Motif 829 (n=145)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0FGR8 | ESYT2 | S821 | ochoa | Extended synaptotagmin-2 (E-Syt2) (Chr2Syt) | Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex. Promotes the localization of SACM1L at endoplasmic reticulum-plasma membrane contact sites (EPCS) (PubMed:27044890). {ECO:0000269|PubMed:17360437, ECO:0000269|PubMed:20833364, ECO:0000269|PubMed:23791178, ECO:0000269|PubMed:24847877, ECO:0000269|PubMed:27044890}. |
| D6RIA3 | C4orf54 | S687 | ochoa | Uncharacterized protein C4orf54 (Familial obliterative portal venopathy) | None |
| H0YC42 | None | S159 | ochoa | Tumor protein D52 | None |
| K7EQG2 | None | S85 | ochoa | Uncharacterized protein | None |
| O00515 | LAD1 | S251 | ochoa | Ladinin-1 (Lad-1) (Linear IgA disease antigen) (LADA) | Anchoring filament protein which is a component of the basement membrane zone. {ECO:0000250}. |
| O14617 | AP3D1 | S1070 | ochoa | AP-3 complex subunit delta-1 (AP-3 complex subunit delta) (Adaptor-related protein complex 3 subunit delta-1) (Delta-adaptin) | Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Involved in process of CD8+ T-cell and NK cell degranulation (PubMed:26744459). In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity). {ECO:0000250|UniProtKB:O54774, ECO:0000269|PubMed:26744459}. |
| O15438 | ABCC3 | S281 | ochoa | ATP-binding cassette sub-family C member 3 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (Canalicular multispecific organic anion transporter 2) (Multi-specific organic anion transporter D) (MOAT-D) (Multidrug resistance-associated protein 3) | ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes (PubMed:10359813, PubMed:11581266, PubMed:15083066). Transports glucuronide conjugates such as bilirubin diglucuronide, estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4) (PubMed:11581266, PubMed:15083066). Transports also various bile salts (taurocholate, glycocholate, taurochenodeoxycholate-3-sulfate, taurolithocholate- 3-sulfate) (By similarity). Does not contribute substantially to bile salt physiology but provides an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Can confer resistance to various anticancer drugs, methotrexate, tenoposide and etoposide, by decreasing accumulation of these drugs in cells (PubMed:10359813, PubMed:11581266). {ECO:0000250|UniProtKB:O88563, ECO:0000269|PubMed:10359813, ECO:0000269|PubMed:11581266, ECO:0000269|PubMed:15083066, ECO:0000305|PubMed:35307651}. |
| O43399 | TPD52L2 | S149 | ochoa | Tumor protein D54 (hD54) (Tumor protein D52-like 2) | None |
| O43707 | ACTN4 | S191 | ochoa | Alpha-actinin-4 (Non-muscle alpha-actinin 4) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:22351778, ECO:0000269|PubMed:22689882, ECO:0000305|PubMed:9508771}. |
| O75683 | SURF6 | S22 | ochoa | Surfeit locus protein 6 | Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly (By similarity). {ECO:0000250}. |
| O94806 | PRKD3 | S539 | ochoa | Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (Protein kinase EPK2) (nPKC-nu) | Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity). {ECO:0000250}. |
| O94966 | USP19 | S62 | ochoa | Ubiquitin carboxyl-terminal hydrolase 19 (EC 3.4.19.12) (Deubiquitinating enzyme 19) (Ubiquitin thioesterase 19) (Ubiquitin-specific-processing protease 19) (Zinc finger MYND domain-containing protein 9) | Deubiquitinating enzyme that regulates the degradation of various proteins by removing ubiquitin moieties, thereby preventing their proteasomal degradation. Stabilizes RNF123, which promotes CDKN1B degradation and contributes to cell proliferation (By similarity). Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates (PubMed:19465887, PubMed:24356957). Mechanistically, deubiquitinates and thereby stabilizes several E3 ligases involved in the ERAD pathway including SYVN1 or MARCHF6 (PubMed:24356957). Regulates the stability of other E3 ligases including BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination (PubMed:21849505). Required for cells to mount an appropriate response to hypoxia by rescuing HIF1A from degradation in a non-catalytic manner and by mediating the deubiquitination of FUNDC1 (PubMed:22128162, PubMed:33978709). Attenuates mitochondrial damage and ferroptosis by targeting and stabilizing NADPH oxidase 4/NOX4 (PubMed:38943386). Negatively regulates TNF-alpha- and IL-1beta-triggered NF-kappa-B activation by hydrolyzing 'Lys-27'- and 'Lys-63'-linked polyubiquitin chains from MAP3K7 (PubMed:31127032). Modulates also the protein level and aggregation of polyQ-expanded huntingtin/HTT through HSP90AA1 (PubMed:33094816). {ECO:0000250|UniProtKB:Q3UJD6, ECO:0000250|UniProtKB:Q6J1Y9, ECO:0000269|PubMed:19465887, ECO:0000269|PubMed:21849505, ECO:0000269|PubMed:22128162, ECO:0000269|PubMed:22689415, ECO:0000269|PubMed:24356957, ECO:0000269|PubMed:31127032, ECO:0000269|PubMed:33094816, ECO:0000269|PubMed:33978709, ECO:0000269|PubMed:38943386}. |
| P01275 | GCG | S150 | ochoa | Pro-glucagon [Cleaved into: Glicentin; Glicentin-related polypeptide (GRPP); Oxyntomodulin (OXM) (OXY); Glucagon; Glucagon-like peptide 1 (GLP-1) (Incretin hormone); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)] | [Glucagon]: Plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes. {ECO:0000305|PubMed:10605628, ECO:0000305|PubMed:12626323}.; FUNCTION: [Glucagon-like peptide 1]: Potent stimulator of glucose-dependent insulin release. Also stimulates insulin release in response to IL6 (PubMed:22037645). Plays important roles on gastric motility and the suppression of plasma glucagon levels. May be involved in the suppression of satiety and stimulation of glucose disposal in peripheral tissues, independent of the actions of insulin. Has growth-promoting activities on intestinal epithelium. May also regulate the hypothalamic pituitary axis (HPA) via effects on LH, TSH, CRH, oxytocin, and vasopressin secretion. Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferation. Inhibits beta cell apoptosis (Probable). {ECO:0000269|PubMed:22037645, ECO:0000305|PubMed:10605628, ECO:0000305|PubMed:12554744, ECO:0000305|PubMed:14719035}.; FUNCTION: [Glucagon-like peptide 2]: Stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a key role in nutrient homeostasis, enhancing nutrient assimilation through enhanced gastrointestinal function, as well as increasing nutrient disposal. Stimulates intestinal glucose transport and decreases mucosal permeability. {ECO:0000305|PubMed:10322410, ECO:0000305|PubMed:10605628, ECO:0000305|PubMed:12554744, ECO:0000305|PubMed:14719035}.; FUNCTION: [Oxyntomodulin]: Significantly reduces food intake. Inhibits gastric emptying in humans. Suppression of gastric emptying may lead to increased gastric distension, which may contribute to satiety by causing a sensation of fullness. {ECO:0000305|PubMed:10605628, ECO:0000305|PubMed:12554744}.; FUNCTION: [Glicentin]: May modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life. {ECO:0000305|PubMed:10605628, ECO:0000305|PubMed:12554744}. |
| P04049 | RAF1 | S359 | psp | RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) | Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}. |
| P04626 | ERBB2 | S1083 | ochoa | Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340) | Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. {ECO:0000305}.; FUNCTION: In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. {ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:15380516, ECO:0000269|PubMed:21555369}. |
| P06239 | LCK | S150 | ochoa | Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK) | Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules are recruited, ultimately leading to lymphokine production. LCK also contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, which leads to hyperphosphorylation and activation of LCK. Also plays a role in the IL2 receptor-linked signaling pathway that controls the T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Phosphorylates other substrates including RUNX3, PTK2B/PYK2, the microtubule-associated protein MAPT, RHOH or TYROBP. Interacts with FYB2 (PubMed:27335501). {ECO:0000269|PubMed:16339550, ECO:0000269|PubMed:16709819, ECO:0000269|PubMed:20028775, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:20851766, ECO:0000269|PubMed:21269457, ECO:0000269|PubMed:22080863, ECO:0000269|PubMed:27335501, ECO:0000269|PubMed:38614099}. |
| P09661 | SNRPA1 | S178 | ochoa | U2 small nuclear ribonucleoprotein A' (U2 snRNP A') | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:27035939, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:32494006). Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA (PubMed:27035939, PubMed:32494006, PubMed:9716128). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:27035939, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:9716128}. |
| P11233 | RALA | S22 | ochoa | Ras-related protein Ral-A (EC 3.6.5.2) | Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors (PubMed:18756269, PubMed:19306925, PubMed:20005108, PubMed:21822277, PubMed:30500825). Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling (PubMed:20005108). Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells (PubMed:19306925). During mitosis, supports the stabilization and elongation of the intracellular bridge between dividing cells. Cooperates with EXOC2 to recruit other components of the exocyst to the early midbody (PubMed:18756269). During mitosis, also controls mitochondrial fission by recruiting to the mitochondrion RALBP1, which mediates the phosphorylation and activation of DNM1L by the mitotic kinase cyclin B-CDK1 (PubMed:21822277). {ECO:0000269|PubMed:18756269, ECO:0000269|PubMed:19306925, ECO:0000269|PubMed:20005108, ECO:0000269|PubMed:21822277, ECO:0000269|PubMed:30500825}. |
| P11234 | RALB | S22 | ochoa | Ras-related protein Ral-B (EC 3.6.5.2) | Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking (PubMed:10393179, PubMed:17875936, PubMed:18756269). Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles (By similarity). Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells (By similarity). Required for suppression of apoptosis (PubMed:17875936). In late stages of cytokinesis, upon completion of the bridge formation between dividing cells, mediates exocyst recruitment to the midbody to drive abscission (PubMed:18756269). Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors (PubMed:10393179). {ECO:0000250|UniProtKB:P36860, ECO:0000269|PubMed:10393179, ECO:0000269|PubMed:17875936, ECO:0000269|PubMed:18756269}. |
| P12268 | IMPDH2 | S416 | ochoa | Inosine-5'-monophosphate dehydrogenase 2 (IMP dehydrogenase 2) (IMPD 2) (IMPDH 2) (EC 1.1.1.205) (Inosine-5'-monophosphate dehydrogenase type II) (IMP dehydrogenase II) (IMPDH-II) | Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (PubMed:7763314, PubMed:7903306). Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism (PubMed:14766016). It may also have a role in the development of malignancy and the growth progression of some tumors. {ECO:0000269|PubMed:14766016, ECO:0000269|PubMed:7763314, ECO:0000269|PubMed:7903306}. |
| P12757 | SKIL | S26 | ochoa | Ski-like protein (Ski-related oncogene) (Ski-related protein) | May have regulatory role in cell division or differentiation in response to extracellular signals. |
| P12814 | ACTN1 | S172 | ochoa | Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000269|PubMed:22689882}. |
| P13861 | PRKAR2A | S58 | ochoa | cAMP-dependent protein kinase type II-alpha regulatory subunit | Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase. |
| P14635 | CCNB1 | S35 | ochoa | G2/mitotic-specific cyclin-B1 | Essential for the control of the cell cycle at the G2/M (mitosis) transition. {ECO:0000269|PubMed:17495531, ECO:0000269|PubMed:17495533, ECO:0000269|PubMed:27030811}. |
| P16070 | CD44 | S672 | psp | CD44 antigen (CDw44) (Epican) (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Heparan sulfate proteoglycan) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44) | Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment (PubMed:16541107, PubMed:19703720, PubMed:22726066). Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection (PubMed:7528188). Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases (PubMed:18757307, PubMed:23589287). Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion (PubMed:15123640). {ECO:0000269|PubMed:15123640, ECO:0000269|PubMed:16541107, ECO:0000269|PubMed:18757307, ECO:0000269|PubMed:19703720, ECO:0000269|PubMed:22726066, ECO:0000269|PubMed:23589287, ECO:0000269|PubMed:7528188}. |
| P18206 | VCL | S97 | ochoa | Vinculin (Metavinculin) (MV) | Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. {ECO:0000269|PubMed:20484056}. |
| P20839 | IMPDH1 | S416 | ochoa | Inosine-5'-monophosphate dehydrogenase 1 (IMP dehydrogenase 1) (IMPD 1) (IMPDH 1) (EC 1.1.1.205) (IMPDH-I) | Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. |
| P25098 | GRK2 | S29 | psp | Beta-adrenergic receptor kinase 1 (Beta-ARK-1) (EC 2.7.11.15) (G-protein coupled receptor kinase 2) | Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them (PubMed:19715378). Key regulator of LPAR1 signaling (PubMed:19306925). Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor (PubMed:19306925). Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (PubMed:19306925). Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity (By similarity). Inhibits relaxation of airway smooth muscle in response to blue light (PubMed:30284927). {ECO:0000250|UniProtKB:P21146, ECO:0000269|PubMed:19306925, ECO:0000269|PubMed:19715378, ECO:0000269|PubMed:30284927}. |
| P25705 | ATP5F1A | S451 | ochoa | ATP synthase F(1) complex subunit alpha, mitochondrial (ATP synthase F1 subunit alpha) | Subunit alpha, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (Probable). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). With the catalytic subunit beta (ATP5F1B), forms the catalytic core in the F(1) domain (PubMed:37244256). Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (Probable). Binds the bacterial siderophore enterobactin and can promote mitochondrial accumulation of enterobactin-derived iron ions (PubMed:30146159). {ECO:0000250|UniProtKB:P19483, ECO:0000269|PubMed:30146159, ECO:0000269|PubMed:37244256, ECO:0000305|PubMed:37244256}. |
| P29536 | LMOD1 | S44 | ochoa | Leiomodin-1 (64 kDa autoantigen 1D) (64 kDa autoantigen 1D3) (64 kDa autoantigen D1) (Leiomodin, muscle form) (Smooth muscle leiomodin) (SM-Lmod) (Thyroid-associated ophthalmopathy autoantigen) | Required for proper contractility of visceral smooth muscle cells (PubMed:28292896). Mediates nucleation of actin filaments. {ECO:0000269|PubMed:26370058, ECO:0000269|PubMed:28292896}. |
| P31327 | CPS1 | S1193 | ochoa | Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I) | Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. |
| P34896 | SHMT1 | Y77 | ochoa | Serine hydroxymethyltransferase, cytosolic (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase) | Interconversion of serine and glycine (PubMed:24698160, PubMed:8505317). {ECO:0000269|PubMed:24698160, ECO:0000269|PubMed:8505317}. |
| P34897 | SHMT2 | S266 | ochoa | Serine hydroxymethyltransferase, mitochondrial (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase) | Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis (PubMed:24075985, PubMed:25619277, PubMed:29364879, PubMed:33015733). Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate (PubMed:25619277). Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA (PubMed:21876188). Also required for mitochondrial translation by producing 5,10-methylenetetrahydrofolate; 5,10-methylenetetrahydrofolate providing methyl donors to produce the taurinomethyluridine base at the wobble position of some mitochondrial tRNAs (PubMed:29364879, PubMed:29452640). Associates with mitochondrial DNA (PubMed:18063578). In addition to its role in mitochondria, also plays a role in the deubiquitination of target proteins as component of the BRISC complex: required for IFNAR1 deubiquitination by the BRISC complex (PubMed:24075985). {ECO:0000269|PubMed:18063578, ECO:0000269|PubMed:21876188, ECO:0000269|PubMed:24075985, ECO:0000269|PubMed:25619277, ECO:0000269|PubMed:29364879, ECO:0000269|PubMed:29452640, ECO:0000269|PubMed:33015733}. |
| P35573 | AGL | S1027 | ochoa | Glycogen debranching enzyme (Glycogen debrancher) [Includes: 4-alpha-glucanotransferase (EC 2.4.1.25) (Oligo-1,4-1,4-glucantransferase); Amylo-alpha-1,6-glucosidase (Amylo-1,6-glucosidase) (EC 3.2.1.33) (Dextrin 6-alpha-D-glucosidase)] | Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. |
| P38935 | IGHMBP2 | S160 | ochoa | DNA-binding protein SMUBP-2 (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent helicase IGHMBP2) (Glial factor 1) (GF-1) (Immunoglobulin mu-binding protein 2) | 5' to 3' helicase that unwinds RNA and DNA duplexes in an ATP-dependent reaction (PubMed:19158098, PubMed:22999958, PubMed:30218034). Specific to 5'-phosphorylated single-stranded guanine-rich sequences (PubMed:22999958, PubMed:8349627). May play a role in RNA metabolism, ribosome biogenesis or initiation of translation (PubMed:19158098, PubMed:19299493). May play a role in regulation of transcription (By similarity). Interacts with tRNA-Tyr (PubMed:19299493). {ECO:0000250|UniProtKB:Q9EQN5, ECO:0000269|PubMed:19158098, ECO:0000269|PubMed:19299493, ECO:0000269|PubMed:22999958, ECO:0000269|PubMed:30218034, ECO:0000269|PubMed:8349627}. |
| P39019 | RPS19 | S74 | ochoa | Small ribosomal subunit protein eS19 (40S ribosomal protein S19) | Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Required for pre-rRNA processing and maturation of 40S ribosomal subunits (PubMed:16990592). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:16990592, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| P40926 | MDH2 | S246 | ochoa | Malate dehydrogenase, mitochondrial (EC 1.1.1.37) | None |
| P43243 | MATR3 | S37 | ochoa | Matrin-3 | May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32245947}. |
| P48681 | NES | S51 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P48736 | PIK3CG | S582 | psp | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PI3-kinase subunit gamma) (PI3K-gamma) (PI3Kgamma) (PtdIns-3-kinase subunit gamma) (EC 2.7.1.137) (EC 2.7.1.153) (EC 2.7.1.154) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma) (PtdIns-3-kinase subunit p110-gamma) (p110gamma) (Phosphoinositide-3-kinase catalytic gamma polypeptide) (Serine/threonine protein kinase PIK3CG) (EC 2.7.11.1) (p120-PI3K) | Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Links G-protein coupled receptor activation to PIP3 production. Involved in immune, inflammatory and allergic responses. Modulates leukocyte chemotaxis to inflammatory sites and in response to chemoattractant agents. May control leukocyte polarization and migration by regulating the spatial accumulation of PIP3 and by regulating the organization of F-actin formation and integrin-based adhesion at the leading edge. Controls motility of dendritic cells. Together with PIK3CD is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in T-lymphocyte migration. Regulates T-lymphocyte proliferation, activation, and cytokine production. Together with PIK3CD participates in T-lymphocyte development. Required for B-lymphocyte development and signaling. Together with PIK3CD participates in neutrophil respiratory burst. Together with PIK3CD is involved in neutrophil chemotaxis and extravasation. Together with PIK3CB promotes platelet aggregation and thrombosis. Regulates alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) adhesive function in platelets downstream of P2Y12 through a lipid kinase activity-independent mechanism. May have also a lipid kinase activity-dependent function in platelet aggregation. Involved in endothelial progenitor cell migration. Negative regulator of cardiac contractility. Modulates cardiac contractility by anchoring protein kinase A (PKA) and PDE3B activation, reducing cAMP levels. Regulates cardiac contractility also by promoting beta-adrenergic receptor internalization by binding to GRK2 and by non-muscle tropomyosin phosphorylation. Also has serine/threonine protein kinase activity: both lipid and protein kinase activities are required for beta-adrenergic receptor endocytosis. May also have a scaffolding role in modulating cardiac contractility. Contributes to cardiac hypertrophy under pathological stress. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis. In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway downstream of RASGRP4-mediated Ras-activation, to promote neutrophil functional responses (By similarity). {ECO:0000250|UniProtKB:Q9JHG7, ECO:0000269|PubMed:11277933, ECO:0000269|PubMed:12163475, ECO:0000269|PubMed:15135396, ECO:0000269|PubMed:15294162, ECO:0000269|PubMed:16094730, ECO:0000269|PubMed:16123124, ECO:0000269|PubMed:21393242, ECO:0000269|PubMed:31554793, ECO:0000269|PubMed:33054089, ECO:0000269|PubMed:7624799}. |
