Motif 827 (n=206)
Position-wise Probabilities
Download
| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A1B0GU03 | None | S350 | ochoa | Cathepsin D (EC 3.4.23.5) | None |
| A6NGC4 | TLCD2 | S235 | ochoa | TLC domain-containing protein 2 | Regulates the composition and fluidity of the plasma membrane (PubMed:30509349). Inhibits the incorporation of membrane-fluidizing phospholipids containing omega-3 long-chain polyunsaturated fatty acids (LCPUFA) and thereby promotes membrane rigidity (PubMed:30509349). Does not appear to have any effect on LCPUFA synthesis (PubMed:30509349). {ECO:0000269|PubMed:30509349}. |
| O00482 | NR5A2 | S238 | psp | Nuclear receptor subfamily 5 group A member 2 (Alpha-1-fetoprotein transcription factor) (B1-binding factor) (hB1F) (CYP7A promoter-binding factor) (Hepatocytic transcription factor) (Liver receptor homolog 1) (LRH-1) | Orphan nuclear receptor that binds DNA as a monomer to the 5'-TCAAGGCCA-3' sequence and controls expression of target genes: regulates key biological processes, such as early embryonic development, cholesterol and bile acid synthesis pathways, as well as liver and pancreas morphogenesis (PubMed:16289203, PubMed:18410128, PubMed:21614002, PubMed:32433991, PubMed:38409506, PubMed:9786908). Ligand-binding causes conformational change which causes recruitment of coactivators, promoting target gene activation (PubMed:21614002). The specific ligand is unknown, but specific phospholipids, such as phosphatidylethanolamine, phosphatidylserine, dilauroyl phosphatidylcholine and diundecanoyl phosphatidylcholine can act as ligand in vitro (PubMed:15707893, PubMed:15723037, PubMed:15897460, PubMed:21614002, PubMed:22504882, PubMed:23737522, PubMed:26416531, PubMed:26553876). Acts as a pioneer transcription factor, which unwraps target DNA from histones and elicits local opening of closed chromatin (PubMed:38409506). Plays a central role during preimplantation stages of embryonic development (By similarity). Plays a minor role in zygotic genome activation (ZGA) by regulating a small set of two-cell stage genes (By similarity). Plays a major role in morula development (2-16 cells embryos) by acting as a master regulator at the 8-cell stage, controlling expression of lineage-specifying transcription factors and genes involved in mitosis, telomere maintenance and DNA repair (By similarity). Zygotic NR5A2 binds to both closed and open chromatin with other transcription factors, often at SINE B1/Alu repeats DNA elements, promoting chromatin accessibility at nearby regulatory regions (By similarity). Also involved in the epiblast stage of development and embryonic stem cell pluripotency, by promoting expression of POU5F1/OCT4 (PubMed:27984042). Regulates other processes later in development, such as formation of connective tissue in lower jaw and middle ear, neural stem cell differentiation, ovarian follicle development and Sertoli cell differentiation (By similarity). Involved in exocrine pancreas development and acinar cell differentiation (By similarity). Acts as an essential transcriptional regulator of lipid metabolism (PubMed:20159957). Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver (PubMed:10359768). Also acts as a negative regulator of inflammation in different organs, such as, liver and pancreas (PubMed:20159957). Protects against intestinal inflammation via its ability to regulate glucocorticoid production (By similarity). Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (PubMed:20159957). Acts as a regulator of immunity by promoting lymphocyte T-cell development, proliferation and effector functions (By similarity). Also involved in resolution of endoplasmic reticulum stress in the liver (By similarity). {ECO:0000250|UniProtKB:P45448, ECO:0000269|PubMed:10359768, ECO:0000269|PubMed:15707893, ECO:0000269|PubMed:15723037, ECO:0000269|PubMed:15897460, ECO:0000269|PubMed:16289203, ECO:0000269|PubMed:18410128, ECO:0000269|PubMed:20159957, ECO:0000269|PubMed:21614002, ECO:0000269|PubMed:22504882, ECO:0000269|PubMed:23737522, ECO:0000269|PubMed:26416531, ECO:0000269|PubMed:26553876, ECO:0000269|PubMed:27984042, ECO:0000269|PubMed:32433991, ECO:0000269|PubMed:38409506, ECO:0000269|PubMed:9786908}.; FUNCTION: [Isoform 3]: In constrast to isoform 1 and isoform 2, does not induce cholesterol 7-alpha-hydroxylase gene (CYP7A) promoter activity. {ECO:0000269|PubMed:10359768}.; FUNCTION: (Microbial infection) Plays a crucial role for hepatitis B virus gene transcription and DNA replication. Mechanistically, synergistically cooperates with HNF1A to up-regulate the activity of one of the critical cis-elements in the hepatitis B virus genome enhancer II (ENII). {ECO:0000269|PubMed:14728801, ECO:0000269|PubMed:9786908}. |
| O00571 | DDX3X | S492 | ochoa | ATP-dependent RNA helicase DDX3X (EC 3.6.4.13) (CAP-Rf) (DEAD box protein 3, X-chromosomal) (DEAD box, X isoform) (DBX) (Helicase-like protein 2) (HLP2) | Multifunctional ATP-dependent RNA helicase (PubMed:17357160, PubMed:21589879, PubMed:31575075). The ATPase activity can be stimulated by various ribo-and deoxynucleic acids indicative for a relaxed substrate specificity (PubMed:29222110). In vitro can unwind partially double-stranded DNA with a preference for 5'-single-stranded DNA overhangs (PubMed:17357160, PubMed:21589879). Binds RNA G-quadruplex (rG4s) structures, including those located in the 5'-UTR of NRAS mRNA (PubMed:30256975). Involved in many cellular processes, which do not necessarily require its ATPase/helicase catalytic activities (Probable). Involved in transcription regulation (PubMed:16818630, PubMed:18264132). Positively regulates CDKN1A/WAF1/CIP1 transcription in an SP1-dependent manner, hence inhibits cell growth. This function requires its ATPase, but not helicase activity (PubMed:16818630, PubMed:18264132). CDKN1A up-regulation may be cell-type specific (PubMed:18264132). Binds CDH1/E-cadherin promoter and represses its transcription (PubMed:18264132). Potentiates HNF4A-mediated MTTP transcriptional activation; this function requires ATPase, but not helicase activity. Facilitates HNF4A acetylation, possibly catalyzed by CREBBP/EP300, thereby increasing the DNA-binding affinity of HNF4 to its response element. In addition, disrupts the interaction between HNF4 and SHP that forms inactive heterodimers and enhances the formation of active HNF4 homodimers. By promoting HNF4A-induced MTTP expression, may play a role in lipid homeostasis (PubMed:28128295). May positively regulate TP53 transcription (PubMed:28842590). Associates with mRNPs, predominantly with spliced mRNAs carrying an exon junction complex (EJC) (PubMed:17095540, PubMed:18596238). Involved in the regulation of translation initiation (PubMed:17667941, PubMed:18628297, PubMed:22872150). Not involved in the general process of translation, but promotes efficient translation of selected complex mRNAs, containing highly structured 5'-untranslated regions (UTR) (PubMed:20837705, PubMed:22872150). This function depends on helicase activity (PubMed:20837705, PubMed:22872150). Might facilitate translation by resolving secondary structures of 5'-UTRs during ribosome scanning (PubMed:20837705). Alternatively, may act prior to 43S ribosomal scanning and promote 43S pre-initiation complex entry to mRNAs exhibiting specific RNA motifs, by performing local remodeling of transcript structures located close to the cap moiety (PubMed:22872150). Independently of its ATPase activity, promotes the assembly of functional 80S ribosomes and disassembles from ribosomes prior to the translation elongation process (PubMed:22323517). Positively regulates the translation of cyclin E1/CCNE1 mRNA and consequently promotes G1/S-phase transition during the cell cycle (PubMed:20837705). May activate TP53 translation (PubMed:28842590). Required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). Independently of its ATPase/helicase activity, enhances IRES-mediated translation; this activity requires interaction with EIF4E (PubMed:17667941, PubMed:22323517). Independently of its ATPase/helicase activity, has also been shown specifically repress cap-dependent translation, possibly by acting on translation initiation factor EIF4E (PubMed:17667941). Involved in innate immunity, acting as a viral RNA sensor. Binds viral RNAs and promotes the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:20127681, PubMed:21170385, PubMed:31575075). Potentiate MAVS/RIGI-mediated induction of IFNB in early stages of infection (PubMed:20127681, PubMed:21170385, PubMed:33674311). Enhances IFNB1 expression via IRF3/IRF7 pathway and participates in NFKB activation in the presence of MAVS and TBK1 (PubMed:18583960, PubMed:18636090, PubMed:19913487, PubMed:21170385, PubMed:27980081). Involved in TBK1 and IKBKE-dependent IRF3 activation leading to IFNB induction, acts as a scaffolding adapter that links IKBKE and IRF3 and coordinates their activation (PubMed:23478265). Involved in the TLR7/TLR8 signaling pathway leading to type I interferon induction, including IFNA4 production. In this context, acts as an upstream regulator of IRF7 activation by MAP3K14/NIK and CHUK/IKKA. Stimulates CHUK autophosphorylation and activation following physiological activation of the TLR7 and TLR8 pathways, leading to MAP3K14/CHUK-mediated activatory phosphorylation of IRF7 (PubMed:30341167). Also stimulates MAP3K14/CHUK-dependent NF-kappa-B signaling (PubMed:30341167). Negatively regulates TNF-induced IL6 and IL8 expression, via the NF-kappa-B pathway. May act by interacting with RELA/p65 and trapping it in the cytoplasm (PubMed:27736973). May also bind IFNB promoter; the function is independent of IRF3 (PubMed:18583960). Involved in both stress and inflammatory responses (By similarity). Independently of its ATPase/helicase activity, required for efficient stress granule assembly through its interaction with EIF4E, hence promotes survival in stressed cells (PubMed:21883093). Independently of its helicase activity, regulates NLRP3 inflammasome assembly through interaction with NLRP3 and hence promotes cell death by pyroptosis during inflammation. This function is independent of helicase activity (By similarity). Therefore DDX3X availability may be used to interpret stress signals and choose between pro-survival stress granules and pyroptotic NLRP3 inflammasomes and serve as a live-or-die checkpoint in stressed cells (By similarity). In association with GSK3A/B, negatively regulates extrinsic apoptotic signaling pathway via death domain receptors, including TNFRSF10B, slowing down the rate of CASP3 activation following death receptor stimulation (PubMed:18846110). Cleavage by caspases may inactivate DDX3X and relieve the inhibition (PubMed:18846110). Independently of its ATPase/helicase activity, allosteric activator of CSNK1E. Stimulates CSNK1E-mediated phosphorylation of DVL2, thereby involved in the positive regulation of Wnt/beta-catenin signaling pathway. Also activates CSNK1A1 and CSNK1D in vitro, but it is uncertain if these targets are physiologically relevant (PubMed:23413191, PubMed:29222110). ATPase and casein kinase-activating functions are mutually exclusive (PubMed:29222110). May be involved in mitotic chromosome segregation (PubMed:21730191). {ECO:0000250|UniProtKB:Q62167, ECO:0000269|PubMed:16818630, ECO:0000269|PubMed:17095540, ECO:0000269|PubMed:17357160, ECO:0000269|PubMed:17667941, ECO:0000269|PubMed:18264132, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:18596238, ECO:0000269|PubMed:18628297, ECO:0000269|PubMed:18636090, ECO:0000269|PubMed:18846110, ECO:0000269|PubMed:19913487, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20837705, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:21730191, ECO:0000269|PubMed:21883093, ECO:0000269|PubMed:22323517, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:23413191, ECO:0000269|PubMed:23478265, ECO:0000269|PubMed:27736973, ECO:0000269|PubMed:27980081, ECO:0000269|PubMed:28128295, ECO:0000269|PubMed:28842590, ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29222110, ECO:0000269|PubMed:30256975, ECO:0000269|PubMed:30341167, ECO:0000269|PubMed:31575075, ECO:0000269|PubMed:33674311, ECO:0000305}.; FUNCTION: (Microbial infection) Facilitates hepatitis C virus (HCV) replication (PubMed:29899501). During infection, HCV core protein inhibits the interaction between MAVS and DDX3X and therefore impairs MAVS-dependent INFB induction and might recruit DDX3X to HCV replication complex (PubMed:21170385). {ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates HIV-1 replication (PubMed:15507209, PubMed:18583960, PubMed:21589879, PubMed:22872150, PubMed:29899501). Acts as a cofactor for XPO1-mediated nuclear export of HIV-1 Rev RNAs (PubMed:15507209, PubMed:18583960, PubMed:29899501). This function is strongly stimulated in the presence of TBK1 and requires DDX3X ATPase activity (PubMed:18583960). {ECO:0000269|PubMed:15507209, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Zika virus (ZIKV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Dengue virus (DENV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Venezuelan equine encephalitis virus (VEEV) replication. {ECO:0000269|PubMed:27105836}. |
| O00763 | ACACB | S246 | ochoa | Acetyl-CoA carboxylase 2 (EC 6.4.1.2) (ACC-beta) | Mitochondrial enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA and plays a central role in fatty acid metabolism (PubMed:16854592, PubMed:19236960, PubMed:19900410, PubMed:20457939, PubMed:20952656, PubMed:26976583). Catalyzes a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:19236960, PubMed:20457939, PubMed:20952656, PubMed:26976583). Through the production of malonyl-CoA that allosterically inhibits carnitine palmitoyltransferase 1 at the mitochondria, negatively regulates fatty acid oxidation (By similarity). Together with its cytosolic isozyme ACACA, which is involved in de novo fatty acid biosynthesis, promotes lipid storage (By similarity). {ECO:0000250|UniProtKB:E9Q4Z2, ECO:0000269|PubMed:16854592, ECO:0000269|PubMed:19236960, ECO:0000269|PubMed:19900410, ECO:0000269|PubMed:20457939, ECO:0000269|PubMed:20952656, ECO:0000269|PubMed:26976583}. |
| O14617 | AP3D1 | S1070 | ochoa | AP-3 complex subunit delta-1 (AP-3 complex subunit delta) (Adaptor-related protein complex 3 subunit delta-1) (Delta-adaptin) | Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Involved in process of CD8+ T-cell and NK cell degranulation (PubMed:26744459). In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity). {ECO:0000250|UniProtKB:O54774, ECO:0000269|PubMed:26744459}. |
| O15055 | PER2 | S662 | psp | Period circadian protein homolog 2 (hPER2) (Circadian clock protein PERIOD 2) | Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndrome and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. PER1 and PER2 proteins transport CRY1 and CRY2 into the nucleus with appropriate circadian timing, but also contribute directly to repression of clock-controlled target genes through interaction with several classes of RNA-binding proteins, helicases and others transcriptional repressors. PER appears to regulate circadian control of transcription by at least three different modes. First, interacts directly with the CLOCK-BMAL1 at the tail end of the nascent transcript peak to recruit complexes containing the SIN3-HDAC that remodel chromatin to repress transcription. Second, brings H3K9 methyltransferases such as SUV39H1 and SUV39H2 to the E-box elements of the circadian target genes, like PER2 itself or PER1. The recruitment of each repressive modifier to the DNA seems to be very precisely temporally orchestrated by the large PER complex, the deacetylases acting before than the methyltransferases. Additionally, large PER complexes are also recruited to the target genes 3' termination site through interactions with RNA-binding proteins and helicases that may play a role in transcription termination to regulate transcription independently of CLOCK-BMAL1 interactions. Recruitment of large PER complexes to the elongating polymerase at PER and CRY termination sites inhibited SETX action, impeding RNA polymerase II release and thereby repressing transcriptional reinitiation. May propagate clock information to metabolic pathways via the interaction with nuclear receptors. Coactivator of PPARA and corepressor of NR1D1, binds rhythmically at the promoter of nuclear receptors target genes like BMAL1 or G6PC1. Directly and specifically represses PPARG proadipogenic activity by blocking PPARG recruitment to target promoters and thereby inhibiting transcriptional activation. Required for fatty acid and lipid metabolism, is involved as well in the regulation of circulating insulin levels. Plays an important role in the maintenance of cardiovascular functions through the regulation of NO and vasodilatatory prostaglandins production in aortas. Controls circadian glutamate uptake in synaptic vesicles through the regulation of VGLUT1 expression. May also be involved in the regulation of inflammatory processes. Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1 and ATF4. Negatively regulates the formation of the TIMELESS-CRY1 complex by competing with TIMELESS for binding to CRY1. {ECO:0000250|UniProtKB:O54943}. |
| O15117 | FYB1 | S46 | ochoa | FYN-binding protein 1 (Adhesion and degranulation promoting adaptor protein) (ADAP) (FYB-120/130) (p120/p130) (FYN-T-binding protein) (SLAP-130) (SLP-76-associated phosphoprotein) | Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells (By similarity). May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton (PubMed:10747096, PubMed:16980616). Modulates the expression of IL2 (By similarity). Involved in platelet activation (By similarity). Prevents the degradation of SKAP1 and SKAP2 (PubMed:15849195). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (By similarity). {ECO:0000250|UniProtKB:D3ZIE4, ECO:0000250|UniProtKB:O35601, ECO:0000269|PubMed:10747096, ECO:0000269|PubMed:15849195, ECO:0000269|PubMed:16980616}. |
| O15198 | SMAD9 | S323 | ochoa | Mothers against decapentaplegic homolog 9 (MAD homolog 9) (Mothers against DPP homolog 9) (Madh6) (SMAD family member 9) (SMAD 9) (Smad9) | Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD). |
| O15217 | GSTA4 | S189 | psp | Glutathione S-transferase A4 (EC 2.5.1.18) (GST class-alpha member 4) (Glutathione S-transferase A4-4) | Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4-hydroxynonenal (4-HNE). {ECO:0000269|PubMed:10329152, ECO:0000269|PubMed:20085333}. |
| O15523 | DDX3Y | S490 | ochoa | ATP-dependent RNA helicase DDX3Y (EC 3.6.4.13) (DEAD box protein 3, Y-chromosomal) | Probable ATP-dependent RNA helicase. During immune response, may enhance IFNB1 expression via IRF3/IRF7 pathway (By similarity). {ECO:0000250|UniProtKB:Q62095}. |
| O43189 | PHF1 | S420 | ochoa | PHD finger protein 1 (Protein PHF1) (hPHF1) (Polycomb-like protein 1) (hPCl1) | Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing spreading of PRC2 and H3K27me3 into H3K36me3 loci (PubMed:18285464, PubMed:23273982). According to another report, PHF1 recruits the PRC2 complex at double-strand breaks (DSBs) and inhibits the activity of PRC2 (PubMed:23142980). Regulates p53/TP53 stability and prolonges its turnover: may act by specifically binding to a methylated from of p53/TP53. {ECO:0000269|PubMed:18086877, ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:18385154, ECO:0000269|PubMed:23142980, ECO:0000269|PubMed:23150668, ECO:0000269|PubMed:23273982}. |
| O43294 | TGFB1I1 | S216 | ochoa | Transforming growth factor beta-1-induced transcript 1 protein (Androgen receptor coactivator 55 kDa protein) (Androgen receptor-associated protein of 55 kDa) (Hydrogen peroxide-inducible clone 5 protein) (Hic-5) | Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity. {ECO:0000269|PubMed:10075738, ECO:0000269|PubMed:11463817, ECO:0000269|PubMed:11856738, ECO:0000269|PubMed:12177201, ECO:0000269|PubMed:12445807, ECO:0000269|PubMed:12700349, ECO:0000269|PubMed:15211577, ECO:0000269|PubMed:15561701, ECO:0000269|PubMed:16141357, ECO:0000269|PubMed:16624805, ECO:0000269|PubMed:16803896, ECO:0000269|PubMed:16849583, ECO:0000269|PubMed:17166536, ECO:0000269|PubMed:17233630, ECO:0000269|PubMed:9032249}. |
| O43610 | SPRY3 | S108 | ochoa | Protein sprouty homolog 3 (Spry-3) (Sprouty RTK signaling antagonist 3) (Sprouty3) | Inhibits neurite branching, arbor length and neurite complexity (By similarity). Inhibits EGF-mediated p42/44 ERK signaling (By similarity). Negatively regulates the MAPK cascade, resulting in a reduction of extracellular matrix protein accumulation (PubMed:30878395). May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis (PubMed:9458049). {ECO:0000250|UniProtKB:Q3UUD2, ECO:0000269|PubMed:30878395, ECO:0000269|PubMed:9458049}. |
| O43613 | HCRTR1 | S262 | psp | Orexin/Hypocretin receptor type 1 (Hypocretin receptor type 1) (Orexin receptor type 1) (Ox-1-R) (Ox1-R) (Ox1R) | Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide (PubMed:26950369, PubMed:9491897). Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding (PubMed:26950369, PubMed:9491897). {ECO:0000269|PubMed:26950369, ECO:0000269|PubMed:9491897}. |
| O60333 | KIF1B | S1454 | ochoa | Kinesin-like protein KIF1B (Klp) (EC 5.6.1.3) | Has a plus-end-directed microtubule motor activity and functions as a motor for transport of vesicles and organelles along microtubules. {ECO:0000269|PubMed:16225668}.; FUNCTION: [Isoform 2]: Has a plus-end-directed microtubule motor activity and functions as a motor for anterograde synaptic vesicle transport along axonal microtubules from the cell body to the presynapse in neuronal cells (By similarity). Functions as a downstream effector in a developmental apoptotic pathway that is activated when nerve growth factor (NGF) becomes limiting for neuronal progenitor cells (PubMed:18334619). {ECO:0000250|UniProtKB:Q60575, ECO:0000269|PubMed:18334619}.; FUNCTION: [Isoform 3]: Has a plus-end-directed microtubule motor activity and functions as a motor for anterograde transport of mitochondria. {ECO:0000269|PubMed:16225668}. |
| O75030 | MITF | S414 | ochoa | Microphthalmia-associated transcription factor (Class E basic helix-loop-helix protein 32) (bHLHe32) | Transcription factor that acts as a master regulator of melanocyte survival and differentiation as well as melanosome biogenesis (PubMed:10587587, PubMed:22647378, PubMed:27889061, PubMed:9647758). Binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoter of pigmentation genes, such as tyrosinase (TYR) (PubMed:10587587, PubMed:22647378, PubMed:27889061, PubMed:9647758). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, MITF phosphorylation by MTOR promotes its inactivation (PubMed:36608670). Upon starvation or lysosomal stress, inhibition of MTOR induces MITF dephosphorylation, resulting in transcription factor activity (PubMed:36608670). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1) (PubMed:10587587, PubMed:22647378, PubMed:27889061, PubMed:9647758). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium (PubMed:10587587, PubMed:22647378, PubMed:27889061, PubMed:9647758). {ECO:0000269|PubMed:10587587, ECO:0000269|PubMed:22647378, ECO:0000269|PubMed:27889061, ECO:0000269|PubMed:36608670, ECO:0000269|PubMed:9647758}. |
| O75382 | TRIM3 | S427 | ochoa | Tripartite motif-containing protein 3 (EC 2.3.2.27) (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) | E3 ubiquitin ligase that plays essential roles in neuronal functions such as regulation of neuronal plasticity, learning, and memory (By similarity). In addition to its neuronal functions, participates in other biological processes such as innate immunity or cell cycle regulation. Component of the cytoskeleton-associated recycling or transport complex in neurons, polyubiquitinates gamma-actin, thus regulating neuronal plasticity, learning, and memory (By similarity). Ubiquitinates postsynaptic scaffold GKAP, a neuronal substrate involved in synaptic remodeling and thereby modulates dendritic spine morphology (By similarity). Positively regulates motility of microtubule-dependent motor protein KIF21B (By similarity). Induces growth arrest via its RING-dependent E3 ligase activity and ubiquinates CDKN1A (PubMed:24393003). Positively regulates TLR3-mediated signaling by mediating 'Lys-63'-linked polyubiquitination of TLR3 (PubMed:32878999). In turn, promotes the recognition and sorting of polyubiquitinated TLR3 by the ESCRT complexes (PubMed:32878999). {ECO:0000250|UniProtKB:Q9R1R2, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:24393003, ECO:0000269|PubMed:32878999}. |
| O75396 | SEC22B | S48 | ochoa | Vesicle-trafficking protein SEC22b (ER-Golgi SNARE of 24 kDa) (ERS-24) (ERS24) (SEC22 vesicle-trafficking protein homolog B) (SEC22 vesicle-trafficking protein-like 1) | SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER. {ECO:0000269|PubMed:15272311}. |
| O75420 | GIGYF1 | S863 | ochoa | GRB10-interacting GYF protein 1 (PERQ amino acid-rich with GYF domain-containing protein 1) | May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1 (By similarity). {ECO:0000250, ECO:0000269|PubMed:12771153}. |
| O75762 | TRPA1 | S86 | psp | Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Transformation-sensitive protein p120) (p120) (Wasabi receptor) | Ligand-activated Ca(2+)-permeable, nonselective cation channel involved in pain detection and possibly also in cold perception, oxygen concentration perception, cough, itch, and inner ear function (PubMed:17259981, PubMed:21195050, PubMed:21873995, PubMed:23199233, PubMed:25389312, PubMed:33152265). Has a relatively high Ca(2+) selectivity, with a preference for divalent over monovalent cations (Ca(2+) > Ba(2+) > Mg(2+) > NH4(+) > Li(+) > K(+)), the influx of cation into the cytoplasm leads to membrane depolarization (PubMed:19202543, PubMed:21195050). Has a central role in the pain response to endogenous inflammatory mediators, such as bradykinin and to a diverse array of irritants. Activated by a large variety of structurally unrelated electrophilic and non-electrophilic chemical compounds, such as allylthiocyanate (AITC) from mustard oil or wasabi, cinnamaldehyde, diallyl disulfide (DADS) from garlic, and acrolein, an environmental irritant (PubMed:20547126, PubMed:25389312, PubMed:27241698, PubMed:30878828). Electrophilic ligands activate TRPA1 by interacting with critical N-terminal Cys residues in a covalent manner (PubMed:17164327, PubMed:27241698, PubMed:31866091, PubMed:32641835). Non-electrophile agonists bind at distinct sites in the transmembrane domain to promote channel activation (PubMed:33152265). Also acts as an ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana (PubMed:25389312). May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds (By similarity). {ECO:0000250|UniProtKB:Q8BLA8, ECO:0000269|PubMed:17164327, ECO:0000269|PubMed:17259981, ECO:0000269|PubMed:19202543, ECO:0000269|PubMed:20547126, ECO:0000269|PubMed:21195050, ECO:0000269|PubMed:21873995, ECO:0000269|PubMed:23199233, ECO:0000269|PubMed:25389312, ECO:0000269|PubMed:27241698, ECO:0000269|PubMed:30878828, ECO:0000269|PubMed:31866091, ECO:0000269|PubMed:32641835, ECO:0000269|PubMed:33152265}. |
| O94880 | PHF14 | S29 | ochoa | PHD finger protein 14 | Histone-binding protein (PubMed:23688586). Binds preferentially to unmodified histone H3 but can also bind to a lesser extent to histone H3 trimethylated at 'Lys-9' (H3K9me3) as well as to histone H3 monomethylated at 'Lys-27' (H3K27ac) and trimethylated at 'Lys-27' (H3K27me3) (By similarity). Represses PDGFRA expression, thus playing a role in regulation of mesenchymal cell proliferation (By similarity). Suppresses the expression of CDKN1A/p21 by reducing the level of trimethylation of histone H3 'Lys-4', leading to enhanced proliferation of germinal center B cells (By similarity). {ECO:0000250|UniProtKB:A0A286Y9D1, ECO:0000250|UniProtKB:Q9D4H9, ECO:0000269|PubMed:23688586}. |
