Motif 818 (n=157)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0AVT1 | UBA6 | S951 | ochoa | Ubiquitin-like modifier-activating enzyme 6 (Ubiquitin-activating enzyme 6) (EC 6.2.1.45) (Monocyte protein 4) (MOP-4) (Ubiquitin-activating enzyme E1-like protein 2) (E1-L2) | Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:35970836, PubMed:35986001). Specific for ubiquitin, does not activate ubiquitin-like peptides. Also activates UBD/FAT10 conjugation via adenylation of its C-terminal glycine (PubMed:17889673, PubMed:35970836, PubMed:35986001). Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility. {ECO:0000269|PubMed:15202508, ECO:0000269|PubMed:17597759, ECO:0000269|PubMed:17889673, ECO:0000269|PubMed:35970836, ECO:0000269|PubMed:35986001}. |
| A0JLT2 | MED19 | S226 | ochoa | Mediator of RNA polymerase II transcription subunit 19 (Lung cancer metastasis-related protein 1) (Mediator complex subunit 19) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. |
| A6NKT7 | RGPD3 | S1018 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| A8MW92 | PHF20L1 | S356 | ochoa | PHD finger protein 20-like protein 1 | Is a negative regulator of proteasomal degradation of a set of methylated proteins, including DNMT1 and SOX2 (PubMed:24492612, PubMed:29358331). Involved in the maintainance of embryonic stem cells pluripotency, through the regulation of SOX2 levels (By similarity). {ECO:0000250|UniProtKB:Q8CCJ9, ECO:0000269|PubMed:24492612, ECO:0000269|PubMed:29358331}. |
| O00161 | SNAP23 | S95 | psp | Synaptosomal-associated protein 23 (SNAP-23) (Vesicle-membrane fusion protein SNAP-23) | Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion. |
| O00512 | BCL9 | S102 | ochoa | B-cell CLL/lymphoma 9 protein (B-cell lymphoma 9 protein) (Bcl-9) (Protein legless homolog) | Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:11955446}. |
| O00515 | LAD1 | S385 | ochoa | Ladinin-1 (Lad-1) (Linear IgA disease antigen) (LADA) | Anchoring filament protein which is a component of the basement membrane zone. {ECO:0000250}. |
| O00567 | NOP56 | S511 | ochoa | Nucleolar protein 56 (Nucleolar protein 5A) | Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs (PubMed:12777385, PubMed:15574333). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs) (PubMed:12777385, PubMed:39570315). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:15574333, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:39570315}. |
| O00567 | NOP56 | S513 | ochoa | Nucleolar protein 56 (Nucleolar protein 5A) | Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs (PubMed:12777385, PubMed:15574333). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs) (PubMed:12777385, PubMed:39570315). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:15574333, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:39570315}. |
| O14715 | RGPD8 | S1017 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O60524 | NEMF | S831 | ochoa | Ribosome quality control complex subunit NEMF (Antigen NY-CO-1) (Nuclear export mediator factor) (Serologically defined colon cancer antigen 1) | Key component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes as well as their ubiquitin-mediated proteasomal degradation (PubMed:25578875, PubMed:32726578, PubMed:33406423, PubMed:33909987). Thereby, frees 60S subunit ribosomes from the stalled translation complex and prevents the accumulation of nascent polypeptide chains that are potentially toxic for the cell (PubMed:25578875, PubMed:33406423, PubMed:33909987). Within the RQC complex, NEMF specifically binds stalled 60S ribosomal subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety and promotes the recruitment of LTN1 to stalled 60S subunits (PubMed:25578875). Following binding to stalled 60S ribosomal subunits, NEMF mediates CAT tailing by recruiting alanine-charged tRNA to the A-site and directing the elongation of stalled nascent chains independently of mRNA or 40S subunits, leading to non-templated C-terminal alanine extensions (CAT tails) (PubMed:33406423, PubMed:33909987). Mainly recruits alanine-charged tRNAs, but can also other amino acid-charged tRNAs (PubMed:33406423, PubMed:33909987). CAT tailing is required to promote ubiquitination of stalled nascent chains by different E3 ubiquitin-protein ligases (PubMed:33909987). In the canonical RQC pathway (RQC-L), CAT tailing facilitates LTN1-dependent ubiquitination by exposing lysine residues that would otherwise remain buried in the ribosomal exit tunnel (By similarity). In the alternative RQC pathway (RQC-C) CAT tailing creates an C-degron mainly composed of alanine that is recognized by the CRL2(KLHDC10) and RCHY1/PIRH2 E3 ligases, leading to ubiquitination and degradation of stalled nascent chains (PubMed:33909987). NEMF may also indirectly play a role in nuclear export (PubMed:16103875). {ECO:0000250|UniProtKB:Q12532, ECO:0000269|PubMed:16103875, ECO:0000269|PubMed:25578875, ECO:0000269|PubMed:32726578, ECO:0000269|PubMed:33406423, ECO:0000269|PubMed:33909987}. |
| O75410 | TACC1 | S476 | ochoa | Transforming acidic coiled-coil-containing protein 1 (Gastric cancer antigen Ga55) (Taxin-1) | Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863). Might promote the nuclear localization of the receptors (PubMed:20078863). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. {ECO:0000269|PubMed:20078863}. |
| O94955 | RHOBTB3 | S215 | ochoa | Rho-related BTB domain-containing protein 3 (EC 3.6.1.-) | Rab9-regulated ATPase required for endosome to Golgi transport. Involved in transport vesicle docking at the Golgi complex, possibly by participating in release M6PRBP1/TIP47 from vesicles to permit their efficient docking and fusion at the Golgi. Specifically binds Rab9, but not other Rab proteins. Has low intrinsic ATPase activity due to autoinhibition, which is relieved by Rab9. {ECO:0000269|PubMed:19490898}. |
| O94973 | AP2A2 | S622 | ochoa | AP-2 complex subunit alpha-2 (100 kDa coated vesicle protein C) (Adaptor protein complex AP-2 subunit alpha-2) (Adaptor-related protein complex 2 subunit alpha-2) (Alpha-adaptin C) (Alpha2-adaptin) (Clathrin assembly protein complex 2 alpha-C large chain) (Huntingtin yeast partner J) (Huntingtin-interacting protein 9) (HIP-9) (Huntingtin-interacting protein J) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit) | Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (PubMed:23676497). The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity). {ECO:0000250, ECO:0000269|PubMed:12960147, ECO:0000269|PubMed:14745134, ECO:0000269|PubMed:15473838, ECO:0000269|PubMed:19033387, ECO:0000269|PubMed:23676497}. |
| O95149 | SNUPN | S329 | ochoa | Snurportin-1 (RNA U transporter 1) | Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs. {ECO:0000269|PubMed:10209022, ECO:0000269|PubMed:15920472, ECO:0000269|PubMed:16030253, ECO:0000269|PubMed:38413582, ECO:0000269|PubMed:9670026}. |
| O95490 | ADGRL2 | S1350 | ochoa | Adhesion G protein-coupled receptor L2 (Calcium-independent alpha-latrotoxin receptor 2) (CIRL-2) (Latrophilin homolog 1) (Latrophilin-2) (Lectomedin-1) | Orphan adhesion G-protein coupled receptor (aGPCR), which mediates synapse specificity (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (By similarity). Following G-protein coupled receptor activation, associates with cell adhesion molecules that are expressed at the surface of adjacent cells to direct synapse specificity. Specifically mediates the establishment of perforant-path synapses on CA1-region pyramidal neurons in the hippocampus. Localizes to postsynaptic spines in excitatory synapses in the S.lacunosum-moleculare and interacts with presynaptic cell adhesion molecules, such as teneurins, promoting synapse formation (By similarity). {ECO:0000250|UniProtKB:Q80TS3, ECO:0000250|UniProtKB:Q8JZZ7}. |
| P00533 | EGFR | S720 | ochoa | Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1) | Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:10805725, PubMed:27153536, PubMed:2790960, PubMed:35538033). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:12297049, PubMed:15611079, PubMed:17909029, PubMed:20837704, PubMed:27153536, PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity). Plays a role in mammalian pain signaling (long-lasting hypersensitivity) (By similarity). {ECO:0000250|UniProtKB:Q01279, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11116146, ECO:0000269|PubMed:11483589, ECO:0000269|PubMed:11602604, ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12873986, ECO:0000269|PubMed:15374980, ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:15611079, ECO:0000269|PubMed:17115032, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:19560417, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:27153536, ECO:0000269|PubMed:2790960, ECO:0000269|PubMed:35538033, ECO:0000269|PubMed:7679104, ECO:0000269|PubMed:8144591, ECO:0000269|PubMed:9419975}.; FUNCTION: Isoform 2 may act as an antagonist of EGF action.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}. |
| P04626 | ERBB2 | S728 | ochoa | Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340) | Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. {ECO:0000305}.; FUNCTION: In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. {ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:15380516, ECO:0000269|PubMed:21555369}. |
| P05387 | RPLP2 | S29 | ochoa | Large ribosomal subunit protein P2 (60S acidic ribosomal protein P2) (Renal carcinoma antigen NY-REN-44) | Plays an important role in the elongation step of protein synthesis. |
| P0DJD0 | RGPD1 | S1002 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | S1010 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P0DMV8 | HSPA1A | S106 | ochoa | Heat shock 70 kDa protein 1A (Heat shock 70 kDa protein 1) (HSP70-1) (HSP70.1) (Heat shock protein family A member 1A) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:24318877, PubMed:26865365). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). Required as a co-chaperone for optimal STUB1/CHIP ubiquitination of NFATC3 (By similarity). Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Involved in the clearance of misfolded PRDM1/Blimp-1 proteins. Sequesters them in the cytoplasm and promotes their association with SYNV1/HRD1, leading to proteasomal degradation (PubMed:28842558). {ECO:0000250|UniProtKB:P0DMW0, ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:27137183, ECO:0000269|PubMed:27708256, ECO:0000269|PubMed:28842558, ECO:0000269|PubMed:9499401, ECO:0000303|PubMed:24012426, ECO:0000303|PubMed:26865365}.; FUNCTION: (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. {ECO:0000269|PubMed:16537599}. |