| P54760 | EPHB4 | S907 | ochoa | Ephrin type-B receptor 4 (EC 2.7.10.1) (Hepatoma transmembrane kinase) (Tyrosine-protein kinase TYRO11) | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. {ECO:0000269|PubMed:12734395, ECO:0000269|PubMed:16424904, ECO:0000269|PubMed:27400125, ECO:0000269|PubMed:30578106}. |
| P54762 | EPHB1 | S899 | ochoa | Ephrin type-B receptor 1 (EC 2.7.10.1) (ELK) (EPH tyrosine kinase 2) (EPH-like kinase 6) (EK6) (hEK6) (Neuronally-expressed EPH-related tyrosine kinase) (NET) (Tyrosine-protein kinase receptor EPH-2) | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance also plays an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively. Involved in the maintenance of the pool of satellite cells (muscle stem cells) by promoting their self-renewal and reducing their activation and differentiation (By similarity). {ECO:0000250|UniProtKB:Q8CBF3, ECO:0000269|PubMed:12223469, ECO:0000269|PubMed:12925710, ECO:0000269|PubMed:18034775, ECO:0000269|PubMed:9430661, ECO:0000269|PubMed:9499402}. |
| P68431 | H3C1 | S29 | ochoa | Histone H3.1 (Histone H3/a) (Histone H3/b) (Histone H3/c) (Histone H3/d) (Histone H3/f) (Histone H3/h) (Histone H3/i) (Histone H3/j) (Histone H3/k) (Histone H3/l) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| P78352 | DLG4 | S415 | ochoa | Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90) | Postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for the postsynaptic clustering of crucial synaptic proteins. Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression (By similarity). Under basal conditions, cooperates with FYN to stabilize palmitoyltransferase ZDHHC5 at the synaptic membrane through FYN-mediated phosphorylation of ZDHHC5 and its subsequent inhibition of association with endocytic proteins (PubMed:26334723). {ECO:0000250|UniProtKB:Q62108, ECO:0000269|PubMed:26334723}. |
| P78504 | JAG1 | S1101 | ochoa | Protein jagged-1 (Jagged1) (hJ1) (CD antigen CD339) | Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (PubMed:18660822, PubMed:20437614). May be involved in cell-fate decisions during hematopoiesis (PubMed:9462510). Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro). {ECO:0000250, ECO:0000269|PubMed:18660822, ECO:0000269|PubMed:20437614, ECO:0000269|PubMed:9462510}. |
| P78527 | PRKDC | S2624 | ochoa|psp | DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) | Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250|UniProtKB:P97313, ECO:0000269|PubMed:10026262, ECO:0000269|PubMed:10467406, ECO:0000269|PubMed:11889123, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12509254, ECO:0000269|PubMed:12649176, ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:14612514, ECO:0000269|PubMed:14627815, ECO:0000269|PubMed:14704337, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:15262962, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:1597196, ECO:0000269|PubMed:16046194, ECO:0000269|PubMed:16397295, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:2247066, ECO:0000269|PubMed:2507541, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30247612, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33854234, ECO:0000269|PubMed:34352203, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:8407951, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9362500, ECO:0000269|PubMed:9363941, ECO:0000269|PubMed:9679063}. |
| P84243 | H3-3A | S29 | ochoa | Histone H3.3 | Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15776021, ECO:0000269|PubMed:16258499}. |
| P98174 | FGD1 | S50 | ochoa | FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF) (Zinc finger FYVE domain-containing protein 3) | Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. {ECO:0000269|PubMed:8969170}. |
| Q01650 | SLC7A5 | S35 | ochoa | Large neutral amino acids transporter small subunit 1 (4F2 light chain) (4F2 LC) (4F2LC) (CD98 light chain) (Integral membrane protein E16) (E16) (L-type amino acid transporter 1) (hLAT1) (Solute carrier family 7 member 5) (y+ system cationic amino acid transporter) | The heterodimer with SLC3A2 functions as a sodium-independent, high-affinity transporter that mediates uptake of large neutral amino acids such as phenylalanine, tyrosine, leucine, histidine, methionine, tryptophan, valine, isoleucine and alanine (PubMed:10049700, PubMed:10574970, PubMed:11557028, PubMed:11564694, PubMed:12117417, PubMed:12225859, PubMed:15769744, PubMed:18262359, PubMed:25998567, PubMed:30867591, PubMed:9751058). The heterodimer with SLC3A2 mediates the uptake of L-DOPA (By similarity). Functions as an amino acid exchanger (PubMed:11557028, PubMed:12117417, PubMed:12225859, PubMed:30867591). May play a role in the transport of L-DOPA across the blood-brain barrier (By similarity). May act as the major transporter of tyrosine in fibroblasts (Probable). May mediate blood-to-retina L-leucine transport across the inner blood-retinal barrier (By similarity). Can mediate the transport of thyroid hormones diiodothyronine (T2), triiodothyronine (T3) and thyroxine (T4) across the cell membrane (PubMed:11564694). When associated with LAPTM4B, the heterodimer formed by SLC3A2 and SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation (PubMed:25998567). Involved in the uptake of toxic methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes (PubMed:12117417). Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the membrane (PubMed:15769744). {ECO:0000250|UniProtKB:Q63016, ECO:0000250|UniProtKB:Q9Z127, ECO:0000269|PubMed:10049700, ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:11557028, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:15769744, ECO:0000269|PubMed:18262359, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:9751058, ECO:0000305|PubMed:18262359}.; FUNCTION: (Microbial infection) In case of hepatitis C virus/HCV infection, the complex formed by SLC3A2 and SLC7A5/LAT1 plays a role in HCV propagation by facilitating viral entry into host cell and increasing L-leucine uptake-mediated mTORC1 signaling activation, thereby contributing to HCV-mediated pathogenesis. {ECO:0000269|PubMed:30341327}. |
| Q02790 | FKBP4 | S26 | ochoa | Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (51 kDa FK506-binding protein) (FKBP51) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed] | Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Also acts as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria. {ECO:0000269|PubMed:1279700, ECO:0000269|PubMed:1376003, ECO:0000269|PubMed:19945390, ECO:0000269|PubMed:21730050, ECO:0000269|PubMed:2378870}. |
| Q04206 | RELA | S205 | psp | Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3) | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric RELA-NFKB1 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. The NF-kappa-B heterodimeric RELA-NFKB1 and RELA-REL complexes, for instance, function as transcriptional activators. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The inhibitory effect of I-kappa-B on NF-kappa-B through retention in the cytoplasm is exerted primarily through the interaction with RELA. RELA shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Besides its activity as a direct transcriptional activator, it is also able to modulate promoters accessibility to transcription factors and thereby indirectly regulate gene expression. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells (PubMed:15790681). The NF-kappa-B homodimeric RELA-RELA complex appears to be involved in invasin-mediated activation of IL-8 expression. Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000269|PubMed:10928981, ECO:0000269|PubMed:12748188, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:17000776, ECO:0000269|PubMed:17620405, ECO:0000269|PubMed:19058135, ECO:0000269|PubMed:19103749, ECO:0000269|PubMed:20547752, ECO:0000269|PubMed:33440148}. |
| Q05682 | CALD1 | S58 | ochoa | Caldesmon (CDM) | Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity). {ECO:0000250, ECO:0000269|PubMed:8227296}. |
| Q09666 | AHNAK | S20 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q0P6D2 | DIPK1C | S51 | psp | Divergent protein kinase domain 1C (Protein FAM69C) | None |
| Q13009 | TIAM1 | S231 | ochoa|psp | Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1) | Guanyl-nucleotide exchange factor that activates RHO-like proteins and connects extracellular signals to cytoskeletal activities. Activates RAC1, CDC42, and to a lesser extent RHOA and their downstream signaling to regulate processes like cell adhesion and cell migration. {ECO:0000269|PubMed:20361982, ECO:0000269|PubMed:25684205}. |
| Q13428 | TCOF1 | S678 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q13523 | PRP4K | S636 | ochoa | Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog) | Serine/threonine kinase involved in spliceosomal assembly as well as mitosis and signaling regulation (PubMed:10799319, PubMed:12077342, PubMed:17513757, PubMed:17998396). Connects chromatin mediated regulation of transcription and pre-mRNA splicing (PubMed:12077342). During spliceosomal assembly, interacts with and phosphorylates PRPF6 and PRPF31, components of the U4/U6-U5 tri-small nuclear ribonucleoprotein (snRNP), to facilitate the formation of the spliceosome B complex. Plays a role in regulating transcription and the spindle assembly checkpoint (SAC) (PubMed:20118938). Associates with U5 snRNP and NCOR1 deacetylase complexes which may allow a coordination of pre-mRNA splicing with chromatin remodeling events involved in transcriptional regulation (PubMed:12077342). Associates and probably phosphorylates SMARCA4 and NCOR1 (PubMed:12077342). Phosphorylates SRSF1 (PubMed:11418604). Associates with kinetochores during mitosis and is necessary for recruitment and maintenance of the checkpoint proteins such as MAD1L1 and MAD12L1 at the kinetochores (PubMed:17998396). Phosphorylates and regulates the activity of the transcription factors such as ELK1 and KLF13 (PubMed:10799319, PubMed:17513757). Phosphorylates nuclear YAP1 and WWTR1/TAZ which induces nuclear exclusion and regulates Hippo signaling pathway, involved in tissue growth control (PubMed:29695716). {ECO:0000269|PubMed:10799319, ECO:0000269|PubMed:11418604, ECO:0000269|PubMed:12077342, ECO:0000269|PubMed:17513757, ECO:0000269|PubMed:17998396, ECO:0000269|PubMed:20118938, ECO:0000269|PubMed:29695716}. |
| Q14126 | DSG2 | S1059 | ochoa | Desmoglein-2 (Cadherin family member 5) (HDGC) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:38395410). Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Required for proliferation and viability of embryonic stem cells in the blastocyst, thereby crucial for progression of post-implantation embryonic development (By similarity). Maintains pluripotency by regulating epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via interacting with and sequestering CTNNB1 to sites of cell-cell contact, thereby reducing translocation of CTNNB1 to the nucleus and subsequent transcription of CTNNB1/TCF-target genes (PubMed:29910125). Promotes pluripotency and the multi-lineage differentiation potential of hematopoietic stem cells (PubMed:27338829). Plays a role in endothelial cell sprouting and elongation via mediating the junctional-association of cortical actin fibers and CDH5 (PubMed:27338829). Plays a role in limiting inflammatory infiltration and the apoptotic response to injury in kidney tubular epithelial cells, potentially via its role in maintaining cell-cell adhesion and the epithelial barrier (PubMed:38395410). {ECO:0000250|UniProtKB:O55111, ECO:0000269|PubMed:27338829, ECO:0000269|PubMed:29910125, ECO:0000269|PubMed:38395410}. |
| Q14141 | SEPTIN6 | S27 | ochoa | Septin-6 | Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). {ECO:0000269|PubMed:17229681, ECO:0000269|PubMed:17803907, ECO:0000305|PubMed:25588830}. |
| Q14157 | UBAP2L | S95 | ochoa | Ubiquitin-associated protein 2-like (Protein NICE-4) (RNA polymerase II degradation factor UBAP2L) | Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs) (By similarity). Is a regulator of stress granule assembly, required for their efficient formation (PubMed:29395067, PubMed:35977029). Required for proper brain development and neocortex lamination (By similarity). {ECO:0000250|UniProtKB:Q80X50, ECO:0000269|PubMed:29395067, ECO:0000269|PubMed:35633597}. |
| Q14185 | DOCK1 | S1250 | psp | Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180) | Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829). Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1 (PubMed:8657152). {ECO:0000269|PubMed:19004829, ECO:0000269|PubMed:8657152}. |
| Q14244 | MAP7 | S282 | ochoa | Ensconsin (Epithelial microtubule-associated protein of 115 kDa) (E-MAP-115) (Microtubule-associated protein 7) (MAP-7) | Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments. {ECO:0000269|PubMed:11719555, ECO:0000269|PubMed:8408219, ECO:0000269|PubMed:9989799}. |
| Q14692 | BMS1 | S625 | ochoa | Ribosome biogenesis protein BMS1 homolog (EC 3.6.5.-) (Ribosome assembly protein BMS1 homolog) | GTPase required for the synthesis of 40S ribosomal subunits and for processing of pre-ribosomal RNA (pre-rRNA) at sites A0, A1, and A2. Controls access of pre-rRNA intermediates to RCL1 during ribosome biogenesis by binding RCL1 in a GTP-dependent manner, and delivering it to pre-ribosomes. GTP-binding and/or GTP hydrolysis may induce conformational rearrangements within the BMS1-RCL1 complex allowing the interaction of RCL1 with its RNA substrate. Required for RCL1 import into the nucleus. {ECO:0000250|UniProtKB:Q08965}. |
| Q14980 | NUMA1 | S1280 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q15139 | PRKD1 | S548 | ochoa | Serine/threonine-protein kinase D1 (EC 2.7.11.13) (Protein kinase C mu type) (Protein kinase D) (nPKC-D1) (nPKC-mu) | Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response (PubMed:10764790, PubMed:12505989, PubMed:12637538, PubMed:17442957, PubMed:18509061, PubMed:19135240, PubMed:19211839). Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation (PubMed:10523301). Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the heterotrimeric G-protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane. May act by activating the lipid kinase phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the local synthesis of phosphorylated inositol lipids, which induces a sequential production of DAG, phosphatidic acid (PA) and lyso-PA (LPA) that are necessary for membrane fission and generation of specific transport carriers to the cell surface. Under oxidative stress, is phosphorylated at Tyr-463 via SRC-ABL1 and contributes to cell survival by activating IKK complex and subsequent nuclear translocation and activation of NFKB1 (PubMed:12505989). Involved in cell migration by regulating integrin alpha-5/beta-3 recycling and promoting its recruitment in newly forming focal adhesion. In osteoblast differentiation, mediates the bone morphogenetic protein 2 (BMP2)-induced nuclear export of HDAC7, which results in the inhibition of HDAC7 transcriptional repression of RUNX2 (PubMed:18509061). In neurons, plays an important role in neuronal polarity by regulating the biogenesis of TGN-derived dendritic vesicles, and is involved in the maintenance of dendritic arborization and Golgi structure in hippocampal cells. May potentiate mitogenesis induced by the neuropeptide bombesin or vasopressin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. Plays an important role in the proliferative response induced by low calcium in keratinocytes, through sustained activation of MAPK1/3 (ERK1/2) pathway. Downstream of novel PKC signaling, plays a role in cardiac hypertrophy by phosphorylating HDAC5, which in turn triggers XPO1/CRM1-dependent nuclear export of HDAC5, MEF2A transcriptional activation and induction of downstream target genes that promote myocyte hypertrophy and pathological cardiac remodeling (PubMed:18332134). Mediates cardiac troponin I (TNNI3) phosphorylation at the PKA sites, which results in reduced myofilament calcium sensitivity, and accelerated crossbridge cycling kinetics. The PRKD1-HDAC5 pathway is also involved in angiogenesis by mediating VEGFA-induced specific subset of gene expression, cell migration, and tube formation (PubMed:19211839). In response to VEGFA, is necessary and required for HDAC7 phosphorylation which induces HDAC7 nuclear export and endothelial cell proliferation and migration. During apoptosis induced by cytarabine and other genotoxic agents, PRKD1 is cleaved by caspase-3 at Asp-378, resulting in activation of its kinase function and increased sensitivity of cells to the cytotoxic effects of genotoxic agents (PubMed:10764790). In epithelial cells, is required for transducing flagellin-stimulated inflammatory responses by binding and phosphorylating TLR5, which contributes to MAPK14/p38 activation and production of inflammatory cytokines (PubMed:17442957). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity). May play a role in inflammatory response by mediating activation of NF-kappa-B. May be involved in pain transmission by directly modulating TRPV1 receptor (PubMed:15471852). Plays a role in activated KRAS-mediated stabilization of ZNF304 in colorectal cancer (CRC) cells (PubMed:24623306). Regulates nuclear translocation of transcription factor TFEB in macrophages upon live S.enterica infection (By similarity). {ECO:0000250|UniProtKB:Q62101, ECO:0000269|PubMed:10523301, ECO:0000269|PubMed:10764790, ECO:0000269|PubMed:12505989, ECO:0000269|PubMed:12637538, ECO:0000269|PubMed:15471852, ECO:0000269|PubMed:17442957, ECO:0000269|PubMed:18332134, ECO:0000269|PubMed:18509061, ECO:0000269|PubMed:19135240, ECO:0000269|PubMed:19211839, ECO:0000269|PubMed:24623306}. |
| Q15327 | ANKRD1 | S213 | ochoa | Ankyrin repeat domain-containing protein 1 (Cardiac ankyrin repeat protein) (Cytokine-inducible gene C-193 protein) (Cytokine-inducible nuclear protein) | May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes. Induction seems to be correlated with apoptotic cell death in hepatoma cells. {ECO:0000269|PubMed:15805281, ECO:0000269|PubMed:7730328}. |
| Q15418 | RPS6KA1 | S72 | ochoa | Ribosomal protein S6 kinase alpha-1 (S6K-alpha-1) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (p90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPK-activated protein kinase 1a) (MAPKAP kinase 1a) (MAPKAPK-1a) (Ribosomal S6 kinase 1) (RSK-1) | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1 (PubMed:10679322, PubMed:12213813, PubMed:15117958, PubMed:16223362, PubMed:17360704, PubMed:18722121, PubMed:26158630, PubMed:35772404, PubMed:9430688). In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes (PubMed:18508509, PubMed:18813292). In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP (PubMed:12213813, PubMed:16223362). Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity (PubMed:18508509, PubMed:18813292). Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the pre-initiation complex (PubMed:17360704). In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation (PubMed:16763566). Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway (PubMed:15342917). Also involved in feedback regulation of mTORC1 and mTORC2 by phosphorylating DEPTOR (PubMed:22017876). Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function (PubMed:10679322, PubMed:16213824). Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4) (PubMed:11684016). Mediates induction of hepatocyte prolifration by TGFA through phosphorylation of CEBPB (PubMed:18508509, PubMed:18813292). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression (PubMed:18508509, PubMed:18813292). Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630). In response to mTORC1 activation, phosphorylates EIF4B at 'Ser-406' and 'Ser-422' which stimulates bicarbonate cotransporter SLC4A7 mRNA translation, increasing SLC4A7 protein abundance and function (PubMed:35772404). {ECO:0000269|PubMed:10679322, ECO:0000269|PubMed:11684016, ECO:0000269|PubMed:12213813, ECO:0000269|PubMed:15117958, ECO:0000269|PubMed:15342917, ECO:0000269|PubMed:16213824, ECO:0000269|PubMed:16223362, ECO:0000269|PubMed:16763566, ECO:0000269|PubMed:17360704, ECO:0000269|PubMed:18722121, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:35772404, ECO:0000269|PubMed:9430688, ECO:0000303|PubMed:18508509, ECO:0000303|PubMed:18813292}.; FUNCTION: (Microbial infection) Promotes the late transcription and translation of viral lytic genes during Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, when constitutively activated. {ECO:0000269|PubMed:30842327}. |
