolism and transport | 0.268156 | 0.572 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.004867 | 2.313 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.069414 | 1.159 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 0.264535 | 0.578 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.006054 | 2.218 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.152448 | 0.817 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 0.063920 | 1.194 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 0.025077 | 1.601 |
| R-HSA-6788467 | IL-6-type cytokine receptor ligand interactions | 0.195545 | 0.709 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.097534 | 1.011 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.005024 | 2.299 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.126356 | 0.898 |
| R-HSA-73894 | DNA Repair | 0.010406 | 1.983 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.164652 | 0.783 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.164652 | 0.783 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.164652 | 0.783 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.071078 | 1.148 |
| R-HSA-9022707 | MECP2 regulates transcription factors | 0.007487 | 2.126 |
| R-HSA-444257 | RSK activation | 0.131308 | 0.882 |
| R-HSA-198693 | AKT phosphorylates targets in the nucleus | 0.142358 | 0.847 |
| R-HSA-163680 | AMPK inhibits chREBP transcriptional activation activity | 0.142358 | 0.847 |
| R-HSA-9683686 | Maturation of spike protein | 0.153268 | 0.815 |
| R-HSA-110056 | MAPK3 (ERK1) activation | 0.153268 | 0.815 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.174676 | 0.758 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 0.185177 | 0.732 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 0.185177 | 0.732 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 0.205781 | 0.687 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 0.245448 | 0.610 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.117924 | 0.928 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.122122 | 0.913 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.122122 | 0.913 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.126356 | 0.898 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.089062 | 1.050 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.221098 | 0.655 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.025258 | 1.598 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.068014 | 1.167 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.242823 | 0.615 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.077934 | 1.108 |
| R-HSA-193639 | p75NTR signals via NF-kB | 0.215888 | 0.666 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.211757 | 0.674 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.242823 | 0.615 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.253023 | 0.597 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.253023 | 0.597 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.097534 | 1.011 |
| R-HSA-9675135 | Diseases of DNA repair | 0.152434 | 0.817 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 0.097301 | 1.012 |
| R-HSA-9645460 | Alpha-protein kinase 1 signaling pathway | 0.164040 | 0.785 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.164040 | 0.785 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 0.245448 | 0.610 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.113764 | 0.944 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.152434 | 0.817 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 0.292269 | 0.534 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.272874 | 0.564 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.239438 | 0.621 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.249292 | 0.603 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.235170 | 0.629 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.195196 | 0.710 |
| R-HSA-1640170 | Cell Cycle | 0.225625 | 0.647 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.101526 | 0.993 |
| R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 0.097301 | 1.012 |
| R-HSA-8963676 | Intestinal absorption | 0.131308 | 0.882 |
| R-HSA-1296346 | Tandem pore domain potassium channels | 0.153268 | 0.815 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.016160 | 1.792 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.053801 | 1.269 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 0.245448 | 0.610 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.117924 | 0.928 |
| R-HSA-69481 | G2/M Checkpoints | 0.110529 | 0.957 |
| R-HSA-2559583 | Cellular Senescence | 0.113771 | 0.944 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.282304 | 0.549 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.239873 | 0.620 |
| R-HSA-450294 | MAP kinase activation | 0.059650 | 1.224 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.212690 | 0.672 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.202457 | 0.694 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.259857 | 0.585 |
| R-HSA-68875 | Mitotic Prophase | 0.246215 | 0.609 |
| R-HSA-75205 | Dissolution of Fibrin Clot | 0.164040 | 0.785 |
| R-HSA-162592 | Integration of provirus | 0.174676 | 0.758 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 0.245448 | 0.610 |
| R-HSA-448424 | Interleukin-17 signaling | 0.079455 | 1.100 |
| R-HSA-198753 | ERK/MAPK targets | 0.283142 | 0.548 |
| R-HSA-983189 | Kinesins | 0.216423 | 0.665 |
| R-HSA-5688426 | Deubiquitination | 0.026270 | 1.581 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.225782 | 0.646 |
| R-HSA-75893 | TNF signaling | 0.009642 | 2.016 |
| R-HSA-162906 | HIV Infection | 0.211109 | 0.675 |
| R-HSA-162587 | HIV Life Cycle | 0.187479 | 0.727 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.126356 | 0.898 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.158513 | 0.800 |
| R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 0.120117 | 0.920 |
| R-HSA-977347 | Serine metabolism | 0.292269 | 0.534 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.101839 | 0.992 |
| R-HSA-212436 | Generic Transcription Pathway | 0.281143 | 0.551 |
