Motif 828 (n=192)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A4D1P6 | WDR91 | S326 | ochoa | WD repeat-containing protein 91 | Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May play a role in meiosis (By similarity). {ECO:0000250|UniProtKB:Q7TMQ7, ECO:0000269|PubMed:26783301, ECO:0000269|PubMed:27126989}. |
| A6NHS7 | MANSC4 | S20 | ochoa | MANSC domain-containing protein 4 | None |
| A6NMZ7 | COL6A6 | S816 | ochoa | Collagen alpha-6(VI) chain | Collagen VI acts as a cell-binding protein. {ECO:0000250}. |
| A8MTJ3 | GNAT3 | S47 | ochoa | Guanine nucleotide-binding protein G(t) subunit alpha-3 (Gustducin alpha-3 chain) | Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction (PubMed:38600377, PubMed:38776963). Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP-phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultimately leading to release of neurotransmitter. Indeed, denatonium and strychnine induce transient reduction in cAMP and cGMP in taste tissue, whereas this decrease is inhibited by GNAT3 antibody. Gustducin heterotrimer transduces response to bitter and sweet compounds via regulation of phosphodiesterase for alpha subunit, as well as via activation of phospholipase C for beta and gamma subunits, with ultimate increase inositol trisphosphate and increase of intracellular Calcium. GNAT3 can functionally couple to taste receptors to transmit intracellular signal: receptor heterodimer TAS1R2/TAS1R3 senses sweetness and TAS1R1/TAS1R3 transduces umami taste, whereas the T2R family GPCRs such as TAS2R14 act as bitter sensors (PubMed:38600377, PubMed:38776963). Also functions as lumenal sugar sensors in the gut to control the expression of the Na+-glucose transporter SGLT1 in response to dietaty sugar, as well as the secretion of Glucagon-like peptide-1, GLP-1 and glucose-dependent insulinotropic polypeptide, GIP. Thus, may modulate the gut capacity to absorb sugars, with implications in malabsorption syndromes and diet-related disorders including diabetes and obesity. {ECO:0000269|PubMed:11917125, ECO:0000269|PubMed:17724330, ECO:0000269|PubMed:38600377, ECO:0000269|PubMed:38776963}. |
| H3BQZ7 | HNRNPUL2-BSCL2 | S543 | ochoa | Heterogeneous nuclear ribonucleoprotein U-like protein 2 | None |
| O00192 | ARVCF | S871 | ochoa | Splicing regulator ARVCF (Armadillo repeat protein deleted in velo-cardio-facial syndrome) | Contributes to the regulation of alternative splicing of pre-mRNAs. {ECO:0000269|PubMed:24644279}. |
| O00533 | CHL1 | S1127 | ochoa | Neural cell adhesion molecule L1-like protein (Close homolog of L1) [Cleaved into: Processed neural cell adhesion molecule L1-like protein] | Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane (By similarity). {ECO:0000250}. |
| O14966 | RAB29 | S177 | ochoa | Ras-related protein Rab-7L1 (Rab-7-like protein 1) (Ras-related protein Rab-29) | The small GTPases Rab are key regulators in vesicle trafficking (PubMed:24788816). Essential for maintaining the integrity of the endosome-trans-Golgi network structure (By similarity). Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:24788816). Recruits LRRK2 to the Golgi complex and stimulates LRRK2 kinase activity (PubMed:29212815, PubMed:38127736). Stimulates phosphorylation of RAB10 'Thr-73' by LRRK2 (PubMed:38127736). Regulates neuronal process morphology in the intact central nervous system (CNS) (By similarity). May play a role in the formation of typhoid toxin transport intermediates during Salmonella enterica serovar Typhi (S.typhi) epithelial cell infection (PubMed:22042847). {ECO:0000250|UniProtKB:Q63481, ECO:0000269|PubMed:22042847, ECO:0000269|PubMed:24788816, ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:38127736}. |
| O14976 | GAK | S182 | ochoa | Cyclin-G-associated kinase (EC 2.7.11.1) (DnaJ homolog subfamily C member 26) | Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 (PubMed:10625686). May play a role in clathrin-mediated endocytosis and intracellular trafficking, and in the dynamics of clathrin assembly/disassembly (PubMed:18489706). {ECO:0000269|PubMed:10625686, ECO:0000269|PubMed:18489706}. |
| O15042 | U2SURP | S485 | ochoa | U2 snRNP-associated SURP motif-containing protein (140 kDa Ser/Arg-rich domain protein) (U2-associated protein SR140) | None |
| O15151 | MDM4 | S403 | psp | Protein Mdm4 (Double minute 4 protein) (Mdm2-like p53-binding protein) (Protein Mdmx) (p53-binding protein Mdm4) | Along with MDM2, contributes to TP53 regulation (PubMed:32300648). Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions. {ECO:0000269|PubMed:16163388, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:32300648}. |
| O15350 | TP73 | S388 | psp | Tumor protein p73 (p53-like transcription factor) (p53-related protein) | Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. Is an activator of FOXJ1 expression (By similarity). It is an essential factor for the positive regulation of lung ciliated cell differentiation (PubMed:34077761). {ECO:0000250|UniProtKB:Q9JJP2, ECO:0000269|PubMed:10203277, ECO:0000269|PubMed:11753569, ECO:0000269|PubMed:18174154, ECO:0000269|PubMed:34077761}. |
| O43264 | ZW10 | S103 | ochoa | Centromere/kinetochore protein zw10 homolog | Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:11590237, PubMed:15485811, PubMed:15824131). Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the interphase NRZ complex which is believed to play a role in SNARE assembly at the ER (PubMed:15029241). {ECO:0000269|PubMed:11590237, ECO:0000269|PubMed:15029241, ECO:0000269|PubMed:15094189, ECO:0000269|PubMed:15485811, ECO:0000269|PubMed:15824131, ECO:0000305}. |
| O43312 | MTSS1 | S322 | psp | Protein MTSS 1 (Metastasis suppressor YGL-1) (Metastasis suppressor protein 1) (Missing in metastasis protein) | May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton. |
| O60361 | NME2P1 | S84 | ochoa | Putative nucleoside diphosphate kinase (NDK) (NDP kinase) (EC 2.7.4.6) | Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). {ECO:0000250}. |
| O60741 | HCN1 | S599 | psp | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1) | Hyperpolarization-activated ion channel that are permeable to sodium and potassium ions (PubMed:15351778, PubMed:28086084). Displays lower selectivity for K(+) over Na(+) ions (PubMed:28086084). Contributes to the native pacemaker currents in heart (If) and in the generation of the I(h) current which controls neuron excitability (PubMed:29936235, PubMed:30351409). Participates in cerebellar mechanisms of motor learning (By similarity). May mediate responses to sour stimuli (By similarity). {ECO:0000250|UniProtKB:O88704, ECO:0000269|PubMed:15351778, ECO:0000269|PubMed:28086084, ECO:0000269|PubMed:29936235, ECO:0000269|PubMed:30351409}. |
| O75563 | SKAP2 | S313 | ochoa | Src kinase-associated phosphoprotein 2 (Pyk2/RAFTK-associated protein) (Retinoic acid-induced protein 70) (SKAP55 homolog) (SKAP-55HOM) (SKAP-HOM) (Src family-associated phosphoprotein 2) (Src kinase-associated phosphoprotein 55-related protein) (Src-associated adapter protein with PH and SH3 domains) | May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway. {ECO:0000269|PubMed:12893833, ECO:0000269|PubMed:9837776}. |
| O75762 | TRPA1 | S86 | psp | Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Transformation-sensitive protein p120) (p120) (Wasabi receptor) | Ligand-activated Ca(2+)-permeable, nonselective cation channel involved in pain detection and possibly also in cold perception, oxygen concentration perception, cough, itch, and inner ear function (PubMed:17259981, PubMed:21195050, PubMed:21873995, PubMed:23199233, PubMed:25389312, PubMed:33152265). Has a relatively high Ca(2+) selectivity, with a preference for divalent over monovalent cations (Ca(2+) > Ba(2+) > Mg(2+) > NH4(+) > Li(+) > K(+)), the influx of cation into the cytoplasm leads to membrane depolarization (PubMed:19202543, PubMed:21195050). Has a central role in the pain response to endogenous inflammatory mediators, such as bradykinin and to a diverse array of irritants. Activated by a large variety of structurally unrelated electrophilic and non-electrophilic chemical compounds, such as allylthiocyanate (AITC) from mustard oil or wasabi, cinnamaldehyde, diallyl disulfide (DADS) from garlic, and acrolein, an environmental irritant (PubMed:20547126, PubMed:25389312, PubMed:27241698, PubMed:30878828). Electrophilic ligands activate TRPA1 by interacting with critical N-terminal Cys residues in a covalent manner (PubMed:17164327, PubMed:27241698, PubMed:31866091, PubMed:32641835). Non-electrophile agonists bind at distinct sites in the transmembrane domain to promote channel activation (PubMed:33152265). Also acts as an ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana (PubMed:25389312). May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds (By similarity). {ECO:0000250|UniProtKB:Q8BLA8, ECO:0000269|PubMed:17164327, ECO:0000269|PubMed:17259981, ECO:0000269|PubMed:19202543, ECO:0000269|PubMed:20547126, ECO:0000269|PubMed:21195050, ECO:0000269|PubMed:21873995, ECO:0000269|PubMed:23199233, ECO:0000269|PubMed:25389312, ECO:0000269|PubMed:27241698, ECO:0000269|PubMed:30878828, ECO:0000269|PubMed:31866091, ECO:0000269|PubMed:32641835, ECO:0000269|PubMed:33152265}. |
| O94804 | STK10 | S20 | ochoa | Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase) | Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. {ECO:0000269|PubMed:11903060, ECO:0000269|PubMed:12639966, ECO:0000269|PubMed:19255442}. |
| O94832 | MYO1D | S298 | ochoa | Unconventional myosin-Id | Unconventional myosin that functions as actin-based motor protein with ATPase activity (By similarity). Plays a role in endosomal protein trafficking, and especially in the transfer of cargo proteins from early to recycling endosomes (By similarity). Required for normal planar cell polarity in ciliated tracheal cells, for normal rotational polarity of cilia, and for coordinated, unidirectional ciliary movement in the trachea. Required for normal, polarized cilia organization in brain ependymal epithelial cells (By similarity). {ECO:0000250|UniProtKB:F1PRN2, ECO:0000250|UniProtKB:Q63357}. |
| O94880 | PHF14 | S29 | ochoa | PHD finger protein 14 | Histone-binding protein (PubMed:23688586). Binds preferentially to unmodified histone H3 but can also bind to a lesser extent to histone H3 trimethylated at 'Lys-9' (H3K9me3) as well as to histone H3 monomethylated at 'Lys-27' (H3K27ac) and trimethylated at 'Lys-27' (H3K27me3) (By similarity). Represses PDGFRA expression, thus playing a role in regulation of mesenchymal cell proliferation (By similarity). Suppresses the expression of CDKN1A/p21 by reducing the level of trimethylation of histone H3 'Lys-4', leading to enhanced proliferation of germinal center B cells (By similarity). {ECO:0000250|UniProtKB:A0A286Y9D1, ECO:0000250|UniProtKB:Q9D4H9, ECO:0000269|PubMed:23688586}. |
| O94986 | CEP152 | S1430 | ochoa | Centrosomal protein of 152 kDa (Cep152) | Necessary for centrosome duplication; the function also seems to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). Acts as a molecular scaffold facilitating the interaction of PLK4 and CPAP, 2 molecules involved in centriole formation (PubMed:20852615, PubMed:21059844). Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure (PubMed:24997597). Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles (By similarity). Overexpression of CEP152 can drive amplification of centrioles (PubMed:20852615). {ECO:0000250|UniProtKB:A2AUM9, ECO:0000250|UniProtKB:Q498G2, ECO:0000269|PubMed:20852615, ECO:0000269|PubMed:21059844, ECO:0000269|PubMed:21131973}. |
| O95671 | ASMTL | S228 | ochoa | Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein [Includes: dTTP/UTP pyrophosphatase (dTTPase/UTPase) (EC 3.6.1.9) (Nucleoside triphosphate pyrophosphatase) (Nucleotide pyrophosphatase) (Nucleotide PPase); N-acetylserotonin O-methyltransferase-like protein (ASMTL) (EC 2.1.1.-)] | Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. Can also hydrolyze CTP and the modified nucleotides pseudo-UTP, 5-methyl-UTP (m(5)UTP) and 5-methyl-CTP (m(5)CTP). Has weak activity with dCTP, 8-oxo-GTP and N(4)-methyl-dCTP (PubMed:24210219). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids (PubMed:24210219). In addition, the presence of the putative catalytic domain of S-adenosyl-L-methionine binding in the C-terminal region argues for a methyltransferase activity (Probable). {ECO:0000269|PubMed:24210219, ECO:0000305}. |
| P00747 | PLG | S477 | ochoa | Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B] | Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1, C4 and C5 (PubMed:6447255). Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells. {ECO:0000269|PubMed:14699093, ECO:0000269|PubMed:6447255}.; FUNCTION: Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo. {ECO:0000269|PubMed:14699093}.; FUNCTION: (Microbial infection) ENO/enoloase from parasite P.falciparum (strain NF54) interacts with PLG present in the mosquito blood meal to promote the invasion of the mosquito midgut by the parasite ookinete (PubMed:21949403). The catalytic active form, plasmin, is essential for the invasion of the mosquito midgut (PubMed:21949403). {ECO:0000269|PubMed:21949403}.; FUNCTION: (Microbial infection) Binds to OspC on the surface of B.burgdorferi cells, possibly conferring an extracellular protease activity on the bacteria that allows it to traverse host tissue. {ECO:0000269|PubMed:22433849}.; FUNCTION: (Microbial infection) Interacts with dengue virus type 2 particles (PubMed:31726374). Enhances dengue virus type 2 infection in Aedes aegypti mosquito midgut by increasing midgut internalization, resulting in higher infection rates and viral dissemination in mosquitoes (PubMed:31726374). {ECO:0000269|PubMed:31726374}. |
| P02647 | APOA1 | S191 | ochoa | Apolipoprotein A-I (Apo-AI) (ApoA-I) (Apolipoprotein A1) [Cleaved into: Proapolipoprotein A-I (ProapoA-I); Truncated apolipoprotein A-I (Apolipoprotein A-I(1-242))] | Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. {ECO:0000269|PubMed:1909888}. |
| P04626 | ERBB2 | S1002 | ochoa | Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340) | Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. {ECO:0000305}.; FUNCTION: In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. {ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:15380516, ECO:0000269|PubMed:21555369}. |
| P04899 | GNAI2 | S47 | ochoa | Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein) | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division. {ECO:0000269|PubMed:17635935}.; FUNCTION: [Isoform sGi2]: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an intracellular pool. {ECO:0000269|PubMed:17550964}. |
| P05141 | SLC25A5 | S42 | ochoa | ADP/ATP translocase 2 (ADP,ATP carrier protein 2) (ADP,ATP carrier protein, fibroblast isoform) (Adenine nucleotide translocator 2) (ANT 2) (Solute carrier family 25 member 5) [Cleaved into: ADP/ATP translocase 2, N-terminally processed] | ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity). In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity (By similarity). Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis (By similarity). Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A5/ANT2 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity) (By similarity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it (By similarity). Probably mediates mitochondrial uncoupling in tissues that do not express UCP1 (By similarity). Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death (PubMed:31883789). It is however unclear if SLC25A5/ANT2 constitutes a pore-forming component of mPTP or regulates it (By similarity). Acts as a regulator of mitophagy independently of ADP:ATP antiporter activity: promotes mitophagy via interaction with TIMM44, leading to inhibit the presequence translocase TIMM23, thereby promoting stabilization of PINK1 (By similarity). As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation (PubMed:20797633). {ECO:0000250|UniProtKB:G2QNH0, ECO:0000250|UniProtKB:P51881, ECO:0000269|PubMed:20797633, ECO:0000269|PubMed:31883789}. |
| P05165 | PCCA | S252 | ochoa | Propionyl-CoA carboxylase alpha chain, mitochondrial (PCCase subunit alpha) (EC 6.4.1.3) (Propanoyl-CoA:carbon dioxide ligase subunit alpha) | This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites (PubMed:6765947, PubMed:8434582). Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA (PubMed:10101253, PubMed:6765947, PubMed:8434582). Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, while the beta subunit then transfers the carboxyl group from carboxylated biotin to propionyl-CoA (By similarity). Propionyl-CoA carboxylase also significantly acts on butyryl-CoA/butanoyl-CoA, which is converted to ethylmalonyl-CoA/(2S)-ethylmalonyl-CoA at a much lower rate (PubMed:6765947). Other alternative minor substrates include (2E)-butenoyl-CoA/crotonoyl-CoA (By similarity). {ECO:0000250|UniProtKB:P0DTA4, ECO:0000250|UniProtKB:Q5LUF3, ECO:0000269|PubMed:10101253, ECO:0000269|PubMed:6765947, ECO:0000269|PubMed:8434582}. |
| P06239 | LCK | S150 | ochoa | Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK) | Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules are recruited, ultimately leading to lymphokine production. LCK also contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, which leads to hyperphosphorylation and activation of LCK. Also plays a role in the IL2 receptor-linked signaling pathway that controls the T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Phosphorylates other substrates including RUNX3, PTK2B/PYK2, the microtubule-associated protein MAPT, RHOH or TYROBP. Interacts with FYB2 (PubMed:27335501). {ECO:0000269|PubMed:16339550, ECO:0000269|PubMed:16709819, ECO:0000269|PubMed:20028775, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:20851766, ECO:0000269|PubMed:21269457, ECO:0000269|PubMed:22080863, ECO:0000269|PubMed:27335501, ECO:0000269|PubMed:38614099}. |
| P06730 | EIF4E | S53 | psp | Eukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (eIF-4F 25 kDa subunit) (mRNA cap-binding protein) | Acts in the cytoplasm to initiate and regulate protein synthesis and is required in the nucleus for export of a subset of mRNAs from the nucleus to the cytoplasm which promotes processes such as RNA capping, processing and splicing (PubMed:11606200, PubMed:22578813, PubMed:22684010, PubMed:24335285, PubMed:29987188). Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (By similarity). This protein recognizes and binds the 7-methylguanosine (m7G)-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures (PubMed:16271312, PubMed:22578813). Together with EIF4G1, antagonizes the scanning promoted by EIF1-EIF4G1 and is required for TISU translation, a process where the TISU element recognition makes scanning unnecessary (PubMed:29987188). In addition to its role in translation initiation, also acts as a regulator of translation and stability in the cytoplasm (PubMed:24335285). Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression: in the complex, EIF4E mediates the binding to the mRNA cap (By similarity). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). In P-bodies, component of a complex that mediates the storage of translationally inactive mRNAs in the cytoplasm and prevents their degradation (PubMed:24335285). May play an important role in spermatogenesis through translational regulation of stage-specific mRNAs during germ cell development (By similarity). As well as its roles in translation, also involved in mRNA nucleocytoplasmic transport (By similarity). Its role in mRNA export from the nucleus to the cytoplasm relies on its ability to bind the m7G cap of RNAs and on the presence of the 50-nucleotide EIF4E sensitivity element (4ESE) in the 3'UTR of sensitive transcripts (By similarity). Interaction with the 4ESE is mediated by LRPPRC which binds simultaneously to both EIF4E and the 4ESE, thereby acting as a platform for assembly for the RNA export complex (By similarity). EIF4E-dependent mRNA export is independent of ongoing protein or RNA synthesis and is also NFX1-independent but is XPO1-dependent with LRPPRC interacting with XPO1 to form an EIF4E-dependent mRNA export complex (By similarity). Alters the composition of the cytoplasmic face of the nuclear pore to promote RNA export by reducing RANBP2 expression, relocalizing nucleoporin NUP214 and increasing expression of RANBP1 and RNA export factors DDX19 and GLE1 (By similarity). Promotes the nuclear export of cyclin CCND1 mRNA (By similarity). Promotes the nuclear export of NOS2/iNOS mRNA (PubMed:23471078). Promotes the nuclear export of MDM2 mRNA (PubMed:22684010). Promotes the export of additional mRNAs, including others involved in the cell cycle (By similarity). In the nucleus, binds to capped splice factor-encoding mRNAs and stimulates their nuclear export to enhance splice factor production by increasing their cytoplasmic availability to the translation machinery (By similarity). May also regulate splicing through interaction with the spliceosome in an RNA and m7G cap-dependent manner (By similarity). Also binds to some pre-mRNAs and may play a role in their recruitment to the spliceosome (By similarity). Promotes steady-state capping of a subset of coding and non-coding RNAs by mediating nuclear export of capping machinery mRNAs including RNMT, RNGTT and RAMAC to enhance their translation (By similarity). Stimulates mRNA 3'-end processing by promoting the expression of several core cleavage complex factors required for mRNA cleavage and polyadenylation, and may also have a direct effect through its interaction with the CPSF3 cleavage enzyme (By similarity). Rescues cells from apoptosis by promoting activation of serine/threonine-protein kinase AKT1 through mRNA export of NBS1 which potentiates AKT1 phosphorylation and also through mRNA export of AKT1 effectors, allowing for increased production of these proteins (By similarity). {ECO:0000250|UniProtKB:P63073, ECO:0000250|UniProtKB:P63074, ECO:0000269|PubMed:11606200, ECO:0000269|PubMed:16271312, ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:22684010, ECO:0000269|PubMed:23471078, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:29987188}. |
| P07199 | CENPB | S307 | ochoa | Major centromere autoantigen B (Centromere protein B) (CENP-B) | Interacts with centromeric heterochromatin in chromosomes and binds to a specific 17 bp subset of alphoid satellite DNA, called the CENP-B box (PubMed:11726497). May organize arrays of centromere satellite DNA into a higher-order structure which then directs centromere formation and kinetochore assembly in mammalian chromosomes (Probable). {ECO:0000269|PubMed:11726497, ECO:0000305}. |
| P07737 | PFN1 | S72 | psp | Profilin-1 (Epididymis tissue protein Li 184a) (Profilin I) | Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR. {ECO:0000269|PubMed:18573880}. |
| P07814 | EPRS1 | S434 | ochoa | Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)] | Multifunctional protein which primarily functions within the aminoacyl-tRNA synthetase multienzyme complex, also known as multisynthetase complex. Within the complex it catalyzes the attachment of both L-glutamate and L-proline to their cognate tRNAs in a two-step reaction where the amino acid is first activated by ATP to form a covalent intermediate with AMP. Subsequently, the activated amino acid is transferred to the acceptor end of the cognate tRNA to form L-glutamyl-tRNA(Glu) and L-prolyl-tRNA(Pro) (PubMed:23263184, PubMed:24100331, PubMed:29576217, PubMed:3290852, PubMed:37212275). Upon interferon-gamma stimulation, EPRS1 undergoes phosphorylation, causing its dissociation from the aminoacyl-tRNA synthetase multienzyme complex. It is recruited to form the GAIT complex, which binds to stem loop-containing GAIT elements found in the 3'-UTR of various inflammatory mRNAs, such as ceruloplasmin. The GAIT complex inhibits the translation of these mRNAs, allowing interferon-gamma to redirect the function of EPRS1 from protein synthesis to translation inhibition in specific cell contexts (PubMed:15479637, PubMed:23071094). Furthermore, it can function as a downstream effector in the mTORC1 signaling pathway, by promoting the translocation of SLC27A1 from the cytoplasm to the plasma membrane where it mediates the uptake of long-chain fatty acid by adipocytes. Thereby, EPRS1 also plays a role in fat metabolism and more indirectly influences lifespan (PubMed:28178239). {ECO:0000269|PubMed:15479637, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:28178239, ECO:0000269|PubMed:29576217, ECO:0000269|PubMed:3290852, ECO:0000269|PubMed:37212275}. |
| P07954 | FH | S366 | ochoa | Fumarate hydratase, mitochondrial (Fumarase) (HsFH) (EC 4.2.1.2) | Catalyzes the reversible stereospecific interconversion of fumarate to L-malate (PubMed:30761759). Experiments in other species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable). {ECO:0000269|PubMed:30761759, ECO:0000305}.; FUNCTION: [Isoform Mitochondrial]: Catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH. {ECO:0000250|UniProtKB:P10173}.; FUNCTION: [Isoform Cytoplasmic]: Catalyzes the dehydration of L-malate to fumarate (By similarity). Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism (By similarity). Also plays a role in DNA repair by promoting non-homologous end-joining (NHEJ) (PubMed:20231875, PubMed:26237645). In response to DNA damage and phosphorylation by PRKDC, translocates to the nucleus and accumulates at DNA double-strand breaks (DSBs): acts by catalyzing formation of fumarate, an inhibitor of KDM2B histone demethylase activity, resulting in enhanced dimethylation of histone H3 'Lys-36' (H3K36me2) (PubMed:26237645). {ECO:0000250|UniProtKB:P97807, ECO:0000269|PubMed:20231875, ECO:0000269|PubMed:26237645}. |
| P08240 | SRPRA | S46 | ochoa | Signal recognition particle receptor subunit alpha (SR-alpha) (Docking protein alpha) (DP-alpha) | Component of the signal recognition particle (SRP) complex receptor (SR) (PubMed:16439358). Ensures, in conjunction with the SRP complex, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (PubMed:16675701, PubMed:34020957). Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SRP subunit SRP54 (PubMed:34020957). SRP receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER (PubMed:34020957). {ECO:0000269|PubMed:16439358, ECO:0000269|PubMed:16675701, ECO:0000269|PubMed:34020957}. |
| P08514 | ITGA2B | S432 | ochoa | Integrin alpha-IIb (GPalpha IIb) (GPIIb) (Platelet membrane glycoprotein IIb) (CD antigen CD41) [Cleaved into: Integrin alpha-IIb heavy chain; Integrin alpha-IIb light chain, form 1; Integrin alpha-IIb light chain, form 2] | Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain (By similarity). Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen (PubMed:9111081). This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface (By similarity). {ECO:0000250|UniProtKB:O54890, ECO:0000269|PubMed:9111081}. |
| P08754 | GNAI3 | S47 | ochoa | Guanine nucleotide-binding protein G(i) subunit alpha-3 (G(i) alpha-3) | Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (By similarity). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:18434541, PubMed:19478087, PubMed:8774883). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (PubMed:19478087). Stimulates the activity of receptor-regulated K(+) channels (PubMed:2535845). The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division (PubMed:17635935). The active GTP-bound form activates the calcium permeant TRPC5 ion channels (PubMed:37137991). {ECO:0000250|UniProtKB:P08753, ECO:0000269|PubMed:17635935, ECO:0000269|PubMed:18434541, ECO:0000269|PubMed:2535845, ECO:0000269|PubMed:37137991, ECO:0000269|PubMed:8774883}. |
