Motif 823 (n=186)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0B4J269 | None | S462 | ochoa | Melanocyte-stimulating hormone receptor (Melanocortin receptor 1) | Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes. {ECO:0000256|ARBA:ARBA00023428}. |
| A0JNW5 | BLTP3B | S1081 | ochoa | Bridge-like lipid transfer protein family member 3B (Syntaxin-6 Habc-interacting protein of 164 kDa) (UHRF1-binding protein 1-like) | Tube-forming lipid transport protein which mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567). Required for retrograde traffic of vesicle clusters in the early endocytic pathway to the Golgi complex (PubMed:20163565, PubMed:35499567). {ECO:0000269|PubMed:20163565, ECO:0000269|PubMed:35499567}. |
| A6NF01 | POM121B | S127 | ochoa | Putative nuclear envelope pore membrane protein POM 121B | Putative component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane (By similarity). {ECO:0000250}. |
| A8CG34 | POM121C | S520 | ochoa | Nuclear envelope pore membrane protein POM 121C (Nuclear pore membrane protein 121-2) (POM121-2) (Pore membrane protein of 121 kDa C) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| C9J798 | RASA4B | S588 | ochoa | Ras GTPase-activating protein 4B | Ca(2+)-dependent Ras GTPase-activating protein, that may play a role in the Ras-MAPK pathway. {ECO:0000250|UniProtKB:O43374}. |
| O00299 | CLIC1 | S121 | ochoa | Chloride intracellular channel protein 1 (Chloride channel ABP) (Glutaredoxin-like oxidoreductase CLIC1) (EC 1.8.-.-) (Glutathione-dependent dehydroascorbate reductase CLIC1) (EC 1.8.5.1) (Nuclear chloride ion channel 27) (NCC27) (Regulatory nuclear chloride ion channel protein) (hRNCC) | In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Reduces selenite and dehydroascorbate and may act as an antioxidant during oxidative stress response (PubMed:25581026, PubMed:37759794). Can insert into membranes and form voltage-dependent multi-ion conductive channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions. Involved in regulation of the cell cycle. {ECO:0000269|PubMed:10834939, ECO:0000269|PubMed:10874038, ECO:0000269|PubMed:11195932, ECO:0000269|PubMed:11551966, ECO:0000269|PubMed:11940526, ECO:0000269|PubMed:11978800, ECO:0000269|PubMed:14613939, ECO:0000269|PubMed:16339885, ECO:0000269|PubMed:25581026, ECO:0000269|PubMed:37759794, ECO:0000269|PubMed:9139710}. |
| O00444 | PLK4 | S305 | psp | Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase 18) (Serine/threonine-protein kinase Sak) | Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (PubMed:22020124). Phosphorylates CEP131 at 'Ser-78' and PCM1 at 'Ser-372' which is essential for proper organization and integrity of centriolar satellites (PubMed:30804208). {ECO:0000269|PubMed:16244668, ECO:0000269|PubMed:16326102, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:18239451, ECO:0000269|PubMed:19164942, ECO:0000269|PubMed:21725316, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:27796307, ECO:0000269|PubMed:30804208}. |
| O14976 | GAK | S1176 | ochoa | Cyclin-G-associated kinase (EC 2.7.11.1) (DnaJ homolog subfamily C member 26) | Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 (PubMed:10625686). May play a role in clathrin-mediated endocytosis and intracellular trafficking, and in the dynamics of clathrin assembly/disassembly (PubMed:18489706). {ECO:0000269|PubMed:10625686, ECO:0000269|PubMed:18489706}. |
| O15020 | SPTBN2 | S1073 | ochoa | Spectrin beta chain, non-erythrocytic 2 (Beta-III spectrin) (Spinocerebellar ataxia 5 protein) | Probably plays an important role in neuronal membrane skeleton. |
| O43172 | PRPF4 | S185 | ochoa | U4/U6 small nuclear ribonucleoprotein Prp4 (PRP4 homolog) (hPrp4) (U4/U6 snRNP 60 kDa protein) (WD splicing factor Prp4) | Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). {ECO:0000269|PubMed:25383878, ECO:0000269|PubMed:28781166}. |
| O43242 | PSMD3 | S418 | ochoa | 26S proteasome non-ATPase regulatory subunit 3 (26S proteasome regulatory subunit RPN3) (26S proteasome regulatory subunit S3) (Proteasome subunit p58) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. {ECO:0000269|PubMed:1317798}. |
| O43374 | RASA4 | S588 | ochoa | Ras GTPase-activating protein 4 (Calcium-promoted Ras inactivator) (Ras p21 protein activator 4) (RasGAP-activating-like protein 2) | Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis. {ECO:0000269|PubMed:11448776}. |
| O60293 | ZFC3H1 | S503 | ochoa | Zinc finger C3H1 domain-containing protein (Coiled-coil domain-containing protein 131) (Proline/serine-rich coiled-coil protein 2) | Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters. {ECO:0000269|PubMed:27871484}. |
| O60503 | ADCY9 | S688 | ochoa | Adenylate cyclase type 9 (EC 4.6.1.1) (ATP pyrophosphate-lyase 9) (Adenylate cyclase type IX) (ACIX) (Adenylyl cyclase 9) (AC9) | Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors (PubMed:10987815, PubMed:12972952, PubMed:15879435, PubMed:9628827). Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors (PubMed:9628827). {ECO:0000269|PubMed:10987815, ECO:0000269|PubMed:12972952, ECO:0000269|PubMed:15879435, ECO:0000269|PubMed:9628827}. |
| O75038 | PLCH2 | S1256 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-eta-2) (Phosphoinositide phospholipase C-like 4) (PLC-L4) (Phospholipase C-like protein 4) (Phospholipase C-eta-2) (PLC-eta2) | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (PubMed:18361507). This phospholipase activity is very sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain (By similarity). {ECO:0000250|UniProtKB:A2AP18, ECO:0000269|PubMed:18361507}. |
| O75363 | BCAS1 | S552 | ochoa | Breast carcinoma-amplified sequence 1 (Amplified and overexpressed in breast cancer) (Novel amplified in breast cancer 1) | Required for myelination. {ECO:0000250|UniProtKB:Q80YN3}. |
| O75369 | FLNB | S1912 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| O94887 | FARP2 | S375 | ochoa | FERM, ARHGEF and pleckstrin domain-containing protein 2 (FERM domain-including RhoGEF) (FIR) (FERM, RhoGEF and pleckstrin domain-containing protein 2) (Pleckstrin homology domain-containing family C member 3) (PH domain-containing family C member 3) | Functions as a guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity). {ECO:0000250}. |
| O94929 | ABLIM3 | S163 | ochoa | Actin-binding LIM protein 3 (abLIM-3) (Actin-binding LIM protein family member 3) | May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity. {ECO:0000269|PubMed:17194709}. |
| O95453 | PARN | S342 | ochoa | Poly(A)-specific ribonuclease PARN (EC 3.1.13.4) (Deadenylating nuclease) (Deadenylation nuclease) (Polyadenylate-specific ribonuclease) | 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization (PubMed:10882133, PubMed:11359775, PubMed:12748283, PubMed:15175153, PubMed:9736620). Also able to recognize and trim poly(A) tails of microRNAs such as MIR21 and H/ACA box snoRNAs (small nucleolar RNAs) leading to microRNAs degradation or snoRNA increased stability (PubMed:22442037, PubMed:25049417). {ECO:0000269|PubMed:10882133, ECO:0000269|PubMed:11359775, ECO:0000269|PubMed:12748283, ECO:0000269|PubMed:15175153, ECO:0000269|PubMed:22442037, ECO:0000269|PubMed:25049417, ECO:0000269|PubMed:9736620}. |
| O95573 | ACSL3 | S73 | ochoa | Fatty acid CoA ligase Acsl3 (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 3) (LACS 3) (Long-chain-fatty-acid--CoA ligase 3) (EC 6.2.1.3) (Medium-chain acyl-CoA ligase Acsl3) (EC 6.2.1.2) | Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:22633490). Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins) (PubMed:18003621). Has mainly an anabolic role in energy metabolism. Mediates hepatic lipogenesis. Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates. Both isoforms exhibit the same level of activity (By similarity). {ECO:0000250|UniProtKB:Q63151, ECO:0000269|PubMed:18003621, ECO:0000269|PubMed:22633490}. |
| O95613 | PCNT | S3014 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| P01009 | SERPINA1 | S261 | ochoa | Alpha-1-antitrypsin (Alpha-1 protease inhibitor) (Alpha-1-antiproteinase) (Serpin A1) [Cleaved into: Short peptide from AAT (SPAAT)] | Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.; FUNCTION: [Short peptide from AAT]: Reversible chymotrypsin inhibitor. It also inhibits elastase, but not trypsin. Its major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE). |
| P02730 | SLC4A1 | S303 | psp | Band 3 anion transport protein (Anion exchange protein 1) (AE 1) (Anion exchanger 1) (Solute carrier family 4 member 1) (CD antigen CD233) | Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein (PubMed:10926824, PubMed:14734552, PubMed:1538405, PubMed:16227998, PubMed:20151848, PubMed:24121512, PubMed:28387307, PubMed:35835865). Component of the ankyrin-1 complex of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin (PubMed:1538405, PubMed:20151848, PubMed:35835865). Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine (PubMed:10926824, PubMed:14734552, PubMed:16227998, PubMed:24121512, PubMed:28387307). {ECO:0000269|PubMed:10926824, ECO:0000269|PubMed:14734552, ECO:0000269|PubMed:1538405, ECO:0000269|PubMed:16227998, ECO:0000269|PubMed:20151848, ECO:0000269|PubMed:24121512, ECO:0000269|PubMed:28387307, ECO:0000269|PubMed:35835865}.; FUNCTION: (Microbial infection) Acts as a receptor for P.falciparum (isolate 3D7) MSP9 and thus, facilitates merozoite invasion of erythrocytes (PubMed:14630931). Acts as a receptor for P.falciparum (isolate 3D7) MSP1 and thus, facilitates merozoite invasion of erythrocytes (PubMed:12692305). {ECO:0000269|PubMed:12692305, ECO:0000269|PubMed:14630931}. |
| P04035 | HMGCR | S421 | ochoa | 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) (EC 1.1.1.34) | Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis (PubMed:21357570, PubMed:2991281, PubMed:36745799, PubMed:6995544). HMGCR is the main target of statins, a class of cholesterol-lowering drugs (PubMed:11349148, PubMed:18540668, PubMed:36745799). {ECO:0000269|PubMed:11349148, ECO:0000269|PubMed:18540668, ECO:0000269|PubMed:21357570, ECO:0000269|PubMed:2991281, ECO:0000269|PubMed:36745799, ECO:0000269|PubMed:6995544}. |
| P07437 | TUBB | S115 | ochoa | Tubulin beta chain (Tubulin beta-5 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P08651 | NFIC | S248 | ochoa | Nuclear factor 1 C-type (NF1-C) (Nuclear factor 1/C) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/C) (NF-I/C) (NFI-C) (TGGCA-binding protein) | Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. |
| P10412 | H1-4 | S58 | ochoa | Histone H1.4 (Histone H1b) (Histone H1s-4) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P10809 | HSPD1 | S253 | ochoa | 60 kDa heat shock protein, mitochondrial (EC 5.6.1.7) (60 kDa chaperonin) (Chaperonin 60) (CPN60) (Heat shock protein 60) (HSP-60) (Hsp60) (Heat shock protein family D member 1) (HuCHA60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) | Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:11422376, PubMed:1346131). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). {ECO:0000269|PubMed:11422376, ECO:0000269|PubMed:1346131, ECO:0000305|PubMed:25918392}. |
| P11055 | MYH3 | S643 | ochoa | Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE) | Muscle contraction. |
| P12882 | MYH1 | S646 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12883 | MYH7 | S642 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P12956 | XRCC6 | S520 | ochoa | X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6) | Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Required for double-strand break repair and V(D)J recombination (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Also has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). It works in the 3'-5' direction (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Binding to DNA may be mediated by XRCC6 (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The XRCC5-XRRC6 dimer acts as a regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks (PubMed:20383123). 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined (PubMed:20383123). The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488). In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:12145306). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Negatively regulates apoptosis by interacting with BAX and sequestering it from the mitochondria (PubMed:15023334). Might have deubiquitination activity, acting on BAX (PubMed:18362350). {ECO:0000269|PubMed:11493912, ECO:0000269|PubMed:12145306, ECO:0000269|PubMed:15023334, ECO:0000269|PubMed:18362350, ECO:0000269|PubMed:20383123, ECO:0000269|PubMed:20493174, ECO:0000269|PubMed:2466842, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:7957065, ECO:0000269|PubMed:8621488, ECO:0000269|PubMed:9742108}. |
| P13533 | MYH6 | S644 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P13535 | MYH8 | S645 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
| P13807 | GYS1 | S412 | ochoa | Glycogen [starch] synthase, muscle (EC 2.4.1.11) (Glycogen synthase 1) | Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. {ECO:0000269|PubMed:35835870}. |
| P15259 | PGAM2 | S189 | ochoa | Phosphoglycerate mutase 2 (EC 5.4.2.11) (EC 5.4.2.4) (BPG-dependent PGAM 2) (Muscle-specific phosphoglycerate mutase) (Phosphoglycerate mutase isozyme M) (PGAM-M) | Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase), but with a reduced activity. |
| P16401 | H1-5 | S61 | ochoa | Histone H1.5 (Histone H1a) (Histone H1b) (Histone H1s-3) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P16402 | H1-3 | S59 | ochoa | Histone H1.3 (Histone H1c) (Histone H1s-2) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P16403 | H1-2 | S58 | ochoa | Histone H1.2 (Histone H1c) (Histone H1d) (Histone H1s-1) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P17655 | CAPN2 | S50 | psp | Calpain-2 catalytic subunit (EC 3.4.22.53) (Calcium-activated neutral proteinase 2) (CANP 2) (Calpain M-type) (Calpain large polypeptide L2) (Calpain-2 large subunit) (Millimolar-calpain) (M-calpain) | Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226' (PubMed:17650508). Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs (By similarity). {ECO:0000250|UniProtKB:O08529, ECO:0000269|PubMed:17650508}. |
| P17947 | SPI1 | S106 | ochoa | Transcription factor PU.1 (31 kDa-transforming protein) | Pioneer transcription factor, which controls hematopoietic cell fate by decompacting stem cell heterochromatin and allowing other transcription factors to enter otherwise inaccessible genomic sites. Once in open chromatin, can directly control gene expression by binding genetic regulatory elements and can also more broadly influence transcription by recruiting transcription factors, such as interferon regulatory factors (IRFs), to otherwise inaccessible genomic regions (PubMed:23658224, PubMed:33951726). Transcriptionally activates genes important for myeloid and lymphoid lineages, such as CSF1R (By similarity). Transcriptional activation from certain promoters, possibly containing low affinity binding sites, is achieved cooperatively with other transcription factors. FCER1A transactivation is achieved in cooperation with GATA1 (By similarity). May be particularly important for the pro- to pre-B cell transition (PubMed:33951726). Binds (via the ETS domain) onto the purine-rich DNA core sequence 5'-GAGGAA-3', also known as the PU-box (PubMed:33951726). In vitro can bind RNA and interfere with pre-mRNA splicing (By similarity). {ECO:0000250|UniProtKB:P17433, ECO:0000250|UniProtKB:Q6BDS1, ECO:0000269|PubMed:23658224, ECO:0000269|PubMed:33951726}. |
| P20337 | RAB3B | S190 | ochoa | Ras-related protein Rab-3B (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:35871249). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:35871249). {ECO:0000269|PubMed:35871249}. |
| P20585 | MSH3 | S155 | ochoa | DNA mismatch repair protein Msh3 (hMSH3) (Divergent upstream protein) (DUP) (Mismatch repair protein 1) (MRP1) | Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. |
| P21333 | FLNA | S1967 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P22314 | UBA1 | S46 | ochoa | Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1) | Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1447181, PubMed:1606621, PubMed:33108101). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334). {ECO:0000269|PubMed:1447181, ECO:0000269|PubMed:1606621, ECO:0000269|PubMed:22456334, ECO:0000269|PubMed:33108101}. |
| P23458 | JAK1 | S518 | psp | Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1) | Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:16239216, PubMed:28111307, PubMed:32750333, PubMed:7615558, PubMed:8232552). Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529) as well as interleukin (IL)-10 receptor (PubMed:12133952). Kinase partner for the type I interferon receptor IFNAR2 (PubMed:16239216, PubMed:28111307, PubMed:32750333, PubMed:7615558, PubMed:8232552). In response to interferon-binding to IFNAR1-IFNAR2 heterodimer, phosphorylates and activates its binding partner IFNAR2, creating docking sites for STAT proteins (PubMed:7759950). Directly phosphorylates STAT proteins but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors (PubMed:16239216, PubMed:32750333, PubMed:8232552). {ECO:0000269|PubMed:11909529, ECO:0000269|PubMed:12133952, ECO:0000269|PubMed:16239216, ECO:0000269|PubMed:28111307, ECO:0000269|PubMed:32750333, ECO:0000269|PubMed:7615558, ECO:0000269|PubMed:7657660, ECO:0000269|PubMed:8232552}. |
| P24723 | PRKCH | S32 | ochoa|psp | Protein kinase C eta type (EC 2.7.11.13) (PKC-L) (nPKC-eta) | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis. Promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria. Phosphorylates ATF2 which promotes its nuclear retention and transcriptional activity and negatively regulates its mitochondrial localization. {ECO:0000269|PubMed:10806212, ECO:0000269|PubMed:11112424, ECO:0000269|PubMed:11772428, ECO:0000269|PubMed:15489897, ECO:0000269|PubMed:17146445, ECO:0000269|PubMed:18780722, ECO:0000269|PubMed:19114660, ECO:0000269|PubMed:20558593, ECO:0000269|PubMed:21820409, ECO:0000269|PubMed:22304920}. |
| P26373 | RPL13 | S109 | ochoa | Large ribosomal subunit protein eL13 (60S ribosomal protein L13) (Breast basic conserved protein 1) | Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:31630789, PubMed:32669547). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (Probable). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (Probable). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (Probable). As part of the LSU, it is probably required for its formation and the maturation of rRNAs (PubMed:31630789). Plays a role in bone development (PubMed:31630789). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:31630789, ECO:0000269|PubMed:32669547}. |
| P27815 | PDE4A | S567 | ochoa | 3',5'-cyclic-AMP phosphodiesterase 4A (EC 3.1.4.53) (DPDE2) (PDE46) (cAMP-specific phosphodiesterase 4A) | Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:11566027, ECO:0000269|PubMed:2160582}.; FUNCTION: [Isoform 1]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310}.; FUNCTION: [Isoform 2]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:15738310}.; FUNCTION: [Isoform 3]: Efficiently hydrolyzes cAMP. The phosphodiesterase activity is not affected by calcium, calmodulin or cyclic GMP (cGMP) levels. Does not hydrolyze cGMP. {ECO:0000269|PubMed:7888306}.; FUNCTION: [Isoform 4]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:9677330}.; FUNCTION: [Isoform 6]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310, ECO:0000269|PubMed:17727341}.; FUNCTION: [Isoform 7]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:18095939}. |
| P28838 | LAP3 | S194 | ochoa | Cytosol aminopeptidase (EC 3.4.11.1) (Cysteinylglycine-S-conjugate dipeptidase) (EC 3.4.13.23) (Leucine aminopeptidase 3) (LAP-3) (Leucyl aminopeptidase) (Peptidase S) (Proline aminopeptidase) (EC 3.4.11.5) (Prolyl aminopeptidase) | Cytosolic metallopeptidase that catalyzes the removal of unsubstituted N-terminal hydrophobic amino acids from various peptides. The presence of Zn(2+) ions is essential for the peptidase activity, and the association with other cofactors can modulate the substrate spectificity of the enzyme. For instance, in the presence of Mn(2+), it displays a specific Cys-Gly hydrolyzing activity of Cys-Gly-S-conjugates. Involved in the metabolism of glutathione and in the degradation of glutathione S-conjugates, which may play a role in the control of the cell redox status. {ECO:0000250|UniProtKB:P00727}. |
| P29474 | NOS3 | S634 | ochoa | Nitric oxide synthase 3 (EC 1.14.13.39) (Constitutive NOS) (cNOS) (EC-NOS) (NOS type III) (NOSIII) (Nitric oxide synthase, endothelial) (Endothelial NOS) (eNOS) | Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway (PubMed:1378832). NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. {ECO:0000269|PubMed:1378832}.; FUNCTION: [Isoform eNOS13C]: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1. |
| P31327 | CPS1 | S835 | ochoa | Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I) | Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. |
| P33121 | ACSL1 | S423 | ochoa | Long-chain-fatty-acid--CoA ligase 1 (EC 6.2.1.3) (Acyl-CoA synthetase 1) (ACS1) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 1) (LACS 1) (Long-chain acyl-CoA synthetase 2) (LACS 2) (Long-chain fatty acid-CoA ligase 2) (Palmitoyl-CoA ligase 1) (Palmitoyl-CoA ligase 2) (Phytanate--CoA ligase) (EC 6.2.1.24) | Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:21242590, PubMed:22633490, PubMed:24269233). Preferentially uses palmitoleate, oleate and linoleate (PubMed:24269233). Preferentially activates arachidonate than epoxyeicosatrienoic acids (EETs) or hydroxyeicosatrienoic acids (HETEs) (By similarity). {ECO:0000250|UniProtKB:P18163, ECO:0000269|PubMed:21242590, ECO:0000269|PubMed:22633490, ECO:0000269|PubMed:24269233}. |
| P35711 | SOX5 | S138 | ochoa | Transcription factor SOX-5 | Transcription factor involved in chondrocytes differentiation and cartilage formation. Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including cartilage matrix protein-coding genes, such as COL2A1 and AGC1. Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate. Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes. Together with SOX6, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts. Binds to the proximal promoter region of the myelin protein MPZ gene. {ECO:0000250|UniProtKB:P35710}. |
| P35712 | SOX6 | S126 | ochoa | Transcription factor SOX-6 | Transcription factor that plays a key role in several developmental processes, including neurogenesis, chondrocytes differentiation and cartilage formation (Probable). Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis. Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate. Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes. Together with SOX5, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts. Binds to the proximal promoter region of the myelin protein MPZ gene, and is thereby involved in the differentiation of oligodendroglia in the developing spinal tube. Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity). {ECO:0000250|UniProtKB:P40645, ECO:0000305|PubMed:32442410}. |
| P40238 | MPL | S531 | ochoa | Thrombopoietin receptor (TPO-R) (Myeloproliferative leukemia protein) (Proto-oncogene c-Mpl) (CD antigen CD110) | Receptor for thrombopoietin that regulates hematopoietic stem cell renewal, megakaryocyte differentiation, and platelet formation. Upon activation by THPO, induces rapid tyrosine phosphorylation and activation of JAK2, providing docking sites for many signaling proteins such as STAT5, SHIP/INPP5D, GRB2, SOS1 and PI3K (PubMed:15899890, PubMed:37633268). In turn, These signaling cascades lead to the proliferation, survival, and differentiation of megakaryocytes, ultimately leading to increased platelet production. {ECO:0000269|PubMed:15899890, ECO:0000269|PubMed:37633268}. |
| P41235 | HNF4A | S148 | ochoa | Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) (TCF-14) (Transcription factor HNF-4) | Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes (PubMed:30597922). Activates the transcription of CYP2C38 (By similarity). Represses the CLOCK-BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells (PubMed:30530698). {ECO:0000250|UniProtKB:P49698, ECO:0000269|PubMed:30530698, ECO:0000269|PubMed:30597922}. |