| O94915 | FRYL | S844 | ochoa | Protein furry homolog-like (ALL1-fused gene from chromosome 4p12 protein) | Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching (By similarity). May function as a transcriptional activator. {ECO:0000250, ECO:0000269|PubMed:16061630}. |
| O94955 | RHOBTB3 | S32 | ochoa | Rho-related BTB domain-containing protein 3 (EC 3.6.1.-) | Rab9-regulated ATPase required for endosome to Golgi transport. Involved in transport vesicle docking at the Golgi complex, possibly by participating in release M6PRBP1/TIP47 from vesicles to permit their efficient docking and fusion at the Golgi. Specifically binds Rab9, but not other Rab proteins. Has low intrinsic ATPase activity due to autoinhibition, which is relieved by Rab9. {ECO:0000269|PubMed:19490898}. |
| O94986 | CEP152 | S1461 | ochoa | Centrosomal protein of 152 kDa (Cep152) | Necessary for centrosome duplication; the function also seems to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). Acts as a molecular scaffold facilitating the interaction of PLK4 and CPAP, 2 molecules involved in centriole formation (PubMed:20852615, PubMed:21059844). Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure (PubMed:24997597). Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles (By similarity). Overexpression of CEP152 can drive amplification of centrioles (PubMed:20852615). {ECO:0000250|UniProtKB:A2AUM9, ECO:0000250|UniProtKB:Q498G2, ECO:0000269|PubMed:20852615, ECO:0000269|PubMed:21059844, ECO:0000269|PubMed:21131973}. |
| O95182 | NDUFA7 | S84 | ochoa | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 (Complex I-B14.5a) (CI-B14.5a) (NADH-ubiquinone oxidoreductase subunit B14.5a) | Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}. |
| O95202 | LETM1 | S142 | ochoa | Mitochondrial proton/calcium exchanger protein (Electroneutral mitochondrial K(+)/H(+)exchanger) (KHE) (Leucine zipper-EF-hand-containing transmembrane protein 1) | Plays an important role in maintenance of mitochondrial morphology and in mediating either calcium or potassium/proton antiport (PubMed:18628306, PubMed:19797662, PubMed:24344246, PubMed:24898248, PubMed:29123128, PubMed:32139798, PubMed:36055214, PubMed:36321428). Mediates proton-dependent calcium efflux from mitochondrion (PubMed:19797662, PubMed:24344246, PubMed:29123128). Also functions as an electroneutral mitochondrial proton/potassium exchanger (PubMed:24898248, PubMed:36055214, PubMed:36321428). Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain (PubMed:18628306, PubMed:36055214). Required for the maintenance of the tubular shape and cristae organization (PubMed:18628306, PubMed:32139798). {ECO:0000269|PubMed:18628306, ECO:0000269|PubMed:19797662, ECO:0000269|PubMed:24344246, ECO:0000269|PubMed:24898248, ECO:0000269|PubMed:29123128, ECO:0000269|PubMed:32139798, ECO:0000269|PubMed:36055214, ECO:0000269|PubMed:36321428}. |
| O95425 | SVIL | S467 | ochoa | Supervillin (Archvillin) (p205/p250) | [Isoform 1]: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699). Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (PubMed:19109420). {ECO:0000269|PubMed:12711699, ECO:0000269|PubMed:19109420}.; FUNCTION: [Isoform 2]: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity). {ECO:0000250|UniProtKB:O46385}. |
| O95478 | NSA2 | S205 | ochoa | Ribosome biogenesis protein NSA2 homolog (Hairy cell leukemia protein 1) (TGF-beta-inducible nuclear protein 1) | Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity). {ECO:0000250}. |
| O95613 | PCNT | S2177 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| O95833 | CLIC3 | S49 | ochoa | Chloride intracellular channel protein 3 (Glutaredoxin-like oxidoreductase CLIC3) (EC 1.8.-.-) | In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor (PubMed:28198360, PubMed:37759794). Reduced in a glutathione-dependent way and secreted into the extracellular matrix where it activates TGM2 and promotes blood vessel growth during tissue remodeling as occurs in tumorigenesis. Can reduce specific cysteines in TGM2 and regulate cofactor binding (PubMed:28198360). Can insert into membranes and form outwardly rectifying chloride ion channels. May participate in cellular growth control. {ECO:0000269|PubMed:28198360, ECO:0000269|PubMed:32066374, ECO:0000269|PubMed:37759794, ECO:0000269|PubMed:9880541}. |
| O95848 | NUDT14 | S144 | ochoa | Uridine diphosphate glucose pyrophosphatase NUDT14 (UDPG pyrophosphatase) (UGPPase) (EC 3.6.1.45) (Nucleoside diphosphate-linked moiety X motif 14) (Nudix motif 14) | Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose. |
| P04035 | HMGCR | S507 | ochoa | 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) (EC 1.1.1.34) | Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis (PubMed:21357570, PubMed:2991281, PubMed:36745799, PubMed:6995544). HMGCR is the main target of statins, a class of cholesterol-lowering drugs (PubMed:11349148, PubMed:18540668, PubMed:36745799). {ECO:0000269|PubMed:11349148, ECO:0000269|PubMed:18540668, ECO:0000269|PubMed:21357570, ECO:0000269|PubMed:2991281, ECO:0000269|PubMed:36745799, ECO:0000269|PubMed:6995544}. |
| P07339 | CTSD | S350 | ochoa | Cathepsin D (EC 3.4.23.5) [Cleaved into: Cathepsin D light chain; Cathepsin D heavy chain] | Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation (PubMed:27333034). Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. {ECO:0000269|PubMed:27333034}. |
| P09601 | HMOX1 | S229 | ochoa | Heme oxygenase 1 (HO-1) (EC 1.14.14.18) [Cleaved into: Heme oxygenase 1 soluble form] | [Heme oxygenase 1]: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron (PubMed:11121422, PubMed:19556236, PubMed:7703255). Affords protection against programmed cell death and this cytoprotective effect relies on its ability to catabolize free heme and prevent it from sensitizing cells to undergo apoptosis (PubMed:20055707). {ECO:0000269|PubMed:11121422, ECO:0000269|PubMed:19556236, ECO:0000269|PubMed:7703255, ECO:0000303|PubMed:20055707}.; FUNCTION: [Heme oxygenase 1]: (Microbial infection) During SARS-COV-2 infection, promotes SARS-CoV-2 ORF3A-mediated autophagy but is unlikely to be required for ORF3A-mediated induction of reticulophagy. {ECO:0000269|PubMed:35239449}.; FUNCTION: [Heme oxygenase 1 soluble form]: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. {ECO:0000269|PubMed:7703255}. |
| P10746 | UROS | S245 | ochoa | Uroporphyrinogen-III synthase (UROIIIS) (UROS) (EC 4.2.1.75) (Hydroxymethylbilane hydrolyase [cyclizing]) (Uroporphyrinogen-III cosynthase) | Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins (PubMed:11689424, PubMed:18004775). Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme) (PubMed:11689424, PubMed:18004775). {ECO:0000269|PubMed:11689424, ECO:0000269|PubMed:18004775}. |
| P14174 | MIF | S91 | psp | Macrophage migration inhibitory factor (MIF) (EC 5.3.2.1) (Glycosylation-inhibiting factor) (GIF) (L-dopachrome isomerase) (L-dopachrome tautomerase) (EC 5.3.3.12) (Phenylpyruvate tautomerase) | Pro-inflammatory cytokine involved in the innate immune response to bacterial pathogens (PubMed:15908412, PubMed:17443469, PubMed:23776208). The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense (PubMed:15908412, PubMed:17443469, PubMed:23776208). Counteracts the anti-inflammatory activity of glucocorticoids (PubMed:15908412, PubMed:17443469, PubMed:23776208). Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known (PubMed:11439086, PubMed:17526494). It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity (PubMed:11439086, PubMed:17526494). {ECO:0000269|PubMed:11439086, ECO:0000269|PubMed:15908412, ECO:0000269|PubMed:17443469, ECO:0000269|PubMed:17526494, ECO:0000269|PubMed:23776208}. |
| P15924 | DSP | S22 | ochoa | Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) | Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). {ECO:0000250|UniProtKB:F1LMV6}. |
| P16144 | ITGB4 | S1547 | ochoa | Integrin beta-4 (GP150) (CD antigen CD104) | Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:28873464}. |
| P19338 | NCL | S563 | ochoa | Nucleolin (Protein C23) | Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. {ECO:0000269|PubMed:10393184}. |
| P25054 | APC | S2350 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P28290 | ITPRID2 | S803 | ochoa | Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) | None |
| P28749 | RBL1 | S640 | ochoa|psp | Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (p107) (pRb1) | Key regulator of entry into cell division (PubMed:17671431). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation (By similarity). Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression (By similarity). Controls histone H4 'Lys-20' trimethylation (By similarity). Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters (By similarity). Potent inhibitor of E2F-mediated trans-activation (PubMed:8319904). May act as a tumor suppressor (PubMed:8319904). {ECO:0000250|UniProtKB:Q64701, ECO:0000269|PubMed:17671431, ECO:0000269|PubMed:8319904}. |
| P30043 | BLVRB | S82 | ochoa | Flavin reductase (NADPH) (FR) (EC 1.5.1.30) (Biliverdin reductase B) (BVR-B) (EC 1.3.1.-) (Biliverdin-IX beta-reductase) (Green heme-binding protein) (GHBP) (NADPH-dependent diaphorase) (NADPH-flavin reductase) (FLR) (S-nitroso-CoA-assisted nitrosyltransferase) (SNO-CoA-assisted nitrosyltransferase) (EC 2.6.99.-) | Enzyme that can both act as a NAD(P)H-dependent reductase and a S-nitroso-CoA-dependent nitrosyltransferase (PubMed:10620517, PubMed:18241201, PubMed:27207795, PubMed:38056462, PubMed:7929092). Promotes fetal heme degradation during development (PubMed:10858451, PubMed:18241201, PubMed:7929092). Also expressed in adult tissues, where it acts as a regulator of hematopoiesis, intermediary metabolism (glutaminolysis, glycolysis, TCA cycle and pentose phosphate pathway) and insulin signaling (PubMed:27207795, PubMed:29500232, PubMed:38056462). Has a broad specificity oxidoreductase activity by catalyzing the NAD(P)H-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone) (PubMed:10620517, PubMed:18241201, PubMed:7929092). Contributes to fetal heme catabolism by catalyzing reduction of biliverdin IXbeta into bilirubin IXbeta in the liver (PubMed:10858451, PubMed:18241201, PubMed:7929092). Biliverdin IXbeta, which constitutes the major heme catabolite in the fetus is not present in adult (PubMed:10858451, PubMed:18241201, PubMed:7929092). Does not reduce bilirubin IXalpha (PubMed:10858451, PubMed:18241201, PubMed:7929092). Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH (PubMed:10620517). Acts as a protein nitrosyltransferase by catalyzing nitrosylation of cysteine residues of target proteins, such as HMOX2, INSR and IRS1 (PubMed:38056462). S-nitroso-CoA-dependent nitrosyltransferase activity is mediated via a 'ping-pong' mechanism: BLVRB first associates with both S-nitroso-CoA and protein substrate, nitric oxide group is then transferred from S-nitroso-CoA to Cys-109 and Cys-188 residues of BLVRB and from S-nitroso-BLVRB to the protein substrate (PubMed:38056462). Inhibits insulin signaling by mediating nitrosylation of INSR and IRS1, leading to their inhibition (PubMed:38056462). {ECO:0000269|PubMed:10620517, ECO:0000269|PubMed:10858451, ECO:0000269|PubMed:18241201, ECO:0000269|PubMed:27207795, ECO:0000269|PubMed:29500232, ECO:0000269|PubMed:38056462, ECO:0000269|PubMed:7929092}. |
| P30304 | CDC25A | S116 | ochoa|psp | M-phase inducer phosphatase 1 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25A) | Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression (PubMed:12676925, PubMed:14559997, PubMed:1836978, PubMed:20360007). Directly dephosphorylates CDK1 and stimulates its kinase activity (PubMed:20360007). Also dephosphorylates CDK2 in complex with cyclin-E, in vitro (PubMed:20360007). {ECO:0000269|PubMed:12676925, ECO:0000269|PubMed:14559997, ECO:0000269|PubMed:1836978, ECO:0000269|PubMed:20360007}. |
| P30626 | SRI | S137 | ochoa | Sorcin (22 kDa protein) (CP-22) (CP22) (V19) | Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels. {ECO:0000269|PubMed:17699613}. |
| P31629 | HIVEP2 | S71 | ochoa | Transcription factor HIVEP2 (Human immunodeficiency virus type I enhancer-binding protein 2) (HIV-EP2) (MHC-binding protein 2) (MBP-2) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation. |
| P36776 | LONP1 | S548 | ochoa | Lon protease homolog, mitochondrial (EC 3.4.21.53) (LONHs) (Lon protease-like protein) (LONP) (Mitochondrial ATP-dependent protease Lon) (Serine protease 15) | ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix (PubMed:12198491, PubMed:15870080, PubMed:17579211, PubMed:37327776, PubMed:8248235). Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein, DELE1, helicase Twinkle (TWNK) and the large ribosomal subunit protein MRPL32/bL32m (PubMed:17579211, PubMed:28377575, PubMed:37327776). MRPL32/bL32m is protected from degradation by LONP1 when it is bound to a nucleic acid (RNA), but TWNK is not (PubMed:17579211, PubMed:28377575). May also have a chaperone function in the assembly of inner membrane protein complexes (By similarity). Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome (PubMed:17420247). Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner (PubMed:17420247). May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters (PubMed:14739292, PubMed:17420247). {ECO:0000255|HAMAP-Rule:MF_03120, ECO:0000269|PubMed:12198491, ECO:0000269|PubMed:14739292, ECO:0000269|PubMed:15870080, ECO:0000269|PubMed:17420247, ECO:0000269|PubMed:17579211, ECO:0000269|PubMed:28377575, ECO:0000269|PubMed:37327776, ECO:0000269|PubMed:8248235}. |
| P38398 | BRCA1 | S1613 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P42694 | HELZ | S1247 | ochoa | Probable helicase with zinc finger domain (EC 3.6.4.-) (Down-regulated in human cancers protein) | May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo. |
| P43490 | NAMPT | S398 | ochoa | Nicotinamide phosphoribosyltransferase (NAmPRTase) (Nampt) (EC 2.4.2.12) (Pre-B-cell colony-enhancing factor 1) (Pre-B cell-enhancing factor) (Visfatin) | Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity). {ECO:0000250|UniProtKB:Q99KQ4, ECO:0000269|PubMed:24130902}. |
| P46089 | GPR3 | S237 | psp | G-protein coupled receptor 3 (ACCA orphan receptor) | Constitutively active G-protein coupled receptor that maintains high 3'-5'-cyclic adenosine monophosphate (cAMP) levels that a plays a role in serveral processes including meiotic arrest in oocytes or neuronal development via activation of numerous intracellular signaling pathways. Acts as an essential activator of thermogenic adipocytes and drives thermogenesis via its intrinsic G(s)-coupling activity without the requirement of a ligand (PubMed:34048700). Has a potential role in modulating a number of brain functions, including behavioral responses to stress (By similarity), amyloid-beta peptide generation in neurons (By similarity). Stimulates neurite outgrowth in cerebellar granular neurons modulated via PKA, ERK, and most strongly PI3K-mediated signaling pathways (By similarity). {ECO:0000250|UniProtKB:P35413, ECO:0000269|PubMed:19213921, ECO:0000269|PubMed:34048700}. |
| P46821 | MAP1B | S1666 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P46934 | NEDD4 | S467 | ochoa | E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates 'Lys-63' in target proteins (PubMed:19920177, PubMed:21399620, PubMed:23644597). Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes (By similarity). Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes (PubMed:21765395). Promotes ubiquitination of RAPGEF2 (PubMed:11598133). According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD (By similarity). Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development (By similarity). Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2 (PubMed:20086093). Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Ubiquitinates DAZAP2, leading to its proteasomal degradation (PubMed:11342538). Ubiquitinates POLR2A (PubMed:19920177). Functions as a platform to recruit USP13 to form an NEDD4-USP13 deubiquitination complex that plays a critical role in cleaving the 'Lys-48'-linked ubiquitin chains of VPS34 and then stabilizing VPS34, thus promoting the formation of autophagosomes (PubMed:32101753). {ECO:0000250|UniProtKB:P46935, ECO:0000269|PubMed:11342538, ECO:0000269|PubMed:11598133, ECO:0000269|PubMed:17218260, ECO:0000269|PubMed:18562292, ECO:0000269|PubMed:21399620, ECO:0000269|PubMed:21765395, ECO:0000269|PubMed:23644597, ECO:0000269|PubMed:25631046, ECO:0000269|PubMed:32101753}.; FUNCTION: (Microbial infection) Involved in the ubiquitination of Ebola virus protein VP40 which plays a role in viral budding. {ECO:0000269|PubMed:12559917, ECO:0000269|PubMed:18305167}. |
| P46940 | IQGAP1 | S86 | ochoa | Ras GTPase-activating-like protein IQGAP1 (p195) | Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Recruited to the cell cortex by interaction with ILK which allows it to cooperate with its effector DIAPH1 to locally stabilize microtubules and allow stable insertion of caveolae into the plasma membrane (By similarity). Binds to activated CDC42 but does not stimulate its GTPase activity. Associates with calmodulin. May promote neurite outgrowth (PubMed:15695813). May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest (PubMed:20883816). {ECO:0000250|UniProtKB:Q9JKF1, ECO:0000269|PubMed:15695813, ECO:0000269|PubMed:20883816}. |
| P47900 | P2RY1 | S252 | psp | P2Y purinoceptor 1 (P2Y1) (ADP receptor) (Purinergic receptor) | Receptor for extracellular adenine nucleotides such as ADP (PubMed:25822790, PubMed:9038354, PubMed:9442040). In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately platelet aggregation (PubMed:9442040). {ECO:0000269|PubMed:25822790, ECO:0000269|PubMed:9038354, ECO:0000269|PubMed:9442040}. |
| P48552 | NRIP1 | S218 | ochoa | Nuclear receptor-interacting protein 1 (Nuclear factor RIP140) (Receptor-interacting protein 140) | Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function (By similarity). Plays a role in renal development (PubMed:28381549). {ECO:0000250|UniProtKB:Q8CBD1, ECO:0000269|PubMed:10364267, ECO:0000269|PubMed:11509661, ECO:0000269|PubMed:11518808, ECO:0000269|PubMed:12554755, ECO:0000269|PubMed:15060175, ECO:0000269|PubMed:21628546, ECO:0000269|PubMed:28381549, ECO:0000269|PubMed:7641693}. |
| P49116 | NR2C2 | S328 | ochoa | Nuclear receptor subfamily 2 group C member 2 (Orphan nuclear receptor TAK1) (Orphan nuclear receptor TR4) (Testicular receptor 4) | Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation. {ECO:0000250, ECO:0000269|PubMed:10347174, ECO:0000269|PubMed:10644740, ECO:0000269|PubMed:17974920, ECO:0000269|PubMed:7779113, ECO:0000269|PubMed:9556573}. |
| P50747 | HLCS | S147 | ochoa | Biotin--protein ligase (EC 6.3.4.-) (Biotin apo-protein ligase) [Includes: Biotin--[methylmalonyl-CoA-carboxytransferase] ligase (EC 6.3.4.9); Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase (EC 6.3.4.10) (Holocarboxylase synthetase) (HCS); Biotin--[methylcrotonoyl-CoA-carboxylase] ligase (EC 6.3.4.11); Biotin--[acetyl-CoA-carboxylase] ligase (EC 6.3.4.15)] | Biotin--protein ligase catalyzing the biotinylation of the 4 biotin-dependent carboxylases acetyl-CoA-carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, and methylcrotonyl-CoA carboxylase. {ECO:0000269|PubMed:10590022, ECO:0000269|PubMed:7753853, ECO:0000269|PubMed:7842009}. |
| P50993 | ATP1A2 | S496 | ochoa | Sodium/potassium-transporting ATPase subunit alpha-2 (Na(+)/K(+) ATPase alpha-2 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-2) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients. {ECO:0000269|PubMed:33880529}. |
| P51531 | SMARCA2 | S329 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 (SAMRCA2) (EC 3.6.4.-) (BRG1-associated factor 190B) (BAF190B) (Probable global transcription activator SNF2L2) (Protein brahma homolog) (hBRM) (SNF2-alpha) | ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically (PubMed:15075294, PubMed:22952240, PubMed:26601204). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:Q6DIC0, ECO:0000269|PubMed:15075294, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| P51608 | MECP2 | S229 | ochoa|psp | Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2) | Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). {ECO:0000250|UniProtKB:Q9Z2D6}. |
| P51957 | NEK4 | S484 | ochoa | Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) | Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage. {ECO:0000250|UniProtKB:Q9Z1J2, ECO:0000269|PubMed:22851694}. |
| P55273 | CDKN2D | S66 | psp | Cyclin-dependent kinase 4 inhibitor D (p19-INK4d) | Interacts strongly with CDK4 and CDK6 and inhibits them. {ECO:0000269|PubMed:7739548, ECO:0000269|PubMed:8741839}. |
| P63279 | UBE2I | S71 | ochoa|psp | SUMO-conjugating enzyme UBC9 (EC 2.3.2.-) (RING-type E3 SUMO transferase UBC9) (SUMO-protein ligase) (Ubiquitin carrier protein 9) (Ubiquitin carrier protein I) (Ubiquitin-conjugating enzyme E2 I) (Ubiquitin-protein ligase I) (p18) | Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3, SUMO4 and SUMO1P1/SUMO5 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451. Can catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at 'Lys-386'. Mediates sumoylation of ERCC6 which is essential for its transcription-coupled nucleotide excision repair activity (PubMed:26620705). {ECO:0000269|PubMed:11451954, ECO:0000269|PubMed:15809060, ECO:0000269|PubMed:17466333, ECO:0000269|PubMed:19638400, ECO:0000269|PubMed:19744555, ECO:0000269|PubMed:20077568, ECO:0000269|PubMed:26524494, ECO:0000269|PubMed:26620705, ECO:0000269|PubMed:27211601, ECO:0000269|PubMed:8668529}. |
| P78559 | MAP1A | S909 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| P86452 | ZBED6 | S381 | ochoa | Zinc finger BED domain-containing protein 6 | Transcriptional repressor which binds to the consensus sequence 5'-GCTCGC-3', transcription regulation may be tissue-specific (By similarity). Regulates the expression of target genes such as: IGF2, PGAP6/TMEM8, ENHO, and PIANP (By similarity). Acts as a transcriptional repressor of growth factor IGF2, thereby negatively regulating postnatal growth of muscles and internal organs, especially in females (By similarity). Negatively regulates myoblast differentiation and myoblast mitochondrial activity via its regulation of IGF2 transcription (By similarity). Negatively regulates the cell cycle of myoblasts, potentially via transcriptional regulation of the E2F family of transcription factors such as: E2F1 and E2F2 (By similarity). Positively regulates the cell cycle and survival of pancreatic beta cells (PubMed:24043816). Binds to the CDH2 gene and may directly repress CDH2 transcription (By similarity). Probably by controlling CDH2 expression, regulates pancreatic beta cell adhesion, and formation of cell-to-cell junctions between pancreatic beta cells and neural crest stem cells (By similarity). May also play a role in embryonic beta cell differentiation (By similarity). May play a role in insulin sensitivity and glucose clearance (By similarity). {ECO:0000250|UniProtKB:D2EAC2, ECO:0000269|PubMed:24043816}. |
| P98160 | HSPG2 | S2986 | ochoa | Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG) (Perlecan) (PLC) [Cleaved into: Endorepellin; LG3 peptide] | Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development.; FUNCTION: [Endorepellin]: Anti-angiogenic and anti-tumor peptide that inhibits endothelial cell migration, collagen-induced endothelial tube morphogenesis and blood vessel growth in the chorioallantoic membrane. Blocks endothelial cell adhesion to fibronectin and type I collagen. Anti-tumor agent in neovascularization. Interaction with its ligand, integrin alpha2/beta1, is required for the anti-angiogenic properties. Evokes a reduction in phosphorylation of receptor tyrosine kinases via alpha2/beta1 integrin-mediated activation of the tyrosine phosphatase, PTPN6.; FUNCTION: [LG3 peptide]: Has anti-angiogenic properties that require binding of calcium ions for full activity. |
| Q02880 | TOP2B | S1400 | ochoa | DNA topoisomerase 2-beta (EC 5.6.2.2) (DNA topoisomerase II, beta isozyme) | Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Plays a role in B-cell differentiation. {ECO:0000269|PubMed:10684600, ECO:0000269|PubMed:31409799, ECO:0000269|PubMed:32128574}. |
| Q05519 | SRSF11 | S70 | ochoa | Serine/arginine-rich splicing factor 11 (Arginine-rich 54 kDa nuclear protein) (p54) (Splicing factor, arginine/serine-rich 11) | May function in pre-mRNA splicing. |
| Q08J23 | NSUN2 | S139 | psp | RNA cytosine C(5)-methyltransferase NSUN2 (EC 2.1.1.-) (Myc-induced SUN domain-containing protein) (Misu) (NOL1/NOP2/Sun domain family member 2) (Substrate of AIM1/Aurora kinase B) (mRNA cytosine C(5)-methyltransferase) (EC 2.1.1.-) (tRNA cytosine C(5)-methyltransferase) (EC 2.1.1.-, EC 2.1.1.203) (tRNA methyltransferase 4 homolog) (hTrm4) | RNA cytosine C(5)-methyltransferase that methylates cytosine to 5-methylcytosine (m5C) in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs) (PubMed:17071714, PubMed:22995836, PubMed:31199786, PubMed:31358969). Involved in various processes, such as epidermal stem cell differentiation, testis differentiation and maternal to zygotic transition during early development: acts by increasing protein synthesis; cytosine C(5)-methylation promoting tRNA stability and preventing mRNA decay (PubMed:31199786). Methylates cytosine to 5-methylcytosine (m5C) at positions 34 and 48 of intron-containing tRNA(Leu)(CAA) precursors, and at positions 48, 49 and 50 of tRNA(Gly)(GCC) precursors (PubMed:17071714, PubMed:22995836, PubMed:31199786). tRNA methylation is required generation of RNA fragments derived from tRNAs (tRFs) (PubMed:31199786). Also mediates C(5)-methylation of mitochondrial tRNAs (PubMed:31276587). Catalyzes cytosine C(5)-methylation of mRNAs, leading to stabilize them and prevent mRNA decay: mRNA stabilization involves YBX1 that specifically recognizes and binds m5C-modified transcripts (PubMed:22395603, PubMed:31358969, PubMed:34556860). Cytosine C(5)-methylation of mRNAs also regulates mRNA export: methylated transcripts are specifically recognized by THOC4/ALYREF, which mediates mRNA nucleo-cytoplasmic shuttling (PubMed:28418038). Also mediates cytosine C(5)-methylation of non-coding RNAs, such as vault RNAs (vtRNAs), promoting their processing into regulatory small RNAs (PubMed:23871666). Cytosine C(5)-methylation of vtRNA VTRNA1.1 promotes its processing into small-vault RNA4 (svRNA4) and regulates epidermal differentiation (PubMed:31186410). May act downstream of Myc to regulate epidermal cell growth and proliferation (By similarity). Required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity (PubMed:19596847). {ECO:0000250|UniProtKB:Q1HFZ0, ECO:0000269|PubMed:17071714, ECO:0000269|PubMed:19596847, ECO:0000269|PubMed:22395603, ECO:0000269|PubMed:22995836, ECO:0000269|PubMed:23871666, ECO:0000269|PubMed:28418038, ECO:0000269|PubMed:31186410, ECO:0000269|PubMed:31199786, ECO:0000269|PubMed:31276587, ECO:0000269|PubMed:31358969, ECO:0000269|PubMed:34556860}. |
