Motif 820 (n=152)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| B5ME19 | EIF3CL | S866 | ochoa | Eukaryotic translation initiation factor 3 subunit C-like protein | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. {ECO:0000250|UniProtKB:Q99613}. |
| H3BQ06 | None | S28 | ochoa | TBC1 domain family member 24 | May act as a GTPase-activating protein for Rab family protein(s). Involved in neuronal projections development, probably through a negative modulation of ARF6 function. Involved in the regulation of synaptic vesicle trafficking. {ECO:0000256|ARBA:ARBA00046245}. |
| O00287 | RFXAP | S237 | ochoa | Regulatory factor X-associated protein (RFX-associated protein) (RFX DNA-binding complex 36 kDa subunit) | Part of the RFX complex that binds to the X-box of MHC II promoters. |
| O00459 | PIK3R2 | S438 | ochoa | Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta) | Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy (PubMed:23604317). Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity). {ECO:0000250|UniProtKB:O08908, ECO:0000269|PubMed:23604317}. |
| O14924 | RGS12 | S876 | ochoa | Regulator of G-protein signaling 12 (RGS12) | Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. {ECO:0000250|UniProtKB:O08774}.; FUNCTION: [Isoform 5]: Behaves as a cell cycle-dependent transcriptional repressor, promoting inhibition of S-phase DNA synthesis. {ECO:0000269|PubMed:12024043}. |
| O43314 | PPIP5K2 | S788 | ochoa | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 2) (Histidine acid phosphatase domain-containing protein 1) (InsP6 and PP-IP5 kinase 2) (VIP1 homolog 2) (hsVIP2) | Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4 (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Required for normal hearing (PubMed:29590114). {ECO:0000269|PubMed:17690096, ECO:0000269|PubMed:17702752, ECO:0000269|PubMed:21222653, ECO:0000269|PubMed:29590114}. |
| O43768 | ENSA | S43 | ochoa | Alpha-endosulfine (ARPP-19e) | Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents. {ECO:0000250, ECO:0000269|PubMed:9653196}. |
| O75379 | VAMP4 | S90 | ochoa | Vesicle-associated membrane protein 4 (VAMP-4) | Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule. |
| O75387 | SLC43A1 | S267 | ochoa | Large neutral amino acids transporter small subunit 3 (L-type amino acid transporter 3) (Prostate cancer overexpressed gene 1 protein) (Solute carrier family 43 member 1) | Uniport that mediates the transport of neutral amino acids such as L-leucine, L-isoleucine, L-valine, and L-phenylalanine (PubMed:12930836). The transport activity is sodium ions-independent, electroneutral and mediated by a facilitated diffusion (PubMed:12930836). {ECO:0000269|PubMed:12930836}. |
| O75943 | RAD17 | S410 | ochoa | Cell cycle checkpoint protein RAD17 (hRad17) (RF-C/activator 1 homolog) | Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage (PubMed:10208430, PubMed:11418864, PubMed:11687627, PubMed:11799063, PubMed:12672690, PubMed:14624239, PubMed:15235112). Has a weak ATPase activity required for binding to chromatin (PubMed:10208430, PubMed:11418864, PubMed:11687627, PubMed:11799063, PubMed:12672690, PubMed:14624239, PubMed:15235112). Participates in the recruitment of the 9-1-1 (RAD1-RAD9-HUS1) complex and RHNO1 onto chromatin, and in CHEK1 activation (PubMed:21659603). Involved in homologous recombination by mediating recruitment of the MRN complex to DNA damage sites (PubMed:24534091). May also serve as a sensor of DNA replication progression (PubMed:12578958, PubMed:14500819, PubMed:15538388). {ECO:0000269|PubMed:10208430, ECO:0000269|PubMed:11418864, ECO:0000269|PubMed:11687627, ECO:0000269|PubMed:11799063, ECO:0000269|PubMed:12578958, ECO:0000269|PubMed:12672690, ECO:0000269|PubMed:14500819, ECO:0000269|PubMed:14624239, ECO:0000269|PubMed:15235112, ECO:0000269|PubMed:15538388, ECO:0000269|PubMed:21659603, ECO:0000269|PubMed:24534091}. |
| O76083 | PDE9A | S569 | ochoa | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35) | Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP (PubMed:18757755, PubMed:21483814, PubMed:9624146). Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart (PubMed:25799991). Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein (Probable). In brain, involved in cognitive function, such as learning and long-term memory (By similarity). {ECO:0000250|UniProtKB:Q8QZV1, ECO:0000269|PubMed:18757755, ECO:0000269|PubMed:21483814, ECO:0000269|PubMed:25799991, ECO:0000269|PubMed:9624146, ECO:0000305}. |
| O94915 | FRYL | S212 | ochoa | Protein furry homolog-like (ALL1-fused gene from chromosome 4p12 protein) | Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching (By similarity). May function as a transcriptional activator. {ECO:0000250, ECO:0000269|PubMed:16061630}. |
| O95425 | SVIL | S1400 | ochoa | Supervillin (Archvillin) (p205/p250) | [Isoform 1]: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699). Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (PubMed:19109420). {ECO:0000269|PubMed:12711699, ECO:0000269|PubMed:19109420}.; FUNCTION: [Isoform 2]: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity). {ECO:0000250|UniProtKB:O46385}. |
| P07814 | EPRS1 | S910 | ochoa | Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)] | Multifunctional protein which primarily functions within the aminoacyl-tRNA synthetase multienzyme complex, also known as multisynthetase complex. Within the complex it catalyzes the attachment of both L-glutamate and L-proline to their cognate tRNAs in a two-step reaction where the amino acid is first activated by ATP to form a covalent intermediate with AMP. Subsequently, the activated amino acid is transferred to the acceptor end of the cognate tRNA to form L-glutamyl-tRNA(Glu) and L-prolyl-tRNA(Pro) (PubMed:23263184, PubMed:24100331, PubMed:29576217, PubMed:3290852, PubMed:37212275). Upon interferon-gamma stimulation, EPRS1 undergoes phosphorylation, causing its dissociation from the aminoacyl-tRNA synthetase multienzyme complex. It is recruited to form the GAIT complex, which binds to stem loop-containing GAIT elements found in the 3'-UTR of various inflammatory mRNAs, such as ceruloplasmin. The GAIT complex inhibits the translation of these mRNAs, allowing interferon-gamma to redirect the function of EPRS1 from protein synthesis to translation inhibition in specific cell contexts (PubMed:15479637, PubMed:23071094). Furthermore, it can function as a downstream effector in the mTORC1 signaling pathway, by promoting the translocation of SLC27A1 from the cytoplasm to the plasma membrane where it mediates the uptake of long-chain fatty acid by adipocytes. Thereby, EPRS1 also plays a role in fat metabolism and more indirectly influences lifespan (PubMed:28178239). {ECO:0000269|PubMed:15479637, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:28178239, ECO:0000269|PubMed:29576217, ECO:0000269|PubMed:3290852, ECO:0000269|PubMed:37212275}. |
| P08962 | CD63 | S113 | ochoa | CD63 antigen (Granulophysin) (Lysosomal-associated membrane protein 3) (LAMP-3) (Lysosome integral membrane protein 1) (Limp1) (Melanoma-associated antigen ME491) (OMA81H) (Ocular melanoma-associated antigen) (Tetraspanin-30) (Tspan-30) (CD antigen CD63) | Functions as a cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli. {ECO:0000269|PubMed:16917503, ECO:0000269|PubMed:21803846, ECO:0000269|PubMed:21962903, ECO:0000269|PubMed:23632027, ECO:0000269|PubMed:24635319}. |
| P10606 | COX5B | S71 | ochoa|psp | Cytochrome c oxidase subunit 5B, mitochondrial (Cytochrome c oxidase polypeptide Vb) | Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P04037}. |
| P13807 | GYS1 | S288 | ochoa | Glycogen [starch] synthase, muscle (EC 2.4.1.11) (Glycogen synthase 1) | Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. {ECO:0000269|PubMed:35835870}. |
| P15822 | HIVEP1 | S637 | ochoa | Zinc finger protein 40 (Cirhin interaction protein) (CIRIP) (Gate keeper of apoptosis-activating protein) (GAAP) (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis. |
| P16070 | CD44 | S718 | ochoa | CD44 antigen (CDw44) (Epican) (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Heparan sulfate proteoglycan) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44) | Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment (PubMed:16541107, PubMed:19703720, PubMed:22726066). Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection (PubMed:7528188). Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases (PubMed:18757307, PubMed:23589287). Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion (PubMed:15123640). {ECO:0000269|PubMed:15123640, ECO:0000269|PubMed:16541107, ECO:0000269|PubMed:18757307, ECO:0000269|PubMed:19703720, ECO:0000269|PubMed:22726066, ECO:0000269|PubMed:23589287, ECO:0000269|PubMed:7528188}. |
| P16152 | CBR1 | S160 | ochoa | Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (15-hydroxyprostaglandin dehydrogenase [NADP(+)]) (EC 1.1.1.196, EC 1.1.1.197) (20-beta-hydroxysteroid dehydrogenase) (Alcohol dehydrogenase [NAD(P)+] CBR1) (EC 1.1.1.71) (NADPH-dependent carbonyl reductase 1) (Prostaglandin 9-ketoreductase) (PG-9-KR) (Prostaglandin-E(2) 9-reductase) (EC 1.1.1.189) (Short chain dehydrogenase/reductase family 21C member 1) | NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol (PubMed:15799708, PubMed:17344335, PubMed:17912391, PubMed:18449627, PubMed:18826943, PubMed:1921984, PubMed:7005231). Can convert prostaglandin E to prostaglandin F2-alpha (By similarity). Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione (PubMed:17344335, PubMed:18826943). In addition, participates in the glucocorticoid metabolism by catalyzing the NADPH-dependent cortisol/corticosterone into 20beta-dihydrocortisol (20b-DHF) or 20beta-corticosterone (20b-DHB), which are weak agonists of NR3C1 and NR3C2 in adipose tissue (PubMed:28878267). {ECO:0000250|UniProtKB:Q28960, ECO:0000269|PubMed:15799708, ECO:0000269|PubMed:17344335, ECO:0000269|PubMed:17912391, ECO:0000269|PubMed:18449627, ECO:0000269|PubMed:18826943, ECO:0000269|PubMed:1921984, ECO:0000269|PubMed:28878267, ECO:0000269|PubMed:7005231}. |
| P17302 | GJA1 | S306 | ochoa | Gap junction alpha-1 protein (Connexin-43) (Cx43) (Gap junction 43 kDa heart protein) | Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles (By similarity). {ECO:0000250|UniProtKB:P08050, ECO:0000250|UniProtKB:P23242}. |
| P17480 | UBTF | S638 | ochoa | Nucleolar transcription factor 1 (Autoantigen NOR-90) (Upstream-binding factor 1) (UBF-1) | Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I (Pol I) through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element and can activate Pol I promoter escape. {ECO:0000269|PubMed:11250903, ECO:0000269|PubMed:11283244, ECO:0000269|PubMed:16858408, ECO:0000269|PubMed:28777933, ECO:0000269|PubMed:7982918}. |
| P17568 | NDUFB7 | S73 | ochoa | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 (Cell adhesion protein SQM1) (Complex I-B18) (CI-B18) (NADH-ubiquinone oxidoreductase B18 subunit) | Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371, ECO:0000269|PubMed:33502047}. |
| P18084 | ITGB5 | S779 | ochoa | Integrin beta-5 | Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for adenovirus type C. {ECO:0000269|PubMed:20615244}. |
| P24588 | AKAP5 | S53 | ochoa | A-kinase anchor protein 5 (AKAP-5) (A-kinase anchor protein 79 kDa) (AKAP 79) (H21) (cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein) | Multivalent scaffold protein that anchors the cAMP-dependent protein kinase/PKA to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors (PubMed:1512224). Association with the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade. Plays a role in long term synaptic potentiation by regulating protein trafficking from the dendritic recycling endosomes to the plasma membrane and controlling both structural and functional plasticity at excitatory synapses (PubMed:25589740). In hippocampal pyramidal neurons, recruits KCNK2/TREK-1 channel at postsynaptic dense bodies microdomains and converts it to a leak channel no longer sensitive to stimulation by arachidonic acid, acidic pH or mechanical stress, nor inhibited by Gq-coupled receptors but still under the negative control of Gs-coupled receptors (By similarity). Associates with ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where it recruits NFATC2/NFAT1 and couples store-operated Ca(2+) influx to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses (PubMed:33941685). {ECO:0000250|UniProtKB:D3YVF0, ECO:0000269|PubMed:1512224, ECO:0000269|PubMed:25589740, ECO:0000269|PubMed:33941685}. |
| P25100 | ADRA1D | S516 | psp | Alpha-1D adrenergic receptor (Alpha-1A adrenergic receptor) (Alpha-1D adrenoreceptor) (Alpha-1D adrenoceptor) (Alpha-adrenergic receptor 1a) | This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium. |
| P27105 | STOM | S161 | ochoa | Stomatin (Erythrocyte band 7 integral membrane protein) (Erythrocyte membrane protein band 7.2) (Protein 7.2b) | Regulates ion channel activity and transmembrane ion transport. Regulates ASIC2 and ASIC3 channel activity. |
| P33241 | LSP1 | S282 | ochoa | Lymphocyte-specific protein 1 (47 kDa actin-binding protein) (52 kDa phosphoprotein) (pp52) (Lymphocyte-specific antigen WP34) | May play a role in mediating neutrophil activation and chemotaxis. {ECO:0000250}. |
| P35222 | CTNNB1 | S184 | psp | Catenin beta-1 (Beta-catenin) | Key downstream component of the canonical Wnt signaling pathway (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). Also acts as a coactivator for other transcription factors, such as NR5A2 (PubMed:22187462). Promotes epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via driving transcription of CTNNB1/TCF-target genes (PubMed:29910125). Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (By similarity). Acts as a negative regulator of centrosome cohesion (PubMed:18086858). Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization (PubMed:21262353). Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (PubMed:18957423). Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity). Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, via promoting the transcription of differentiation factors such as LEF1, BMP2 and BMP4 (By similarity). Activity is repressed in a MSX1-mediated manner at the bell stage of mesenchymal tooth germ formation which prevents premature differentiation of odontoblasts (By similarity). {ECO:0000250|UniProtKB:Q02248, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:18077326, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18957423, ECO:0000269|PubMed:21262353, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22187462, ECO:0000269|PubMed:22647378, ECO:0000269|PubMed:22699938, ECO:0000269|PubMed:29910125}. |
| P35348 | ADRA1A | S352 | psp | Alpha-1A adrenergic receptor (Alpha-1A adrenoreceptor) (Alpha-1A adrenoceptor) (Alpha-1C adrenergic receptor) (Alpha-adrenergic receptor 1c) | This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. {ECO:0000269|PubMed:18802028, ECO:0000269|PubMed:22120526}. |
| P35610 | SOAT1 | S86 | ochoa | Sterol O-acyltransferase 1 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 1) (ACAT-1) (Cholesterol acyltransferase 1) | Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol (PubMed:16154994, PubMed:16647063, PubMed:32433613, PubMed:32433614, PubMed:32944968, PubMed:9020103). Plays a role in lipoprotein assembly and dietary cholesterol absorption (PubMed:16154994, PubMed:9020103). Preferentially utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) as a substrate: shows a higher activity towards an acyl-CoA substrate with a double bond at the delta-9 position (9Z) than towards saturated acyl-CoA or an unsaturated acyl-CoA with a double bond at the delta-7 (7Z) or delta-11 (11Z) positions (PubMed:11294643, PubMed:32433614). {ECO:0000269|PubMed:11294643, ECO:0000269|PubMed:16154994, ECO:0000269|PubMed:16647063, ECO:0000269|PubMed:32433613, ECO:0000269|PubMed:32433614, ECO:0000269|PubMed:32944968, ECO:0000269|PubMed:9020103}. |
| P35613 | BSG | S246 | psp | Basigin (5F7) (Collagenase stimulatory factor) (Extracellular matrix metalloproteinase inducer) (EMMPRIN) (Hepatoma-associated antigen) (HAb18G) (Leukocyte activation antigen M6) (OK blood group antigen) (Tumor cell-derived collagenase stimulatory factor) (TCSF) (CD antigen CD147) | [Isoform 1]: Essential for normal retinal maturation and development (By similarity). Acts as a retinal cell surface receptor for NXNL1 and plays an important role in NXNL1-mediated survival of retinal cone photoreceptors (PubMed:25957687). In association with glucose transporter SLC16A1/GLUT1 and NXNL1, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors (PubMed:25957687). May act as a potent stimulator of IL6 secretion in multiple cell lines that include monocytes (PubMed:21620857). {ECO:0000250|UniProtKB:P18572, ECO:0000269|PubMed:21620857, ECO:0000269|PubMed:25957687}.; FUNCTION: [Isoform 1]: (Microbial infection) Erythrocyte receptor for P.falciparum RH5 which is essential for erythrocyte invasion by the merozoite stage of P.falciparum isolates 3D7 and Dd2. {ECO:0000269|PubMed:22080952}.; FUNCTION: [Isoform 2]: Signaling receptor for cyclophilins, essential for PPIA/CYPA and PPIB/CYPB-dependent signaling related to chemotaxis and adhesion of immune cells (PubMed:11688976, PubMed:11943775). Plays an important role in targeting monocarboxylate transporters SLC16A1/GLUT1, SLC16A11 and SLC16A12 to the plasma membrane (PubMed:17127621, PubMed:21778275, PubMed:28666119). Acts as a coreceptor for vascular endothelial growth factor receptor 2 (KDR/VEGFR2) in endothelial cells enhancing its VEGFA-mediated activation and downstream signaling (PubMed:25825981). Promotes angiogenesis through EPAS1/HIF2A-mediated up-regulation of VEGFA (isoform VEGF-165 and VEGF-121) and KDR/VEGFR2 in endothelial cells (PubMed:19837976). Plays a key role in regulating tumor growth, invasion, metastasis and neoangiogenesis by stimulating the production and release of extracellular matrix metalloproteinases and KDR/VEGFR2 by both tumor cells and stromal cells (fibroblasts and endothelial cells) (PubMed:11992541, PubMed:12553375, PubMed:15833850). {ECO:0000269|PubMed:11688976, ECO:0000269|PubMed:11943775, ECO:0000269|PubMed:11992541, ECO:0000269|PubMed:12553375, ECO:0000269|PubMed:15833850, ECO:0000269|PubMed:17127621, ECO:0000269|PubMed:19837976, ECO:0000269|PubMed:21778275, ECO:0000269|PubMed:25825981, ECO:0000269|PubMed:28666119}.; FUNCTION: [Isoform 2]: (Microbial infection) Erythrocyte receptor for P.falciparum RH5 which is essential for erythrocyte invasion by the merozoite stage of P.falciparum isolates 3D7, Dd2, 7G8 and HB3 (PubMed:22080952, PubMed:26195724). Binding of P.falciparum RH5 results in BSG dimerization which triggers an increase in intracellular Ca(2+) in the erythrocyte (PubMed:28409866). This essential step leads to a rearrangement of the erythrocyte cytoskeleton required for the merozoite invasion (PubMed:28409866). {ECO:0000269|PubMed:22080952, ECO:0000269|PubMed:26195724, ECO:0000269|PubMed:28409866}.; FUNCTION: [Isoform 2]: (Microbial infection) Can facilitate human SARS coronavirus (SARS-CoV-1) infection via its interaction with virus-associated PPIA/CYPA. {ECO:0000269|PubMed:15688292}.; FUNCTION: [Isoform 2]: (Microbial infection) Can facilitate HIV-1 infection via its interaction with virus-associated PPIA/CYPA. {ECO:0000269|PubMed:11353871}.; FUNCTION: [Isoform 2]: (Microbial infection) First described as a receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), it is not required for SARS-CoV-2 infection. {ECO:0000269|PubMed:33432067, ECO:0000303|PubMed:32307653}.; FUNCTION: [Isoform 2]: (Microbial infection) Acts as a receptor for measles virus. {ECO:0000269|PubMed:20147391}.; FUNCTION: [Isoform 2]: (Microbial infection) Promotes entry of pentamer-expressing human cytomegalovirus (HCMV) into epithelial and endothelial cells. {ECO:0000269|PubMed:29739904}. |
| P41214 | EIF2D | S404 | ochoa | Eukaryotic translation initiation factor 2D (eIF2d) (Hepatocellular carcinoma-associated antigen 56) (Ligatin) | Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. {ECO:0000269|PubMed:20566627, ECO:0000269|PubMed:20713520}. |
| P41240 | CSK | S364 | psp | Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-Src kinase) (Protein-tyrosine kinase CYL) | Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK. {ECO:0000269|PubMed:1639064, ECO:0000269|PubMed:9281320}. |
| P45973 | CBX5 | S45 | ochoa | Chromobox protein homolog 5 (Antigen p25) (Heterochromatin protein 1 homolog alpha) (HP1 alpha) | Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph) (PubMed:19783980). May contribute to the association of heterochromatin with the inner nuclear membrane by interactions with the lamin-B receptor (LBR) (PubMed:19783980). Involved in the formation of kinetochore through interaction with the MIS12 complex subunit NSL1 (PubMed:19783980, PubMed:20231385). Required for the formation of the inner centromere (PubMed:20231385). {ECO:0000269|PubMed:19783980, ECO:0000269|PubMed:20231385}. |
| P46939 | UTRN | S2615 | ochoa | Utrophin (Dystrophin-related protein 1) (DRP-1) | May play a role in anchoring the cytoskeleton to the plasma membrane. {ECO:0000250}. |
| P53004 | BLVRA | S237 | ochoa|psp | Biliverdin reductase A (BVR A) (EC 1.3.1.24) (Biliverdin-IX alpha-reductase) | Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IXalpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor (PubMed:10858451, PubMed:7929092, PubMed:8424666, PubMed:8631357). Does not reduce bilirubin IXbeta (PubMed:10858451). Uses the reactants NADH or NADPH depending on the pH; NADH is used at the acidic pH range (6-6.9) and NADPH at the alkaline range (8.5-8.7) (PubMed:7929092, PubMed:8424666, PubMed:8631357). NADPH, however, is the probable reactant in biological systems (PubMed:7929092). {ECO:0000269|PubMed:10858451, ECO:0000269|PubMed:7929092, ECO:0000269|PubMed:8424666, ECO:0000269|PubMed:8631357}. |
