Motif 821 (n=135)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0B4J269 | None | S462 | ochoa | Melanocyte-stimulating hormone receptor (Melanocortin receptor 1) | Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes. {ECO:0000256|ARBA:ARBA00023428}. |
| O43663 | PRC1 | S267 | ochoa | Protein regulator of cytokinesis 1 | Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436). {ECO:0000269|PubMed:12082078, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:17409436, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:20691902, ECO:0000269|PubMed:9885575}. |
| O43684 | BUB3 | S135 | psp | Mitotic checkpoint protein BUB3 | Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:18199686}. |
| O60763 | USO1 | S880 | ochoa | General vesicular transport factor p115 (Protein USO1 homolog) (Transcytosis-associated protein) (TAP) (Vesicle-docking protein) | General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity. {ECO:0000250|UniProtKB:P41542}. |
| O95238 | SPDEF | S243 | psp | SAM pointed domain-containing Ets transcription factor (Prostate epithelium-specific Ets transcription factor) (Prostate-specific Ets) (Prostate-derived Ets factor) | May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT-3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter. {ECO:0000269|PubMed:10625666}. |
| O95613 | PCNT | S455 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| P05783 | KRT18 | S312 | ochoa | Keratin, type I cytoskeletal 18 (Cell proliferation-inducing gene 46 protein) (Cytokeratin-18) (CK-18) (Keratin-18) (K18) | Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. {ECO:0000250, ECO:0000269|PubMed:15529338, ECO:0000269|PubMed:16424149, ECO:0000269|PubMed:17213200, ECO:0000269|PubMed:7523419, ECO:0000269|PubMed:8522591, ECO:0000269|PubMed:9298992, ECO:0000269|PubMed:9524113}. |
| P07101 | TH | S502 | ochoa | Tyrosine 3-monooxygenase (EC 1.14.16.2) (Tyrosine 3-hydroxylase) (TH) | Catalyzes the conversion of L-tyrosine to L-dihydroxyphenylalanine (L-Dopa), the rate-limiting step in the biosynthesis of catecholamines, dopamine, noradrenaline, and adrenaline. Uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to L-Dopa (PubMed:15287903, PubMed:1680128, PubMed:17391063, PubMed:24753243, PubMed:34922205, PubMed:8528210, Ref.18). In addition to tyrosine, is able to catalyze the hydroxylation of phenylalanine and tryptophan with lower specificity (By similarity). Positively regulates the regression of retinal hyaloid vessels during postnatal development (By similarity). {ECO:0000250|UniProtKB:P04177, ECO:0000250|UniProtKB:P24529, ECO:0000269|PubMed:15287903, ECO:0000269|PubMed:1680128, ECO:0000269|PubMed:17391063, ECO:0000269|PubMed:24753243, ECO:0000269|PubMed:34922205, ECO:0000269|PubMed:8528210, ECO:0000269|Ref.18}.; FUNCTION: [Isoform 5]: Lacks catalytic activity. {ECO:0000269|PubMed:17391063}.; FUNCTION: [Isoform 6]: Lacks catalytic activity. {ECO:0000269|PubMed:17391063}. |
| P07237 | P4HB | S190 | ochoa | Protein disulfide-isomerase (PDI) (EC 5.3.4.1) (Cellular thyroid hormone-binding protein) (Prolyl 4-hydroxylase subunit beta) (p55) | This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations and following phosphorylation by FAM20C, functions as a chaperone that inhibits aggregation of misfolded proteins (PubMed:32149426). At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts as a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307). {ECO:0000269|PubMed:10636893, ECO:0000269|PubMed:12485997, ECO:0000269|PubMed:21670307, ECO:0000269|PubMed:32149426}. |
| P07437 | TUBB | S115 | ochoa | Tubulin beta chain (Tubulin beta-5 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P07814 | EPRS1 | S910 | ochoa | Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)] | Multifunctional protein which primarily functions within the aminoacyl-tRNA synthetase multienzyme complex, also known as multisynthetase complex. Within the complex it catalyzes the attachment of both L-glutamate and L-proline to their cognate tRNAs in a two-step reaction where the amino acid is first activated by ATP to form a covalent intermediate with AMP. Subsequently, the activated amino acid is transferred to the acceptor end of the cognate tRNA to form L-glutamyl-tRNA(Glu) and L-prolyl-tRNA(Pro) (PubMed:23263184, PubMed:24100331, PubMed:29576217, PubMed:3290852, PubMed:37212275). Upon interferon-gamma stimulation, EPRS1 undergoes phosphorylation, causing its dissociation from the aminoacyl-tRNA synthetase multienzyme complex. It is recruited to form the GAIT complex, which binds to stem loop-containing GAIT elements found in the 3'-UTR of various inflammatory mRNAs, such as ceruloplasmin. The GAIT complex inhibits the translation of these mRNAs, allowing interferon-gamma to redirect the function of EPRS1 from protein synthesis to translation inhibition in specific cell contexts (PubMed:15479637, PubMed:23071094). Furthermore, it can function as a downstream effector in the mTORC1 signaling pathway, by promoting the translocation of SLC27A1 from the cytoplasm to the plasma membrane where it mediates the uptake of long-chain fatty acid by adipocytes. Thereby, EPRS1 also plays a role in fat metabolism and more indirectly influences lifespan (PubMed:28178239). {ECO:0000269|PubMed:15479637, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:28178239, ECO:0000269|PubMed:29576217, ECO:0000269|PubMed:3290852, ECO:0000269|PubMed:37212275}. |
| P08670 | VIM | S205 | ochoa | Vimentin | Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Plays a role in cell directional movement, orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Protects SCRIB from proteasomal degradation and facilitates its localization to intermediate filaments in a cell contact-mediated manner (By similarity). {ECO:0000250|UniProtKB:A0A8C0N8E3, ECO:0000250|UniProtKB:P31000}.; FUNCTION: Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. {ECO:0000269|PubMed:21746880}. |
| P08670 | VIM | S325 | ochoa | Vimentin | Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Plays a role in cell directional movement, orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Protects SCRIB from proteasomal degradation and facilitates its localization to intermediate filaments in a cell contact-mediated manner (By similarity). {ECO:0000250|UniProtKB:A0A8C0N8E3, ECO:0000250|UniProtKB:P31000}.; FUNCTION: Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. {ECO:0000269|PubMed:21746880}. |
| P12882 | MYH1 | T1023 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12883 | MYH7 | T1019 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P12883 | MYH7 | S1518 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P13535 | MYH8 | S1725 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
| P14136 | GFAP | S323 | ochoa | Glial fibrillary acidic protein (GFAP) | GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells. |
| P15924 | DSP | S227 | ochoa | Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) | Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). {ECO:0000250|UniProtKB:F1LMV6}. |
| P15924 | DSP | S957 | ochoa | Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) | Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). {ECO:0000250|UniProtKB:F1LMV6}. |
| P16066 | NPR1 | S505 | psp | Atrial natriuretic peptide receptor 1 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type A) (ANP-A) (ANPR-A) (NPR-A) (Guanylate cyclase A) (GC-A) | Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis (PubMed:39543315). Plays an essential role in the regulation of endothelial cell senescence and vascular aging (PubMed:36016499). Upon activation by ANP or BNP, stimulates the production of cyclic guanosine monophosphate (cGMP) that promotes vascular tone and volume homeostasis by activation of protein kinase cGMP-dependent 1/PRKG1 and subsequently PRKAA1, thereby controlling blood pressure and maintaining cardiovascular homeostasis (PubMed:36016499). {ECO:0000269|PubMed:1672777, ECO:0000269|PubMed:36016499, ECO:0000269|PubMed:39543315}. |
| P17661 | DES | S330 | ochoa | Desmin | Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity (PubMed:25358400). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed:24200904, PubMed:25394388, PubMed:26724190). May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Required for nuclear membrane integrity, via anchoring at the cell tip and nuclear envelope, resulting in maintenance of microtubule-derived intracellular mechanical forces (By similarity). Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin (By similarity). {ECO:0000250|UniProtKB:P31001, ECO:0000269|PubMed:24200904, ECO:0000269|PubMed:25394388, ECO:0000269|PubMed:26724190, ECO:0000303|PubMed:25358400}. |
| P19429 | TNNI3 | S39 | psp | Troponin I, cardiac muscle (Cardiac troponin I) | Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. |
| P20700 | LMNB1 | S158 | ochoa | Lamin-B1 | Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:28716252, PubMed:32910914). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:28716252, PubMed:32910914). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:28716252, PubMed:32910914). {ECO:0000269|PubMed:28716252, ECO:0000269|PubMed:32910914}. |
| P20929 | NEB | S367 | ochoa | Nebulin | This giant muscle protein may be involved in maintaining the structural integrity of sarcomeres and the membrane system associated with the myofibrils. Binds and stabilize F-actin. |
| P29692 | EEF1D | S86 | ochoa | Elongation factor 1-delta (EF-1-delta) (Antigen NY-CO-4) | [Isoform 1]: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1-alpha for another round of transfer of aminoacyl-tRNAs to the ribosome.; FUNCTION: [Isoform 2]: Regulates induction of heat-shock-responsive genes through association with heat shock transcription factors and direct DNA-binding at heat shock promoter elements (HSE). |
| P30622 | CLIP1 | S1268 | ochoa | CAP-Gly domain-containing linker protein 1 (Cytoplasmic linker protein 1) (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed-Sternberg intermediate filament-associated protein) (Restin) | Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. {ECO:0000269|PubMed:12433698, ECO:0000269|PubMed:17563362, ECO:0000269|PubMed:17889670}. |
| P35579 | MYH9 | S1017 | ochoa | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P35579 | MYH9 | S1122 | ochoa | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P35749 | MYH11 | S1719 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
| P36873 | PPP1CC | S129 | ochoa | Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC 3.1.3.16) (Protein phosphatase 1C catalytic subunit) | Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets (PubMed:17936702, PubMed:25012651). Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1 (PubMed:17936702). Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (PubMed:20516061). In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation (PubMed:21712997). May dephosphorylate CSNK1D and CSNK1E (By similarity). Regulates the recruitment of the SKA complex to kinetochores (PubMed:28982702). Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Together with PPP1CA (PP1-alpha subunit), dephosphorylates IFIH1/MDA5 and RIG-I leading to their activation and a functional innate immune response (PubMed:23499489). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (PubMed:35768504, PubMed:35831509). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (PubMed:35768504, PubMed:35831509). Dephosphorylates MKI67 at the onset of anaphase (PubMed:25012651). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (PubMed:35768504, PubMed:35831509). {ECO:0000250|UniProtKB:P63087, ECO:0000269|PubMed:17936702, ECO:0000269|PubMed:20516061, ECO:0000269|PubMed:21712997, ECO:0000269|PubMed:23396208, ECO:0000269|PubMed:23499489, ECO:0000269|PubMed:25012651, ECO:0000269|PubMed:28982702, ECO:0000269|PubMed:35768504, ECO:0000269|PubMed:35831509}. |
| P46939 | UTRN | S1865 | ochoa | Utrophin (Dystrophin-related protein 1) (DRP-1) | May play a role in anchoring the cytoskeleton to the plasma membrane. {ECO:0000250}. |
| P46940 | IQGAP1 | S330 | ochoa | Ras GTPase-activating-like protein IQGAP1 (p195) | Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Recruited to the cell cortex by interaction with ILK which allows it to cooperate with its effector DIAPH1 to locally stabilize microtubules and allow stable insertion of caveolae into the plasma membrane (By similarity). Binds to activated CDC42 but does not stimulate its GTPase activity. Associates with calmodulin. May promote neurite outgrowth (PubMed:15695813). May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest (PubMed:20883816). {ECO:0000250|UniProtKB:Q9JKF1, ECO:0000269|PubMed:15695813, ECO:0000269|PubMed:20883816}. |
| P49591 | SARS1 | S101 | psp | Serine--tRNA ligase, cytoplasmic (EC 6.1.1.11) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase) | Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser) (PubMed:22353712, PubMed:24095058, PubMed:26433229, PubMed:28236339, PubMed:34570399, PubMed:36041817, PubMed:9431993). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (PubMed:26433229, PubMed:28236339, PubMed:34570399, PubMed:9431993). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC (PubMed:24940000). Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA (PubMed:19423847, PubMed:19423848, PubMed:24940000). {ECO:0000269|PubMed:19423847, ECO:0000269|PubMed:19423848, ECO:0000269|PubMed:22353712, ECO:0000269|PubMed:24095058, ECO:0000269|PubMed:24940000, ECO:0000269|PubMed:26433229, ECO:0000269|PubMed:28236339, ECO:0000269|PubMed:34570399, ECO:0000269|PubMed:36041817, ECO:0000269|PubMed:9431993}. |
| P62136 | PPP1CA | S129 | ochoa | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16) | Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets (PubMed:28216226, PubMed:30158517, PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670, PubMed:39603239, PubMed:39603240). Protein phosphatase 1 (PP1) is essential for cell division, transcription elongation, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670, PubMed:39603239, PubMed:39603240). Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Catalytic component of the PNUTS-PP1 protein phosphatase complex, a protein phosphatase 1 (PP1) complex that promotes RNA polymerase II transcription pause-release, allowing transcription elongation: the PNUTS-PP1 complex mediates the release of RNA polymerase II from promoter-proximal region of genes by catalyzing dephosphorylation of proteins involved in transcription, such as AFF4, CDK9, MEPCE, INTS12, NCBP1, POLR2M/GDOWN1 and SUPT6H (PubMed:39603239, PubMed:39603240). The PNUTS-PP1 complex also regulates transcription termination by mediating dephosphorylation of SUPT5H in termination zones downstream of poly(A) sites, thereby promoting deceleration of RNA polymerase II transcription (PubMed:31677974). PNUTS-PP1 complex is also involved in the response to replication stress by mediating dephosphorylation of POLR2A at 'Ser-5' of the CTD, promoting RNA polymerase II degradation (PubMed:33264625). PNUTS-PP1 also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (PubMed:20516061). Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage (PubMed:17283141). Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development (By similarity). In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation (PubMed:21712997). May dephosphorylate CSNK1D and CSNK1E (PubMed:21712997). Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Dephosphorylates CENPA (PubMed:25556658). Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy (PubMed:26083323). Together with PPP1CC (PP1-gamma subunit), dephosphorylates IFIH1/MDA5 and RIG-I leading to their activation and a functional innate immune response (PubMed:23499489). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (PubMed:35768504, PubMed:36175670). {ECO:0000250|UniProtKB:P62137, ECO:0000269|PubMed:17283141, ECO:0000269|PubMed:20516061, ECO:0000269|PubMed:21712997, ECO:0000269|PubMed:23396208, ECO:0000269|PubMed:23499489, ECO:0000269|PubMed:25556658, ECO:0000269|PubMed:26083323, ECO:0000269|PubMed:28216226, ECO:0000269|PubMed:30158517, ECO:0000269|PubMed:31677974, ECO:0000269|PubMed:33264625, ECO:0000269|PubMed:35768504, ECO:0000269|PubMed:35830882, ECO:0000269|PubMed:35831509, ECO:0000269|PubMed:36175670, ECO:0000269|PubMed:39603239, ECO:0000269|PubMed:39603240}.; FUNCTION: (Microbial infection) Necessary for alphaviruses replication. {ECO:0000269|PubMed:29769351}. |
| P62140 | PPP1CB | S128 | ochoa | Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (PPP1CD) (EC 3.1.3.16) (EC 3.1.3.53) | Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (PubMed:35768504, PubMed:35831509, PubMed:36175670). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (PubMed:35768504, PubMed:35831509, PubMed:36175670). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (PubMed:35768504, PubMed:36175670). {ECO:0000269|PubMed:20516061, ECO:0000269|PubMed:21712997, ECO:0000269|PubMed:23396208, ECO:0000269|PubMed:35768504, ECO:0000269|PubMed:35831509, ECO:0000269|PubMed:36175670}. |
| P68371 | TUBB4B | S115 | ochoa | Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q08378 | GOLGA3 | S465 | ochoa | Golgin subfamily A member 3 (Golgi complex-associated protein of 170 kDa) (GCP170) (Golgin-160) | Golgi auto-antigen; probably involved in maintaining Golgi structure. |
| Q0VF96 | CGNL1 | S1121 | ochoa | Cingulin-like protein 1 (Junction-associated coiled-coil protein) (Paracingulin) | May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons. {ECO:0000269|PubMed:22891260}. |