| Q12756 | KIF1A | S1337 | ochoa | Kinesin-like protein KIF1A (EC 5.6.1.3) (Axonal transporter of synaptic vesicles) (Microtubule-based motor KIF1A) (Unc-104- and KIF1A-related protein) (hUnc-104) | Kinesin motor with a plus-end-directed microtubule motor activity (By similarity). It is required for anterograde axonal transport of synaptic vesicle precursors (PubMed:33880452). Also required for neuronal dense core vesicles (DCVs) transport to the dendritic spines and axons. The interaction calcium-dependent with CALM1 increases vesicle motility and interaction with the scaffolding proteins PPFIA2 and TANC2 recruits DCVs to synaptic sites. {ECO:0000250|UniProtKB:F1M4A4, ECO:0000250|UniProtKB:P33173, ECO:0000269|PubMed:33880452}. |
| Q12778 | FOXO1 | S383 | psp | Forkhead box protein O1 (Forkhead box protein O1A) (Forkhead in rhabdomyosarcoma) | Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress (PubMed:10358076, PubMed:12228231, PubMed:15220471, PubMed:15890677, PubMed:18356527, PubMed:19221179, PubMed:20543840, PubMed:21245099). Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3' (PubMed:10358076). Activity suppressed by insulin (PubMed:10358076). Main regulator of redox balance and osteoblast numbers and controls bone mass (By similarity). Orchestrates the endocrine function of the skeleton in regulating glucose metabolism (By similarity). Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity (By similarity). Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP (By similarity). Acts as an inhibitor of glucose sensing in pancreatic beta cells by acting as a transcription repressor and suppressing expression of PDX1 (By similarity). In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC1 and PCK1 (By similarity). Also promotes gluconeogenesis by directly promoting expression of PPARGC1A and G6PC1 (PubMed:17024043). Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and STK4/MST1 (PubMed:18356527, PubMed:19221179). Promotes neural cell death (PubMed:18356527). Mediates insulin action on adipose tissue (By similarity). Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake (By similarity). Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells (By similarity). Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner (PubMed:20543840). Mediates the function of MLIP in cardiomyocytes hypertrophy and cardiac remodeling (By similarity). Positive regulator of apoptosis in cardiac smooth muscle cells as a result of its transcriptional activation of pro-apoptotic genes (PubMed:19483080). Regulates endothelial cell (EC) viability and apoptosis in a PPIA/CYPA-dependent manner via transcription of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (PubMed:31063815). {ECO:0000250|UniProtKB:A4L7N3, ECO:0000250|UniProtKB:G3V7R4, ECO:0000250|UniProtKB:Q9R1E0, ECO:0000269|PubMed:10358076, ECO:0000269|PubMed:12228231, ECO:0000269|PubMed:15220471, ECO:0000269|PubMed:15890677, ECO:0000269|PubMed:17024043, ECO:0000269|PubMed:18356527, ECO:0000269|PubMed:19221179, ECO:0000269|PubMed:19483080, ECO:0000269|PubMed:20543840, ECO:0000269|PubMed:21245099, ECO:0000269|PubMed:31063815}. |
| Q13009 | TIAM1 | S1532 | ochoa | Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1) | Guanyl-nucleotide exchange factor that activates RHO-like proteins and connects extracellular signals to cytoskeletal activities. Activates RAC1, CDC42, and to a lesser extent RHOA and their downstream signaling to regulate processes like cell adhesion and cell migration. {ECO:0000269|PubMed:20361982, ECO:0000269|PubMed:25684205}. |
| Q13085 | ACACA | S50 | ochoa | Acetyl-CoA carboxylase 1 (ACC1) (EC 6.4.1.2) (Acetyl-Coenzyme A carboxylase alpha) (ACC-alpha) | Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis (PubMed:20457939, PubMed:20952656, PubMed:29899443). This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:20457939, PubMed:20952656, PubMed:29899443). {ECO:0000269|PubMed:20457939, ECO:0000269|PubMed:20952656, ECO:0000269|PubMed:29899443}. |
| Q13370 | PDE3B | S22 | ochoa | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B (EC 3.1.4.17) (CGIPDE1) (CGIP1) (Cyclic GMP-inhibited phosphodiesterase B) (CGI-PDE B) | Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological process (PubMed:14592490, PubMed:21393242). Regulates angiogenesis by inhibiting the cAMP-dependent guanine nucleotide exchange factor RAPGEF3 and downstream phosphatidylinositol 3-kinase gamma-mediated signaling (PubMed:21393242). Controls cardiac contractility by reducing cAMP concentration in cardiocytes (By similarity). {ECO:0000250|UniProtKB:Q61409, ECO:0000269|PubMed:14592490, ECO:0000269|PubMed:21393242}. |
| Q13637 | RAB32 | S154 | ochoa | Ras-related protein Rab-32 (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:11784320, PubMed:21808068). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:11784320). Also acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission (PubMed:12186851). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211). Plays an important role in the control of melanin production and melanosome biogenesis (PubMed:23084991). In concert with RAB38, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity). Stimulates phosphorylation of RAB10 'Thr-73' by LRRK2 (PubMed:38127736). {ECO:0000250|UniProtKB:Q9CZE3, ECO:0000269|PubMed:11784320, ECO:0000269|PubMed:12186851, ECO:0000269|PubMed:21255211, ECO:0000269|PubMed:21808068, ECO:0000269|PubMed:23084991, ECO:0000269|PubMed:38127736}. |
| Q14157 | UBAP2L | S95 | ochoa | Ubiquitin-associated protein 2-like (Protein NICE-4) (RNA polymerase II degradation factor UBAP2L) | Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs) (By similarity). Is a regulator of stress granule assembly, required for their efficient formation (PubMed:29395067, PubMed:35977029). Required for proper brain development and neocortex lamination (By similarity). {ECO:0000250|UniProtKB:Q80X50, ECO:0000269|PubMed:29395067, ECO:0000269|PubMed:35633597}. |
| Q14324 | MYBPC2 | S1111 | ochoa | Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform) | Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. |
| Q14558 | PRPSAP1 | S215 | ochoa | Phosphoribosyl pyrophosphate synthase-associated protein 1 (PRPP synthase-associated protein 1) (39 kDa phosphoribosypyrophosphate synthase-associated protein) (PAP39) | Seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis. |
| Q14966 | ZNF638 | S605 | ochoa | Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein) | Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:30487602, PubMed:8647861). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q61464, ECO:0000269|PubMed:30487602, ECO:0000269|PubMed:8647861}. |
| Q15067 | ACOX1 | S26 | ochoa|psp | Peroxisomal acyl-coenzyme A oxidase 1 (AOX) (EC 1.3.3.6) (Palmitoyl-CoA oxidase) (Peroxisomal fatty acyl-CoA oxidase) (Straight-chain acyl-CoA oxidase) (SCOX) [Cleaved into: Peroxisomal acyl-CoA oxidase 1, A chain; Peroxisomal acyl-CoA oxidase 1, B chain; Peroxisomal acyl-CoA oxidase 1, C chain] | Involved in the initial and rate-limiting step of peroxisomal beta-oxidation of straight-chain saturated and unsaturated very-long-chain fatty acids (PubMed:15060085, PubMed:17458872, PubMed:17603022, PubMed:32169171, PubMed:33234382, PubMed:7876265). Catalyzes the desaturation of fatty acyl-CoAs such as palmitoyl-CoA (hexadecanoyl-CoA) to 2-trans-enoyl-CoAs ((2E)-enoyl-CoAs) such as (2E)-hexadecenoyl-CoA, and donates electrons directly to molecular oxygen (O(2)), thereby producing hydrogen peroxide (H(2)O(2)) (PubMed:17458872, PubMed:17603022, PubMed:7876265). {ECO:0000269|PubMed:15060085, ECO:0000269|PubMed:17458872, ECO:0000269|PubMed:17603022, ECO:0000269|PubMed:32169171, ECO:0000269|PubMed:33234382, ECO:0000269|PubMed:7876265}.; FUNCTION: [Isoform 1]: Shows highest activity against medium-chain fatty acyl-CoAs. Shows optimum activity with a chain length of 10 carbons (decanoyl-CoA) in vitro. {ECO:0000269|PubMed:17603022}.; FUNCTION: [Isoform 2]: Is active against a much broader range of substrates and shows activity towards long-chain fatty acyl-CoAs. {ECO:0000269|PubMed:17603022}. |
| Q15650 | TRIP4 | S387 | ochoa | Activating signal cointegrator 1 (ASC-1) (Thyroid receptor-interacting protein 4) (TR-interacting protein 4) (TRIP-4) | Transcription coactivator which associates with nuclear receptors, transcriptional coactivators including EP300, CREBBP and NCOA1, and basal transcription factors like TBP and TFIIA to facilitate nuclear receptors-mediated transcription (PubMed:10454579, PubMed:25219498). May thereby play an important role in establishing distinct coactivator complexes under different cellular conditions (PubMed:10454579, PubMed:25219498). Plays a role in thyroid hormone receptor and estrogen receptor transactivation (PubMed:10454579, PubMed:25219498). Also involved in androgen receptor transactivation (By similarity). Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1 (PubMed:12077347). Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF-kappa-B (PubMed:12077347). May play a role in the development of neuromuscular junction (PubMed:26924529). May play a role in late myogenic differentiation (By similarity). Also functions as part of the RQC trigger (RQT) complex that activates the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation (PubMed:32099016, PubMed:32579943, PubMed:36302773). {ECO:0000250|UniProtKB:Q9QXN3, ECO:0000269|PubMed:10454579, ECO:0000269|PubMed:12077347, ECO:0000269|PubMed:25219498, ECO:0000269|PubMed:26924529, ECO:0000269|PubMed:32099016, ECO:0000269|PubMed:32579943, ECO:0000269|PubMed:36302773}. |
| Q15697 | ZNF174 | S195 | ochoa | Zinc finger protein 174 (AW-1) (Zinc finger and SCAN domain-containing protein 8) | Transcriptional repressor. {ECO:0000269|PubMed:7673192}. |
| Q15797 | SMAD1 | S321 | ochoa | Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1) | Transcriptional modulator that plays a role in various cellular processes, including embryonic development, cell differentiation, and tissue homeostasis (PubMed:9335504). Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD4 to form a heteromeric complex which translocates into the nucleus acting as transcription factor (PubMed:33667543). In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network (PubMed:33667543). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Positively regulates BMP4-induced expression of odontogenic development regulator MSX1 following IPO7-mediated nuclear import (By similarity). {ECO:0000250|UniProtKB:P70340, ECO:0000269|PubMed:12097147, ECO:0000269|PubMed:33667543, ECO:0000269|PubMed:9335504}. |
| Q16690 | DUSP5 | S346 | psp | Dual specificity protein phosphatase 5 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH3) | Dual specificity protein phosphatase; active with phosphotyrosine, phosphoserine and phosphothreonine residues. The highest relative activity is toward ERK1. {ECO:0000269|PubMed:7961985}. |
| Q16763 | UBE2S | S73 | ochoa | Ubiquitin-conjugating enzyme E2 S (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme S) (E2-EPF) (Ubiquitin carrier protein S) (Ubiquitin-conjugating enzyme E2-24 kDa) (Ubiquitin-conjugating enzyme E2-EPF5) (Ubiquitin-protein ligase S) | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:19820702, PubMed:19822757, PubMed:22496338, PubMed:27259151). Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis (PubMed:19820702, PubMed:19822757, PubMed:27259151, PubMed:27910872). Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit (PubMed:19820702, PubMed:19822757, PubMed:27259151). Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as an E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A (PubMed:16819549). In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination (PubMed:20061386, PubMed:20622874). {ECO:0000269|PubMed:16819549, ECO:0000269|PubMed:19820702, ECO:0000269|PubMed:19822757, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:20622874, ECO:0000269|PubMed:22496338, ECO:0000269|PubMed:27259151, ECO:0000269|PubMed:27910872}. |
| Q24JP5 | TMEM132A | S913 | ochoa | Transmembrane protein 132A (HSPA5-binding protein 1) | May play a role in embryonic and postnatal development of the brain. Increased resistance to cell death induced by serum starvation in cultured cells. Regulates cAMP-induced GFAP gene expression via STAT3 phosphorylation (By similarity). {ECO:0000250}. |
| Q29RF7 | PDS5A | S1149 | ochoa | Sister chromatid cohesion protein PDS5 homolog A (Cell proliferation-inducing gene 54 protein) (Sister chromatid cohesion protein 112) (SCC-112) | Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15855230, ECO:0000269|PubMed:19907496}. |
| Q2TAK8 | PWWP3A | S235 | ochoa | PWWP domain-containing DNA repair factor 3A (PWWP3A) (Mutated melanoma-associated antigen 1) (MUM-1) (PWWP domain-containing protein MUM1) (Protein expandere) | Involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. Recruited to the vicinity of DNA breaks by TP53BP1 and plays an accessory role to facilitate damage-induced chromatin changes and promoting chromatin relaxation. Required for efficient DNA repair and cell survival following DNA damage. {ECO:0000269|PubMed:20347427}. |
| Q3KR16 | PLEKHG6 | S537 | ochoa | Pleckstrin homology domain-containing family G member 6 (PH domain-containing family G member 6) (Myosin-interacting guanine nucleotide exchange factor) (MyoGEF) | Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Also activates RHOG. Does not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving PLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis. {ECO:0000269|PubMed:16721066, ECO:0000269|PubMed:17881735}. |
| Q53RY4 | KRTCAP3 | S214 | ochoa | Keratinocyte-associated protein 3 (KCP-3) | None |
| Q5FBB7 | SGO1 | S468 | ochoa | Shugoshin 1 (Serologically defined breast cancer antigen NY-BR-85) (Shugoshin-like 1) | Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity. Involved in centromeric enrichment of AUKRB in prometaphase. {ECO:0000269|PubMed:15604152, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:15737064, ECO:0000269|PubMed:16580887, ECO:0000269|PubMed:17617734, ECO:0000269|PubMed:17621308, ECO:0000269|PubMed:18331714, ECO:0000269|PubMed:20739936}. |
| Q5FWF5 | ESCO1 | S200 | ochoa | N-acetyltransferase ESCO1 (EC 2.3.1.-) (CTF7 homolog 1) (Establishment factor-like protein 1) (EFO1) (EFO1p) (hEFO1) (Establishment of cohesion 1 homolog 1) (ECO1 homolog 1) (ESO1 homolog 1) | Acetyltransferase required for the establishment of sister chromatid cohesion (PubMed:15958495, PubMed:18614053). Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by mediating the acetylation of cohesin component SMC3 (PubMed:18614053). {ECO:0000269|PubMed:14576321, ECO:0000269|PubMed:15958495, ECO:0000269|PubMed:18614053, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:27112597, ECO:0000269|PubMed:27803161}. |
| Q5H8A4 | PIGG | S639 | ochoa | GPI ethanolamine phosphate transferase 2, catalytic subunit (EC 2.-.-.-) (GPI7 homolog) (hGPI7) (Phosphatidylinositol-glycan biosynthesis class G protein) (PIG-G) | Catalytic subunit of the ethanolamine phosphate transferase 2 complex that transfers an ethanolamine phosphate (EtNP) from a phosphatidylethanolamine (PE) to the 6-OH position of the second alpha-1,6-linked mannose of a 6-PEtn-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-2-PEtn-alpha-D-Man-(1->4)-alpha-D-GlcN-(1->6)-(1-radyl,2-acyl-sn-glycero-3-phospho)-2-acyl-inositol (also termed H7) intermediate to generate a 6-PEtn-alpha-D-Man-(1->2)-6-PEtn-alpha-D-Man-(1->6)-2-PEtn-alpha-D-Man-(1->4)-alpha-D-GlcN-(1->6)-(1-radyl,2-acyl-sn-glycero-3-phospho)-2-acyl-inositol (also termed H8) and participates in the eleventh step of the glycosylphosphatidylinositol-anchor biosynthesis. {ECO:0000269|PubMed:15632136, ECO:0000269|PubMed:26996948, ECO:0000269|PubMed:33763700, ECO:0000269|PubMed:34113002}. |
| Q5T4S7 | UBR4 | S4117 | ochoa | E3 ubiquitin-protein ligase UBR4 (EC 2.3.2.27) (600 kDa retinoblastoma protein-associated factor) (p600) (N-recognin-4) (Retinoblastoma-associated factor of 600 kDa) (RBAF600) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm (PubMed:25582440, PubMed:29033132, PubMed:34893540, PubMed:37891180, PubMed:38030679, PubMed:38182926, PubMed:38297121). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180, PubMed:38030679). Recognizes both type-1 and type-2 N-degrons, containing positively charged amino acids (Arg, Lys and His) and bulky and hydrophobic amino acids, respectively (PubMed:38030679). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR5, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR4 probably synthesizes mixed chains containing multiple linkages, while UBR5 is likely branching multiple 'Lys-48'-linked chains of substrates initially modified (PubMed:29033132). Together with KCMF1, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). Mediates ubiquitination of ACLY, leading to its subsequent degradation (PubMed:23932781). Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization (PubMed:16214886). {ECO:0000269|PubMed:16214886, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:25582440, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:37891180, ECO:0000269|PubMed:38030679, ECO:0000269|PubMed:38182926, ECO:0000269|PubMed:38297121}. |
| Q5T5P2 | KIAA1217 | S1684 | ochoa | Sickle tail protein homolog | Required for normal development of intervertebral disks. {ECO:0000250|UniProtKB:A2AQ25}. |
| Q5T7W0 | ZNF618 | S120 | ochoa | Zinc finger protein 618 | Regulates UHRF2 function as a specific 5-hydroxymethylcytosine (5hmC) reader by regulating its chromatin localization. {ECO:0000269|PubMed:27129234}. |
| Q5U651 | RASIP1 | S188 | ochoa | Ras-interacting protein 1 (Rain) | Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells (By similarity). May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS-mediated transformation. Negative regulator of amino acid starvation-induced autophagy. {ECO:0000250, ECO:0000269|PubMed:15031288, ECO:0000269|PubMed:22354037}. |
| Q5VT25 | CDC42BPA | S674 | ochoa | Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha) | Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration (PubMed:15723050, PubMed:9092543, PubMed:9418861). Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates: PPP1R12A, LIMK1 and LIMK2 (PubMed:11340065, PubMed:11399775). May play a role in TFRC-mediated iron uptake (PubMed:20188707). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). Triggers the formation of an extrusion apical actin ring required for epithelial extrusion of apoptotic cells (PubMed:29162624). {ECO:0000250|UniProtKB:Q3UU96, ECO:0000269|PubMed:11340065, ECO:0000269|PubMed:11399775, ECO:0000269|PubMed:15723050, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:20188707, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:29162624, ECO:0000269|PubMed:9092543, ECO:0000269|PubMed:9418861}. |
| Q5VWN6 | TASOR2 | S2037 | ochoa | Protein TASOR 2 | None |
| Q63HK5 | TSHZ3 | S515 | ochoa | Teashirt homolog 3 (Zinc finger protein 537) | Transcriptional regulator involved in developmental processes. Functions in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s) (PubMed:19343227). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter (By similarity). Involved in the modulation of glutamatergic synaptic transmission and long-term synaptic potentiation (By similarity). {ECO:0000250|UniProtKB:Q8CGV9, ECO:0000269|PubMed:19343227}. |
| Q658P3 | STEAP3 | S20 | ochoa | Metalloreductase STEAP3 (EC 1.16.1.-) (Dudulin-2) (Six-transmembrane epithelial antigen of prostate 3) (Tumor suppressor-activated pathway protein 6) (hTSAP6) (pHyde) (hpHyde) | Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane (PubMed:26205815). Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (By similarity). Can also reduce Cu(2+) to Cu(1+) (By similarity). Mediates efficient transferrin-dependent iron uptake in erythroid cells (By similarity). May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression (By similarity). Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP (PubMed:15319436, PubMed:16651434). {ECO:0000250|UniProtKB:Q5RKL5, ECO:0000250|UniProtKB:Q687X5, ECO:0000250|UniProtKB:Q8CI59, ECO:0000269|PubMed:15319436, ECO:0000269|PubMed:16651434, ECO:0000269|PubMed:26205815}. |
| Q69YN4 | VIRMA | S1766 | ochoa | Protein virilizer homolog | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:24981863, PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs in the 3'-UTR near the stop codon: recruits the catalytic core components METTL3 and METTL14, thereby guiding m6A methylation at specific sites (PubMed:29507755). Required for mRNA polyadenylation via its role in selective m6A methylation: m6A methylation of mRNAs in the 3'-UTR near the stop codon correlating with alternative polyadenylation (APA) (PubMed:29507755). {ECO:0000269|PubMed:24981863, ECO:0000269|PubMed:29507755}. |
| Q6IBW4 | NCAPH2 | S127 | ochoa | Condensin-2 complex subunit H2 (Chromosome-associated protein H2) (hCAP-H2) (Kleisin-beta) (Non-SMC condensin II complex subunit H2) | Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of chromatin bridges at anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (By similarity). Seems to have lineage-specific role in T-cell development (PubMed:14532007). {ECO:0000250|UniProtKB:Q8BSP2, ECO:0000269|PubMed:14532007}. |
| Q6IQ55 | TTBK2 | S422 | ochoa | Tau-tubulin kinase 2 (EC 2.7.11.1) | Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro (PubMed:23141541). Phosphorylates MPHOSPH9 which promotes its ubiquitination and proteasomal degradation, loss of MPHOSPH9 facilitates the removal of the CP110-CEP97 complex (a negative regulator of ciliogenesis) from the mother centrioles, promoting the initiation of ciliogenesis (PubMed:30375385). Required for recruitment of CPLANE2 and INTU to the mother centriole (By similarity). {ECO:0000250|UniProtKB:Q3UVR3, ECO:0000269|PubMed:21548880, ECO:0000269|PubMed:23141541, ECO:0000269|PubMed:30375385}. |
| Q6KC79 | NIPBL | S103 | ochoa | Nipped-B-like protein (Delangin) (SCC2 homolog) | Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}. |
| Q6NYC8 | PPP1R18 | S175 | ochoa | Phostensin (Protein phosphatase 1 F-actin cytoskeleton-targeting subunit) (Protein phosphatase 1 regulatory subunit 18) | [Isoform 1]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:24434620}.; FUNCTION: [Isoform 4]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:17374523}. |
| Q6PJT7 | ZC3H14 | S515 | ochoa | Zinc finger CCCH domain-containing protein 14 (Mammalian suppressor of tau pathology-2) (MSUT-2) (Renal carcinoma antigen NY-REN-37) | RNA-binding protein involved in the biogenesis of circular RNAs (circRNAs), which are produced by back-splicing circularization of pre-mRNAs (PubMed:39461343). Acts by binding to both exon-intron boundary and 3'-UTR of pre-mRNAs to promote circRNA biogenesis through dimerization and the association with the spliceosome (PubMed:39461343). Required for spermatogenesis via involvement in circRNA biogenesis (PubMed:39461343). Regulates the pre-mRNA processing of ATP5MC1; preventing its degradation (PubMed:27563065). Also binds the poly(A) tail of mRNAs; controlling poly(A) length in neuronal cells (PubMed:17630287, PubMed:24671764). {ECO:0000269|PubMed:17630287, ECO:0000269|PubMed:24671764, ECO:0000269|PubMed:27563065, ECO:0000269|PubMed:39461343}. |
| Q6WKZ4 | RAB11FIP1 | S313 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
| Q6ZRV2 | FAM83H | S945 | ochoa | Protein FAM83H | May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:18252228, ECO:0000269|PubMed:23902688}. |
| Q6ZS30 | NBEAL1 | S1339 | ochoa | Neurobeachin-like protein 1 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 16 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 17 protein) | None |
| Q71RC2 | LARP4 | S180 | ochoa | La-related protein 4 (La ribonucleoprotein domain family member 4) | RNA binding protein that binds to the poly-A tract of mRNA molecules (PubMed:21098120). Associates with the 40S ribosomal subunit and with polysomes (PubMed:21098120). Plays a role in the regulation of mRNA translation (PubMed:21098120). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987, PubMed:27615744). {ECO:0000269|PubMed:21098120, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:27615744}. |
| Q76L83 | ASXL2 | S51 | ochoa | Putative Polycomb group protein ASXL2 (Additional sex combs-like protein 2) | Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (PubMed:30664650, PubMed:36180891). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:30664650, PubMed:36180891). ASXL1, ASXL2 and ASXL3 function redundantly in the PR-DUB complex (By similarity) (PubMed:30664650). The ASXL proteins are essential for chromatin recruitment and transcriptional activation of associated genes (By similarity). ASXL1 and ASXL2 are important for BAP1 protein stability (PubMed:30664650). {ECO:0000250, ECO:0000250|UniProtKB:Q8BZ32, ECO:0000269|PubMed:21047783, ECO:0000269|PubMed:30664650, ECO:0000269|PubMed:36180891}. |
| Q7Z417 | NUFIP2 | S266 | ochoa | FMR1-interacting protein NUFIP2 (82 kDa FMRP-interacting protein) (82-FIP) (Cell proliferation-inducing gene 1 protein) (FMRP-interacting protein 2) (Nuclear FMR1-interacting protein 2) | Binds RNA. {ECO:0000269|PubMed:12837692}. |
| Q7Z739 | YTHDF3 | S385 | ochoa | YTH domain-containing family protein 3 (DF3) | Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates their stability (PubMed:28106072, PubMed:28106076, PubMed:28281539, PubMed:32492408). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing (PubMed:22575960, PubMed:24284625, PubMed:28106072, PubMed:28281539, PubMed:32492408). Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex or PAN3 (PubMed:32492408). The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) share m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation (PubMed:28106072, PubMed:28106076, PubMed:32492408). Acts as a negative regulator of type I interferon response by down-regulating interferon-stimulated genes (ISGs) expression: acts by binding to FOXO3 mRNAs (By similarity). Binds to FOXO3 mRNAs independently of METTL3-mediated m6A modification (By similarity). Can also act as a regulator of mRNA stability in cooperation with YTHDF2 by binding to m6A-containing mRNA and promoting their degradation (PubMed:28106072). Recognizes and binds m6A-containing circular RNAs (circRNAs); circRNAs are generated through back-splicing of pre-mRNAs, a non-canonical splicing process promoted by dsRNA structures across circularizing exons (PubMed:28281539). Promotes formation of phase-separated membraneless compartments, such as P-bodies or stress granules, by undergoing liquid-liquid phase separation upon binding to mRNAs containing multiple m6A-modified residues: polymethylated mRNAs act as a multivalent scaffold for the binding of YTHDF proteins, juxtaposing their disordered regions and thereby leading to phase separation (PubMed:31292544, PubMed:31388144, PubMed:32451507). The resulting mRNA-YTHDF complexes then partition into different endogenous phase-separated membraneless compartments, such as P-bodies, stress granules or neuronal RNA granules (PubMed:31292544). May also recognize and bind N1-methyladenosine (m1A)-containing mRNAs: inhibits trophoblast invasion by binding to m1A-methylated transcripts of IGF1R, promoting their degradation (PubMed:32194978). {ECO:0000250|UniProtKB:Q8BYK6, ECO:0000269|PubMed:22575960, ECO:0000269|PubMed:24284625, ECO:0000269|PubMed:28106072, ECO:0000269|PubMed:28106076, ECO:0000269|PubMed:28281539, ECO:0000269|PubMed:31292544, ECO:0000269|PubMed:31388144, ECO:0000269|PubMed:32194978, ECO:0000269|PubMed:32451507, ECO:0000269|PubMed:32492408}.; FUNCTION: Has some antiviral activity against HIV-1 virus: incorporated into HIV-1 particles in a nucleocapsid-dependent manner and reduces viral infectivity in the next cycle of infection (PubMed:32053707). May interfere with this early step of the viral life cycle by binding to N6-methyladenosine (m6A) modified sites on the HIV-1 RNA genome (PubMed:32053707). {ECO:0000269|PubMed:32053707}. |
