Motif 819 (n=75)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NKT7 | RGPD3 | S928 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| O14544 | SOCS6 | S70 | ochoa | Suppressor of cytokine signaling 6 (SOCS-6) (Cytokine-inducible SH2 protein 4) (CIS-4) (Suppressor of cytokine signaling 4) (SOCS-4) | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor. {ECO:0000250, ECO:0000269|PubMed:21030588}. |
| O14715 | RGPD8 | S927 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O15014 | ZNF609 | S778 | ochoa | Zinc finger protein 609 | Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others. {ECO:0000250|UniProtKB:Q8BZ47}.; FUNCTION: [Isoform 2]: Involved in the regulation of myoblast proliferation during myogenesis. {ECO:0000269|PubMed:28344082}. |
| O15090 | ZNF536 | S1141 | ochoa | Zinc finger protein 536 | Transcriptional repressor that negatively regulates neuron differentiation by repressing retinoic acid-induced gene transcription (PubMed:19398580). Binds and interrupts RARA from binding to retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (PubMed:19398580). Recognizes and binds 2 copies of the core DNA sequence 5'-CCCCCA-3' (PubMed:14621294). {ECO:0000269|PubMed:14621294, ECO:0000269|PubMed:19398580}. |
| O43172 | PRPF4 | Y31 | ochoa | U4/U6 small nuclear ribonucleoprotein Prp4 (PRP4 homolog) (hPrp4) (U4/U6 snRNP 60 kDa protein) (WD splicing factor Prp4) | Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). {ECO:0000269|PubMed:25383878, ECO:0000269|PubMed:28781166}. |
| O43896 | KIF1C | S494 | ochoa | Kinesin-like protein KIF1C | Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:9685376}. |
| O60333 | KIF1B | S527 | ochoa | Kinesin-like protein KIF1B (Klp) (EC 5.6.1.3) | Has a plus-end-directed microtubule motor activity and functions as a motor for transport of vesicles and organelles along microtubules. {ECO:0000269|PubMed:16225668}.; FUNCTION: [Isoform 2]: Has a plus-end-directed microtubule motor activity and functions as a motor for anterograde synaptic vesicle transport along axonal microtubules from the cell body to the presynapse in neuronal cells (By similarity). Functions as a downstream effector in a developmental apoptotic pathway that is activated when nerve growth factor (NGF) becomes limiting for neuronal progenitor cells (PubMed:18334619). {ECO:0000250|UniProtKB:Q60575, ECO:0000269|PubMed:18334619}.; FUNCTION: [Isoform 3]: Has a plus-end-directed microtubule motor activity and functions as a motor for anterograde transport of mitochondria. {ECO:0000269|PubMed:16225668}. |
| O75390 | CS | S190 | ochoa | Citrate synthase, mitochondrial (EC 2.3.3.1) (Citrate (Si)-synthase) | Key enzyme of the Krebs tricarboxylic acid cycle which catalyzes the synthesis of citrate from acetyl coenzyme A and oxaloacetate. {ECO:0000305}. |
| O75410 | TACC1 | S94 | ochoa | Transforming acidic coiled-coil-containing protein 1 (Gastric cancer antigen Ga55) (Taxin-1) | Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863). Might promote the nuclear localization of the receptors (PubMed:20078863). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. {ECO:0000269|PubMed:20078863}. |
| P04180 | LCAT | S205 | psp | Phosphatidylcholine-sterol acyltransferase (EC 2.3.1.43) (1-alkyl-2-acetylglycerophosphocholine esterase) (EC 3.1.1.47) (Lecithin-cholesterol acyltransferase) (Phospholipid-cholesterol acyltransferase) (Platelet-activating factor acetylhydrolase) (PAF acetylhydrolase) | Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs) (PubMed:10329423, PubMed:19065001, PubMed:26195816). The cholesterol ester is then transported back to the liver. Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines (PubMed:8820107). Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms (PubMed:10722751). Catalyzes the hydrolysis of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor or PAF) to 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) (PubMed:8016111). Also catalyzes the transfer of the acetate group from PAF to 1-hexadecanoyl-sn-glycero-3-phosphocholine forming lyso-PAF (PubMed:8016111). Catalyzes the esterification of (24S)-hydroxycholesterol (24(S)OH-C), also known as cerebrosterol to produce 24(S)OH-C monoesters (PubMed:24620755). {ECO:0000269|PubMed:10329423, ECO:0000269|PubMed:10722751, ECO:0000269|PubMed:12354767, ECO:0000269|PubMed:14636062, ECO:0000269|PubMed:19065001, ECO:0000269|PubMed:24620755, ECO:0000269|PubMed:26195816, ECO:0000269|PubMed:8016111, ECO:0000269|PubMed:8820107}. |
| P09874 | PARP1 | S257 | ochoa | Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)] | Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:17177976, PubMed:18055453, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:20388712, PubMed:21680843, PubMed:22582261, PubMed:23230272, PubMed:25043379, PubMed:26344098, PubMed:26626479, PubMed:26626480, PubMed:30104678, PubMed:31796734, PubMed:32028527, PubMed:32241924, PubMed:32358582, PubMed:33186521, PubMed:34465625, PubMed:34737271). Mediates glutamate, aspartate, serine, histidine or tyrosine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:19764761, PubMed:25043379, PubMed:28190768, PubMed:29954836, PubMed:35393539, PubMed:7852410, PubMed:9315851). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:33186521, PubMed:34874266). Specificity for the different amino acids is conferred by interacting factors, such as HPF1 and NMNAT1 (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 confers serine specificity by completing the PARP1 active site (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Also catalyzes tyrosine ADP-ribosylation of target proteins following interaction with HPF1 (PubMed:29954836, PubMed:30257210). Following interaction with NMNAT1, catalyzes glutamate and aspartate ADP-ribosylation of target proteins; NMNAT1 confers glutamate and aspartate specificity (By similarity). PARP1 initiates the repair of DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones (H2BS6ADPr and H3S10ADPr), thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272, PubMed:27067600, PubMed:34465625, PubMed:34874266). HPF1 initiates serine ADP-ribosylation but restricts the polymerase activity of PARP1 in order to limit the length of poly-ADP-ribose chains (PubMed:33683197, PubMed:34732825, PubMed:34795260). In addition to base excision repair (BER) pathway, also involved in double-strand breaks (DSBs) repair: together with TIMELESS, accumulates at DNA damage sites and promotes homologous recombination repair by mediating poly-ADP-ribosylation (PubMed:26344098, PubMed:30356214). Mediates the poly-ADP-ribosylation of a number of proteins, including itself, APLF, CHFR, RPA1 and NFAT5 (PubMed:17396150, PubMed:19764761, PubMed:24906880, PubMed:34049076). In addition to proteins, also able to ADP-ribosylate DNA: catalyzes ADP-ribosylation of DNA strand break termini containing terminal phosphates and a 2'-OH group in single- and double-stranded DNA, respectively (PubMed:27471034). Required for PARP9 and DTX3L recruitment to DNA damage sites (PubMed:23230272). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). PARP1-mediated DNA repair in neurons plays a role in sleep: senses DNA damage in neurons and promotes sleep, facilitating efficient DNA repair (By similarity). In addition to DNA repair, also involved in other processes, such as transcription regulation, programmed cell death, membrane repair, adipogenesis and innate immunity (PubMed:15607977, PubMed:17177976, PubMed:19344625, PubMed:27256882, PubMed:32315358, PubMed:32844745, PubMed:35124853, PubMed:35393539, PubMed:35460603). Acts as a repressor of transcription: binds to nucleosomes and modulates chromatin structure in a manner similar to histone H1, thereby altering RNA polymerase II (PubMed:15607977, PubMed:22464733). Acts both as a positive and negative regulator of transcription elongation, depending on the context (PubMed:27256882, PubMed:35393539). Acts as a positive regulator of transcription elongation by mediating poly-ADP-ribosylation of NELFE, preventing RNA-binding activity of NELFE and relieving transcription pausing (PubMed:27256882). Acts as a negative regulator of transcription elongation in response to DNA damage by catalyzing poly-ADP-ribosylation of CCNT1, disrupting the phase separation activity of CCNT1 and subsequent activation of CDK9 (PubMed:35393539). Involved in replication fork progression following interaction with CARM1: mediates poly-ADP-ribosylation at replication forks, slowing fork progression (PubMed:33412112). Poly-ADP-ribose chains generated by PARP1 also play a role in poly-ADP-ribose-dependent cell death, a process named parthanatos (By similarity). Also acts as a negative regulator of the cGAS-STING pathway (PubMed:32315358, PubMed:32844745, PubMed:35460603). Acts by mediating poly-ADP-ribosylation of CGAS: PARP1 translocates into the cytosol following phosphorylation by PRKDC and catalyzes poly-ADP-ribosylation and inactivation of CGAS (PubMed:35460603). Acts as a negative regulator of adipogenesis: catalyzes poly-ADP-ribosylation of histone H2B on 'Glu-35' (H2BE35ADPr) following interaction with NMNAT1, inhibiting phosphorylation of H2B at 'Ser-36' (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (By similarity). Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000250|UniProtKB:P11103, ECO:0000269|PubMed:15607977, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:17396150, ECO:0000269|PubMed:18055453, ECO:0000269|PubMed:18172500, ECO:0000269|PubMed:19344625, ECO:0000269|PubMed:19661379, ECO:0000269|PubMed:19764761, ECO:0000269|PubMed:20388712, ECO:0000269|PubMed:21680843, ECO:0000269|PubMed:22464733, ECO:0000269|PubMed:22582261, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:24906880, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:26344098, ECO:0000269|PubMed:26626479, ECO:0000269|PubMed:26626480, ECO:0000269|PubMed:27067600, ECO:0000269|PubMed:27256882, ECO:0000269|PubMed:27257257, ECO:0000269|PubMed:27471034, ECO:0000269|PubMed:28190768, ECO:0000269|PubMed:29954836, ECO:0000269|PubMed:30104678, ECO:0000269|PubMed:30257210, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:31796734, ECO:0000269|PubMed:32028527, ECO:0000269|PubMed:32241924, ECO:0000269|PubMed:32315358, ECO:0000269|PubMed:32358582, ECO:0000269|PubMed:32844745, ECO:0000269|PubMed:33186521, ECO:0000269|PubMed:33412112, ECO:0000269|PubMed:33589610, ECO:0000269|PubMed:33683197, ECO:0000269|PubMed:34049076, ECO:0000269|PubMed:34465625, ECO:0000269|PubMed:34625544, ECO:0000269|PubMed:34732825, ECO:0000269|PubMed:34737271, ECO:0000269|PubMed:34795260, ECO:0000269|PubMed:34874266, ECO:0000269|PubMed:35124853, ECO:0000269|PubMed:35393539, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:7852410, ECO:0000269|PubMed:9315851}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed C-terminus]: Promotes AIFM1-mediated apoptosis (PubMed:33168626). This form, which translocates into the cytoplasm following cleavage by caspase-3 (CASP3) and caspase-7 (CASP7) in response to apoptosis, is auto-poly-ADP-ribosylated and serves as a poly-ADP-ribose carrier to induce AIFM1-mediated apoptosis (PubMed:33168626). {ECO:0000269|PubMed:33168626}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed N-terminus]: This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis. {ECO:0000269|PubMed:35104452}. |
| P0DJD0 | RGPD1 | S912 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | S920 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P11055 | MYH3 | S644 | ochoa | Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE) | Muscle contraction. |