| P09211 | GSTP1 | S135 | ochoa | Glutathione S-transferase P (EC 2.5.1.18) (GST class-pi) (GSTP1-1) | Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). Participates in the formation of novel hepoxilin regioisomers (PubMed:21046276). Negatively regulates CDK5 activity via p25/p35 translocation to prevent neurodegeneration. {ECO:0000269|PubMed:21046276, ECO:0000269|PubMed:21668448, ECO:0000269|PubMed:9084911}. |
| P09471 | GNAO1 | S47 | ochoa | Guanine nucleotide-binding protein G(o) subunit alpha (EC 3.6.5.-) | Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades (PubMed:29925951, PubMed:33408414). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (By similarity). Signaling by an activated GPCR promotes GDP release and GTP binding (By similarity). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (By similarity). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (By similarity). Signaling is mediated via effector proteins, such as adenylate cyclase (By similarity). Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (By similarity). {ECO:0000250|UniProtKB:P18872, ECO:0000269|PubMed:29925951, ECO:0000269|PubMed:33408414}. |
| P10721 | KIT | S821 | psp | Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117) | Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1. {ECO:0000269|PubMed:10397721, ECO:0000269|PubMed:12444928, ECO:0000269|PubMed:12511554, ECO:0000269|PubMed:12878163, ECO:0000269|PubMed:17904548, ECO:0000269|PubMed:19265199, ECO:0000269|PubMed:21135090, ECO:0000269|PubMed:21640708, ECO:0000269|PubMed:7520444, ECO:0000269|PubMed:9528781}. |
| P11488 | GNAT1 | S43 | ochoa | Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) | Functions as a signal transducer for the rod photoreceptor RHO. Required for normal RHO-mediated light perception by the retina (PubMed:22190596). Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs), such as the photoreceptor RHO. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Activated RHO promotes GDP release and GTP binding. Signaling is mediated via downstream effector proteins, such as cGMP-phosphodiesterase (By similarity). {ECO:0000250|UniProtKB:P04695, ECO:0000269|PubMed:22190596}. |
| P12235 | SLC25A4 | S42 | ochoa | ADP/ATP translocase 1 (ADP,ATP carrier protein 1) (ADP,ATP carrier protein, heart/skeletal muscle isoform T1) (Adenine nucleotide translocator 1) (ANT 1) (Solute carrier family 25 member 4) | ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (PubMed:21586654, PubMed:27693233). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity). In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity (PubMed:31883789). Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis (By similarity). Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A4/ANT1 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity) (By similarity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it (By similarity). Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death (PubMed:31883789). It is however unclear if SLC25A4/ANT1 constitutes a pore-forming component of mPTP or regulates it (By similarity). Acts as a regulator of mitophagy independently of ADP:ATP antiporter activity: promotes mitophagy via interaction with TIMM44, leading to inhibit the presequence translocase TIMM23, thereby promoting stabilization of PINK1 (By similarity). {ECO:0000250|UniProtKB:G2QNH0, ECO:0000250|UniProtKB:P48962, ECO:0000269|PubMed:21586654, ECO:0000269|PubMed:27693233, ECO:0000269|PubMed:31883789}. |
| P12236 | SLC25A6 | S42 | ochoa | ADP/ATP translocase 3 (ADP,ATP carrier protein 3) (ADP,ATP carrier protein, isoform T2) (ANT 2) (Adenine nucleotide translocator 3) (ANT 3) (Solute carrier family 25 member 6) [Cleaved into: ADP/ATP translocase 3, N-terminally processed] | ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity). In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity (PubMed:15033708). Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis (By similarity). Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A6/ANT3 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity) (By similarity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it (By similarity). Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death (PubMed:15033708). It is however unclear if SLC25A6/ANT3 constitutes a pore-forming component of mPTP or regulates it (By similarity). {ECO:0000250|UniProtKB:G2QNH0, ECO:0000250|UniProtKB:P48962, ECO:0000269|PubMed:15033708}. |
| P13056 | NR2C1 | S90 | ochoa | Nuclear receptor subfamily 2 group C member 1 (Orphan nuclear receptor TR2) (Testicular receptor 2) | Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation. {ECO:0000269|PubMed:12093804, ECO:0000269|PubMed:17010934}. |
| P15531 | NME1 | S99 | ochoa | Nucleoside diphosphate kinase A (NDK A) (NDP kinase A) (EC 2.7.4.6) (Granzyme A-activated DNase) (GAAD) (Metastasis inhibition factor nm23) (NM23-H1) (Tumor metastatic process-associated protein) | Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair. {ECO:0000269|PubMed:12628186, ECO:0000269|PubMed:16818237, ECO:0000269|PubMed:8810265}. |
| P19087 | GNAT2 | S47 | ochoa | Guanine nucleotide-binding protein G(t) subunit alpha-2 (Transducin alpha-2 chain) | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase. |
| P20290 | BTF3 | S173 | ochoa | Transcription factor BTF3 (Nascent polypeptide-associated complex subunit beta) (NAC-beta) (RNA polymerase B transcription factor 3) | When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription. {ECO:0000269|PubMed:10982809}. |
| P21333 | FLNA | S2170 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P21462 | FPR1 | S328 | psp | fMet-Leu-Phe receptor (fMLP receptor) (N-formyl peptide receptor) (FPR) (N-formylpeptide chemoattractant receptor) | High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors (PubMed:10514456, PubMed:15153520, PubMed:2161213, PubMed:2176894). Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release (PubMed:15153520, PubMed:15210802, PubMed:1712023, PubMed:2161213). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:10514456, PubMed:1712023). Receptor for TAFA4, mediates its effects on chemoattracting macrophages, promoting phagocytosis and increasing ROS release (PubMed:25109685). Receptor for cathepsin CTSG, leading to increased phagocyte chemotaxis (PubMed:15210802). {ECO:0000269|PubMed:10514456, ECO:0000269|PubMed:15153520, ECO:0000269|PubMed:2161213, ECO:0000269|PubMed:2176894, ECO:0000269|PubMed:25109685, ECO:0000303|PubMed:10514456, ECO:0000303|PubMed:1712023, ECO:0000303|PubMed:2161213, ECO:0000303|PubMed:2176894}. |
| P22392 | NME2 | S99 | ochoa | Nucleoside diphosphate kinase B (NDK B) (NDP kinase B) (EC 2.7.4.6) (C-myc purine-binding transcription factor PUF) (Histidine protein kinase NDKB) (EC 2.7.13.3) (nm23-H2) | Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Negatively regulates Rho activity by interacting with AKAP13/LBC (PubMed:15249197). Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:19435876, PubMed:8392752). Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter. Does not bind to duplex NHE III(1) (PubMed:19435876). Has G-quadruplex (G4) DNA-binding activity, which is independent of its nucleotide-binding and kinase activity. Binds both folded and unfolded G4 with similar low nanomolar affinities. Stabilizes folded G4s regardless of whether they are prefolded or not (PubMed:25679041). Exhibits histidine protein kinase activity (PubMed:20946858). {ECO:0000250|UniProtKB:P36010, ECO:0000269|PubMed:15249197, ECO:0000269|PubMed:19435876, ECO:0000269|PubMed:20946858, ECO:0000269|PubMed:25679041, ECO:0000269|PubMed:8392752}. |
| P22415 | USF1 | S262 | psp | Upstream stimulatory factor 1 (Class B basic helix-loop-helix protein 11) (bHLHb11) (Major late transcription factor 1) | Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters. |
| P26640 | VARS1 | S617 | ochoa | Valine--tRNA ligase (EC 6.1.1.9) (Protein G7a) (Valyl-tRNA synthetase) (ValRS) | Catalyzes the attachment of valine to tRNA(Val). {ECO:0000269|PubMed:8428657}. |
| P27348 | YWHAQ | S214 | ochoa | 14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. {ECO:0000269|PubMed:12177059}. |
| P30301 | MIP | S235 | psp | Lens fiber major intrinsic protein (Aquaporin-0) (MIP26) (MP26) | Aquaporins form homotetrameric transmembrane channels, with each monomer independently mediating water transport across the plasma membrane along its osmotic gradient (PubMed:11001937, PubMed:24120416). Specifically expressed in lens fiber cells, this aquaporin is crucial for maintaining lens water homeostasis and transparency. Beyond water permeability, it also acts as a cell-to-cell adhesion molecule, forming thin junctions between lens fiber cells that are essential for maintaining the ordered structure and transparency of the lens (PubMed:24120416). {ECO:0000269|PubMed:11001937, ECO:0000269|PubMed:24120416}. |
| P31946 | YWHAB | S216 | ochoa | 14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed] | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13. {ECO:0000269|PubMed:17717073, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21224381}. |
| P31947 | SFN | S216 | ochoa | 14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Binding generally results in the modulation of the activity of the binding partner (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Promotes cytosolic retention of GBP1 GTPase by binding to phosphorylated GBP1, thereby inhibiting the innate immune response (PubMed:37797010). Also acts as a TP53/p53-regulated inhibitor of G2/M progression (PubMed:9659898). When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). Acts to maintain desmosome cell junction adhesion in epithelial cells via interacting with and sequestering PKP3 to the cytoplasm, thereby restricting its translocation to existing desmosome structures and therefore maintaining desmosome protein homeostasis (PubMed:24124604). Also acts to facilitate PKP3 exchange at desmosome plaques, thereby maintaining keratinocyte intercellular adhesion (PubMed:29678907). May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53 (PubMed:18382127). {ECO:0000250|UniProtKB:O70456, ECO:0000269|PubMed:15731107, ECO:0000269|PubMed:18382127, ECO:0000269|PubMed:22634725, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:28202711, ECO:0000269|PubMed:29678907, ECO:0000269|PubMed:37797010, ECO:0000269|PubMed:9659898}. |
| P34910 | EVI2B | S280 | ochoa | Protein EVI2B (Ecotropic viral integration site 2B protein homolog) (EVI-2B) (CD antigen CD361) | Required for granulocyte differentiation and functionality of hematopoietic progenitor cells through the control of cell cycle progression and survival of hematopoietic progenitor cells. {ECO:0000269|PubMed:28186500}. |
| P35372 | OPRM1 | S365 | psp | Mu-type opioid receptor (M-OR-1) (MOR-1) (Mu opiate receptor) (Mu opioid receptor) (MOP) (hMOP) | Receptor for endogenous opioids such as beta-endorphin and endomorphin (PubMed:10529478, PubMed:12589820, PubMed:7891175, PubMed:7905839, PubMed:7957926, PubMed:9689128). Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone (PubMed:10529478, PubMed:10836142, PubMed:12589820, PubMed:19300905, PubMed:7891175, PubMed:7905839, PubMed:7957926, PubMed:9689128). Also activated by enkephalin peptides, such as Met-enkephalin or Met-enkephalin-Arg-Phe, with higher affinity for Met-enkephalin-Arg-Phe (By similarity). Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors (PubMed:7905839). The agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1 isoforms Alpha-1 and Alpha-2, and to a lesser extent to pertussis toxin-insensitive G alpha proteins GNAZ and GNA15 (PubMed:12068084). They mediate an array of downstream cellular responses, including inhibition of adenylate cyclase activity and both N-type and L-type calcium channels, activation of inward rectifying potassium channels, mitogen-activated protein kinase (MAPK), phospholipase C (PLC), phosphoinositide/protein kinase (PKC), phosphoinositide 3-kinase (PI3K) and regulation of NF-kappa-B (By similarity). Also couples to adenylate cyclase stimulatory G alpha proteins (By similarity). The selective temporal coupling to G-proteins and subsequent signaling can be regulated by RGSZ proteins, such as RGS9, RGS17 and RGS4 (By similarity). Phosphorylation by members of the GPRK subfamily of Ser/Thr protein kinases and association with beta-arrestins is involved in short-term receptor desensitization (By similarity). Beta-arrestins associate with the GPRK-phosphorylated receptor and uncouple it from the G-protein thus terminating signal transduction (By similarity). The phosphorylated receptor is internalized through endocytosis via clathrin-coated pits which involves beta-arrestins (By similarity). The activation of the ERK pathway occurs either in a G-protein-dependent or a beta-arrestin-dependent manner and is regulated by agonist-specific receptor phosphorylation (By similarity). Acts as a class A G-protein coupled receptor (GPCR) which dissociates from beta-arrestin at or near the plasma membrane and undergoes rapid recycling (By similarity). Receptor down-regulation pathways are varying with the agonist and occur dependent or independent of G-protein coupling (By similarity). Endogenous ligands induce rapid desensitization, endocytosis and recycling (By similarity). Heterooligomerization with other GPCRs can modulate agonist binding, signaling and trafficking properties (By similarity). {ECO:0000250|UniProtKB:P33535, ECO:0000269|PubMed:10529478, ECO:0000269|PubMed:12068084, ECO:0000269|PubMed:12589820, ECO:0000269|PubMed:7891175, ECO:0000269|PubMed:7905839, ECO:0000269|PubMed:7957926, ECO:0000269|PubMed:9689128, ECO:0000303|PubMed:10836142, ECO:0000303|PubMed:19300905}.; FUNCTION: [Isoform 12]: Couples to GNAS and is proposed to be involved in excitatory effects. {ECO:0000269|PubMed:20525224}.; FUNCTION: [Isoform 16]: Does not bind agonists but may act through oligomerization with binding-competent OPRM1 isoforms and reduce their ligand binding activity. {ECO:0000269|PubMed:16580639}.; FUNCTION: [Isoform 17]: Does not bind agonists but may act through oligomerization with binding-competent OPRM1 isoforms and reduce their ligand binding activity. {ECO:0000269|PubMed:16580639}. |
| P38405 | GNAL | S56 | ochoa | Guanine nucleotide-binding protein G(olf) subunit alpha (EC 3.6.5.-) (Adenylate cyclase-stimulating G alpha protein, olfactory type) | Guanine nucleotide-binding protein (G protein) involved as transducer in olfactory signal transduction controlled by G protein-coupled receptors (GPCRs) (By similarity). Contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (By similarity). Signaling by an activated GPCR promotes GDP release and GTP binding (By similarity). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (By similarity). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (By similarity). GNAL/G(olf) alpha specifically mediates olfactory signal transduction within the olfactory neuroepithelium and the basal ganglia following GPCRs activation (By similarity). Acts by promoting the specific activation of adenylyl cyclase ADCY3, resulting in increased levels of the signaling molecule cAMP (By similarity). {ECO:0000250|UniProtKB:P38406, ECO:0000250|UniProtKB:Q8CGK7}. |
| P40222 | TXLNA | S489 | ochoa | Alpha-taxilin | May be involved in intracellular vesicle traffic and potentially in calcium-dependent exocytosis in neuroendocrine cells. |
| P42574 | CASP3 | S176 | ochoa | Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] | Thiol protease that acts as a major effector caspase involved in the execution phase of apoptosis (PubMed:18723680, PubMed:20566630, PubMed:23650375, PubMed:35338844, PubMed:35446120, PubMed:7596430). Following cleavage and activation by initiator caspases (CASP8, CASP9 and/or CASP10), mediates execution of apoptosis by catalyzing cleavage of many proteins (PubMed:18723680, PubMed:20566630, PubMed:23650375, PubMed:7596430). At the onset of apoptosis, it proteolytically cleaves poly(ADP-ribose) polymerase PARP1 at a '216-Asp-|-Gly-217' bond (PubMed:10497198, PubMed:16374543, PubMed:7596430, PubMed:7774019). Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain (By similarity). Cleaves and activates caspase-6, -7 and -9 (CASP6, CASP7 and CASP9, respectively) (PubMed:7596430). Cleaves and inactivates interleukin-18 (IL18) (PubMed:37993714, PubMed:9334240). Involved in the cleavage of huntingtin (PubMed:8696339). Triggers cell adhesion in sympathetic neurons through RET cleavage (PubMed:21357690). Cleaves and inhibits serine/threonine-protein kinase AKT1 in response to oxidative stress (PubMed:23152800). Acts as an inhibitor of type I interferon production during virus-induced apoptosis by mediating cleavage of antiviral proteins CGAS, IRF3 and MAVS, thereby preventing cytokine overproduction (PubMed:30878284). Also involved in pyroptosis by mediating cleavage and activation of gasdermin-E (GSDME) (PubMed:35338844, PubMed:35446120). Cleaves XRCC4 and phospholipid scramblase proteins XKR4, XKR8 and XKR9, leading to promote phosphatidylserine exposure on apoptotic cell surface (PubMed:23845944, PubMed:33725486). Cleaves BIRC6 following inhibition of BIRC6-caspase binding by DIABLO/SMAC (PubMed:36758104, PubMed:36758106). {ECO:0000250|UniProtKB:Q60431, ECO:0000269|PubMed:10497198, ECO:0000269|PubMed:16374543, ECO:0000269|PubMed:18723680, ECO:0000269|PubMed:20566630, ECO:0000269|PubMed:21357690, ECO:0000269|PubMed:23152800, ECO:0000269|PubMed:23650375, ECO:0000269|PubMed:23845944, ECO:0000269|PubMed:30878284, ECO:0000269|PubMed:33725486, ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120, ECO:0000269|PubMed:36758104, ECO:0000269|PubMed:36758106, ECO:0000269|PubMed:37993714, ECO:0000269|PubMed:7596430, ECO:0000269|PubMed:7774019, ECO:0000269|PubMed:8696339, ECO:0000269|PubMed:9334240}. |
| P43243 | MATR3 | S208 | ochoa|psp | Matrin-3 | May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32245947}. |
| P46976 | GYG1 | S46 | ochoa | Glycogenin-1 (GN-1) (GN1) (EC 2.4.1.186) | Glycogenin participates in the glycogen biosynthetic process along with glycogen synthase and glycogen branching enzyme. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase. {ECO:0000269|PubMed:22160680, ECO:0000269|PubMed:30356213}. |
| P47897 | QARS1 | S495 | ochoa | Glutamine--tRNA ligase (EC 6.1.1.18) (Glutaminyl-tRNA synthetase) (GlnRS) | Glutamine--tRNA ligase (PubMed:26869582). Plays a critical role in brain development (PubMed:24656866). {ECO:0000269|PubMed:24656866, ECO:0000269|PubMed:26869582}. |
| P48634 | PRRC2A | S305 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P49023 | PXN | S274 | psp | Paxillin | Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion. {ECO:0000269|PubMed:25015296}. |
| P49748 | ACADVL | S590 | ochoa | Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (VLCAD) (EC 1.3.8.9) | Very long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats (PubMed:18227065, PubMed:7668252, PubMed:9461620, PubMed:9599005, PubMed:9839948). The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (PubMed:18227065, PubMed:7668252, PubMed:9461620, PubMed:9839948). Among the different mitochondrial acyl-CoA dehydrogenases, very long-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 12 to 24 carbons long primary chains (PubMed:21237683, PubMed:9839948). {ECO:0000269|PubMed:18227065, ECO:0000269|PubMed:21237683, ECO:0000269|PubMed:7668252, ECO:0000269|PubMed:9461620, ECO:0000269|PubMed:9599005, ECO:0000269|PubMed:9839948}. |
| P49790 | NUP153 | S247 | ochoa | Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}. |
| P50148 | GNAQ | S53 | psp | Guanine nucleotide-binding protein G(q) subunit alpha (EC 3.6.5.-) (Guanine nucleotide-binding protein alpha-q) | Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades (PubMed:37991948). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (PubMed:37991948). Signaling by an activated GPCR promotes GDP release and GTP binding (PubMed:37991948). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (PubMed:37991948). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:37991948). Signaling is mediated via phospholipase C-beta-dependent inositol lipid hydrolysis for signal propagation: activates phospholipase C-beta: following GPCR activation, GNAQ activates PLC-beta (PLCB1, PLCB2, PLCB3 or PLCB4), leading to production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (PubMed:37991948). Required for platelet activation (By similarity). Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity (By similarity). Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity). Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs) (PubMed:27852822). Together with GNA11, required for heart development (By similarity). {ECO:0000250|UniProtKB:P21279, ECO:0000269|PubMed:27852822, ECO:0000269|PubMed:37991948}. |
| P51787 | KCNQ1 | S95 | psp | Potassium voltage-gated channel subfamily KQT member 1 (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1) (Voltage-gated potassium channel subunit Kv7.1) | Pore-forming subunit of the voltage-gated potassium (Kv) channel involved in the regulation of cardiomyocyte excitability and important in normal development and functions of myocardium, inner ear, stomach and colon (PubMed:10646604, PubMed:25441029). Associates with KCNE beta subunits that modulates current kinetics (PubMed:10646604, PubMed:11101505, PubMed:19687231, PubMed:8900283, PubMed:9108097, PubMed:9312006). Induces a voltage-dependent current by rapidly activating and slowly deactivating potassium-selective outward current (PubMed:10646604, PubMed:11101505, PubMed:25441029, PubMed:8900283, PubMed:9108097, PubMed:9312006). Also promotes a delayed voltage activated potassium current showing outward rectification characteristic (By similarity). During beta-adrenergic receptor stimulation, participates in cardiac repolarization by associating with KCNE1 to form the I(Ks) cardiac potassium current that increases the amplitude and slows down the activation kinetics of outward potassium current I(Ks) (By similarity) (PubMed:10646604, PubMed:11101505, PubMed:8900283, PubMed:9108097, PubMed:9312006). Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current (PubMed:10713961). When associated with KCNE3, forms the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions (PubMed:10646604). This interaction with KCNE3 is reduced by 17beta-estradiol, resulting in the reduction of currents (By similarity). During conditions of increased substrate load, maintains the driving force for proximal tubular and intestinal sodium ions absorption, gastric acid secretion, and cAMP-induced jejunal chloride ions secretion (By similarity). Allows the provision of potassium ions to the luminal membrane of the secretory canaliculus in the resting state as well as during stimulated acid secretion (By similarity). When associated with KCNE2, forms a heterooligomer complex leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (PubMed:11101505). When associated with KCNE4, inhibits voltage-gated potassium channel activity (PubMed:19687231). When associated with KCNE5, this complex only conducts current upon strong and continued depolarization (PubMed:12324418). Also forms a heterotetramer with KCNQ5; has a voltage-gated potassium channel activity (PubMed:24855057). Binds with phosphatidylinositol 4,5-bisphosphate (PubMed:25037568). KCNQ1-KCNE2 channel associates with Na(+)-coupled myo-inositol symporter in the apical membrane of choroid plexus epithelium and regulates the myo-inositol gradient between blood and cerebrospinal fluid with an impact on neuron excitability (By similarity). {ECO:0000250|UniProtKB:P97414, ECO:0000250|UniProtKB:Q9Z0N7, ECO:0000269|PubMed:10646604, ECO:0000269|PubMed:10713961, ECO:0000269|PubMed:11101505, ECO:0000269|PubMed:12324418, ECO:0000269|PubMed:19687231, ECO:0000269|PubMed:24595108, ECO:0000269|PubMed:24855057, ECO:0000269|PubMed:25037568, ECO:0000269|PubMed:8900283, ECO:0000269|PubMed:9108097, ECO:0000269|PubMed:9312006}.; FUNCTION: [Isoform 2]: Non-functional alone but modulatory when coexpressed with the full-length isoform 1. {ECO:0000269|PubMed:9305853}. |
| P51798 | CLCN7 | S61 | ochoa | H(+)/Cl(-) exchange transporter 7 (Chloride channel 7 alpha subunit) (Chloride channel protein 7) (ClC-7) | Slowly voltage-gated channel mediating the exchange of chloride ions against protons (PubMed:18449189, PubMed:21527911). Functions as antiporter and contributes to the acidification of the lysosome lumen and may be involved in maintaining lysosomal pH (PubMed:18449189, PubMed:21527911, PubMed:31155284). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (By similarity). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity). {ECO:0000250|UniProtKB:P35523, ECO:0000269|PubMed:18449189, ECO:0000269|PubMed:21527911, ECO:0000269|PubMed:31155284}. |
| P61981 | YWHAG | S219 | ochoa | 14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed] | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binding generally results in the modulation of the activity of the binding partner (PubMed:16511572). Promotes inactivation of WDR24 component of the GATOR2 complex by binding to phosphorylated WDR24 (PubMed:36732624). Participates in the positive regulation of NMDA glutamate receptor activity by promoting the L-glutamate secretion through interaction with BEST1 (PubMed:29121962). Reduces keratinocyte intercellular adhesion, via interacting with PKP1 and sequestering it in the cytoplasm, thereby reducing its incorporation into desmosomes (PubMed:29678907). Plays a role in mitochondrial protein catabolic process (also named MALM) that promotes the degradation of damaged proteins inside mitochondria (PubMed:22532927). {ECO:0000269|PubMed:15696159, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:22532927, ECO:0000269|PubMed:29121962, ECO:0000269|PubMed:29678907, ECO:0000269|PubMed:36732624}. |
| P62258 | YWHAE | S217 | ochoa | 14-3-3 protein epsilon (14-3-3E) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:21189250). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35343654). Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326). Plays a positive role in the antiviral signaling pathway upstream of TBK1 via interaction with RIGI (PubMed:37555661). Mechanistically, directs RIGI redistribution from the cytosol to mitochondrial associated membranes where it mediates MAVS-dependent innate immune signaling during viral infection (PubMed:22607805). Plays a role in proliferation inhibition and cell cycle arrest by exporting HNRNPC from the nucleus to the cytoplasm to be degraded by ubiquitination (PubMed:37599448). {ECO:0000250|UniProtKB:P62261, ECO:0000269|PubMed:12917326, ECO:0000269|PubMed:21189250, ECO:0000269|PubMed:22607805, ECO:0000269|PubMed:35343654, ECO:0000269|PubMed:37555661, ECO:0000269|PubMed:37599448}. |
| P62318 | SNRPD3 | S66 | ochoa | Small nuclear ribonucleoprotein Sm D3 (Sm-D3) (snRNP core protein D3) | Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:25555158, PubMed:26912367, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:32494006). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28076346, PubMed:28502770, PubMed:28781166). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing (By similarity). {ECO:0000250|UniProtKB:P62320, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:19325628, ECO:0000269|PubMed:25555158, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932}. |