| P41743 | PRKCI | S248 | ochoa | Protein kinase C iota type (EC 2.7.11.13) (Atypical protein kinase C-lambda/iota) (PRKC-lambda/iota) (aPKC-lambda/iota) (nPKC-iota) | Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI(3)K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the subsequent activation of NF-kappa-B and neuronal cell survival. Functions in the organization of the apical domain in epithelial cells by phosphorylating EZR. This step is crucial for activation and normal distribution of EZR at the early stages of intestinal epithelial cell differentiation. Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity. Plays a role in microtubule dynamics in the early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs). In human coronary artery endothelial cells (HCAEC), is activated by saturated fatty acids and mediates lipid-induced apoptosis. Involved in early synaptic long term potentiation phase in CA1 hippocampal cells and short term memory formation (By similarity). {ECO:0000250|UniProtKB:F1M7Y5, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10467349, ECO:0000269|PubMed:10906326, ECO:0000269|PubMed:11042363, ECO:0000269|PubMed:11724794, ECO:0000269|PubMed:12871960, ECO:0000269|PubMed:14684752, ECO:0000269|PubMed:15994303, ECO:0000269|PubMed:18270268, ECO:0000269|PubMed:19327373, ECO:0000269|PubMed:21189248, ECO:0000269|PubMed:21419810, ECO:0000269|PubMed:8226978, ECO:0000269|PubMed:9346882}. |
| P52272 | HNRNPM | S86 | ochoa | Heterogeneous nuclear ribonucleoprotein M (hnRNP M) | Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines. |
| P52565 | ARHGDIA | S47 | ochoa | Rho GDP-dissociation inhibitor 1 (Rho GDI 1) (Rho-GDI alpha) | Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1. {ECO:0000269|PubMed:20400958, ECO:0000269|PubMed:23434736}. |
| P52732 | KIF11 | S540 | ochoa | Kinesin-like protein KIF11 (Kinesin-like protein 1) (Kinesin-like spindle protein HKSP) (Kinesin-related motor protein Eg5) (Thyroid receptor-interacting protein 5) (TR-interacting protein 5) (TRIP-5) | Motor protein required for establishing a bipolar spindle and thus contributing to chromosome congression during mitosis (PubMed:19001501, PubMed:37728657). Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (PubMed:23857769). {ECO:0000269|PubMed:19001501, ECO:0000269|PubMed:23857769}. |
| P54132 | BLM | S539 | ochoa | RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) | ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}. |
| P56589 | PEX3 | S201 | ochoa | Peroxisomal biogenesis factor 3 (Peroxin-3) (Peroxisomal assembly protein PEX3) | Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes. {ECO:0000269|PubMed:10848631, ECO:0000269|PubMed:15007061}. |
| P57679 | EVC | S135 | ochoa | EvC complex member EVC (DWF-1) (Ellis-van Creveld syndrome protein) | Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Involved in endochondral growth and skeletal development. {ECO:0000250|UniProtKB:P57680}. |
| P60174 | TPI1 | S21 | psp | Triosephosphate isomerase (TIM) (EC 5.3.1.1) (Methylglyoxal synthase) (EC 4.2.3.3) (Triose-phosphate isomerase) | Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. {ECO:0000269|PubMed:18562316}.; FUNCTION: It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids. {ECO:0000250|UniProtKB:P00939}. |
| P60891 | PRPS1 | S103 | psp | Ribose-phosphate pyrophosphokinase 1 (EC 2.7.6.1) (PPRibP) (Phosphoribosyl pyrophosphate synthase I) (PRS-I) | Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis. {ECO:0000269|PubMed:16939420, ECO:0000269|PubMed:17701900, ECO:0000269|PubMed:7593598}. |
| P61326 | MAGOH | S106 | ochoa | Protein mago nashi homolog | Required for pre-mRNA splicing as component of the spliceosome (PubMed:11991638). Plays a redundant role with MAGOHB as core component of the exon junction complex (EJC) and in the nonsense-mediated decay (NMD) pathway (PubMed:23917022). The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator PYM1 leading to EJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S pre-initiation complex. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the function is different from the established EJC assembly. {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12730685, ECO:0000269|PubMed:16209946, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:23917022}. |
| P68371 | TUBB4B | S115 | ochoa | Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q06546 | GABPA | S62 | ochoa | GA-binding protein alpha chain (GABP subunit alpha) (Nuclear respiratory factor 2 subunit alpha) (Transcription factor E4TF1-60) | Transcription factor capable of interacting with purine rich repeats (GA repeats). Positively regulates transcription of transcriptional repressor RHIT/ZNF205 (PubMed:22306510). {ECO:0000269|PubMed:22306510}.; FUNCTION: (Microbial infection) Necessary for the expression of the Adenovirus E4 gene. |
| Q06830 | PRDX1 | S30 | ochoa | Peroxiredoxin-1 (EC 1.11.1.24) (Natural killer cell-enhancing factor A) (NKEF-A) (Proliferation-associated gene protein) (PAG) (Thioredoxin peroxidase 2) (Thioredoxin-dependent peroxide reductase 2) (Thioredoxin-dependent peroxiredoxin 1) | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (PubMed:9497357). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity). {ECO:0000250|UniProtKB:P0CB50, ECO:0000269|PubMed:9497357}. |
| Q08499 | PDE4D | S596 | ochoa | 3',5'-cyclic-AMP phosphodiesterase 4D (EC 3.1.4.53) (DPDE3) (PDE43) (cAMP-specific phosphodiesterase 4D) | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:9371713}. |
| Q0JRZ9 | FCHO2 | S373 | ochoa | F-BAR domain only protein 2 | Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor. {ECO:0000269|PubMed:17540576, ECO:0000269|PubMed:20448150, ECO:0000269|PubMed:21762413, ECO:0000269|PubMed:22323290}. |
| Q0VF96 | CGNL1 | S1121 | ochoa | Cingulin-like protein 1 (Junction-associated coiled-coil protein) (Paracingulin) | May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons. {ECO:0000269|PubMed:22891260}. |
| Q12874 | SF3A3 | S292 | ochoa | Splicing factor 3A subunit 3 (SF3a60) (Spliceosome-associated protein 61) (SAP 61) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:10882114, PubMed:11533230, PubMed:32494006, PubMed:34822310, PubMed:8022796). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:10882114, PubMed:11533230, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3A3 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex (PubMed:10882114, PubMed:11533230). Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes (PubMed:29360106, PubMed:30315277). {ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:11533230, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:34822310, ECO:0000269|PubMed:8022796}. |
| Q12912 | IRAG2 | S363 | ochoa | Inositol 1,4,5-triphosphate receptor associated 2 (Lymphoid-restricted membrane protein) (Protein Jaw1) [Cleaved into: Processed inositol 1,4,5-triphosphate receptor associated 2] | Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion. Plays a role in maintaining nuclear shape, maybe as a component of the LINC complex and through interaction with microtubules. Plays a role in the regulation of cellular excitability by regulating the hyperpolarization-activated cyclic nucleotide-gated HCN4 channel activity (By similarity). {ECO:0000250|UniProtKB:Q60664}. |
| Q13021 | MALL | S63 | ochoa | MAL-like protein (Protein BENE) | None |
| Q13428 | TCOF1 | S1069 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q13509 | TUBB3 | S115 | ochoa | Tubulin beta-3 chain (Tubulin beta-4 chain) (Tubulin beta-III) | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:34996871, PubMed:38305685, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:34996871, PubMed:38305685, PubMed:38609661). Below the cap, alpha-beta tubulin heterodimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). TUBB3 plays a critical role in proper axon guidance and maintenance (PubMed:20074521). Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Plays a role in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). {ECO:0000269|PubMed:20074521, ECO:0000269|PubMed:28483977, ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| Q13885 | TUBB2A | S115 | ochoa | Tubulin beta-2A chain (Tubulin beta class IIa) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q14008 | CKAP5 | S1861 | ochoa | Cytoskeleton-associated protein 5 (Colonic and hepatic tumor overexpressed gene protein) (Ch-TOG) | Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as a processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments (PubMed:27156448). {ECO:0000269|PubMed:12569123, ECO:0000269|PubMed:18809577, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:21646404, ECO:0000269|PubMed:23532825, ECO:0000269|PubMed:27156448, ECO:0000269|PubMed:9570755}. |
| Q14258 | TRIM25 | S340 | ochoa | E3 ubiquitin/ISG15 ligase TRIM25 (EC 6.3.2.n3) (Estrogen-responsive finger protein) (RING finger protein 147) (RING-type E3 ubiquitin transferase) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM25) (Tripartite motif-containing protein 25) (Ubiquitin/ISG15-conjugating enzyme TRIM25) (Zinc finger protein 147) | Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase (PubMed:16352599). Involved in innate immune defense against viruses by mediating ubiquitination of RIGI and IFIH1 (PubMed:17392790, PubMed:29357390, PubMed:30193849, PubMed:31710640, PubMed:33849980, PubMed:36045682). Mediates 'Lys-63'-linked polyubiquitination of the RIGI N-terminal CARD-like region and may play a role in signal transduction that leads to the production of interferons in response to viral infection (PubMed:17392790, PubMed:23950712). Mediates 'Lys-63'-linked polyubiquitination of IFIH1 (PubMed:30193849). Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway (PubMed:16352599, PubMed:17069755). Mediates estrogen action in various target organs (PubMed:22452784). Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3 (PubMed:22452784). Plays a role in promoting the restart of stalled replication forks via interaction with the KHDC3L-OOEP scaffold and subsequent ubiquitination of BLM, resulting in the recruitment and retainment of BLM at DNA replication forks (By similarity). Plays an essential role in the antiviral activity of ZAP/ZC3HAV1; an antiviral protein which inhibits the replication of certain viruses. Mechanistically, mediates 'Lys-63'-linked polyubiquitination of ZAP/ZC3HAV1 that is required for its optimal binding to target mRNA (PubMed:28060952, PubMed:28202764). Also mediates the ubiquitination of various substrates implicated in stress granule formation, nonsense-mediated mRNA decay, nucleoside synthesis and mRNA translation and stability (PubMed:36067236). {ECO:0000250|UniProtKB:Q61510, ECO:0000269|PubMed:16352599, ECO:0000269|PubMed:17069755, ECO:0000269|PubMed:17392790, ECO:0000269|PubMed:22452784, ECO:0000269|PubMed:23950712, ECO:0000269|PubMed:29357390, ECO:0000269|PubMed:30193849, ECO:0000269|PubMed:31710640, ECO:0000269|PubMed:33849980, ECO:0000269|PubMed:36045682, ECO:0000269|PubMed:36067236}. |
| Q14517 | FAT1 | S4473 | ochoa | Protocadherin Fat 1 (Cadherin family member 7) (Cadherin-related tumor suppressor homolog) (Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form] | [Protocadherin Fat 1]: Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact. {ECO:0000250}. |
| Q14669 | TRIP12 | S1250 | ochoa | E3 ubiquitin-protein ligase TRIP12 (EC 2.3.2.26) (E3 ubiquitin-protein ligase for Arf) (ULF) (HECT-type E3 ubiquitin transferase TRIP12) (Thyroid receptor-interacting protein 12) (TR-interacting protein 12) (TRIP-12) | E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair (PubMed:19028681, PubMed:22884692). Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins (PubMed:19028681). Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress (PubMed:20208519). In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation (PubMed:20208519). Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A (PubMed:20208519). Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation (PubMed:18627766). Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins (PubMed:20829358). Mediates ubiquitination of ASXL1: following binding to N(6)-methyladenosine methylated DNA, ASXL1 is ubiquitinated by TRIP12, leading to its degradation and subsequent inactivation of the PR-DUB complex (PubMed:30982744). {ECO:0000269|PubMed:18627766, ECO:0000269|PubMed:19028681, ECO:0000269|PubMed:20208519, ECO:0000269|PubMed:20829358, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:30982744}. |
| Q15759 | MAPK11 | S143 | psp | Mitogen-activated protein kinase 11 (MAP kinase 11) (MAPK 11) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (Stress-activated protein kinase 2b) (SAPK2b) (p38-2) | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway (PubMed:12452429, PubMed:20626350, PubMed:35857590). MAPK11 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors (PubMed:12452429, PubMed:20626350, PubMed:35857590). Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each (PubMed:12452429, PubMed:20626350, PubMed:35857590). MAPK11 functions are mostly redundant with those of MAPK14 (PubMed:12452429, PubMed:20626350, PubMed:35857590). Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets (PubMed:12452429, PubMed:20626350). RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1 (PubMed:9687510). RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery. On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2 (PubMed:11154262). In the cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17. Such phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR signaling and cell proliferation. Additional examples of p38 MAPK substrates are the FGFR1. FGFR1 can be translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A (PubMed:10330143, PubMed:15356147, PubMed:9430721). The p38 MAPKs are emerging as important modulators of gene expression by regulating chromatin modifiers and remodelers (PubMed:10330143, PubMed:15356147, PubMed:9430721). The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on 'Ser-10' (H3S10ph) in LPS-stimulated myeloid cells. This phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for increased NF-kappa-B recruitment. Phosphorylates NLRP1 downstream of MAP3K20/ZAK in response to UV-B irradiation and ribosome collisions, promoting activation of the NLRP1 inflammasome and pyroptosis (PubMed:35857590). Phosphorylates methyltransferase DOT1L on 'Ser-834', 'Thr-900', 'Ser-902', 'Thr-984', 'Ser-1001', 'Ser-1009' and 'Ser-1104' (PubMed:38270553). {ECO:0000269|PubMed:10330143, ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:15356147, ECO:0000269|PubMed:35857590, ECO:0000269|PubMed:38270553, ECO:0000269|PubMed:9430721, ECO:0000269|PubMed:9687510, ECO:0000303|PubMed:12452429, ECO:0000303|PubMed:20626350}. |
| Q17RH5 | RAPGEF2 | S794 | psp | Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (Neural RAP guanine nucleotide exchange protein) (PDZ domain-containing guanine nucleotide exchange factor 1) (RA-GEF-1) (Ras/Rap1-associating GEF-1) | None |
| Q53HL2 | CDCA8 | S238 | psp | Borealin (Cell division cycle-associated protein 8) (Dasra-B) (hDasra-B) (Pluripotent embryonic stem cell-related gene 3 protein) | Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment. {ECO:0000269|PubMed:15249581, ECO:0000269|PubMed:15260989, ECO:0000269|PubMed:16571674, ECO:0000269|PubMed:18243099}. |
| Q53TQ3 | INO80D | S728 | ochoa | INO80 complex subunit D | Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. |
| Q5BJF6 | ODF2 | S129 | ochoa | Outer dense fiber protein 2 (Cenexin) (Outer dense fiber of sperm tails protein 2) | Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. May have a modulating influence on sperm motility. Functions as a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. Component of the centrosome matrix required for the localization of PLK1 and NIN to the centrosomes. Required for the formation and/or maintenance of normal CETN1 assembly. {ECO:0000269|PubMed:16966375}. |
| Q5T5P2 | KIAA1217 | S532 | ochoa | Sickle tail protein homolog | Required for normal development of intervertebral disks. {ECO:0000250|UniProtKB:A2AQ25}. |
| Q5TCZ1 | SH3PXD2A | S379 | ochoa | SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains) | Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells (PubMed:27789576). Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. {ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:15710328, ECO:0000269|PubMed:15710903, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497, ECO:0000269|PubMed:27789576}. |
| Q5THJ4 | VPS13D | S926 | ochoa | Intermembrane lipid transfer protein VPS13D (Vacuolar protein sorting-associated protein 13D) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:29307555, ECO:0000269|PubMed:29604224}. |
| Q5VUA4 | ZNF318 | S1869 | ochoa | Zinc finger protein 318 (Endocrine regulatory protein) | [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}. |
| Q5VWQ8 | DAB2IP | S1140 | ochoa | Disabled homolog 2-interacting protein (DAB2 interaction protein) (DAB2-interacting protein) (ASK-interacting protein 1) (AIP-1) (DOC-2/DAB-2 interactive protein) | Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Involved in several processes such as innate immune response, inflammation and cell growth inhibition, apoptosis, cell survival, angiogenesis, cell migration and maturation. Also plays a role in cell cycle checkpoint control; reduces G1 phase cyclin levels resulting in G0/G1 cell cycle arrest. Mediates signal transduction by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF), interferon (IFN) or lipopolysaccharide (LPS). Modulates the balance between phosphatidylinositol 3-kinase (PI3K)-AKT-mediated cell survival and apoptosis stimulated kinase (MAP3K5)-JNK signaling pathways; sequesters both AKT1 and MAP3K5 and counterbalances the activity of each kinase by modulating their phosphorylation status in response to pro-inflammatory stimuli. Acts as a regulator of the endoplasmic reticulum (ER) unfolded protein response (UPR) pathway; specifically involved in transduction of the ER stress-response to the JNK cascade through ERN1. Mediates TNF-alpha-induced apoptosis activation by facilitating dissociation of inhibitor 14-3-3 from MAP3K5; recruits the PP2A phosphatase complex which dephosphorylates MAP3K5 on 'Ser-966', leading to the dissociation of 13-3-3 proteins and activation of the MAP3K5-JNK signaling pathway in endothelial cells. Also mediates TNF/TRAF2-induced MAP3K5-JNK activation, while it inhibits CHUK-NF-kappa-B signaling. Acts a negative regulator in the IFN-gamma-mediated JAK-STAT signaling cascade by inhibiting smooth muscle cell (VSMCs) proliferation and intimal expansion, and thus, prevents graft arteriosclerosis (GA). Acts as a GTPase-activating protein (GAP) for the ADP ribosylation factor 6 (ARF6), Ras and RAB40C (PubMed:29156729). Promotes hydrolysis of the ARF6-bound GTP and thus, negatively regulates phosphatidylinositol 4,5-bisphosphate (PIP2)-dependent TLR4-TIRAP-MyD88 and NF-kappa-B signaling pathways in endothelial cells in response to lipopolysaccharides (LPS). Binds specifically to phosphatidylinositol 4-phosphate (PtdIns4P) and phosphatidylinositol 3-phosphate (PtdIns3P). In response to vascular endothelial growth factor (VEGFA), acts as a negative regulator of the VEGFR2-PI3K-mediated angiogenic signaling pathway by inhibiting endothelial cell migration and tube formation. In the developing brain, promotes both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex in a glial-dependent locomotion process. Probable downstream effector of the Reelin signaling pathway; promotes Purkinje cell (PC) dendrites development and formation of cerebellar synapses. Also functions as a tumor suppressor protein in prostate cancer progression; prevents cell proliferation and epithelial-to-mesenchymal transition (EMT) through activation of the glycogen synthase kinase-3 beta (GSK3B)-induced beta-catenin and inhibition of PI3K-AKT and Ras-MAPK survival downstream signaling cascades, respectively. {ECO:0000269|PubMed:12813029, ECO:0000269|PubMed:17389591, ECO:0000269|PubMed:18292600, ECO:0000269|PubMed:19033661, ECO:0000269|PubMed:19903888, ECO:0000269|PubMed:19948740, ECO:0000269|PubMed:20080667, ECO:0000269|PubMed:20154697, ECO:0000269|PubMed:21700930, ECO:0000269|PubMed:22696229, ECO:0000269|PubMed:29156729}. |
| Q6ICG6 | KIAA0930 | S362 | ochoa | Uncharacterized protein KIAA0930 | None |
| Q6P0Q8 | MAST2 | S148 | ochoa | Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1) | Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}. |
| Q6P1N0 | CC2D1A | S292 | ochoa | Coiled-coil and C2 domain-containing protein 1A (Akt kinase-interacting protein 1) (Five prime repressor element under dual repression-binding protein 1) (FRE under dual repression-binding protein 1) (Freud-1) (Putative NF-kappa-B-activating protein 023N) | Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses (By similarity). Plays distinct roles depending on its localization. When cytoplasmic, acts as a scaffold protein in the PI3K/PDK1/AKT pathway. Repressor of HTR1A when nuclear. In the centrosome, regulates spindle pole localization of the cohesin subunit SCC1/RAD21, thereby mediating centriole cohesion during mitosis. {ECO:0000250, ECO:0000269|PubMed:20171170}. |
| Q6ZU80 | CEP128 | S1043 | ochoa | Centrosomal protein of 128 kDa (Cep128) | None |
| Q70EL1 | USP54 | S1250 | ochoa | Ubiquitin carboxyl-terminal hydrolase 54 (EC 3.4.19.12) (Ubiquitin-specific peptidase 54) | Deubiquitinase that specifically mediates 'Lys-63'-linked deubiquitination of substrates with a polyubiquitin chain composed of at least 3 ubiquitins (PubMed:39587316). Specifically recognizes ubiquitin chain in position S2 and catalyzes cleavage of polyubiquitin within 'Lys-63'-linked chains (PubMed:39587316). Not able to deubiquitinate substrates with shorter ubiquitin chains (PubMed:39587316). Mediates deubiquitination of PLK4, maintaining PLK4 stability by reducing its ubiquitination-mediated degradation (PubMed:36590171). {ECO:0000269|PubMed:36590171, ECO:0000269|PubMed:39587316}. |
| Q7Z2D5 | PLPPR4 | S346 | ochoa | Phospholipid phosphatase-related protein type 4 (Brain-specific phosphatidic acid phosphatase-like protein 1) (Inactive 2-lysophosphatidate phosphatase PLPPR4) (Lipid phosphate phosphatase-related protein type 4) (Plasticity-related gene 1 protein) (PRG-1) | Postsynaptic density membrane protein that indirectly regulates glutamatergic synaptic transmission through lysophosphatidic acid (LPA)-mediated signaling pathways. Binds lysophosphatidic acid (LPA) and mediates its internalization into cells. Could act as receptor or a transporter of this lipid at the post-synaptic membrane (By similarity). Modulates lysophosphatidic acid (LPA) activity in neuron axonal outgrowth during development by attenuating phospholipid-induced axon collapse (By similarity). {ECO:0000250|UniProtKB:Q7TMB7, ECO:0000250|UniProtKB:Q7TME0}. |
| Q7Z401 | DENND4A | S1606 | ochoa | C-myc promoter-binding protein (DENN domain-containing protein 4A) | Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter. {ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:8056341}. |
| Q7Z406 | MYH14 | S677 | ochoa | Myosin-14 (Myosin heavy chain 14) (Myosin heavy chain, non-muscle IIc) (Non-muscle myosin heavy chain IIc) (NMHC II-C) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. {ECO:0000250}. |
| Q86UW2 | SLC51B | S88 | ochoa | Organic solute transporter subunit beta (OST-beta) (Solute carrier family 51 subunit beta) | Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood (PubMed:16317684). Modulates SLC51A glycosylation, membrane trafficking and stability activities (PubMed:16317684). The Ost-alpha/Ost-beta complex efficiently transports the major species of bile acids (taurocholate) (PubMed:16317684). Taurine conjugates are transported more efficiently across the basolateral membrane than glycine-conjugated bile acids (By similarity). Can also transport steroids such as estrone 3-sulfate and dehydroepiandrosterone 3-sulfate, therefore playing a role in the enterohepatic circulation of sterols (PubMed:16317684). Able to transport eicosanoids such as prostaglandin E2 (By similarity). {ECO:0000250|UniProtKB:Q8R000, ECO:0000250|UniProtKB:Q90YM5, ECO:0000269|PubMed:16317684}. |
| Q86X27 | RALGPS2 | S26 | ochoa | Ras-specific guanine nucleotide-releasing factor RalGPS2 (Ral GEF with PH domain and SH3-binding motif 2) (RalA exchange factor RalGPS2) | Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeletal organization. May also be involved in the stimulation of transcription in a Ras-independent fashion (By similarity). {ECO:0000250}. |
| Q8IV36 | HID1 | S633 | ochoa | Protein HID1 (Down-regulated in multiple cancers 1) (HID1 domain-containing protein) (Protein hid-1 homolog) | May play an important role in the development of cancers in a broad range of tissues. {ECO:0000269|PubMed:11281419}. |
| Q8IVF2 | AHNAK2 | S1198 | ochoa | Protein AHNAK2 | None |
| Q8IXI1 | RHOT2 | S196 | ochoa | Mitochondrial Rho GTPase 2 (MIRO-2) (hMiro-2) (EC 3.6.5.-) (Ras homolog gene family member T2) | Atypical mitochondrial nucleoside-triphosphatase (NTPase) involved in mitochondrial trafficking (PubMed:16630562, PubMed:22396657, PubMed:30513825). Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (PubMed:22396657). Can hydrolyze GTP (By similarity). Can hydrolyze ATP and UTP (PubMed:30513825). {ECO:0000250|UniProtKB:Q8IXI2, ECO:0000269|PubMed:16630562, ECO:0000269|PubMed:22396657, ECO:0000269|PubMed:30513825}. |