| Q15596 | NCOA2 | S851 | ochoa | Nuclear receptor coactivator 2 (NCoA-2) (Class E basic helix-loop-helix protein 75) (bHLHe75) (Transcriptional intermediary factor 2) (hTIF2) | Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:23508108, PubMed:8670870, PubMed:9430642, PubMed:22504882, PubMed:26553876). Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) (PubMed:23508108, PubMed:8670870, PubMed:9430642). Required with NCOA1 to control energy balance between white and brown adipose tissues (PubMed:23508108, PubMed:8670870, PubMed:9430642). Critical regulator of glucose metabolism regulation, acts as a RORA coactivator to specifically modulate G6PC1 expression (PubMed:23508108, PubMed:8670870, PubMed:9430642). Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3 (PubMed:23508108). Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-BMAL1 heterodimer (By similarity). {ECO:0000250|UniProtKB:Q61026, ECO:0000269|PubMed:22504882, ECO:0000269|PubMed:23508108, ECO:0000269|PubMed:26553876, ECO:0000269|PubMed:8670870, ECO:0000269|PubMed:9430642}. |
| Q15746 | MYLK | S1123 | ochoa | Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Kinase-related protein) (KRP) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form] | Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessary for physiological and asthmatic airway resistance. Necessary for gastrointestinal motility. Implicated in the regulation of endothelial as well as vascular permeability, probably via the regulation of cytoskeletal rearrangements. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. Critical participant in signaling sequences that result in fibroblast apoptosis. Plays a role in the regulation of epithelial cell survival. Required for epithelial wound healing, especially during actomyosin ring contraction during purse-string wound closure. Mediates RhoA-dependent membrane blebbing. Triggers TRPC5 channel activity in a calcium-dependent signaling, by inducing its subcellular localization at the plasma membrane. Promotes cell migration (including tumor cells) and tumor metastasis. PTK2B/PYK2 activation by phosphorylation mediates ITGB2 activation and is thus essential to trigger neutrophil transmigration during acute lung injury (ALI). May regulate optic nerve head astrocyte migration. Probably involved in mitotic cytoskeletal regulation. Regulates tight junction probably by modulating ZO-1 exchange in the perijunctional actomyosin ring. Mediates burn-induced microvascular barrier injury; triggers endothelial contraction in the development of microvascular hyperpermeability by phosphorylating MLC. Essential for intestinal barrier dysfunction. Mediates Giardia spp.-mediated reduced epithelial barrier function during giardiasis intestinal infection via reorganization of cytoskeletal F-actin and tight junctional ZO-1. Necessary for hypotonicity-induced Ca(2+) entry and subsequent activation of volume-sensitive organic osmolyte/anion channels (VSOAC) in cervical cancer cells. Responsible for high proliferative ability of breast cancer cells through anti-apoptosis. {ECO:0000269|PubMed:11113114, ECO:0000269|PubMed:11976941, ECO:0000269|PubMed:15020676, ECO:0000269|PubMed:15825080, ECO:0000269|PubMed:16284075, ECO:0000269|PubMed:16723733, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:18710790, ECO:0000269|PubMed:19826488, ECO:0000269|PubMed:20139351, ECO:0000269|PubMed:20181817, ECO:0000269|PubMed:20375339, ECO:0000269|PubMed:20453870}. |
| Q16695 | H3-4 | S29 | ochoa | Histone H3.1t (H3/t) (H3t) (H3/g) (Histone H3.4) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q16706 | MAN2A1 | S943 | ochoa | Alpha-mannosidase 2 (EC 3.2.1.114) (Golgi alpha-mannosidase II) (AMan II) (Man II) (Mannosidase alpha class 2A member 1) (Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase) | Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway. {ECO:0000250|UniProtKB:P28494}. |
| Q4V9L6 | TMEM119 | S185 | ochoa | Transmembrane protein 119 (Osteoblast induction factor) (OBIF) | Plays an important role in bone formation and normal bone mineralization. Promotes the differentiation of myoblasts into osteoblasts (PubMed:20025746). May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway. Up-regulates the expression of ATF4, a transcription factor which plays a central role in osteoblast differentiation. Essential for normal spermatogenesis and late testicular differentiation (By similarity). {ECO:0000250|UniProtKB:Q8R138, ECO:0000269|PubMed:20025746}. |
| Q5BKX6 | SLC45A4 | S456 | ochoa | Solute carrier family 45 member 4 | Proton-associated sucrose transporter. May be able to transport also glucose and fructose. {ECO:0000250|UniProtKB:Q0P5V9}. |
| Q5M7Z0 | RNFT1 | S53 | ochoa | E3 ubiquitin-protein ligase RNFT1 (EC 2.3.2.27) (Protein PTD016) (RING finger and transmembrane domain-containing protein 1) | E3 ubiquitin-protein ligase that acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis. {ECO:0000269|PubMed:27485036}. |
| Q5SXM8 | DNLZ | S157 | ochoa | DNL-type zinc finger protein (Hsp70-escort protein 1) (HEP1) (mtHsp70-escort protein) | May function as a co-chaperone towards HSPA9/mortalin which, by itself, is prone to self-aggregation. {ECO:0000269|PubMed:23462535}. |
| Q5TEC6 | H3-7 | S29 | ochoa | Histone H3-7 | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. {ECO:0000250|UniProtKB:P68431}. |
| Q5THJ4 | VPS13D | S1027 | ochoa | Intermembrane lipid transfer protein VPS13D (Vacuolar protein sorting-associated protein 13D) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:29307555, ECO:0000269|PubMed:29604224}. |
| Q5THJ4 | VPS13D | S1034 | ochoa | Intermembrane lipid transfer protein VPS13D (Vacuolar protein sorting-associated protein 13D) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:29307555, ECO:0000269|PubMed:29604224}. |
| Q6DN90 | IQSEC1 | S925 | ochoa | IQ motif and SEC7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein) (BRAG2) | Guanine nucleotide exchange factor for ARF1 and ARF6 (PubMed:11226253, PubMed:24058294). Guanine nucleotide exchange factor activity is enhanced by lipid binding (PubMed:24058294). Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalization of beta-1 integrin (PubMed:16461286). Involved in neuronal development (Probable). In neurons, plays a role in the control of vesicle formation by endocytoc cargo. Upon long term depression, interacts with GRIA2 and mediates the activation of ARF6 to internalize synaptic AMPAR receptors (By similarity). {ECO:0000250|UniProtKB:A0A0G2JUG7, ECO:0000269|PubMed:11226253, ECO:0000269|PubMed:16461286, ECO:0000269|PubMed:24058294, ECO:0000305|PubMed:31607425}. |
| Q6NYC8 | PPP1R18 | S398 | ochoa | Phostensin (Protein phosphatase 1 F-actin cytoskeleton-targeting subunit) (Protein phosphatase 1 regulatory subunit 18) | [Isoform 1]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:24434620}.; FUNCTION: [Isoform 4]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:17374523}. |
| Q6PH81 | C16orf87 | S50 | ochoa | UPF0547 protein C16orf87 | None |
| Q6R327 | RICTOR | S1344 | ochoa | Rapamycin-insensitive companion of mTOR (AVO3 homolog) (hAVO3) | Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15268862, PubMed:15718470, PubMed:19720745, PubMed:19995915, PubMed:21343617, PubMed:33158864, PubMed:35904232, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:19720745, PubMed:19935711, PubMed:19995915). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:15467718, PubMed:21343617). Within the mTORC2 complex, RICTOR probably acts as a molecular adapter (PubMed:21343617, PubMed:33158864, PubMed:35926713). RICTOR is responsible for the FKBP12-rapamycin-insensitivity of mTORC2 (PubMed:33158864). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:15718470, PubMed:19720745, PubMed:19935711, PubMed:35926713). mTORC2 catalyzes the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657' (By similarity). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:15467718). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (PubMed:15467718). {ECO:0000250|UniProtKB:Q6QI06, ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15718470, ECO:0000269|PubMed:19720745, ECO:0000269|PubMed:19935711, ECO:0000269|PubMed:19995915, ECO:0000269|PubMed:21343617, ECO:0000269|PubMed:33158864, ECO:0000269|PubMed:35904232, ECO:0000269|PubMed:35926713}. |
| Q71DI3 | H3C15 | S29 | ochoa | Histone H3.2 (H3-clustered histone 13) (H3-clustered histone 14) (H3-clustered histone 15) (Histone H3/m) (Histone H3/o) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q7Z5L9 | IRF2BP2 | S290 | ochoa | Interferon regulatory factor 2-binding protein 2 (IRF-2-binding protein 2) (IRF-2BP2) | Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities (PubMed:12799427). Represses the NFAT1-dependent transactivation of NFAT-responsive promoters (PubMed:21576369). Acts as a coactivator of VEGFA expression in cardiac and skeletal muscles (PubMed:20702774). Plays a role in immature B-cell differentiation (PubMed:27016798). {ECO:0000269|PubMed:12799427, ECO:0000269|PubMed:20702774, ECO:0000269|PubMed:21576369, ECO:0000269|PubMed:27016798}. |
| Q86SQ0 | PHLDB2 | S175 | ochoa | Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) | Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}. |
| Q86UU1 | PHLDB1 | S1017 | ochoa | Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha) | None |
| Q86VS8 | HOOK3 | S693 | ochoa | Protein Hook homolog 3 (h-hook3) (hHK3) | Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Predominantly recruits 2 dyneins, which increases both the force and speed of the microtubule motor (PubMed:25035494, PubMed:33734450). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). {ECO:0000250|UniProtKB:Q8BUK6, ECO:0000269|PubMed:11238449, ECO:0000269|PubMed:17237231, ECO:0000269|PubMed:18799622, ECO:0000269|PubMed:25035494, ECO:0000269|PubMed:32073997, ECO:0000269|PubMed:33734450}.; FUNCTION: (Microbial infection) May serve as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking. {ECO:0000305}. |
| Q86XR8 | CEP57 | S22 | ochoa | Centrosomal protein of 57 kDa (Cep57) (FGF2-interacting protein) (Testis-specific protein 57) (Translokin) | Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring-like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2, but that of FGF1. {ECO:0000269|PubMed:22321063}. |
| Q8IVL0 | NAV3 | S988 | ochoa | Neuron navigator 3 (Pore membrane and/or filament-interacting-like protein 1) (Steerin-3) (Unc-53 homolog 3) (unc53H3) | Plays a role in cell migration (PubMed:21471154). May be involved in neuron regeneration. May regulate IL2 production by T-cells. {ECO:0000269|PubMed:16166283, ECO:0000269|PubMed:21471154}. |
| Q8IWC1 | MAP7D3 | S169 | ochoa | MAP7 domain-containing protein 3 | Promotes the assembly and stability of microtubules. {ECO:0000269|PubMed:22142902, ECO:0000269|PubMed:24927501}. |
| Q8IX01 | SUGP2 | S224 | ochoa | SURP and G-patch domain-containing protein 2 (Arginine/serine-rich-splicing factor 14) (Splicing factor, arginine/serine-rich 14) | May play a role in mRNA splicing. {ECO:0000305}. |
| Q8IY67 | RAVER1 | S511 | ochoa | Ribonucleoprotein PTB-binding 1 (Protein raver-1) | Cooperates with PTBP1 to modulate regulated alternative splicing events. Promotes exon skipping. Cooperates with PTBP1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA (By similarity). {ECO:0000250}. |
| Q8IYW5 | RNF168 | S237 | ochoa | E3 ubiquitin-protein ligase RNF168 (hRNF168) (EC 2.3.2.27) (RING finger protein 168) (RING-type E3 ubiquitin transferase RNF168) | E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20/C1orf86 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. Following DNA damage, promotes the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF8, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Not able to initiate 'Lys-63'-linked ubiquitination in vitro; possibly due to partial occlusion of the UBE2N/UBC13-binding region. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively). {ECO:0000255|HAMAP-Rule:MF_03066, ECO:0000269|PubMed:19203578, ECO:0000269|PubMed:19203579, ECO:0000269|PubMed:20550933, ECO:0000269|PubMed:22373579, ECO:0000269|PubMed:22705371, ECO:0000269|PubMed:22713238, ECO:0000269|PubMed:22742833, ECO:0000269|PubMed:22980979, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538}. |
| Q8NEU8 | APPL2 | S329 | ochoa | DCC-interacting protein 13-beta (Dip13-beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2) | Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism (PubMed:15016378, PubMed:24879834, PubMed:26583432). Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex (PubMed:15016378). Plays a role in immune response by modulating phagocytosis, inflammatory and innate immune responses. In macrophages, enhances Fc-gamma receptor-mediated phagocytosis through interaction with RAB31 leading to activation of PI3K/Akt signaling. In response to LPS, modulates inflammatory responses by playing a key role on the regulation of TLR4 signaling and in the nuclear translocation of RELA/NF-kappa-B p65 and the secretion of pro- and anti-inflammatory cytokines. Also functions as a negative regulator of innate immune response via inhibition of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1 (By similarity). Plays a role in endosomal trafficking of TGFBR1 from the endosomes to the nucleus (PubMed:26583432). Plays a role in cell metabolism by regulating adiponecting ans insulin signaling pathways and adaptative thermogenesis (By similarity) (PubMed:24879834). In muscle, negatively regulates adiponectin-simulated glucose uptake and fatty acid oxidation by inhibiting adiponectin signaling pathway through APPL1 sequestration thereby antagonizing APPL1 action (By similarity). In muscles, negatively regulates insulin-induced plasma membrane recruitment of GLUT4 and glucose uptake through interaction with TBC1D1 (PubMed:24879834). Plays a role in cold and diet-induced adaptive thermogenesis by activating ventromedial hypothalamus (VMH) neurons throught AMPK inhibition which enhances sympathetic outflow to subcutaneous white adipose tissue (sWAT), sWAT beiging and cold tolerance (By similarity). Also plays a role in other signaling pathways namely Wnt/beta-catenin, HGF and glucocorticoid receptor signaling (By similarity) (PubMed:19433865). Positive regulator of beta-catenin/TCF-dependent transcription through direct interaction with RUVBL2/reptin resulting in the relief of RUVBL2-mediated repression of beta-catenin/TCF target genes by modulating the interactions within the beta-catenin-reptin-HDAC complex (PubMed:19433865). May affect adult neurogenesis in hippocampus and olfactory system via regulating the sensitivity of glucocorticoid receptor. Required for fibroblast migration through HGF cell signaling (By similarity). {ECO:0000250|UniProtKB:Q8K3G9, ECO:0000269|PubMed:15016378, ECO:0000269|PubMed:19433865, ECO:0000269|PubMed:24879834, ECO:0000269|PubMed:26583432}. |
| Q8NF99 | ZNF397 | S242 | ochoa | Zinc finger protein 397 (Zinc finger and SCAN domain-containing protein 15) (Zinc finger protein 47) | Isoform 3 acts as a DNA-dependent transcriptional repressor. {ECO:0000269|PubMed:12801647}. |
| Q8TDM6 | DLG5 | S900 | ochoa | Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG) | Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). {ECO:0000250|UniProtKB:E9Q9R9, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:28169360}. |
| Q8TF01 | PNISR | S381 | ochoa | Arginine/serine-rich protein PNISR (PNN-interacting serine/arginine-rich protein) (SR-related protein) (SR-rich protein) (Serine/arginine-rich-splicing regulatory protein 130) (SRrp130) (Splicing factor, arginine/serine-rich 130) (Splicing factor, arginine/serine-rich 18) | None |
| Q8TF05 | PPP4R1 | S538 | ochoa | Serine/threonine-protein phosphatase 4 regulatory subunit 1 | Regulatory subunit of serine/threonine-protein phosphatase 4. May play a role in regulation of cell division in renal glomeruli. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. Plays a role in the inhibition of TNF-induced NF-kappa-B activation by regulating the dephosphorylation of TRAF2. {ECO:0000269|PubMed:15805470}.; FUNCTION: (Microbial infection) Participates in merkel polyomavirus-mediated inhibition of NF-kappa-B by bridging viral small tumor antigen with NEMO. {ECO:0000269|PubMed:28445980}. |
| Q92833 | JARID2 | S278 | ochoa | Protein Jumonji (Jumonji/ARID domain-containing protein 2) | Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis (PubMed:20075857). Acts as an accessory subunit for the core PRC2 (Polycomb repressive complex 2) complex, which mediates histone H3K27 (H3K27me3) trimethylation on chromatin (PubMed:20075857, PubMed:29499137, PubMed:31959557). Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells, thereby playing a key role in stem cell differentiation and normal embryonic development (PubMed:20075857). In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases (By similarity). Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5 (By similarity). Participates in the negative regulation of cell proliferation signaling (By similarity). Does not have histone demethylase activity (By similarity). {ECO:0000250|UniProtKB:Q62315, ECO:0000269|PubMed:20075857, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}. |
| Q96PU5 | NEDD4L | S428 | psp | E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2) | E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins and is thereby implicated in the regulation of various signaling pathways including autophagy, innate immunity or DNA repair (PubMed:20064473, PubMed:31959741, PubMed:33608556). Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation (PubMed:15496141). Downregulates autophagy and cell growth by ubiquitinating and reducing cellular ULK1 or ASCT2 levels (PubMed:28820317, PubMed:31959741). Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5 (PubMed:26363003, PubMed:27445338). Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Involved in the regulation of TOR signaling (PubMed:27694961). Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF (PubMed:27445338). Plays a role in antiviral innate immunity by catalyzing 'Lys-29'-linked cysteine ubiquitination of TRAF3, resulting in enhanced 'Lys-48' and 'Lys-63'-linked ubiquitination of TRAF3 (PubMed:33608556). Ubiquitinates TTYH2 and TTYH3 and regulates protein levels of TTYH2 (PubMed:18577513). {ECO:0000250|UniProtKB:Q8CFI0, ECO:0000269|PubMed:12911626, ECO:0000269|PubMed:15040001, ECO:0000269|PubMed:15217910, ECO:0000269|PubMed:15489223, ECO:0000269|PubMed:15496141, ECO:0000269|PubMed:15576372, ECO:0000269|PubMed:18577513, ECO:0000269|PubMed:19144635, ECO:0000269|PubMed:23999003, ECO:0000269|PubMed:25631046, ECO:0000269|PubMed:26363003, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:27694961, ECO:0000269|PubMed:33608556}. |
| Q96RY5 | CRAMP1 | S1187 | ochoa | Protein cramped-like (Cramped chromatin regulator homolog 1) (Hematological and neurological expressed 1-like protein) | None |
| Q99569 | PKP4 | S1091 | ochoa | Plakophilin-4 (p0071) | Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269|PubMed:17115030}. |