| P63096 | GNAI1 | S47 | ochoa | Guanine nucleotide-binding protein G(i) subunit alpha-1 (EC 3.6.5.-) (Adenylate cyclase-inhibiting G alpha protein) | Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades (PubMed:18434541, PubMed:33762731, PubMed:34239069, PubMed:35610220, PubMed:37935376, PubMed:37935377, PubMed:37963465, PubMed:38552625, PubMed:8774883, PubMed:38918398). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (PubMed:18434541, PubMed:8774883). Signaling by an activated GPCR promotes GDP release and GTP binding (PubMed:18434541, PubMed:8774883). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (PubMed:18434541, PubMed:8774883). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:18434541, PubMed:8774883). Signaling is mediated via effector proteins, such as adenylate cyclase: inhibits adenylate cyclase activity of ADCY1, ADCY5 and ADCY6, leading to decreased intracellular cAMP levels (PubMed:8119955). The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. Required for normal cytokinesis during mitosis (PubMed:17635935). Required for cortical dynein-dynactin complex recruitment during metaphase (PubMed:22327364). {ECO:0000250|UniProtKB:P10824, ECO:0000269|PubMed:17635935, ECO:0000269|PubMed:18434541, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:33762731, ECO:0000269|PubMed:34239069, ECO:0000269|PubMed:35610220, ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37935377, ECO:0000269|PubMed:37963465, ECO:0000269|PubMed:38552625, ECO:0000269|PubMed:38918398, ECO:0000269|PubMed:8119955, ECO:0000269|PubMed:8774883}. |
| P63104 | YWHAZ | S214 | ochoa | 14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:14578935, PubMed:15071501, PubMed:15644438, PubMed:16376338, PubMed:16959763, PubMed:31024343, PubMed:9360956). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35662396). Binding generally results in the modulation of the activity of the binding partner (PubMed:35662396). Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB (PubMed:35662396). Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity). {ECO:0000250|UniProtKB:O55043, ECO:0000269|PubMed:14578935, ECO:0000269|PubMed:15071501, ECO:0000269|PubMed:15644438, ECO:0000269|PubMed:16376338, ECO:0000269|PubMed:16959763, ECO:0000269|PubMed:31024343, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:9360956}. |
| P68871 | HBB | S90 | ochoa | Hemoglobin subunit beta (Beta-globin) (Hemoglobin beta chain) [Cleaved into: LVV-hemorphin-7; Spinorphin] | Involved in oxygen transport from the lung to the various peripheral tissues. {ECO:0000269|PubMed:28066926}.; FUNCTION: LVV-hemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure.; FUNCTION: [Spinorphin]: Functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation. |
| P98155 | VLDLR | S846 | ochoa | Very low-density lipoprotein receptor (VLDL receptor) (VLDL-R) | Multifunctional cell surface receptor that binds VLDL and transports it into cells by endocytosis and therefore plays an important role in energy metabolism. Also binds to a wide range of other molecules including Reelin/RELN or apolipoprotein E/APOE-containing ligands as well as clusterin/CLU (PubMed:24381170, PubMed:30873003). In the off-state of the pathway, forms homooligomers or heterooligomers with LRP8 (PubMed:30873003). Upon binding to ligands, homooligomers are rearranged to higher order receptor clusters that transmit the extracellular RELN signal to intracellular signaling processes by binding to DAB1 (PubMed:30873003). This interaction results in phosphorylation of DAB1 leading to the ultimate cell responses required for the correct positioning of newly generated neurons. Later, mediates a stop signal for migrating neurons, preventing them from entering the marginal zone (By similarity). {ECO:0000250|UniProtKB:P98156, ECO:0000269|PubMed:24381170, ECO:0000269|PubMed:30873003}.; FUNCTION: (Microbial infection) Acts as a receptor for Semliki Forest virus. {ECO:0000269|PubMed:34929721}. |
| P98160 | HSPG2 | S2691 | ochoa | Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG) (Perlecan) (PLC) [Cleaved into: Endorepellin; LG3 peptide] | Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development.; FUNCTION: [Endorepellin]: Anti-angiogenic and anti-tumor peptide that inhibits endothelial cell migration, collagen-induced endothelial tube morphogenesis and blood vessel growth in the chorioallantoic membrane. Blocks endothelial cell adhesion to fibronectin and type I collagen. Anti-tumor agent in neovascularization. Interaction with its ligand, integrin alpha2/beta1, is required for the anti-angiogenic properties. Evokes a reduction in phosphorylation of receptor tyrosine kinases via alpha2/beta1 integrin-mediated activation of the tyrosine phosphatase, PTPN6.; FUNCTION: [LG3 peptide]: Has anti-angiogenic properties that require binding of calcium ions for full activity. |
| Q00266 | MAT1A | S180 | psp | S-adenosylmethionine synthase isoform type-1 (AdoMet synthase 1) (EC 2.5.1.6) (Methionine adenosyltransferase 1) (MAT 1) (Methionine adenosyltransferase I/III) (MAT-I/III) | Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate. {ECO:0000269|PubMed:10677294}. |
| Q00587 | CDC42EP1 | S26 | ochoa | Cdc42 effector protein 1 (Binder of Rho GTPases 5) (Serum protein MSE55) | Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts. {ECO:0000269|PubMed:10430899}. |
| Q00613 | HSF1 | S333 | ochoa|psp | Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1) | Functions as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones, heat shock proteins (HSPs), that protect cells from cellular insult damage (PubMed:11447121, PubMed:12659875, PubMed:12917326, PubMed:15016915, PubMed:18451878, PubMed:1871105, PubMed:1986252, PubMed:25963659, PubMed:26754925, PubMed:7623826, PubMed:7760831, PubMed:8940068, PubMed:8946918, PubMed:9121459, PubMed:9341107, PubMed:9499401, PubMed:9535852, PubMed:9727490). In unstressed cells, is present in a HSP90-containing multichaperone complex that maintains it in a non-DNA-binding inactivated monomeric form (PubMed:11583998, PubMed:16278218, PubMed:9727490). Upon exposure to heat and other stress stimuli, undergoes homotrimerization and activates HSP gene transcription through binding to site-specific heat shock elements (HSEs) present in the promoter regions of HSP genes (PubMed:10359787, PubMed:11583998, PubMed:12659875, PubMed:16278218, PubMed:1871105, PubMed:1986252, PubMed:25963659, PubMed:26754925, PubMed:7623826, PubMed:7935471, PubMed:8455624, PubMed:8940068, PubMed:9499401, PubMed:9727490). Upon heat shock stress, forms a chromatin-associated complex with TTC5/STRAP and p300/EP300 to stimulate HSR transcription, therefore increasing cell survival (PubMed:18451878). Activation is reversible, and during the attenuation and recovery phase period of the HSR, returns to its unactivated form (PubMed:11583998, PubMed:16278218). Binds to inverted 5'-NGAAN-3' pentamer DNA sequences (PubMed:1986252, PubMed:26727489). Binds to chromatin at heat shock gene promoters (PubMed:25963659). Activates transcription of transcription factor FOXR1 which in turn activates transcription of the heat shock chaperones HSPA1A and HSPA6 and the antioxidant NADPH-dependent reductase DHRS2 (PubMed:34723967). Also serves several other functions independently of its transcriptional activity. Involved in the repression of Ras-induced transcriptional activation of the c-fos gene in heat-stressed cells (PubMed:9341107). Positively regulates pre-mRNA 3'-end processing and polyadenylation of HSP70 mRNA upon heat-stressed cells in a symplekin (SYMPK)-dependent manner (PubMed:14707147). Plays a role in nuclear export of stress-induced HSP70 mRNA (PubMed:17897941). Plays a role in the regulation of mitotic progression (PubMed:18794143). Also plays a role as a negative regulator of non-homologous end joining (NHEJ) repair activity in a DNA damage-dependent manner (PubMed:26359349). Involved in stress-induced cancer cell proliferation in a IER5-dependent manner (PubMed:26754925). {ECO:0000269|PubMed:10359787, ECO:0000269|PubMed:11447121, ECO:0000269|PubMed:11583998, ECO:0000269|PubMed:12659875, ECO:0000269|PubMed:12917326, ECO:0000269|PubMed:14707147, ECO:0000269|PubMed:15016915, ECO:0000269|PubMed:16278218, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18451878, ECO:0000269|PubMed:1871105, ECO:0000269|PubMed:18794143, ECO:0000269|PubMed:1986252, ECO:0000269|PubMed:25963659, ECO:0000269|PubMed:26359349, ECO:0000269|PubMed:26727489, ECO:0000269|PubMed:26754925, ECO:0000269|PubMed:34723967, ECO:0000269|PubMed:7623826, ECO:0000269|PubMed:7760831, ECO:0000269|PubMed:7935471, ECO:0000269|PubMed:8455624, ECO:0000269|PubMed:8940068, ECO:0000269|PubMed:8946918, ECO:0000269|PubMed:9121459, ECO:0000269|PubMed:9341107, ECO:0000269|PubMed:9499401, ECO:0000269|PubMed:9535852, ECO:0000269|PubMed:9727490}.; FUNCTION: (Microbial infection) Plays a role in latent human immunodeficiency virus (HIV-1) transcriptional reactivation. Binds to the HIV-1 long terminal repeat promoter (LTR) to reactivate viral transcription by recruiting cellular transcriptional elongation factors, such as CDK9, CCNT1 and EP300. {ECO:0000269|PubMed:27189267}. |
| Q00765 | REEP5 | S154 | ochoa | Receptor expression-enhancing protein 5 (Polyposis locus protein 1) (Protein TB2) | Plays an essential role in heart function and development by regulating the organization and function of the sarcoplasmic reticulum in cardiomyocytes. {ECO:0000250|UniProtKB:Q60870}. |
| Q01814 | ATP2B2 | S1163 | ochoa | Plasma membrane calcium-transporting ATPase 2 (PMCA2) (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 2) (Plasma membrane calcium pump isoform 2) | ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels in specialized cells of cerebellar circuit and vestibular and cochlear systems (PubMed:15829536, PubMed:17234811). Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment (PubMed:15829536, PubMed:17234811). Has fast activation and Ca(2+) clearance rate suited to control fast neuronal Ca(2+) dynamics. At parallel fiber to Purkinje neuron synapse, mediates presynaptic Ca(2+) efflux in response to climbing fiber-induced Ca(2+) rise. Provides for fast return of Ca(2+) concentrations back to their resting levels, ultimately contributing to long-term depression induction and motor learning (By similarity). Plays an essential role in hearing and balance (PubMed:15829536, PubMed:17234811). In cochlear hair cells, shuttles Ca(2+) ions from stereocilia to the endolymph and dissipates Ca(2+) transients generated by the opening of the mechanoelectrical transduction channels. Regulates Ca(2+) levels in the vestibular system, where it contributes to the formation of otoconia (PubMed:15829536, PubMed:17234811). In non-excitable cells, regulates Ca(2+) signaling through spatial control of Ca(2+) ions extrusion and dissipation of Ca(2+) transients generated by store-operated channels (PubMed:25690014). In lactating mammary gland, allows for the high content of Ca(2+) ions in the milk (By similarity). {ECO:0000250|UniProtKB:Q9R0K7, ECO:0000269|PubMed:15829536, ECO:0000269|PubMed:17234811, ECO:0000269|PubMed:25690014}. |
| Q02880 | TOP2B | S1424 | ochoa | DNA topoisomerase 2-beta (EC 5.6.2.2) (DNA topoisomerase II, beta isozyme) | Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Plays a role in B-cell differentiation. {ECO:0000269|PubMed:10684600, ECO:0000269|PubMed:31409799, ECO:0000269|PubMed:32128574}. |
| Q04917 | YWHAH | S219 | ochoa | 14-3-3 protein eta (Protein AS1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. {ECO:0000269|PubMed:12177059}. |
| Q08050 | FOXM1 | S730 | ochoa|psp | Forkhead box protein M1 (Forkhead-related protein FKHL16) (Hepatocyte nuclear factor 3 forkhead homolog 11) (HFH-11) (HNF-3/fork-head homolog 11) (M-phase phosphoprotein 2) (MPM-2 reactive phosphoprotein 2) (Transcription factor Trident) (Winged-helix factor from INS-1 cells) | Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis (PubMed:19160488, PubMed:20360045). Plays a role in the control of cell proliferation (PubMed:19160488). Also plays a role in DNA break repair, participating in the DNA damage checkpoint response (PubMed:17101782). Promotes transcription of PHB2 (PubMed:33754036). {ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:19160488, ECO:0000269|PubMed:20360045, ECO:0000269|PubMed:33754036}. |
| Q08211 | DHX9 | S77 | ochoa | ATP-dependent RNA helicase A (EC 3.6.4.13) (DEAH box protein 9) (DExH-box helicase 9) (Leukophysin) (LKP) (Nuclear DNA helicase II) (NDH II) (RNA helicase A) | Multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and that plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation and RNA-mediated gene silencing (PubMed:11416126, PubMed:12711669, PubMed:15355351, PubMed:16680162, PubMed:17531811, PubMed:20669935, PubMed:21561811, PubMed:24049074, PubMed:24990949, PubMed:25062910, PubMed:28221134, PubMed:9111062, PubMed:37467750). Requires a 3'-single-stranded tail as entry site for acid nuclei unwinding activities as well as the binding and hydrolyzing of any of the four ribo- or deoxyribo-nucleotide triphosphates (NTPs) (PubMed:1537828). Unwinds numerous nucleic acid substrates such as double-stranded (ds) DNA and RNA, DNA:RNA hybrids, DNA and RNA forks composed of either partially complementary DNA duplexes or DNA:RNA hybrids, respectively, and also DNA and RNA displacement loops (D- and R-loops), triplex-helical DNA (H-DNA) structure and DNA and RNA-based G-quadruplexes (PubMed:20669935, PubMed:21561811, PubMed:24049074). Binds dsDNA, single-stranded DNA (ssDNA), dsRNA, ssRNA and poly(A)-containing RNA (PubMed:10198287, PubMed:9111062). Also binds to circular dsDNA or dsRNA of either linear and/or circular forms and stimulates the relaxation of supercoiled DNAs catalyzed by topoisomerase TOP2A (PubMed:12711669). Plays a role in DNA replication at origins of replication and cell cycle progression (PubMed:24990949). Plays a role as a transcriptional coactivator acting as a bridging factor between polymerase II holoenzyme and transcription factors or cofactors, such as BRCA1, CREBBP, RELA and SMN1 (PubMed:11038348, PubMed:11149922, PubMed:11416126, PubMed:15355351, PubMed:28221134, PubMed:9323138, PubMed:9662397). Binds to the CDKN2A promoter (PubMed:11038348). Plays several roles in post-transcriptional regulation of gene expression (PubMed:28221134, PubMed:28355180). In cooperation with NUP98, promotes pre-mRNA alternative splicing activities of a subset of genes (PubMed:11402034, PubMed:16680162, PubMed:28221134, PubMed:28355180). As component of a large PER complex, is involved in the negative regulation of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms (By similarity). Also acts as a nuclear resolvase that is able to bind and neutralize harmful massive secondary double-stranded RNA structures formed by inverted-repeat Alu retrotransposon elements that are inserted and transcribed as parts of genes during the process of gene transposition (PubMed:28355180). Involved in the positive regulation of nuclear export of constitutive transport element (CTE)-containing unspliced mRNA (PubMed:10924507, PubMed:11402034, PubMed:9162007). Component of the coding region determinant (CRD)-mediated complex that promotes cytoplasmic MYC mRNA stability (PubMed:19029303). Plays a role in mRNA translation (PubMed:28355180). Positively regulates translation of selected mRNAs through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162). Involved with LARP6 in the translation stimulation of type I collagen mRNAs for CO1A1 and CO1A2 through binding of a specific stem-loop structure in their 5'-UTRs (PubMed:22190748). Stimulates LIN28A-dependent mRNA translation probably by facilitating ribonucleoprotein remodeling during the process of translation (PubMed:21247876). Plays also a role as a small interfering (siRNA)-loading factor involved in the RNA-induced silencing complex (RISC) loading complex (RLC) assembly, and hence functions in the RISC-mediated gene silencing process (PubMed:17531811). Binds preferentially to short double-stranded RNA, such as those produced during rotavirus intestinal infection (PubMed:28636595). This interaction may mediate NLRP9 inflammasome activation and trigger inflammatory response, including IL18 release and pyroptosis (PubMed:28636595). Finally, mediates the attachment of heterogeneous nuclear ribonucleoproteins (hnRNPs) to actin filaments in the nucleus (PubMed:11687588). {ECO:0000250|UniProtKB:O70133, ECO:0000269|PubMed:10198287, ECO:0000269|PubMed:10924507, ECO:0000269|PubMed:11038348, ECO:0000269|PubMed:11149922, ECO:0000269|PubMed:11402034, ECO:0000269|PubMed:11416126, ECO:0000269|PubMed:11687588, ECO:0000269|PubMed:12711669, ECO:0000269|PubMed:15355351, ECO:0000269|PubMed:1537828, ECO:0000269|PubMed:16680162, ECO:0000269|PubMed:17531811, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:20669935, ECO:0000269|PubMed:21247876, ECO:0000269|PubMed:21561811, ECO:0000269|PubMed:22190748, ECO:0000269|PubMed:24049074, ECO:0000269|PubMed:24990949, ECO:0000269|PubMed:25062910, ECO:0000269|PubMed:28221134, ECO:0000269|PubMed:28355180, ECO:0000269|PubMed:28636595, ECO:0000269|PubMed:37467750, ECO:0000269|PubMed:9111062, ECO:0000269|PubMed:9162007, ECO:0000269|PubMed:9323138, ECO:0000269|PubMed:9662397}.; FUNCTION: (Microbial infection) Plays a role in HIV-1 replication and virion infectivity (PubMed:11096080, PubMed:19229320, PubMed:25149208, PubMed:27107641). Enhances HIV-1 transcription by facilitating the binding of RNA polymerase II holoenzyme to the proviral DNA (PubMed:11096080, PubMed:25149208). Binds (via DRBM domain 2) to the HIV-1 TAR RNA and stimulates HIV-1 transcription of transactivation response element (TAR)-containing mRNAs (PubMed:11096080, PubMed:9892698). Involved also in HIV-1 mRNA splicing and transport (PubMed:25149208). Positively regulates HIV-1 gag mRNA translation, through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162). Binds (via DRBM domains) to a HIV-1 double-stranded RNA region of the primer binding site (PBS)-segment of the 5'-UTR, and hence stimulates DHX9 incorporation into virions and virion infectivity (PubMed:27107641). Also plays a role as a cytosolic viral MyD88-dependent DNA and RNA sensors in plasmacytoid dendritic cells (pDCs), and hence induce antiviral innate immune responses (PubMed:20696886, PubMed:21957149). Binds (via the OB-fold region) to viral single-stranded DNA unmethylated C-phosphate-G (CpG) oligonucleotide (PubMed:20696886). {ECO:0000269|PubMed:11096080, ECO:0000269|PubMed:16680162, ECO:0000269|PubMed:19229320, ECO:0000269|PubMed:20696886, ECO:0000269|PubMed:21957149, ECO:0000269|PubMed:25149208, ECO:0000269|PubMed:27107641, ECO:0000269|PubMed:9892698}. |
| Q12778 | FOXO1 | S470 | ochoa | Forkhead box protein O1 (Forkhead box protein O1A) (Forkhead in rhabdomyosarcoma) | Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress (PubMed:10358076, PubMed:12228231, PubMed:15220471, PubMed:15890677, PubMed:18356527, PubMed:19221179, PubMed:20543840, PubMed:21245099). Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3' (PubMed:10358076). Activity suppressed by insulin (PubMed:10358076). Main regulator of redox balance and osteoblast numbers and controls bone mass (By similarity). Orchestrates the endocrine function of the skeleton in regulating glucose metabolism (By similarity). Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity (By similarity). Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP (By similarity). Acts as an inhibitor of glucose sensing in pancreatic beta cells by acting as a transcription repressor and suppressing expression of PDX1 (By similarity). In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC1 and PCK1 (By similarity). Also promotes gluconeogenesis by directly promoting expression of PPARGC1A and G6PC1 (PubMed:17024043). Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and STK4/MST1 (PubMed:18356527, PubMed:19221179). Promotes neural cell death (PubMed:18356527). Mediates insulin action on adipose tissue (By similarity). Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake (By similarity). Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells (By similarity). Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner (PubMed:20543840). Mediates the function of MLIP in cardiomyocytes hypertrophy and cardiac remodeling (By similarity). Positive regulator of apoptosis in cardiac smooth muscle cells as a result of its transcriptional activation of pro-apoptotic genes (PubMed:19483080). Regulates endothelial cell (EC) viability and apoptosis in a PPIA/CYPA-dependent manner via transcription of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (PubMed:31063815). {ECO:0000250|UniProtKB:A4L7N3, ECO:0000250|UniProtKB:G3V7R4, ECO:0000250|UniProtKB:Q9R1E0, ECO:0000269|PubMed:10358076, ECO:0000269|PubMed:12228231, ECO:0000269|PubMed:15220471, ECO:0000269|PubMed:15890677, ECO:0000269|PubMed:17024043, ECO:0000269|PubMed:18356527, ECO:0000269|PubMed:19221179, ECO:0000269|PubMed:19483080, ECO:0000269|PubMed:20543840, ECO:0000269|PubMed:21245099, ECO:0000269|PubMed:31063815}. |
| Q12931 | TRAP1 | S195 | ochoa | Heat shock protein 75 kDa, mitochondrial (HSP 75) (Heat shock protein family C member 5) (TNFR-associated protein 1) (Tumor necrosis factor type 1 receptor-associated protein) (TRAP-1) | Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA. {ECO:0000269|PubMed:23525905, ECO:0000269|PubMed:23564345, ECO:0000269|PubMed:23747254}. |
| Q12959 | DLG1 | S598 | ochoa | Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (SAP97) (hDlg) | Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). May also play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel. During long-term depression in hippocampal neurons, it recruits ADAM10 to the plasma membrane (PubMed:23676497). {ECO:0000250|UniProtKB:A0A8C0TYJ0, ECO:0000250|UniProtKB:Q811D0, ECO:0000269|PubMed:10656683, ECO:0000269|PubMed:12445884, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15263016, ECO:0000269|PubMed:19213956, ECO:0000269|PubMed:20605917, ECO:0000269|PubMed:23676497}. |
| Q12981 | BNIP1 | S179 | ochoa | Vesicle transport protein SEC20 (BCL2/adenovirus E1B 19 kDa protein-interacting protein 1) (Transformation-related gene 8 protein) (TRG-8) | As part of a SNARE complex may be involved in endoplasmic reticulum membranes fusion and be required for the maintenance of endoplasmic reticulum organization (PubMed:15272311). Also plays a role in apoptosis (PubMed:15272311, PubMed:23896122, PubMed:7954800). It is for instance required for endoplasmic reticulum stress-induced apoptosis (PubMed:23896122). As a substrate of RNF185 interacting with SQSTM1, might also be involved in mitochondrial autophagy (Probable). {ECO:0000269|PubMed:15272311, ECO:0000269|PubMed:23896122, ECO:0000269|PubMed:7954800, ECO:0000305|PubMed:21931693}. |
| Q13177 | PAK2 | S132 | ochoa | Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (Gamma-PAK) (PAK65) (S6/H4 kinase) (p21-activated kinase 2) (PAK-2) (p58) [Cleaved into: PAK-2p27 (p27); PAK-2p34 (p34) (C-t-PAK2)] | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation (PubMed:12853446, PubMed:16617111, PubMed:19273597, PubMed:19923322, PubMed:33693784, PubMed:7744004, PubMed:9171063). Acts as a downstream effector of the small GTPases CDC42 and RAC1 (PubMed:7744004). Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues (PubMed:7744004). Full-length PAK2 stimulates cell survival and cell growth (PubMed:7744004). Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration (PubMed:21317288). Phosphorylates JUN and plays an important role in EGF-induced cell proliferation (PubMed:21177766). Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP (PubMed:21724829). Phosphorylates CASP7, thereby preventing its activity (PubMed:21555521, PubMed:27889207). Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis (PubMed:19273597, PubMed:19923322). On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway (PubMed:12853446, PubMed:16617111, PubMed:9171063). Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation (PubMed:15234964). {ECO:0000269|PubMed:12853446, ECO:0000269|PubMed:15234964, ECO:0000269|PubMed:16617111, ECO:0000269|PubMed:19273597, ECO:0000269|PubMed:19923322, ECO:0000269|PubMed:21177766, ECO:0000269|PubMed:21317288, ECO:0000269|PubMed:21555521, ECO:0000269|PubMed:21724829, ECO:0000269|PubMed:27889207, ECO:0000269|PubMed:33693784, ECO:0000269|PubMed:7744004, ECO:0000269|PubMed:9171063}. |
| Q13190 | STX5 | S264 | ochoa | Syntaxin-5 | Mediates endoplasmic reticulum to Golgi transport. Together with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. {ECO:0000250|UniProtKB:Q08851}.; FUNCTION: [Isoform 2]: Required for Golgi to endoplasmic reticulum retrogade transport, and for intra-Golgi transport. {ECO:0000269|PubMed:34711829}.; FUNCTION: (Microbial infection) Required for the efficient production of infectious virion during human cytomegalovirus infection. Mechanistically, participates in the formation of the cytoplasmic viral assembly compartment where tegument acquisition and envelopment occur. {ECO:0000269|PubMed:27795424}. |
| Q13263 | TRIM28 | S501 | ochoa|psp | Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28) | Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also a corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:Q62318, ECO:0000269|PubMed:10347202, ECO:0000269|PubMed:11959841, ECO:0000269|PubMed:15882967, ECO:0000269|PubMed:16107876, ECO:0000269|PubMed:16862143, ECO:0000269|PubMed:17079232, ECO:0000269|PubMed:17178852, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17942393, ECO:0000269|PubMed:18060868, ECO:0000269|PubMed:18082607, ECO:0000269|PubMed:20424263, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:21940674, ECO:0000269|PubMed:23543754, ECO:0000269|PubMed:23665872, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:8769649, ECO:0000269|PubMed:9016654}.; FUNCTION: (Microbial infection) Plays a critical role in the shutdown of lytic gene expression during the early stage of herpes virus 8 primary infection. This inhibition is mediated through interaction with herpes virus 8 protein LANA1. {ECO:0000269|PubMed:24741090}. |
| Q13905 | RAPGEF1 | S375 | ochoa | Rap guanine nucleotide exchange factor 1 (CRK SH3-binding GNRP) (Guanine nucleotide-releasing factor 2) (Protein C3G) | Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1 (PubMed:12432078). Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth. {ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:7806500}. |
| Q14690 | PDCD11 | S438 | ochoa | Protein RRP5 homolog (NF-kappa-B-binding protein) (NFBP) (Programmed cell death protein 11) | Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA. {ECO:0000269|PubMed:17654514}.; FUNCTION: Involved in the biogenesis of rRNA. {ECO:0000250}. |
| Q15149 | PLEC | S919 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q15149 | PLEC | S1181 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q16706 | MAN2A1 | S943 | ochoa | Alpha-mannosidase 2 (EC 3.2.1.114) (Golgi alpha-mannosidase II) (AMan II) (Man II) (Mannosidase alpha class 2A member 1) (Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase) | Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway. {ECO:0000250|UniProtKB:P28494}. |
| Q1KMD3 | HNRNPUL2 | S543 | ochoa | Heterogeneous nuclear ribonucleoprotein U-like protein 2 (Scaffold-attachment factor A2) (SAF-A2) | None |
| Q2M1P5 | KIF7 | S452 | ochoa | Kinesin-like protein KIF7 | Essential for hedgehog signaling regulation: acts both as a negative and positive regulator of sonic hedgehog (Shh) and Indian hedgehog (Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and -independent mechanisms (PubMed:21633164). Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes (By similarity). Required for localization of GLI3 to cilia in response to Shh. Negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates Shh signaling by preventing the processing of the transcription factor GLI3 into its repressor form. In keratinocytes, promotes the dissociation of SUFU-GLI2 complexes, GLI2 nuclear translocation and Shh signaling activation (By similarity). Involved in the regulation of epidermal differentiation and chondrocyte development (By similarity). {ECO:0000250|UniProtKB:B7ZNG0, ECO:0000269|PubMed:21633164}. |