| Q8N163 | CCAR2 | S687 | ochoa | Cell cycle and apoptosis regulator protein 2 (Cell division cycle and apoptosis regulator protein 2) (DBIRD complex subunit KIAA1967) (Deleted in breast cancer gene 1 protein) (DBC-1) (DBC.1) (NET35) (p30 DBC) | Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions (PubMed:22446626). Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis (PubMed:18235501, PubMed:18235502, PubMed:23352644). Inhibits SUV39H1 methyltransferase activity (PubMed:19218236). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress (PubMed:23398316). Regulates the circadian expression of the core clock components NR1D1 and BMAL1 (PubMed:23398316). Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation (PubMed:23398316). Represses the ligand-dependent transcriptional activation function of ESR2 (PubMed:20074560). Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 (PubMed:24415752). Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization (PubMed:21030595). Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway (PubMed:24824780). Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (PubMed:25661920). Plays an important role in tumor suppression through p53/TP53 regulation; stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 (PubMed:25732823). Represses the transcriptional activator activity of BRCA1 (PubMed:20160719). Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro (PubMed:25361978). {ECO:0000269|PubMed:18235501, ECO:0000269|PubMed:18235502, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19218236, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:22446626, ECO:0000269|PubMed:23352644, ECO:0000269|PubMed:23398316, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25661920, ECO:0000269|PubMed:25732823}. |
| Q8N1G4 | LRRC47 | S431 | ochoa | Leucine-rich repeat-containing protein 47 | None |
| Q8N302 | AGGF1 | S135 | ochoa | Angiogenic factor with G patch and FHA domains 1 (Angiogenic factor VG5Q) (hVG5Q) (G patch domain-containing protein 7) (Vasculogenesis gene on 5q protein) | Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion. {ECO:0000269|PubMed:14961121}. |
| Q8TBF2 | PRXL2B | S110 | ochoa | Prostamide/prostaglandin F synthase (Prostamide/PG F synthase) (Prostamide/PGF synthase) (EC 1.11.1.20) (Peroxiredoxin-like 2B) (Protein FAM213B) | Catalyzes the reduction of prostaglandin-ethanolamide H(2) (prostamide H(2)) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostaglandin H(2) to prostaglandin F(2alpha) (By similarity). {ECO:0000250|UniProtKB:Q9DB60}. |
| Q8TD26 | CHD6 | S1840 | ochoa | Chromodomain-helicase-DNA-binding protein 6 (CHD-6) (EC 3.6.4.-) (ATP-dependent helicase CHD6) (Radiation-induced gene B protein) | ATP-dependent chromatin-remodeling factor (PubMed:17027977, PubMed:28533432). Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin; nucleosome disruption requires ATP (PubMed:28533432). Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2. {ECO:0000269|PubMed:16314513, ECO:0000269|PubMed:17027977, ECO:0000269|PubMed:28533432}.; FUNCTION: (Microbial infection) Acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. {ECO:0000269|PubMed:20631145, ECO:0000269|PubMed:21899694, ECO:0000269|PubMed:23408615}. |
| Q8TEQ6 | GEMIN5 | S847 | ochoa | Gem-associated protein 5 (Gemin5) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:16857593, PubMed:18984161, PubMed:20513430, PubMed:33963192). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:18984161). To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate (PubMed:18984161). Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. Within the SMN complex, GEMIN5 recognizes and delivers the small nuclear RNAs (snRNAs) to the SMN complex (PubMed:11714716, PubMed:16314521, PubMed:16857593, PubMed:19377484, PubMed:19750007, PubMed:20513430, PubMed:27834343, PubMed:27881600, PubMed:27881601). Binds to the 7-methylguanosine cap of RNA molecules (PubMed:19750007, PubMed:27834343, PubMed:27881600, PubMed:27881601, Ref.27). Binds to the 3'-UTR of SMN1 mRNA and regulates its translation; does not affect mRNA stability (PubMed:25911097). May play a role in the regulation of protein synthesis via its interaction with ribosomes (PubMed:27507887). {ECO:0000269|PubMed:11714716, ECO:0000269|PubMed:16314521, ECO:0000269|PubMed:16857593, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:19377484, ECO:0000269|PubMed:19750007, ECO:0000269|PubMed:20513430, ECO:0000269|PubMed:25911097, ECO:0000269|PubMed:27507887, ECO:0000269|PubMed:27834343, ECO:0000269|PubMed:27881600, ECO:0000269|PubMed:27881601, ECO:0000269|PubMed:33963192, ECO:0000269|Ref.27}. |
| Q8TF40 | FNIP1 | S174 | ochoa | Folliculin-interacting protein 1 | Binding partner of the GTPase-activating protein FLCN: involved in the cellular response to amino acid availability by regulating the non-canonical mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3 (PubMed:17028174, PubMed:18663353, PubMed:24081491, PubMed:37079666). Required to promote FLCN recruitment to lysosomes and interaction with Rag GTPases, leading to activation of the non-canonical mTORC1 signaling (PubMed:24081491). In low-amino acid conditions, component of the lysosomal folliculin complex (LFC) on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, thereby inactivating mTORC1 and promoting nuclear translocation of TFEB and TFE3 (By similarity). Upon amino acid restimulation, disassembly of the LFC complex liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent inactivation of TFEB and TFE3 (PubMed:37079666). Together with FLCN, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy (PubMed:25126726). In addition to its role in mTORC1 signaling, also acts as a co-chaperone of HSP90AA1/Hsp90: following gradual phosphorylation by CK2, inhibits the ATPase activity of HSP90AA1/Hsp90, leading to activate both kinase and non-kinase client proteins of HSP90AA1/Hsp90 (PubMed:27353360, PubMed:30699359). Acts as a scaffold to load client protein FLCN onto HSP90AA1/Hsp90 (PubMed:27353360). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360). Also acts as a core component of the reductive stress response by inhibiting activation of mitochondria in normal conditions: in response to reductive stress, the conserved Cys degron is reduced, leading to recognition and polyubiquitylation by the CRL2(FEM1B) complex, followed by proteasomal (By similarity). Required for B-cell development (PubMed:32905580). {ECO:0000250|UniProtKB:Q68FD7, ECO:0000250|UniProtKB:Q9P278, ECO:0000269|PubMed:17028174, ECO:0000269|PubMed:18663353, ECO:0000269|PubMed:24081491, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:30699359, ECO:0000269|PubMed:32905580, ECO:0000269|PubMed:37079666}. |
| Q8TF76 | HASPIN | S108 | ochoa|psp | Serine/threonine-protein kinase haspin (EC 2.7.11.1) (Germ cell-specific gene 2 protein) (H-haspin) (Haploid germ cell-specific nuclear protein kinase) | Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle. {ECO:0000269|PubMed:11228240, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:17084365, ECO:0000269|PubMed:20705812, ECO:0000269|PubMed:20929775}. |
| Q8WXI2 | CNKSR2 | S908 | ochoa | Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR 2) (CNK homolog protein 2) (CNK2) | May function as an adapter protein or regulator of Ras signaling pathways. {ECO:0000269|PubMed:14597674}. |
| Q92609 | TBC1D5 | S460 | ochoa | TBC1 domain family member 5 | May act as a GTPase-activating protein (GAP) for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol; at least retromer displacement seems to require its catalytic activity (PubMed:19531583, PubMed:20923837). Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN); the function seems to require its catalytic activity. Involved in regulation of autophagy (PubMed:22354992). May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogramming vesicle trafficking upon autophagy induction. Involved in the trafficking of ATG9A upon activation of autophagy. May regulate the recruitment of ATG9A-AP2-containing vesicles to autophagic membranes (PubMed:24603492). {ECO:0000269|PubMed:19531583, ECO:0000269|PubMed:20923837, ECO:0000269|PubMed:22354992, ECO:0000269|PubMed:24603492, ECO:0000305|PubMed:19531583, ECO:0000305|PubMed:22354992, ECO:0000305|PubMed:24603492}. |
| Q92985 | IRF7 | S472 | psp | Interferon regulatory factor 7 (IRF-7) | Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses (PubMed:28342865, PubMed:28768858). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:17574024, PubMed:32972995). Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Induces transcription of ubiquitin hydrolase USP25 mRNA in response to lipopolysaccharide (LPS) or viral infection in a type I IFN-dependent manner (By similarity). Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages (By similarity) (PubMed:11073981, PubMed:12374802, PubMed:15361868, PubMed:17404045). {ECO:0000250|UniProtKB:P70434, ECO:0000269|PubMed:11073981, ECO:0000269|PubMed:12374802, ECO:0000269|PubMed:15361868, ECO:0000269|PubMed:17404045, ECO:0000269|PubMed:17574024, ECO:0000269|PubMed:28342865, ECO:0000269|PubMed:28768858, ECO:0000269|PubMed:32972995}. |
| Q96A72 | MAGOHB | S108 | ochoa | Protein mago nashi homolog 2 | Required for pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:29301961, PubMed:30705154). Plays a redundant role with MAGOH in the exon junction complex and in the nonsense-mediated decay (NMD) pathway (PubMed:23917022). {ECO:0000269|PubMed:23917022, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:30705154}. |
| Q96AA8 | JAKMIP2 | S376 | ochoa | Janus kinase and microtubule-interacting protein 2 (CTCL tumor antigen HD-CL-04) (Neuroendocrine long coiled-coil protein 1) | None |
| Q96HA1 | POM121 | S543 | ochoa | Nuclear envelope pore membrane protein POM 121 (Nuclear envelope pore membrane protein POM 121A) (Nucleoporin Nup121) (Pore membrane protein of 121 kDa) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| Q96I34 | PPP1R16A | S60 | ochoa | Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase-targeting subunit 3) | Inhibits protein phosphatase 1 activity toward phosphorylase, myosin light chain and myosin substrates. {ECO:0000250}. |
| Q96KQ7 | EHMT2 | S232 | ochoa | Histone-lysine N-methyltransferase EHMT2 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Lysine N-methyltransferase 1C) (Protein G9a) | Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself. {ECO:0000250|UniProtKB:Q9Z148, ECO:0000269|PubMed:11316813, ECO:0000269|PubMed:18438403, ECO:0000269|PubMed:20084102, ECO:0000269|PubMed:20118233, ECO:0000269|PubMed:22387026, ECO:0000269|PubMed:8457211}. |
| Q96L93 | KIF16B | S1172 | ochoa | Kinesin-like protein KIF16B (Sorting nexin-23) | Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. {ECO:0000269|PubMed:15882625}. |
| Q96P11 | NSUN5 | S167 | ochoa | 28S rRNA (cytosine-C(5))-methyltransferase (EC 2.1.1.-) (NOL1-related protein) (NOL1R) (NOL1/NOP2/Sun domain family member 5) (Williams-Beuren syndrome chromosomal region 20A protein) | S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 3782 (m5C3782) in 28S rRNA (PubMed:23913415, PubMed:31428936, PubMed:31722427). m5C3782 promotes protein translation without affecting ribosome biogenesis and fidelity (PubMed:31428936, PubMed:31722427). Required for corpus callosum and cerebral cortex development (By similarity). {ECO:0000250|UniProtKB:Q8K4F6, ECO:0000269|PubMed:23913415, ECO:0000269|PubMed:31428936, ECO:0000269|PubMed:31722427}. |
| Q99698 | LYST | S2124 | ochoa | Lysosomal-trafficking regulator (Beige homolog) | Adapter protein that regulates and/or fission of intracellular vesicles such as lysosomes (PubMed:11984006, PubMed:25216107). Might regulate trafficking of effectors involved in exocytosis (PubMed:25425525). In cytotoxic T-cells and natural killer (NK) cells, has role in the regulation of size, number and exocytosis of lytic granules (PubMed:26478006). In macrophages and dendritic cells, regulates phagosome maturation by controlling the conversion of early phagosomal compartments into late phagosomes (By similarity). In macrophages and dendritic cells, specifically involved in TLR3- and TLR4-induced production of pro-inflammatory cytokines by regulating the endosomal TLR3- TICAM1/TRIF and TLR4- TICAM1/TRIF signaling pathways (PubMed:27881733). {ECO:0000250|UniProtKB:P97412, ECO:0000269|PubMed:11984006, ECO:0000269|PubMed:25216107, ECO:0000269|PubMed:25425525, ECO:0000269|PubMed:26478006, ECO:0000269|PubMed:27881733}. |
| Q9BV23 | ABHD6 | S115 | ochoa | Monoacylglycerol lipase ABHD6 (EC 3.1.1.23) (2-arachidonoylglycerol hydrolase) (Abhydrolase domain-containing protein 6) | Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (PubMed:22969151). Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways (By similarity). Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity). Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism (PubMed:26491015). BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and plays a key role in the formation of intraluminal vesicles and in lipid sorting (PubMed:26491015). {ECO:0000250|UniProtKB:Q8R2Y0, ECO:0000269|PubMed:22969151, ECO:0000269|PubMed:26491015}. |
| Q9BVA1 | TUBB2B | S115 | ochoa | Tubulin beta-2B chain | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:23001566, PubMed:26732629, PubMed:28013290). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910). {ECO:0000269|PubMed:19465910, ECO:0000269|PubMed:23001566, ECO:0000269|PubMed:26732629, ECO:0000269|PubMed:28013290}. |
| Q9BWT3 | PAPOLG | S508 | ochoa | Poly(A) polymerase gamma (PAP-gamma) (EC 2.7.7.19) (Neo-poly(A) polymerase) (Neo-PAP) (Polynucleotide adenylyltransferase gamma) (SRP RNA 3'-adenylating enzyme) (Signal recognition particle RNA-adenylating enzyme) (SRP RNA-adenylating enzyme) | Responsible for the post-transcriptional adenylation of the 3'-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA. {ECO:0000269|PubMed:11287430, ECO:0000269|PubMed:11463842}. |
| Q9H081 | MIS12 | S180 | ochoa | Protein MIS12 homolog | Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis (PubMed:12515822, PubMed:15502821, PubMed:16585270). Essential for proper kinetochore microtubule attachments (PubMed:23891108). {ECO:0000269|PubMed:12515822, ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:16585270, ECO:0000269|PubMed:23891108}. |
| Q9H4G0 | EPB41L1 | S510 | ochoa | Band 4.1-like protein 1 (Erythrocyte membrane protein band 4.1-like 1) (Neuronal protein 4.1) (4.1N) | May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases. |
| Q9H5I5 | PIEZO2 | S838 | ochoa | Piezo-type mechanosensitive ion channel component 2 (Protein FAM38B) | Pore-forming subunit of the mechanosensitive non-specific cation Piezo channel required for rapidly adapting mechanically activated (MA) currents and has a key role in sensing touch and tactile pain (PubMed:37590348). Piezo channels are homotrimeric three-blade propeller-shaped structures that utilize a cap-motion and plug-and-latch mechanism to gate their ion-conducting pathways (PubMed:37590348). Expressed in sensory neurons, is essential for diverse physiological processes, including respiratory control, systemic metabolism, urinary function, and proprioception (By similarity). Mediates airway stretch sensing, enabling efficient respiration at birth and maintaining normal breathing in adults (By similarity). It regulates brown and beige adipose tissue morphology and function, preventing systemic hypermetabolism (By similarity). In the lower urinary tract, acts as a sensor in both the bladder urothelium and innervating sensory neurons being required for bladder-stretch sensing and urethral micturition reflexes, ensuring proper urinary function (PubMed:33057202). Additionally, PIEZO2 serves as the principal mechanotransducer in proprioceptors, facilitating proprioception and coordinated body movements (By similarity). In inner ear hair cells, PIEZO1/2 subunits may constitute part of the mechanotransducer (MET) non-selective cation channel complex where they may act as pore-forming ion-conducting component in the complex (By similarity). Required for Merkel-cell mechanotransduction (By similarity). Plays a major role in light-touch mechanosensation (By similarity). {ECO:0000250|UniProtKB:Q8CD54, ECO:0000269|PubMed:33057202, ECO:0000269|PubMed:37590348}. |
| Q9H6T3 | RPAP3 | S481 | ochoa | RNA polymerase II-associated protein 3 | Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. {ECO:0000269|PubMed:17643375}. |
| Q9H9C1 | VIPAS39 | S156 | ochoa | Spermatogenesis-defective protein 39 homolog (hSPE-39) (VPS33B-interacting protein in apical-basolateral polarity regulator) (VPS33B-interacting protein in polarity and apical restriction) | Proposed to be involved in endosomal maturation implicating in part VPS33B. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical RAB11A-dependent recycling pathway and in the maintenance of the apical-basolateral polarity (PubMed:20190753). May play a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes; the functions seems to be independent of VPS33B (PubMed:19109425). May play a role in vesicular trafficking during spermatogenesis (By similarity). May be involved in direct or indirect transcriptional regulation of E-cadherin (By similarity). {ECO:0000250|UniProtKB:Q23288, ECO:0000269|PubMed:19109425, ECO:0000269|PubMed:20190753}. |
| Q9HAC8 | UBTD1 | S166 | ochoa | Ubiquitin domain-containing protein 1 | May be involved in the regulation of cellular senescence through a positive feedback loop with TP53. Is a TP53 downstream target gene that increases the stability of TP53 protein by promoting the ubiquitination and degradation of MDM2. {ECO:0000269|PubMed:25382750}. |
| Q9HCS5 | EPB41L4A | S618 | ochoa | Band 4.1-like protein 4A (Erythrocyte membrane protein band 4.1-like 4A) (Protein NBL4) | None |
| Q9NPB6 | PARD6A | S109 | ochoa | Partitioning defective 6 homolog alpha (PAR-6) (PAR-6 alpha) (PAR-6A) (PAR6C) (Tax interaction protein 40) (TIP-40) | Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10873802). Regulates centrosome organization and function. Essential for the centrosomal recruitment of key proteins that control centrosomal microtubule organization (PubMed:20719959). {ECO:0000269|PubMed:10873802, ECO:0000269|PubMed:20719959}. |
| Q9NR09 | BIRC6 | S2222 | ochoa | Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 (EC 2.3.2.24) (BIR repeat-containing ubiquitin-conjugating enzyme) (BRUCE) (Baculoviral IAP repeat-containing protein 6) (Ubiquitin-conjugating BIR domain enzyme apollon) (APOLLON) | Anti-apoptotic protein known as inhibitor of apoptosis (IAP) which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase (PubMed:14765125, PubMed:15200957, PubMed:18329369). Unlike most IAPs, does not contain a RING domain and it is not a RING-type E3 ligase (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Instead acts as a dual E2/E3 enzyme that combines ubiquitin conjugating (E2) and ubiquitin ligase (E3) activities in a single polypeptide (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitination is mediated by a non-canonical E1 ubiquitin activating enzyme UBA6 (PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates CASP3, CASP7 and CASP9 and inhibits their caspase activity; also ubiquitinates their procaspases but to a weaker extent (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates pro-apoptotic factors DIABLO/SMAC and HTRA2 (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). DIABLO/SMAC antagonizes the caspase inhibition activity of BIRC6 by competing for the same binding sites as the caspases (PubMed:18329369, PubMed:36758106). Ubiquitinates the autophagy protein MAP1LC3B; this activity is also inhibited by DIABLO/SMAC (PubMed:36758105). Important regulator for the final stages of cytokinesis (PubMed:18329369). Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification (PubMed:18329369). {ECO:0000269|PubMed:14765125, ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:18329369, ECO:0000269|PubMed:36758104, ECO:0000269|PubMed:36758105, ECO:0000269|PubMed:36758106}. |
| Q9NRY4 | ARHGAP35 | S866 | psp | Rho GTPase-activating protein 35 (Glucocorticoid receptor DNA-binding factor 1) (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A) | Rho GTPase-activating protein (GAP) (PubMed:19673492, PubMed:28894085). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity (PubMed:19673492). This binding is inhibited by phosphorylation by PRKCA (PubMed:19673492). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP) (By similarity). Transduces SRC-dependent signals from cell-surface adhesion molecules, such as laminin, to promote neurite outgrowth. Regulates axon outgrowth, guidance and fasciculation (By similarity). Modulates Rho GTPase-dependent F-actin polymerization, organization and assembly, is involved in polarized cell migration and in the positive regulation of ciliogenesis and cilia elongation (By similarity). During mammary gland development, is required in both the epithelial and stromal compartments for ductal outgrowth (By similarity). Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'; this function is however unclear and would need additional experimental evidences (PubMed:1894621). {ECO:0000250|UniProtKB:P81128, ECO:0000250|UniProtKB:Q91YM2, ECO:0000269|PubMed:1894621, ECO:0000269|PubMed:19673492, ECO:0000269|PubMed:28894085}. |
| Q9NSA2 | KCND1 | S265 | psp | A-type voltage-gated potassium channel KCND1 (Potassium voltage-gated channel subfamily D member 1) (Shal-type potassium channel KCND1) (Voltage-gated potassium channel subunit Kv4.1) | A-type voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes in the brain (PubMed:15454437). Mediates A-type current I(SA) in suprachiasmatic nucleus (SCN) neurons. Exhibits a low-threshold A-type current with a hyperpolarized steady-state inactivation midpoint and the recovery process was steeply voltage-dependent, with recovery being markedly faster at more negative potentials. May regulates repetitive firing rates in the suprachiasmatic nucleus (SCN) neurons and circadian rhythms in neuronal excitability and behavior. Contributes to the regulation of the circadian rhythm of action potential firing in suprachiasmatic nucleus neurons, which regulates the circadian rhythm of locomotor activity. The regulatory subunit KCNIP1 modulates the kinetics of channel inactivation, increases the current amplitudes and accelerates recovery from inactivation, shifts activation in a depolarizing direction (By similarity). The regulatory subunit DPP10 decreases the voltage sensitivity of the inactivation channel gating (PubMed:15454437). {ECO:0000250|UniProtKB:Q03719, ECO:0000269|PubMed:15454437}. |
| Q9NZI8 | IGF2BP1 | S314 | ochoa | Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2 mRNA-binding protein 1) (IMP-1) (IMP1) (Coding region determinant-binding protein) (CRD-BP) (IGF-II mRNA-binding protein 1) (VICKZ family member 1) (Zipcode-binding protein 1) (ZBP-1) | RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (PubMed:29476152, PubMed:32245947). Plays a direct role in the transport and translation of transcripts required for axonal regeneration in adult sensory neurons (By similarity). Regulates localized beta-actin/ACTB mRNA translation, a crucial process for cell polarity, cell migration and neurite outgrowth. Co-transcriptionally associates with the ACTB mRNA in the nucleus. This binding involves a conserved 54-nucleotide element in the ACTB mRNA 3'-UTR, known as the 'zipcode'. The RNP thus formed is exported to the cytoplasm, binds to a motor protein and is transported along the cytoskeleton to the cell periphery. During transport, prevents ACTB mRNA from being translated into protein. When the RNP complex reaches its destination near the plasma membrane, IGF2BP1 is phosphorylated. This releases the mRNA, allowing ribosomal 40S and 60S subunits to assemble and initiate ACTB protein synthesis. Monomeric ACTB then assembles into the subcortical actin cytoskeleton (By similarity). During neuronal development, key regulator of neurite outgrowth, growth cone guidance and neuronal cell migration, presumably through the spatiotemporal fine tuning of protein synthesis, such as that of ACTB (By similarity). May regulate mRNA transport to activated synapses (By similarity). Binds to and stabilizes ABCB1/MDR-1 mRNA (By similarity). During interstinal wound repair, interacts with and stabilizes PTGS2 transcript. PTGS2 mRNA stabilization may be crucial for colonic mucosal wound healing (By similarity). Binds to the 3'-UTR of IGF2 mRNA by a mechanism of cooperative and sequential dimerization and regulates IGF2 mRNA subcellular localization and translation. Binds to MYC mRNA, in the coding region instability determinant (CRD) of the open reading frame (ORF), hence preventing MYC cleavage by endonucleases and possibly microRNA targeting to MYC-CRD (PubMed:29476152). Binding to MYC mRNA is enhanced by m6A-modification of the CRD (PubMed:29476152). Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to the oncofetal H19 transcript and to the neuron-specific TAU mRNA and regulates their localizations. Binds to and stabilizes BTRC/FBW1A mRNA. Binds to the adenine-rich autoregulatory sequence (ARS) located in PABPC1 mRNA and represses its translation. PABPC1 mRNA-binding is stimulated by PABPC1 protein. Prevents BTRC/FBW1A mRNA degradation by disrupting microRNA-dependent interaction with AGO2. Promotes the directed movement of tumor-derived cells by fine-tuning intracellular signaling networks. Binds to MAPK4 3'-UTR and inhibits its translation. Interacts with PTEN transcript open reading frame (ORF) and prevents mRNA decay. This combined action on MAPK4 (down-regulation) and PTEN (up-regulation) antagonizes HSPB1 phosphorylation, consequently it prevents G-actin sequestration by phosphorylated HSPB1, allowing F-actin polymerization. Hence enhances the velocity of cell migration and stimulates directed cell migration by PTEN-modulated polarization. Interacts with Hepatitis C virus (HCV) 5'-UTR and 3'-UTR and specifically enhances translation at the HCV IRES, but not 5'-cap-dependent translation, possibly by recruiting eIF3. Interacts with HIV-1 GAG protein and blocks the formation of infectious HIV-1 particles. Reduces HIV-1 assembly by inhibiting viral RNA packaging, as well as assembly and processing of GAG protein on cellular membranes. During cellular stress, such as oxidative stress or heat shock, stabilizes target mRNAs that are recruited to stress granules, including CD44, IGF2, MAPK4, MYC, PTEN, RAPGEF2 and RPS6KA5 transcripts. {ECO:0000250, ECO:0000269|PubMed:10875929, ECO:0000269|PubMed:16356927, ECO:0000269|PubMed:16541107, ECO:0000269|PubMed:16778892, ECO:0000269|PubMed:17101699, ECO:0000269|PubMed:17255263, ECO:0000269|PubMed:17893325, ECO:0000269|PubMed:18385235, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:19541769, ECO:0000269|PubMed:19647520, ECO:0000269|PubMed:20080952, ECO:0000269|PubMed:22279049, ECO:0000269|PubMed:29476152, ECO:0000269|PubMed:32245947, ECO:0000269|PubMed:8132663, ECO:0000269|PubMed:9891060}. |