| Q12846 | STX4 | S78 | psp | Syntaxin-4 (Renal carcinoma antigen NY-REN-31) | Plasma membrane t-SNARE that mediates docking of transport vesicles (By similarity). Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane (By similarity). In neurons, recruited at neurite tips to membrane domains rich in the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) which promotes neurite tip surface expression of the dopamine transporter SLC6A3/DAT by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane (By similarity). Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes and in docking of synaptic vesicles at presynaptic active zones (By similarity). Required for normal hearing (PubMed:36355422). {ECO:0000250|UniProtKB:P70452, ECO:0000250|UniProtKB:Q08850, ECO:0000269|PubMed:36355422}. |
| Q13114 | TRAF3 | S349 | psp | TNF receptor-associated factor 3 (EC 2.3.2.27) (CD40 receptor-associated factor 1) (CRAF1) (CD40-binding protein) (CD40BP) (LMP1-associated protein 1) (LAP1) (RING-type E3 ubiquitin transferase TRAF3) | Cytoplasmic E3 ubiquitin ligase that regulates various signaling pathways, such as the NF-kappa-B, mitogen-activated protein kinase (MAPK) and interferon regulatory factor (IRF) pathways, and thus controls a lot of biological processes in both immune and non-immune cell types (PubMed:33148796, PubMed:33608556). In TLR and RLR signaling pathways, acts as an E3 ubiquitin ligase promoting the synthesis of 'Lys-63'-linked polyubiquitin chains on several substrates such as ASC that lead to the activation of the type I interferon response or the inflammasome (PubMed:25847972, PubMed:27980081). Following the activation of certain TLRs such as TLR4, acts as a negative NF-kappa-B regulator, possibly to avoid unregulated inflammatory response, and its degradation via 'Lys-48'-linked polyubiquitination is required for MAPK activation and production of inflammatory cytokines. Alternatively, when TLR4 orchestrates bacterial expulsion, TRAF3 undergoes 'Lys-33'-linked polyubiquitination and subsequently binds to RALGDS, mobilizing the exocyst complex to rapidly expel intracellular bacteria back for clearance (PubMed:27438768). Also acts as a constitutive negative regulator of the alternative NF-kappa-B pathway, which controls B-cell survival and lymphoid organ development. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14. {ECO:0000269|PubMed:15084608, ECO:0000269|PubMed:15383523, ECO:0000269|PubMed:17991829, ECO:0000269|PubMed:19937093, ECO:0000269|PubMed:20097753, ECO:0000269|PubMed:20185819, ECO:0000269|PubMed:25847972, ECO:0000269|PubMed:27980081, ECO:0000269|PubMed:32562145, ECO:0000269|PubMed:33148796, ECO:0000269|PubMed:33608556, ECO:0000269|PubMed:34011520}. |
| Q13416 | ORC2 | S282 | ochoa | Origin recognition complex subunit 2 | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3. {ECO:0000269|PubMed:22427655, ECO:0000269|PubMed:22935713}. |
| Q13509 | TUBB3 | S115 | ochoa | Tubulin beta-3 chain (Tubulin beta-4 chain) (Tubulin beta-III) | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:34996871, PubMed:38305685, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:34996871, PubMed:38305685, PubMed:38609661). Below the cap, alpha-beta tubulin heterodimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). TUBB3 plays a critical role in proper axon guidance and maintenance (PubMed:20074521). Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Plays a role in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). {ECO:0000269|PubMed:20074521, ECO:0000269|PubMed:28483977, ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| Q13885 | TUBB2A | S115 | ochoa | Tubulin beta-2A chain (Tubulin beta class IIa) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q14203 | DCTN1 | S320 | ochoa | Dynactin subunit 1 (150 kDa dynein-associated polypeptide) (DAP-150) (DP-150) (p135) (p150-glued) | Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule (PubMed:25185702). Can regulate microtubule stability by promoting microtubule formation, nucleation and polymerization and by inhibiting microtubule catastrophe in neurons. Inhibits microtubule catastrophe by binding both to microtubules and to tubulin, leading to enhanced microtubule stability along the axon (PubMed:23874158). Plays a role in metaphase spindle orientation (PubMed:22327364). Plays a role in centriole cohesion and subdistal appendage organization and function. Its recruitment to the centriole in a KIF3A-dependent manner is essential for the maintenance of centriole cohesion and the formation of subdistal appendage. Also required for microtubule anchoring at the mother centriole (PubMed:23386061). Plays a role in primary cilia formation (PubMed:25774020). {ECO:0000250|UniProtKB:A0A287B8J2, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23386061, ECO:0000269|PubMed:23874158, ECO:0000269|PubMed:25185702, ECO:0000269|PubMed:25774020}. |
| Q14258 | TRIM25 | S340 | ochoa | E3 ubiquitin/ISG15 ligase TRIM25 (EC 6.3.2.n3) (Estrogen-responsive finger protein) (RING finger protein 147) (RING-type E3 ubiquitin transferase) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM25) (Tripartite motif-containing protein 25) (Ubiquitin/ISG15-conjugating enzyme TRIM25) (Zinc finger protein 147) | Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase (PubMed:16352599). Involved in innate immune defense against viruses by mediating ubiquitination of RIGI and IFIH1 (PubMed:17392790, PubMed:29357390, PubMed:30193849, PubMed:31710640, PubMed:33849980, PubMed:36045682). Mediates 'Lys-63'-linked polyubiquitination of the RIGI N-terminal CARD-like region and may play a role in signal transduction that leads to the production of interferons in response to viral infection (PubMed:17392790, PubMed:23950712). Mediates 'Lys-63'-linked polyubiquitination of IFIH1 (PubMed:30193849). Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway (PubMed:16352599, PubMed:17069755). Mediates estrogen action in various target organs (PubMed:22452784). Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3 (PubMed:22452784). Plays a role in promoting the restart of stalled replication forks via interaction with the KHDC3L-OOEP scaffold and subsequent ubiquitination of BLM, resulting in the recruitment and retainment of BLM at DNA replication forks (By similarity). Plays an essential role in the antiviral activity of ZAP/ZC3HAV1; an antiviral protein which inhibits the replication of certain viruses. Mechanistically, mediates 'Lys-63'-linked polyubiquitination of ZAP/ZC3HAV1 that is required for its optimal binding to target mRNA (PubMed:28060952, PubMed:28202764). Also mediates the ubiquitination of various substrates implicated in stress granule formation, nonsense-mediated mRNA decay, nucleoside synthesis and mRNA translation and stability (PubMed:36067236). {ECO:0000250|UniProtKB:Q61510, ECO:0000269|PubMed:16352599, ECO:0000269|PubMed:17069755, ECO:0000269|PubMed:17392790, ECO:0000269|PubMed:22452784, ECO:0000269|PubMed:23950712, ECO:0000269|PubMed:29357390, ECO:0000269|PubMed:30193849, ECO:0000269|PubMed:31710640, ECO:0000269|PubMed:33849980, ECO:0000269|PubMed:36045682, ECO:0000269|PubMed:36067236}. |
| Q14789 | GOLGB1 | S2878 | ochoa | Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) | May participate in forming intercisternal cross-bridges of the Golgi complex. |
| Q15058 | KIF14 | S173 | ochoa | Kinesin-like protein KIF14 | Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis (PubMed:16648480, PubMed:24784001). During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively (PubMed:16431929). Regulates cell growth through regulation of cell cycle progression and cytokinesis (PubMed:24854087). During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic process which controls CDKN1B degradation, resulting in positive regulation of cyclins, including CCNE1, CCND1 and CCNB1 (PubMed:24854087). During late neurogenesis, regulates the cerebellar, cerebral cortex and olfactory bulb development through regulation of apoptosis, cell proliferation and cell division (By similarity). Also is required for chromosome congression and alignment during mitotic cell cycle process (PubMed:15843429). Regulates cell spreading, focal adhesion dynamics, and cell migration through its interaction with RADIL resulting in regulation of RAP1A-mediated inside-out integrin activation by tethering RADIL on microtubules (PubMed:23209302). {ECO:0000250|UniProtKB:L0N7N1, ECO:0000269|PubMed:15843429, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:16648480, ECO:0000269|PubMed:23209302, ECO:0000269|PubMed:24784001, ECO:0000269|PubMed:24854087}. |
| Q15149 | PLEC | S2755 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q15149 | PLEC | S3479 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q5THJ4 | VPS13D | S926 | ochoa | Intermembrane lipid transfer protein VPS13D (Vacuolar protein sorting-associated protein 13D) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:29307555, ECO:0000269|PubMed:29604224}. |
| Q6NUQ4 | TMEM214 | S456 | ochoa | Transmembrane protein 214 | Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress. {ECO:0000269|PubMed:23661706}. |
| Q6PJT7 | ZC3H14 | S553 | ochoa | Zinc finger CCCH domain-containing protein 14 (Mammalian suppressor of tau pathology-2) (MSUT-2) (Renal carcinoma antigen NY-REN-37) | RNA-binding protein involved in the biogenesis of circular RNAs (circRNAs), which are produced by back-splicing circularization of pre-mRNAs (PubMed:39461343). Acts by binding to both exon-intron boundary and 3'-UTR of pre-mRNAs to promote circRNA biogenesis through dimerization and the association with the spliceosome (PubMed:39461343). Required for spermatogenesis via involvement in circRNA biogenesis (PubMed:39461343). Regulates the pre-mRNA processing of ATP5MC1; preventing its degradation (PubMed:27563065). Also binds the poly(A) tail of mRNAs; controlling poly(A) length in neuronal cells (PubMed:17630287, PubMed:24671764). {ECO:0000269|PubMed:17630287, ECO:0000269|PubMed:24671764, ECO:0000269|PubMed:27563065, ECO:0000269|PubMed:39461343}. |
| Q6ZRV2 | FAM83H | S667 | ochoa | Protein FAM83H | May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:18252228, ECO:0000269|PubMed:23902688}. |
| Q6ZS17 | RIPOR1 | S114 | ochoa | Rho family-interacting cell polarization regulator 1 | Downstream effector protein for Rho-type small GTPases that plays a role in cell polarity and directional migration (PubMed:27807006). Acts as an adapter protein, linking active Rho proteins to STK24 and STK26 kinases, and hence positively regulates Golgi reorientation in polarized cell migration upon Rho activation (PubMed:27807006). Involved in the subcellular relocation of STK26 from the Golgi to cytoplasm punctae in a Rho- and PDCD10-dependent manner upon serum stimulation (PubMed:27807006). {ECO:0000269|PubMed:27807006}. |
| Q6ZU80 | CEP128 | S950 | ochoa | Centrosomal protein of 128 kDa (Cep128) | None |
| Q86VP1 | TAX1BP1 | S240 | ochoa | Tax1-binding protein 1 (TRAF6-binding protein) | Ubiquitin-binding adapter that participates in inflammatory, antiviral and innate immune processes as well as selective autophagy regulation (PubMed:29940186, PubMed:30459273, PubMed:30909570). Plays a key role in the negative regulation of NF-kappa-B and IRF3 signalings by acting as an adapter for the ubiquitin-editing enzyme A20/TNFAIP3 to bind and inactivate its substrates (PubMed:17703191). Disrupts the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKBKE to attenuate 'Lys63'-linked polyubiquitination of TBK1 and thereby IFN-beta production (PubMed:21885437). Also recruits A20/TNFAIP3 to ubiquitinated signaling proteins TRAF6 and RIPK1, leading to their deubiquitination and disruption of IL-1 and TNF-induced NF-kappa-B signaling pathways (PubMed:17703191). Inhibits virus-induced apoptosis by inducing the 'Lys-48'-linked polyubiquitination and degradation of MAVS via recruitment of the E3 ligase ITCH, thereby attenuating MAVS-mediated apoptosis signaling (PubMed:27736772). As a macroautophagy/autophagy receptor, facilitates the xenophagic clearance of pathogenic bacteria such as Salmonella typhimurium and Mycobacterium tuberculosis (PubMed:26451915). Upon NBR1 recruitment to the SQSTM1-ubiquitin condensates, acts as the major recruiter of RB1CC1 to these ubiquitin condensates to promote their autophagic degradation (PubMed:33226137, PubMed:34471133). Mediates the autophagic degradation of other substrates including TICAM1 (PubMed:28898289). {ECO:0000269|PubMed:10435631, ECO:0000269|PubMed:10920205, ECO:0000269|PubMed:17703191, ECO:0000269|PubMed:21885437, ECO:0000269|PubMed:26451915, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:28898289, ECO:0000269|PubMed:29940186, ECO:0000269|PubMed:30459273, ECO:0000269|PubMed:30909570, ECO:0000269|PubMed:33226137, ECO:0000269|PubMed:34471133}. |
| Q86X02 | CDR2L | S180 | ochoa | Cerebellar degeneration-related protein 2-like (Paraneoplastic 62 kDa antigen) | None |
| Q8IUG5 | MYO18B | S1545 | ochoa | Unconventional myosin-XVIIIb | May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth. |
| Q8IY81 | FTSJ3 | S676 | ochoa | pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 (EC 2.1.1.-) (Protein ftsJ homolog 3) (Putative rRNA methyltransferase 3) | RNA 2'-O-methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. {ECO:0000255|HAMAP-Rule:MF_03163, ECO:0000269|PubMed:22195017}.; FUNCTION: (Microbial infection) In case of infection by HIV-1 virus, recruited to HIV-1 RNA and catalyzes 2'-O-methylation of the viral genome, allowing HIV-1 virus to escape the innate immune system (PubMed:30626973). RNA 2'-O-methylation provides a molecular signature for discrimination of self from non-self and is used by HIV-1 to evade innate immune recognition by IFIH1/MDA5 (PubMed:30626973). Mediates methylation of internal residues of HIV-1 RNA, with a strong preference for adenosine (PubMed:30626973). Recruited to HIV-1 RNA via interaction with TARBP2/TRBP (PubMed:30626973). {ECO:0000269|PubMed:30626973}. |
| Q8NB49 | ATP11C | S234 | ochoa | Phospholipid-transporting ATPase IG (EC 7.6.2.1) (ATPase IQ) (ATPase class VI type 11C) (P4-ATPase flippase complex alpha subunit ATP11C) | Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of the plasma membrane (PubMed:24904167, PubMed:25315773, PubMed:26567335, PubMed:32493773). Major PS-flippase in immune cell subsets. In erythrocyte plasma membrane, it is required to maintain PS in the inner leaflet preventing its exposure on the surface. This asymmetric distribution is critical for the survival of erythrocytes in circulation since externalized PS is a phagocytic signal for erythrocyte clearance by splenic macrophages (PubMed:26944472). Required for B cell differentiation past the pro-B cell stage (By similarity). Seems to mediate PS flipping in pro-B cells (By similarity). May be involved in the transport of cholestatic bile acids (By similarity). {ECO:0000250|UniProtKB:Q9QZW0, ECO:0000269|PubMed:24904167, ECO:0000269|PubMed:25315773, ECO:0000269|PubMed:26944472, ECO:0000269|PubMed:32493773}. |
| Q8TBA6 | GOLGA5 | S583 | ochoa | Golgin subfamily A member 5 (Cell proliferation-inducing gene 31 protein) (Golgin-84) (Protein Ret-II) (RET-fused gene 5 protein) | Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport. {ECO:0000269|PubMed:12538640, ECO:0000269|PubMed:15718469}. |
| Q8WVM8 | SCFD1 | S252 | ochoa | Sec1 family domain-containing protein 1 (SLY1 homolog) (Sly1p) (Syntaxin-binding protein 1-like 2) | Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity). {ECO:0000250}. |
| Q8WVV4 | POF1B | S495 | ochoa | Protein POF1B (Premature ovarian failure protein 1B) | Plays a key role in the organization of epithelial monolayers by regulating the actin cytoskeleton. May be involved in ovary development. {ECO:0000269|PubMed:16773570, ECO:0000269|PubMed:21940798}. |
| Q8WXH0 | SYNE2 | S1111 | ochoa | Nesprin-2 (KASH domain-containing protein 2) (KASH2) (Nuclear envelope spectrin repeat protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE) (Synaptic nuclear envelope protein 2) (Syne-2) | Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (PubMed:34818527). Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. May be involved in nucleus-centrosome attachment. During interkinetic nuclear migration (INM) at G2 phase and nuclear migration in neural progenitors its LINC complex association with SUN1/2 and probable association with cytoplasmic dynein-dynactin motor complexes functions to pull the nucleus toward the centrosome; SYNE1 and SYNE2 may act redundantly. During INM at G1 phase mediates respective LINC complex association with kinesin to push the nucleus away from the centrosome. Involved in nuclear migration in retinal photoreceptor progenitors. Required for centrosome migration to the apical cell surface during early ciliogenesis. Facilitates the relaxation of mechanical stress imposed by compressive actin fibers at the rupture site through its nteraction with SYN2 (PubMed:34818527). {ECO:0000250|UniProtKB:Q6ZWQ0, ECO:0000269|PubMed:12118075, ECO:0000269|PubMed:18396275, ECO:0000269|PubMed:19596800, ECO:0000269|PubMed:20724637, ECO:0000269|PubMed:22945352, ECO:0000269|PubMed:34818527}. |
| Q8WXH0 | SYNE2 | S5860 | ochoa | Nesprin-2 (KASH domain-containing protein 2) (KASH2) (Nuclear envelope spectrin repeat protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE) (Synaptic nuclear envelope protein 2) (Syne-2) | Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (PubMed:34818527). Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. May be involved in nucleus-centrosome attachment. During interkinetic nuclear migration (INM) at G2 phase and nuclear migration in neural progenitors its LINC complex association with SUN1/2 and probable association with cytoplasmic dynein-dynactin motor complexes functions to pull the nucleus toward the centrosome; SYNE1 and SYNE2 may act redundantly. During INM at G1 phase mediates respective LINC complex association with kinesin to push the nucleus away from the centrosome. Involved in nuclear migration in retinal photoreceptor progenitors. Required for centrosome migration to the apical cell surface during early ciliogenesis. Facilitates the relaxation of mechanical stress imposed by compressive actin fibers at the rupture site through its nteraction with SYN2 (PubMed:34818527). {ECO:0000250|UniProtKB:Q6ZWQ0, ECO:0000269|PubMed:12118075, ECO:0000269|PubMed:18396275, ECO:0000269|PubMed:19596800, ECO:0000269|PubMed:20724637, ECO:0000269|PubMed:22945352, ECO:0000269|PubMed:34818527}. |