| Q99698 | LYST | S2241 | ochoa | Lysosomal-trafficking regulator (Beige homolog) | Adapter protein that regulates and/or fission of intracellular vesicles such as lysosomes (PubMed:11984006, PubMed:25216107). Might regulate trafficking of effectors involved in exocytosis (PubMed:25425525). In cytotoxic T-cells and natural killer (NK) cells, has role in the regulation of size, number and exocytosis of lytic granules (PubMed:26478006). In macrophages and dendritic cells, regulates phagosome maturation by controlling the conversion of early phagosomal compartments into late phagosomes (By similarity). In macrophages and dendritic cells, specifically involved in TLR3- and TLR4-induced production of pro-inflammatory cytokines by regulating the endosomal TLR3- TICAM1/TRIF and TLR4- TICAM1/TRIF signaling pathways (PubMed:27881733). {ECO:0000250|UniProtKB:P97412, ECO:0000269|PubMed:11984006, ECO:0000269|PubMed:25216107, ECO:0000269|PubMed:25425525, ECO:0000269|PubMed:26478006, ECO:0000269|PubMed:27881733}. |
| Q9BQQ3 | GORASP1 | S189 | psp | Golgi reassembly-stacking protein 1 (Golgi peripheral membrane protein p65) (Golgi phosphoprotein 5) (GOLPH5) (Golgi reassembly-stacking protein of 65 kDa) (GRASP65) | Key structural protein of the Golgi apparatus (PubMed:33301566). The membrane cisternae of the Golgi apparatus adhere to each other to form stacks, which are aligned side by side to form the Golgi ribbon (PubMed:33301566). Acting in concert with GORASP2/GRASP55, is required for the formation and maintenance of the Golgi ribbon, and may be dispensable for the formation of stacks (PubMed:33301566). However, other studies suggest that GORASP1 plays an important role in assembly and membrane stacking of the cisternae, and in the reassembly of Golgi stacks after breakdown during mitosis (By similarity). Caspase-mediated cleavage of GORASP1 is required for fragmentation of the Golgi during apoptosis (By similarity). Also mediates, via its interaction with GOLGA2/GM130, the docking of transport vesicles with the Golgi membranes (PubMed:16489344). Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (PubMed:21884936). {ECO:0000250|UniProtKB:O35254, ECO:0000269|PubMed:16489344, ECO:0000269|PubMed:21884936, ECO:0000269|PubMed:33301566}. |
| Q9BRG2 | SH2D3A | S147 | ochoa | SH2 domain-containing protein 3A (Novel SH2-containing protein 1) | May play a role in JNK activation. |
| Q9BYB0 | SHANK3 | S555 | ochoa | SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) | Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. {ECO:0000269|PubMed:24132240}. |
| Q9BZ23 | PANK2 | S171 | ochoa | Pantothenate kinase 2, mitochondrial (hPanK2) (EC 2.7.1.33) (Pantothenic acid kinase 2) [Cleaved into: Pantothenate kinase 2, mitochondrial intermediate form (iPanK2); Pantothenate kinase 2, mitochondrial mature form (mPanK2)] | [Isoform 1]: Mitochondrial isoform that catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis (PubMed:15659606, PubMed:16272150, PubMed:17242360, PubMed:17825826). Required for angiogenic activity of umbilical vein of endothelial cells (HUVEC) (PubMed:30221726). {ECO:0000269|PubMed:15659606, ECO:0000269|PubMed:16272150, ECO:0000269|PubMed:17242360, ECO:0000269|PubMed:17825826, ECO:0000269|PubMed:30221726}.; FUNCTION: [Isoform 4]: Cytoplasmic isoform that catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis. {ECO:0000269|PubMed:16272150}. |
| Q9C0C2 | TNKS1BP1 | S1073 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9H1D0 | TRPV6 | S184 | psp | Transient receptor potential cation channel subfamily V member 6 (TrpV6) (CaT-like) (CaT-L) (Calcium transport protein 1) (CaT1) (Epithelial calcium channel 2) (ECaC2) | Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine (PubMed:11097838, PubMed:11248124, PubMed:11278579, PubMed:15184369, PubMed:23612980, PubMed:29258289). Important for normal Ca(2+) ion homeostasis in the body, including bone and skin (By similarity). The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification (PubMed:15184369). Inactivation includes both a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism; the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating. {ECO:0000250|UniProtKB:Q91WD2, ECO:0000269|PubMed:11097838, ECO:0000269|PubMed:11248124, ECO:0000269|PubMed:11278579, ECO:0000269|PubMed:15184369, ECO:0000269|PubMed:23612980, ECO:0000269|PubMed:29258289, ECO:0000269|PubMed:29861107}. |
| Q9H201 | EPN3 | S264 | ochoa | Epsin-3 (EPS-15-interacting protein 3) | None |
| Q9H2S1 | KCNN2 | S464 | psp | Small conductance calcium-activated potassium channel protein 2 (SK2) (SKCa 2) (SKCa2) (KCa2.2) | Small conductance calcium-activated potassium channel that mediates the voltage-independent transmembrane transfer of potassium across the cell membrane through a constitutive interaction with calmodulin which binds the intracellular calcium allowing its opening (PubMed:10991935, PubMed:33242881, PubMed:9287325). The current is characterized by a voltage-independent activation, an intracellular calcium concentration increase-dependent activation and a single-channel conductance of about 3 picosiemens (PubMed:10991935). Also presents an inwardly rectifying current, thus reducing its already small outward conductance of potassium ions, which is particularly the case when the membrane potential displays positive values, above + 20 mV (PubMed:10991935). The inward rectification could be due to a blockade of the outward current by intracellular divalent cations such as calcium and magnesium and could also be due to an intrinsic property of the channel pore, independent of intracellular divalent ions. There are three positively charged amino acids in the S6 transmembrane domain, close to the pore, that collectively control the conductance and rectification through an electrostatic mechanism. Additionally, electrostatic contributions from these residues also play an important role in determining the intrinsic open probability of the channel in the absence of calcium, affecting the apparent calcium affinity for activation. Forms an heteromeric complex with calmodulin, which is constitutively associated in a calcium-independent manner. Channel opening is triggered when calcium binds the calmodulin resulting in a rotary movement leading to the formation of the dimeric complex to open the gate (By similarity). Plays a role in the repolarization phase of cardiac action potential (PubMed:13679367). {ECO:0000250|UniProtKB:P70604, ECO:0000269|PubMed:10991935, ECO:0000269|PubMed:13679367, ECO:0000269|PubMed:33242881, ECO:0000269|PubMed:9287325}. |
| Q9H7P6 | MVB12B | S46 | psp | Multivesicular body subunit 12B (ESCRT-I complex subunit MVB12B) (Protein FAM125B) | Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. |
| Q9H7P9 | PLEKHG2 | S1289 | ochoa | Pleckstrin homology domain-containing family G member 2 (PH domain-containing family G member 2) | May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein) (PubMed:18045877). Involved in the regulation of actin polymerization (PubMed:26573021). {ECO:0000250|UniProtKB:Q6KAU7, ECO:0000269|PubMed:18045877, ECO:0000269|PubMed:26573021}. |
| Q9H8Y8 | GORASP2 | S189 | psp | Golgi reassembly-stacking protein 2 (GRS2) (Golgi phosphoprotein 6) (GOLPH6) (Golgi reassembly-stacking protein of 55 kDa) (GRASP55) (p59) | Key structural protein of the Golgi apparatus (PubMed:33301566). The membrane cisternae of the Golgi apparatus adhere to each other to form stacks, which are aligned side by side to form the Golgi ribbon (PubMed:33301566). Acting in concert with GORASP1/GRASP65, is required for the formation and maintenance of the Golgi ribbon, and may be dispensable for the formation of stacks (PubMed:33301566). However, other studies suggest that GORASP2 plays a role in the assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after breakdown during mitosis and meiosis (PubMed:10487747, PubMed:21515684, PubMed:22523075). May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane TGFA (PubMed:11101516). Required for normal acrosome formation during spermiogenesis and normal male fertility, probably by promoting colocalization of JAM2 and JAM3 at contact sites between germ cells and Sertoli cells (By similarity). Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (PubMed:21884936, PubMed:27062250, PubMed:28067262). {ECO:0000250|UniProtKB:Q99JX3, ECO:0000269|PubMed:10487747, ECO:0000269|PubMed:11101516, ECO:0000269|PubMed:21515684, ECO:0000269|PubMed:21884936, ECO:0000269|PubMed:22523075, ECO:0000269|PubMed:27062250, ECO:0000269|PubMed:28067262}. |
| Q9HCM7 | FBRSL1 | S340 | ochoa | Fibrosin-1-like protein (AUTS2-like protein) (HBV X-transactivated gene 9 protein) (HBV XAg-transactivated protein 9) | None |
| Q9NQA5 | TRPV5 | S144 | psp | Transient receptor potential cation channel subfamily V member 5 (TrpV5) (Calcium transport protein 2) (CaT2) (Epithelial calcium channel 1) (ECaC) (ECaC1) (Osm-9-like TRP channel 3) (OTRPC3) | Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine (PubMed:11549322, PubMed:18768590). Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules (By similarity). The channel is activated by low internal calcium level and the current exhibits an inward rectification (PubMed:11549322, PubMed:18768590). A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay (By similarity). Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity). {ECO:0000250|UniProtKB:P69744, ECO:0000250|UniProtKB:Q9XSM3, ECO:0000269|PubMed:11549322, ECO:0000269|PubMed:18768590}. |
| Q9NQX7 | ITM2C | S24 | ochoa | Integral membrane protein 2C (Cerebral protein 14) (Transmembrane protein BRI3) [Cleaved into: CT-BRI3] | Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity). {ECO:0000250, ECO:0000269|PubMed:18452648, ECO:0000269|PubMed:19366692}. |
| Q9NWV8 | BABAM1 | S47 | ochoa | BRISC and BRCA1-A complex member 1 (Mediator of RAP80 interactions and targeting subunit of 40 kDa) (New component of the BRCA1-A complex) | Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:24075985, PubMed:26195665). In these 2 complexes, it is probably required to maintain the stability of BABAM2 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). {ECO:0000269|PubMed:19261746, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19261749}. |
| Q9P265 | DIP2B | S75 | ochoa | Disco-interacting protein 2 homolog B (DIP2 homolog B) | Negatively regulates axonal outgrowth and is essential for normal synaptic transmission. Not required for regulation of axon polarity. Promotes acetylation of alpha-tubulin. {ECO:0000250|UniProtKB:Q3UH60}. |
| Q9UIF9 | BAZ2A | S361 | ochoa | Bromodomain adjacent to zinc finger domain protein 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3) | Regulatory subunit of the ATP-dependent NoRC-1 and NoRC-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Directly stimulates the ATPase activity of SMARCA5 in the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). The NoRC-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NoRC-5 ISWI chromatin remodeling complex, mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription (By similarity). Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac (By similarity). Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity). {ECO:0000250|UniProtKB:Q91YE5, ECO:0000269|PubMed:28801535}. |
| Q9UK32 | RPS6KA6 | S83 | ochoa | Ribosomal protein S6 kinase alpha-6 (S6K-alpha-6) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (p90RSK6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4) | Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. {ECO:0000269|PubMed:15042092, ECO:0000269|PubMed:15632195}. |
| Q9UPA5 | BSN | S2041 | ochoa | Protein bassoon (Zinc finger protein 231) | Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (PubMed:12812759). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (PubMed:19380881). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). Also functions in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy by associating with ATG5 (By similarity). Also mediates synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import (By similarity). Inhibits the activity of the proportion of DAO enzyme that localizes to the presynaptic active zone, which may modulate synaptic transmission (By similarity). {ECO:0000250|UniProtKB:O35078, ECO:0000250|UniProtKB:O88778, ECO:0000269|PubMed:12812759, ECO:0000269|PubMed:19380881}. |
| Q9UQ35 | SRRM2 | S2236 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y2H0 | DLGAP4 | S968 | ochoa | Disks large-associated protein 4 (DAP-4) (PSD-95/SAP90-binding protein 4) (SAP90/PSD-95-associated protein 4) (SAPAP-4) | May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane. |
| Q9Y2J4 | AMOTL2 | S670 | ochoa | Angiomotin-like protein 2 (Leman coiled-coil protein) (LCCP) | Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Plays a role in coupling actin fibers to cell junctions in endothelial cells and is therefore required for correct endothelial cell morphology via facilitating transcellular transmission of mechanical force resulting in endothelial cell elongation (By similarity). Required for the anchoring of radial actin fibers to CDH1 junction complexes at the cell membrane which facilitates organization of radial actin fiber structure and cellular response to contractile forces (PubMed:28842668). This contributes to maintenance of cell area, size, shape, epithelial sheet organization and trophectoderm cell properties that facilitate blastocyst zona hatching (PubMed:28842668). Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. Activates the Hippo signaling pathway in response to cell contact inhibition via interaction with and ubiquitination by Crumbs complex-bound WWP1 (PubMed:34404733). Ubiquitinated AMOTL2 then interacts with LATS2 which in turn phosphorylates YAP1, excluding it from the nucleus and localizing it to the cytoplasm and tight junctions, therefore ultimately repressing YAP1-driven transcription of target genes (PubMed:17293535, PubMed:21205866, PubMed:26598551). Acts to inhibit WWTR1/TAZ transcriptional coactivator activity via sequestering WWTR1/TAZ in the cytoplasm and at tight junctions (PubMed:23911299). Regulates the size and protein composition of the podosome cortex and core at myofibril neuromuscular junctions (PubMed:23525008). Selectively promotes FGF-induced MAPK activation through SRC (PubMed:17293535). May play a role in the polarity, proliferation and migration of endothelial cells. {ECO:0000250|UniProtKB:Q8K371, ECO:0000269|PubMed:17293535, ECO:0000269|PubMed:21205866, ECO:0000269|PubMed:21937427, ECO:0000269|PubMed:22362771, ECO:0000269|PubMed:23525008, ECO:0000269|PubMed:23911299, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:28842668, ECO:0000269|PubMed:34404733}. |
| Q9Y2Z0 | SUGT1 | S321 | ochoa|psp | Protein SGT1 homolog (Protein 40-6-3) (Sgt1) (Suppressor of G2 allele of SKP1 homolog) | May play a role in ubiquitination and subsequent proteasomal degradation of target proteins. |
| Q9Y490 | TLN1 | S814 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| Q06124 | PTPN11 | S134 | Sugiyama | Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3) | Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus (PubMed:10655584, PubMed:14739280, PubMed:18559669, PubMed:18829466, PubMed:26742426, PubMed:28074573). Positively regulates MAPK signal transduction pathway (PubMed:28074573). Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed:28074573). Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity (PubMed:18559669). Dephosphorylates CDC73 (PubMed:26742426). Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification (By similarity). Dephosphorylates tyrosine-phosphorylated NEDD9/CAS-L (PubMed:19275884). {ECO:0000250|UniProtKB:P35235, ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:14739280, ECO:0000269|PubMed:18559669, ECO:0000269|PubMed:18829466, ECO:0000269|PubMed:19275884, ECO:0000269|PubMed:26742426, ECO:0000269|PubMed:28074573}. |
| P78371 | CCT2 | S150 | Sugiyama | T-complex protein 1 subunit beta (TCP-1-beta) (EC 3.6.1.-) (CCT-beta) (Chaperonin containing T-complex polypeptide 1 subunit 2) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P49588 | AARS1 | S627 | Sugiyama | Alanine--tRNA ligase, cytoplasmic (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS) (Protein lactyltransferase AARS1) (EC 6.-.-.-) (Renal carcinoma antigen NY-REN-42) | Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala) (PubMed:27622773, PubMed:27911835, PubMed:28493438, PubMed:33909043). Also edits incorrectly charged tRNA(Ala) via its editing domain (PubMed:27622773, PubMed:27911835, PubMed:28493438, PubMed:29273753). In presence of high levels of lactate, also acts as a protein lactyltransferase that mediates lactylation of lysine residues in target proteins, such as TEAD1, TP53/p53 and YAP1 (PubMed:38512451, PubMed:38653238). Protein lactylation takes place in a two-step reaction: lactate is first activated by ATP to form lactate-AMP and then transferred to lysine residues of target proteins (PubMed:38512451, PubMed:38653238, PubMed:39322678). Acts as an inhibitor of TP53/p53 activity by catalyzing lactylation of TP53/p53 (PubMed:38653238). Acts as a positive regulator of the Hippo pathway by mediating lactylation of TEAD1 and YAP1 (PubMed:38512451). {ECO:0000269|PubMed:27622773, ECO:0000269|PubMed:27911835, ECO:0000269|PubMed:28493438, ECO:0000269|PubMed:29273753, ECO:0000269|PubMed:33909043, ECO:0000269|PubMed:38512451, ECO:0000269|PubMed:38653238, ECO:0000269|PubMed:39322678}. |
| P06733 | ENO1 | S349 | Sugiyama | Alpha-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (C-myc promoter-binding protein) (Enolase 1) (MBP-1) (MPB-1) (Non-neural enolase) (NNE) (Phosphopyruvate hydratase) (Plasminogen-binding protein) | Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (PubMed:1369209, PubMed:29775581). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses (PubMed:10802057, PubMed:12666133, PubMed:2005901, PubMed:29775581). May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (PubMed:12666133). Stimulates immunoglobulin production (PubMed:1369209). {ECO:0000269|PubMed:10802057, ECO:0000269|PubMed:12666133, ECO:0000269|PubMed:1369209, ECO:0000269|PubMed:2005901, ECO:0000269|PubMed:29775581}.; FUNCTION: [Isoform MBP-1]: Binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor. {ECO:0000269|PubMed:10082554}. |
| O15357 | INPPL1 | S43 | Sugiyama | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (Protein 51C) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2) | Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:16824732). Required for correct mitotic spindle orientation and therefore progression of mitosis (By similarity). Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear (PubMed:9660833). While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking (By similarity). Confers resistance to dietary obesity (By similarity). May act by regulating AKT2, but not AKT1, phosphorylation at the plasma membrane (By similarity). Part of a signaling pathway that regulates actin cytoskeleton remodeling (PubMed:11739414, PubMed:12676785). Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation (PubMed:15668240). Participates in regulation of cortical and submembraneous actin by hydrolyzing PtdIns(3,4,5)P3 thereby regulating membrane ruffling (PubMed:21624956). Regulates cell adhesion and cell spreading (PubMed:12235291). Required for HGF-mediated lamellipodium formation, cell scattering and spreading (PubMed:15735664). Acts as a negative regulator of EPHA2 receptor endocytosis by inhibiting via PI3K-dependent Rac1 activation (PubMed:17135240). Acts as a regulator of neuritogenesis by regulating PtdIns(3,4,5)P3 level and is required to form an initial protrusive pattern, and later, maintain proper neurite outgrowth (By similarity). Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A) (PubMed:12690104). Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems (PubMed:11016922). Involved in EGF signaling pathway (PubMed:11349134). Upon stimulation by EGF, it is recruited by EGFR and dephosphorylates PtdIns(3,4,5)P3 (PubMed:11349134). Plays a negative role in regulating the PI3K-PKB pathway, possibly by inhibiting PKB activity (PubMed:11349134). Down-regulates Fc-gamma-R-mediated phagocytosis in macrophages independently of INPP5D/SHIP1 (By similarity). In macrophages, down-regulates NF-kappa-B-dependent gene transcription by regulating macrophage colony-stimulating factor (M-CSF)-induced signaling (By similarity). Plays a role in the localization of AURKA and NEDD9/HEF1 to the basolateral membrane at interphase in polarized cysts, thereby mediates cell cycle homeostasis, cell polarization and cilia assembly (By similarity). Additionally promotion of cilia growth is also facilitated by hydrolysis of (PtdIns(3,4,5)P3) to PtdIns(3,4)P2 (By similarity). Promotes formation of apical membrane-initiation sites during the initial stages of lumen formation via Rho family-induced actin filament organization and CTNNB1 localization to cell-cell contacts (By similarity). May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6. Involved in endochondral ossification (PubMed:23273569). {ECO:0000250|UniProtKB:F1PNY0, ECO:0000250|UniProtKB:Q6P549, ECO:0000250|UniProtKB:Q9WVR3, ECO:0000269|PubMed:11016922, ECO:0000269|PubMed:11349134, ECO:0000269|PubMed:11739414, ECO:0000269|PubMed:12235291, ECO:0000269|PubMed:12676785, ECO:0000269|PubMed:12690104, ECO:0000269|PubMed:15668240, ECO:0000269|PubMed:15735664, ECO:0000269|PubMed:16824732, ECO:0000269|PubMed:17135240, ECO:0000269|PubMed:21624956, ECO:0000269|PubMed:23273569, ECO:0000269|PubMed:9660833}. |