| Q9UBY0 | SLC9A2 | S596 | ochoa | Sodium/hydrogen exchanger 2 (Na(+)/H(+) exchanger 2) (NHE-2) (Solute carrier family 9 member 2) | Plasma membrane Na(+)/H(+) antiporter. Mediates the electroneutral exchange of intracellular H(+) ions for extracellular Na(+) (PubMed:10444453). Major apical Na(+)/H(+) exchanger in the base of the colonic crypt. Controls in the colonic crypt intracellular pH (pHi) to direct colonic epithelial cell differentiation into the absorptive enterocyte lineage at the expense of the secretory lineage (By similarity). {ECO:0000250|UniProtKB:Q3ZAS0, ECO:0000269|PubMed:10444453}. |
| Q9UHP3 | USP25 | S745 | psp | Ubiquitin carboxyl-terminal hydrolase 25 (EC 3.4.19.12) (Deubiquitinating enzyme 25) (USP on chromosome 21) (Ubiquitin thioesterase 25) (Ubiquitin-specific-processing protease 25) | Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions in various biological processes including inflammation and immune response (PubMed:29518389, PubMed:37683630). Modulates the Wnt/beta-catenin pathway by deubiquitinating and stabilizing tankyrases TNKS1 and TNKS2 (PubMed:28619731, PubMed:30926243, PubMed:38875478). Regulates KEAP1-NRF2 axis in the defense against oxidative assaults by deubiquitinating KEAP1 and protecting it from degradation leading to degradation of the NRF2 transcription factor that is responsible for mounting an anti-oxidation gene expression program (PubMed:37339955). Positively regulates RNA virus-induced innate signaling by interacting with and deubiquitinating ERLIN1 and ERLIN2 (PubMed:37683630). In turn, restricts virus production by regulating cholesterol biosynthetic flux (PubMed:37683630). Acts as a negative regulator of interleukin-17-mediated signaling and inflammation through the removal of 'Lys-63'-linked ubiquitination of TRAF5 and TRAF6 (PubMed:23042150). Prevents the ubiquitination and degradation of TRAF3 to reduce the phosphorylation levels of JNK and P38, the secretion of IL-1B and to induce endotoxin tolerance (PubMed:30579117). {ECO:0000269|PubMed:23042150, ECO:0000269|PubMed:28619731, ECO:0000269|PubMed:29518389, ECO:0000269|PubMed:30579117, ECO:0000269|PubMed:30926243, ECO:0000269|PubMed:37339955, ECO:0000269|PubMed:37683630, ECO:0000269|PubMed:38875478}.; FUNCTION: The muscle-specific isoform (USP25m) may have a role in the regulation of muscular differentiation and function. |
| Q9UKX2 | MYH2 | S648 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9ULD2 | MTUS1 | S774 | ochoa | Microtubule-associated tumor suppressor 1 (AT2 receptor-binding protein) (Angiotensin-II type 2 receptor-interacting protein) (Mitochondrial tumor suppressor 1) | Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. {ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:19794912}. |
| Q9UM54 | MYO6 | S266 | ochoa | Unconventional myosin-VI (Unconventional myosin-6) | Myosins are actin-based motor molecules with ATPase activity (By similarity). Unconventional myosins serve in intracellular movements (By similarity). Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments (PubMed:10519557). Has slow rate of actin-activated ADP release due to weak ATP binding (By similarity). Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration (By similarity). Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway (PubMed:16507995). Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells (PubMed:11447109). Together with TOM1, mediates delivery of endocytic cargo to autophagosomes thereby promoting autophagosome maturation and driving fusion with lysosomes (PubMed:23023224). Links TOM1 with autophagy receptors, such as TAX1BP1; CALCOCO2/NDP52 and OPTN (PubMed:31371777). May act as a regulator of F-actin dynamics (By similarity). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). May play a role in transporting DAB2 from the plasma membrane to specific cellular targets (By similarity). May play a role in the extension and network organization of neurites (By similarity). Required for structural integrity of inner ear hair cells (By similarity). Required for the correct localization of CLIC5 and RDX at the stereocilium base (By similarity). Modulates RNA polymerase II-dependent transcription (PubMed:16949370). {ECO:0000250|UniProtKB:Q29122, ECO:0000250|UniProtKB:Q64331, ECO:0000269|PubMed:10519557, ECO:0000269|PubMed:11447109, ECO:0000269|PubMed:16507995, ECO:0000269|PubMed:16949370, ECO:0000269|PubMed:23023224, ECO:0000269|PubMed:29467281, ECO:0000269|PubMed:31371777}. |
| Q9UNZ2 | NSFL1C | S176 | ochoa|psp | NSFL1 cofactor p47 (UBX domain-containing protein 2C) (p97 cofactor p47) | Reduces the ATPase activity of VCP (By similarity). Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro) (PubMed:15498563). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807). Also, regulates spindle orientation during mitosis (PubMed:23649807). {ECO:0000250|UniProtKB:O35987, ECO:0000269|PubMed:15498563, ECO:0000269|PubMed:23649807}. |
| Q9UPN3 | MACF1 | S820 | ochoa | Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) | [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250|UniProtKB:Q9QXZ0, ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:27693509}. |
| Q9UQC2 | GAB2 | S264 | ochoa | GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100) | Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. {ECO:0000269|PubMed:15750601, ECO:0000269|PubMed:19172738}. |
| Q9UQR0 | SCML2 | S547 | ochoa | Sex comb on midleg-like protein 2 | Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity). {ECO:0000250}. |
| Q9Y2X7 | GIT1 | S449 | psp | ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) (p95-APP1) | GTPase-activating protein for ADP ribosylation factor family members, including ARF1. Multidomain scaffold protein that interacts with numerous proteins and therefore participates in many cellular functions, including receptor internalization, focal adhesion remodeling, and signaling by both G protein-coupled receptors and tyrosine kinase receptors (By similarity). Through PAK1 activation, positively regulates microtubule nucleation during interphase (PubMed:27012601). Plays a role in the regulation of cytokinesis; for this function, may act in a pathway also involving ENTR1 and PTPN13 (PubMed:23108400). May promote cell motility both by regulating focal complex dynamics and by local activation of RAC1 (PubMed:10938112, PubMed:11896197). May act as scaffold for MAPK1/3 signal transduction in focal adhesions. Recruits MAPK1/3/ERK1/2 to focal adhesions after EGF stimulation via a Src-dependent pathway, hence stimulating cell migration (PubMed:15923189). Plays a role in brain development and function. Involved in the regulation of spine density and synaptic plasticity that is required for processes involved in learning (By similarity). Plays an important role in dendritic spine morphogenesis and synapse formation (PubMed:12695502, PubMed:15800193). In hippocampal neurons, recruits guanine nucleotide exchange factors (GEFs), such as ARHGEF7/beta-PIX, to the synaptic membrane. These in turn locally activate RAC1, which is an essential step for spine morphogenesis and synapse formation (PubMed:12695502). May contribute to the organization of presynaptic active zones through oligomerization and formation of a Piccolo/PCLO-based protein network, which includes ARHGEF7/beta-PIX and FAK1 (By similarity). In neurons, through its interaction with liprin-alpha family members, may be required for AMPA receptor (GRIA2/3) proper targeting to the cell membrane (By similarity). In complex with GABA(A) receptors and ARHGEF7, plays a crucial role in regulating GABA(A) receptor synaptic stability, maintaining GPHN/gephyrin scaffolds and hence GABAergic inhibitory synaptic transmission, by locally coordinating RAC1 and PAK1 downstream effector activity, leading to F-actin stabilization (PubMed:25284783). May also be important for RAC1 downstream signaling pathway through PAK3 and regulation of neuronal inhibitory transmission at presynaptic input (By similarity). Required for successful bone regeneration during fracture healing (By similarity). The function in intramembranous ossification may, at least partly, exerted by macrophages in which GIT1 is a key negative regulator of redox homeostasis, IL1B production, and glycolysis, acting through the ERK1/2/NRF2/NFE2L2 axis (By similarity). May play a role in angiogenesis during fracture healing (By similarity). In this process, may regulate activation of the canonical NF-kappa-B signal in bone mesenchymal stem cells by enhancing the interaction between NEMO and 'Lys-63'-ubiquitinated RIPK1/RIP1, eventually leading to enhanced production of VEGFA and others angiogenic factors (PubMed:31502302). Essential for VEGF signaling through the activation of phospholipase C-gamma and ERK1/2, hence may control endothelial cell proliferation and angiogenesis (PubMed:19273721). {ECO:0000250|UniProtKB:Q68FF6, ECO:0000250|UniProtKB:Q9Z272, ECO:0000269|PubMed:10938112, ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:12695502, ECO:0000269|PubMed:15800193, ECO:0000269|PubMed:15923189, ECO:0000269|PubMed:19273721, ECO:0000269|PubMed:23108400, ECO:0000269|PubMed:25284783, ECO:0000269|PubMed:27012601, ECO:0000269|PubMed:31502302}. |
| Q9Y3P9 | RABGAP1 | S56 | ochoa | Rab GTPase-activating protein 1 (GAP and centrosome-associated protein) (Rab6 GTPase-activating protein GAPCenA) | May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by centrosome. May participate in a RAB6A-mediated pathway involved in the metaphase-anaphase transition. {ECO:0000269|PubMed:10202141, ECO:0000269|PubMed:16395330}. |
| Q9Y3Z3 | SAMHD1 | S92 | ochoa | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) (EC 3.1.5.-) (Dendritic cell-derived IFNG-induced protein) (DCIP) (Monocyte protein 5) (MOP-5) (SAM domain and HD domain-containing protein 1) (hSAMHD1) | Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks (PubMed:19525956, PubMed:21613998, PubMed:21720370, PubMed:22056990, PubMed:23601106, PubMed:23602554, PubMed:24336198, PubMed:26294762, PubMed:26431200, PubMed:28229507, PubMed:28834754, PubMed:29670289). Has deoxynucleoside triphosphate (dNTPase) activity, which is required to restrict infection by viruses, such as HIV-1: dNTPase activity reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur, blocking early-stage virus replication in dendritic and other myeloid cells (PubMed:19525956, PubMed:21613998, PubMed:21720370, PubMed:22056990, PubMed:23364794, PubMed:23601106, PubMed:23602554, PubMed:24336198, PubMed:25038827, PubMed:26101257, PubMed:26294762, PubMed:26431200, PubMed:28229507). Likewise, suppresses LINE-1 retrotransposon activity (PubMed:24035396, PubMed:24217394, PubMed:29610582). Not able to restrict infection by HIV-2 virus; because restriction activity is counteracted by HIV-2 viral protein Vpx (PubMed:21613998, PubMed:21720370). In addition to virus restriction, dNTPase activity acts as a regulator of DNA precursor pools by regulating dNTP pools (PubMed:23858451). Phosphorylation at Thr-592 acts as a switch to control dNTPase-dependent and -independent functions: it inhibits dNTPase activity and ability to restrict infection by viruses, while it promotes DNA end resection at stalled replication forks (PubMed:23601106, PubMed:23602554, PubMed:29610582, PubMed:29670289). Functions during S phase at stalled DNA replication forks to promote the resection of gapped or reversed forks: acts by stimulating the exonuclease activity of MRE11, activating the ATR-CHK1 pathway and allowing the forks to restart replication (PubMed:29670289). Its ability to promote degradation of nascent DNA at stalled replication forks is required to prevent induction of type I interferons, thereby preventing chronic inflammation (PubMed:27477283, PubMed:29670289). Ability to promote DNA end resection at stalled replication forks is independent of dNTPase activity (PubMed:29670289). Enhances immunoglobulin hypermutation in B-lymphocytes by promoting transversion mutation (By similarity). {ECO:0000250|UniProtKB:Q60710, ECO:0000269|PubMed:19525956, ECO:0000269|PubMed:21613998, ECO:0000269|PubMed:21720370, ECO:0000269|PubMed:22056990, ECO:0000269|PubMed:23364794, ECO:0000269|PubMed:23601106, ECO:0000269|PubMed:23602554, ECO:0000269|PubMed:23858451, ECO:0000269|PubMed:24035396, ECO:0000269|PubMed:24217394, ECO:0000269|PubMed:24336198, ECO:0000269|PubMed:25038827, ECO:0000269|PubMed:26101257, ECO:0000269|PubMed:26294762, ECO:0000269|PubMed:26431200, ECO:0000269|PubMed:27477283, ECO:0000269|PubMed:28229507, ECO:0000269|PubMed:28834754, ECO:0000269|PubMed:29610582, ECO:0000269|PubMed:29670289}. |
| Q9Y490 | TLN1 | S1503 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| Q9Y4J8 | DTNA | S609 | ochoa | Dystrobrevin alpha (DTN-A) (Alpha-dystrobrevin) (Dystrophin-related protein 3) | May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors. |
| Q9Y623 | MYH4 | S646 | ochoa | Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) | Muscle contraction. |
| Q9Y678 | COPG1 | S554 | ochoa | Coatomer subunit gamma-1 (Gamma-1-coat protein) (Gamma-1-COP) | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte triglyceride lipase (PNPLA2) with the lipid droplet surface to mediate lipolysis (By similarity). {ECO:0000250, ECO:0000269|PubMed:20674546}. |
| Q9Y6I4 | USP3 | S210 | ochoa | Ubiquitin carboxyl-terminal hydrolase 3 (EC 3.4.19.12) (Deubiquitinating enzyme 3) (Ubiquitin thioesterase 3) (Ubiquitin-specific-processing protease 3) | Deubiquitinase that plays a role in several cellular processes including transcriptional regulation, cell cycle progression or innate immunity. In response to DNA damage, deubiquitinates monoubiquitinated target proteins such as histone H2A and H2AX and thereby counteracts RNF168- and RNF8-mediated ubiquitination. In turn, participates in the recruitment of DNA damage repair factors to DNA break sites (PubMed:24196443). Required for proper progression through S phase and subsequent mitotic entry (PubMed:17980597). Acts as a positive regulator of TP53 by deubiquitinating and stabilizing it to promote normal cell proliferation and transformation (PubMed:28807825). Participates in establishing tolerance innate immune memory through non-transcriptional feedback. Mechanistically, negatively regulates TLR-induced NF-kappa-B signaling by targeting and removing the 'Lys-63'-linked polyubiquitin chains on MYD88 (PubMed:37971847). Negatively regulates the activation of type I interferon signaling by mediating 'Lys-63'-linked polyubiquitin chains on RIGI and IFIH1 (PubMed:24366338). Also deubiquinates ASC/PYCARD, the central adapter mediating the assembly and activation of most inflammasomes, and thereby promotes inflammasome activation (PubMed:36050480). {ECO:0000269|PubMed:17980597, ECO:0000269|PubMed:24196443, ECO:0000269|PubMed:24366338, ECO:0000269|PubMed:28807825, ECO:0000269|PubMed:36050480, ECO:0000269|PubMed:37971847}. |
| Q9Y6M1 | IGF2BP2 | S312 | ochoa | Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2 mRNA-binding protein 2) (IMP-2) (Hepatocellular carcinoma autoantigen p62) (IGF-II mRNA-binding protein 2) (VICKZ family member 2) | RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (PubMed:29476152). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs (PubMed:9891060). Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts. Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD (PubMed:29476152). {ECO:0000250, ECO:0000269|PubMed:23640942, ECO:0000269|PubMed:29476152, ECO:0000269|PubMed:9891060}. |
| O00231 | PSMD11 | S298 | Sugiyama | 26S proteasome non-ATPase regulatory subunit 11 (26S proteasome regulatory subunit RPN6) (26S proteasome regulatory subunit S9) (26S proteasome regulatory subunit p44.5) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity. {ECO:0000269|PubMed:1317798, ECO:0000269|PubMed:22972301}. |
| Q9NS23 | RASSF1 | S188 | SIGNOR | Ras association domain-containing protein 1 | Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage. {ECO:0000269|PubMed:10888881, ECO:0000269|PubMed:11333291, ECO:0000269|PubMed:12024041, ECO:0000269|PubMed:14743218, ECO:0000269|PubMed:15109305, ECO:0000269|PubMed:15949439, ECO:0000269|PubMed:16510573, ECO:0000269|PubMed:18566590, ECO:0000269|PubMed:21199877}. |
| O75330 | HMMR | S344 | Sugiyama | Hyaluronan mediated motility receptor (Intracellular hyaluronic acid-binding protein) (Receptor for hyaluronan-mediated motility) (CD antigen CD168) | Receptor for hyaluronic acid (HA) (By similarity). Involved in cell motility (By similarity). When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity. May act as a regulator of adipogenisis (By similarity). {ECO:0000250|UniProtKB:Q00547}. |
| P26640 | VARS1 | S613 | Sugiyama | Valine--tRNA ligase (EC 6.1.1.9) (Protein G7a) (Valyl-tRNA synthetase) (ValRS) | Catalyzes the attachment of valine to tRNA(Val). {ECO:0000269|PubMed:8428657}. |
| P33176 | KIF5B | S718 | Sugiyama | Kinesin-1 heavy chain (Conventional kinesin heavy chain) (Ubiquitous kinesin heavy chain) (UKHC) | Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends (Probable). Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). {ECO:0000250|UniProtKB:Q2PQA9, ECO:0000250|UniProtKB:Q61768, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:24088571, ECO:0000305|PubMed:22172677, ECO:0000305|PubMed:24088571}. |
| P43121 | MCAM | S93 | Sugiyama | Cell surface glycoprotein MUC18 (Cell surface glycoprotein P1H12) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (Melanoma-associated antigen MUC18) (S-endo 1 endothelial-associated antigen) (CD antigen CD146) | Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as a surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. {ECO:0000269|PubMed:11036077, ECO:0000269|PubMed:8292890}. |
| Q9Y2T3 | GDA | S263 | Sugiyama | Guanine deaminase (Guanase) (Guanine aminase) (EC 3.5.4.3) (Guanine aminohydrolase) (GAH) (p51-nedasin) | Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia. {ECO:0000269|PubMed:10075721, ECO:0000269|PubMed:22662200}. |
| P46940 | IQGAP1 | S343 | Sugiyama | Ras GTPase-activating-like protein IQGAP1 (p195) | Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Recruited to the cell cortex by interaction with ILK which allows it to cooperate with its effector DIAPH1 to locally stabilize microtubules and allow stable insertion of caveolae into the plasma membrane (By similarity). Binds to activated CDC42 but does not stimulate its GTPase activity. Associates with calmodulin. May promote neurite outgrowth (PubMed:15695813). May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest (PubMed:20883816). {ECO:0000250|UniProtKB:Q9JKF1, ECO:0000269|PubMed:15695813, ECO:0000269|PubMed:20883816}. |
| P12931 | SRC | S225 | Sugiyama | Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src) | Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors (PubMed:34234773). Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates such as AFAP1. Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1 and to localize to actin filaments. Cytoskeletal reorganization is also controlled through the phosphorylation of cortactin (CTTN) (Probable). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN) (PubMed:21411625). In addition to phosphorylating focal adhesion proteins, SRC is also active at the sites of cell-cell contact adherens junctions and phosphorylates substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1), and plakoglobin (JUP). Another type of cell-cell junction, the gap junction, is also a target for SRC, which phosphorylates connexin-43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing and phosphorylates RNA-binding proteins such as KHDRBS1 (Probable). Phosphorylates PKP3 at 'Tyr-195' in response to reactive oxygen species, which may cause the release of PKP3 from desmosome cell junctions into the cytoplasm (PubMed:25501895). Also plays a role in PDGF-mediated tyrosine phosphorylation of both STAT1 and STAT3, leading to increased DNA binding activity of these transcription factors (By similarity). Involved in the RAS pathway through phosphorylation of RASA1 and RASGRF1 (PubMed:11389730). Plays a role in EGF-mediated calcium-activated chloride channel activation (PubMed:18586953). Required for epidermal growth factor receptor (EGFR) internalization through phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr-1477'. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization through phosphorylation and activation of GRK2, leading to beta-arrestin phosphorylation and internalization. Has a critical role in the stimulation of the CDK20/MAPK3 mitogen-activated protein kinase cascade by epidermal growth factor (Probable). Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus (PubMed:7853507). Plays an important role in osteoclastic bone resorption in conjunction with PTK2B/PYK2. Both the formation of a SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for this function. Recruited to activated integrins by PTK2B/PYK2, thereby phosphorylating CBL, which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:14585963, PubMed:8755529). Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase (PubMed:12615910). Phosphorylates DDR2 on tyrosine residues, thereby promoting its subsequent autophosphorylation (PubMed:16186108). Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731' (PubMed:20100835, PubMed:21309750). Enhances RIGI-elicited antiviral signaling (PubMed:19419966). Phosphorylates PDPK1 at 'Tyr-9', 'Tyr-373' and 'Tyr-376' (PubMed:14585963). Phosphorylates BCAR1 at 'Tyr-128' (PubMed:22710723). Phosphorylates CBLC at multiple tyrosine residues, phosphorylation at 'Tyr-341' activates CBLC E3 activity (PubMed:20525694). Phosphorylates synaptic vesicle protein synaptophysin (SYP) (By similarity). Involved in anchorage-independent cell growth (PubMed:19307596). Required for podosome formation (By similarity). Mediates IL6 signaling by activating YAP1-NOTCH pathway to induce inflammation-induced epithelial regeneration (PubMed:25731159). Phosphorylates OTUB1, promoting deubiquitination of RPTOR (PubMed:35927303). Phosphorylates caspase CASP8 at 'Tyr-380' which negatively regulates CASP8 processing and activation, down-regulating CASP8 proapoptotic function (PubMed:16619028). {ECO:0000250|UniProtKB:P05480, ECO:0000250|UniProtKB:Q9WUD9, ECO:0000269|PubMed:11389730, ECO:0000269|PubMed:12615910, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:16186108, ECO:0000269|PubMed:16619028, ECO:0000269|PubMed:18586953, ECO:0000269|PubMed:19307596, ECO:0000269|PubMed:19419966, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:20525694, ECO:0000269|PubMed:21309750, ECO:0000269|PubMed:21411625, ECO:0000269|PubMed:22710723, ECO:0000269|PubMed:25501895, ECO:0000269|PubMed:25731159, ECO:0000269|PubMed:34234773, ECO:0000269|PubMed:35927303, ECO:0000269|PubMed:7853507, ECO:0000269|PubMed:8755529, ECO:0000269|PubMed:8759729, ECO:0000305|PubMed:11964124, ECO:0000305|PubMed:8672527, ECO:0000305|PubMed:9442882}.; FUNCTION: [Isoform 1]: Non-receptor protein tyrosine kinase which phosphorylates synaptophysin with high affinity. {ECO:0000250|UniProtKB:Q9WUD9}.; FUNCTION: [Isoform 2]: Non-receptor protein tyrosine kinase which shows higher basal kinase activity than isoform 1, possibly due to weakened intramolecular interactions which enhance autophosphorylation of Tyr-419 and subsequent activation (By similarity). The SH3 domain shows reduced affinity with the linker sequence between the SH2 and kinase domains which may account for the increased basal activity (By similarity). Displays altered substrate specificity compared to isoform 1, showing weak affinity for synaptophysin and for peptide substrates containing class I or class II SH3 domain-binding motifs (By similarity). Plays a role in L1CAM-mediated neurite elongation, possibly by acting downstream of L1CAM to drive cytoskeletal rearrangements involved in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q9WUD9}.; FUNCTION: [Isoform 3]: Non-receptor protein tyrosine kinase which shows higher basal kinase activity than isoform 1, possibly due to weakened intramolecular interactions which enhance autophosphorylation of Tyr-419 and subsequent activation (By similarity). The SH3 domain shows reduced affinity with the linker sequence between the SH2 and kinase domains which may account for the increased basal activity (By similarity). Displays altered substrate specificity compared to isoform 1, showing weak affinity for synaptophysin and for peptide substrates containing class I or class II SH3 domain-binding motifs (By similarity). Plays a role in neurite elongation (By similarity). {ECO:0000250|UniProtKB:Q9WUD9}. |