| P54132 | BLM | S517 | ochoa | RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) | ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}. |
| P86790 | CCZ1B | S368 | ochoa | Vacuolar fusion protein CCZ1 homolog B (Vacuolar fusion protein CCZ1 homolog-like) | None |
| P86791 | CCZ1 | S368 | ochoa | Vacuolar fusion protein CCZ1 homolog | Acts in concert with MON1A, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form (PubMed:23084991). {ECO:0000269|PubMed:23084991}. |
| Q05209 | PTPN12 | S83 | ochoa | Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1) | Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172). {ECO:0000269|PubMed:17329398, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:27134172}. |
| Q05655 | PRKCD | S626 | ochoa | Protein kinase C delta type (EC 2.7.11.13) (Tyrosine-protein kinase PRKCD) (EC 2.7.10.2) (nPKC-delta) [Cleaved into: Protein kinase C delta type regulatory subunit; Protein kinase C delta type catalytic subunit (Sphingosine-dependent protein kinase-1) (SDK1)] | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression as well as survival of several cancers, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses (PubMed:21406692, PubMed:21810427). Negatively regulates B cell proliferation and also has an important function in self-antigen induced B cell tolerance induction (By similarity). Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene transcription and apoptosis (PubMed:21406692, PubMed:21810427). In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus, causing the phosphorylation of p53/TP53 (PubMed:21406692, PubMed:21810427). In the case of ER stress or DNA damage-induced apoptosis, can form a complex with the tyrosine-protein kinase ABL1 which trigger apoptosis independently of p53/TP53 (PubMed:21406692, PubMed:21810427). In cytosol can trigger apoptosis by activating MAPK11 or MAPK14, inhibiting AKT1 and decreasing the level of X-linked inhibitor of apoptosis protein (XIAP), whereas in nucleus induces apoptosis via the activation of MAPK8 or MAPK9. Upon ionizing radiation treatment, is required for the activation of the apoptosis regulators BAX and BAK, which trigger the mitochondrial cell death pathway. Can phosphorylate MCL1 and target it for degradation which is sufficient to trigger for BAX activation and apoptosis. Is required for the control of cell cycle progression both at G1/S and G2/M phases. Mediates phorbol 12-myristate 13-acetate (PMA)-induced inhibition of cell cycle progression at G1/S phase by up-regulating the CDK inhibitor CDKN1A/p21 and inhibiting the cyclin CCNA2 promoter activity. In response to UV irradiation can phosphorylate CDK1, which is important for the G2/M DNA damage checkpoint activation (By similarity). Can protect glioma cells from the apoptosis induced by TNFSF10/TRAIL, probably by inducing increased phosphorylation and subsequent activation of AKT1 (PubMed:15774464). Is highly expressed in a number of cancer cells and promotes cell survival and resistance against chemotherapeutic drugs by inducing cyclin D1 (CCND1) and hyperphosphorylation of RB1, and via several pro-survival pathways, including NF-kappa-B, AKT1 and MAPK1/3 (ERK1/2). Involved in antifungal immunity by mediating phosphorylation and activation of CARD9 downstream of C-type lectin receptors activation, promoting interaction between CARD9 and BCL10, followed by activation of NF-kappa-B and MAP kinase p38 pathways (By similarity). Can also act as tumor suppressor upon mitogenic stimulation with PMA or TPA. In N-formyl-methionyl-leucyl-phenylalanine (fMLP)-treated cells, is required for NCF1 (p47-phox) phosphorylation and activation of NADPH oxidase activity, and regulates TNF-elicited superoxide anion production in neutrophils, by direct phosphorylation and activation of NCF1 or indirectly through MAPK1/3 (ERK1/2) signaling pathways (PubMed:19801500). May also play a role in the regulation of NADPH oxidase activity in eosinophil after stimulation with IL5, leukotriene B4 or PMA (PubMed:11748588). In collagen-induced platelet aggregation, acts a negative regulator of filopodia formation and actin polymerization by interacting with and negatively regulating VASP phosphorylation (PubMed:16940418). Downstream of PAR1, PAR4 and CD36/GP4 receptors, regulates differentially platelet dense granule secretion; acts as a positive regulator in PAR-mediated granule secretion, whereas it negatively regulates CD36/GP4-mediated granule release (PubMed:19587372). Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin (PubMed:11877440). The catalytic subunit phosphorylates 14-3-3 proteins (YWHAB, YWHAZ and YWHAH) in a sphingosine-dependent fashion (By similarity). Phosphorylates ELAVL1 in response to angiotensin-2 treatment (PubMed:18285462). Phosphorylates mitochondrial phospholipid scramblase 3 (PLSCR3), resulting in increased cardiolipin expression on the mitochondrial outer membrane which facilitates apoptosis (PubMed:12649167). Phosphorylates SMPD1 which induces SMPD1 secretion (PubMed:17303575). {ECO:0000250|UniProtKB:P28867, ECO:0000269|PubMed:11748588, ECO:0000269|PubMed:11877440, ECO:0000269|PubMed:12649167, ECO:0000269|PubMed:15774464, ECO:0000269|PubMed:16940418, ECO:0000269|PubMed:17303575, ECO:0000269|PubMed:18285462, ECO:0000269|PubMed:19587372, ECO:0000269|PubMed:19801500, ECO:0000303|PubMed:21406692, ECO:0000303|PubMed:21810427}. |
| Q12830 | BPTF | S2098 | ochoa | Nucleosome-remodeling factor subunit BPTF (Bromodomain and PHD finger-containing transcription factor) (Fetal Alz-50 clone 1 protein) (Fetal Alzheimer antigen) | Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:28801535). The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes (PubMed:16728976, PubMed:16728978). Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent (PubMed:16728976, PubMed:16728978, PubMed:18042461). May also regulate transcription through direct binding to DNA or transcription factors (PubMed:10575013). {ECO:0000269|PubMed:10575013, ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:16728976, ECO:0000269|PubMed:16728978, ECO:0000269|PubMed:18042461, ECO:0000269|PubMed:28801535}. |
| Q13148 | TARDBP | S254 | psp | TAR DNA-binding protein 43 (TDP-43) | RNA-binding protein that is involved in various steps of RNA biogenesis and processing (PubMed:23519609). Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs (PubMed:23519609, PubMed:24240615, PubMed:24464995). In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases (PubMed:21358640, PubMed:29438978). Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts (PubMed:28794432). Also regulates mRNA stability by recruiting CNOT7/CAF1 deadenylase on mRNA 3'UTR leading to poly(A) tail deadenylation and thus shortening (PubMed:30520513). In response to oxidative insult, associates with stalled ribosomes localized to stress granules (SGs) and contributes to cell survival (PubMed:19765185, PubMed:23398327). Also participates in the normal skeletal muscle formation and regeneration, forming cytoplasmic myo-granules and binding mRNAs that encode sarcomeric proteins (PubMed:30464263). Plays a role in the maintenance of the circadian clock periodicity via stabilization of the CRY1 and CRY2 proteins in a FBXL3-dependent manner (PubMed:27123980). Negatively regulates the expression of CDK6 (PubMed:19760257). Regulates the expression of HDAC6, ATG7 and VCP in a PPIA/CYPA-dependent manner (PubMed:25678563). {ECO:0000269|PubMed:11285240, ECO:0000269|PubMed:17481916, ECO:0000269|PubMed:19760257, ECO:0000269|PubMed:19765185, ECO:0000269|PubMed:21358640, ECO:0000269|PubMed:23398327, ECO:0000269|PubMed:23519609, ECO:0000269|PubMed:24240615, ECO:0000269|PubMed:24464995, ECO:0000269|PubMed:25678563, ECO:0000269|PubMed:27123980, ECO:0000269|PubMed:28794432, ECO:0000269|PubMed:29438978, ECO:0000269|PubMed:30464263, ECO:0000269|PubMed:30520513}. |
| Q13308 | PTK7 | S784 | ochoa | Inactive tyrosine-protein kinase 7 (Colon carcinoma kinase 4) (CCK-4) (Protein-tyrosine kinase 7) (Pseudo tyrosine kinase receptor 7) (Tyrosine-protein kinase-like 7) | Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis. {ECO:0000269|PubMed:18471990, ECO:0000269|PubMed:20558616, ECO:0000269|PubMed:20837484, ECO:0000269|PubMed:21103379, ECO:0000269|PubMed:21132015}. |
| Q13427 | PPIG | S696 | ochoa | Peptidyl-prolyl cis-trans isomerase G (PPIase G) (Peptidyl-prolyl isomerase G) (EC 5.2.1.8) (CASP10) (Clk-associating RS-cyclophilin) (CARS-Cyp) (CARS-cyclophilin) (SR-cyclophilin) (SR-cyp) (SRcyp) (Cyclophilin G) (Rotamase G) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:20676357}. |
| Q13813 | SPTAN1 | S1291 | ochoa | Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. |
| Q14116 | IL18 | S43 | ochoa | Interleukin-18 (IL-18) (Iboctadekin) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma) | Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses (PubMed:10653850). Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators (PubMed:14528293, PubMed:25500532, PubMed:37993714). Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells (PubMed:10653850). Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:33883744). {ECO:0000269|PubMed:10653850, ECO:0000269|PubMed:14528293, ECO:0000269|PubMed:25500532, ECO:0000269|PubMed:33883744, ECO:0000269|PubMed:37993714}. |
| Q14141 | SEPTIN6 | S388 | ochoa | Septin-6 | Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). {ECO:0000269|PubMed:17229681, ECO:0000269|PubMed:17803907, ECO:0000305|PubMed:25588830}. |
| Q14247 | CTTN | S322 | ochoa | Src substrate cortactin (Amplaxin) (Oncogene EMS1) | Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). {ECO:0000250|UniProtKB:Q60598, ECO:0000250|UniProtKB:Q66HL2, ECO:0000269|PubMed:16636290, ECO:0000269|PubMed:17959782, ECO:0000269|PubMed:21296879, ECO:0000269|PubMed:23144454}. |
| Q14494 | NFE2L1 | S599 | psp | Endoplasmic reticulum membrane sensor NFE2L1 (Locus control region-factor 1) (LCR-F1) (Nuclear factor erythroid 2-related factor 1) (NF-E2-related factor 1) (NFE2-related factor 1) (Nuclear factor, erythroid derived 2, like 1) (Protein NRF1, p120 form) (Transcription factor 11) (TCF-11) [Cleaved into: Transcription factor NRF1 (Protein NRF1, p110 form)] | [Endoplasmic reticulum membrane sensor NFE2L1]: Endoplasmic reticulum membrane sensor that translocates into the nucleus in response to various stresses to act as a transcription factor (PubMed:20932482, PubMed:24448410). Constitutes a precursor of the transcription factor NRF1 (By similarity). Able to detect various cellular stresses, such as cholesterol excess, oxidative stress or proteasome inhibition (PubMed:20932482). In response to stress, it is released from the endoplasmic reticulum membrane following cleavage by the protease DDI2 and translocates into the nucleus to form the transcription factor NRF1 (By similarity). Acts as a key sensor of cholesterol excess: in excess cholesterol conditions, the endoplasmic reticulum membrane form of the protein directly binds cholesterol via its CRAC motif, preventing cleavage and release of the transcription factor NRF1, thereby allowing expression of genes promoting cholesterol removal, such as CD36 (By similarity). Involved in proteasome homeostasis: in response to proteasome inhibition, it is released from the endoplasmic reticulum membrane, translocates to the nucleus and activates expression of genes encoding proteasome subunits (PubMed:20932482). {ECO:0000250|UniProtKB:Q61985, ECO:0000269|PubMed:20932482, ECO:0000269|PubMed:24448410}.; FUNCTION: [Transcription factor NRF1]: CNC-type bZIP family transcription factor that translocates to the nucleus and regulates expression of target genes in response to various stresses (PubMed:8932385, PubMed:9421508). Heterodimerizes with small-Maf proteins (MAFF, MAFG or MAFK) and binds DNA motifs including the antioxidant response elements (AREs), which regulate expression of genes involved in oxidative stress response (PubMed:8932385, PubMed:9421508). Activates or represses expression of target genes, depending on the context (PubMed:8932385, PubMed:9421508). Plays a key role in cholesterol homeostasis by acting as a sensor of cholesterol excess: in low cholesterol conditions, translocates into the nucleus and represses expression of genes involved in defense against cholesterol excess, such as CD36 (By similarity). In excess cholesterol conditions, the endoplasmic reticulum membrane form of the protein directly binds cholesterol via its CRAC motif, preventing cleavage and release of the transcription factor NRF1, thereby allowing expression of genes promoting cholesterol removal (By similarity). Critical for redox balance in response to oxidative stress: acts by binding the AREs motifs on promoters and mediating activation of oxidative stress response genes, such as GCLC, GCLM, GSS, MT1 and MT2 (By similarity). Plays an essential role during fetal liver hematopoiesis: probably has a protective function against oxidative stress and is involved in lipid homeostasis in the liver (By similarity). Involved in proteasome homeostasis: in response to proteasome inhibition, mediates the 'bounce-back' of proteasome subunits by translocating into the nucleus and activating expression of genes encoding proteasome subunits (PubMed:20932482). Also involved in regulating glucose flux (By similarity). Together with CEBPB; represses expression of DSPP during odontoblast differentiation (PubMed:15308669). In response to ascorbic acid induction, activates expression of SP7/Osterix in osteoblasts. {ECO:0000250|UniProtKB:Q61985, ECO:0000269|PubMed:15308669, ECO:0000269|PubMed:20932482, ECO:0000269|PubMed:8932385, ECO:0000269|PubMed:9421508}. |
| Q14515 | SPARCL1 | S80 | ochoa | SPARC-like protein 1 (High endothelial venule protein) (Hevin) (MAST 9) | None |
| Q15054 | POLD3 | S423 | ochoa | DNA polymerase delta subunit 3 (DNA polymerase delta subunit C) (DNA polymerase delta subunit p66) (DNA polymerase delta subunit p68) | Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex (PubMed:17317665, PubMed:22801543, PubMed:24449906). As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair. Required for optimal Pol-delta activity. Stabilizes the Pol-delta complex and plays a major role in Pol-delta stimulation by PCNA (PubMed:10219083, PubMed:10852724, PubMed:11595739, PubMed:16510448, PubMed:24035200). Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4 (PubMed:19074196, PubMed:20334433). Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated (PubMed:24035200). Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation. In this context, POLD3, along with PCNA and RFC1-replication factor C complex, is required to recruit POLD1, the catalytic subunit of the polymerase delta complex, to DNA damage sites (PubMed:20227374). Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR) (PubMed:24310611). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites performed by Pol-delta4, independently of DNA polymerase zeta (REV3L) or eta (POLH). Facilitates abasic site bypass by DNA polymerase delta by promoting extension from the nucleotide inserted opposite the lesion (PubMed:19074196, PubMed:25628356, PubMed:27185888). Also involved in TLS, as a component of the tetrameric DNA polymerase zeta complex. Along with POLD2, dramatically increases the efficiency and processivity of DNA synthesis of the DNA polymerase zeta complex compared to the minimal zeta complex, consisting of only REV3L and REV7 (PubMed:24449906). {ECO:0000269|PubMed:10219083, ECO:0000269|PubMed:10852724, ECO:0000269|PubMed:11595739, ECO:0000269|PubMed:16510448, ECO:0000269|PubMed:19074196, ECO:0000269|PubMed:20227374, ECO:0000269|PubMed:20334433, ECO:0000269|PubMed:24035200, ECO:0000269|PubMed:24310611, ECO:0000269|PubMed:24449906, ECO:0000269|PubMed:25628356, ECO:0000269|PubMed:27185888, ECO:0000269|PubMed:38099988}. |
| Q15149 | PLEC | S1721 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q562F6 | SGO2 | S743 | ochoa | Shugoshin 2 (Shugoshin-2) (Shugoshin-like 2) (Tripin) | Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments. Involved in centromeric enrichment of AUKRB in prometaphase. {ECO:0000250, ECO:0000269|PubMed:16541025, ECO:0000269|PubMed:17485487, ECO:0000269|PubMed:20739936}. |
| Q5T8I3 | EEIG2 | S193 | ochoa | EEIG family member 2 (EEIG2) | None |
| Q5VVJ2 | MYSM1 | S581 | ochoa | Deubiquitinase MYSM1 (2A-DUB) (EC 3.4.19.-) (Myb-like, SWIRM and MPN domain-containing protein 1) | Metalloprotease with deubiquitinase activity that plays important regulator roles in hematopoietic stem cell function, blood cell production and immune response (PubMed:24062447, PubMed:26220525, PubMed:28115216). Participates in the normal programming of B-cell responses to antigen after the maturation process (By similarity). Within the cytoplasm, plays critical roles in the repression of innate immunity and autoimmunity (PubMed:33086059). Removes 'Lys-63'-linked polyubiquitins from TRAF3 and TRAF6 complexes (By similarity). Attenuates NOD2-mediated inflammation and tissue injury by promoting 'Lys-63'-linked deubiquitination of RIPK2 component (By similarity). Suppresses the CGAS-STING1 signaling pathway by cleaving STING1 'Lys-63'-linked ubiquitin chains (PubMed:33086059). In the nucleus, acts as a hematopoietic transcription regulator derepressing a range of genes essential for normal stem cell differentiation including EBF1 and PAX5 in B-cells, ID2 in NK-cell progenitor or FLT3 in dendritic cell precursors (PubMed:24062447). Deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, leading to dissociation of histone H1 from the nucleosome (PubMed:17707232). {ECO:0000250|UniProtKB:Q69Z66, ECO:0000269|PubMed:17707232, ECO:0000269|PubMed:22169041, ECO:0000269|PubMed:24062447, ECO:0000269|PubMed:26220525, ECO:0000269|PubMed:28115216, ECO:0000269|PubMed:33086059}. |
| Q68DQ2 | CRYBG3 | S316 | ochoa | Very large A-kinase anchor protein (vlAKAP) (Beta/gamma crystallin domain-containing protein 3) | [Isoform vlAKAP]: Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA). {ECO:0000269|PubMed:25097019}. |
| Q6J9G0 | STYK1 | S91 | ochoa | Tyrosine-protein kinase STYK1 (EC 2.7.10.2) (Novel oncogene with kinase domain) (Protein PK-unique) (Serine/threonine/tyrosine kinase 1) | Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways (By similarity). {ECO:0000250}. |
| Q6PJG6 | BRAT1 | S732 | ochoa | Integrator complex assembly factor BRAT1 (BRCA1-associated ATM activator 1) (BRCA1-associated protein required for ATM activation protein 1) | Component of a multiprotein complex required for the assembly of the RNA endonuclease module of the integrator complex (PubMed:39032489, PubMed:39032490). Associates with INTS9 and INTS11 in the cytoplasm and blocks the active site of INTS11 to inhibit the endonuclease activity of INTS11 before formation of the full integrator complex (PubMed:39032489, PubMed:39032490). Following dissociation of WDR73 of the complex, BRAT1 facilitates the nuclear import of the INTS9-INTS11 heterodimer (PubMed:39032489). In the nucleus, INTS4 is integrated to the INTS9-INTS11 heterodimer and BRAT1 is released from the mature RNA endonuclease module by inositol hexakisphosphate (InsP6) (PubMed:39032489). BRAT1 is also involved in DNA damage response; activates kinases ATM, SMC1A and PRKDC by modulating their phosphorylation status following ionizing radiation (IR) stress (PubMed:16452482, PubMed:22977523). Plays a role in regulating mitochondrial function and cell proliferation (PubMed:25070371). Required for protein stability of MTOR and MTOR-related proteins, and cell cycle progress by growth factors (PubMed:25657994). {ECO:0000269|PubMed:16452482, ECO:0000269|PubMed:22977523, ECO:0000269|PubMed:25070371, ECO:0000269|PubMed:25657994, ECO:0000269|PubMed:39032489, ECO:0000269|PubMed:39032490}. |
| Q6UXG2 | ELAPOR1 | S987 | ochoa | Endosome/lysosome-associated apoptosis and autophagy regulator 1 (Estrogen-induced gene 121 protein) | May protect cells from cell death by inducing cytosolic vacuolization and up-regulating the autophagy pathway (PubMed:21072319). May play a role in apoptosis and cell proliferation through its interaction with HSPA5 (PubMed:26045166). {ECO:0000269|PubMed:21072319, ECO:0000269|PubMed:26045166}. |
| Q6ZWK4 | RHEX | S128 | ochoa | Regulator of hemoglobinization and erythroid cell expansion protein (Regulator of human erythroid cell expansion protein) | Acts as a signaling transduction factor of the EPO-EPOR signaling pathway promoting erythroid cell differentiation (PubMed:25092874). {ECO:0000269|PubMed:25092874}. |
| Q7KZI7 | MARK2 | S30 | ochoa | Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:12429843, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15158914, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:15365179, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:18626018, ECO:0000269|PubMed:20194617, ECO:0000269|PubMed:23666762}. |
| Q7Z6B7 | SRGAP1 | S816 | ochoa | SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho GTPase-activating protein 13) | GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42. {ECO:0000269|PubMed:11672528}. |
| Q86UE4 | MTDH | S494 | ochoa | Protein LYRIC (3D3/LYRIC) (Astrocyte elevated gene-1 protein) (AEG-1) (Lysine-rich CEACAM1 co-isolated protein) (Metadherin) (Metastasis adhesion protein) | Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance. {ECO:0000269|PubMed:15927426, ECO:0000269|PubMed:16452207, ECO:0000269|PubMed:18316612, ECO:0000269|PubMed:19111877}. |
| Q86X40 | LRRC28 | S52 | ochoa | Leucine-rich repeat-containing protein 28 | None |
| Q8IVF7 | FMNL3 | S960 | ochoa | Formin-like protein 3 (Formin homology 2 domain-containing protein 3) (WW domain-binding protein 3) (WBP-3) | Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Required for developmental angiogenesis (By similarity). In this process, required for microtubule reorganization and for efficient endothelial cell elongation. In quiescent endothelial cells, triggers rearrangement of the actin cytoskeleton, but does not alter microtubule alignement. {ECO:0000250|UniProtKB:Q6NXC0, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22275430}. |