| Q92870 | APBB2 | S160 | ochoa | Amyloid beta precursor protein binding family B member 2 (Amyloid-beta (A4) precursor protein-binding family B member 2) (Protein Fe65-like 1) | Plays a role in the maintenance of lens transparency, and may also play a role in muscle cell strength (By similarity). Involved in hippocampal neurite branching and neuromuscular junction formation, as a result plays a role in spatial memory functioning (By similarity). Activates transcription of APP (PubMed:14527950). {ECO:0000250|UniProtKB:Q9DBR4, ECO:0000269|PubMed:14527950}. |
| Q969K3 | RNF34 | S284 | ochoa | E3 ubiquitin-protein ligase RNF34 (EC 2.3.2.27) (Caspase regulator CARP1) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (RING finger protein 34) (RING finger protein RIFF) (RING-type E3 ubiquitin transferase RNF34) | E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis (PubMed:15069192). May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway (Ref.13). Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation (PubMed:17121812). Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN (PubMed:18382127). Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells (PubMed:22064484). Possibly involved in innate immunity, through 'Lys-48'-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation (PubMed:25012219). {ECO:0000269|PubMed:12118383, ECO:0000269|PubMed:15069192, ECO:0000269|PubMed:15897238, ECO:0000269|PubMed:17121812, ECO:0000269|PubMed:22064484, ECO:0000269|PubMed:25012219, ECO:0000269|Ref.13, ECO:0000303|PubMed:18382127}. |
| Q96AJ9 | VTI1A | S110 | ochoa | Vesicle transport through interaction with t-SNAREs homolog 1A (Vesicle transport v-SNARE protein Vti1-like 2) (Vti1-rp2) | V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non-conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular senescence. {ECO:0000269|PubMed:18195106, ECO:0000269|PubMed:19138172}. |
| Q96C24 | SYTL4 | S180 | ochoa | Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin) | Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By similarity). {ECO:0000250}. |
| Q96MT8 | CEP63 | S468 | ochoa | Centrosomal protein of 63 kDa (Cep63) | Required for normal spindle assembly (PubMed:21406398, PubMed:21983783, PubMed:26297806, PubMed:35793002). Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:21983783, PubMed:26297806). Reported to be required for centrosomal recruitment of CEP152; however, this function has been questioned (PubMed:21983783, PubMed:26297806). Also recruits CDK1 to centrosomes (PubMed:21406398). Plays a role in DNA damage response (PubMed:21406398). Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (PubMed:21406398). Promotes stabilization of FXR1 protein by inhibiting FXR1 ubiquitination (PubMed:35989368). {ECO:0000269|PubMed:21406398, ECO:0000269|PubMed:21983783, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:35793002, ECO:0000269|PubMed:35989368}. |
| Q96N67 | DOCK7 | S964 | ochoa | Dedicator of cytokinesis protein 7 | Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity). {ECO:0000250|UniProtKB:Q8R1A4, ECO:0000269|PubMed:16982419, ECO:0000269|PubMed:29467281}. |
| Q99549 | MPHOSPH8 | S182 | ochoa | M-phase phosphoprotein 8 (Two hybrid-associated protein 3 with RanBPM) (Twa3) | Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416). Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene (PubMed:20871592). Mediates down-regulation of CDH1 expression (PubMed:20871592). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). {ECO:0000269|PubMed:20871592, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}. |
| Q9BSC4 | NOL10 | S603 | ochoa | Nucleolar protein 10 | None |
| Q9BV73 | CEP250 | S460 | ochoa | Centrosome-associated protein CEP250 (250 kDa centrosomal protein) (Cep250) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Centrosomal protein 2) | Plays an important role in centrosome cohesion during interphase (PubMed:30404835, PubMed:36282799). Recruits CCDC102B to the proximal ends of centrioles (PubMed:30404835). Maintains centrosome cohesion by forming intercentriolar linkages (PubMed:36282799). Accumulates at the proximal end of each centriole, forming supramolecular assemblies with viscous material properties that promote organelle cohesion (PubMed:36282799). May be involved in ciliogenesis (PubMed:28005958). {ECO:0000269|PubMed:28005958, ECO:0000269|PubMed:30404835, ECO:0000269|PubMed:36282799}. |
| Q9BV73 | CEP250 | S2267 | ochoa | Centrosome-associated protein CEP250 (250 kDa centrosomal protein) (Cep250) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Centrosomal protein 2) | Plays an important role in centrosome cohesion during interphase (PubMed:30404835, PubMed:36282799). Recruits CCDC102B to the proximal ends of centrioles (PubMed:30404835). Maintains centrosome cohesion by forming intercentriolar linkages (PubMed:36282799). Accumulates at the proximal end of each centriole, forming supramolecular assemblies with viscous material properties that promote organelle cohesion (PubMed:36282799). May be involved in ciliogenesis (PubMed:28005958). {ECO:0000269|PubMed:28005958, ECO:0000269|PubMed:30404835, ECO:0000269|PubMed:36282799}. |
| Q9BVA1 | TUBB2B | S115 | ochoa | Tubulin beta-2B chain | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:23001566, PubMed:26732629, PubMed:28013290). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910). {ECO:0000269|PubMed:19465910, ECO:0000269|PubMed:23001566, ECO:0000269|PubMed:26732629, ECO:0000269|PubMed:28013290}. |
| Q9BWH6 | RPAP1 | S301 | ochoa | RNA polymerase II-associated protein 1 | Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Required for interaction of the RNA polymerase II complex with acetylated histone H3. {ECO:0000269|PubMed:17643375}. |
| Q9BXM7 | PINK1 | S284 | psp | Serine/threonine-protein kinase PINK1, mitochondrial (EC 2.7.11.1) (BRPK) (PTEN-induced putative kinase protein 1) | Serine/threonine-protein kinase which acts as a sensor of mitochondrial damage and protects against mitochondrial dysfunction during cellular stress. It phosphorylates mitochondrial proteins to coordinate mitochondrial quality control mechanisms that remove and replace dysfunctional mitochondrial components (PubMed:14607334, PubMed:15087508, PubMed:18443288, PubMed:18957282, PubMed:19229105, PubMed:19966284, PubMed:20404107, PubMed:20547144, PubMed:20798600, PubMed:22396657, PubMed:23620051, PubMed:23754282, PubMed:23933751, PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:24896179, PubMed:24898855, PubMed:25527291, PubMed:32484300). Depending on the severity of mitochondrial damage, activity ranges from preventing apoptosis and stimulating mitochondrial biogenesis to eliminating severely damaged mitochondria via PINK1-PRKN-dependent mitophagy (PubMed:14607334, PubMed:15087508, PubMed:18443288, PubMed:19966284, PubMed:20404107, PubMed:20798600, PubMed:22396657, PubMed:23620051, PubMed:23933751, PubMed:24898855, PubMed:32047033, PubMed:32484300). When cellular stress results in irreversible mitochondrial damage, PINK1 accumulates at the outer mitochondrial membrane (OMM) where it phosphorylates pre-existing polyubiquitin chains at 'Ser-65', recruits PRKN from the cytosol to the OMM and activates PRKN by phosphorylation at 'Ser-65'; activated PRKN then ubiquinates VDAC1 and other OMM proteins to initiate mitophagy (PubMed:14607334, PubMed:15087508, PubMed:19966284, PubMed:20404107, PubMed:20798600, PubMed:23754282, PubMed:23933751, PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25474007, PubMed:25527291, PubMed:32047033). The PINK1-PRKN pathway also promotes fission of damaged mitochondria through phosphorylation and PRKN-dependent degradation of mitochondrial proteins involved in fission such as MFN2 (PubMed:18443288, PubMed:23620051, PubMed:24898855). This prevents the refusion of unhealthy mitochondria with the mitochondrial network or initiates mitochondrial fragmentation facilitating their later engulfment by autophagosomes (PubMed:18443288, PubMed:23620051). Also promotes mitochondrial fission independently of PRKN and ATG7-mediated mitophagy, via the phosphorylation and activation of DNM1L (PubMed:18443288, PubMed:32484300). Regulates motility of damaged mitochondria by promoting the ubiquitination and subsequent degradation of MIRO1 and MIRO2; in motor neurons, this likely inhibits mitochondrial intracellular anterograde transport along the axons which probably increases the chance of the mitochondria undergoing mitophagy in the soma (PubMed:22396657). Required for ubiquinone reduction by mitochondrial complex I by mediating phosphorylation of complex I subunit NDUFA10 (By similarity). Phosphorylates LETM1, positively regulating its mitochondrial calcium transport activity (PubMed:29123128). {ECO:0000250|UniProtKB:Q99MQ3, ECO:0000269|PubMed:14607334, ECO:0000269|PubMed:15087508, ECO:0000269|PubMed:18443288, ECO:0000269|PubMed:18957282, ECO:0000269|PubMed:19229105, ECO:0000269|PubMed:19966284, ECO:0000269|PubMed:20404107, ECO:0000269|PubMed:20547144, ECO:0000269|PubMed:20798600, ECO:0000269|PubMed:22396657, ECO:0000269|PubMed:23620051, ECO:0000269|PubMed:23754282, ECO:0000269|PubMed:23933751, ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:24896179, ECO:0000269|PubMed:24898855, ECO:0000269|PubMed:25474007, ECO:0000269|PubMed:25527291, ECO:0000269|PubMed:29123128, ECO:0000269|PubMed:32047033, ECO:0000269|PubMed:32484300}. |
| Q9GZM8 | NDEL1 | S155 | psp | Nuclear distribution protein nudE-like 1 (Protein Nudel) (Mitosin-associated protein 1) | Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). Plays a role, together with DISC1, in the regulation of neurite outgrowth (By similarity). May act as a RAB9A/B effector that tethers RAB9-associated late endosomes to the dynein motor for their retrograde transport to the trans-Golgi network (PubMed:34793709). {ECO:0000250|UniProtKB:Q78PB6, ECO:0000250|UniProtKB:Q9ERR1, ECO:0000269|PubMed:12556484, ECO:0000269|PubMed:14970193, ECO:0000269|PubMed:16291865, ECO:0000269|PubMed:17600710, ECO:0000269|PubMed:34793709}. |
| Q9H2D6 | TRIOBP | S1995 | ochoa | TRIO and F-actin-binding protein (Protein Tara) (TRF1-associated protein of 68 kDa) (Trio-associated repeat on actin) | [Isoform 1]: Regulates actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin and prevents its depolymerization (PubMed:18194665, PubMed:28438837). May also serve as a linker protein to recruit proteins required for F-actin formation and turnover (PubMed:18194665). Essential for correct mitotic progression (PubMed:22820163, PubMed:24692559). {ECO:0000269|PubMed:18194665, ECO:0000269|PubMed:22820163, ECO:0000269|PubMed:24692559, ECO:0000269|PubMed:28438837}.; FUNCTION: [Isoform 5]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}.; FUNCTION: [Isoform 4]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}. |
| Q9H2K0 | MTIF3 | S122 | ochoa | Translation initiation factor IF-3, mitochondrial (IF-3(Mt)) (IF-3Mt) (IF3(mt)) (IF3mt) | IF-3 binds to the 28S ribosomal subunit and shifts the equilibrium between 55S ribosomes and their 39S and 28S subunits in favor of the free subunits, thus enhancing the availability of 28S subunits on which protein synthesis initiation begins. {ECO:0000269|PubMed:12095986}. |
| Q9H2S1 | KCNN2 | S464 | psp | Small conductance calcium-activated potassium channel protein 2 (SK2) (SKCa 2) (SKCa2) (KCa2.2) | Small conductance calcium-activated potassium channel that mediates the voltage-independent transmembrane transfer of potassium across the cell membrane through a constitutive interaction with calmodulin which binds the intracellular calcium allowing its opening (PubMed:10991935, PubMed:33242881, PubMed:9287325). The current is characterized by a voltage-independent activation, an intracellular calcium concentration increase-dependent activation and a single-channel conductance of about 3 picosiemens (PubMed:10991935). Also presents an inwardly rectifying current, thus reducing its already small outward conductance of potassium ions, which is particularly the case when the membrane potential displays positive values, above + 20 mV (PubMed:10991935). The inward rectification could be due to a blockade of the outward current by intracellular divalent cations such as calcium and magnesium and could also be due to an intrinsic property of the channel pore, independent of intracellular divalent ions. There are three positively charged amino acids in the S6 transmembrane domain, close to the pore, that collectively control the conductance and rectification through an electrostatic mechanism. Additionally, electrostatic contributions from these residues also play an important role in determining the intrinsic open probability of the channel in the absence of calcium, affecting the apparent calcium affinity for activation. Forms an heteromeric complex with calmodulin, which is constitutively associated in a calcium-independent manner. Channel opening is triggered when calcium binds the calmodulin resulting in a rotary movement leading to the formation of the dimeric complex to open the gate (By similarity). Plays a role in the repolarization phase of cardiac action potential (PubMed:13679367). {ECO:0000250|UniProtKB:P70604, ECO:0000269|PubMed:10991935, ECO:0000269|PubMed:13679367, ECO:0000269|PubMed:33242881, ECO:0000269|PubMed:9287325}. |
| Q9H4G0 | EPB41L1 | S510 | ochoa | Band 4.1-like protein 1 (Erythrocyte membrane protein band 4.1-like 1) (Neuronal protein 4.1) (4.1N) | May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases. |
| Q9HD26 | GOPC | S86 | ochoa | Golgi-associated PDZ and coiled-coil motif-containing protein (CFTR-associated ligand) (Fused in glioblastoma) (PDZ protein interacting specifically with TC10) (PIST) | Plays a role in intracellular protein trafficking and degradation (PubMed:11707463, PubMed:14570915, PubMed:15358775). May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels (By similarity). May also regulate the intracellular trafficking of the ADR1B receptor (PubMed:15358775). May play a role in autophagy (By similarity). Together with MARCHF2 mediates the ubiquitination and lysosomal degradation of CFTR (PubMed:23818989). Overexpression results in CFTR intracellular retention and lysosomaldegradation in the lysosomes (PubMed:11707463, PubMed:14570915). {ECO:0000250|UniProtKB:Q8BH60, ECO:0000269|PubMed:11707463, ECO:0000269|PubMed:14570915, ECO:0000269|PubMed:15358775, ECO:0000269|PubMed:23818989}. |
| Q9HD67 | MYO10 | S915 | ochoa | Unconventional myosin-X (Unconventional myosin-10) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as a plus end-directed motor. Moves with higher velocity and takes larger steps on actin bundles than on single actin filaments (PubMed:27580874). The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation. Plays a role in formation of the podosome belt in osteoclasts. {ECO:0000269|PubMed:16894163, ECO:0000269|PubMed:18570893, ECO:0000269|PubMed:27580874}.; FUNCTION: [Isoform Headless]: Functions as a dominant-negative regulator of isoform 1, suppressing its filopodia-inducing and axon outgrowth-promoting activities. In hippocampal neurons, it increases VASP retention in spine heads to induce spine formation and spine head expansion (By similarity). {ECO:0000250|UniProtKB:F8VQB6}. |
| Q9P0J7 | KCMF1 | S219 | ochoa | E3 ubiquitin-protein ligase KCMF1 (EC 2.3.2.27) (FGF-induced in gastric cancer) (Potassium channel modulatory factor) (PCMF) (ZZ-type zinc finger-containing protein 1) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and then transfers it to targeted substrates, promoting their degradation by the proteasome (PubMed:15581609, PubMed:25582440, PubMed:34893540, PubMed:37891180, PubMed:38297121). Together with UBR4, component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR4, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). {ECO:0000269|PubMed:15581609, ECO:0000269|PubMed:25582440, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:37891180, ECO:0000269|PubMed:38297121}. |
| Q9P225 | DNAH2 | S334 | ochoa | Dynein axonemal heavy chain 2 (Axonemal beta dynein heavy chain 2) (Ciliary dynein heavy chain 2) (Dynein heavy chain domain-containing protein 3) | As part of the axonemal inner dynein arm complex plays a central role in ciliary beat (PubMed:30811583). Expressed in sperm flagellum, it is required for sperm motility (PubMed:30811583). Dyneins are microtubule-based molecular motors possessing ATPase activities that can convert the chemical energy of ATP into relative sliding between adjacent microtubule doublets to generate ciliary bending (PubMed:30811583). {ECO:0000269|PubMed:30811583}. |
| Q9UDT6 | CLIP2 | S156 | ochoa | CAP-Gly domain-containing linker protein 2 (Cytoplasmic linker protein 115) (CLIP-115) (Cytoplasmic linker protein 2) (Williams-Beuren syndrome chromosomal region 3 protein) (Williams-Beuren syndrome chromosomal region 4 protein) | Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations (By similarity). {ECO:0000250}. |