| Q4KWH8 | PLCH1 | S1492 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-eta-1) (Phospholipase C-eta-1) (PLC-eta-1) (Phospholipase C-like protein 3) (PLC-L3) | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by calcium-activated phosphatidylinositol-specific phospholipase C enzymes. {ECO:0000269|PubMed:15702972}. |
| Q5JWF2 | GNAS | S697 | ochoa | Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (EC 3.6.5.-) (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas) | Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins. Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. XLas isoforms interact with the same set of receptors as Gnas isoforms. {ECO:0000250|UniProtKB:Q6R0H7}. |
| Q5QJE6 | DNTTIP2 | S483 | ochoa | Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) | Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}. |
| Q5T5P2 | KIAA1217 | S526 | ochoa | Sickle tail protein homolog | Required for normal development of intervertebral disks. {ECO:0000250|UniProtKB:A2AQ25}. |
| Q68DQ2 | CRYBG3 | S2093 | ochoa | Very large A-kinase anchor protein (vlAKAP) (Beta/gamma crystallin domain-containing protein 3) | [Isoform vlAKAP]: Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA). {ECO:0000269|PubMed:25097019}. |
| Q6GYQ0 | RALGAPA1 | S832 | ochoa | Ral GTPase-activating protein subunit alpha-1 (GAP-related-interacting partner to E12) (GRIPE) (GTPase-activating Rap/Ran-GAP domain-like 1) (Tuberin-like protein 1) (p240) | Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. {ECO:0000250}. |
| Q6IBW4 | NCAPH2 | S127 | ochoa | Condensin-2 complex subunit H2 (Chromosome-associated protein H2) (hCAP-H2) (Kleisin-beta) (Non-SMC condensin II complex subunit H2) | Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of chromatin bridges at anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (By similarity). Seems to have lineage-specific role in T-cell development (PubMed:14532007). {ECO:0000250|UniProtKB:Q8BSP2, ECO:0000269|PubMed:14532007}. |
| Q6KC79 | NIPBL | S553 | ochoa|psp | Nipped-B-like protein (Delangin) (SCC2 homolog) | Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}. |
| Q6NZY4 | ZCCHC8 | S331 | ochoa | Zinc finger CCHC domain-containing protein 8 (TRAMP-like complex RNA-binding factor ZCCHC8) | Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex that is involved in the surveillance and turnover of aberrant transcripts and non-coding RNAs (PubMed:27871484). NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. May be involved in pre-mRNA splicing (Probable). It is required for 3'-end maturation of telomerase RNA component (TERC), TERC 3'-end targeting to the nuclear RNA exosome, and for telomerase function (PubMed:31488579). {ECO:0000269|PubMed:27871484, ECO:0000269|PubMed:31488579, ECO:0000305|PubMed:16263084}. |
| Q6P4E1 | GOLM2 | S332 | ochoa | Protein GOLM2 (Cancer susceptibility candidate gene 4 protein) (CASC4) (Golgi membrane protein 2) | None |
| Q6PIJ6 | FBXO38 | S592 | ochoa | F-box only protein 38 | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of PDCD1/PD-1, thereby regulating T-cells-mediated immunity (PubMed:30487606). Required for anti-tumor activity of T-cells by promoting the degradation of PDCD1/PD-1; the PDCD1-mediated inhibitory pathway being exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (PubMed:30487606). May indirectly stimulate the activity of transcription factor KLF7, a regulator of neuronal differentiation, without promoting KLF7 ubiquitination (By similarity). {ECO:0000250|UniProtKB:Q8BMI0, ECO:0000269|PubMed:30487606}. |
| Q6PJT7 | ZC3H14 | S240 | ochoa | Zinc finger CCCH domain-containing protein 14 (Mammalian suppressor of tau pathology-2) (MSUT-2) (Renal carcinoma antigen NY-REN-37) | RNA-binding protein involved in the biogenesis of circular RNAs (circRNAs), which are produced by back-splicing circularization of pre-mRNAs (PubMed:39461343). Acts by binding to both exon-intron boundary and 3'-UTR of pre-mRNAs to promote circRNA biogenesis through dimerization and the association with the spliceosome (PubMed:39461343). Required for spermatogenesis via involvement in circRNA biogenesis (PubMed:39461343). Regulates the pre-mRNA processing of ATP5MC1; preventing its degradation (PubMed:27563065). Also binds the poly(A) tail of mRNAs; controlling poly(A) length in neuronal cells (PubMed:17630287, PubMed:24671764). {ECO:0000269|PubMed:17630287, ECO:0000269|PubMed:24671764, ECO:0000269|PubMed:27563065, ECO:0000269|PubMed:39461343}. |
| Q71U36 | TUBA1A | S165 | psp | Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q7Z6Z7 | HUWE1 | S2600 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q7Z6Z7 | HUWE1 | S2632 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q86VS8 | HOOK3 | S693 | ochoa | Protein Hook homolog 3 (h-hook3) (hHK3) | Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Predominantly recruits 2 dyneins, which increases both the force and speed of the microtubule motor (PubMed:25035494, PubMed:33734450). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). {ECO:0000250|UniProtKB:Q8BUK6, ECO:0000269|PubMed:11238449, ECO:0000269|PubMed:17237231, ECO:0000269|PubMed:18799622, ECO:0000269|PubMed:25035494, ECO:0000269|PubMed:32073997, ECO:0000269|PubMed:33734450}.; FUNCTION: (Microbial infection) May serve as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking. {ECO:0000305}. |
| Q8IWB9 | TEX2 | S464 | ochoa | Testis-expressed protein 2 (Transmembrane protein 96) | During endoplasmic reticulum (ER) stress or when cellular ceramide levels increase, may induce contacts between the ER and medial-Golgi complex to facilitate non-vesicular transport of ceramides from the ER to the Golgi complex where they are converted to complex sphingolipids, preventing toxic ceramide accumulation. {ECO:0000269|PubMed:28011845}. |
| Q8IZT6 | ASPM | S267 | ochoa | Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog) | Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis. {ECO:0000269|PubMed:12355089, ECO:0000269|PubMed:15972725, ECO:0000269|PubMed:28436967}. |
| Q8N157 | AHI1 | S232 | ochoa | Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1) | Involved in vesicle trafficking and required for ciliogenesis, formation of primary non-motile cilium, and recruitment of RAB8A to the basal body of primary cilium. Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in neuronal differentiation. As a positive modulator of classical Wnt signaling, may play a crucial role in ciliary signaling during cerebellum embryonic development (PubMed:21623382). {ECO:0000250|UniProtKB:Q8K3E5, ECO:0000269|PubMed:21623382}. |
| Q8N1G4 | LRRC47 | S315 | ochoa | Leucine-rich repeat-containing protein 47 | None |
| Q8N350 | CBARP | S507 | ochoa | Voltage-dependent calcium channel beta subunit-associated regulatory protein | Negatively regulates voltage-gated calcium channels by preventing the interaction between their alpha and beta subunits. Thereby, negatively regulates calcium channels activity at the plasma membrane and indirectly inhibits calcium-regulated exocytosis. {ECO:0000250|UniProtKB:Q66L44}. |
| Q8N4T4 | ARHGEF39 | S110 | ochoa | Rho guanine nucleotide exchange factor 39 | Promotes cell proliferation. {ECO:0000269|PubMed:22327280}. |
| Q8N884 | CGAS | S201 | psp | Cyclic GMP-AMP synthase (cGAMP synthase) (cGAS) (h-cGAS) (EC 2.7.7.86) (2'3'-cGAMP synthase) (Mab-21 domain-containing protein 1) | Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (2',3'-cGAMP) from ATP and GTP and plays a key role in innate immunity (PubMed:21478870, PubMed:23258413, PubMed:23707061, PubMed:23707065, PubMed:23722159, PubMed:24077100, PubMed:24116191, PubMed:24462292, PubMed:25131990, PubMed:26300263, PubMed:29976794, PubMed:30799039, PubMed:31142647, PubMed:32814054, PubMed:33273464, PubMed:33542149, PubMed:37217469, PubMed:37802025). Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p] (PubMed:28214358, PubMed:28363908). Acts as a key DNA sensor: directly binds double-stranded DNA (dsDNA), inducing the formation of liquid-like droplets in which CGAS is activated, leading to synthesis of 2',3'-cGAMP, a second messenger that binds to and activates STING1, thereby triggering type-I interferon production (PubMed:28314590, PubMed:28363908, PubMed:29976794, PubMed:32817552, PubMed:33230297, PubMed:33606975, PubMed:35322803, PubMed:35438208, PubMed:35460603, PubMed:35503863). Preferentially recognizes and binds curved long dsDNAs of a minimal length of 40 bp (PubMed:30007416). Acts as a key foreign DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses (PubMed:28363908). Has antiviral activity by sensing the presence of dsDNA from DNA viruses in the cytoplasm (PubMed:28363908, PubMed:35613581). Also acts as an innate immune sensor of infection by retroviruses, such as HIV-2, by detecting the presence of reverse-transcribed DNA in the cytosol (PubMed:23929945, PubMed:24269171, PubMed:30270045, PubMed:32852081). In contrast, HIV-1 is poorly sensed by CGAS, due to its capsid that cloaks viral DNA from CGAS detection (PubMed:24269171, PubMed:30270045, PubMed:32852081). Detection of retroviral reverse-transcribed DNA in the cytosol may be indirect and be mediated via interaction with PQBP1, which directly binds reverse-transcribed retroviral DNA (PubMed:26046437). Also detects the presence of DNA from bacteria, such as M.tuberculosis (PubMed:26048138). 2',3'-cGAMP can be transferred from producing cells to neighboring cells through gap junctions, leading to promote STING1 activation and convey immune response to connecting cells (PubMed:24077100). 2',3'-cGAMP can also be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but STING1-dependent manner (PubMed:26229115). Also senses the presence of neutrophil extracellular traps (NETs) that are translocated to the cytosol following phagocytosis, leading to synthesis of 2',3'-cGAMP (PubMed:33688080). In addition to foreign DNA, can also be activated by endogenous nuclear or mitochondrial DNA (PubMed:28738408, PubMed:28759889, PubMed:31299200, PubMed:33031745, PubMed:33230297). When self-DNA leaks into the cytosol during cellular stress (such as mitochondrial stress, SARS-CoV-2 infection causing severe COVID-19 disease, DNA damage, mitotic arrest or senescence), or is present in form of cytosolic micronuclei, CGAS is activated leading to a state of sterile inflammation (PubMed:28738408, PubMed:28759889, PubMed:31299200, PubMed:33031745, PubMed:33230297, PubMed:35045565). Acts as a regulator of cellular senescence by binding to cytosolic chromatin fragments that are present in senescent cells, leading to trigger type-I interferon production via STING1 and promote cellular senescence (By similarity). Also involved in the inflammatory response to genome instability and double-stranded DNA breaks: acts by localizing to micronuclei arising from genome instability (PubMed:28738408, PubMed:28759889). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, CGAS binds self-DNA exposed to the cytosol, leading to 2',3'-cGAMP synthesis and subsequent activation of STING1 and type-I interferon production (PubMed:28738408, PubMed:28759889). Activated in response to prolonged mitotic arrest, promoting mitotic cell death (PubMed:31299200). In a healthy cell, CGAS is however kept inactive even in cellular events that directly expose it to self-DNA, such as mitosis, when cGAS associates with chromatin directly after nuclear envelope breakdown or remains in the form of postmitotic persistent nuclear cGAS pools bound to chromatin (PubMed:31299200, PubMed:33542149). Nuclear CGAS is inactivated by chromatin via direct interaction with nucleosomes, which block CGAS from DNA binding and thus prevent CGAS-induced autoimmunity (PubMed:31299200, PubMed:32911482, PubMed:32912999, PubMed:33051594, PubMed:33542149). Also acts as a suppressor of DNA repair in response to DNA damage: inhibits homologous recombination repair by interacting with PARP1, the CGAS-PARP1 interaction leading to impede the formation of the PARP1-TIMELESS complex (PubMed:30356214, PubMed:31544964). In addition to DNA, also sense translation stress: in response to translation stress, translocates to the cytosol and associates with collided ribosomes, promoting its activation and triggering type-I interferon production (PubMed:34111399). In contrast to other mammals, human CGAS displays species-specific mechanisms of DNA recognition and produces less 2',3'-cGAMP, allowing a more fine-tuned response to pathogens (PubMed:30007416). {ECO:0000250|UniProtKB:Q8C6L5, ECO:0000269|PubMed:21478870, ECO:0000269|PubMed:23258413, ECO:0000269|PubMed:23707061, ECO:0000269|PubMed:23707065, ECO:0000269|PubMed:23722159, ECO:0000269|PubMed:23929945, ECO:0000269|PubMed:24077100, ECO:0000269|PubMed:24116191, ECO:0000269|PubMed:24269171, ECO:0000269|PubMed:24462292, ECO:0000269|PubMed:25131990, ECO:0000269|PubMed:26046437, ECO:0000269|PubMed:26048138, ECO:0000269|PubMed:26229115, ECO:0000269|PubMed:26300263, ECO:0000269|PubMed:28214358, ECO:0000269|PubMed:28314590, ECO:0000269|PubMed:28363908, ECO:0000269|PubMed:28738408, ECO:0000269|PubMed:28759889, ECO:0000269|PubMed:29976794, ECO:0000269|PubMed:30007416, ECO:0000269|PubMed:30270045, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:30799039, ECO:0000269|PubMed:31142647, ECO:0000269|PubMed:31299200, ECO:0000269|PubMed:31544964, ECO:0000269|PubMed:32814054, ECO:0000269|PubMed:32817552, ECO:0000269|PubMed:32852081, ECO:0000269|PubMed:32911482, ECO:0000269|PubMed:32912999, ECO:0000269|PubMed:33031745, ECO:0000269|PubMed:33051594, ECO:0000269|PubMed:33230297, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33542149, ECO:0000269|PubMed:33606975, ECO:0000269|PubMed:33688080, ECO:0000269|PubMed:34111399, ECO:0000269|PubMed:35045565, ECO:0000269|PubMed:35322803, ECO:0000269|PubMed:35438208, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:35503863, ECO:0000269|PubMed:35613581, ECO:0000269|PubMed:37217469, ECO:0000269|PubMed:37802025}. |
| Q8TD55 | PLEKHO2 | S167 | ochoa | Pleckstrin homology domain-containing family O member 2 (PH domain-containing family O member 2) (Pleckstrin homology domain-containing family Q member 1) (PH domain-containing family Q member 1) | None |
| Q8TDJ6 | DMXL2 | S1143 | ochoa | DmX-like protein 2 (Rabconnectin-3) | May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles (PubMed:11809763). Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity). {ECO:0000250|UniProtKB:Q8BPN8, ECO:0000269|PubMed:11809763}. |
| Q8TDM6 | DLG5 | S1478 | ochoa | Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG) | Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). {ECO:0000250|UniProtKB:E9Q9R9, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:28169360}. |
| Q92499 | DDX1 | S377 | psp | ATP-dependent RNA helicase DDX1 (EC 3.6.4.13) (DEAD box protein 1) (DEAD box protein retinoblastoma) (DBP-RB) | Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 expression. Binds to the cyclin CCND2 promoter region. Associates with chromatin at the NF-kappa-B promoter region via association with RELA. Binds to poly(A) RNA. May be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB: together with archease (ZBTB8OS), acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation (PubMed:24870230). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1. Specifically binds (via helicase ATP-binding domain) on both short and long poly(I:C) dsRNA (By similarity). {ECO:0000250|UniProtKB:Q91VR5, ECO:0000269|PubMed:12183465, ECO:0000269|PubMed:15567440, ECO:0000269|PubMed:18335541, ECO:0000269|PubMed:18710941, ECO:0000269|PubMed:20573827, ECO:0000269|PubMed:24870230}.; FUNCTION: (Microbial infection) Required for HIV-1 Rev function as well as for HIV-1 and coronavirus IBV replication. Binds to the RRE sequence of HIV-1 mRNAs. {ECO:0000269|PubMed:15567440}.; FUNCTION: (Microbial infection) Required for Coronavirus IBV replication. {ECO:0000269|PubMed:20573827}. |
| Q92545 | TMEM131 | S1179 | ochoa | Transmembrane protein 131 (Protein RW1) | Collagen binding transmembrane protein involved in collagen secretion by recruiting the ER-to-Golgi transport complex TRAPPIII (PubMed:32095531). May play a role in the immune response to viral infection. {ECO:0000250, ECO:0000269|PubMed:32095531}. |
| Q92785 | DPF2 | S151 | ochoa | Zinc finger protein ubi-d4 (Apoptosis response zinc finger protein) (BRG1-associated factor 45D) (BAF45D) (D4, zinc and double PHD fingers family 2) (Protein requiem) | Plays an active role in transcriptional regulation by binding modified histones H3 and H4 (PubMed:27775714, PubMed:28533407). Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells (PubMed:28533407). Might also have a role in the development and maturation of lymphoid cells (By similarity). Involved in the regulation of non-canonical NF-kappa-B pathway (PubMed:20460684). {ECO:0000250|UniProtKB:Q61103, ECO:0000269|PubMed:20460684, ECO:0000269|PubMed:27775714, ECO:0000269|PubMed:28533407}. |
| Q92844 | TANK | S225 | ochoa | TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF) | Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989). Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989). May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. {ECO:0000269|PubMed:12133833, ECO:0000269|PubMed:21931631, ECO:0000269|PubMed:25861989}. |
| Q92997 | DVL3 | S137 | ochoa|psp | Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) | Involved in the signal transduction pathway mediated by multiple Wnt genes. {ECO:0000250|UniProtKB:Q61062}. |
| Q969N2 | PIGT | S329 | ochoa | GPI-anchor transamidase component PIGT (Phosphatidylinositol-glycan biosynthesis class T protein) | Component of the glycosylphosphatidylinositol-anchor (GPI-anchor) transamidase (GPI-T) complex that catalyzes the formation of the linkage between a proprotein and a GPI-anchor and participates in GPI anchored protein biosynthesis (PubMed:11483512, PubMed:12582175, PubMed:28327575, PubMed:34576938, PubMed:35165458, PubMed:35551457, PubMed:36970549, PubMed:37684232). May play a crucial role in GPI-T complex assembly in the luminal layer (PubMed:35165458, PubMed:35551457). Binds GPI-anchor (PubMed:37684232). {ECO:0000269|PubMed:11483512, ECO:0000269|PubMed:12582175, ECO:0000269|PubMed:28327575, ECO:0000269|PubMed:34576938, ECO:0000269|PubMed:35165458, ECO:0000269|PubMed:35551457, ECO:0000269|PubMed:36970549, ECO:0000269|PubMed:37684232}. |
| Q96GV9 | MACIR | S165 | ochoa | Macrophage immunometabolism regulator | Regulates the macrophage function, by enhancing the resolution of inflammation and wound repair functions mediated by M2 macrophages (PubMed:30659109). The regulation of macrophage function is, due at least in part, to its ability to inhibit glycolysis (PubMed:30659109). May also play a role in trafficking of proteins via its interaction with UNC119 and UNC119B cargo adapters: may help the release of UNC119 and UNC119B cargo or the recycling of UNC119 and UNC119B (PubMed:22085962). May play a role in ciliary membrane localization via its interaction with UNC119B and protein transport into photoreceptor cells (PubMed:22085962). {ECO:0000269|PubMed:22085962, ECO:0000269|PubMed:30659109}. |
| Q96H22 | CENPN | S235 | ochoa | Centromere protein N (CENP-N) (Interphase centromere complex protein 32) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA nucleosomes by CENPN is required for centromere assembly. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate. {ECO:0000269|PubMed:16622419, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:18007590, ECO:0000269|PubMed:19543270}. |
| Q96IT1 | ZNF496 | S221 | ochoa | Zinc finger protein 496 (Zinc finger protein with KRAB and SCAN domains 17) | DNA-binding transcription factor that can both act as an activator and a repressor. {ECO:0000250}. |
| Q96JK2 | DCAF5 | S533 | ochoa | DDB1- and CUL4-associated factor 5 (Breakpoint cluster region protein 2) (BCRP2) (WD repeat-containing protein 22) | Is a substrate receptor for the CUL4-DDB1 E3 ubiquitin-protein ligase complex (CRL4) (PubMed:29691401, PubMed:30442713). The complex CRL4-DCAF5 is involved in the ubiquitination of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1 (PubMed:29691401, PubMed:30442713). {ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:29691401, ECO:0000269|PubMed:30442713}. |
| Q96Q89 | KIF20B | S1588 | ochoa | Kinesin-like protein KIF20B (Cancer/testis antigen 90) (CT90) (Kinesin family member 20B) (Kinesin-related motor interacting with PIN1) (M-phase phosphoprotein 1) (MPP1) | Plus-end-directed motor enzyme that is required for completion of cytokinesis (PubMed:11470801, PubMed:12740395). Required for proper midbody organization and abscission in polarized cortical stem cells. Plays a role in the regulation of neuronal polarization by mediating the transport of specific cargos. Participates in the mobilization of SHTN1 and in the accumulation of PIP3 in the growth cone of primary hippocampal neurons in a tubulin and actin-dependent manner. In the developing telencephalon, cooperates with SHTN1 to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in cerebral cortex growth (By similarity). Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436). {ECO:0000250|UniProtKB:Q80WE4, ECO:0000269|PubMed:11470801, ECO:0000269|PubMed:12740395, ECO:0000269|PubMed:17409436}. |
| Q96R06 | SPAG5 | S157 | ochoa | Sperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126) | Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase (PubMed:11724960, PubMed:12356910, PubMed:27462074). Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:17664331, PubMed:27462074). In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes (PubMed:18361916, PubMed:21402792). Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis (PubMed:23953116). May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU (PubMed:18055457). {ECO:0000269|PubMed:12356910, ECO:0000269|PubMed:17664331, ECO:0000269|PubMed:18055457, ECO:0000269|PubMed:18361916, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:23953116, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:27462074, ECO:0000305|PubMed:11724960}. |
| Q96RU2 | USP28 | S131 | ochoa | Ubiquitin carboxyl-terminal hydrolase 28 (EC 3.4.19.12) (Deubiquitinating enzyme 28) (Ubiquitin thioesterase 28) (Ubiquitin-specific-processing protease 28) | Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 4 of FBXW7 (FBW7gamma) in the nucleolus, allowing MYC degradation and explaining the selective MYC degradation in the nucleolus. Deubiquitinates ZNF304, hence preventing ZNF304 degradation by the proteasome and leading to the activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) in a subset of colorectal cancers (CRC) cells (PubMed:24623306). {ECO:0000269|PubMed:16901786, ECO:0000269|PubMed:17558397, ECO:0000269|PubMed:17873522, ECO:0000269|PubMed:18662541, ECO:0000269|PubMed:24623306}. |
| Q96S59 | RANBP9 | S550 | psp | Ran-binding protein 9 (RanBP9) (BPM-L) (BPM90) (Ran-binding protein M) (RanBPM) (RanBP7) | May act as scaffolding protein, and as adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Acts as a mediator of cell spreading and actin cytoskeleton rearrangement (PubMed:18710924). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). May be involved in signaling of ITGB2/LFA-1 and other integrins (PubMed:14722085). Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway (PubMed:12147692). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation (PubMed:12361945, PubMed:18222118). Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity (PubMed:15558019). Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA. {ECO:0000269|PubMed:12147692, ECO:0000269|PubMed:12361945, ECO:0000269|PubMed:14500717, ECO:0000269|PubMed:14722085, ECO:0000269|PubMed:15381419, ECO:0000269|PubMed:15558019, ECO:0000269|PubMed:18222118, ECO:0000269|PubMed:18710924, ECO:0000269|PubMed:29911972, ECO:0000305}. |
| Q99567 | NUP88 | S379 | ochoa | Nuclear pore complex protein Nup88 (88 kDa nucleoporin) (Nucleoporin Nup88) | Component of nuclear pore complex. {ECO:0000269|PubMed:30543681}. |
| Q99569 | PKP4 | S461 | ochoa | Plakophilin-4 (p0071) | Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269|PubMed:17115030}. |
| Q99614 | TTC1 | S265 | ochoa | Tetratricopeptide repeat protein 1 (TPR repeat protein 1) | None |
| Q99956 | DUSP9 | S219 | ochoa | Dual specificity protein phosphatase 9 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 4) (MAP kinase phosphatase 4) (MKP-4) | Inactivates MAP kinases. Has a specificity for the ERK family. |
| Q9BQE3 | TUBA1C | S165 | psp | Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9BTC0 | DIDO1 | S330 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
| Q9BTK6 | PAGR1 | S26 | ochoa | PAXIP1-associated glutamate-rich protein 1 (Glutamate-rich coactivator interacting with SRC1) (GAS) (PAXIP1-associated protein 1) (PTIP-associated protein 1) | Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex (PubMed:19124460). However, its function in DNA damage has been questioned (By similarity). During immunoglobulin class switching in activated B-cells is involved in transcription regulation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus independently of the MLL2/MLL3 complex (By similarity). Involved in both estrogen receptor-regulated gene transcription and estrogen-stimulated G1/S cell-cycle transition (PubMed:19039327). Acts as a transcriptional cofactor for nuclear hormone receptors. Inhibits the induction properties of several steroid receptors such as NR3C1, AR and PPARG; the mechanism of inhibition appears to be gene-dependent (PubMed:23161582). {ECO:0000250|UniProtKB:Q99L02, ECO:0000269|PubMed:19039327, ECO:0000269|PubMed:19124460, ECO:0000269|PubMed:23161582, ECO:0000305}. |
| Q9H910 | JPT2 | S125 | ochoa | Jupiter microtubule associated homolog 2 (Hematological and neurological expressed 1-like protein) (HN1-like protein) | Nicotinic acid adenine dinucleotide phosphate (NAADP) binding protein required for NAADP-evoked intracellular calcium release (PubMed:33758061, PubMed:33758062). Confers NAADP-sensitivity to the two pore channels (TPCs) complex (PubMed:33758061). Enables NAADP to activate Ca(2+) release from the endoplasmic reticulum through ryanodine receptors (PubMed:33758062). {ECO:0000269|PubMed:33758061, ECO:0000269|PubMed:33758062}.; FUNCTION: (Microbial infection) Involved in the endolysosomal trafficking of human coronavirus SARS-CoV-2. {ECO:0000269|PubMed:33758061}. |
| Q9HCH5 | SYTL2 | S540 | ochoa | Synaptotagmin-like protein 2 (Breast cancer-associated antigen SGA-72M) (Exophilin-4) | Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive. {ECO:0000269|PubMed:17182843, ECO:0000269|PubMed:18266782, ECO:0000269|PubMed:18812475}. |
| Q9NS87 | KIF15 | S1083 | ochoa | Kinesin-like protein KIF15 (Kinesin-like protein 2) (hKLP2) (Kinesin-like protein 7) (Serologically defined breast cancer antigen NY-BR-62) | Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly. {ECO:0000250}. |
| Q9NX95 | SYBU | S396 | ochoa | Syntabulin (Golgi-localized syntaphilin-related protein) (Syntaxin-1-binding protein) | Part of a kinesin motor-adapter complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development. {ECO:0000250, ECO:0000269|PubMed:15459722}. |
| Q9P0J1 | PDP1 | S292 | psp | [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial (PDP 1) (EC 3.1.3.43) (Protein phosphatase 2C) (Pyruvate dehydrogenase phosphatase catalytic subunit 1) (PDPC 1) | Mitochondrial enzyme that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (PDC), thereby stimulating the conversion of pyruvate into acetyl-CoA. {ECO:0000269|PubMed:15554715, ECO:0000305|PubMed:15855260}. |