| P35368 | ADRA1B | S406 | SIGNOR|iPTMNet|EPSD | Alpha-1B adrenergic receptor (Alpha-1B adrenoreceptor) (Alpha-1B adrenoceptor) | This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes. {ECO:0000269|PubMed:18802028, ECO:0000269|PubMed:22120526}. |
| Q16836 | HADH | S196 | Sugiyama | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HCDH) (EC 1.1.1.35) (Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase) (Short-chain 3-hydroxyacyl-CoA dehydrogenase) | Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10) (PubMed:10231530, PubMed:11489939, PubMed:16725361). Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion (By similarity). Plays a role in the maintenance of normal spermatogenesis through the reduction of fatty acid accumulation in the testes (By similarity). {ECO:0000250|UniProtKB:Q61425, ECO:0000269|PubMed:10231530, ECO:0000269|PubMed:11489939, ECO:0000269|PubMed:16725361}. |
| P27361 | MAPK3 | S159 | Sugiyama | Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (Microtubule-associated protein 2 kinase) (p44-ERK1) | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway (PubMed:34497368). MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade also plays a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, DEPTOR, FRS2 or GRB10) (PubMed:35216969). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. {ECO:0000269|PubMed:10393181, ECO:0000269|PubMed:10617468, ECO:0000269|PubMed:12110590, ECO:0000269|PubMed:12356731, ECO:0000269|PubMed:12974390, ECO:0000269|PubMed:15788397, ECO:0000269|PubMed:15952796, ECO:0000269|PubMed:16581800, ECO:0000269|PubMed:19265199, ECO:0000269|PubMed:34497368, ECO:0000269|PubMed:35216969, ECO:0000269|PubMed:8325880, ECO:0000269|PubMed:9155018, ECO:0000269|PubMed:9480836}. |
| P28482 | MAPK1 | S142 | Sugiyama | Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade also plays a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1 and FXR1) and a variety of other signaling-related molecules (like ARHGEF2, DCC, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. Mediates phosphorylation of TPR in response to EGF stimulation. May play a role in the spindle assembly checkpoint. Phosphorylates PML and promotes its interaction with PIN1, leading to PML degradation. Phosphorylates CDK2AP2 (By similarity). Phosphorylates phosphoglycerate kinase PGK1 under hypoxic conditions to promote its targeting to the mitochondrion and suppress the formation of acetyl-coenzyme A from pyruvate (PubMed:26942675). {ECO:0000250|UniProtKB:P63086, ECO:0000269|PubMed:10617468, ECO:0000269|PubMed:10637505, ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:12110590, ECO:0000269|PubMed:12356731, ECO:0000269|PubMed:12792650, ECO:0000269|PubMed:12794087, ECO:0000269|PubMed:12974390, ECO:0000269|PubMed:15184391, ECO:0000269|PubMed:15241487, ECO:0000269|PubMed:15616583, ECO:0000269|PubMed:15664191, ECO:0000269|PubMed:15788397, ECO:0000269|PubMed:15952796, ECO:0000269|PubMed:16581800, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:19265199, ECO:0000269|PubMed:19879846, ECO:0000269|PubMed:22033920, ECO:0000269|PubMed:26942675, ECO:0000269|PubMed:32721402, ECO:0000269|PubMed:7588608, ECO:0000269|PubMed:8622688, ECO:0000269|PubMed:9480836, ECO:0000269|PubMed:9596579, ECO:0000269|PubMed:9649500, ECO:0000269|PubMed:9687510, ECO:0000303|PubMed:15526160, ECO:0000303|PubMed:16393692, ECO:0000303|PubMed:19565474, ECO:0000303|PubMed:21779493}.; FUNCTION: Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity. {ECO:0000269|PubMed:19879846}. |
| P31152 | MAPK4 | S142 | Sugiyama | Mitogen-activated protein kinase 4 (MAP kinase 4) (MAPK 4) (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63-MAPK) | Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle (By similarity). {ECO:0000250}. |
| Q16659 | MAPK6 | S145 | Sugiyama | Mitogen-activated protein kinase 6 (MAP kinase 6) (MAPK 6) (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97-MAPK) | Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity). {ECO:0000250}. |
| P40227 | CCT6A | S455 | Sugiyama | T-complex protein 1 subunit zeta (TCP-1-zeta) (EC 3.6.1.-) (Acute morphine dependence-related protein 2) (CCT-zeta-1) (Chaperonin containing T-complex polypeptide 1 subunit 6A) (HTR3) (Tcp20) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). {ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| O60488 | ACSL4 | S584 | Sugiyama | Long-chain-fatty-acid--CoA ligase 4 (EC 6.2.1.3) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 4) (LACS 4) | Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:21242590, PubMed:22633490, PubMed:24269233). Preferentially activates arachidonate and eicosapentaenoate as substrates (PubMed:21242590). Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET. Modulates glucose-stimulated insulin secretion by regulating the levels of unesterified EETs (By similarity). Modulates prostaglandin E2 secretion (PubMed:21242590). {ECO:0000250|UniProtKB:O35547, ECO:0000269|PubMed:21242590, ECO:0000269|PubMed:22633490, ECO:0000269|PubMed:24269233}. |
| Q13164 | MAPK7 | S175 | Sugiyama | Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5) | Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via interaction with STUB1/CHIP and promotion of STUB1-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity). May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction. {ECO:0000250|UniProtKB:P0C865, ECO:0000269|PubMed:11254654, ECO:0000269|PubMed:11278431, ECO:0000269|PubMed:22869143, ECO:0000269|PubMed:9384584, ECO:0000269|PubMed:9790194}. |
| O60664 | PLIN3 | S254 | Sugiyama | Perilipin-3 (47 kDa mannose 6-phosphate receptor-binding protein) (47 kDa MPR-binding protein) (Cargo selection protein TIP47) (Mannose-6-phosphate receptor-binding protein 1) (Placental protein 17) (PP17) | Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757). Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (PubMed:9590177). {ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:9590177}. |
| Q9UQE7 | SMC3 | S961 | Sugiyama | Structural maintenance of chromosomes protein 3 (SMC protein 3) (SMC-3) (Basement membrane-associated chondroitin proteoglycan) (Bamacan) (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP) | Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement. {ECO:0000269|PubMed:11076961, ECO:0000269|PubMed:19907496}. |
| P51812 | RPS6KA3 | S66 | Sugiyama | Ribosomal protein S6 kinase alpha-3 (S6K-alpha-3) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (p90RSK3) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPK-activated protein kinase 1b) (MAPKAP kinase 1b) (MAPKAPK-1b) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1 (PubMed:16213824, PubMed:16223362, PubMed:17360704, PubMed:9770464). In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at 'Ser-10', which results in the subsequent transcriptional activation of several immediate-early genes (PubMed:10436156, PubMed:9770464). In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP (PubMed:16223362). Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity (PubMed:8250835). Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the preinitiation complex (PubMed:17360704). In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation (PubMed:18508509, PubMed:18813292). Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway (PubMed:18722121). Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function (PubMed:16213824). Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4) (PubMed:18508509, PubMed:18813292). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression (By similarity). In LPS-stimulated dendritic cells, is involved in TLR4-induced macropinocytosis, and in myeloma cells, acts as effector of FGFR3-mediated transformation signaling, after direct phosphorylation at Tyr-529 by FGFR3 (By similarity). Negatively regulates EGF-induced MAPK1/3 phosphorylation via phosphorylation of SOS1 (By similarity). Phosphorylates SOS1 at 'Ser-1134' and 'Ser-1161' that create YWHAB and YWHAE binding sites and which contribute to the negative regulation of MAPK1/3 phosphorylation (By similarity). Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630). Acts as a regulator of osteoblast differentiation by mediating phosphorylation of ATF4, thereby promoting ATF4 transactivation activity (By similarity). {ECO:0000250|UniProtKB:P18654, ECO:0000269|PubMed:10436156, ECO:0000269|PubMed:16213824, ECO:0000269|PubMed:16223362, ECO:0000269|PubMed:17360704, ECO:0000269|PubMed:18722121, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:8250835, ECO:0000269|PubMed:9770464, ECO:0000303|PubMed:18508509, ECO:0000303|PubMed:18813292}. |
| Q15349 | RPS6KA2 | S57 | Sugiyama | Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells. {ECO:0000269|PubMed:16878154, ECO:0000269|PubMed:7623830}. |
| Q16539 | MAPK14 | S143 | Sugiyama | Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAP kinase MXI2) (MAX-interacting protein 2) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a) (SAPK2a) | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1 (PubMed:9687510, PubMed:9792677). RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery (PubMed:9687510, PubMed:9792677). On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2 (PubMed:11154262). MAPK14 also interacts with casein kinase II, leading to its activation through autophosphorylation and further phosphorylation of TP53/p53 (PubMed:10747897). In the cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. In a similar way, MAPK14 phosphorylates the ubiquitin ligase SIAH2, regulating its activity towards EGLN3 (PubMed:17003045). MAPK14 may also inhibit the lysosomal degradation pathway of autophagy by interfering with the intracellular trafficking of the transmembrane protein ATG9 (PubMed:19893488). Another function of MAPK14 is to regulate the endocytosis of membrane receptors by different mechanisms that impinge on the small GTPase RAB5A. In addition, clathrin-mediated EGFR internalization induced by inflammatory cytokines and UV irradiation depends on MAPK14-mediated phosphorylation of EGFR itself as well as of RAB5A effectors (PubMed:16932740). Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17 (PubMed:20188673). Such phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR signaling and cell proliferation. Another p38 MAPK substrate is FGFR1. FGFR1 can be translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A (PubMed:10330143, PubMed:9430721, PubMed:9858528). The p38 MAPKs are emerging as important modulators of gene expression by regulating chromatin modifiers and remodelers. The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on 'Ser-10' (H3S10ph) in LPS-stimulated myeloid cells. This phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for increased NF-kappa-B recruitment. Phosphorylates CDC25B and CDC25C which is required for binding to 14-3-3 proteins and leads to initiation of a G2 delay after ultraviolet radiation (PubMed:11333986). Phosphorylates TIAR following DNA damage, releasing TIAR from GADD45A mRNA and preventing mRNA degradation (PubMed:20932473). The p38 MAPKs may also have kinase-independent roles, which are thought to be due to the binding to targets in the absence of phosphorylation. Protein O-Glc-N-acylation catalyzed by the OGT is regulated by MAPK14, and, although OGT does not seem to be phosphorylated by MAPK14, their interaction increases upon MAPK14 activation induced by glucose deprivation. This interaction may regulate OGT activity by recruiting it to specific targets such as neurofilament H, stimulating its O-Glc-N-acylation. Required in mid-fetal development for the growth of embryo-derived blood vessels in the labyrinth layer of the placenta. Also plays an essential role in developmental and stress-induced erythropoiesis, through regulation of EPO gene expression (PubMed:10943842). Isoform MXI2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform EXIP may play a role in the early onset of apoptosis. Phosphorylates S100A9 at 'Thr-113' (PubMed:15905572). Phosphorylates NLRP1 downstream of MAP3K20/ZAK in response to UV-B irradiation and ribosome collisions, promoting activation of the NLRP1 inflammasome and pyroptosis (PubMed:35857590). {ECO:0000269|PubMed:10330143, ECO:0000269|PubMed:10747897, ECO:0000269|PubMed:10943842, ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:11333986, ECO:0000269|PubMed:15905572, ECO:0000269|PubMed:16932740, ECO:0000269|PubMed:17003045, ECO:0000269|PubMed:17724032, ECO:0000269|PubMed:19893488, ECO:0000269|PubMed:20188673, ECO:0000269|PubMed:20932473, ECO:0000269|PubMed:35857590, ECO:0000269|PubMed:9430721, ECO:0000269|PubMed:9687510, ECO:0000269|PubMed:9792677, ECO:0000269|PubMed:9858528}.; FUNCTION: (Microbial infection) Activated by phosphorylation by M.tuberculosis EsxA in T-cells leading to inhibition of IFN-gamma production; phosphorylation is apparent within 15 minutes and is inhibited by kinase-specific inhibitors SB203580 and siRNA (PubMed:21586573). {ECO:0000269|PubMed:21586573}. |
| P35250 | RFC2 | S85 | Sugiyama | Replication factor C subunit 2 (Activator 1 40 kDa subunit) (A1 40 kDa subunit) (Activator 1 subunit 2) (Replication factor C 40 kDa subunit) (RF-C 40 kDa subunit) (RFC40) | Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA (PubMed:9488738). This subunit binds ATP (By similarity). {ECO:0000250, ECO:0000269|PubMed:9488738}. |
| Q01581 | HMGCS1 | S404 | Sugiyama | Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMG-CoA synthase) (EC 2.3.3.10) (3-hydroxy-3-methylglutaryl coenzyme A synthase) | Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate, a precursor for cholesterol synthesis. {ECO:0000269|PubMed:7913309}. |
| Q5JTH9 | RRP12 | S515 | Sugiyama | RRP12-like protein | None |
| P24534 | EEF1B2 | S68 | Sugiyama | Elongation factor 1-beta (EF-1-beta) (eEF-1B alpha) | Catalytic subunit of the guanine nucleotide exchange factor (GEF) (eEF1B subcomplex) of the eukaryotic elongation factor 1 complex (eEF1) (By similarity). Stimulates the exchange of GDP for GTP on elongation factor 1A (eEF1A), probably by displacing GDP from the nucleotide binding pocket in eEF1A (By similarity). {ECO:0000250|UniProtKB:P32471}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-198753 | ERK/MAPK targets | 9.520506e-08 | 7.021 |
| R-HSA-437239 | Recycling pathway of L1 | 9.332092e-08 | 7.030 |
| R-HSA-422475 | Axon guidance | 8.672322e-08 | 7.062 |
| R-HSA-9675108 | Nervous system development | 2.112642e-08 | 7.675 |
| R-HSA-438064 | Post NMDA receptor activation events | 1.227062e-07 | 6.911 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.983886e-07 | 6.702 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 6.874969e-07 | 6.163 |
| R-HSA-983189 | Kinesins | 5.407580e-07 | 6.267 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 6.028680e-07 | 6.220 |
| R-HSA-2262752 | Cellular responses to stress | 7.878452e-07 | 6.104 |
| R-HSA-68886 | M Phase | 9.158021e-07 | 6.038 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 1.187711e-06 | 5.925 |
| R-HSA-373760 | L1CAM interactions | 2.302925e-06 | 5.638 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 2.815902e-06 | 5.550 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 3.607599e-06 | 5.443 |
| R-HSA-5683057 | MAPK family signaling cascades | 3.849468e-06 | 5.415 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 4.371583e-06 | 5.359 |
| R-HSA-2559583 | Cellular Senescence | 4.623803e-06 | 5.335 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 4.869653e-06 | 5.313 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 5.630183e-06 | 5.249 |
| R-HSA-69275 | G2/M Transition | 6.334287e-06 | 5.198 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 7.017396e-06 | 5.154 |
| R-HSA-69278 | Cell Cycle, Mitotic | 7.022534e-06 | 5.154 |
| R-HSA-68877 | Mitotic Prometaphase | 9.017581e-06 | 5.045 |
| R-HSA-1640170 | Cell Cycle | 8.998264e-06 | 5.046 |
| R-HSA-913531 | Interferon Signaling | 1.393572e-05 | 4.856 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 1.421399e-05 | 4.847 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 1.529838e-05 | 4.815 |
| R-HSA-157858 | Gap junction trafficking and regulation | 1.621961e-05 | 4.790 |
| R-HSA-444257 | RSK activation | 1.838078e-05 | 4.736 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 1.889596e-05 | 4.724 |
| R-HSA-450341 | Activation of the AP-1 family of transcription factors | 2.575605e-05 | 4.589 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 2.311985e-05 | 4.636 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 3.509868e-05 | 4.455 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 3.714202e-05 | 4.430 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 4.026026e-05 | 4.395 |
| R-HSA-9646399 | Aggrephagy | 5.333694e-05 | 4.273 |
| R-HSA-2467813 | Separation of Sister Chromatids | 5.042472e-05 | 4.297 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 4.454319e-05 | 4.351 |
| R-HSA-450294 | MAP kinase activation | 5.383722e-05 | 4.269 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 5.199680e-05 | 4.284 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 5.534446e-05 | 4.257 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 5.534446e-05 | 4.257 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 5.886390e-05 | 4.230 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 6.649834e-05 | 4.177 |
| R-HSA-5674135 | MAP2K and MAPK activation | 6.696023e-05 | 4.174 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 6.696023e-05 | 4.174 |
| R-HSA-9663891 | Selective autophagy | 6.703468e-05 | 4.174 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 7.629546e-05 | 4.118 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 7.948771e-05 | 4.100 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 8.296361e-05 | 4.081 |
| R-HSA-190828 | Gap junction trafficking | 9.246292e-05 | 4.034 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 9.835229e-05 | 4.007 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 1.133757e-04 | 3.945 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 1.133757e-04 | 3.945 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 1.133757e-04 | 3.945 |
| R-HSA-6802949 | Signaling by RAS mutants | 1.133757e-04 | 3.945 |
| R-HSA-448424 | Interleukin-17 signaling | 1.145628e-04 | 3.941 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 1.181381e-04 | 3.928 |
| R-HSA-68882 | Mitotic Anaphase | 1.173793e-04 | 3.930 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 1.182880e-04 | 3.927 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 1.220356e-04 | 3.914 |
| R-HSA-2132295 | MHC class II antigen presentation | 1.319141e-04 | 3.880 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 1.336824e-04 | 3.874 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 2.220263e-04 | 3.654 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 2.495890e-04 | 3.603 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 2.719608e-04 | 3.565 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 2.818792e-04 | 3.550 |
| R-HSA-190861 | Gap junction assembly | 2.788978e-04 | 3.555 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 2.837009e-04 | 3.547 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 2.977705e-04 | 3.526 |
| R-HSA-112315 | Transmission across Chemical Synapses | 3.095884e-04 | 3.509 |
| R-HSA-187687 | Signalling to ERKs | 3.111692e-04 | 3.507 |
| R-HSA-162582 | Signal Transduction | 3.172690e-04 | 3.499 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 3.306095e-04 | 3.481 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 3.306095e-04 | 3.481 |
| R-HSA-9732724 | IFNG signaling activates MAPKs | 3.790500e-04 | 3.421 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 3.817799e-04 | 3.418 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 4.224594e-04 | 3.374 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 4.701667e-04 | 3.328 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 4.838021e-04 | 3.315 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 4.838021e-04 | 3.315 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 5.298146e-04 | 3.276 |
| R-HSA-166520 | Signaling by NTRKs | 5.298146e-04 | 3.276 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 6.227904e-04 | 3.206 |
| R-HSA-5617833 | Cilium Assembly | 6.870471e-04 | 3.163 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 7.521634e-04 | 3.124 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 9.535223e-04 | 3.021 |
| R-HSA-5610787 | Hedgehog 'off' state | 9.292147e-04 | 3.032 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 8.793209e-04 | 3.056 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 8.369975e-04 | 3.077 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 8.369975e-04 | 3.077 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 8.369975e-04 | 3.077 |
| R-HSA-109581 | Apoptosis | 9.331963e-04 | 3.030 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 1.038995e-03 | 2.983 |
| R-HSA-380287 | Centrosome maturation | 1.079353e-03 | 2.967 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 1.079353e-03 | 2.967 |
| R-HSA-202670 | ERKs are inactivated | 1.216740e-03 | 2.915 |
| R-HSA-1632852 | Macroautophagy | 1.643694e-03 | 2.784 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 1.449764e-03 | 2.839 |
| R-HSA-5358351 | Signaling by Hedgehog | 1.459430e-03 | 2.836 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 1.556760e-03 | 2.808 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 1.459724e-03 | 2.836 |
| R-HSA-9833482 | PKR-mediated signaling | 1.449764e-03 | 2.839 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 1.810149e-03 | 2.742 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 1.877178e-03 | 2.726 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 2.145571e-03 | 2.668 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 2.157262e-03 | 2.666 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 2.234704e-03 | 2.651 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 2.238681e-03 | 2.650 |
| R-HSA-199991 | Membrane Trafficking | 2.282388e-03 | 2.642 |
| R-HSA-171007 | p38MAPK events | 2.375845e-03 | 2.624 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 2.375845e-03 | 2.624 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 2.599383e-03 | 2.585 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 2.743549e-03 | 2.562 |
| R-HSA-168898 | Toll-like Receptor Cascades | 2.639615e-03 | 2.578 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 2.639618e-03 | 2.578 |
| R-HSA-9612973 | Autophagy | 2.959778e-03 | 2.529 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 2.566512e-03 | 2.591 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 2.566512e-03 | 2.591 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 2.900000e-03 | 2.538 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 2.900000e-03 | 2.538 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 2.945273e-03 | 2.531 |
| R-HSA-391251 | Protein folding | 3.007028e-03 | 2.522 |
| R-HSA-9652169 | Signaling by MAP2K mutants | 3.168726e-03 | 2.499 |
| R-HSA-112316 | Neuronal System | 3.242191e-03 | 2.489 |
| R-HSA-109582 | Hemostasis | 3.677058e-03 | 2.434 |