| Q9UIF8 | BAZ2B | S335 | ochoa | Bromodomain adjacent to zinc finger domain protein 2B (hWALp4) | Regulatory subunit of the ATP-dependent BRF-1 and BRF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The BRF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the BRF-5 ISWI chromatin remodeling complex (PubMed:28801535). Chromatin reader protein, which may play a role in transcriptional regulation via interaction with ISWI (By similarity) (PubMed:10662543). Involved in positively modulating the rate of age-related behavioral deterioration (By similarity). Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with histone methyltransferase EHMT1 (By similarity). {ECO:0000250|UniProtKB:A2AUY4, ECO:0000269|PubMed:28801535, ECO:0000303|PubMed:10662543}. |
| Q9UKX2 | MYH2 | T1025 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9ULF5 | SLC39A10 | S570 | ochoa | Zinc transporter ZIP10 (Solute carrier family 39 member 10) (Zrt- and Irt-like protein 10) (ZIP-10) | Zinc-influx transporter (PubMed:17359283, PubMed:27274087, PubMed:30520657). When associated with SLC39A6, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial-to-mesenchymal transition (EMT) (PubMed:23186163). SLC39A10-SLC39A6 heterodimers play also an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis (PubMed:32797246). Plays an important for both mature B-cell maintenance and humoral immune responses (By similarity). When associated with SLC39A10, the heterodimer controls NCAM1 phosphorylation and integration into focal adhesion complexes during EMT (By similarity). {ECO:0000250|UniProtKB:Q6P5F6, ECO:0000269|PubMed:17359283, ECO:0000269|PubMed:23186163, ECO:0000269|PubMed:27274087, ECO:0000269|PubMed:30520657, ECO:0000269|PubMed:32797246}. |
| Q9UPU7 | TBC1D2B | S360 | ochoa | TBC1 domain family member 2B | GTPase-activating protein that plays a role in the early steps of endocytosis (PubMed:32623794). {ECO:0000269|PubMed:32623794}. |
| Q9Y2X7 | GIT1 | S449 | psp | ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) (p95-APP1) | GTPase-activating protein for ADP ribosylation factor family members, including ARF1. Multidomain scaffold protein that interacts with numerous proteins and therefore participates in many cellular functions, including receptor internalization, focal adhesion remodeling, and signaling by both G protein-coupled receptors and tyrosine kinase receptors (By similarity). Through PAK1 activation, positively regulates microtubule nucleation during interphase (PubMed:27012601). Plays a role in the regulation of cytokinesis; for this function, may act in a pathway also involving ENTR1 and PTPN13 (PubMed:23108400). May promote cell motility both by regulating focal complex dynamics and by local activation of RAC1 (PubMed:10938112, PubMed:11896197). May act as scaffold for MAPK1/3 signal transduction in focal adhesions. Recruits MAPK1/3/ERK1/2 to focal adhesions after EGF stimulation via a Src-dependent pathway, hence stimulating cell migration (PubMed:15923189). Plays a role in brain development and function. Involved in the regulation of spine density and synaptic plasticity that is required for processes involved in learning (By similarity). Plays an important role in dendritic spine morphogenesis and synapse formation (PubMed:12695502, PubMed:15800193). In hippocampal neurons, recruits guanine nucleotide exchange factors (GEFs), such as ARHGEF7/beta-PIX, to the synaptic membrane. These in turn locally activate RAC1, which is an essential step for spine morphogenesis and synapse formation (PubMed:12695502). May contribute to the organization of presynaptic active zones through oligomerization and formation of a Piccolo/PCLO-based protein network, which includes ARHGEF7/beta-PIX and FAK1 (By similarity). In neurons, through its interaction with liprin-alpha family members, may be required for AMPA receptor (GRIA2/3) proper targeting to the cell membrane (By similarity). In complex with GABA(A) receptors and ARHGEF7, plays a crucial role in regulating GABA(A) receptor synaptic stability, maintaining GPHN/gephyrin scaffolds and hence GABAergic inhibitory synaptic transmission, by locally coordinating RAC1 and PAK1 downstream effector activity, leading to F-actin stabilization (PubMed:25284783). May also be important for RAC1 downstream signaling pathway through PAK3 and regulation of neuronal inhibitory transmission at presynaptic input (By similarity). Required for successful bone regeneration during fracture healing (By similarity). The function in intramembranous ossification may, at least partly, exerted by macrophages in which GIT1 is a key negative regulator of redox homeostasis, IL1B production, and glycolysis, acting through the ERK1/2/NRF2/NFE2L2 axis (By similarity). May play a role in angiogenesis during fracture healing (By similarity). In this process, may regulate activation of the canonical NF-kappa-B signal in bone mesenchymal stem cells by enhancing the interaction between NEMO and 'Lys-63'-ubiquitinated RIPK1/RIP1, eventually leading to enhanced production of VEGFA and others angiogenic factors (PubMed:31502302). Essential for VEGF signaling through the activation of phospholipase C-gamma and ERK1/2, hence may control endothelial cell proliferation and angiogenesis (PubMed:19273721). {ECO:0000250|UniProtKB:Q68FF6, ECO:0000250|UniProtKB:Q9Z272, ECO:0000269|PubMed:10938112, ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:12695502, ECO:0000269|PubMed:15800193, ECO:0000269|PubMed:15923189, ECO:0000269|PubMed:19273721, ECO:0000269|PubMed:23108400, ECO:0000269|PubMed:25284783, ECO:0000269|PubMed:27012601, ECO:0000269|PubMed:31502302}. |
| O95678 | KRT75 | S162 | Sugiyama | Keratin, type II cytoskeletal 75 (Cytokeratin-75) (CK-75) (Keratin-6 hair follicle) (hK6hf) (Keratin-75) (K75) (Type II keratin-K6hf) (Type-II keratin Kb18) | Plays a central role in hair and nail formation. Essential component of keratin intermediate filaments in the companion layer of the hair follicle. |
| P02538 | KRT6A | S176 | Sugiyama | Keratin, type II cytoskeletal 6A (Cytokeratin-6A) (CK-6A) (Cytokeratin-6D) (CK-6D) (Keratin-6A) (K6A) (Type-II keratin Kb6) (allergen Hom s 5) | Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair. {ECO:0000250|UniProtKB:P50446}. |
| P04259 | KRT6B | S176 | Sugiyama | Keratin, type II cytoskeletal 6B (Cytokeratin-6B) (CK-6B) (Keratin-6B) (K6B) (Type-II keratin Kb10) | None |
| P05787 | KRT8 | S104 | Sugiyama | Keratin, type II cytoskeletal 8 (Cytokeratin-8) (CK-8) (Keratin-8) (K8) (Type-II keratin Kb8) | Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. {ECO:0000269|PubMed:16000376}. |
| P08729 | KRT7 | S104 | Sugiyama | Keratin, type II cytoskeletal 7 (Cytokeratin-7) (CK-7) (Keratin-7) (K7) (Sarcolectin) (Type-II keratin Kb7) | Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7). {ECO:0000269|PubMed:10492017, ECO:0000269|PubMed:12072504}. |
| P12035 | KRT3 | S211 | Sugiyama | Keratin, type II cytoskeletal 3 (65 kDa cytokeratin) (Cytokeratin-3) (CK-3) (Keratin-3) (K3) (Type-II keratin Kb3) | None |
| P13647 | KRT5 | S181 | Sugiyama | Keratin, type II cytoskeletal 5 (58 kDa cytokeratin) (Cytokeratin-5) (CK-5) (Keratin-5) (K5) (Type-II keratin Kb5) | Required for the formation of keratin intermediate filaments in the basal epidermis and maintenance of the skin barrier in response to mechanical stress (By similarity). Regulates the recruitment of Langerhans cells to the epidermis, potentially by modulation of the abundance of macrophage chemotactic cytokines, macrophage inflammatory cytokines and CTNND1 localization in keratinocytes (By similarity). {ECO:0000250|UniProtKB:Q922U2}. |
| P35908 | KRT2 | S191 | Sugiyama | Keratin, type II cytoskeletal 2 epidermal (Cytokeratin-2e) (CK-2e) (Epithelial keratin-2e) (Keratin-2 epidermis) (Keratin-2e) (K2e) (Type-II keratin Kb2) | Probably contributes to terminal cornification (PubMed:1380918). Associated with keratinocyte activation, proliferation and keratinization (PubMed:12598329). Required for maintenance of corneocytes and keratin filaments in suprabasal keratinocytes in the epidermis of the ear, potentially via moderation of expression and localization of keratins and their partner proteins (By similarity). Plays a role in the establishment of the epidermal barrier on plantar skin (By similarity). {ECO:0000250|UniProtKB:Q3TTY5, ECO:0000269|PubMed:12598329, ECO:0000269|PubMed:1380918}. |
| P48668 | KRT6C | S176 | Sugiyama | Keratin, type II cytoskeletal 6C (Cytokeratin-6C) (CK-6C) (Cytokeratin-6E) (CK-6E) (Keratin K6h) (Keratin-6C) (K6C) (Type-II keratin Kb12) | None |
| Q01546 | KRT76 | S196 | Sugiyama | Keratin, type II cytoskeletal 2 oral (Cytokeratin-2P) (CK-2P) (K2P) (Keratin-76) (K76) (Type-II keratin Kb9) | Probably contributes to terminal cornification. {ECO:0000269|PubMed:1282112}. |
| Q14CN4 | KRT72 | S138 | Sugiyama | Keratin, type II cytoskeletal 72 (Cytokeratin-72) (CK-72) (Keratin-72) (K72) (Type II inner root sheath-specific keratin-K6irs2) (Type-II keratin Kb35) | Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable). {ECO:0000305}. |
| Q3SY84 | KRT71 | S143 | Sugiyama | Keratin, type II cytoskeletal 71 (Cytokeratin-71) (CK-71) (Keratin-71) (K71) (Type II inner root sheath-specific keratin-K6irs1) (Keratin 6 irs) (hK6irs) (hK6irs1) (Type-II keratin Kb34) | Plays a central role in hair formation. Essential component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle. {ECO:0000269|PubMed:22592156}. |
| Q5XKE5 | KRT79 | S155 | Sugiyama | Keratin, type II cytoskeletal 79 (Cytokeratin-79) (CK-79) (Keratin-6-like) (Keratin-6L) (Keratin-79) (K79) (Type-II keratin Kb38) | None |
| Q7RTS7 | KRT74 | S153 | Sugiyama | Keratin, type II cytoskeletal 74 (Cytokeratin-74) (CK-74) (Keratin-5c) (K5C) (Keratin-74) (K74) (Type II inner root sheath-specific keratin-K6irs4) (Type-II keratin Kb37) | Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable). {ECO:0000305}. |
| Q7Z794 | KRT77 | S177 | Sugiyama | Keratin, type II cytoskeletal 1b (Cytokeratin-1B) (CK-1B) (Keratin-77) (K77) (Type-II keratin Kb39) | None |
| Q86Y46 | KRT73 | S145 | Sugiyama | Keratin, type II cytoskeletal 73 (Cytokeratin-73) (CK-73) (Keratin-73) (K73) (Type II inner root sheath-specific keratin-K6irs3) (Type-II keratin Kb36) | Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable). {ECO:0000305}. |
| Q9NSB2 | KRT84 | S178 | Sugiyama | Keratin, type II cuticular Hb4 (Keratin-84) (K84) (Type II hair keratin Hb4) (Type-II keratin Kb24) | None |
| O00231 | PSMD11 | S298 | Sugiyama | 26S proteasome non-ATPase regulatory subunit 11 (26S proteasome regulatory subunit RPN6) (26S proteasome regulatory subunit S9) (26S proteasome regulatory subunit p44.5) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity. {ECO:0000269|PubMed:1317798, ECO:0000269|PubMed:22972301}. |
| P05783 | KRT18 | S93 | Sugiyama | Keratin, type I cytoskeletal 18 (Cell proliferation-inducing gene 46 protein) (Cytokeratin-18) (CK-18) (Keratin-18) (K18) | Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. {ECO:0000250, ECO:0000269|PubMed:15529338, ECO:0000269|PubMed:16424149, ECO:0000269|PubMed:17213200, ECO:0000269|PubMed:7523419, ECO:0000269|PubMed:8522591, ECO:0000269|PubMed:9298992, ECO:0000269|PubMed:9524113}. |
| O43324 | EEF1E1 | S100 | Sugiyama | Eukaryotic translation elongation factor 1 epsilon-1 (Aminoacyl tRNA synthetase complex-interacting multifunctional protein 3) (Elongation factor p18) (Multisynthase complex auxiliary component p18) | Positive modulator of ATM response to DNA damage. {ECO:0000250|UniProtKB:Q9D1M4}. |
| P29692 | EEF1D | S93 | Sugiyama | Elongation factor 1-delta (EF-1-delta) (Antigen NY-CO-4) | [Isoform 1]: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1-alpha for another round of transfer of aminoacyl-tRNAs to the ribosome.; FUNCTION: [Isoform 2]: Regulates induction of heat-shock-responsive genes through association with heat shock transcription factors and direct DNA-binding at heat shock promoter elements (HSE). |
| P33176 | KIF5B | S718 | Sugiyama | Kinesin-1 heavy chain (Conventional kinesin heavy chain) (Ubiquitous kinesin heavy chain) (UKHC) | Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends (Probable). Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). {ECO:0000250|UniProtKB:Q2PQA9, ECO:0000250|UniProtKB:Q61768, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:24088571, ECO:0000305|PubMed:22172677, ECO:0000305|PubMed:24088571}. |
| Q08378 | GOLGA3 | S924 | Sugiyama | Golgin subfamily A member 3 (Golgi complex-associated protein of 170 kDa) (GCP170) (Golgin-160) | Golgi auto-antigen; probably involved in maintaining Golgi structure. |
| Q86VS8 | HOOK3 | T291 | Sugiyama | Protein Hook homolog 3 (h-hook3) (hHK3) | Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Predominantly recruits 2 dyneins, which increases both the force and speed of the microtubule motor (PubMed:25035494, PubMed:33734450). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). {ECO:0000250|UniProtKB:Q8BUK6, ECO:0000269|PubMed:11238449, ECO:0000269|PubMed:17237231, ECO:0000269|PubMed:18799622, ECO:0000269|PubMed:25035494, ECO:0000269|PubMed:32073997, ECO:0000269|PubMed:33734450}.; FUNCTION: (Microbial infection) May serve as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking. {ECO:0000305}. |
| Q9UNE7 | STUB1 | S216 | Sugiyama | E3 ubiquitin-protein ligase CHIP (EC 2.3.2.27) (Antigen NY-CO-7) (CLL-associated antigen KW-8) (Carboxy terminus of Hsp70-interacting protein) (RING-type E3 ubiquitin transferase CHIP) (STIP1 homology and U box-containing protein 1) | E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation (PubMed:10330192, PubMed:11146632, PubMed:11557750, PubMed:23990462, PubMed:26265139). Plays a role in the maintenance of mitochondrial morphology and promotes mitophagic removal of dysfunctional mitochondria; thereby acts as a protector against apoptosis in response to cellular stress (By similarity). Negatively regulates vascular smooth muscle contraction, via degradation of the transcriptional activator MYOCD and subsequent loss of transcription of genes involved in vascular smooth muscle contraction (By similarity). Promotes survival and proliferation of cardiac smooth muscle cells via ubiquitination and degradation of FOXO1, resulting in subsequent repression of FOXO1-mediated transcription of pro-apoptotic genes (PubMed:19483080). Ubiquitinates ICER-type isoforms of CREM and targets them for proteasomal degradation, thereby acts as a positive effector of MAPK/ERK-mediated inhibition of apoptosis in cardiomyocytes (PubMed:20724525). Inhibits lipopolysaccharide-induced apoptosis and hypertrophy in cardiomyocytes, via ubiquitination and subsequent proteasomal degradation of NFATC3 (PubMed:30980393). Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (PubMed:10330192, PubMed:11146632, PubMed:11557750, PubMed:23990462). Ubiquitinates NOS1 in concert with Hsp70 and Hsp40 (PubMed:15466472). Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90 (PubMed:10330192, PubMed:11146632, PubMed:15466472). Ubiquitinates CHRNA3 targeting it for endoplasmic reticulum-associated degradation in cortical neurons, as part of the STUB1-VCP-UBXN2A complex (PubMed:26265139). Ubiquitinates and promotes ESR1 proteasomal degradation in response to age-related circulating estradiol (17-beta-estradiol/E2) decline, thereby promotes neuronal apoptosis in response to ischemic reperfusion injury (By similarity). Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation (PubMed:11557750, PubMed:23990462). Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome (PubMed:19713937). Mediates polyubiquitination of CYP3A4 (PubMed:19103148). Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation (PubMed:19567782). Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and promotes ubiquitin-mediated protein degradation (PubMed:27708256). Negatively regulates the suppressive function of regulatory T-cells (Treg) during inflammation by mediating the ubiquitination and degradation of FOXP3 in a HSPA1A/B-dependent manner (PubMed:23973223). Catalyzes monoubiquitination of SIRT6, preventing its degradation by the proteasome (PubMed:24043303). Likely mediates polyubiquitination and down-regulates plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity (PubMed:28813410). Negatively regulates TGF-beta signaling by modulating the basal level of SMAD3 via ubiquitin-mediated degradation (PubMed:24613385). Plays a role in the degradation of TP53 (PubMed:26634371). Mediates ubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation (PubMed:29883609). May regulate myosin assembly in striated muscles together with UBE4B and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (PubMed:17369820). Ubiquitinates PPARG in macrophages playing a role in M2 macrophages polarization and angiogenesis (By similarity). {ECO:0000250|UniProtKB:A6HD62, ECO:0000250|UniProtKB:Q9WUD1, ECO:0000269|PubMed:10330192, ECO:0000269|PubMed:11146632, ECO:0000269|PubMed:11557750, ECO:0000269|PubMed:15466472, ECO:0000269|PubMed:17369820, ECO:0000269|PubMed:19103148, ECO:0000269|PubMed:19483080, ECO:0000269|PubMed:19567782, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20724525, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24043303, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:26265139, ECO:0000269|PubMed:26634371, ECO:0000269|PubMed:27708256, ECO:0000269|PubMed:28813410, ECO:0000269|PubMed:29883609, ECO:0000269|PubMed:30980393}. |