| Q8IW50 | FAM219A | S69 | ochoa | Protein FAM219A | None |
| Q8IWV8 | UBR2 | S734 | ochoa | E3 ubiquitin-protein ligase UBR2 (EC 2.3.2.27) (N-recognin-2) (Ubiquitin-protein ligase E3-alpha-2) (Ubiquitin-protein ligase E3-alpha-II) | E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (PubMed:15548684, PubMed:20835242, PubMed:28392261). Recognizes and binds to proteins bearing specific N-terminal residues (N-degrons) that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (PubMed:20835242, PubMed:28392261). Recognizes both type-1 and type-2 N-degrons, containing positively charged amino acids (Arg, Lys and His) and bulky and hydrophobic amino acids, respectively (PubMed:20835242, PubMed:28392261). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:20835242). In contrast, it strongly binds methylated N-degrons (PubMed:28392261). Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A (By similarity). Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth (PubMed:20298436). Required for spermatogenesis, promotes, with Tex19.1, SPO11-dependent recombination foci to accumulate and drive robust homologous chromosome synapsis (By similarity). Polyubiquitinates LINE-1 retrotransposon encoded, LIRE1, which induces degradation, inhibiting LINE-1 retrotransposon mobilization (By similarity). Catalyzes ubiquitination and degradation of the N-terminal part of NLRP1 following NLRP1 activation by pathogens and other damage-associated signals: ubiquitination promotes degradation of the N-terminal part and subsequent release of the cleaved C-terminal part of NLRP1, which polymerizes and forms the NLRP1 inflammasome followed by host cell pyroptosis (By similarity). Plays a role in T-cell receptor signaling by inducing 'Lys-63'-linked ubiquitination of lymphocyte cell-specific kinase LCK (PubMed:38225265). This activity is regulated by DUSP22, which induces 'Lys-48'-linked ubiquitination of UBR2, leading to its proteasomal degradation by SCF E3 ubiquitin-protein ligase complex (PubMed:38225265). {ECO:0000250|UniProtKB:Q6WKZ8, ECO:0000269|PubMed:15548684, ECO:0000269|PubMed:20298436, ECO:0000269|PubMed:20835242, ECO:0000269|PubMed:28392261, ECO:0000269|PubMed:38225265}. |
| Q8N1F7 | NUP93 | S647 | ochoa | Nuclear pore complex protein Nup93 (93 kDa nucleoporin) (Nucleoporin Nup93) | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling (PubMed:26878725). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:15703211, ECO:0000269|PubMed:26878725, ECO:0000269|PubMed:9348540}. |
| Q8N884 | CGAS | S201 | psp | Cyclic GMP-AMP synthase (cGAMP synthase) (cGAS) (h-cGAS) (EC 2.7.7.86) (2'3'-cGAMP synthase) (Mab-21 domain-containing protein 1) | Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (2',3'-cGAMP) from ATP and GTP and plays a key role in innate immunity (PubMed:21478870, PubMed:23258413, PubMed:23707061, PubMed:23707065, PubMed:23722159, PubMed:24077100, PubMed:24116191, PubMed:24462292, PubMed:25131990, PubMed:26300263, PubMed:29976794, PubMed:30799039, PubMed:31142647, PubMed:32814054, PubMed:33273464, PubMed:33542149, PubMed:37217469, PubMed:37802025). Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p] (PubMed:28214358, PubMed:28363908). Acts as a key DNA sensor: directly binds double-stranded DNA (dsDNA), inducing the formation of liquid-like droplets in which CGAS is activated, leading to synthesis of 2',3'-cGAMP, a second messenger that binds to and activates STING1, thereby triggering type-I interferon production (PubMed:28314590, PubMed:28363908, PubMed:29976794, PubMed:32817552, PubMed:33230297, PubMed:33606975, PubMed:35322803, PubMed:35438208, PubMed:35460603, PubMed:35503863). Preferentially recognizes and binds curved long dsDNAs of a minimal length of 40 bp (PubMed:30007416). Acts as a key foreign DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses (PubMed:28363908). Has antiviral activity by sensing the presence of dsDNA from DNA viruses in the cytoplasm (PubMed:28363908, PubMed:35613581). Also acts as an innate immune sensor of infection by retroviruses, such as HIV-2, by detecting the presence of reverse-transcribed DNA in the cytosol (PubMed:23929945, PubMed:24269171, PubMed:30270045, PubMed:32852081). In contrast, HIV-1 is poorly sensed by CGAS, due to its capsid that cloaks viral DNA from CGAS detection (PubMed:24269171, PubMed:30270045, PubMed:32852081). Detection of retroviral reverse-transcribed DNA in the cytosol may be indirect and be mediated via interaction with PQBP1, which directly binds reverse-transcribed retroviral DNA (PubMed:26046437). Also detects the presence of DNA from bacteria, such as M.tuberculosis (PubMed:26048138). 2',3'-cGAMP can be transferred from producing cells to neighboring cells through gap junctions, leading to promote STING1 activation and convey immune response to connecting cells (PubMed:24077100). 2',3'-cGAMP can also be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but STING1-dependent manner (PubMed:26229115). Also senses the presence of neutrophil extracellular traps (NETs) that are translocated to the cytosol following phagocytosis, leading to synthesis of 2',3'-cGAMP (PubMed:33688080). In addition to foreign DNA, can also be activated by endogenous nuclear or mitochondrial DNA (PubMed:28738408, PubMed:28759889, PubMed:31299200, PubMed:33031745, PubMed:33230297). When self-DNA leaks into the cytosol during cellular stress (such as mitochondrial stress, SARS-CoV-2 infection causing severe COVID-19 disease, DNA damage, mitotic arrest or senescence), or is present in form of cytosolic micronuclei, CGAS is activated leading to a state of sterile inflammation (PubMed:28738408, PubMed:28759889, PubMed:31299200, PubMed:33031745, PubMed:33230297, PubMed:35045565). Acts as a regulator of cellular senescence by binding to cytosolic chromatin fragments that are present in senescent cells, leading to trigger type-I interferon production via STING1 and promote cellular senescence (By similarity). Also involved in the inflammatory response to genome instability and double-stranded DNA breaks: acts by localizing to micronuclei arising from genome instability (PubMed:28738408, PubMed:28759889). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, CGAS binds self-DNA exposed to the cytosol, leading to 2',3'-cGAMP synthesis and subsequent activation of STING1 and type-I interferon production (PubMed:28738408, PubMed:28759889). Activated in response to prolonged mitotic arrest, promoting mitotic cell death (PubMed:31299200). In a healthy cell, CGAS is however kept inactive even in cellular events that directly expose it to self-DNA, such as mitosis, when cGAS associates with chromatin directly after nuclear envelope breakdown or remains in the form of postmitotic persistent nuclear cGAS pools bound to chromatin (PubMed:31299200, PubMed:33542149). Nuclear CGAS is inactivated by chromatin via direct interaction with nucleosomes, which block CGAS from DNA binding and thus prevent CGAS-induced autoimmunity (PubMed:31299200, PubMed:32911482, PubMed:32912999, PubMed:33051594, PubMed:33542149). Also acts as a suppressor of DNA repair in response to DNA damage: inhibits homologous recombination repair by interacting with PARP1, the CGAS-PARP1 interaction leading to impede the formation of the PARP1-TIMELESS complex (PubMed:30356214, PubMed:31544964). In addition to DNA, also sense translation stress: in response to translation stress, translocates to the cytosol and associates with collided ribosomes, promoting its activation and triggering type-I interferon production (PubMed:34111399). In contrast to other mammals, human CGAS displays species-specific mechanisms of DNA recognition and produces less 2',3'-cGAMP, allowing a more fine-tuned response to pathogens (PubMed:30007416). {ECO:0000250|UniProtKB:Q8C6L5, ECO:0000269|PubMed:21478870, ECO:0000269|PubMed:23258413, ECO:0000269|PubMed:23707061, ECO:0000269|PubMed:23707065, ECO:0000269|PubMed:23722159, ECO:0000269|PubMed:23929945, ECO:0000269|PubMed:24077100, ECO:0000269|PubMed:24116191, ECO:0000269|PubMed:24269171, ECO:0000269|PubMed:24462292, ECO:0000269|PubMed:25131990, ECO:0000269|PubMed:26046437, ECO:0000269|PubMed:26048138, ECO:0000269|PubMed:26229115, ECO:0000269|PubMed:26300263, ECO:0000269|PubMed:28214358, ECO:0000269|PubMed:28314590, ECO:0000269|PubMed:28363908, ECO:0000269|PubMed:28738408, ECO:0000269|PubMed:28759889, ECO:0000269|PubMed:29976794, ECO:0000269|PubMed:30007416, ECO:0000269|PubMed:30270045, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:30799039, ECO:0000269|PubMed:31142647, ECO:0000269|PubMed:31299200, ECO:0000269|PubMed:31544964, ECO:0000269|PubMed:32814054, ECO:0000269|PubMed:32817552, ECO:0000269|PubMed:32852081, ECO:0000269|PubMed:32911482, ECO:0000269|PubMed:32912999, ECO:0000269|PubMed:33031745, ECO:0000269|PubMed:33051594, ECO:0000269|PubMed:33230297, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33542149, ECO:0000269|PubMed:33606975, ECO:0000269|PubMed:33688080, ECO:0000269|PubMed:34111399, ECO:0000269|PubMed:35045565, ECO:0000269|PubMed:35322803, ECO:0000269|PubMed:35438208, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:35503863, ECO:0000269|PubMed:35613581, ECO:0000269|PubMed:37217469, ECO:0000269|PubMed:37802025}. |
| Q8NEF9 | SRFBP1 | S140 | ochoa | Serum response factor-binding protein 1 (SRF-dependent transcription regulation-associated protein) (p49/STRAP) | May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells (By similarity). {ECO:0000250|UniProtKB:Q9CZ91}. |
| Q8NEF9 | SRFBP1 | S367 | ochoa | Serum response factor-binding protein 1 (SRF-dependent transcription regulation-associated protein) (p49/STRAP) | May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells (By similarity). {ECO:0000250|UniProtKB:Q9CZ91}. |
| Q8NEY1 | NAV1 | S140 | ochoa | Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) | May be involved in neuronal migration. {ECO:0000250}. |
| Q8NEY8 | PPHLN1 | S325 | ochoa | Periphilin-1 (CDC7 expression repressor) (CR) (Gastric cancer antigen Ga50) | Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3. In the HUSH complex, contributes to the maintenance of the complex at chromatin (PubMed:26022416). Acts as a transcriptional corepressor and regulates the cell cycle, probably via the HUSH complex (PubMed:15474462, PubMed:17963697). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). May be involved in epithelial differentiation by contributing to epidermal integrity and barrier formation (PubMed:12853457). {ECO:0000269|PubMed:15474462, ECO:0000269|PubMed:17963697, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:30487602, ECO:0000305|PubMed:12853457}. |
| Q8NG31 | KNL1 | S153 | ochoa | Outer kinetochore KNL1 complex subunit KNL1 (ALL1-fused gene from chromosome 15q14 protein) (AF15q14) (Bub-linking kinetochore protein) (Blinkin) (Cancer susceptibility candidate gene 5 protein) (Cancer/testis antigen 29) (CT29) (Kinetochore scaffold 1) (Kinetochore-null protein 1) (Protein CASC5) (Protein D40/AF15q14) | Acts as a component of the outer kinetochore KNL1 complex that serves as a docking point for spindle assembly checkpoint components and mediates microtubule-kinetochore interactions (PubMed:15502821, PubMed:17981135, PubMed:18045986, PubMed:19893618, PubMed:21199919, PubMed:22000412, PubMed:22331848, PubMed:27881301, PubMed:30100357). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules (PubMed:18045986, PubMed:19893618, PubMed:27881301). The outer kinetochore is made up of the ten-subunit KMN network, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:38459127, PubMed:38459128). Required for kinetochore binding by a distinct subset of kMAPs (kinetochore-bound microtubule-associated proteins) and motors (PubMed:19893618). Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore (PubMed:18045986, PubMed:27881301). Can bind either to microtubules or to the protein phosphatase 1 (PP1) catalytic subunits PPP1CA and PPP1CC (via overlapping binding sites), it has higher affinity for PP1 (PubMed:30100357). Recruits MAD2L1 to the kinetochore and also directly links BUB1 and BUB1B to the kinetochore (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:22331848, PubMed:25308863). In addition to orienting mitotic chromosomes, it is also essential for alignment of homologous chromosomes during meiotic metaphase I (By similarity). In meiosis I, required to activate the spindle assembly checkpoint at unattached kinetochores to correct erroneous kinetochore-microtubule attachments (By similarity). {ECO:0000250|UniProtKB:Q66JQ7, ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:17981135, ECO:0000269|PubMed:18045986, ECO:0000269|PubMed:19893618, ECO:0000269|PubMed:21199919, ECO:0000269|PubMed:22000412, ECO:0000269|PubMed:22331848, ECO:0000269|PubMed:25308863, ECO:0000269|PubMed:27881301, ECO:0000269|PubMed:30100357, ECO:0000269|PubMed:38459127, ECO:0000269|PubMed:38459128}. |
| Q8NG31 | KNL1 | S956 | ochoa | Outer kinetochore KNL1 complex subunit KNL1 (ALL1-fused gene from chromosome 15q14 protein) (AF15q14) (Bub-linking kinetochore protein) (Blinkin) (Cancer susceptibility candidate gene 5 protein) (Cancer/testis antigen 29) (CT29) (Kinetochore scaffold 1) (Kinetochore-null protein 1) (Protein CASC5) (Protein D40/AF15q14) | Acts as a component of the outer kinetochore KNL1 complex that serves as a docking point for spindle assembly checkpoint components and mediates microtubule-kinetochore interactions (PubMed:15502821, PubMed:17981135, PubMed:18045986, PubMed:19893618, PubMed:21199919, PubMed:22000412, PubMed:22331848, PubMed:27881301, PubMed:30100357). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules (PubMed:18045986, PubMed:19893618, PubMed:27881301). The outer kinetochore is made up of the ten-subunit KMN network, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:38459127, PubMed:38459128). Required for kinetochore binding by a distinct subset of kMAPs (kinetochore-bound microtubule-associated proteins) and motors (PubMed:19893618). Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore (PubMed:18045986, PubMed:27881301). Can bind either to microtubules or to the protein phosphatase 1 (PP1) catalytic subunits PPP1CA and PPP1CC (via overlapping binding sites), it has higher affinity for PP1 (PubMed:30100357). Recruits MAD2L1 to the kinetochore and also directly links BUB1 and BUB1B to the kinetochore (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:22331848, PubMed:25308863). In addition to orienting mitotic chromosomes, it is also essential for alignment of homologous chromosomes during meiotic metaphase I (By similarity). In meiosis I, required to activate the spindle assembly checkpoint at unattached kinetochores to correct erroneous kinetochore-microtubule attachments (By similarity). {ECO:0000250|UniProtKB:Q66JQ7, ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:17981135, ECO:0000269|PubMed:18045986, ECO:0000269|PubMed:19893618, ECO:0000269|PubMed:21199919, ECO:0000269|PubMed:22000412, ECO:0000269|PubMed:22331848, ECO:0000269|PubMed:25308863, ECO:0000269|PubMed:27881301, ECO:0000269|PubMed:30100357, ECO:0000269|PubMed:38459127, ECO:0000269|PubMed:38459128}. |
| Q8TF40 | FNIP1 | S614 | ochoa | Folliculin-interacting protein 1 | Binding partner of the GTPase-activating protein FLCN: involved in the cellular response to amino acid availability by regulating the non-canonical mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3 (PubMed:17028174, PubMed:18663353, PubMed:24081491, PubMed:37079666). Required to promote FLCN recruitment to lysosomes and interaction with Rag GTPases, leading to activation of the non-canonical mTORC1 signaling (PubMed:24081491). In low-amino acid conditions, component of the lysosomal folliculin complex (LFC) on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, thereby inactivating mTORC1 and promoting nuclear translocation of TFEB and TFE3 (By similarity). Upon amino acid restimulation, disassembly of the LFC complex liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent inactivation of TFEB and TFE3 (PubMed:37079666). Together with FLCN, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy (PubMed:25126726). In addition to its role in mTORC1 signaling, also acts as a co-chaperone of HSP90AA1/Hsp90: following gradual phosphorylation by CK2, inhibits the ATPase activity of HSP90AA1/Hsp90, leading to activate both kinase and non-kinase client proteins of HSP90AA1/Hsp90 (PubMed:27353360, PubMed:30699359). Acts as a scaffold to load client protein FLCN onto HSP90AA1/Hsp90 (PubMed:27353360). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360). Also acts as a core component of the reductive stress response by inhibiting activation of mitochondria in normal conditions: in response to reductive stress, the conserved Cys degron is reduced, leading to recognition and polyubiquitylation by the CRL2(FEM1B) complex, followed by proteasomal (By similarity). Required for B-cell development (PubMed:32905580). {ECO:0000250|UniProtKB:Q68FD7, ECO:0000250|UniProtKB:Q9P278, ECO:0000269|PubMed:17028174, ECO:0000269|PubMed:18663353, ECO:0000269|PubMed:24081491, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:30699359, ECO:0000269|PubMed:32905580, ECO:0000269|PubMed:37079666}. |
| Q8WUM9 | SLC20A1 | S277 | ochoa | Sodium-dependent phosphate transporter 1 (Gibbon ape leukemia virus receptor 1) (GLVR-1) (Leukemia virus receptor 1 homolog) (Phosphate transporter 1) (PiT-1) (Solute carrier family 20 member 1) | Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:11009570, PubMed:16790504, PubMed:17494632, PubMed:19726692, PubMed:7929240, PubMed:8041748). May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification (PubMed:11009570). Essential for cell proliferation but this function is independent of its phosphate transporter activity (PubMed:19726692). {ECO:0000269|PubMed:11009570, ECO:0000269|PubMed:16790504, ECO:0000269|PubMed:17494632, ECO:0000269|PubMed:19726692, ECO:0000269|PubMed:7929240, ECO:0000269|PubMed:8041748}.; FUNCTION: (Microbial infection) May function as a retroviral receptor as it confers human cells susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B) as well as 10A1 murine leukemia virus (10A1 MLV). {ECO:0000269|PubMed:12097582, ECO:0000269|PubMed:1309898, ECO:0000269|PubMed:2078500, ECO:0000269|PubMed:7966619}. |
| Q8WVS4 | DYNC2I1 | S247 | ochoa | Cytoplasmic dynein 2 intermediate chain 1 (Dynein 2 intermediate chain 1) (WD repeat-containing protein 60) | Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system (PubMed:23910462, PubMed:25205765, PubMed:29742051, PubMed:31451806). DYNC2I1 plays a major role in retrograde ciliary protein trafficking in cilia and flagella (PubMed:29742051, PubMed:30320547, PubMed:30649997). Also requires to maintain a functional transition zone (PubMed:30320547). {ECO:0000269|PubMed:23910462, ECO:0000269|PubMed:25205765, ECO:0000269|PubMed:29742051, ECO:0000269|PubMed:30320547, ECO:0000269|PubMed:30649997, ECO:0000269|PubMed:31451806}. |
| Q8WXX5 | DNAJC9 | S109 | ochoa | DnaJ homolog subfamily C member 9 (HDJC9) (DnaJ protein SB73) | Acts as a dual histone chaperone and heat shock co-chaperone (PubMed:33857403). As a histone chaperone, forms a co-chaperone complex with MCM2 and histone H3-H4 heterodimers; and may thereby assist MCM2 in histone H3-H4 heterodimer recognition and facilitate the assembly of histones into nucleosomes (PubMed:33857403). May also act as a histone co-chaperone together with TONSL (PubMed:33857403). May recruit histone chaperones ASF1A, NASP and SPT2 to histone H3-H4 heterodimers (PubMed:33857403). Also plays a role as co-chaperone of the HSP70 family of molecular chaperone proteins, such as HSPA1A, HSPA1B and HSPA8 (PubMed:17182002, PubMed:33857403). As a co-chaperone, may play a role in the recruitment of HSP70-type molecular chaperone machinery to histone H3-H4 substrates, thereby maintaining the histone structural integrity (PubMed:33857403). Exhibits activity to assemble histones onto DNA in vitro (PubMed:33857403). {ECO:0000269|PubMed:17182002, ECO:0000269|PubMed:33857403}. |
| Q92541 | RTF1 | S652 | ochoa | RNA polymerase-associated protein RTF1 homolog | Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Binds single-stranded DNA. Required for maximal induction of heat-shock genes. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of a SET1 complex (By similarity). {ECO:0000250, ECO:0000269|PubMed:19345177, ECO:0000269|PubMed:20178742}. |
| Q92608 | DOCK2 | Y985 | psp | Dedicator of cytokinesis protein 2 | Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2. {ECO:0000269|PubMed:21613211}. |
| Q92793 | CREBBP | S437 | psp | CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-) | Acetylates histones, giving a specific tag for transcriptional activation (PubMed:21131905, PubMed:24616510). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:24207024, PubMed:28790157, PubMed:30540930, PubMed:35675826, PubMed:9707565). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as lactoyl-CoA, and is able to mediate protein lactylation (PubMed:38128537). Catalyzes lactylation of MRE11 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR) (PubMed:38128537). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000269|PubMed:10490106, ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:24616510, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:30540930, ECO:0000269|PubMed:35675826, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9707565}. |
| Q969S3 | ZNF622 | S78 | ochoa | Cytoplasmic 60S subunit biogenesis factor ZNF622 (Zinc finger protein 622) (Zinc finger-like protein 9) | Pre-60S-associated cytoplasmic factor involved in the cytoplasmic maturation of the 60S subunit. {ECO:0000269|PubMed:33711283}. |