| P0DMV9 | HSPA1B | S106 | ochoa | Heat shock 70 kDa protein 1B (Heat shock 70 kDa protein 2) (HSP70-2) (HSP70.2) (Heat shock protein family A member 1B) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:24318877, PubMed:26865365). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). {ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:27137183, ECO:0000269|PubMed:27708256, ECO:0000303|PubMed:24012426, ECO:0000303|PubMed:26865365}.; FUNCTION: (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. {ECO:0000269|PubMed:16537599}. |
| P10398 | ARAF | Y296 | ochoa | Serine/threonine-protein kinase A-Raf (EC 2.7.11.1) (Proto-oncogene A-Raf) (Proto-oncogene A-Raf-1) (Proto-oncogene Pks) | Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade. Phosphorylates PFKFB2 (PubMed:36402789). {ECO:0000269|PubMed:22609986, ECO:0000269|PubMed:36402789}.; FUNCTION: [Isoform 2]: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation. {ECO:0000269|PubMed:22609986}. |
| P12883 | MYH7 | S1463 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P13533 | MYH6 | S1465 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P20810 | CAST | S133 | ochoa|psp | Calpastatin (Calpain inhibitor) (Sperm BS-17 component) | Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. |
| P21333 | FLNA | S912 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P21860 | ERBB3 | S717 | ochoa | Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3) | Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134). Involved in the regulation of myeloid cell differentiation (PubMed:27416908). {ECO:0000269|PubMed:15358134, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:27416908}. |
| P28290 | ITPRID2 | S354 | ochoa | Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) | None |
| P35637 | FUS | S340 | ochoa | RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein) | DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response (PubMed:27731383). Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing (PubMed:26124092). Also binds its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay (PubMed:24204307). Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (PubMed:10567410). In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity). {ECO:0000250|UniProtKB:P56959, ECO:0000269|PubMed:10567410, ECO:0000269|PubMed:21256132, ECO:0000269|PubMed:24204307, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27731383}. |
| P38432 | COIL | S202 | psp | Coilin (p80-coilin) | Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs. {ECO:0000269|PubMed:7679389}. |
| P41236 | PPP1R2 | S20 | ochoa | Protein phosphatase inhibitor 2 (IPP-2) | Inhibitor of protein-phosphatase 1. |
| P46100 | ATRX | S784 | ochoa|psp | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P46100 | ATRX | S1061 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P49006 | MARCKSL1 | S93 | ochoa | MARCKS-related protein (MARCKS-like protein 1) (Macrophage myristoylated alanine-rich C kinase substrate) (Mac-MARCKS) (MacMARCKS) | Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation (PubMed:22751924). When unphosphorylated, induces cell migration (By similarity). When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration (By similarity). May be involved in coupling the protein kinase C and calmodulin signal transduction systems (By similarity). {ECO:0000250|UniProtKB:P28667, ECO:0000269|PubMed:22751924}. |
| P49792 | RANBP2 | S1993 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P49792 | RANBP2 | S2626 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P54277 | PMS1 | S673 | ochoa | PMS1 protein homolog 1 (DNA mismatch repair protein PMS1) | Probably involved in the repair of mismatches in DNA. {ECO:0000269|PubMed:10748105}. |
| P60484 | PTEN | S229 | psp | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.16) (EC 3.1.3.48) (EC 3.1.3.67) (Inositol polyphosphate 3-phosphatase) (EC 3.1.3.-) (Mutated in multiple advanced cancers 1) (Phosphatase and tensin homolog) | Dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins (PubMed:9187108, PubMed:9256433, PubMed:9616126). Also functions as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring of PtdIns(3,4,5)P3/phosphatidylinositol 3,4,5-trisphosphate, PtdIns(3,4)P2/phosphatidylinositol 3,4-diphosphate and PtdIns3P/phosphatidylinositol 3-phosphate with a preference for PtdIns(3,4,5)P3 (PubMed:16824732, PubMed:26504226, PubMed:9593664, PubMed:9811831). Furthermore, this enzyme can also act as a cytosolic inositol 3-phosphatase acting on Ins(1,3,4,5,6)P5/inositol 1,3,4,5,6 pentakisphosphate and possibly Ins(1,3,4,5)P4/1D-myo-inositol 1,3,4,5-tetrakisphosphate (PubMed:11418101, PubMed:15979280). Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (PubMed:31492966, PubMed:37279284). The unphosphorylated form cooperates with MAGI2 to suppress AKT1 activation (PubMed:11707428). In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement (PubMed:22279049). Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation (PubMed:22279049). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces PTEN phosphorylation which changes its binding preference from the p85 regulatory subunit of the PI3K kinase complex to DLC1 and results in translocation of the PTEN-DLC1 complex to the posterior of migrating cells to promote RHOA activation (PubMed:26166433). Meanwhile, TNS3 switches binding preference from DLC1 to p85 and the TNS3-p85 complex translocates to the leading edge of migrating cells to activate RAC1 activation (PubMed:26166433). Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Involved in the regulation of synaptic function in excitatory hippocampal synapses. Recruited to the postsynaptic membrane upon NMDA receptor activation, is required for the modulation of synaptic activity during plasticity. Enhancement of lipid phosphatase activity is able to drive depression of AMPA receptor-mediated synaptic responses, activity required for NMDA receptor-dependent long-term depression (LTD) (By similarity). May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability (PubMed:10468583, PubMed:18716620). {ECO:0000250|UniProtKB:O08586, ECO:0000250|UniProtKB:O54857, ECO:0000269|PubMed:10468583, ECO:0000269|PubMed:11418101, ECO:0000269|PubMed:11707428, ECO:0000269|PubMed:15979280, ECO:0000269|PubMed:16824732, ECO:0000269|PubMed:18716620, ECO:0000269|PubMed:22279049, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26504226, ECO:0000269|PubMed:31492966, ECO:0000269|PubMed:37279284, ECO:0000269|PubMed:9187108, ECO:0000269|PubMed:9256433, ECO:0000269|PubMed:9593664, ECO:0000269|PubMed:9616126, ECO:0000269|PubMed:9811831}.; FUNCTION: [Isoform alpha]: Functional kinase, like isoform 1 it antagonizes the PI3K-AKT/PKB signaling pathway. Plays a role in mitochondrial energetic metabolism by promoting COX activity and ATP production, via collaboration with isoform 1 in increasing protein levels of PINK1. {ECO:0000269|PubMed:23744781}. |
| P62081 | RPS7 | S119 | ochoa | Small ribosomal subunit protein eS7 (40S ribosomal protein S7) | Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Required for rRNA maturation (PubMed:19061985). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:19061985, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| P68104 | EEF1A1 | S396 | ochoa|psp | Elongation factor 1-alpha 1 (EF-1-alpha-1) (EC 3.6.5.-) (Elongation factor Tu) (EF-Tu) (Eukaryotic elongation factor 1 A-1) (eEF1A-1) (Leukocyte receptor cluster member 7) | Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623, PubMed:36638793). Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623, PubMed:36638793). The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623). Also plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1 (PubMed:17177976). Also plays a role in cytoskeleton organization by promoting actin bundling (By similarity). {ECO:0000250|UniProtKB:P68105, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:26593721, ECO:0000269|PubMed:26651998, ECO:0000269|PubMed:36123449, ECO:0000269|PubMed:36264623, ECO:0000269|PubMed:36638793}.; FUNCTION: (Microbial infection) Required for the translation of viral proteins and viral replication during human coronavirus SARS-CoV-2 infection. {ECO:0000269|PubMed:33495306}. |
| P78368 | CSNK1G2 | S366 | ochoa | Casein kinase I isoform gamma-2 (CKI-gamma 2) (EC 2.7.11.1) | Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation (PubMed:15077195, PubMed:15917222, PubMed:18794808, PubMed:19005213). Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate (By similarity). Involved in regulation of reactive oxygen species (ROS) levels (PubMed:37099597). {ECO:0000250|UniProtKB:P48729, ECO:0000250|UniProtKB:Q8BVP5, ECO:0000269|PubMed:15077195, ECO:0000269|PubMed:15917222, ECO:0000269|PubMed:18794808, ECO:0000269|PubMed:19005213, ECO:0000269|PubMed:37099597}. |
| Q00013 | MPP1 | S260 | ochoa | 55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) | Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity (By similarity). {ECO:0000250}. |
| Q00987 | MDM2 | S350 | ochoa | E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2) | E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome (PubMed:29681526). Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also a component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (PubMed:12821780, PubMed:15053880, PubMed:15195100, PubMed:15632057, PubMed:16337594, PubMed:17290220, PubMed:19098711, PubMed:19219073, PubMed:19837670, PubMed:19965871, PubMed:20173098, PubMed:20385133, PubMed:20858735, PubMed:22128911). Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (By similarity). Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity). Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis (PubMed:30879903). Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis (PubMed:30879903). {ECO:0000250|UniProtKB:P23804, ECO:0000269|PubMed:12821780, ECO:0000269|PubMed:15053880, ECO:0000269|PubMed:15195100, ECO:0000269|PubMed:15632057, ECO:0000269|PubMed:16337594, ECO:0000269|PubMed:17290220, ECO:0000269|PubMed:19098711, ECO:0000269|PubMed:19219073, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:20173098, ECO:0000269|PubMed:20385133, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:22128911, ECO:0000269|PubMed:29681526, ECO:0000269|PubMed:30879903}. |