| P12882 | MYH1 | S647 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12883 | MYH7 | S643 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P13533 | MYH6 | S645 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P13535 | MYH8 | S646 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
| P14618 | PKM | S97 | ochoa|psp | Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (Tyrosine-protein kinase PKM2) (EC 2.7.10.2) (p58) | Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723, PubMed:20847263). The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production (PubMed:15996096, PubMed:1854723, PubMed:20847263). The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival (PubMed:15996096, PubMed:1854723, PubMed:20847263). {ECO:0000269|PubMed:15996096, ECO:0000269|PubMed:1854723, ECO:0000269|PubMed:20847263}.; FUNCTION: [Isoform M2]: Isoform specifically expressed during embryogenesis that has low pyruvate kinase activity by itself and requires allosteric activation by D-fructose 1,6-bisphosphate (FBP) for pyruvate kinase activity (PubMed:18337823, PubMed:20847263). In addition to its pyruvate kinase activity in the cytoplasm, also acts as a regulator of transcription in the nucleus by acting as a protein kinase (PubMed:18191611, PubMed:21620138, PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661). Translocates into the nucleus in response to various signals, such as EGF receptor activation, and homodimerizes, leading to its conversion into a protein threonine- and tyrosine-protein kinase (PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661, PubMed:26787900). Catalyzes phosphorylation of STAT3 at 'Tyr-705' and histone H3 at 'Thr-11' (H3T11ph), leading to activate transcription (PubMed:22306293, PubMed:22901803, PubMed:24120661). Its ability to activate transcription plays a role in cancer cells by promoting cell proliferation and promote tumorigenesis (PubMed:18337823, PubMed:22901803, PubMed:26787900). Promotes the expression of the immune checkpoint protein CD274 in BMAL1-deficient macrophages (By similarity). May also act as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum-destined mRNAs (By similarity). Plays a role in caspase independent cell death of tumor cells (PubMed:17308100). {ECO:0000250|UniProtKB:P52480, ECO:0000269|PubMed:17308100, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263, ECO:0000269|PubMed:21620138, ECO:0000269|PubMed:22056988, ECO:0000269|PubMed:22306293, ECO:0000269|PubMed:22901803, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:26787900}.; FUNCTION: [Isoform M1]: Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth (PubMed:18337823). In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity (PubMed:20847263). {ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263}. |
| P21796 | VDAC1 | S193 | psp | Non-selective voltage-gated ion channel VDAC1 (Outer mitochondrial membrane protein porin 1) (Plasmalemmal porin) (Porin 31HL) (Porin 31HM) (Voltage-dependent anion-selective channel protein 1) (VDAC-1) (hVDAC1) | Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane (PubMed:10661876, PubMed:11845315, PubMed:18755977, PubMed:30061676, PubMed:8420959). The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis (PubMed:10661876, PubMed:11845315, PubMed:18755977, PubMed:8420959). It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV (PubMed:10661876, PubMed:18755977, PubMed:8420959). The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:18755977, PubMed:8420959). Binds various signaling molecules, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterols cholesterol and oxysterol (PubMed:18755977, PubMed:31015432). In depolarized mitochondria, acts downstream of PRKN and PINK1 to promote mitophagy or prevent apoptosis; polyubiquitination by PRKN promotes mitophagy, while monoubiquitination by PRKN decreases mitochondrial calcium influx which ultimately inhibits apoptosis (PubMed:32047033). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (PubMed:15033708, PubMed:25296756). May mediate ATP export from cells (PubMed:30061676). Part of a complex composed of HSPA9, ITPR1 and VDAC1 that regulates mitochondrial calcium-dependent apoptosis by facilitating calcium transport from the ER lumen to the mitochondria intermembrane space thus providing calcium for the downstream calcium channel MCU that directly releases it into mitochondria matrix (By similarity). Mediates cytochrome c efflux (PubMed:20230784). {ECO:0000250|UniProtKB:Q60932, ECO:0000269|PubMed:10661876, ECO:0000269|PubMed:11845315, ECO:0000269|PubMed:15033708, ECO:0000269|PubMed:18755977, ECO:0000269|PubMed:20230784, ECO:0000269|PubMed:25296756, ECO:0000269|PubMed:30061676, ECO:0000269|PubMed:31015432, ECO:0000269|PubMed:32047033, ECO:0000269|PubMed:8420959}.; FUNCTION: Catalyzes the scrambling of phospholipids across the outer mitochondrial membrane; the mechanism is unrelated to channel activity and is capable of translocating both anionic and zwitterionic phospholipids. {ECO:0000269|PubMed:38065946}. |
| P46013 | MKI67 | S2395 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P48382 | RFX5 | S313 | ochoa | DNA-binding protein RFX5 (Regulatory factor X 5) | Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters. |
| P49321 | NASP | S30 | ochoa | Nuclear autoantigenic sperm protein (NASP) | Component of the histone chaperone network (PubMed:22195965). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:22195965). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000250|UniProtKB:Q99MD9, ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 1]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 2]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}. |
| P49792 | RANBP2 | S1903 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P57764 | GSDMD | S185 | ochoa | Gasdermin-D (Gasdermin domain-containing protein 1) [Cleaved into: Gasdermin-D, N-terminal (GSDMD-NT) (hGSDMD-NTD); Gasdermin-D, C-terminal (GSDMD-CT) (hGSDMD-CTD); Gasdermin-D, p13 (Gasdermin-D, 13 kDa) (13 kDa GSDMD); Gasdermin-D, p40] | [Gasdermin-D]: Precursor of a pore-forming protein that plays a key role in host defense against pathogen infection and danger signals (PubMed:26375003, PubMed:26375259, PubMed:27281216). This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-D, N-terminal) binds to membranes and forms pores, triggering pyroptosis (PubMed:26375003, PubMed:26375259, PubMed:27281216). {ECO:0000269|PubMed:26375003, ECO:0000269|PubMed:26375259, ECO:0000269|PubMed:27281216}.; FUNCTION: [Gasdermin-D, N-terminal]: Promotes pyroptosis in response to microbial infection and danger signals (PubMed:26375003, PubMed:26375259, PubMed:27418190, PubMed:28392147, PubMed:32820063, PubMed:34289345, PubMed:38040708, PubMed:38530158, PubMed:38599239). Produced by the cleavage of gasdermin-D by inflammatory caspases CASP1, CASP4 or CASP5 in response to canonical, as well as non-canonical (such as cytosolic LPS) inflammasome activators (PubMed:26375003, PubMed:26375259, PubMed:27418190). After cleavage, moves to the plasma membrane where it strongly binds to inner leaflet lipids, including monophosphorylated phosphatidylinositols, such as phosphatidylinositol 4-phosphate, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate, as well as phosphatidylinositol (3,4,5)-bisphosphate, and more weakly to phosphatidic acid and phosphatidylserine (PubMed:27281216, PubMed:29898893, PubMed:36227980). Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, allowing the release of mature interleukin-1 (IL1B and IL18) and triggering pyroptosis (PubMed:27281216, PubMed:27418190, PubMed:29898893, PubMed:33883744, PubMed:38040708, PubMed:38530158, PubMed:38599239). Gasdermin pores also allow the release of mature caspase-7 (CASP7) (By similarity). In some, but not all, cells types, pyroptosis is followed by pyroptotic cell death, which is caused by downstream activation of ninjurin-1 (NINJ1), which mediates membrane rupture (cytolysis) (PubMed:33472215, PubMed:37198476). Also forms pores in the mitochondrial membrane, resulting in release of mitochondrial DNA (mtDNA) into the cytosol (By similarity). Gasdermin-D, N-terminal released from pyroptotic cells into the extracellular milieu rapidly binds to and kills both Gram-negative and Gram-positive bacteria, without harming neighboring mammalian cells, as it does not disrupt the plasma membrane from the outside due to lipid-binding specificity (PubMed:27281216). Under cell culture conditions, also active against intracellular bacteria, such as Listeria monocytogenes (By similarity). Also active in response to MAP3K7/TAK1 inactivation by Yersinia toxin YopJ, which triggers cleavage by CASP8 and subsequent activation (By similarity). Required for mucosal tissue defense against enteric pathogens (By similarity). Activation of the non-canonical inflammasome in brain endothelial cells can lead to excessive pyroptosis, leading to blood-brain barrier breakdown (By similarity). Strongly binds to bacterial and mitochondrial lipids, including cardiolipin (PubMed:27281216). Does not bind to unphosphorylated phosphatidylinositol, phosphatidylethanolamine nor phosphatidylcholine (PubMed:27281216). {ECO:0000250|UniProtKB:Q9D8T2, ECO:0000269|PubMed:26375003, ECO:0000269|PubMed:26375259, ECO:0000269|PubMed:27281216, ECO:0000269|PubMed:27418190, ECO:0000269|PubMed:28392147, ECO:0000269|PubMed:29898893, ECO:0000269|PubMed:32820063, ECO:0000269|PubMed:33472215, ECO:0000269|PubMed:33883744, ECO:0000269|PubMed:34289345, ECO:0000269|PubMed:36227980, ECO:0000269|PubMed:37198476, ECO:0000269|PubMed:38040708, ECO:0000269|PubMed:38530158, ECO:0000269|PubMed:38599239}.; FUNCTION: [Gasdermin-D, p13]: Transcription coactivator produced by the cleavage by CASP3 or CASP7 in the upper small intestine in response to dietary antigens (By similarity). Required to maintain food tolerance in small intestine: translocates to the nucleus and acts as a coactivator for STAT1 to induce the transcription of CIITA and MHC class II molecules, which in turn induce type 1 regulatory T (Tr1) cells in upper small intestine (By similarity). {ECO:0000250|UniProtKB:Q9D8T2}.; FUNCTION: [Gasdermin-D, p40]: Produced by the cleavage by papain allergen (PubMed:35794369). After cleavage, moves to the plasma membrane and homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, allowing the specific release of mature interleukin-33 (IL33), promoting type 2 inflammatory immune response (PubMed:35794369). {ECO:0000269|PubMed:35794369}. |
| Q01484 | ANK2 | S1733 | ochoa | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}. |
| Q12756 | KIF1A | S487 | ochoa | Kinesin-like protein KIF1A (EC 5.6.1.3) (Axonal transporter of synaptic vesicles) (Microtubule-based motor KIF1A) (Unc-104- and KIF1A-related protein) (hUnc-104) | Kinesin motor with a plus-end-directed microtubule motor activity (By similarity). It is required for anterograde axonal transport of synaptic vesicle precursors (PubMed:33880452). Also required for neuronal dense core vesicles (DCVs) transport to the dendritic spines and axons. The interaction calcium-dependent with CALM1 increases vesicle motility and interaction with the scaffolding proteins PPFIA2 and TANC2 recruits DCVs to synaptic sites. {ECO:0000250|UniProtKB:F1M4A4, ECO:0000250|UniProtKB:P33173, ECO:0000269|PubMed:33880452}. |