| Q969S3 | ZNF622 | S314 | psp | Cytoplasmic 60S subunit biogenesis factor ZNF622 (Zinc finger protein 622) (Zinc finger-like protein 9) | Pre-60S-associated cytoplasmic factor involved in the cytoplasmic maturation of the 60S subunit. {ECO:0000269|PubMed:33711283}. |
| Q96C24 | SYTL4 | S180 | ochoa | Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin) | Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By similarity). {ECO:0000250}. |
| Q96QT4 | TRPM7 | S1695 | psp | Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form] | Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644). {ECO:0000250|UniProtKB:Q923J1, ECO:0000269|PubMed:11385574, ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:18365021, ECO:0000269|PubMed:18394644, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:35561741, ECO:0000269|PubMed:36027648}.; FUNCTION: [TRPM7 channel, cleaved form]: The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling. {ECO:0000250|UniProtKB:Q923J1}.; FUNCTION: [TRPM7 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development. {ECO:0000250|UniProtKB:Q923J1}. |
| Q96RG2 | PASK | S1273 | ochoa | PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (hPASK) (EC 2.7.11.1) | Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation. {ECO:0000269|PubMed:16275910, ECO:0000269|PubMed:17052199, ECO:0000269|PubMed:17595531, ECO:0000269|PubMed:20943661, ECO:0000269|PubMed:21181396, ECO:0000269|PubMed:21418524}. |
| Q96S59 | RANBP9 | S534 | ochoa | Ran-binding protein 9 (RanBP9) (BPM-L) (BPM90) (Ran-binding protein M) (RanBPM) (RanBP7) | May act as scaffolding protein, and as adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Acts as a mediator of cell spreading and actin cytoskeleton rearrangement (PubMed:18710924). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). May be involved in signaling of ITGB2/LFA-1 and other integrins (PubMed:14722085). Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway (PubMed:12147692). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation (PubMed:12361945, PubMed:18222118). Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity (PubMed:15558019). Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA. {ECO:0000269|PubMed:12147692, ECO:0000269|PubMed:12361945, ECO:0000269|PubMed:14500717, ECO:0000269|PubMed:14722085, ECO:0000269|PubMed:15381419, ECO:0000269|PubMed:15558019, ECO:0000269|PubMed:18222118, ECO:0000269|PubMed:18710924, ECO:0000269|PubMed:29911972, ECO:0000305}. |
| Q96T17 | MAP7D2 | S636 | ochoa | MAP7 domain-containing protein 2 | Microtubule-stabilizing protein that plays a role in the control of cell motility and neurite outgrowth via direct binding to the microtubule (By similarity). Acts as a critical cofactor for kinesin transport. In the proximal axon, regulates kinesin-1 family members, KIF5A, KIF5B and KIF5C recruitment to microtubules and contributes to kinesin-1-mediated transport in the axons (By similarity). {ECO:0000250|UniProtKB:A2AG50, ECO:0000250|UniProtKB:D4A4L4}. |
| Q96T58 | SPEN | S1194 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q99567 | NUP88 | S379 | ochoa | Nuclear pore complex protein Nup88 (88 kDa nucleoporin) (Nucleoporin Nup88) | Component of nuclear pore complex. {ECO:0000269|PubMed:30543681}. |
| Q99572 | P2RX7 | S390 | ochoa | P2X purinoceptor 7 (P2X7) (ATP receptor) (P2Z receptor) (Purinergic receptor) | ATP-gated nonselective transmembrane cation channel that requires high millimolar concentrations of ATP for activation (PubMed:17483156, PubMed:25281740, PubMed:9038151). Upon ATP binding, it rapidly opens to allow the influx of small cations Na(+) and Ca(2+), and the K(+) efflux (PubMed:17483156, PubMed:20453110, PubMed:28235784, PubMed:39262850). Also has the ability to form a large pore in the cell membrane, allowing the passage of large cationic molecules (PubMed:17483156). In microglia, may mediate NADPH transport across the plasma membrane (PubMed:39142135). In immune cells, P2RX7 acts as a molecular sensor in pathological inflammatory states by detecting and responding to high local concentrations of extracellar ATP. In microglial cells, P2RX7 activation leads to the release of pro-inflammatory cytokines, such as IL-1beta and IL-18, through the activation of the NLRP3 inflammasome and caspase-1 (PubMed:26877061). Cooperates with KCNK6 to activate NLRP3 inflammasome (By similarity). Activates death pathways leading to apoptosis and autophagy (PubMed:21821797, PubMed:23303206, PubMed:28326637). Activates death pathways leading to pyroptosis (By similarity). {ECO:0000250|UniProtKB:Q9Z1M0, ECO:0000269|PubMed:17483156, ECO:0000269|PubMed:20453110, ECO:0000269|PubMed:21821797, ECO:0000269|PubMed:23303206, ECO:0000269|PubMed:25281740, ECO:0000269|PubMed:26877061, ECO:0000269|PubMed:28235784, ECO:0000269|PubMed:28326637, ECO:0000269|PubMed:39142135, ECO:0000269|PubMed:39262850, ECO:0000269|PubMed:9038151}.; FUNCTION: [Isoform B]: Shows ion channel activity but no macropore function. {ECO:0000269|PubMed:20453110}.; FUNCTION: [Isoform H]: Non-functional channel. {ECO:0000269|PubMed:15896293}.; FUNCTION: [Isoform J]: Non-functional channel. {ECO:0000269|PubMed:16624800}. |
| Q99590 | SCAF11 | S687 | ochoa | Protein SCAF11 (CTD-associated SR protein 11) (Renal carcinoma antigen NY-REN-40) (SC35-interacting protein 1) (SR-related and CTD-associated factor 11) (SRSF2-interacting protein) (Serine/arginine-rich splicing factor 2-interacting protein) (Splicing factor, arginine/serine-rich 2-interacting protein) (Splicing regulatory protein 129) (SRrp129) | Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly. {ECO:0000269|PubMed:9447963}. |
| Q99613 | EIF3C | S865 | ochoa | Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 subunit 8) (eIF3 p110) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03002, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
| Q99933 | BAG1 | S223 | ochoa | BAG family molecular chaperone regulator 1 (BAG-1) (Bcl-2-associated athanogene 1) | Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 (PubMed:24318877, PubMed:27474739, PubMed:9873016). Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity (PubMed:12724406). Markedly increases the anti-cell death function of BCL2 induced by various stimuli (PubMed:9305631). Involved in the STUB1-mediated proteasomal degradation of ESR1 in response to age-related circulating estradiol (17-beta-estradiol/E2) decline, thereby promotes neuronal apoptosis in response to ischemic reperfusion injury (By similarity). {ECO:0000250|UniProtKB:B0K019, ECO:0000269|PubMed:12724406, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:9305631, ECO:0000269|PubMed:9873016}. |
| Q9BPZ7 | MAPKAP1 | S343 | psp | Target of rapamycin complex 2 subunit MAPKAP1 (TORC2 subunit MAPKAP1) (Mitogen-activated protein kinase 2-associated protein 1) (Stress-activated map kinase-interacting protein 1) (SAPK-interacting protein 1) (mSIN1) | Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15467718, PubMed:16919458, PubMed:16962653, PubMed:17043309, PubMed:21806543, PubMed:28264193, PubMed:28968999, PubMed:30837283, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:16919458, PubMed:16962653, PubMed:21806543, PubMed:28264193, PubMed:28968999, PubMed:30837283, PubMed:35926713). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:16962653). Within the mTORC2 complex, MAPKAP1/SIN1 acts as a substrate adapter which recognizes and binds AGC protein kinase family members for phosphorylation by MTOR (PubMed:21806543, PubMed:28264193). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:28264193, PubMed:35926713). mTORC2 catalyzes the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657' (PubMed:30837283, PubMed:35926713). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:15467718). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (PubMed:15467718). MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation (PubMed:15988011). Inhibits HRAS and KRAS independently of mTORC2 complex (PubMed:17303383, PubMed:34380736, PubMed:35522713). Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription (PubMed:17054722). Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex (PubMed:23727834). {ECO:0000250|UniProtKB:Q8BKH7, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15988011, ECO:0000269|PubMed:16919458, ECO:0000269|PubMed:16962653, ECO:0000269|PubMed:17043309, ECO:0000269|PubMed:17054722, ECO:0000269|PubMed:17303383, ECO:0000269|PubMed:21806543, ECO:0000269|PubMed:23727834, ECO:0000269|PubMed:28264193, ECO:0000269|PubMed:28968999, ECO:0000269|PubMed:30837283, ECO:0000269|PubMed:34380736, ECO:0000269|PubMed:35522713, ECO:0000269|PubMed:35926713}.; FUNCTION: [Isoform 4]: In contrast to isoform 1, isoform 2 and isoform 6, isoform 4 is not a component of the a mTORC2 complex. {ECO:0000269|PubMed:26263164}. |
| Q9BXF9 | TEKT3 | S465 | ochoa | Tektin-3 | Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme (PubMed:36191189). Forms filamentous polymers in the walls of ciliary and flagellar microtubules (By similarity). Required for normal sperm mobility (By similarity). {ECO:0000250|UniProtKB:A6H782, ECO:0000250|UniProtKB:Q6X6Z7, ECO:0000269|PubMed:36191189}. |
| Q9BYB0 | SHANK3 | S1613 | ochoa | SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) | Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. {ECO:0000269|PubMed:24132240}. |
| Q9BYW2 | SETD2 | S744 | ochoa | Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) | Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}. |
| Q9H2P0 | ADNP | S1032 | ochoa | Activity-dependent neuroprotector homeobox protein (Activity-dependent neuroprotective protein) | May be involved in transcriptional regulation. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Positively modulates WNT-beta-catenin/CTNN1B signaling, acting by regulating phosphorylation of, and thereby stabilizing, CTNNB1. May be required for neural induction and neuronal differentiation. May be involved in erythroid differentiation (By similarity). {ECO:0000250|UniProtKB:Q9Z103}. |
| Q9H799 | CPLANE1 | S2762 | ochoa | Ciliogenesis and planar polarity effector 1 (Protein JBTS17) | Involved in ciliogenesis (PubMed:25877302, PubMed:35582950). Involved in the establishment of cell polarity required for directional cell migration. Proposed to act in association with the CPLANE (ciliogenesis and planar polarity effectors) complex. Involved in recruitment of peripheral IFT-A proteins to basal bodies (By similarity). {ECO:0000250|UniProtKB:Q8CE72, ECO:0000269|PubMed:35582950, ECO:0000305|PubMed:25877302}. |
| Q9NQ84 | GPRC5C | S344 | ochoa | G-protein coupled receptor family C group 5 member C (Retinoic acid-induced gene 3 protein) (RAIG-3) | This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways. {ECO:0000250}. |
| Q9NQ84 | GPRC5C | S383 | ochoa | G-protein coupled receptor family C group 5 member C (Retinoic acid-induced gene 3 protein) (RAIG-3) | This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways. {ECO:0000250}. |
| Q9NU19 | TBC1D22B | S57 | ochoa | TBC1 domain family member 22B | May act as a GTPase-activating protein for Rab family protein(s). {ECO:0000250}. |
| Q9P0K7 | RAI14 | S358 | ochoa | Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14) | Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier. {ECO:0000250|UniProtKB:Q5U312}. |
| Q9P2D6 | FAM135A | S707 | ochoa | Protein FAM135A | None |
| Q9P2T1 | GMPR2 | S28 | ochoa | GMP reductase 2 (GMPR 2) (EC 1.7.1.7) (Guanosine 5'-monophosphate oxidoreductase 2) (Guanosine monophosphate reductase 2) | Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (PubMed:12009299, PubMed:12669231, PubMed:16359702, PubMed:22037469). Plays a role in modulating cellular differentiation (PubMed:12669231). {ECO:0000255|HAMAP-Rule:MF_03195, ECO:0000269|PubMed:12009299, ECO:0000269|PubMed:12669231, ECO:0000269|PubMed:16359702, ECO:0000269|PubMed:22037469}. |
| Q9UKF6 | CPSF3 | S633 | ochoa | Cleavage and polyadenylation specificity factor subunit 3 (EC 3.1.27.-) (Cleavage and polyadenylation specificity factor 73 kDa subunit) (CPSF 73 kDa subunit) (mRNA 3'-end-processing endonuclease CPSF-73) | Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity, and functions as an mRNA 3'-end-processing endonuclease (PubMed:30507380). Also involved in the histone 3'-end pre-mRNA processing (PubMed:30507380). U7 snRNP-dependent protein that induces both the 3'-endoribonucleolytic cleavage of histone pre-mRNAs and acts as a 5' to 3' exonuclease for degrading the subsequent downstream cleavage product (DCP) of mature histone mRNAs. Cleavage occurs after the 5'-ACCCA-3' sequence in the histone pre-mRNA leaving a 3'hydroxyl group on the upstream fragment containing the stem loop (SL) and 5' phosphate on the downstream cleavage product (DCP) starting with CU nucleotides. The U7-dependent 5' to 3' exonuclease activity is processive and degrades the DCP RNA substrate even after complete removal of the U7-binding site. Binds to the downstream cleavage product (DCP) of histone pre-mRNAs and the cleaved DCP RNA substrate in a U7 snRNP dependent manner. Required for entering/progressing through S-phase of the cell cycle (PubMed:30507380). Required for the selective processing of microRNAs (miRNAs) during embryonic stem cell differentiation via its interaction with ISY1 (By similarity). Required for the biogenesis of all miRNAs from the pri-miR-17-92 primary transcript except miR-92a (By similarity). Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290-295 and pri-miR-96-183 primary transcripts, respectively (By similarity). {ECO:0000250|UniProtKB:Q9QXK7, ECO:0000269|PubMed:14749727, ECO:0000269|PubMed:15037765, ECO:0000269|PubMed:17128255, ECO:0000269|PubMed:18688255, ECO:0000269|PubMed:30507380}. |
| Q9UKV3 | ACIN1 | S863 | ochoa | Apoptotic chromatin condensation inducer in the nucleus (Acinus) | Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}. |
| Q9ULP9 | TBC1D24 | S28 | ochoa | TBC1 domain family member 24 | May act as a GTPase-activating protein for Rab family protein(s) (PubMed:20727515, PubMed:20797691). Involved in neuronal projections development, probably through a negative modulation of ARF6 function (PubMed:20727515). Involved in the regulation of synaptic vesicle trafficking (PubMed:31257402). {ECO:0000269|PubMed:20727515, ECO:0000269|PubMed:20797691, ECO:0000269|PubMed:31257402}. |
| Q9UPN3 | MACF1 | S5009 | ochoa | Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) | [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250|UniProtKB:Q9QXZ0, ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:27693509}. |
| Q9Y5B9 | SUPT16H | S188 | ochoa | FACT complex subunit SPT16 (Chromatin-specific transcription elongation factor 140 kDa subunit) (FACT 140 kDa subunit) (FACTp140) (Facilitates chromatin transcription complex subunit SPT16) (hSPT16) | Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). {ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:12934006, ECO:0000269|PubMed:16713563, ECO:0000269|PubMed:9489704, ECO:0000269|PubMed:9836642}. |
| Q9Y5K6 | CD2AP | S256 | ochoa | CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains) | Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton (PubMed:10339567). In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation (By similarity). May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell (By similarity). May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis (PubMed:15800069). Plays a role in epithelial cell junctions formation (PubMed:22891260). {ECO:0000250|UniProtKB:F1LRS8, ECO:0000250|UniProtKB:Q9JLQ0, ECO:0000269|PubMed:10339567, ECO:0000269|PubMed:15800069, ECO:0000269|PubMed:22891260}. |
| Q9Y6A5 | TACC3 | S524 | ochoa | Transforming acidic coiled-coil-containing protein 3 (ERIC-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476). {ECO:0000250|UniProtKB:Q9JJ11, ECO:0000269|PubMed:14767476, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}. |
| P83731 | RPL24 | S38 | Sugiyama | Large ribosomal subunit protein eL24 (60S ribosomal protein L24) (60S ribosomal protein L30) | Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| O95678 | KRT75 | S162 | Sugiyama | Keratin, type II cytoskeletal 75 (Cytokeratin-75) (CK-75) (Keratin-6 hair follicle) (hK6hf) (Keratin-75) (K75) (Type II keratin-K6hf) (Type-II keratin Kb18) | Plays a central role in hair and nail formation. Essential component of keratin intermediate filaments in the companion layer of the hair follicle. |
| P02538 | KRT6A | S176 | Sugiyama | Keratin, type II cytoskeletal 6A (Cytokeratin-6A) (CK-6A) (Cytokeratin-6D) (CK-6D) (Keratin-6A) (K6A) (Type-II keratin Kb6) (allergen Hom s 5) | Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair. {ECO:0000250|UniProtKB:P50446}. |
| P04259 | KRT6B | S176 | Sugiyama | Keratin, type II cytoskeletal 6B (Cytokeratin-6B) (CK-6B) (Keratin-6B) (K6B) (Type-II keratin Kb10) | None |
| P05787 | KRT8 | S104 | Sugiyama | Keratin, type II cytoskeletal 8 (Cytokeratin-8) (CK-8) (Keratin-8) (K8) (Type-II keratin Kb8) | Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. {ECO:0000269|PubMed:16000376}. |
| P08729 | KRT7 | S104 | Sugiyama | Keratin, type II cytoskeletal 7 (Cytokeratin-7) (CK-7) (Keratin-7) (K7) (Sarcolectin) (Type-II keratin Kb7) | Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7). {ECO:0000269|PubMed:10492017, ECO:0000269|PubMed:12072504}. |
| P12035 | KRT3 | S211 | Sugiyama | Keratin, type II cytoskeletal 3 (65 kDa cytokeratin) (Cytokeratin-3) (CK-3) (Keratin-3) (K3) (Type-II keratin Kb3) | None |
| P13647 | KRT5 | S181 | Sugiyama | Keratin, type II cytoskeletal 5 (58 kDa cytokeratin) (Cytokeratin-5) (CK-5) (Keratin-5) (K5) (Type-II keratin Kb5) | Required for the formation of keratin intermediate filaments in the basal epidermis and maintenance of the skin barrier in response to mechanical stress (By similarity). Regulates the recruitment of Langerhans cells to the epidermis, potentially by modulation of the abundance of macrophage chemotactic cytokines, macrophage inflammatory cytokines and CTNND1 localization in keratinocytes (By similarity). {ECO:0000250|UniProtKB:Q922U2}. |
| P35908 | KRT2 | S191 | Sugiyama | Keratin, type II cytoskeletal 2 epidermal (Cytokeratin-2e) (CK-2e) (Epithelial keratin-2e) (Keratin-2 epidermis) (Keratin-2e) (K2e) (Type-II keratin Kb2) | Probably contributes to terminal cornification (PubMed:1380918). Associated with keratinocyte activation, proliferation and keratinization (PubMed:12598329). Required for maintenance of corneocytes and keratin filaments in suprabasal keratinocytes in the epidermis of the ear, potentially via moderation of expression and localization of keratins and their partner proteins (By similarity). Plays a role in the establishment of the epidermal barrier on plantar skin (By similarity). {ECO:0000250|UniProtKB:Q3TTY5, ECO:0000269|PubMed:12598329, ECO:0000269|PubMed:1380918}. |
| P48668 | KRT6C | S176 | Sugiyama | Keratin, type II cytoskeletal 6C (Cytokeratin-6C) (CK-6C) (Cytokeratin-6E) (CK-6E) (Keratin K6h) (Keratin-6C) (K6C) (Type-II keratin Kb12) | None |
| Q01546 | KRT76 | S196 | Sugiyama | Keratin, type II cytoskeletal 2 oral (Cytokeratin-2P) (CK-2P) (K2P) (Keratin-76) (K76) (Type-II keratin Kb9) | Probably contributes to terminal cornification. {ECO:0000269|PubMed:1282112}. |
| Q14CN4 | KRT72 | S138 | Sugiyama | Keratin, type II cytoskeletal 72 (Cytokeratin-72) (CK-72) (Keratin-72) (K72) (Type II inner root sheath-specific keratin-K6irs2) (Type-II keratin Kb35) | Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable). {ECO:0000305}. |
| Q3SY84 | KRT71 | S143 | Sugiyama | Keratin, type II cytoskeletal 71 (Cytokeratin-71) (CK-71) (Keratin-71) (K71) (Type II inner root sheath-specific keratin-K6irs1) (Keratin 6 irs) (hK6irs) (hK6irs1) (Type-II keratin Kb34) | Plays a central role in hair formation. Essential component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle. {ECO:0000269|PubMed:22592156}. |
| Q5XKE5 | KRT79 | S155 | Sugiyama | Keratin, type II cytoskeletal 79 (Cytokeratin-79) (CK-79) (Keratin-6-like) (Keratin-6L) (Keratin-79) (K79) (Type-II keratin Kb38) | None |
| Q7RTS7 | KRT74 | S153 | Sugiyama | Keratin, type II cytoskeletal 74 (Cytokeratin-74) (CK-74) (Keratin-5c) (K5C) (Keratin-74) (K74) (Type II inner root sheath-specific keratin-K6irs4) (Type-II keratin Kb37) | Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable). {ECO:0000305}. |
| Q7Z794 | KRT77 | S177 | Sugiyama | Keratin, type II cytoskeletal 1b (Cytokeratin-1B) (CK-1B) (Keratin-77) (K77) (Type-II keratin Kb39) | None |
| Q86Y46 | KRT73 | S145 | Sugiyama | Keratin, type II cytoskeletal 73 (Cytokeratin-73) (CK-73) (Keratin-73) (K73) (Type II inner root sheath-specific keratin-K6irs3) (Type-II keratin Kb36) | Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable). {ECO:0000305}. |
| Q9NSB2 | KRT84 | S178 | Sugiyama | Keratin, type II cuticular Hb4 (Keratin-84) (K84) (Type II hair keratin Hb4) (Type-II keratin Kb24) | None |
| P05783 | KRT18 | S93 | Sugiyama | Keratin, type I cytoskeletal 18 (Cell proliferation-inducing gene 46 protein) (Cytokeratin-18) (CK-18) (Keratin-18) (K18) | Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. {ECO:0000250, ECO:0000269|PubMed:15529338, ECO:0000269|PubMed:16424149, ECO:0000269|PubMed:17213200, ECO:0000269|PubMed:7523419, ECO:0000269|PubMed:8522591, ECO:0000269|PubMed:9298992, ECO:0000269|PubMed:9524113}. |
| P39748 | FEN1 | S255 | Sugiyama | Flap endonuclease 1 (FEN-1) (EC 3.1.-.-) (DNase IV) (Flap structure-specific endonuclease 1) (Maturation factor 1) (MF1) (hFEN-1) | Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA. {ECO:0000255|HAMAP-Rule:MF_03140, ECO:0000269|PubMed:10744741, ECO:0000269|PubMed:11986308, ECO:0000269|PubMed:18443037, ECO:0000269|PubMed:20729856, ECO:0000269|PubMed:26751069, ECO:0000269|PubMed:7961795, ECO:0000269|PubMed:8621570}. |