| R-HSA-5357801 | Programmed Cell Death | 4.129990e-03 | 2.384 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 4.162318e-03 | 2.381 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 4.889226e-03 | 2.311 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 5.150352e-03 | 2.288 |
| R-HSA-69620 | Cell Cycle Checkpoints | 5.330060e-03 | 2.273 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 5.421207e-03 | 2.266 |
| R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 5.533281e-03 | 2.257 |
| R-HSA-75876 | Synthesis of very long-chain fatty acyl-CoAs | 5.559841e-03 | 2.255 |
| R-HSA-167044 | Signalling to RAS | 5.678016e-03 | 2.246 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 6.349957e-03 | 2.197 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 6.349957e-03 | 2.197 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 6.349957e-03 | 2.197 |
| R-HSA-1266738 | Developmental Biology | 6.679207e-03 | 2.175 |
| R-HSA-75153 | Apoptotic execution phase | 6.771555e-03 | 2.169 |
| R-HSA-434313 | Intracellular metabolism of fatty acids regulates insulin secretion | 6.940720e-03 | 2.159 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 6.940720e-03 | 2.159 |
| R-HSA-199920 | CREB phosphorylation | 6.940720e-03 | 2.159 |
| R-HSA-9842640 | Signaling by LTK in cancer | 6.940720e-03 | 2.159 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 6.952249e-03 | 2.158 |
| R-HSA-1500931 | Cell-Cell communication | 7.018681e-03 | 2.154 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 8.642332e-03 | 2.063 |
| R-HSA-5620924 | Intraflagellar transport | 7.669446e-03 | 2.115 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 9.095804e-03 | 2.041 |
| R-HSA-9609690 | HCMV Early Events | 1.007159e-02 | 1.997 |
| R-HSA-877300 | Interferon gamma signaling | 1.155274e-02 | 1.937 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 1.172475e-02 | 1.931 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 1.172959e-02 | 1.931 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 1.172959e-02 | 1.931 |
| R-HSA-112411 | MAPK1 (ERK2) activation | 1.201319e-02 | 1.920 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 1.201319e-02 | 1.920 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 1.266951e-02 | 1.897 |
| R-HSA-456926 | Thrombin signalling through proteinase activated receptors (PARs) | 1.365136e-02 | 1.865 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 1.397386e-02 | 1.855 |
| R-HSA-110056 | MAPK3 (ERK1) activation | 1.397386e-02 | 1.855 |
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 1.397386e-02 | 1.855 |
| R-HSA-2151209 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation | 1.397386e-02 | 1.855 |
| R-HSA-74749 | Signal attenuation | 1.397386e-02 | 1.855 |
| R-HSA-9627069 | Regulation of the apoptosome activity | 1.397386e-02 | 1.855 |
| R-HSA-111458 | Formation of apoptosome | 1.397386e-02 | 1.855 |
| R-HSA-186712 | Regulation of beta-cell development | 1.400903e-02 | 1.854 |
| R-HSA-9635465 | Suppression of apoptosis | 1.606291e-02 | 1.794 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 1.617847e-02 | 1.791 |
| R-HSA-354192 | Integrin signaling | 1.685070e-02 | 1.773 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 1.685070e-02 | 1.773 |
| R-HSA-373755 | Semaphorin interactions | 1.694579e-02 | 1.771 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 1.694579e-02 | 1.771 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 1.694579e-02 | 1.771 |
| R-HSA-390522 | Striated Muscle Contraction | 1.800233e-02 | 1.745 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 1.800233e-02 | 1.745 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 1.827652e-02 | 1.738 |
| R-HSA-111461 | Cytochrome c-mediated apoptotic response | 1.827652e-02 | 1.738 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 1.919676e-02 | 1.717 |
| R-HSA-5653656 | Vesicle-mediated transport | 1.990830e-02 | 1.701 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 2.027808e-02 | 1.693 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 2.027808e-02 | 1.693 |
| R-HSA-5602566 | TICAM1 deficiency - HSE | 2.695583e-02 | 1.569 |
| R-HSA-5632927 | Defective Mismatch Repair Associated With MSH3 | 2.695583e-02 | 1.569 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 2.587767e-02 | 1.587 |
| R-HSA-8983432 | Interleukin-15 signaling | 2.061095e-02 | 1.686 |
| R-HSA-77348 | Beta oxidation of octanoyl-CoA to hexanoyl-CoA | 2.562776e-02 | 1.591 |
| R-HSA-77310 | Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA | 2.562776e-02 | 1.591 |
| R-HSA-77350 | Beta oxidation of hexanoyl-CoA to butanoyl-CoA | 2.562776e-02 | 1.591 |
| R-HSA-170968 | Frs2-mediated activation | 2.306256e-02 | 1.637 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 2.726467e-02 | 1.564 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 2.166731e-02 | 1.664 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 2.061095e-02 | 1.686 |
| R-HSA-8853659 | RET signaling | 2.171432e-02 | 1.663 |
| R-HSA-8953854 | Metabolism of RNA | 2.654928e-02 | 1.576 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 2.306256e-02 | 1.637 |
| R-HSA-8941326 | RUNX2 regulates bone development | 2.171432e-02 | 1.663 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 2.295370e-02 | 1.639 |
| R-HSA-446728 | Cell junction organization | 2.240254e-02 | 1.650 |
| R-HSA-418885 | DCC mediated attractive signaling | 2.830304e-02 | 1.548 |
| R-HSA-1502540 | Signaling by Activin | 2.830304e-02 | 1.548 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 2.968718e-02 | 1.527 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 3.041178e-02 | 1.517 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 3.042245e-02 | 1.517 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 3.108498e-02 | 1.507 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 3.108498e-02 | 1.507 |
| R-HSA-169893 | Prolonged ERK activation events | 3.108498e-02 | 1.507 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 3.237025e-02 | 1.490 |
| R-HSA-1989781 | PPARA activates gene expression | 3.269954e-02 | 1.485 |
| R-HSA-909733 | Interferon alpha/beta signaling | 3.313081e-02 | 1.480 |
| R-HSA-9609646 | HCMV Infection | 3.343614e-02 | 1.476 |
| R-HSA-5654743 | Signaling by FGFR4 | 3.349904e-02 | 1.475 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 3.353682e-02 | 1.474 |
| R-HSA-5654738 | Signaling by FGFR2 | 3.353682e-02 | 1.474 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 3.396586e-02 | 1.469 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 3.397022e-02 | 1.469 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 3.397022e-02 | 1.469 |
| R-HSA-77346 | Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA | 3.397022e-02 | 1.469 |
| R-HSA-421270 | Cell-cell junction organization | 3.405445e-02 | 1.468 |
| R-HSA-376176 | Signaling by ROBO receptors | 3.413001e-02 | 1.467 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 3.427760e-02 | 1.465 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 3.594286e-02 | 1.444 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 3.687021e-02 | 1.433 |
| R-HSA-5654741 | Signaling by FGFR3 | 3.687021e-02 | 1.433 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 3.695547e-02 | 1.432 |
| R-HSA-9827857 | Specification of primordial germ cells | 3.695547e-02 | 1.432 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 3.698508e-02 | 1.432 |
| R-HSA-68875 | Mitotic Prophase | 3.798991e-02 | 1.420 |
| R-HSA-9675135 | Diseases of DNA repair | 3.861866e-02 | 1.413 |
| R-HSA-3371556 | Cellular response to heat stress | 3.901134e-02 | 1.409 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 3.901134e-02 | 1.409 |
| R-HSA-3928664 | Ephrin signaling | 4.003751e-02 | 1.398 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 4.003751e-02 | 1.398 |
| R-HSA-9831926 | Nephron development | 4.003751e-02 | 1.398 |
| R-HSA-111471 | Apoptotic factor-mediated response | 4.003751e-02 | 1.398 |
| R-HSA-5619050 | Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tu... | 4.016124e-02 | 1.396 |
| R-HSA-5602571 | TRAF3 deficiency - HSE | 4.016124e-02 | 1.396 |
| R-HSA-5632928 | Defective Mismatch Repair Associated With MSH2 | 4.016124e-02 | 1.396 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 4.110417e-02 | 1.386 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 4.238445e-02 | 1.373 |
| R-HSA-416476 | G alpha (q) signalling events | 4.280938e-02 | 1.368 |
| R-HSA-9766229 | Degradation of CDH1 | 4.411261e-02 | 1.355 |
| R-HSA-445144 | Signal transduction by L1 | 4.647942e-02 | 1.333 |
| R-HSA-1181150 | Signaling by NODAL | 4.647942e-02 | 1.333 |
| R-HSA-69481 | G2/M Checkpoints | 4.662945e-02 | 1.331 |
| R-HSA-198765 | Signalling to ERK5 | 5.318825e-02 | 1.274 |
| R-HSA-3828062 | Glycogen storage disease type 0 (muscle GYS1) | 5.318825e-02 | 1.274 |
| R-HSA-3814836 | Glycogen storage disease type XV (GYG1) | 5.318825e-02 | 1.274 |
| R-HSA-209563 | Axonal growth stimulation | 6.603925e-02 | 1.180 |
| R-HSA-8941237 | Invadopodia formation | 6.603925e-02 | 1.180 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 6.039052e-02 | 1.219 |
| R-HSA-191859 | snRNP Assembly | 6.502949e-02 | 1.187 |
| R-HSA-194441 | Metabolism of non-coding RNA | 6.502949e-02 | 1.187 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 5.869746e-02 | 1.231 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 5.327155e-02 | 1.274 |
| R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 6.406555e-02 | 1.193 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 5.014673e-02 | 1.300 |
| R-HSA-525793 | Myogenesis | 7.163313e-02 | 1.145 |
| R-HSA-5423599 | Diseases of Mismatch Repair (MMR) | 6.603925e-02 | 1.180 |
| R-HSA-420029 | Tight junction interactions | 6.781397e-02 | 1.169 |
| R-HSA-1474165 | Reproduction | 5.135295e-02 | 1.289 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 6.781397e-02 | 1.169 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 6.881938e-02 | 1.162 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 6.406555e-02 | 1.193 |
| R-HSA-8863678 | Neurodegenerative Diseases | 6.406555e-02 | 1.193 |
| R-HSA-70171 | Glycolysis | 6.707345e-02 | 1.173 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 6.039052e-02 | 1.219 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 7.001385e-02 | 1.155 |
| R-HSA-400451 | Free fatty acids regulate insulin secretion | 6.039052e-02 | 1.219 |
| R-HSA-9764561 | Regulation of CDH1 Function | 6.053559e-02 | 1.218 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 6.733255e-02 | 1.172 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 4.968541e-02 | 1.304 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 4.968541e-02 | 1.304 |
| R-HSA-190236 | Signaling by FGFR | 6.365202e-02 | 1.196 |
| R-HSA-5654736 | Signaling by FGFR1 | 5.834557e-02 | 1.234 |
| R-HSA-982772 | Growth hormone receptor signaling | 6.039052e-02 | 1.219 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 7.204886e-02 | 1.142 |
| R-HSA-111885 | Opioid Signalling | 7.419676e-02 | 1.130 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 7.552046e-02 | 1.122 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 7.552046e-02 | 1.122 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 7.552046e-02 | 1.122 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 7.552046e-02 | 1.122 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 7.639268e-02 | 1.117 |
| R-HSA-74751 | Insulin receptor signalling cascade | 7.690917e-02 | 1.114 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 7.871660e-02 | 1.104 |
| R-HSA-191650 | Regulation of gap junction activity | 7.871660e-02 | 1.104 |
| R-HSA-8964540 | Alanine metabolism | 7.871660e-02 | 1.104 |
| R-HSA-203754 | NOSIP mediated eNOS trafficking | 9.122264e-02 | 1.040 |
| R-HSA-5576894 | Phase 1 - inactivation of fast Na+ channels | 1.035597e-01 | 0.985 |
| R-HSA-9652817 | Signaling by MAPK mutants | 1.035597e-01 | 0.985 |
| R-HSA-9645135 | STAT5 Activation | 1.157300e-01 | 0.937 |
| R-HSA-203641 | NOSTRIN mediated eNOS trafficking | 1.277358e-01 | 0.894 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 1.277358e-01 | 0.894 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 1.277358e-01 | 0.894 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 1.395794e-01 | 0.855 |
| R-HSA-3785653 | Myoclonic epilepsy of Lafora | 1.395794e-01 | 0.855 |
| R-HSA-9613354 | Lipophagy | 1.512628e-01 | 0.820 |
| R-HSA-9020958 | Interleukin-21 signaling | 1.512628e-01 | 0.820 |
| R-HSA-73843 | 5-Phosphoribose 1-diphosphate biosynthesis | 1.512628e-01 | 0.820 |
| R-HSA-9700645 | ALK mutants bind TKIs | 1.512628e-01 | 0.820 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 1.627884e-01 | 0.788 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 1.627884e-01 | 0.788 |
| R-HSA-164843 | 2-LTR circle formation | 1.627884e-01 | 0.788 |
| R-HSA-9615710 | Late endosomal microautophagy | 8.348950e-02 | 1.078 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 8.348950e-02 | 1.078 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 8.756632e-02 | 1.058 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 9.170149e-02 | 1.038 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 9.170149e-02 | 1.038 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 1.001377e-01 | 0.999 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 1.001377e-01 | 0.999 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 1.044342e-01 | 0.981 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 1.044342e-01 | 0.981 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 1.131734e-01 | 0.946 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 1.220934e-01 | 0.913 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 1.311783e-01 | 0.882 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 1.357778e-01 | 0.867 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 1.387921e-01 | 0.858 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 1.387921e-01 | 0.858 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 8.348950e-02 | 1.078 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 1.404129e-01 | 0.853 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 9.155471e-02 | 1.038 |
| R-HSA-9603381 | Activated NTRK3 signals through PI3K | 1.277358e-01 | 0.894 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 9.155471e-02 | 1.038 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 1.087802e-01 | 0.963 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 1.177569e-01 | 0.929 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 1.087802e-01 | 0.963 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 1.357778e-01 | 0.867 |
| R-HSA-451927 | Interleukin-2 family signaling | 1.357778e-01 | 0.867 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 1.087802e-01 | 0.963 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 8.348950e-02 | 1.078 |
| R-HSA-1500620 | Meiosis | 1.356847e-01 | 0.867 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 1.001377e-01 | 0.999 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 1.235065e-01 | 0.908 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 1.087802e-01 | 0.963 |
| R-HSA-8985947 | Interleukin-9 signaling | 1.395794e-01 | 0.855 |
| R-HSA-193697 | p75NTR regulates axonogenesis | 1.512628e-01 | 0.820 |
| R-HSA-190873 | Gap junction degradation | 1.512628e-01 | 0.820 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 9.170149e-02 | 1.038 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 1.087802e-01 | 0.963 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 1.220934e-01 | 0.913 |
| R-HSA-6798695 | Neutrophil degranulation | 1.220015e-01 | 0.914 |
| R-HSA-1433557 | Signaling by SCF-KIT | 1.545136e-01 | 0.811 |
| R-HSA-1592230 | Mitochondrial biogenesis | 1.062729e-01 | 0.974 |
| R-HSA-9020956 | Interleukin-27 signaling | 1.627884e-01 | 0.788 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 1.450817e-01 | 0.838 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 1.019629e-01 | 0.992 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 1.044342e-01 | 0.981 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 1.266162e-01 | 0.898 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 9.771756e-02 | 1.010 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 1.088883e-01 | 0.963 |
| R-HSA-194138 | Signaling by VEGF | 1.266546e-01 | 0.897 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 1.131734e-01 | 0.946 |
| R-HSA-193634 | Axonal growth inhibition (RHOA activation) | 1.395794e-01 | 0.855 |
| R-HSA-111995 | phospho-PLA2 pathway | 1.395794e-01 | 0.855 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 1.512628e-01 | 0.820 |
| R-HSA-426048 | Arachidonate production from DAG | 1.627884e-01 | 0.788 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 9.589271e-02 | 1.018 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 1.131734e-01 | 0.946 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 1.131734e-01 | 0.946 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 1.450817e-01 | 0.838 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 1.450817e-01 | 0.838 |
| R-HSA-180746 | Nuclear import of Rev protein | 1.087802e-01 | 0.963 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 1.131734e-01 | 0.946 |
| R-HSA-4641258 | Degradation of DVL | 1.220934e-01 | 0.913 |
| R-HSA-73864 | RNA Polymerase I Transcription | 1.146514e-01 | 0.941 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 1.450817e-01 | 0.838 |
| R-HSA-5689603 | UCH proteinases | 1.088883e-01 | 0.963 |
| R-HSA-373752 | Netrin-1 signaling | 1.592733e-01 | 0.798 |
| R-HSA-418886 | Netrin mediated repulsion signals | 1.277358e-01 | 0.894 |
| R-HSA-390696 | Adrenoceptors | 1.395794e-01 | 0.855 |
| R-HSA-425986 | Sodium/Proton exchangers | 1.395794e-01 | 0.855 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 9.170149e-02 | 1.038 |
| R-HSA-399719 | Trafficking of AMPA receptors | 9.170149e-02 | 1.038 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 1.176118e-01 | 0.930 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 1.176118e-01 | 0.930 |
| R-HSA-4641257 | Degradation of AXIN | 1.220934e-01 | 0.913 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 1.220934e-01 | 0.913 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 1.357778e-01 | 0.867 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 1.357778e-01 | 0.867 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 1.404129e-01 | 0.853 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 1.032424e-01 | 0.986 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 1.044342e-01 | 0.981 |
| R-HSA-8939211 | ESR-mediated signaling | 1.422654e-01 | 0.847 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 9.122264e-02 | 1.040 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 1.395794e-01 | 0.855 |
| R-HSA-428542 | Regulation of commissural axon pathfinding by SLIT and ROBO | 1.512628e-01 | 0.820 |
| R-HSA-9930044 | Nuclear RNA decay | 1.001377e-01 | 0.999 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 1.044342e-01 | 0.981 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 1.087802e-01 | 0.963 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 1.087802e-01 | 0.963 |
| R-HSA-169911 | Regulation of Apoptosis | 1.131734e-01 | 0.946 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 1.266162e-01 | 0.898 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 1.450817e-01 | 0.838 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 1.450817e-01 | 0.838 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 1.229878e-01 | 0.910 |
| R-HSA-9907900 | Proteasome assembly | 1.592733e-01 | 0.798 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 8.168763e-02 | 1.088 |
| R-HSA-9700206 | Signaling by ALK in cancer | 8.168763e-02 | 1.088 |
| R-HSA-9634635 | Estrogen-stimulated signaling through PRKCZ | 1.512628e-01 | 0.820 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 1.311783e-01 | 0.882 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 1.357778e-01 | 0.867 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 1.404129e-01 | 0.853 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 1.404129e-01 | 0.853 |
| R-HSA-4086400 | PCP/CE pathway | 1.146514e-01 | 0.941 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 1.387921e-01 | 0.858 |
| R-HSA-392518 | Signal amplification | 1.087802e-01 | 0.963 |
| R-HSA-2559585 | Oncogene Induced Senescence | 1.131734e-01 | 0.946 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 1.497825e-01 | 0.825 |
| R-HSA-70326 | Glucose metabolism | 1.062729e-01 | 0.974 |
| R-HSA-9032500 | Activated NTRK2 signals through FYN | 1.395794e-01 | 0.855 |
| R-HSA-8934903 | Receptor Mediated Mitophagy | 1.627884e-01 | 0.788 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 1.311783e-01 | 0.882 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 1.311783e-01 | 0.882 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 1.545136e-01 | 0.811 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 1.592733e-01 | 0.798 |
| R-HSA-5632684 | Hedgehog 'on' state | 9.500186e-02 | 1.022 |
| R-HSA-9645723 | Diseases of programmed cell death | 1.482567e-01 | 0.829 |
| R-HSA-162909 | Host Interactions of HIV factors | 1.219900e-01 | 0.914 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 1.612315e-01 | 0.793 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 1.263915e-01 | 0.898 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 1.001377e-01 | 0.999 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 1.404129e-01 | 0.853 |
| R-HSA-5688426 | Deubiquitination | 8.516111e-02 | 1.070 |
| R-HSA-5689880 | Ub-specific processing proteases | 1.246791e-01 | 0.904 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 9.231795e-02 | 1.035 |
| R-HSA-180024 | DARPP-32 events | 8.348950e-02 | 1.078 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 9.231795e-02 | 1.035 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 1.044342e-01 | 0.981 |
| R-HSA-111996 | Ca-dependent events | 1.497825e-01 | 0.825 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 1.426238e-01 | 0.846 |
| R-HSA-69541 | Stabilization of p53 | 1.311783e-01 | 0.882 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 1.545136e-01 | 0.811 |
| R-HSA-191273 | Cholesterol biosynthesis | 1.146514e-01 | 0.941 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 1.253626e-01 | 0.902 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 1.087802e-01 | 0.963 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 1.087802e-01 | 0.963 |
| R-HSA-163685 | Integration of energy metabolism | 1.587055e-01 | 0.799 |
| R-HSA-418990 | Adherens junctions interactions | 1.098395e-01 | 0.959 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 1.592733e-01 | 0.798 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 1.220934e-01 | 0.913 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 9.589271e-02 | 1.018 |
| R-HSA-5633007 | Regulation of TP53 Activity | 9.878562e-02 | 1.005 |
| R-HSA-9948299 | Ribosome-associated quality control | 1.638834e-01 | 0.785 |
| R-HSA-77286 | mitochondrial fatty acid beta-oxidation of saturated fatty acids | 1.640600e-01 | 0.785 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 1.640600e-01 | 0.785 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 1.640600e-01 | 0.785 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 1.640600e-01 | 0.785 |
| R-HSA-9824272 | Somitogenesis | 1.640600e-01 | 0.785 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 1.644745e-01 | 0.784 |
| R-HSA-2682334 | EPH-Ephrin signaling | 1.644745e-01 | 0.784 |
| R-HSA-74752 | Signaling by Insulin receptor | 1.644745e-01 | 0.784 |
| R-HSA-6807070 | PTEN Regulation | 1.664951e-01 | 0.779 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 1.677799e-01 | 0.775 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 1.686629e-01 | 0.773 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 1.688720e-01 | 0.772 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 1.688720e-01 | 0.772 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 1.691218e-01 | 0.772 |
| R-HSA-9664407 | Parasite infection | 1.691218e-01 | 0.772 |
| R-HSA-9664417 | Leishmania phagocytosis | 1.691218e-01 | 0.772 |
| R-HSA-168256 | Immune System | 1.701775e-01 | 0.769 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 1.737078e-01 | 0.760 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 1.741581e-01 | 0.759 |
| R-HSA-9020558 | Interleukin-2 signaling | 1.741581e-01 | 0.759 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 1.741581e-01 | 0.759 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 1.741581e-01 | 0.759 |
| R-HSA-425381 | Bicarbonate transporters | 1.741581e-01 | 0.759 |
| R-HSA-210990 | PECAM1 interactions | 1.741581e-01 | 0.759 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 1.741581e-01 | 0.759 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 1.785660e-01 | 0.748 |
| R-HSA-9634597 | GPER1 signaling | 1.785660e-01 | 0.748 |