| Q12888 | TP53BP1 | S484 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q13303 | KCNAB2 | S112 | ochoa|psp | Voltage-gated potassium channel subunit beta-2 (EC 1.1.1.-) (K(+) channel subunit beta-2) (Kv-beta-2) (hKvbeta2) | Regulatory subunit of the voltage-gated potassium (Kv) Shaker channels composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits (PubMed:11825900, PubMed:7649300). The beta-2/KCNAB2 cytoplasmic subunit promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore (PubMed:11825900, PubMed:7649300). Promotes the inactivation of Kv1.4/KCNA4 and Kv1.5/KCNA5 alpha subunit-containing channels (PubMed:11825900, PubMed:7649300). Displays nicotinamide adenine dinucleotide phosphate (NADPH)-dependent aldoketoreductase activity by catalyzing the NADPH-dependent reduction of a wide range of aldehyde and ketone substrates (By similarity). Substrate specificity includes methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro, no physiological substrate identified yet) (By similarity). The binding of oxidized and reduced nucleotide alters Kv channel gating and may contribute to dynamic fine tuning of cell excitability (By similarity). Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability (By similarity). {ECO:0000250|UniProtKB:P62482, ECO:0000250|UniProtKB:P62483, ECO:0000269|PubMed:11825900, ECO:0000269|PubMed:7649300}. |
| Q13561 | DCTN2 | S203 | ochoa | Dynactin subunit 2 (50 kDa dynein-associated polypeptide) (Dynactin complex 50 kDa subunit) (DCTN-50) (p50 dynamitin) | Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. In the dynactin soulder domain, binds the ACTR1A filament and acts as a molecular ruler to determine the length (By similarity). Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (By similarity). {ECO:0000250|UniProtKB:A0A5G2QD80, ECO:0000250|UniProtKB:Q99KJ8}. |
| Q14157 | UBAP2L | S356 | ochoa | Ubiquitin-associated protein 2-like (Protein NICE-4) (RNA polymerase II degradation factor UBAP2L) | Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs) (By similarity). Is a regulator of stress granule assembly, required for their efficient formation (PubMed:29395067, PubMed:35977029). Required for proper brain development and neocortex lamination (By similarity). {ECO:0000250|UniProtKB:Q80X50, ECO:0000269|PubMed:29395067, ECO:0000269|PubMed:35633597}. |
| Q14683 | SMC1A | S971 | ochoa | Structural maintenance of chromosomes protein 1A (SMC protein 1A) (SMC-1-alpha) (SMC-1A) (Sb1.8) | Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint. {ECO:0000269|PubMed:11877377}. |
| Q14722 | KCNAB1 | S164 | ochoa | Voltage-gated potassium channel subunit beta-1 (EC 1.1.1.-) (K(+) channel subunit beta-1) (Kv-beta-1) | Regulatory subunit of the voltage-gated potassium (Kv) Shaker channels composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits (PubMed:17156368, PubMed:17540341, PubMed:19713757, PubMed:7499366, PubMed:7603988). The beta-1/KCNAB1 cytoplasmic subunit mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (PubMed:9763623). Promotes the inactivation of Kv1.1/KCNA1, Kv1.2/KCNA2, Kv1.4/KCNA4, Kv1.5/KCNA5 and Kv1.6/KCNA6 alpha subunit-containing channels (PubMed:12077175, PubMed:12130714, PubMed:15361858, PubMed:17156368, PubMed:17540341, PubMed:19713757, PubMed:7499366, PubMed:7603988, PubMed:7649300, PubMed:7890764, PubMed:9763623). Displays nicotinamide adenine dinucleotide phosphate (NADPH)-dependent aldoketoreductase activity by catalyzing the NADPH-dependent reduction of a variety of endogenous aldehydes and ketones (By similarity). The binding of NADPH is required for efficient down-regulation of potassium channel activity (PubMed:17540341). Oxidation of the bound NADPH restrains N-terminal domain from blocking the channel, thereby decreasing N-type inactivation of potassium channel activity (By similarity). {ECO:0000250|UniProtKB:P63144, ECO:0000269|PubMed:12077175, ECO:0000269|PubMed:12130714, ECO:0000269|PubMed:15361858, ECO:0000269|PubMed:17156368, ECO:0000269|PubMed:17540341, ECO:0000269|PubMed:19713757, ECO:0000269|PubMed:7499366, ECO:0000269|PubMed:7603988, ECO:0000269|PubMed:7649300, ECO:0000269|PubMed:7890764, ECO:0000269|PubMed:9763623}.; FUNCTION: [Isoform KvB1.2]: Isoform KvB1.2 shows no effect on KCNA1, KCNA2 or KCNB1. {ECO:0000269|PubMed:7890032, ECO:0000269|PubMed:7890764}. |
| Q15139 | PRKD1 | S549 | ochoa | Serine/threonine-protein kinase D1 (EC 2.7.11.13) (Protein kinase C mu type) (Protein kinase D) (nPKC-D1) (nPKC-mu) | Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response (PubMed:10764790, PubMed:12505989, PubMed:12637538, PubMed:17442957, PubMed:18509061, PubMed:19135240, PubMed:19211839). Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation (PubMed:10523301). Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the heterotrimeric G-protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane. May act by activating the lipid kinase phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the local synthesis of phosphorylated inositol lipids, which induces a sequential production of DAG, phosphatidic acid (PA) and lyso-PA (LPA) that are necessary for membrane fission and generation of specific transport carriers to the cell surface. Under oxidative stress, is phosphorylated at Tyr-463 via SRC-ABL1 and contributes to cell survival by activating IKK complex and subsequent nuclear translocation and activation of NFKB1 (PubMed:12505989). Involved in cell migration by regulating integrin alpha-5/beta-3 recycling and promoting its recruitment in newly forming focal adhesion. In osteoblast differentiation, mediates the bone morphogenetic protein 2 (BMP2)-induced nuclear export of HDAC7, which results in the inhibition of HDAC7 transcriptional repression of RUNX2 (PubMed:18509061). In neurons, plays an important role in neuronal polarity by regulating the biogenesis of TGN-derived dendritic vesicles, and is involved in the maintenance of dendritic arborization and Golgi structure in hippocampal cells. May potentiate mitogenesis induced by the neuropeptide bombesin or vasopressin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. Plays an important role in the proliferative response induced by low calcium in keratinocytes, through sustained activation of MAPK1/3 (ERK1/2) pathway. Downstream of novel PKC signaling, plays a role in cardiac hypertrophy by phosphorylating HDAC5, which in turn triggers XPO1/CRM1-dependent nuclear export of HDAC5, MEF2A transcriptional activation and induction of downstream target genes that promote myocyte hypertrophy and pathological cardiac remodeling (PubMed:18332134). Mediates cardiac troponin I (TNNI3) phosphorylation at the PKA sites, which results in reduced myofilament calcium sensitivity, and accelerated crossbridge cycling kinetics. The PRKD1-HDAC5 pathway is also involved in angiogenesis by mediating VEGFA-induced specific subset of gene expression, cell migration, and tube formation (PubMed:19211839). In response to VEGFA, is necessary and required for HDAC7 phosphorylation which induces HDAC7 nuclear export and endothelial cell proliferation and migration. During apoptosis induced by cytarabine and other genotoxic agents, PRKD1 is cleaved by caspase-3 at Asp-378, resulting in activation of its kinase function and increased sensitivity of cells to the cytotoxic effects of genotoxic agents (PubMed:10764790). In epithelial cells, is required for transducing flagellin-stimulated inflammatory responses by binding and phosphorylating TLR5, which contributes to MAPK14/p38 activation and production of inflammatory cytokines (PubMed:17442957). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity). May play a role in inflammatory response by mediating activation of NF-kappa-B. May be involved in pain transmission by directly modulating TRPV1 receptor (PubMed:15471852). Plays a role in activated KRAS-mediated stabilization of ZNF304 in colorectal cancer (CRC) cells (PubMed:24623306). Regulates nuclear translocation of transcription factor TFEB in macrophages upon live S.enterica infection (By similarity). {ECO:0000250|UniProtKB:Q62101, ECO:0000269|PubMed:10523301, ECO:0000269|PubMed:10764790, ECO:0000269|PubMed:12505989, ECO:0000269|PubMed:12637538, ECO:0000269|PubMed:15471852, ECO:0000269|PubMed:17442957, ECO:0000269|PubMed:18332134, ECO:0000269|PubMed:18509061, ECO:0000269|PubMed:19135240, ECO:0000269|PubMed:19211839, ECO:0000269|PubMed:24623306}. |
| Q15785 | TOMM34 | S280 | ochoa | Mitochondrial import receptor subunit TOM34 (hTom34) (Translocase of outer membrane 34 kDa subunit) | Plays a role in the import of cytosolically synthesized preproteins into mitochondria. Binds the mature portion of precursor proteins. Interacts with cellular components, and possesses weak ATPase activity. May be a chaperone-like protein that helps to keep newly synthesized precursors in an unfolded import compatible state. {ECO:0000269|PubMed:10101285, ECO:0000269|PubMed:11913975, ECO:0000269|PubMed:9324309}. |
| Q15813 | TBCE | S408 | ochoa | Tubulin-specific chaperone E (Tubulin-folding cofactor E) | Tubulin-folding protein; involved in the second step of the tubulin folding pathway and in the regulation of tubulin heterodimer dissociation. Required for correct organization of microtubule cytoskeleton and mitotic splindle, and maintenance of the neuronal microtubule network. {ECO:0000269|PubMed:11847227, ECO:0000269|PubMed:27666369}. |
| Q5VUB5 | FAM171A1 | S494 | ochoa | Protein FAM171A1 (Astroprincin) (APCN) | Involved in the regulation of the cytoskeletal dynamics, plays a role in actin stress fiber formation. {ECO:0000269|PubMed:30312582}. |
| Q68DN1 | SPATA31H1 | S178 | ochoa | Spermatogenesis-associated protein 31H1 | None |
| Q6PJT7 | ZC3H14 | S475 | ochoa | Zinc finger CCCH domain-containing protein 14 (Mammalian suppressor of tau pathology-2) (MSUT-2) (Renal carcinoma antigen NY-REN-37) | RNA-binding protein involved in the biogenesis of circular RNAs (circRNAs), which are produced by back-splicing circularization of pre-mRNAs (PubMed:39461343). Acts by binding to both exon-intron boundary and 3'-UTR of pre-mRNAs to promote circRNA biogenesis through dimerization and the association with the spliceosome (PubMed:39461343). Required for spermatogenesis via involvement in circRNA biogenesis (PubMed:39461343). Regulates the pre-mRNA processing of ATP5MC1; preventing its degradation (PubMed:27563065). Also binds the poly(A) tail of mRNAs; controlling poly(A) length in neuronal cells (PubMed:17630287, PubMed:24671764). {ECO:0000269|PubMed:17630287, ECO:0000269|PubMed:24671764, ECO:0000269|PubMed:27563065, ECO:0000269|PubMed:39461343}. |
| Q6ZMI0 | PPP1R21 | S93 | ochoa | Protein phosphatase 1 regulatory subunit 21 (Coiled-coil domain-containing protein 128) (Ferry endosomal RAB5 effector complex subunit 2) (Fy-2) (KLRAQ motif-containing protein 1) | Component of the FERRY complex (Five-subunit Endosomal Rab5 and RNA/ribosome intermediary) (PubMed:37267905, PubMed:37267906). The FERRY complex directly interacts with mRNAs and RAB5A, and functions as a RAB5A effector involved in the localization and the distribution of specific mRNAs most likely by mediating their endosomal transport. The complex recruits mRNAs and ribosomes to early endosomes through direct mRNA-interaction (PubMed:37267905). In the complex, PPP1R21 serves as a binding hub connecting all five complex subunits and mediating the binding to mRNA and early endosomes via RAB5A (PubMed:37267906). Putative regulator of protein phosphatase 1 (PP1) activity (PubMed:19389623). May play a role in the endosomal sorting process or in endosome maturation pathway (Probable) (PubMed:30520571). {ECO:0000269|PubMed:30520571, ECO:0000269|PubMed:37267905, ECO:0000269|PubMed:37267906, ECO:0000305|PubMed:19389623}. |
| Q76N89 | HECW1 | S874 | ochoa | E3 ubiquitin-protein ligase HECW1 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 1) (HECT-type E3 ubiquitin transferase HECW1) (NEDD4-like E3 ubiquitin-protein ligase 1) (hNEDL1) | E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS. {ECO:0000269|PubMed:14684739}. |