| Q86UW9 | DTX2 | S360 | ochoa | Probable E3 ubiquitin-protein ligase DTX2 (EC 2.3.2.27) (Protein deltex-2) (Deltex2) (hDTX2) (RING finger protein 58) (RING-type E3 ubiquitin transferase DTX2) | Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. |
| Q8IY22 | CMIP | S377 | ochoa | C-Maf-inducing protein (c-Mip) (Truncated c-Maf-inducing protein) (Tc-Mip) | Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor. {ECO:0000269|PubMed:12939343, ECO:0000269|PubMed:15128042}. |
| Q8N0S6 | CENPL | S39 | ochoa | Centromere protein L (CENP-L) (Interphase centromere complex protein 33) | Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. {ECO:0000269|PubMed:16716197}. |
| Q8N163 | CCAR2 | S124 | ochoa | Cell cycle and apoptosis regulator protein 2 (Cell division cycle and apoptosis regulator protein 2) (DBIRD complex subunit KIAA1967) (Deleted in breast cancer gene 1 protein) (DBC-1) (DBC.1) (NET35) (p30 DBC) | Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions (PubMed:22446626). Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis (PubMed:18235501, PubMed:18235502, PubMed:23352644). Inhibits SUV39H1 methyltransferase activity (PubMed:19218236). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress (PubMed:23398316). Regulates the circadian expression of the core clock components NR1D1 and BMAL1 (PubMed:23398316). Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation (PubMed:23398316). Represses the ligand-dependent transcriptional activation function of ESR2 (PubMed:20074560). Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 (PubMed:24415752). Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization (PubMed:21030595). Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway (PubMed:24824780). Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (PubMed:25661920). Plays an important role in tumor suppression through p53/TP53 regulation; stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 (PubMed:25732823). Represses the transcriptional activator activity of BRCA1 (PubMed:20160719). Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro (PubMed:25361978). {ECO:0000269|PubMed:18235501, ECO:0000269|PubMed:18235502, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19218236, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:22446626, ECO:0000269|PubMed:23352644, ECO:0000269|PubMed:23398316, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25661920, ECO:0000269|PubMed:25732823}. |
| Q8N1G0 | ZNF687 | S1146 | ochoa | Zinc finger protein 687 | May be involved in transcriptional regulation. |
| Q8N3Z3 | GTPBP8 | S74 | ochoa | GTP-binding protein 8 | None |
| Q8N9U0 | TC2N | S168 | ochoa | Tandem C2 domains nuclear protein (Membrane targeting tandem C2 domain-containing protein 1) (Tandem C2 protein in nucleus) (Tac2-N) | None |
| Q8NAP3 | ZBTB38 | S130 | ochoa | Zinc finger and BTB domain-containing protein 38 | Transcriptional regulator with bimodal DNA-binding specificity. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to E-box elements (5'-CACGTG-3'). Can also bind specifically to a single methyl-CpG pair. Represses transcription in a methyl-CpG-dependent manner (PubMed:16354688). Plays an important role in regulating DNA replication and common fragile sites (CFS) stability in a RBBP6- and MCM10-dependent manner; represses expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). Acts as a transcriptional activator. May be involved in the differentiation and/or survival of late postmitotic neurons (By similarity). {ECO:0000250|UniProtKB:Q5EXX3, ECO:0000269|PubMed:16354688, ECO:0000269|PubMed:24726359}. |
| Q8NCN4 | RNF169 | S485 | ochoa | E3 ubiquitin-protein ligase RNF169 (EC 2.3.2.27) (RING finger protein 169) (RING-type E3 ubiquitin transferase RNF169) | Probable E3 ubiquitin-protein ligase that acts as a regulator of double-strand breaks (DSBs) repair following DNA damage. Functions in a non-canonical fashion to harness RNF168-mediated protein recruitment to DSB-containing chromatin, thereby contributing to regulation of DSB repair pathway utilization (PubMed:22492721, PubMed:30773093). Once recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168, competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby favouring homologous recombination repair (HRR) and single-strand annealing (SSA) instead of non-homologous end joining (NHEJ) mediated by TP53BP1 (PubMed:30104380, PubMed:30773093). E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair. {ECO:0000269|PubMed:22492721, ECO:0000269|PubMed:22733822, ECO:0000269|PubMed:22742833, ECO:0000269|PubMed:30104380, ECO:0000269|PubMed:30773093}. |
| Q8NF99 | ZNF397 | S242 | ochoa | Zinc finger protein 397 (Zinc finger and SCAN domain-containing protein 15) (Zinc finger protein 47) | Isoform 3 acts as a DNA-dependent transcriptional repressor. {ECO:0000269|PubMed:12801647}. |
| Q8NFP9 | NBEA | S2138 | ochoa | Neurobeachin (Lysosomal-trafficking regulator 2) (Protein BCL8B) | Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity). {ECO:0000250}. |
| Q8TAQ2 | SMARCC2 | S347 | ochoa | SWI/SNF complex subunit SMARCC2 (BRG1-associated factor 170) (BAF170) (SWI/SNF complex 170 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:11018012). Can stimulate the ATPase activity of the catalytic subunit of these complexes (PubMed:10078207). May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells (PubMed:12192000). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation (By similarity). {ECO:0000250|UniProtKB:Q6PDG5, ECO:0000269|PubMed:10078207, ECO:0000269|PubMed:11018012, ECO:0000269|PubMed:12192000, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q8TF30 | WHAMM | S606 | ochoa | WASP homolog-associated protein with actin, membranes and microtubules (WAS protein homology region 2 domain-containing protein 1) (WH2 domain-containing protein 1) | Acts as a nucleation-promoting factor (NPF) that stimulates Arp2/3-mediated actin polymerization both at the Golgi apparatus and along tubular membranes. Its activity in membrane tubulation requires F-actin and interaction with microtubules. Proposed to use coordinated actin-nucleating and microtubule-binding activities of distinct WHAMM molecules to drive membrane tubule elongation; when MT-bound can recruit and remodel membrane vesicles but is prevented to activate the Arp2/3 complex. Involved as a regulator of Golgi positioning and morphology. Participates in vesicle transport between the reticulum endoplasmic and the Golgi complex. Required for RhoD-dependent actin reorganization such as in cell adhesion and cell migration. {ECO:0000269|PubMed:18614018, ECO:0000269|PubMed:23027905, ECO:0000269|PubMed:23087206}. |
| Q8WUM0 | NUP133 | S1021 | ochoa | Nuclear pore complex protein Nup133 (133 kDa nucleoporin) (Nucleoporin Nup133) | Involved in poly(A)+ RNA transport. Involved in nephrogenesis (PubMed:30179222). {ECO:0000269|PubMed:11684705, ECO:0000269|PubMed:30179222}. |
| Q8WVB6 | CHTF18 | S64 | ochoa | Chromosome transmission fidelity protein 18 homolog (hCTF18) (CHL12) | Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. Interacts with and stimulates DNA polymerase POLH. During DNA repair synthesis, involved in loading DNA polymerase POLE at the sites of local damage (PubMed:20227374). {ECO:0000269|PubMed:12766176, ECO:0000269|PubMed:12930902, ECO:0000269|PubMed:17545166, ECO:0000269|PubMed:20227374}. |
| Q8WX92 | NELFB | S189 | ochoa | Negative elongation factor B (NELF-B) (Cofactor of BRCA1) | Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (PubMed:12612062). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (PubMed:10199401). May be able to induce chromatin unfolding (PubMed:11739404). Essential for early embryogenesis; plays an important role in maintaining the undifferentiated state of embryonic stem cells (ESCs) by preventing unscheduled expression of developmental genes (By similarity). Plays a key role in establishing the responsiveness of stem cells to developmental cues; facilitates plasticity and cell fate commitment in ESCs by establishing the appropriate expression level of signaling molecules (By similarity). Supports the transcription of genes involved in energy metabolism in cardiomyocytes; facilitates the association of transcription initiation factors with the promoters of the metabolism-related genes (By similarity). {ECO:0000250|UniProtKB:Q8C4Y3, ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:11739404, ECO:0000269|PubMed:12612062}.; FUNCTION: (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II (PubMed:23884411). In vitro, binds weakly to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1 (PubMed:23884411). {ECO:0000269|PubMed:23884411}. |
| Q8WXH0 | SYNE2 | S6775 | ochoa | Nesprin-2 (KASH domain-containing protein 2) (KASH2) (Nuclear envelope spectrin repeat protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE) (Synaptic nuclear envelope protein 2) (Syne-2) | Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (PubMed:34818527). Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. May be involved in nucleus-centrosome attachment. During interkinetic nuclear migration (INM) at G2 phase and nuclear migration in neural progenitors its LINC complex association with SUN1/2 and probable association with cytoplasmic dynein-dynactin motor complexes functions to pull the nucleus toward the centrosome; SYNE1 and SYNE2 may act redundantly. During INM at G1 phase mediates respective LINC complex association with kinesin to push the nucleus away from the centrosome. Involved in nuclear migration in retinal photoreceptor progenitors. Required for centrosome migration to the apical cell surface during early ciliogenesis. Facilitates the relaxation of mechanical stress imposed by compressive actin fibers at the rupture site through its nteraction with SYN2 (PubMed:34818527). {ECO:0000250|UniProtKB:Q6ZWQ0, ECO:0000269|PubMed:12118075, ECO:0000269|PubMed:18396275, ECO:0000269|PubMed:19596800, ECO:0000269|PubMed:20724637, ECO:0000269|PubMed:22945352, ECO:0000269|PubMed:34818527}. |
| Q92545 | TMEM131 | S1179 | ochoa | Transmembrane protein 131 (Protein RW1) | Collagen binding transmembrane protein involved in collagen secretion by recruiting the ER-to-Golgi transport complex TRAPPIII (PubMed:32095531). May play a role in the immune response to viral infection. {ECO:0000250, ECO:0000269|PubMed:32095531}. |
| Q92616 | GCN1 | S2276 | ochoa | Stalled ribosome sensor GCN1 (GCN1 eIF-2-alpha kinase activator homolog) (GCN1-like protein 1) (General control of amino-acid synthesis 1-like protein 1) (Translational activator GCN1) (HsGCN1) | Ribosome collision sensor that plays a key role in the RNF14-RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation factors on stalled ribosomes (PubMed:32610081, PubMed:36638793, PubMed:37651229, PubMed:37951215, PubMed:37951216). Directly binds to the ribosome and acts as a sentinel for colliding ribosomes: activated following ribosome stalling and promotes recruitment of RNF14, which directly ubiquitinates EEF1A1/eEF1A, leading to its degradation (PubMed:36638793, PubMed:37951215, PubMed:37951216). In addition to EEF1A1/eEF1A, the RNF14-RNF25 translation quality control pathway mediates degradation of ETF1/eRF1 and ubiquitination of ribosomal protein (PubMed:36638793, PubMed:37651229). GCN1 also acts as a positive activator of the integrated stress response (ISR) by mediating activation of EIF2AK4/GCN2 in response to amino acid starvation (By similarity). Interaction with EIF2AK4/GCN2 on translating ribosomes stimulates EIF2AK4/GCN2 kinase activity, leading to phosphorylation of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) (By similarity). EIF2S1/eIF-2-alpha phosphorylation converts EIF2S1/eIF-2-alpha into a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, and thus to a reduced overall utilization of amino acids, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion (By similarity). {ECO:0000250|UniProtKB:E9PVA8, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:36638793, ECO:0000269|PubMed:37651229, ECO:0000269|PubMed:37951215, ECO:0000269|PubMed:37951216}. |
| Q92664 | GTF3A | S347 | ochoa | Transcription factor IIIA (TFIIIA) | Involved in ribosomal large subunit biogenesis. Binds the approximately 50 base pairs internal control region (ICR) of 5S ribosomal RNA genes. It is required for their RNA polymerase III-dependent transcription and may also maintain the transcription of other genes (PubMed:24120868). Also binds the transcribed 5S RNA's (By similarity). {ECO:0000250|UniProtKB:P17842, ECO:0000269|PubMed:24120868}. |
| Q92835 | INPP5D | S27 | psp | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (EC 3.1.3.86) (Inositol polyphosphate-5-phosphatase D) (EC 3.1.3.56) (Inositol polyphosphate-5-phosphatase of 145 kDa) (SIP-145) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (SH2 domain-containing inositol 5'-phosphatase 1) (SH2 domain-containing inositol phosphatase 1) (SHIP-1) (p150Ship) (hp51CN) | Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:10764818, PubMed:8723348, PubMed:8769125). Able also to hydrolyzes the 5-phosphate of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P3) and inositol 1,3,4,5-tetrakisphosphate (PubMed:10764818, PubMed:8769125, PubMed:9108392). Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity (PubMed:16682172). Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. {ECO:0000269|PubMed:10764818, ECO:0000269|PubMed:12421919, ECO:0000269|PubMed:16682172, ECO:0000269|PubMed:8723348, ECO:0000269|PubMed:8769125, ECO:0000269|PubMed:9108392}. |
| Q92859 | NEO1 | S1178 | ochoa | Neogenin (Immunoglobulin superfamily DCC subclass member 2) | Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response. {ECO:0000269|PubMed:21149453}. |
| Q96C24 | SYTL4 | S488 | ochoa | Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin) | Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By similarity). {ECO:0000250}. |
| Q96C36 | PYCR2 | S294 | ochoa | Pyrroline-5-carboxylate reductase 2 (P5C reductase 2) (P5CR 2) (EC 1.5.1.2) | Oxidoreductase that catalyzes the last step in proline biosynthesis, which corresponds to the reduction of pyrroline-5-carboxylate to L-proline using NAD(P)H (PubMed:23024808, PubMed:2722838, PubMed:6894153). At physiologic concentrations, has higher specific activity in the presence of NADH (PubMed:23024808, PubMed:2722838, PubMed:6894153). Involved in cellular response to oxidative stress (PubMed:25865492). In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+) (PubMed:2722838, PubMed:6894153). {ECO:0000269|PubMed:23024808, ECO:0000269|PubMed:25865492, ECO:0000269|PubMed:2722838, ECO:0000269|PubMed:6894153}. |
| Q96HE9 | PRR11 | S307 | ochoa | Proline-rich protein 11 | Plays a critical role in cell cycle progression. {ECO:0000269|PubMed:23246489}. |
| Q96IT1 | ZNF496 | S221 | ochoa | Zinc finger protein 496 (Zinc finger protein with KRAB and SCAN domains 17) | DNA-binding transcription factor that can both act as an activator and a repressor. {ECO:0000250}. |
| Q96J02 | ITCH | S188 | ochoa | E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1) | Acts as an Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:11046148, PubMed:14602072, PubMed:15051726, PubMed:16387660, PubMed:17028573, PubMed:18718448, PubMed:18718449, PubMed:19116316, PubMed:19592251, PubMed:19881509, PubMed:20068034, PubMed:20392206, PubMed:20491914, PubMed:23146885, PubMed:24790097, PubMed:25631046). Catalyzes 'Lys-29'-, 'Lys-48'- and 'Lys-63'-linked ubiquitin conjugation (PubMed:17028573, PubMed:18718448, PubMed:19131965, PubMed:19881509). Involved in the control of inflammatory signaling pathways (PubMed:19131965). Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, TAX1BP1 and RNF11, that ensures the transient nature of inflammatory signaling pathways (PubMed:19131965). Promotes the association of the complex after TNF stimulation (PubMed:19131965). Once the complex is formed, TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains (PubMed:19131965). This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NFKB1 (PubMed:19131965). Ubiquitinates RIPK2 by 'Lys-63'-linked conjugation and influences NOD2-dependent signal transduction pathways (PubMed:19592251). Regulates the transcriptional activity of several transcription factors, and probably plays an important role in the regulation of immune response (PubMed:18718448, PubMed:20491914). Ubiquitinates NFE2 by 'Lys-63' linkages and is implicated in the control of the development of hematopoietic lineages (PubMed:18718448). Mediates JUN ubiquitination and degradation (By similarity). Mediates JUNB ubiquitination and degradation (PubMed:16387660). Critical regulator of type 2 helper T (Th2) cell cytokine production by inducing JUNB ubiquitination and degradation (By similarity). Involved in the negative regulation of MAVS-dependent cellular antiviral responses (PubMed:19881509). Ubiquitinates MAVS through 'Lys-48'-linked conjugation resulting in MAVS proteasomal degradation (PubMed:19881509). Following ligand stimulation, regulates sorting of Wnt receptor FZD4 to the degradative endocytic pathway probably by modulating PI42KA activity (PubMed:23146885). Ubiquitinates PI4K2A and negatively regulates its catalytic activity (PubMed:23146885). Ubiquitinates chemokine receptor CXCR4 and regulates sorting of CXCR4 to the degradative endocytic pathway following ligand stimulation by ubiquitinating endosomal sorting complex required for transport ESCRT-0 components HGS and STAM (PubMed:14602072, PubMed:23146885, PubMed:34927784). Targets DTX1 for lysosomal degradation and controls NOTCH1 degradation, in the absence of ligand, through 'Lys-29'-linked polyubiquitination (PubMed:17028573, PubMed:18628966, PubMed:23886940). Ubiquitinates SNX9 (PubMed:20491914). Ubiquitinates MAP3K7 through 'Lys-48'-linked conjugation (By similarity). Together with UBR5, involved in the regulation of apoptosis and reactive oxygen species levels through the ubiquitination and proteasomal degradation of TXNIP: catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP (PubMed:20068034, PubMed:29378950). ITCH synthesizes 'Lys-63'-linked chains, while UBR5 is branching multiple 'Lys-48'-linked chains of substrate initially modified (PubMed:29378950). Mediates the antiapoptotic activity of epidermal growth factor through the ubiquitination and proteasomal degradation of p15 BID (PubMed:20392206). Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Inhibits the replication of influenza A virus (IAV) via ubiquitination of IAV matrix protein 1 (M1) through 'Lys-48'-linked conjugation resulting in M1 proteasomal degradation (PubMed:30328013). Ubiquitinates NEDD9/HEF1, resulting in proteasomal degradation of NEDD9/HEF1 (PubMed:15051726). {ECO:0000250|UniProtKB:Q8C863, ECO:0000269|PubMed:14602072, ECO:0000269|PubMed:15051726, ECO:0000269|PubMed:16387660, ECO:0000269|PubMed:17028573, ECO:0000269|PubMed:18628966, ECO:0000269|PubMed:18718448, ECO:0000269|PubMed:18718449, ECO:0000269|PubMed:19116316, ECO:0000269|PubMed:19131965, ECO:0000269|PubMed:19592251, ECO:0000269|PubMed:19881509, ECO:0000269|PubMed:20068034, ECO:0000269|PubMed:20392206, ECO:0000269|PubMed:20491914, ECO:0000269|PubMed:23146885, ECO:0000269|PubMed:23886940, ECO:0000269|PubMed:24790097, ECO:0000269|PubMed:25631046, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:30328013}. |
| Q96JM3 | CHAMP1 | S736 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96KP1 | EXOC2 | S404 | ochoa | Exocyst complex component 2 (Exocyst complex component Sec5) | Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. {ECO:0000269|PubMed:12459492, ECO:0000269|PubMed:32639540}. |
| Q96LD4 | TRIM47 | S461 | ochoa | E3 ubiquitin-protein ligase TRIM47 (EC 2.3.2.27) (Gene overexpressed in astrocytoma protein) (RING finger protein 100) (Tripartite motif-containing protein 47) | E3 ubiquitin-protein ligase that mediates the ubiquitination and proteasomal degradation of CYLD. {ECO:0000269|PubMed:29291351}. |
| Q96MU7 | YTHDC1 | S77 | ochoa | YTH domain-containing protein 1 (Splicing factor YT521) (YT521-B) | Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:25242552, PubMed:26318451, PubMed:26876937, PubMed:28984244). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:25242552, PubMed:26318451). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May also regulate alternative splice site selection (PubMed:20167602). Also involved in nuclear export of m6A-containing mRNAs via interaction with SRSF3: interaction with SRSF3 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). Involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts, probably by binding m6A-containing MAT2A mRNAs (By similarity). Also recognizes and binds m6A on other RNA molecules (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: recognizes and binds m6A-containing Xist and promotes transcription repression activity of Xist (PubMed:27602518). Also recognizes and binds m6A-containing single-stranded DNA (PubMed:32663306). Involved in germline development: required for spermatogonial development in males and oocyte growth and maturation in females, probably via its role in alternative splicing (By similarity). {ECO:0000250|UniProtKB:E9Q5K9, ECO:0000269|PubMed:20167602, ECO:0000269|PubMed:25242552, ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:26876937, ECO:0000269|PubMed:27602518, ECO:0000269|PubMed:28984244, ECO:0000269|PubMed:32663306}. |
| Q96PC5 | MIA2 | S1156 | ochoa | Melanoma inhibitory activity protein 2 (MIA protein 2) (CTAGE family member 5 ER export factor) (Cutaneous T-cell lymphoma-associated antigen 5) (Meningioma-expressed antigen 6/11) | Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum (PubMed:21525241, PubMed:25202031, PubMed:27138255, PubMed:27170179). Plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum (PubMed:27138255). Thereby, may play a role in cholesterol and triglyceride homeostasis (By similarity). Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites (PubMed:21525241, PubMed:25202031, PubMed:27170179). {ECO:0000250|UniProtKB:Q91ZV0, ECO:0000269|PubMed:21525241, ECO:0000269|PubMed:25202031, ECO:0000269|PubMed:27138255, ECO:0000269|PubMed:27170179}. |
| Q96PY5 | FMNL2 | S183 | ochoa | Formin-like protein 2 (Formin homology 2 domain-containing protein 2) | Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics. {ECO:0000269|PubMed:21834987}. |
| Q96Q15 | SMG1 | S3570 | ochoa | Serine/threonine-protein kinase SMG1 (SMG-1) (hSMG-1) (EC 2.7.11.1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (Nonsense mediated mRNA decay-associated PI3K-related kinase SMG1) | Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ. {ECO:0000269|PubMed:11331269, ECO:0000269|PubMed:11544179, ECO:0000269|PubMed:15175154, ECO:0000269|PubMed:16452507}. |
| Q96QT6 | PHF12 | S769 | ochoa | PHD finger protein 12 (PHD factor 1) (Pf1) | Transcriptional repressor acting as key scaffolding subunit of SIN3 complexes which contributes to complex assembly by contacting each core subunit domain, stabilizes the complex and constitutes the substrate receptor by recruiting the H3 histone tail (PubMed:37137925). SIN3 complexes are composed of a SIN3 scaffold subunit, one catalytic core (HDAC1 or HDAC2) and 2 chromatin targeting modules (PubMed:11390640, PubMed:37137925). SIN3B complex represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2 (PubMed:37137925). SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription (PubMed:21041482). May also repress transcription in a SIN3A-independent manner through recruitment of functional TLE5 complexes to DNA (PubMed:11390640). May also play a role in ribosomal biogenesis (By similarity). {ECO:0000250|UniProtKB:Q5SPL2, ECO:0000269|PubMed:11390640, ECO:0000269|PubMed:21041482, ECO:0000269|PubMed:37137925}. |
| Q96ST3 | SIN3A | S421 | ochoa | Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a) | Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity). Required for cortical neuron differentiation and callosal axon elongation (By similarity). {ECO:0000250|UniProtKB:Q60520, ECO:0000269|PubMed:12150998}. |
| Q99550 | MPHOSPH9 | S984 | ochoa | M-phase phosphoprotein 9 | Negatively regulates cilia formation by recruiting the CP110-CEP97 complex (a negative regulator of ciliogenesis) at the distal end of the mother centriole in ciliary cells (PubMed:30375385). At the beginning of cilia formation, MPHOSPH9 undergoes TTBK2-mediated phosphorylation and degradation via the ubiquitin-proteasome system and removes itself and the CP110-CEP97 complex from the distal end of the mother centriole, which subsequently promotes cilia formation (PubMed:30375385). {ECO:0000269|PubMed:30375385}. |
| Q99717 | SMAD5 | S321 | ochoa | Mothers against decapentaplegic homolog 5 (MAD homolog 5) (Mothers against DPP homolog 5) (JV5-1) (SMAD family member 5) (SMAD 5) (Smad5) (hSmad5) | Transcriptional regulator that plays a role in various cellular processes including embryonic development, cell differentiation, angiogenesis and tissue homeostasis (PubMed:12064918, PubMed:16516194). Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD4 to form a heteromeric complex which translocates into the nucleus acting as transcription factor (PubMed:9442019). In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network (PubMed:33510867). Non-phosphorylated SMAD5 has a cytoplasmic role in energy metabolism regulation by promoting mitochondrial respiration and glycolysis in response to cytoplasmic pH changes (PubMed:28675158). Mechanistically, interacts with hexokinase 1/HK1 and thereby accelerates glycolysis (PubMed:28675158). {ECO:0000269|PubMed:12064918, ECO:0000269|PubMed:16516194, ECO:0000269|PubMed:28675158, ECO:0000269|PubMed:33510867, ECO:0000269|PubMed:9442019}. |
| Q9BPZ7 | MAPKAP1 | S270 | ochoa | Target of rapamycin complex 2 subunit MAPKAP1 (TORC2 subunit MAPKAP1) (Mitogen-activated protein kinase 2-associated protein 1) (Stress-activated map kinase-interacting protein 1) (SAPK-interacting protein 1) (mSIN1) | Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15467718, PubMed:16919458, PubMed:16962653, PubMed:17043309, PubMed:21806543, PubMed:28264193, PubMed:28968999, PubMed:30837283, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:16919458, PubMed:16962653, PubMed:21806543, PubMed:28264193, PubMed:28968999, PubMed:30837283, PubMed:35926713). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:16962653). Within the mTORC2 complex, MAPKAP1/SIN1 acts as a substrate adapter which recognizes and binds AGC protein kinase family members for phosphorylation by MTOR (PubMed:21806543, PubMed:28264193). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:28264193, PubMed:35926713). mTORC2 catalyzes the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657' (PubMed:30837283, PubMed:35926713). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:15467718). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (PubMed:15467718). MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation (PubMed:15988011). Inhibits HRAS and KRAS independently of mTORC2 complex (PubMed:17303383, PubMed:34380736, PubMed:35522713). Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription (PubMed:17054722). Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex (PubMed:23727834). {ECO:0000250|UniProtKB:Q8BKH7, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15988011, ECO:0000269|PubMed:16919458, ECO:0000269|PubMed:16962653, ECO:0000269|PubMed:17043309, ECO:0000269|PubMed:17054722, ECO:0000269|PubMed:17303383, ECO:0000269|PubMed:21806543, ECO:0000269|PubMed:23727834, ECO:0000269|PubMed:28264193, ECO:0000269|PubMed:28968999, ECO:0000269|PubMed:30837283, ECO:0000269|PubMed:34380736, ECO:0000269|PubMed:35522713, ECO:0000269|PubMed:35926713}.; FUNCTION: [Isoform 4]: In contrast to isoform 1, isoform 2 and isoform 6, isoform 4 is not a component of the a mTORC2 complex. {ECO:0000269|PubMed:26263164}. |