| Q01804 | OTUD4 | S349 | ochoa | OTU domain-containing protein 4 (EC 3.4.19.12) (HIV-1-induced protein HIN-1) | Deubiquitinase which hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein (PubMed:23827681, PubMed:25944111, PubMed:29395066). May negatively regulate inflammatory and pathogen recognition signaling in innate immune response. Upon phosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptor and Toll-like receptor signaling pathway, specifically deubiquitinates 'Lys-63'-polyubiquitinated MYD88 adapter protein triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators (PubMed:29395066). Independently of the catalytic activity, acts as a scaffold for alternative deubiquitinases to assemble specific deubiquitinase-substrate complexes. Associates with USP7 and USP9X deubiquitinases to stabilize alkylation repair enzyme ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111). {ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:25944111, ECO:0000269|PubMed:29395066}. |
| Q01804 | OTUD4 | S351 | ochoa | OTU domain-containing protein 4 (EC 3.4.19.12) (HIV-1-induced protein HIN-1) | Deubiquitinase which hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein (PubMed:23827681, PubMed:25944111, PubMed:29395066). May negatively regulate inflammatory and pathogen recognition signaling in innate immune response. Upon phosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptor and Toll-like receptor signaling pathway, specifically deubiquitinates 'Lys-63'-polyubiquitinated MYD88 adapter protein triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators (PubMed:29395066). Independently of the catalytic activity, acts as a scaffold for alternative deubiquitinases to assemble specific deubiquitinase-substrate complexes. Associates with USP7 and USP9X deubiquitinases to stabilize alkylation repair enzyme ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111). {ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:25944111, ECO:0000269|PubMed:29395066}. |
| Q03188 | CENPC | S277 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
| Q07869 | PPARA | S230 | psp | Peroxisome proliferator-activated receptor alpha (PPAR-alpha) (Nuclear receptor subfamily 1 group C member 1) | Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as a transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2. {ECO:0000269|PubMed:10195690, ECO:0000269|PubMed:24043310, ECO:0000269|PubMed:7629123, ECO:0000269|PubMed:7684926, ECO:0000269|PubMed:9556573}. |
| Q08174 | PCDH1 | S918 | ochoa | Protocadherin-1 (Cadherin-like protein 1) (Protocadherin-42) (PC42) | May be involved in cell-cell interaction processes and in cell adhesion. |
| Q08499 | PDE4D | S362 | ochoa | 3',5'-cyclic-AMP phosphodiesterase 4D (EC 3.1.4.53) (DPDE3) (PDE43) (cAMP-specific phosphodiesterase 4D) | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:9371713}. |
| Q0JRZ9 | FCHO2 | S304 | ochoa | F-BAR domain only protein 2 | Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor. {ECO:0000269|PubMed:17540576, ECO:0000269|PubMed:20448150, ECO:0000269|PubMed:21762413, ECO:0000269|PubMed:22323290}. |
| Q12873 | CHD3 | S73 | ochoa | Chromodomain-helicase-DNA-binding protein 3 (CHD-3) (EC 3.6.4.-) (ATP-dependent helicase CHD3) (Mi-2 autoantigen 240 kDa protein) (Mi2-alpha) (Zinc finger helicase) (hZFH) | ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA (PubMed:28977666). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666, PubMed:30397230, PubMed:9804427). Involved in transcriptional repression as part of the NuRD complex (PubMed:27068747). Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity (PubMed:17626165). {ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:27068747, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:30397230, ECO:0000269|PubMed:9804427}. |
| Q12873 | CHD3 | S308 | ochoa | Chromodomain-helicase-DNA-binding protein 3 (CHD-3) (EC 3.6.4.-) (ATP-dependent helicase CHD3) (Mi-2 autoantigen 240 kDa protein) (Mi2-alpha) (Zinc finger helicase) (hZFH) | ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA (PubMed:28977666). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666, PubMed:30397230, PubMed:9804427). Involved in transcriptional repression as part of the NuRD complex (PubMed:27068747). Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity (PubMed:17626165). {ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:27068747, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:30397230, ECO:0000269|PubMed:9804427}. |
| Q12955 | ANK3 | S4290 | ochoa | Ankyrin-3 (ANK-3) (Ankyrin-G) | Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (PubMed:7836469). In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). {ECO:0000250|UniProtKB:G5E8K5, ECO:0000250|UniProtKB:O70511, ECO:0000269|PubMed:23903368, ECO:0000269|PubMed:7836469}.; FUNCTION: [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. {ECO:0000305|PubMed:17974005}. |
| Q13610 | PWP1 | S249 | ochoa | Periodic tryptophan protein 1 homolog (Keratinocyte protein IEF SSP 9502) | Chromatin-associated factor that regulates transcription (PubMed:29065309). Regulates Pol I-mediated rRNA biogenesis and, probably, Pol III-mediated transcription (PubMed:29065309). Regulates the epigenetic status of rDNA (PubMed:29065309). {ECO:0000269|PubMed:29065309}. |
| Q14DG7 | TMEM132B | S792 | ochoa | Transmembrane protein 132B | None |
| Q15361 | TTF1 | S226 | ochoa | Transcription termination factor 1 (TTF-1) (RNA polymerase I termination factor) (Transcription termination factor I) (TTF-I) | Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity. {ECO:0000250|UniProtKB:Q62187, ECO:0000269|PubMed:7597036}. |
| Q15424 | SAFB | S507 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q15545 | TAF7 | S159 | ochoa | Transcription initiation factor TFIID subunit 7 (RNA polymerase II TBP-associated factor subunit F) (Transcription initiation factor TFIID 55 kDa subunit) (TAF(II)55) (TAFII-55) (TAFII55) | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:10438527, PubMed:33795473). TAF7 forms a promoter DNA binding subcomplex of TFIID, together with TAF1 and TAF2 (PubMed:33795473). Part of a TFIID complex containing TAF10 (TFIID alpha) and a TFIID complex lacking TAF10 (TFIID beta) (PubMed:10438527). {ECO:0000269|PubMed:10438527, ECO:0000269|PubMed:33795473}. |
| Q15648 | MED1 | S1368 | ochoa | Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}. |
| Q15652 | JMJD1C | S630 | ochoa | Probable JmjC domain-containing histone demethylation protein 2C (EC 1.14.11.-) (Jumonji domain-containing protein 1C) (Thyroid receptor-interacting protein 8) (TR-interacting protein 8) (TRIP-8) | Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity). {ECO:0000250}. |
| Q1ED39 | KNOP1 | S297 | ochoa | Lysine-rich nucleolar protein 1 (Protein FAM191A) (Testis-specific gene 118 protein) | None |
| Q29RF7 | PDS5A | S1223 | ochoa | Sister chromatid cohesion protein PDS5 homolog A (Cell proliferation-inducing gene 54 protein) (Sister chromatid cohesion protein 112) (SCC-112) | Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15855230, ECO:0000269|PubMed:19907496}. |
| Q2M1Z3 | ARHGAP31 | S1105 | ochoa | Rho GTPase-activating protein 31 (Cdc42 GTPase-activating protein) | Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading, polarized lamellipodia formation and cell migration. {ECO:0000269|PubMed:12192056, ECO:0000269|PubMed:16519628}. |
| Q32MZ4 | LRRFIP1 | S581 | ochoa | Leucine-rich repeat flightless-interacting protein 1 (LRR FLII-interacting protein 1) (GC-binding factor 2) (TAR RNA-interacting protein) | Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:10364563, ECO:0000269|PubMed:14522076, ECO:0000269|PubMed:16199883, ECO:0000269|PubMed:19265123, ECO:0000269|PubMed:9705290}. |
| Q3L8U1 | CHD9 | S612 | ochoa | Chromodomain-helicase-DNA-binding protein 9 (CHD-9) (EC 3.6.4.-) (ATP-dependent helicase CHD9) (Chromatin-related mesenchymal modulator) (CReMM) (Chromatin-remodeling factor CHROM1) (Kismet homolog 2) (PPAR-alpha-interacting complex protein 320 kDa) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) | Probable ATP-dependent chromatin-remodeling factor. Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Has DNA-dependent ATPase activity and binds to A/T-rich DNA. Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis (By similarity). {ECO:0000250, ECO:0000269|PubMed:16095617, ECO:0000269|PubMed:16554032}. |
| Q53EL6 | PDCD4 | S317 | ochoa | Programmed cell death protein 4 (Neoplastic transformation inhibitor protein) (Nuclear antigen H731-like) (Protein 197/15a) | Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity). {ECO:0000250, ECO:0000269|PubMed:16357133, ECO:0000269|PubMed:16449643, ECO:0000269|PubMed:17053147, ECO:0000269|PubMed:18296639, ECO:0000269|PubMed:19153607, ECO:0000269|PubMed:19204291}. |
| Q5S007 | LRRK2 | S955 | psp | Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin) | Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking (PubMed:17114044, PubMed:20949042, PubMed:21850687, PubMed:22012985, PubMed:23395371, PubMed:24687852, PubMed:25201882, PubMed:26014385, PubMed:26824392, PubMed:27830463, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB29, RAB35, and RAB43 (PubMed:23395371, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421, PubMed:38127736). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PubMed:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (PubMed:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:17114044). Plays a role in synaptic vesicle trafficking (PubMed:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PubMed:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PubMed:22012985). Phosphorylates PRDX3 (PubMed:21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Acts as a positive regulator of innate immunity by mediating phosphorylation of RIPK2 downstream of NOD1 and NOD2, thereby enhancing RIPK2 activation (PubMed:27830463). Independent of its kinase activity, inhibits the proteasomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PubMed:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PubMed:18230735, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29212815). Recruited by RAB29/RAB7L1 to overloaded lysosomes where it phosphorylates and stabilizes RAB8A and RAB10 which promote lysosomal content release and suppress lysosomal enlargement through the EHBP1 and EHBP1L1 effector proteins (PubMed:30209220, PubMed:38227290). {ECO:0000269|PubMed:17114044, ECO:0000269|PubMed:18230735, ECO:0000269|PubMed:20949042, ECO:0000269|PubMed:21850687, ECO:0000269|PubMed:22012985, ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:24687852, ECO:0000269|PubMed:25201882, ECO:0000269|PubMed:26014385, ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:27830463, ECO:0000269|PubMed:28720718, ECO:0000269|PubMed:29125462, ECO:0000269|PubMed:29127255, ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:30209220, ECO:0000269|PubMed:30398148, ECO:0000269|PubMed:30635421, ECO:0000269|PubMed:38127736, ECO:0000269|PubMed:38227290}. |