| R-HSA-8939211 | ESR-mediated signaling | 0.048731 | 1.312 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.032769 | 1.485 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.014583 | 1.836 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.235170 | 0.629 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.183475 | 0.736 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.301130 | 0.521 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.123338 | 0.909 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.079698 | 1.099 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.221372 | 0.655 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.063920 | 1.194 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 0.185177 | 0.732 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 0.225867 | 0.646 |
| R-HSA-9833110 | RSV-host interactions | 0.186666 | 0.729 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.226981 | 0.644 |
| R-HSA-73887 | Death Receptor Signaling | 0.071486 | 1.146 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.215888 | 0.666 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 0.035552 | 1.449 |
| R-HSA-180292 | GAB1 signalosome | 0.255052 | 0.593 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 0.264535 | 0.578 |
| R-HSA-9824446 | Viral Infection Pathways | 0.218055 | 0.661 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.235170 | 0.629 |
| R-HSA-3000178 | ECM proteoglycans | 0.268156 | 0.572 |
| R-HSA-2262752 | Cellular responses to stress | 0.179148 | 0.747 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.071823 | 1.144 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.109643 | 0.960 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.255052 | 0.593 |
| R-HSA-9679506 | SARS-CoV Infections | 0.035239 | 1.453 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.284700 | 0.546 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.207101 | 0.684 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.082047 | 1.086 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.229335 | 0.640 |
| R-HSA-9694631 | Maturation of nucleoprotein | 0.264535 | 0.578 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.222646 | 0.652 |
| R-HSA-194138 | Signaling by VEGF | 0.266716 | 0.574 |
| R-HSA-3371556 | Cellular response to heat stress | 0.249615 | 0.603 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.255052 | 0.593 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.296430 | 0.528 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.249946 | 0.602 |
| R-HSA-162582 | Signal Transduction | 0.210077 | 0.678 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.066149 | 1.179 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.106970 | 0.971 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.287016 | 0.542 |
| R-HSA-202433 | Generation of second messenger molecules | 0.122122 | 0.913 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.197825 | 0.704 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.179865 | 0.745 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.236062 | 0.627 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 0.283142 | 0.548 |
| R-HSA-177929 | Signaling by EGFR | 0.197825 | 0.704 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.039816 | 1.400 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.255052 | 0.593 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.179442 | 0.746 |
| R-HSA-8964038 | LDL clearance | 0.301280 | 0.521 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.301280 | 0.521 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 0.301280 | 0.521 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.301280 | 0.521 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.301280 | 0.521 |
| R-HSA-977068 | Termination of O-glycan biosynthesis | 0.310178 | 0.508 |
| R-HSA-392451 | G beta:gamma signalling through PI3Kgamma | 0.310178 | 0.508 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 0.310178 | 0.508 |
| R-HSA-1855167 | Synthesis of pyrophosphates in the cytosol | 0.310178 | 0.508 |
| R-HSA-9833482 | PKR-mediated signaling | 0.310514 | 0.508 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.315181 | 0.501 |
| R-HSA-6806667 | Metabolism of fat-soluble vitamins | 0.315196 | 0.501 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.316714 | 0.499 |
| R-HSA-8963898 | Plasma lipoprotein assembly | 0.318962 | 0.496 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.318962 | 0.496 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 0.318962 | 0.496 |
| R-HSA-429947 | Deadenylation of mRNA | 0.318962 | 0.496 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.319872 | 0.495 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.325619 | 0.487 |
| R-HSA-9664407 | Parasite infection | 0.325619 | 0.487 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.325619 | 0.487 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.327635 | 0.485 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.327635 | 0.485 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.327635 | 0.485 |
| R-HSA-3000157 | Laminin interactions | 0.327635 | 0.485 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 0.327635 | 0.485 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 0.327635 | 0.485 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.329098 | 0.483 |
| R-HSA-1632852 | Macroautophagy | 0.329098 | 0.483 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.330053 | 0.481 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.333851 | 0.476 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.336056 | 0.474 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.336198 | 0.473 |
| R-HSA-3295583 | TRP channels | 0.336198 | 0.473 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.336198 | 0.473 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 0.336198 | 0.473 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.343011 | 0.465 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.344653 | 0.463 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.344653 | 0.463 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.344653 | 0.463 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 0.344653 | 0.463 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.353001 | 0.452 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.361242 | 0.442 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 0.361242 | 0.442 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.361242 | 0.442 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.361242 | 0.442 |