| O43715 | TRIAP1 | S32 | Sugiyama | TP53-regulated inhibitor of apoptosis 1 (Protein 15E1.1) (WF-1) (p53-inducible cell-survival factor) (p53CSV) | Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane (PubMed:23931759). Likewise, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes (in vitro) and probably functions as a PA transporter across the mitochondrion intermembrane space (in vivo) (PubMed:26071602). Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis (PubMed:15735003). {ECO:0000269|PubMed:15735003, ECO:0000269|PubMed:23931759, ECO:0000269|PubMed:26071602}. |
| P25786 | PSMA1 | S211 | Sugiyama | Proteasome subunit alpha type-1 (30 kDa prosomal protein) (PROS-30) (Macropain subunit C2) (Multicatalytic endopeptidase complex subunit C2) (Proteasome component C2) (Proteasome nu chain) (Proteasome subunit alpha-6) (alpha-6) | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. |
| O15146 | MUSK | S567 | Sugiyama | Muscle, skeletal receptor tyrosine-protein kinase (EC 2.7.10.1) (Muscle-specific tyrosine-protein kinase receptor) (MuSK) (Muscle-specific kinase receptor) | Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle (PubMed:25537362). Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation (By similarity). {ECO:0000250, ECO:0000269|PubMed:25537362}. |
| O75116 | ROCK2 | S535 | Sugiyama | Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho kinase 2) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2) | Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation. {ECO:0000269|PubMed:10579722, ECO:0000269|PubMed:15699075, ECO:0000269|PubMed:16574662, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21147781}. |
| O43707 | ACTN4 | S763 | Sugiyama | Alpha-actinin-4 (Non-muscle alpha-actinin 4) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:22351778, ECO:0000269|PubMed:22689882, ECO:0000305|PubMed:9508771}. |
| P12814 | ACTN1 | S744 | Sugiyama | Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000269|PubMed:22689882}. |
| Q08378 | GOLGA3 | S497 | Sugiyama | Golgin subfamily A member 3 (Golgi complex-associated protein of 170 kDa) (GCP170) (Golgin-160) | Golgi auto-antigen; probably involved in maintaining Golgi structure. |
| O00327 | BMAL1 | S90 | GPS6 | Basic helix-loop-helix ARNT-like protein 1 (Aryl hydrocarbon receptor nuclear translocator-like protein 1) (Basic-helix-loop-helix-PAS protein MOP3) (Brain and muscle ARNT-like 1) (Class E basic helix-loop-helix protein 5) (bHLHe5) (Member of PAS protein 3) (PAS domain-containing protein 3) (bHLH-PAS protein JAP3) | Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. BMAL1 positively regulates myogenesis and negatively regulates adipogenesis via the transcriptional control of the genes of the canonical Wnt signaling pathway. Plays a role in normal pancreatic beta-cell function; regulates glucose-stimulated insulin secretion via the regulation of antioxidant genes NFE2L2/NRF2 and its targets SESN2, PRDX3, CCLC and CCLM. Negatively regulates the mTORC1 signaling pathway; regulates the expression of MTOR and DEPTOR. Controls diurnal oscillations of Ly6C inflammatory monocytes; rhythmic recruitment of the PRC2 complex imparts diurnal variation to chemokine expression that is necessary to sustain Ly6C monocyte rhythms. Regulates the expression of HSD3B2, STAR, PTGS2, CYP11A1, CYP19A1 and LHCGR in the ovary and also the genes involved in hair growth. Plays an important role in adult hippocampal neurogenesis by regulating the timely entry of neural stem/progenitor cells (NSPCs) into the cell cycle and the number of cell divisions that take place prior to cell-cycle exit. Regulates the circadian expression of CIART and KLF11. The CLOCK-BMAL1 heterodimer regulates the circadian expression of SERPINE1/PAI1, VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1, GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1, ATF4, MTA1, KLF10 and also genes implicated in glucose and lipid metabolism. Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors. The NPAS2-BMAL1 heterodimer positively regulates the expression of MAOA, F7 and LDHA and modulates the circadian rhythm of daytime contrast sensitivity by regulating the rhythmic expression of adenylate cyclase type 1 (ADCY1) in the retina. The preferred binding motif for the CLOCK-BMAL1 heterodimer is 5'-CACGTGA-3', which contains a flanking adenine nucleotide at the 3-prime end of the canonical 6-nucleotide E-box sequence (PubMed:23229515). CLOCK specifically binds to the half-site 5'-CAC-3', while BMAL1 binds to the half-site 5'-GTGA-3' (PubMed:23229515). The CLOCK-BMAL1 heterodimer also recognizes the non-canonical E-box motifs 5'-AACGTGA-3' and 5'-CATGTGA-3' (PubMed:23229515). Essential for the rhythmic interaction of CLOCK with ASS1 and plays a critical role in positively regulating CLOCK-mediated acetylation of ASS1 (PubMed:28985504). Plays a role in protecting against lethal sepsis by limiting the expression of immune checkpoint protein CD274 in macrophages in a PKM2-dependent manner (By similarity). Regulates the diurnal rhythms of skeletal muscle metabolism via transcriptional activation of genes promoting triglyceride synthesis (DGAT2) and metabolic efficiency (COQ10B) (By similarity). {ECO:0000250|UniProtKB:Q9WTL8, ECO:0000269|PubMed:11441146, ECO:0000269|PubMed:12738229, ECO:0000269|PubMed:18587630, ECO:0000269|PubMed:23785138, ECO:0000269|PubMed:23955654, ECO:0000269|PubMed:24005054, ECO:0000269|PubMed:28985504}.; FUNCTION: (Microbial infection) Regulates SARS coronavirus-2/SARS-CoV-2 entry and replication in lung epithelial cells probably through the post-transcriptional regulation of ACE2 and interferon-stimulated gene expression. {ECO:0000269|PubMed:34545347}. |
| P51114 | FXR1 | S60 | Sugiyama | RNA-binding protein FXR1 (FMR1 autosomal homolog 1) (hFXR1p) | mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for various processes, such as neurogenesis, muscle development and spermatogenesis (PubMed:17382880, PubMed:20417602, PubMed:30067974, PubMed:34731628, PubMed:35989368, PubMed:36306353). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:17382880, PubMed:34731628). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (By similarity). Required to activate translation of stored mRNAs during late spermatogenesis: acts by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules that recruit translation initiation factor EIF4G3 to activate translation of stored mRNAs in late spermatids (By similarity). Promotes translation of MYC transcripts by recruiting the eIF4F complex to the translation start site (PubMed:34731628). Acts as a negative regulator of inflammation in response to IL19 by promoting destabilization of pro-inflammatory transcripts (PubMed:30067974). Also acts as an inhibitor of inflammation by binding to TNF mRNA, decreasing TNF protein production (By similarity). Acts as a negative regulator of AMPA receptor GRIA2/GluA2 synthesis during long-lasting synaptic potentiation of hippocampal neurons by binding to GRIA2/GluA2 mRNA, thereby inhibiting its translation (By similarity). Regulates proliferation of adult neural stem cells by binding to CDKN1A mRNA and promoting its expression (By similarity). Acts as a regulator of sleep and synaptic homeostasis by regulating translation of transcripts in neurons (By similarity). Required for embryonic and postnatal development of muscle tissue by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules (PubMed:30770808). Involved in the nuclear pore complex localization to the nuclear envelope by preventing cytoplasmic aggregation of nucleoporins: acts by preventing ectopic phase separation of nucleoporins in the cytoplasm via a microtubule-dependent mechanism (PubMed:32706158). Plays a role in the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with PKP3 (PubMed:25225333). May also do the same for PKP2, PKP3 and DSP via its interaction with PKP1 (PubMed:25225333). Forms a cytoplasmic messenger ribonucleoprotein (mRNP) network by packaging long mRNAs, serving as a scaffold that recruits proteins and signaling molecules. This network facilitates signaling reactions by maintaining proximity between kinases and substrates, crucial for processes like actomyosin reorganization (PubMed:39106863). {ECO:0000250|UniProtKB:Q61584, ECO:0000269|PubMed:17382880, ECO:0000269|PubMed:20417602, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:30067974, ECO:0000269|PubMed:30770808, ECO:0000269|PubMed:32706158, ECO:0000269|PubMed:34731628, ECO:0000269|PubMed:35989368, ECO:0000269|PubMed:36306353, ECO:0000269|PubMed:39106863}. |
| Q13153 | PAK1 | S165 | iPTMNet | Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (Alpha-PAK) (p21-activated kinase 1) (PAK-1) (p65-PAK) | Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes (PubMed:10551809, PubMed:11896197, PubMed:12876277, PubMed:14585966, PubMed:15611088, PubMed:17726028, PubMed:17989089, PubMed:30290153, PubMed:17420447). Can directly phosphorylate BAD and protects cells against apoptosis (By similarity). Activated by interaction with CDC42 and RAC1 (PubMed:8805275, PubMed:9528787). Functions as a GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway (PubMed:8805275, PubMed:9528787). Phosphorylates and activates MAP2K1, and thereby mediates activation of downstream MAP kinases (By similarity). Involved in the reorganization of the actin cytoskeleton, actin stress fibers and of focal adhesion complexes (PubMed:9032240, PubMed:9395435). Phosphorylates the tubulin chaperone TBCB and thereby plays a role in the regulation of microtubule biogenesis and organization of the tubulin cytoskeleton (PubMed:15831477). Plays a role in the regulation of insulin secretion in response to elevated glucose levels (PubMed:22669945). Part of a ternary complex that contains PAK1, DVL1 and MUSK that is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By similarity). Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2 (PubMed:12624090). Phosphorylates MYL9/MLC2 (By similarity). Phosphorylates RAF1 at 'Ser-338' and 'Ser-339' resulting in: activation of RAF1, stimulation of RAF1 translocation to mitochondria, phosphorylation of BAD by RAF1, and RAF1 binding to BCL2 (PubMed:11733498). Phosphorylates SNAI1 at 'Ser-246' promoting its transcriptional repressor activity by increasing its accumulation in the nucleus (PubMed:15833848). In podocytes, promotes NR3C2 nuclear localization (By similarity). Required for atypical chemokine receptor ACKR2-induced phosphorylation of LIMK1 and cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:23633677). In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3, maybe through CFL1 phosphorylation and inactivation (By similarity). Plays a role in RUFY3-mediated facilitating gastric cancer cells migration and invasion (PubMed:25766321). In response to DNA damage, phosphorylates MORC2 which activates its ATPase activity and facilitates chromatin remodeling (PubMed:23260667). In neurons, plays a crucial role in regulating GABA(A) receptor synaptic stability and hence GABAergic inhibitory synaptic transmission through its role in F-actin stabilization (By similarity). In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity). Along with GIT1, positively regulates microtubule nucleation during interphase (PubMed:27012601). Phosphorylates FXR1, promoting its localization to stress granules and activity (PubMed:20417602). Phosphorylates ILK on 'Thr-173' and 'Ser-246', promoting nuclear export of ILK (PubMed:17420447). {ECO:0000250|UniProtKB:O88643, ECO:0000250|UniProtKB:P35465, ECO:0000269|PubMed:10551809, ECO:0000269|PubMed:11733498, ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:12624090, ECO:0000269|PubMed:12876277, ECO:0000269|PubMed:14585966, ECO:0000269|PubMed:15611088, ECO:0000269|PubMed:15831477, ECO:0000269|PubMed:15833848, ECO:0000269|PubMed:17420447, ECO:0000269|PubMed:17726028, ECO:0000269|PubMed:17989089, ECO:0000269|PubMed:20417602, ECO:0000269|PubMed:22669945, ECO:0000269|PubMed:23260667, ECO:0000269|PubMed:23633677, ECO:0000269|PubMed:25766321, ECO:0000269|PubMed:27012601, ECO:0000269|PubMed:30290153, ECO:0000269|PubMed:8805275, ECO:0000269|PubMed:9032240, ECO:0000269|PubMed:9395435, ECO:0000269|PubMed:9528787}. |
| Q13873 | BMPR2 | S233 | Sugiyama | Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Can also mediate signaling through the activation of the p38MAPK cascade (PubMed:12045205). Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6. Promotes signaling also by binding to activin A/INHBA (PubMed:24018044). {ECO:0000250|UniProtKB:O35607, ECO:0000269|PubMed:12045205, ECO:0000269|PubMed:24018044}. |
| P28340 | POLD1 | S1042 | Sugiyama | DNA polymerase delta catalytic subunit (EC 2.7.7.7) (3'-5' exodeoxyribonuclease) (EC 3.1.11.-) (DNA polymerase subunit delta p125) | As the catalytic component of the trimeric (Pol-delta3 complex) and tetrameric DNA polymerase delta complexes (Pol-delta4 complex), plays a crucial role in high fidelity genome replication, including in lagging strand synthesis, and repair (PubMed:16510448, PubMed:19074196, PubMed:20334433, PubMed:24022480, PubMed:24035200, PubMed:31449058). Exhibits both DNA polymerase and 3'- to 5'-exonuclease activities (PubMed:16510448, PubMed:19074196, PubMed:20334433, PubMed:24022480, PubMed:24035200). Requires the presence of accessory proteins POLD2, POLD3 and POLD4 for full activity. Depending upon the absence (Pol-delta3) or the presence of POLD4 (Pol-delta4), displays differences in catalytic activity. Most notably, expresses higher proofreading activity in the context of Pol-delta3 compared with that of Pol-delta4 (PubMed:19074196, PubMed:20334433). Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated (PubMed:24035200). Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation (PubMed:20227374). Under conditions of DNA replication stress, in the presence of POLD3 and POLD4, may catalyze the repair of broken replication forks through break-induced replication (BIR) (PubMed:24310611). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine, 8oxoG or abasic sites (PubMed:19074196, PubMed:24191025). {ECO:0000269|PubMed:16510448, ECO:0000269|PubMed:19074196, ECO:0000269|PubMed:20227374, ECO:0000269|PubMed:20334433, ECO:0000269|PubMed:24022480, ECO:0000269|PubMed:24035200, ECO:0000269|PubMed:24191025, ECO:0000269|PubMed:24310611, ECO:0000269|PubMed:31449058}. |
| Q8IU85 | CAMK1D | S65 | Sugiyama | Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase I delta) (CaM kinase ID) (CaM-KI delta) (CaMKI delta) (CaMKID) (CaMKI-like protein kinase) (CKLiK) | Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta. {ECO:0000269|PubMed:11050006, ECO:0000269|PubMed:15840691, ECO:0000269|PubMed:16324104, ECO:0000269|PubMed:17056143}. |
| P43246 | MSH2 | S540 | Sugiyama | DNA mismatch repair protein Msh2 (hMSH2) (MutS protein homolog 2) | Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. Recruits DNA helicase MCM9 to chromatin which unwinds the mismatch containing DNA strand (PubMed:26300262). ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. In melanocytes may modulate both UV-B-induced cell cycle regulation and apoptosis. {ECO:0000269|PubMed:10078208, ECO:0000269|PubMed:10660545, ECO:0000269|PubMed:15064730, ECO:0000269|PubMed:17611581, ECO:0000269|PubMed:21120944, ECO:0000269|PubMed:26300262, ECO:0000269|PubMed:9564049, ECO:0000269|PubMed:9822679, ECO:0000269|PubMed:9822680}. |
| O95376 | ARIH2 | S113 | Sugiyama | E3 ubiquitin-protein ligase ARIH2 (ARI-2) (Protein ariadne-2 homolog) (EC 2.3.2.31) (Triad1 protein) | E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 (PubMed:16118314, PubMed:17646546, PubMed:19340006, PubMed:24076655, PubMed:33268465, PubMed:34518685, PubMed:38418882). Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-5-RING ubiquitin ligase complex (ECS complex, also named CRL5 complex) and initiating ubiquitination of ECS substrates: associates with ECS complex and specifically mediates addition of the first ubiquitin on ECS targets (PubMed:33268465, PubMed:34518685, PubMed:38418882). The initial ubiquitin is then elongated (PubMed:33268465). E3 ubiquitin-protein ligase activity is activated upon binding to neddylated form of the cullin-5 (CUL5) component of the ECS complex (PubMed:24076655). Together with the ECS(ASB9) complex, catalyzes ubiquitination of CKB (PubMed:33268465). Promotes ubiquitination of DCUN1D1 (PubMed:30587576). Mediates 'Lys-6', 'Lys-48'- and 'Lys-63'-linked polyubiquitination (PubMed:16118314, PubMed:17646546, PubMed:19340006). May play a role in myelopoiesis (PubMed:19340006). {ECO:0000269|PubMed:16118314, ECO:0000269|PubMed:17646546, ECO:0000269|PubMed:19340006, ECO:0000269|PubMed:24076655, ECO:0000269|PubMed:30587576, ECO:0000269|PubMed:33268465, ECO:0000269|PubMed:34518685, ECO:0000269|PubMed:38418882}.; FUNCTION: (Microbial infection) Following infection by HIV-1 virus, acts together with a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex) hijacked by the HIV-1 Vif protein, to catalyze ubiquitination and degradation of APOBEC3F and APOBEC3G. {ECO:0000269|PubMed:31253590, ECO:0000269|PubMed:36754086}. |
| Q9NRG1 | PRTFDC1 | S169 | Sugiyama | Phosphoribosyltransferase domain-containing protein 1 | Has low, barely detectable phosphoribosyltransferase activity (in vitro). Binds GMP, IMP and alpha-D-5-phosphoribosyl 1-pyrophosphate (PRPP). Is not expected to contribute to purine metabolism or GMP salvage. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-6809371 | Formation of the cornified envelope | 1.265654e-14 | 13.898 |
| R-HSA-6805567 | Keratinization | 4.163692e-11 | 10.381 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 7.386972e-08 | 7.132 |
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 3.227734e-07 | 6.491 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 2.436745e-06 | 5.613 |
| R-HSA-373753 | Nephrin family interactions | 7.675047e-06 | 5.115 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 4.396424e-05 | 4.357 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 5.584290e-05 | 4.253 |
| R-HSA-1266738 | Developmental Biology | 1.218853e-04 | 3.914 |
| R-HSA-9012546 | Interleukin-18 signaling | 2.274164e-04 | 3.643 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 2.332079e-04 | 3.632 |
| R-HSA-75153 | Apoptotic execution phase | 2.831006e-04 | 3.548 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 4.321511e-04 | 3.364 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 5.380805e-04 | 3.269 |
| R-HSA-69166 | Removal of the Flap Intermediate | 9.446217e-04 | 3.025 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 9.654340e-04 | 3.015 |
| R-HSA-9734767 | Developmental Cell Lineages | 8.545921e-04 | 3.068 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 1.102536e-03 | 2.958 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 1.228449e-03 | 2.911 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 1.672956e-03 | 2.777 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 1.672956e-03 | 2.777 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 1.672956e-03 | 2.777 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 1.897135e-03 | 2.722 |
| R-HSA-5358508 | Mismatch Repair | 1.897135e-03 | 2.722 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 1.846930e-03 | 2.734 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 2.526651e-03 | 2.597 |
| R-HSA-69186 | Lagging Strand Synthesis | 2.678790e-03 | 2.572 |
| R-HSA-5693538 | Homology Directed Repair | 2.802737e-03 | 2.552 |
| R-HSA-9675135 | Diseases of DNA repair | 2.617142e-03 | 2.582 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 2.504342e-03 | 2.601 |
| R-HSA-194138 | Signaling by VEGF | 3.728706e-03 | 2.428 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 4.772222e-03 | 2.321 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 5.194299e-03 | 2.284 |
| R-HSA-180786 | Extension of Telomeres | 5.589995e-03 | 2.253 |
| R-HSA-446107 | Type I hemidesmosome assembly | 6.071331e-03 | 2.217 |
| R-HSA-390696 | Adrenoceptors | 6.071331e-03 | 2.217 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 6.104120e-03 | 2.214 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 7.176366e-03 | 2.144 |
| R-HSA-69190 | DNA strand elongation | 7.637179e-03 | 2.117 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 8.194084e-03 | 2.086 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 9.378039e-03 | 2.028 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 9.378039e-03 | 2.028 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 1.000548e-02 | 2.000 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 9.537849e-03 | 2.021 |
| R-HSA-1500931 | Cell-Cell communication | 9.177841e-03 | 2.037 |
| R-HSA-446652 | Interleukin-1 family signaling | 9.285647e-03 | 2.032 |
| R-HSA-5357801 | Programmed Cell Death | 9.813041e-03 | 2.008 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 1.098677e-02 | 1.959 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 1.079131e-02 | 1.967 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 1.203167e-02 | 1.920 |
| R-HSA-69109 | Leading Strand Synthesis | 1.241597e-02 | 1.906 |
| R-HSA-69091 | Polymerase switching | 1.241597e-02 | 1.906 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 1.079131e-02 | 1.967 |
| R-HSA-109581 | Apoptosis | 1.203199e-02 | 1.920 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 1.275552e-02 | 1.894 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 1.275552e-02 | 1.894 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 1.350380e-02 | 1.870 |
| R-HSA-73886 | Chromosome Maintenance | 1.415367e-02 | 1.849 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 1.358480e-02 | 1.867 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 1.427663e-02 | 1.845 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 1.427663e-02 | 1.845 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 1.809130e-02 | 1.743 |
| R-HSA-5632968 | Defective Mismatch Repair Associated With MSH6 | 2.065076e-02 | 1.685 |
| R-HSA-5632927 | Defective Mismatch Repair Associated With MSH3 | 2.065076e-02 | 1.685 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 2.067683e-02 | 1.685 |