| R-HSA-70263 | Gluconeogenesis | 1.785660e-01 | 0.748 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 1.785660e-01 | 0.748 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 1.811905e-01 | 0.742 |
| R-HSA-73893 | DNA Damage Bypass | 1.834449e-01 | 0.736 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 1.834449e-01 | 0.736 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 1.834449e-01 | 0.736 |
| R-HSA-157579 | Telomere Maintenance | 1.845879e-01 | 0.734 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 1.845879e-01 | 0.734 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 1.845879e-01 | 0.734 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 1.853741e-01 | 0.732 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 1.853741e-01 | 0.732 |
| R-HSA-416550 | Sema4D mediated inhibition of cell attachment and migration | 1.853741e-01 | 0.732 |
| R-HSA-162592 | Integration of provirus | 1.853741e-01 | 0.732 |
| R-HSA-422356 | Regulation of insulin secretion | 1.880021e-01 | 0.726 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 1.891609e-01 | 0.723 |
| R-HSA-912446 | Meiotic recombination | 1.932594e-01 | 0.714 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 1.932594e-01 | 0.714 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 1.932594e-01 | 0.714 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 1.932594e-01 | 0.714 |
| R-HSA-69242 | S Phase | 1.933917e-01 | 0.714 |
| R-HSA-72172 | mRNA Splicing | 1.938343e-01 | 0.713 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 1.948791e-01 | 0.710 |
| R-HSA-382556 | ABC-family proteins mediated transport | 1.948791e-01 | 0.710 |
| R-HSA-77305 | Beta oxidation of palmitoyl-CoA to myristoyl-CoA | 1.964384e-01 | 0.707 |
| R-HSA-69091 | Polymerase switching | 1.964384e-01 | 0.707 |
| R-HSA-69109 | Leading Strand Synthesis | 1.964384e-01 | 0.707 |
| R-HSA-77285 | Beta oxidation of myristoyl-CoA to lauroyl-CoA | 1.964384e-01 | 0.707 |
| R-HSA-8984722 | Interleukin-35 Signalling | 1.964384e-01 | 0.707 |
| R-HSA-877312 | Regulation of IFNG signaling | 1.964384e-01 | 0.707 |
| R-HSA-1247673 | Erythrocytes take up oxygen and release carbon dioxide | 1.964384e-01 | 0.707 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 1.964384e-01 | 0.707 |
| R-HSA-8983711 | OAS antiviral response | 1.964384e-01 | 0.707 |
| R-HSA-72187 | mRNA 3'-end processing | 1.981922e-01 | 0.703 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 1.981922e-01 | 0.703 |
| R-HSA-68949 | Orc1 removal from chromatin | 1.981922e-01 | 0.703 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 1.981922e-01 | 0.703 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 1.981922e-01 | 0.703 |
| R-HSA-1221632 | Meiotic synapsis | 2.031402e-01 | 0.692 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 2.031402e-01 | 0.692 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 2.031402e-01 | 0.692 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 2.031402e-01 | 0.692 |
| R-HSA-9711123 | Cellular response to chemical stress | 2.032565e-01 | 0.692 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 2.073223e-01 | 0.683 |
| R-HSA-69306 | DNA Replication | 2.073223e-01 | 0.683 |
| R-HSA-170660 | Adenylate cyclase activating pathway | 2.073532e-01 | 0.683 |
| R-HSA-6788467 | IL-6-type cytokine receptor ligand interactions | 2.073532e-01 | 0.683 |
| R-HSA-1059683 | Interleukin-6 signaling | 2.073532e-01 | 0.683 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 2.081021e-01 | 0.682 |
| R-HSA-397014 | Muscle contraction | 2.129215e-01 | 0.672 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 2.129748e-01 | 0.672 |
| R-HSA-418597 | G alpha (z) signalling events | 2.130766e-01 | 0.671 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 2.130766e-01 | 0.671 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 2.180625e-01 | 0.661 |
| R-HSA-177929 | Signaling by EGFR | 2.180625e-01 | 0.661 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 2.180625e-01 | 0.661 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 2.180625e-01 | 0.661 |
| R-HSA-1433559 | Regulation of KIT signaling | 2.181204e-01 | 0.661 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 2.181204e-01 | 0.661 |
| R-HSA-391160 | Signal regulatory protein family interactions | 2.181204e-01 | 0.661 |
| R-HSA-1482798 | Acyl chain remodeling of CL | 2.181204e-01 | 0.661 |
| R-HSA-69239 | Synthesis of DNA | 2.229627e-01 | 0.652 |
| R-HSA-211000 | Gene Silencing by RNA | 2.229627e-01 | 0.652 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 2.230585e-01 | 0.652 |
| R-HSA-168249 | Innate Immune System | 2.239475e-01 | 0.650 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 2.287419e-01 | 0.641 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 2.287419e-01 | 0.641 |
| R-HSA-170670 | Adenylate cyclase inhibitory pathway | 2.287419e-01 | 0.641 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 2.287419e-01 | 0.641 |
| R-HSA-110312 | Translesion synthesis by REV1 | 2.287419e-01 | 0.641 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 2.287419e-01 | 0.641 |
| R-HSA-77352 | Beta oxidation of butanoyl-CoA to acetyl-CoA | 2.287419e-01 | 0.641 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 2.287419e-01 | 0.641 |
| R-HSA-419408 | Lysosphingolipid and LPA receptors | 2.287419e-01 | 0.641 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 2.287419e-01 | 0.641 |
| R-HSA-193639 | p75NTR signals via NF-kB | 2.287419e-01 | 0.641 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 2.301082e-01 | 0.638 |
| R-HSA-9658195 | Leishmania infection | 2.312998e-01 | 0.636 |
| R-HSA-9824443 | Parasitic Infection Pathways | 2.312998e-01 | 0.636 |
| R-HSA-180786 | Extension of Telomeres | 2.330763e-01 | 0.633 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 2.380958e-01 | 0.623 |
| R-HSA-351202 | Metabolism of polyamines | 2.380958e-01 | 0.623 |
| R-HSA-5656121 | Translesion synthesis by POLI | 2.392198e-01 | 0.621 |
| R-HSA-9603798 | Class I peroxisomal membrane protein import | 2.392198e-01 | 0.621 |
| R-HSA-5635838 | Activation of SMO | 2.392198e-01 | 0.621 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 2.392198e-01 | 0.621 |
| R-HSA-1483249 | Inositol phosphate metabolism | 2.409047e-01 | 0.618 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 2.431209e-01 | 0.614 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 2.431209e-01 | 0.614 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 2.431209e-01 | 0.614 |
| R-HSA-112043 | PLC beta mediated events | 2.431209e-01 | 0.614 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 2.431209e-01 | 0.614 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 2.481491e-01 | 0.605 |
| R-HSA-6784531 | tRNA processing in the nucleus | 2.481504e-01 | 0.605 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 2.481504e-01 | 0.605 |
| R-HSA-975110 | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | 2.495560e-01 | 0.603 |
| R-HSA-5655862 | Translesion synthesis by POLK | 2.495560e-01 | 0.603 |
| R-HSA-77288 | mitochondrial fatty acid beta-oxidation of unsaturated fatty acids | 2.495560e-01 | 0.603 |
| R-HSA-9702518 | STAT5 activation downstream of FLT3 ITD mutants | 2.495560e-01 | 0.603 |
| R-HSA-162906 | HIV Infection | 2.501937e-01 | 0.602 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 2.582189e-01 | 0.588 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 2.597524e-01 | 0.585 |
| R-HSA-3229121 | Glycogen storage diseases | 2.597524e-01 | 0.585 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 2.597524e-01 | 0.585 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 2.613926e-01 | 0.583 |
| R-HSA-418555 | G alpha (s) signalling events | 2.625565e-01 | 0.581 |
| R-HSA-1234174 | Cellular response to hypoxia | 2.632559e-01 | 0.580 |
| R-HSA-73894 | DNA Repair | 2.648552e-01 | 0.577 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 2.655441e-01 | 0.576 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 2.698109e-01 | 0.569 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 2.698109e-01 | 0.569 |
| R-HSA-164378 | PKA activation in glucagon signalling | 2.698109e-01 | 0.569 |
| R-HSA-5358508 | Mismatch Repair | 2.698109e-01 | 0.569 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 2.698109e-01 | 0.569 |
| R-HSA-163615 | PKA activation | 2.698109e-01 | 0.569 |
| R-HSA-432142 | Platelet sensitization by LDL | 2.698109e-01 | 0.569 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 2.698109e-01 | 0.569 |
| R-HSA-180292 | GAB1 signalosome | 2.698109e-01 | 0.569 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 2.698109e-01 | 0.569 |
| R-HSA-5693538 | Homology Directed Repair | 2.700682e-01 | 0.569 |
| R-HSA-449147 | Signaling by Interleukins | 2.707185e-01 | 0.567 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 2.715381e-01 | 0.566 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 2.733304e-01 | 0.563 |
| R-HSA-112040 | G-protein mediated events | 2.733304e-01 | 0.563 |
| R-HSA-9830369 | Kidney development | 2.733304e-01 | 0.563 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 2.797334e-01 | 0.553 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 2.797334e-01 | 0.553 |
| R-HSA-110320 | Translesion Synthesis by POLH | 2.797334e-01 | 0.553 |
| R-HSA-1480926 | O2/CO2 exchange in erythrocytes | 2.797334e-01 | 0.553 |
| R-HSA-1237044 | Erythrocytes take up carbon dioxide and release oxygen | 2.797334e-01 | 0.553 |
| R-HSA-449836 | Other interleukin signaling | 2.797334e-01 | 0.553 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 2.797334e-01 | 0.553 |
| R-HSA-73886 | Chromosome Maintenance | 2.811110e-01 | 0.551 |
| R-HSA-168255 | Influenza Infection | 2.866226e-01 | 0.543 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 2.884298e-01 | 0.540 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 2.884298e-01 | 0.540 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 2.884298e-01 | 0.540 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 2.895216e-01 | 0.538 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 2.895216e-01 | 0.538 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.895216e-01 | 0.538 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.895216e-01 | 0.538 |
| R-HSA-3322077 | Glycogen synthesis | 2.895216e-01 | 0.538 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 2.895216e-01 | 0.538 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 2.895216e-01 | 0.538 |
| R-HSA-373753 | Nephrin family interactions | 2.895216e-01 | 0.538 |
| R-HSA-1280218 | Adaptive Immune System | 2.913119e-01 | 0.536 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 2.934562e-01 | 0.532 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 2.934562e-01 | 0.532 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 2.934562e-01 | 0.532 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 2.934562e-01 | 0.532 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 2.984779e-01 | 0.525 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 2.987773e-01 | 0.525 |
| R-HSA-69186 | Lagging Strand Synthesis | 2.991773e-01 | 0.524 |
| R-HSA-111931 | PKA-mediated phosphorylation of CREB | 2.991773e-01 | 0.524 |
| R-HSA-9931295 | PD-L1(CD274) glycosylation and translocation to plasma membrane | 2.991773e-01 | 0.524 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 2.991773e-01 | 0.524 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 2.996009e-01 | 0.523 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 2.996009e-01 | 0.523 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 2.996009e-01 | 0.523 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 3.021458e-01 | 0.520 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 3.034940e-01 | 0.518 |
| R-HSA-9824446 | Viral Infection Pathways | 3.069113e-01 | 0.513 |
| R-HSA-114608 | Platelet degranulation | 3.070175e-01 | 0.513 |
| R-HSA-9013694 | Signaling by NOTCH4 | 3.085038e-01 | 0.511 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 3.087025e-01 | 0.510 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 3.087025e-01 | 0.510 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 3.087025e-01 | 0.510 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 3.087025e-01 | 0.510 |
| R-HSA-8852135 | Protein ubiquitination | 3.135065e-01 | 0.504 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 3.180987e-01 | 0.497 |
| R-HSA-6803529 | FGFR2 alternative splicing | 3.180987e-01 | 0.497 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 3.180987e-01 | 0.497 |
| R-HSA-9669938 | Signaling by KIT in disease | 3.180987e-01 | 0.497 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 3.260800e-01 | 0.487 |
| R-HSA-8854691 | Interleukin-20 family signaling | 3.273678e-01 | 0.485 |
| R-HSA-1369062 | ABC transporters in lipid homeostasis | 3.273678e-01 | 0.485 |
| R-HSA-5619084 | ABC transporter disorders | 3.284651e-01 | 0.484 |
| R-HSA-8957322 | Metabolism of steroids | 3.309435e-01 | 0.480 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 3.330138e-01 | 0.478 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 3.365115e-01 | 0.473 |
| R-HSA-6783589 | Interleukin-6 family signaling | 3.365115e-01 | 0.473 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 3.365115e-01 | 0.473 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 3.365115e-01 | 0.473 |
| R-HSA-429947 | Deadenylation of mRNA | 3.365115e-01 | 0.473 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 3.365115e-01 | 0.473 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 3.433350e-01 | 0.464 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 3.455315e-01 | 0.462 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 3.455315e-01 | 0.462 |
| R-HSA-1266695 | Interleukin-7 signaling | 3.455315e-01 | 0.462 |
| R-HSA-2160916 | Hyaluronan degradation | 3.455315e-01 | 0.462 |
| R-HSA-9620244 | Long-term potentiation | 3.455315e-01 | 0.462 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 3.455315e-01 | 0.462 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 3.478620e-01 | 0.459 |
| R-HSA-389948 | Co-inhibition by PD-1 | 3.509575e-01 | 0.455 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 3.531907e-01 | 0.452 |
| R-HSA-8874081 | MET activates PTK2 signaling | 3.544293e-01 | 0.450 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 3.544293e-01 | 0.450 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 3.544293e-01 | 0.450 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 3.544293e-01 | 0.450 |
| R-HSA-70635 | Urea cycle | 3.544293e-01 | 0.450 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 3.544293e-01 | 0.450 |
| R-HSA-2046105 | Linoleic acid (LA) metabolism | 3.544293e-01 | 0.450 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 3.544293e-01 | 0.450 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 3.580995e-01 | 0.446 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 3.589785e-01 | 0.445 |
| R-HSA-171306 | Packaging Of Telomere Ends | 3.632068e-01 | 0.440 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 3.632068e-01 | 0.440 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 3.632068e-01 | 0.440 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 3.632068e-01 | 0.440 |
| R-HSA-264876 | Insulin processing | 3.632068e-01 | 0.440 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 3.632068e-01 | 0.440 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 3.663755e-01 | 0.436 |
| R-HSA-8978868 | Fatty acid metabolism | 3.688536e-01 | 0.433 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 3.718654e-01 | 0.430 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 3.727428e-01 | 0.429 |
| R-HSA-5334118 | DNA methylation | 3.804068e-01 | 0.420 |
| R-HSA-392154 | Nitric oxide stimulates guanylate cyclase | 3.804068e-01 | 0.420 |
| R-HSA-156902 | Peptide chain elongation | 3.824308e-01 | 0.417 |
| R-HSA-1236974 | ER-Phagosome pathway | 3.872511e-01 | 0.412 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 3.884728e-01 | 0.411 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 3.888326e-01 | 0.410 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 3.913618e-01 | 0.407 |
| R-HSA-73884 | Base Excision Repair | 3.920549e-01 | 0.407 |
| R-HSA-202424 | Downstream TCR signaling | 3.920549e-01 | 0.407 |
| R-HSA-5663205 | Infectious disease | 3.936514e-01 | 0.405 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 3.959793e-01 | 0.402 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 3.968419e-01 | 0.401 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 3.968419e-01 | 0.401 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 3.971444e-01 | 0.401 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 3.971444e-01 | 0.401 |
| R-HSA-5694530 | Cargo concentration in the ER | 3.971444e-01 | 0.401 |
| R-HSA-186763 | Downstream signal transduction | 3.971444e-01 | 0.401 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 4.016115e-01 | 0.396 |
| R-HSA-381070 | IRE1alpha activates chaperones | 4.016115e-01 | 0.396 |
| R-HSA-388396 | GPCR downstream signalling | 4.037341e-01 | 0.394 |
| R-HSA-9937080 | Developmental Lineage of Multipotent Pancreatic Progenitor Cells | 4.053436e-01 | 0.392 |
| R-HSA-69190 | DNA strand elongation | 4.053436e-01 | 0.392 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 4.053436e-01 | 0.392 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 4.134317e-01 | 0.384 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 4.134317e-01 | 0.384 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 4.134317e-01 | 0.384 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 4.134317e-01 | 0.384 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 4.134317e-01 | 0.384 |
| R-HSA-159418 | Recycling of bile acids and salts | 4.134317e-01 | 0.384 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 4.158125e-01 | 0.381 |
| R-HSA-9837999 | Mitochondrial protein degradation | 4.158125e-01 | 0.381 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 4.176354e-01 | 0.379 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 4.205089e-01 | 0.376 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 4.205089e-01 | 0.376 |
| R-HSA-77289 | Mitochondrial Fatty Acid Beta-Oxidation | 4.205089e-01 | 0.376 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 4.214104e-01 | 0.375 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 4.214104e-01 | 0.375 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 4.214104e-01 | 0.375 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 4.214104e-01 | 0.375 |
| R-HSA-372790 | Signaling by GPCR | 4.234497e-01 | 0.373 |
| R-HSA-72764 | Eukaryotic Translation Termination | 4.251861e-01 | 0.371 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 4.251861e-01 | 0.371 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 4.252586e-01 | 0.371 |
| R-HSA-162587 | HIV Life Cycle | 4.284591e-01 | 0.368 |
| R-HSA-203615 | eNOS activation | 4.292810e-01 | 0.367 |
| R-HSA-5696400 | Dual Incision in GG-NER | 4.292810e-01 | 0.367 |
| R-HSA-2142845 | Hyaluronan metabolism | 4.292810e-01 | 0.367 |
| R-HSA-5673000 | RAF activation | 4.292810e-01 | 0.367 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 4.292810e-01 | 0.367 |
| R-HSA-5205647 | Mitophagy | 4.292810e-01 | 0.367 |
| R-HSA-9711097 | Cellular response to starvation | 4.320515e-01 | 0.364 |
| R-HSA-381042 | PERK regulates gene expression | 4.370451e-01 | 0.359 |
| R-HSA-195721 | Signaling by WNT | 4.388144e-01 | 0.358 |
| R-HSA-9006936 | Signaling by TGFB family members | 4.392117e-01 | 0.357 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 4.436959e-01 | 0.353 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 4.447040e-01 | 0.352 |
| R-HSA-9682385 | FLT3 signaling in disease | 4.447040e-01 | 0.352 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 4.447040e-01 | 0.352 |
| R-HSA-163560 | Triglyceride catabolism | 4.447040e-01 | 0.352 |
| R-HSA-111933 | Calmodulin induced events | 4.447040e-01 | 0.352 |
| R-HSA-111997 | CaM pathway | 4.447040e-01 | 0.352 |
| R-HSA-74158 | RNA Polymerase III Transcription | 4.447040e-01 | 0.352 |
| R-HSA-1296072 | Voltage gated Potassium channels | 4.522591e-01 | 0.345 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 4.522591e-01 | 0.345 |
| R-HSA-110331 | Cleavage of the damaged purine | 4.522591e-01 | 0.345 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 4.522591e-01 | 0.345 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 4.522591e-01 | 0.345 |
| R-HSA-2408557 | Selenocysteine synthesis | 4.528271e-01 | 0.344 |
| R-HSA-9020702 | Interleukin-1 signaling | 4.528271e-01 | 0.344 |
| R-HSA-1643685 | Disease | 4.567510e-01 | 0.340 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 4.573608e-01 | 0.340 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 4.597120e-01 | 0.338 |
| R-HSA-8875878 | MET promotes cell motility | 4.597120e-01 | 0.338 |
| R-HSA-73927 | Depurination | 4.597120e-01 | 0.338 |
| R-HSA-2046106 | alpha-linolenic acid (ALA) metabolism | 4.597120e-01 | 0.338 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 4.597120e-01 | 0.338 |
| R-HSA-192823 | Viral mRNA Translation | 4.618728e-01 | 0.335 |
| R-HSA-5619102 | SLC transporter disorders | 4.639931e-01 | 0.333 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 4.663630e-01 | 0.331 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 4.670639e-01 | 0.331 |
| R-HSA-71336 | Pentose phosphate pathway | 4.670639e-01 | 0.331 |
| R-HSA-201556 | Signaling by ALK | 4.670639e-01 | 0.331 |
| R-HSA-9833110 | RSV-host interactions | 4.708310e-01 | 0.327 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 4.743161e-01 | 0.324 |
| R-HSA-8982491 | Glycogen metabolism | 4.743161e-01 | 0.324 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 4.743161e-01 | 0.324 |
| R-HSA-5260271 | Diseases of Immune System | 4.743161e-01 | 0.324 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 4.743161e-01 | 0.324 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 4.751561e-01 | 0.323 |
| R-HSA-5696398 | Nucleotide Excision Repair | 4.752766e-01 | 0.323 |
| R-HSA-157118 | Signaling by NOTCH | 4.755355e-01 | 0.323 |
| R-HSA-418346 | Platelet homeostasis | 4.796997e-01 | 0.319 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 4.814012e-01 | 0.317 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 4.814702e-01 | 0.317 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 4.814702e-01 | 0.317 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 4.814702e-01 | 0.317 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 4.814702e-01 | 0.317 |
| R-HSA-9607240 | FLT3 Signaling | 4.814702e-01 | 0.317 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 4.814702e-01 | 0.317 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 4.814702e-01 | 0.317 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 4.814702e-01 | 0.317 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 4.841001e-01 | 0.315 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 4.882904e-01 | 0.311 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 4.882904e-01 | 0.311 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 4.884774e-01 | 0.311 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 4.884774e-01 | 0.311 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 4.884774e-01 | 0.311 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 4.885273e-01 | 0.311 |
| R-HSA-991365 | Activation of GABAB receptors | 4.954888e-01 | 0.305 |
| R-HSA-977444 | GABA B receptor activation | 4.954888e-01 | 0.305 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 4.954888e-01 | 0.305 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 4.954888e-01 | 0.305 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 4.954888e-01 | 0.305 |
| R-HSA-73928 | Depyrimidination | 4.954888e-01 | 0.305 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 4.954888e-01 | 0.305 |
| R-HSA-202403 | TCR signaling | 4.971624e-01 | 0.304 |
| R-HSA-9710421 | Defective pyroptosis | 5.023560e-01 | 0.299 |
| R-HSA-8854214 | TBC/RABGAPs | 5.023560e-01 | 0.299 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 5.057534e-01 | 0.296 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 5.091301e-01 | 0.293 |
| R-HSA-375280 | Amine ligand-binding receptors | 5.091301e-01 | 0.293 |
| R-HSA-69231 | Cyclin D associated events in G1 | 5.091301e-01 | 0.293 |
| R-HSA-69236 | G1 Phase | 5.091301e-01 | 0.293 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 5.100132e-01 | 0.292 |
| R-HSA-774815 | Nucleosome assembly | 5.158124e-01 | 0.288 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 5.158124e-01 | 0.288 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 5.158124e-01 | 0.288 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 5.158124e-01 | 0.288 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 5.158124e-01 | 0.288 |
| R-HSA-1489509 | DAG and IP3 signaling | 5.158124e-01 | 0.288 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 5.224042e-01 | 0.282 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 5.289066e-01 | 0.277 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 5.289066e-01 | 0.277 |