| R-HSA-202424 | Downstream TCR signaling | 0.361546 | 0.442 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.366122 | 0.436 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.369379 | 0.433 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.369379 | 0.433 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.369379 | 0.433 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.370756 | 0.431 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.375237 | 0.426 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.375237 | 0.426 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 0.377413 | 0.423 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.377413 | 0.423 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.379537 | 0.421 |
| R-HSA-9612973 | Autophagy | 0.384555 | 0.415 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.385346 | 0.414 |
| R-HSA-2024096 | HS-GAG degradation | 0.385346 | 0.414 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.385346 | 0.414 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.393177 | 0.405 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.393177 | 0.405 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.393177 | 0.405 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.393177 | 0.405 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.393177 | 0.405 |
| R-HSA-397795 | G-protein beta:gamma signalling | 0.393177 | 0.405 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.393177 | 0.405 |
| R-HSA-354192 | Integrin signaling | 0.393177 | 0.405 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.397781 | 0.400 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.397781 | 0.400 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.400909 | 0.397 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.400909 | 0.397 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 0.400909 | 0.397 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.400909 | 0.397 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.400909 | 0.397 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.402246 | 0.396 |
| R-HSA-74160 | Gene expression (Transcription) | 0.402874 | 0.395 |
| R-HSA-1971475 | Glycosaminoglycan-protein linkage region biosynthesis | 0.408544 | 0.389 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.408544 | 0.389 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.408544 | 0.389 |
| R-HSA-5205647 | Mitophagy | 0.408544 | 0.389 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.408544 | 0.389 |
| R-HSA-5673000 | RAF activation | 0.408544 | 0.389 |
| R-HSA-5686938 | Regulation of TLR by endogenous ligand | 0.408544 | 0.389 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 0.408544 | 0.389 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.408881 | 0.388 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.411128 | 0.386 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.411128 | 0.386 |
| R-HSA-68886 | M Phase | 0.411630 | 0.385 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.415545 | 0.381 |
| R-HSA-70171 | Glycolysis | 0.415545 | 0.381 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.416081 | 0.381 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.419945 | 0.377 |
| R-HSA-2022928 | HS-GAG biosynthesis | 0.423523 | 0.373 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.423523 | 0.373 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 0.423523 | 0.373 |
| R-HSA-9845576 | Glycosphingolipid transport | 0.423523 | 0.373 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.423523 | 0.373 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.424329 | 0.372 |
| R-HSA-4641257 | Degradation of AXIN | 0.430870 | 0.366 |
| R-HSA-549127 | SLC-mediated transport of organic cations | 0.430870 | 0.366 |
| R-HSA-419037 | NCAM1 interactions | 0.430870 | 0.366 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.438102 | 0.358 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.438125 | 0.358 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.439827 | 0.357 |
| R-HSA-449147 | Signaling by Interleukins | 0.444998 | 0.352 |
| R-HSA-69541 | Stabilization of p53 | 0.445287 | 0.351 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 0.445287 | 0.351 |
| R-HSA-3781860 | Diseases associated with N-glycosylation of proteins | 0.445287 | 0.351 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.448935 | 0.348 |
| R-HSA-211000 | Gene Silencing by RNA | 0.450262 | 0.347 |
| R-HSA-4839726 | Chromatin organization | 0.451439 | 0.345 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.452358 | 0.345 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.452358 | 0.345 |
| R-HSA-5260271 | Diseases of Immune System | 0.452358 | 0.345 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.452358 | 0.345 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.454520 | 0.342 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.454520 | 0.342 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.459340 | 0.338 |
| R-HSA-9694548 | Maturation of spike protein | 0.459340 | 0.338 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.459340 | 0.338 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.459340 | 0.338 |
| R-HSA-167161 | HIV Transcription Initiation | 0.466233 | 0.331 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.466233 | 0.331 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.466233 | 0.331 |
| R-HSA-3000480 | Scavenging by Class A Receptors | 0.466233 | 0.331 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.466233 | 0.331 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.466233 | 0.331 |
| R-HSA-9683701 | Translation of Structural Proteins | 0.466233 | 0.331 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.473038 | 0.325 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 0.473038 | 0.325 |
| R-HSA-73928 | Depyrimidination | 0.473038 | 0.325 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.478504 | 0.320 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.479758 | 0.319 |
| R-HSA-3781865 | Diseases of glycosylation | 0.481745 | 0.317 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.486392 | 0.313 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.492941 | 0.307 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.492941 | 0.307 |