| P29401 | TKT | S548 | Sugiyama | Transketolase (TK) (EC 2.2.1.1) | Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. {ECO:0000269|PubMed:27259054}. |
| Q99426 | TBCB | S163 | Sugiyama | Tubulin-folding cofactor B (Cytoskeleton-associated protein 1) (Cytoskeleton-associated protein CKAPI) (Tubulin-specific chaperone B) | Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer (PubMed:9265649). Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth (By similarity). {ECO:0000250|UniProtKB:Q9D1E6, ECO:0000269|PubMed:9265649}. |
| O00115 | DNASE2 | S57 | Sugiyama | Deoxyribonuclease-2-alpha (EC 3.1.22.1) (Acid DNase) (Deoxyribonuclease II alpha) (DNase II alpha) (Lysosomal DNase II) (R31240_2) | Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the clearance of nucleic acids generated through apoptosis, hence preventing autoinflammation (PubMed:29259162, PubMed:31775019). Necessary for proper fetal development and for definitive erythropoiesis in fetal liver and bone marrow, where it degrades nuclear DNA expelled from erythroid precursor cells (PubMed:29259162). {ECO:0000269|PubMed:29259162, ECO:0000269|PubMed:31775019}. |
| P33316 | DUT | S130 | Sugiyama | Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase) | Catalyzes the cleavage of 2'-deoxyuridine 5'-triphosphate (dUTP) into 2'-deoxyuridine 5'-monophosphate (dUMP) and inorganic pyrophosphate and through its action efficiently prevents uracil misincorporation into DNA and at the same time provides dUMP, the substrate for de novo thymidylate biosynthesis (PubMed:17880943, PubMed:8631816, PubMed:8805593). Inhibits peroxisome proliferator-activated receptor (PPAR) activity by binding of its N-terminal to PPAR, preventing the latter's dimerization with retinoid X receptor (By similarity). Essential for embryonic development (By similarity). {ECO:0000250|UniProtKB:P70583, ECO:0000250|UniProtKB:Q9CQ43, ECO:0000269|PubMed:17880943, ECO:0000269|PubMed:8631816, ECO:0000269|PubMed:8805593}. |
| P35408 | PTGER4 | S460 | ELM | Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor) | Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function. |
| P61221 | ABCE1 | S186 | Sugiyama | ATP-binding cassette sub-family E member 1 (EC 3.6.5.-) (2'-5'-oligoadenylate-binding protein) (HuHP68) (RNase L inhibitor) (Ribonuclease 4 inhibitor) (RNS4I) | Nucleoside-triphosphatase (NTPase) involved in ribosome recycling by mediating ribosome disassembly (PubMed:20122402, PubMed:21448132). Able to hydrolyze ATP, GTP, UTP and CTP (PubMed:20122402). Splits ribosomes into free 60S subunits and tRNA- and mRNA-bound 40S subunits (PubMed:20122402, PubMed:21448132). Acts either after canonical termination facilitated by release factors (ETF1/eRF1) or after recognition of stalled and vacant ribosomes by mRNA surveillance factors (PELO/Pelota) (PubMed:20122402, PubMed:21448132). Involved in the No-Go Decay (NGD) pathway: recruited to stalled ribosomes by the Pelota-HBS1L complex, and drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (PubMed:21448132). Also plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA (PubMed:29861391). As part of the PINK1-regulated signaling, ubiquitinated by CNOT4 upon mitochondria damage; this modification generates polyubiquitin signals that recruit autophagy receptors to the mitochondrial outer membrane and initiate mitophagy (PubMed:29861391). RNASEL-specific protein inhibitor which antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) to RNASEL (PubMed:9660177). Negative regulator of the anti-viral effect of the interferon-regulated 2-5A/RNASEL pathway (PubMed:11585831, PubMed:9660177, PubMed:9847332). {ECO:0000269|PubMed:11585831, ECO:0000269|PubMed:20122402, ECO:0000269|PubMed:21448132, ECO:0000269|PubMed:29861391, ECO:0000269|PubMed:9660177, ECO:0000269|PubMed:9847332}.; FUNCTION: (Microbial infection) May act as a chaperone for post-translational events during HIV-1 capsid assembly. {ECO:0000269|PubMed:9847332}.; FUNCTION: (Microbial infection) Plays a role in the down-regulation of the 2-5A/RNASEL pathway during encephalomyocarditis virus (EMCV) and HIV-1 infections. {ECO:0000269|PubMed:9660177}. |
| P08195 | SLC3A2 | S286 | Sugiyama | Amino acid transporter heavy chain SLC3A2 (4F2 cell-surface antigen heavy chain) (4F2hc) (4F2 heavy chain antigen) (Lymphocyte activation antigen 4F2 large subunit) (Solute carrier family 3 member 2) (CD antigen CD98) | Acts as a chaperone that facilitates biogenesis and trafficking of functional transporters heterodimers to the plasma membrane. Forms heterodimer with SLC7 family transporters (SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A10 and SLC7A11), a group of amino-acid antiporters (PubMed:10574970, PubMed:10903140, PubMed:11557028, PubMed:30867591, PubMed:33298890, PubMed:33758168, PubMed:34880232, PubMed:9751058, PubMed:9829974, PubMed:9878049). Heterodimers function as amino acids exchangers, the specificity of the substrate depending on the SLC7A subunit. Heterodimers SLC3A2/SLC7A6 or SLC3A2/SLC7A7 mediate the uptake of dibasic amino acids (PubMed:10903140, PubMed:9829974). Heterodimer SLC3A2/SLC7A11 functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane (PubMed:34880232). SLC3A2/SLC7A10 translocates small neutral L- and D-amino acids across the plasma membrane (By similarity). SLC3A2/SLC75 or SLC3A2/SLC7A8 translocates neutral amino acids with broad specificity, thyroid hormones and L-DOPA (PubMed:10574970, PubMed:11389679, PubMed:11557028, PubMed:11564694, PubMed:11742812, PubMed:12117417, PubMed:12225859, PubMed:12716892, PubMed:15980244, PubMed:30867591, PubMed:33298890, PubMed:33758168). SLC3A2 is essential for plasma membrane localization, stability, and the transport activity of SLC7A5 and SLC7A8 (PubMed:10391915, PubMed:10574970, PubMed:11311135, PubMed:15769744, PubMed:33066406). When associated with LAPTM4B, the heterodimer SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation (PubMed:25998567). Modulates integrin-related signaling and is essential for integrin-dependent cell spreading, migration and tumor progression (PubMed:11121428, PubMed:15625115). {ECO:0000250|UniProtKB:P63115, ECO:0000269|PubMed:10391915, ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:10903140, ECO:0000269|PubMed:11121428, ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:11389679, ECO:0000269|PubMed:11557028, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:11742812, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:12716892, ECO:0000269|PubMed:15625115, ECO:0000269|PubMed:15769744, ECO:0000269|PubMed:15980244, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:33066406, ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:33758168, ECO:0000269|PubMed:34880232, ECO:0000269|PubMed:9751058, ECO:0000269|PubMed:9829974, ECO:0000269|PubMed:9878049}.; FUNCTION: (Microbial infection) In case of hepatitis C virus/HCV infection, the complex formed by SLC3A2 and SLC7A5/LAT1 plays a role in HCV propagation by facilitating viral entry into host cell and increasing L-leucine uptake-mediated mTORC1 signaling activation, thereby contributing to HCV-mediated pathogenesis. {ECO:0000269|PubMed:30341327}.; FUNCTION: (Microbial infection) Acts as a receptor for malaria parasite Plasmodium vivax (Thai isolate) in immature red blood cells. {ECO:0000269|PubMed:34294905}. |
| P51957 | NEK4 | S772 | Sugiyama | Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) | Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage. {ECO:0000250|UniProtKB:Q9Z1J2, ECO:0000269|PubMed:22851694}. |
| P18206 | VCL | S1002 | Sugiyama | Vinculin (Metavinculin) (MV) | Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. {ECO:0000269|PubMed:20484056}. |
| Q06124 | PTPN11 | S28 | Sugiyama | Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3) | Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus (PubMed:10655584, PubMed:14739280, PubMed:18559669, PubMed:18829466, PubMed:26742426, PubMed:28074573). Positively regulates MAPK signal transduction pathway (PubMed:28074573). Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed:28074573). Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity (PubMed:18559669). Dephosphorylates CDC73 (PubMed:26742426). Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification (By similarity). Dephosphorylates tyrosine-phosphorylated NEDD9/CAS-L (PubMed:19275884). {ECO:0000250|UniProtKB:P35235, ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:14739280, ECO:0000269|PubMed:18559669, ECO:0000269|PubMed:18829466, ECO:0000269|PubMed:19275884, ECO:0000269|PubMed:26742426, ECO:0000269|PubMed:28074573}. |
| Q8NG66 | NEK11 | S39 | Sugiyama | Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (Never in mitosis A-related kinase 11) (NimA-related protein kinase 11) | Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation. {ECO:0000269|PubMed:12154088, ECO:0000269|PubMed:19734889, ECO:0000269|PubMed:20090422}. |
| P00966 | ASS1 | S131 | Sugiyama | Argininosuccinate synthase (EC 6.3.4.5) (Citrulline--aspartate ligase) | One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues. {ECO:0000305|PubMed:18473344, ECO:0000305|PubMed:27287393, ECO:0000305|PubMed:8792870}. |
| Q9H6T3 | RPAP3 | S348 | Sugiyama | RNA polymerase II-associated protein 3 | Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. {ECO:0000269|PubMed:17643375}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 2.779320e-07 | 6.556 |
| R-HSA-68875 | Mitotic Prophase | 7.618054e-05 | 4.118 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 2.078585e-04 | 3.682 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 2.463315e-04 | 3.608 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 4.804093e-04 | 3.318 |
| R-HSA-445355 | Smooth Muscle Contraction | 4.281735e-04 | 3.368 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 7.348469e-04 | 3.134 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 1.028204e-03 | 2.988 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 1.535485e-03 | 2.814 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 1.779910e-03 | 2.750 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 2.673058e-03 | 2.573 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 2.369970e-03 | 2.625 |
| R-HSA-912446 | Meiotic recombination | 3.217718e-03 | 2.492 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 3.262815e-03 | 2.486 |
| R-HSA-109582 | Hemostasis | 3.468922e-03 | 2.460 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 4.777543e-03 | 2.321 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 4.777543e-03 | 2.321 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 4.772533e-03 | 2.321 |
| R-HSA-422475 | Axon guidance | 5.258644e-03 | 2.279 |
| R-HSA-444257 | RSK activation | 5.727178e-03 | 2.242 |
| R-HSA-5334118 | DNA methylation | 5.616892e-03 | 2.251 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 7.546800e-03 | 2.122 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 7.089780e-03 | 2.149 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 7.454573e-03 | 2.128 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 6.770948e-03 | 2.169 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 7.546800e-03 | 2.122 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 6.608519e-03 | 2.180 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 6.766309e-03 | 2.170 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 1.044861e-02 | 1.981 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 8.641089e-03 | 2.063 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 1.044861e-02 | 1.981 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 8.860508e-03 | 2.053 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 9.246182e-03 | 2.034 |
| R-HSA-210990 | PECAM1 interactions | 9.095223e-03 | 2.041 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 1.037238e-02 | 1.984 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 1.004999e-02 | 1.998 |
| R-HSA-114604 | GPVI-mediated activation cascade | 9.823732e-03 | 2.008 |
| R-HSA-9675108 | Nervous system development | 8.710531e-03 | 2.060 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 9.558486e-03 | 2.020 |
| R-HSA-9020591 | Interleukin-12 signaling | 1.089783e-02 | 1.963 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 1.317523e-02 | 1.880 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 1.317523e-02 | 1.880 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 1.272894e-02 | 1.895 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 1.245926e-02 | 1.905 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 1.172403e-02 | 1.931 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 1.272894e-02 | 1.895 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 1.149952e-02 | 1.939 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 1.256398e-02 | 1.901 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 1.391426e-02 | 1.857 |
| R-HSA-5674135 | MAP2K and MAPK activation | 1.391426e-02 | 1.857 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 1.627060e-02 | 1.789 |
| R-HSA-1500620 | Meiosis | 1.527981e-02 | 1.816 |
| R-HSA-171007 | p38MAPK events | 1.620993e-02 | 1.790 |
| R-HSA-9710421 | Defective pyroptosis | 1.546187e-02 | 1.811 |
| R-HSA-438064 | Post NMDA receptor activation events | 1.695429e-02 | 1.771 |
| R-HSA-114608 | Platelet degranulation | 1.530302e-02 | 1.815 |
| R-HSA-2559583 | Cellular Senescence | 1.640759e-02 | 1.785 |
| R-HSA-447115 | Interleukin-12 family signaling | 1.695429e-02 | 1.771 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 1.795825e-02 | 1.746 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 1.795825e-02 | 1.746 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 1.795825e-02 | 1.746 |
| R-HSA-6802949 | Signaling by RAS mutants | 1.795825e-02 | 1.746 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 1.841567e-02 | 1.735 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 1.883727e-02 | 1.725 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 1.954409e-02 | 1.709 |
| R-HSA-389356 | Co-stimulation by CD28 | 1.973980e-02 | 1.705 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 2.196526e-02 | 1.658 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 2.036918e-02 | 1.691 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 2.115693e-02 | 1.675 |
| R-HSA-68886 | M Phase | 2.224211e-02 | 1.653 |
| R-HSA-3928664 | Ephrin signaling | 2.313903e-02 | 1.636 |
| R-HSA-6794361 | Neurexins and neuroligins | 2.358540e-02 | 1.627 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 2.358540e-02 | 1.627 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 2.460570e-02 | 1.609 |
| R-HSA-156711 | Polo-like kinase mediated events | 2.313903e-02 | 1.636 |
| R-HSA-9831926 | Nephron development | 2.313903e-02 | 1.636 |
| R-HSA-389948 | Co-inhibition by PD-1 | 2.479607e-02 | 1.606 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 2.698307e-02 | 1.569 |
| R-HSA-844456 | The NLRP3 inflammasome | 2.503062e-02 | 1.602 |
| R-HSA-8953897 | Cellular responses to stimuli | 2.743989e-02 | 1.562 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 2.625911e-02 | 1.581 |
| R-HSA-373753 | Nephrin family interactions | 2.698307e-02 | 1.569 |
| R-HSA-166520 | Signaling by NTRKs | 2.763782e-02 | 1.558 |
| R-HSA-193648 | NRAGE signals death through JNK | 2.780778e-02 | 1.556 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 3.968544e-02 | 1.401 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 3.968544e-02 | 1.401 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 3.968544e-02 | 1.401 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 3.968544e-02 | 1.401 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 3.968544e-02 | 1.401 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 3.968544e-02 | 1.401 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 3.968544e-02 | 1.401 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 3.968544e-02 | 1.401 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 3.968544e-02 | 1.401 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 3.968544e-02 | 1.401 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 3.968544e-02 | 1.401 |
| R-HSA-8865999 | MET activates PTPN11 | 4.935972e-02 | 1.307 |
| R-HSA-5660862 | Defective SLC7A7 causes lysinuric protein intolerance (LPI) | 4.935972e-02 | 1.307 |
| R-HSA-1251932 | PLCG1 events in ERBB2 signaling | 5.893714e-02 | 1.230 |
| R-HSA-1306955 | GRB7 events in ERBB2 signaling | 5.893714e-02 | 1.230 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 7.780522e-02 | 1.109 |
| R-HSA-9645135 | STAT5 Activation | 8.709778e-02 | 1.060 |
| R-HSA-69478 | G2/M DNA replication checkpoint | 8.709778e-02 | 1.060 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 8.709778e-02 | 1.060 |
| R-HSA-9732724 | IFNG signaling activates MAPKs | 9.629728e-02 | 1.016 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 9.629728e-02 | 1.016 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 1.054046e-01 | 0.977 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 1.054046e-01 | 0.977 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 1.233466e-01 | 0.909 |
| R-HSA-451308 | Activation of Ca-permeable Kainate Receptor | 1.233466e-01 | 0.909 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 1.495910e-01 | 0.825 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 1.666520e-01 | 0.778 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 1.750545e-01 | 0.757 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 1.833728e-01 | 0.737 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 1.916077e-01 | 0.718 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 1.997601e-01 | 0.699 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 1.997601e-01 | 0.699 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 2.078307e-01 | 0.682 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 2.158205e-01 | 0.666 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 3.867450e-02 | 1.413 |
| R-HSA-163210 | Formation of ATP by chemiosmotic coupling | 2.237302e-01 | 0.650 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 4.551433e-02 | 1.342 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 2.393124e-01 | 0.621 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 2.393124e-01 | 0.621 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 5.488023e-02 | 1.261 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 5.488023e-02 | 1.261 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 7.974146e-02 | 1.098 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 1.581645e-01 | 0.801 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 5.488023e-02 | 1.261 |
| R-HSA-3214842 | HDMs demethylate histones | 3.989857e-02 | 1.399 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 6.930943e-02 | 1.159 |
| R-HSA-3371568 | Attenuation phase | 8.271405e-02 | 1.082 |
| R-HSA-3214815 | HDACs deacetylate histones | 1.342270e-01 | 0.872 |
| R-HSA-2682334 | EPH-Ephrin signaling | 8.578632e-02 | 1.067 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 1.079343e-01 | 0.967 |
| R-HSA-163615 | PKA activation | 2.078307e-01 | 0.682 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 8.271405e-02 | 1.082 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 3.122093e-02 | 1.506 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 1.143264e-01 | 0.942 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 1.143264e-01 | 0.942 |