| R-HSA-2046104 | alpha-linolenic (omega3) and linoleic (omega6) acid metabolism | 5.289066e-01 | 0.277 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 5.309500e-01 | 0.275 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 5.309500e-01 | 0.275 |
| R-HSA-9007101 | Rab regulation of trafficking | 5.350641e-01 | 0.272 |
| R-HSA-389356 | Co-stimulation by CD28 | 5.353209e-01 | 0.271 |
| R-HSA-425410 | Metal ion SLC transporters | 5.353209e-01 | 0.271 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 5.391536e-01 | 0.268 |
| R-HSA-109704 | PI3K Cascade | 5.478898e-01 | 0.261 |
| R-HSA-2162123 | Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | 5.478898e-01 | 0.261 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 5.512729e-01 | 0.259 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 5.592276e-01 | 0.252 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 5.601203e-01 | 0.252 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 5.601203e-01 | 0.252 |
| R-HSA-6794361 | Neurexins and neuroligins | 5.601203e-01 | 0.252 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 5.601203e-01 | 0.252 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 5.661114e-01 | 0.247 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 5.661114e-01 | 0.247 |
| R-HSA-445355 | Smooth Muscle Contraction | 5.661114e-01 | 0.247 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 5.661114e-01 | 0.247 |
| R-HSA-69206 | G1/S Transition | 5.709712e-01 | 0.243 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 5.720214e-01 | 0.243 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 5.720214e-01 | 0.243 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 5.748353e-01 | 0.240 |
| R-HSA-3214815 | HDACs deacetylate histones | 5.778511e-01 | 0.238 |
| R-HSA-72766 | Translation | 5.803281e-01 | 0.236 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 5.836019e-01 | 0.234 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 5.836019e-01 | 0.234 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 5.836019e-01 | 0.234 |
| R-HSA-8956319 | Nucleotide catabolism | 5.862758e-01 | 0.232 |
| R-HSA-112399 | IRS-mediated signalling | 5.892746e-01 | 0.230 |
| R-HSA-6782135 | Dual incision in TC-NER | 5.948704e-01 | 0.226 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 5.948704e-01 | 0.226 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 6.003903e-01 | 0.222 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 6.003903e-01 | 0.222 |
| R-HSA-8979227 | Triglyceride metabolism | 6.003903e-01 | 0.222 |
| R-HSA-9909396 | Circadian clock | 6.011747e-01 | 0.221 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 6.058353e-01 | 0.218 |
| R-HSA-977443 | GABA receptor activation | 6.058353e-01 | 0.218 |
| R-HSA-8873719 | RAB geranylgeranylation | 6.058353e-01 | 0.218 |
| R-HSA-379724 | tRNA Aminoacylation | 6.058353e-01 | 0.218 |
| R-HSA-1227986 | Signaling by ERBB2 | 6.058353e-01 | 0.218 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 6.112065e-01 | 0.214 |
| R-HSA-445717 | Aquaporin-mediated transport | 6.112065e-01 | 0.214 |
| R-HSA-597592 | Post-translational protein modification | 6.155050e-01 | 0.211 |
| R-HSA-1268020 | Mitochondrial protein import | 6.165048e-01 | 0.210 |
| R-HSA-186797 | Signaling by PDGF | 6.165048e-01 | 0.210 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 6.184026e-01 | 0.209 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 6.192277e-01 | 0.208 |
| R-HSA-8848021 | Signaling by PTK6 | 6.217312e-01 | 0.206 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 6.217312e-01 | 0.206 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 6.227623e-01 | 0.206 |
| R-HSA-2428924 | IGF1R signaling cascade | 6.268868e-01 | 0.203 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 6.319723e-01 | 0.199 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 6.369889e-01 | 0.196 |
| R-HSA-5693606 | DNA Double Strand Break Response | 6.419374e-01 | 0.193 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 6.434406e-01 | 0.191 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 6.467992e-01 | 0.189 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 6.468187e-01 | 0.189 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 6.468187e-01 | 0.189 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 6.485026e-01 | 0.188 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 6.501327e-01 | 0.187 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 6.544820e-01 | 0.184 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 6.563835e-01 | 0.183 |
| R-HSA-204005 | COPII-mediated vesicle transport | 6.563835e-01 | 0.183 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 6.610688e-01 | 0.180 |
| R-HSA-8978934 | Metabolism of cofactors | 6.610688e-01 | 0.180 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 6.656905e-01 | 0.177 |
| R-HSA-74259 | Purine catabolism | 6.656905e-01 | 0.177 |
| R-HSA-9758941 | Gastrulation | 6.664279e-01 | 0.176 |
| R-HSA-9679191 | Potential therapeutics for SARS | 6.696129e-01 | 0.174 |
| R-HSA-5663084 | Diseases of carbohydrate metabolism | 6.702494e-01 | 0.174 |
| R-HSA-9679506 | SARS-CoV Infections | 6.747090e-01 | 0.171 |
| R-HSA-1226099 | Signaling by FGFR in disease | 6.747464e-01 | 0.171 |
| R-HSA-1236394 | Signaling by ERBB4 | 6.747464e-01 | 0.171 |
| R-HSA-1222556 | ROS and RNS production in phagocytes | 6.747464e-01 | 0.171 |
| R-HSA-446652 | Interleukin-1 family signaling | 6.759095e-01 | 0.170 |
| R-HSA-9609507 | Protein localization | 6.790211e-01 | 0.168 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 6.791824e-01 | 0.168 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 6.791824e-01 | 0.168 |
| R-HSA-73887 | Death Receptor Signaling | 6.821085e-01 | 0.166 |
| R-HSA-9020591 | Interleukin-12 signaling | 6.835582e-01 | 0.165 |
| R-HSA-392499 | Metabolism of proteins | 6.885417e-01 | 0.162 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 6.909920e-01 | 0.161 |
| R-HSA-9610379 | HCMV Late Events | 6.912258e-01 | 0.160 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 6.921323e-01 | 0.160 |
| R-HSA-6783783 | Interleukin-10 signaling | 6.921323e-01 | 0.160 |
| R-HSA-416482 | G alpha (12/13) signalling events | 6.921323e-01 | 0.160 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 6.942169e-01 | 0.159 |
| R-HSA-9659379 | Sensory processing of sound | 6.963322e-01 | 0.157 |
| R-HSA-418594 | G alpha (i) signalling events | 6.974938e-01 | 0.156 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 7.004750e-01 | 0.155 |
| R-HSA-6806834 | Signaling by MET | 7.004750e-01 | 0.155 |
| R-HSA-977225 | Amyloid fiber formation | 7.045616e-01 | 0.152 |
| R-HSA-2408522 | Selenoamino acid metabolism | 7.116659e-01 | 0.148 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 7.203605e-01 | 0.142 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 7.241769e-01 | 0.140 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 7.309664e-01 | 0.136 |
| R-HSA-72306 | tRNA processing | 7.309664e-01 | 0.136 |
| R-HSA-447115 | Interleukin-12 family signaling | 7.316550e-01 | 0.136 |
| R-HSA-70268 | Pyruvate metabolism | 7.316550e-01 | 0.136 |
| R-HSA-2029481 | FCGR activation | 7.562741e-01 | 0.121 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 7.693186e-01 | 0.114 |
| R-HSA-1296071 | Potassium Channels | 7.693186e-01 | 0.114 |
| R-HSA-74160 | Gene expression (Transcription) | 7.716673e-01 | 0.113 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 7.755778e-01 | 0.110 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 7.756281e-01 | 0.110 |
| R-HSA-3214847 | HATs acetylate histones | 7.786438e-01 | 0.109 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 7.933591e-01 | 0.101 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 7.961832e-01 | 0.099 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 7.961832e-01 | 0.099 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 8.017165e-01 | 0.096 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 8.123386e-01 | 0.090 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 8.248230e-01 | 0.084 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 8.272189e-01 | 0.082 |
| R-HSA-2980736 | Peptide hormone metabolism | 8.342125e-01 | 0.079 |
| R-HSA-8951664 | Neddylation | 8.426012e-01 | 0.074 |
| R-HSA-1474244 | Extracellular matrix organization | 8.599354e-01 | 0.066 |
| R-HSA-72312 | rRNA processing | 8.600573e-01 | 0.065 |
| R-HSA-73857 | RNA Polymerase II Transcription | 8.608201e-01 | 0.065 |
| R-HSA-3247509 | Chromatin modifying enzymes | 8.630352e-01 | 0.064 |
| R-HSA-15869 | Metabolism of nucleotides | 8.659552e-01 | 0.063 |
| R-HSA-5576891 | Cardiac conduction | 8.670184e-01 | 0.062 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 8.688394e-01 | 0.061 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 8.720203e-01 | 0.059 |
| R-HSA-212436 | Generic Transcription Pathway | 8.738019e-01 | 0.059 |
| R-HSA-4839726 | Chromatin organization | 8.835879e-01 | 0.054 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 9.004685e-01 | 0.046 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 9.031794e-01 | 0.044 |
| R-HSA-2142753 | Arachidonate metabolism | 9.031794e-01 | 0.044 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.211387e-01 | 0.036 |
| R-HSA-556833 | Metabolism of lipids | 9.269520e-01 | 0.033 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 9.305072e-01 | 0.031 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 9.450727e-01 | 0.025 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 9.458279e-01 | 0.024 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 9.528337e-01 | 0.021 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.680091e-01 | 0.014 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.684917e-01 | 0.014 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.709712e-01 | 0.013 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.781656e-01 | 0.010 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.789326e-01 | 0.009 |
| R-HSA-9734767 | Developmental Cell Lineages | 9.797730e-01 | 0.009 |
| R-HSA-1483257 | Phospholipid metabolism | 9.870440e-01 | 0.006 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.931816e-01 | 0.003 |
| R-HSA-382551 | Transport of small molecules | 9.943623e-01 | 0.002 |
| R-HSA-1430728 | Metabolism | 9.974756e-01 | 0.001 |
| R-HSA-5668914 | Diseases of metabolism | 9.979854e-01 | 0.001 |
| R-HSA-500792 | GPCR ligand binding | 9.980258e-01 | 0.001 |
| R-HSA-9709957 | Sensory Perception | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
MARK4 |
0.826 | 0.379 | 4 | 0.867 |
MARK3 |
0.824 | 0.416 | 4 | 0.903 |
AMPKA1 |
0.824 | 0.338 | -3 | 0.887 |
MARK2 |
0.823 | 0.417 | 4 | 0.877 |
QSK |
0.823 | 0.356 | 4 | 0.868 |
TSSK1 |
0.823 | 0.339 | -3 | 0.899 |
AMPKA2 |
0.822 | 0.307 | -3 | 0.869 |
SIK |
0.821 | 0.312 | -3 | 0.817 |
MARK1 |
0.817 | 0.399 | 4 | 0.880 |
BRSK1 |
0.814 | 0.268 | -3 | 0.842 |
QIK |
0.812 | 0.292 | -3 | 0.867 |
BRSK2 |
0.811 | 0.252 | -3 | 0.871 |
PRKD2 |
0.810 | 0.156 | -3 | 0.827 |
TSSK2 |
0.810 | 0.260 | -5 | 0.835 |
TBK1 |
0.810 | 0.238 | 1 | 0.710 |
NIM1 |
0.809 | 0.173 | 3 | 0.703 |
SSTK |
0.808 | 0.342 | 4 | 0.838 |
PRKD1 |
0.808 | 0.117 | -3 | 0.841 |
RAF1 |
0.807 | 0.226 | 1 | 0.718 |
BCKDK |
0.807 | 0.211 | -1 | 0.840 |
MST4 |
0.807 | 0.169 | 2 | 0.797 |
NUAK2 |
0.807 | 0.170 | -3 | 0.873 |
IKKE |
0.806 | 0.225 | 1 | 0.723 |
NDR2 |
0.805 | 0.089 | -3 | 0.847 |
MELK |
0.805 | 0.191 | -3 | 0.866 |
NDR1 |
0.804 | 0.121 | -3 | 0.859 |
CAMK1B |
0.804 | 0.144 | -3 | 0.877 |
NUAK1 |
0.804 | 0.157 | -3 | 0.851 |
PDHK1 |
0.803 | 0.194 | 1 | 0.714 |
CDC7 |
0.803 | 0.019 | 1 | 0.592 |
WNK1 |
0.802 | 0.160 | -2 | 0.895 |
RSK2 |
0.802 | 0.103 | -3 | 0.799 |
COT |
0.801 | -0.025 | 2 | 0.805 |
PKACG |
0.800 | 0.132 | -2 | 0.811 |
MAPKAPK3 |
0.800 | 0.114 | -3 | 0.827 |
WNK3 |
0.800 | 0.129 | 1 | 0.653 |
HUNK |
0.799 | 0.099 | 2 | 0.731 |
LATS2 |
0.799 | 0.085 | -5 | 0.784 |
PIM3 |
0.798 | 0.044 | -3 | 0.829 |
IKKB |
0.798 | 0.055 | -2 | 0.794 |
PDHK4 |
0.797 | 0.032 | 1 | 0.680 |
P90RSK |
0.797 | 0.075 | -3 | 0.788 |
PRKD3 |
0.797 | 0.128 | -3 | 0.802 |
PKN3 |
0.796 | 0.058 | -3 | 0.845 |
ULK2 |
0.796 | -0.041 | 2 | 0.765 |
RSK3 |
0.796 | 0.073 | -3 | 0.795 |
PKN2 |
0.795 | 0.100 | -3 | 0.876 |
MTOR |
0.795 | -0.000 | 1 | 0.615 |
P70S6KB |
0.795 | 0.100 | -3 | 0.836 |
CAMK2D |
0.795 | 0.075 | -3 | 0.866 |
PIM1 |
0.794 | 0.101 | -3 | 0.804 |
NIK |
0.794 | 0.128 | -3 | 0.890 |
MAPKAPK2 |
0.793 | 0.093 | -3 | 0.772 |
PRPK |
0.792 | -0.086 | -1 | 0.833 |
PKCD |
0.792 | 0.086 | 2 | 0.739 |
CAMK4 |
0.791 | 0.086 | -3 | 0.871 |
AURC |
0.790 | 0.090 | -2 | 0.702 |
NLK |
0.790 | -0.012 | 1 | 0.581 |
PHKG2 |
0.790 | 0.145 | -3 | 0.877 |
CAMK2G |
0.790 | -0.024 | 2 | 0.751 |
PAK6 |
0.789 | 0.113 | -2 | 0.754 |
CHK1 |
0.789 | 0.143 | -3 | 0.873 |
PKG2 |
0.789 | 0.120 | -2 | 0.753 |
GCN2 |
0.789 | -0.154 | 2 | 0.763 |
ATR |
0.789 | -0.030 | 1 | 0.601 |
CAMLCK |
0.789 | 0.054 | -2 | 0.880 |
SGK3 |
0.788 | 0.131 | -3 | 0.813 |
PKACB |
0.788 | 0.115 | -2 | 0.734 |
MNK2 |
0.787 | 0.080 | -2 | 0.840 |
AURB |
0.787 | 0.093 | -2 | 0.701 |
DAPK2 |
0.787 | 0.034 | -3 | 0.875 |
SNRK |
0.787 | 0.073 | 2 | 0.705 |
CDKL1 |
0.787 | 0.012 | -3 | 0.799 |
HIPK4 |
0.787 | 0.015 | 1 | 0.527 |
SKMLCK |
0.786 | 0.037 | -2 | 0.859 |
DSTYK |
0.786 | -0.061 | 2 | 0.797 |
PAK3 |
0.786 | 0.047 | -2 | 0.819 |
MOS |
0.786 | -0.077 | 1 | 0.598 |
NEK7 |
0.785 | -0.067 | -3 | 0.812 |
PHKG1 |
0.785 | 0.056 | -3 | 0.860 |
CAMK1G |
0.785 | 0.107 | -3 | 0.810 |
PRKX |
0.785 | 0.143 | -3 | 0.743 |
CAMK2B |
0.785 | 0.075 | 2 | 0.706 |
IKKA |
0.785 | 0.028 | -2 | 0.760 |
BMPR2 |
0.784 | -0.139 | -2 | 0.895 |
ULK1 |
0.784 | -0.081 | -3 | 0.798 |
CDKL5 |
0.784 | 0.010 | -3 | 0.794 |
CAMK1D |
0.784 | 0.150 | -3 | 0.758 |
PAK1 |
0.783 | 0.052 | -2 | 0.804 |
SRPK1 |
0.782 | 0.025 | -3 | 0.752 |
DCAMKL1 |
0.782 | 0.125 | -3 | 0.847 |
CLK3 |
0.782 | 0.006 | 1 | 0.527 |
ERK5 |
0.782 | -0.051 | 1 | 0.550 |
RSK4 |
0.782 | 0.085 | -3 | 0.762 |
DNAPK |
0.782 | 0.092 | 1 | 0.627 |
PKACA |
0.782 | 0.120 | -2 | 0.693 |
TGFBR2 |
0.782 | -0.047 | -2 | 0.760 |
RIPK3 |
0.782 | -0.063 | 3 | 0.593 |
NEK2 |
0.782 | 0.067 | 2 | 0.789 |
MNK1 |
0.782 | 0.088 | -2 | 0.856 |
CAMK2A |
0.781 | 0.075 | 2 | 0.710 |
NEK9 |
0.781 | -0.043 | 2 | 0.807 |
NEK6 |
0.781 | -0.087 | -2 | 0.860 |
MSK2 |
0.781 | 0.023 | -3 | 0.750 |
P70S6K |
0.780 | 0.087 | -3 | 0.762 |
LATS1 |
0.780 | 0.095 | -3 | 0.847 |
SRPK2 |
0.780 | 0.038 | -3 | 0.691 |
MSK1 |
0.779 | 0.056 | -3 | 0.772 |
GRK6 |
0.779 | -0.011 | 1 | 0.621 |
PIM2 |
0.779 | 0.081 | -3 | 0.792 |
MASTL |
0.779 | -0.112 | -2 | 0.851 |
MYLK4 |
0.779 | 0.072 | -2 | 0.805 |
CHAK2 |
0.779 | -0.065 | -1 | 0.809 |
ICK |
0.778 | -0.000 | -3 | 0.829 |
AKT2 |
0.778 | 0.087 | -3 | 0.737 |
PAK2 |
0.778 | 0.045 | -2 | 0.794 |
PKCB |
0.778 | 0.027 | 2 | 0.682 |
RIPK1 |
0.777 | -0.084 | 1 | 0.611 |
PKCH |
0.777 | 0.036 | 2 | 0.675 |
IRE1 |
0.777 | -0.059 | 1 | 0.569 |
WNK4 |
0.776 | 0.086 | -2 | 0.885 |
CAMK1A |
0.776 | 0.146 | -3 | 0.725 |
AKT1 |
0.776 | 0.098 | -3 | 0.765 |
GRK5 |
0.776 | -0.137 | -3 | 0.796 |
ANKRD3 |
0.775 | -0.052 | 1 | 0.662 |
PKCA |
0.775 | 0.032 | 2 | 0.683 |
PLK1 |
0.775 | -0.009 | -2 | 0.825 |
ATM |
0.775 | -0.041 | 1 | 0.564 |
IRE2 |
0.774 | -0.031 | 2 | 0.731 |
CLK1 |
0.774 | 0.056 | -3 | 0.805 |
CHAK1 |
0.774 | -0.027 | 2 | 0.787 |
PKCG |
0.774 | 0.021 | 2 | 0.674 |
MLK1 |
0.773 | -0.131 | 2 | 0.751 |
MAPKAPK5 |
0.772 | -0.021 | -3 | 0.755 |
GRK1 |
0.771 | -0.022 | -2 | 0.764 |
PKR |
0.771 | -0.012 | 1 | 0.620 |
CLK4 |
0.771 | 0.035 | -3 | 0.802 |
PAK5 |
0.771 | 0.070 | -2 | 0.674 |
DCAMKL2 |
0.771 | 0.080 | -3 | 0.873 |
YSK4 |
0.771 | 0.040 | 1 | 0.685 |
AURA |
0.771 | 0.046 | -2 | 0.650 |
DLK |
0.771 | -0.119 | 1 | 0.643 |
CDK8 |
0.770 | -0.068 | 1 | 0.420 |
SRPK3 |
0.770 | 0.013 | -3 | 0.722 |
MRCKA |
0.770 | 0.161 | -3 | 0.814 |
PKCT |
0.770 | 0.035 | 2 | 0.697 |
TTBK2 |
0.770 | -0.087 | 2 | 0.675 |
PLK4 |
0.768 | 0.011 | 2 | 0.620 |
CDK7 |
0.768 | -0.054 | 1 | 0.421 |
FAM20C |
0.768 | -0.029 | 2 | 0.473 |
BRAF |
0.767 | 0.023 | -4 | 0.698 |
PKCZ |
0.767 | -0.035 | 2 | 0.748 |
MLK2 |
0.767 | -0.137 | 2 | 0.785 |
PKN1 |
0.767 | 0.059 | -3 | 0.788 |
MRCKB |
0.767 | 0.147 | -3 | 0.803 |
PKG1 |
0.767 | 0.110 | -2 | 0.694 |
PLK3 |
0.766 | -0.021 | 2 | 0.696 |
SMG1 |
0.766 | -0.062 | 1 | 0.574 |
GRK4 |
0.766 | -0.119 | -2 | 0.803 |
VRK2 |
0.766 | -0.135 | 1 | 0.628 |
SMMLCK |
0.766 | 0.046 | -3 | 0.845 |
CDK19 |
0.766 | -0.068 | 1 | 0.390 |
DYRK2 |
0.766 | -0.043 | 1 | 0.453 |
MEK1 |
0.766 | -0.069 | 2 | 0.768 |
ALK4 |
0.766 | -0.067 | -2 | 0.797 |
PAK4 |
0.765 | 0.054 | -2 | 0.669 |
KIS |
0.765 | -0.075 | 1 | 0.443 |
IRAK4 |
0.764 | -0.027 | 1 | 0.594 |
MST3 |
0.764 | 0.076 | 2 | 0.769 |
PKCI |
0.763 | 0.030 | 2 | 0.700 |
TLK2 |
0.763 | -0.041 | 1 | 0.635 |
SGK1 |
0.763 | 0.100 | -3 | 0.655 |
JNK2 |
0.762 | -0.022 | 1 | 0.403 |
HIPK1 |
0.762 | -0.004 | 1 | 0.460 |
TGFBR1 |
0.762 | -0.062 | -2 | 0.758 |
ROCK2 |
0.762 | 0.158 | -3 | 0.834 |
MEKK1 |
0.761 | -0.045 | 1 | 0.647 |
AKT3 |
0.761 | 0.082 | -3 | 0.668 |
HRI |
0.761 | -0.089 | -2 | 0.851 |
CHK2 |
0.760 | 0.075 | -3 | 0.706 |
PKCE |
0.760 | 0.053 | 2 | 0.661 |
DAPK3 |
0.759 | 0.062 | -3 | 0.834 |
BMPR1B |
0.759 | -0.047 | 1 | 0.559 |
CDK9 |
0.759 | -0.068 | 1 | 0.414 |
DYRK1A |
0.759 | -0.019 | 1 | 0.480 |
TAO2 |
0.758 | 0.064 | 2 | 0.805 |
TAO3 |
0.758 | 0.051 | 1 | 0.650 |
SBK |
0.758 | 0.085 | -3 | 0.637 |
CDK2 |
0.758 | -0.063 | 1 | 0.447 |
HIPK3 |
0.758 | -0.029 | 1 | 0.484 |
P38A |
0.757 | -0.051 | 1 | 0.453 |
LOK |
0.757 | 0.126 | -2 | 0.849 |
CDK5 |
0.757 | -0.065 | 1 | 0.421 |
ZAK |
0.757 | -0.071 | 1 | 0.638 |
CDK13 |
0.757 | -0.086 | 1 | 0.403 |
KHS1 |
0.757 | 0.242 | 1 | 0.744 |
NEK4 |
0.757 | 0.099 | 1 | 0.682 |
DRAK1 |
0.757 | -0.099 | 1 | 0.555 |
PERK |
0.756 | -0.120 | -2 | 0.826 |
MEK5 |
0.756 | -0.106 | 2 | 0.781 |
MLK3 |
0.756 | -0.134 | 2 | 0.679 |
JNK3 |
0.756 | -0.050 | 1 | 0.415 |
HIPK2 |
0.756 | -0.029 | 1 | 0.375 |
GRK7 |
0.756 | -0.038 | 1 | 0.554 |
CLK2 |
0.756 | 0.025 | -3 | 0.779 |
TLK1 |
0.756 | -0.044 | -2 | 0.792 |
HGK |
0.756 | 0.109 | 3 | 0.702 |
IRAK1 |
0.756 | -0.076 | -1 | 0.740 |
HPK1 |
0.756 | 0.208 | 1 | 0.736 |
NEK5 |
0.755 | -0.056 | 1 | 0.628 |
GSK3B |
0.755 | -0.026 | 4 | 0.393 |
ACVR2A |
0.755 | -0.090 | -2 | 0.766 |
MINK |
0.755 | 0.156 | 1 | 0.725 |
ERK2 |
0.754 | -0.069 | 1 | 0.427 |
KHS2 |
0.754 | 0.219 | 1 | 0.747 |
ROCK1 |
0.754 | 0.144 | -3 | 0.816 |
MEKK3 |
0.754 | -0.080 | 1 | 0.659 |
TNIK |
0.754 | 0.125 | 3 | 0.713 |
CRIK |
0.754 | 0.133 | -3 | 0.746 |
MEKK2 |
0.754 | -0.057 | 2 | 0.768 |
GCK |
0.754 | 0.158 | 1 | 0.715 |
ERK1 |
0.753 | -0.064 | 1 | 0.401 |
ALK2 |
0.753 | -0.084 | -2 | 0.769 |
CDK18 |
0.753 | -0.065 | 1 | 0.353 |
DYRK1B |
0.753 | -0.027 | 1 | 0.395 |
MEKK6 |
0.753 | 0.029 | 1 | 0.635 |
P38B |
0.752 | -0.049 | 1 | 0.402 |
DMPK1 |
0.752 | 0.141 | -3 | 0.822 |
ACVR2B |
0.752 | -0.101 | -2 | 0.775 |
CDK10 |
0.751 | -0.013 | 1 | 0.382 |
PINK1 |
0.751 | -0.161 | 1 | 0.541 |
CDK12 |
0.751 | -0.081 | 1 | 0.388 |
TTBK1 |
0.751 | -0.070 | 2 | 0.600 |
CDK1 |
0.751 | -0.075 | 1 | 0.380 |
LKB1 |
0.751 | -0.023 | -3 | 0.830 |
DYRK3 |
0.750 | -0.019 | 1 | 0.470 |
DAPK1 |
0.750 | 0.031 | -3 | 0.810 |
P38G |
0.750 | -0.055 | 1 | 0.320 |
CDK17 |
0.750 | -0.068 | 1 | 0.316 |
MPSK1 |
0.750 | -0.054 | 1 | 0.533 |
CAMKK2 |
0.749 | -0.039 | -2 | 0.813 |
NEK11 |
0.749 | -0.020 | 1 | 0.665 |
PDK1 |
0.749 | -0.012 | 1 | 0.620 |
MLK4 |
0.749 | -0.168 | 2 | 0.666 |
MST2 |
0.748 | 0.059 | 1 | 0.706 |
YSK1 |
0.748 | 0.050 | 2 | 0.782 |
CAMKK1 |
0.748 | -0.087 | -2 | 0.819 |
CDK14 |
0.748 | -0.048 | 1 | 0.401 |
GAK |
0.747 | -0.033 | 1 | 0.570 |
MAP3K15 |
0.747 | 0.007 | 1 | 0.634 |
GSK3A |
0.747 | -0.035 | 4 | 0.400 |
MST1 |
0.747 | 0.106 | 1 | 0.706 |
NEK1 |
0.747 | 0.034 | 1 | 0.631 |
GRK2 |
0.747 | -0.093 | -2 | 0.690 |
CDK16 |
0.747 | -0.033 | 1 | 0.326 |
NEK8 |
0.747 | -0.093 | 2 | 0.788 |
PASK |
0.747 | -0.037 | -3 | 0.829 |
BUB1 |
0.747 | 0.052 | -5 | 0.806 |
CK2A2 |
0.745 | -0.013 | 1 | 0.475 |
RIPK2 |
0.745 | -0.077 | 1 | 0.638 |
CDK3 |
0.745 | -0.051 | 1 | 0.327 |
CK1G1 |
0.745 | -0.031 | -3 | 0.425 |
BMPR1A |
0.744 | -0.058 | 1 | 0.542 |
NEK3 |
0.744 | -0.017 | 1 | 0.618 |
DYRK4 |
0.744 | -0.054 | 1 | 0.387 |
PBK |
0.744 | -0.002 | 1 | 0.513 |
LRRK2 |
0.744 | -0.028 | 2 | 0.812 |
TAK1 |
0.743 | 0.034 | 1 | 0.691 |
PRP4 |
0.742 | -0.087 | -3 | 0.694 |
SLK |
0.741 | 0.043 | -2 | 0.772 |
MOK |
0.741 | 0.009 | 1 | 0.462 |
EEF2K |
0.741 | -0.056 | 3 | 0.707 |
P38D |
0.739 | -0.057 | 1 | 0.334 |
CDK4 |
0.739 | -0.055 | 1 | 0.376 |
MEK2 |
0.738 | -0.071 | 2 | 0.779 |
CDK6 |
0.737 | -0.059 | 1 | 0.383 |
CK1E |
0.736 | -0.092 | -3 | 0.441 |
TAO1 |
0.736 | 0.057 | 1 | 0.639 |
VRK1 |
0.735 | -0.132 | 2 | 0.795 |
STK33 |
0.734 | -0.102 | 2 | 0.578 |
ERK7 |
0.734 | -0.049 | 2 | 0.503 |
CK2A1 |
0.733 | -0.039 | 1 | 0.462 |
MAK |
0.732 | -0.013 | -2 | 0.681 |
PLK2 |
0.732 | -0.049 | -3 | 0.720 |
JNK1 |
0.730 | -0.070 | 1 | 0.371 |
CK1A2 |
0.730 | -0.069 | -3 | 0.395 |
GRK3 |
0.730 | -0.097 | -2 | 0.627 |
CK1D |
0.727 | -0.083 | -3 | 0.389 |
PDHK3_TYR |
0.726 | 0.061 | 4 | 0.705 |
MYO3B |
0.726 | -0.010 | 2 | 0.794 |
MYO3A |
0.723 | 0.027 | 1 | 0.669 |
ASK1 |
0.723 | -0.034 | 1 | 0.624 |
BIKE |
0.723 | -0.040 | 1 | 0.466 |
TESK1_TYR |
0.722 | 0.001 | 3 | 0.751 |
HASPIN |
0.720 | -0.042 | -1 | 0.657 |
LIMK2_TYR |
0.719 | 0.034 | -3 | 0.892 |
TYK2 |
0.719 | 0.037 | 1 | 0.649 |
MAP2K7_TYR |
0.719 | -0.013 | 2 | 0.817 |
PKMYT1_TYR |
0.718 | -0.076 | 3 | 0.709 |
NEK10_TYR |
0.718 | 0.114 | 1 | 0.592 |
OSR1 |
0.717 | -0.094 | 2 | 0.759 |
TTK |
0.717 | -0.081 | -2 | 0.799 |
RET |
0.717 | 0.032 | 1 | 0.638 |
PINK1_TYR |
0.716 | -0.101 | 1 | 0.604 |
DDR1 |
0.715 | -0.009 | 4 | 0.693 |
PDHK4_TYR |
0.714 | -0.033 | 2 | 0.826 |
TNNI3K_TYR |
0.714 | 0.029 | 1 | 0.622 |
LIMK1_TYR |
0.714 | -0.055 | 2 | 0.827 |
MAP2K4_TYR |
0.713 | -0.131 | -1 | 0.856 |
STLK3 |
0.712 | -0.055 | 1 | 0.643 |
ROS1 |
0.712 | -0.024 | 3 | 0.632 |
BMPR2_TYR |
0.710 | -0.056 | -1 | 0.847 |
JAK2 |
0.710 | -0.027 | 1 | 0.644 |
MST1R |
0.709 | -0.047 | 3 | 0.659 |
MAP2K6_TYR |
0.709 | -0.148 | -1 | 0.865 |
AAK1 |
0.709 | -0.022 | 1 | 0.378 |
JAK1 |
0.709 | 0.042 | 1 | 0.649 |
EPHA6 |
0.707 | -0.059 | -1 | 0.828 |
TNK1 |
0.706 | -0.010 | 3 | 0.641 |
TYRO3 |
0.705 | -0.115 | 3 | 0.659 |
PDHK1_TYR |
0.704 | -0.139 | -1 | 0.864 |
YANK3 |
0.703 | -0.086 | 2 | 0.356 |
PDGFRB |
0.702 | -0.096 | 3 | 0.657 |
JAK3 |
0.701 | -0.100 | 1 | 0.602 |
DDR2 |
0.699 | -0.000 | 3 | 0.599 |
EPHB4 |
0.699 | -0.129 | -1 | 0.813 |
ALPHAK3 |
0.699 | -0.126 | -1 | 0.731 |
CSF1R |
0.699 | -0.113 | 3 | 0.628 |
PDGFRA |
0.699 | -0.089 | 3 | 0.651 |
FLT3 |
0.698 | -0.091 | 3 | 0.649 |
INSRR |
0.698 | -0.089 | 3 | 0.618 |
FGFR1 |
0.698 | -0.079 | 3 | 0.638 |
TNK2 |
0.696 | -0.111 | 3 | 0.608 |
ALK |
0.696 | -0.078 | 3 | 0.590 |
ABL2 |
0.695 | -0.121 | -1 | 0.780 |
AXL |
0.694 | -0.100 | 3 | 0.630 |
FGFR2 |
0.694 | -0.113 | 3 | 0.660 |
FGR |
0.694 | -0.167 | 1 | 0.609 |
EPHB1 |
0.694 | -0.128 | 1 | 0.636 |
LTK |
0.693 | -0.088 | 3 | 0.603 |
FER |
0.693 | -0.192 | 1 | 0.619 |
YES1 |
0.693 | -0.145 | -1 | 0.818 |
KDR |
0.692 | -0.089 | 3 | 0.605 |
ABL1 |
0.692 | -0.121 | -1 | 0.774 |
TEK |
0.691 | -0.108 | 3 | 0.600 |
CK1A |
0.690 | -0.109 | -3 | 0.293 |
EPHB3 |
0.690 | -0.143 | -1 | 0.801 |
HCK |
0.689 | -0.162 | -1 | 0.791 |
EPHA4 |
0.688 | -0.128 | 2 | 0.679 |
BTK |
0.688 | -0.164 | -1 | 0.724 |
NTRK2 |
0.687 | -0.144 | 3 | 0.606 |
EPHB2 |
0.687 | -0.144 | -1 | 0.793 |
WEE1_TYR |
0.687 | -0.111 | -1 | 0.707 |
EPHA1 |
0.687 | -0.102 | 3 | 0.608 |
SRMS |
0.687 | -0.185 | 1 | 0.625 |
PTK6 |
0.687 | -0.149 | -1 | 0.699 |
INSR |
0.686 | -0.126 | 3 | 0.594 |
TXK |
0.686 | -0.134 | 1 | 0.585 |
ITK |
0.686 | -0.172 | -1 | 0.764 |
NTRK1 |
0.685 | -0.169 | -1 | 0.806 |
TEC |
0.685 | -0.122 | -1 | 0.688 |
KIT |
0.685 | -0.164 | 3 | 0.633 |
LCK |
0.684 | -0.140 | -1 | 0.793 |
CK1G3 |
0.684 | -0.047 | -3 | 0.245 |
MERTK |
0.684 | -0.157 | 3 | 0.630 |
EPHA3 |
0.682 | -0.133 | 2 | 0.677 |
FLT4 |
0.682 | -0.139 | 3 | 0.600 |
BLK |
0.681 | -0.129 | -1 | 0.801 |
ERBB2 |
0.681 | -0.140 | 1 | 0.597 |
EPHA7 |
0.681 | -0.132 | 2 | 0.695 |
MET |
0.680 | -0.170 | 3 | 0.631 |
FGFR3 |
0.680 | -0.136 | 3 | 0.635 |
FRK |
0.680 | -0.129 | -1 | 0.790 |
BMX |
0.679 | -0.144 | -1 | 0.665 |
NTRK3 |
0.676 | -0.171 | -1 | 0.757 |
FLT1 |
0.676 | -0.154 | -1 | 0.806 |
PTK2B |
0.675 | -0.139 | -1 | 0.746 |
MUSK |
0.673 | -0.128 | 1 | 0.502 |
LYN |
0.672 | -0.175 | 3 | 0.571 |
EPHA5 |
0.671 | -0.151 | 2 | 0.670 |
FYN |
0.671 | -0.144 | -1 | 0.769 |
EGFR |
0.671 | -0.117 | 1 | 0.513 |
CSK |
0.670 | -0.148 | 2 | 0.710 |
MATK |
0.669 | -0.153 | -1 | 0.708 |
YANK2 |
0.668 | -0.102 | 2 | 0.359 |
EPHA8 |
0.667 | -0.158 | -1 | 0.777 |
IGF1R |
0.667 | -0.137 | 3 | 0.549 |
SRC |
0.664 | -0.180 | -1 | 0.770 |
FGFR4 |
0.662 | -0.138 | -1 | 0.738 |
PTK2 |
0.660 | -0.098 | -1 | 0.766 |
EPHA2 |
0.657 | -0.160 | -1 | 0.738 |
SYK |
0.655 | -0.129 | -1 | 0.739 |
ERBB4 |
0.653 | -0.134 | 1 | 0.521 |
FES |
0.649 | -0.174 | -1 | 0.651 |
CK1G2 |
0.646 | -0.107 | -3 | 0.344 |
ZAP70 |
0.626 | -0.146 | -1 | 0.665 |