| R-HSA-3560782 | Diseases associated with glycosaminoglycan metabolism | 0.492941 | 0.307 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 0.492941 | 0.307 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.492941 | 0.307 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.499408 | 0.302 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.499408 | 0.302 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.499408 | 0.302 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.499408 | 0.302 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.499408 | 0.302 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.499408 | 0.302 |
| R-HSA-70326 | Glucose metabolism | 0.500079 | 0.301 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.505793 | 0.296 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 0.505793 | 0.296 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.505793 | 0.296 |
| R-HSA-1483191 | Synthesis of PC | 0.505793 | 0.296 |
| R-HSA-8963899 | Plasma lipoprotein remodeling | 0.512096 | 0.291 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.512096 | 0.291 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.518320 | 0.285 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.518320 | 0.285 |
| R-HSA-9766229 | Degradation of CDH1 | 0.518320 | 0.285 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 0.518320 | 0.285 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.523886 | 0.281 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.523886 | 0.281 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.530531 | 0.275 |
| R-HSA-9864848 | Complex IV assembly | 0.530531 | 0.275 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.530531 | 0.275 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.530531 | 0.275 |
| R-HSA-912446 | Meiotic recombination | 0.530531 | 0.275 |
| R-HSA-446728 | Cell junction organization | 0.530558 | 0.275 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.532233 | 0.274 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.536520 | 0.270 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.541393 | 0.266 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.542434 | 0.266 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.542434 | 0.266 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.542434 | 0.266 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.542434 | 0.266 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 0.542434 | 0.266 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.548272 | 0.261 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.548272 | 0.261 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 0.548272 | 0.261 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.554036 | 0.256 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.554036 | 0.256 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.559106 | 0.253 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.559727 | 0.252 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.559727 | 0.252 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.559727 | 0.252 |
| R-HSA-9843745 | Adipogenesis | 0.561847 | 0.250 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.565346 | 0.248 |
| R-HSA-5621480 | Dectin-2 family | 0.565346 | 0.248 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.565346 | 0.248 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.565523 | 0.248 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.570893 | 0.243 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.574081 | 0.241 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.574281 | 0.241 |
| R-HSA-1638091 | Heparan sulfate/heparin (HS-GAG) metabolism | 0.576370 | 0.239 |
| R-HSA-186712 | Regulation of beta-cell development | 0.576370 | 0.239 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.576370 | 0.239 |
| R-HSA-180786 | Extension of Telomeres | 0.576370 | 0.239 |
| R-HSA-597592 | Post-translational protein modification | 0.578099 | 0.238 |
| R-HSA-195721 | Signaling by WNT | 0.581759 | 0.235 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.581778 | 0.235 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.581778 | 0.235 |
| R-HSA-163685 | Integration of energy metabolism | 0.583570 | 0.234 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.587116 | 0.231 |
| R-HSA-211976 | Endogenous sterols | 0.587116 | 0.231 |
| R-HSA-445717 | Aquaporin-mediated transport | 0.587116 | 0.231 |
| R-HSA-1268020 | Mitochondrial protein import | 0.592387 | 0.227 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.592387 | 0.227 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.592387 | 0.227 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.597591 | 0.224 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.597591 | 0.224 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.597591 | 0.224 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.597591 | 0.224 |
| R-HSA-8963743 | Digestion and absorption | 0.597591 | 0.224 |
| R-HSA-211981 | Xenobiotics | 0.602729 | 0.220 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.607801 | 0.216 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.610803 | 0.214 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.612809 | 0.213 |
| R-HSA-5663205 | Infectious disease | 0.613888 | 0.212 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.617754 | 0.209 |
| R-HSA-913709 | O-linked glycosylation of mucins | 0.622635 | 0.206 |
| R-HSA-167172 | Transcription of the HIV genome | 0.622635 | 0.206 |
| R-HSA-2187338 | Visual phototransduction | 0.624614 | 0.204 |
| R-HSA-1500931 | Cell-Cell communication | 0.625010 | 0.204 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.626947 | 0.203 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.627455 | 0.202 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.632213 | 0.199 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.634375 | 0.198 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.634375 | 0.198 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.636911 | 0.196 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.636911 | 0.196 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.636911 | 0.196 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 0.636911 | 0.196 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.636911 | 0.196 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.636911 | 0.196 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.641549 | 0.193 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.641549 | 0.193 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.646128 | 0.190 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.646128 | 0.190 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.646128 | 0.190 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.650204 | 0.187 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.650649 | 0.187 |