| Q7L576 | CYFIP1 | S583 | ochoa | Cytoplasmic FMR1-interacting protein 1 (Specifically Rac1-associated protein 1) (Sra-1) (p140sra-1) | Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). May act as an invasion suppressor in cancers. {ECO:0000250|UniProtKB:Q7TMB8, ECO:0000269|PubMed:16260607, ECO:0000269|PubMed:19524508, ECO:0000269|PubMed:21107423, ECO:0000269|PubMed:9417078}. |
| Q7Z3J3 | RGPD4 | S928 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z5K2 | WAPL | S347 | ochoa | Wings apart-like protein homolog (Friend of EBNA2 protein) (WAPL cohesin release factor) | Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin (PubMed:26299517). Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15150110, ECO:0000269|PubMed:17112726, ECO:0000269|PubMed:17113138, ECO:0000269|PubMed:19696148, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:21111234, ECO:0000269|PubMed:23776203, ECO:0000269|PubMed:26299517}. |
| Q8N587 | ZNF561 | S261 | ochoa | Zinc finger protein 561 | May be involved in transcriptional regulation. |
| Q8N8E3 | CEP112 | S242 | ochoa | Centrosomal protein of 112 kDa (Cep112) (Coiled-coil domain-containing protein 46) | None |
| Q8WVJ9 | TWIST2 | S57 | ochoa | Twist-related protein 2 (Class A basic helix-loop-helix protein 39) (bHLHa39) (Dermis-expressed protein 1) (Dermo-1) | Binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of pro-inflammatory cytokines such as TNFA and IL1B. Involved in postnatal glycogen storage and energy metabolism (By similarity). Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors. {ECO:0000250, ECO:0000269|PubMed:11062344}. |
| Q8WWK9 | CKAP2 | S651 | ochoa | Cytoskeleton-associated protein 2 (CTCL tumor antigen se20-10) (Tumor- and microtubule-associated protein) | Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner (By similarity). {ECO:0000250}. |
| Q969S3 | ZNF622 | S314 | psp | Cytoplasmic 60S subunit biogenesis factor ZNF622 (Zinc finger protein 622) (Zinc finger-like protein 9) | Pre-60S-associated cytoplasmic factor involved in the cytoplasmic maturation of the 60S subunit. {ECO:0000269|PubMed:33711283}. |
| Q96F07 | CYFIP2 | S607 | ochoa | Cytoplasmic FMR1-interacting protein 2 (p53-inducible protein 121) | Involved in T-cell adhesion and p53/TP53-dependent induction of apoptosis. Does not bind RNA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). {ECO:0000250|UniProtKB:Q5SQX6, ECO:0000269|PubMed:10449408, ECO:0000269|PubMed:15048733, ECO:0000269|PubMed:17245118}. |
| Q96I25 | RBM17 | S293 | ochoa | Splicing factor 45 (45 kDa-splicing factor) (RNA-binding motif protein 17) | Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. Promotes the utilization of a cryptic splice site created by the beta-110 mutation in the HBB gene. The resulting frameshift leads to sickle cell anemia. {ECO:0000269|PubMed:12015979, ECO:0000269|PubMed:17589525}. |
| Q99666 | RGPD5 | S927 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q9BY44 | EIF2A | S249 | ochoa | Eukaryotic translation initiation factor 2A (eIF-2A) (65 kDa eukaryotic translation initiation factor 2A) [Cleaved into: Eukaryotic translation initiation factor 2A, N-terminally processed] | Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. {ECO:0000269|PubMed:12133843}. |
| Q9C0D6 | FHDC1 | S500 | ochoa | FH2 domain-containing protein 1 (Inverted formin-1) | Microtubule-associated formin which regulates both actin and microtubule dynamics. Induces microtubule acetylation and stabilization and actin stress fiber formation (PubMed:18815276). Regulates Golgi ribbon formation (PubMed:26564798). Required for normal cilia assembly. Early in cilia assembly, may assist in the maturation and positioning of the centrosome/basal body, and once cilia assembly has initiated, may also promote cilia elongation by inhibiting disassembly (PubMed:29742020). {ECO:0000269|PubMed:18815276, ECO:0000269|PubMed:26564798, ECO:0000269|PubMed:29742020}. |
| Q9H6U6 | BCAS3 | S850 | ochoa | BCAS3 microtubule associated cell migration factor (Breast carcinoma-amplified sequence 3) (GAOB1) | Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation (By similarity). Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin. Plays a regulatory role in autophagic activity. In complex with PHAF1, associates with the preautophagosomal structure during both non-selective and selective autophagy (PubMed:33499712). Probably binds phosphatidylinositol 3-phosphate (PtdIns3P) which would mediate the recruitment preautophagosomal structures (PubMed:33499712). {ECO:0000250|UniProtKB:Q8CCN5, ECO:0000269|PubMed:17505058, ECO:0000269|PubMed:33499712}. |
| Q9NR48 | ASH1L | S24 | ochoa | Histone-lysine N-methyltransferase ASH1L (EC 2.1.1.359) (EC 2.1.1.367) (ASH1-like protein) (huASH1) (Absent small and homeotic disks protein 1 homolog) (Lysine N-methyltransferase 2H) | Histone methyltransferase specifically trimethylating 'Lys-36' of histone H3 forming H3K36me3 (PubMed:21239497). Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). The physiological significance of the H3K9me1 activity is unclear (By similarity). {ECO:0000250|UniProtKB:Q99MY8, ECO:0000269|PubMed:21239497}. |
| Q9NSC5 | HOMER3 | S256 | ochoa | Homer protein homolog 3 (Homer-3) | Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed:18218901). {ECO:0000269|PubMed:18218901}. |
| Q9P2Y5 | UVRAG | S582 | psp | UV radiation resistance-associated gene protein (p63) | Versatile protein that is involved in regulation of different cellular pathways implicated in membrane trafficking. Involved in regulation of the COPI-dependent retrograde transport from Golgi and the endoplasmic reticulum by associating with the NRZ complex; the function is dependent on its binding to phosphatidylinositol 3-phosphate (PtdIns(3)P) (PubMed:16799551, PubMed:18552835, PubMed:20643123, PubMed:24056303, PubMed:28306502). During autophagy acts as a regulatory subunit of the alternative PI3K complex II (PI3KC3-C2) that mediates formation of phosphatidylinositol 3-phosphate and is believed to be involved in maturation of autophagosomes and endocytosis. Activates lipid kinase activity of PIK3C3 (PubMed:16799551, PubMed:20643123, PubMed:24056303, PubMed:28306502). Involved in the regulation of degradative endocytic trafficking and cytokinesis, and in regulation of ATG9A transport from the Golgi to the autophagosome; the functions seems to implicate its association with PI3KC3-C2 (PubMed:16799551, PubMed:20643123, PubMed:24056303). Involved in maturation of autophagosomes and degradative endocytic trafficking independently of BECN1 but depending on its association with a class C Vps complex (possibly the HOPS complex); the association is also proposed to promote autophagosome recruitment and activation of Rab7 and endosome-endosome fusion events (PubMed:18552835, PubMed:28306502). Enhances class C Vps complex (possibly HOPS complex) association with a SNARE complex and promotes fusogenic SNARE complex formation during late endocytic membrane fusion (PubMed:24550300). In case of negative-strand RNA virus infection is required for efficient virus entry, promotes endocytic transport of virions and is implicated in a VAMP8-specific fusogenic SNARE complex assembly (PubMed:24550300). {ECO:0000269|PubMed:18552835, ECO:0000269|PubMed:20643123, ECO:0000269|PubMed:24056303, ECO:0000269|PubMed:28306502, ECO:0000305}.; FUNCTION: Involved in maintaining chromosomal stability. Promotes DNA double-strand break (DSB) repair by association with DNA-dependent protein kinase complex DNA-PK and activating it in non-homologous end joining (NHEJ) (PubMed:22542840). Required for centrosome stability and proper chromosome segregation (PubMed:22542840). {ECO:0000269|PubMed:22542840}. |
| Q9UI14 | RABAC1 | S28 | ochoa | Prenylated Rab acceptor protein 1 (PRA1 family protein 1) | General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI. {ECO:0000250|UniProtKB:O35394}. |
| Q9UKA2 | FBXL4 | S268 | ochoa | F-box/LRR-repeat protein 4 (F-box and leucine-rich repeat protein 4) (F-box protein FBL4/FBL5) | Substrate-recognition component of the mitochondria-localized SCF-FBXL4 ubiquitin E3 ligase complex that plays a role in the restriction of mitophagy by controlling the degradation of BNIP3 and NIX mitophagy receptors (PubMed:36896912, PubMed:38992176). Rescues also mitochondrial injury through reverting hyperactivation of DRP1-mediated mitochondrial fission (By similarity). {ECO:0000250|UniProtKB:Q8BH70, ECO:0000269|PubMed:36896912, ECO:0000269|PubMed:38992176}. |
| Q9UKX2 | MYH2 | S649 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UMS6 | SYNPO2 | S88 | ochoa | Synaptopodin-2 (Genethonin-2) (Myopodin) | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. |
| Q9Y2G3 | ATP11B | S446 | ochoa | Phospholipid-transporting ATPase IF (EC 7.6.2.1) (ATPase IR) (ATPase class VI type 11B) (P4-ATPase flippase complex alpha subunit ATP11B) | Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of intracellular membranes (PubMed:30018401). May contribute to the maintenance of membrane lipid asymmetry in endosome compartment (PubMed:30018401). {ECO:0000269|PubMed:30018401}. |
| Q9Y623 | MYH4 | S647 | ochoa | Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) | Muscle contraction. |
| Q9Y6B7 | AP4B1 | S593 | ochoa | AP-4 complex subunit beta-1 (AP-4 adaptor complex subunit beta) (Adaptor-related protein complex 4 subunit beta-1) (Beta subunit of AP-4) (Beta4-adaptin) | Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways (PubMed:10066790, PubMed:10436028). AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (Probable). {ECO:0000269|PubMed:10066790, ECO:0000269|PubMed:10436028, ECO:0000305|PubMed:10066790, ECO:0000305|PubMed:10436028}. |
| P13798 | APEH | S175 | Sugiyama | Acylamino-acid-releasing enzyme (AARE) (EC 3.4.19.1) (Acyl-peptide hydrolase) (APH) (Acylaminoacyl-peptidase) (Oxidized protein hydrolase) (OPH) | This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus (PubMed:10719179, PubMed:1740429, PubMed:2006156). It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser (By similarity). Also, involved in the degradation of oxidized and glycated proteins (PubMed:10719179). {ECO:0000250|UniProtKB:P13676, ECO:0000269|PubMed:10719179, ECO:0000269|PubMed:1740429, ECO:0000269|PubMed:2006156}. |