| Q9BQI7 | PSD2 | S191 | ochoa | PH and SEC7 domain-containing protein 2 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 C) (Exchange factor for ARF6 C) (Pleckstrin homology and SEC7 domain-containing protein 2) | None |
| Q9BSI4 | TINF2 | S295 | ochoa|psp | TERF1-interacting nuclear factor 2 (TRF1-interacting nuclear protein 2) | Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix. {ECO:0000269|PubMed:16166375, ECO:0000269|PubMed:16880378}. |
| Q9BUB5 | MKNK1 | S226 | ochoa | MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (MAPK signal-integrating kinase 1) (Mnk1) | May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. {ECO:0000269|PubMed:11463832, ECO:0000269|PubMed:15350534, ECO:0000269|PubMed:9155018, ECO:0000269|PubMed:9878069}. |
| Q9BXS6 | NUSAP1 | S135 | ochoa | Nucleolar and spindle-associated protein 1 (NuSAP) | Microtubule-associated protein with the capacity to bundle and stabilize microtubules (By similarity). May associate with chromosomes and promote the organization of mitotic spindle microtubules around them. {ECO:0000250, ECO:0000269|PubMed:12963707}. |
| Q9C0A6 | SETD5 | S1020 | ochoa | Histone-lysine N-methyltransferase SETD5 (EC 2.1.1.359) (EC 2.1.1.367) (SET domain-containing protein 5) | Chromatin regulator required for brain development: acts as a regulator of RNA elongation rate, thereby regulating neural stem cell (NSC) proliferation and synaptic transmission. May act by mediating trimethylation of 'Lys-36' of histone H3 (H3K36me3), which is essential to allow on-time RNA elongation dynamics. Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. The relevance of histone methyltransferase activity is however subject to discussion. {ECO:0000250|UniProtKB:Q5XJV7}. |
| Q9C0C2 | TNKS1BP1 | S1328 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9C0D5 | TANC1 | S1503 | ochoa | Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) | May be a scaffold component in the postsynaptic density. {ECO:0000250}. |
| Q9C0G0 | ZNF407 | S1262 | ochoa | Zinc finger protein 407 | May be involved in transcriptional regulation. |
| Q9H040 | SPRTN | S268 | ochoa | DNA-dependent metalloprotease SPRTN (EC 3.4.24.-) (DNA damage protein targeting VCP) (DVC1) (Protein with SprT-like domain at the N terminus) (Spartan) | DNA-dependent metalloendopeptidase that mediates the proteolytic cleavage of covalent DNA-protein cross-links (DPCs) during DNA synthesis, thereby playing a key role in maintaining genomic integrity (PubMed:27852435, PubMed:27871365, PubMed:27871366, PubMed:30893605, PubMed:32649882, PubMed:36608669). DPCs are highly toxic DNA lesions that interfere with essential chromatin transactions, such as replication and transcription, and which are induced by reactive agents, such as UV light or formaldehyde (PubMed:27852435, PubMed:27871365, PubMed:27871366, PubMed:32649882, PubMed:36608669). Associates with the DNA replication machinery and specifically removes DPCs during DNA synthesis (PubMed:27852435, PubMed:27871365, PubMed:27871366, PubMed:32649882). Catalyzes proteolytic cleavage of the HMCES DNA-protein cross-link following unfolding by the BRIP1/FANCJ helicase (PubMed:36608669). Acts as a pleiotropic protease for DNA-binding proteins cross-linked with DNA, such as TOP1, TOP2A, histones H3 and H4 (PubMed:27871366). Mediates degradation of DPCs that are not ubiquitinated, while it is not able to degrade ubiquitinated DPCs (By similarity). SPRTN activation requires polymerase collision with DPCs followed by helicase bypass of DPCs (By similarity). Involved in recruitment of VCP/p97 to sites of DNA damage (PubMed:22902628, PubMed:23042605, PubMed:23042607, PubMed:32152270). Also acts as an activator of CHEK1 during normal DNA replication by mediating proteolytic cleavage of CHEK1, thereby promoting CHEK1 removal from chromatin and subsequent activation (PubMed:31316063). Does not activate CHEK1 in response to DNA damage (PubMed:31316063). May also act as a 'reader' of ubiquitinated PCNA: recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA (PubMed:22681887, PubMed:22894931, PubMed:22902628, PubMed:22987070). Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis (PubMed:22681887). {ECO:0000250|UniProtKB:A0A1L8G2K9, ECO:0000269|PubMed:22681887, ECO:0000269|PubMed:22894931, ECO:0000269|PubMed:22902628, ECO:0000269|PubMed:22987070, ECO:0000269|PubMed:23042605, ECO:0000269|PubMed:23042607, ECO:0000269|PubMed:27852435, ECO:0000269|PubMed:27871365, ECO:0000269|PubMed:27871366, ECO:0000269|PubMed:30893605, ECO:0000269|PubMed:31316063, ECO:0000269|PubMed:32152270, ECO:0000269|PubMed:32649882, ECO:0000269|PubMed:36608669}. |
| Q9H0B6 | KLC2 | S175 | ochoa | Kinesin light chain 2 (KLC 2) | Kinesin is a microtubule-associated force-producing protein that plays a role in organelle transport. The light chain functions in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (Probable). Through binding with PLEKHM2 and ARL8B, recruits kinesin-1 to lysosomes and hence direct lysosomes movement toward microtubule plus ends (PubMed:22172677). {ECO:0000269|PubMed:22172677, ECO:0000305|PubMed:22172677}. |
| Q9H0H3 | KLHL25 | S285 | ochoa | Kelch-like protein 25 (Ectoderm-neural cortex protein 2) (ENC-2) | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex involved in various processes, such as translation homeostasis and lipid synthesis (PubMed:22578813, PubMed:27664236, PubMed:34491895). The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low (PubMed:22578813). The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E (PubMed:22578813). The BCR(KLHL25) complex also acts as a regulator of lipid synthesis by mediating ubiquitination and degradation of ACLY, thereby inhibiting lipid synthesis (PubMed:27664236, PubMed:34491895). BCR(KLHL25)-mediated degradation of ACLY promotes fatty acid oxidation and is required for differentiation of inducible regulatory T (iTreg) cells (PubMed:34491895). {ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:27664236, ECO:0000269|PubMed:34491895}. |
| Q9H4H8 | FAM83D | S298 | ochoa | Protein FAM83D (Spindle protein CHICA) | Through the degradation of FBXW7, may act indirectly on the expression and downstream signaling of MTOR, JUN and MYC (PubMed:24344117). May play also a role in cell proliferation through activation of the ERK1/ERK2 signaling cascade (PubMed:25646692). May also be important for proper chromosome congression and alignment during mitosis through its interaction with KIF22 (PubMed:18485706). {ECO:0000269|PubMed:18485706, ECO:0000269|PubMed:24344117, ECO:0000269|PubMed:25646692}. |
| Q9H6S1 | AZI2 | S318 | ochoa | 5-azacytidine-induced protein 2 (NF-kappa-B-activating kinase-associated protein 1) (Nak-associated protein 1) (Nap1) (TILP) | Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity (PubMed:14560022, PubMed:21931631). Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization (PubMed:14560022, PubMed:21931631). Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1 (PubMed:14560022, PubMed:21931631). Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B (PubMed:14560022, PubMed:21931631). Participates in IFNB promoter activation via TICAM1 (PubMed:15611223). {ECO:0000269|PubMed:14560022, ECO:0000269|PubMed:15611223, ECO:0000269|PubMed:21931631}. |
| Q9HAU0 | PLEKHA5 | S526 | ochoa | Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2) | None |
| Q9NQS3 | NECTIN3 | Y466 | ochoa | Nectin-3 (CDw113) (Nectin cell adhesion molecule 3) (Poliovirus receptor-related protein 3) (CD antigen CD113) | Cell adhesion molecule that promotes cell-cell adhesion through heterophilic trans-interactions with nectins-like or other nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions (PubMed:16216929). Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1 (PubMed:16216929). Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation (PubMed:16216929). Involved in axon guidance by promoting contacts between the commissural axons and the floor plate cells (By similarity). Also involved in the formation of cell-cell junctions, including adherens junctions and synapses (By similarity). Promotes formation of checkerboard-like cellular pattern of hair cells and supporting cells in the auditory epithelium via heterophilic interaction with NECTIN1: NECTIN1 is present in the membrane of hair cells and associates with NECTIN3 on supporting cells, thereby mediating heterotypic adhesion between these two cell types (By similarity). Plays a role in the morphology of the ciliary body (By similarity). {ECO:0000250|UniProtKB:Q9JLB9, ECO:0000269|PubMed:16216929}. |
| Q9NQS7 | INCENP | S798 | ochoa | Inner centromere protein | Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:12925766, PubMed:15316025, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428). {ECO:0000250|UniProtKB:P53352, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:21346195, ECO:0000269|PubMed:27332895}. |
| Q9NQT8 | KIF13B | S1293 | ochoa | Kinesin-like protein KIF13B (Kinesin-like protein GAKIN) | Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes. {ECO:0000269|PubMed:20194617}. |
| Q9NRA8 | EIF4ENIF1 | S78 | ochoa | Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) | EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}. |
| Q9NUL5 | SHFL | S246 | ochoa | Shiftless antiviral inhibitor of ribosomal frameshifting protein (SFL) (SHFL) (Interferon-regulated antiviral protein) (IRAV) (Repressor of yield of DENV protein) (RyDEN) | Inhibits programmed -1 ribosomal frameshifting (-1PRF) of a variety of mRNAs from viruses, such as HIV1, and cellular genes, such as PEG10. Interacts with the -1PRF signal of target mRNA and translating ribosomes and causes premature translation termination at the frameshifting site (PubMed:30682371). Regulates HIV1 GAG-POL expression by inhibiting -1PRF (PubMed:30682371). Exhibits antiviral activity against dengue virus (DENV) and can inhibit the replication of all DENV serotypes. May block the protein translation of DENV RNA via its association with cellular mRNA-binding proteins and viral RNA. Also interrupts Zika virus replication by promoting viral NS3 degradation via a lysosome-dependent pathway (PubMed:32150556). Can also limit the replication of hepatitis C virus (HCV) by restricting formation of viral replication organelle, West Nile virus (WNV), Chikungunya virus (CHIKV), herpes simplex virus type 1 (HHV-1), herpes virus type 8 (HHV-8) and human adenovirus (PubMed:26735137, PubMed:27974568, PubMed:30944177, PubMed:32294532). Binds nucleic acids with a higher affinity for ssRNA and ssDNA than for dsDNA (PubMed:27974568). {ECO:0000269|PubMed:26735137, ECO:0000269|PubMed:27974568, ECO:0000269|PubMed:30682371, ECO:0000269|PubMed:30944177, ECO:0000269|PubMed:32150556, ECO:0000269|PubMed:32294532}.; FUNCTION: Isoform 4 does not inhibit programmed ribosomal frameshifting (-1PRF). Does not bind to ribosomes. {ECO:0000269|PubMed:30682371}. |
| Q9NWZ5 | UCKL1 | S56 | ochoa | Uridine-cytidine kinase-like 1 (EC 2.7.1.48) | May contribute to UTP accumulation needed for blast transformation and proliferation. {ECO:0000269|PubMed:12199906}. |
| Q9NY74 | ETAA1 | S464 | ochoa | Ewing's tumor-associated antigen 1 (Ewing's tumor-associated antigen 16) | Replication stress response protein that accumulates at DNA damage sites and promotes replication fork progression and integrity (PubMed:27601467, PubMed:27723717, PubMed:27723720). Recruited to stalled replication forks via interaction with the RPA complex and directly stimulates ATR kinase activity independently of TOPBP1 (PubMed:27723717, PubMed:27723720, PubMed:30139873). Probably only regulates a subset of ATR targets (PubMed:27723717, PubMed:27723720). {ECO:0000269|PubMed:27601467, ECO:0000269|PubMed:27723717, ECO:0000269|PubMed:27723720, ECO:0000269|PubMed:30139873}. |
| Q9NZ56 | FMN2 | S747 | ochoa | Formin-2 | Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization (PubMed:21730168, PubMed:22330775). Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2 (PubMed:21730168, PubMed:22330775). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis (By similarity). Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress-induced cell cycle arrest (PubMed:23375502). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). Protects cells against apoptosis by protecting CDKN1A against degradation (PubMed:23375502). {ECO:0000250|UniProtKB:Q9JL04, ECO:0000269|PubMed:21730168, ECO:0000269|PubMed:22330775, ECO:0000269|PubMed:23375502, ECO:0000269|PubMed:26287480}. |
| Q9P246 | STIM2 | S640 | ochoa | Stromal interaction molecule 2 | Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx. {ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16860747, ECO:0000269|PubMed:17905723, ECO:0000269|PubMed:18160041, ECO:0000269|PubMed:21217057, ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:23359669}. |
| Q9P270 | SLAIN2 | S147 | ochoa | SLAIN motif-containing protein 2 | Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase. {ECO:0000269|PubMed:21646404}. |
| Q9P275 | USP36 | S429 | ochoa | Ubiquitin carboxyl-terminal hydrolase 36 (EC 2.3.2.-) (EC 3.4.19.12) (Deubiquitinating enzyme 36) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36) | Deubiquitinase essential for the regulation of nucleolar structure and function (PubMed:19208757, PubMed:22902402, PubMed:29273634). Required for cell and organism viability (PubMed:19208757, PubMed:22902402, PubMed:29273634). Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability (PubMed:19208757, PubMed:22902402, PubMed:29273634, PubMed:36912080). Functions as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (PubMed:29274341). Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex (PubMed:25775507). In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm (PubMed:25775507). Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions (PubMed:27445338). Deubiquitinates SOD2, regulates SOD2 protein stability (PubMed:21268071). Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins (PubMed:22622177). Promotes CEP63 stabilization through 'Lys-48'-linked deubiquitination leading to increased stability (PubMed:35989368). Acts as a SUMO ligase to promote EXOSC10 sumoylation critical for the nucleolar RNA exosome function in rRNA processing (PubMed:36912080). Binds to pre-rRNAs (PubMed:36912080). {ECO:0000269|PubMed:19208757, ECO:0000269|PubMed:21268071, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:22902402, ECO:0000269|PubMed:25775507, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:29273634, ECO:0000269|PubMed:29274341, ECO:0000269|PubMed:35989368, ECO:0000269|PubMed:36912080}. |
| Q9P2P5 | HECW2 | S407 | ochoa | E3 ubiquitin-protein ligase HECW2 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 2) (HECT-type E3 ubiquitin transferase HECW2) (NEDD4-like E3 ubiquitin-protein ligase 2) | E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73 (PubMed:12890487). Involved in the regulation of mitotic metaphase/anaphase transition (PubMed:24163370). {ECO:0000269|PubMed:12890487, ECO:0000269|PubMed:24163370}. |
| Q9P2Q2 | FRMD4A | S727 | ochoa | FERM domain-containing protein 4A | Scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex (By similarity). Plays a redundant role with FRMD4B in epithelial polarization (By similarity). May regulate MAPT secretion by activating ARF6-signaling (PubMed:27044754). {ECO:0000250|UniProtKB:Q8BIE6, ECO:0000269|PubMed:27044754}. |
| Q9UHL9 | GTF2IRD1 | S471 | ochoa | General transcription factor II-I repeat domain-containing protein 1 (GTF2I repeat domain-containing protein 1) (General transcription factor III) (MusTRD1/BEN) (Muscle TFII-I repeat domain-containing protein 1) (Slow-muscle-fiber enhancer-binding protein) (USE B1-binding protein) (Williams-Beuren syndrome chromosomal region 11 protein) (Williams-Beuren syndrome chromosomal region 12 protein) | May be a transcription regulator involved in cell-cycle progression and skeletal muscle differentiation. May repress GTF2I transcriptional functions, by preventing its nuclear residency, or by inhibiting its transcriptional activation. May contribute to slow-twitch fiber type specificity during myogenesis and in regenerating muscles. Binds troponin I slow-muscle fiber enhancer (USE B1). Binds specifically and with high affinity to the EFG sequences derived from the early enhancer of HOXC8 (By similarity). {ECO:0000250, ECO:0000269|PubMed:11438732}. |
| Q9UHV7 | MED13 | S848 | ochoa | Mediator of RNA polymerase II transcription subunit 13 (Activator-recruited cofactor 250 kDa component) (ARC250) (Mediator complex subunit 13) (Thyroid hormone receptor-associated protein 1) (Thyroid hormone receptor-associated protein complex 240 kDa component) (Trap240) (Vitamin D3 receptor-interacting protein complex component DRIP250) (DRIP250) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:16595664}. |
| Q9UIU6 | SIX4 | S249 | ochoa | Homeobox protein SIX4 (Sine oculis homeobox homolog 4) | Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a DNA sequence on these target genes and is involved in processes like cell differentiation, cell migration and cell survival. Transactivates gene expression by binding a 5'-[CAT]A[CT][CT][CTG]GA[GAT]-3' motif present in the Trex site and a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 site of the muscle-specific genes enhancer. Acts cooperatively with EYA proteins to transactivate their target genes through interaction and nuclear translocation of EYA protein. Acts synergistically with SIX1 to regulate target genes involved in formation of various organs, including muscle, kidney, gonad, ganglia, olfactory epithelium and cranial skeleton. Plays a role in several important steps of muscle development. Controls the genesis of hypaxial myogenic progenitors in the dermomyotome by transactivating PAX3 and the delamination and migration of the hypaxial precursors from the ventral lip to the limb buds through the transactivation of PAX3, MET and LBX1. Controls myoblast determination by transactivating MYF5, MYOD1 and MYF6. Controls somitic differentiation in myocyte through MYOG transactivation. Plays a role in synaptogenesis and sarcomere organization by participating in myofiber specialization during embryogenesis by activating fast muscle program in the primary myotome resulting in an up-regulation of fast muscle genes, including ATP2A1, MYL1 and TNNT3. Simultaneously, is also able to activate inhibitors of slow muscle genes, such as SOX6, HRASLS, and HDAC4, thereby restricting the activation of the slow muscle genes. During muscle regeneration, negatively regulates differentiation of muscle satellite cells through down-regulation of MYOG expression. During kidney development regulates the early stages of metanephros development and ureteric bud formation through regulation of GDNF, SALL1, PAX8 and PAX2 expression. Plays a role in gonad development by regulating both testis determination and size determination. In gonadal sex determination, transactivates ZFPM2 by binding a MEF3 consensus sequence, resulting in SRY up-regulation. In gonadal size determination, transactivates NR5A1 by binding a MEF3 consensus sequence resulting in gonadal precursor cell formation regulation. During olfactory development mediates the specification and patterning of olfactory placode through fibroblast growth factor and BMP4 signaling pathways and also regulates epithelial cell proliferation during placode formation. Promotes survival of sensory neurons during early trigeminal gangliogenesis. In the developing dorsal root ganglia, up-regulates SLC12A2 transcription. Regulates early thymus/parathyroid organogenesis through regulation of GCM2 and FOXN1 expression. Forms gustatory papillae during development of the tongue. Also plays a role during embryonic cranial skeleton morphogenesis. {ECO:0000250|UniProtKB:Q61321}. |
| Q9UIW0 | VAX2 | S42 | ochoa | Ventral anterior homeobox 2 | Transcription factor that may function in dorsoventral specification of the forebrain. Regulates the expression of Wnt signaling antagonists including the expression of a truncated TCF7L2 isoform that cannot bind CTNNB1 and acts therefore as a potent dominant-negative Wnt antagonist. Plays a crucial role in eye development and, in particular, in the specification of the ventral optic vesicle (By similarity). May be a regulator of axial polarization in the retina. {ECO:0000250}. |
| Q9UJY1 | HSPB8 | S24 | ochoa|psp | Heat shock protein beta-8 (HspB8) (Alpha-crystallin C chain) (E2-induced gene 1 protein) (Heat shock protein family B member 8) (Protein kinase H11) (Small stress protein-like protein HSP22) | Involved in the chaperone-assisted selective autophagy (CASA), a crucial process for protein quality control, particularly in mechanical strained cells and tissues such as muscle. Displays temperature-dependent chaperone activity. {ECO:0000250|UniProtKB:Q9JK92}. |
| Q9UPT6 | MAPK8IP3 | S1191 | ochoa | C-Jun-amino-terminal kinase-interacting protein 3 (JIP-3) (JNK-interacting protein 3) (JNK MAP kinase scaffold protein 3) (Mitogen-activated protein kinase 8-interacting protein 3) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:12189133). May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Promotes neuronal axon elongation in a kinesin- and JNK-dependent manner. Activates cofilin at axon tips via local activation of JNK, thereby regulating filopodial dynamics and enhancing axon elongation. Its binding to kinesin heavy chains (KHC), promotes kinesin-1 motility along microtubules and is essential for axon elongation and regeneration. Regulates cortical neuronal migration by mediating NTRK2/TRKB anterograde axonal transport during brain development (By similarity). Acts as an adapter that bridges the interaction between NTRK2/TRKB and KLC1 and drives NTRK2/TRKB axonal but not dendritic anterograde transport, which is essential for subsequent BDNF-triggered signaling and filopodia formation (PubMed:21775604). {ECO:0000250|UniProtKB:Q9ESN9, ECO:0000269|PubMed:12189133, ECO:0000269|PubMed:21775604}. |
| Q9Y2F5 | ICE1 | S516 | ochoa | Little elongation complex subunit 1 (Interactor of little elongator complex ELL subunit 1) | Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780). {ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23932780}. |
| Q9Y2G3 | ATP11B | S1145 | ochoa | Phospholipid-transporting ATPase IF (EC 7.6.2.1) (ATPase IR) (ATPase class VI type 11B) (P4-ATPase flippase complex alpha subunit ATP11B) | Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of intracellular membranes (PubMed:30018401). May contribute to the maintenance of membrane lipid asymmetry in endosome compartment (PubMed:30018401). {ECO:0000269|PubMed:30018401}. |
| Q9Y2T1 | AXIN2 | S70 | ochoa | Axin-2 (Axin-like protein) (Axil) (Axis inhibition protein 2) (Conductin) | Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B. {ECO:0000250|UniProtKB:O15169}. |
| Q9Y2X9 | ZNF281 | S160 | ochoa | Zinc finger protein 281 (GC-box-binding zinc finger protein 1) (Transcription factor ZBP-99) (Zinc finger DNA-binding protein 99) | Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs (By similarity). Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes. {ECO:0000250, ECO:0000269|PubMed:10448078, ECO:0000269|PubMed:12771217}. |
| Q9Y3M8 | STARD13 | S171 | ochoa | StAR-related lipid transfer protein 13 (46H23.2) (Deleted in liver cancer 2 protein) (DLC-2) (Rho GTPase-activating protein) (START domain-containing protein 13) (StARD13) | GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells. {ECO:0000269|PubMed:14697242, ECO:0000269|PubMed:16217026}. |
| Q9Y6I9 | TEX264 | S71 | ochoa | Testis-expressed protein 264 (Putative secreted protein Zsig11) | Major reticulophagy (also called ER-phagy) receptor that acts independently of other candidate reticulophagy receptors to remodel subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006537, PubMed:31006538). The ATG8-containing isolation membrane (IM) cradles a tubular segment of TEX264-positive ER near a three-way junction, allowing the formation of a synapse of 2 juxtaposed membranes with trans interaction between the TEX264 and ATG8 proteins (PubMed:31006537). Expansion of the IM would extend the capture of ER, possibly through a 'zipper-like' process involving continued trans TEX264-ATG8 interactions, until poorly understood mechanisms lead to the fission of relevant membranes and, ultimately, autophagosomal membrane closure (PubMed:31006537). Also involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis: acts by bridging VCP/p97 to covalent DNA-protein cross-links (DPCs) and initiating resolution of DPCs by SPRTN (PubMed:32152270). {ECO:0000269|PubMed:31006537, ECO:0000269|PubMed:31006538, ECO:0000269|PubMed:32152270}. |
| Q9Y6K5 | OAS3 | S792 | ochoa | 2'-5'-oligoadenylate synthase 3 ((2-5')oligo(A) synthase 3) (2-5A synthase 3) (EC 2.7.7.84) (p100 OAS) (p100OAS) | Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV). {ECO:0000269|PubMed:19056102, ECO:0000269|PubMed:19923450, ECO:0000269|PubMed:9880533}. |
| O00444 | PLK4 | S179 | Sugiyama | Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase 18) (Serine/threonine-protein kinase Sak) | Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (PubMed:22020124). Phosphorylates CEP131 at 'Ser-78' and PCM1 at 'Ser-372' which is essential for proper organization and integrity of centriolar satellites (PubMed:30804208). {ECO:0000269|PubMed:16244668, ECO:0000269|PubMed:16326102, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:18239451, ECO:0000269|PubMed:19164942, ECO:0000269|PubMed:21725316, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:27796307, ECO:0000269|PubMed:30804208}. |
| P05787 | KRT8 | S410 | Sugiyama | Keratin, type II cytoskeletal 8 (Cytokeratin-8) (CK-8) (Keratin-8) (K8) (Type-II keratin Kb8) | Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. {ECO:0000269|PubMed:16000376}. |
| P62241 | RPS8 | S66 | Sugiyama | Small ribosomal subunit protein eS8 (40S ribosomal protein S8) | Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| P49588 | AARS1 | Y690 | Sugiyama | Alanine--tRNA ligase, cytoplasmic (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS) (Protein lactyltransferase AARS1) (EC 6.-.-.-) (Renal carcinoma antigen NY-REN-42) | Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala) (PubMed:27622773, PubMed:27911835, PubMed:28493438, PubMed:33909043). Also edits incorrectly charged tRNA(Ala) via its editing domain (PubMed:27622773, PubMed:27911835, PubMed:28493438, PubMed:29273753). In presence of high levels of lactate, also acts as a protein lactyltransferase that mediates lactylation of lysine residues in target proteins, such as TEAD1, TP53/p53 and YAP1 (PubMed:38512451, PubMed:38653238). Protein lactylation takes place in a two-step reaction: lactate is first activated by ATP to form lactate-AMP and then transferred to lysine residues of target proteins (PubMed:38512451, PubMed:38653238, PubMed:39322678). Acts as an inhibitor of TP53/p53 activity by catalyzing lactylation of TP53/p53 (PubMed:38653238). Acts as a positive regulator of the Hippo pathway by mediating lactylation of TEAD1 and YAP1 (PubMed:38512451). {ECO:0000269|PubMed:27622773, ECO:0000269|PubMed:27911835, ECO:0000269|PubMed:28493438, ECO:0000269|PubMed:29273753, ECO:0000269|PubMed:33909043, ECO:0000269|PubMed:38512451, ECO:0000269|PubMed:38653238, ECO:0000269|PubMed:39322678}. |