| R-HSA-163754 | Insulin effects increased synthesis of Xylulose-5-Phosphate | 9.629728e-02 | 1.016 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 3.760972e-02 | 1.425 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 2.469865e-01 | 0.607 |
| R-HSA-3371571 | HSF1-dependent transactivation | 1.207423e-01 | 0.918 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 4.271071e-02 | 1.369 |
| R-HSA-5693606 | DNA Double Strand Break Response | 4.134263e-02 | 1.384 |
| R-HSA-3214847 | HATs acetylate histones | 1.016880e-01 | 0.993 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 1.495910e-01 | 0.825 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 1.365425e-01 | 0.865 |
| R-HSA-9636667 | Manipulation of host energy metabolism | 2.991331e-02 | 1.524 |
| R-HSA-176417 | Phosphorylation of Emi1 | 7.780522e-02 | 1.109 |
| R-HSA-9032845 | Activated NTRK2 signals through CDK5 | 9.629728e-02 | 1.016 |
| R-HSA-9927354 | Co-stimulation by ICOS | 1.054046e-01 | 0.977 |
| R-HSA-451306 | Ionotropic activity of kainate receptors | 1.321830e-01 | 0.879 |
| R-HSA-209560 | NF-kB is activated and signals survival | 1.409308e-01 | 0.851 |
| R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer | 1.495910e-01 | 0.825 |
| R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants | 1.495910e-01 | 0.825 |
| R-HSA-174490 | Membrane binding and targetting of GAG proteins | 1.581645e-01 | 0.801 |
| R-HSA-162588 | Budding and maturation of HIV virion | 5.466962e-02 | 1.262 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 1.750545e-01 | 0.757 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 6.266852e-02 | 1.203 |
| R-HSA-176412 | Phosphorylation of the APC/C | 1.833728e-01 | 0.737 |
| R-HSA-9702518 | STAT5 activation downstream of FLT3 ITD mutants | 1.916077e-01 | 0.718 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 3.240533e-02 | 1.489 |
| R-HSA-164378 | PKA activation in glucagon signalling | 2.078307e-01 | 0.682 |
| R-HSA-392451 | G beta:gamma signalling through PI3Kgamma | 2.545837e-01 | 0.594 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 2.545837e-01 | 0.594 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 9.837836e-02 | 1.007 |
| R-HSA-1433557 | Signaling by SCF-KIT | 9.493110e-02 | 1.023 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 9.182974e-02 | 1.037 |
| R-HSA-180292 | GAB1 signalosome | 2.078307e-01 | 0.682 |
| R-HSA-5654710 | PI-3K cascade:FGFR3 | 2.158205e-01 | 0.666 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 2.237302e-01 | 0.650 |
| R-HSA-5654720 | PI-3K cascade:FGFR4 | 2.237302e-01 | 0.650 |
| R-HSA-111931 | PKA-mediated phosphorylation of CREB | 2.315605e-01 | 0.635 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 4.694964e-02 | 1.328 |
| R-HSA-5654689 | PI-3K cascade:FGFR1 | 2.469865e-01 | 0.607 |
| R-HSA-418885 | DCC mediated attractive signaling | 1.750545e-01 | 0.757 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 2.388984e-01 | 0.622 |
| R-HSA-9013700 | NOTCH4 Activation and Transmission of Signal to the Nucleus | 1.144208e-01 | 0.941 |
| R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 1.666520e-01 | 0.778 |
| R-HSA-9837999 | Mitochondrial protein degradation | 8.965520e-02 | 1.047 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 6.930943e-02 | 1.159 |
| R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 2.315605e-01 | 0.635 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 9.682851e-02 | 1.014 |
| R-HSA-1433559 | Regulation of KIT signaling | 1.666520e-01 | 0.778 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 2.078307e-01 | 0.682 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 5.147730e-02 | 1.288 |
| R-HSA-3214858 | RMTs methylate histone arginines | 9.806232e-02 | 1.008 |
| R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 7.780522e-02 | 1.109 |
| R-HSA-1296052 | Ca2+ activated K+ channels | 9.629728e-02 | 1.016 |
| R-HSA-112411 | MAPK1 (ERK2) activation | 1.144208e-01 | 0.941 |
| R-HSA-442720 | CREB1 phosphorylation through the activation of Adenylate Cyclase | 1.581645e-01 | 0.801 |
| R-HSA-5635838 | Activation of SMO | 1.833728e-01 | 0.737 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 2.078307e-01 | 0.682 |
| R-HSA-5654706 | FRS-mediated FGFR3 signaling | 2.393124e-01 | 0.621 |
| R-HSA-5654712 | FRS-mediated FGFR4 signaling | 2.469865e-01 | 0.607 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 3.446473e-02 | 1.463 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 2.051598e-01 | 0.688 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 1.032148e-01 | 0.986 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 2.858198e-02 | 1.544 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 8.709778e-02 | 1.060 |
| R-HSA-9028731 | Activated NTRK2 signals through FRS2 and FRS3 | 1.495910e-01 | 0.825 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 5.147730e-02 | 1.288 |
| R-HSA-418555 | G alpha (s) signalling events | 1.281864e-01 | 0.892 |
| R-HSA-9669938 | Signaling by KIT in disease | 2.469865e-01 | 0.607 |
| R-HSA-877300 | Interferon gamma signaling | 1.063003e-01 | 0.973 |
| R-HSA-9706374 | FLT3 signaling through SRC family kinases | 5.893714e-02 | 1.230 |
| R-HSA-447038 | NrCAM interactions | 6.841866e-02 | 1.165 |
| R-HSA-9927353 | Co-inhibition by BTLA | 6.841866e-02 | 1.165 |
| R-HSA-9667769 | Acetylcholine inhibits contraction of outer hair cells | 7.780522e-02 | 1.109 |
| R-HSA-5660668 | CLEC7A/inflammasome pathway | 7.780522e-02 | 1.109 |
| R-HSA-199920 | CREB phosphorylation | 8.709778e-02 | 1.060 |
| R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 | 8.709778e-02 | 1.060 |
| R-HSA-418886 | Netrin mediated repulsion signals | 9.629728e-02 | 1.016 |
| R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 1.144208e-01 | 0.941 |
| R-HSA-110056 | MAPK3 (ERK1) activation | 1.233466e-01 | 0.909 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 1.409308e-01 | 0.851 |
| R-HSA-70635 | Urea cycle | 4.223891e-02 | 1.374 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 1.495910e-01 | 0.825 |
| R-HSA-877312 | Regulation of IFNG signaling | 1.495910e-01 | 0.825 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 2.158205e-01 | 0.666 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 9.182974e-02 | 1.037 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 2.393124e-01 | 0.621 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 2.095773e-01 | 0.679 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 1.144208e-01 | 0.941 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 5.729319e-02 | 1.242 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 2.158205e-01 | 0.666 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 2.237302e-01 | 0.650 |
| R-HSA-111933 | Calmodulin induced events | 7.103542e-02 | 1.149 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 1.044107e-01 | 0.981 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 1.044107e-01 | 0.981 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 6.541805e-02 | 1.184 |
| R-HSA-5683057 | MAPK family signaling cascades | 1.699015e-01 | 0.770 |
| R-HSA-111997 | CaM pathway | 7.103542e-02 | 1.149 |
| R-HSA-8939211 | ESR-mediated signaling | 1.211807e-01 | 0.917 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 6.841866e-02 | 1.165 |
| R-HSA-2660825 | Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | 7.780522e-02 | 1.109 |
| R-HSA-2660826 | Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | 7.780522e-02 | 1.109 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 7.780522e-02 | 1.109 |
| R-HSA-164944 | Nef and signal transduction | 8.709778e-02 | 1.060 |
| R-HSA-167590 | Nef Mediated CD4 Down-regulation | 9.629728e-02 | 1.016 |
| R-HSA-448706 | Interleukin-1 processing | 1.144208e-01 | 0.941 |
| R-HSA-193692 | Regulated proteolysis of p75NTR | 1.144208e-01 | 0.941 |
| R-HSA-167044 | Signalling to RAS | 2.899496e-02 | 1.538 |
| R-HSA-5682910 | LGI-ADAM interactions | 1.321830e-01 | 0.879 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 1.581645e-01 | 0.801 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 1.750545e-01 | 0.757 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 2.237302e-01 | 0.650 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 4.840713e-02 | 1.315 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 5.445625e-02 | 1.264 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 2.469865e-01 | 0.607 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 2.469865e-01 | 0.607 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 6.757660e-02 | 1.170 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 6.081611e-02 | 1.216 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 2.394632e-01 | 0.621 |
| R-HSA-111996 | Ca-dependent events | 9.182974e-02 | 1.037 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 2.078307e-01 | 0.682 |
| R-HSA-1474165 | Reproduction | 6.204268e-02 | 1.207 |
| R-HSA-622312 | Inflammasomes | 4.706904e-02 | 1.327 |
| R-HSA-1489509 | DAG and IP3 signaling | 1.012225e-01 | 0.995 |
| R-HSA-159418 | Recycling of bile acids and salts | 5.995986e-02 | 1.222 |
| R-HSA-373752 | Netrin-1 signaling | 9.806232e-02 | 1.008 |
| R-HSA-112316 | Neuronal System | 2.281443e-01 | 0.642 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 1.480306e-01 | 0.830 |
| R-HSA-71262 | Carnitine synthesis | 1.833728e-01 | 0.737 |
| R-HSA-9845576 | Glycosphingolipid transport | 7.103542e-02 | 1.149 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 2.469865e-01 | 0.607 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 2.545837e-01 | 0.594 |
| R-HSA-69481 | G2/M Checkpoints | 5.721507e-02 | 1.242 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 1.764132e-01 | 0.753 |
| R-HSA-69278 | Cell Cycle, Mitotic | 7.618515e-02 | 1.118 |
| R-HSA-1640170 | Cell Cycle | 3.483303e-02 | 1.458 |
| R-HSA-112043 | PLC beta mediated events | 1.550374e-01 | 0.810 |
| R-HSA-193639 | p75NTR signals via NF-kB | 1.750545e-01 | 0.757 |
| R-HSA-9659379 | Sensory processing of sound | 2.203238e-01 | 0.657 |
| R-HSA-1059683 | Interleukin-6 signaling | 1.581645e-01 | 0.801 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 1.113270e-01 | 0.953 |
| R-HSA-9010642 | ROBO receptors bind AKAP5 | 1.054046e-01 | 0.977 |
| R-HSA-3295583 | TRP channels | 4.223891e-02 | 1.374 |
| R-HSA-1170546 | Prolactin receptor signaling | 1.666520e-01 | 0.778 |
| R-HSA-9856872 | Malate-aspartate shuttle | 1.666520e-01 | 0.778 |
| R-HSA-196783 | Coenzyme A biosynthesis | 1.916077e-01 | 0.718 |
| R-HSA-392517 | Rap1 signalling | 2.158205e-01 | 0.666 |
| R-HSA-198753 | ERK/MAPK targets | 2.315605e-01 | 0.635 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 2.393124e-01 | 0.621 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 2.469865e-01 | 0.607 |
| R-HSA-975578 | Reactions specific to the complex N-glycan synthesis pathway | 2.469865e-01 | 0.607 |
| R-HSA-73864 | RNA Polymerase I Transcription | 5.761037e-02 | 1.239 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 1.299435e-01 | 0.886 |
| R-HSA-1266738 | Developmental Biology | 3.960354e-02 | 1.402 |
| R-HSA-9607240 | FLT3 Signaling | 8.572027e-02 | 1.067 |
| R-HSA-8983711 | OAS antiviral response | 1.495910e-01 | 0.825 |
| R-HSA-2028269 | Signaling by Hippo | 1.997601e-01 | 0.699 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 4.462948e-02 | 1.350 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 1.833728e-01 | 0.737 |
| R-HSA-422085 | Synthesis, secretion, and deacylation of Ghrelin | 2.315605e-01 | 0.635 |
| R-HSA-175474 | Assembly Of The HIV Virion | 2.393124e-01 | 0.621 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 1.079343e-01 | 0.967 |
| R-HSA-112040 | G-protein mediated events | 1.764132e-01 | 0.753 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 8.572027e-02 | 1.067 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 6.250019e-02 | 1.204 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 1.376498e-01 | 0.861 |
| R-HSA-397014 | Muscle contraction | 8.805269e-02 | 1.055 |
| R-HSA-391908 | Prostanoid ligand receptors | 1.321830e-01 | 0.879 |
| R-HSA-432142 | Platelet sensitization by LDL | 2.078307e-01 | 0.682 |
| R-HSA-163685 | Integration of energy metabolism | 2.029251e-01 | 0.693 |
| R-HSA-162582 | Signal Transduction | 9.452910e-02 | 1.024 |
| R-HSA-8953854 | Metabolism of RNA | 2.508594e-01 | 0.601 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 1.656636e-01 | 0.781 |
| R-HSA-2586552 | Signaling by Leptin | 1.233466e-01 | 0.909 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 9.182974e-02 | 1.037 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 1.054046e-01 | 0.977 |
| R-HSA-210991 | Basigin interactions | 2.899496e-02 | 1.538 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 3.106492e-02 | 1.508 |
| R-HSA-391160 | Signal regulatory protein family interactions | 1.666520e-01 | 0.778 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 1.750545e-01 | 0.757 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 2.545837e-01 | 0.594 |
| R-HSA-2262752 | Cellular responses to stress | 6.256074e-02 | 1.204 |
| R-HSA-446652 | Interleukin-1 family signaling | 2.478802e-01 | 0.606 |
| R-HSA-373755 | Semaphorin interactions | 1.621070e-01 | 0.790 |
| R-HSA-196757 | Metabolism of folate and pterines | 7.390114e-02 | 1.131 |
| R-HSA-69620 | Cell Cycle Checkpoints | 1.528843e-01 | 0.816 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 4.836759e-02 | 1.315 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 1.750545e-01 | 0.757 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 1.916077e-01 | 0.718 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 1.585647e-01 | 0.800 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 6.820738e-02 | 1.166 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 8.771165e-02 | 1.057 |
| R-HSA-8853659 | RET signaling | 7.103542e-02 | 1.149 |
| R-HSA-8956320 | Nucleotide biosynthesis | 1.274418e-01 | 0.895 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 8.199108e-02 | 1.086 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 1.872694e-01 | 0.728 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 1.275256e-01 | 0.894 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 7.640799e-02 | 1.117 |
| R-HSA-1266695 | Interleukin-7 signaling | 3.989857e-02 | 1.399 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 1.275256e-01 | 0.894 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 1.211807e-01 | 0.917 |
| R-HSA-8848021 | Signaling by PTK6 | 1.621070e-01 | 0.790 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 1.621070e-01 | 0.790 |
| R-HSA-9008059 | Interleukin-37 signaling | 5.209030e-02 | 1.283 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 3.240533e-02 | 1.489 |
| R-HSA-210993 | Tie2 Signaling | 2.078307e-01 | 0.682 |
| R-HSA-437239 | Recycling pathway of L1 | 1.076261e-01 | 0.968 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 2.469865e-01 | 0.607 |
| R-HSA-8854691 | Interleukin-20 family signaling | 2.545837e-01 | 0.594 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 1.916077e-01 | 0.718 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 1.997601e-01 | 0.699 |
| R-HSA-71240 | Tryptophan catabolism | 8.271405e-02 | 1.082 |
| R-HSA-391903 | Eicosanoid ligand-binding receptors | 2.237302e-01 | 0.650 |
| R-HSA-416482 | G alpha (12/13) signalling events | 5.761037e-02 | 1.239 |
| R-HSA-3000170 | Syndecan interactions | 2.545837e-01 | 0.594 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 8.958063e-02 | 1.048 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 1.343214e-01 | 0.872 |
| R-HSA-187687 | Signalling to ERKs | 6.820738e-02 | 1.166 |
| R-HSA-2672351 | Stimuli-sensing channels | 3.446473e-02 | 1.463 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 1.252887e-01 | 0.902 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 2.055575e-01 | 0.687 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 4.988667e-02 | 1.302 |
| R-HSA-9748787 | Azathioprine ADME | 1.174267e-01 | 0.930 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 2.545837e-01 | 0.594 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 1.515258e-01 | 0.820 |
| R-HSA-9679191 | Potential therapeutics for SARS | 2.425042e-01 | 0.615 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 1.317106e-01 | 0.880 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 1.317106e-01 | 0.880 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 4.551433e-02 | 1.342 |
| R-HSA-449147 | Signaling by Interleukins | 3.214241e-02 | 1.493 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 2.371482e-01 | 0.625 |
| R-HSA-9020558 | Interleukin-2 signaling | 1.321830e-01 | 0.879 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 2.158205e-01 | 0.666 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 2.952146e-02 | 1.530 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 1.410919e-01 | 0.850 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 1.208587e-01 | 0.918 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 9.806232e-02 | 1.008 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 2.159120e-01 | 0.666 |
| R-HSA-1500931 | Cell-Cell communication | 5.597182e-02 | 1.252 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 1.366144e-01 | 0.865 |
| R-HSA-9700206 | Signaling by ALK in cancer | 1.208587e-01 | 0.918 |
| R-HSA-9711123 | Cellular response to chemical stress | 7.382336e-02 | 1.132 |
| R-HSA-983712 | Ion channel transport | 1.612795e-01 | 0.792 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 1.749220e-01 | 0.757 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 1.774826e-01 | 0.751 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 3.484379e-02 | 1.458 |
| R-HSA-373760 | L1CAM interactions | 1.459187e-01 | 0.836 |
| R-HSA-446728 | Cell junction organization | 1.859454e-01 | 0.731 |
| R-HSA-5693538 | Homology Directed Repair | 1.506474e-01 | 0.822 |
| R-HSA-418990 | Adherens junctions interactions | 2.222551e-01 | 0.653 |
| R-HSA-451927 | Interleukin-2 family signaling | 8.271405e-02 | 1.082 |
| R-HSA-73887 | Death Receptor Signaling | 9.837836e-02 | 1.007 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 1.108678e-01 | 0.955 |
| R-HSA-977225 | Amyloid fiber formation | 6.250019e-02 | 1.204 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 1.499157e-01 | 0.824 |
| R-HSA-69306 | DNA Replication | 2.505753e-01 | 0.601 |
| R-HSA-9645723 | Diseases of programmed cell death | 7.643963e-02 | 1.117 |
| R-HSA-211000 | Gene Silencing by RNA | 1.208587e-01 | 0.918 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 2.500833e-01 | 0.602 |
| R-HSA-9830369 | Kidney development | 1.764132e-01 | 0.753 |
| R-HSA-1989781 | PPARA activates gene expression | 2.559786e-01 | 0.592 |
| R-HSA-3247509 | Chromatin modifying enzymes | 2.569725e-01 | 0.590 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 2.575493e-01 | 0.589 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 2.613983e-01 | 0.583 |
| R-HSA-9610379 | HCMV Late Events | 2.613983e-01 | 0.583 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 2.621047e-01 | 0.582 |
| R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse | 2.621047e-01 | 0.582 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 2.621047e-01 | 0.582 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 2.621047e-01 | 0.582 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 2.621047e-01 | 0.582 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 2.621047e-01 | 0.582 |
| R-HSA-429947 | Deadenylation of mRNA | 2.621047e-01 | 0.582 |
| R-HSA-6783589 | Interleukin-6 family signaling | 2.621047e-01 | 0.582 |
| R-HSA-202424 | Downstream TCR signaling | 2.650191e-01 | 0.577 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 2.687544e-01 | 0.571 |
| R-HSA-5654695 | PI-3K cascade:FGFR2 | 2.695503e-01 | 0.569 |
| R-HSA-9620244 | Long-term potentiation | 2.695503e-01 | 0.569 |
| R-HSA-5654693 | FRS-mediated FGFR1 signaling | 2.695503e-01 | 0.569 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 2.695503e-01 | 0.569 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 2.695503e-01 | 0.569 |
| R-HSA-2160916 | Hyaluronan degradation | 2.695503e-01 | 0.569 |
| R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 2.695503e-01 | 0.569 |
| R-HSA-157118 | Signaling by NOTCH | 2.702721e-01 | 0.568 |