| Q13620 | CUL4B | Y413 | Sugiyama | Cullin-4B (CUL-4B) | Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14578910, PubMed:16322693, PubMed:16678110, PubMed:18593899, PubMed:22118460, PubMed:29779948, PubMed:30166453, PubMed:33854232, PubMed:33854239). The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit (PubMed:14578910, PubMed:16678110, PubMed:18593899, PubMed:22118460, PubMed:29779948). CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme (PubMed:14578910, PubMed:16678110, PubMed:18593899, PubMed:22118460). Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage (PubMed:14578910, PubMed:16678110, PubMed:18593899). Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication (PubMed:16678110). A number of DCX complexes (containing either TRPC4AP or DCAF12 as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:29779948). The DCX(AMBRA1) complex is a master regulator of the transition from G1 to S cell phase by mediating ubiquitination of phosphorylated cyclin-D (CCND1, CCND2 and CCND3) (PubMed:33854232, PubMed:33854239). The DCX(AMBRA1) complex also acts as a regulator of Cul5-RING (CRL5) E3 ubiquitin-protein ligase complexes by mediating ubiquitination and degradation of Elongin-C (ELOC) component of CRL5 complexes (PubMed:30166453). Required for ubiquitination of cyclin E (CCNE1 or CCNE2), and consequently, normal G1 cell cycle progression (PubMed:16322693, PubMed:19801544). Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism (PubMed:18235224). Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8 (PubMed:18235224). With CUL4A, contributes to ribosome biogenesis (PubMed:26711351). {ECO:0000269|PubMed:14578910, ECO:0000269|PubMed:16322693, ECO:0000269|PubMed:16678110, ECO:0000269|PubMed:18235224, ECO:0000269|PubMed:18593899, ECO:0000269|PubMed:19801544, ECO:0000269|PubMed:22118460, ECO:0000269|PubMed:26711351, ECO:0000269|PubMed:29779948, ECO:0000269|PubMed:30166453, ECO:0000269|PubMed:33854232, ECO:0000269|PubMed:33854239}. |
| O75116 | ROCK2 | S535 | Sugiyama | Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho kinase 2) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2) | Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation. {ECO:0000269|PubMed:10579722, ECO:0000269|PubMed:15699075, ECO:0000269|PubMed:16574662, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21147781}. |
| O94804 | STK10 | S875 | Sugiyama | Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase) | Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. {ECO:0000269|PubMed:11903060, ECO:0000269|PubMed:12639966, ECO:0000269|PubMed:19255442}. |
| P02786 | TFRC | S159 | Sugiyama | Transferrin receptor protein 1 (TR) (TfR) (TfR1) (Trfr) (T9) (p90) (CD antigen CD71) [Cleaved into: Transferrin receptor protein 1, serum form (sTfR)] | Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes (PubMed:26214738). Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the hereditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240). Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway (PubMed:26214738). When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion (PubMed:26214738). When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2 (PubMed:26214738). Mediates uptake of NICOL1 into fibroblasts where it may regulate extracellular matrix production (By similarity). {ECO:0000250|UniProtKB:Q62351, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:26642240, ECO:0000269|PubMed:3568132}.; FUNCTION: (Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus. {ECO:0000269|PubMed:17287727, ECO:0000269|PubMed:18268337}.; FUNCTION: (Microbial infection) Acts as a host entry factor for rabies virus that hijacks the endocytosis of TFRC to enter cells. {ECO:0000269|PubMed:36779762, ECO:0000269|PubMed:36779763}.; FUNCTION: (Microbial infection) Acts as a host entry factor for SARS-CoV, MERS-CoV and SARS-CoV-2 viruses that hijack the endocytosis of TFRC to enter cells. {ECO:0000269|PubMed:36779762}. |
| Q9Y6K9 | IKBKG | S141 | GPS6 | NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier) | Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor (PubMed:14695475, PubMed:20724660, PubMed:21518757, PubMed:9751060). Its binding to scaffolding polyubiquitin plays a key role in IKK activation by multiple signaling receptor pathways (PubMed:16547522, PubMed:18287044, PubMed:19033441, PubMed:19185524, PubMed:21606507, PubMed:27777308, PubMed:33567255). Can recognize and bind both 'Lys-63'-linked and linear polyubiquitin upon cell stimulation, with a much higher affinity for linear polyubiquitin (PubMed:16547522, PubMed:18287044, PubMed:19033441, PubMed:19185524, PubMed:21606507, PubMed:27777308). Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3 (PubMed:19854139). Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination (PubMed:20724660). {ECO:0000269|PubMed:14695475, ECO:0000269|PubMed:16547522, ECO:0000269|PubMed:18287044, ECO:0000269|PubMed:19033441, ECO:0000269|PubMed:19185524, ECO:0000269|PubMed:19854139, ECO:0000269|PubMed:20724660, ECO:0000269|PubMed:21518757, ECO:0000269|PubMed:21606507, ECO:0000269|PubMed:27777308, ECO:0000269|PubMed:33567255, ECO:0000269|PubMed:9751060}.; FUNCTION: (Microbial infection) Also considered to be a mediator for HTLV-1 Tax oncoprotein activation of NF-kappa-B. {ECO:0000269|PubMed:10364167, ECO:0000269|PubMed:11064457}. |
| O43488 | AKR7A2 | S56 | Sugiyama | Aflatoxin B1 aldehyde reductase member 2 (EC 1.1.1.n11) (AFB1 aldehyde reductase 1) (AFB1-AR 1) (Aldoketoreductase 7) (Succinic semialdehyde reductase) (SSA reductase) | Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. {ECO:0000269|PubMed:17591773, ECO:0000269|PubMed:9576847}. |
| Q9Y5S2 | CDC42BPB | S470 | Sugiyama | Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (CDC42BP-beta) (DMPK-like beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (MRCK beta) (Myotonic dystrophy protein kinase-like beta) | Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715, PubMed:21949762). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates PPP1R12A (PubMed:21457715). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). {ECO:0000250|UniProtKB:Q7TT50, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:21949762}. |
| O00327 | BMAL1 | S90 | GPS6 | Basic helix-loop-helix ARNT-like protein 1 (Aryl hydrocarbon receptor nuclear translocator-like protein 1) (Basic-helix-loop-helix-PAS protein MOP3) (Brain and muscle ARNT-like 1) (Class E basic helix-loop-helix protein 5) (bHLHe5) (Member of PAS protein 3) (PAS domain-containing protein 3) (bHLH-PAS protein JAP3) | Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. BMAL1 positively regulates myogenesis and negatively regulates adipogenesis via the transcriptional control of the genes of the canonical Wnt signaling pathway. Plays a role in normal pancreatic beta-cell function; regulates glucose-stimulated insulin secretion via the regulation of antioxidant genes NFE2L2/NRF2 and its targets SESN2, PRDX3, CCLC and CCLM. Negatively regulates the mTORC1 signaling pathway; regulates the expression of MTOR and DEPTOR. Controls diurnal oscillations of Ly6C inflammatory monocytes; rhythmic recruitment of the PRC2 complex imparts diurnal variation to chemokine expression that is necessary to sustain Ly6C monocyte rhythms. Regulates the expression of HSD3B2, STAR, PTGS2, CYP11A1, CYP19A1 and LHCGR in the ovary and also the genes involved in hair growth. Plays an important role in adult hippocampal neurogenesis by regulating the timely entry of neural stem/progenitor cells (NSPCs) into the cell cycle and the number of cell divisions that take place prior to cell-cycle exit. Regulates the circadian expression of CIART and KLF11. The CLOCK-BMAL1 heterodimer regulates the circadian expression of SERPINE1/PAI1, VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1, GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1, ATF4, MTA1, KLF10 and also genes implicated in glucose and lipid metabolism. Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors. The NPAS2-BMAL1 heterodimer positively regulates the expression of MAOA, F7 and LDHA and modulates the circadian rhythm of daytime contrast sensitivity by regulating the rhythmic expression of adenylate cyclase type 1 (ADCY1) in the retina. The preferred binding motif for the CLOCK-BMAL1 heterodimer is 5'-CACGTGA-3', which contains a flanking adenine nucleotide at the 3-prime end of the canonical 6-nucleotide E-box sequence (PubMed:23229515). CLOCK specifically binds to the half-site 5'-CAC-3', while BMAL1 binds to the half-site 5'-GTGA-3' (PubMed:23229515). The CLOCK-BMAL1 heterodimer also recognizes the non-canonical E-box motifs 5'-AACGTGA-3' and 5'-CATGTGA-3' (PubMed:23229515). Essential for the rhythmic interaction of CLOCK with ASS1 and plays a critical role in positively regulating CLOCK-mediated acetylation of ASS1 (PubMed:28985504). Plays a role in protecting against lethal sepsis by limiting the expression of immune checkpoint protein CD274 in macrophages in a PKM2-dependent manner (By similarity). Regulates the diurnal rhythms of skeletal muscle metabolism via transcriptional activation of genes promoting triglyceride synthesis (DGAT2) and metabolic efficiency (COQ10B) (By similarity). {ECO:0000250|UniProtKB:Q9WTL8, ECO:0000269|PubMed:11441146, ECO:0000269|PubMed:12738229, ECO:0000269|PubMed:18587630, ECO:0000269|PubMed:23785138, ECO:0000269|PubMed:23955654, ECO:0000269|PubMed:24005054, ECO:0000269|PubMed:28985504}.; FUNCTION: (Microbial infection) Regulates SARS coronavirus-2/SARS-CoV-2 entry and replication in lung epithelial cells probably through the post-transcriptional regulation of ACE2 and interferon-stimulated gene expression. {ECO:0000269|PubMed:34545347}. |
| O00429 | DNM1L | S261 | Sugiyama | Dynamin-1-like protein (EC 3.6.5.5) (Dnm1p/Vps1p-like protein) (DVLP) (Dynamin family member proline-rich carboxyl-terminal domain less) (Dymple) (Dynamin-like protein) (Dynamin-like protein 4) (Dynamin-like protein IV) (HdynIV) (Dynamin-related protein 1) | Functions in mitochondrial and peroxisomal division (PubMed:11514614, PubMed:12499366, PubMed:17301055, PubMed:17460227, PubMed:17553808, PubMed:18695047, PubMed:18838687, PubMed:19342591, PubMed:19411255, PubMed:19638400, PubMed:23283981, PubMed:23530241, PubMed:23921378, PubMed:26992161, PubMed:27145208, PubMed:27145933, PubMed:27301544, PubMed:27328748, PubMed:29478834, PubMed:32439975, PubMed:32484300, PubMed:9570752, PubMed:9786947). Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism (PubMed:23530241, PubMed:23584531, PubMed:33850055). The specific recruitment at scission sites is mediated by membrane receptors like MFF, MIEF1 and MIEF2 for mitochondrial membranes (PubMed:23283981, PubMed:23921378, PubMed:29899447). While the recruitment by the membrane receptors is GTP-dependent, the following hydrolysis of GTP induces the dissociation from the receptors and allows DNM1L filaments to curl into closed rings that are probably sufficient to sever a double membrane (PubMed:29899447). Acts downstream of PINK1 to promote mitochondrial fission in a PRKN-dependent manner (PubMed:32484300). Plays an important role in mitochondrial fission during mitosis (PubMed:19411255, PubMed:26992161, PubMed:27301544, PubMed:27328748). Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage (By similarity). Required for normal brain development, including that of cerebellum (PubMed:17460227, PubMed:26992161, PubMed:27145208, PubMed:27301544, PubMed:27328748). Facilitates developmentally regulated apoptosis during neural tube formation (By similarity). Required for a normal rate of cytochrome c release and caspase activation during apoptosis; this requirement may depend upon the cell type and the physiological apoptotic cues (By similarity). Required for formation of endocytic vesicles (PubMed:20688057, PubMed:23792689, PubMed:9570752). Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles; the function may require its recruitment by MFF to clathrin-containing vesicles (PubMed:17015472, PubMed:23792689). Required for programmed necrosis execution (PubMed:22265414). Rhythmic control of its activity following phosphorylation at Ser-637 is essential for the circadian control of mitochondrial ATP production (PubMed:29478834). {ECO:0000250|UniProtKB:Q8K1M6, ECO:0000269|PubMed:11514614, ECO:0000269|PubMed:12499366, ECO:0000269|PubMed:17015472, ECO:0000269|PubMed:17301055, ECO:0000269|PubMed:17460227, ECO:0000269|PubMed:17553808, ECO:0000269|PubMed:18695047, ECO:0000269|PubMed:18838687, ECO:0000269|PubMed:19342591, ECO:0000269|PubMed:19411255, ECO:0000269|PubMed:19638400, ECO:0000269|PubMed:20688057, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:23283981, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:23584531, ECO:0000269|PubMed:23792689, ECO:0000269|PubMed:23921378, ECO:0000269|PubMed:26992161, ECO:0000269|PubMed:27145208, ECO:0000269|PubMed:27145933, ECO:0000269|PubMed:27301544, ECO:0000269|PubMed:27328748, ECO:0000269|PubMed:29478834, ECO:0000269|PubMed:29899447, ECO:0000269|PubMed:32439975, ECO:0000269|PubMed:32484300, ECO:0000269|PubMed:33850055, ECO:0000269|PubMed:9570752, ECO:0000269|PubMed:9786947}.; FUNCTION: [Isoform 1]: Inhibits peroxisomal division when overexpressed. {ECO:0000269|PubMed:12618434}.; FUNCTION: [Isoform 4]: Inhibits peroxisomal division when overexpressed. {ECO:0000269|PubMed:12618434}. |
| Q9GZM8 | NDEL1 | S162 | PSP | Nuclear distribution protein nudE-like 1 (Protein Nudel) (Mitosin-associated protein 1) | Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). Plays a role, together with DISC1, in the regulation of neurite outgrowth (By similarity). May act as a RAB9A/B effector that tethers RAB9-associated late endosomes to the dynein motor for their retrograde transport to the trans-Golgi network (PubMed:34793709). {ECO:0000250|UniProtKB:Q78PB6, ECO:0000250|UniProtKB:Q9ERR1, ECO:0000269|PubMed:12556484, ECO:0000269|PubMed:14970193, ECO:0000269|PubMed:16291865, ECO:0000269|PubMed:17600710, ECO:0000269|PubMed:34793709}. |
| Q9UBC2 | EPS15L1 | S493 | Sugiyama | Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) | Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:9407958}. |
| Q86UE8 | TLK2 | S450 | Sugiyama | Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (HsHPK) (PKU-alpha) (Tousled-like kinase 2) | Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation (PubMed:10523312, PubMed:11470414, PubMed:12660173, PubMed:12955071, PubMed:29955062, PubMed:33323470, PubMed:9427565). Phosphorylates the chromatin assembly factors ASF1A and ASF1B (PubMed:11470414, PubMed:20016786, PubMed:29955062, PubMed:35136069). Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly (PubMed:20016786). Negative regulator of amino acid starvation-induced autophagy (PubMed:22354037). {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:12955071, ECO:0000269|PubMed:20016786, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:29955062, ECO:0000269|PubMed:33323470, ECO:0000269|PubMed:35136069, ECO:0000269|PubMed:9427565}. |
| Q08378 | GOLGA3 | S500 | Sugiyama | Golgin subfamily A member 3 (Golgi complex-associated protein of 170 kDa) (GCP170) (Golgin-160) | Golgi auto-antigen; probably involved in maintaining Golgi structure. |
| P05783 | KRT18 | S86 | Sugiyama | Keratin, type I cytoskeletal 18 (Cell proliferation-inducing gene 46 protein) (Cytokeratin-18) (CK-18) (Keratin-18) (K18) | Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. {ECO:0000250, ECO:0000269|PubMed:15529338, ECO:0000269|PubMed:16424149, ECO:0000269|PubMed:17213200, ECO:0000269|PubMed:7523419, ECO:0000269|PubMed:8522591, ECO:0000269|PubMed:9298992, ECO:0000269|PubMed:9524113}. |
| P43243 | MATR3 | S114 | Sugiyama | Matrin-3 | May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32245947}. |
| Q00610 | CLTC | S432 | Sugiyama | Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17) | Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872). Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilization of the lattice promoting uncoating (By similarity). {ECO:0000250|UniProtKB:P49951, ECO:0000269|PubMed:15858577, ECO:0000269|PubMed:16968737, ECO:0000269|PubMed:20639872, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-6809371 | Formation of the cornified envelope | 1.110223e-16 | 15.955 |
| R-HSA-6805567 | Keratinization | 2.200462e-13 | 12.657 |
| R-HSA-68877 | Mitotic Prometaphase | 7.786612e-09 | 8.109 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 2.028408e-08 | 7.693 |
| R-HSA-1266738 | Developmental Biology | 3.003932e-08 | 7.522 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 5.082428e-08 | 7.294 |
| R-HSA-68886 | M Phase | 1.218271e-07 | 6.914 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 1.435131e-07 | 6.843 |
| R-HSA-9646399 | Aggrephagy | 2.542074e-07 | 6.595 |
| R-HSA-69275 | G2/M Transition | 3.416901e-07 | 6.466 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 3.782223e-07 | 6.422 |
| R-HSA-2132295 | MHC class II antigen presentation | 4.757082e-07 | 6.323 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.156904e-06 | 5.937 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 1.553421e-06 | 5.809 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 1.825163e-06 | 5.739 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 2.263388e-06 | 5.645 |
| R-HSA-9663891 | Selective autophagy | 2.841436e-06 | 5.546 |
| R-HSA-983189 | Kinesins | 2.893473e-06 | 5.539 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 3.751252e-06 | 5.426 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 5.786995e-06 | 5.238 |
| R-HSA-2467813 | Separation of Sister Chromatids | 5.827592e-06 | 5.235 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 6.389937e-06 | 5.195 |
| R-HSA-1640170 | Cell Cycle | 7.056731e-06 | 5.151 |
| R-HSA-190828 | Gap junction trafficking | 7.969696e-06 | 5.099 |
| R-HSA-199991 | Membrane Trafficking | 7.550601e-06 | 5.122 |
| R-HSA-9734767 | Developmental Cell Lineages | 9.144957e-06 | 5.039 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 8.954609e-06 | 5.048 |
| R-HSA-68882 | Mitotic Anaphase | 9.188512e-06 | 5.037 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 9.554514e-06 | 5.020 |
| R-HSA-437239 | Recycling pathway of L1 | 1.091989e-05 | 4.962 |
| R-HSA-157858 | Gap junction trafficking and regulation | 1.333643e-05 | 4.875 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 1.478406e-05 | 4.830 |
| R-HSA-9833482 | PKR-mediated signaling | 1.520056e-05 | 4.818 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 1.696980e-05 | 4.770 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 1.828387e-05 | 4.738 |