| P68431 | H3C1 | Y42 | EPSD | Histone H3.1 (Histone H3/a) (Histone H3/b) (Histone H3/c) (Histone H3/d) (Histone H3/f) (Histone H3/h) (Histone H3/i) (Histone H3/j) (Histone H3/k) (Histone H3/l) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| P35613 | BSG | S278 | Sugiyama | Basigin (5F7) (Collagenase stimulatory factor) (Extracellular matrix metalloproteinase inducer) (EMMPRIN) (Hepatoma-associated antigen) (HAb18G) (Leukocyte activation antigen M6) (OK blood group antigen) (Tumor cell-derived collagenase stimulatory factor) (TCSF) (CD antigen CD147) | [Isoform 1]: Essential for normal retinal maturation and development (By similarity). Acts as a retinal cell surface receptor for NXNL1 and plays an important role in NXNL1-mediated survival of retinal cone photoreceptors (PubMed:25957687). In association with glucose transporter SLC16A1/GLUT1 and NXNL1, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors (PubMed:25957687). May act as a potent stimulator of IL6 secretion in multiple cell lines that include monocytes (PubMed:21620857). {ECO:0000250|UniProtKB:P18572, ECO:0000269|PubMed:21620857, ECO:0000269|PubMed:25957687}.; FUNCTION: [Isoform 1]: (Microbial infection) Erythrocyte receptor for P.falciparum RH5 which is essential for erythrocyte invasion by the merozoite stage of P.falciparum isolates 3D7 and Dd2. {ECO:0000269|PubMed:22080952}.; FUNCTION: [Isoform 2]: Signaling receptor for cyclophilins, essential for PPIA/CYPA and PPIB/CYPB-dependent signaling related to chemotaxis and adhesion of immune cells (PubMed:11688976, PubMed:11943775). Plays an important role in targeting monocarboxylate transporters SLC16A1/GLUT1, SLC16A11 and SLC16A12 to the plasma membrane (PubMed:17127621, PubMed:21778275, PubMed:28666119). Acts as a coreceptor for vascular endothelial growth factor receptor 2 (KDR/VEGFR2) in endothelial cells enhancing its VEGFA-mediated activation and downstream signaling (PubMed:25825981). Promotes angiogenesis through EPAS1/HIF2A-mediated up-regulation of VEGFA (isoform VEGF-165 and VEGF-121) and KDR/VEGFR2 in endothelial cells (PubMed:19837976). Plays a key role in regulating tumor growth, invasion, metastasis and neoangiogenesis by stimulating the production and release of extracellular matrix metalloproteinases and KDR/VEGFR2 by both tumor cells and stromal cells (fibroblasts and endothelial cells) (PubMed:11992541, PubMed:12553375, PubMed:15833850). {ECO:0000269|PubMed:11688976, ECO:0000269|PubMed:11943775, ECO:0000269|PubMed:11992541, ECO:0000269|PubMed:12553375, ECO:0000269|PubMed:15833850, ECO:0000269|PubMed:17127621, ECO:0000269|PubMed:19837976, ECO:0000269|PubMed:21778275, ECO:0000269|PubMed:25825981, ECO:0000269|PubMed:28666119}.; FUNCTION: [Isoform 2]: (Microbial infection) Erythrocyte receptor for P.falciparum RH5 which is essential for erythrocyte invasion by the merozoite stage of P.falciparum isolates 3D7, Dd2, 7G8 and HB3 (PubMed:22080952, PubMed:26195724). Binding of P.falciparum RH5 results in BSG dimerization which triggers an increase in intracellular Ca(2+) in the erythrocyte (PubMed:28409866). This essential step leads to a rearrangement of the erythrocyte cytoskeleton required for the merozoite invasion (PubMed:28409866). {ECO:0000269|PubMed:22080952, ECO:0000269|PubMed:26195724, ECO:0000269|PubMed:28409866}.; FUNCTION: [Isoform 2]: (Microbial infection) Can facilitate human SARS coronavirus (SARS-CoV-1) infection via its interaction with virus-associated PPIA/CYPA. {ECO:0000269|PubMed:15688292}.; FUNCTION: [Isoform 2]: (Microbial infection) Can facilitate HIV-1 infection via its interaction with virus-associated PPIA/CYPA. {ECO:0000269|PubMed:11353871}.; FUNCTION: [Isoform 2]: (Microbial infection) First described as a receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), it is not required for SARS-CoV-2 infection. {ECO:0000269|PubMed:33432067, ECO:0000303|PubMed:32307653}.; FUNCTION: [Isoform 2]: (Microbial infection) Acts as a receptor for measles virus. {ECO:0000269|PubMed:20147391}.; FUNCTION: [Isoform 2]: (Microbial infection) Promotes entry of pentamer-expressing human cytomegalovirus (HCMV) into epithelial and endothelial cells. {ECO:0000269|PubMed:29739904}. |
| Q15418 | RPS6KA1 | S45 | Sugiyama | Ribosomal protein S6 kinase alpha-1 (S6K-alpha-1) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (p90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPK-activated protein kinase 1a) (MAPKAP kinase 1a) (MAPKAPK-1a) (Ribosomal S6 kinase 1) (RSK-1) | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1 (PubMed:10679322, PubMed:12213813, PubMed:15117958, PubMed:16223362, PubMed:17360704, PubMed:18722121, PubMed:26158630, PubMed:35772404, PubMed:9430688). In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes (PubMed:18508509, PubMed:18813292). In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP (PubMed:12213813, PubMed:16223362). Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity (PubMed:18508509, PubMed:18813292). Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the pre-initiation complex (PubMed:17360704). In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation (PubMed:16763566). Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway (PubMed:15342917). Also involved in feedback regulation of mTORC1 and mTORC2 by phosphorylating DEPTOR (PubMed:22017876). Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function (PubMed:10679322, PubMed:16213824). Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4) (PubMed:11684016). Mediates induction of hepatocyte prolifration by TGFA through phosphorylation of CEBPB (PubMed:18508509, PubMed:18813292). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression (PubMed:18508509, PubMed:18813292). Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630). In response to mTORC1 activation, phosphorylates EIF4B at 'Ser-406' and 'Ser-422' which stimulates bicarbonate cotransporter SLC4A7 mRNA translation, increasing SLC4A7 protein abundance and function (PubMed:35772404). {ECO:0000269|PubMed:10679322, ECO:0000269|PubMed:11684016, ECO:0000269|PubMed:12213813, ECO:0000269|PubMed:15117958, ECO:0000269|PubMed:15342917, ECO:0000269|PubMed:16213824, ECO:0000269|PubMed:16223362, ECO:0000269|PubMed:16763566, ECO:0000269|PubMed:17360704, ECO:0000269|PubMed:18722121, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:35772404, ECO:0000269|PubMed:9430688, ECO:0000303|PubMed:18508509, ECO:0000303|PubMed:18813292}.; FUNCTION: (Microbial infection) Promotes the late transcription and translation of viral lytic genes during Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, when constitutively activated. {ECO:0000269|PubMed:30842327}. |
| Q8IU85 | CAMK1D | S65 | Sugiyama | Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase I delta) (CaM kinase ID) (CaM-KI delta) (CaMKI delta) (CaMKID) (CaMKI-like protein kinase) (CKLiK) | Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta. {ECO:0000269|PubMed:11050006, ECO:0000269|PubMed:15840691, ECO:0000269|PubMed:16324104, ECO:0000269|PubMed:17056143}. |
| P84243 | H3-3A | Y42 | Sugiyama | Histone H3.3 | Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15776021, ECO:0000269|PubMed:16258499}. |
| Q16695 | H3-4 | Y42 | Sugiyama | Histone H3.1t (H3/t) (H3t) (H3/g) (Histone H3.4) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q6NXT2 | H3-5 | Y41 | Sugiyama | Histone H3.3C (Histone H3.5) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Hominid-specific H3.5/H3F3C preferentially colocalizes with euchromatin, and it is associated with actively transcribed genes. {ECO:0000269|PubMed:21274551}. |
| Q71DI3 | H3C15 | Y42 | Sugiyama | Histone H3.2 (H3-clustered histone 13) (H3-clustered histone 14) (H3-clustered histone 15) (Histone H3/m) (Histone H3/o) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
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| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.000028 | 4.553 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.000053 | 4.273 |
| R-HSA-1500620 | Meiosis | 0.000121 | 3.917 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.000180 | 3.746 |
| R-HSA-912446 | Meiotic recombination | 0.000251 | 3.600 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.000383 | 3.417 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.000490 | 3.310 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 0.001239 | 2.907 |
| R-HSA-5334118 | DNA methylation | 0.000800 | 3.097 |
| R-HSA-390522 | Striated Muscle Contraction | 0.001172 | 2.931 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.001258 | 2.900 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 0.000675 | 3.171 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.000783 | 3.106 |
| R-HSA-68875 | Mitotic Prophase | 0.000640 | 3.194 |
| R-HSA-68886 | M Phase | 0.001058 | 2.976 |
| R-HSA-1474165 | Reproduction | 0.000937 | 3.028 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 0.001091 | 2.962 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.001206 | 2.919 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 0.001440 | 2.841 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 0.001538 | 2.813 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 0.002073 | 2.683 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 0.001967 | 2.706 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.001967 | 2.706 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 0.001967 | 2.706 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.001854 | 2.732 |
| R-HSA-9710421 | Defective pyroptosis | 0.002334 | 2.632 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.002742 | 2.562 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.003075 | 2.512 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.003075 | 2.512 |
| R-HSA-211000 | Gene Silencing by RNA | 0.003300 | 2.482 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.003679 | 2.434 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.003851 | 2.414 |
| R-HSA-2559583 | Cellular Senescence | 0.003578 | 2.446 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.003811 | 2.419 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.005201 | 2.284 |
| R-HSA-983189 | Kinesins | 0.005201 | 2.284 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.004946 | 2.306 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.005633 | 2.249 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.006559 | 2.183 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.007571 | 2.121 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.007054 | 2.152 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.007837 | 2.106 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.007837 | 2.106 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.007921 | 2.101 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.007069 | 2.151 |
| R-HSA-418990 | Adherens junctions interactions | 0.007514 | 2.124 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 0.008542 | 2.068 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.009253 | 2.034 |
| R-HSA-3214842 | HDMs demethylate histones | 0.011113 | 1.954 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.010486 | 1.979 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.009858 | 2.006 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.010139 | 1.994 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.011113 | 1.954 |
| R-HSA-977225 | Amyloid fiber formation | 0.010808 | 1.966 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.011810 | 1.928 |
| R-HSA-1640170 | Cell Cycle | 0.011881 | 1.925 |
| R-HSA-5620971 | Pyroptosis | 0.013238 | 1.878 |
| R-HSA-70268 | Pyruvate metabolism | 0.013226 | 1.879 |
| R-HSA-421270 | Cell-cell junction organization | 0.012642 | 1.898 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.013595 | 1.867 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.014735 | 1.832 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.015928 | 1.798 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.017602 | 1.754 |
| R-HSA-1296072 | Voltage gated Potassium channels | 0.021458 | 1.668 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.020290 | 1.693 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.021714 | 1.663 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.021714 | 1.663 |
| R-HSA-70171 | Glycolysis | 0.019370 | 1.713 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.020290 | 1.693 |
| R-HSA-446728 | Cell junction organization | 0.018297 | 1.738 |
| R-HSA-68877 | Mitotic Prometaphase | 0.023354 | 1.632 |
| R-HSA-195721 | Signaling by WNT | 0.023425 | 1.630 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.024206 | 1.616 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.024246 | 1.615 |
| R-HSA-9960525 | CASP5-mediated substrate cleavage | 0.025144 | 1.600 |