| R-HSA-381070 | IRE1alpha activates chaperones | 2.724895e-01 | 0.565 |
| R-HSA-391251 | Protein folding | 2.762240e-01 | 0.559 |
| R-HSA-5689901 | Metalloprotease DUBs | 2.769212e-01 | 0.558 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 2.769212e-01 | 0.558 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 2.769212e-01 | 0.558 |
| R-HSA-171306 | Packaging Of Telomere Ends | 2.842182e-01 | 0.546 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 2.842182e-01 | 0.546 |
| R-HSA-8949613 | Cristae formation | 2.842182e-01 | 0.546 |
| R-HSA-193807 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol | 2.842182e-01 | 0.546 |
| R-HSA-4839726 | Chromatin organization | 2.904410e-01 | 0.537 |
| R-HSA-5654700 | FRS-mediated FGFR2 signaling | 2.914420e-01 | 0.535 |
| R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 2.914420e-01 | 0.535 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 2.914420e-01 | 0.535 |
| R-HSA-9609646 | HCMV Infection | 2.926957e-01 | 0.534 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 2.948750e-01 | 0.530 |
| R-HSA-421270 | Cell-cell junction organization | 2.949528e-01 | 0.530 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 2.985933e-01 | 0.525 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 2.985933e-01 | 0.525 |
| R-HSA-420092 | Glucagon-type ligand receptors | 2.985933e-01 | 0.525 |
| R-HSA-9615710 | Late endosomal microautophagy | 2.985933e-01 | 0.525 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 2.985933e-01 | 0.525 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 2.985933e-01 | 0.525 |
| R-HSA-180024 | DARPP-32 events | 2.985933e-01 | 0.525 |
| R-HSA-9006335 | Signaling by Erythropoietin | 2.985933e-01 | 0.525 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 2.985933e-01 | 0.525 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 2.985933e-01 | 0.525 |
| R-HSA-157579 | Telomere Maintenance | 2.985985e-01 | 0.525 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 2.985985e-01 | 0.525 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 2.985985e-01 | 0.525 |
| R-HSA-422356 | Regulation of insulin secretion | 3.023190e-01 | 0.520 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 3.023190e-01 | 0.520 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 3.023190e-01 | 0.520 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 3.023190e-01 | 0.520 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 3.056729e-01 | 0.515 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 3.056729e-01 | 0.515 |
| R-HSA-2424491 | DAP12 signaling | 3.056729e-01 | 0.515 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 3.056729e-01 | 0.515 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 3.056729e-01 | 0.515 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 3.056729e-01 | 0.515 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 3.126815e-01 | 0.505 |
| R-HSA-399719 | Trafficking of AMPA receptors | 3.126815e-01 | 0.505 |
| R-HSA-186763 | Downstream signal transduction | 3.126815e-01 | 0.505 |
| R-HSA-1483255 | PI Metabolism | 3.171648e-01 | 0.499 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 3.196197e-01 | 0.495 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 3.196197e-01 | 0.495 |
| R-HSA-9734767 | Developmental Cell Lineages | 3.221939e-01 | 0.492 |
| R-HSA-111885 | Opioid Signalling | 3.245617e-01 | 0.489 |
| R-HSA-354192 | Integrin signaling | 3.264883e-01 | 0.486 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 3.264883e-01 | 0.486 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 3.264883e-01 | 0.486 |
| R-HSA-397795 | G-protein beta:gamma signalling | 3.264883e-01 | 0.486 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 3.264883e-01 | 0.486 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 3.264883e-01 | 0.486 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 3.319384e-01 | 0.479 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 3.332881e-01 | 0.477 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 3.332881e-01 | 0.477 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 3.332881e-01 | 0.477 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 3.356185e-01 | 0.474 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 3.400196e-01 | 0.468 |
| R-HSA-5673000 | RAF activation | 3.400196e-01 | 0.468 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 3.400196e-01 | 0.468 |
| R-HSA-1980145 | Signaling by NOTCH2 | 3.400196e-01 | 0.468 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 3.400196e-01 | 0.468 |
| R-HSA-2142845 | Hyaluronan metabolism | 3.400196e-01 | 0.468 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 3.400196e-01 | 0.468 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 3.400196e-01 | 0.468 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 3.429607e-01 | 0.465 |
| R-HSA-69275 | G2/M Transition | 3.437628e-01 | 0.464 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 3.466224e-01 | 0.460 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 3.466835e-01 | 0.460 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 3.466835e-01 | 0.460 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 3.466835e-01 | 0.460 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 3.466835e-01 | 0.460 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 3.468196e-01 | 0.460 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 3.492694e-01 | 0.457 |
| R-HSA-202403 | TCR signaling | 3.502774e-01 | 0.456 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 3.502774e-01 | 0.456 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 3.532805e-01 | 0.452 |
| R-HSA-9682385 | FLT3 signaling in disease | 3.532805e-01 | 0.452 |
| R-HSA-3371511 | HSF1 activation | 3.532805e-01 | 0.452 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 3.532805e-01 | 0.452 |
| R-HSA-6798695 | Neutrophil degranulation | 3.552796e-01 | 0.449 |
| R-HSA-168898 | Toll-like Receptor Cascades | 3.575205e-01 | 0.447 |
| R-HSA-110331 | Cleavage of the damaged purine | 3.598114e-01 | 0.444 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 3.612005e-01 | 0.442 |
| R-HSA-68877 | Mitotic Prometaphase | 3.630141e-01 | 0.440 |
| R-HSA-9658195 | Leishmania infection | 3.633501e-01 | 0.440 |
| R-HSA-9824443 | Parasitic Infection Pathways | 3.633501e-01 | 0.440 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 3.657583e-01 | 0.437 |
| R-HSA-9679506 | SARS-CoV Infections | 3.659707e-01 | 0.437 |
| R-HSA-73927 | Depurination | 3.662767e-01 | 0.436 |
| R-HSA-9609690 | HCMV Early Events | 3.712410e-01 | 0.430 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 3.720559e-01 | 0.429 |
| R-HSA-71336 | Pentose phosphate pathway | 3.726771e-01 | 0.429 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 3.726771e-01 | 0.429 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 3.726771e-01 | 0.429 |
| R-HSA-909733 | Interferon alpha/beta signaling | 3.756582e-01 | 0.425 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 3.756582e-01 | 0.425 |
| R-HSA-202433 | Generation of second messenger molecules | 3.790132e-01 | 0.421 |
| R-HSA-5260271 | Diseases of Immune System | 3.790132e-01 | 0.421 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 3.790132e-01 | 0.421 |
| R-HSA-975576 | N-glycan antennae elongation in the medial/trans-Golgi | 3.790132e-01 | 0.421 |
| R-HSA-8982491 | Glycogen metabolism | 3.790132e-01 | 0.421 |
| R-HSA-9824446 | Viral Infection Pathways | 3.790349e-01 | 0.421 |
| R-HSA-2980736 | Peptide hormone metabolism | 3.828377e-01 | 0.417 |
| R-HSA-1592230 | Mitochondrial biogenesis | 3.828377e-01 | 0.417 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 3.852858e-01 | 0.414 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 3.852858e-01 | 0.414 |
| R-HSA-9694548 | Maturation of spike protein | 3.852858e-01 | 0.414 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 3.852858e-01 | 0.414 |
| R-HSA-913531 | Interferon Signaling | 3.888407e-01 | 0.410 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 3.899821e-01 | 0.409 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 3.899821e-01 | 0.409 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 3.914953e-01 | 0.407 |
| R-HSA-6811438 | Intra-Golgi traffic | 3.914953e-01 | 0.407 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 3.914953e-01 | 0.407 |
| R-HSA-72172 | mRNA Splicing | 3.957958e-01 | 0.403 |
| R-HSA-3371556 | Cellular response to heat stress | 3.970899e-01 | 0.401 |
| R-HSA-73886 | Chromosome Maintenance | 3.970899e-01 | 0.401 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 3.976426e-01 | 0.401 |
| R-HSA-73928 | Depyrimidination | 3.976426e-01 | 0.401 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 3.976426e-01 | 0.401 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 4.006297e-01 | 0.397 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 4.006297e-01 | 0.397 |
| R-HSA-195721 | Signaling by WNT | 4.021668e-01 | 0.396 |
| R-HSA-5654743 | Signaling by FGFR4 | 4.037281e-01 | 0.394 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 4.037281e-01 | 0.394 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 4.037281e-01 | 0.394 |
| R-HSA-6809371 | Formation of the cornified envelope | 4.076802e-01 | 0.390 |
| R-HSA-2172127 | DAP12 interactions | 4.097524e-01 | 0.387 |
| R-HSA-388396 | GPCR downstream signalling | 4.141884e-01 | 0.383 |
| R-HSA-194138 | Signaling by VEGF | 4.146908e-01 | 0.382 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 4.157163e-01 | 0.381 |
| R-HSA-5654741 | Signaling by FGFR3 | 4.157163e-01 | 0.381 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 4.157163e-01 | 0.381 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 4.157163e-01 | 0.381 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 4.157163e-01 | 0.381 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 4.157163e-01 | 0.381 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 4.157163e-01 | 0.381 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 4.200988e-01 | 0.377 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 4.216203e-01 | 0.375 |
| R-HSA-75153 | Apoptotic execution phase | 4.216203e-01 | 0.375 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 4.274650e-01 | 0.369 |
| R-HSA-9634597 | GPER1 signaling | 4.332510e-01 | 0.363 |
| R-HSA-70263 | Gluconeogenesis | 4.332510e-01 | 0.363 |
| R-HSA-9748784 | Drug ADME | 4.334644e-01 | 0.363 |
| R-HSA-9843745 | Adipogenesis | 4.388963e-01 | 0.358 |
| R-HSA-109704 | PI3K Cascade | 4.446493e-01 | 0.352 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 4.502627e-01 | 0.347 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 4.517360e-01 | 0.345 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 4.558196e-01 | 0.341 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 4.558196e-01 | 0.341 |
| R-HSA-162906 | HIV Infection | 4.572334e-01 | 0.340 |
| R-HSA-112315 | Transmission across Chemical Synapses | 4.584039e-01 | 0.339 |
| R-HSA-1221632 | Meiotic synapsis | 4.613208e-01 | 0.336 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 4.650654e-01 | 0.332 |
| R-HSA-9948299 | Ribosome-associated quality control | 4.658838e-01 | 0.332 |
| R-HSA-5358351 | Signaling by Hedgehog | 4.658838e-01 | 0.332 |
| R-HSA-72649 | Translation initiation complex formation | 4.667667e-01 | 0.331 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 4.667667e-01 | 0.331 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 4.667667e-01 | 0.331 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 4.692038e-01 | 0.329 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 4.721578e-01 | 0.326 |
| R-HSA-9753281 | Paracetamol ADME | 4.721578e-01 | 0.326 |
| R-HSA-9012852 | Signaling by NOTCH3 | 4.721578e-01 | 0.326 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 4.774948e-01 | 0.321 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 4.774948e-01 | 0.321 |
| R-HSA-5654736 | Signaling by FGFR1 | 4.774948e-01 | 0.321 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 4.774948e-01 | 0.321 |
| R-HSA-177929 | Signaling by EGFR | 4.774948e-01 | 0.321 |
| R-HSA-15869 | Metabolism of nucleotides | 4.805802e-01 | 0.318 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 4.823607e-01 | 0.317 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 4.827782e-01 | 0.316 |
| R-HSA-9764561 | Regulation of CDH1 Function | 4.827782e-01 | 0.316 |
| R-HSA-112399 | IRS-mediated signalling | 4.827782e-01 | 0.316 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 4.880084e-01 | 0.312 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 4.931861e-01 | 0.307 |
| R-HSA-1227986 | Signaling by ERBB2 | 4.983118e-01 | 0.302 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 4.983118e-01 | 0.302 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 4.983118e-01 | 0.302 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 4.983118e-01 | 0.302 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 4.983118e-01 | 0.302 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 4.983118e-01 | 0.302 |
| R-HSA-379724 | tRNA Aminoacylation | 4.983118e-01 | 0.302 |
| R-HSA-168249 | Innate Immune System | 5.028301e-01 | 0.299 |
| R-HSA-211976 | Endogenous sterols | 5.033859e-01 | 0.298 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 5.033859e-01 | 0.298 |
| R-HSA-445717 | Aquaporin-mediated transport | 5.033859e-01 | 0.298 |
| R-HSA-450294 | MAP kinase activation | 5.033859e-01 | 0.298 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 5.080668e-01 | 0.294 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 5.084090e-01 | 0.294 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 5.084090e-01 | 0.294 |
| R-HSA-1268020 | Mitochondrial protein import | 5.084090e-01 | 0.294 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 5.084090e-01 | 0.294 |
| R-HSA-9707616 | Heme signaling | 5.084090e-01 | 0.294 |
| R-HSA-186797 | Signaling by PDGF | 5.084090e-01 | 0.294 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 5.133816e-01 | 0.290 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 5.133816e-01 | 0.290 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 5.133816e-01 | 0.290 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 5.133816e-01 | 0.290 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 5.133816e-01 | 0.290 |
| R-HSA-2428924 | IGF1R signaling cascade | 5.183042e-01 | 0.285 |
| R-HSA-74751 | Insulin receptor signalling cascade | 5.183042e-01 | 0.285 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 5.231773e-01 | 0.281 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 5.280015e-01 | 0.277 |
| R-HSA-162587 | HIV Life Cycle | 5.298723e-01 | 0.276 |
| R-HSA-372790 | Signaling by GPCR | 5.327499e-01 | 0.273 |
| R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 5.327771e-01 | 0.273 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 5.375046e-01 | 0.270 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 5.375046e-01 | 0.270 |
| R-HSA-73894 | DNA Repair | 5.380279e-01 | 0.269 |
| R-HSA-9006936 | Signaling by TGFB family members | 5.390163e-01 | 0.268 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 5.468177e-01 | 0.262 |
| R-HSA-204005 | COPII-mediated vesicle transport | 5.468177e-01 | 0.262 |
| R-HSA-448424 | Interleukin-17 signaling | 5.468177e-01 | 0.262 |
| R-HSA-416476 | G alpha (q) signalling events | 5.499859e-01 | 0.260 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 5.514040e-01 | 0.259 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 5.514040e-01 | 0.259 |
| R-HSA-5632684 | Hedgehog 'on' state | 5.514040e-01 | 0.259 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 5.514040e-01 | 0.259 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 5.514040e-01 | 0.259 |
| R-HSA-168256 | Immune System | 5.546508e-01 | 0.256 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 5.559443e-01 | 0.255 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 5.559443e-01 | 0.255 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 5.559443e-01 | 0.255 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 5.604388e-01 | 0.251 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 5.604388e-01 | 0.251 |
| R-HSA-9749641 | Aspirin ADME | 5.604388e-01 | 0.251 |
| R-HSA-382551 | Transport of small molecules | 5.643230e-01 | 0.248 |
| R-HSA-9013694 | Signaling by NOTCH4 | 5.648882e-01 | 0.248 |
| R-HSA-1236394 | Signaling by ERBB4 | 5.648882e-01 | 0.248 |
| R-HSA-380287 | Centrosome maturation | 5.692928e-01 | 0.245 |
| R-HSA-8852135 | Protein ubiquitination | 5.692928e-01 | 0.245 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 5.692928e-01 | 0.245 |
| R-HSA-5663205 | Infectious disease | 5.707642e-01 | 0.244 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 5.714908e-01 | 0.243 |
| R-HSA-1980143 | Signaling by NOTCH1 | 5.736530e-01 | 0.241 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 5.743601e-01 | 0.241 |
| R-HSA-9694635 | Translation of Structural Proteins | 5.779694e-01 | 0.238 |
| R-HSA-216083 | Integrin cell surface interactions | 5.822424e-01 | 0.235 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 5.848755e-01 | 0.233 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 5.856984e-01 | 0.232 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 5.864723e-01 | 0.232 |
| R-HSA-5654738 | Signaling by FGFR2 | 5.906597e-01 | 0.229 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 5.906597e-01 | 0.229 |
| R-HSA-6806834 | Signaling by MET | 5.906597e-01 | 0.229 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 5.948050e-01 | 0.226 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 6.029707e-01 | 0.220 |
| R-HSA-1643685 | Disease | 6.042237e-01 | 0.219 |
| R-HSA-1483257 | Phospholipid metabolism | 6.201603e-01 | 0.207 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 6.210075e-01 | 0.207 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 6.226766e-01 | 0.206 |
| R-HSA-5617833 | Cilium Assembly | 6.262307e-01 | 0.203 |
| R-HSA-156902 | Peptide chain elongation | 6.264995e-01 | 0.203 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 6.306789e-01 | 0.200 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 6.340302e-01 | 0.198 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 6.340302e-01 | 0.198 |
| R-HSA-73884 | Base Excision Repair | 6.340302e-01 | 0.198 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 6.414100e-01 | 0.193 |
| R-HSA-1280218 | Adaptive Immune System | 6.444313e-01 | 0.191 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 6.450443e-01 | 0.190 |
| R-HSA-74752 | Signaling by Insulin receptor | 6.450443e-01 | 0.190 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 6.450443e-01 | 0.190 |
| R-HSA-428157 | Sphingolipid metabolism | 6.539689e-01 | 0.184 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 6.557289e-01 | 0.183 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 6.557289e-01 | 0.183 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 6.564080e-01 | 0.183 |
| R-HSA-376176 | Signaling by ROBO receptors | 6.588335e-01 | 0.181 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 6.592189e-01 | 0.181 |
| R-HSA-72764 | Eukaryotic Translation Termination | 6.592189e-01 | 0.181 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 6.626737e-01 | 0.179 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 6.626737e-01 | 0.179 |
| R-HSA-1296071 | Potassium Channels | 6.626737e-01 | 0.179 |
| R-HSA-6805567 | Keratinization | 6.683996e-01 | 0.175 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 6.694793e-01 | 0.174 |
| R-HSA-190236 | Signaling by FGFR | 6.694793e-01 | 0.174 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 6.728307e-01 | 0.172 |
| R-HSA-199991 | Membrane Trafficking | 6.743290e-01 | 0.171 |
| R-HSA-70171 | Glycolysis | 6.761484e-01 | 0.170 |
| R-HSA-382556 | ABC-family proteins mediated transport | 6.761484e-01 | 0.170 |
| R-HSA-5610787 | Hedgehog 'off' state | 6.761484e-01 | 0.170 |
| R-HSA-2408557 | Selenocysteine synthesis | 6.794326e-01 | 0.168 |
| R-HSA-9020702 | Interleukin-1 signaling | 6.794326e-01 | 0.168 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 6.826837e-01 | 0.166 |
| R-HSA-192823 | Viral mRNA Translation | 6.859021e-01 | 0.164 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 6.890880e-01 | 0.162 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 6.890880e-01 | 0.162 |
| R-HSA-1474244 | Extracellular matrix organization | 6.919258e-01 | 0.160 |