| R-HSA-5617833 | Cilium Assembly | 1.901462e-05 | 4.721 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 2.015265e-05 | 4.696 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 2.328563e-05 | 4.633 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 2.817100e-05 | 4.550 |
| R-HSA-9612973 | Autophagy | 2.758917e-05 | 4.559 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 2.834095e-05 | 4.548 |
| R-HSA-390522 | Striated Muscle Contraction | 3.193973e-05 | 4.496 |
| R-HSA-190861 | Gap junction assembly | 3.588319e-05 | 4.445 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 4.504226e-05 | 4.346 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 4.504226e-05 | 4.346 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 4.166572e-05 | 4.380 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 5.200578e-05 | 4.284 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 5.650682e-05 | 4.248 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 5.735004e-05 | 4.241 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 6.536634e-05 | 4.185 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 7.949810e-05 | 4.100 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 8.269778e-05 | 4.083 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 9.242605e-05 | 4.034 |
| R-HSA-1632852 | Macroautophagy | 8.990955e-05 | 4.046 |
| R-HSA-380287 | Centrosome maturation | 1.054678e-04 | 3.977 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 1.225613e-04 | 3.912 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 1.400736e-04 | 3.854 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 1.412553e-04 | 3.850 |
| R-HSA-5653656 | Vesicle-mediated transport | 1.349134e-04 | 3.870 |
| R-HSA-75153 | Apoptotic execution phase | 1.297814e-04 | 3.887 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 1.445347e-04 | 3.840 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 1.593283e-04 | 3.798 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 1.676814e-04 | 3.776 |
| R-HSA-438064 | Post NMDA receptor activation events | 2.300394e-04 | 3.638 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 2.708035e-04 | 3.567 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 2.829066e-04 | 3.548 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 3.515133e-04 | 3.454 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 3.567136e-04 | 3.448 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 3.884355e-04 | 3.411 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 4.133111e-04 | 3.384 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 5.157908e-04 | 3.288 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 5.417664e-04 | 3.266 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 7.298397e-04 | 3.137 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 7.717967e-04 | 3.112 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 8.997961e-04 | 3.046 |
| R-HSA-5357801 | Programmed Cell Death | 9.308196e-04 | 3.031 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 9.343661e-04 | 3.029 |
| R-HSA-373760 | L1CAM interactions | 1.112456e-03 | 2.954 |
| R-HSA-9659379 | Sensory processing of sound | 1.117870e-03 | 2.952 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 1.153932e-03 | 2.938 |
| R-HSA-109581 | Apoptosis | 1.167392e-03 | 2.933 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 1.173731e-03 | 2.930 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 1.421210e-03 | 2.847 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 1.488109e-03 | 2.827 |
| R-HSA-5620924 | Intraflagellar transport | 1.621666e-03 | 2.790 |
| R-HSA-9909396 | Circadian clock | 2.130604e-03 | 2.671 |
| R-HSA-2682334 | EPH-Ephrin signaling | 2.230154e-03 | 2.652 |
| R-HSA-75893 | TNF signaling | 2.620990e-03 | 2.582 |
| R-HSA-5358351 | Signaling by Hedgehog | 2.674869e-03 | 2.573 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 2.730332e-03 | 2.564 |
| R-HSA-9675108 | Nervous system development | 2.754464e-03 | 2.560 |
| R-HSA-5610787 | Hedgehog 'off' state | 3.196937e-03 | 2.495 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 3.251770e-03 | 2.488 |
| R-HSA-9828806 | Maturation of hRSV A proteins | 3.251770e-03 | 2.488 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 3.643995e-03 | 2.438 |
| R-HSA-446107 | Type I hemidesmosome assembly | 4.383935e-03 | 2.358 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 4.383935e-03 | 2.358 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 4.383935e-03 | 2.358 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 4.467783e-03 | 2.350 |
| R-HSA-397014 | Muscle contraction | 4.740729e-03 | 2.324 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 4.807281e-03 | 2.318 |
| R-HSA-422475 | Axon guidance | 4.547138e-03 | 2.342 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 4.740729e-03 | 2.324 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 5.187329e-03 | 2.285 |
| R-HSA-163560 | Triglyceride catabolism | 6.749789e-03 | 2.171 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 6.979877e-03 | 2.156 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 7.185879e-03 | 2.144 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 8.107239e-03 | 2.091 |
| R-HSA-162582 | Signal Transduction | 8.355973e-03 | 2.078 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 9.970712e-03 | 2.001 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 9.970712e-03 | 2.001 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 1.015030e-02 | 1.994 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 1.070264e-02 | 1.971 |
| R-HSA-391251 | Protein folding | 1.310388e-02 | 1.883 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 1.442330e-02 | 1.841 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 1.508766e-02 | 1.821 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 1.646450e-02 | 1.783 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 1.719122e-02 | 1.765 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 1.582408e-02 | 1.801 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 1.719178e-02 | 1.765 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 1.719178e-02 | 1.765 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 1.730769e-02 | 1.762 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 1.789290e-02 | 1.747 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 2.092225e-02 | 1.679 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 2.167887e-02 | 1.664 |
| R-HSA-9700206 | Signaling by ALK in cancer | 2.167887e-02 | 1.664 |
| R-HSA-8979227 | Triglyceride metabolism | 2.193430e-02 | 1.659 |
| R-HSA-379724 | tRNA Aminoacylation | 2.278724e-02 | 1.642 |
| R-HSA-373755 | Semaphorin interactions | 2.545329e-02 | 1.594 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 2.577371e-02 | 1.589 |
| R-HSA-5603027 | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... | 2.611024e-02 | 1.583 |
| R-HSA-5602636 | IKBKB deficiency causes SCID | 2.611024e-02 | 1.583 |
| R-HSA-5602571 | TRAF3 deficiency - HSE | 2.611024e-02 | 1.583 |
| R-HSA-352238 | Breakdown of the nuclear lamina | 2.611024e-02 | 1.583 |
| R-HSA-913531 | Interferon Signaling | 2.745546e-02 | 1.561 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 2.925298e-02 | 1.534 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 3.250535e-02 | 1.488 |
| R-HSA-112315 | Transmission across Chemical Synapses | 3.312260e-02 | 1.480 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 3.479916e-02 | 1.458 |
| R-HSA-264876 | Insulin processing | 3.479916e-02 | 1.458 |
| R-HSA-9615710 | Late endosomal microautophagy | 3.870451e-02 | 1.412 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 4.984854e-02 | 1.302 |
| R-HSA-69620 | Cell Cycle Checkpoints | 3.745156e-02 | 1.427 |
| R-HSA-9609690 | HCMV Early Events | 4.260869e-02 | 1.371 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 4.698349e-02 | 1.328 |
| R-HSA-9020591 | Interleukin-12 signaling | 3.885242e-02 | 1.411 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 4.825593e-02 | 1.316 |
| R-HSA-1280218 | Adaptive Immune System | 5.005730e-02 | 1.301 |
| R-HSA-5673000 | RAF activation | 5.134401e-02 | 1.290 |
| R-HSA-447115 | Interleukin-12 family signaling | 5.381637e-02 | 1.269 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 5.584346e-02 | 1.253 |
| R-HSA-1236974 | ER-Phagosome pathway | 5.654359e-02 | 1.248 |
| R-HSA-111463 | SMAC (DIABLO) binds to IAPs | 5.987370e-02 | 1.223 |
| R-HSA-111464 | SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes | 5.987370e-02 | 1.223 |
| R-HSA-9931529 | Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK | 5.987370e-02 | 1.223 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 6.047571e-02 | 1.218 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 6.283977e-02 | 1.202 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 6.283977e-02 | 1.202 |
| R-HSA-5260271 | Diseases of Immune System | 6.523482e-02 | 1.186 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 6.523482e-02 | 1.186 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 6.523482e-02 | 1.186 |
| R-HSA-73887 | Death Receptor Signaling | 6.674221e-02 | 1.176 |
| R-HSA-168256 | Immune System | 6.736353e-02 | 1.172 |
| R-HSA-111469 | SMAC, XIAP-regulated apoptotic response | 6.813133e-02 | 1.167 |
| R-HSA-111459 | Activation of caspases through apoptosome-mediated cleavage | 6.813133e-02 | 1.167 |
| R-HSA-9842640 | Signaling by LTK in cancer | 7.631695e-02 | 1.117 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 7.631695e-02 | 1.117 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 9.247458e-02 | 1.034 |
| R-HSA-196025 | Formation of annular gap junctions | 9.247458e-02 | 1.034 |
| R-HSA-190873 | Gap junction degradation | 1.004478e-01 | 0.998 |
| R-HSA-9700645 | ALK mutants bind TKIs | 1.004478e-01 | 0.998 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 9.887698e-02 | 1.005 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 1.016349e-01 | 0.993 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 6.813133e-02 | 1.167 |
| R-HSA-68689 | CDC6 association with the ORC:origin complex | 6.813133e-02 | 1.167 |
| R-HSA-114516 | Disinhibition of SNARE formation | 8.443115e-02 | 1.073 |
| R-HSA-68949 | Orc1 removal from chromatin | 9.887698e-02 | 1.005 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 9.614087e-02 | 1.017 |
| R-HSA-8964041 | LDL remodeling | 8.443115e-02 | 1.073 |
| R-HSA-1296052 | Ca2+ activated K+ channels | 8.443115e-02 | 1.073 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 1.004478e-01 | 0.998 |
| R-HSA-6811438 | Intra-Golgi traffic | 7.011501e-02 | 1.154 |
| R-HSA-9667769 | Acetylcholine inhibits contraction of outer hair cells | 6.813133e-02 | 1.167 |
| R-HSA-8948747 | Regulation of PTEN localization | 8.443115e-02 | 1.073 |
| R-HSA-8866423 | VLDL assembly | 7.631695e-02 | 1.117 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 9.614087e-02 | 1.017 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 8.225157e-02 | 1.085 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 9.062296e-02 | 1.043 |
| R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 6.813133e-02 | 1.167 |
| R-HSA-442380 | Zinc influx into cells by the SLC39 gene family | 1.004478e-01 | 0.998 |
| R-HSA-1221632 | Meiotic synapsis | 1.016349e-01 | 0.993 |
| R-HSA-73893 | DNA Damage Bypass | 9.073650e-02 | 1.042 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 9.247458e-02 | 1.034 |
| R-HSA-9020933 | Interleukin-23 signaling | 9.247458e-02 | 1.034 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 9.887698e-02 | 1.005 |
| R-HSA-9609646 | HCMV Infection | 9.179083e-02 | 1.037 |
| R-HSA-112316 | Neuronal System | 6.886791e-02 | 1.162 |
| R-HSA-9824446 | Viral Infection Pathways | 8.222899e-02 | 1.085 |
| R-HSA-9006936 | Signaling by TGFB family members | 7.361661e-02 | 1.133 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 1.239526e-01 | 0.907 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 1.239526e-01 | 0.907 |
| R-HSA-177504 | Retrograde neurotrophin signalling | 1.468475e-01 | 0.833 |
| R-HSA-168275 | Entry of Influenza Virion into Host Cell via Endocytosis | 1.617797e-01 | 0.791 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 1.691481e-01 | 0.772 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 1.691481e-01 | 0.772 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 2.050367e-01 | 0.688 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 1.239526e-01 | 0.907 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 1.691481e-01 | 0.772 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 1.691481e-01 | 0.772 |
| R-HSA-3928664 | Ephrin signaling | 1.836926e-01 | 0.736 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 1.705767e-01 | 0.768 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 1.072138e-01 | 0.970 |
| R-HSA-6798695 | Neutrophil degranulation | 1.311542e-01 | 0.882 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 1.100337e-01 | 0.958 |
| R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 1.083515e-01 | 0.965 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 1.316513e-01 | 0.881 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 1.392827e-01 | 0.856 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 1.543463e-01 | 0.812 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 1.482742e-01 | 0.829 |
| R-HSA-111471 | Apoptotic factor-mediated response | 1.836926e-01 | 0.736 |
| R-HSA-5676594 | TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway | 1.392827e-01 | 0.856 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 1.083515e-01 | 0.965 |
| R-HSA-8963888 | Chylomicron assembly | 1.161863e-01 | 0.935 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 1.617797e-01 | 0.791 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 1.543777e-01 | 0.811 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 1.543777e-01 | 0.811 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 1.543463e-01 | 0.812 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 1.836926e-01 | 0.736 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 1.908698e-01 | 0.719 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 2.050367e-01 | 0.688 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 2.050367e-01 | 0.688 |
| R-HSA-204005 | COPII-mediated vesicle transport | 1.513197e-01 | 0.820 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 1.605294e-01 | 0.794 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 1.918893e-01 | 0.717 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 1.617797e-01 | 0.791 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 1.513197e-01 | 0.820 |
| R-HSA-111461 | Cytochrome c-mediated apoptotic response | 1.239526e-01 | 0.907 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 1.316513e-01 | 0.881 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 1.316513e-01 | 0.881 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 1.468475e-01 | 0.833 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 1.908698e-01 | 0.719 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 1.273436e-01 | 0.895 |
| R-HSA-917937 | Iron uptake and transport | 1.667255e-01 | 0.778 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 2.120275e-01 | 0.674 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 1.836926e-01 | 0.736 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 1.244148e-01 | 0.905 |
| R-HSA-9627069 | Regulation of the apoptosome activity | 1.083515e-01 | 0.965 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 1.392827e-01 | 0.856 |
| R-HSA-5578768 | Physiological factors | 1.468475e-01 | 0.833 |
| R-HSA-209905 | Catecholamine biosynthesis | 1.764523e-01 | 0.753 |
| R-HSA-4086400 | PCP/CE pathway | 1.760959e-01 | 0.754 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 1.684282e-01 | 0.774 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 2.120275e-01 | 0.674 |
| R-HSA-72766 | Translation | 2.076270e-01 | 0.683 |
| R-HSA-9707616 | Heme signaling | 1.273436e-01 | 0.895 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 1.161863e-01 | 0.935 |
| R-HSA-111458 | Formation of apoptosome | 1.083515e-01 | 0.965 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 1.641557e-01 | 0.785 |
| R-HSA-435354 | Zinc transporters | 1.468475e-01 | 0.833 |
| R-HSA-373753 | Nephrin family interactions | 1.979843e-01 | 0.703 |
| R-HSA-5218859 | Regulated Necrosis | 1.452416e-01 | 0.838 |
| R-HSA-9664407 | Parasite infection | 1.620319e-01 | 0.790 |
| R-HSA-9664417 | Leishmania phagocytosis | 1.620319e-01 | 0.790 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 1.620319e-01 | 0.790 |
| R-HSA-1500620 | Meiosis | 1.982592e-01 | 0.703 |
| R-HSA-449836 | Other interleukin signaling | 1.908698e-01 | 0.719 |
| R-HSA-1500931 | Cell-Cell communication | 1.767165e-01 | 0.753 |
| R-HSA-6807070 | PTEN Regulation | 1.599167e-01 | 0.796 |
| R-HSA-1236394 | Signaling by ERBB4 | 1.636221e-01 | 0.786 |
| R-HSA-449147 | Signaling by Interleukins | 2.118974e-01 | 0.674 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 1.362259e-01 | 0.866 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 1.543777e-01 | 0.811 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 2.046548e-01 | 0.689 |
| R-HSA-2262752 | Cellular responses to stress | 2.067304e-01 | 0.685 |
| R-HSA-109582 | Hemostasis | 1.745028e-01 | 0.758 |
| R-HSA-2408522 | Selenoamino acid metabolism | 2.173272e-01 | 0.663 |
| R-HSA-202424 | Downstream TCR signaling | 2.175118e-01 | 0.663 |
| R-HSA-8964038 | LDL clearance | 2.189573e-01 | 0.660 |
| R-HSA-381070 | IRE1alpha activates chaperones | 2.239678e-01 | 0.650 |
| R-HSA-5688426 | Deubiquitination | 2.254694e-01 | 0.647 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 2.272015e-01 | 0.644 |