| R-HSA-380287 | Centrosome maturation | 0.655112 | 0.184 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.655112 | 0.184 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.655112 | 0.184 |
| R-HSA-9610379 | HCMV Late Events | 0.656382 | 0.183 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.659438 | 0.181 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.659519 | 0.181 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.663869 | 0.178 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.665486 | 0.177 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.668165 | 0.175 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.668165 | 0.175 |
| R-HSA-216083 | Integrin cell surface interactions | 0.668165 | 0.175 |
| R-HSA-109581 | Apoptosis | 0.671448 | 0.173 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.672405 | 0.172 |
| R-HSA-421270 | Cell-cell junction organization | 0.675305 | 0.171 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.676592 | 0.170 |
| R-HSA-6806834 | Signaling by MET | 0.676592 | 0.170 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.676592 | 0.170 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.677323 | 0.169 |
| R-HSA-977225 | Amyloid fiber formation | 0.680725 | 0.167 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.682303 | 0.166 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.684806 | 0.164 |
| R-HSA-5619102 | SLC transporter disorders | 0.685977 | 0.164 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.688835 | 0.162 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.692813 | 0.159 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.696740 | 0.157 |
| R-HSA-1500620 | Meiosis | 0.696740 | 0.157 |
| R-HSA-72306 | tRNA processing | 0.697219 | 0.157 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.700617 | 0.155 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.700617 | 0.155 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.703354 | 0.153 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.704445 | 0.152 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.704979 | 0.152 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.705431 | 0.152 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.705431 | 0.152 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.708224 | 0.150 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.708224 | 0.150 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.708224 | 0.150 |
| R-HSA-1266738 | Developmental Biology | 0.709088 | 0.149 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.710803 | 0.148 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.711955 | 0.148 |
| R-HSA-9663891 | Selective autophagy | 0.711955 | 0.148 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.715639 | 0.145 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.719275 | 0.143 |
| R-HSA-73884 | Base Excision Repair | 0.719275 | 0.143 |
| R-HSA-168255 | Influenza Infection | 0.721302 | 0.142 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.726410 | 0.139 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.727419 | 0.138 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.729910 | 0.137 |
| R-HSA-391251 | Protein folding | 0.729910 | 0.137 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.733365 | 0.135 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.733365 | 0.135 |
| R-HSA-422475 | Axon guidance | 0.733730 | 0.134 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.736776 | 0.133 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.737844 | 0.132 |
| R-HSA-69275 | G2/M Transition | 0.738906 | 0.131 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.741926 | 0.130 |
| R-HSA-9658195 | Leishmania infection | 0.741926 | 0.130 |
| R-HSA-2168880 | Scavenging of heme from plasma | 0.743468 | 0.129 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.743759 | 0.129 |
| R-HSA-983712 | Ion channel transport | 0.746157 | 0.127 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 0.746751 | 0.127 |
| R-HSA-1296071 | Potassium Channels | 0.746751 | 0.127 |
| R-HSA-5617833 | Cilium Assembly | 0.748535 | 0.126 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.749565 | 0.125 |
| R-HSA-157579 | Telomere Maintenance | 0.749991 | 0.125 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.749991 | 0.125 |
| R-HSA-168249 | Innate Immune System | 0.751172 | 0.124 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.753235 | 0.123 |
| R-HSA-68877 | Mitotic Prometaphase | 0.755556 | 0.122 |
| R-HSA-3214847 | HATs acetylate histones | 0.756349 | 0.121 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.761403 | 0.118 |
| R-HSA-913531 | Interferon Signaling | 0.761403 | 0.118 |
| R-HSA-9609690 | HCMV Early Events | 0.762409 | 0.118 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.762409 | 0.118 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.762546 | 0.118 |
| R-HSA-1643685 | Disease | 0.764988 | 0.116 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.765586 | 0.116 |
| R-HSA-1483255 | PI Metabolism | 0.765586 | 0.116 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.765586 | 0.116 |
| R-HSA-1483257 | Phospholipid metabolism | 0.769103 | 0.114 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.771549 | 0.113 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.777361 | 0.109 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.777755 | 0.109 |
| R-HSA-418346 | Platelet homeostasis | 0.780212 | 0.108 |
| R-HSA-69239 | Synthesis of DNA | 0.783026 | 0.106 |
| R-HSA-5357801 | Programmed Cell Death | 0.784064 | 0.106 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.785804 | 0.105 |
| R-HSA-9675108 | Nervous system development | 0.786388 | 0.104 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.788548 | 0.103 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.788548 | 0.103 |
| R-HSA-6803157 | Antimicrobial peptides | 0.793929 | 0.100 |
| R-HSA-68882 | Mitotic Anaphase | 0.805874 | 0.094 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.806795 | 0.093 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.807757 | 0.093 |
| R-HSA-1280218 | Adaptive Immune System | 0.809032 | 0.092 |
| R-HSA-418990 | Adherens junctions interactions | 0.809623 | 0.092 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.816477 | 0.088 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.818860 | 0.087 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.823474 | 0.084 |