| Q5SW79 | CEP170 | S1219 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5T3I0 | GPATCH4 | S117 | ochoa | G patch domain-containing protein 4 | None |
| Q5T5Y3 | CAMSAP1 | S1372 | ochoa | Calmodulin-regulated spectrin-associated protein 1 | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19508979, PubMed:21834987, PubMed:24117850, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and stabilizes microtubules (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation (PubMed:24486153, PubMed:24706919). Through interaction with spectrin may regulate neurite outgrowth (PubMed:24117850). {ECO:0000269|PubMed:19508979, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:24117850, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919}. |
| Q5UIP0 | RIF1 | S1579 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5VST9 | OBSCN | S5387 | ochoa | Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) | Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). {ECO:0000250|UniProtKB:A2AAJ9, ECO:0000269|PubMed:11448995, ECO:0000269|PubMed:16205939, ECO:0000269|PubMed:28826662}. |
| Q5VTE0 | EEF1A1P5 | S396 | ochoa | Putative elongation factor 1-alpha-like 3 (EF-1-alpha-like 3) (Eukaryotic elongation factor 1 A-like 3) (eEF1A-like 3) (Eukaryotic translation elongation factor 1 alpha-1 pseudogene 5) | This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. {ECO:0000250}. |
| Q5VTT5 | MYOM3 | S1263 | ochoa | Myomesin-3 (Myomesin family member 3) | May link the intermediate filament cytoskeleton to the M-disk of the myofibrils in striated muscle. {ECO:0000250}. |
| Q5VWQ8 | DAB2IP | S289 | ochoa | Disabled homolog 2-interacting protein (DAB2 interaction protein) (DAB2-interacting protein) (ASK-interacting protein 1) (AIP-1) (DOC-2/DAB-2 interactive protein) | Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Involved in several processes such as innate immune response, inflammation and cell growth inhibition, apoptosis, cell survival, angiogenesis, cell migration and maturation. Also plays a role in cell cycle checkpoint control; reduces G1 phase cyclin levels resulting in G0/G1 cell cycle arrest. Mediates signal transduction by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF), interferon (IFN) or lipopolysaccharide (LPS). Modulates the balance between phosphatidylinositol 3-kinase (PI3K)-AKT-mediated cell survival and apoptosis stimulated kinase (MAP3K5)-JNK signaling pathways; sequesters both AKT1 and MAP3K5 and counterbalances the activity of each kinase by modulating their phosphorylation status in response to pro-inflammatory stimuli. Acts as a regulator of the endoplasmic reticulum (ER) unfolded protein response (UPR) pathway; specifically involved in transduction of the ER stress-response to the JNK cascade through ERN1. Mediates TNF-alpha-induced apoptosis activation by facilitating dissociation of inhibitor 14-3-3 from MAP3K5; recruits the PP2A phosphatase complex which dephosphorylates MAP3K5 on 'Ser-966', leading to the dissociation of 13-3-3 proteins and activation of the MAP3K5-JNK signaling pathway in endothelial cells. Also mediates TNF/TRAF2-induced MAP3K5-JNK activation, while it inhibits CHUK-NF-kappa-B signaling. Acts a negative regulator in the IFN-gamma-mediated JAK-STAT signaling cascade by inhibiting smooth muscle cell (VSMCs) proliferation and intimal expansion, and thus, prevents graft arteriosclerosis (GA). Acts as a GTPase-activating protein (GAP) for the ADP ribosylation factor 6 (ARF6), Ras and RAB40C (PubMed:29156729). Promotes hydrolysis of the ARF6-bound GTP and thus, negatively regulates phosphatidylinositol 4,5-bisphosphate (PIP2)-dependent TLR4-TIRAP-MyD88 and NF-kappa-B signaling pathways in endothelial cells in response to lipopolysaccharides (LPS). Binds specifically to phosphatidylinositol 4-phosphate (PtdIns4P) and phosphatidylinositol 3-phosphate (PtdIns3P). In response to vascular endothelial growth factor (VEGFA), acts as a negative regulator of the VEGFR2-PI3K-mediated angiogenic signaling pathway by inhibiting endothelial cell migration and tube formation. In the developing brain, promotes both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex in a glial-dependent locomotion process. Probable downstream effector of the Reelin signaling pathway; promotes Purkinje cell (PC) dendrites development and formation of cerebellar synapses. Also functions as a tumor suppressor protein in prostate cancer progression; prevents cell proliferation and epithelial-to-mesenchymal transition (EMT) through activation of the glycogen synthase kinase-3 beta (GSK3B)-induced beta-catenin and inhibition of PI3K-AKT and Ras-MAPK survival downstream signaling cascades, respectively. {ECO:0000269|PubMed:12813029, ECO:0000269|PubMed:17389591, ECO:0000269|PubMed:18292600, ECO:0000269|PubMed:19033661, ECO:0000269|PubMed:19903888, ECO:0000269|PubMed:19948740, ECO:0000269|PubMed:20080667, ECO:0000269|PubMed:20154697, ECO:0000269|PubMed:21700930, ECO:0000269|PubMed:22696229, ECO:0000269|PubMed:29156729}. |
| Q6DCA0 | AMMECR1L | S29 | ochoa | AMMECR1-like protein | None |
| Q6NXS1 | PPP1R2B | S20 | ochoa | Protein phosphatase inhibitor 2 family member B (PPP1R2 family member B) (Protein phosphatase 1, regulatory subunit 2 pseudogene 3) (Protein phosphatase inhibitor 2-like protein 3) | Inhibitor of protein-phosphatase 1. {ECO:0000269|PubMed:23506001}. |
| Q6PD62 | CTR9 | S1015 | ochoa | RNA polymerase-associated protein CTR9 homolog (SH2 domain-binding protein 1) | Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3) and dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of the SET1 complex. Involved in transcriptional regulation of IL6-responsive genes and in JAK-STAT pathway; may regulate DNA-association of STAT3 (By similarity). {ECO:0000250|UniProtKB:Q62018, ECO:0000269|PubMed:16024656, ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:19345177, ECO:0000269|PubMed:19952111, ECO:0000269|PubMed:20178742, ECO:0000269|PubMed:20541477, ECO:0000269|PubMed:21329879}. |
| Q6PKG0 | LARP1 | S215 | ochoa | La-related protein 1 (La ribonucleoprotein domain family member 1) | RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:25940091, ECO:0000269|PubMed:26206669, ECO:0000269|PubMed:28379136, ECO:0000269|PubMed:28650797, ECO:0000269|PubMed:28673543, ECO:0000269|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| Q6SJ93 | FAM111B | S288 | ochoa | Serine protease FAM111B (EC 3.4.21.-) (Cancer-associated nucleoprotein) | Serine protease. {ECO:0000250|UniProtKB:Q96PZ2}. |
| Q6WKZ4 | RAB11FIP1 | S184 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
| Q6WKZ4 | RAB11FIP1 | S186 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
| Q71F23 | CENPU | S229 | ochoa | Centromere protein U (CENP-U) (Centromere protein of 50 kDa) (CENP-50) (Interphase centromere complex protein 24) (KSHV latent nuclear antigen-interacting protein 1) (MLF1-interacting protein) (Polo-box-interacting protein 1) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression. {ECO:0000269|PubMed:12941884, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:17081991}. |
| Q7Z2W7 | TRPM8 | S1040 | psp | Transient receptor potential cation channel subfamily M member 8 (Long transient receptor potential channel 6) (LTrpC-6) (LTrpC6) (Transient receptor potential p8) (Trp-p8) | Non-selective ion channel permeable to monovalent and divalent cations, including Na(+), K(+), and Ca(2+), with higher permeability for Ca(2+). Activated by multiple factors, such as temperature, voltage, pressure, and changes in osmolality. Activated by cool temperatures (<23-28 degrees Celsius) and by chemical ligands evoking a sensation of coolness, such as menthol and icilin therefore plays a central role in the detection of environmental cold temperatures (PubMed:15306801, PubMed:15852009, PubMed:16174775, PubMed:25559186, PubMed:37857704). TRPM8 is a voltage-dependent channel; its activation by cold or chemical ligands shifts its voltage thresholds towards physiological membrane potentials, leading to the opening of the channel (PubMed:15306801). In addition to its critical role in temperature sensing, regulates basal tear secretion by sensing evaporation-induced cooling and changes in osmolality (By similarity). May plays a role in prostate cancer cell migration (PubMed:16174775, PubMed:25559186). {ECO:0000250|UniProtKB:Q8R4D5, ECO:0000269|PubMed:15306801, ECO:0000269|PubMed:15852009, ECO:0000269|PubMed:16174775, ECO:0000269|PubMed:25559186, ECO:0000269|PubMed:37857704}.; FUNCTION: [Isoform 2]: Negatively regulates menthol- and cold-induced channel activity by stabilizing the closed state of the channel. {ECO:0000269|PubMed:22128173}.; FUNCTION: [Isoform 3]: Negatively regulates menthol- and cold-induced channel activity by stabilizing the closed state of the channel. {ECO:0000269|PubMed:22128173}. |
| Q7Z3J3 | RGPD4 | S1018 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z4V5 | HDGFL2 | S230 | ochoa | Hepatoma-derived growth factor-related protein 2 (HDGF-related protein 2) (HRP-2) (Hepatoma-derived growth factor 2) (HDGF-2) | Acts as an epigenetic regulator of myogenesis in cooperation with DPF3a (isoform 2 of DPF3/BAF45C) (PubMed:32459350). Associates with the BAF complex via its interaction with DPF3a and HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters (PubMed:32459350). Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs (PubMed:26721387). Preferentially binds to chromatin regions marked by H3K9me3, H3K27me3 and H3K36me2 (PubMed:26721387, PubMed:32459350). Involved in cellular growth control, through the regulation of cyclin D1 expression (PubMed:25689719). {ECO:0000269|PubMed:25689719, ECO:0000269|PubMed:26721387, ECO:0000269|PubMed:32459350}. |
| Q86W34 | AMZ2 | S226 | ochoa | Archaemetzincin-2 (EC 3.4.-.-) (Archeobacterial metalloproteinase-like protein 2) | Probable zinc metalloprotease. {ECO:0000250|UniProtKB:Q8TXW1}. |
| Q8IZT6 | ASPM | S3426 | ochoa | Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog) | Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis. {ECO:0000269|PubMed:12355089, ECO:0000269|PubMed:15972725, ECO:0000269|PubMed:28436967}. |
| Q8N0Z3 | SPICE1 | S314 | ochoa | Spindle and centriole-associated protein 1 (Coiled-coil domain-containing protein 52) (Spindle and centriole-associated protein) | Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome congression in mitosis. {ECO:0000269|PubMed:20736305}. |