| R-HSA-8953897 | Cellular responses to stimuli | 2.293097e-01 | 0.640 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 2.304387e-01 | 0.637 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 2.326358e-01 | 0.633 |
| R-HSA-8963898 | Plasma lipoprotein assembly | 2.326358e-01 | 0.633 |
| R-HSA-8863678 | Neurodegenerative Diseases | 2.326358e-01 | 0.633 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 2.326358e-01 | 0.633 |
| R-HSA-1474290 | Collagen formation | 2.336789e-01 | 0.631 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 2.428037e-01 | 0.615 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 2.434153e-01 | 0.614 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 2.460764e-01 | 0.609 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 2.460764e-01 | 0.609 |
| R-HSA-70635 | Urea cycle | 2.460764e-01 | 0.609 |
| R-HSA-5663205 | Infectious disease | 2.499098e-01 | 0.602 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 2.527087e-01 | 0.597 |
| R-HSA-9614085 | FOXO-mediated transcription | 2.531691e-01 | 0.597 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 2.592832e-01 | 0.586 |
| R-HSA-9020702 | Interleukin-1 signaling | 2.596776e-01 | 0.586 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 2.658002e-01 | 0.575 |
| R-HSA-180024 | DARPP-32 events | 2.658002e-01 | 0.575 |
| R-HSA-446728 | Cell junction organization | 2.692966e-01 | 0.570 |
| R-HSA-68962 | Activation of the pre-replicative complex | 2.722602e-01 | 0.565 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 2.722602e-01 | 0.565 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 2.759542e-01 | 0.559 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 2.786639e-01 | 0.555 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 2.786639e-01 | 0.555 |
| R-HSA-182971 | EGFR downregulation | 2.786639e-01 | 0.555 |
| R-HSA-399719 | Trafficking of AMPA receptors | 2.786639e-01 | 0.555 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 2.786639e-01 | 0.555 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 2.792085e-01 | 0.554 |
| R-HSA-69239 | Synthesis of DNA | 2.824618e-01 | 0.549 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 2.850115e-01 | 0.545 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 2.853425e-01 | 0.545 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 2.889648e-01 | 0.539 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 2.907905e-01 | 0.536 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 2.913037e-01 | 0.536 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 2.913037e-01 | 0.536 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 2.913037e-01 | 0.536 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 2.922139e-01 | 0.534 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 2.922139e-01 | 0.534 |
| R-HSA-202403 | TCR signaling | 2.922139e-01 | 0.534 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 2.975409e-01 | 0.526 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 2.975409e-01 | 0.526 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 2.975409e-01 | 0.526 |
| R-HSA-168249 | Innate Immune System | 3.032387e-01 | 0.518 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 3.037236e-01 | 0.518 |
| R-HSA-5696400 | Dual Incision in GG-NER | 3.037236e-01 | 0.518 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 3.037236e-01 | 0.518 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 3.037236e-01 | 0.518 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 3.037236e-01 | 0.518 |
| R-HSA-5205647 | Mitophagy | 3.037236e-01 | 0.518 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 3.037236e-01 | 0.518 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 3.037236e-01 | 0.518 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 3.045939e-01 | 0.516 |
| R-HSA-917977 | Transferrin endocytosis and recycling | 3.098523e-01 | 0.509 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 3.098523e-01 | 0.509 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 3.098523e-01 | 0.509 |
| R-HSA-169911 | Regulation of Apoptosis | 3.098523e-01 | 0.509 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 3.098523e-01 | 0.509 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 3.159274e-01 | 0.500 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 3.159274e-01 | 0.500 |
| R-HSA-9682385 | FLT3 signaling in disease | 3.159274e-01 | 0.500 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 3.159274e-01 | 0.500 |
| R-HSA-2980736 | Peptide hormone metabolism | 3.213489e-01 | 0.493 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 3.219494e-01 | 0.492 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 3.219494e-01 | 0.492 |
| R-HSA-4641258 | Degradation of DVL | 3.219494e-01 | 0.492 |
| R-HSA-4641257 | Degradation of AXIN | 3.219494e-01 | 0.492 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 3.219494e-01 | 0.492 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 3.219494e-01 | 0.492 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 3.269421e-01 | 0.486 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 3.277882e-01 | 0.484 |
| R-HSA-8875878 | MET promotes cell motility | 3.279187e-01 | 0.484 |
| R-HSA-68875 | Mitotic Prophase | 3.310019e-01 | 0.480 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 3.338359e-01 | 0.476 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 3.338359e-01 | 0.476 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 3.338359e-01 | 0.476 |
| R-HSA-69541 | Stabilization of p53 | 3.338359e-01 | 0.476 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 3.338359e-01 | 0.476 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 3.397013e-01 | 0.469 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 3.397013e-01 | 0.469 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 3.397013e-01 | 0.469 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 3.455154e-01 | 0.462 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 3.455154e-01 | 0.462 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 3.455154e-01 | 0.462 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 3.455154e-01 | 0.462 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 3.455154e-01 | 0.462 |
| R-HSA-5423646 | Aflatoxin activation and detoxification | 3.455154e-01 | 0.462 |
| R-HSA-69206 | G1/S Transition | 3.501903e-01 | 0.456 |
| R-HSA-5674135 | MAP2K and MAPK activation | 3.512787e-01 | 0.454 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 3.512787e-01 | 0.454 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 3.512787e-01 | 0.454 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 3.512787e-01 | 0.454 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 3.512787e-01 | 0.454 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 3.512787e-01 | 0.454 |
| R-HSA-69481 | G2/M Checkpoints | 3.565467e-01 | 0.448 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 3.569917e-01 | 0.447 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 3.626546e-01 | 0.441 |
| R-HSA-9907900 | Proteasome assembly | 3.682680e-01 | 0.434 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 3.682680e-01 | 0.434 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 3.682680e-01 | 0.434 |
| R-HSA-373752 | Netrin-1 signaling | 3.682680e-01 | 0.434 |
| R-HSA-1474165 | Reproduction | 3.691925e-01 | 0.433 |
| R-HSA-5576891 | Cardiac conduction | 3.723392e-01 | 0.429 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 3.738324e-01 | 0.427 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 3.738324e-01 | 0.427 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 3.738324e-01 | 0.427 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 3.738324e-01 | 0.427 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 3.738324e-01 | 0.427 |
| R-HSA-9824272 | Somitogenesis | 3.738324e-01 | 0.427 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 3.741633e-01 | 0.427 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 3.786138e-01 | 0.422 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 3.793480e-01 | 0.421 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 3.793480e-01 | 0.421 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 3.793480e-01 | 0.421 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 3.793480e-01 | 0.421 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 3.793480e-01 | 0.421 |
| R-HSA-6802949 | Signaling by RAS mutants | 3.793480e-01 | 0.421 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 3.848154e-01 | 0.415 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 3.848154e-01 | 0.415 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 3.848154e-01 | 0.415 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 3.848154e-01 | 0.415 |
| R-HSA-425410 | Metal ion SLC transporters | 3.902350e-01 | 0.409 |
| R-HSA-8963899 | Plasma lipoprotein remodeling | 3.902350e-01 | 0.409 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 3.910844e-01 | 0.408 |
| R-HSA-9766229 | Degradation of CDH1 | 3.956072e-01 | 0.403 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 3.956072e-01 | 0.403 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 3.956072e-01 | 0.403 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 4.003647e-01 | 0.398 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 4.009324e-01 | 0.397 |
| R-HSA-5683057 | MAPK family signaling cascades | 4.061488e-01 | 0.391 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 4.062110e-01 | 0.391 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 4.114434e-01 | 0.386 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 4.114434e-01 | 0.386 |
| R-HSA-6794361 | Neurexins and neuroligins | 4.114434e-01 | 0.386 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 4.166300e-01 | 0.380 |
| R-HSA-445355 | Smooth Muscle Contraction | 4.166300e-01 | 0.380 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 4.187254e-01 | 0.378 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 4.217712e-01 | 0.375 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 4.247833e-01 | 0.372 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 4.308088e-01 | 0.366 |
| R-HSA-69242 | S Phase | 4.308088e-01 | 0.366 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 4.319191e-01 | 0.365 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 4.319191e-01 | 0.365 |
| R-HSA-177929 | Signaling by EGFR | 4.319191e-01 | 0.365 |
| R-HSA-5578775 | Ion homeostasis | 4.319191e-01 | 0.365 |
| R-HSA-209776 | Metabolism of amine-derived hormones | 4.319191e-01 | 0.365 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 4.319191e-01 | 0.365 |
| R-HSA-9679191 | Potential therapeutics for SARS | 4.368011e-01 | 0.360 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 4.369265e-01 | 0.360 |
| R-HSA-9764561 | Regulation of CDH1 Function | 4.369265e-01 | 0.360 |
| R-HSA-6782135 | Dual incision in TC-NER | 4.418901e-01 | 0.355 |
| R-HSA-446652 | Interleukin-1 family signaling | 4.427595e-01 | 0.354 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 4.427595e-01 | 0.354 |
| R-HSA-69306 | DNA Replication | 4.457258e-01 | 0.351 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 4.468102e-01 | 0.350 |
| R-HSA-351202 | Metabolism of polyamines | 4.516873e-01 | 0.345 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 4.516873e-01 | 0.345 |
| R-HSA-1227986 | Signaling by ERBB2 | 4.516873e-01 | 0.345 |
| R-HSA-450294 | MAP kinase activation | 4.565216e-01 | 0.341 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 4.565216e-01 | 0.341 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 4.604253e-01 | 0.337 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 4.613137e-01 | 0.336 |
| R-HSA-877300 | Interferon gamma signaling | 4.633382e-01 | 0.334 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 4.660638e-01 | 0.332 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 4.707723e-01 | 0.327 |
| R-HSA-936837 | Ion transport by P-type ATPases | 4.707723e-01 | 0.327 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 4.754395e-01 | 0.323 |
| R-HSA-1234174 | Cellular response to hypoxia | 4.754395e-01 | 0.323 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 4.800659e-01 | 0.319 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 4.891975e-01 | 0.311 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 4.962146e-01 | 0.304 |
| R-HSA-9658195 | Leishmania infection | 4.966419e-01 | 0.304 |
| R-HSA-9824443 | Parasitic Infection Pathways | 4.966419e-01 | 0.304 |
| R-HSA-448424 | Interleukin-17 signaling | 4.981698e-01 | 0.303 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 4.981698e-01 | 0.303 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 4.981698e-01 | 0.303 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 4.981698e-01 | 0.303 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 4.981698e-01 | 0.303 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 4.988472e-01 | 0.302 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 5.003537e-01 | 0.301 |
| R-HSA-5632684 | Hedgehog 'on' state | 5.025971e-01 | 0.299 |
| R-HSA-5689880 | Ub-specific processing proteases | 5.059034e-01 | 0.296 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 5.059034e-01 | 0.296 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 5.059034e-01 | 0.296 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 5.069856e-01 | 0.295 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 5.069856e-01 | 0.295 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 5.114135e-01 | 0.291 |
| R-HSA-9013694 | Signaling by NOTCH4 | 5.156475e-01 | 0.288 |
| R-HSA-597592 | Post-translational protein modification | 5.199194e-01 | 0.284 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 5.199217e-01 | 0.284 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 5.199217e-01 | 0.284 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 5.199217e-01 | 0.284 |
| R-HSA-5689603 | UCH proteinases | 5.241584e-01 | 0.281 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 5.270676e-01 | 0.278 |
| R-HSA-416482 | G alpha (12/13) signalling events | 5.325208e-01 | 0.274 |
| R-HSA-5619084 | ABC transporter disorders | 5.325208e-01 | 0.274 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 5.330505e-01 | 0.273 |
| R-HSA-195721 | Signaling by WNT | 5.334567e-01 | 0.273 |
| R-HSA-6806834 | Signaling by MET | 5.407372e-01 | 0.267 |
| R-HSA-168898 | Toll-like Receptor Cascades | 5.540310e-01 | 0.256 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 5.566067e-01 | 0.254 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 5.567422e-01 | 0.254 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 5.567422e-01 | 0.254 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 5.606562e-01 | 0.251 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 5.606562e-01 | 0.251 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 5.645358e-01 | 0.248 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 5.668050e-01 | 0.247 |
| R-HSA-392499 | Metabolism of proteins | 5.758117e-01 | 0.240 |
| R-HSA-9645723 | Diseases of programmed cell death | 5.759718e-01 | 0.240 |
| R-HSA-9679506 | SARS-CoV Infections | 5.767094e-01 | 0.239 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 5.842466e-01 | 0.233 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 5.943727e-01 | 0.226 |
| R-HSA-1474244 | Extracellular matrix organization | 6.004151e-01 | 0.222 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 6.085207e-01 | 0.216 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 6.106071e-01 | 0.214 |
| R-HSA-1296071 | Potassium Channels | 6.119805e-01 | 0.213 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 6.154099e-01 | 0.211 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 6.188092e-01 | 0.208 |
| R-HSA-5368286 | Mitochondrial translation initiation | 6.188092e-01 | 0.208 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 6.188092e-01 | 0.208 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 6.188092e-01 | 0.208 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 6.188092e-01 | 0.208 |
| R-HSA-422356 | Regulation of insulin secretion | 6.188092e-01 | 0.208 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 6.213042e-01 | 0.207 |
| R-HSA-418990 | Adherens junctions interactions | 6.221655e-01 | 0.206 |
| R-HSA-382556 | ABC-family proteins mediated transport | 6.255185e-01 | 0.204 |
| R-HSA-2408557 | Selenocysteine synthesis | 6.288291e-01 | 0.201 |
| R-HSA-8951664 | Neddylation | 6.289737e-01 | 0.201 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 6.321106e-01 | 0.199 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 6.342098e-01 | 0.198 |
| R-HSA-1643685 | Disease | 6.351201e-01 | 0.197 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 6.385875e-01 | 0.195 |
| R-HSA-111885 | Opioid Signalling | 6.385875e-01 | 0.195 |
| R-HSA-9833110 | RSV-host interactions | 6.417833e-01 | 0.193 |
| R-HSA-5696398 | Nucleotide Excision Repair | 6.449511e-01 | 0.190 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 6.542884e-01 | 0.184 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 6.573464e-01 | 0.182 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 6.693119e-01 | 0.174 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 6.722378e-01 | 0.172 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 6.751381e-01 | 0.171 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 6.780129e-01 | 0.169 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 6.808624e-01 | 0.167 |
| R-HSA-421270 | Cell-cell junction organization | 6.918995e-01 | 0.160 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 6.920122e-01 | 0.160 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 6.920122e-01 | 0.160 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 6.974412e-01 | 0.156 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 7.001199e-01 | 0.155 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 7.001199e-01 | 0.155 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 7.027751e-01 | 0.153 |