| R-HSA-73886 | Chromosome Maintenance | 0.823474 | 0.084 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.823474 | 0.084 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.827971 | 0.082 |
| R-HSA-168256 | Immune System | 0.831807 | 0.080 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.834503 | 0.079 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.834503 | 0.079 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.834503 | 0.079 |
| R-HSA-114608 | Platelet degranulation | 0.838720 | 0.076 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.840788 | 0.075 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.842151 | 0.075 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.844846 | 0.073 |
| R-HSA-1474165 | Reproduction | 0.846836 | 0.072 |
| R-HSA-5576891 | Cardiac conduction | 0.848801 | 0.071 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.850740 | 0.070 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.852655 | 0.069 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.857179 | 0.067 |
| R-HSA-9609646 | HCMV Infection | 0.861427 | 0.065 |
| R-HSA-5173105 | O-linked glycosylation | 0.861868 | 0.065 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.865391 | 0.063 |
| R-HSA-6807070 | PTEN Regulation | 0.865391 | 0.063 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.873812 | 0.059 |
| R-HSA-69242 | S Phase | 0.881708 | 0.055 |
| R-HSA-166520 | Signaling by NTRKs | 0.881708 | 0.055 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.884582 | 0.053 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.884727 | 0.053 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.886208 | 0.052 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.887670 | 0.052 |
| R-HSA-9609507 | Protein localization | 0.889113 | 0.051 |
| R-HSA-69306 | DNA Replication | 0.889113 | 0.051 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.890537 | 0.050 |
| R-HSA-109582 | Hemostasis | 0.893632 | 0.049 |
| R-HSA-9711097 | Cellular response to starvation | 0.896056 | 0.048 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.900068 | 0.046 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 0.907481 | 0.042 |
| R-HSA-611105 | Respiratory electron transport | 0.920793 | 0.036 |
| R-HSA-5668914 | Diseases of metabolism | 0.927671 | 0.033 |
| R-HSA-375276 | Peptide ligand-binding receptors | 0.928591 | 0.032 |
| R-HSA-199991 | Membrane Trafficking | 0.932251 | 0.030 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 0.934784 | 0.029 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.935013 | 0.029 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.935624 | 0.029 |
| R-HSA-1474244 | Extracellular matrix organization | 0.940326 | 0.027 |
| R-HSA-428157 | Sphingolipid metabolism | 0.941210 | 0.026 |
| R-HSA-72172 | mRNA Splicing | 0.944183 | 0.025 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.944438 | 0.025 |
| R-HSA-397014 | Muscle contraction | 0.949686 | 0.022 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.949686 | 0.022 |
| R-HSA-112316 | Neuronal System | 0.950934 | 0.022 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.956600 | 0.019 |
| R-HSA-392499 | Metabolism of proteins | 0.957219 | 0.019 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.958196 | 0.019 |
| R-HSA-157118 | Signaling by NOTCH | 0.965029 | 0.015 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.971600 | 0.013 |
| R-HSA-416476 | G alpha (q) signalling events | 0.974409 | 0.011 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.978676 | 0.009 |
| R-HSA-8953854 | Metabolism of RNA | 0.986281 | 0.006 |
| R-HSA-8957322 | Metabolism of steroids | 0.988302 | 0.005 |
| R-HSA-382551 | Transport of small molecules | 0.989762 | 0.004 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.990634 | 0.004 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.995386 | 0.002 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.995564 | 0.002 |
| R-HSA-372790 | Signaling by GPCR | 0.996545 | 0.002 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.996806 | 0.001 |
| R-HSA-388396 | GPCR downstream signalling | 0.997972 | 0.001 |
| R-HSA-6798695 | Neutrophil degranulation | 0.997986 | 0.001 |
| R-HSA-211859 | Biological oxidations | 0.999158 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999179 | 0.000 |
| R-HSA-500792 | GPCR ligand binding | 0.999649 | 0.000 |
| R-HSA-9752946 | Expression and translocation of olfactory receptors | 0.999723 | 0.000 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.999761 | 0.000 |
| R-HSA-381753 | Olfactory Signaling Pathway | 0.999889 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999945 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
HIPK4 |
0.858 | 0.351 | 1 | 0.892 |
PRKD1 |
0.854 | 0.312 | -3 | 0.849 |
CLK3 |
0.849 | 0.280 | 1 | 0.852 |
PRKD2 |
0.846 | 0.225 | -3 | 0.811 |
SRPK1 |
0.845 | 0.235 | -3 | 0.767 |
CDK8 |
0.844 | 0.334 | 1 | 0.824 |
CDK19 |
0.843 | 0.337 | 1 | 0.804 |
KIS |
0.843 | 0.304 | 1 | 0.851 |
TSSK1 |
0.843 | 0.280 | -3 | 0.897 |
NDR2 |
0.842 | 0.077 | -3 | 0.855 |
COT |
0.841 | -0.018 | 2 | 0.804 |
CDK7 |
0.841 | 0.325 | 1 | 0.838 |
DYRK2 |
0.840 | 0.344 | 1 | 0.874 |
NLK |
0.840 | 0.263 | 1 | 0.891 |
NUAK2 |
0.839 | 0.176 | -3 | 0.865 |
MARK4 |
0.839 | 0.178 | 4 | 0.891 |
HIPK2 |
0.839 | 0.367 | 1 | 0.827 |
AMPKA1 |
0.838 | 0.186 | -3 | 0.881 |
AMPKA2 |
0.838 | 0.188 | -3 | 0.859 |
MTOR |
0.837 | 0.068 | 1 | 0.778 |
NUAK1 |
0.837 | 0.189 | -3 | 0.841 |
SRPK2 |
0.837 | 0.194 | -3 | 0.708 |
MAPKAPK3 |
0.836 | 0.140 | -3 | 0.827 |
TSSK2 |
0.836 | 0.254 | -5 | 0.830 |
PIM3 |
0.836 | 0.054 | -3 | 0.848 |
CDC7 |
0.835 | -0.010 | 1 | 0.720 |
ICK |
0.835 | 0.205 | -3 | 0.848 |
CAMK1B |
0.834 | 0.111 | -3 | 0.879 |
CAMK2D |
0.834 | 0.130 | -3 | 0.873 |
CDKL1 |
0.834 | 0.119 | -3 | 0.818 |
CDKL5 |
0.833 | 0.124 | -3 | 0.818 |
JNK2 |
0.833 | 0.365 | 1 | 0.809 |
LATS2 |
0.832 | 0.050 | -5 | 0.649 |
CDK13 |
0.832 | 0.310 | 1 | 0.825 |
PKN3 |
0.832 | 0.067 | -3 | 0.856 |
PRKD3 |
0.832 | 0.200 | -3 | 0.783 |
QSK |
0.831 | 0.187 | 4 | 0.874 |
CLK1 |
0.831 | 0.248 | -3 | 0.787 |
PRPK |
0.831 | -0.099 | -1 | 0.864 |
PDHK4 |
0.831 | -0.089 | 1 | 0.787 |
CDK18 |
0.831 | 0.335 | 1 | 0.795 |
HIPK1 |
0.831 | 0.332 | 1 | 0.880 |
CDK9 |
0.831 | 0.312 | 1 | 0.832 |
CDK5 |
0.830 | 0.308 | 1 | 0.846 |
SIK |
0.830 | 0.184 | -3 | 0.804 |