| Q8NI27 | THOC2 | S1388 | ochoa | THO complex subunit 2 (Tho2) (hTREX120) | Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). Required for efficient export of polyadenylated RNA and spliced mRNA (PubMed:23222130). The THOC1-THOC2-THOC3 core complex alone is sufficient to bind export factor NXF1-NXT1 and promote ATPase activity of DDX39B; in the complex THOC2 is the only component that directly interacts with DDX39B (PubMed:33191911). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15833825, PubMed:15998806, PubMed:17190602). Required for NXF1 localization to the nuclear rim (PubMed:22893130). THOC2 (and probably the THO complex) is involved in releasing mRNA from nuclear speckle domains. {ECO:0000269|PubMed:11979277, ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:22893130, ECO:0000269|PubMed:23222130, ECO:0000269|PubMed:33191911}.; FUNCTION: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269|PubMed:18974867}. |
| Q8TDM6 | DLG5 | S972 | ochoa | Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG) | Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). {ECO:0000250|UniProtKB:E9Q9R9, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:28169360}. |
| Q8WXI2 | CNKSR2 | S503 | ochoa | Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR 2) (CNK homolog protein 2) (CNK2) | May function as an adapter protein or regulator of Ras signaling pathways. {ECO:0000269|PubMed:14597674}. |
| Q92541 | RTF1 | S650 | ochoa | RNA polymerase-associated protein RTF1 homolog | Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Binds single-stranded DNA. Required for maximal induction of heat-shock genes. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of a SET1 complex (By similarity). {ECO:0000250, ECO:0000269|PubMed:19345177, ECO:0000269|PubMed:20178742}. |
| Q92804 | TAF15 | S289 | ochoa | TATA-binding protein-associated factor 2N (68 kDa TATA-binding protein-associated factor) (TAF(II)68) (TAFII68) (RNA-binding protein 56) | RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Can enter the preinitiation complex together with the RNA polymerase II (Pol II). {ECO:0000269|PubMed:19124016, ECO:0000269|PubMed:21256132}. |
| Q96A65 | EXOC4 | S219 | ochoa | Exocyst complex component 4 (Exocyst complex component Sec8) | Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. {ECO:0000250|UniProtKB:Q62824}. |
| Q96AC1 | FERMT2 | S414 | ochoa | Fermitin family homolog 2 (Kindlin-2) (Mitogen-inducible gene 2 protein) (MIG-2) (Pleckstrin homology domain-containing family C member 1) (PH domain-containing family C member 1) | Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling. {ECO:0000269|PubMed:12679033, ECO:0000269|PubMed:18458155, ECO:0000269|PubMed:21325030, ECO:0000269|PubMed:22030399, ECO:0000269|PubMed:22078565, ECO:0000269|PubMed:22699938}. |
| Q96C57 | CUSTOS | S202 | ochoa | Protein CUSTOS | Plays a role in the regulation of Wnt signaling pathway during early development. {ECO:0000250|UniProtKB:A9C3N6}. |
| Q96DZ5 | CLIP3 | S402 | ochoa | CAP-Gly domain-containing linker protein 3 (Cytoplasmic linker protein 170-related 59 kDa protein) (CLIP-170-related 59 kDa protein) (CLIPR-59) | Functions as a cytoplasmic linker protein. Involved in TGN-endosome dynamics. May modulate the cellular compartmentalization of AKT kinase family and promote its cell membrane localization, thereby playing a role in glucose transport in adipocytes. {ECO:0000269|PubMed:19139280}. |
| Q96F86 | EDC3 | S110 | ochoa | Enhancer of mRNA-decapping protein 3 (LSM16 homolog) (YjeF N-terminal domain-containing protein 2) (YjeF_N2) (hYjeF_N2) (YjeF domain-containing protein 1) | Binds single-stranded RNA. Involved in the process of mRNA degradation and in the positive regulation of mRNA decapping. May play a role in spermiogenesis and oogenesis. {ECO:0000269|PubMed:16364915, ECO:0000269|PubMed:17533573, ECO:0000269|PubMed:18678652, ECO:0000269|PubMed:25701870}. |
| Q96N46 | TTC14 | S580 | ochoa | Tetratricopeptide repeat protein 14 (TPR repeat protein 14) | None |
| Q96T58 | SPEN | S1824 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q99504 | EYA3 | S297 | ochoa | Protein phosphatase EYA3 (EC 3.1.3.48) (Eyes absent homolog 3) | Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1 (PubMed:19234442, PubMed:19351884). Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity (By similarity). May be involved in development of the eye. {ECO:0000250|UniProtKB:P97480, ECO:0000269|PubMed:19234442, ECO:0000269|PubMed:19351884}. |
| Q99666 | RGPD5 | S1017 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q99996 | AKAP9 | S43 | psp | A-kinase anchor protein 9 (AKAP-9) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (A-kinase anchor protein 450 kDa) (AKAP 450) (AKAP 120-like protein) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP) (Protein hyperion) (Protein kinase A-anchoring protein 9) (PRKA9) (Protein yotiao) | Scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. Required to maintain the integrity of the Golgi apparatus (PubMed:10202149, PubMed:15047863). Required for microtubule nucleation at the cis-side of the Golgi apparatus (PubMed:15047863, PubMed:19242490). Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase (PubMed:25657325). In complex with PDE4DIP isoform 13/MMG8/SMYLE, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745, PubMed:28814570). In complex with PDE4DIP isoform 13/MMG8/SMYLE, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension also from the centrosome to the cell periphery (PubMed:29162697). {ECO:0000269|PubMed:10202149, ECO:0000269|PubMed:15047863, ECO:0000269|PubMed:19242490, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28814570, ECO:0000269|PubMed:29162697}.; FUNCTION: [Isoform 4]: Associated with the N-methyl-D-aspartate receptor and is specifically found in the neuromuscular junction (NMJ) as well as in neuronal synapses, suggesting a role in the organization of postsynaptic specializations. {ECO:0000269|PubMed:9482789}. |
| Q9BQ70 | TCF25 | S137 | ochoa | Ribosome quality control complex subunit TCF25 (Nuclear localized protein 1) (Transcription factor 25) (TCF-25) | Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed:30244831). In the RQC complex, required to promote formation of 'Lys-48'-linked polyubiquitin chains during ubiquitination of incompletely synthesized proteins by LTN1 (PubMed:30244831). May negatively regulate the calcineurin-NFAT signaling cascade by suppressing the activity of transcription factor NFATC4 (By similarity). May play a role in cell death control (By similarity). {ECO:0000250|UniProtKB:A0A8I6ASZ5, ECO:0000250|UniProtKB:Q8R3L2, ECO:0000269|PubMed:30244831}. |
| Q9BXF6 | RAB11FIP5 | S564 | ochoa | Rab11 family-interacting protein 5 (Rab11-FIP5) (Gamma-SNAP-associated factor 1) (Gaf-1) (Phosphoprotein pp75) (Rab11-interacting protein Rip11) | Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis. {ECO:0000269|PubMed:11163216, ECO:0000269|PubMed:20717956}. |
| Q9BY42 | RTF2 | S207 | ochoa | Replication termination factor 2 (RTF2) (Replication termination factor 2 domain-containing protein 1) | Replication termination factor which is a component of the elongating replisome (Probable). Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion (Probable). Interacts with nascent DNA (PubMed:29290612). {ECO:0000269|PubMed:29290612, ECO:0000305|PubMed:29290612}. |
| Q9BYF1 | ACE2 | S776 | psp | Angiotensin-converting enzyme 2 (EC 3.4.17.23) (Angiotensin-converting enzyme homolog) (ACEH) (Angiotensin-converting enzyme-related carboxypeptidase) (ACE-related carboxypeptidase) (EC 3.4.17.-) (Metalloprotease MPROT15) [Cleaved into: Processed angiotensin-converting enzyme 2] | Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis (PubMed:27217402). Converts angiotensin I to angiotensin 1-9, a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, which then acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II (PubMed:10924499, PubMed:10969042, PubMed:11815627, PubMed:14504186, PubMed:19021774). Also removes the C-terminal residue from three other vasoactive peptides, neurotensin, kinetensin, and des-Arg bradykinin, but is not active on bradykinin (PubMed:10969042, PubMed:11815627). Also cleaves other biological peptides, such as apelins (apelin-13, [Pyr1]apelin-13, apelin-17, apelin-36), casomorphins (beta-casomorphin-7, neocasomorphin) and dynorphin A with high efficiency (PubMed:11815627, PubMed:27217402, PubMed:28293165). In addition, ACE2 C-terminus is homologous to collectrin and is responsible for the trafficking of the neutral amino acid transporter SL6A19 to the plasma membrane of gut epithelial cells via direct interaction, regulating its expression on the cell surface and its catalytic activity (PubMed:18424768, PubMed:19185582). {ECO:0000269|PubMed:10924499, ECO:0000269|PubMed:10969042, ECO:0000269|PubMed:11815627, ECO:0000269|PubMed:14504186, ECO:0000269|PubMed:18424768, ECO:0000269|PubMed:19021774, ECO:0000269|PubMed:19185582, ECO:0000269|PubMed:27217402}.; FUNCTION: (Microbial infection) Acts as a receptor for human coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus NL63/HCoV-NL63. {ECO:0000269|PubMed:14647384, ECO:0000269|PubMed:15452268, ECO:0000269|PubMed:15791205, ECO:0000269|PubMed:15897467, ECO:0000269|PubMed:19901337, ECO:0000269|PubMed:24227843, ECO:0000269|PubMed:32142651, ECO:0000269|PubMed:32221306, ECO:0000269|PubMed:32225175, ECO:0000269|PubMed:33000221, ECO:0000269|PubMed:33082294, ECO:0000269|PubMed:33432067}.; FUNCTION: [Isoform 2]: Non-functional as a carboxypeptidase. {ECO:0000269|PubMed:33077916}.; FUNCTION: [Isoform 2]: (Microbial infection) Non-functional as a receptor for human coronavirus SARS-CoV-2. {ECO:0000269|PubMed:33077916, ECO:0000269|PubMed:33432184}. |
| Q9BYG3 | NIFK | S218 | ochoa | MKI67 FHA domain-interacting nucleolar phosphoprotein (Nucleolar phosphoprotein Nopp34) (Nucleolar protein interacting with the FHA domain of pKI-67) (hNIFK) | None |
| Q9BYW2 | SETD2 | S312 | ochoa | Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) | Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}. |
| Q9BYW2 | SETD2 | S2080 | ochoa | Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) | Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}. |
| Q9C073 | FAM117A | S178 | ochoa | Protein FAM117A (C/EBP-induced protein) | None |
| Q9C0D5 | TANC1 | S22 | ochoa | Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) | May be a scaffold component in the postsynaptic density. {ECO:0000250}. |