| P07947 | YES1 | Y473 | Sugiyama | Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes) | Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGFR, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis. Catalyzes phosphorylation of organic cation transporter OCT2 which induces its transport activity (PubMed:26979622). {ECO:0000269|PubMed:11901164, ECO:0000269|PubMed:18479465, ECO:0000269|PubMed:19276087, ECO:0000269|PubMed:21566460, ECO:0000269|PubMed:21713032, ECO:0000269|PubMed:26979622}. |
| P12931 | SRC | Y466 | Sugiyama | Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src) | Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors (PubMed:34234773). Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates such as AFAP1. Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1 and to localize to actin filaments. Cytoskeletal reorganization is also controlled through the phosphorylation of cortactin (CTTN) (Probable). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN) (PubMed:21411625). In addition to phosphorylating focal adhesion proteins, SRC is also active at the sites of cell-cell contact adherens junctions and phosphorylates substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1), and plakoglobin (JUP). Another type of cell-cell junction, the gap junction, is also a target for SRC, which phosphorylates connexin-43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing and phosphorylates RNA-binding proteins such as KHDRBS1 (Probable). Phosphorylates PKP3 at 'Tyr-195' in response to reactive oxygen species, which may cause the release of PKP3 from desmosome cell junctions into the cytoplasm (PubMed:25501895). Also plays a role in PDGF-mediated tyrosine phosphorylation of both STAT1 and STAT3, leading to increased DNA binding activity of these transcription factors (By similarity). Involved in the RAS pathway through phosphorylation of RASA1 and RASGRF1 (PubMed:11389730). Plays a role in EGF-mediated calcium-activated chloride channel activation (PubMed:18586953). Required for epidermal growth factor receptor (EGFR) internalization through phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr-1477'. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization through phosphorylation and activation of GRK2, leading to beta-arrestin phosphorylation and internalization. Has a critical role in the stimulation of the CDK20/MAPK3 mitogen-activated protein kinase cascade by epidermal growth factor (Probable). Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus (PubMed:7853507). Plays an important role in osteoclastic bone resorption in conjunction with PTK2B/PYK2. Both the formation of a SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for this function. Recruited to activated integrins by PTK2B/PYK2, thereby phosphorylating CBL, which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:14585963, PubMed:8755529). Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase (PubMed:12615910). Phosphorylates DDR2 on tyrosine residues, thereby promoting its subsequent autophosphorylation (PubMed:16186108). Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731' (PubMed:20100835, PubMed:21309750). Enhances RIGI-elicited antiviral signaling (PubMed:19419966). Phosphorylates PDPK1 at 'Tyr-9', 'Tyr-373' and 'Tyr-376' (PubMed:14585963). Phosphorylates BCAR1 at 'Tyr-128' (PubMed:22710723). Phosphorylates CBLC at multiple tyrosine residues, phosphorylation at 'Tyr-341' activates CBLC E3 activity (PubMed:20525694). Phosphorylates synaptic vesicle protein synaptophysin (SYP) (By similarity). Involved in anchorage-independent cell growth (PubMed:19307596). Required for podosome formation (By similarity). Mediates IL6 signaling by activating YAP1-NOTCH pathway to induce inflammation-induced epithelial regeneration (PubMed:25731159). Phosphorylates OTUB1, promoting deubiquitination of RPTOR (PubMed:35927303). Phosphorylates caspase CASP8 at 'Tyr-380' which negatively regulates CASP8 processing and activation, down-regulating CASP8 proapoptotic function (PubMed:16619028). {ECO:0000250|UniProtKB:P05480, ECO:0000250|UniProtKB:Q9WUD9, ECO:0000269|PubMed:11389730, ECO:0000269|PubMed:12615910, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:16186108, ECO:0000269|PubMed:16619028, ECO:0000269|PubMed:18586953, ECO:0000269|PubMed:19307596, ECO:0000269|PubMed:19419966, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:20525694, ECO:0000269|PubMed:21309750, ECO:0000269|PubMed:21411625, ECO:0000269|PubMed:22710723, ECO:0000269|PubMed:25501895, ECO:0000269|PubMed:25731159, ECO:0000269|PubMed:34234773, ECO:0000269|PubMed:35927303, ECO:0000269|PubMed:7853507, ECO:0000269|PubMed:8755529, ECO:0000269|PubMed:8759729, ECO:0000305|PubMed:11964124, ECO:0000305|PubMed:8672527, ECO:0000305|PubMed:9442882}.; FUNCTION: [Isoform 1]: Non-receptor protein tyrosine kinase which phosphorylates synaptophysin with high affinity. {ECO:0000250|UniProtKB:Q9WUD9}.; FUNCTION: [Isoform 2]: Non-receptor protein tyrosine kinase which shows higher basal kinase activity than isoform 1, possibly due to weakened intramolecular interactions which enhance autophosphorylation of Tyr-419 and subsequent activation (By similarity). The SH3 domain shows reduced affinity with the linker sequence between the SH2 and kinase domains which may account for the increased basal activity (By similarity). Displays altered substrate specificity compared to isoform 1, showing weak affinity for synaptophysin and for peptide substrates containing class I or class II SH3 domain-binding motifs (By similarity). Plays a role in L1CAM-mediated neurite elongation, possibly by acting downstream of L1CAM to drive cytoskeletal rearrangements involved in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q9WUD9}.; FUNCTION: [Isoform 3]: Non-receptor protein tyrosine kinase which shows higher basal kinase activity than isoform 1, possibly due to weakened intramolecular interactions which enhance autophosphorylation of Tyr-419 and subsequent activation (By similarity). The SH3 domain shows reduced affinity with the linker sequence between the SH2 and kinase domains which may account for the increased basal activity (By similarity). Displays altered substrate specificity compared to isoform 1, showing weak affinity for synaptophysin and for peptide substrates containing class I or class II SH3 domain-binding motifs (By similarity). Plays a role in neurite elongation (By similarity). {ECO:0000250|UniProtKB:Q9WUD9}. |
| P09769 | FGR | Y459 | Sugiyama | Tyrosine-protein kinase Fgr (EC 2.7.10.2) (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog) (Proto-oncogene c-Fgr) (p55-Fgr) (p58-Fgr) (p58c-Fgr) | Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as a negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as a positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1. Together with CLNK, it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production (By similarity). {ECO:0000250|UniProtKB:P14234, ECO:0000269|PubMed:10739672, ECO:0000269|PubMed:17164290, ECO:0000269|PubMed:1737799, ECO:0000269|PubMed:7519620}. |
| P41279 | MAP3K8 | S358 | Sugiyama | Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (Cancer Osaka thyroid oncogene) (Proto-oncogene c-Cot) (Serine/threonine-protein kinase cot) (Tumor progression locus 2) (TPL-2) | Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the pro-inflammatory cytokine TNF-alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. In vitro, activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner, leading to up-regulation of IL8 and CCL4. Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types. In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insulin, leading to induction of lipolysis. Plays a role in the cell cycle. Isoform 1 shows some transforming activity, although it is much weaker than that of the activated oncogenic variant. {ECO:0000269|PubMed:11342626, ECO:0000269|PubMed:12667451, ECO:0000269|PubMed:15169888, ECO:0000269|PubMed:16371247, ECO:0000269|PubMed:1833717, ECO:0000269|PubMed:19001140, ECO:0000269|PubMed:19808894}. |
| P33992 | MCM5 | S398 | Sugiyama | DNA replication licensing factor MCM5 (EC 3.6.4.12) (CDC46 homolog) (P1-CDC46) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). {ECO:0000269|PubMed:16899510, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232}. |
| Q9NY33 | DPP3 | S242 | Sugiyama | Dipeptidyl peptidase 3 (EC 3.4.14.4) (Dipeptidyl aminopeptidase III) (Dipeptidyl arylamidase III) (Dipeptidyl peptidase III) (DPP III) (Enkephalinase B) | Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin (PubMed:1515063, PubMed:3233187). Also cleaves Arg-Arg-beta-naphthylamide (in vitro) (PubMed:11209758, PubMed:3233187, PubMed:9425109). {ECO:0000269|PubMed:11209758, ECO:0000269|PubMed:1515063, ECO:0000269|PubMed:3233187, ECO:0000269|PubMed:9425109}. |
| Q03112 | MECOM | S726 | SIGNOR | Histone-lysine N-methyltransferase MECOM (EC 2.1.1.367) (Ecotropic virus integration site 1 protein homolog) (EVI-1) (MDS1 and EVI1 complex locus protein) (Myelodysplasia syndrome 1 protein) (Myelodysplasia syndrome-associated protein 1) | [Isoform 1]: Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis. {ECO:0000269|PubMed:10856240, ECO:0000269|PubMed:11568182, ECO:0000269|PubMed:15897867, ECO:0000269|PubMed:16462766, ECO:0000269|PubMed:19767769, ECO:0000269|PubMed:9665135}.; FUNCTION: [Isoform 7]: Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation. Likely to be one of the primary histone methyltransferases along with PRDM16 that direct cytoplasmic H3K9me1 methylation. {ECO:0000250|UniProtKB:P14404}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 0.000001 | 5.936 |
| R-HSA-9022538 | Loss of MECP2 binding ability to 5mC-DNA | 0.000079 | 4.103 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 0.000085 | 4.070 |
| R-HSA-9022534 | Loss of MECP2 binding ability to 5hmC-DNA | 0.000497 | 3.304 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 0.000783 | 3.106 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.000452 | 3.345 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.000755 | 3.122 |
| R-HSA-1640170 | Cell Cycle | 0.000724 | 3.140 |
| R-HSA-9022702 | MECP2 regulates transcription of neuronal ligands | 0.001262 | 2.899 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.001340 | 2.873 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.001083 | 2.966 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.001484 | 2.828 |
| R-HSA-210990 | PECAM1 interactions | 0.001558 | 2.807 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.002272 | 2.644 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.002272 | 2.644 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.002272 | 2.644 |
| R-HSA-201451 | Signaling by BMP | 0.002075 | 2.683 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.002972 | 2.527 |
| R-HSA-1538133 | G0 and Early G1 | 0.003430 | 2.465 |
| R-HSA-196780 | Biotin transport and metabolism | 0.003674 | 2.435 |
| R-HSA-9022927 | MECP2 regulates transcription of genes involved in GABA signaling | 0.004288 | 2.368 |
| R-HSA-9707587 | Regulation of HMOX1 expression and activity | 0.004288 | 2.368 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.004847 | 2.315 |
| R-HSA-983189 | Kinesins | 0.005022 | 2.299 |
| R-HSA-9022535 | Loss of phosphorylation of MECP2 at T308 | 0.005775 | 2.238 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.006061 | 2.217 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.007465 | 2.127 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.007928 | 2.101 |
| R-HSA-9022707 | MECP2 regulates transcription factors | 0.011423 | 1.942 |
| R-HSA-3371599 | Defective HLCS causes multiple carboxylase deficiency | 0.011423 | 1.942 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 0.011423 | 1.942 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 0.011423 | 1.942 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.012974 | 1.887 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 0.015834 | 1.800 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.015097 | 1.821 |
| R-HSA-1221632 | Meiotic synapsis | 0.017186 | 1.765 |
| R-HSA-3323169 | Defects in biotin (Btn) metabolism | 0.016110 | 1.793 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.017170 | 1.765 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 0.018712 | 1.728 |
| R-HSA-68877 | Mitotic Prometaphase | 0.021691 | 1.664 |
| R-HSA-210747 | Regulation of gene expression in early pancreatic precursor cells | 0.021477 | 1.668 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 0.031417 | 1.503 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 0.031417 | 1.503 |
| R-HSA-9854907 | Regulation of MITF-M dependent genes involved in metabolism | 0.076709 | 1.115 |
| R-HSA-211163 | AKT-mediated inactivation of FOXO1A | 0.091333 | 1.039 |
| R-HSA-9854909 | Regulation of MITF-M dependent genes involved in invasion | 0.105726 | 0.976 |
| R-HSA-165160 | PDE3B signalling | 0.119891 | 0.921 |
| R-HSA-109703 | PKB-mediated events | 0.119891 | 0.921 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.030700 | 1.513 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.034065 | 1.468 |
| R-HSA-111367 | SLBP independent Processing of Histone Pre-mRNAs | 0.147555 | 0.831 |
| R-HSA-9632974 | NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis | 0.147555 | 0.831 |
| R-HSA-446107 | Type I hemidesmosome assembly | 0.161061 | 0.793 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.061157 | 1.214 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.069894 | 1.156 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 0.200312 | 0.698 |
| R-HSA-4839744 | Signaling by APC mutants | 0.200312 | 0.698 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.200312 | 0.698 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.200312 | 0.698 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.200312 | 0.698 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.212985 | 0.672 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.212985 | 0.672 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 0.088470 | 1.053 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 0.225458 | 0.647 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.225458 | 0.647 |
| R-HSA-3656253 | Defective EXT1 causes exostoses 1, TRPS2 and CHDS | 0.225458 | 0.647 |
| R-HSA-3656237 | Defective EXT2 causes exostoses 2 | 0.225458 | 0.647 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.225458 | 0.647 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.225458 | 0.647 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.225458 | 0.647 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.225458 | 0.647 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 0.249816 | 0.602 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.261707 | 0.582 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.261707 | 0.582 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 0.273410 | 0.563 |
| R-HSA-176412 | Phosphorylation of the APC/C | 0.273410 | 0.563 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.273410 | 0.563 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 0.273410 | 0.563 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 0.139952 | 0.854 |
| R-HSA-3560783 | Defective B4GALT7 causes EDS, progeroid type | 0.284929 | 0.545 |
| R-HSA-4420332 | Defective B3GALT6 causes EDSP2 and SEMDJL1 | 0.284929 | 0.545 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.050201 | 1.299 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 0.296266 | 0.528 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.296266 | 0.528 |
| R-HSA-3560801 | Defective B3GAT3 causes JDSSDHD | 0.296266 | 0.528 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 0.307424 | 0.512 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.065118 | 1.186 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.065118 | 1.186 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.105951 | 0.975 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.105951 | 0.975 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 0.318405 | 0.497 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.318405 | 0.497 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.318405 | 0.497 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.116019 | 0.935 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.329213 | 0.483 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.329213 | 0.483 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.329213 | 0.483 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.329213 | 0.483 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.339851 | 0.469 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.140809 | 0.851 |
| R-HSA-380287 | Centrosome maturation | 0.148195 | 0.829 |
| R-HSA-9857377 | Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autopha... | 0.360624 | 0.443 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 0.360624 | 0.443 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.390569 | 0.408 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.202970 | 0.693 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.409752 | 0.387 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.409752 | 0.387 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.409752 | 0.387 |
| R-HSA-171306 | Packaging Of Telomere Ends | 0.409752 | 0.387 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.289769 | 0.538 |
| R-HSA-191859 | snRNP Assembly | 0.289769 | 0.538 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.295637 | 0.529 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.419117 | 0.378 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.419117 | 0.378 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.428333 | 0.368 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.428333 | 0.368 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.437405 | 0.359 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.324846 | 0.488 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.446332 | 0.350 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.446332 | 0.350 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.370864 | 0.431 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.421077 | 0.376 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.023052 | 1.637 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.184643 | 0.734 |
| R-HSA-3928664 | Ephrin signaling | 0.307424 | 0.512 |
| R-HSA-73886 | Chromosome Maintenance | 0.365254 | 0.437 |
| R-HSA-180786 | Extension of Telomeres | 0.289769 | 0.538 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.075490 | 1.122 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.437405 | 0.359 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 0.065476 | 1.184 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.184643 | 0.734 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 0.350320 | 0.456 |
| R-HSA-9603381 | Activated NTRK3 signals through PI3K | 0.147555 | 0.831 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.088470 | 1.053 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.088470 | 1.053 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.307424 | 0.512 |
| R-HSA-171319 | Telomere Extension By Telomerase | 0.419117 | 0.378 |
| R-HSA-354192 | Integrin signaling | 0.129188 | 0.889 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.028633 | 1.543 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.053950 | 1.268 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.129974 | 0.886 |
| R-HSA-9603505 | NTRK3 as a dependence receptor | 0.046755 | 1.330 |
| R-HSA-191650 | Regulation of gap junction activity | 0.091333 | 1.039 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.044957 | 1.347 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.098246 | 1.008 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 0.237734 | 0.624 |
| R-HSA-174430 | Telomere C-strand synthesis initiation | 0.261707 | 0.582 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.073490 | 1.134 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.301498 | 0.521 |
| R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 0.083698 | 1.077 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 0.118632 | 0.926 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.033847 | 1.470 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.184643 | 0.734 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 0.329213 | 0.483 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.213499 | 0.671 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.213499 | 0.671 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.213499 | 0.671 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.415595 | 0.381 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.207689 | 0.683 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.093320 | 1.030 |
| R-HSA-77588 | SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs | 0.161061 | 0.793 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.261707 | 0.582 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.156438 | 0.806 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 0.296266 | 0.528 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.184643 | 0.734 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.190371 | 0.720 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.074406 | 1.128 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.437364 | 0.359 |
| R-HSA-420597 | Nectin/Necl trans heterodimerization | 0.105726 | 0.976 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.038881 | 1.410 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.066865 | 1.175 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 0.200312 | 0.698 |
| R-HSA-8874081 | MET activates PTK2 signaling | 0.400237 | 0.398 |
| R-HSA-4641265 | Repression of WNT target genes | 0.027477 | 1.561 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.178941 | 0.747 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.058941 | 1.230 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.213499 | 0.671 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.210396 | 0.677 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 0.093320 | 1.030 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.024401 | 1.613 |
| R-HSA-9032845 | Activated NTRK2 signals through CDK5 | 0.147555 | 0.831 |
| R-HSA-8866904 | Negative regulation of activity of TFAP2 (AP-2) family transcription factors | 0.161061 | 0.793 |
| R-HSA-176974 | Unwinding of DNA | 0.174353 | 0.759 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.212985 | 0.672 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.212985 | 0.672 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.284929 | 0.545 |
| R-HSA-162588 | Budding and maturation of HIV virion | 0.446332 | 0.350 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.365174 | 0.438 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.196123 | 0.707 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.307424 | 0.512 |
| R-HSA-9694614 | Attachment and Entry | 0.350320 | 0.456 |
| R-HSA-1500620 | Meiosis | 0.063139 | 1.200 |
| R-HSA-912631 | Regulation of signaling by CBL | 0.318405 | 0.497 |
| R-HSA-3295583 | TRP channels | 0.400237 | 0.398 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.223566 | 0.651 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.359464 | 0.444 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.300290 | 0.522 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.059279 | 1.227 |
| R-HSA-68882 | Mitotic Anaphase | 0.086275 | 1.064 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 0.061157 | 1.214 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 0.200312 | 0.698 |
| R-HSA-171007 | p38MAPK events | 0.261707 | 0.582 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.380746 | 0.419 |
| R-HSA-8873719 | RAB geranylgeranylation | 0.295637 | 0.529 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.419117 | 0.378 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.087736 | 1.057 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.342226 | 0.466 |
| R-HSA-9843745 | Adipogenesis | 0.416561 | 0.380 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.032733 | 1.485 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.437405 | 0.359 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.034065 | 1.468 |
| R-HSA-110320 | Translesion Synthesis by POLH | 0.318405 | 0.497 |
| R-HSA-68886 | M Phase | 0.029886 | 1.525 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.069894 | 1.156 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 0.261707 | 0.582 |
| R-HSA-373752 | Netrin-1 signaling | 0.201896 | 0.695 |
| R-HSA-480985 | Synthesis of dolichyl-phosphate-glucose | 0.133833 | 0.873 |
| R-HSA-418359 | Reduction of cytosolic Ca++ levels | 0.212985 | 0.672 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 0.225458 | 0.647 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.098246 | 1.008 |
| R-HSA-5694530 | Cargo concentration in the ER | 0.118632 | 0.926 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.129188 | 0.889 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.284929 | 0.545 |
| R-HSA-432142 | Platelet sensitization by LDL | 0.307424 | 0.512 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.151935 | 0.818 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.182859 | 0.738 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.260372 | 0.584 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.419117 | 0.378 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.437405 | 0.359 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.421077 | 0.376 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.079699 | 1.099 |
| R-HSA-456926 | Thrombin signalling through proteinase activated receptors (PARs) | 0.437405 | 0.359 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.309016 | 0.510 |
| R-HSA-200425 | Carnitine shuttle | 0.079009 | 1.102 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.370864 | 0.431 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.051534 | 1.288 |
| R-HSA-69236 | G1 Phase | 0.051534 | 1.288 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.029190 | 1.535 |
| R-HSA-5578775 | Ion homeostasis | 0.083918 | 1.076 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.410088 | 0.387 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.409752 | 0.387 |
| R-HSA-9909396 | Circadian clock | 0.090243 | 1.045 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.289769 | 0.538 |
| R-HSA-9669938 | Signaling by KIT in disease | 0.074406 | 1.128 |
| R-HSA-392518 | Signal amplification | 0.139952 | 0.854 |
| R-HSA-389397 | Orexin and neuropeptides FF and QRFP bind to their respective receptors | 0.119891 | 0.921 |
| R-HSA-418886 | Netrin mediated repulsion signals | 0.147555 | 0.831 |
| R-HSA-8948747 | Regulation of PTEN localization | 0.147555 | 0.831 |
| R-HSA-198693 | AKT phosphorylates targets in the nucleus | 0.174353 | 0.759 |
| R-HSA-425561 | Sodium/Calcium exchangers | 0.212985 | 0.672 |
| R-HSA-163615 | PKA activation | 0.307424 | 0.512 |
| R-HSA-429947 | Deadenylation of mRNA | 0.380746 | 0.419 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 0.428333 | 0.368 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.410088 | 0.387 |