MAPKAPK2 |
0.830 | 0.127 | -3 | 0.776 |
ATR |
0.830 | 0.052 | 1 | 0.801 |
ERK5 |
0.830 | 0.119 | 1 | 0.815 |
NDR1 |
0.829 | 0.018 | -3 | 0.861 |
MOS |
0.829 | -0.006 | 1 | 0.768 |
TBK1 |
0.829 | -0.065 | 1 | 0.674 |
P90RSK |
0.829 | 0.073 | -3 | 0.805 |
PIM1 |
0.828 | 0.106 | -3 | 0.809 |
CHK1 |
0.828 | 0.237 | -3 | 0.879 |
MELK |
0.828 | 0.134 | -3 | 0.856 |
GCN2 |
0.828 | -0.136 | 2 | 0.749 |
PDHK1 |
0.828 | -0.064 | 1 | 0.776 |
CLK4 |
0.828 | 0.211 | -3 | 0.800 |
RSK2 |
0.828 | 0.067 | -3 | 0.804 |
DYRK1A |
0.828 | 0.289 | 1 | 0.874 |
ULK2 |
0.828 | -0.118 | 2 | 0.758 |
RAF1 |
0.827 | -0.095 | 1 | 0.758 |
CDK12 |
0.827 | 0.311 | 1 | 0.811 |
NIK |
0.826 | 0.061 | -3 | 0.890 |
HIPK3 |
0.826 | 0.319 | 1 | 0.871 |
CLK2 |
0.825 | 0.247 | -3 | 0.785 |
SKMLCK |
0.825 | 0.049 | -2 | 0.802 |
PKCD |
0.825 | 0.049 | 2 | 0.737 |
WNK1 |
0.825 | 0.028 | -2 | 0.819 |
JNK3 |
0.825 | 0.331 | 1 | 0.825 |
TGFBR2 |
0.825 | -0.022 | -2 | 0.749 |
CDK17 |
0.824 | 0.322 | 1 | 0.756 |
BMPR2 |
0.824 | -0.132 | -2 | 0.836 |
P38A |
0.824 | 0.316 | 1 | 0.847 |
CDK1 |
0.824 | 0.297 | 1 | 0.807 |
RSK3 |
0.824 | 0.037 | -3 | 0.801 |
P38G |
0.824 | 0.331 | 1 | 0.753 |
DYRK1B |
0.824 | 0.314 | 1 | 0.833 |
CAMK2B |
0.823 | 0.118 | 2 | 0.732 |
MST4 |
0.823 | 0.023 | 2 | 0.818 |
LATS1 |
0.823 | 0.117 | -3 | 0.862 |
BRSK2 |
0.823 | 0.087 | -3 | 0.863 |
MARK3 |
0.823 | 0.173 | 4 | 0.855 |
DYRK4 |
0.823 | 0.323 | 1 | 0.825 |
IKKE |
0.823 | -0.100 | 1 | 0.671 |
SRPK3 |
0.823 | 0.151 | -3 | 0.737 |
MARK2 |
0.822 | 0.169 | 4 | 0.830 |
P38B |
0.822 | 0.325 | 1 | 0.802 |
NEK6 |
0.822 | -0.053 | -2 | 0.820 |
NIM1 |
0.822 | 0.029 | 3 | 0.759 |
CAMK2G |
0.822 | -0.068 | 2 | 0.753 |
CAMLCK |
0.822 | 0.024 | -2 | 0.795 |
DAPK2 |
0.822 | 0.049 | -3 | 0.882 |
AURC |
0.822 | 0.052 | -2 | 0.597 |
MNK2 |
0.822 | 0.064 | -2 | 0.751 |
IKKB |
0.822 | -0.148 | -2 | 0.688 |
ERK1 |
0.822 | 0.302 | 1 | 0.805 |
CAMK2A |
0.822 | 0.114 | 2 | 0.727 |
QIK |
0.821 | 0.101 | -3 | 0.865 |
PKACG |
0.821 | 0.021 | -2 | 0.676 |
PKN2 |
0.821 | 0.025 | -3 | 0.862 |
CHAK2 |
0.820 | -0.023 | -1 | 0.856 |
CAMK4 |
0.820 | 0.044 | -3 | 0.859 |
BRSK1 |
0.820 | 0.075 | -3 | 0.833 |
DSTYK |
0.819 | -0.133 | 2 | 0.812 |
DYRK3 |
0.818 | 0.259 | 1 | 0.883 |
FAM20C |
0.818 | 0.137 | 2 | 0.663 |
NEK9 |
0.818 | -0.083 | 2 | 0.793 |
PHKG1 |
0.818 | 0.029 | -3 | 0.855 |
BCKDK |
0.818 | -0.096 | -1 | 0.862 |
MASTL |
0.817 | -0.136 | -2 | 0.770 |
ATM |
0.817 | 0.049 | 1 | 0.752 |
HUNK |
0.817 | -0.102 | 2 | 0.744 |
IKKA |
0.817 | -0.065 | -2 | 0.686 |
NEK7 |
0.816 | -0.154 | -3 | 0.813 |
RIPK3 |
0.816 | -0.117 | 3 | 0.717 |
DNAPK |
0.816 | 0.107 | 1 | 0.741 |
P38D |
0.816 | 0.332 | 1 | 0.785 |
MLK2 |
0.816 | -0.067 | 2 | 0.783 |
PKCB |
0.816 | 0.022 | 2 | 0.680 |
ULK1 |
0.816 | -0.157 | -3 | 0.803 |
CDK3 |
0.816 | 0.276 | 1 | 0.769 |
P70S6KB |
0.816 | 0.001 | -3 | 0.836 |
CDK10 |
0.815 | 0.296 | 1 | 0.822 |
WNK3 |
0.815 | -0.155 | 1 | 0.753 |
ERK2 |
0.815 | 0.273 | 1 | 0.830 |
CDK14 |
0.815 | 0.302 | 1 | 0.827 |
MARK1 |
0.815 | 0.125 | 4 | 0.863 |
RIPK1 |
0.814 | -0.078 | 1 | 0.765 |
CDK16 |
0.814 | 0.311 | 1 | 0.767 |
MNK1 |
0.814 | 0.049 | -2 | 0.765 |
PKACB |
0.814 | 0.066 | -2 | 0.617 |
MSK2 |
0.813 | 0.021 | -3 | 0.766 |
PKCA |
0.813 | 0.013 | 2 | 0.678 |
PAK3 |
0.813 | -0.037 | -2 | 0.736 |
DCAMKL1 |
0.813 | 0.091 | -3 | 0.823 |
PAK1 |
0.812 | -0.021 | -2 | 0.731 |
IRE1 |
0.812 | -0.060 | 1 | 0.753 |
PKCZ |
0.812 | -0.003 | 2 | 0.729 |
SSTK |
0.812 | 0.129 | 4 | 0.858 |
AURB |
0.812 | 0.023 | -2 | 0.593 |
CDK2 |
0.811 | 0.187 | 1 | 0.836 |
GRK5 |
0.811 | -0.188 | -3 | 0.818 |
MLK1 |
0.810 | -0.185 | 2 | 0.758 |
MSK1 |
0.810 | 0.043 | -3 | 0.784 |
RSK4 |
0.810 | 0.039 | -3 | 0.774 |
NEK2 |
0.810 | -0.047 | 2 | 0.770 |
CAMK1D |
0.809 | 0.133 | -3 | 0.755 |
SGK3 |
0.809 | 0.052 | -3 | 0.809 |
PKCG |
0.809 | -0.025 | 2 | 0.671 |
PKR |
0.809 | -0.010 | 1 | 0.791 |
CAMK1G |
0.809 | 0.079 | -3 | 0.803 |
AKT2 |
0.808 | 0.070 | -3 | 0.732 |
ANKRD3 |
0.808 | -0.143 | 1 | 0.789 |
PKG2 |
0.808 | 0.022 | -2 | 0.615 |
MOK |
0.808 | 0.263 | 1 | 0.868 |
IRE2 |
0.807 | -0.066 | 2 | 0.708 |
PRKX |
0.807 | 0.083 | -3 | 0.728 |
PKCH |
0.807 | -0.022 | 2 | 0.670 |
PAK6 |
0.807 | 0.016 | -2 | 0.652 |
SMG1 |
0.807 | 0.004 | 1 | 0.771 |
VRK2 |
0.807 | -0.043 | 1 | 0.821 |
PLK1 |
0.807 | -0.068 | -2 | 0.792 |
DLK |
0.807 | -0.187 | 1 | 0.734 |
PIM2 |
0.806 | 0.049 | -3 | 0.793 |
MAPKAPK5 |
0.806 | 0.010 | -3 | 0.770 |
CHAK1 |
0.806 | -0.091 | 2 | 0.757 |
MAK |
0.806 | 0.257 | -2 | 0.699 |
MLK3 |
0.806 | -0.088 | 2 | 0.687 |
CDK4 |
0.805 | 0.293 | 1 | 0.804 |
ALK4 |
0.805 | -0.055 | -2 | 0.772 |
TGFBR1 |
0.803 | -0.024 | -2 | 0.745 |
CDK6 |
0.803 | 0.275 | 1 | 0.817 |
PRP4 |
0.802 | 0.138 | -3 | 0.715 |
DCAMKL2 |
0.802 | 0.049 | -3 | 0.850 |
TLK2 |
0.802 | -0.058 | 1 | 0.746 |
PAK2 |
0.802 | -0.065 | -2 | 0.711 |
MEK1 |
0.802 | -0.125 | 2 | 0.806 |
GRK6 |
0.802 | -0.144 | 1 | 0.720 |
YSK4 |
0.802 | -0.123 | 1 | 0.693 |
GRK1 |
0.802 | -0.098 | -2 | 0.695 |
MYLK4 |
0.801 | 0.004 | -2 | 0.710 |
SNRK |
0.801 | -0.100 | 2 | 0.643 |
BUB1 |
0.801 | 0.273 | -5 | 0.819 |
PKACA |
0.800 | 0.051 | -2 | 0.567 |
AKT1 |
0.800 | 0.060 | -3 | 0.755 |
PERK |
0.800 | -0.075 | -2 | 0.776 |
MPSK1 |
0.800 | 0.074 | 1 | 0.754 |
WNK4 |
0.799 | -0.038 | -2 | 0.811 |
PHKG2 |
0.799 | 0.002 | -3 | 0.840 |
PKCT |
0.799 | -0.009 | 2 | 0.685 |
HRI |
0.799 | -0.088 | -2 | 0.810 |
SBK |
0.799 | 0.158 | -3 | 0.627 |
PLK3 |
0.799 | -0.071 | 2 | 0.708 |
PINK1 |
0.798 | -0.036 | 1 | 0.840 |
CAMK1A |
0.798 | 0.145 | -3 | 0.699 |
NEK5 |
0.797 | -0.049 | 1 | 0.766 |
GRK4 |
0.797 | -0.216 | -2 | 0.753 |
BMPR1B |
0.797 | -0.040 | 1 | 0.653 |
PLK4 |
0.796 | -0.098 | 2 | 0.598 |
GSK3A |
0.796 | 0.112 | 4 | 0.502 |
TTBK2 |
0.796 | -0.243 | 2 | 0.659 |
AURA |
0.796 | -0.017 | -2 | 0.568 |
IRAK4 |
0.795 | -0.083 | 1 | 0.753 |
PKCI |
0.795 | -0.007 | 2 | 0.696 |
P70S6K |
0.795 | -0.004 | -3 | 0.762 |
GRK7 |
0.795 | -0.032 | 1 | 0.674 |
JNK1 |
0.795 | 0.256 | 1 | 0.790 |
MLK4 |
0.795 | -0.156 | 2 | 0.675 |
BRAF |
0.795 | -0.092 | -4 | 0.796 |
ACVR2A |
0.794 | -0.067 | -2 | 0.750 |
SMMLCK |
0.794 | 0.004 | -3 | 0.847 |
PKN1 |
0.794 | 0.054 | -3 | 0.779 |
ALK2 |
0.793 | -0.061 | -2 | 0.737 |
GSK3B |
0.793 | 0.049 | 4 | 0.495 |
CHK2 |
0.793 | 0.104 | -3 | 0.688 |
MEKK1 |
0.792 | -0.157 | 1 | 0.743 |
ACVR2B |
0.792 | -0.082 | -2 | 0.759 |
MEK5 |
0.791 | -0.199 | 2 | 0.790 |
ERK7 |
0.791 | 0.054 | 2 | 0.469 |
PAK5 |
0.791 | -0.023 | -2 | 0.588 |
LKB1 |
0.790 | -0.024 | -3 | 0.838 |