| R-HSA-389356 | Co-stimulation by CD28 | 2.135231e-02 | 1.671 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 2.646553e-02 | 1.577 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 2.660233e-02 | 1.575 |
| R-HSA-157579 | Telomere Maintenance | 2.727608e-02 | 1.564 |
| R-HSA-5632928 | Defective Mismatch Repair Associated With MSH2 | 3.081661e-02 | 1.511 |
| R-HSA-190827 | Transport of connexins along the secretory pathway | 3.081661e-02 | 1.511 |
| R-HSA-190704 | Oligomerization of connexins into connexons | 3.081661e-02 | 1.511 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 3.282624e-02 | 1.484 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 3.971863e-02 | 1.401 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 3.625604e-02 | 1.441 |
| R-HSA-69239 | Synthesis of DNA | 3.688087e-02 | 1.433 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 3.971863e-02 | 1.401 |
| R-HSA-3000170 | Syndecan interactions | 3.736450e-02 | 1.428 |
| R-HSA-9707616 | Heme signaling | 3.757553e-02 | 1.425 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 3.556612e-02 | 1.449 |
| R-HSA-5633007 | Regulation of TP53 Activity | 3.975509e-02 | 1.401 |
| R-HSA-202403 | TCR signaling | 3.979791e-02 | 1.400 |
| R-HSA-3814836 | Glycogen storage disease type XV (GYG1) | 4.087756e-02 | 1.389 |
| R-HSA-3828062 | Glycogen storage disease type 0 (muscle GYS1) | 4.087756e-02 | 1.389 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 4.212756e-02 | 1.375 |
| R-HSA-191650 | Regulation of gap junction activity | 6.068904e-02 | 1.217 |
| R-HSA-9818035 | NFE2L2 regulating ER-stress associated genes | 6.068904e-02 | 1.217 |
| R-HSA-9818026 | NFE2L2 regulating inflammation associated genes | 7.044170e-02 | 1.152 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 4.458991e-02 | 1.351 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 5.494676e-02 | 1.260 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 5.765633e-02 | 1.239 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 5.765633e-02 | 1.239 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 6.321112e-02 | 1.199 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 6.321112e-02 | 1.199 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 6.605390e-02 | 1.180 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 6.893869e-02 | 1.162 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 7.186431e-02 | 1.143 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 6.890883e-02 | 1.162 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 6.893869e-02 | 1.162 |
| R-HSA-9931529 | Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK | 7.044170e-02 | 1.152 |
| R-HSA-9909396 | Circadian clock | 7.041148e-02 | 1.152 |
| R-HSA-5423599 | Diseases of Mismatch Repair (MMR) | 5.083468e-02 | 1.294 |
| R-HSA-5696400 | Dual Incision in GG-NER | 6.893869e-02 | 1.162 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 5.494676e-02 | 1.260 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 6.712793e-02 | 1.173 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 6.605390e-02 | 1.180 |
| R-HSA-9960525 | CASP5-mediated substrate cleavage | 5.083468e-02 | 1.294 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 4.710433e-02 | 1.327 |
| R-HSA-416482 | G alpha (12/13) signalling events | 6.191519e-02 | 1.208 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 6.191519e-02 | 1.208 |
| R-HSA-180746 | Nuclear import of Rev protein | 6.893869e-02 | 1.162 |
| R-HSA-114608 | Platelet degranulation | 6.250788e-02 | 1.204 |
| R-HSA-9960519 | CASP4-mediated substrate cleavage | 5.083468e-02 | 1.294 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 6.068904e-02 | 1.217 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 5.228405e-02 | 1.282 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 6.321112e-02 | 1.199 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 7.177653e-02 | 1.144 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 5.690118e-02 | 1.245 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 5.053287e-02 | 1.296 |
| R-HSA-8953854 | Metabolism of RNA | 6.501503e-02 | 1.187 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 7.071109e-02 | 1.151 |
| R-HSA-69481 | G2/M Checkpoints | 6.250788e-02 | 1.204 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 6.536856e-02 | 1.185 |
| R-HSA-69620 | Cell Cycle Checkpoints | 7.248298e-02 | 1.140 |
| R-HSA-9013694 | Signaling by NOTCH4 | 5.527481e-02 | 1.257 |
| R-HSA-162906 | HIV Infection | 4.601172e-02 | 1.337 |
| R-HSA-162909 | Host Interactions of HIV factors | 5.751511e-02 | 1.240 |
| R-HSA-422475 | Axon guidance | 7.391276e-02 | 1.131 |
| R-HSA-9675108 | Nervous system development | 5.234793e-02 | 1.281 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 4.899846e-02 | 1.310 |
| R-HSA-216083 | Integrin cell surface interactions | 6.191519e-02 | 1.208 |
| R-HSA-3371556 | Cellular response to heat stress | 5.391732e-02 | 1.268 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 5.690118e-02 | 1.245 |
| R-HSA-8853659 | RET signaling | 7.482963e-02 | 1.126 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 5.527481e-02 | 1.257 |
| R-HSA-9008059 | Interleukin-37 signaling | 5.494676e-02 | 1.260 |
| R-HSA-1474244 | Extracellular matrix organization | 7.627642e-02 | 1.118 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 7.783351e-02 | 1.109 |
| R-HSA-109582 | Hemostasis | 7.957371e-02 | 1.099 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 8.009369e-02 | 1.096 |
| R-HSA-427652 | Sodium-coupled phosphate cotransporters | 8.009369e-02 | 1.096 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 8.009369e-02 | 1.096 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 8.009369e-02 | 1.096 |
| R-HSA-5619070 | Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) | 8.964605e-02 | 1.047 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 9.909980e-02 | 1.004 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 9.909980e-02 | 1.004 |
| R-HSA-9010642 | ROBO receptors bind AKAP5 | 1.084560e-01 | 0.965 |
| R-HSA-3785653 | Myoclonic epilepsy of Lafora | 1.084560e-01 | 0.965 |
| R-HSA-196025 | Formation of annular gap junctions | 1.084560e-01 | 0.965 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 1.177155e-01 | 0.929 |
| R-HSA-190873 | Gap junction degradation | 1.177155e-01 | 0.929 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 1.359488e-01 | 0.867 |
| R-HSA-433692 | Proton-coupled monocarboxylate transport | 1.449245e-01 | 0.839 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 1.449245e-01 | 0.839 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 1.538075e-01 | 0.813 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 1.538075e-01 | 0.813 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 1.538075e-01 | 0.813 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 1.538075e-01 | 0.813 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 1.538075e-01 | 0.813 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 1.799098e-01 | 0.745 |
| R-HSA-8964616 | G beta:gamma signalling through CDC42 | 1.968651e-01 | 0.706 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 1.968651e-01 | 0.706 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 1.968651e-01 | 0.706 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 2.052116e-01 | 0.688 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 2.216468e-01 | 0.654 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 2.297373e-01 | 0.639 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.297373e-01 | 0.639 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 2.297373e-01 | 0.639 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.297373e-01 | 0.639 |
| R-HSA-210991 | Basigin interactions | 2.377442e-01 | 0.624 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 2.765542e-01 | 0.558 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 1.444317e-01 | 0.840 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 1.516187e-01 | 0.819 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 2.915225e-01 | 0.535 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 2.915225e-01 | 0.535 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 2.915225e-01 | 0.535 |
| R-HSA-167287 | HIV elongation arrest and recovery | 2.988907e-01 | 0.524 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 2.988907e-01 | 0.524 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 1.772813e-01 | 0.751 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 2.571147e-01 | 0.590 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 2.571147e-01 | 0.590 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 3.032504e-01 | 0.518 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 1.625988e-01 | 0.789 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 3.032504e-01 | 0.518 |
| R-HSA-9762292 | Regulation of CDH11 function | 1.268795e-01 | 0.897 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 2.915225e-01 | 0.535 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 2.073455e-01 | 0.683 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 2.216468e-01 | 0.654 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 1.538075e-01 | 0.813 |
| R-HSA-1236973 | Cross-presentation of particulate exogenous antigens (phagosomes) | 1.268795e-01 | 0.897 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 2.134719e-01 | 0.671 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 2.037354e-01 | 0.691 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 1.302904e-01 | 0.885 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 1.449245e-01 | 0.839 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 2.297373e-01 | 0.639 |
| R-HSA-525793 | Myogenesis | 2.840772e-01 | 0.547 |
| R-HSA-9764561 | Regulation of CDH1 Function | 1.480161e-01 | 0.830 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 2.532670e-01 | 0.596 |
| R-HSA-9927354 | Co-stimulation by ICOS | 1.084560e-01 | 0.965 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 1.177155e-01 | 0.929 |
| R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 1.177155e-01 | 0.929 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 1.449245e-01 | 0.839 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 1.449245e-01 | 0.839 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 1.625988e-01 | 0.789 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 1.799098e-01 | 0.745 |
| R-HSA-3322077 | Glycogen synthesis | 2.297373e-01 | 0.639 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 1.064269e-01 | 0.973 |
| R-HSA-350054 | Notch-HLH transcription pathway | 2.535105e-01 | 0.596 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 1.302904e-01 | 0.885 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 2.689527e-01 | 0.570 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 1.337946e-01 | 0.874 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 2.915225e-01 | 0.535 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 3.205415e-01 | 0.494 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 1.922342e-01 | 0.716 |
| R-HSA-201451 | Signaling by BMP | 2.915225e-01 | 0.535 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 2.591958e-01 | 0.586 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 1.538075e-01 | 0.813 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 1.959987e-01 | 0.708 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 1.084560e-01 | 0.965 |
| R-HSA-912631 | Regulation of signaling by CBL | 2.216468e-01 | 0.654 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 2.915225e-01 | 0.535 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 2.111436e-01 | 0.675 |
| R-HSA-448706 | Interleukin-1 processing | 1.177155e-01 | 0.929 |
| R-HSA-198203 | PI3K/AKT activation | 1.268795e-01 | 0.897 |
| R-HSA-3229121 | Glycogen storage diseases | 2.052116e-01 | 0.688 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 2.297373e-01 | 0.639 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 2.456683e-01 | 0.610 |
| R-HSA-2467813 | Separation of Sister Chromatids | 2.957906e-01 | 0.529 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 3.205415e-01 | 0.494 |
| R-HSA-9711123 | Cellular response to chemical stress | 1.839971e-01 | 0.735 |
| R-HSA-2564830 | Cytosolic iron-sulfur cluster assembly | 2.134719e-01 | 0.671 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 8.706553e-02 | 1.060 |
| R-HSA-9834899 | Specification of the neural plate border | 2.216468e-01 | 0.654 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 2.765542e-01 | 0.558 |
| R-HSA-194441 | Metabolism of non-coding RNA | 1.552385e-01 | 0.809 |
| R-HSA-191859 | snRNP Assembly | 1.552385e-01 | 0.809 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 1.625274e-01 | 0.789 |
| R-HSA-9824272 | Somitogenesis | 1.064269e-01 | 0.973 |
| R-HSA-445355 | Smooth Muscle Contraction | 1.337946e-01 | 0.874 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 2.765542e-01 | 0.558 |
| R-HSA-9766229 | Degradation of CDH1 | 1.199134e-01 | 0.921 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 8.964605e-02 | 1.047 |
| R-HSA-9673770 | Signaling by PDGFRA extracellular domain mutants | 1.799098e-01 | 0.745 |
| R-HSA-9673767 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 1.799098e-01 | 0.745 |
| R-HSA-6782135 | Dual incision in TC-NER | 1.516187e-01 | 0.819 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 2.915225e-01 | 0.535 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 3.061828e-01 | 0.514 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 2.704003e-01 | 0.568 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 1.968651e-01 | 0.706 |
| R-HSA-3928664 | Ephrin signaling | 2.134719e-01 | 0.671 |
| R-HSA-9758941 | Gastrulation | 2.536175e-01 | 0.596 |
| R-HSA-9842640 | Signaling by LTK in cancer | 8.964605e-02 | 1.047 |
| R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 1.177155e-01 | 0.929 |
| R-HSA-428540 | Activation of RAC1 | 1.449245e-01 | 0.839 |
| R-HSA-9796292 | Formation of axial mesoderm | 1.625988e-01 | 0.789 |
| R-HSA-418457 | cGMP effects | 1.712992e-01 | 0.766 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 1.884315e-01 | 0.725 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 8.706553e-02 | 1.060 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 8.706553e-02 | 1.060 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 9.021277e-02 | 1.045 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 2.915225e-01 | 0.535 |
| R-HSA-1234174 | Cellular response to hypoxia | 1.772813e-01 | 0.751 |
| R-HSA-399719 | Trafficking of AMPA receptors | 3.205415e-01 | 0.494 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 2.149487e-01 | 0.668 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 1.044220e-01 | 0.981 |
| R-HSA-844456 | The NLRP3 inflammasome | 2.216468e-01 | 0.654 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 2.342463e-01 | 0.630 |
| R-HSA-376176 | Signaling by ROBO receptors | 8.425695e-02 | 1.074 |
| R-HSA-73894 | DNA Repair | 1.045094e-01 | 0.981 |
| R-HSA-164944 | Nef and signal transduction | 8.964605e-02 | 1.047 |
| R-HSA-8851805 | MET activates RAS signaling | 1.538075e-01 | 0.813 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 2.052116e-01 | 0.688 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 8.087484e-02 | 1.092 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 2.134719e-01 | 0.671 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 1.097584e-01 | 0.960 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 2.840772e-01 | 0.547 |
| R-HSA-2129379 | Molecules associated with elastic fibres | 3.205415e-01 | 0.494 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 2.035550e-01 | 0.691 |
| R-HSA-69242 | S Phase | 9.700188e-02 | 1.013 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 2.494208e-01 | 0.603 |
| R-HSA-9837999 | Mitochondrial protein degradation | 2.955803e-01 | 0.529 |
| R-HSA-446728 | Cell junction organization | 2.019118e-01 | 0.695 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 2.535105e-01 | 0.596 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 1.097584e-01 | 0.960 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 1.097584e-01 | 0.960 |
| R-HSA-373755 | Semaphorin interactions | 1.698768e-01 | 0.770 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 1.625988e-01 | 0.789 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 8.395254e-02 | 1.076 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 2.456683e-01 | 0.610 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 2.612717e-01 | 0.583 |
| R-HSA-2160916 | Hyaluronan degradation | 2.765542e-01 | 0.558 |
| R-HSA-5689901 | Metalloprotease DUBs | 2.840772e-01 | 0.547 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 1.810025e-01 | 0.742 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 3.205415e-01 | 0.494 |
| R-HSA-68882 | Mitotic Anaphase | 2.335147e-01 | 0.632 |
| R-HSA-68886 | M Phase | 2.459137e-01 | 0.609 |
| R-HSA-1483249 | Inositol phosphate metabolism | 1.408034e-01 | 0.851 |
| R-HSA-9823730 | Formation of definitive endoderm | 2.297373e-01 | 0.639 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 1.031236e-01 | 0.987 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 1.480161e-01 | 0.830 |
| R-HSA-162587 | HIV Life Cycle | 1.118281e-01 | 0.951 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 2.357407e-01 | 0.628 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 2.456683e-01 | 0.610 |
| R-HSA-389948 | Co-inhibition by PD-1 | 1.965701e-01 | 0.706 |
| R-HSA-73893 | DNA Damage Bypass | 1.199134e-01 | 0.921 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 2.222692e-01 | 0.653 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.022095e-01 | 0.991 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 1.177155e-01 | 0.929 |
| R-HSA-3295583 | TRP channels | 2.840772e-01 | 0.547 |
| R-HSA-622312 | Inflammasomes | 2.988907e-01 | 0.524 |
| R-HSA-6784531 | tRNA processing in the nucleus | 1.661948e-01 | 0.779 |
| R-HSA-392154 | Nitric oxide stimulates guanylate cyclase | 3.061828e-01 | 0.514 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 1.153517e-01 | 0.938 |
| R-HSA-2682334 | EPH-Ephrin signaling | 2.878985e-01 | 0.541 |
| R-HSA-69306 | DNA Replication | 1.051185e-01 | 0.978 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 3.133995e-01 | 0.504 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 2.355402e-01 | 0.628 |
| R-HSA-1855167 | Synthesis of pyrophosphates in the cytosol | 2.612717e-01 | 0.583 |
| R-HSA-877300 | Interferon gamma signaling | 2.816590e-01 | 0.550 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 1.538075e-01 | 0.813 |
| R-HSA-418360 | Platelet calcium homeostasis | 3.061828e-01 | 0.514 |
| R-HSA-186763 | Downstream signal transduction | 3.205415e-01 | 0.494 |
| R-HSA-202424 | Downstream TCR signaling | 2.763604e-01 | 0.559 |
| R-HSA-5683057 | MAPK family signaling cascades | 1.866954e-01 | 0.729 |
| R-HSA-1640170 | Cell Cycle | 8.074766e-02 | 1.093 |
| R-HSA-9686114 | Non-canonical inflammasome activation | 1.712992e-01 | 0.766 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 2.377442e-01 | 0.624 |
| R-HSA-2424491 | DAP12 signaling | 3.133995e-01 | 0.504 |
| R-HSA-68875 | Mitotic Prophase | 1.654088e-01 | 0.781 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 1.386006e-01 | 0.858 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 2.377442e-01 | 0.624 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 3.133995e-01 | 0.504 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 3.070802e-01 | 0.513 |
| R-HSA-9012852 | Signaling by NOTCH3 | 1.408661e-01 | 0.851 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 2.216468e-01 | 0.654 |
| R-HSA-9830364 | Formation of the nephric duct | 2.765542e-01 | 0.558 |
| R-HSA-73884 | Base Excision Repair | 8.587438e-02 | 1.066 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 1.989646e-01 | 0.701 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 1.084560e-01 | 0.965 |
| R-HSA-9842663 | Signaling by LTK | 1.538075e-01 | 0.813 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 1.799098e-01 | 0.745 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 2.532670e-01 | 0.596 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 1.198403e-01 | 0.921 |
| R-HSA-186797 | Signaling by PDGF | 1.661948e-01 | 0.779 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.620593e-01 | 0.790 |
| R-HSA-180292 | GAB1 signalosome | 2.134719e-01 | 0.671 |
| R-HSA-445144 | Signal transduction by L1 | 2.297373e-01 | 0.639 |
| R-HSA-1227986 | Signaling by ERBB2 | 1.588750e-01 | 0.799 |
| R-HSA-3000178 | ECM proteoglycans | 1.997725e-01 | 0.699 |
| R-HSA-9706369 | Negative regulation of FLT3 | 1.884315e-01 | 0.725 |
| R-HSA-375280 | Amine ligand-binding receptors | 1.031236e-01 | 0.987 |
| R-HSA-9669938 | Signaling by KIT in disease | 2.535105e-01 | 0.596 |
| R-HSA-1266695 | Interleukin-7 signaling | 2.765542e-01 | 0.558 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 2.035550e-01 | 0.691 |
| R-HSA-373760 | L1CAM interactions | 1.554147e-01 | 0.809 |
| R-HSA-210993 | Tie2 Signaling | 2.134719e-01 | 0.671 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 9.021277e-02 | 1.045 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 3.133995e-01 | 0.504 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 2.535105e-01 | 0.596 |
| R-HSA-6783783 | Interleukin-10 signaling | 2.264003e-01 | 0.645 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 2.342463e-01 | 0.630 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 2.149487e-01 | 0.668 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 8.395254e-02 | 1.076 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 2.605444e-01 | 0.584 |
| R-HSA-9007101 | Rab regulation of trafficking | 1.578950e-01 | 0.802 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 2.612717e-01 | 0.583 |
| R-HSA-8964038 | LDL clearance | 2.535105e-01 | 0.596 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 2.612717e-01 | 0.583 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 2.571147e-01 | 0.590 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 2.187601e-01 | 0.660 |