| R-HSA-69481 | G2/M Checkpoints | 0.395315 | 0.403 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.036594 | 1.437 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.254491 | 0.594 |
| R-HSA-74160 | Gene expression (Transcription) | 0.074455 | 1.128 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.336448 | 0.473 |
| R-HSA-1266738 | Developmental Biology | 0.272820 | 0.564 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 0.174353 | 0.759 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.437405 | 0.359 |
| R-HSA-212436 | Generic Transcription Pathway | 0.043309 | 1.363 |
| R-HSA-69206 | G1/S Transition | 0.186779 | 0.729 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.025639 | 1.591 |
| R-HSA-69275 | G2/M Transition | 0.112434 | 0.949 |
| R-HSA-391160 | Signal regulatory protein family interactions | 0.034065 | 1.468 |
| R-HSA-428542 | Regulation of commissural axon pathfinding by SLIT and ROBO | 0.174353 | 0.759 |
| R-HSA-3000157 | Laminin interactions | 0.088470 | 1.053 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.249816 | 0.602 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.129188 | 0.889 |
| R-HSA-3296482 | Defects in vitamin and cofactor metabolism | 0.145405 | 0.837 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 0.329213 | 0.483 |
| R-HSA-167044 | Signalling to RAS | 0.339851 | 0.469 |
| R-HSA-69242 | S Phase | 0.051811 | 1.286 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.129965 | 0.886 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.116239 | 0.935 |
| R-HSA-983712 | Ion channel transport | 0.118165 | 0.928 |
| R-HSA-5617833 | Cilium Assembly | 0.243118 | 0.614 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.431962 | 0.365 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.051534 | 1.288 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 0.409752 | 0.387 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 0.037566 | 1.425 |
| R-HSA-189483 | Heme degradation | 0.026895 | 1.570 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 0.284929 | 0.545 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.050201 | 1.299 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.270117 | 0.568 |
| R-HSA-3371556 | Cellular response to heat stress | 0.365254 | 0.437 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 0.370765 | 0.431 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.400237 | 0.398 |
| R-HSA-77387 | Insulin receptor recycling | 0.419117 | 0.378 |
| R-HSA-2029481 | FCGR activation | 0.227735 | 0.643 |
| R-HSA-1474165 | Reproduction | 0.206176 | 0.686 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.032284 | 1.491 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.300290 | 0.522 |
| R-HSA-186712 | Regulation of beta-cell development | 0.093099 | 1.031 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.350320 | 0.456 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.283896 | 0.547 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.373873 | 0.427 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.318580 | 0.497 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.063452 | 1.198 |
| R-HSA-5576891 | Cardiac conduction | 0.416561 | 0.380 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.219324 | 0.659 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.353736 | 0.451 |
| R-HSA-9833110 | RSV-host interactions | 0.283014 | 0.548 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.101512 | 0.993 |
| R-HSA-9033500 | TYSND1 cleaves peroxisomal proteins | 0.119891 | 0.921 |
| R-HSA-9032500 | Activated NTRK2 signals through FYN | 0.161061 | 0.793 |
| R-HSA-8934903 | Receptor Mediated Mitophagy | 0.187436 | 0.727 |
| R-HSA-9635465 | Suppression of apoptosis | 0.200312 | 0.698 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.103244 | 0.986 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.108310 | 0.965 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 0.261707 | 0.582 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.139952 | 0.854 |
| R-HSA-201556 | Signaling by ALK | 0.167624 | 0.776 |
| R-HSA-111931 | PKA-mediated phosphorylation of CREB | 0.339851 | 0.469 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.360624 | 0.443 |
| R-HSA-9620244 | Long-term potentiation | 0.390569 | 0.408 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.352292 | 0.453 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.201896 | 0.695 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.240398 | 0.619 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.052833 | 1.277 |
| R-HSA-8983711 | OAS antiviral response | 0.225458 | 0.647 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.129188 | 0.889 |
| R-HSA-109582 | Hemostasis | 0.218242 | 0.661 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.067648 | 1.170 |
| R-HSA-199991 | Membrane Trafficking | 0.381404 | 0.419 |
| R-HSA-418360 | Platelet calcium homeostasis | 0.428333 | 0.368 |
| R-HSA-186763 | Downstream signal transduction | 0.446332 | 0.350 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.382184 | 0.418 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.382184 | 0.418 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.098246 | 1.008 |
| R-HSA-9707616 | Heme signaling | 0.102675 | 0.989 |
| R-HSA-189445 | Metabolism of porphyrins | 0.038881 | 1.410 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.144486 | 0.840 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.129188 | 0.889 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.224138 | 0.649 |
| R-HSA-9690406 | Transcriptional regulation of testis differentiation | 0.044957 | 1.347 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.079009 | 1.102 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.093320 | 1.030 |
| R-HSA-9683610 | Maturation of nucleoprotein | 0.237734 | 0.624 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.139952 | 0.854 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.216099 | 0.665 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.026895 | 1.570 |
| R-HSA-162582 | Signal Transduction | 0.440502 | 0.356 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.098246 | 1.008 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.190371 | 0.720 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.400237 | 0.398 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.365174 | 0.438 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.161061 | 0.793 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 0.350320 | 0.456 |
| R-HSA-9865881 | Complex III assembly | 0.380746 | 0.419 |
| R-HSA-73614 | Pyrimidine salvage | 0.419117 | 0.378 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.391040 | 0.408 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.272137 | 0.565 |
| R-HSA-1989781 | PPARA activates gene expression | 0.145279 | 0.838 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.092686 | 1.033 |
| R-HSA-180292 | GAB1 signalosome | 0.307424 | 0.512 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 0.318405 | 0.497 |
| R-HSA-2022377 | Metabolism of Angiotensinogen to Angiotensins | 0.350320 | 0.456 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.446332 | 0.350 |
| R-HSA-162710 | Synthesis of glycosylphosphatidylinositol (GPI) | 0.446332 | 0.350 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.229502 | 0.639 |
| R-HSA-5688426 | Deubiquitination | 0.277328 | 0.557 |
| R-HSA-8939211 | ESR-mediated signaling | 0.391171 | 0.408 |
| R-HSA-877300 | Interferon gamma signaling | 0.313383 | 0.504 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.103244 | 0.986 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 0.360624 | 0.443 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 0.390569 | 0.408 |
| R-HSA-177929 | Signaling by EGFR | 0.083918 | 1.076 |
| R-HSA-166520 | Signaling by NTRKs | 0.274367 | 0.562 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.232888 | 0.633 |
| R-HSA-417957 | P2Y receptors | 0.249816 | 0.602 |
| R-HSA-373753 | Nephrin family interactions | 0.329213 | 0.483 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.446332 | 0.350 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.179813 | 0.745 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.134545 | 0.871 |
| R-HSA-4086398 | Ca2+ pathway | 0.370864 | 0.431 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.150901 | 0.821 |
| R-HSA-9694631 | Maturation of nucleoprotein | 0.318405 | 0.497 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.360624 | 0.443 |
| R-HSA-525793 | Myogenesis | 0.400237 | 0.398 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.278018 | 0.556 |
| R-HSA-156590 | Glutathione conjugation | 0.295637 | 0.529 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.295563 | 0.529 |
| R-HSA-163685 | Integration of energy metabolism | 0.100228 | 0.999 |
| R-HSA-418038 | Nucleotide-like (purinergic) receptors | 0.307424 | 0.512 |
| R-HSA-3000170 | Syndecan interactions | 0.370765 | 0.431 |
| R-HSA-2262752 | Cellular responses to stress | 0.394424 | 0.404 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.225162 | 0.648 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.291643 | 0.535 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.356616 | 0.448 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.167624 | 0.776 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.307350 | 0.512 |
| R-HSA-917937 | Iron uptake and transport | 0.382184 | 0.418 |
| R-HSA-264876 | Insulin processing | 0.409752 | 0.387 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 0.139952 | 0.854 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.402417 | 0.395 |
| R-HSA-844456 | The NLRP3 inflammasome | 0.318405 | 0.497 |
| R-HSA-9830364 | Formation of the nephric duct | 0.088470 | 1.053 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.123883 | 0.907 |
| R-HSA-196791 | Vitamin D (calciferol) metabolism | 0.307424 | 0.512 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.196123 | 0.707 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 0.098246 | 1.008 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.207689 | 0.683 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.380746 | 0.419 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.380746 | 0.419 |
| R-HSA-191273 | Cholesterol biosynthesis | 0.398997 | 0.399 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.382184 | 0.418 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.248613 | 0.604 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.319025 | 0.496 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.410088 | 0.387 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.372964 | 0.428 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.435057 | 0.361 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.272137 | 0.565 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.409752 | 0.387 |
| R-HSA-622312 | Inflammasomes | 0.419117 | 0.378 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.365254 | 0.437 |
| R-HSA-75153 | Apoptotic execution phase | 0.213499 | 0.671 |
| R-HSA-8957322 | Metabolism of steroids | 0.187281 | 0.728 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.135651 | 0.868 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.324846 | 0.488 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.295637 | 0.529 |
| R-HSA-9830369 | Kidney development | 0.336448 | 0.473 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.387811 | 0.411 |
| R-HSA-1500931 | Cell-Cell communication | 0.448034 | 0.349 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.453399 | 0.344 |
| R-HSA-6807070 | PTEN Regulation | 0.454160 | 0.343 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.455119 | 0.342 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.455119 | 0.342 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.455119 | 0.342 |
| R-HSA-2024096 | HS-GAG degradation | 0.455119 | 0.342 |
| R-HSA-69190 | DNA strand elongation | 0.455119 | 0.342 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.455119 | 0.342 |
| R-HSA-9664407 | Parasite infection | 0.458278 | 0.339 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.458278 | 0.339 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.458278 | 0.339 |
| R-HSA-9663891 | Selective autophagy | 0.458686 | 0.338 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.463766 | 0.334 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.463766 | 0.334 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.463766 | 0.334 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.463766 | 0.334 |
| R-HSA-9930044 | Nuclear RNA decay | 0.463766 | 0.334 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.463766 | 0.334 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.463766 | 0.334 |
| R-HSA-9733709 | Cardiogenesis | 0.463766 | 0.334 |
| R-HSA-913531 | Interferon Signaling | 0.466127 | 0.331 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.470552 | 0.327 |
| R-HSA-390522 | Striated Muscle Contraction | 0.472277 | 0.326 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.472277 | 0.326 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.472277 | 0.326 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.472277 | 0.326 |
| R-HSA-8964539 | Glutamate and glutamine metabolism | 0.472277 | 0.326 |
| R-HSA-1971475 | Glycosaminoglycan-protein linkage region biosynthesis | 0.480654 | 0.318 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.480654 | 0.318 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.480654 | 0.318 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 0.480654 | 0.318 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.480654 | 0.318 |
| R-HSA-5673000 | RAF activation | 0.480654 | 0.318 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.480654 | 0.318 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.480654 | 0.318 |
| R-HSA-5205647 | Mitophagy | 0.480654 | 0.318 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.484670 | 0.315 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.485651 | 0.314 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.488898 | 0.311 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.488898 | 0.311 |
| R-HSA-917977 | Transferrin endocytosis and recycling | 0.488898 | 0.311 |
| R-HSA-187687 | Signalling to ERKs | 0.488898 | 0.311 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.488898 | 0.311 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.489774 | 0.310 |
| R-HSA-6798695 | Neutrophil degranulation | 0.495510 | 0.305 |
| R-HSA-2022928 | HS-GAG biosynthesis | 0.497011 | 0.304 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 0.497011 | 0.304 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.497011 | 0.304 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.497011 | 0.304 |
| R-HSA-111933 | Calmodulin induced events | 0.497011 | 0.304 |
| R-HSA-8853659 | RET signaling | 0.497011 | 0.304 |
| R-HSA-111997 | CaM pathway | 0.497011 | 0.304 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.497011 | 0.304 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.499887 | 0.301 |
| R-HSA-4641257 | Degradation of AXIN | 0.504997 | 0.297 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.504997 | 0.297 |
| R-HSA-110331 | Cleavage of the damaged purine | 0.504997 | 0.297 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.504997 | 0.297 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.504997 | 0.297 |
| R-HSA-390247 | Beta-oxidation of very long chain fatty acids | 0.504997 | 0.297 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.504997 | 0.297 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.505123 | 0.297 |
| R-HSA-397014 | Muscle contraction | 0.507466 | 0.295 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.509871 | 0.293 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.512856 | 0.290 |
| R-HSA-8875878 | MET promotes cell motility | 0.512856 | 0.290 |
| R-HSA-73927 | Depurination | 0.512856 | 0.290 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.512856 | 0.290 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.512856 | 0.290 |
| R-HSA-2046106 | alpha-linolenic acid (ALA) metabolism | 0.512856 | 0.290 |
| R-HSA-157579 | Telomere Maintenance | 0.514813 | 0.288 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.514813 | 0.288 |
| R-HSA-190236 | Signaling by FGFR | 0.519723 | 0.284 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.520590 | 0.284 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.520590 | 0.284 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.520590 | 0.284 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.520590 | 0.284 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.520590 | 0.284 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.520590 | 0.284 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.524600 | 0.280 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.528203 | 0.277 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.528203 | 0.277 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.528203 | 0.277 |
| R-HSA-9646399 | Aggrephagy | 0.528203 | 0.277 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.528203 | 0.277 |
| R-HSA-167169 | HIV Transcription Elongation | 0.528203 | 0.277 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.528203 | 0.277 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.528203 | 0.277 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.528203 | 0.277 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.528203 | 0.277 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.528203 | 0.277 |
| R-HSA-202433 | Generation of second messenger molecules | 0.528203 | 0.277 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.528203 | 0.277 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.528203 | 0.277 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.528203 | 0.277 |
| R-HSA-162587 | HIV Life Cycle | 0.529901 | 0.276 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.535694 | 0.271 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.535694 | 0.271 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.535694 | 0.271 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.535694 | 0.271 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.535694 | 0.271 |
| R-HSA-1280218 | Adaptive Immune System | 0.538467 | 0.269 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.539030 | 0.268 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.539030 | 0.268 |
| R-HSA-1483255 | PI Metabolism | 0.539030 | 0.268 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.543068 | 0.265 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.543068 | 0.265 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.543068 | 0.265 |
| R-HSA-189451 | Heme biosynthesis | 0.543068 | 0.265 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.543068 | 0.265 |
| R-HSA-9683701 | Translation of Structural Proteins | 0.543068 | 0.265 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.548481 | 0.261 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 0.550325 | 0.259 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 0.550325 | 0.259 |
| R-HSA-73928 | Depyrimidination | 0.550325 | 0.259 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.550325 | 0.259 |
| R-HSA-111996 | Ca-dependent events | 0.550325 | 0.259 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.557467 | 0.254 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 0.557467 | 0.254 |
| R-HSA-418346 | Platelet homeostasis | 0.562403 | 0.250 |
| R-HSA-5683826 | Surfactant metabolism | 0.564496 | 0.248 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.564496 | 0.248 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.566080 | 0.247 |
| R-HSA-69239 | Synthesis of DNA | 0.566975 | 0.246 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.566975 | 0.246 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.566975 | 0.246 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.571413 | 0.243 |
| R-HSA-774815 | Nucleosome assembly | 0.571413 | 0.243 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.571413 | 0.243 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.571413 | 0.243 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.571413 | 0.243 |
| R-HSA-3560782 | Diseases associated with glycosaminoglycan metabolism | 0.571413 | 0.243 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.571413 | 0.243 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.576016 | 0.240 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.578222 | 0.238 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.578222 | 0.238 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.578222 | 0.238 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.578222 | 0.238 |
| R-HSA-9675135 | Diseases of DNA repair | 0.578222 | 0.238 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.578222 | 0.238 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.578222 | 0.238 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.578222 | 0.238 |
| R-HSA-202403 | TCR signaling | 0.580484 | 0.236 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.582233 | 0.235 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.584922 | 0.233 |
| R-HSA-437239 | Recycling pathway of L1 | 0.584922 | 0.233 |
| R-HSA-2046104 | alpha-linolenic (omega3) and linoleic (omega6) acid metabolism | 0.584922 | 0.233 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.587821 | 0.231 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.589318 | 0.230 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.589318 | 0.230 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.589318 | 0.230 |
| R-HSA-9634597 | GPER1 signaling | 0.591517 | 0.228 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.591517 | 0.228 |
| R-HSA-425410 | Metal ion SLC transporters | 0.591517 | 0.228 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.592454 | 0.227 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.592454 | 0.227 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.592454 | 0.227 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.595963 | 0.225 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.598007 | 0.223 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.598007 | 0.223 |
| R-HSA-9766229 | Degradation of CDH1 | 0.598007 | 0.223 |
| R-HSA-73893 | DNA Damage Bypass | 0.598007 | 0.223 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.598013 | 0.223 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.598013 | 0.223 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.599453 | 0.222 |
| R-HSA-109704 | PI3K Cascade | 0.604394 | 0.219 |
| R-HSA-9748787 | Azathioprine ADME | 0.604394 | 0.219 |
| R-HSA-912446 | Meiotic recombination | 0.610681 | 0.214 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.610681 | 0.214 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.610797 | 0.214 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.610797 | 0.214 |
| R-HSA-2559583 | Cellular Senescence | 0.616603 | 0.210 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.616867 | 0.210 |
| R-HSA-72187 | mRNA 3'-end processing | 0.616867 | 0.210 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.616867 | 0.210 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.616867 | 0.210 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.616867 | 0.210 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.619146 | 0.208 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.622956 | 0.206 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.622956 | 0.206 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.622956 | 0.206 |
| R-HSA-5693538 | Homology Directed Repair | 0.623269 | 0.205 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.626654 | 0.203 |
| R-HSA-72649 | Translation initiation complex formation | 0.628949 | 0.201 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.628949 | 0.201 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 0.628949 | 0.201 |
| R-HSA-68875 | Mitotic Prophase | 0.631412 | 0.200 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.633307 | 0.198 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.634846 | 0.197 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.640650 | 0.193 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.640650 | 0.193 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.640650 | 0.193 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.643368 | 0.192 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.643368 | 0.192 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.643519 | 0.191 |
| R-HSA-112399 | IRS-mediated signalling | 0.646363 | 0.190 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.646363 | 0.190 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.646363 | 0.190 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.647285 | 0.189 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.651985 | 0.186 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.651985 | 0.186 |
| R-HSA-194138 | Signaling by VEGF | 0.655018 | 0.184 |
| R-HSA-1638091 | Heparan sulfate/heparin (HS-GAG) metabolism | 0.657517 | 0.182 |
| R-HSA-9033241 | Peroxisomal protein import | 0.657517 | 0.182 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.657517 | 0.182 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.657517 | 0.182 |
| R-HSA-114608 | Platelet degranulation | 0.662615 | 0.179 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.662963 | 0.179 |
| R-HSA-379724 | tRNA Aminoacylation | 0.662963 | 0.179 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.668322 | 0.175 |
| R-HSA-450294 | MAP kinase activation | 0.668322 | 0.175 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.668322 | 0.175 |
| R-HSA-8956321 | Nucleotide salvage | 0.668322 | 0.175 |
| R-HSA-112043 | PLC beta mediated events | 0.668322 | 0.175 |
| R-HSA-1442490 | Collagen degradation | 0.668322 | 0.175 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.673596 | 0.172 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.673596 | 0.172 |
| R-HSA-186797 | Signaling by PDGF | 0.673596 | 0.172 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.673596 | 0.172 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.673596 | 0.172 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.673758 | 0.171 |
| R-HSA-597592 | Post-translational protein modification | 0.673833 | 0.171 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.675606 | 0.170 |
| R-HSA-6799198 | Complex I biogenesis | 0.678786 | 0.168 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.678786 | 0.168 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.683895 | 0.165 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.683895 | 0.165 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.684602 | 0.165 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.688151 | 0.162 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.688922 | 0.162 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 0.693870 | 0.159 |
| R-HSA-5357801 | Programmed Cell Death | 0.697636 | 0.156 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.698739 | 0.156 |
| R-HSA-196807 | Nicotinate metabolism | 0.698739 | 0.156 |
| R-HSA-112040 | G-protein mediated events | 0.698739 | 0.156 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.702020 | 0.154 |
| R-HSA-9679506 | SARS-CoV Infections | 0.702678 | 0.153 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.702872 | 0.153 |
| R-HSA-167172 | Transcription of the HIV genome | 0.703531 | 0.153 |
| R-HSA-5218859 | Regulated Necrosis | 0.703531 | 0.153 |