| Q9P2J5 | LARS1 | S720 | ochoa | Leucine--tRNA ligase, cytoplasmic (EC 6.1.1.4) (Leucyl-tRNA synthetase) (LeuRS) (cLRS) | Aminoacyl-tRNA synthetase that catalyzes the specific attachment of leucine to its cognate tRNA (tRNA(Leu)) (PubMed:25051973, PubMed:32232361). It performs tRNA aminoacylation in a two-step reaction: Leu is initially activated by ATP to form a leucyl-adenylate (Leu-AMP) intermediate; then the leucyl moiety is transferred to the acceptor 3' end of the tRNA to yield leucyl-tRNA (PubMed:25051973). To improve the fidelity of catalytic reactions, it is also able to hydrolyze misactivated aminoacyl-adenylate intermediates (pre-transfer editing) and mischarged aminoacyl-tRNAs (post-transfer editing) (PubMed:25051973). {ECO:0000269|PubMed:19426743, ECO:0000269|PubMed:25051973, ECO:0000269|PubMed:32232361}. |
| Q9P2Y5 | UVRAG | S522 | ochoa|psp | UV radiation resistance-associated gene protein (p63) | Versatile protein that is involved in regulation of different cellular pathways implicated in membrane trafficking. Involved in regulation of the COPI-dependent retrograde transport from Golgi and the endoplasmic reticulum by associating with the NRZ complex; the function is dependent on its binding to phosphatidylinositol 3-phosphate (PtdIns(3)P) (PubMed:16799551, PubMed:18552835, PubMed:20643123, PubMed:24056303, PubMed:28306502). During autophagy acts as a regulatory subunit of the alternative PI3K complex II (PI3KC3-C2) that mediates formation of phosphatidylinositol 3-phosphate and is believed to be involved in maturation of autophagosomes and endocytosis. Activates lipid kinase activity of PIK3C3 (PubMed:16799551, PubMed:20643123, PubMed:24056303, PubMed:28306502). Involved in the regulation of degradative endocytic trafficking and cytokinesis, and in regulation of ATG9A transport from the Golgi to the autophagosome; the functions seems to implicate its association with PI3KC3-C2 (PubMed:16799551, PubMed:20643123, PubMed:24056303). Involved in maturation of autophagosomes and degradative endocytic trafficking independently of BECN1 but depending on its association with a class C Vps complex (possibly the HOPS complex); the association is also proposed to promote autophagosome recruitment and activation of Rab7 and endosome-endosome fusion events (PubMed:18552835, PubMed:28306502). Enhances class C Vps complex (possibly HOPS complex) association with a SNARE complex and promotes fusogenic SNARE complex formation during late endocytic membrane fusion (PubMed:24550300). In case of negative-strand RNA virus infection is required for efficient virus entry, promotes endocytic transport of virions and is implicated in a VAMP8-specific fusogenic SNARE complex assembly (PubMed:24550300). {ECO:0000269|PubMed:18552835, ECO:0000269|PubMed:20643123, ECO:0000269|PubMed:24056303, ECO:0000269|PubMed:28306502, ECO:0000305}.; FUNCTION: Involved in maintaining chromosomal stability. Promotes DNA double-strand break (DSB) repair by association with DNA-dependent protein kinase complex DNA-PK and activating it in non-homologous end joining (NHEJ) (PubMed:22542840). Required for centrosome stability and proper chromosome segregation (PubMed:22542840). {ECO:0000269|PubMed:22542840}. |
| Q9UHE8 | STEAP1 | S36 | ochoa | STEAP1 protein (Six-transmembrane epithelial antigen of prostate 1) | Does not function as a metalloreductase due to the absence of binding sites for the electron-donating substrate NADPH. Promotes Fe(3+) reduction when fused to the NADPH-binding domain of STEAP4. {ECO:0000269|PubMed:32409586}. |
| Q9UIG8 | SLCO3A1 | S671 | ochoa | Solute carrier organic anion transporter family member 3A1 (OATP3A1) (Organic anion transporter polypeptide-related protein 3) (OATP-RP3) (OATPRP3) (Organic anion-transporting polypeptide D) (OATP-D) (PGE1 transporter) (Sodium-independent organic anion transporter D) (Solute carrier family 21 member 11) | Putative organic anion antiporter with apparent broad substrate specificity. Recognizes various substrates including thyroid hormone L-thyroxine, prostanoids such as prostaglandin E1 and E2, bile acids such as taurocholate, glycolate and glycochenodeoxycholate and peptide hormones such as L-arginine vasopressin, likely operating in a tissue-specific manner (PubMed:10873595, PubMed:14631946, PubMed:16971491, PubMed:19129463, PubMed:30063921). The transport mechanism, its electrogenicity and potential tissue-specific counterions remain to be elucidated (Probable). {ECO:0000269|PubMed:10873595, ECO:0000269|PubMed:14631946, ECO:0000269|PubMed:16971491, ECO:0000269|PubMed:19129463, ECO:0000269|PubMed:30063921, ECO:0000305}. |
| Q9UJY1 | HSPB8 | S24 | ochoa|psp | Heat shock protein beta-8 (HspB8) (Alpha-crystallin C chain) (E2-induced gene 1 protein) (Heat shock protein family B member 8) (Protein kinase H11) (Small stress protein-like protein HSP22) | Involved in the chaperone-assisted selective autophagy (CASA), a crucial process for protein quality control, particularly in mechanical strained cells and tissues such as muscle. Displays temperature-dependent chaperone activity. {ECO:0000250|UniProtKB:Q9JK92}. |
| Q9UKT4 | FBXO5 | S149 | psp | F-box only protein 5 (Early mitotic inhibitor 1) | Regulator of APC activity during mitotic and meiotic cell cycle (PubMed:16921029, PubMed:17234884, PubMed:17485488, PubMed:17875940, PubMed:23708001, PubMed:23708605). During mitotic cell cycle plays a role as both substrate and inhibitor of APC-FZR1 complex (PubMed:16921029, PubMed:17234884, PubMed:17485488, PubMed:17875940, PubMed:23708001, PubMed:23708605, PubMed:29875408). During G1 phase, plays a role as substrate of APC-FZR1 complex E3 ligase (PubMed:29875408). Then switches as an inhibitor of APC-FZR1 complex during S and G2 leading to cell-cycle commitment (PubMed:29875408). As APC inhibitor, prevents the degradation of APC substrates at multiple levels: by interacting with APC and blocking access of APC substrates to the D-box coreceptor, formed by FZR1 and ANAPC10; by suppressing ubiquitin ligation and chain elongation by APC by preventing the UBE2C and UBE2S activities (PubMed:16921029, PubMed:23708001, PubMed:23708605). Plays a role in genome integrity preservation by coordinating DNA replication with mitosis through APC inhibition in interphase to stabilize CCNA2 and GMNN in order to promote mitosis and prevent rereplication and DNA damage-induced cellular senescence (PubMed:17234884, PubMed:17485488, PubMed:17875940). During oocyte maturation, plays a role in meiosis through inactivation of APC-FZR1 complex. Inhibits APC through RPS6KA2 interaction that increases FBXO5 affiniy for CDC20 leading to the metaphase arrest of the second meiotic division before fertilization (By similarity). Controls entry into the first meiotic division through inactivation of APC-FZR1 complex (By similarity). Promotes migration and osteogenic differentiation of mesenchymal stem cells (PubMed:29850565). {ECO:0000250|UniProtKB:Q7TSG3, ECO:0000269|PubMed:16921029, ECO:0000269|PubMed:17234884, ECO:0000269|PubMed:17485488, ECO:0000269|PubMed:17875940, ECO:0000269|PubMed:23708001, ECO:0000269|PubMed:23708605, ECO:0000269|PubMed:29850565, ECO:0000269|PubMed:29875408}. |
| Q9Y4F1 | FARP1 | S510 | ochoa | FERM, ARHGEF and pleckstrin domain-containing protein 1 (Chondrocyte-derived ezrin-like protein) (FERM, RhoGEF and pleckstrin domain-containing protein 1) (Pleckstrin homology domain-containing family C member 2) (PH domain-containing family C member 2) | Functions as a guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). {ECO:0000250}. |
| Q9Y6Q9 | NCOA3 | S1062 | psp | Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. |
| O14733 | MAP2K7 | S89 | Sugiyama | Dual specificity mitogen-activated protein kinase kinase 7 (MAP kinase kinase 7) (MAPKK 7) (EC 2.7.12.2) (JNK-activating kinase 2) (MAPK/ERK kinase 7) (MEK 7) (Stress-activated protein kinase kinase 4) (SAPK kinase 4) (SAPKK-4) (SAPKK4) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2) | Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by pro-inflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Part of a non-canonical MAPK signaling pathway, composed of the upstream MAP3K12 kinase and downstream MAP kinases MAPK1/ERK2 and MAPK3/ERK1, that enhances the AP-1-mediated transcription of APP in response to APOE (PubMed:28111074). {ECO:0000269|PubMed:28111074, ECO:0000269|PubMed:9312068, ECO:0000269|PubMed:9372971, ECO:0000269|PubMed:9535930, ECO:0000269|Ref.5}. |
| P30044 | PRDX5 | S171 | Sugiyama | Peroxiredoxin-5, mitochondrial (EC 1.11.1.24) (Alu corepressor 1) (Antioxidant enzyme B166) (AOEB166) (Liver tissue 2D-page spot 71B) (PLP) (Peroxiredoxin V) (Prx-V) (Peroxisomal antioxidant enzyme) (TPx type VI) (Thioredoxin peroxidase PMP20) (Thioredoxin-dependent peroxiredoxin 5) | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. {ECO:0000269|PubMed:10514471, ECO:0000269|PubMed:10521424, ECO:0000269|PubMed:10751410, ECO:0000269|PubMed:31740833}. |
| Q6ULP2 | AFTPH | S328 | Sugiyama | Aftiphilin | Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025}. |
| P46060 | RANGAP1 | S454 | Sugiyama | Ran GTPase-activating protein 1 (RanGAP1) | GTPase activator for RAN (PubMed:16428860, PubMed:8146159, PubMed:8896452). Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export (PubMed:27160050, PubMed:8896452). Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export (PubMed:27160050). {ECO:0000269|PubMed:16428860, ECO:0000269|PubMed:27160050, ECO:0000269|PubMed:8146159, ECO:0000269|PubMed:8896452}. |
| Q9Y6A5 | TACC3 | S552 | SIGNOR | Transforming acidic coiled-coil-containing protein 3 (ERIC-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476). {ECO:0000250|UniProtKB:Q9JJ11, ECO:0000269|PubMed:14767476, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}. |
| O15111 | CHUK | S381 | Sugiyama | Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16) | Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues (PubMed:18626576, PubMed:35952808, PubMed:9244310, PubMed:9252186, PubMed:9346484). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11) (PubMed:21765415). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes (PubMed:20501937). In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis. Also participates in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilizing MAP3K14/NIK. Within the nucleus, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities (PubMed:17434128). Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at 'Ser-10' that are subsequently acetylated at 'Lys-14' by CREBBP (PubMed:12789342). Additionally, phosphorylates the CREBBP-interacting protein NCOA3. Also phosphorylates FOXO3 and may regulate this pro-apoptotic transcription factor (PubMed:15084260). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates AMBRA1 following mitophagy induction, promoting AMBRA1 interaction with ATG8 family proteins and its mitophagic activity (PubMed:30217973). {ECO:0000250|UniProtKB:Q60680, ECO:0000269|PubMed:12789342, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17434128, ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20501937, ECO:0000269|PubMed:21765415, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35952808, ECO:0000269|PubMed:9244310, ECO:0000269|PubMed:9252186, ECO:0000269|PubMed:9346484, ECO:0000303|PubMed:18626576}. |
| P46776 | RPL27A | S83 | Sugiyama | Large ribosomal subunit protein uL15 (60S ribosomal protein L27a) | Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| O95425 | SVIL | S130 | Sugiyama | Supervillin (Archvillin) (p205/p250) | [Isoform 1]: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699). Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (PubMed:19109420). {ECO:0000269|PubMed:12711699, ECO:0000269|PubMed:19109420}.; FUNCTION: [Isoform 2]: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity). {ECO:0000250|UniProtKB:O46385}. |
| Q9NY33 | DPP3 | S228 | Sugiyama | Dipeptidyl peptidase 3 (EC 3.4.14.4) (Dipeptidyl aminopeptidase III) (Dipeptidyl arylamidase III) (Dipeptidyl peptidase III) (DPP III) (Enkephalinase B) | Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin (PubMed:1515063, PubMed:3233187). Also cleaves Arg-Arg-beta-naphthylamide (in vitro) (PubMed:11209758, PubMed:3233187, PubMed:9425109). {ECO:0000269|PubMed:11209758, ECO:0000269|PubMed:1515063, ECO:0000269|PubMed:3233187, ECO:0000269|PubMed:9425109}. |
| O60566 | BUB1B | S25 | Sugiyama | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1) | Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. {ECO:0000269|PubMed:10477750, ECO:0000269|PubMed:11702782, ECO:0000269|PubMed:14706340, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:19411850, ECO:0000269|PubMed:19503101}. |
| P28329 | CHAT | S558 | SIGNOR|EPSD | Choline O-acetyltransferase (CHOACTase) (ChAT) (Choline acetylase) (EC 2.3.1.6) | Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses. {ECO:0000269|PubMed:17144655}. |
| P07333 | CSF1R | S807 | Sugiyama | Macrophage colony-stimulating factor 1 receptor (CSF-1 receptor) (CSF-1-R) (CSF-1R) (M-CSF-R) (EC 2.7.10.1) (Proto-oncogene c-Fms) (CD antigen CD115) | Tyrosine-protein kinase that acts as a cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of pro-inflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding, including the ERK1/2 and the JNK pathway (PubMed:20504948, PubMed:30982609). Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL. Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, that then lead to the activation of protein kinase C family members, especially PRKCD. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1. Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2. Promotes activation of STAT family members STAT3, STAT5A and/or STAT5B. Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP-1. Receptor signaling is down-regulated by protein phosphatases, such as INPP5D/SHIP-1, that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor. In the central nervous system, may play a role in the development of microglia macrophages (PubMed:30982608). {ECO:0000269|PubMed:12882960, ECO:0000269|PubMed:15117969, ECO:0000269|PubMed:16170366, ECO:0000269|PubMed:16337366, ECO:0000269|PubMed:16648572, ECO:0000269|PubMed:17121910, ECO:0000269|PubMed:18467591, ECO:0000269|PubMed:18814279, ECO:0000269|PubMed:19193011, ECO:0000269|PubMed:19934330, ECO:0000269|PubMed:20489731, ECO:0000269|PubMed:20504948, ECO:0000269|PubMed:20829061, ECO:0000269|PubMed:30982608, ECO:0000269|PubMed:30982609, ECO:0000269|PubMed:7683918}. |
| P11047 | LAMC1 | S348 | Sugiyama | Laminin subunit gamma-1 (Laminin B2 chain) (Laminin-1 subunit gamma) (Laminin-10 subunit gamma) (Laminin-11 subunit gamma) (Laminin-2 subunit gamma) (Laminin-3 subunit gamma) (Laminin-4 subunit gamma) (Laminin-6 subunit gamma) (Laminin-7 subunit gamma) (Laminin-8 subunit gamma) (Laminin-9 subunit gamma) (S-laminin subunit gamma) (S-LAM gamma) | Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. |
| P16234 | PDGFRA | S847 | Sugiyama | Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a) | Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor. {ECO:0000269|PubMed:10734113, ECO:0000269|PubMed:10947961, ECO:0000269|PubMed:11297552, ECO:0000269|PubMed:12522257, ECO:0000269|PubMed:1646396, ECO:0000269|PubMed:17087943, ECO:0000269|PubMed:1709159, ECO:0000269|PubMed:17141222, ECO:0000269|PubMed:20972453, ECO:0000269|PubMed:21224473, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:2554309, ECO:0000269|PubMed:8188664, ECO:0000269|PubMed:8760137, ECO:0000269|PubMed:8943348}. |
| Q6ZN44 | UNC5A | S352 | SIGNOR | Netrin receptor UNC5A (Protein unc-5 homolog 1) (Protein unc-5 homolog A) | Receptor for netrin required for axon guidance. Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1. Mediates axon repulsion of neuronal growth cones in the developing nervous system in response to netrin. Axon repulsion in growth cones may be mediated by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. {ECO:0000250|UniProtKB:O08721}. |
| P17948 | FLT1 | S1031 | Sugiyama | Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase FRT) (Tyrosine-protein kinase receptor FLT) (FLT) (Vascular permeability factor receptor) | Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. Acts as a positive regulator of postnatal retinal hyaloid vessel regression (By similarity). May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC and YES1, and may also phosphorylate CBL. Promotes phosphorylation of AKT1 at 'Ser-473'. Promotes phosphorylation of PTK2/FAK1 (PubMed:16685275). {ECO:0000250|UniProtKB:P35969, ECO:0000269|PubMed:11141500, ECO:0000269|PubMed:11312102, ECO:0000269|PubMed:11811792, ECO:0000269|PubMed:12796773, ECO:0000269|PubMed:14633857, ECO:0000269|PubMed:15735759, ECO:0000269|PubMed:16685275, ECO:0000269|PubMed:18079407, ECO:0000269|PubMed:18515749, ECO:0000269|PubMed:18583712, ECO:0000269|PubMed:18593464, ECO:0000269|PubMed:20512933, ECO:0000269|PubMed:20551949, ECO:0000269|PubMed:21752276, ECO:0000269|PubMed:7824266, ECO:0000269|PubMed:8248162, ECO:0000269|PubMed:8605350, ECO:0000269|PubMed:9299537, ECO:0000269|Ref.11}.; FUNCTION: [Isoform 1]: Phosphorylates PLCG. {ECO:0000269|PubMed:9299537}.; FUNCTION: [Isoform 2]: May function as decoy receptor for VEGFA. {ECO:0000269|PubMed:21752276}.; FUNCTION: [Isoform 3]: May function as decoy receptor for VEGFA. {ECO:0000269|PubMed:21752276}.; FUNCTION: [Isoform 4]: May function as decoy receptor for VEGFA. {ECO:0000269|PubMed:21752276}.; FUNCTION: [Isoform 7]: Has a truncated kinase domain; it increases phosphorylation of SRC at 'Tyr-418' by unknown means and promotes tumor cell invasion. {ECO:0000269|PubMed:20512933}. |
| P08195 | SLC3A2 | S286 | Sugiyama | Amino acid transporter heavy chain SLC3A2 (4F2 cell-surface antigen heavy chain) (4F2hc) (4F2 heavy chain antigen) (Lymphocyte activation antigen 4F2 large subunit) (Solute carrier family 3 member 2) (CD antigen CD98) | Acts as a chaperone that facilitates biogenesis and trafficking of functional transporters heterodimers to the plasma membrane. Forms heterodimer with SLC7 family transporters (SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A10 and SLC7A11), a group of amino-acid antiporters (PubMed:10574970, PubMed:10903140, PubMed:11557028, PubMed:30867591, PubMed:33298890, PubMed:33758168, PubMed:34880232, PubMed:9751058, PubMed:9829974, PubMed:9878049). Heterodimers function as amino acids exchangers, the specificity of the substrate depending on the SLC7A subunit. Heterodimers SLC3A2/SLC7A6 or SLC3A2/SLC7A7 mediate the uptake of dibasic amino acids (PubMed:10903140, PubMed:9829974). Heterodimer SLC3A2/SLC7A11 functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane (PubMed:34880232). SLC3A2/SLC7A10 translocates small neutral L- and D-amino acids across the plasma membrane (By similarity). SLC3A2/SLC75 or SLC3A2/SLC7A8 translocates neutral amino acids with broad specificity, thyroid hormones and L-DOPA (PubMed:10574970, PubMed:11389679, PubMed:11557028, PubMed:11564694, PubMed:11742812, PubMed:12117417, PubMed:12225859, PubMed:12716892, PubMed:15980244, PubMed:30867591, PubMed:33298890, PubMed:33758168). SLC3A2 is essential for plasma membrane localization, stability, and the transport activity of SLC7A5 and SLC7A8 (PubMed:10391915, PubMed:10574970, PubMed:11311135, PubMed:15769744, PubMed:33066406). When associated with LAPTM4B, the heterodimer SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation (PubMed:25998567). Modulates integrin-related signaling and is essential for integrin-dependent cell spreading, migration and tumor progression (PubMed:11121428, PubMed:15625115). {ECO:0000250|UniProtKB:P63115, ECO:0000269|PubMed:10391915, ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:10903140, ECO:0000269|PubMed:11121428, ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:11389679, ECO:0000269|PubMed:11557028, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:11742812, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:12716892, ECO:0000269|PubMed:15625115, ECO:0000269|PubMed:15769744, ECO:0000269|PubMed:15980244, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:33066406, ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:33758168, ECO:0000269|PubMed:34880232, ECO:0000269|PubMed:9751058, ECO:0000269|PubMed:9829974, ECO:0000269|PubMed:9878049}.; FUNCTION: (Microbial infection) In case of hepatitis C virus/HCV infection, the complex formed by SLC3A2 and SLC7A5/LAT1 plays a role in HCV propagation by facilitating viral entry into host cell and increasing L-leucine uptake-mediated mTORC1 signaling activation, thereby contributing to HCV-mediated pathogenesis. {ECO:0000269|PubMed:30341327}.; FUNCTION: (Microbial infection) Acts as a receptor for malaria parasite Plasmodium vivax (Thai isolate) in immature red blood cells. {ECO:0000269|PubMed:34294905}. |
| Q00610 | CLTC | S902 | Sugiyama | Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17) | Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872). Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilization of the lattice promoting uncoating (By similarity). {ECO:0000250|UniProtKB:P49951, ECO:0000269|PubMed:15858577, ECO:0000269|PubMed:16968737, ECO:0000269|PubMed:20639872, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}. |
| P35916 | FLT4 | S1046 | Sugiyama | Vascular endothelial growth factor receptor 3 (VEGFR-3) (EC 2.7.10.1) (Fms-like tyrosine kinase 4) (FLT-4) (Tyrosine-protein kinase receptor FLT4) | Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'. {ECO:0000269|PubMed:11532940, ECO:0000269|PubMed:15102829, ECO:0000269|PubMed:15474514, ECO:0000269|PubMed:16076871, ECO:0000269|PubMed:16452200, ECO:0000269|PubMed:17210781, ECO:0000269|PubMed:19610651, ECO:0000269|PubMed:19779139, ECO:0000269|PubMed:20224550, ECO:0000269|PubMed:20431062, ECO:0000269|PubMed:20445537, ECO:0000269|PubMed:21273538, ECO:0000269|PubMed:7675451, ECO:0000269|PubMed:8700872, ECO:0000269|PubMed:9435229}. |
| P36888 | FLT3 | S840 | Sugiyama | Receptor-type tyrosine-protein kinase FLT3 (EC 2.7.10.1) (FL cytokine receptor) (Fetal liver kinase-2) (FLK-2) (Fms-like tyrosine kinase 3) (FLT-3) (Stem cell tyrosine kinase 1) (STK-1) (CD antigen CD135) | Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways. {ECO:0000269|PubMed:10080542, ECO:0000269|PubMed:11090077, ECO:0000269|PubMed:14504097, ECO:0000269|PubMed:16266983, ECO:0000269|PubMed:16627759, ECO:0000269|PubMed:18490735, ECO:0000269|PubMed:20111072, ECO:0000269|PubMed:21067588, ECO:0000269|PubMed:21262971, ECO:0000269|PubMed:21516120, ECO:0000269|PubMed:7507245}. |
| P49760 | CLK2 | S167 | Sugiyama | Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2) | Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Phosphorylates PAGE4 at several serine and threonine residues and this phosphorylation attenuates the ability of PAGE4 to potentiate the transcriptional activator activity of JUN (PubMed:28289210). {ECO:0000269|PubMed:10480872, ECO:0000269|PubMed:19168442, ECO:0000269|PubMed:28289210, ECO:0000269|PubMed:8910305, ECO:0000269|PubMed:9637771}. |
| Q14697 | GANAB | S169 | Sugiyama | Neutral alpha-glucosidase AB (EC 3.2.1.207) (Alpha-glucosidase 2) (Glucosidase II subunit alpha) | Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:10929008). Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia (PubMed:27259053). {ECO:0000269|PubMed:10929008, ECO:0000269|PubMed:27259053}. |
| P60842 | EIF4A1 | S189 | Sugiyama | Eukaryotic initiation factor 4A-I (eIF-4A-I) (eIF4A-I) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-1) | ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome (PubMed:20156963). In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. As a result, promotes cell proliferation and growth (PubMed:20156963). {ECO:0000269|PubMed:19153607, ECO:0000269|PubMed:19204291, ECO:0000269|PubMed:20156963}. |
| Q14240 | EIF4A2 | S190 | Sugiyama | Eukaryotic initiation factor 4A-II (eIF-4A-II) (eIF4A-II) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-2) | ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. |
| Q9UL51 | HCN2 | S668 | SIGNOR | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2) | Hyperpolarization-activated ion channel that is permeable to sodium and potassium ions. Displays lower selectivity for K(+) over Na(+) ions (PubMed:10228147, PubMed:22006928). Contributes to the native pacemaker currents in heart (If) and in neurons (Ih) (PubMed:10228147, PubMed:10524219). Can also transport ammonium in the distal nephron (By similarity). Involved in the initiation of neuropathic pain in sensory neurons (By similarity). {ECO:0000250|UniProtKB:Q9JKA9, ECO:0000269|PubMed:10228147, ECO:0000269|PubMed:10524219, ECO:0000269|PubMed:22006928}. |
| Q8WU90 | ZC3H15 | S135 | Sugiyama | Zinc finger CCCH domain-containing protein 15 (DRG family-regulatory protein 1) (Likely ortholog of mouse immediate early response erythropoietin 4) | Protects DRG1 from proteolytic degradation (PubMed:19819225). Stimulates DRG1 GTPase activity likely by increasing the affinity for the potassium ions (PubMed:23711155). {ECO:0000269|PubMed:19819225, ECO:0000269|PubMed:23711155}. |
| Q99627 | COPS8 | S157 | Sugiyama | COP9 signalosome complex subunit 8 (SGN8) (Signalosome subunit 8) (COP9 homolog) (hCOP9) (JAB1-containing signalosome subunit 8) | Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}. |
| Q9HBH9 | MKNK2 | S442 | Sugiyama | MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (MAPK signal-integrating kinase 2) (Mnk2) | Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal. {ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:11463832, ECO:0000269|PubMed:12897141, ECO:0000269|PubMed:16111636, ECO:0000269|PubMed:17965020, ECO:0000269|PubMed:18299328, ECO:0000269|PubMed:20823271, ECO:0000269|PubMed:20927323, ECO:0000269|PubMed:21149447}. |
| Q08AD1 | CAMSAP2 | S476 | Sugiyama | Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919, ECO:0000269|PubMed:24908486, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28726242}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 1.381792e-08 | 7.860 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 6.495616e-09 | 8.187 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 1.381792e-08 | 7.860 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 1.381792e-08 | 7.860 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 6.345703e-08 | 7.198 |
| R-HSA-114452 | Activation of BH3-only proteins | 6.029670e-08 | 7.220 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 4.114148e-07 | 6.386 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 2.284142e-06 | 5.641 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 2.792382e-06 | 5.554 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 6.952612e-06 | 5.158 |
| R-HSA-170670 | Adenylate cyclase inhibitory pathway | 8.652226e-06 | 5.063 |
| R-HSA-109581 | Apoptosis | 1.157187e-05 | 4.937 |
| R-HSA-180897 | Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabiliza... | 2.791437e-05 | 4.554 |
| R-HSA-162582 | Signal Transduction | 3.656937e-05 | 4.437 |
| R-HSA-5357801 | Programmed Cell Death | 9.728759e-05 | 4.012 |
| R-HSA-373760 | L1CAM interactions | 1.094479e-04 | 3.961 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 1.186750e-04 | 3.926 |
| R-HSA-9634597 | GPER1 signaling | 1.594948e-04 | 3.797 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 1.876788e-04 | 3.727 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 1.830998e-04 | 3.737 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 2.364385e-04 | 3.626 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 2.430725e-04 | 3.614 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 2.643673e-04 | 3.578 |
| R-HSA-1640170 | Cell Cycle | 2.775738e-04 | 3.557 |
| R-HSA-418597 | G alpha (z) signalling events | 2.981965e-04 | 3.525 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 3.019918e-04 | 3.520 |
| R-HSA-392518 | Signal amplification | 3.154620e-04 | 3.501 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 4.797745e-04 | 3.319 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 5.141719e-04 | 3.289 |