| R-HSA-418346 | Platelet homeostasis | 6.984543e-01 | 0.156 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 7.015136e-01 | 0.154 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 7.045421e-01 | 0.152 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 7.045421e-01 | 0.152 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 7.126346e-01 | 0.147 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 7.163538e-01 | 0.145 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 7.163538e-01 | 0.145 |
| R-HSA-1483249 | Inositol phosphate metabolism | 7.163538e-01 | 0.145 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 7.172055e-01 | 0.144 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 7.238117e-01 | 0.140 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 7.249034e-01 | 0.140 |
| R-HSA-72312 | rRNA processing | 7.254061e-01 | 0.139 |
| R-HSA-212436 | Generic Transcription Pathway | 7.315977e-01 | 0.136 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 7.331969e-01 | 0.135 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 7.331969e-01 | 0.135 |
| R-HSA-70326 | Glucose metabolism | 7.359058e-01 | 0.133 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 7.412418e-01 | 0.130 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 7.464707e-01 | 0.127 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 7.464707e-01 | 0.127 |
| R-HSA-392499 | Metabolism of proteins | 7.465534e-01 | 0.127 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 7.483860e-01 | 0.126 |
| R-HSA-162909 | Host Interactions of HIV factors | 7.541177e-01 | 0.123 |
| R-HSA-69206 | G1/S Transition | 7.590880e-01 | 0.120 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 7.615355e-01 | 0.118 |
| R-HSA-5688426 | Deubiquitination | 7.687596e-01 | 0.114 |
| R-HSA-9909396 | Circadian clock | 7.779900e-01 | 0.109 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 7.779900e-01 | 0.109 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 7.974979e-01 | 0.098 |
| R-HSA-9664407 | Parasite infection | 7.974979e-01 | 0.098 |
| R-HSA-9664417 | Leishmania phagocytosis | 7.974979e-01 | 0.098 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 7.995574e-01 | 0.097 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 8.036141e-01 | 0.095 |
| R-HSA-74160 | Gene expression (Transcription) | 8.051474e-01 | 0.094 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 8.056118e-01 | 0.094 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 8.075893e-01 | 0.093 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 8.114844e-01 | 0.091 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 8.134025e-01 | 0.090 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 8.227059e-01 | 0.085 |
| R-HSA-9609507 | Protein localization | 8.245104e-01 | 0.084 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 8.262968e-01 | 0.083 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 8.280650e-01 | 0.082 |
| R-HSA-9612973 | Autophagy | 8.298154e-01 | 0.081 |
| R-HSA-9711097 | Cellular response to starvation | 8.332632e-01 | 0.079 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 8.332632e-01 | 0.079 |
| R-HSA-72766 | Translation | 8.364488e-01 | 0.078 |
| R-HSA-73857 | RNA Polymerase II Transcription | 8.364982e-01 | 0.078 |
| R-HSA-5633007 | Regulation of TP53 Activity | 8.366415e-01 | 0.077 |
| R-HSA-109581 | Apoptosis | 8.399519e-01 | 0.076 |
| R-HSA-2408522 | Selenoamino acid metabolism | 8.431955e-01 | 0.074 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 8.479388e-01 | 0.072 |
| R-HSA-5619102 | SLC transporter disorders | 8.479388e-01 | 0.072 |
| R-HSA-5653656 | Vesicle-mediated transport | 8.490384e-01 | 0.071 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 8.584593e-01 | 0.066 |
| R-HSA-5689880 | Ub-specific processing proteases | 8.584593e-01 | 0.066 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 8.584593e-01 | 0.066 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 8.599020e-01 | 0.066 |
| R-HSA-8957322 | Metabolism of steroids | 8.650581e-01 | 0.063 |
| R-HSA-611105 | Respiratory electron transport | 8.655279e-01 | 0.063 |
| R-HSA-168255 | Influenza Infection | 8.668989e-01 | 0.062 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 8.723203e-01 | 0.059 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 8.823615e-01 | 0.054 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 8.846964e-01 | 0.053 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 8.926869e-01 | 0.049 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 8.959405e-01 | 0.048 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 8.959405e-01 | 0.048 |
| R-HSA-5357801 | Programmed Cell Death | 8.990961e-01 | 0.046 |
| R-HSA-68882 | Mitotic Anaphase | 9.098743e-01 | 0.041 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 9.107954e-01 | 0.041 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.265439e-01 | 0.033 |
| R-HSA-418594 | G alpha (i) signalling events | 9.324739e-01 | 0.030 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 9.344748e-01 | 0.029 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.405307e-01 | 0.027 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 9.523902e-01 | 0.021 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 9.543145e-01 | 0.020 |
| R-HSA-556833 | Metabolism of lipids | 9.732811e-01 | 0.012 |
| R-HSA-1430728 | Metabolism | 9.781749e-01 | 0.010 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 9.841026e-01 | 0.007 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.852172e-01 | 0.006 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.858189e-01 | 0.006 |
| R-HSA-500792 | GPCR ligand binding | 9.863053e-01 | 0.006 |
| R-HSA-597592 | Post-translational protein modification | 9.906158e-01 | 0.004 |
| R-HSA-211859 | Biological oxidations | 9.963085e-01 | 0.002 |
| R-HSA-9709957 | Sensory Perception | 9.999742e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
MTOR |
0.850 | 0.244 | 1 | 0.798 |
MST4 |
0.850 | 0.250 | 2 | 0.830 |
COT |
0.849 | 0.082 | 2 | 0.777 |
CDKL5 |
0.843 | 0.147 | -3 | 0.756 |
CDC7 |
0.843 | 0.052 | 1 | 0.741 |
NLK |
0.842 | 0.098 | 1 | 0.790 |
ERK5 |
0.841 | 0.165 | 1 | 0.846 |
NUAK2 |
0.841 | 0.117 | -3 | 0.791 |
ULK2 |
0.841 | 0.036 | 2 | 0.742 |
PIM3 |
0.840 | 0.071 | -3 | 0.788 |
NIM1 |
0.840 | 0.245 | 3 | 0.752 |
CLK3 |
0.840 | 0.124 | 1 | 0.745 |
WNK1 |
0.839 | 0.100 | -2 | 0.857 |
PRKD1 |
0.839 | 0.106 | -3 | 0.817 |
CDKL1 |
0.839 | 0.106 | -3 | 0.756 |
MARK4 |
0.838 | 0.182 | 4 | 0.842 |
NDR2 |
0.838 | 0.083 | -3 | 0.794 |
TBK1 |
0.838 | 0.013 | 1 | 0.756 |
RSK2 |
0.838 | 0.095 | -3 | 0.727 |
PRPK |
0.838 | -0.001 | -1 | 0.753 |
SRPK1 |
0.838 | 0.099 | -3 | 0.719 |
AMPKA1 |
0.838 | 0.128 | -3 | 0.810 |
PKN2 |
0.837 | 0.117 | -3 | 0.788 |
PKCD |
0.836 | 0.156 | 2 | 0.761 |
NDR1 |
0.836 | 0.082 | -3 | 0.784 |
RSK3 |
0.836 | 0.098 | -3 | 0.721 |
GCN2 |
0.836 | -0.056 | 2 | 0.753 |
RAF1 |
0.835 | 0.003 | 1 | 0.805 |
PKN3 |
0.835 | 0.075 | -3 | 0.789 |
HIPK4 |
0.835 | 0.094 | 1 | 0.734 |
TGFBR2 |
0.834 | 0.063 | -2 | 0.855 |
PDHK4 |
0.834 | -0.066 | 1 | 0.820 |
CAMK1B |
0.833 | 0.020 | -3 | 0.801 |
P90RSK |
0.833 | 0.072 | -3 | 0.741 |
AMPKA2 |
0.833 | 0.113 | -3 | 0.777 |
MOS |
0.833 | 0.009 | 1 | 0.783 |
IKKE |
0.833 | -0.022 | 1 | 0.751 |
PRKD2 |
0.832 | 0.066 | -3 | 0.757 |
NEK6 |
0.832 | 0.028 | -2 | 0.878 |
PDHK1 |
0.832 | -0.041 | 1 | 0.814 |
KIS |
0.832 | 0.091 | 1 | 0.673 |
NIK |
0.832 | 0.083 | -3 | 0.821 |
DSTYK |
0.831 | -0.017 | 2 | 0.801 |
LATS2 |
0.830 | 0.039 | -5 | 0.803 |
PIM1 |
0.830 | 0.085 | -3 | 0.739 |
PKACG |
0.830 | 0.074 | -2 | 0.730 |
CHAK2 |
0.830 | 0.069 | -1 | 0.715 |
PKCA |
0.830 | 0.176 | 2 | 0.722 |
SRPK2 |
0.830 | 0.083 | -3 | 0.639 |
TSSK1 |
0.830 | 0.091 | -3 | 0.829 |
ICK |
0.830 | 0.080 | -3 | 0.803 |
BMPR2 |
0.829 | -0.068 | -2 | 0.904 |
BCKDK |
0.829 | 0.003 | -1 | 0.727 |
SKMLCK |
0.829 | 0.041 | -2 | 0.844 |
NEK7 |
0.828 | -0.050 | -3 | 0.798 |
PHKG1 |
0.828 | 0.073 | -3 | 0.787 |
AURC |
0.828 | 0.086 | -2 | 0.646 |
IKKB |
0.828 | -0.117 | -2 | 0.765 |
CDK18 |
0.828 | 0.138 | 1 | 0.579 |
PKCG |
0.828 | 0.133 | 2 | 0.726 |
RIPK3 |
0.828 | -0.058 | 3 | 0.713 |
PKCB |
0.828 | 0.133 | 2 | 0.720 |
NEK9 |
0.828 | 0.032 | 2 | 0.799 |
IRE1 |
0.828 | 0.037 | 1 | 0.742 |
CAMK2D |
0.827 | 0.032 | -3 | 0.808 |
QSK |
0.827 | 0.153 | 4 | 0.830 |
MAPKAPK3 |
0.827 | 0.013 | -3 | 0.757 |
CAMLCK |
0.826 | 0.028 | -2 | 0.853 |
ULK1 |
0.826 | -0.078 | -3 | 0.800 |
CAMK2G |
0.826 | -0.076 | 2 | 0.746 |
WNK3 |
0.826 | -0.094 | 1 | 0.776 |
QIK |
0.826 | 0.116 | -3 | 0.783 |
SGK3 |
0.826 | 0.147 | -3 | 0.720 |
ATR |
0.825 | -0.043 | 1 | 0.721 |
MELK |
0.825 | 0.041 | -3 | 0.764 |
MNK2 |
0.825 | 0.069 | -2 | 0.779 |
SIK |
0.825 | 0.130 | -3 | 0.718 |
P70S6KB |
0.825 | 0.043 | -3 | 0.743 |
CDK7 |
0.825 | 0.063 | 1 | 0.639 |
HUNK |
0.825 | -0.048 | 2 | 0.708 |
DAPK2 |
0.824 | 0.025 | -3 | 0.813 |
CDK5 |
0.824 | 0.125 | 1 | 0.644 |
CDK8 |
0.824 | 0.053 | 1 | 0.629 |
PAK3 |
0.824 | 0.029 | -2 | 0.791 |
TSSK2 |
0.823 | 0.026 | -5 | 0.853 |
MLK1 |
0.823 | -0.052 | 2 | 0.771 |
SRPK3 |
0.823 | 0.070 | -3 | 0.679 |
NUAK1 |
0.823 | 0.035 | -3 | 0.738 |
NEK2 |
0.823 | 0.084 | 2 | 0.804 |
CDK19 |
0.822 | 0.067 | 1 | 0.596 |
CLK1 |
0.822 | 0.090 | -3 | 0.701 |
MASTL |
0.820 | -0.085 | -2 | 0.827 |
PKCZ |
0.820 | 0.079 | 2 | 0.763 |
PKCH |
0.820 | 0.087 | 2 | 0.709 |
HIPK1 |
0.820 | 0.116 | 1 | 0.696 |
CLK4 |
0.820 | 0.070 | -3 | 0.719 |
PLK4 |
0.820 | 0.097 | 2 | 0.580 |
PRKD3 |
0.820 | 0.033 | -3 | 0.713 |
LATS1 |
0.819 | 0.091 | -3 | 0.799 |
MLK2 |
0.819 | -0.017 | 2 | 0.764 |
PAK1 |
0.819 | 0.024 | -2 | 0.784 |
IRE2 |
0.819 | 0.016 | 2 | 0.742 |
PKG2 |
0.819 | 0.062 | -2 | 0.661 |
ANKRD3 |
0.819 | -0.058 | 1 | 0.809 |
MNK1 |
0.818 | 0.054 | -2 | 0.790 |
DYRK2 |
0.818 | 0.064 | 1 | 0.680 |
PAK6 |
0.818 | 0.041 | -2 | 0.718 |
MAPKAPK2 |
0.818 | 0.008 | -3 | 0.708 |
CDK13 |
0.818 | 0.058 | 1 | 0.623 |
P38A |
0.818 | 0.098 | 1 | 0.712 |
PIM2 |
0.818 | 0.099 | -3 | 0.701 |
RIPK1 |
0.818 | -0.101 | 1 | 0.775 |
PKACB |
0.818 | 0.091 | -2 | 0.665 |
DCAMKL1 |
0.817 | 0.099 | -3 | 0.750 |
MARK3 |
0.817 | 0.111 | 4 | 0.788 |
MST3 |
0.817 | 0.212 | 2 | 0.808 |
AKT2 |
0.817 | 0.078 | -3 | 0.650 |
HIPK3 |
0.816 | 0.096 | 1 | 0.724 |
CDK17 |
0.816 | 0.092 | 1 | 0.526 |
PKCT |
0.816 | 0.115 | 2 | 0.713 |
RSK4 |
0.816 | 0.065 | -3 | 0.698 |
JNK2 |
0.816 | 0.087 | 1 | 0.605 |
CDK14 |
0.816 | 0.121 | 1 | 0.619 |
PKR |
0.816 | 0.056 | 1 | 0.775 |
TTBK2 |
0.815 | -0.107 | 2 | 0.678 |
HIPK2 |
0.815 | 0.089 | 1 | 0.600 |
MARK2 |
0.815 | 0.100 | 4 | 0.760 |
CDK9 |
0.815 | 0.056 | 1 | 0.639 |
BRSK2 |
0.815 | 0.002 | -3 | 0.777 |
MSK2 |
0.815 | 0.001 | -3 | 0.714 |
PKCI |
0.814 | 0.117 | 2 | 0.751 |
MLK3 |
0.814 | -0.013 | 2 | 0.724 |
AURB |
0.814 | 0.040 | -2 | 0.647 |
CAMK4 |
0.814 | -0.067 | -3 | 0.766 |
CDK12 |
0.814 | 0.068 | 1 | 0.604 |
YSK4 |
0.814 | 0.004 | 1 | 0.775 |
GRK5 |
0.813 | -0.188 | -3 | 0.778 |
PHKG2 |
0.813 | 0.058 | -3 | 0.744 |
P38B |
0.813 | 0.085 | 1 | 0.652 |
FAM20C |
0.812 | 0.008 | 2 | 0.510 |
BRSK1 |
0.812 | 0.004 | -3 | 0.751 |
CDK16 |
0.812 | 0.125 | 1 | 0.539 |
WNK4 |
0.811 | 0.033 | -2 | 0.856 |
CDK10 |
0.811 | 0.110 | 1 | 0.603 |
MPSK1 |
0.811 | 0.176 | 1 | 0.735 |
IKKA |
0.811 | -0.096 | -2 | 0.747 |
BMPR1B |
0.811 | 0.047 | 1 | 0.698 |
ALK4 |
0.811 | -0.010 | -2 | 0.871 |
CLK2 |
0.811 | 0.108 | -3 | 0.705 |
JNK3 |
0.811 | 0.056 | 1 | 0.636 |
ERK1 |
0.811 | 0.056 | 1 | 0.644 |
VRK2 |
0.811 | -0.028 | 1 | 0.813 |
DNAPK |
0.811 | 0.045 | 1 | 0.646 |
PAK2 |
0.811 | -0.019 | -2 | 0.774 |
MARK1 |
0.810 | 0.073 | 4 | 0.804 |
CDK3 |
0.810 | 0.092 | 1 | 0.542 |
CDK1 |
0.810 | 0.053 | 1 | 0.593 |
AKT1 |
0.810 | 0.087 | -3 | 0.671 |
CHAK1 |
0.810 | -0.062 | 2 | 0.770 |
PLK1 |
0.810 | -0.056 | -2 | 0.850 |
GRK1 |
0.809 | -0.056 | -2 | 0.808 |
PKCE |
0.809 | 0.122 | 2 | 0.723 |
DLK |
0.809 | -0.198 | 1 | 0.777 |
SSTK |
0.809 | 0.050 | 4 | 0.826 |
IRAK4 |
0.809 | 0.006 | 1 | 0.759 |
DYRK1A |
0.809 | 0.046 | 1 | 0.710 |
MEK1 |
0.809 | -0.061 | 2 | 0.762 |
MYLK4 |
0.808 | -0.012 | -2 | 0.771 |
TGFBR1 |
0.808 | 0.014 | -2 | 0.845 |
CAMK2A |
0.808 | -0.023 | 2 | 0.719 |
P38G |
0.808 | 0.066 | 1 | 0.532 |
CAMK2B |
0.808 | -0.022 | 2 | 0.682 |
ERK7 |
0.808 | 0.132 | 2 | 0.600 |
SNRK |
0.808 | -0.097 | 2 | 0.648 |
MSK1 |
0.807 | 0.013 | -3 | 0.712 |
CDK2 |
0.807 | 0.033 | 1 | 0.659 |
PRP4 |
0.807 | 0.105 | -3 | 0.814 |
CHK1 |
0.806 | -0.023 | -3 | 0.771 |
PRKX |
0.806 | 0.071 | -3 | 0.635 |
PKN1 |
0.806 | 0.078 | -3 | 0.687 |
PKACA |
0.805 | 0.067 | -2 | 0.613 |
TAO3 |
0.805 | 0.132 | 1 | 0.781 |
DCAMKL2 |
0.805 | 0.023 | -3 | 0.763 |
HRI |
0.805 | -0.056 | -2 | 0.891 |
ERK2 |
0.805 | 0.010 | 1 | 0.673 |
CAMK1G |
0.805 | -0.018 | -3 | 0.717 |
GRK6 |
0.804 | -0.171 | 1 | 0.744 |
P70S6K |
0.804 | 0.022 | -3 | 0.661 |
PERK |
0.804 | -0.040 | -2 | 0.883 |
MLK4 |
0.804 | -0.067 | 2 | 0.686 |
NEK5 |
0.804 | 0.025 | 1 | 0.782 |
AKT3 |
0.803 | 0.092 | -3 | 0.605 |
DYRK3 |
0.803 | 0.065 | 1 | 0.702 |
MAK |
0.803 | 0.138 | -2 | 0.684 |
SMG1 |
0.803 | -0.096 | 1 | 0.674 |
MEKK1 |
0.803 | -0.003 | 1 | 0.768 |
GRK7 |
0.803 | 0.012 | 1 | 0.702 |
ZAK |
0.803 | -0.010 | 1 | 0.756 |
HGK |
0.802 | 0.180 | 3 | 0.820 |
MEKK2 |
0.802 | 0.034 | 2 | 0.750 |
AURA |
0.802 | 0.011 | -2 | 0.621 |
GRK4 |
0.802 | -0.188 | -2 | 0.843 |
ATM |
0.801 | -0.108 | 1 | 0.645 |
MAPKAPK5 |
0.801 | -0.091 | -3 | 0.694 |
ACVR2A |
0.801 | -0.026 | -2 | 0.853 |
MEKK6 |
0.801 | 0.187 | 1 | 0.781 |
TLK2 |
0.801 | -0.057 | 1 | 0.702 |
MINK |
0.800 | 0.191 | 1 | 0.788 |
TAO2 |
0.800 | 0.096 | 2 | 0.813 |
DYRK1B |
0.800 | 0.045 | 1 | 0.634 |
MEK5 |
0.800 | -0.088 | 2 | 0.764 |
PAK5 |
0.800 | 0.009 | -2 | 0.659 |
TNIK |
0.799 | 0.195 | 3 | 0.823 |
MOK |
0.799 | 0.130 | 1 | 0.738 |
SGK1 |
0.799 | 0.099 | -3 | 0.576 |
ACVR2B |
0.799 | -0.037 | -2 | 0.861 |
ALK2 |
0.798 | -0.034 | -2 | 0.855 |
MAP3K15 |
0.798 | 0.161 | 1 | 0.765 |
NEK4 |
0.798 | 0.085 | 1 | 0.775 |
HPK1 |
0.798 | 0.170 | 1 | 0.782 |
CK1G1 |
0.798 | 0.011 | -3 | 0.491 |
CK1E |
0.797 | -0.012 | -3 | 0.507 |
SMMLCK |
0.797 | -0.012 | -3 | 0.764 |
P38D |
0.797 | 0.055 | 1 | 0.543 |
PLK3 |
0.797 | -0.112 | 2 | 0.688 |
DYRK4 |
0.797 | 0.036 | 1 | 0.610 |
PDK1 |
0.797 | 0.062 | 1 | 0.795 |
MEKK3 |
0.797 | -0.097 | 1 | 0.789 |
BRAF |
0.797 | -0.065 | -4 | 0.842 |
KHS1 |
0.797 | 0.201 | 1 | 0.785 |
CDK6 |
0.796 | 0.073 | 1 | 0.608 |
DRAK1 |
0.796 | -0.093 | 1 | 0.706 |
NEK11 |
0.796 | 0.013 | 1 | 0.778 |
GCK |
0.796 | 0.134 | 1 | 0.777 |
LKB1 |
0.796 | 0.042 | -3 | 0.826 |
KHS2 |
0.796 | 0.202 | 1 | 0.782 |
PAK4 |
0.795 | -0.002 | -2 | 0.655 |
YSK1 |
0.795 | 0.179 | 2 | 0.794 |
NEK1 |
0.794 | 0.123 | 1 | 0.775 |
TLK1 |
0.794 | -0.082 | -2 | 0.860 |
BUB1 |
0.794 | 0.097 | -5 | 0.769 |
LOK |
0.793 | 0.061 | -2 | 0.785 |
TTBK1 |
0.792 | -0.133 | 2 | 0.606 |
MRCKB |
0.792 | 0.069 | -3 | 0.690 |
ROCK2 |
0.792 | 0.100 | -3 | 0.742 |
PINK1 |
0.792 | -0.146 | 1 | 0.744 |
EEF2K |
0.792 | 0.066 | 3 | 0.813 |
GSK3B |
0.792 | 0.004 | 4 | 0.424 |
CAMK1D |
0.791 | -0.017 | -3 | 0.649 |
NEK3 |
0.791 | 0.102 | 1 | 0.772 |
NEK8 |
0.791 | -0.086 | 2 | 0.793 |
PBK |
0.791 | 0.087 | 1 | 0.733 |
CAMKK2 |
0.790 | -0.043 | -2 | 0.762 |
CK1D |
0.790 | -0.011 | -3 | 0.468 |
CDK4 |
0.789 | 0.047 | 1 | 0.583 |
MRCKA |
0.789 | 0.061 | -3 | 0.703 |
CHK2 |
0.789 | 0.009 | -3 | 0.606 |
DAPK3 |
0.788 | 0.015 | -3 | 0.754 |
LRRK2 |
0.788 | 0.026 | 2 | 0.821 |
GSK3A |
0.788 | 0.027 | 4 | 0.429 |
BMPR1A |
0.788 | -0.013 | 1 | 0.667 |
GAK |
0.788 | -0.009 | 1 | 0.778 |
CK1A2 |
0.788 | -0.015 | -3 | 0.464 |
CAMKK1 |
0.788 | -0.102 | -2 | 0.775 |
MST2 |
0.788 | 0.023 | 1 | 0.783 |
IRAK1 |
0.787 | -0.194 | -1 | 0.634 |
PASK |
0.786 | -0.068 | -3 | 0.804 |
GRK2 |
0.786 | -0.123 | -2 | 0.716 |
JNK1 |
0.785 | 0.021 | 1 | 0.579 |
CAMK1A |
0.785 | 0.003 | -3 | 0.626 |
MST1 |
0.784 | 0.027 | 1 | 0.779 |
SBK |
0.783 | 0.032 | -3 | 0.548 |
DMPK1 |
0.782 | 0.085 | -3 | 0.709 |
DAPK1 |
0.781 | -0.005 | -3 | 0.736 |
PKG1 |
0.781 | 0.006 | -2 | 0.594 |
CRIK |
0.780 | 0.079 | -3 | 0.677 |
MYO3B |
0.780 | 0.150 | 2 | 0.821 |
VRK1 |
0.780 | -0.078 | 2 | 0.774 |
MEK2 |
0.779 | -0.058 | 2 | 0.749 |
ROCK1 |
0.779 | 0.076 | -3 | 0.705 |
SLK |
0.779 | -0.033 | -2 | 0.729 |
STK33 |
0.779 | -0.115 | 2 | 0.577 |
TAK1 |
0.778 | -0.090 | 1 | 0.755 |
RIPK2 |
0.776 | -0.185 | 1 | 0.747 |
TAO1 |
0.774 | 0.069 | 1 | 0.746 |
MYO3A |
0.773 | 0.106 | 1 | 0.754 |
HASPIN |
0.773 | -0.018 | -1 | 0.595 |
PKMYT1_TYR |
0.773 | 0.249 | 3 | 0.807 |
LIMK2_TYR |
0.772 | 0.168 | -3 | 0.846 |
PDHK3_TYR |
0.772 | 0.094 | 4 | 0.865 |
CK2A2 |
0.771 | -0.056 | 1 | 0.622 |
GRK3 |
0.770 | -0.121 | -2 | 0.675 |
ASK1 |
0.769 | 0.021 | 1 | 0.752 |
TTK |
0.768 | 0.002 | -2 | 0.861 |
TESK1_TYR |
0.768 | 0.035 | 3 | 0.832 |
BIKE |
0.768 | 0.027 | 1 | 0.674 |
MAP2K4_TYR |
0.765 | 0.066 | -1 | 0.774 |
OSR1 |
0.763 | -0.048 | 2 | 0.747 |
PLK2 |
0.763 | -0.121 | -3 | 0.673 |
MAP2K7_TYR |
0.762 | -0.044 | 2 | 0.793 |
AAK1 |
0.762 | 0.089 | 1 | 0.589 |
TNNI3K_TYR |
0.760 | 0.141 | 1 | 0.790 |
LIMK1_TYR |
0.760 | 0.012 | 2 | 0.811 |
CK2A1 |
0.760 | -0.071 | 1 | 0.606 |
PINK1_TYR |
0.759 | -0.074 | 1 | 0.795 |
TYK2 |
0.758 | 0.006 | 1 | 0.783 |
JAK1 |
0.758 | 0.126 | 1 | 0.766 |
MAP2K6_TYR |
0.758 | -0.064 | -1 | 0.762 |
PDHK4_TYR |
0.756 | -0.081 | 2 | 0.797 |
ROS1 |
0.756 | 0.000 | 3 | 0.751 |
TNK2 |
0.755 | 0.044 | 3 | 0.731 |
JAK2 |
0.754 | -0.013 | 1 | 0.785 |
BMPR2_TYR |
0.754 | -0.071 | -1 | 0.727 |
RET |
0.754 | -0.101 | 1 | 0.783 |
YANK3 |
0.753 | -0.069 | 2 | 0.373 |
EPHA6 |
0.753 | -0.046 | -1 | 0.670 |
MST1R |
0.753 | -0.085 | 3 | 0.780 |
TYRO3 |
0.753 | -0.083 | 3 | 0.767 |
TNK1 |
0.752 | 0.028 | 3 | 0.746 |
PDHK1_TYR |
0.751 | -0.161 | -1 | 0.743 |
NEK10_TYR |
0.751 | 0.023 | 1 | 0.711 |
DDR1 |
0.750 | -0.102 | 4 | 0.787 |
ABL2 |
0.748 | -0.018 | -1 | 0.670 |
CSF1R |
0.748 | -0.085 | 3 | 0.753 |
CK1A |
0.748 | -0.047 | -3 | 0.379 |
ABL1 |
0.748 | -0.006 | -1 | 0.669 |
FGR |
0.747 | -0.070 | 1 | 0.797 |
EPHB4 |
0.747 | -0.095 | -1 | 0.659 |
JAK3 |
0.745 | -0.112 | 1 | 0.774 |
YES1 |
0.744 | -0.094 | -1 | 0.705 |
PDGFRB |
0.744 | -0.112 | 3 | 0.772 |
STLK3 |
0.743 | -0.163 | 1 | 0.733 |
HCK |
0.742 | -0.103 | -1 | 0.659 |
LCK |
0.741 | -0.049 | -1 | 0.652 |
INSRR |
0.741 | -0.129 | 3 | 0.729 |
ALPHAK3 |
0.741 | -0.176 | -1 | 0.643 |
TXK |
0.740 | -0.048 | 1 | 0.749 |
BLK |
0.739 | -0.026 | -1 | 0.663 |
AXL |
0.739 | -0.120 | 3 | 0.739 |
KDR |
0.738 | -0.111 | 3 | 0.727 |
ITK |
0.738 | -0.098 | -1 | 0.641 |
FLT3 |
0.738 | -0.142 | 3 | 0.762 |
FGFR1 |
0.738 | -0.141 | 3 | 0.743 |
PDGFRA |
0.737 | -0.147 | 3 | 0.768 |
FGFR2 |
0.737 | -0.180 | 3 | 0.769 |
WEE1_TYR |
0.737 | -0.088 | -1 | 0.632 |
FER |
0.736 | -0.201 | 1 | 0.772 |
MERTK |
0.735 | -0.119 | 3 | 0.735 |
ALK |
0.735 | -0.120 | 3 | 0.710 |
BTK |
0.734 | -0.171 | -1 | 0.624 |
LTK |
0.734 | -0.110 | 3 | 0.728 |
KIT |
0.734 | -0.173 | 3 | 0.756 |
EPHB1 |
0.734 | -0.171 | 1 | 0.779 |
EPHB3 |
0.733 | -0.152 | -1 | 0.640 |
DDR2 |
0.733 | -0.031 | 3 | 0.725 |
SRMS |
0.733 | -0.180 | 1 | 0.763 |
TEK |
0.732 | -0.194 | 3 | 0.714 |
TEC |
0.732 | -0.116 | -1 | 0.601 |
BMX |
0.732 | -0.101 | -1 | 0.572 |
EPHA1 |
0.731 | -0.118 | 3 | 0.741 |
MET |
0.731 | -0.141 | 3 | 0.748 |
EPHA4 |
0.730 | -0.162 | 2 | 0.680 |
EPHB2 |
0.730 | -0.159 | -1 | 0.627 |
CK1G3 |
0.729 | -0.056 | -3 | 0.333 |
INSR |
0.728 | -0.156 | 3 | 0.711 |
NTRK2 |
0.727 | -0.198 | 3 | 0.707 |
PTK6 |
0.727 | -0.210 | -1 | 0.598 |
PTK2B |
0.727 | -0.088 | -1 | 0.636 |
NTRK1 |
0.726 | -0.214 | -1 | 0.673 |
EPHA7 |
0.724 | -0.154 | 2 | 0.691 |
NTRK3 |
0.724 | -0.147 | -1 | 0.633 |
FRK |
0.724 | -0.166 | -1 | 0.658 |
FGFR3 |
0.723 | -0.211 | 3 | 0.744 |
EPHA3 |
0.723 | -0.185 | 2 | 0.662 |
LYN |
0.722 | -0.151 | 3 | 0.684 |
FYN |
0.722 | -0.129 | -1 | 0.632 |
FLT1 |
0.722 | -0.204 | -1 | 0.642 |
FLT4 |
0.722 | -0.220 | 3 | 0.719 |
ERBB2 |
0.722 | -0.216 | 1 | 0.721 |
YANK2 |
0.720 | -0.091 | 2 | 0.382 |
MATK |
0.719 | -0.159 | -1 | 0.614 |
SRC |
0.718 | -0.141 | -1 | 0.650 |
MUSK |
0.718 | -0.133 | 1 | 0.645 |
EGFR |
0.712 | -0.159 | 1 | 0.634 |
CSK |
0.712 | -0.202 | 2 | 0.695 |
EPHA8 |
0.711 | -0.185 | -1 | 0.618 |
EPHA5 |
0.711 | -0.202 | 2 | 0.652 |
FGFR4 |
0.711 | -0.172 | -1 | 0.613 |
IGF1R |
0.708 | -0.185 | 3 | 0.651 |
PTK2 |
0.706 | -0.121 | -1 | 0.588 |
CK1G2 |
0.700 | -0.088 | -3 | 0.417 |
EPHA2 |
0.699 | -0.204 | -1 | 0.574 |
ERBB4 |
0.697 | -0.154 | 1 | 0.617 |
SYK |
0.697 | -0.170 | -1 | 0.578 |
FES |
0.696 | -0.182 | -1 | 0.562 |
ZAP70 |
0.684 | -0.124 | -1 | 0.548 |