| R-HSA-449147 | Signaling by Interleukins | 0.705980 | 0.151 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.708761 | 0.150 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.708937 | 0.149 |
| R-HSA-9658195 | Leishmania infection | 0.708937 | 0.149 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.712889 | 0.147 |
| R-HSA-448424 | Interleukin-17 signaling | 0.712889 | 0.147 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.712889 | 0.147 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 0.712889 | 0.147 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.717457 | 0.144 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.717457 | 0.144 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.717457 | 0.144 |
| R-HSA-975634 | Retinoid metabolism and transport | 0.717457 | 0.144 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.717457 | 0.144 |
| R-HSA-3000178 | ECM proteoglycans | 0.717457 | 0.144 |
| R-HSA-1632852 | Macroautophagy | 0.718633 | 0.143 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.721952 | 0.141 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.726377 | 0.139 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.726377 | 0.139 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.730731 | 0.136 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.730731 | 0.136 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.733006 | 0.135 |
| R-HSA-8852135 | Protein ubiquitination | 0.735016 | 0.134 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.735071 | 0.134 |
| R-HSA-5689603 | UCH proteinases | 0.739233 | 0.131 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.740581 | 0.130 |
| R-HSA-8951664 | Neddylation | 0.740697 | 0.130 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.743384 | 0.129 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.743384 | 0.129 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.747468 | 0.126 |
| R-HSA-216083 | Integrin cell surface interactions | 0.747468 | 0.126 |
| R-HSA-195721 | Signaling by WNT | 0.748188 | 0.126 |
| R-HSA-9675108 | Nervous system development | 0.748984 | 0.126 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.749532 | 0.125 |
| R-HSA-6806834 | Signaling by MET | 0.755444 | 0.122 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.755444 | 0.122 |
| R-HSA-9833482 | PKR-mediated signaling | 0.755444 | 0.122 |
| R-HSA-162906 | HIV Infection | 0.755544 | 0.122 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.757952 | 0.120 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.758217 | 0.120 |
| R-HSA-69306 | DNA Replication | 0.758217 | 0.120 |
| R-HSA-9609507 | Protein localization | 0.758217 | 0.120 |
| R-HSA-6806667 | Metabolism of fat-soluble vitamins | 0.759337 | 0.120 |
| R-HSA-977225 | Amyloid fiber formation | 0.759337 | 0.120 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.763862 | 0.117 |
| R-HSA-9612973 | Autophagy | 0.766642 | 0.115 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.770650 | 0.113 |
| R-HSA-390918 | Peroxisomal lipid metabolism | 0.770650 | 0.113 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.771996 | 0.112 |
| R-HSA-9711097 | Cellular response to starvation | 0.772116 | 0.112 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.774303 | 0.111 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.777478 | 0.109 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.777897 | 0.109 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.781434 | 0.107 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.781434 | 0.107 |
| R-HSA-109581 | Apoptosis | 0.782730 | 0.106 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.784915 | 0.105 |
| R-HSA-157118 | Signaling by NOTCH | 0.785370 | 0.105 |
| R-HSA-156902 | Peptide chain elongation | 0.788341 | 0.103 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.788341 | 0.103 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.791712 | 0.101 |
| R-HSA-73884 | Base Excision Repair | 0.795030 | 0.100 |
| R-HSA-202424 | Downstream TCR signaling | 0.795030 | 0.100 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.798296 | 0.098 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.801509 | 0.096 |
| R-HSA-4839726 | Chromatin organization | 0.804214 | 0.095 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.804672 | 0.094 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.804672 | 0.094 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.805042 | 0.094 |
| R-HSA-72306 | tRNA processing | 0.805042 | 0.094 |
| R-HSA-418555 | G alpha (s) signalling events | 0.807392 | 0.093 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.810847 | 0.091 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.810847 | 0.091 |
| R-HSA-1474290 | Collagen formation | 0.810847 | 0.091 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.813861 | 0.089 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.816828 | 0.088 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.816828 | 0.088 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.819747 | 0.086 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.822620 | 0.085 |
| R-HSA-611105 | Respiratory electron transport | 0.823146 | 0.085 |
| R-HSA-168255 | Influenza Infection | 0.825300 | 0.083 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.825447 | 0.083 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.825447 | 0.083 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.825447 | 0.083 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.825447 | 0.083 |
| R-HSA-422356 | Regulation of insulin secretion | 0.825447 | 0.083 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.828230 | 0.082 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.830760 | 0.081 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.830968 | 0.080 |
| R-HSA-70171 | Glycolysis | 0.830968 | 0.080 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.833663 | 0.079 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.833663 | 0.079 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.833663 | 0.079 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.836315 | 0.078 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.838736 | 0.076 |
| R-HSA-192823 | Viral mRNA Translation | 0.838925 | 0.076 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.841493 | 0.075 |
| R-HSA-111885 | Opioid Signalling | 0.841493 | 0.075 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.843652 | 0.074 |
| R-HSA-163125 | Post-translational modification: synthesis of GPI-anchored proteins | 0.844021 | 0.074 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.846508 | 0.072 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.846508 | 0.072 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.851365 | 0.070 |
| R-HSA-211000 | Gene Silencing by RNA | 0.851365 | 0.070 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.853736 | 0.069 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.853736 | 0.069 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.853736 | 0.069 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.853736 | 0.069 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.854900 | 0.068 |
| R-HSA-446728 | Cell junction organization | 0.855729 | 0.068 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.856069 | 0.067 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.857274 | 0.067 |
| R-HSA-73894 | DNA Repair | 0.857623 | 0.067 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.858365 | 0.066 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.858365 | 0.066 |
| R-HSA-392499 | Metabolism of proteins | 0.864286 | 0.063 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.865037 | 0.063 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.868752 | 0.061 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.869310 | 0.061 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.870396 | 0.060 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.871395 | 0.060 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.871944 | 0.060 |
| R-HSA-72172 | mRNA Splicing | 0.873627 | 0.059 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.875468 | 0.058 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.875468 | 0.058 |
| R-HSA-373760 | L1CAM interactions | 0.875468 | 0.058 |
| R-HSA-6805567 | Keratinization | 0.876784 | 0.057 |
| R-HSA-70326 | Glucose metabolism | 0.877455 | 0.057 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.877455 | 0.057 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.881336 | 0.055 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.881336 | 0.055 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.881407 | 0.055 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 0.885095 | 0.053 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.885825 | 0.053 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.886930 | 0.052 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.886930 | 0.052 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.890512 | 0.050 |
| R-HSA-422475 | Axon guidance | 0.890589 | 0.050 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.893981 | 0.049 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.893981 | 0.049 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.893981 | 0.049 |
| R-HSA-418990 | Adherens junctions interactions | 0.894250 | 0.049 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.898980 | 0.046 |
| R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 0.905283 | 0.043 |
| R-HSA-72312 | rRNA processing | 0.911717 | 0.040 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.916737 | 0.038 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 0.919404 | 0.036 |
| R-HSA-1474244 | Extracellular matrix organization | 0.919999 | 0.036 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.923183 | 0.035 |
| R-HSA-9824446 | Viral Infection Pathways | 0.927060 | 0.033 |
| R-HSA-2187338 | Visual phototransduction | 0.929133 | 0.032 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.930266 | 0.031 |
| R-HSA-421270 | Cell-cell junction organization | 0.931139 | 0.031 |
| R-HSA-8953854 | Metabolism of RNA | 0.932181 | 0.030 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.934623 | 0.029 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.934623 | 0.029 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.936698 | 0.028 |
| R-HSA-73887 | Death Receptor Signaling | 0.936698 | 0.028 |
| R-HSA-9610379 | HCMV Late Events | 0.939689 | 0.027 |
| R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 0.939689 | 0.027 |
| R-HSA-416476 | G alpha (q) signalling events | 0.942026 | 0.026 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.946132 | 0.024 |
| R-HSA-5619102 | SLC transporter disorders | 0.948679 | 0.023 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.952659 | 0.021 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.954164 | 0.020 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.954164 | 0.020 |
| R-HSA-168256 | Immune System | 0.955061 | 0.020 |
| R-HSA-3781865 | Diseases of glycosylation | 0.961628 | 0.017 |
| R-HSA-1483257 | Phospholipid metabolism | 0.961778 | 0.017 |
| R-HSA-375276 | Peptide ligand-binding receptors | 0.962849 | 0.016 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.965734 | 0.015 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 0.966824 | 0.015 |
| R-HSA-8978868 | Fatty acid metabolism | 0.967956 | 0.014 |
| R-HSA-5663205 | Infectious disease | 0.968262 | 0.014 |
| R-HSA-9609690 | HCMV Early Events | 0.968396 | 0.014 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.968396 | 0.014 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.973365 | 0.012 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.973938 | 0.011 |
| R-HSA-5668914 | Diseases of metabolism | 0.974968 | 0.011 |
| R-HSA-72766 | Translation | 0.975583 | 0.011 |
| R-HSA-9748784 | Drug ADME | 0.978220 | 0.010 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.979686 | 0.009 |
| R-HSA-382551 | Transport of small molecules | 0.980847 | 0.008 |
| R-HSA-15869 | Metabolism of nucleotides | 0.983731 | 0.007 |
| R-HSA-168249 | Innate Immune System | 0.984666 | 0.007 |
| R-HSA-556833 | Metabolism of lipids | 0.984929 | 0.007 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.986390 | 0.006 |
| R-HSA-9609646 | HCMV Infection | 0.987037 | 0.006 |
| R-HSA-388396 | GPCR downstream signalling | 0.988429 | 0.005 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.989942 | 0.004 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.990498 | 0.004 |
| R-HSA-418594 | G alpha (i) signalling events | 0.992106 | 0.003 |
| R-HSA-1643685 | Disease | 0.994842 | 0.002 |
| R-HSA-372790 | Signaling by GPCR | 0.995385 | 0.002 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.996048 | 0.002 |
| R-HSA-112316 | Neuronal System | 0.996729 | 0.001 |
| R-HSA-211859 | Biological oxidations | 0.998542 | 0.001 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.998840 | 0.001 |
| R-HSA-500792 | GPCR ligand binding | 0.999456 | 0.000 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.999649 | 0.000 |
| R-HSA-1430728 | Metabolism | 0.999999 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
KIS |
0.879 | 0.739 | 1 | 0.909 |
CDK18 |
0.876 | 0.811 | 1 | 0.943 |
CDK19 |
0.875 | 0.787 | 1 | 0.936 |
HIPK2 |
0.875 | 0.767 | 1 | 0.929 |
CDK17 |
0.875 | 0.826 | 1 | 0.949 |
CDK8 |
0.873 | 0.791 | 1 | 0.920 |
CDK7 |
0.871 | 0.783 | 1 | 0.928 |
P38G |
0.870 | 0.835 | 1 | 0.956 |
JNK2 |
0.869 | 0.838 | 1 | 0.948 |
DYRK2 |
0.866 | 0.744 | 1 | 0.880 |
CDK16 |
0.865 | 0.794 | 1 | 0.945 |
CDK3 |
0.864 | 0.718 | 1 | 0.951 |
CDK5 |
0.864 | 0.761 | 1 | 0.907 |
CDK1 |
0.863 | 0.772 | 1 | 0.932 |
P38D |
0.862 | 0.817 | 1 | 0.955 |
P38B |
0.862 | 0.802 | 1 | 0.920 |
CDK13 |
0.862 | 0.775 | 1 | 0.937 |
ERK1 |
0.861 | 0.790 | 1 | 0.934 |
CDK14 |
0.861 | 0.797 | 1 | 0.923 |
CDK12 |
0.859 | 0.779 | 1 | 0.944 |
DYRK4 |
0.859 | 0.748 | 1 | 0.943 |
HIPK4 |
0.858 | 0.507 | 1 | 0.717 |
JNK3 |
0.858 | 0.814 | 1 | 0.934 |
HIPK1 |
0.858 | 0.701 | 1 | 0.872 |
CLK3 |
0.857 | 0.507 | 1 | 0.696 |
DYRK1B |
0.857 | 0.732 | 1 | 0.911 |
P38A |
0.855 | 0.774 | 1 | 0.888 |
NLK |
0.854 | 0.714 | 1 | 0.744 |
CDK9 |
0.854 | 0.761 | 1 | 0.933 |
CDK10 |
0.853 | 0.739 | 1 | 0.932 |
DYRK1A |
0.853 | 0.625 | 1 | 0.863 |
ERK2 |
0.850 | 0.780 | 1 | 0.902 |
HIPK3 |
0.849 | 0.681 | 1 | 0.850 |
DYRK3 |
0.846 | 0.595 | 1 | 0.839 |
SRPK1 |
0.845 | 0.339 | -3 | 0.742 |
CDK4 |
0.845 | 0.765 | 1 | 0.945 |
CLK4 |
0.841 | 0.442 | -3 | 0.769 |
CLK1 |
0.841 | 0.453 | -3 | 0.742 |
CDK6 |
0.841 | 0.733 | 1 | 0.934 |
ERK5 |
0.841 | 0.383 | 1 | 0.664 |
CDK2 |
0.840 | 0.594 | 1 | 0.851 |
ICK |
0.840 | 0.398 | -3 | 0.829 |
SRPK2 |
0.839 | 0.286 | -3 | 0.678 |
CLK2 |
0.838 | 0.443 | -3 | 0.742 |
MTOR |
0.836 | 0.203 | 1 | 0.559 |
JNK1 |
0.835 | 0.723 | 1 | 0.942 |
CDKL5 |
0.834 | 0.191 | -3 | 0.792 |
MAK |
0.833 | 0.523 | -2 | 0.791 |
COT |
0.831 | -0.064 | 2 | 0.841 |
CDKL1 |
0.830 | 0.163 | -3 | 0.800 |
NDR2 |
0.828 | 0.041 | -3 | 0.832 |
CDC7 |
0.828 | -0.067 | 1 | 0.420 |
PIM3 |
0.824 | 0.011 | -3 | 0.821 |
MOS |
0.823 | -0.022 | 1 | 0.468 |
SRPK3 |
0.823 | 0.233 | -3 | 0.722 |
PRP4 |
0.823 | 0.451 | -3 | 0.753 |
AURC |
0.823 | 0.143 | -2 | 0.762 |
PRPK |
0.823 | -0.100 | -1 | 0.904 |
TBK1 |
0.823 | -0.134 | 1 | 0.362 |
MST4 |
0.822 | 0.024 | 2 | 0.843 |
NEK6 |
0.822 | -0.027 | -2 | 0.823 |
MOK |
0.822 | 0.478 | 1 | 0.776 |
NDR1 |
0.821 | 0.022 | -3 | 0.828 |
CAMK1B |
0.820 | 0.010 | -3 | 0.856 |
RSK2 |
0.820 | 0.058 | -3 | 0.772 |
GCN2 |
0.818 | -0.177 | 2 | 0.782 |
PDHK4 |
0.818 | -0.160 | 1 | 0.469 |
CAMLCK |
0.818 | 0.083 | -2 | 0.881 |
ATR |
0.817 | -0.045 | 1 | 0.434 |
RAF1 |
0.817 | -0.164 | 1 | 0.411 |
ULK2 |
0.817 | -0.160 | 2 | 0.783 |
SKMLCK |
0.817 | 0.040 | -2 | 0.885 |
TGFBR2 |
0.816 | -0.052 | -2 | 0.770 |
PRKD1 |
0.816 | -0.004 | -3 | 0.808 |
NUAK2 |
0.816 | 0.024 | -3 | 0.829 |
P90RSK |
0.816 | 0.041 | -3 | 0.774 |
PKN3 |
0.816 | -0.022 | -3 | 0.819 |
IKKE |
0.816 | -0.161 | 1 | 0.355 |
RSK3 |
0.816 | 0.039 | -3 | 0.755 |
WNK1 |
0.816 | -0.034 | -2 | 0.863 |
BMPR2 |
0.816 | -0.161 | -2 | 0.840 |
PDHK1 |
0.815 | -0.145 | 1 | 0.442 |
PKACG |
0.815 | 0.059 | -2 | 0.797 |
DAPK2 |
0.815 | 0.047 | -3 | 0.864 |
PKCD |
0.814 | 0.024 | 2 | 0.768 |
NIK |
0.814 | -0.026 | -3 | 0.873 |
PIM1 |
0.814 | 0.053 | -3 | 0.778 |
PAK6 |
0.814 | 0.107 | -2 | 0.798 |
PRKD2 |
0.813 | 0.022 | -3 | 0.767 |
NEK7 |
0.813 | -0.129 | -3 | 0.862 |
AMPKA1 |
0.813 | -0.025 | -3 | 0.843 |
DSTYK |
0.813 | -0.139 | 2 | 0.840 |
MARK4 |
0.812 | -0.036 | 4 | 0.833 |
P70S6KB |
0.812 | 0.042 | -3 | 0.801 |
LATS2 |
0.811 | -0.023 | -5 | 0.774 |
AURB |
0.811 | 0.112 | -2 | 0.761 |
IKKB |
0.811 | -0.198 | -2 | 0.696 |
WNK3 |
0.810 | -0.129 | 1 | 0.395 |
TSSK1 |
0.810 | -0.002 | -3 | 0.859 |
RIPK3 |
0.810 | -0.110 | 3 | 0.748 |
CAMK2G |
0.809 | -0.113 | 2 | 0.787 |
NIM1 |
0.809 | -0.034 | 3 | 0.779 |
PKN2 |
0.809 | -0.038 | -3 | 0.827 |
MNK2 |
0.809 | 0.053 | -2 | 0.850 |
PAK1 |
0.809 | 0.054 | -2 | 0.853 |
PAK3 |
0.808 | 0.034 | -2 | 0.843 |
PKACB |
0.808 | 0.116 | -2 | 0.767 |
ULK1 |
0.808 | -0.156 | -3 | 0.825 |
AMPKA2 |
0.808 | -0.017 | -3 | 0.815 |
LATS1 |
0.807 | 0.041 | -3 | 0.846 |
PKG2 |
0.807 | 0.088 | -2 | 0.758 |
CHAK2 |
0.807 | -0.082 | -1 | 0.881 |
IRE1 |
0.805 | -0.087 | 1 | 0.384 |
IKKA |
0.805 | -0.099 | -2 | 0.682 |
RSK4 |
0.804 | 0.062 | -3 | 0.745 |
BCKDK |
0.804 | -0.152 | -1 | 0.847 |
ERK7 |
0.804 | 0.223 | 2 | 0.480 |
NEK9 |
0.804 | -0.167 | 2 | 0.828 |
MASTL |
0.804 | -0.182 | -2 | 0.779 |
NUAK1 |
0.804 | -0.021 | -3 | 0.792 |
MELK |
0.804 | -0.036 | -3 | 0.806 |
MLK1 |
0.803 | -0.174 | 2 | 0.793 |
AKT2 |
0.803 | 0.085 | -3 | 0.691 |
PKCA |
0.803 | 0.008 | 2 | 0.709 |
AURA |
0.803 | 0.098 | -2 | 0.745 |
MSK2 |
0.803 | 0.021 | -3 | 0.738 |
IRE2 |
0.803 | -0.061 | 2 | 0.755 |
MLK2 |
0.802 | -0.131 | 2 | 0.799 |
SGK3 |
0.802 | 0.059 | -3 | 0.748 |
TSSK2 |
0.802 | -0.067 | -5 | 0.811 |
MNK1 |
0.802 | 0.047 | -2 | 0.852 |
MAPKAPK3 |
0.802 | -0.069 | -3 | 0.769 |
QSK |
0.802 | -0.014 | 4 | 0.817 |
GRK5 |
0.802 | -0.182 | -3 | 0.839 |
PAK2 |
0.801 | 0.032 | -2 | 0.838 |
HUNK |
0.801 | -0.171 | 2 | 0.789 |
PIM2 |
0.801 | 0.065 | -3 | 0.748 |
PRKD3 |
0.801 | 0.004 | -3 | 0.736 |
CAMK4 |
0.801 | -0.066 | -3 | 0.819 |
ALK4 |
0.801 | -0.048 | -2 | 0.784 |
GRK1 |
0.800 | -0.062 | -2 | 0.738 |
CAMK2D |
0.800 | -0.115 | -3 | 0.840 |
PRKX |
0.800 | 0.107 | -3 | 0.676 |
BMPR1B |
0.800 | -0.033 | 1 | 0.385 |
PHKG1 |
0.800 | -0.063 | -3 | 0.824 |
PKCZ |
0.799 | -0.025 | 2 | 0.757 |
PKCB |
0.799 | -0.020 | 2 | 0.715 |
TGFBR1 |
0.799 | -0.041 | -2 | 0.748 |
QIK |
0.799 | -0.076 | -3 | 0.836 |
VRK2 |
0.799 | 0.034 | 1 | 0.503 |
SIK |
0.799 | -0.022 | -3 | 0.768 |
PKCG |
0.798 | -0.021 | 2 | 0.709 |
RIPK1 |
0.798 | -0.180 | 1 | 0.390 |
MSK1 |
0.798 | 0.050 | -3 | 0.738 |
ATM |
0.798 | -0.086 | 1 | 0.384 |
ANKRD3 |
0.798 | -0.181 | 1 | 0.424 |
MPSK1 |
0.798 | 0.063 | 1 | 0.466 |
MLK3 |
0.797 | -0.081 | 2 | 0.717 |
GRK7 |
0.797 | -0.009 | 1 | 0.420 |
PINK1 |
0.797 | 0.138 | 1 | 0.584 |
MAPKAPK2 |
0.797 | -0.042 | -3 | 0.723 |
NEK2 |
0.797 | -0.107 | 2 | 0.796 |
PKR |
0.796 | -0.086 | 1 | 0.414 |
MYLK4 |
0.796 | 0.044 | -2 | 0.827 |
PAK5 |
0.796 | 0.079 | -2 | 0.757 |
DNAPK |
0.796 | -0.046 | 1 | 0.371 |
PKCH |
0.796 | -0.033 | 2 | 0.709 |
GRK6 |
0.794 | -0.158 | 1 | 0.402 |
AKT1 |
0.794 | 0.080 | -3 | 0.707 |
DLK |
0.794 | -0.257 | 1 | 0.419 |
MARK2 |
0.794 | -0.032 | 4 | 0.764 |
YSK4 |
0.793 | -0.169 | 1 | 0.387 |
PKACA |
0.793 | 0.093 | -2 | 0.727 |
MARK3 |
0.793 | -0.029 | 4 | 0.786 |
PLK1 |
0.793 | -0.133 | -2 | 0.779 |
FAM20C |
0.793 | -0.021 | 2 | 0.578 |
BRSK2 |
0.793 | -0.083 | -3 | 0.815 |
MEK1 |
0.792 | -0.155 | 2 | 0.824 |
PLK4 |
0.791 | -0.103 | 2 | 0.639 |
BRSK1 |
0.791 | -0.059 | -3 | 0.784 |
PKCT |
0.791 | -0.008 | 2 | 0.720 |
WNK4 |
0.790 | -0.079 | -2 | 0.857 |
ACVR2A |
0.790 | -0.082 | -2 | 0.753 |
PAK4 |
0.790 | 0.081 | -2 | 0.764 |
SMG1 |
0.790 | -0.093 | 1 | 0.402 |
PHKG2 |
0.789 | -0.049 | -3 | 0.794 |
GSK3A |
0.789 | 0.159 | 4 | 0.381 |
DCAMKL1 |
0.789 | -0.029 | -3 | 0.774 |
ACVR2B |
0.789 | -0.088 | -2 | 0.760 |
CAMK2B |
0.789 | -0.087 | 2 | 0.747 |
GRK4 |
0.789 | -0.198 | -2 | 0.763 |
TTBK2 |
0.789 | -0.225 | 2 | 0.692 |
CHK1 |
0.788 | -0.083 | -3 | 0.809 |
CHAK1 |
0.787 | -0.169 | 2 | 0.760 |
TLK2 |
0.787 | -0.130 | 1 | 0.369 |
CAMK2A |
0.787 | -0.057 | 2 | 0.756 |
IRAK4 |
0.787 | -0.109 | 1 | 0.370 |
ALK2 |
0.787 | -0.081 | -2 | 0.753 |
PKCI |
0.787 | 0.004 | 2 | 0.726 |
SNRK |
0.786 | -0.140 | 2 | 0.682 |
P70S6K |
0.786 | 0.002 | -3 | 0.717 |
TAO3 |
0.786 | -0.036 | 1 | 0.431 |
SMMLCK |
0.786 | 0.028 | -3 | 0.815 |
MARK1 |
0.786 | -0.068 | 4 | 0.804 |
MST3 |
0.786 | -0.049 | 2 | 0.809 |
HRI |
0.786 | -0.163 | -2 | 0.812 |
MLK4 |
0.785 | -0.143 | 2 | 0.695 |
MEK5 |
0.785 | -0.171 | 2 | 0.812 |
CAMK1G |
0.785 | -0.048 | -3 | 0.773 |
PERK |
0.784 | -0.151 | -2 | 0.786 |
SGK1 |
0.784 | 0.092 | -3 | 0.608 |
DRAK1 |
0.783 | -0.140 | 1 | 0.372 |
MEKK1 |
0.783 | -0.166 | 1 | 0.405 |
NEK5 |
0.783 | -0.141 | 1 | 0.397 |
BMPR1A |
0.783 | -0.046 | 1 | 0.370 |
AKT3 |
0.783 | 0.080 | -3 | 0.623 |
BRAF |
0.783 | -0.131 | -4 | 0.841 |
SSTK |
0.783 | -0.040 | 4 | 0.826 |
MEKK2 |
0.782 | -0.135 | 2 | 0.793 |
ZAK |
0.782 | -0.174 | 1 | 0.385 |
MRCKA |
0.781 | 0.080 | -3 | 0.759 |
DCAMKL2 |
0.781 | -0.056 | -3 | 0.803 |
PKCE |
0.780 | 0.025 | 2 | 0.699 |
MAPKAPK5 |
0.780 | -0.110 | -3 | 0.728 |
DAPK3 |
0.780 | 0.048 | -3 | 0.796 |
MRCKB |
0.780 | 0.080 | -3 | 0.739 |
PLK3 |
0.780 | -0.154 | 2 | 0.740 |
TAO2 |
0.779 | -0.059 | 2 | 0.829 |
LKB1 |
0.779 | -0.049 | -3 | 0.849 |
GAK |
0.778 | -0.027 | 1 | 0.470 |
PKN1 |
0.778 | -0.014 | -3 | 0.730 |
MEKK3 |
0.778 | -0.206 | 1 | 0.412 |
GRK2 |
0.777 | -0.119 | -2 | 0.655 |
ROCK2 |
0.776 | 0.068 | -3 | 0.779 |
PBK |
0.776 | 0.002 | 1 | 0.433 |
PDK1 |
0.776 | -0.063 | 1 | 0.430 |
GSK3B |
0.775 | 0.007 | 4 | 0.376 |
NEK8 |
0.775 | -0.153 | 2 | 0.801 |
CAMK1D |
0.774 | -0.023 | -3 | 0.690 |
CK1E |
0.774 | -0.047 | -3 | 0.545 |
MEKK6 |
0.774 | -0.099 | 1 | 0.400 |
NEK11 |
0.774 | -0.165 | 1 | 0.414 |
TLK1 |
0.774 | -0.171 | -2 | 0.773 |
PASK |
0.774 | -0.071 | -3 | 0.835 |
MAP3K15 |
0.774 | -0.097 | 1 | 0.398 |
LOK |
0.773 | -0.049 | -2 | 0.771 |
DAPK1 |
0.773 | 0.035 | -3 | 0.781 |
DMPK1 |
0.773 | 0.115 | -3 | 0.755 |
GCK |
0.773 | -0.091 | 1 | 0.405 |
HGK |
0.772 | -0.084 | 3 | 0.856 |
PKG1 |
0.772 | 0.053 | -2 | 0.696 |
SBK |
0.772 | 0.109 | -3 | 0.577 |
TNIK |
0.772 | -0.055 | 3 | 0.862 |
NEK4 |
0.770 | -0.157 | 1 | 0.374 |
MINK |
0.770 | -0.123 | 1 | 0.380 |
BUB1 |
0.769 | 0.007 | -5 | 0.744 |
KHS1 |
0.768 | -0.050 | 1 | 0.387 |
CAMKK2 |
0.768 | -0.162 | -2 | 0.720 |
NEK1 |
0.768 | -0.127 | 1 | 0.377 |
HPK1 |
0.768 | -0.083 | 1 | 0.398 |
PDHK3_TYR |
0.768 | 0.128 | 4 | 0.841 |
CAMKK1 |
0.767 | -0.219 | -2 | 0.713 |
LRRK2 |
0.767 | -0.072 | 2 | 0.825 |
MST2 |
0.767 | -0.153 | 1 | 0.397 |
CHK2 |
0.766 | -0.016 | -3 | 0.634 |
IRAK1 |
0.766 | -0.231 | -1 | 0.794 |
KHS2 |
0.766 | -0.030 | 1 | 0.399 |
CK2A2 |
0.765 | -0.064 | 1 | 0.349 |
EEF2K |
0.765 | -0.111 | 3 | 0.817 |
YSK1 |
0.765 | -0.101 | 2 | 0.798 |
NEK3 |
0.765 | -0.094 | 1 | 0.391 |
CK1D |
0.765 | -0.033 | -3 | 0.498 |
LIMK2_TYR |
0.764 | 0.141 | -3 | 0.884 |
CAMK1A |
0.764 | -0.008 | -3 | 0.648 |
TTBK1 |
0.764 | -0.198 | 2 | 0.610 |
ROCK1 |
0.764 | 0.059 | -3 | 0.753 |
SLK |
0.763 | -0.083 | -2 | 0.713 |
CK1G1 |
0.763 | -0.087 | -3 | 0.538 |
VRK1 |
0.762 | -0.177 | 2 | 0.835 |
CRIK |
0.762 | 0.052 | -3 | 0.701 |
HASPIN |
0.762 | 0.010 | -1 | 0.736 |
TESK1_TYR |
0.762 | 0.035 | 3 | 0.880 |
CK1A2 |
0.761 | -0.046 | -3 | 0.497 |
TAK1 |
0.761 | -0.196 | 1 | 0.392 |
MEK2 |
0.761 | -0.183 | 2 | 0.814 |
MST1 |
0.761 | -0.154 | 1 | 0.380 |
RIPK2 |
0.761 | -0.201 | 1 | 0.374 |
PKMYT1_TYR |
0.761 | 0.117 | 3 | 0.846 |
GRK3 |
0.759 | -0.126 | -2 | 0.612 |
MAP2K4_TYR |
0.756 | -0.027 | -1 | 0.924 |
PDHK4_TYR |
0.756 | 0.012 | 2 | 0.845 |
BIKE |
0.756 | -0.023 | 1 | 0.433 |
MAP2K7_TYR |
0.755 | -0.087 | 2 | 0.839 |
CK2A1 |
0.755 | -0.079 | 1 | 0.335 |
TAO1 |
0.754 | -0.079 | 1 | 0.381 |
MAP2K6_TYR |
0.753 | -0.026 | -1 | 0.923 |
STK33 |
0.753 | -0.157 | 2 | 0.590 |
LIMK1_TYR |
0.753 | 0.006 | 2 | 0.841 |
MYO3B |
0.753 | -0.067 | 2 | 0.809 |
PINK1_TYR |
0.752 | -0.125 | 1 | 0.467 |
TTK |
0.752 | -0.076 | -2 | 0.789 |
OSR1 |
0.751 | -0.100 | 2 | 0.782 |
AAK1 |
0.750 | 0.017 | 1 | 0.408 |
RET |
0.749 | -0.115 | 1 | 0.416 |
BMPR2_TYR |
0.749 | -0.035 | -1 | 0.894 |
MST1R |
0.748 | -0.082 | 3 | 0.820 |
PDHK1_TYR |
0.748 | -0.104 | -1 | 0.926 |
ROS1 |
0.747 | -0.101 | 3 | 0.783 |
ASK1 |
0.747 | -0.150 | 1 | 0.396 |
TYK2 |
0.747 | -0.172 | 1 | 0.402 |
MYO3A |
0.747 | -0.095 | 1 | 0.380 |
JAK2 |
0.746 | -0.112 | 1 | 0.417 |
NEK10_TYR |
0.746 | -0.073 | 1 | 0.379 |
EPHA6 |
0.745 | -0.090 | -1 | 0.879 |
PLK2 |
0.744 | -0.139 | -3 | 0.738 |
TNNI3K_TYR |
0.744 | -0.017 | 1 | 0.423 |
DDR1 |
0.744 | -0.090 | 4 | 0.802 |
TNK1 |
0.743 | -0.029 | 3 | 0.786 |
CSF1R |
0.743 | -0.098 | 3 | 0.805 |
TYRO3 |
0.742 | -0.155 | 3 | 0.807 |
EPHB4 |
0.741 | -0.125 | -1 | 0.867 |
JAK1 |
0.741 | -0.072 | 1 | 0.383 |
JAK3 |
0.741 | -0.118 | 1 | 0.415 |
YES1 |
0.740 | -0.089 | -1 | 0.880 |
ABL2 |
0.739 | -0.109 | -1 | 0.848 |
FGFR2 |
0.738 | -0.050 | 3 | 0.802 |
FGFR1 |
0.737 | -0.041 | 3 | 0.778 |
TXK |
0.737 | -0.089 | 1 | 0.398 |
ALPHAK3 |
0.737 | -0.116 | -1 | 0.811 |
ABL1 |
0.736 | -0.110 | -1 | 0.840 |
FGR |
0.736 | -0.171 | 1 | 0.412 |
KDR |
0.735 | -0.076 | 3 | 0.779 |
TNK2 |
0.735 | -0.115 | 3 | 0.759 |
INSRR |
0.734 | -0.136 | 3 | 0.759 |
TEK |
0.734 | -0.041 | 3 | 0.735 |
STLK3 |
0.733 | -0.190 | 1 | 0.369 |
LCK |
0.733 | -0.105 | -1 | 0.848 |
FLT3 |
0.733 | -0.156 | 3 | 0.801 |
PDGFRB |
0.732 | -0.187 | 3 | 0.811 |
HCK |
0.732 | -0.154 | -1 | 0.852 |
BLK |
0.731 | -0.087 | -1 | 0.856 |
FER |
0.730 | -0.212 | 1 | 0.414 |
DDR2 |
0.730 | -0.012 | 3 | 0.740 |
YANK3 |
0.730 | -0.086 | 2 | 0.367 |
ITK |
0.730 | -0.154 | -1 | 0.829 |
EPHB1 |
0.728 | -0.183 | 1 | 0.393 |
AXL |
0.728 | -0.170 | 3 | 0.790 |
MERTK |
0.728 | -0.149 | 3 | 0.794 |
EPHA4 |
0.728 | -0.130 | 2 | 0.727 |
KIT |
0.728 | -0.158 | 3 | 0.796 |
WEE1_TYR |
0.727 | -0.095 | -1 | 0.786 |
EPHB2 |
0.727 | -0.156 | -1 | 0.840 |
PDGFRA |
0.727 | -0.206 | 3 | 0.808 |
EPHB3 |
0.727 | -0.180 | -1 | 0.848 |
SRMS |
0.725 | -0.211 | 1 | 0.391 |
FGFR3 |
0.725 | -0.079 | 3 | 0.777 |
MET |
0.724 | -0.137 | 3 | 0.797 |
ALK |
0.724 | -0.158 | 3 | 0.726 |
BTK |
0.723 | -0.216 | -1 | 0.799 |
TEC |
0.722 | -0.156 | -1 | 0.776 |
BMX |
0.722 | -0.136 | -1 | 0.746 |
EPHA1 |
0.721 | -0.156 | 3 | 0.780 |
NTRK2 |
0.720 | -0.200 | 3 | 0.766 |
LTK |
0.720 | -0.174 | 3 | 0.749 |
FYN |
0.719 | -0.114 | -1 | 0.824 |
INSR |
0.718 | -0.167 | 3 | 0.727 |
PTK2B |
0.718 | -0.114 | -1 | 0.810 |
ERBB2 |
0.718 | -0.192 | 1 | 0.382 |
EPHA7 |
0.718 | -0.157 | 2 | 0.733 |
FLT4 |
0.718 | -0.166 | 3 | 0.758 |
FRK |
0.717 | -0.171 | -1 | 0.862 |
NTRK1 |
0.717 | -0.233 | -1 | 0.859 |
CK1A |
0.717 | -0.091 | -3 | 0.409 |
FLT1 |
0.717 | -0.166 | -1 | 0.856 |
PTK6 |
0.716 | -0.227 | -1 | 0.766 |
EPHA3 |
0.714 | -0.185 | 2 | 0.708 |
NTRK3 |
0.714 | -0.180 | -1 | 0.809 |
LYN |
0.713 | -0.178 | 3 | 0.703 |
EGFR |
0.711 | -0.134 | 1 | 0.338 |
MUSK |
0.711 | -0.145 | 1 | 0.332 |
SRC |
0.710 | -0.151 | -1 | 0.829 |
EPHA5 |
0.708 | -0.178 | 2 | 0.712 |
EPHA8 |
0.707 | -0.160 | -1 | 0.822 |
MATK |
0.707 | -0.148 | -1 | 0.770 |
FGFR4 |
0.704 | -0.146 | -1 | 0.800 |
PTK2 |
0.703 | -0.100 | -1 | 0.790 |
CSK |
0.702 | -0.203 | 2 | 0.743 |
IGF1R |
0.700 | -0.174 | 3 | 0.660 |
EPHA2 |
0.697 | -0.167 | -1 | 0.786 |
SYK |
0.697 | -0.136 | -1 | 0.785 |
ERBB4 |
0.697 | -0.127 | 1 | 0.337 |
CK1G3 |
0.694 | -0.096 | -3 | 0.361 |
YANK2 |
0.691 | -0.121 | 2 | 0.381 |
FES |
0.688 | -0.166 | -1 | 0.725 |
ZAP70 |
0.684 | -0.099 | -1 | 0.709 |
CK1G2 |
0.670 | -0.112 | -3 | 0.456 |