| R-HSA-392170 | ADP signalling through P2Y purinoceptor 12 | 5.408046e-04 | 3.267 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 5.835781e-04 | 3.234 |
| R-HSA-69620 | Cell Cycle Checkpoints | 6.464145e-04 | 3.189 |
| R-HSA-112040 | G-protein mediated events | 7.390740e-04 | 3.131 |
| R-HSA-991365 | Activation of GABAB receptors | 7.687262e-04 | 3.114 |
| R-HSA-977444 | GABA B receptor activation | 7.687262e-04 | 3.114 |
| R-HSA-162909 | Host Interactions of HIV factors | 8.337305e-04 | 3.079 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 1.041897e-03 | 2.982 |
| R-HSA-109582 | Hemostasis | 1.064673e-03 | 2.973 |
| R-HSA-111885 | Opioid Signalling | 1.327301e-03 | 2.877 |
| R-HSA-211736 | Stimulation of the cell death response by PAK-2p34 | 1.511797e-03 | 2.821 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 1.578457e-03 | 2.802 |
| R-HSA-68886 | M Phase | 1.863746e-03 | 2.730 |
| R-HSA-8953897 | Cellular responses to stimuli | 2.032218e-03 | 2.692 |
| R-HSA-5683057 | MAPK family signaling cascades | 2.275079e-03 | 2.643 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 2.425612e-03 | 2.615 |
| R-HSA-9706374 | FLT3 signaling through SRC family kinases | 3.339381e-03 | 2.476 |
| R-HSA-1296061 | HCN channels | 3.339381e-03 | 2.476 |
| R-HSA-205025 | NADE modulates death signalling | 3.339381e-03 | 2.476 |
| R-HSA-977443 | GABA receptor activation | 2.921734e-03 | 2.534 |
| R-HSA-199991 | Membrane Trafficking | 3.078717e-03 | 2.512 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 2.857710e-03 | 2.544 |
| R-HSA-422475 | Axon guidance | 2.892096e-03 | 2.539 |
| R-HSA-9824446 | Viral Infection Pathways | 3.194431e-03 | 2.496 |
| R-HSA-5663205 | Infectious disease | 3.085350e-03 | 2.511 |
| R-HSA-381070 | IRE1alpha activates chaperones | 3.270051e-03 | 2.485 |
| R-HSA-68877 | Mitotic Prometaphase | 3.354125e-03 | 2.474 |
| R-HSA-2028269 | Signaling by Hippo | 3.858476e-03 | 2.414 |
| R-HSA-69481 | G2/M Checkpoints | 4.241513e-03 | 2.372 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 4.316410e-03 | 2.365 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 4.503616e-03 | 2.346 |
| R-HSA-447038 | NrCAM interactions | 4.503616e-03 | 2.346 |
| R-HSA-449836 | Other interleukin signaling | 4.907923e-03 | 2.309 |
| R-HSA-9614085 | FOXO-mediated transcription | 4.923692e-03 | 2.308 |
| R-HSA-195399 | VEGF binds to VEGFR leading to receptor dimerization | 5.828431e-03 | 2.234 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 5.701090e-03 | 2.244 |
| R-HSA-194313 | VEGF ligand-receptor interactions | 5.828431e-03 | 2.234 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 5.701090e-03 | 2.244 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 5.315548e-03 | 2.274 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 5.955698e-03 | 2.225 |
| R-HSA-9675108 | Nervous system development | 5.394071e-03 | 2.268 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 6.288644e-03 | 2.201 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 6.527189e-03 | 2.185 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 6.694351e-03 | 2.174 |
| R-HSA-166208 | mTORC1-mediated signalling | 7.481827e-03 | 2.126 |
| R-HSA-164944 | Nef and signal transduction | 7.309163e-03 | 2.136 |
| R-HSA-5653656 | Vesicle-mediated transport | 6.907010e-03 | 2.161 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 7.694348e-03 | 2.114 |
| R-HSA-9679506 | SARS-CoV Infections | 7.843993e-03 | 2.105 |
| R-HSA-429947 | Deadenylation of mRNA | 9.016766e-03 | 2.045 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 9.267797e-03 | 2.033 |
| R-HSA-69278 | Cell Cycle, Mitotic | 9.283403e-03 | 2.032 |
| R-HSA-9702506 | Drug resistance of FLT3 mutants | 1.393706e-02 | 1.856 |
| R-HSA-9669937 | Drug resistance of KIT mutants | 1.393706e-02 | 1.856 |
| R-HSA-9674415 | Drug resistance of PDGFR mutants | 1.393706e-02 | 1.856 |
| R-HSA-9669921 | KIT mutants bind TKIs | 1.393706e-02 | 1.856 |
| R-HSA-9674428 | PDGFR mutants bind TKIs | 1.393706e-02 | 1.856 |
| R-HSA-9702509 | FLT3 mutants bind TKIs | 1.393706e-02 | 1.856 |
| R-HSA-9702632 | sunitinib-resistant FLT3 mutants | 1.393706e-02 | 1.856 |
| R-HSA-9702581 | crenolanib-resistant FLT3 mutants | 1.393706e-02 | 1.856 |
| R-HSA-9703009 | tamatinib-resistant FLT3 mutants | 1.393706e-02 | 1.856 |
| R-HSA-9669917 | Imatinib-resistant KIT mutants | 1.393706e-02 | 1.856 |
| R-HSA-9702577 | semaxanib-resistant FLT3 mutants | 1.393706e-02 | 1.856 |
| R-HSA-9702600 | midostaurin-resistant FLT3 mutants | 1.393706e-02 | 1.856 |
| R-HSA-9702590 | gilteritinib-resistant FLT3 mutants | 1.393706e-02 | 1.856 |
| R-HSA-9669926 | Nilotinib-resistant KIT mutants | 1.393706e-02 | 1.856 |
| R-HSA-9702620 | quizartinib-resistant FLT3 mutants | 1.393706e-02 | 1.856 |
| R-HSA-9669914 | Dasatinib-resistant KIT mutants | 1.393706e-02 | 1.856 |
| R-HSA-9674403 | Regorafenib-resistant PDGFR mutants | 1.393706e-02 | 1.856 |
| R-HSA-9702569 | KW2449-resistant FLT3 mutants | 1.393706e-02 | 1.856 |
| R-HSA-9669934 | Sunitinib-resistant KIT mutants | 1.393706e-02 | 1.856 |
| R-HSA-9674404 | Sorafenib-resistant PDGFR mutants | 1.393706e-02 | 1.856 |
| R-HSA-9702636 | tandutinib-resistant FLT3 mutants | 1.393706e-02 | 1.856 |
| R-HSA-9702605 | pexidartinib-resistant FLT3 mutants | 1.393706e-02 | 1.856 |
| R-HSA-9674401 | Sunitinib-resistant PDGFR mutants | 1.393706e-02 | 1.856 |
| R-HSA-9702624 | sorafenib-resistant FLT3 mutants | 1.393706e-02 | 1.856 |
| R-HSA-9702614 | ponatinib-resistant FLT3 mutants | 1.393706e-02 | 1.856 |
| R-HSA-9669924 | Masitinib-resistant KIT mutants | 1.393706e-02 | 1.856 |
| R-HSA-9669936 | Sorafenib-resistant KIT mutants | 1.393706e-02 | 1.856 |
| R-HSA-9674396 | Imatinib-resistant PDGFR mutants | 1.393706e-02 | 1.856 |
| R-HSA-9702596 | lestaurtinib-resistant FLT3 mutants | 1.393706e-02 | 1.856 |
| R-HSA-9702998 | linifanib-resistant FLT3 mutants | 1.393706e-02 | 1.856 |
| R-HSA-9669929 | Regorafenib-resistant KIT mutants | 1.393706e-02 | 1.856 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 1.249114e-02 | 1.903 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 1.352989e-02 | 1.869 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 1.264170e-02 | 1.898 |
| R-HSA-418889 | Caspase activation via Dependence Receptors in the absence of ligand | 1.264170e-02 | 1.898 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 1.264170e-02 | 1.898 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 1.274053e-02 | 1.895 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 1.265823e-02 | 1.898 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 1.294146e-02 | 1.888 |
| R-HSA-83936 | Transport of nucleosides and free purine and pyrimidine bases across the plasma ... | 1.164080e-02 | 1.934 |
| R-HSA-8851680 | Butyrophilin (BTN) family interactions | 1.264170e-02 | 1.898 |
| R-HSA-1266738 | Developmental Biology | 1.043793e-02 | 1.981 |
| R-HSA-451308 | Activation of Ca-permeable Kainate Receptor | 1.470141e-02 | 1.833 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 1.637775e-02 | 1.786 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 1.466829e-02 | 1.834 |
| R-HSA-379724 | tRNA Aminoacylation | 1.607529e-02 | 1.794 |
| R-HSA-983189 | Kinesins | 1.607529e-02 | 1.794 |
| R-HSA-451306 | Ionotropic activity of kainate receptors | 1.689515e-02 | 1.772 |
| R-HSA-186797 | Signaling by PDGF | 1.766988e-02 | 1.753 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 1.795960e-02 | 1.746 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 1.808123e-02 | 1.743 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 1.850281e-02 | 1.733 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 1.850281e-02 | 1.733 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 2.166844e-02 | 1.664 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 1.931186e-02 | 1.714 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 2.114626e-02 | 1.675 |
| R-HSA-418594 | G alpha (i) signalling events | 1.874971e-02 | 1.727 |
| R-HSA-422356 | Regulation of insulin secretion | 1.959906e-02 | 1.708 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 1.896877e-02 | 1.722 |
| R-HSA-418359 | Reduction of cytosolic Ca++ levels | 1.921884e-02 | 1.716 |
| R-HSA-112316 | Neuronal System | 2.170895e-02 | 1.663 |
| R-HSA-2262752 | Cellular responses to stress | 2.109598e-02 | 1.676 |
| R-HSA-5610787 | Hedgehog 'off' state | 2.099601e-02 | 1.678 |
| R-HSA-449147 | Signaling by Interleukins | 2.095163e-02 | 1.679 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 2.376934e-02 | 1.624 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 2.398124e-02 | 1.620 |
| R-HSA-112315 | Transmission across Chemical Synapses | 2.418612e-02 | 1.616 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 2.424004e-02 | 1.615 |
| R-HSA-170968 | Frs2-mediated activation | 2.424004e-02 | 1.615 |
| R-HSA-162906 | HIV Infection | 2.446093e-02 | 1.612 |
| R-HSA-211728 | Regulation of PAK-2p34 activity by PS-GAP/RHG10 | 2.768072e-02 | 1.558 |
| R-HSA-1433559 | Regulation of KIT signaling | 2.692978e-02 | 1.570 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 2.764687e-02 | 1.558 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 2.919435e-02 | 1.535 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 2.817759e-02 | 1.550 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 2.808065e-02 | 1.552 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 2.973391e-02 | 1.527 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 2.808065e-02 | 1.552 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 2.709798e-02 | 1.567 |
| R-HSA-9646399 | Aggrephagy | 2.919435e-02 | 1.535 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 2.764687e-02 | 1.558 |
| R-HSA-5617833 | Cilium Assembly | 2.931603e-02 | 1.533 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 2.919435e-02 | 1.535 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 2.614451e-02 | 1.583 |
| R-HSA-3000178 | ECM proteoglycans | 2.604359e-02 | 1.584 |
| R-HSA-9013694 | Signaling by NOTCH4 | 2.928252e-02 | 1.533 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 2.973391e-02 | 1.527 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 2.501433e-02 | 1.602 |
| R-HSA-1643685 | Disease | 2.587293e-02 | 1.587 |
| R-HSA-380287 | Centrosome maturation | 3.041286e-02 | 1.517 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 3.078683e-02 | 1.512 |
| R-HSA-169893 | Prolonged ERK activation events | 3.264875e-02 | 1.486 |
| R-HSA-165159 | MTOR signalling | 3.410620e-02 | 1.467 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 3.567069e-02 | 1.448 |
| R-HSA-9669935 | Signaling by juxtamembrane domain KIT mutants | 4.123366e-02 | 1.385 |
| R-HSA-9680187 | Signaling by extracellular domain mutants of KIT | 4.123366e-02 | 1.385 |
| R-HSA-9669933 | Signaling by kinase domain mutants of KIT | 4.123366e-02 | 1.385 |
| R-HSA-5602636 | IKBKB deficiency causes SCID | 4.123366e-02 | 1.385 |
| R-HSA-5603027 | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... | 4.123366e-02 | 1.385 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 4.453790e-02 | 1.351 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 4.453790e-02 | 1.351 |
| R-HSA-3371556 | Cellular response to heat stress | 4.293538e-02 | 1.367 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 3.754906e-02 | 1.425 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 3.754906e-02 | 1.425 |
| R-HSA-75153 | Apoptotic execution phase | 4.127700e-02 | 1.384 |
| R-HSA-392851 | Prostacyclin signalling through prostacyclin receptor | 4.534429e-02 | 1.343 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 3.879621e-02 | 1.411 |
| R-HSA-164378 | PKA activation in glucagon signalling | 4.202187e-02 | 1.377 |
| R-HSA-437239 | Recycling pathway of L1 | 4.317915e-02 | 1.365 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 4.071755e-02 | 1.390 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 3.644782e-02 | 1.438 |
| R-HSA-190828 | Gap junction trafficking | 3.760352e-02 | 1.425 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 4.202187e-02 | 1.377 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 4.173820e-02 | 1.379 |
| R-HSA-2132295 | MHC class II antigen presentation | 4.521359e-02 | 1.345 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 3.941836e-02 | 1.404 |
| R-HSA-392517 | Rap1 signalling | 4.534429e-02 | 1.343 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 4.521359e-02 | 1.345 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 4.202187e-02 | 1.377 |
| R-HSA-2467813 | Separation of Sister Chromatids | 4.476983e-02 | 1.349 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 4.202187e-02 | 1.377 |
| R-HSA-2408522 | Selenoamino acid metabolism | 4.476983e-02 | 1.349 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 4.202187e-02 | 1.377 |
| R-HSA-9833482 | PKR-mediated signaling | 3.644782e-02 | 1.438 |
| R-HSA-157858 | Gap junction trafficking and regulation | 4.711282e-02 | 1.327 |
| R-HSA-438064 | Post NMDA receptor activation events | 4.744050e-02 | 1.324 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 4.876018e-02 | 1.312 |
| R-HSA-9629569 | Protein hydroxylation | 4.876018e-02 | 1.312 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 5.459851e-02 | 1.263 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 5.459851e-02 | 1.263 |
| R-HSA-68881 | Mitotic Metaphase/Anaphase Transition | 5.459851e-02 | 1.263 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 5.459851e-02 | 1.263 |
| R-HSA-3814836 | Glycogen storage disease type XV (GYG1) | 5.459851e-02 | 1.263 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 5.459851e-02 | 1.263 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 5.459851e-02 | 1.263 |
| R-HSA-5357609 | Glycogen storage disease type II (GAA) | 5.459851e-02 | 1.263 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 5.459851e-02 | 1.263 |
| R-HSA-3828062 | Glycogen storage disease type 0 (muscle GYS1) | 5.459851e-02 | 1.263 |
| R-HSA-3656535 | TGFBR1 LBD Mutants in Cancer | 5.459851e-02 | 1.263 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 5.459851e-02 | 1.263 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 5.459851e-02 | 1.263 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 5.459851e-02 | 1.263 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 5.459851e-02 | 1.263 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 5.459851e-02 | 1.263 |
| R-HSA-202040 | G-protein activation | 5.226630e-02 | 1.282 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 5.585952e-02 | 1.253 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 5.585952e-02 | 1.253 |
| R-HSA-9669938 | Signaling by KIT in disease | 5.953674e-02 | 1.225 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 5.953674e-02 | 1.225 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 5.953674e-02 | 1.225 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 6.329494e-02 | 1.199 |
| R-HSA-72649 | Translation initiation complex formation | 5.768589e-02 | 1.239 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 6.220283e-02 | 1.206 |
| R-HSA-446343 | Localization of the PINCH-ILK-PARVIN complex to focal adhesions | 5.459851e-02 | 1.263 |
| R-HSA-168277 | Influenza Virus Induced Apoptosis | 5.459851e-02 | 1.263 |
| R-HSA-194306 | Neurophilin interactions with VEGF and VEGFR | 5.459851e-02 | 1.263 |
| R-HSA-418555 | G alpha (s) signalling events | 5.300408e-02 | 1.276 |
| R-HSA-114608 | Platelet degranulation | 5.122030e-02 | 1.291 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 6.037892e-02 | 1.219 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 6.600440e-02 | 1.180 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 5.585952e-02 | 1.253 |
| R-HSA-163685 | Integration of energy metabolism | 6.600440e-02 | 1.180 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 5.226630e-02 | 1.282 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 5.503835e-02 | 1.259 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 5.138107e-02 | 1.289 |
| R-HSA-168255 | Influenza Infection | 6.210354e-02 | 1.207 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 6.329494e-02 | 1.199 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 6.220283e-02 | 1.206 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 5.901702e-02 | 1.229 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 5.519749e-02 | 1.258 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 5.519749e-02 | 1.258 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 6.329494e-02 | 1.199 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 5.744514e-02 | 1.241 |
| R-HSA-9755088 | Ribavirin ADME | 5.585952e-02 | 1.253 |
| R-HSA-913531 | Interferon Signaling | 6.064832e-02 | 1.217 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 6.687925e-02 | 1.175 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 6.713118e-02 | 1.173 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 6.777787e-02 | 1.169 |
| R-HSA-5660862 | Defective SLC7A7 causes lysinuric protein intolerance (LPI) | 6.777787e-02 | 1.169 |
| R-HSA-5682113 | Defective ABCA1 causes TGD | 6.777787e-02 | 1.169 |
| R-HSA-9960525 | CASP5-mediated substrate cleavage | 6.777787e-02 | 1.169 |
| R-HSA-9960519 | CASP4-mediated substrate cleavage | 6.777787e-02 | 1.169 |
| R-HSA-5358351 | Signaling by Hedgehog | 6.892354e-02 | 1.162 |
| R-HSA-194441 | Metabolism of non-coding RNA | 6.927616e-02 | 1.159 |
| R-HSA-191859 | snRNP Assembly | 6.927616e-02 | 1.159 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 6.927616e-02 | 1.159 |
| R-HSA-69275 | G2/M Transition | 7.077962e-02 | 1.150 |
| R-HSA-3000157 | Laminin interactions | 7.104258e-02 | 1.148 |
| R-HSA-9620244 | Long-term potentiation | 7.104258e-02 | 1.148 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 7.244853e-02 | 1.140 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 7.338083e-02 | 1.134 |
| R-HSA-445717 | Aquaporin-mediated transport | 7.418509e-02 | 1.130 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 7.431484e-02 | 1.129 |
| R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | 7.502631e-02 | 1.125 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 7.502631e-02 | 1.125 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 7.502631e-02 | 1.125 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 7.620539e-02 | 1.118 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 7.620539e-02 | 1.118 |
| R-HSA-1268020 | Mitochondrial protein import | 7.669616e-02 | 1.115 |
| R-HSA-6784531 | tRNA processing in the nucleus | 7.669616e-02 | 1.115 |
| R-HSA-211163 | AKT-mediated inactivation of FOXO1A | 8.077431e-02 | 1.093 |
| R-HSA-1251932 | PLCG1 events in ERBB2 signaling | 8.077431e-02 | 1.093 |
| R-HSA-1306955 | GRB7 events in ERBB2 signaling | 8.077431e-02 | 1.093 |
| R-HSA-5579024 | Defective MAT1A causes MATD | 8.077431e-02 | 1.093 |
| R-HSA-8866376 | Reelin signalling pathway | 9.359035e-02 | 1.029 |
| R-HSA-9706377 | FLT3 signaling by CBL mutants | 9.359035e-02 | 1.029 |
| R-HSA-176417 | Phosphorylation of Emi1 | 1.062285e-01 | 0.974 |
| R-HSA-9652817 | Signaling by MAPK mutants | 1.062285e-01 | 0.974 |
| R-HSA-8964011 | HDL clearance | 1.186912e-01 | 0.926 |
| R-HSA-9645135 | STAT5 Activation | 1.186912e-01 | 0.926 |
| R-HSA-447041 | CHL1 interactions | 1.309808e-01 | 0.883 |
| R-HSA-111367 | SLBP independent Processing of Histone Pre-mRNAs | 1.309808e-01 | 0.883 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 1.309808e-01 | 0.883 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 1.430999e-01 | 0.844 |
| R-HSA-446107 | Type I hemidesmosome assembly | 1.430999e-01 | 0.844 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 1.430999e-01 | 0.844 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 1.430999e-01 | 0.844 |
| R-HSA-196025 | Formation of annular gap junctions | 1.430999e-01 | 0.844 |
| R-HSA-3785653 | Myoclonic epilepsy of Lafora | 1.430999e-01 | 0.844 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 1.430999e-01 | 0.844 |
| R-HSA-201688 | WNT mediated activation of DVL | 1.550507e-01 | 0.810 |
| R-HSA-190873 | Gap junction degradation | 1.550507e-01 | 0.810 |
| R-HSA-9700645 | ALK mutants bind TKIs | 1.550507e-01 | 0.810 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 1.899165e-01 | 0.721 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 2.012171e-01 | 0.696 |
| R-HSA-3656237 | Defective EXT2 causes exostoses 2 | 2.012171e-01 | 0.696 |
| R-HSA-3656253 | Defective EXT1 causes exostoses 1, TRPS2 and CHDS | 2.012171e-01 | 0.696 |
| R-HSA-170660 | Adenylate cyclase activating pathway | 2.123608e-01 | 0.673 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 9.163043e-02 | 1.038 |
| R-HSA-177504 | Retrograde neurotrophin signalling | 2.233497e-01 | 0.651 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 2.233497e-01 | 0.651 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 9.593574e-02 | 1.018 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 9.593574e-02 | 1.018 |
| R-HSA-9027284 | Erythropoietin activates RAS | 2.341859e-01 | 0.630 |
| R-HSA-9673770 | Signaling by PDGFRA extracellular domain mutants | 2.341859e-01 | 0.630 |
| R-HSA-9673767 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 2.341859e-01 | 0.630 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 2.341859e-01 | 0.630 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 1.047141e-01 | 0.980 |
| R-HSA-9706369 | Negative regulation of FLT3 | 2.448716e-01 | 0.611 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 2.448716e-01 | 0.611 |
| R-HSA-168275 | Entry of Influenza Virion into Host Cell via Endocytosis | 2.448716e-01 | 0.611 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 1.182658e-01 | 0.927 |
| R-HSA-3371511 | HSF1 activation | 1.228765e-01 | 0.911 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 1.760057e-01 | 0.754 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 1.810068e-01 | 0.742 |
| R-HSA-3371571 | HSF1-dependent transactivation | 2.012074e-01 | 0.696 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 2.345885e-01 | 0.630 |
| R-HSA-186763 | Downstream signal transduction | 9.593574e-02 | 1.018 |
| R-HSA-1433557 | Signaling by SCF-KIT | 1.611457e-01 | 0.793 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 1.340129e-01 | 0.873 |
| R-HSA-9607240 | FLT3 Signaling | 1.465359e-01 | 0.834 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 1.513751e-01 | 0.820 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 1.760057e-01 | 0.754 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 1.760057e-01 | 0.754 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 1.436257e-01 | 0.843 |
| R-HSA-6802949 | Signaling by RAS mutants | 1.760057e-01 | 0.754 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 1.002978e-01 | 0.999 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 1.899165e-01 | 0.721 |
| R-HSA-75205 | Dissolution of Fibrin Clot | 1.784567e-01 | 0.748 |
| R-HSA-77588 | SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs | 1.430999e-01 | 0.844 |
| R-HSA-2025928 | Calcineurin activates NFAT | 1.550507e-01 | 0.810 |
| R-HSA-8963901 | Chylomicron remodeling | 2.123608e-01 | 0.673 |
| R-HSA-8963896 | HDL assembly | 2.233497e-01 | 0.651 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 9.593574e-02 | 1.018 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 1.091824e-01 | 0.962 |
| R-HSA-9664420 | Killing mechanisms | 2.448716e-01 | 0.611 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 2.448716e-01 | 0.611 |
| R-HSA-434316 | Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion | 2.448716e-01 | 0.611 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 1.275304e-01 | 0.894 |
| R-HSA-5674135 | MAP2K and MAPK activation | 1.513751e-01 | 0.820 |
| R-HSA-8963888 | Chylomicron assembly | 1.784567e-01 | 0.748 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 2.114048e-01 | 0.675 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 2.448716e-01 | 0.611 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 2.126308e-01 | 0.672 |
| R-HSA-389356 | Co-stimulation by CD28 | 1.860290e-01 | 0.730 |
| R-HSA-3656534 | Loss of Function of TGFBR1 in Cancer | 9.359035e-02 | 1.029 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 1.062285e-01 | 0.974 |
| R-HSA-111459 | Activation of caspases through apoptosome-mediated cleavage | 1.062285e-01 | 0.974 |
| R-HSA-418886 | Netrin mediated repulsion signals | 1.309808e-01 | 0.883 |
| R-HSA-162791 | Attachment of GPI anchor to uPAR | 1.309808e-01 | 0.883 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 1.309808e-01 | 0.883 |
| R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 1.668355e-01 | 0.778 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 8.738429e-02 | 1.059 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 2.341859e-01 | 0.630 |
| R-HSA-2485179 | Activation of the phototransduction cascade | 2.448716e-01 | 0.611 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 1.137004e-01 | 0.944 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 1.228765e-01 | 0.911 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 1.275304e-01 | 0.894 |
| R-HSA-6811438 | Intra-Golgi traffic | 1.513751e-01 | 0.820 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 1.562456e-01 | 0.806 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 1.710274e-01 | 0.767 |
| R-HSA-5620924 | Intraflagellar transport | 1.860290e-01 | 0.730 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 1.911629e-01 | 0.719 |
| R-HSA-5260271 | Diseases of Immune System | 1.417300e-01 | 0.849 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 1.417300e-01 | 0.849 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 1.037630e-01 | 0.984 |
| R-HSA-72766 | Translation | 1.043213e-01 | 0.982 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 9.010537e-02 | 1.045 |
| R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 1.309808e-01 | 0.883 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 1.668355e-01 | 0.778 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 2.233497e-01 | 0.651 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 2.341859e-01 | 0.630 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 1.091824e-01 | 0.962 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 2.448716e-01 | 0.611 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 1.737295e-01 | 0.760 |
| R-HSA-391251 | Protein folding | 1.737295e-01 | 0.760 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 2.060125e-01 | 0.686 |
| R-HSA-4086400 | PCP/CE pathway | 1.215662e-01 | 0.915 |
| R-HSA-111464 | SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes | 9.359035e-02 | 1.029 |
| R-HSA-8964046 | VLDL clearance | 1.309808e-01 | 0.883 |
| R-HSA-444473 | Formyl peptide receptors bind formyl peptides and many other ligands | 1.430999e-01 | 0.844 |
| R-HSA-170984 | ARMS-mediated activation | 1.550507e-01 | 0.810 |
| R-HSA-71032 | Propionyl-CoA catabolism | 1.784567e-01 | 0.748 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 2.012171e-01 | 0.696 |
| R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 8.319983e-02 | 1.080 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 8.319983e-02 | 1.080 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 2.341859e-01 | 0.630 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 2.341859e-01 | 0.630 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 2.341859e-01 | 0.630 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 1.417300e-01 | 0.849 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 1.710274e-01 | 0.767 |
| R-HSA-9609690 | HCMV Early Events | 1.865551e-01 | 0.729 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 2.272217e-01 | 0.644 |
| R-HSA-187687 | Signalling to ERKs | 1.182658e-01 | 0.927 |
| R-HSA-445355 | Smooth Muscle Contraction | 2.114048e-01 | 0.675 |