| R-HSA-162909 | Host Interactions of HIV factors | 7.054070e-01 | 0.152 |
| R-HSA-194138 | Signaling by VEGF | 7.106015e-01 | 0.148 |
| R-HSA-114608 | Platelet degranulation | 7.157050e-01 | 0.145 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 7.182231e-01 | 0.144 |
| R-HSA-9711123 | Cellular response to chemical stress | 7.235228e-01 | 0.141 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 7.340170e-01 | 0.134 |
| R-HSA-163685 | Integration of energy metabolism | 7.422177e-01 | 0.129 |
| R-HSA-5368287 | Mitochondrial translation | 7.467674e-01 | 0.127 |
| R-HSA-9948299 | Ribosome-associated quality control | 7.467674e-01 | 0.127 |
| R-HSA-166520 | Signaling by NTRKs | 7.704017e-01 | 0.113 |
| R-HSA-9758941 | Gastrulation | 7.724384e-01 | 0.112 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 7.764582e-01 | 0.110 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 7.784415e-01 | 0.109 |
| R-HSA-1989781 | PPARA activates gene expression | 7.842874e-01 | 0.106 |
| R-HSA-382551 | Transport of small molecules | 7.865861e-01 | 0.104 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 7.880993e-01 | 0.103 |
| R-HSA-5633007 | Regulation of TP53 Activity | 7.936920e-01 | 0.100 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 8.129733e-01 | 0.090 |
| R-HSA-72306 | tRNA processing | 8.129733e-01 | 0.090 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 8.162816e-01 | 0.088 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 8.179138e-01 | 0.087 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 8.179138e-01 | 0.087 |
| R-HSA-168255 | Influenza Infection | 8.274094e-01 | 0.082 |
| R-HSA-2559583 | Cellular Senescence | 8.289435e-01 | 0.081 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 8.407385e-01 | 0.075 |
| R-HSA-983712 | Ion channel transport | 8.421549e-01 | 0.075 |
| R-HSA-73894 | DNA Repair | 8.507702e-01 | 0.070 |
| R-HSA-389948 | Co-inhibition by PD-1 | 8.569334e-01 | 0.067 |
| R-HSA-376176 | Signaling by ROBO receptors | 8.607198e-01 | 0.065 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 8.876376e-01 | 0.052 |
| R-HSA-162906 | HIV Infection | 8.886393e-01 | 0.051 |
| R-HSA-72312 | rRNA processing | 8.935166e-01 | 0.049 |
| R-HSA-157118 | Signaling by NOTCH | 9.008827e-01 | 0.045 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 9.069116e-01 | 0.042 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 9.141309e-01 | 0.039 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 9.529870e-01 | 0.021 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.761198e-01 | 0.010 |
| R-HSA-418594 | G alpha (i) signalling events | 9.781874e-01 | 0.010 |
| R-HSA-8953854 | Metabolism of RNA | 9.826557e-01 | 0.008 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 9.871147e-01 | 0.006 |
| R-HSA-9709957 | Sensory Perception | 9.883819e-01 | 0.005 |
| R-HSA-211859 | Biological oxidations | 9.924031e-01 | 0.003 |
| R-HSA-388396 | GPCR downstream signalling | 9.936814e-01 | 0.003 |
| R-HSA-212436 | Generic Transcription Pathway | 9.955935e-01 | 0.002 |
| R-HSA-372790 | Signaling by GPCR | 9.967964e-01 | 0.001 |
| R-HSA-73857 | RNA Polymerase II Transcription | 9.982952e-01 | 0.001 |
| R-HSA-74160 | Gene expression (Transcription) | 9.991691e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.994535e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999991e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.808 | 0.159 | 2 | 0.836 |
PKN3 |
0.801 | 0.189 | -3 | 0.758 |
RAF1 |
0.800 | 0.193 | 1 | 0.857 |
TBK1 |
0.799 | 0.184 | 1 | 0.848 |
ULK2 |
0.797 | 0.082 | 2 | 0.768 |
MST4 |
0.797 | 0.154 | 2 | 0.816 |
IKKB |
0.795 | 0.115 | -2 | 0.776 |
AMPKA1 |
0.795 | 0.174 | -3 | 0.799 |
DSTYK |
0.795 | 0.088 | 2 | 0.818 |
IKKE |
0.794 | 0.147 | 1 | 0.851 |
PKCD |
0.793 | 0.156 | 2 | 0.788 |
NUAK2 |
0.793 | 0.135 | -3 | 0.804 |
AMPKA2 |
0.792 | 0.165 | -3 | 0.785 |
PRKD2 |
0.792 | 0.113 | -3 | 0.753 |
PKN2 |
0.792 | 0.143 | -3 | 0.786 |
TSSK1 |
0.792 | 0.168 | -3 | 0.813 |
NIM1 |
0.792 | 0.117 | 3 | 0.706 |
ULK1 |
0.792 | 0.057 | -3 | 0.680 |
NUAK1 |
0.790 | 0.134 | -3 | 0.780 |
TSSK2 |
0.790 | 0.137 | -5 | 0.748 |
IKKA |
0.790 | 0.146 | -2 | 0.752 |
MARK4 |
0.790 | 0.122 | 4 | 0.774 |
PRKD1 |
0.789 | 0.080 | -3 | 0.740 |
SIK |
0.789 | 0.153 | -3 | 0.747 |
HUNK |
0.789 | 0.123 | 2 | 0.750 |
MTOR |
0.788 | 0.014 | 1 | 0.792 |
MELK |
0.788 | 0.146 | -3 | 0.778 |
CAMK1B |
0.787 | 0.069 | -3 | 0.808 |
GCN2 |
0.787 | -0.045 | 2 | 0.725 |
CDC7 |
0.787 | 0.024 | 1 | 0.727 |
RSK2 |
0.787 | 0.068 | -3 | 0.745 |
WNK1 |
0.786 | 0.089 | -2 | 0.790 |
PIM3 |
0.786 | 0.049 | -3 | 0.766 |
NEK7 |
0.785 | 0.029 | -3 | 0.695 |
QSK |
0.785 | 0.132 | 4 | 0.747 |
NEK6 |
0.785 | 0.040 | -2 | 0.770 |
NIK |
0.785 | 0.120 | -3 | 0.809 |
CLK3 |
0.785 | 0.078 | 1 | 0.674 |
MAPKAPK3 |
0.785 | 0.073 | -3 | 0.738 |
PDHK1 |
0.784 | 0.068 | 1 | 0.858 |
BCKDK |
0.784 | 0.104 | -1 | 0.701 |
PRPK |
0.784 | -0.062 | -1 | 0.685 |
CAMK2G |
0.783 | 0.040 | 2 | 0.684 |
PIM1 |
0.783 | 0.090 | -3 | 0.746 |
RSK3 |
0.782 | 0.047 | -3 | 0.738 |
MARK2 |
0.782 | 0.152 | 4 | 0.697 |
MAPKAPK2 |
0.782 | 0.091 | -3 | 0.709 |
P70S6KB |
0.782 | 0.059 | -3 | 0.768 |
P90RSK |
0.781 | 0.039 | -3 | 0.727 |
PHKG2 |
0.781 | 0.157 | -3 | 0.808 |
MARK3 |
0.781 | 0.136 | 4 | 0.729 |
MLK1 |
0.781 | 0.029 | 2 | 0.805 |
PDHK4 |
0.780 | -0.077 | 1 | 0.835 |
QIK |
0.780 | 0.093 | -3 | 0.775 |
WNK3 |
0.780 | 0.018 | 1 | 0.820 |
CAMK4 |
0.780 | 0.087 | -3 | 0.790 |
CAMK2D |
0.780 | 0.060 | -3 | 0.769 |
PKCB |
0.780 | 0.100 | 2 | 0.762 |
MARK1 |
0.780 | 0.158 | 4 | 0.737 |
NLK |
0.779 | -0.008 | 1 | 0.726 |
CDKL1 |
0.779 | 0.019 | -3 | 0.732 |
NEK9 |
0.778 | 0.020 | 2 | 0.815 |
NDR1 |
0.778 | 0.007 | -3 | 0.782 |
ATR |
0.777 | 0.012 | 1 | 0.781 |
CHK1 |
0.777 | 0.115 | -3 | 0.791 |
PRKD3 |
0.777 | 0.062 | -3 | 0.734 |
GRK6 |
0.777 | 0.077 | 1 | 0.783 |
SGK3 |
0.777 | 0.119 | -3 | 0.733 |
PKCH |
0.777 | 0.097 | 2 | 0.748 |
LATS2 |
0.777 | 0.037 | -5 | 0.704 |
NDR2 |
0.776 | -0.009 | -3 | 0.765 |
PHKG1 |
0.776 | 0.096 | -3 | 0.781 |
BRSK1 |
0.776 | 0.105 | -3 | 0.765 |
PKACG |
0.775 | 0.044 | -2 | 0.653 |
CAMK2B |
0.775 | 0.094 | 2 | 0.639 |
PKCA |
0.775 | 0.089 | 2 | 0.751 |
PLK1 |
0.775 | 0.090 | -2 | 0.738 |
LATS1 |
0.775 | 0.101 | -3 | 0.776 |
MNK2 |
0.775 | 0.054 | -2 | 0.704 |
CHAK2 |
0.774 | -0.023 | -1 | 0.698 |
PKCG |
0.774 | 0.075 | 2 | 0.743 |
BMPR2 |
0.774 | -0.162 | -2 | 0.811 |
YSK4 |
0.774 | 0.091 | 1 | 0.831 |
MOS |
0.774 | -0.068 | 1 | 0.728 |
NEK2 |
0.774 | 0.052 | 2 | 0.789 |
BRAF |
0.773 | 0.161 | -4 | 0.713 |
RIPK3 |
0.773 | -0.043 | 3 | 0.600 |
PAK6 |
0.773 | 0.075 | -2 | 0.652 |
IRE2 |
0.773 | 0.034 | 2 | 0.785 |
MNK1 |
0.773 | 0.077 | -2 | 0.719 |
TGFBR2 |
0.772 | -0.056 | -2 | 0.677 |
SSTK |
0.772 | 0.119 | 4 | 0.735 |
BRSK2 |
0.772 | 0.061 | -3 | 0.784 |
AKT2 |
0.772 | 0.074 | -3 | 0.691 |
MLK3 |
0.772 | 0.046 | 2 | 0.745 |
PKCZ |
0.771 | 0.062 | 2 | 0.782 |
FAM20C |
0.771 | 0.081 | 2 | 0.537 |
CAMLCK |
0.771 | -0.024 | -2 | 0.766 |
PLK3 |
0.771 | 0.103 | 2 | 0.662 |
DLK |
0.771 | -0.016 | 1 | 0.823 |
AKT1 |
0.771 | 0.098 | -3 | 0.708 |
SKMLCK |
0.771 | 0.018 | -2 | 0.735 |
ANKRD3 |
0.771 | 0.005 | 1 | 0.846 |
MLK2 |
0.770 | -0.020 | 2 | 0.788 |
PAK1 |
0.770 | 0.023 | -2 | 0.678 |
IRE1 |
0.770 | -0.013 | 1 | 0.708 |
MLK4 |
0.770 | 0.046 | 2 | 0.728 |
CAMK2A |
0.770 | 0.060 | 2 | 0.640 |
DNAPK |
0.769 | 0.083 | 1 | 0.808 |
SRPK2 |
0.769 | 0.032 | -3 | 0.647 |
RSK4 |
0.769 | 0.051 | -3 | 0.707 |
SRPK1 |
0.769 | 0.014 | -3 | 0.699 |
PKCT |
0.769 | 0.086 | 2 | 0.758 |
PAK3 |
0.769 | 0.001 | -2 | 0.702 |
DAPK2 |
0.769 | -0.030 | -3 | 0.793 |
MSK2 |
0.769 | 0.002 | -3 | 0.681 |
GRK5 |
0.768 | -0.084 | -3 | 0.731 |
ERK5 |
0.768 | -0.046 | 1 | 0.619 |
DCAMKL1 |
0.768 | 0.107 | -3 | 0.783 |
GRK1 |
0.768 | 0.021 | -2 | 0.709 |
CDKL5 |
0.768 | -0.015 | -3 | 0.721 |
ATM |
0.768 | 0.018 | 1 | 0.756 |
CLK1 |
0.767 | 0.053 | -3 | 0.756 |
MASTL |
0.767 | -0.104 | -2 | 0.781 |
PKR |
0.767 | 0.036 | 1 | 0.760 |
PKACB |
0.767 | 0.053 | -2 | 0.570 |
CHAK1 |
0.766 | -0.013 | 2 | 0.728 |
PKN1 |
0.766 | 0.115 | -3 | 0.719 |
ICK |
0.765 | -0.020 | -3 | 0.754 |
PLK4 |
0.765 | 0.055 | 2 | 0.600 |
TAO3 |
0.764 | 0.148 | 1 | 0.813 |
DCAMKL2 |
0.764 | 0.098 | -3 | 0.812 |
AURC |
0.764 | 0.006 | -2 | 0.547 |
ZAK |
0.764 | 0.051 | 1 | 0.841 |
CAMK1G |
0.763 | 0.024 | -3 | 0.743 |
SNRK |
0.763 | -0.035 | 2 | 0.657 |
PRKX |
0.762 | 0.082 | -3 | 0.696 |
P70S6K |
0.762 | 0.037 | -3 | 0.690 |
PKG2 |
0.762 | 0.030 | -2 | 0.589 |
TTBK2 |
0.762 | -0.101 | 2 | 0.669 |
GRK7 |
0.762 | 0.044 | 1 | 0.720 |
MEK1 |
0.762 | -0.035 | 2 | 0.762 |
CAMK1D |
0.762 | 0.080 | -3 | 0.705 |
PKCI |
0.761 | 0.059 | 2 | 0.760 |
HIPK4 |
0.761 | -0.050 | 1 | 0.648 |
PIM2 |
0.760 | 0.037 | -3 | 0.732 |
MSK1 |
0.760 | 0.007 | -3 | 0.697 |
GRK4 |
0.760 | -0.068 | -2 | 0.715 |
WNK4 |
0.760 | 0.020 | -2 | 0.784 |
MST3 |
0.760 | 0.090 | 2 | 0.803 |
CLK4 |
0.760 | 0.013 | -3 | 0.751 |
RIPK1 |
0.760 | -0.138 | 1 | 0.797 |
AURB |
0.759 | -0.003 | -2 | 0.547 |
CDK2 |
0.759 | 0.005 | 1 | 0.573 |
CDK5 |
0.759 | -0.002 | 1 | 0.533 |
ALK4 |
0.757 | -0.048 | -2 | 0.725 |
IRAK4 |
0.757 | 0.001 | 1 | 0.749 |
PAK2 |
0.757 | -0.031 | -2 | 0.672 |
MEKK1 |
0.757 | -0.010 | 1 | 0.823 |
JNK2 |
0.757 | 0.015 | 1 | 0.500 |
PKCE |
0.757 | 0.085 | 2 | 0.738 |
TAO2 |
0.757 | 0.109 | 2 | 0.825 |
CDK8 |
0.757 | -0.058 | 1 | 0.543 |
TGFBR1 |
0.757 | -0.015 | -2 | 0.693 |
PKACA |
0.756 | 0.049 | -2 | 0.528 |
SRPK3 |
0.756 | -0.009 | -3 | 0.670 |
DRAK1 |
0.756 | -0.022 | 1 | 0.766 |
BMPR1B |
0.756 | 0.008 | 1 | 0.666 |
KIS |
0.756 | -0.048 | 1 | 0.556 |
MYLK4 |
0.756 | -0.018 | -2 | 0.673 |
CAMK1A |
0.755 | 0.075 | -3 | 0.680 |
MAPKAPK5 |
0.755 | -0.054 | -3 | 0.666 |
MEKK3 |
0.755 | -0.036 | 1 | 0.814 |
AKT3 |
0.755 | 0.063 | -3 | 0.625 |
MEKK2 |
0.754 | 0.015 | 2 | 0.777 |
NEK5 |
0.754 | 0.006 | 1 | 0.790 |
CAMKK1 |
0.754 | 0.056 | -2 | 0.820 |
AURA |
0.754 | -0.003 | -2 | 0.502 |
SGK1 |
0.753 | 0.075 | -3 | 0.614 |
TLK2 |
0.753 | -0.040 | 1 | 0.792 |
HRI |
0.753 | -0.097 | -2 | 0.773 |
MST2 |
0.753 | 0.106 | 1 | 0.827 |
NEK8 |
0.752 | 0.034 | 2 | 0.802 |
CLK2 |
0.752 | 0.035 | -3 | 0.739 |
JNK3 |
0.752 | -0.006 | 1 | 0.529 |
TNIK |
0.752 | 0.144 | 3 | 0.767 |
LOK |
0.752 | 0.106 | -2 | 0.780 |
CAMKK2 |
0.752 | 0.063 | -2 | 0.820 |
VRK2 |
0.752 | -0.187 | 1 | 0.792 |
CDK1 |
0.752 | -0.017 | 1 | 0.480 |
MINK |
0.752 | 0.141 | 1 | 0.840 |
PERK |
0.752 | -0.102 | -2 | 0.777 |
MEK5 |
0.751 | -0.088 | 2 | 0.780 |
DYRK2 |
0.751 | -0.040 | 1 | 0.547 |
PAK5 |
0.751 | 0.014 | -2 | 0.553 |
CDK19 |
0.751 | -0.060 | 1 | 0.501 |
HGK |
0.750 | 0.100 | 3 | 0.746 |
PINK1 |
0.750 | -0.090 | 1 | 0.678 |
CHK2 |
0.750 | 0.053 | -3 | 0.668 |
SMG1 |
0.749 | -0.064 | 1 | 0.744 |
NEK4 |
0.749 | 0.056 | 1 | 0.808 |
PLK2 |
0.748 | 0.102 | -3 | 0.747 |
NEK11 |
0.748 | 0.013 | 1 | 0.856 |
MST1 |
0.748 | 0.105 | 1 | 0.827 |
IRAK1 |
0.748 | -0.068 | -1 | 0.573 |
EEF2K |
0.748 | 0.053 | 3 | 0.756 |
ALK2 |
0.747 | -0.044 | -2 | 0.702 |
ACVR2A |
0.747 | -0.073 | -2 | 0.695 |
CDK3 |
0.747 | 0.019 | 1 | 0.417 |
ACVR2B |
0.747 | -0.070 | -2 | 0.710 |
GCK |
0.747 | 0.103 | 1 | 0.825 |
PDK1 |
0.746 | 0.081 | 1 | 0.860 |
KHS1 |
0.746 | 0.149 | 1 | 0.842 |
CDK7 |
0.746 | -0.086 | 1 | 0.529 |
KHS2 |
0.746 | 0.154 | 1 | 0.844 |
ERK2 |
0.746 | -0.046 | 1 | 0.526 |
CDK16 |
0.746 | 0.001 | 1 | 0.420 |
DYRK1A |
0.745 | -0.022 | 1 | 0.614 |
SMMLCK |
0.745 | -0.035 | -3 | 0.767 |
MRCKA |
0.745 | 0.056 | -3 | 0.751 |
P38A |
0.745 | -0.050 | 1 | 0.543 |
SLK |
0.745 | 0.070 | -2 | 0.713 |
P38G |
0.745 | -0.026 | 1 | 0.408 |
CDK18 |
0.745 | -0.046 | 1 | 0.448 |
MRCKB |
0.744 | 0.051 | -3 | 0.735 |
TAK1 |
0.744 | 0.073 | 1 | 0.850 |
YSK1 |
0.743 | 0.069 | 2 | 0.796 |
BMPR1A |
0.743 | 0.007 | 1 | 0.664 |
MAP3K15 |
0.743 | 0.030 | 1 | 0.836 |
CDK13 |
0.743 | -0.079 | 1 | 0.510 |
HIPK1 |
0.743 | -0.026 | 1 | 0.562 |
HPK1 |
0.742 | 0.089 | 1 | 0.836 |
LKB1 |
0.742 | -0.002 | -3 | 0.697 |
PRP4 |
0.742 | -0.051 | -3 | 0.617 |
ERK1 |
0.742 | -0.048 | 1 | 0.477 |
SBK |
0.742 | 0.043 | -3 | 0.610 |
PAK4 |
0.742 | -0.003 | -2 | 0.546 |
CDK9 |
0.742 | -0.077 | 1 | 0.524 |
NEK1 |
0.741 | 0.039 | 1 | 0.788 |
TLK1 |
0.741 | -0.105 | -2 | 0.707 |
P38B |
0.741 | -0.037 | 1 | 0.475 |
MEKK6 |
0.741 | -0.016 | 1 | 0.780 |
P38D |
0.741 | -0.004 | 1 | 0.424 |
TTBK1 |
0.741 | -0.102 | 2 | 0.588 |
ROCK2 |
0.740 | 0.065 | -3 | 0.757 |
CDK17 |
0.740 | -0.053 | 1 | 0.410 |
GRK2 |
0.739 | -0.088 | -2 | 0.618 |
HIPK2 |
0.739 | -0.027 | 1 | 0.456 |
CDK14 |
0.739 | -0.042 | 1 | 0.507 |
RIPK2 |
0.738 | -0.066 | 1 | 0.839 |
PASK |
0.738 | -0.050 | -3 | 0.755 |
ERK7 |
0.737 | 0.005 | 2 | 0.555 |
DAPK3 |
0.737 | -0.001 | -3 | 0.773 |
LRRK2 |
0.737 | -0.027 | 2 | 0.802 |
HIPK3 |
0.736 | -0.056 | 1 | 0.591 |
TAO1 |
0.736 | 0.094 | 1 | 0.805 |
CDK12 |
0.736 | -0.083 | 1 | 0.495 |
DYRK1B |
0.736 | -0.040 | 1 | 0.496 |
CDK10 |
0.735 | -0.028 | 1 | 0.485 |
GSK3B |
0.735 | -0.045 | 4 | 0.404 |
CDK4 |
0.735 | -0.022 | 1 | 0.477 |
CDK6 |
0.734 | -0.022 | 1 | 0.488 |
NEK3 |
0.734 | -0.030 | 1 | 0.797 |
ROCK1 |
0.733 | 0.057 | -3 | 0.746 |
GAK |
0.733 | -0.067 | 1 | 0.688 |
CK2A2 |
0.732 | 0.018 | 1 | 0.543 |
DYRK3 |
0.732 | -0.045 | 1 | 0.573 |
PKG1 |
0.732 | 0.009 | -2 | 0.525 |
MEK2 |
0.732 | -0.076 | 2 | 0.761 |
GSK3A |
0.731 | -0.034 | 4 | 0.419 |
STK33 |
0.731 | -0.092 | 2 | 0.558 |
DAPK1 |
0.729 | -0.025 | -3 | 0.746 |
VRK1 |
0.729 | -0.114 | 2 | 0.828 |
CK1G1 |
0.729 | -0.084 | -3 | 0.429 |
DMPK1 |
0.729 | 0.050 | -3 | 0.777 |
CK1E |
0.728 | -0.113 | -3 | 0.425 |
MYO3A |
0.728 | 0.084 | 1 | 0.792 |
MPSK1 |
0.728 | -0.123 | 1 | 0.640 |
DYRK4 |
0.728 | -0.050 | 1 | 0.475 |
CRIK |
0.728 | 0.034 | -3 | 0.689 |
BUB1 |
0.728 | -0.017 | -5 | 0.706 |
JNK1 |
0.726 | -0.035 | 1 | 0.474 |
PBK |
0.725 | -0.045 | 1 | 0.600 |
OSR1 |
0.725 | -0.001 | 2 | 0.763 |
MYO3B |
0.723 | 0.021 | 2 | 0.803 |
GRK3 |
0.723 | -0.088 | -2 | 0.552 |
ASK1 |
0.721 | -0.004 | 1 | 0.834 |
CK2A1 |
0.719 | -0.017 | 1 | 0.529 |
MOK |
0.718 | -0.031 | 1 | 0.530 |
TTK |
0.718 | -0.024 | -2 | 0.702 |
CK1A2 |
0.717 | -0.111 | -3 | 0.381 |
ALPHAK3 |
0.716 | -0.009 | -1 | 0.625 |
HASPIN |
0.715 | -0.043 | -1 | 0.550 |
CK1D |
0.715 | -0.120 | -3 | 0.372 |
MAK |
0.715 | -0.028 | -2 | 0.635 |
PDHK3_TYR |
0.711 | 0.048 | 4 | 0.810 |
STLK3 |
0.708 | -0.061 | 1 | 0.813 |
PINK1_TYR |
0.705 | -0.017 | 1 | 0.776 |
TESK1_TYR |
0.705 | -0.053 | 3 | 0.774 |
TYK2 |
0.705 | 0.051 | 1 | 0.823 |
BIKE |
0.702 | -0.090 | 1 | 0.547 |
RET |
0.702 | -0.000 | 1 | 0.817 |
LIMK2_TYR |
0.701 | -0.022 | -3 | 0.792 |
YANK3 |
0.700 | -0.087 | 2 | 0.336 |
NEK10_TYR |
0.700 | 0.063 | 1 | 0.766 |
MAP2K7_TYR |
0.700 | -0.145 | 2 | 0.773 |
TNNI3K_TYR |
0.699 | 0.058 | 1 | 0.763 |
DDR1 |
0.698 | -0.015 | 4 | 0.750 |
ROS1 |
0.698 | -0.020 | 3 | 0.632 |
BMPR2_TYR |
0.698 | -0.059 | -1 | 0.701 |
FLT3 |
0.698 | 0.039 | 3 | 0.648 |
PDHK4_TYR |
0.697 | -0.072 | 2 | 0.771 |
PKMYT1_TYR |
0.697 | -0.156 | 3 | 0.719 |
JAK2 |
0.697 | -0.007 | 1 | 0.829 |
EPHA6 |
0.696 | -0.040 | -1 | 0.690 |
MAP2K6_TYR |
0.696 | -0.111 | -1 | 0.724 |
MAP2K4_TYR |
0.696 | -0.176 | -1 | 0.706 |
JAK3 |
0.695 | -0.017 | 1 | 0.816 |
LIMK1_TYR |
0.694 | -0.130 | 2 | 0.805 |
JAK1 |
0.693 | 0.033 | 1 | 0.837 |
CSF1R |
0.693 | -0.036 | 3 | 0.626 |
MST1R |
0.693 | -0.098 | 3 | 0.657 |
PDGFRB |
0.692 | -0.035 | 3 | 0.651 |
TYRO3 |
0.691 | -0.101 | 3 | 0.662 |
PDHK1_TYR |
0.691 | -0.150 | -1 | 0.713 |
INSRR |
0.690 | -0.032 | 3 | 0.606 |
TNK1 |
0.687 | -0.051 | 3 | 0.643 |
EPHB4 |
0.687 | -0.109 | -1 | 0.674 |
PDGFRA |
0.687 | -0.061 | 3 | 0.649 |
FGFR1 |
0.686 | -0.054 | 3 | 0.615 |
FGFR2 |
0.684 | -0.084 | 3 | 0.648 |
KDR |
0.684 | -0.065 | 3 | 0.598 |
ABL2 |
0.683 | -0.101 | -1 | 0.601 |
AAK1 |
0.682 | -0.078 | 1 | 0.431 |
KIT |
0.681 | -0.101 | 3 | 0.628 |
FLT4 |
0.679 | -0.065 | 3 | 0.594 |
ALK |
0.679 | -0.087 | 3 | 0.557 |
INSR |
0.678 | -0.061 | 3 | 0.584 |
CK1A |
0.678 | -0.141 | -3 | 0.293 |
EPHB1 |
0.678 | -0.129 | 1 | 0.778 |
NTRK2 |
0.677 | -0.082 | 3 | 0.595 |
NTRK1 |
0.677 | -0.097 | -1 | 0.660 |
FER |
0.677 | -0.164 | 1 | 0.746 |
TEK |
0.676 | -0.152 | 3 | 0.588 |
ABL1 |
0.676 | -0.135 | -1 | 0.585 |
DDR2 |
0.676 | -0.034 | 3 | 0.570 |
AXL |
0.676 | -0.138 | 3 | 0.617 |
WEE1_TYR |
0.675 | -0.098 | -1 | 0.560 |
EPHA4 |
0.675 | -0.114 | 2 | 0.650 |
EPHB2 |
0.675 | -0.116 | -1 | 0.652 |
YES1 |
0.674 | -0.155 | -1 | 0.594 |
EPHB3 |
0.674 | -0.140 | -1 | 0.657 |
CK1G3 |
0.674 | -0.089 | -3 | 0.250 |
ITK |
0.674 | -0.147 | -1 | 0.564 |
PTK6 |
0.674 | -0.126 | -1 | 0.515 |
LTK |
0.673 | -0.115 | 3 | 0.577 |
FGFR3 |
0.673 | -0.087 | 3 | 0.622 |
FLT1 |
0.673 | -0.094 | -1 | 0.686 |
FGR |
0.673 | -0.206 | 1 | 0.716 |
ERBB2 |
0.672 | -0.123 | 1 | 0.783 |
BTK |
0.671 | -0.176 | -1 | 0.510 |
HCK |
0.671 | -0.193 | -1 | 0.575 |
YANK2 |
0.670 | -0.100 | 2 | 0.352 |
MERTK |
0.670 | -0.149 | 3 | 0.620 |
LCK |
0.670 | -0.141 | -1 | 0.581 |
TXK |
0.669 | -0.138 | 1 | 0.688 |
TNK2 |
0.669 | -0.197 | 3 | 0.573 |
SRMS |
0.669 | -0.186 | 1 | 0.752 |
TEC |
0.669 | -0.151 | -1 | 0.489 |
EGFR |
0.668 | -0.051 | 1 | 0.706 |
FRK |
0.668 | -0.125 | -1 | 0.599 |
MET |
0.667 | -0.164 | 3 | 0.618 |
NTRK3 |
0.667 | -0.116 | -1 | 0.623 |
MUSK |
0.665 | -0.093 | 1 | 0.678 |
EPHA7 |
0.665 | -0.147 | 2 | 0.678 |
EPHA3 |
0.665 | -0.157 | 2 | 0.638 |
BMX |
0.665 | -0.154 | -1 | 0.484 |
FGFR4 |
0.662 | -0.076 | -1 | 0.602 |
EPHA1 |
0.662 | -0.192 | 3 | 0.590 |
CSK |
0.662 | -0.117 | 2 | 0.682 |
BLK |
0.662 | -0.161 | -1 | 0.590 |
IGF1R |
0.661 | -0.082 | 3 | 0.532 |
EPHA5 |
0.660 | -0.122 | 2 | 0.641 |
MATK |
0.659 | -0.146 | -1 | 0.561 |
LYN |
0.655 | -0.190 | 3 | 0.557 |
EPHA8 |
0.655 | -0.152 | -1 | 0.619 |
FYN |
0.654 | -0.153 | -1 | 0.548 |
PTK2B |
0.652 | -0.175 | -1 | 0.547 |
SYK |
0.650 | -0.100 | -1 | 0.614 |
PTK2 |
0.649 | -0.099 | -1 | 0.631 |
SRC |
0.645 | -0.196 | -1 | 0.541 |
EPHA2 |
0.643 | -0.164 | -1 | 0.598 |
ERBB4 |
0.643 | -0.117 | 1 | 0.671 |
CK1G2 |
0.642 | -0.142 | -3 | 0.345 |
FES |
0.627 | -0.204 | -1 | 0.467 |
ZAP70 |
0.626 | -0.125 | -1 | 0.549 |