| Q9H093 | NUAK2 | S416 | ochoa | NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (Omphalocele kinase 2) (SNF1/AMP kinase-related kinase) (SNARK) | Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Phosphorylates LATS1 and LATS2. Plays a key role in neural tube closure during embryonic development through LATS2 phosphorylation and regulation of the nuclear localization of YAP1 a critical downstream regulatory target in the Hippo signaling pathway (PubMed:32845958). {ECO:0000269|PubMed:14575707, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15345718, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:32845958}. |
| Q9H093 | NUAK2 | S418 | ochoa | NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (Omphalocele kinase 2) (SNF1/AMP kinase-related kinase) (SNARK) | Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Phosphorylates LATS1 and LATS2. Plays a key role in neural tube closure during embryonic development through LATS2 phosphorylation and regulation of the nuclear localization of YAP1 a critical downstream regulatory target in the Hippo signaling pathway (PubMed:32845958). {ECO:0000269|PubMed:14575707, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15345718, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:32845958}. |
| Q9H2Y9 | SLCO5A1 | S385 | ochoa | Solute carrier organic anion transporter family member 5A1 (Organic anion transporter polypeptide-related protein 4) (OATP-RP4) (OATPRP4) (Solute carrier family 21 member 15) | None |
| Q9H792 | PEAK1 | S1368 | ochoa | Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269) | Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:20534451, PubMed:23105102, PubMed:35687021). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654). {ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:23105102, ECO:0000269|PubMed:23846654, ECO:0000269|PubMed:35687021}. |
| Q9H7B2 | RPF2 | S255 | ochoa | Ribosome production factor 2 homolog (Brix domain-containing protein 1) (Ribosome biogenesis protein RPF2 homolog) | Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus. {ECO:0000269|PubMed:24120868}. |
| Q9HCK8 | CHD8 | S549 | ochoa | Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.-) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1) | ATP-dependent chromatin-remodeling factor, it slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. Regulates alternative splicing of a core group of genes involved in neuronal differentiation, cell cycle and DNA repair. Enables H3K36me3-coupled transcription elongation and co-transcriptional RNA processing likely via interaction with HNRNPL. {ECO:0000255|HAMAP-Rule:MF_03071, ECO:0000269|PubMed:17938208, ECO:0000269|PubMed:18378692, ECO:0000269|PubMed:28533432, ECO:0000269|PubMed:36537238}. |
| Q9HCK8 | CHD8 | S1540 | ochoa | Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.-) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1) | ATP-dependent chromatin-remodeling factor, it slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. Regulates alternative splicing of a core group of genes involved in neuronal differentiation, cell cycle and DNA repair. Enables H3K36me3-coupled transcription elongation and co-transcriptional RNA processing likely via interaction with HNRNPL. {ECO:0000255|HAMAP-Rule:MF_03071, ECO:0000269|PubMed:17938208, ECO:0000269|PubMed:18378692, ECO:0000269|PubMed:28533432, ECO:0000269|PubMed:36537238}. |
| Q9HCK8 | CHD8 | S1542 | ochoa | Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.-) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1) | ATP-dependent chromatin-remodeling factor, it slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. Regulates alternative splicing of a core group of genes involved in neuronal differentiation, cell cycle and DNA repair. Enables H3K36me3-coupled transcription elongation and co-transcriptional RNA processing likely via interaction with HNRNPL. {ECO:0000255|HAMAP-Rule:MF_03071, ECO:0000269|PubMed:17938208, ECO:0000269|PubMed:18378692, ECO:0000269|PubMed:28533432, ECO:0000269|PubMed:36537238}. |
| Q9NPF5 | DMAP1 | S41 | ochoa | DNA methyltransferase 1-associated protein 1 (DNMAP1) (DNMT1-associated protein 1) | Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity. {ECO:0000269|PubMed:14665632, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:14978102, ECO:0000269|PubMed:15367675}. |
| Q9NW13 | RBM28 | S200 | ochoa | RNA-binding protein 28 (RNA-binding motif protein 28) | Nucleolar component of the spliceosomal ribonucleoprotein complexes. {ECO:0000269|PubMed:17081119}. |
| Q9NW68 | BSDC1 | S79 | ochoa | BSD domain-containing protein 1 | None |
| Q9NWH9 | SLTM | S590 | ochoa | SAFB-like transcription modulator (Modulator of estrogen-induced transcription) | When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis. {ECO:0000250}. |
| Q9NXL9 | MCM9 | S934 | ochoa | DNA helicase MCM9 (hMCM9) (EC 3.6.4.12) (Mini-chromosome maintenance deficient domain-containing protein 1) (Minichromosome maintenance 9) | Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR) (PubMed:23401855). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity (PubMed:26215093). Probably by regulating the localization of the MRN complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs (PubMed:23401855). Acts as a helicase in DNA mismatch repair (MMR) following DNA replication errors to unwind the mismatch containing DNA strand (PubMed:26300262). In addition, recruits MLH1, a component of the MMR complex, to chromatin (PubMed:26300262). The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression (PubMed:23401855). Probably by regulating HR, plays a key role during gametogenesis (By similarity). {ECO:0000250|UniProtKB:Q2KHI9, ECO:0000269|PubMed:23401855, ECO:0000269|PubMed:26215093, ECO:0000269|PubMed:26300262}. |
| Q9P212 | PLCE1 | S65 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (EC 3.1.4.11) (Pancreas-enriched phospholipase C) (Phosphoinositide phospholipase C-epsilon-1) (Phospholipase C-epsilon-1) (PLC-epsilon-1) | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation. In podocytes, is involved in the regulation of lamellipodia formation. Acts downstream of AVIL to allow ARP2/3 complex assembly (PubMed:29058690). {ECO:0000269|PubMed:11022047, ECO:0000269|PubMed:11395506, ECO:0000269|PubMed:11715024, ECO:0000269|PubMed:11877431, ECO:0000269|PubMed:12721365, ECO:0000269|PubMed:16537651, ECO:0000269|PubMed:17086182, ECO:0000269|PubMed:29058690}. |
| Q9UGU5 | HMGXB4 | S79 | ochoa | HMG domain-containing protein 4 (HMG box-containing protein 4) (High mobility group protein 2-like 1) (Protein HMGBCG) | Negatively regulates Wnt/beta-catenin signaling during development. {ECO:0000250}. |
| Q9UH62 | ARMCX3 | S43 | ochoa | Armadillo repeat-containing X-linked protein 3 (ARM protein lost in epithelial cancers on chromosome X 3) (Protein ALEX3) | Regulates mitochondrial aggregation and transport in axons in living neurons. May link mitochondria to the TRAK2-kinesin motor complex via its interaction with Miro and TRAK2. Mitochondrial distribution and dynamics is regulated through ARMCX3 protein degradation, which is promoted by PCK and negatively regulated by WNT1. Enhances the SOX10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters. {ECO:0000250|UniProtKB:Q8BHS6}. |
| Q9UKJ3 | GPATCH8 | S721 | ochoa | G patch domain-containing protein 8 | None |
| Q9ULX6 | AKAP8L | S283 | ochoa | A-kinase anchor protein 8-like (AKAP8-like protein) (Helicase A-binding protein 95) (HAP95) (Homologous to AKAP95 protein) (HA95) (Neighbor of A-kinase-anchoring protein 95) (Neighbor of AKAP95) | Could play a role in constitutive transport element (CTE)-mediated gene expression by association with DHX9. Increases CTE-dependent nuclear unspliced mRNA export (PubMed:10748171, PubMed:11402034). Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA (PubMed:10761695, PubMed:11884601). May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis (PubMed:11034899). May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta (PubMed:12538639). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function seems to act redundantly with AKAP8 (PubMed:16980585). May be involved in regulation of pre-mRNA splicing (PubMed:17594903). {ECO:0000269|PubMed:10748171, ECO:0000269|PubMed:11034899, ECO:0000269|PubMed:11402034, ECO:0000269|PubMed:11884601, ECO:0000269|PubMed:12538639, ECO:0000269|PubMed:16980585, ECO:0000305|PubMed:10761695}.; FUNCTION: (Microbial infection) In case of EBV infection, may target PRKACA to EBNA-LP-containing nuclear sites to modulate transcription from specific promoters. {ECO:0000269|PubMed:11884601}.; FUNCTION: (Microbial infection) Can synergize with DHX9 to activate the CTE-mediated gene expression of type D retroviruses. {ECO:0000269|PubMed:11402034}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, involved in the DHX9-promoted annealing of host tRNA(Lys3) to viral genomic RNA as a primer in reverse transcription; in vitro negatively regulates DHX9 annealing activity. {ECO:0000269|PubMed:25034436}. |
| Q9UN76 | SLC6A14 | S19 | ochoa | Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) (Amino acid transporter ATB0+) (Solute carrier family 6 member 14) | Amino acid transporter that plays an important role in the absorption of amino acids in the intestinal tract. Mediates the uptake of a broad range of neutral and cationic amino acids (with the exception of proline) in a Na(+)/Cl(-)-dependent manner (PubMed:10446133). Transports non-alpha-amino acids such as beta-alanine with low affinity, and has a higher affinity for dipolar and cationic amino acids such as leucine and lysine (PubMed:18599538). Can also transport carnitine, butirylcarnitine and propionylcarnitine coupled to the transmembrane gradients of Na(+) and Cl(-) (PubMed:17855766). {ECO:0000250|UniProtKB:Q9JMA9, ECO:0000269|PubMed:10446133, ECO:0000269|PubMed:17855766, ECO:0000269|PubMed:18599538}. |
| Q9UQ35 | SRRM2 | S346 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ80 | PA2G4 | S375 | ochoa | Proliferation-associated protein 2G4 (Cell cycle protein p38-2G4 homolog) (hG4-1) (ErbB3-binding protein 1) | May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation (By similarity). {ECO:0000250|UniProtKB:P50580, ECO:0000250|UniProtKB:Q6AYD3, ECO:0000269|PubMed:11268000, ECO:0000269|PubMed:12682367, ECO:0000269|PubMed:15064750, ECO:0000269|PubMed:15583694, ECO:0000269|PubMed:16832058}. |
| Q9Y2W1 | THRAP3 | S377 | ochoa | Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150) | Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). {ECO:0000269|PubMed:20123736, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:22424773, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:24043798}. |