| R-HSA-111469 | SMAC, XIAP-regulated apoptotic response | 1.062285e-01 | 0.974 |
| R-HSA-9837999 | Mitochondrial protein degradation | 1.806482e-01 | 0.743 |
| R-HSA-8953854 | Metabolism of RNA | 9.609810e-02 | 1.017 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 2.233497e-01 | 0.651 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 1.047141e-01 | 0.980 |
| R-HSA-180746 | Nuclear import of Rev protein | 1.137004e-01 | 0.944 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 2.216519e-01 | 0.654 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 2.264942e-01 | 0.645 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 9.593574e-02 | 1.018 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 1.760057e-01 | 0.754 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 1.534596e-01 | 0.814 |
| R-HSA-111463 | SMAC (DIABLO) binds to IAPs | 9.359035e-02 | 1.029 |
| R-HSA-5576890 | Phase 3 - rapid repolarisation | 1.309808e-01 | 0.883 |
| R-HSA-3371599 | Defective HLCS causes multiple carboxylase deficiency | 1.309808e-01 | 0.883 |
| R-HSA-198693 | AKT phosphorylates targets in the nucleus | 1.550507e-01 | 0.810 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 1.668355e-01 | 0.778 |
| R-HSA-9683686 | Maturation of spike protein | 1.668355e-01 | 0.778 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 1.899165e-01 | 0.721 |
| R-HSA-428540 | Activation of RAC1 | 1.899165e-01 | 0.721 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 2.012171e-01 | 0.696 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 2.012171e-01 | 0.696 |
| R-HSA-77305 | Beta oxidation of palmitoyl-CoA to myristoyl-CoA | 2.012171e-01 | 0.696 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 2.012171e-01 | 0.696 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 2.233497e-01 | 0.651 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 2.341859e-01 | 0.630 |
| R-HSA-8875878 | MET promotes cell motility | 1.322252e-01 | 0.879 |
| R-HSA-9694548 | Maturation of spike protein | 1.465359e-01 | 0.834 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 1.465359e-01 | 0.834 |
| R-HSA-9609507 | Protein localization | 2.205879e-01 | 0.656 |
| R-HSA-202433 | Generation of second messenger molecules | 1.417300e-01 | 0.849 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 1.513751e-01 | 0.820 |
| R-HSA-5578775 | Ion homeostasis | 2.267908e-01 | 0.644 |
| R-HSA-196780 | Biotin transport and metabolism | 2.341859e-01 | 0.630 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 1.436257e-01 | 0.843 |
| R-HSA-1474244 | Extracellular matrix organization | 2.253828e-01 | 0.647 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 2.034315e-01 | 0.692 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 1.062285e-01 | 0.974 |
| R-HSA-167590 | Nef Mediated CD4 Down-regulation | 1.309808e-01 | 0.883 |
| R-HSA-9013700 | NOTCH4 Activation and Transmission of Signal to the Nucleus | 1.550507e-01 | 0.810 |
| R-HSA-9754560 | SARS-CoV-2 modulates autophagy | 1.784567e-01 | 0.748 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 1.784567e-01 | 0.748 |
| R-HSA-8851805 | MET activates RAS signaling | 2.012171e-01 | 0.696 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 2.123608e-01 | 0.673 |
| R-HSA-391160 | Signal regulatory protein family interactions | 2.233497e-01 | 0.651 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 2.448716e-01 | 0.611 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 1.760057e-01 | 0.754 |
| R-HSA-1296071 | Potassium Channels | 1.911629e-01 | 0.719 |
| R-HSA-194138 | Signaling by VEGF | 1.357867e-01 | 0.867 |
| R-HSA-397014 | Muscle contraction | 2.284544e-01 | 0.641 |
| R-HSA-190861 | Gap junction assembly | 1.137004e-01 | 0.944 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 1.066538e-01 | 0.972 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 1.125287e-01 | 0.949 |
| R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 1.062285e-01 | 0.974 |
| R-HSA-3323169 | Defects in biotin (Btn) metabolism | 1.550507e-01 | 0.810 |
| R-HSA-1247673 | Erythrocytes take up oxygen and release carbon dioxide | 2.012171e-01 | 0.696 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 1.369591e-01 | 0.863 |
| R-HSA-68882 | Mitotic Anaphase | 1.170795e-01 | 0.932 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 1.465359e-01 | 0.834 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 2.319382e-01 | 0.635 |
| R-HSA-9612973 | Autophagy | 1.001193e-01 | 0.999 |
| R-HSA-216083 | Integrin cell surface interactions | 1.215662e-01 | 0.915 |
| R-HSA-74160 | Gene expression (Transcription) | 2.314621e-01 | 0.636 |
| R-HSA-3304351 | Signaling by TGF-beta Receptor Complex in Cancer | 1.186912e-01 | 0.926 |
| R-HSA-210990 | PECAM1 interactions | 1.784567e-01 | 0.748 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 1.047141e-01 | 0.980 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 1.009041e-01 | 0.996 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 8.310206e-02 | 1.080 |
| R-HSA-168256 | Immune System | 1.348856e-01 | 0.870 |
| R-HSA-418346 | Platelet homeostasis | 8.601657e-02 | 1.065 |
| R-HSA-418360 | Platelet calcium homeostasis | 8.738429e-02 | 1.059 |
| R-HSA-420092 | Glucagon-type ligand receptors | 8.738429e-02 | 1.059 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 1.277348e-01 | 0.894 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 2.319382e-01 | 0.635 |
| R-HSA-9686114 | Non-canonical inflammasome activation | 2.233497e-01 | 0.651 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 2.448716e-01 | 0.611 |
| R-HSA-9824443 | Parasitic Infection Pathways | 1.334000e-01 | 0.875 |
| R-HSA-9658195 | Leishmania infection | 1.334000e-01 | 0.875 |
| R-HSA-8939211 | ESR-mediated signaling | 1.552787e-01 | 0.809 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 2.012171e-01 | 0.696 |
| R-HSA-9748787 | Azathioprine ADME | 1.961308e-01 | 0.707 |
| R-HSA-9663891 | Selective autophagy | 1.567840e-01 | 0.805 |
| R-HSA-166187 | Mitochondrial Uncoupling | 2.448716e-01 | 0.611 |
| R-HSA-6806834 | Signaling by MET | 1.277348e-01 | 0.894 |
| R-HSA-425397 | Transport of vitamins, nucleosides, and related molecules | 1.095758e-01 | 0.960 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 1.037630e-01 | 0.984 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 1.182658e-01 | 0.927 |
| R-HSA-111461 | Cytochrome c-mediated apoptotic response | 1.899165e-01 | 0.721 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 2.370930e-01 | 0.625 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 8.960235e-02 | 1.048 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 1.562456e-01 | 0.806 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 2.422538e-01 | 0.616 |
| R-HSA-1632852 | Macroautophagy | 1.833275e-01 | 0.737 |
| R-HSA-69205 | G1/S-Specific Transcription | 1.228765e-01 | 0.911 |
| R-HSA-8983711 | OAS antiviral response | 2.012171e-01 | 0.696 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 2.018286e-01 | 0.695 |
| R-HSA-73887 | Death Receptor Signaling | 2.235359e-01 | 0.651 |
| R-HSA-9020558 | Interleukin-2 signaling | 1.784567e-01 | 0.748 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 1.569972e-01 | 0.804 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 2.450230e-01 | 0.611 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 2.457165e-01 | 0.610 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 2.457165e-01 | 0.610 |
| R-HSA-202403 | TCR signaling | 2.457165e-01 | 0.610 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 2.481187e-01 | 0.605 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 2.525892e-01 | 0.598 |
| R-HSA-450294 | MAP kinase activation | 2.525892e-01 | 0.598 |
| R-HSA-1483249 | Inositol phosphate metabolism | 2.531814e-01 | 0.597 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 2.554089e-01 | 0.593 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 2.554089e-01 | 0.593 |
| R-HSA-3560783 | Defective B4GALT7 causes EDS, progeroid type | 2.554089e-01 | 0.593 |
| R-HSA-4420332 | Defective B3GALT6 causes EDSP2 and SEMDJL1 | 2.554089e-01 | 0.593 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 2.554089e-01 | 0.593 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 2.554089e-01 | 0.593 |
| R-HSA-3000471 | Scavenging by Class B Receptors | 2.554089e-01 | 0.593 |
| R-HSA-399997 | Acetylcholine regulates insulin secretion | 2.554089e-01 | 0.593 |
| R-HSA-9927020 | Heme assimilation | 2.554089e-01 | 0.593 |
| R-HSA-5576893 | Phase 2 - plateau phase | 2.554089e-01 | 0.593 |
| R-HSA-9702518 | STAT5 activation downstream of FLT3 ITD mutants | 2.554089e-01 | 0.593 |
| R-HSA-432047 | Passive transport by Aquaporins | 2.554089e-01 | 0.593 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 2.577615e-01 | 0.589 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 2.577615e-01 | 0.589 |
| R-HSA-9707616 | Heme signaling | 2.577615e-01 | 0.589 |
| R-HSA-392499 | Metabolism of proteins | 2.597910e-01 | 0.585 |
| R-HSA-373755 | Semaphorin interactions | 2.629355e-01 | 0.580 |
| R-HSA-8848021 | Signaling by PTK6 | 2.629355e-01 | 0.580 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 2.629355e-01 | 0.580 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 2.644386e-01 | 0.578 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 2.657997e-01 | 0.575 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 2.657997e-01 | 0.575 |
| R-HSA-3560801 | Defective B3GAT3 causes JDSSDHD | 2.657997e-01 | 0.575 |
| R-HSA-3229121 | Glycogen storage diseases | 2.657997e-01 | 0.575 |
| R-HSA-1614517 | Sulfide oxidation to sulfate | 2.657997e-01 | 0.575 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 2.657997e-01 | 0.575 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 2.657997e-01 | 0.575 |
| R-HSA-5210891 | Uptake and function of anthrax toxins | 2.657997e-01 | 0.575 |
| R-HSA-936837 | Ion transport by P-type ATPases | 2.681100e-01 | 0.572 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 2.732841e-01 | 0.563 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 2.732841e-01 | 0.563 |
| R-HSA-72306 | tRNA processing | 2.750218e-01 | 0.561 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 2.760462e-01 | 0.559 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 2.760462e-01 | 0.559 |
| R-HSA-156711 | Polo-like kinase mediated events | 2.760462e-01 | 0.559 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 2.760462e-01 | 0.559 |
| R-HSA-3928664 | Ephrin signaling | 2.760462e-01 | 0.559 |
| R-HSA-111471 | Apoptotic factor-mediated response | 2.760462e-01 | 0.559 |
| R-HSA-180292 | GAB1 signalosome | 2.760462e-01 | 0.559 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 2.760462e-01 | 0.559 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 2.760462e-01 | 0.559 |
| R-HSA-8964058 | HDL remodeling | 2.861503e-01 | 0.543 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 2.861503e-01 | 0.543 |
| R-HSA-1237044 | Erythrocytes take up carbon dioxide and release oxygen | 2.861503e-01 | 0.543 |
| R-HSA-1480926 | O2/CO2 exchange in erythrocytes | 2.861503e-01 | 0.543 |
| R-HSA-912631 | Regulation of signaling by CBL | 2.861503e-01 | 0.543 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 2.861503e-01 | 0.543 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 2.861503e-01 | 0.543 |
| R-HSA-212436 | Generic Transcription Pathway | 2.863527e-01 | 0.543 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 2.871228e-01 | 0.542 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 2.871228e-01 | 0.542 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 2.887940e-01 | 0.539 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 2.887940e-01 | 0.539 |
| R-HSA-195721 | Signaling by WNT | 2.898439e-01 | 0.538 |
| R-HSA-68875 | Mitotic Prophase | 2.909203e-01 | 0.536 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 2.961141e-01 | 0.529 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 2.961141e-01 | 0.529 |
| R-HSA-3322077 | Glycogen synthesis | 2.961141e-01 | 0.529 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 2.961141e-01 | 0.529 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 2.961141e-01 | 0.529 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 2.961141e-01 | 0.529 |
| R-HSA-1362409 | Mitochondrial iron-sulfur cluster biogenesis | 2.961141e-01 | 0.529 |
| R-HSA-445144 | Signal transduction by L1 | 2.961141e-01 | 0.529 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 2.985259e-01 | 0.525 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 2.985259e-01 | 0.525 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 2.991143e-01 | 0.524 |
| R-HSA-448424 | Interleukin-17 signaling | 2.991143e-01 | 0.524 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 3.023331e-01 | 0.520 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 3.042660e-01 | 0.517 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 3.042660e-01 | 0.517 |
| R-HSA-975634 | Retinoid metabolism and transport | 3.042660e-01 | 0.517 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 3.059393e-01 | 0.514 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 3.059393e-01 | 0.514 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 3.059393e-01 | 0.514 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 3.059393e-01 | 0.514 |
| R-HSA-210991 | Basigin interactions | 3.059393e-01 | 0.514 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 3.094109e-01 | 0.509 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 3.094109e-01 | 0.509 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 3.145481e-01 | 0.502 |
| R-HSA-4086398 | Ca2+ pathway | 3.145481e-01 | 0.502 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 3.156280e-01 | 0.501 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 3.156280e-01 | 0.501 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 3.156280e-01 | 0.501 |
| R-HSA-9694614 | Attachment and Entry | 3.156280e-01 | 0.501 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 3.247967e-01 | 0.488 |
| R-HSA-8964038 | LDL clearance | 3.251820e-01 | 0.488 |
| R-HSA-975578 | Reactions specific to the complex N-glycan synthesis pathway | 3.251820e-01 | 0.488 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 3.251820e-01 | 0.488 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 3.251820e-01 | 0.488 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 3.251820e-01 | 0.488 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 3.251820e-01 | 0.488 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 3.252128e-01 | 0.488 |
| R-HSA-388396 | GPCR downstream signalling | 3.262418e-01 | 0.486 |
| R-HSA-9609646 | HCMV Infection | 3.297359e-01 | 0.482 |
| R-HSA-9020591 | Interleukin-12 signaling | 3.299065e-01 | 0.482 |
| R-HSA-1280218 | Adaptive Immune System | 3.300111e-01 | 0.481 |
| R-HSA-382551 | Transport of small molecules | 3.337840e-01 | 0.477 |
| R-HSA-983712 | Ion channel transport | 3.345527e-01 | 0.476 |
| R-HSA-400451 | Free fatty acids regulate insulin secretion | 3.346033e-01 | 0.475 |
| R-HSA-879518 | Organic anion transport by SLCO transporters | 3.346033e-01 | 0.475 |
| R-HSA-1369062 | ABC transporters in lipid homeostasis | 3.346033e-01 | 0.475 |
| R-HSA-9694635 | Translation of Structural Proteins | 3.350058e-01 | 0.475 |
| R-HSA-6783783 | Interleukin-10 signaling | 3.400937e-01 | 0.468 |
| R-HSA-5576891 | Cardiac conduction | 3.404722e-01 | 0.468 |
| R-HSA-168898 | Toll-like Receptor Cascades | 3.408768e-01 | 0.467 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 3.438936e-01 | 0.464 |
| R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse | 3.438936e-01 | 0.464 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 3.438936e-01 | 0.464 |
| R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 3.438936e-01 | 0.464 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 3.438936e-01 | 0.464 |
| R-HSA-8963898 | Plasma lipoprotein assembly | 3.438936e-01 | 0.464 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 3.438936e-01 | 0.464 |
| R-HSA-428930 | Thromboxane signalling through TP receptor | 3.438936e-01 | 0.464 |
| R-HSA-9865881 | Complex III assembly | 3.438936e-01 | 0.464 |
| R-HSA-9836573 | Mitochondrial RNA degradation | 3.438936e-01 | 0.464 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 3.438936e-01 | 0.464 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 3.438936e-01 | 0.464 |
| R-HSA-8863678 | Neurodegenerative Diseases | 3.438936e-01 | 0.464 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 3.440404e-01 | 0.463 |
| R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 3.530547e-01 | 0.452 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 3.530547e-01 | 0.452 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 3.530547e-01 | 0.452 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 3.530547e-01 | 0.452 |
| R-HSA-6806667 | Metabolism of fat-soluble vitamins | 3.552829e-01 | 0.449 |
| R-HSA-977225 | Amyloid fiber formation | 3.552829e-01 | 0.449 |
| R-HSA-6798695 | Neutrophil degranulation | 3.572840e-01 | 0.447 |
| R-HSA-3295583 | TRP channels | 3.620885e-01 | 0.441 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 3.620885e-01 | 0.441 |
| R-HSA-8874081 | MET activates PTK2 signaling | 3.620885e-01 | 0.441 |
| R-HSA-9638630 | Attachment of bacteria to epithelial cells | 3.620885e-01 | 0.441 |
| R-HSA-9734767 | Developmental Cell Lineages | 3.656010e-01 | 0.437 |
| R-HSA-73857 | RNA Polymerase II Transcription | 3.692160e-01 | 0.433 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 3.709967e-01 | 0.431 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 3.709967e-01 | 0.431 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 3.709967e-01 | 0.431 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 3.709967e-01 | 0.431 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 3.709967e-01 | 0.431 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 3.709967e-01 | 0.431 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 3.709967e-01 | 0.431 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 3.753385e-01 | 0.426 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 3.756851e-01 | 0.425 |
| R-HSA-376176 | Signaling by ROBO receptors | 3.788459e-01 | 0.422 |
| R-HSA-9711123 | Cellular response to chemical stress | 3.794330e-01 | 0.421 |
| R-HSA-5620971 | Pyroptosis | 3.797810e-01 | 0.420 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 3.852717e-01 | 0.414 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 3.852717e-01 | 0.414 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 3.884432e-01 | 0.411 |
| R-HSA-9615710 | Late endosomal microautophagy | 3.884432e-01 | 0.411 |
| R-HSA-9006335 | Signaling by Erythropoietin | 3.884432e-01 | 0.411 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 3.884432e-01 | 0.411 |
| R-HSA-1592389 | Activation of Matrix Metalloproteinases | 3.884432e-01 | 0.411 |
| R-HSA-204174 | Regulation of pyruvate dehydrogenase (PDH) complex | 3.884432e-01 | 0.411 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 3.897977e-01 | 0.409 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 3.897977e-01 | 0.409 |
| R-HSA-70268 | Pyruvate metabolism | 3.902128e-01 | 0.409 |
| R-HSA-447115 | Interleukin-12 family signaling | 3.902128e-01 | 0.409 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 3.935613e-01 | 0.405 |
| R-HSA-156902 | Peptide chain elongation | 3.951362e-01 | 0.403 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 3.958334e-01 | 0.402 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 3.969849e-01 | 0.401 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 3.969849e-01 | 0.401 |
| R-HSA-2424491 | DAP12 signaling | 3.969849e-01 | 0.401 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 3.969849e-01 | 0.401 |
| R-HSA-456926 | Thrombin signalling through proteinase activated receptors (PARs) | 3.969849e-01 | 0.401 |
| R-HSA-1236974 | ER-Phagosome pathway | 4.000416e-01 | 0.398 |
| R-HSA-202424 | Downstream TCR signaling | 4.049284e-01 | 0.393 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 4.049284e-01 | 0.393 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 4.054079e-01 | 0.392 |
| R-HSA-399719 | Trafficking of AMPA receptors | 4.054079e-01 | 0.392 |
| R-HSA-5694530 | Cargo concentration in the ER | 4.054079e-01 | 0.392 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 4.054079e-01 | 0.392 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 4.085541e-01 | 0.389 |
| R-HSA-2187338 | Visual phototransduction | 4.085541e-01 | 0.389 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 4.097962e-01 | 0.387 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 4.097962e-01 | 0.387 |
| R-HSA-166520 | Signaling by NTRKs | 4.122855e-01 | 0.385 |
| R-HSA-2024096 | HS-GAG degradation | 4.137137e-01 | 0.383 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 4.146445e-01 | 0.382 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 4.194731e-01 | 0.377 |
| R-HSA-2682334 | EPH-Ephrin signaling | 4.194731e-01 | 0.377 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 4.194731e-01 | 0.377 |
| R-HSA-354192 | Integrin signaling | 4.219040e-01 | 0.375 |
| R-HSA-9930044 | Nuclear RNA decay | 4.219040e-01 | 0.375 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 4.219040e-01 | 0.375 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 4.219040e-01 | 0.375 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 4.219040e-01 | 0.375 |
| R-HSA-1474290 | Collagen formation | 4.290691e-01 | 0.367 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 4.299804e-01 | 0.367 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 4.299804e-01 | 0.367 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 4.299804e-01 | 0.367 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 4.338359e-01 | 0.363 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 4.338359e-01 | 0.363 |
| R-HSA-77289 | Mitochondrial Fatty Acid Beta-Oxidation | 4.338359e-01 | 0.363 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 4.379444e-01 | 0.359 |
| R-HSA-5673000 | RAF activation | 4.379444e-01 | 0.359 |
| R-HSA-1971475 | Glycosaminoglycan-protein linkage region biosynthesis | 4.379444e-01 | 0.359 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 4.379444e-01 | 0.359 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 4.379444e-01 | 0.359 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 4.379444e-01 | 0.359 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 4.379444e-01 | 0.359 |
| R-HSA-1989781 | PPARA activates gene expression | 4.381884e-01 | 0.358 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 4.385814e-01 | 0.358 |
| R-HSA-72764 | Eukaryotic Translation Termination | 4.385814e-01 | 0.358 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 4.385814e-01 | 0.358 |
| R-HSA-2168880 | Scavenging of heme from plasma | 4.385814e-01 | 0.358 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 4.455122e-01 | 0.351 |
| R-HSA-162587 | HIV Life Cycle | 4.455122e-01 | 0.351 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 4.457977e-01 | 0.351 |
| R-HSA-169911 | Regulation of Apoptosis | 4.457977e-01 | 0.351 |
| R-HSA-2559585 | Oncogene Induced Senescence | 4.457977e-01 | 0.351 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 4.457977e-01 | 0.351 |
| R-HSA-2408508 | Metabolism of ingested SeMet, Sec, MeSec into H2Se | 4.457977e-01 | 0.351 |
| R-HSA-3296482 | Defects in vitamin and cofactor metabolism | 4.457977e-01 | 0.351 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 4.503692e-01 | 0.346 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 4.526869e-01 | 0.344 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 4.526869e-01 | 0.344 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 4.526869e-01 | 0.344 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 4.526869e-01 | 0.344 |
| R-HSA-2022928 | HS-GAG biosynthesis | 4.535417e-01 | 0.343 |
| R-HSA-9682385 | FLT3 signaling in disease | 4.535417e-01 | 0.343 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 4.535417e-01 | 0.343 |
| R-HSA-114604 | GPVI-mediated activation cascade | 4.535417e-01 | 0.343 |
| R-HSA-1296072 | Voltage gated Potassium channels | 4.611779e-01 | 0.336 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 4.611779e-01 | 0.336 |
| R-HSA-4641258 | Degradation of DVL | 4.611779e-01 | 0.336 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 4.611779e-01 | 0.336 |
| R-HSA-419037 | NCAM1 interactions | 4.611779e-01 | 0.336 |
| R-HSA-8948216 | Collagen chain trimerization | 4.611779e-01 | 0.336 |
| R-HSA-372790 | Signaling by GPCR | 4.618719e-01 | 0.335 |
| R-HSA-70171 | Glycolysis | 4.619782e-01 | 0.335 |
| R-HSA-2408557 | Selenocysteine synthesis | 4.665894e-01 | 0.331 |
| R-HSA-9931953 | Biofilm formation | 4.687080e-01 | 0.329 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 4.711772e-01 | 0.327 |
| R-HSA-192823 | Viral mRNA Translation | 4.757414e-01 | 0.323 |
| R-HSA-69541 | Stabilization of p53 | 4.761332e-01 | 0.322 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 4.761332e-01 | 0.322 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 4.761332e-01 | 0.322 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 4.802818e-01 | 0.319 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 4.802818e-01 | 0.319 |
| R-HSA-5619102 | SLC transporter disorders | 4.815345e-01 | 0.317 |
| R-HSA-3371568 | Attenuation phase | 4.834551e-01 | 0.316 |
| R-HSA-8982491 | Glycogen metabolism | 4.834551e-01 | 0.316 |
| R-HSA-9854311 | Maturation of TCA enzymes and regulation of TCA cycle | 4.834551e-01 | 0.316 |
| R-HSA-975576 | N-glycan antennae elongation in the medial/trans-Golgi | 4.834551e-01 | 0.316 |
| R-HSA-71240 | Tryptophan catabolism | 4.834551e-01 | 0.316 |
| R-HSA-379726 | Mitochondrial tRNA aminoacylation | 4.834551e-01 | 0.316 |
| R-HSA-451927 | Interleukin-2 family signaling | 4.834551e-01 | 0.316 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 4.847981e-01 | 0.314 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 4.847981e-01 | 0.314 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 4.906752e-01 | 0.309 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 4.906752e-01 | 0.309 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 4.906752e-01 | 0.309 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 4.956362e-01 | 0.305 |
| R-HSA-157118 | Signaling by NOTCH | 4.962663e-01 | 0.304 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 4.977947e-01 | 0.303 |
| R-HSA-3000480 | Scavenging by Class A Receptors | 4.977947e-01 | 0.303 |
| R-HSA-9683701 | Translation of Structural Proteins | 4.977947e-01 | 0.303 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 4.982005e-01 | 0.303 |
| R-HSA-9700206 | Signaling by ALK in cancer | 4.982005e-01 | 0.303 |
| R-HSA-211000 | Gene Silencing by RNA | 4.982005e-01 | 0.303 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 5.026184e-01 | 0.299 |
| R-HSA-2672351 | Stimuli-sensing channels | 5.026184e-01 | 0.299 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 5.026184e-01 | 0.299 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 5.048152e-01 | 0.297 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 5.070114e-01 | 0.295 |
| R-HSA-1500931 | Cell-Cell communication | 5.096730e-01 | 0.293 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 5.117380e-01 | 0.291 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 5.169568e-01 | 0.287 |
| R-HSA-2172127 | DAP12 interactions | 5.185644e-01 | 0.285 |
| R-HSA-373752 | Netrin-1 signaling | 5.185644e-01 | 0.285 |
| R-HSA-156581 | Methylation | 5.185644e-01 | 0.285 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 5.200386e-01 | 0.284 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 5.200386e-01 | 0.284 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 5.200386e-01 | 0.284 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 5.243299e-01 | 0.280 |