| R-HSA-182971 | EGFR downregulation | 3.205415e-01 | 0.494 |
| R-HSA-5620971 | Pyroptosis | 2.988907e-01 | 0.524 |
| R-HSA-177929 | Signaling by EGFR | 1.444317e-01 | 0.840 |
| R-HSA-72306 | tRNA processing | 3.156446e-01 | 0.501 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 3.044477e-01 | 0.516 |
| R-HSA-5619102 | SLC transporter disorders | 3.042922e-01 | 0.517 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 2.377442e-01 | 0.624 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 3.133995e-01 | 0.504 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 3.213251e-01 | 0.493 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 3.223568e-01 | 0.492 |
| R-HSA-70171 | Glycolysis | 3.223568e-01 | 0.492 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 3.270067e-01 | 0.485 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 3.276097e-01 | 0.485 |
| R-HSA-4791275 | Signaling by WNT in cancer | 3.276097e-01 | 0.485 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 3.299649e-01 | 0.482 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 3.346049e-01 | 0.475 |
| R-HSA-397795 | G-protein beta:gamma signalling | 3.346049e-01 | 0.475 |
| R-HSA-354192 | Integrin signaling | 3.346049e-01 | 0.475 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 3.346049e-01 | 0.475 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 3.346049e-01 | 0.475 |
| R-HSA-9733709 | Cardiogenesis | 3.346049e-01 | 0.475 |
| R-HSA-168255 | Influenza Infection | 3.412078e-01 | 0.467 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 3.415276e-01 | 0.467 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 3.415276e-01 | 0.467 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 3.415276e-01 | 0.467 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 3.415276e-01 | 0.467 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 3.415276e-01 | 0.467 |
| R-HSA-189483 | Heme degradation | 3.415276e-01 | 0.467 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 3.415276e-01 | 0.467 |
| R-HSA-416476 | G alpha (q) signalling events | 3.443825e-01 | 0.463 |
| R-HSA-5696398 | Nucleotide Excision Repair | 3.451092e-01 | 0.462 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 3.483788e-01 | 0.458 |
| R-HSA-190861 | Gap junction assembly | 3.483788e-01 | 0.458 |
| R-HSA-2142845 | Hyaluronan metabolism | 3.483788e-01 | 0.458 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 3.483788e-01 | 0.458 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 3.483788e-01 | 0.458 |
| R-HSA-418346 | Platelet homeostasis | 3.488786e-01 | 0.457 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 3.525556e-01 | 0.453 |
| R-HSA-211000 | Gene Silencing by RNA | 3.526408e-01 | 0.453 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 3.551591e-01 | 0.450 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 3.551591e-01 | 0.450 |
| R-HSA-169911 | Regulation of Apoptosis | 3.551591e-01 | 0.450 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 3.560878e-01 | 0.448 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 3.563956e-01 | 0.448 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 3.563956e-01 | 0.448 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 3.563956e-01 | 0.448 |
| R-HSA-2672351 | Stimuli-sensing channels | 3.563956e-01 | 0.448 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 3.601427e-01 | 0.444 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 3.618693e-01 | 0.441 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 3.618693e-01 | 0.441 |
| R-HSA-111933 | Calmodulin induced events | 3.618693e-01 | 0.441 |
| R-HSA-111997 | CaM pathway | 3.618693e-01 | 0.441 |
| R-HSA-114604 | GPVI-mediated activation cascade | 3.618693e-01 | 0.441 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 3.618693e-01 | 0.441 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 3.685100e-01 | 0.434 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 3.685100e-01 | 0.434 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 3.685100e-01 | 0.434 |
| R-HSA-4641258 | Degradation of DVL | 3.685100e-01 | 0.434 |
| R-HSA-4641257 | Degradation of AXIN | 3.685100e-01 | 0.434 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 3.685100e-01 | 0.434 |
| R-HSA-1566948 | Elastic fibre formation | 3.750821e-01 | 0.426 |
| R-HSA-74217 | Purine salvage | 3.750821e-01 | 0.426 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 3.750821e-01 | 0.426 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 3.815861e-01 | 0.418 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 3.815861e-01 | 0.418 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 3.815861e-01 | 0.418 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 3.815861e-01 | 0.418 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 3.815861e-01 | 0.418 |
| R-HSA-69541 | Stabilization of p53 | 3.815861e-01 | 0.418 |
| R-HSA-201556 | Signaling by ALK | 3.815861e-01 | 0.418 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 3.815861e-01 | 0.418 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 3.815861e-01 | 0.418 |
| R-HSA-6798695 | Neutrophil degranulation | 3.816920e-01 | 0.418 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 3.868072e-01 | 0.413 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 3.880229e-01 | 0.411 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 3.880229e-01 | 0.411 |
| R-HSA-8982491 | Glycogen metabolism | 3.880229e-01 | 0.411 |
| R-HSA-167169 | HIV Transcription Elongation | 3.880229e-01 | 0.411 |
| R-HSA-3371568 | Attenuation phase | 3.880229e-01 | 0.411 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 3.880229e-01 | 0.411 |
| R-HSA-202433 | Generation of second messenger molecules | 3.880229e-01 | 0.411 |
| R-HSA-451927 | Interleukin-2 family signaling | 3.880229e-01 | 0.411 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 3.898141e-01 | 0.409 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 3.934815e-01 | 0.405 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 3.934815e-01 | 0.405 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 3.943930e-01 | 0.404 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 3.943930e-01 | 0.404 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 3.943930e-01 | 0.404 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 3.943930e-01 | 0.404 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 3.943930e-01 | 0.404 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 3.943930e-01 | 0.404 |
| R-HSA-9607240 | FLT3 Signaling | 3.943930e-01 | 0.404 |
| R-HSA-70326 | Glucose metabolism | 3.971391e-01 | 0.401 |
| R-HSA-5674135 | MAP2K and MAPK activation | 4.006973e-01 | 0.397 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 4.006973e-01 | 0.397 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 4.006973e-01 | 0.397 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 4.006973e-01 | 0.397 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 4.006973e-01 | 0.397 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 4.006973e-01 | 0.397 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 4.007866e-01 | 0.397 |
| R-HSA-2262752 | Cellular responses to stress | 4.009137e-01 | 0.397 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 4.069363e-01 | 0.390 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 4.069363e-01 | 0.390 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 4.069363e-01 | 0.390 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 4.069363e-01 | 0.390 |
| R-HSA-111996 | Ca-dependent events | 4.069363e-01 | 0.390 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 4.069363e-01 | 0.390 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 4.088022e-01 | 0.388 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 4.116669e-01 | 0.385 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 4.116669e-01 | 0.385 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 4.131107e-01 | 0.384 |
| R-HSA-1433557 | Signaling by SCF-KIT | 4.131107e-01 | 0.384 |
| R-HSA-8854214 | TBC/RABGAPs | 4.131107e-01 | 0.384 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 4.131107e-01 | 0.384 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 4.135861e-01 | 0.383 |
| R-HSA-913531 | Interferon Signaling | 4.135861e-01 | 0.383 |
| R-HSA-190828 | Gap junction trafficking | 4.192213e-01 | 0.378 |
| R-HSA-9907900 | Proteasome assembly | 4.192213e-01 | 0.378 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 4.192213e-01 | 0.378 |
| R-HSA-2172127 | DAP12 interactions | 4.192213e-01 | 0.378 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 4.192213e-01 | 0.378 |
| R-HSA-74160 | Gene expression (Transcription) | 4.200935e-01 | 0.377 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 4.252686e-01 | 0.371 |
| R-HSA-774815 | Nucleosome assembly | 4.252686e-01 | 0.371 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 4.252686e-01 | 0.371 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 4.252686e-01 | 0.371 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 4.252686e-01 | 0.371 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 4.252686e-01 | 0.371 |
| R-HSA-1489509 | DAG and IP3 signaling | 4.252686e-01 | 0.371 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 4.252686e-01 | 0.371 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 4.252686e-01 | 0.371 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 4.252686e-01 | 0.371 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 4.312532e-01 | 0.365 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 4.312532e-01 | 0.365 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 4.312532e-01 | 0.365 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 4.312532e-01 | 0.365 |
| R-HSA-6802949 | Signaling by RAS mutants | 4.312532e-01 | 0.365 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 4.312532e-01 | 0.365 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 4.312532e-01 | 0.365 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 4.371760e-01 | 0.359 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 4.371760e-01 | 0.359 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 4.391454e-01 | 0.357 |
| R-HSA-5620924 | Intraflagellar transport | 4.430374e-01 | 0.354 |
| R-HSA-157858 | Gap junction trafficking and regulation | 4.488382e-01 | 0.348 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 4.488382e-01 | 0.348 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 4.488382e-01 | 0.348 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 4.488382e-01 | 0.348 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 4.545788e-01 | 0.342 |
| R-HSA-109704 | PI3K Cascade | 4.545788e-01 | 0.342 |
| R-HSA-2162123 | Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | 4.545788e-01 | 0.342 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 4.576393e-01 | 0.339 |
| R-HSA-912446 | Meiotic recombination | 4.602601e-01 | 0.337 |
| R-HSA-3371571 | HSF1-dependent transactivation | 4.602601e-01 | 0.337 |
| R-HSA-9864848 | Complex IV assembly | 4.602601e-01 | 0.337 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 4.602601e-01 | 0.337 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 4.602601e-01 | 0.337 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 4.602601e-01 | 0.337 |
| R-HSA-72187 | mRNA 3'-end processing | 4.658825e-01 | 0.332 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 4.658825e-01 | 0.332 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 4.658825e-01 | 0.332 |
| R-HSA-68949 | Orc1 removal from chromatin | 4.658825e-01 | 0.332 |
| R-HSA-6794361 | Neurexins and neuroligins | 4.658825e-01 | 0.332 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 4.658825e-01 | 0.332 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 4.658825e-01 | 0.332 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 4.658825e-01 | 0.332 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 4.714467e-01 | 0.327 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 4.714467e-01 | 0.327 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 4.714467e-01 | 0.327 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 4.714467e-01 | 0.327 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 4.747691e-01 | 0.324 |
| R-HSA-72649 | Translation initiation complex formation | 4.769532e-01 | 0.322 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 4.769532e-01 | 0.322 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 4.815269e-01 | 0.317 |
| R-HSA-9948299 | Ribosome-associated quality control | 4.815297e-01 | 0.317 |
| R-HSA-418597 | G alpha (z) signalling events | 4.824028e-01 | 0.317 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 4.824028e-01 | 0.317 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 4.877959e-01 | 0.312 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 4.877959e-01 | 0.312 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 4.877959e-01 | 0.312 |
| R-HSA-112399 | IRS-mediated signalling | 4.931331e-01 | 0.307 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 4.984151e-01 | 0.302 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 5.014891e-01 | 0.300 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 5.031177e-01 | 0.298 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 5.036423e-01 | 0.298 |
| R-HSA-186712 | Regulation of beta-cell development | 5.036423e-01 | 0.298 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 5.036423e-01 | 0.298 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 5.088154e-01 | 0.293 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 5.088154e-01 | 0.293 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 5.088154e-01 | 0.293 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 5.088154e-01 | 0.293 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 5.088154e-01 | 0.293 |
| R-HSA-379724 | tRNA Aminoacylation | 5.088154e-01 | 0.293 |
| R-HSA-351202 | Metabolism of polyamines | 5.088154e-01 | 0.293 |
| R-HSA-157118 | Signaling by NOTCH | 5.108581e-01 | 0.292 |
| R-HSA-449147 | Signaling by Interleukins | 5.131499e-01 | 0.290 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 5.139348e-01 | 0.289 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 5.139348e-01 | 0.289 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 5.139348e-01 | 0.289 |
| R-HSA-112043 | PLC beta mediated events | 5.139348e-01 | 0.289 |
| R-HSA-8956321 | Nucleotide salvage | 5.139348e-01 | 0.289 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 5.190013e-01 | 0.285 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 5.190013e-01 | 0.285 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 5.190013e-01 | 0.285 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 5.190013e-01 | 0.285 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 5.235503e-01 | 0.281 |
| R-HSA-6799198 | Complex I biogenesis | 5.240152e-01 | 0.281 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 5.240152e-01 | 0.281 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 5.240152e-01 | 0.281 |
| R-HSA-73857 | RNA Polymerase II Transcription | 5.260066e-01 | 0.279 |
| R-HSA-2428924 | IGF1R signaling cascade | 5.289772e-01 | 0.277 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 5.289772e-01 | 0.277 |
| R-HSA-74751 | Insulin receptor signalling cascade | 5.289772e-01 | 0.277 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 5.304927e-01 | 0.275 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 5.304927e-01 | 0.275 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 5.338877e-01 | 0.273 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 5.367817e-01 | 0.270 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 5.386278e-01 | 0.269 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 5.387474e-01 | 0.269 |
| R-HSA-1989781 | PPARA activates gene expression | 5.399045e-01 | 0.268 |
| R-HSA-112040 | G-protein mediated events | 5.435567e-01 | 0.265 |
| R-HSA-9830369 | Kidney development | 5.435567e-01 | 0.265 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 5.435567e-01 | 0.265 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 5.461069e-01 | 0.263 |
| R-HSA-9610379 | HCMV Late Events | 5.461069e-01 | 0.263 |
| R-HSA-167172 | Transcription of the HIV genome | 5.483161e-01 | 0.261 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 5.483161e-01 | 0.261 |
| R-HSA-5218859 | Regulated Necrosis | 5.483161e-01 | 0.261 |
| R-HSA-9711097 | Cellular response to starvation | 5.491863e-01 | 0.260 |
| R-HSA-168249 | Innate Immune System | 5.494999e-01 | 0.260 |
| R-HSA-199991 | Membrane Trafficking | 5.503537e-01 | 0.259 |
| R-HSA-9006936 | Signaling by TGFB family members | 5.553013e-01 | 0.255 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 5.576875e-01 | 0.254 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 5.576875e-01 | 0.254 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 5.576875e-01 | 0.254 |
| R-HSA-9679506 | SARS-CoV Infections | 5.587696e-01 | 0.253 |
| R-HSA-1280218 | Adaptive Immune System | 5.603514e-01 | 0.252 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 5.623005e-01 | 0.250 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 5.623005e-01 | 0.250 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 5.623005e-01 | 0.250 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 5.623005e-01 | 0.250 |
| R-HSA-5632684 | Hedgehog 'on' state | 5.623005e-01 | 0.250 |
| R-HSA-189445 | Metabolism of porphyrins | 5.623005e-01 | 0.250 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 5.668656e-01 | 0.247 |
| R-HSA-2408522 | Selenoamino acid metabolism | 5.673558e-01 | 0.246 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 5.713834e-01 | 0.243 |
| R-HSA-4086398 | Ca2+ pathway | 5.713834e-01 | 0.243 |
| R-HSA-5663084 | Diseases of carbohydrate metabolism | 5.713834e-01 | 0.243 |
| R-HSA-9749641 | Aspirin ADME | 5.713834e-01 | 0.243 |
| R-HSA-8852135 | Protein ubiquitination | 5.802789e-01 | 0.236 |
| R-HSA-212436 | Generic Transcription Pathway | 5.804902e-01 | 0.236 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 5.846576e-01 | 0.233 |
| R-HSA-1980143 | Signaling by NOTCH1 | 5.846576e-01 | 0.233 |
| R-HSA-5689603 | UCH proteinases | 5.846576e-01 | 0.233 |
| R-HSA-73864 | RNA Polymerase I Transcription | 5.932793e-01 | 0.227 |
| R-HSA-9955298 | SLC-mediated transport of organic anions | 5.932793e-01 | 0.227 |
| R-HSA-5619084 | ABC transporter disorders | 5.932793e-01 | 0.227 |
| R-HSA-4086400 | PCP/CE pathway | 5.932793e-01 | 0.227 |
| R-HSA-162582 | Signal Transduction | 5.942823e-01 | 0.226 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 5.964598e-01 | 0.224 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 5.964598e-01 | 0.224 |
| R-HSA-9659379 | Sensory processing of sound | 5.975232e-01 | 0.224 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 5.975232e-01 | 0.224 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 6.017230e-01 | 0.221 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 6.017230e-01 | 0.221 |
| R-HSA-6806834 | Signaling by MET | 6.017230e-01 | 0.221 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 6.021029e-01 | 0.220 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 6.058793e-01 | 0.218 |
| R-HSA-611105 | Respiratory electron transport | 6.104565e-01 | 0.214 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 6.140630e-01 | 0.212 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 6.180912e-01 | 0.209 |
| R-HSA-1500620 | Meiosis | 6.220777e-01 | 0.206 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 6.220777e-01 | 0.206 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 6.260228e-01 | 0.203 |
| R-HSA-70268 | Pyruvate metabolism | 6.337906e-01 | 0.198 |
| R-HSA-156902 | Peptide chain elongation | 6.376141e-01 | 0.195 |
| R-HSA-983712 | Ion channel transport | 6.399485e-01 | 0.194 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 6.403898e-01 | 0.194 |
| R-HSA-1236974 | ER-Phagosome pathway | 6.413979e-01 | 0.193 |
| R-HSA-5617833 | Cilium Assembly | 6.425413e-01 | 0.192 |
| R-HSA-195721 | Signaling by WNT | 6.467255e-01 | 0.189 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 6.476830e-01 | 0.189 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 6.488482e-01 | 0.188 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 6.488482e-01 | 0.188 |
| R-HSA-68877 | Mitotic Prometaphase | 6.502320e-01 | 0.187 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 6.525155e-01 | 0.185 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 6.527664e-01 | 0.185 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 6.561446e-01 | 0.183 |
| R-HSA-74752 | Signaling by Insulin receptor | 6.561446e-01 | 0.183 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 6.561446e-01 | 0.183 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 6.577917e-01 | 0.182 |
| R-HSA-9609690 | HCMV Early Events | 6.577917e-01 | 0.182 |
| R-HSA-9824446 | Viral Infection Pathways | 6.580856e-01 | 0.182 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 6.597361e-01 | 0.181 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 6.632903e-01 | 0.178 |
| R-HSA-1474290 | Collagen formation | 6.632903e-01 | 0.178 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 6.668076e-01 | 0.176 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 6.668076e-01 | 0.176 |
| R-HSA-72764 | Eukaryotic Translation Termination | 6.702883e-01 | 0.174 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 6.737329e-01 | 0.172 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 6.737329e-01 | 0.172 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 6.737329e-01 | 0.172 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 6.771418e-01 | 0.169 |
| R-HSA-72172 | mRNA Splicing | 6.796921e-01 | 0.168 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 6.805152e-01 | 0.167 |
| R-HSA-422356 | Regulation of insulin secretion | 6.805152e-01 | 0.167 |
| R-HSA-9614085 | FOXO-mediated transcription | 6.838536e-01 | 0.165 |