| R-HSA-9960519 | CASP4-mediated substrate cleavage | 0.025144 | 1.600 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.025903 | 1.587 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.026307 | 1.580 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.031975 | 1.495 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.029201 | 1.535 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.033179 | 1.479 |
| R-HSA-5693538 | Homology Directed Repair | 0.030213 | 1.520 |
| R-HSA-70326 | Glucose metabolism | 0.029637 | 1.528 |
| R-HSA-1500931 | Cell-Cell communication | 0.028769 | 1.541 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.033429 | 1.476 |
| R-HSA-5619070 | Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) | 0.044808 | 1.349 |
| R-HSA-1221632 | Meiotic synapsis | 0.039028 | 1.409 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.035030 | 1.456 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.035030 | 1.456 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.035030 | 1.456 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.041361 | 1.383 |
| R-HSA-6798695 | Neutrophil degranulation | 0.035364 | 1.451 |
| R-HSA-111457 | Release of apoptotic factors from the mitochondria | 0.039929 | 1.399 |
| R-HSA-199920 | CREB phosphorylation | 0.044808 | 1.349 |
| R-HSA-8951664 | Neddylation | 0.034973 | 1.456 |
| R-HSA-8939211 | ESR-mediated signaling | 0.042595 | 1.371 |
| R-HSA-392499 | Metabolism of proteins | 0.034627 | 1.461 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.046179 | 1.336 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.046500 | 1.333 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.046500 | 1.333 |
| R-HSA-9664407 | Parasite infection | 0.046500 | 1.333 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.047226 | 1.326 |
| R-HSA-72731 | Recycling of eIF2:GDP | 0.049662 | 1.304 |
| R-HSA-426117 | Cation-coupled Chloride cotransporters | 0.049662 | 1.304 |
| R-HSA-1268020 | Mitochondrial protein import | 0.049922 | 1.302 |
| R-HSA-444257 | RSK activation | 0.054493 | 1.264 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.056392 | 1.249 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.057170 | 1.243 |
| R-HSA-69306 | DNA Replication | 0.057170 | 1.243 |
| R-HSA-5218859 | Regulated Necrosis | 0.057720 | 1.239 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.057974 | 1.237 |
| R-HSA-448706 | Interleukin-1 processing | 0.059299 | 1.227 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 0.059299 | 1.227 |
| R-HSA-9610379 | HCMV Late Events | 0.060415 | 1.219 |
| R-HSA-433692 | Proton-coupled monocarboxylate transport | 0.073572 | 1.133 |
| R-HSA-210991 | Basigin interactions | 0.124101 | 0.906 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.154828 | 0.810 |
| R-HSA-171306 | Packaging Of Telomere Ends | 0.154828 | 0.810 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.167669 | 0.776 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.171906 | 0.765 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.171906 | 0.765 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.180317 | 0.744 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.180317 | 0.744 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.184490 | 0.734 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.159130 | 0.798 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.180317 | 0.744 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.140075 | 0.854 |
| R-HSA-9609690 | HCMV Early Events | 0.097317 | 1.012 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 0.119622 | 0.922 |
| R-HSA-3214847 | HATs acetylate histones | 0.108475 | 0.965 |
| R-HSA-4839726 | Chromatin organization | 0.157975 | 0.801 |
| R-HSA-192814 | vRNA Synthesis | 0.068838 | 1.162 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 0.073572 | 1.133 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.103620 | 0.985 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.184490 | 0.734 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.184490 | 0.734 |
| R-HSA-8964058 | HDL remodeling | 0.115121 | 0.939 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.082968 | 1.081 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.066298 | 1.179 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 0.141792 | 0.848 |
| R-HSA-9609646 | HCMV Infection | 0.159193 | 0.798 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.150505 | 0.822 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 0.137403 | 0.862 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 0.115121 | 0.939 |
| R-HSA-9754560 | SARS-CoV-2 modulates autophagy | 0.068838 | 1.162 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.176122 | 0.754 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.130834 | 0.883 |
| R-HSA-9706369 | Negative regulation of FLT3 | 0.096887 | 1.014 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.065911 | 1.181 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.076051 | 1.119 |
| R-HSA-157579 | Telomere Maintenance | 0.105232 | 0.978 |
| R-HSA-198753 | ERK/MAPK targets | 0.124101 | 0.906 |
| R-HSA-73886 | Chromosome Maintenance | 0.150996 | 0.821 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.087631 | 1.057 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.163410 | 0.787 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.074232 | 1.129 |
| R-HSA-9686114 | Non-canonical inflammasome activation | 0.087631 | 1.057 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.075923 | 1.120 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.101420 | 0.994 |
| R-HSA-73884 | Base Excision Repair | 0.090991 | 1.041 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.169042 | 0.772 |
| R-HSA-68882 | Mitotic Anaphase | 0.119606 | 0.922 |
| R-HSA-373760 | L1CAM interactions | 0.142234 | 0.847 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.120712 | 0.918 |
| R-HSA-9658195 | Leishmania infection | 0.068020 | 1.167 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.068020 | 1.167 |
| R-HSA-69481 | G2/M Checkpoints | 0.163437 | 0.787 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.166563 | 0.778 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.131782 | 0.880 |
| R-HSA-397014 | Muscle contraction | 0.115222 | 0.938 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.176122 | 0.754 |
| R-HSA-199991 | Membrane Trafficking | 0.125974 | 0.900 |
| R-HSA-597592 | Post-translational protein modification | 0.144156 | 0.841 |
| R-HSA-1296071 | Potassium Channels | 0.103620 | 0.985 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.112752 | 0.948 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.135308 | 0.869 |
| R-HSA-109582 | Hemostasis | 0.115889 | 0.936 |
| R-HSA-2262752 | Cellular responses to stress | 0.158727 | 0.799 |
| R-HSA-111471 | Apoptotic factor-mediated response | 0.110597 | 0.956 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.110597 | 0.956 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.132991 | 0.876 |
| R-HSA-168256 | Immune System | 0.108651 | 0.964 |
| R-HSA-157118 | Signaling by NOTCH | 0.147149 | 0.832 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.140495 | 0.852 |
| R-HSA-194138 | Signaling by VEGF | 0.159863 | 0.796 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.188643 | 0.724 |
| R-HSA-5205647 | Mitophagy | 0.188643 | 0.724 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.188643 | 0.724 |
| R-HSA-5686938 | Regulation of TLR by endogenous ligand | 0.188643 | 0.724 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.188643 | 0.724 |
| R-HSA-1632852 | Macroautophagy | 0.192501 | 0.716 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.192775 | 0.715 |
| R-HSA-381042 | PERK regulates gene expression | 0.192775 | 0.715 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.195694 | 0.708 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.196886 | 0.706 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.199586 | 0.700 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.200976 | 0.697 |
| R-HSA-4641258 | Degradation of DVL | 0.200976 | 0.697 |
| R-HSA-110331 | Cleavage of the damaged purine | 0.200976 | 0.697 |
| R-HSA-73927 | Depurination | 0.205046 | 0.688 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.205046 | 0.688 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.205046 | 0.688 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.205428 | 0.687 |
| R-HSA-69242 | S Phase | 0.207283 | 0.683 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.209095 | 0.680 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.209095 | 0.680 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.213124 | 0.671 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.213124 | 0.671 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.213124 | 0.671 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.213124 | 0.671 |
| R-HSA-9854311 | Maturation of TCA enzymes and regulation of TCA cycle | 0.213124 | 0.671 |
| R-HSA-9609507 | Protein localization | 0.216585 | 0.664 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.217132 | 0.663 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.217132 | 0.663 |
| R-HSA-9607240 | FLT3 Signaling | 0.217132 | 0.663 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.218450 | 0.661 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.220317 | 0.657 |
| R-HSA-9612973 | Autophagy | 0.222185 | 0.653 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 0.225089 | 0.648 |
| R-HSA-73928 | Depyrimidination | 0.225089 | 0.648 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.229037 | 0.640 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.236874 | 0.625 |
| R-HSA-112316 | Neuronal System | 0.238598 | 0.622 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.240763 | 0.618 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.240763 | 0.618 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 0.240763 | 0.618 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.240763 | 0.618 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.240763 | 0.618 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.241861 | 0.616 |
| R-HSA-5619102 | SLC transporter disorders | 0.242811 | 0.615 |
| R-HSA-437239 | Recycling pathway of L1 | 0.244633 | 0.611 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.246907 | 0.607 |
| R-HSA-168249 | Innate Immune System | 0.248180 | 0.605 |
| R-HSA-8963899 | Plasma lipoprotein remodeling | 0.248483 | 0.605 |
| R-HSA-382551 | Transport of small molecules | 0.248517 | 0.605 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.254393 | 0.594 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.255986 | 0.592 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.263690 | 0.579 |
| R-HSA-168255 | Influenza Infection | 0.267294 | 0.573 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.267444 | 0.573 |
| R-HSA-72649 | Translation initiation complex formation | 0.271179 | 0.567 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 0.271179 | 0.567 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.274895 | 0.561 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.278593 | 0.555 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.278593 | 0.555 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.278593 | 0.555 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.282272 | 0.549 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.285932 | 0.544 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.285932 | 0.544 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.289574 | 0.538 |