TAO3 |
0.790 | -0.040 | 1 | 0.729 |
TLK1 |
0.790 | -0.091 | -2 | 0.780 |
SGK1 |
0.789 | 0.072 | -3 | 0.660 |
ZAK |
0.788 | -0.168 | 1 | 0.698 |
MEKK2 |
0.788 | -0.151 | 2 | 0.767 |
PKCE |
0.788 | 0.007 | 2 | 0.661 |
MST3 |
0.787 | -0.079 | 2 | 0.771 |
DRAK1 |
0.787 | -0.144 | 1 | 0.672 |
MRCKA |
0.786 | 0.044 | -3 | 0.807 |
AKT3 |
0.786 | 0.050 | -3 | 0.667 |
ROCK2 |
0.785 | 0.058 | -3 | 0.831 |
PDK1 |
0.785 | -0.036 | 1 | 0.754 |
PAK4 |
0.784 | -0.032 | -2 | 0.595 |
HGK |
0.784 | -0.018 | 3 | 0.853 |
PASK |
0.784 | -0.029 | -3 | 0.844 |
GCK |
0.784 | -0.011 | 1 | 0.735 |
TNIK |
0.784 | 0.004 | 3 | 0.855 |
DAPK3 |
0.784 | 0.019 | -3 | 0.827 |
MRCKB |
0.783 | 0.035 | -3 | 0.789 |
TAO2 |
0.783 | -0.082 | 2 | 0.795 |
NEK4 |
0.783 | -0.087 | 1 | 0.742 |
NEK1 |
0.783 | -0.014 | 1 | 0.742 |
KHS1 |
0.783 | 0.048 | 1 | 0.734 |
GAK |
0.782 | -0.022 | 1 | 0.769 |
MEKK6 |
0.782 | -0.067 | 1 | 0.712 |
MEKK3 |
0.782 | -0.243 | 1 | 0.726 |
LOK |
0.782 | -0.041 | -2 | 0.738 |
IRAK1 |
0.782 | -0.189 | -1 | 0.777 |
BMPR1A |
0.781 | -0.052 | 1 | 0.629 |
PBK |
0.781 | 0.033 | 1 | 0.701 |
NEK11 |
0.780 | -0.162 | 1 | 0.734 |
CAMKK2 |
0.780 | -0.147 | -2 | 0.681 |
LRRK2 |
0.780 | -0.059 | 2 | 0.791 |
MINK |
0.780 | -0.045 | 1 | 0.728 |
MST2 |
0.779 | -0.086 | 1 | 0.727 |
NEK8 |
0.779 | -0.193 | 2 | 0.763 |
MAP3K15 |
0.779 | -0.071 | 1 | 0.695 |
HPK1 |
0.779 | -0.022 | 1 | 0.734 |
KHS2 |
0.778 | 0.035 | 1 | 0.749 |
GRK2 |
0.778 | -0.158 | -2 | 0.630 |
CAMKK1 |
0.777 | -0.213 | -2 | 0.685 |
PKG1 |
0.777 | 0.004 | -2 | 0.542 |
DAPK1 |
0.774 | -0.004 | -3 | 0.806 |
NEK3 |
0.774 | -0.063 | 1 | 0.706 |
EEF2K |
0.773 | -0.094 | 3 | 0.813 |
CRIK |
0.773 | 0.059 | -3 | 0.748 |
SLK |
0.773 | -0.073 | -2 | 0.676 |
DMPK1 |
0.773 | 0.063 | -3 | 0.795 |
VRK1 |
0.772 | -0.135 | 2 | 0.772 |
YSK1 |
0.772 | -0.076 | 2 | 0.768 |
CK1E |
0.772 | -0.123 | -3 | 0.443 |
MST1 |
0.772 | -0.094 | 1 | 0.719 |
ROCK1 |
0.771 | 0.033 | -3 | 0.805 |
PDHK3_TYR |
0.771 | 0.151 | 4 | 0.878 |
TTBK1 |
0.769 | -0.220 | 2 | 0.582 |
CK1G1 |
0.769 | -0.128 | -3 | 0.428 |
MEK2 |
0.769 | -0.186 | 2 | 0.789 |
TAK1 |
0.769 | -0.172 | 1 | 0.743 |
STK33 |
0.766 | -0.161 | 2 | 0.576 |
PLK2 |
0.766 | -0.075 | -3 | 0.743 |
LIMK2_TYR |
0.766 | 0.104 | -3 | 0.902 |
CK2A2 |
0.766 | -0.033 | 1 | 0.567 |
RIPK2 |
0.764 | -0.224 | 1 | 0.668 |
BIKE |
0.764 | 0.035 | 1 | 0.673 |
HASPIN |
0.764 | -0.006 | -1 | 0.702 |
CK1D |
0.764 | -0.111 | -3 | 0.390 |
TESK1_TYR |
0.763 | -0.012 | 3 | 0.870 |
MYO3B |
0.762 | -0.036 | 2 | 0.785 |
PKMYT1_TYR |
0.762 | 0.028 | 3 | 0.835 |
TTK |
0.761 | -0.067 | -2 | 0.786 |
MAP2K4_TYR |
0.760 | -0.032 | -1 | 0.890 |
PDHK4_TYR |
0.760 | -0.007 | 2 | 0.824 |
GRK3 |
0.759 | -0.163 | -2 | 0.577 |
CK1A2 |
0.758 | -0.125 | -3 | 0.393 |
OSR1 |
0.757 | -0.114 | 2 | 0.777 |
AAK1 |
0.757 | 0.086 | 1 | 0.594 |
TAO1 |
0.757 | -0.084 | 1 | 0.672 |
MAP2K7_TYR |
0.756 | -0.164 | 2 | 0.810 |
MAP2K6_TYR |
0.755 | -0.085 | -1 | 0.891 |
MYO3A |
0.755 | -0.082 | 1 | 0.748 |
CK2A1 |
0.754 | -0.050 | 1 | 0.547 |
LIMK1_TYR |
0.754 | -0.056 | 2 | 0.818 |
ASK1 |
0.753 | -0.137 | 1 | 0.679 |
BMPR2_TYR |
0.750 | -0.089 | -1 | 0.854 |
TNNI3K_TYR |
0.750 | 0.032 | 1 | 0.747 |
PINK1_TYR |
0.750 | -0.221 | 1 | 0.762 |
PDHK1_TYR |
0.750 | -0.125 | -1 | 0.886 |
RET |
0.750 | -0.120 | 1 | 0.740 |
TYK2 |
0.748 | -0.136 | 1 | 0.730 |
ROS1 |
0.747 | -0.114 | 3 | 0.765 |
NEK10_TYR |
0.746 | -0.036 | 1 | 0.635 |
JAK2 |
0.745 | -0.125 | 1 | 0.730 |
DDR1 |
0.745 | -0.136 | 4 | 0.812 |
TNK1 |
0.744 | -0.043 | 3 | 0.769 |
MST1R |
0.744 | -0.140 | 3 | 0.781 |
TYRO3 |
0.742 | -0.185 | 3 | 0.786 |
ALPHAK3 |
0.742 | -0.137 | -1 | 0.753 |
EPHB4 |
0.740 | -0.119 | -1 | 0.824 |
STLK3 |
0.740 | -0.179 | 1 | 0.671 |
CSF1R |
0.740 | -0.145 | 3 | 0.768 |
ABL2 |
0.739 | -0.095 | -1 | 0.780 |
EPHA6 |
0.739 | -0.141 | -1 | 0.825 |
JAK1 |
0.738 | -0.051 | 1 | 0.680 |
JAK3 |
0.737 | -0.150 | 1 | 0.704 |
DDR2 |
0.737 | -0.008 | 3 | 0.688 |
TNK2 |
0.736 | -0.124 | 3 | 0.707 |
FGR |
0.736 | -0.160 | 1 | 0.729 |
YES1 |
0.735 | -0.135 | -1 | 0.832 |
ABL1 |
0.733 | -0.117 | -1 | 0.775 |
YANK3 |
0.733 | -0.124 | 2 | 0.363 |
INSRR |
0.733 | -0.167 | 3 | 0.716 |
PDGFRB |
0.731 | -0.218 | 3 | 0.781 |
FGFR1 |
0.730 | -0.150 | 3 | 0.733 |
TXK |
0.730 | -0.116 | 1 | 0.679 |
FER |
0.730 | -0.232 | 1 | 0.733 |
FGFR2 |
0.730 | -0.185 | 3 | 0.751 |
TEK |
0.729 | -0.171 | 3 | 0.707 |
EPHA4 |
0.729 | -0.130 | 2 | 0.701 |
HCK |
0.729 | -0.170 | -1 | 0.790 |
ITK |
0.728 | -0.167 | -1 | 0.768 |
AXL |
0.728 | -0.186 | 3 | 0.746 |
PDGFRA |
0.728 | -0.214 | 3 | 0.781 |
EPHB3 |
0.727 | -0.163 | -1 | 0.803 |
EPHB1 |
0.727 | -0.183 | 1 | 0.704 |
LCK |
0.727 | -0.127 | -1 | 0.783 |
SRMS |
0.726 | -0.203 | 1 | 0.704 |
FLT3 |
0.725 | -0.236 | 3 | 0.776 |
WEE1_TYR |
0.725 | -0.116 | -1 | 0.740 |
EPHB2 |
0.725 | -0.153 | -1 | 0.796 |
CK1A |
0.725 | -0.143 | -3 | 0.292 |
BLK |
0.725 | -0.110 | -1 | 0.791 |
KDR |
0.724 | -0.202 | 3 | 0.724 |
KIT |
0.724 | -0.219 | 3 | 0.762 |
ALK |
0.722 | -0.203 | 3 | 0.689 |
MERTK |
0.720 | -0.207 | 3 | 0.747 |
PTK6 |
0.720 | -0.230 | -1 | 0.703 |
NTRK1 |
0.719 | -0.239 | -1 | 0.823 |
BTK |
0.718 | -0.274 | -1 | 0.736 |
BMX |
0.718 | -0.160 | -1 | 0.666 |
LTK |
0.718 | -0.218 | 3 | 0.710 |
MET |
0.717 | -0.220 | 3 | 0.750 |
EPHA1 |
0.717 | -0.192 | 3 | 0.726 |
NTRK2 |
0.716 | -0.248 | 3 | 0.723 |
INSR |
0.716 | -0.201 | 3 | 0.696 |
TEC |
0.716 | -0.211 | -1 | 0.701 |
EPHA7 |
0.715 | -0.183 | 2 | 0.710 |
EPHA3 |
0.714 | -0.201 | 2 | 0.679 |
FLT4 |
0.713 | -0.236 | 3 | 0.721 |
FYN |
0.713 | -0.137 | -1 | 0.756 |
FGFR3 |
0.713 | -0.231 | 3 | 0.715 |
PTK2B |
0.712 | -0.150 | -1 | 0.754 |
NTRK3 |
0.712 | -0.201 | -1 | 0.767 |
FLT1 |
0.711 | -0.246 | -1 | 0.804 |
ERBB2 |
0.710 | -0.262 | 1 | 0.662 |
FRK |
0.710 | -0.224 | -1 | 0.784 |
LYN |
0.709 | -0.202 | 3 | 0.698 |
EPHA5 |
0.707 | -0.181 | 2 | 0.688 |
CSK |
0.705 | -0.210 | 2 | 0.715 |
SRC |
0.704 | -0.186 | -1 | 0.763 |
EPHA8 |
0.702 | -0.202 | -1 | 0.759 |
MATK |
0.702 | -0.223 | -1 | 0.707 |
EGFR |
0.702 | -0.174 | 1 | 0.564 |
CK1G3 |
0.699 | -0.163 | -3 | 0.242 |
MUSK |
0.698 | -0.205 | 1 | 0.561 |
PTK2 |
0.698 | -0.123 | -1 | 0.748 |
FGFR4 |
0.697 | -0.206 | -1 | 0.746 |
IGF1R |
0.696 | -0.217 | 3 | 0.635 |
YANK2 |
0.694 | -0.165 | 2 | 0.384 |
EPHA2 |
0.692 | -0.198 | -1 | 0.726 |
SYK |
0.690 | -0.174 | -1 | 0.723 |
ERBB4 |
0.683 | -0.184 | 1 | 0.570 |
FES |
0.672 | -0.265 | -1 | 0.653 |
ZAP70 |
0.668 | -0.175 | -1 | 0.653 |
CK1G2 |
0.668 | -0.194 | -3 | 0.341 |