| R-HSA-3214847 | HATs acetylate histones | 6.838536e-01 | 0.165 |
| R-HSA-5610787 | Hedgehog 'off' state | 6.871573e-01 | 0.163 |
| R-HSA-382556 | ABC-family proteins mediated transport | 6.871573e-01 | 0.163 |
| R-HSA-2408557 | Selenocysteine synthesis | 6.904267e-01 | 0.161 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 6.904267e-01 | 0.161 |
| R-HSA-9020702 | Interleukin-1 signaling | 6.904267e-01 | 0.161 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 6.907790e-01 | 0.161 |
| R-HSA-72766 | Translation | 6.932812e-01 | 0.159 |
| R-HSA-1483255 | PI Metabolism | 6.936621e-01 | 0.159 |
| R-HSA-192823 | Viral mRNA Translation | 6.968639e-01 | 0.157 |
| R-HSA-397014 | Muscle contraction | 6.981937e-01 | 0.156 |
| R-HSA-168256 | Immune System | 6.990120e-01 | 0.156 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 7.000325e-01 | 0.155 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 7.000325e-01 | 0.155 |
| R-HSA-111885 | Opioid Signalling | 7.000325e-01 | 0.155 |
| R-HSA-9833110 | RSV-host interactions | 7.031681e-01 | 0.153 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 7.031681e-01 | 0.153 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 7.031681e-01 | 0.153 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 7.093419e-01 | 0.149 |
| R-HSA-418990 | Adherens junctions interactions | 7.114860e-01 | 0.148 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 7.123808e-01 | 0.147 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 7.123808e-01 | 0.147 |
| R-HSA-9700206 | Signaling by ALK in cancer | 7.123808e-01 | 0.147 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 7.183641e-01 | 0.144 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 7.271079e-01 | 0.138 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 7.271079e-01 | 0.138 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 7.271079e-01 | 0.138 |
| R-HSA-388396 | GPCR downstream signalling | 7.277826e-01 | 0.138 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 7.284484e-01 | 0.138 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 7.288917e-01 | 0.137 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 7.299620e-01 | 0.137 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 7.343664e-01 | 0.134 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 7.355817e-01 | 0.133 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 7.383478e-01 | 0.132 |
| R-HSA-3247509 | Chromatin modifying enzymes | 7.445640e-01 | 0.128 |
| R-HSA-1592230 | Mitochondrial biogenesis | 7.464746e-01 | 0.127 |
| R-HSA-2980736 | Peptide hormone metabolism | 7.464746e-01 | 0.127 |
| R-HSA-8939211 | ESR-mediated signaling | 7.503943e-01 | 0.125 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 7.517526e-01 | 0.124 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 7.619831e-01 | 0.118 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 7.619831e-01 | 0.118 |
| R-HSA-5653656 | Vesicle-mediated transport | 7.664625e-01 | 0.116 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 7.693799e-01 | 0.114 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 7.693799e-01 | 0.114 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 7.693799e-01 | 0.114 |
| R-HSA-69206 | G1/S Transition | 7.693799e-01 | 0.114 |
| R-HSA-4839726 | Chromatin organization | 7.725894e-01 | 0.112 |
| R-HSA-9609646 | HCMV Infection | 7.743596e-01 | 0.111 |
| R-HSA-421270 | Cell-cell junction organization | 7.761178e-01 | 0.110 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 7.765482e-01 | 0.110 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 7.812036e-01 | 0.107 |
| R-HSA-5688426 | Deubiquitination | 7.830321e-01 | 0.106 |
| R-HSA-1474165 | Reproduction | 7.834950e-01 | 0.106 |
| R-HSA-9843745 | Adipogenesis | 7.857625e-01 | 0.105 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 7.988805e-01 | 0.098 |
| R-HSA-163685 | Integration of energy metabolism | 7.988805e-01 | 0.098 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 8.009878e-01 | 0.096 |
| R-HSA-5358351 | Signaling by Hedgehog | 8.030732e-01 | 0.095 |
| R-HSA-6807070 | PTEN Regulation | 8.051368e-01 | 0.094 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 8.091998e-01 | 0.092 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 8.139186e-01 | 0.089 |
| R-HSA-372790 | Signaling by GPCR | 8.150150e-01 | 0.089 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 8.170750e-01 | 0.088 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 8.208905e-01 | 0.086 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 8.227685e-01 | 0.085 |
| R-HSA-9658195 | Leishmania infection | 8.235815e-01 | 0.084 |
| R-HSA-9824443 | Parasitic Infection Pathways | 8.235815e-01 | 0.084 |
| R-HSA-166520 | Signaling by NTRKs | 8.246269e-01 | 0.084 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 8.282858e-01 | 0.082 |
| R-HSA-9679191 | Potential therapeutics for SARS | 8.282858e-01 | 0.082 |
| R-HSA-2142753 | Arachidonate metabolism | 8.318688e-01 | 0.080 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 8.353775e-01 | 0.078 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 8.421780e-01 | 0.075 |
| R-HSA-1643685 | Disease | 8.576411e-01 | 0.067 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 8.624089e-01 | 0.064 |
| R-HSA-5663205 | Infectious disease | 8.644198e-01 | 0.063 |
| R-HSA-5689880 | Ub-specific processing proteases | 8.666986e-01 | 0.062 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 8.694842e-01 | 0.061 |
| R-HSA-69275 | G2/M Transition | 8.838023e-01 | 0.054 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 8.862325e-01 | 0.052 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 8.862325e-01 | 0.052 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 8.920892e-01 | 0.050 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 8.997883e-01 | 0.046 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 9.018860e-01 | 0.045 |
| R-HSA-382551 | Transport of small molecules | 9.033129e-01 | 0.044 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 9.107372e-01 | 0.041 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 9.126667e-01 | 0.040 |
| R-HSA-9748784 | Drug ADME | 9.180419e-01 | 0.037 |
| R-HSA-8951664 | Neddylation | 9.206049e-01 | 0.036 |
| R-HSA-72312 | rRNA processing | 9.293392e-01 | 0.032 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.322447e-01 | 0.030 |
| R-HSA-15869 | Metabolism of nucleotides | 9.322726e-01 | 0.030 |
| R-HSA-418594 | G alpha (i) signalling events | 9.395050e-01 | 0.027 |
| R-HSA-1483257 | Phospholipid metabolism | 9.638078e-01 | 0.016 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.645638e-01 | 0.016 |
| R-HSA-112316 | Neuronal System | 9.647861e-01 | 0.016 |
| R-HSA-112315 | Transmission across Chemical Synapses | 9.731402e-01 | 0.012 |
| R-HSA-8957322 | Metabolism of steroids | 9.734250e-01 | 0.012 |
| R-HSA-597592 | Post-translational protein modification | 9.846798e-01 | 0.007 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.870099e-01 | 0.006 |
| R-HSA-392499 | Metabolism of proteins | 9.872511e-01 | 0.006 |
| R-HSA-500792 | GPCR ligand binding | 9.884103e-01 | 0.005 |
| R-HSA-8978868 | Fatty acid metabolism | 9.891725e-01 | 0.005 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.907812e-01 | 0.004 |
| R-HSA-5668914 | Diseases of metabolism | 9.912627e-01 | 0.004 |
| R-HSA-556833 | Metabolism of lipids | 9.999320e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999782e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999988e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
AMPKA2 |
0.781 | 0.268 | -3 | 0.341 |
AMPKA1 |
0.780 | 0.276 | -3 | 0.320 |
PKN3 |
0.779 | 0.155 | -3 | 0.237 |
NUAK1 |
0.779 | 0.220 | -3 | 0.346 |
NUAK2 |
0.779 | 0.235 | -3 | 0.327 |
SIK |
0.777 | 0.201 | -3 | 0.328 |
PRKD2 |
0.776 | 0.173 | -3 | 0.340 |
MELK |
0.776 | 0.251 | -3 | 0.342 |
LATS2 |
0.775 | 0.166 | -5 | 0.749 |
RSK2 |
0.775 | 0.098 | -3 | 0.264 |
NDR2 |
0.775 | 0.130 | -3 | 0.284 |
PAK6 |
0.774 | 0.278 | -2 | 0.718 |
TSSK1 |
0.774 | 0.250 | -3 | 0.324 |
TBK1 |
0.773 | 0.087 | 1 | 0.825 |
MAPKAPK3 |
0.773 | 0.141 | -3 | 0.292 |
MAPKAPK2 |
0.773 | 0.114 | -3 | 0.285 |
CAMK4 |
0.772 | 0.255 | -3 | 0.344 |
PIM3 |
0.771 | 0.092 | -3 | 0.246 |
MARK4 |
0.771 | 0.149 | 4 | 0.844 |
BRSK1 |
0.771 | 0.182 | -3 | 0.317 |
RSK3 |
0.771 | 0.067 | -3 | 0.242 |
P90RSK |
0.770 | 0.054 | -3 | 0.227 |
CLK3 |
0.770 | 0.163 | 1 | 0.767 |
CAMK1B |
0.770 | 0.158 | -3 | 0.261 |
PKACG |
0.770 | 0.138 | -2 | 0.763 |
QSK |
0.769 | 0.173 | 4 | 0.828 |
COT |
0.769 | 0.018 | 2 | 0.825 |
WNK1 |
0.769 | 0.224 | -2 | 0.861 |
PIM1 |
0.769 | 0.125 | -3 | 0.279 |
PKN2 |
0.769 | 0.199 | -3 | 0.299 |
PRKD1 |
0.769 | 0.068 | -3 | 0.232 |
BRSK2 |
0.768 | 0.206 | -3 | 0.338 |
IKKE |
0.768 | 0.041 | 1 | 0.827 |
CAMK2D |
0.768 | 0.138 | -3 | 0.249 |
RAF1 |
0.768 | 0.111 | 1 | 0.847 |
NDR1 |
0.768 | 0.133 | -3 | 0.297 |
SGK3 |
0.767 | 0.161 | -3 | 0.291 |
PRKX |
0.767 | 0.185 | -3 | 0.393 |
IKKB |
0.766 | 0.007 | -2 | 0.790 |
PKCD |
0.766 | 0.154 | 2 | 0.757 |
CLK1 |
0.766 | 0.149 | -3 | 0.342 |
P70S6KB |
0.766 | 0.119 | -3 | 0.289 |
NIM1 |
0.766 | 0.077 | 3 | 0.695 |
MST4 |
0.765 | 0.174 | 2 | 0.784 |
PHKG2 |
0.765 | 0.291 | -3 | 0.409 |
PRKD3 |
0.764 | 0.109 | -3 | 0.304 |
MNK2 |
0.764 | 0.218 | -2 | 0.798 |
MNK1 |
0.764 | 0.264 | -2 | 0.811 |
PDHK1 |
0.764 | 0.009 | 1 | 0.862 |
ULK2 |
0.764 | -0.042 | 2 | 0.796 |
RSK4 |
0.764 | 0.089 | -3 | 0.268 |
CDC7 |
0.764 | -0.013 | 1 | 0.750 |
QIK |
0.764 | 0.170 | -3 | 0.284 |
PKACB |
0.764 | 0.145 | -2 | 0.682 |
WNK3 |
0.763 | 0.114 | 1 | 0.814 |
SRPK2 |
0.763 | 0.017 | -3 | 0.185 |
CHK1 |
0.763 | 0.226 | -3 | 0.320 |
SKMLCK |
0.763 | 0.162 | -2 | 0.836 |
CAMK2G |
0.763 | 0.038 | 2 | 0.787 |
MARK1 |
0.763 | 0.189 | 4 | 0.812 |
PRPK |
0.762 | -0.031 | -1 | 0.785 |
PHKG1 |
0.762 | 0.188 | -3 | 0.321 |
HUNK |
0.762 | 0.032 | 2 | 0.803 |
TSSK2 |
0.762 | 0.157 | -5 | 0.784 |
DCAMKL1 |
0.762 | 0.281 | -3 | 0.392 |
MTOR |
0.762 | -0.017 | 1 | 0.812 |
MARK2 |
0.762 | 0.155 | 4 | 0.759 |
CAMK2B |
0.762 | 0.158 | 2 | 0.748 |
MARK3 |
0.762 | 0.167 | 4 | 0.795 |
NIK |
0.762 | 0.226 | -3 | 0.261 |
PDHK4 |
0.762 | -0.063 | 1 | 0.840 |
AKT2 |
0.762 | 0.097 | -3 | 0.284 |
PKACA |
0.762 | 0.137 | -2 | 0.632 |
BCKDK |
0.761 | 0.025 | -1 | 0.752 |
CAMK1D |
0.761 | 0.167 | -3 | 0.351 |
CDKL1 |
0.761 | -0.010 | -3 | 0.171 |
AKT1 |
0.761 | 0.137 | -3 | 0.319 |
DCAMKL2 |
0.760 | 0.274 | -3 | 0.400 |
SRPK1 |
0.760 | 0.019 | -3 | 0.193 |
PKG2 |
0.760 | 0.145 | -2 | 0.690 |
IKKA |
0.759 | 0.030 | -2 | 0.767 |
ULK1 |
0.759 | -0.059 | -3 | 0.104 |
PAK3 |
0.759 | 0.131 | -2 | 0.783 |
CLK4 |
0.759 | 0.105 | -3 | 0.299 |
CAMK2A |
0.759 | 0.141 | 2 | 0.750 |
NLK |
0.758 | 0.009 | 1 | 0.805 |
LATS1 |
0.757 | 0.150 | -3 | 0.265 |
GCN2 |
0.757 | -0.109 | 2 | 0.789 |
MSK2 |
0.757 | 0.002 | -3 | 0.180 |
PAK1 |
0.757 | 0.130 | -2 | 0.771 |
CAMLCK |
0.757 | 0.065 | -2 | 0.846 |
AURC |
0.756 | 0.117 | -2 | 0.659 |
DSTYK |
0.755 | -0.084 | 2 | 0.826 |
DAPK2 |
0.755 | 0.091 | -3 | 0.239 |
PIM2 |
0.754 | 0.096 | -3 | 0.282 |
RIPK3 |
0.754 | 0.022 | 3 | 0.617 |
ATR |
0.754 | -0.019 | 1 | 0.773 |
TGFBR2 |
0.753 | -0.009 | -2 | 0.795 |
MSK1 |
0.753 | 0.036 | -3 | 0.209 |
CDKL5 |
0.753 | -0.021 | -3 | 0.170 |
MOS |
0.753 | -0.026 | 1 | 0.771 |
SNRK |
0.752 | 0.091 | 2 | 0.715 |
MYLK4 |
0.752 | 0.093 | -2 | 0.768 |
BMPR2 |
0.752 | -0.142 | -2 | 0.873 |
SGK1 |
0.752 | 0.071 | -3 | 0.237 |
ICK |
0.752 | 0.012 | -3 | 0.194 |
SSTK |
0.751 | 0.194 | 4 | 0.819 |
PKCH |
0.751 | 0.112 | 2 | 0.713 |
AURB |
0.751 | 0.098 | -2 | 0.660 |
PKN1 |
0.751 | 0.124 | -3 | 0.288 |
MASTL |
0.750 | -0.041 | -2 | 0.839 |
GRK6 |
0.750 | -0.007 | 1 | 0.775 |
NEK7 |
0.750 | -0.113 | -3 | 0.107 |
P70S6K |
0.750 | 0.050 | -3 | 0.239 |
PAK5 |
0.750 | 0.175 | -2 | 0.654 |
PKCG |
0.750 | 0.104 | 2 | 0.699 |
CAMK1A |
0.750 | 0.120 | -3 | 0.322 |
FAM20C |
0.750 | 0.070 | 2 | 0.652 |
CHK2 |
0.749 | 0.104 | -3 | 0.315 |
PKCA |
0.749 | 0.081 | 2 | 0.697 |
NEK6 |
0.749 | -0.076 | -2 | 0.835 |
PKCB |
0.748 | 0.094 | 2 | 0.698 |
CAMK1G |
0.748 | 0.073 | -3 | 0.280 |
AKT3 |
0.748 | 0.065 | -3 | 0.247 |
PAK2 |
0.747 | 0.073 | -2 | 0.766 |
ERK5 |
0.747 | -0.045 | 1 | 0.720 |
HIPK4 |
0.747 | -0.019 | 1 | 0.722 |
CLK2 |
0.747 | 0.098 | -3 | 0.298 |
SBK |
0.747 | 0.068 | -3 | 0.277 |
GRK5 |
0.747 | -0.092 | -3 | 0.134 |
GRK1 |
0.747 | -0.013 | -2 | 0.807 |
SRPK3 |
0.747 | -0.019 | -3 | 0.156 |
NEK9 |
0.746 | -0.072 | 2 | 0.811 |
PKCZ |
0.746 | 0.099 | 2 | 0.750 |
DNAPK |
0.746 | 0.040 | 1 | 0.770 |
RIPK1 |
0.745 | -0.034 | 1 | 0.790 |
NEK2 |
0.745 | -0.026 | 2 | 0.783 |
IRE2 |
0.744 | 0.014 | 2 | 0.767 |
PLK4 |
0.744 | 0.055 | 2 | 0.678 |
MLK1 |
0.744 | -0.097 | 2 | 0.786 |
PLK1 |
0.744 | 0.004 | -2 | 0.811 |
PAK4 |
0.744 | 0.145 | -2 | 0.651 |
AURA |
0.744 | 0.056 | -2 | 0.623 |
PKCT |
0.743 | 0.092 | 2 | 0.716 |
ANKRD3 |
0.743 | -0.035 | 1 | 0.848 |
CHAK2 |
0.743 | -0.031 | -1 | 0.766 |
PLK3 |
0.743 | 0.006 | 2 | 0.754 |
IRE1 |
0.742 | -0.012 | 1 | 0.716 |
ATM |
0.742 | -0.030 | 1 | 0.730 |
GRK4 |
0.741 | -0.095 | -2 | 0.803 |
KIS |
0.741 | -0.024 | 1 | 0.683 |
MAPKAPK5 |
0.741 | -0.063 | -3 | 0.162 |
TGFBR1 |
0.740 | 0.010 | -2 | 0.816 |
BRAF |
0.740 | 0.100 | -4 | 0.809 |
MRCKA |
0.740 | 0.156 | -3 | 0.336 |
DLK |
0.740 | -0.068 | 1 | 0.802 |
WNK4 |
0.739 | 0.081 | -2 | 0.851 |
MLK2 |
0.739 | -0.051 | 2 | 0.787 |
MRCKB |
0.739 | 0.142 | -3 | 0.330 |
DYRK1A |
0.739 | 0.002 | 1 | 0.720 |
TTBK2 |
0.738 | -0.088 | 2 | 0.691 |
ALK4 |
0.738 | -0.005 | -2 | 0.842 |
PKG1 |
0.738 | 0.099 | -2 | 0.624 |
CDK8 |
0.738 | -0.021 | 1 | 0.651 |
MEK1 |
0.738 | -0.018 | 2 | 0.831 |
YSK4 |
0.737 | -0.016 | 1 | 0.804 |
SMMLCK |
0.736 | 0.060 | -3 | 0.244 |
CDK7 |
0.736 | 0.010 | 1 | 0.651 |
PKCI |
0.736 | 0.084 | 2 | 0.721 |
DYRK2 |
0.736 | -0.008 | 1 | 0.649 |
GRK7 |
0.735 | 0.041 | 1 | 0.718 |
IRAK4 |
0.735 | 0.056 | 1 | 0.762 |
CHAK1 |
0.734 | -0.028 | 2 | 0.757 |
PKCE |
0.734 | 0.105 | 2 | 0.691 |
CDK5 |
0.734 | 0.021 | 1 | 0.653 |
JNK2 |
0.733 | 0.034 | 1 | 0.623 |
BMPR1B |
0.733 | -0.001 | 1 | 0.675 |
CDK19 |
0.733 | -0.018 | 1 | 0.616 |
PKR |
0.733 | -0.024 | 1 | 0.776 |
HIPK1 |
0.732 | 0.022 | 1 | 0.670 |
CK1G1 |
0.732 | -0.087 | -3 | 0.060 |
ROCK2 |
0.732 | 0.167 | -3 | 0.329 |
SMG1 |
0.732 | -0.060 | 1 | 0.728 |
DMPK1 |
0.732 | 0.200 | -3 | 0.378 |
TAO3 |
0.731 | 0.183 | 1 | 0.802 |
ALK2 |
0.731 | -0.003 | -2 | 0.819 |
PRP4 |
0.731 | -0.048 | -3 | 0.100 |
MLK3 |
0.731 | -0.043 | 2 | 0.706 |
IRAK1 |
0.730 | -0.021 | -1 | 0.685 |
VRK2 |
0.730 | -0.130 | 1 | 0.818 |
CK1E |
0.730 | -0.096 | -3 | 0.062 |
HIPK2 |
0.730 | 0.026 | 1 | 0.575 |
JNK3 |
0.730 | 0.008 | 1 | 0.648 |
DAPK3 |
0.730 | 0.124 | -3 | 0.322 |
CDK9 |
0.730 | -0.004 | 1 | 0.650 |
DRAK1 |
0.728 | -0.009 | 1 | 0.727 |
HIPK3 |
0.728 | -0.005 | 1 | 0.702 |
CDK13 |
0.728 | -0.028 | 1 | 0.635 |
P38A |
0.727 | -0.001 | 1 | 0.670 |
CK1D |
0.727 | -0.091 | -3 | 0.050 |
TAO2 |
0.727 | 0.162 | 2 | 0.808 |
CDK18 |
0.727 | 0.007 | 1 | 0.581 |
MST3 |
0.727 | 0.090 | 2 | 0.771 |
MLK4 |
0.726 | -0.082 | 2 | 0.704 |
ZAK |
0.726 | -0.043 | 1 | 0.813 |
DYRK3 |
0.726 | 0.001 | 1 | 0.671 |
HRI |
0.726 | -0.084 | -2 | 0.831 |
CK1A2 |
0.726 | -0.089 | -3 | 0.060 |
DYRK1B |
0.726 | 0.012 | 1 | 0.612 |
CDK14 |
0.726 | 0.025 | 1 | 0.631 |
ACVR2A |
0.725 | -0.063 | -2 | 0.783 |
ACVR2B |
0.725 | -0.057 | -2 | 0.797 |
MEK5 |
0.724 | -0.064 | 2 | 0.813 |
CDK2 |
0.724 | -0.027 | 1 | 0.667 |
PDK1 |
0.724 | 0.068 | 1 | 0.868 |
MEKK1 |
0.724 | -0.107 | 1 | 0.816 |
PERK |
0.724 | -0.099 | -2 | 0.840 |
CDK1 |
0.723 | 0.001 | 1 | 0.594 |
LOK |
0.723 | 0.148 | -2 | 0.830 |
ERK2 |
0.723 | -0.019 | 1 | 0.649 |
NEK5 |
0.723 | -0.042 | 1 | 0.792 |
TLK2 |
0.723 | -0.083 | 1 | 0.746 |
CDK17 |
0.723 | 0.006 | 1 | 0.535 |
ROCK1 |
0.723 | 0.146 | -3 | 0.336 |
P38B |
0.723 | -0.001 | 1 | 0.610 |
CRIK |
0.722 | 0.075 | -3 | 0.271 |
BMPR1A |
0.722 | -0.003 | 1 | 0.672 |
CDK12 |
0.722 | -0.024 | 1 | 0.619 |
P38G |
0.722 | 0.006 | 1 | 0.535 |
DAPK1 |
0.722 | 0.068 | -3 | 0.286 |
NEK11 |
0.721 | 0.013 | 1 | 0.837 |
CDK10 |
0.721 | 0.046 | 1 | 0.613 |
DYRK4 |
0.721 | 0.004 | 1 | 0.593 |
MEKK3 |
0.721 | -0.082 | 1 | 0.794 |
TTBK1 |
0.721 | -0.081 | 2 | 0.618 |
ERK1 |
0.720 | -0.018 | 1 | 0.614 |
MEKK2 |
0.720 | -0.062 | 2 | 0.794 |
PINK1 |
0.719 | -0.155 | 1 | 0.740 |
SLK |
0.719 | 0.128 | -2 | 0.778 |
CDK3 |
0.719 | 0.014 | 1 | 0.547 |
RIPK2 |
0.718 | -0.036 | 1 | 0.806 |
NEK4 |
0.718 | 0.001 | 1 | 0.802 |
CDK16 |
0.718 | 0.025 | 1 | 0.549 |
GRK2 |
0.718 | -0.089 | -2 | 0.697 |
KHS1 |
0.717 | 0.163 | 1 | 0.826 |
PASK |
0.717 | -0.009 | -3 | 0.210 |
HPK1 |
0.717 | 0.127 | 1 | 0.816 |
TLK1 |
0.716 | -0.088 | -2 | 0.799 |
GCK |
0.716 | 0.101 | 1 | 0.802 |
KHS2 |
0.716 | 0.166 | 1 | 0.827 |
LKB1 |
0.716 | -0.030 | -3 | 0.166 |
TNIK |
0.716 | 0.081 | 3 | 0.690 |
MINK |
0.715 | 0.040 | 1 | 0.822 |
MAP3K15 |
0.715 | 0.030 | 1 | 0.815 |
HGK |
0.715 | 0.035 | 3 | 0.686 |
CAMKK1 |
0.715 | -0.116 | -2 | 0.796 |
PLK2 |
0.715 | -0.035 | -3 | 0.088 |
CAMKK2 |
0.714 | -0.076 | -2 | 0.799 |
NEK8 |
0.714 | -0.074 | 2 | 0.797 |
CDK4 |
0.713 | 0.025 | 1 | 0.602 |
GAK |
0.713 | 0.018 | 1 | 0.749 |
NEK1 |
0.713 | 0.006 | 1 | 0.792 |
P38D |
0.713 | -0.000 | 1 | 0.562 |
MAK |
0.711 | 0.003 | -2 | 0.685 |
CK2A2 |
0.711 | 0.015 | 1 | 0.561 |
MPSK1 |
0.711 | -0.061 | 1 | 0.688 |
EEF2K |
0.711 | -0.014 | 3 | 0.693 |
LRRK2 |
0.710 | 0.022 | 2 | 0.819 |
MEKK6 |
0.710 | -0.028 | 1 | 0.775 |
CDK6 |
0.709 | 0.008 | 1 | 0.623 |
GRK3 |
0.709 | -0.088 | -2 | 0.651 |
MST2 |
0.708 | -0.075 | 1 | 0.807 |
MOK |
0.708 | 0.011 | 1 | 0.641 |
YSK1 |
0.708 | 0.037 | 2 | 0.771 |
PBK |
0.708 | 0.035 | 1 | 0.677 |
MST1 |
0.708 | -0.004 | 1 | 0.805 |
MEK2 |
0.707 | -0.081 | 2 | 0.816 |
TAK1 |
0.707 | -0.059 | 1 | 0.824 |
NEK3 |
0.706 | -0.075 | 1 | 0.800 |
GSK3B |
0.706 | -0.039 | 4 | 0.403 |
ERK7 |
0.705 | -0.021 | 2 | 0.489 |
TAO1 |
0.704 | 0.125 | 1 | 0.782 |
STK33 |
0.703 | -0.075 | 2 | 0.611 |
JNK1 |
0.702 | -0.017 | 1 | 0.595 |
GSK3A |
0.701 | -0.036 | 4 | 0.412 |
CK2A1 |
0.700 | -0.005 | 1 | 0.540 |
VRK1 |
0.699 | -0.087 | 2 | 0.829 |
BUB1 |
0.698 | -0.016 | -5 | 0.730 |
PDHK3_TYR |
0.695 | 0.077 | 4 | 0.879 |
HASPIN |
0.695 | 0.021 | -1 | 0.604 |
ASK1 |
0.694 | -0.004 | 1 | 0.811 |
TESK1_TYR |
0.691 | 0.043 | 3 | 0.749 |
LIMK2_TYR |
0.690 | 0.119 | -3 | 0.235 |
MYO3A |
0.690 | 0.018 | 1 | 0.780 |
TTK |
0.689 | -0.042 | -2 | 0.798 |
MAP2K7_TYR |
0.689 | -0.008 | 2 | 0.838 |
CK1G3 |
0.688 | -0.084 | -3 | 0.028 |
MYO3B |
0.687 | -0.028 | 2 | 0.781 |
CK1A |
0.686 | -0.119 | -3 | 0.032 |
PKMYT1_TYR |
0.686 | -0.069 | 3 | 0.712 |
DDR1 |
0.685 | 0.052 | 4 | 0.818 |
RET |
0.685 | 0.005 | 1 | 0.816 |
OSR1 |
0.685 | -0.077 | 2 | 0.773 |
TYK2 |
0.685 | -0.003 | 1 | 0.825 |
PINK1_TYR |
0.685 | -0.018 | 1 | 0.789 |
MAP2K4_TYR |
0.684 | -0.069 | -1 | 0.797 |
ALPHAK3 |
0.684 | -0.051 | -1 | 0.688 |
BIKE |
0.683 | -0.026 | 1 | 0.631 |
PDHK4_TYR |
0.683 | 0.001 | 2 | 0.833 |
MAP2K6_TYR |
0.681 | -0.072 | -1 | 0.790 |
JAK2 |
0.681 | -0.043 | 1 | 0.838 |
NEK10_TYR |
0.680 | 0.059 | 1 | 0.758 |
LIMK1_TYR |
0.680 | -0.043 | 2 | 0.839 |
ROS1 |
0.680 | -0.036 | 3 | 0.622 |
YANK3 |
0.679 | -0.071 | 2 | 0.368 |
BMPR2_TYR |
0.678 | -0.086 | -1 | 0.758 |
STLK3 |
0.678 | -0.086 | 1 | 0.778 |
PDHK1_TYR |
0.678 | -0.108 | -1 | 0.790 |
TYRO3 |
0.677 | -0.059 | 3 | 0.648 |
MST1R |
0.677 | -0.069 | 3 | 0.663 |
TNK1 |
0.676 | 0.041 | 3 | 0.629 |
EPHA6 |
0.676 | -0.055 | -1 | 0.770 |
TNNI3K_TYR |
0.675 | 0.005 | 1 | 0.781 |
CSF1R |
0.675 | -0.082 | 3 | 0.642 |
FGFR1 |
0.673 | -0.024 | 3 | 0.639 |
JAK1 |
0.672 | -0.020 | 1 | 0.817 |
PDGFRB |
0.672 | -0.047 | 3 | 0.664 |
JAK3 |
0.672 | -0.068 | 1 | 0.799 |
INSRR |
0.671 | -0.064 | 3 | 0.620 |
FLT3 |
0.671 | -0.043 | 3 | 0.639 |
FGFR2 |
0.670 | -0.053 | 3 | 0.664 |
AXL |
0.670 | -0.034 | 3 | 0.644 |
EPHB4 |
0.670 | -0.119 | -1 | 0.762 |
DDR2 |
0.668 | 0.040 | 3 | 0.609 |
TEK |
0.668 | -0.085 | 3 | 0.600 |
PDGFRA |
0.667 | -0.063 | 3 | 0.649 |
YES1 |
0.667 | -0.100 | -1 | 0.757 |
TNK2 |
0.667 | -0.056 | 3 | 0.615 |
FER |
0.666 | -0.146 | 1 | 0.771 |
KDR |
0.666 | -0.045 | 3 | 0.615 |
AAK1 |
0.665 | -0.015 | 1 | 0.533 |
EPHB1 |
0.665 | -0.115 | 1 | 0.776 |
EPHB3 |
0.664 | -0.109 | -1 | 0.756 |
ABL2 |
0.664 | -0.100 | -1 | 0.730 |
KIT |
0.664 | -0.108 | 3 | 0.655 |
FGR |
0.664 | -0.134 | 1 | 0.742 |
ALK |
0.663 | -0.055 | 3 | 0.587 |
EPHA4 |
0.663 | -0.097 | 2 | 0.735 |
EPHB2 |
0.661 | -0.120 | -1 | 0.739 |
HCK |
0.661 | -0.147 | -1 | 0.729 |
BTK |
0.660 | -0.134 | -1 | 0.693 |
TXK |
0.660 | -0.099 | 1 | 0.708 |
SRMS |
0.660 | -0.130 | 1 | 0.759 |
LTK |
0.660 | -0.059 | 3 | 0.604 |
NTRK2 |
0.660 | -0.102 | 3 | 0.626 |
MERTK |
0.659 | -0.104 | 3 | 0.631 |
ABL1 |
0.659 | -0.117 | -1 | 0.728 |
FGFR3 |
0.659 | -0.073 | 3 | 0.645 |
ITK |
0.659 | -0.117 | -1 | 0.711 |
LCK |
0.658 | -0.110 | -1 | 0.727 |
TEC |
0.658 | -0.092 | -1 | 0.673 |
NTRK1 |
0.658 | -0.124 | -1 | 0.743 |
FLT4 |
0.657 | -0.079 | 3 | 0.609 |
WEE1_TYR |
0.657 | -0.074 | -1 | 0.682 |
ERBB2 |
0.657 | -0.120 | 1 | 0.761 |
EPHA1 |
0.656 | -0.093 | 3 | 0.614 |
INSR |
0.656 | -0.089 | 3 | 0.594 |
EPHA7 |
0.656 | -0.101 | 2 | 0.749 |
PTK6 |
0.656 | -0.121 | -1 | 0.677 |
FLT1 |
0.654 | -0.104 | -1 | 0.731 |
FRK |
0.654 | -0.109 | -1 | 0.748 |
BLK |
0.653 | -0.117 | -1 | 0.730 |
MET |
0.651 | -0.131 | 3 | 0.638 |
EPHA3 |
0.651 | -0.126 | 2 | 0.720 |
NTRK3 |
0.651 | -0.125 | -1 | 0.705 |
YANK2 |
0.650 | -0.081 | 2 | 0.394 |
BMX |
0.650 | -0.119 | -1 | 0.625 |
LYN |
0.649 | -0.141 | 3 | 0.585 |
CK1G2 |
0.648 | -0.106 | -3 | 0.050 |
PTK2B |
0.648 | -0.085 | -1 | 0.717 |
EPHA5 |
0.647 | -0.105 | 2 | 0.732 |
EGFR |
0.647 | -0.087 | 1 | 0.678 |
FYN |
0.645 | -0.128 | -1 | 0.694 |
FGFR4 |
0.645 | -0.099 | -1 | 0.689 |
CSK |
0.644 | -0.115 | 2 | 0.755 |
MUSK |
0.643 | -0.084 | 1 | 0.649 |
MATK |
0.643 | -0.132 | -1 | 0.658 |
EPHA8 |
0.642 | -0.127 | -1 | 0.714 |
IGF1R |
0.640 | -0.108 | 3 | 0.553 |
SRC |
0.640 | -0.141 | -1 | 0.706 |
EPHA2 |
0.633 | -0.129 | -1 | 0.673 |
PTK2 |
0.630 | -0.099 | -1 | 0.664 |
SYK |
0.630 | -0.119 | -1 | 0.660 |
ERBB4 |
0.629 | -0.100 | 1 | 0.646 |
FES |
0.621 | -0.153 | -1 | 0.620 |
ZAP70 |
0.606 | -0.116 | -1 | 0.581 |