| R-HSA-191859 | snRNP Assembly | 0.289574 | 0.538 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.289902 | 0.538 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.293198 | 0.533 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.295546 | 0.529 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.296803 | 0.528 |
| R-HSA-450294 | MAP kinase activation | 0.296803 | 0.528 |
| R-HSA-1280218 | Adaptive Immune System | 0.300382 | 0.522 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.300390 | 0.522 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.300390 | 0.522 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.303959 | 0.517 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.303959 | 0.517 |
| R-HSA-73894 | DNA Repair | 0.305524 | 0.515 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.307510 | 0.512 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.310565 | 0.508 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.314559 | 0.502 |
| R-HSA-72172 | mRNA Splicing | 0.316182 | 0.500 |
| R-HSA-5357801 | Programmed Cell Death | 0.318052 | 0.498 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.321537 | 0.493 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.323468 | 0.490 |
| R-HSA-448424 | Interleukin-17 signaling | 0.328444 | 0.484 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.331872 | 0.479 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.335282 | 0.475 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.335282 | 0.475 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.338675 | 0.470 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.338675 | 0.470 |
| R-HSA-9749641 | Aspirin ADME | 0.338675 | 0.470 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.339001 | 0.470 |
| R-HSA-380287 | Centrosome maturation | 0.345411 | 0.462 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 0.345411 | 0.462 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.345411 | 0.462 |
| R-HSA-9955298 | SLC-mediated transport of organic anions | 0.355387 | 0.449 |
| R-HSA-216083 | Integrin cell surface interactions | 0.355387 | 0.449 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.360693 | 0.443 |
| R-HSA-9833482 | PKR-mediated signaling | 0.361954 | 0.441 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.368454 | 0.434 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.374890 | 0.426 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.374890 | 0.426 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.378083 | 0.422 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.381261 | 0.419 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.381261 | 0.419 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.387567 | 0.412 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.390697 | 0.408 |
| R-HSA-9663891 | Selective autophagy | 0.390697 | 0.408 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.395196 | 0.403 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.396908 | 0.401 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.404813 | 0.393 |
| R-HSA-391251 | Protein folding | 0.406108 | 0.391 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.406108 | 0.391 |
| R-HSA-5688426 | Deubiquitination | 0.409480 | 0.388 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.412165 | 0.385 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.418160 | 0.379 |
| R-HSA-449147 | Signaling by Interleukins | 0.418653 | 0.378 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.424095 | 0.373 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.427040 | 0.370 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.427040 | 0.370 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.427040 | 0.370 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.432885 | 0.364 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.432885 | 0.364 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.438171 | 0.358 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.438672 | 0.358 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.438672 | 0.358 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.444400 | 0.352 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.450070 | 0.347 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.450070 | 0.347 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.455683 | 0.341 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.455683 | 0.341 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.458469 | 0.339 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.458469 | 0.339 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.458469 | 0.339 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.461240 | 0.336 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.461240 | 0.336 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.463997 | 0.333 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.463997 | 0.333 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.469470 | 0.328 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.472186 | 0.326 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.480251 | 0.319 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.485559 | 0.314 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.485559 | 0.314 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.493422 | 0.307 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.493422 | 0.307 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.493422 | 0.307 |
| R-HSA-3371556 | Cellular response to heat stress | 0.498598 | 0.302 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.501166 | 0.300 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.501166 | 0.300 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.503722 | 0.298 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.506264 | 0.296 |
| R-HSA-5663205 | Infectious disease | 0.512113 | 0.291 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.518784 | 0.285 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.530991 | 0.275 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.549888 | 0.260 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.559053 | 0.253 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.559053 | 0.253 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.563186 | 0.249 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.572455 | 0.242 |
| R-HSA-166520 | Signaling by NTRKs | 0.572455 | 0.242 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.581165 | 0.236 |
| R-HSA-162587 | HIV Life Cycle | 0.591807 | 0.228 |
| R-HSA-9711097 | Cellular response to starvation | 0.593903 | 0.226 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.598064 | 0.223 |
| R-HSA-109581 | Apoptosis | 0.602182 | 0.220 |
| R-HSA-913531 | Interferon Signaling | 0.612801 | 0.213 |
| R-HSA-72306 | tRNA processing | 0.620204 | 0.207 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.629866 | 0.201 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.631430 | 0.200 |
| R-HSA-69275 | G2/M Transition | 0.650274 | 0.187 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.653864 | 0.185 |
| R-HSA-983712 | Ion channel transport | 0.655645 | 0.183 |
| R-HSA-5617833 | Cilium Assembly | 0.657417 | 0.182 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.662975 | 0.179 |
| R-HSA-72766 | Translation | 0.671417 | 0.173 |
| R-HSA-428157 | Sphingolipid metabolism | 0.676324 | 0.170 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.695775 | 0.158 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.697343 | 0.157 |
| R-HSA-9824446 | Viral Infection Pathways | 0.703399 | 0.153 |
| R-HSA-9748784 | Drug ADME | 0.705063 | 0.152 |
| R-HSA-162906 | HIV Infection | 0.718472 | 0.144 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.732666 | 0.135 |
| R-HSA-416476 | G alpha (q) signalling events | 0.767553 | 0.115 |
| R-HSA-422475 | Axon guidance | 0.787960 | 0.103 |
| R-HSA-9679506 | SARS-CoV Infections | 0.796103 | 0.099 |
| R-HSA-9675108 | Nervous system development | 0.816742 | 0.088 |
| R-HSA-8953854 | Metabolism of RNA | 0.817689 | 0.087 |
| R-HSA-212436 | Generic Transcription Pathway | 0.823650 | 0.084 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.826208 | 0.083 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.828899 | 0.081 |
| R-HSA-1474244 | Extracellular matrix organization | 0.835877 | 0.078 |
| R-HSA-162582 | Signal Transduction | 0.874077 | 0.058 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.881107 | 0.055 |
| R-HSA-1643685 | Disease | 0.881190 | 0.055 |
| R-HSA-74160 | Gene expression (Transcription) | 0.893832 | 0.049 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.937706 | 0.028 |
| R-HSA-1266738 | Developmental Biology | 0.977816 | 0.010 |
| R-HSA-388396 | GPCR downstream signalling | 0.984262 | 0.007 |
| R-HSA-372790 | Signaling by GPCR | 0.989923 | 0.004 |
| R-HSA-556833 | Metabolism of lipids | 0.999687 | 0.000 |
| R-HSA-1430728 | Metabolism | 0.999970 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
AURC |
0.754 | 0.185 | -2 | 0.581 |
NDR2 |
0.749 | 0.148 | -3 | 0.792 |
AMPKA1 |
0.749 | 0.242 | -3 | 0.805 |
WNK1 |
0.748 | 0.260 | -2 | 0.755 |
PRKX |
0.748 | 0.204 | -3 | 0.745 |
AMPKA2 |
0.747 | 0.229 | -3 | 0.802 |
PRKD2 |
0.746 | 0.163 | -3 | 0.784 |
PKACG |
0.746 | 0.164 | -2 | 0.637 |
RSK2 |
0.745 | 0.140 | -3 | 0.731 |
NDR1 |
0.745 | 0.183 | -3 | 0.785 |
MNK2 |
0.743 | 0.193 | -2 | 0.669 |
MST4 |
0.742 | 0.173 | 2 | 0.707 |
AURB |
0.742 | 0.153 | -2 | 0.581 |
PIM3 |
0.742 | 0.114 | -3 | 0.755 |
CLK3 |
0.742 | 0.145 | 1 | 0.644 |
PKG2 |
0.742 | 0.162 | -2 | 0.586 |
PKN3 |
0.741 | 0.163 | -3 | 0.753 |
CAMK1B |
0.741 | 0.161 | -3 | 0.763 |
PIM1 |
0.741 | 0.164 | -3 | 0.738 |
PKACB |
0.740 | 0.165 | -2 | 0.601 |
RSK4 |
0.739 | 0.156 | -3 | 0.726 |
CDC7 |
0.739 | 0.063 | 1 | 0.737 |
TSSK1 |
0.739 | 0.190 | -3 | 0.812 |
CAMK2D |
0.739 | 0.122 | -3 | 0.776 |
MNK1 |
0.738 | 0.202 | -2 | 0.653 |
P90RSK |
0.738 | 0.112 | -3 | 0.714 |
MAPKAPK3 |
0.738 | 0.139 | -3 | 0.760 |
PKN2 |
0.738 | 0.161 | -3 | 0.779 |
MARK4 |
0.738 | 0.118 | 4 | 0.832 |
MOS |
0.737 | 0.145 | 1 | 0.740 |
P70S6KB |
0.737 | 0.150 | -3 | 0.750 |
RSK3 |
0.737 | 0.110 | -3 | 0.708 |
CAMK4 |
0.736 | 0.167 | -3 | 0.790 |
LATS2 |
0.736 | 0.095 | -5 | 0.651 |
MELK |
0.736 | 0.186 | -3 | 0.794 |
PRKD1 |
0.736 | 0.084 | -3 | 0.766 |
COT |
0.736 | 0.044 | 2 | 0.695 |
SKMLCK |
0.736 | 0.131 | -2 | 0.732 |
PAK6 |
0.736 | 0.158 | -2 | 0.599 |
BRSK2 |
0.735 | 0.156 | -3 | 0.798 |
NUAK2 |
0.735 | 0.114 | -3 | 0.791 |
SRPK1 |
0.734 | 0.084 | -3 | 0.678 |
MAPKAPK2 |
0.733 | 0.112 | -3 | 0.722 |
RIPK3 |
0.733 | 0.083 | 3 | 0.630 |
RAF1 |
0.733 | 0.042 | 1 | 0.743 |
CAMK2B |
0.733 | 0.124 | 2 | 0.667 |
SGK3 |
0.733 | 0.167 | -3 | 0.756 |
TSSK2 |
0.733 | 0.144 | -5 | 0.759 |
SIK |
0.732 | 0.119 | -3 | 0.745 |
CLK1 |
0.732 | 0.141 | -3 | 0.742 |
PHKG1 |
0.732 | 0.151 | -3 | 0.787 |
PRPK |
0.732 | 0.030 | -1 | 0.652 |
BRSK1 |
0.732 | 0.124 | -3 | 0.765 |
MTOR |
0.731 | -0.005 | 1 | 0.688 |
CAMLCK |
0.731 | 0.114 | -2 | 0.700 |
PDHK4 |
0.731 | -0.050 | 1 | 0.734 |
MYLK4 |
0.731 | 0.128 | -2 | 0.663 |
CLK4 |
0.731 | 0.125 | -3 | 0.727 |
NIK |
0.731 | 0.166 | -3 | 0.771 |
CAMK2G |
0.731 | 0.031 | 2 | 0.653 |
IKKB |
0.730 | -0.051 | -2 | 0.549 |
PKACA |
0.730 | 0.141 | -2 | 0.559 |
QIK |
0.730 | 0.103 | -3 | 0.784 |
PKCD |
0.730 | 0.117 | 2 | 0.637 |
QSK |
0.730 | 0.100 | 4 | 0.809 |
PRKD3 |
0.730 | 0.119 | -3 | 0.731 |
HIPK4 |
0.729 | 0.052 | 1 | 0.640 |
PAK1 |
0.729 | 0.115 | -2 | 0.665 |
GRK1 |
0.729 | 0.075 | -2 | 0.599 |
DAPK2 |
0.728 | 0.103 | -3 | 0.765 |
TBK1 |
0.728 | 0.006 | 1 | 0.696 |
MARK3 |
0.728 | 0.121 | 4 | 0.791 |
CHAK2 |
0.727 | 0.062 | -1 | 0.671 |
CLK2 |
0.727 | 0.139 | -3 | 0.710 |
CDKL1 |
0.727 | 0.039 | -3 | 0.703 |
NLK |
0.727 | 0.004 | 1 | 0.676 |
CDKL5 |
0.727 | 0.045 | -3 | 0.706 |
AKT2 |