| Q9Y2W1 | THRAP3 | S379 | ochoa | Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150) | Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). {ECO:0000269|PubMed:20123736, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:22424773, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:24043798}. |
| Q9Y4B6 | DCAF1 | S288 | ochoa | DDB1- and CUL4-associated factor 1 (HIV-1 Vpr-binding protein) (VprBP) (Serine/threonine-protein kinase VPRBP) (EC 2.7.11.1) (Vpr-interacting protein) | Acts both as a substrate recognition component of E3 ubiquitin-protein ligase complexes and as an atypical serine/threonine-protein kinase, playing key roles in various processes such as cell cycle, telomerase regulation and histone modification. Probable substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, named CUL4A-RBX1-DDB1-DCAF1/VPRBP complex, which mediates ubiquitination and proteasome-dependent degradation of proteins such as NF2 (PubMed:23063525). Involved in the turnover of methylated proteins: recognizes and binds methylated proteins via its chromo domain, leading to ubiquitination of target proteins by the RBX1-DDB1-DCAF1/VPRBP complex (PubMed:23063525). The CUL4A-RBX1-DDB1-DCAF1/VPRBP complex is also involved in B-cell development: DCAF1 is recruited by RAG1 to ubiquitinate proteins, leading to limit error-prone repair during V(D)J recombination (By similarity). Also part of the EDVP complex, an E3 ligase complex that mediates ubiquitination of proteins such as TERT, leading to TERT degradation and telomerase inhibition (PubMed:19287380, PubMed:23362280). The EDVP complex also mediates ubiquitination and degradation of CCP110 (PubMed:28242748, PubMed:34259627). Also acts as an atypical serine/threonine-protein kinase that specifically mediates phosphorylation of 'Thr-120' of histone H2A (H2AT120ph) in a nucleosomal context, thereby repressing transcription (PubMed:24140421). H2AT120ph is present in the regulatory region of many tumor suppresor genes, down-regulates their transcription and is present at high level in a number of tumors (PubMed:24140421). Involved in JNK-mediated apoptosis during cell competition process via its interaction with LLGL1 and LLGL2 (PubMed:20644714). By acting on TET dioxygenses, essential for oocyte maintenance at the primordial follicle stage, hence essential for female fertility (By similarity). {ECO:0000250|UniProtKB:Q80TR8, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:17609381, ECO:0000269|PubMed:17630831, ECO:0000269|PubMed:18332868, ECO:0000269|PubMed:18524771, ECO:0000269|PubMed:18606781, ECO:0000269|PubMed:19287380, ECO:0000269|PubMed:20644714, ECO:0000269|PubMed:22184063, ECO:0000269|PubMed:23063525, ECO:0000269|PubMed:23362280, ECO:0000269|PubMed:24140421, ECO:0000269|PubMed:28242748, ECO:0000269|PubMed:34259627}.; FUNCTION: (Microbial infection) In case of infection by HIV-1 virus, it is recruited by HIV-1 Vpr in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to arrest the cell cycle in G2 phase, and also to protect the viral protein from proteasomal degradation by another E3 ubiquitin ligase. The HIV-1 Vpr protein hijacks the CUL4A-RBX1-DDB1-DCAF1/VPRBP complex to promote ubiquitination and degradation of proteins such as TERT and ZIP/ZGPAT. {ECO:0000269|PubMed:17314515, ECO:0000269|PubMed:17559673, ECO:0000269|PubMed:17609381, ECO:0000269|PubMed:17620334, ECO:0000269|PubMed:17626091, ECO:0000269|PubMed:17630831, ECO:0000269|PubMed:18524771, ECO:0000269|PubMed:24116224}.; FUNCTION: (Microbial infection) In case of infection by HIV-2 virus, it is recruited by HIV-2 Vpx in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to enhanced efficiency of macrophage infection and promotion of the replication of cognate primate lentiviruses in cells of monocyte/macrophage lineage. {ECO:0000269|PubMed:17314515, ECO:0000269|PubMed:18464893, ECO:0000269|PubMed:19264781, ECO:0000269|PubMed:19923175, ECO:0000269|PubMed:24336198}. |
| Q9Y6R1 | SLC4A4 | S61 | ochoa | Electrogenic sodium bicarbonate cotransporter 1 (Sodium bicarbonate cotransporter) (Na(+)/HCO3(-) cotransporter) (Solute carrier family 4 member 4) (kNBC1) | Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. {ECO:0000269|PubMed:10069984, ECO:0000269|PubMed:11744745, ECO:0000269|PubMed:12411514, ECO:0000269|PubMed:12730338, ECO:0000269|PubMed:12907161, ECO:0000269|PubMed:14567693, ECO:0000269|PubMed:15218065, ECO:0000269|PubMed:15713912, ECO:0000269|PubMed:15817634, ECO:0000269|PubMed:15930088, ECO:0000269|PubMed:16636648, ECO:0000269|PubMed:16769890, ECO:0000269|PubMed:17661077, ECO:0000269|PubMed:23324180, ECO:0000269|PubMed:23636456, ECO:0000269|PubMed:29500354, ECO:0000269|PubMed:9235899, ECO:0000269|PubMed:9651366}. |
| Q9Y6R1 | SLC4A4 | S1026 | ochoa|psp | Electrogenic sodium bicarbonate cotransporter 1 (Sodium bicarbonate cotransporter) (Na(+)/HCO3(-) cotransporter) (Solute carrier family 4 member 4) (kNBC1) | Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. {ECO:0000269|PubMed:10069984, ECO:0000269|PubMed:11744745, ECO:0000269|PubMed:12411514, ECO:0000269|PubMed:12730338, ECO:0000269|PubMed:12907161, ECO:0000269|PubMed:14567693, ECO:0000269|PubMed:15218065, ECO:0000269|PubMed:15713912, ECO:0000269|PubMed:15817634, ECO:0000269|PubMed:15930088, ECO:0000269|PubMed:16636648, ECO:0000269|PubMed:16769890, ECO:0000269|PubMed:17661077, ECO:0000269|PubMed:23324180, ECO:0000269|PubMed:23636456, ECO:0000269|PubMed:29500354, ECO:0000269|PubMed:9235899, ECO:0000269|PubMed:9651366}. |
| Q14247 | CTTN | S209 | Sugiyama | Src substrate cortactin (Amplaxin) (Oncogene EMS1) | Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). {ECO:0000250|UniProtKB:Q60598, ECO:0000250|UniProtKB:Q66HL2, ECO:0000269|PubMed:16636290, ECO:0000269|PubMed:17959782, ECO:0000269|PubMed:21296879, ECO:0000269|PubMed:23144454}. |
| Q6UB35 | MTHFD1L | S401 | Sugiyama | Monofunctional C1-tetrahydrofolate synthase, mitochondrial (EC 6.3.4.3) (Formyltetrahydrofolate synthetase) | May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism complementing thus the enzymatic activities of MTHFD2. {ECO:0000250, ECO:0000269|PubMed:16171773}. |
| Q9UPN9 | TRIM33 | S1015 | Sugiyama | E3 ubiquitin-protein ligase TRIM33 (EC 2.3.2.27) (Ectodermin homolog) (RET-fused gene 7 protein) (Protein Rfg7) (RING-type E3 ubiquitin transferase TRIM33) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) | Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade). {ECO:0000250, ECO:0000269|PubMed:10022127, ECO:0000269|PubMed:15820681, ECO:0000269|PubMed:16751102, ECO:0000269|PubMed:19135894}. |
| Q9NPI1 | BRD7 | Y190 | Sugiyama | Bromodomain-containing protein 7 (75 kDa bromodomain protein) (Protein CELTIX-1) | Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR (By similarity). Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase. {ECO:0000250, ECO:0000269|PubMed:16265664, ECO:0000269|PubMed:16475162, ECO:0000269|PubMed:20215511, ECO:0000269|PubMed:20228809, ECO:0000269|PubMed:20660729}. |
| Q07866 | KLC1 | S445 | Sugiyama | Kinesin light chain 1 (KLC 1) | Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport (PubMed:21385839). The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity). {ECO:0000250|UniProtKB:P37285, ECO:0000269|PubMed:21385839}. |
| O43526 | KCNQ2 | S558 | SIGNOR|iPTMNet|EPSD | Potassium voltage-gated channel subfamily KQT member 2 (KQT-like 2) (Neuroblastoma-specific potassium channel subunit alpha KvLQT2) (Voltage-gated potassium channel subunit Kv7.2) | Pore-forming subunit of the voltage-gated potassium (Kv) M-channel which is responsible for the M-current, a key controller of neuronal excitability (PubMed:24277843, PubMed:28793216, PubMed:9836639). M-channel is composed of pore-forming subunits KCNQ2 and KCNQ3 assembled as heterotetramers (PubMed:10781098, PubMed:14534157, PubMed:32884139, PubMed:37857637, PubMed:9836639). The native M-current has a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs (PubMed:14534157, PubMed:28793216, PubMed:9836639). KCNQ2-KCNQ3 M-channel is selectively permeable in vitro to other cations besides potassium, in decreasing order of affinity K(+) > Rb(+) > Cs(+) > Na(+) (PubMed:28793216). M-channel association with SLC5A3/SMIT1 alters channel ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+) (PubMed:28793216). Suppressed by activation of the muscarinic acetylcholine receptor CHRM1 (PubMed:10684873, PubMed:10713961). {ECO:0000269|PubMed:10684873, ECO:0000269|PubMed:10713961, ECO:0000269|PubMed:10781098, ECO:0000269|PubMed:14534157, ECO:0000269|PubMed:24277843, ECO:0000269|PubMed:28793216, ECO:0000269|PubMed:32884139, ECO:0000269|PubMed:37857637, ECO:0000269|PubMed:9836639}. |
| P33778 | H2BC3 | S33 | EPSD | Histone H2B type 1-B (H2B-clustered histone 3) (Histone H2B.1) (Histone H2B.f) (H2B/f) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| P62807 | H2BC4 | S33 | ELM | Histone H2B type 1-C/E/F/G/I (Histone H2B.1 A) (Histone H2B.a) (H2B/a) (Histone H2B.g) (H2B/g) (Histone H2B.h) (H2B/h) (Histone H2B.k) (H2B/k) (Histone H2B.l) (H2B/l) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| Q00987 | MDM2 | S342 | PSP | E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2) | E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome (PubMed:29681526). Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also a component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (PubMed:12821780, PubMed:15053880, PubMed:15195100, PubMed:15632057, PubMed:16337594, PubMed:17290220, PubMed:19098711, PubMed:19219073, PubMed:19837670, PubMed:19965871, PubMed:20173098, PubMed:20385133, PubMed:20858735, PubMed:22128911). Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (By similarity). Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity). Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis (PubMed:30879903). Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis (PubMed:30879903). {ECO:0000250|UniProtKB:P23804, ECO:0000269|PubMed:12821780, ECO:0000269|PubMed:15053880, ECO:0000269|PubMed:15195100, ECO:0000269|PubMed:15632057, ECO:0000269|PubMed:16337594, ECO:0000269|PubMed:17290220, ECO:0000269|PubMed:19098711, ECO:0000269|PubMed:19219073, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:20173098, ECO:0000269|PubMed:20385133, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:22128911, ECO:0000269|PubMed:29681526, ECO:0000269|PubMed:30879903}. |