| R-HSA-774815 | Nucleosome assembly | 5.252958e-01 | 0.280 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 5.252958e-01 | 0.280 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 5.252958e-01 | 0.280 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 5.252958e-01 | 0.280 |
| R-HSA-3560782 | Diseases associated with glycosaminoglycan metabolism | 5.252958e-01 | 0.280 |
| R-HSA-1614558 | Degradation of cysteine and homocysteine | 5.252958e-01 | 0.280 |
| R-HSA-77286 | mitochondrial fatty acid beta-oxidation of saturated fatty acids | 5.252958e-01 | 0.280 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 5.278582e-01 | 0.277 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 5.319334e-01 | 0.274 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 5.319334e-01 | 0.274 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 5.319334e-01 | 0.274 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 5.319334e-01 | 0.274 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 5.319334e-01 | 0.274 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 5.370488e-01 | 0.270 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 5.384787e-01 | 0.269 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 5.384787e-01 | 0.269 |
| R-HSA-1483191 | Synthesis of PC | 5.384787e-01 | 0.269 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 5.412364e-01 | 0.267 |
| R-HSA-8963899 | Plasma lipoprotein remodeling | 5.449328e-01 | 0.264 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 5.449328e-01 | 0.264 |
| R-HSA-70326 | Glucose metabolism | 5.495331e-01 | 0.260 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 5.512971e-01 | 0.259 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 5.512971e-01 | 0.259 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 5.512971e-01 | 0.259 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 5.565858e-01 | 0.254 |
| R-HSA-109704 | PI3K Cascade | 5.575728e-01 | 0.254 |
| R-HSA-2514856 | The phototransduction cascade | 5.637610e-01 | 0.249 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 5.637610e-01 | 0.249 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 5.698631e-01 | 0.244 |
| R-HSA-6794361 | Neurexins and neuroligins | 5.698631e-01 | 0.244 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 5.698631e-01 | 0.244 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 5.698631e-01 | 0.244 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 5.758802e-01 | 0.240 |
| R-HSA-1221632 | Meiotic synapsis | 5.758802e-01 | 0.240 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 5.759081e-01 | 0.240 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 5.818135e-01 | 0.235 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 5.855571e-01 | 0.232 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 5.855571e-01 | 0.232 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 5.855571e-01 | 0.232 |
| R-HSA-69206 | G1/S Transition | 5.855571e-01 | 0.232 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 5.876642e-01 | 0.231 |
| R-HSA-9753281 | Paracetamol ADME | 5.876642e-01 | 0.231 |
| R-HSA-9012852 | Signaling by NOTCH3 | 5.876642e-01 | 0.231 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 5.934334e-01 | 0.227 |
| R-HSA-193648 | NRAGE signals death through JNK | 5.934334e-01 | 0.227 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 5.934334e-01 | 0.227 |
| R-HSA-75893 | TNF signaling | 5.934334e-01 | 0.227 |
| R-HSA-177929 | Signaling by EGFR | 5.934334e-01 | 0.227 |
| R-HSA-112399 | IRS-mediated signalling | 5.991221e-01 | 0.222 |
| R-HSA-446728 | Cell junction organization | 6.033724e-01 | 0.219 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 6.038918e-01 | 0.219 |
| R-HSA-72172 | mRNA Splicing | 6.099434e-01 | 0.215 |
| R-HSA-1638091 | Heparan sulfate/heparin (HS-GAG) metabolism | 6.102631e-01 | 0.214 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 6.102631e-01 | 0.214 |
| R-HSA-186712 | Regulation of beta-cell development | 6.102631e-01 | 0.214 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 6.157174e-01 | 0.211 |
| R-HSA-1227986 | Signaling by ERBB2 | 6.157174e-01 | 0.211 |
| R-HSA-8873719 | RAB geranylgeranylation | 6.157174e-01 | 0.211 |
| R-HSA-156590 | Glutathione conjugation | 6.157174e-01 | 0.211 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 6.210957e-01 | 0.207 |
| R-HSA-112043 | PLC beta mediated events | 6.210957e-01 | 0.207 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 6.210957e-01 | 0.207 |
| R-HSA-1442490 | Collagen degradation | 6.210957e-01 | 0.207 |
| R-HSA-168249 | Innate Immune System | 6.245053e-01 | 0.204 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 6.263991e-01 | 0.203 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 6.316286e-01 | 0.200 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 6.316286e-01 | 0.200 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 6.337720e-01 | 0.198 |
| R-HSA-2428924 | IGF1R signaling cascade | 6.367852e-01 | 0.196 |
| R-HSA-74751 | Insulin receptor signalling cascade | 6.367852e-01 | 0.196 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 6.367852e-01 | 0.196 |
| R-HSA-9948299 | Ribosome-associated quality control | 6.407898e-01 | 0.193 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 6.418699e-01 | 0.193 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 6.468837e-01 | 0.189 |
| R-HSA-9748784 | Drug ADME | 6.505645e-01 | 0.187 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 6.518277e-01 | 0.186 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 6.567027e-01 | 0.183 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 6.567027e-01 | 0.183 |
| R-HSA-5218859 | Regulated Necrosis | 6.567027e-01 | 0.183 |
| R-HSA-8951664 | Neddylation | 6.588685e-01 | 0.181 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 6.615098e-01 | 0.179 |
| R-HSA-597592 | Post-translational protein modification | 6.660019e-01 | 0.177 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 6.662499e-01 | 0.176 |
| R-HSA-204005 | COPII-mediated vesicle transport | 6.662499e-01 | 0.176 |
| R-HSA-9638482 | Metal ion assimilation from the host | 6.709239e-01 | 0.173 |
| R-HSA-5632684 | Hedgehog 'on' state | 6.709239e-01 | 0.173 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 6.710680e-01 | 0.173 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 6.723923e-01 | 0.172 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 6.770693e-01 | 0.169 |
| R-HSA-5663084 | Diseases of carbohydrate metabolism | 6.800772e-01 | 0.167 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 6.838501e-01 | 0.165 |
| R-HSA-72312 | rRNA processing | 6.880992e-01 | 0.162 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 6.889770e-01 | 0.162 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 6.889770e-01 | 0.162 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 6.900880e-01 | 0.161 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 6.962246e-01 | 0.157 |
| R-HSA-15869 | Metabolism of nucleotides | 6.982551e-01 | 0.156 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 7.001073e-01 | 0.155 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 7.018667e-01 | 0.154 |
| R-HSA-416482 | G alpha (12/13) signalling events | 7.018667e-01 | 0.154 |
| R-HSA-5619084 | ABC transporter disorders | 7.018667e-01 | 0.154 |
| R-HSA-9955298 | SLC-mediated transport of organic anions | 7.018667e-01 | 0.154 |
| R-HSA-191273 | Cholesterol biosynthesis | 7.018667e-01 | 0.154 |
| R-HSA-9610379 | HCMV Late Events | 7.052416e-01 | 0.152 |
| R-HSA-9659379 | Sensory processing of sound | 7.060440e-01 | 0.151 |
| R-HSA-5579029 | Metabolic disorders of biological oxidation enzymes | 7.060440e-01 | 0.151 |
| R-HSA-9711097 | Cellular response to starvation | 7.081976e-01 | 0.150 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 7.081976e-01 | 0.150 |
| R-HSA-5633007 | Regulation of TP53 Activity | 7.140356e-01 | 0.146 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 7.221783e-01 | 0.141 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 7.221783e-01 | 0.141 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 7.260721e-01 | 0.139 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 7.260721e-01 | 0.139 |
| R-HSA-1500620 | Meiosis | 7.299117e-01 | 0.137 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 7.336976e-01 | 0.134 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 7.336976e-01 | 0.134 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 7.374307e-01 | 0.132 |
| R-HSA-9645723 | Diseases of programmed cell death | 7.447414e-01 | 0.128 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 7.453016e-01 | 0.128 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 7.468216e-01 | 0.127 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 7.470425e-01 | 0.127 |
| R-HSA-112310 | Neurotransmitter release cycle | 7.518493e-01 | 0.124 |
| R-HSA-5689880 | Ub-specific processing proteases | 7.522159e-01 | 0.124 |
| R-HSA-74752 | Signaling by Insulin receptor | 7.621435e-01 | 0.118 |
| R-HSA-611105 | Respiratory electron transport | 7.647535e-01 | 0.116 |
| R-HSA-2559583 | Cellular Senescence | 7.696131e-01 | 0.114 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 7.767392e-01 | 0.110 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 7.783641e-01 | 0.109 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 7.783641e-01 | 0.109 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 7.814735e-01 | 0.107 |
| R-HSA-375276 | Peptide ligand-binding receptors | 7.836726e-01 | 0.106 |
| R-HSA-382556 | ABC-family proteins mediated transport | 7.905437e-01 | 0.102 |
| R-HSA-9020702 | Interleukin-1 signaling | 7.934831e-01 | 0.100 |
| R-HSA-9833110 | RSV-host interactions | 8.048354e-01 | 0.094 |
| R-HSA-163125 | Post-translational modification: synthesis of GPI-anchored proteins | 8.048354e-01 | 0.094 |
| R-HSA-5696398 | Nucleotide Excision Repair | 8.075750e-01 | 0.093 |
| R-HSA-389948 | Co-inhibition by PD-1 | 8.135901e-01 | 0.090 |
| R-HSA-9640148 | Infection with Enterobacteria | 8.195019e-01 | 0.086 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 8.203722e-01 | 0.086 |
| R-HSA-9007101 | Rab regulation of trafficking | 8.421419e-01 | 0.075 |
| R-HSA-2980736 | Peptide hormone metabolism | 8.421419e-01 | 0.075 |
| R-HSA-73886 | Chromosome Maintenance | 8.508294e-01 | 0.070 |
| R-HSA-9717207 | Sensory perception of sweet, bitter, and umami (glutamate) taste | 8.549930e-01 | 0.068 |
| R-HSA-6809371 | Formation of the cornified envelope | 8.570312e-01 | 0.067 |
| R-HSA-1474165 | Reproduction | 8.723425e-01 | 0.059 |
| R-HSA-9717189 | Sensory perception of taste | 8.741379e-01 | 0.058 |
| R-HSA-9843745 | Adipogenesis | 8.741379e-01 | 0.058 |
| R-HSA-5668914 | Diseases of metabolism | 8.762160e-01 | 0.057 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 8.770311e-01 | 0.057 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 8.797467e-01 | 0.056 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 8.860206e-01 | 0.053 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 8.982389e-01 | 0.047 |
| R-HSA-5688426 | Deubiquitination | 8.995624e-01 | 0.046 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.033924e-01 | 0.044 |
| R-HSA-9679191 | Potential therapeutics for SARS | 9.065386e-01 | 0.043 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.072240e-01 | 0.042 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 9.078548e-01 | 0.042 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 9.091526e-01 | 0.041 |
| R-HSA-446652 | Interleukin-1 family signaling | 9.091526e-01 | 0.041 |
| R-HSA-9006936 | Signaling by TGFB family members | 9.189004e-01 | 0.037 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 9.262695e-01 | 0.033 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.293592e-01 | 0.032 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 9.325685e-01 | 0.030 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 9.335195e-01 | 0.030 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 9.335195e-01 | 0.030 |
| R-HSA-3781865 | Diseases of glycosylation | 9.431389e-01 | 0.025 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 9.499686e-01 | 0.022 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 9.520586e-01 | 0.021 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 9.566032e-01 | 0.019 |
| R-HSA-6805567 | Keratinization | 9.590048e-01 | 0.018 |
| R-HSA-418990 | Adherens junctions interactions | 9.654441e-01 | 0.015 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.708758e-01 | 0.013 |
| R-HSA-500792 | GPCR ligand binding | 9.732296e-01 | 0.012 |
| R-HSA-4839726 | Chromatin organization | 9.777899e-01 | 0.010 |
| R-HSA-421270 | Cell-cell junction organization | 9.784150e-01 | 0.009 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.808972e-01 | 0.008 |
| R-HSA-416476 | G alpha (q) signalling events | 9.820723e-01 | 0.008 |
| R-HSA-8978868 | Fatty acid metabolism | 9.837242e-01 | 0.007 |
| R-HSA-1483257 | Phospholipid metabolism | 9.884922e-01 | 0.005 |
| R-HSA-8957322 | Metabolism of steroids | 9.924048e-01 | 0.003 |
| R-HSA-73894 | DNA Repair | 9.954703e-01 | 0.002 |
| R-HSA-211859 | Biological oxidations | 9.962295e-01 | 0.002 |
| R-HSA-1430728 | Metabolism | 9.986749e-01 | 0.001 |
| R-HSA-9709957 | Sensory Perception | 9.997161e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.999381e-01 | 0.000 |
| R-HSA-381753 | Olfactory Signaling Pathway | 9.999973e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.875 | 0.244 | 2 | 0.828 |
RIPK3 |
0.855 | 0.098 | 3 | 0.789 |
CDC7 |
0.855 | 0.018 | 1 | 0.823 |
CLK3 |
0.855 | 0.153 | 1 | 0.811 |
ULK2 |
0.854 | 0.004 | 2 | 0.762 |
MOS |
0.854 | 0.098 | 1 | 0.848 |
NLK |
0.852 | 0.049 | 1 | 0.778 |
DSTYK |
0.852 | 0.064 | 2 | 0.800 |
CHAK2 |
0.852 | 0.104 | -1 | 0.792 |
PRPK |
0.851 | -0.123 | -1 | 0.730 |
RAF1 |
0.851 | -0.005 | 1 | 0.793 |
IKKB |
0.850 | -0.040 | -2 | 0.810 |
PIM3 |
0.850 | 0.018 | -3 | 0.787 |
FAM20C |
0.850 | 0.201 | 2 | 0.647 |
SKMLCK |
0.850 | 0.103 | -2 | 0.926 |
GCN2 |
0.850 | -0.097 | 2 | 0.735 |
NEK7 |
0.849 | 0.009 | -3 | 0.832 |
TBK1 |
0.848 | -0.046 | 1 | 0.681 |
NEK6 |
0.847 | 0.039 | -2 | 0.904 |
BMPR2 |
0.847 | -0.052 | -2 | 0.916 |
ERK5 |
0.846 | 0.027 | 1 | 0.743 |
CAMK1B |
0.846 | -0.024 | -3 | 0.804 |
WNK1 |
0.846 | 0.001 | -2 | 0.945 |
MLK1 |
0.846 | 0.019 | 2 | 0.749 |
PDHK4 |
0.845 | -0.205 | 1 | 0.800 |
ULK1 |
0.845 | -0.033 | -3 | 0.814 |
PKN3 |
0.845 | 0.008 | -3 | 0.791 |
IKKA |
0.845 | 0.067 | -2 | 0.786 |
ATR |
0.845 | -0.036 | 1 | 0.789 |
IRE1 |
0.844 | 0.053 | 1 | 0.808 |
CAMK2G |
0.844 | -0.057 | 2 | 0.762 |
ANKRD3 |
0.844 | 0.143 | 1 | 0.827 |
MST4 |
0.844 | 0.025 | 2 | 0.765 |
IKKE |
0.843 | -0.064 | 1 | 0.672 |
PDHK1 |
0.843 | -0.111 | 1 | 0.792 |
PKN2 |
0.843 | 0.031 | -3 | 0.793 |
PKCD |
0.843 | 0.073 | 2 | 0.733 |
WNK3 |
0.842 | -0.082 | 1 | 0.775 |
NDR2 |
0.842 | -0.047 | -3 | 0.797 |
CDKL1 |
0.842 | -0.025 | -3 | 0.741 |
MTOR |
0.842 | -0.174 | 1 | 0.722 |
GRK1 |
0.842 | 0.084 | -2 | 0.807 |
TGFBR2 |
0.841 | -0.033 | -2 | 0.803 |
CAMLCK |
0.841 | 0.012 | -2 | 0.918 |
DAPK2 |
0.841 | 0.034 | -3 | 0.815 |
KIS |
0.840 | 0.033 | 1 | 0.649 |
TSSK2 |
0.840 | 0.044 | -5 | 0.795 |
NIK |
0.840 | -0.055 | -3 | 0.843 |
MARK4 |
0.840 | -0.024 | 4 | 0.882 |
RIPK1 |
0.840 | -0.046 | 1 | 0.813 |
NEK9 |
0.840 | -0.035 | 2 | 0.776 |
TSSK1 |
0.840 | 0.053 | -3 | 0.826 |
NUAK2 |
0.839 | -0.030 | -3 | 0.790 |
PRKD1 |
0.839 | -0.025 | -3 | 0.769 |
IRE2 |
0.839 | 0.082 | 2 | 0.742 |
GRK5 |
0.839 | -0.087 | -3 | 0.846 |
AMPKA1 |
0.838 | -0.019 | -3 | 0.807 |
MLK3 |
0.838 | 0.071 | 2 | 0.674 |
HUNK |
0.837 | -0.109 | 2 | 0.758 |
PKR |
0.837 | 0.119 | 1 | 0.843 |
PRKD2 |
0.837 | 0.005 | -3 | 0.711 |
CDKL5 |
0.837 | -0.017 | -3 | 0.725 |
BCKDK |
0.837 | -0.111 | -1 | 0.744 |
SRPK1 |
0.836 | 0.021 | -3 | 0.679 |
HIPK4 |
0.835 | -0.012 | 1 | 0.773 |
PIM1 |
0.835 | 0.009 | -3 | 0.719 |
NDR1 |
0.835 | -0.071 | -3 | 0.777 |
GRK6 |
0.834 | -0.007 | 1 | 0.822 |
PKACG |
0.834 | 0.008 | -2 | 0.838 |
ATM |
0.834 | 0.019 | 1 | 0.732 |
MLK4 |
0.834 | 0.071 | 2 | 0.674 |
CHAK1 |
0.833 | 0.003 | 2 | 0.719 |
BMPR1B |
0.833 | 0.133 | 1 | 0.796 |
PLK1 |
0.833 | 0.050 | -2 | 0.838 |
RSK2 |
0.832 | -0.022 | -3 | 0.692 |
CDK8 |
0.832 | -0.012 | 1 | 0.612 |
MNK2 |
0.832 | 0.023 | -2 | 0.872 |
MLK2 |
0.832 | -0.078 | 2 | 0.752 |
PKCZ |
0.831 | 0.031 | 2 | 0.728 |
ICK |
0.831 | -0.036 | -3 | 0.777 |
AURC |
0.831 | 0.053 | -2 | 0.739 |
RSK3 |
0.831 | -0.041 | -3 | 0.701 |
NIM1 |
0.831 | -0.093 | 3 | 0.787 |
P70S6KB |
0.831 | -0.026 | -3 | 0.729 |
CDK5 |
0.831 | 0.055 | 1 | 0.641 |
PAK3 |
0.830 | -0.028 | -2 | 0.858 |
DLK |
0.830 | -0.110 | 1 | 0.800 |
NUAK1 |
0.830 | -0.031 | -3 | 0.729 |
MELK |
0.830 | -0.019 | -3 | 0.745 |
GRK4 |
0.830 | -0.057 | -2 | 0.843 |
MASTL |
0.830 | -0.241 | -2 | 0.870 |
P90RSK |
0.830 | -0.059 | -3 | 0.700 |
LATS1 |
0.830 | 0.091 | -3 | 0.787 |
PAK1 |
0.829 | -0.004 | -2 | 0.854 |
AMPKA2 |
0.829 | -0.046 | -3 | 0.769 |
PKCB |
0.829 | 0.014 | 2 | 0.670 |
TTBK2 |
0.829 | -0.135 | 2 | 0.690 |
NEK2 |
0.829 | -0.044 | 2 | 0.750 |
VRK2 |
0.829 | 0.001 | 1 | 0.847 |
PKCA |
0.828 | 0.017 | 2 | 0.670 |
CAMK4 |
0.828 | -0.073 | -3 | 0.773 |
PKCG |
0.828 | -0.008 | 2 | 0.677 |
LATS2 |
0.828 | -0.076 | -5 | 0.729 |
IRAK4 |
0.828 | 0.055 | 1 | 0.805 |
CAMK2D |
0.828 | -0.112 | -3 | 0.797 |
SRPK2 |
0.827 | 0.004 | -3 | 0.597 |
ALK4 |
0.827 | -0.004 | -2 | 0.833 |
CDK1 |
0.827 | 0.050 | 1 | 0.585 |
MAPKAPK3 |
0.827 | -0.102 | -3 | 0.715 |
AURB |
0.826 | 0.041 | -2 | 0.736 |
CDK19 |
0.826 | -0.018 | 1 | 0.572 |
PKCH |
0.826 | -0.006 | 2 | 0.671 |
QSK |
0.826 | -0.035 | 4 | 0.864 |
TGFBR1 |
0.825 | 0.017 | -2 | 0.799 |
QIK |
0.825 | -0.107 | -3 | 0.793 |
ACVR2B |
0.825 | 0.061 | -2 | 0.809 |
PINK1 |
0.825 | -0.003 | 1 | 0.818 |
PKG2 |
0.825 | 0.041 | -2 | 0.774 |
MNK1 |
0.824 | 0.008 | -2 | 0.877 |
SMG1 |
0.824 | -0.051 | 1 | 0.734 |
PRKD3 |
0.823 | -0.043 | -3 | 0.675 |
MYLK4 |
0.823 | -0.010 | -2 | 0.851 |
PRP4 |
0.823 | 0.086 | -3 | 0.785 |
CDK2 |
0.823 | 0.029 | 1 | 0.667 |
PAK2 |
0.823 | -0.033 | -2 | 0.841 |
CDK13 |
0.823 | -0.021 | 1 | 0.591 |
ACVR2A |
0.823 | 0.028 | -2 | 0.793 |
DYRK2 |
0.823 | -0.015 | 1 | 0.671 |
MEK1 |
0.822 | -0.133 | 2 | 0.776 |
NEK5 |
0.822 | 0.035 | 1 | 0.802 |
BRAF |
0.821 | 0.064 | -4 | 0.841 |
YSK4 |
0.821 | -0.072 | 1 | 0.715 |
GRK7 |
0.821 | 0.044 | 1 | 0.737 |
CDK7 |
0.821 | -0.053 | 1 | 0.619 |
PLK4 |
0.821 | -0.051 | 2 | 0.650 |
MARK2 |
0.821 | -0.027 | 4 | 0.795 |
CAMK2B |
0.821 | -0.035 | 2 | 0.731 |
SIK |
0.820 | -0.066 | -3 | 0.705 |
MEKK1 |
0.820 | 0.009 | 1 | 0.786 |
PHKG1 |
0.820 | -0.096 | -3 | 0.775 |
TLK2 |
0.820 | -0.043 | 1 | 0.764 |
P38A |
0.820 | 0.007 | 1 | 0.645 |
PLK3 |
0.820 | -0.010 | 2 | 0.737 |
ALK2 |
0.820 | 0.024 | -2 | 0.814 |
SRPK3 |
0.820 | -0.023 | -3 | 0.663 |
CDK18 |
0.820 | 0.001 | 1 | 0.553 |
MARK3 |
0.819 | -0.035 | 4 | 0.823 |
CAMK1G |
0.819 | -0.033 | -3 | 0.699 |
MSK2 |
0.819 | -0.071 | -3 | 0.674 |
SGK3 |
0.819 | 0.006 | -3 | 0.700 |
MAPKAPK2 |
0.819 | -0.071 | -3 | 0.661 |
BMPR1A |
0.819 | 0.113 | 1 | 0.780 |
SNRK |
0.819 | -0.142 | 2 | 0.699 |
ERK2 |
0.819 | -0.004 | 1 | 0.609 |
HRI |
0.819 | -0.085 | -2 | 0.883 |
ZAK |
0.819 | 0.004 | 1 | 0.754 |
SSTK |
0.818 | 0.014 | 4 | 0.871 |
PAK6 |
0.818 | -0.011 | -2 | 0.786 |
WNK4 |
0.818 | -0.065 | -2 | 0.940 |
CDK17 |
0.818 | 0.001 | 1 | 0.503 |
IRAK1 |
0.818 | -0.083 | -1 | 0.666 |
MEKK2 |
0.817 | 0.016 | 2 | 0.750 |
RSK4 |
0.817 | -0.016 | -3 | 0.674 |
ERK1 |
0.817 | 0.001 | 1 | 0.560 |
CLK4 |
0.817 | -0.013 | -3 | 0.689 |
CHK1 |
0.817 | -0.058 | -3 | 0.784 |
SMMLCK |
0.817 | 0.017 | -3 | 0.760 |
JNK3 |
0.817 | -0.000 | 1 | 0.598 |
PERK |
0.816 | -0.106 | -2 | 0.857 |
CLK1 |
0.816 | 0.000 | -3 | 0.668 |
CDK3 |
0.816 | 0.063 | 1 | 0.521 |
PKACB |
0.816 | 0.015 | -2 | 0.769 |
AURA |
0.815 | 0.026 | -2 | 0.688 |
GRK2 |
0.815 | -0.019 | -2 | 0.734 |
PKCT |
0.815 | -0.017 | 2 | 0.682 |
DRAK1 |
0.815 | -0.061 | 1 | 0.748 |
P38B |
0.814 | 0.006 | 1 | 0.574 |
MEKK3 |
0.814 | -0.081 | 1 | 0.762 |
AKT2 |
0.814 | -0.011 | -3 | 0.613 |
JNK2 |
0.814 | 0.002 | 1 | 0.558 |
CDK12 |
0.814 | -0.027 | 1 | 0.564 |
PIM2 |
0.814 | -0.026 | -3 | 0.673 |
MSK1 |
0.814 | -0.030 | -3 | 0.682 |
DCAMKL1 |
0.814 | -0.050 | -3 | 0.727 |
CAMK2A |
0.813 | -0.077 | 2 | 0.711 |
MEK5 |
0.813 | -0.168 | 2 | 0.767 |
P38G |
0.813 | 0.003 | 1 | 0.490 |
HIPK1 |
0.813 | -0.014 | 1 | 0.687 |
MST3 |
0.813 | -0.011 | 2 | 0.741 |
PKCI |
0.812 | -0.009 | 2 | 0.694 |
MARK1 |
0.812 | -0.079 | 4 | 0.847 |
AKT1 |
0.812 | 0.023 | -3 | 0.635 |
PRKX |
0.812 | 0.040 | -3 | 0.612 |
CK1E |
0.811 | -0.031 | -3 | 0.548 |
TLK1 |
0.811 | -0.045 | -2 | 0.843 |
BRSK2 |
0.811 | -0.144 | -3 | 0.762 |
BRSK1 |
0.811 | -0.115 | -3 | 0.740 |
NEK8 |
0.811 | -0.026 | 2 | 0.770 |
CDK9 |
0.811 | -0.069 | 1 | 0.597 |
TAO3 |
0.811 | 0.001 | 1 | 0.746 |
DCAMKL2 |
0.810 | -0.045 | -3 | 0.745 |
MPSK1 |
0.810 | -0.007 | 1 | 0.780 |
DYRK1A |
0.810 | -0.031 | 1 | 0.690 |
PHKG2 |
0.810 | -0.065 | -3 | 0.741 |
CDK14 |
0.810 | -0.008 | 1 | 0.597 |
HIPK2 |
0.809 | -0.011 | 1 | 0.581 |
CAMKK1 |
0.809 | -0.062 | -2 | 0.838 |
P38D |
0.809 | 0.030 | 1 | 0.506 |
TTBK1 |
0.809 | -0.114 | 2 | 0.631 |
GAK |
0.807 | 0.029 | 1 | 0.810 |
MAPKAPK5 |
0.807 | -0.173 | -3 | 0.656 |
DAPK3 |
0.807 | 0.036 | -3 | 0.740 |
DNAPK |
0.806 | -0.104 | 1 | 0.626 |
HIPK3 |
0.806 | -0.050 | 1 | 0.669 |
CAMKK2 |
0.806 | -0.053 | -2 | 0.834 |
PKCE |
0.806 | 0.010 | 2 | 0.659 |
MST2 |
0.805 | 0.058 | 1 | 0.756 |
CDK16 |
0.805 | 0.004 | 1 | 0.519 |
CLK2 |
0.805 | 0.016 | -3 | 0.680 |
TAO2 |
0.804 | -0.056 | 2 | 0.784 |
CK1D |
0.804 | -0.020 | -3 | 0.499 |
P70S6K |
0.804 | -0.071 | -3 | 0.632 |
DYRK3 |
0.804 | -0.018 | 1 | 0.700 |
LKB1 |
0.803 | -0.082 | -3 | 0.844 |
CAMK1D |
0.803 | -0.044 | -3 | 0.618 |
EEF2K |
0.803 | 0.030 | 3 | 0.855 |
DYRK1B |
0.803 | -0.032 | 1 | 0.618 |
NEK4 |
0.803 | -0.084 | 1 | 0.755 |
PASK |
0.803 | -0.058 | -3 | 0.817 |
VRK1 |
0.802 | 0.009 | 2 | 0.807 |
MINK |
0.802 | 0.007 | 1 | 0.742 |
ERK7 |
0.802 | -0.003 | 2 | 0.504 |
HGK |
0.802 | 0.003 | 3 | 0.883 |
CK1A2 |
0.802 | -0.023 | -3 | 0.497 |
PLK2 |
0.802 | 0.088 | -3 | 0.836 |
NEK11 |
0.802 | -0.154 | 1 | 0.754 |
STK33 |
0.802 | -0.070 | 2 | 0.617 |
PKACA |
0.801 | -0.003 | -2 | 0.718 |
TNIK |
0.801 | 0.032 | 3 | 0.877 |
CDK10 |
0.801 | -0.017 | 1 | 0.588 |
PDK1 |
0.801 | -0.093 | 1 | 0.769 |
CDK6 |
0.800 | 0.011 | 1 | 0.572 |
LRRK2 |
0.799 | -0.080 | 2 | 0.793 |
GRK3 |
0.799 | -0.030 | -2 | 0.682 |
GCK |
0.799 | -0.031 | 1 | 0.743 |
NEK1 |
0.799 | -0.048 | 1 | 0.779 |
BUB1 |
0.799 | 0.072 | -5 | 0.729 |
CK2A2 |
0.798 | 0.041 | 1 | 0.694 |
CK1G1 |
0.798 | -0.077 | -3 | 0.525 |
PAK5 |
0.798 | -0.054 | -2 | 0.720 |
DAPK1 |
0.798 | 0.006 | -3 | 0.725 |
PKN1 |
0.798 | -0.049 | -3 | 0.650 |
DYRK4 |
0.797 | -0.045 | 1 | 0.586 |
GSK3B |
0.796 | -0.057 | 4 | 0.422 |
LOK |
0.796 | -0.054 | -2 | 0.850 |
MAP3K15 |
0.796 | -0.102 | 1 | 0.721 |
TAK1 |
0.796 | -0.060 | 1 | 0.776 |
GSK3A |
0.796 | -0.016 | 4 | 0.431 |
RIPK2 |
0.795 | -0.135 | 1 | 0.711 |
ROCK2 |
0.795 | 0.023 | -3 | 0.723 |
AKT3 |
0.794 | -0.004 | -3 | 0.546 |
CDK4 |
0.794 | -0.015 | 1 | 0.552 |
PAK4 |
0.794 | -0.049 | -2 | 0.714 |
MST1 |
0.794 | -0.028 | 1 | 0.741 |
TTK |
0.794 | 0.110 | -2 | 0.839 |
CAMK1A |
0.793 | -0.037 | -3 | 0.583 |
MRCKB |
0.793 | -0.013 | -3 | 0.674 |
MEKK6 |
0.793 | -0.159 | 1 | 0.738 |
SLK |
0.793 | -0.051 | -2 | 0.781 |
HASPIN |
0.793 | 0.048 | -1 | 0.613 |
CHK2 |
0.792 | -0.056 | -3 | 0.554 |
MRCKA |
0.792 | -0.007 | -3 | 0.681 |
JNK1 |
0.792 | -0.025 | 1 | 0.549 |
YSK1 |
0.791 | -0.053 | 2 | 0.738 |
KHS2 |
0.790 | 0.003 | 1 | 0.732 |
HPK1 |
0.790 | -0.093 | 1 | 0.727 |
KHS1 |
0.790 | -0.032 | 1 | 0.723 |
SGK1 |
0.789 | -0.019 | -3 | 0.527 |
MAK |
0.788 | 0.004 | -2 | 0.767 |
NEK3 |
0.788 | -0.103 | 1 | 0.719 |
PBK |
0.787 | -0.040 | 1 | 0.724 |
MEK2 |
0.787 | -0.188 | 2 | 0.760 |
OSR1 |
0.787 | 0.055 | 2 | 0.739 |
CK2A1 |
0.787 | 0.016 | 1 | 0.670 |
MYO3B |
0.785 | 0.033 | 2 | 0.755 |
DMPK1 |
0.785 | 0.019 | -3 | 0.689 |
PKG1 |
0.784 | -0.020 | -2 | 0.694 |
MYO3A |
0.783 | 0.033 | 1 | 0.770 |
MOK |
0.783 | -0.041 | 1 | 0.711 |
PDHK3_TYR |
0.782 | 0.068 | 4 | 0.912 |
EPHA6 |
0.782 | 0.208 | -1 | 0.798 |
ROCK1 |
0.782 | -0.000 | -3 | 0.686 |
BIKE |
0.778 | 0.005 | 1 | 0.695 |
EPHB4 |
0.777 | 0.187 | -1 | 0.788 |
BMPR2_TYR |
0.777 | 0.084 | -1 | 0.773 |
ALPHAK3 |
0.777 | 0.003 | -1 | 0.682 |
TESK1_TYR |
0.776 | -0.070 | 3 | 0.868 |
PKMYT1_TYR |
0.775 | -0.086 | 3 | 0.859 |
YANK3 |
0.775 | -0.047 | 2 | 0.425 |
TYRO3 |
0.773 | 0.058 | 3 | 0.849 |
SBK |
0.773 | -0.084 | -3 | 0.485 |
TAO1 |
0.773 | -0.083 | 1 | 0.678 |
ROS1 |
0.773 | 0.076 | 3 | 0.827 |
MST1R |
0.772 | 0.051 | 3 | 0.863 |
CSF1R |
0.772 | 0.094 | 3 | 0.851 |
ASK1 |
0.772 | -0.136 | 1 | 0.713 |
PDHK4_TYR |
0.771 | -0.054 | 2 | 0.807 |
RET |
0.771 | 0.020 | 1 | 0.760 |
TYK2 |
0.771 | 0.006 | 1 | 0.759 |
MAP2K7_TYR |
0.771 | -0.229 | 2 | 0.801 |
LIMK2_TYR |
0.771 | -0.041 | -3 | 0.856 |
MAP2K4_TYR |
0.771 | -0.130 | -1 | 0.756 |
PINK1_TYR |
0.770 | -0.146 | 1 | 0.806 |
MAP2K6_TYR |
0.770 | -0.074 | -1 | 0.767 |
CRIK |
0.770 | -0.051 | -3 | 0.628 |
EPHB1 |
0.769 | 0.160 | 1 | 0.810 |
PDHK1_TYR |
0.769 | -0.066 | -1 | 0.780 |
JAK2 |
0.769 | 0.026 | 1 | 0.751 |
PDGFRB |
0.769 | 0.085 | 3 | 0.866 |
DDR1 |
0.768 | -0.004 | 4 | 0.859 |
EPHB2 |
0.768 | 0.165 | -1 | 0.777 |
LIMK1_TYR |
0.768 | -0.122 | 2 | 0.807 |
YES1 |
0.767 | 0.045 | -1 | 0.719 |
EPHB3 |
0.767 | 0.124 | -1 | 0.770 |
ABL2 |
0.767 | 0.043 | -1 | 0.693 |
HCK |
0.767 | 0.060 | -1 | 0.709 |
FER |
0.767 | 0.028 | 1 | 0.823 |
TNK2 |
0.767 | 0.051 | 3 | 0.844 |
LCK |
0.767 | 0.101 | -1 | 0.712 |
JAK3 |
0.767 | 0.086 | 1 | 0.737 |
INSRR |
0.766 | 0.104 | 3 | 0.801 |
FLT3 |
0.766 | 0.060 | 3 | 0.849 |
KDR |
0.765 | 0.092 | 3 | 0.812 |
EPHA4 |
0.765 | 0.078 | 2 | 0.730 |
BLK |
0.765 | 0.113 | -1 | 0.711 |
KIT |
0.764 | 0.044 | 3 | 0.858 |
TXK |
0.763 | 0.079 | 1 | 0.803 |
CK1A |
0.763 | -0.056 | -3 | 0.407 |
TNNI3K_TYR |
0.763 | 0.041 | 1 | 0.812 |
SRMS |
0.763 | 0.037 | 1 | 0.817 |
ABL1 |
0.763 | 0.009 | -1 | 0.683 |
STLK3 |
0.762 | -0.122 | 1 | 0.714 |
ALK |
0.762 | 0.080 | 3 | 0.804 |
FGFR2 |
0.762 | 0.046 | 3 | 0.829 |
FGR |
0.762 | -0.034 | 1 | 0.806 |
ITK |
0.762 | 0.025 | -1 | 0.693 |
EPHA7 |
0.761 | 0.110 | 2 | 0.748 |
FGFR1 |
0.761 | 0.061 | 3 | 0.822 |
WEE1_TYR |
0.761 | 0.006 | -1 | 0.650 |
AXL |
0.761 | 0.007 | 3 | 0.829 |
PDGFRA |
0.760 | -0.005 | 3 | 0.870 |
TNK1 |
0.760 | -0.032 | 3 | 0.817 |
MET |
0.760 | 0.041 | 3 | 0.843 |
TEK |
0.759 | -0.024 | 3 | 0.804 |
AAK1 |
0.759 | 0.026 | 1 | 0.591 |
LTK |
0.759 | 0.039 | 3 | 0.808 |
MERTK |
0.758 | 0.027 | 3 | 0.806 |
TEC |
0.758 | 0.013 | -1 | 0.636 |
DDR2 |
0.757 | 0.117 | 3 | 0.815 |
INSR |
0.756 | 0.061 | 3 | 0.783 |
FRK |
0.756 | 0.048 | -1 | 0.720 |
JAK1 |
0.756 | -0.009 | 1 | 0.691 |
EPHA3 |
0.756 | 0.044 | 2 | 0.719 |
BMX |
0.756 | -0.004 | -1 | 0.621 |
BTK |
0.756 | -0.058 | -1 | 0.659 |
EPHA1 |
0.755 | 0.022 | 3 | 0.835 |
NTRK2 |
0.755 | 0.031 | 3 | 0.814 |
NTRK1 |
0.754 | 0.006 | -1 | 0.745 |
LYN |
0.754 | 0.036 | 3 | 0.785 |
FYN |
0.754 | 0.051 | -1 | 0.682 |
EPHA5 |
0.754 | 0.123 | 2 | 0.725 |
PTK2 |
0.754 | 0.154 | -1 | 0.769 |
FGFR3 |
0.752 | 0.025 | 3 | 0.808 |
FLT1 |
0.752 | 0.043 | -1 | 0.780 |
FLT4 |
0.752 | 0.006 | 3 | 0.789 |
PTK2B |
0.752 | 0.035 | -1 | 0.671 |
EPHA8 |
0.750 | 0.060 | -1 | 0.727 |
ERBB2 |
0.750 | -0.056 | 1 | 0.716 |
NTRK3 |
0.749 | 0.003 | -1 | 0.692 |
PTK6 |
0.749 | -0.122 | -1 | 0.617 |
MATK |
0.749 | -0.032 | -1 | 0.630 |
CK1G3 |
0.746 | -0.054 | -3 | 0.366 |
SRC |
0.745 | -0.012 | -1 | 0.673 |
EGFR |
0.745 | 0.016 | 1 | 0.639 |
FGFR4 |
0.743 | 0.025 | -1 | 0.696 |
SYK |
0.743 | 0.089 | -1 | 0.712 |
EPHA2 |
0.743 | 0.090 | -1 | 0.732 |
NEK10_TYR |
0.742 | -0.205 | 1 | 0.600 |
YANK2 |
0.741 | -0.072 | 2 | 0.440 |
IGF1R |
0.741 | 0.026 | 3 | 0.723 |
CSK |
0.739 | -0.069 | 2 | 0.752 |
MUSK |
0.736 | -0.088 | 1 | 0.621 |
ERBB4 |
0.734 | 0.010 | 1 | 0.670 |
FES |
0.729 | -0.031 | -1 | 0.601 |
CK1G2 |
0.721 | -0.077 | -3 | 0.457 |
ZAP70 |
0.715 | -0.033 | -1 | 0.624 |