0.727 | 0.127 | -3 | 0.687 |
CAMK1G |
0.726 | 0.142 | -3 | 0.724 |
PAK3 |
0.726 | 0.084 | -2 | 0.660 |
DCAMKL1 |
0.726 | 0.210 | -3 | 0.788 |
WNK3 |
0.726 | 0.045 | 1 | 0.689 |
CAMK2A |
0.726 | 0.093 | 2 | 0.642 |
NUAK1 |
0.726 | 0.086 | -3 | 0.775 |
PIM2 |
0.725 | 0.142 | -3 | 0.725 |
SRPK2 |
0.725 | 0.068 | -3 | 0.624 |
MSK1 |
0.725 | 0.084 | -3 | 0.689 |
PDHK1 |
0.725 | -0.050 | 1 | 0.738 |
PKCA |
0.725 | 0.088 | 2 | 0.591 |
TGFBR2 |
0.725 | -0.017 | -2 | 0.624 |
CAMK1D |
0.724 | 0.168 | -3 | 0.735 |
AURA |
0.724 | 0.089 | -2 | 0.558 |
RIPK1 |
0.724 | 0.031 | 1 | 0.703 |
ATR |
0.723 | -0.039 | 1 | 0.676 |
IKKE |
0.722 | -0.040 | 1 | 0.695 |
AKT1 |
0.722 | 0.139 | -3 | 0.725 |
NIM1 |
0.722 | 0.029 | 3 | 0.642 |
ICK |
0.722 | 0.036 | -3 | 0.740 |
SSTK |
0.722 | 0.154 | 4 | 0.810 |
PKCG |
0.721 | 0.078 | 2 | 0.575 |
MSK2 |
0.721 | 0.048 | -3 | 0.677 |
BCKDK |
0.721 | -0.041 | -1 | 0.555 |
PHKG2 |
0.721 | 0.162 | -3 | 0.795 |
PKCH |
0.721 | 0.090 | 2 | 0.572 |
ULK2 |
0.721 | -0.092 | 2 | 0.643 |
PAK2 |
0.721 | 0.076 | -2 | 0.653 |
NEK6 |
0.721 | -0.023 | -2 | 0.687 |
DCAMKL2 |
0.720 | 0.172 | -3 | 0.801 |
GCN2 |
0.720 | -0.087 | 2 | 0.654 |
MARK2 |
0.720 | 0.080 | 4 | 0.763 |
BMPR2 |
0.720 | -0.120 | -2 | 0.679 |
DSTYK |
0.719 | -0.098 | 2 | 0.723 |
LATS1 |
0.719 | 0.111 | -3 | 0.777 |
MARK1 |
0.719 | 0.075 | 4 | 0.806 |
PKCZ |
0.718 | 0.069 | 2 | 0.627 |
PKCB |
0.718 | 0.069 | 2 | 0.580 |
NEK7 |
0.718 | -0.087 | -3 | 0.690 |
KIS |
0.718 | 0.006 | 1 | 0.553 |
HUNK |
0.718 | -0.083 | 2 | 0.627 |
MASTL |
0.718 | -0.059 | -2 | 0.642 |
PAK5 |
0.717 | 0.111 | -2 | 0.555 |
CHK1 |
0.717 | 0.113 | -3 | 0.778 |
P70S6K |
0.716 | 0.098 | -3 | 0.683 |
ANKRD3 |
0.716 | 0.001 | 1 | 0.744 |
WNK4 |
0.715 | 0.140 | -2 | 0.770 |
MRCKA |
0.715 | 0.197 | -3 | 0.757 |
FAM20C |
0.714 | 0.093 | 2 | 0.637 |
SNRK |
0.714 | 0.023 | 2 | 0.523 |
HIPK1 |
0.714 | 0.058 | 1 | 0.583 |
SGK1 |
0.714 | 0.132 | -3 | 0.622 |
PKCE |
0.713 | 0.119 | 2 | 0.571 |
MLK1 |
0.713 | -0.093 | 2 | 0.653 |
CDK7 |
0.713 | 0.010 | 1 | 0.523 |
PAK4 |
0.713 | 0.094 | -2 | 0.551 |
SRPK3 |
0.713 | 0.016 | -3 | 0.633 |
MRCKB |
0.712 | 0.175 | -3 | 0.746 |
AKT3 |
0.712 | 0.121 | -3 | 0.642 |
ERK5 |
0.712 | -0.070 | 1 | 0.645 |
GRK5 |
0.712 | -0.144 | -3 | 0.651 |
ROCK2 |
0.712 | 0.211 | -3 | 0.778 |
CAMK1A |
0.711 | 0.143 | -3 | 0.686 |
PKCI |
0.711 | 0.087 | 2 | 0.586 |
PKCT |
0.711 | 0.076 | 2 | 0.588 |
CHAK1 |
0.710 | 0.002 | 2 | 0.676 |
MAPKAPK5 |
0.710 | -0.002 | -3 | 0.652 |
HIPK2 |
0.710 | 0.038 | 1 | 0.498 |
DYRK2 |
0.710 | 0.002 | 1 | 0.583 |
IRE1 |
0.710 | -0.030 | 1 | 0.631 |
ULK1 |
0.710 | -0.139 | -3 | 0.633 |
MLK2 |
0.709 | -0.045 | 2 | 0.694 |
NEK2 |
0.709 | -0.017 | 2 | 0.655 |
PKG1 |
0.709 | 0.095 | -2 | 0.551 |
NEK9 |
0.709 | -0.093 | 2 | 0.681 |
SMMLCK |
0.709 | 0.078 | -3 | 0.748 |
DAPK3 |
0.709 | 0.137 | -3 | 0.764 |
PKR |
0.709 | 0.029 | 1 | 0.684 |
PKN1 |
0.708 | 0.111 | -3 | 0.720 |
DLK |
0.708 | -0.102 | 1 | 0.697 |
ALK4 |
0.708 | -0.015 | -2 | 0.653 |
TTBK2 |
0.708 | -0.100 | 2 | 0.540 |
IKKA |
0.708 | -0.091 | -2 | 0.515 |
DNAPK |
0.708 | 0.011 | 1 | 0.647 |
MST3 |
0.707 | 0.103 | 2 | 0.664 |
DRAK1 |
0.706 | 0.023 | 1 | 0.681 |
DMPK1 |
0.705 | 0.206 | -3 | 0.769 |
CHK2 |
0.705 | 0.092 | -3 | 0.667 |
BMPR1B |
0.705 | 0.004 | 1 | 0.679 |
GRK6 |
0.705 | -0.106 | 1 | 0.730 |
IRAK4 |
0.705 | 0.039 | 1 | 0.654 |
CDK10 |
0.704 | 0.056 | 1 | 0.491 |
VRK2 |
0.704 | -0.024 | 1 | 0.719 |
CDK18 |
0.704 | 0.008 | 1 | 0.460 |
DAPK1 |
0.703 | 0.106 | -3 | 0.740 |
HIPK3 |
0.703 | 0.015 | 1 | 0.598 |
ATM |
0.703 | -0.066 | 1 | 0.651 |
TGFBR1 |
0.703 | -0.019 | -2 | 0.627 |
PLK4 |
0.703 | 0.004 | 2 | 0.477 |
GRK7 |
0.703 | -0.013 | 1 | 0.676 |
MEK1 |
0.703 | -0.086 | 2 | 0.681 |
GRK4 |
0.703 | -0.144 | -2 | 0.639 |
ALK2 |
0.702 | 0.004 | -2 | 0.636 |
CRIK |
0.702 | 0.155 | -3 | 0.715 |
PLK1 |
0.702 | -0.072 | -2 | 0.594 |
DYRK3 |
0.702 | 0.042 | 1 | 0.599 |
SMG1 |
0.701 | -0.068 | 1 | 0.627 |
MLK3 |
0.701 | -0.072 | 2 | 0.600 |
IRE2 |
0.700 | -0.048 | 2 | 0.600 |
CDK1 |
0.700 | -0.004 | 1 | 0.491 |
PASK |
0.700 | 0.057 | -3 | 0.759 |
YSK4 |
0.699 | -0.089 | 1 | 0.676 |
CDK8 |
0.699 | -0.057 | 1 | 0.512 |
CDK5 |
0.699 | -0.011 | 1 | 0.529 |
PDK1 |
0.699 | 0.101 | 1 | 0.773 |
DYRK1A |
0.698 | 0.003 | 1 | 0.590 |
ROCK1 |
0.698 | 0.168 | -3 | 0.754 |
ACVR2B |
0.698 | -0.030 | -2 | 0.606 |
PERK |
0.698 | -0.061 | -2 | 0.637 |
ACVR2A |
0.698 | -0.059 | -2 | 0.599 |
CDK9 |
0.697 | -0.031 | 1 | 0.520 |
CDK14 |
0.696 | 0.012 | 1 | 0.505 |
TAO3 |
0.696 | 0.058 | 1 | 0.673 |
CDK13 |
0.696 | -0.040 | 1 | 0.509 |
HRI |
0.695 | -0.089 | -2 | 0.657 |
BRAF |
0.695 | -0.048 | -4 | 0.680 |
CDK19 |
0.695 | -0.055 | 1 | 0.478 |
BUB1 |
0.695 | 0.106 | -5 | 0.731 |
MOK |
0.695 | 0.071 | 1 | 0.599 |
CK1E |
0.694 | -0.039 | -3 | 0.346 |
MEK5 |
0.694 | -0.098 | 2 | 0.674 |
CDK17 |
0.694 | -0.012 | 1 | 0.425 |
DYRK1B |
0.694 | 0.009 | 1 | 0.516 |
MPSK1 |
0.694 | 0.003 | 1 | 0.597 |
NEK5 |
0.693 | -0.020 | 1 | 0.681 |
CDK12 |
0.693 | -0.033 | 1 | 0.493 |
ZAK |
0.693 | -0.058 | 1 | 0.679 |
CDK3 |
0.693 | 0.017 | 1 | 0.442 |
TLK2 |
0.693 | -0.091 | 1 | 0.656 |
SBK |
0.692 | 0.077 | -3 | 0.608 |
MEKK3 |
0.692 | -0.097 | 1 | 0.681 |
TTBK1 |
0.692 | -0.087 | 2 | 0.460 |
HPK1 |
0.692 | 0.082 | 1 | 0.692 |
PLK3 |
0.692 | -0.081 | 2 | 0.593 |
JNK2 |
0.691 | -0.017 | 1 | 0.499 |
CDK2 |
0.691 | -0.036 | 1 | 0.567 |
MAK |
0.691 | 0.039 | -2 | 0.521 |
BMPR1A |
0.691 | -0.001 | 1 | 0.676 |
NEK11 |
0.691 | -0.014 | 1 | 0.714 |
GSK3B |
0.691 | 0.019 | 4 | 0.464 |
DYRK4 |
0.691 | -0.011 | 1 | 0.508 |
P38A |
0.690 | -0.040 | 1 | 0.557 |
PRP4 |
0.690 | -0.028 | -3 | 0.621 |
TAO2 |
0.690 | 0.038 | 2 | 0.689 |
LOK |
0.689 | 0.067 | -2 | 0.590 |
MEKK1 |
0.689 | -0.118 | 1 | 0.684 |
LKB1 |
0.689 | 0.002 | -3 | 0.738 |
GRK2 |
0.688 | -0.101 | -2 | 0.541 |
CDK16 |
0.688 | 0.024 | 1 | 0.439 |
KHS2 |
0.688 | 0.101 | 1 | 0.692 |
MLK4 |
0.688 | -0.137 | 2 | 0.585 |
GCK |
0.688 | 0.048 | 1 | 0.680 |
CK1A2 |
0.688 | -0.039 | -3 | 0.314 |
GAK |
0.687 | 0.016 | 1 | 0.649 |
CK1D |
0.687 | -0.045 | -3 | 0.309 |
IRAK1 |
0.687 | -0.122 | -1 | 0.588 |
KHS1 |
0.687 | 0.094 | 1 | 0.694 |
P38B |
0.687 | -0.043 | 1 | 0.514 |
GSK3A |
0.686 | 0.020 | 4 | 0.470 |
JNK3 |
0.685 | -0.053 | 1 | 0.533 |
PDHK3_TYR |
0.685 | 0.101 | 4 | 0.833 |
MEKK2 |
0.685 | -0.125 | 2 | 0.662 |
ERK1 |
0.685 | -0.055 | 1 | 0.504 |
P38G |
0.685 | -0.027 | 1 | 0.423 |
TESK1_TYR |
0.684 | 0.125 | 3 | 0.718 |
MAP3K15 |
0.683 | 0.002 | 1 | 0.675 |
LIMK2_TYR |
0.683 | 0.145 | -3 | 0.787 |
CK1G1 |
0.683 | -0.079 | -3 | 0.321 |
NEK8 |
0.683 | -0.098 | 2 | 0.648 |
NEK4 |
0.682 | -0.040 | 1 | 0.667 |
LRRK2 |
0.682 | -0.022 | 2 | 0.670 |
STK33 |
0.682 | -0.052 | 2 | 0.480 |
VRK1 |
0.681 | 0.053 | 2 | 0.652 |
TNIK |
0.681 | 0.020 | 3 | 0.698 |
PKMYT1_TYR |
0.680 | 0.048 | 3 | 0.693 |
NEK1 |
0.680 | 0.012 | 1 | 0.671 |
TLK1 |
0.680 | -0.142 | -2 | 0.642 |
ERK2 |
0.680 | -0.078 | 1 | 0.526 |
SLK |
0.680 | -0.004 | -2 | 0.530 |
EEF2K |
0.680 | -0.045 | 3 | 0.672 |
RIPK2 |
0.679 | -0.095 | 1 | 0.680 |
HASPIN |
0.679 | 0.036 | -1 | 0.579 |
HGK |
0.679 | -0.030 | 3 | 0.695 |
MINK |
0.679 | -0.018 | 1 | 0.683 |
MAP2K7_TYR |
0.678 | 0.005 | 2 | 0.700 |
MEKK6 |
0.678 | -0.046 | 1 | 0.637 |
GRK3 |
0.678 | -0.096 | -2 | 0.522 |
PDHK4_TYR |
0.678 | 0.053 | 2 | 0.722 |
PBK |
0.677 | 0.011 | 1 | 0.569 |
YSK1 |
0.676 | 0.003 | 2 | 0.659 |
CAMKK2 |
0.676 | -0.136 | -2 | 0.533 |
ERK7 |
0.675 | -0.043 | 2 | 0.406 |
TAK1 |
0.675 | -0.081 | 1 | 0.711 |
PINK1 |
0.675 | -0.231 | 1 | 0.636 |
MAP2K4_TYR |
0.675 | -0.061 | -1 | 0.658 |
BMPR2_TYR |
0.674 | 0.045 | -1 | 0.711 |
PINK1_TYR |
0.674 | -0.027 | 1 | 0.701 |
CAMKK1 |
0.674 | -0.188 | -2 | 0.543 |
RET |
0.674 | 0.047 | 1 | 0.699 |
NEK3 |
0.673 | -0.032 | 1 | 0.651 |
MEK2 |
0.671 | -0.124 | 2 | 0.666 |
CDK6 |
0.671 | -0.036 | 1 | 0.487 |
LIMK1_TYR |
0.671 | -0.021 | 2 | 0.705 |
TYK2 |
0.671 | -0.024 | 1 | 0.707 |
CDK4 |
0.671 | -0.035 | 1 | 0.478 |
MST2 |
0.670 | -0.118 | 1 | 0.693 |
DDR1 |
0.670 | 0.022 | 4 | 0.791 |
PDHK1_TYR |
0.670 | -0.050 | -1 | 0.695 |
EPHA6 |
0.669 | 0.043 | -1 | 0.715 |
MST1R |
0.669 | 0.009 | 3 | 0.650 |
MST1 |
0.669 | -0.071 | 1 | 0.678 |
MAP2K6_TYR |
0.669 | -0.104 | -1 | 0.663 |
CK2A2 |
0.669 | -0.063 | 1 | 0.578 |
TNK2 |
0.669 | 0.015 | 3 | 0.607 |
P38D |
0.668 | -0.054 | 1 | 0.434 |
NEK10_TYR |
0.668 | 0.064 | 1 | 0.616 |
JAK2 |
0.667 | -0.033 | 1 | 0.704 |
TNK1 |
0.666 | 0.038 | 3 | 0.623 |
ROS1 |
0.666 | -0.039 | 3 | 0.637 |
PLK2 |
0.666 | -0.086 | -3 | 0.517 |
EPHB4 |
0.665 | -0.018 | -1 | 0.654 |
TAO1 |
0.664 | 0.016 | 1 | 0.638 |
JAK1 |
0.664 | 0.019 | 1 | 0.685 |
ABL2 |
0.664 | -0.007 | -1 | 0.650 |
CK2A1 |
0.664 | -0.060 | 1 | 0.553 |
TXK |
0.663 | 0.036 | 1 | 0.661 |
TYRO3 |
0.663 | -0.065 | 3 | 0.647 |
JAK3 |
0.662 | -0.004 | 1 | 0.689 |
HCK |
0.662 | 0.009 | -1 | 0.720 |
YES1 |
0.661 | -0.036 | -1 | 0.704 |
YANK3 |
0.660 | -0.055 | 2 | 0.286 |
LCK |
0.660 | 0.040 | -1 | 0.736 |
EPHB1 |
0.660 | -0.018 | 1 | 0.727 |
BLK |
0.660 | 0.051 | -1 | 0.741 |
CSF1R |
0.660 | -0.071 | 3 | 0.621 |
JNK1 |
0.659 | -0.078 | 1 | 0.488 |
ABL1 |
0.659 | -0.025 | -1 | 0.649 |
AXL |
0.659 | -0.024 | 3 | 0.628 |
ASK1 |
0.658 | -0.051 | 1 | 0.676 |
FGFR2 |
0.658 | -0.051 | 3 | 0.644 |
MYO3B |
0.658 | -0.038 | 2 | 0.675 |
FGR |
0.658 | -0.076 | 1 | 0.664 |
SRMS |
0.658 | -0.049 | 1 | 0.723 |
TTK |
0.658 | -0.080 | -2 | 0.629 |
EPHA4 |
0.658 | -0.021 | 2 | 0.601 |
EPHB3 |
0.658 | -0.012 | -1 | 0.648 |
BIKE |
0.657 | -0.031 | 1 | 0.539 |
TNNI3K_TYR |
0.657 | -0.029 | 1 | 0.664 |
KDR |
0.657 | -0.024 | 3 | 0.595 |
FER |
0.657 | -0.109 | 1 | 0.724 |
INSRR |
0.656 | -0.052 | 3 | 0.604 |
OSR1 |
0.656 | -0.076 | 2 | 0.665 |
DDR2 |
0.656 | 0.032 | 3 | 0.600 |
TEK |
0.656 | -0.045 | 3 | 0.590 |
EPHA1 |
0.655 | 0.005 | 3 | 0.591 |
WEE1_TYR |
0.655 | -0.047 | -1 | 0.578 |
EPHA7 |
0.655 | -0.003 | 2 | 0.603 |
ITK |
0.655 | -0.031 | -1 | 0.674 |
ALPHAK3 |
0.654 | -0.024 | -1 | 0.608 |
FYN |
0.654 | 0.034 | -1 | 0.751 |
TEC |
0.654 | -0.026 | -1 | 0.640 |
BMX |
0.654 | -0.030 | -1 | 0.616 |
PDGFRA |
0.653 | -0.079 | 3 | 0.649 |
ALK |
0.653 | -0.061 | 3 | 0.572 |
PDGFRB |
0.653 | -0.105 | 3 | 0.647 |
EPHB2 |
0.653 | -0.038 | -1 | 0.638 |
MERTK |
0.652 | -0.056 | 3 | 0.608 |
LTK |
0.652 | -0.058 | 3 | 0.594 |
BTK |
0.652 | -0.099 | -1 | 0.640 |
KIT |
0.652 | -0.093 | 3 | 0.623 |
FGFR1 |
0.652 | -0.082 | 3 | 0.617 |
CK1A |
0.651 | -0.077 | -3 | 0.222 |
FLT3 |
0.651 | -0.103 | 3 | 0.619 |
MYO3A |
0.649 | -0.086 | 1 | 0.660 |
MET |
0.648 | -0.069 | 3 | 0.619 |
FLT1 |
0.647 | -0.055 | -1 | 0.671 |
FRK |
0.647 | -0.039 | -1 | 0.720 |
ERBB2 |
0.647 | -0.086 | 1 | 0.675 |
PTK6 |
0.647 | -0.109 | -1 | 0.598 |
EPHA3 |
0.647 | -0.074 | 2 | 0.579 |
LYN |
0.645 | -0.046 | 3 | 0.560 |
FGFR3 |
0.644 | -0.095 | 3 | 0.618 |
EPHA8 |
0.643 | -0.021 | -1 | 0.694 |
PTK2B |
0.642 | -0.058 | -1 | 0.640 |
AAK1 |
0.641 | -0.016 | 1 | 0.440 |
EPHA5 |
0.641 | -0.051 | 2 | 0.593 |
FLT4 |
0.641 | -0.112 | 3 | 0.605 |
NTRK1 |
0.641 | -0.167 | -1 | 0.598 |
SRC |
0.640 | -0.054 | -1 | 0.729 |
SYK |
0.640 | 0.027 | -1 | 0.675 |
STLK3 |
0.639 | -0.144 | 1 | 0.644 |
PTK2 |
0.638 | 0.021 | -1 | 0.718 |
EGFR |
0.637 | -0.069 | 1 | 0.607 |
NTRK2 |
0.637 | -0.172 | 3 | 0.602 |
NTRK3 |
0.635 | -0.149 | -1 | 0.556 |
EPHA2 |
0.634 | -0.035 | -1 | 0.644 |
INSR |
0.634 | -0.142 | 3 | 0.587 |
CK1G3 |
0.633 | -0.087 | -3 | 0.186 |
MATK |
0.632 | -0.130 | -1 | 0.573 |
CSK |
0.632 | -0.137 | 2 | 0.599 |
MUSK |
0.631 | -0.092 | 1 | 0.593 |
ERBB4 |
0.629 | -0.037 | 1 | 0.618 |
YANK2 |
0.628 | -0.077 | 2 | 0.316 |
FGFR4 |
0.628 | -0.125 | -1 | 0.589 |
CK1G2 |
0.626 | -0.053 | -3 | 0.260 |
IGF1R |
0.626 | -0.116 | 3 | 0.536 |
FES |
0.617 | -0.119 | -1 | 0.594 |
ZAP70 |
0.616 | -0.037 | -1 | 0.592 |