| P18859 | ATP5PF | S57 | Sugiyama | ATP synthase peripheral stalk subunit F6, mitochondrial (ATPase subunit F6) (ATP synthase peripheral stalk subunit F6) | Subunit F6, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (PubMed:37244256). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (PubMed:37244256). Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (By similarity). {ECO:0000250|UniProtKB:P02721, ECO:0000250|UniProtKB:P19483, ECO:0000269|PubMed:37244256, ECO:0000305|PubMed:37244256}. |
| P13073 | COX4I1 | S71 | Sugiyama | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (Cytochrome c oxidase polypeptide IV) (Cytochrome c oxidase subunit IV isoform 1) (COX IV-1) | Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P00424}. |
| Q96E11 | MRRF | S227 | Sugiyama | Ribosome-recycling factor, mitochondrial (RRF) (mtRRF) (Ribosome-releasing factor, mitochondrial) | Responsible for the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis (PubMed:19716793, PubMed:33878294). Acts in collaboration with GFM2 (PubMed:33878294). Promotes mitochondrial ribosome recycling by dissolution of intersubunit contacts (PubMed:33878294). {ECO:0000269|PubMed:19716793, ECO:0000269|PubMed:33878294}. |
| Q9UPT8 | ZC3H4 | S131 | Sugiyama | Zinc finger CCCH domain-containing protein 4 | RNA-binding protein that suppresses transcription of long non-coding RNAs (lncRNAs) (PubMed:33767452, PubMed:33913806). LncRNAs are defined as transcripts more than 200 nucleotides that are not translated into protein (PubMed:33767452, PubMed:33913806). Together with WDR82, part of a transcription termination checkpoint that promotes transcription termination of lncRNAs and their subsequent degradation by the exosome (PubMed:33767452, PubMed:33913806). The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs (PubMed:33767452). {ECO:0000269|PubMed:33767452, ECO:0000269|PubMed:33913806}. |
| Q99439 | CNN2 | S138 | Sugiyama | Calponin-2 (Calponin H2, smooth muscle) (Neutral calponin) | Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. |
| Q01081 | U2AF1 | S19 | Sugiyama | Splicing factor U2AF 35 kDa subunit (U2 auxiliary factor 35 kDa subunit) (U2 small nuclear RNA auxiliary factor 1) (U2 snRNP auxiliary factor small subunit) | Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron. {ECO:0000269|PubMed:22158538, ECO:0000269|PubMed:25311244, ECO:0000269|PubMed:8647433}. |
| Q8WU68 | U2AF1L4 | S19 | Sugiyama | Splicing factor U2AF 26 kDa subunit (U2 auxiliary factor 26) (U2 small nuclear RNA auxiliary factor 1-like protein 4) (U2AF1-like 4) (U2(RNU2) small nuclear RNA auxiliary factor 1-like protein 3) (U2 small nuclear RNA auxiliary factor 1-like protein 3) (U2AF1-like protein 3) | RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3'-splice site (By similarity). Shows a preference for AGC or AGA (By similarity). {ECO:0000250|UniProtKB:Q8BGJ9}. |
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| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-3371568 | Attenuation phase | 3.087530e-13 | 12.510 |
| R-HSA-3371571 | HSF1-dependent transactivation | 4.224177e-12 | 11.374 |
| R-HSA-3371511 | HSF1 activation | 3.004708e-12 | 11.522 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 5.482189e-10 | 9.261 |
| R-HSA-3371556 | Cellular response to heat stress | 4.397446e-10 | 9.357 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 9.767196e-06 | 5.010 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 1.532455e-05 | 4.815 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 2.985698e-05 | 4.525 |
| R-HSA-774815 | Nucleosome assembly | 2.985698e-05 | 4.525 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 3.054109e-05 | 4.515 |
| R-HSA-8852135 | Protein ubiquitination | 4.161220e-05 | 4.381 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 4.484097e-05 | 4.348 |
| R-HSA-73864 | RNA Polymerase I Transcription | 5.191613e-05 | 4.285 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 5.902203e-05 | 4.229 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 9.343427e-05 | 4.029 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 9.907758e-05 | 4.004 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 1.860804e-04 | 3.730 |
| R-HSA-2262752 | Cellular responses to stress | 1.792996e-04 | 3.746 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 2.469735e-04 | 3.607 |
| R-HSA-73928 | Depyrimidination | 2.469735e-04 | 3.607 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 2.593981e-04 | 3.586 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 3.158201e-04 | 3.501 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 3.605637e-04 | 3.443 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 4.129928e-04 | 3.384 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 4.273705e-04 | 3.369 |
| R-HSA-8953897 | Cellular responses to stimuli | 4.262677e-04 | 3.370 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 4.572725e-04 | 3.340 |
| R-HSA-171306 | Packaging Of Telomere Ends | 5.146720e-04 | 3.288 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 5.146720e-04 | 3.288 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 5.630896e-04 | 3.249 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 6.062858e-04 | 3.217 |
| R-HSA-5334118 | DNA methylation | 6.403315e-04 | 3.194 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 6.403315e-04 | 3.194 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 6.519203e-04 | 3.186 |
| R-HSA-3214815 | HDACs deacetylate histones | 7.000798e-04 | 3.155 |
| R-HSA-5633007 | Regulation of TP53 Activity | 8.401470e-04 | 3.076 |
| R-HSA-73886 | Chromosome Maintenance | 7.816888e-04 | 3.107 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 8.674875e-04 | 3.062 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 9.818532e-04 | 3.008 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 9.197351e-04 | 3.036 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 9.543810e-04 | 3.020 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 1.079787e-03 | 2.967 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 1.146229e-03 | 2.941 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 1.146229e-03 | 2.941 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 1.259836e-03 | 2.900 |
| R-HSA-9843745 | Adipogenesis | 1.272950e-03 | 2.895 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 1.363602e-03 | 2.865 |
| R-HSA-5693606 | DNA Double Strand Break Response | 1.507741e-03 | 2.822 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 1.482399e-03 | 2.829 |
| R-HSA-3214847 | HATs acetylate histones | 1.433809e-03 | 2.844 |
| R-HSA-110331 | Cleavage of the damaged purine | 1.482399e-03 | 2.829 |
| R-HSA-73927 | Depurination | 1.608224e-03 | 2.794 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 1.909549e-03 | 2.719 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 1.881810e-03 | 2.725 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 1.787137e-03 | 2.748 |
| R-HSA-1251932 | PLCG1 events in ERBB2 signaling | 2.047797e-03 | 2.689 |
| R-HSA-1306955 | GRB7 events in ERBB2 signaling | 2.047797e-03 | 2.689 |
| R-HSA-167161 | HIV Transcription Initiation | 2.186057e-03 | 2.660 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 2.186057e-03 | 2.660 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 2.029995e-03 | 2.693 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 2.186057e-03 | 2.660 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 2.029995e-03 | 2.693 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 1.993345e-03 | 2.700 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 2.522642e-03 | 2.598 |
| R-HSA-9710421 | Defective pyroptosis | 2.522642e-03 | 2.598 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 2.845080e-03 | 2.546 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 2.703580e-03 | 2.568 |
| R-HSA-195721 | Signaling by WNT | 2.822375e-03 | 2.549 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 2.893220e-03 | 2.539 |
| R-HSA-4839726 | Chromatin organization | 3.038095e-03 | 2.517 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 3.050714e-03 | 2.516 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 3.091764e-03 | 2.510 |
| R-HSA-912446 | Meiotic recombination | 4.224990e-03 | 2.374 |
| R-HSA-9645723 | Diseases of programmed cell death | 4.507642e-03 | 2.346 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 4.132651e-03 | 2.384 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 4.509667e-03 | 2.346 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 4.543568e-03 | 2.343 |
| R-HSA-1221632 | Meiotic synapsis | 4.747452e-03 | 2.324 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 4.776068e-03 | 2.321 |
| R-HSA-73884 | Base Excision Repair | 4.906262e-03 | 2.309 |
| R-HSA-74160 | Gene expression (Transcription) | 5.425530e-03 | 2.266 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 6.934708e-03 | 2.159 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 6.752567e-03 | 2.171 |
| R-HSA-157579 | Telomere Maintenance | 7.013263e-03 | 2.154 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 6.914340e-03 | 2.160 |
| R-HSA-3247509 | Chromatin modifying enzymes | 7.231238e-03 | 2.141 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 7.486782e-03 | 2.126 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 7.486782e-03 | 2.126 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 7.486782e-03 | 2.126 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 7.486782e-03 | 2.126 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 7.635799e-03 | 2.117 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 7.635799e-03 | 2.117 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 8.014406e-03 | 2.096 |
| R-HSA-8848021 | Signaling by PTK6 | 8.014406e-03 | 2.096 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 8.422974e-03 | 2.075 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 8.422974e-03 | 2.075 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 1.009231e-02 | 1.996 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 9.223584e-03 | 2.035 |
| R-HSA-167172 | Transcription of the HIV genome | 1.009231e-02 | 1.996 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 8.808149e-03 | 2.055 |
| R-HSA-211000 | Gene Silencing by RNA | 1.036019e-02 | 1.985 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 1.101243e-02 | 1.958 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 1.179961e-02 | 1.928 |
| R-HSA-73857 | RNA Polymerase II Transcription | 1.181359e-02 | 1.928 |
| R-HSA-69620 | Cell Cycle Checkpoints | 1.198396e-02 | 1.921 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 1.198502e-02 | 1.921 |
| R-HSA-1989781 | PPARA activates gene expression | 1.243187e-02 | 1.905 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 1.249131e-02 | 1.903 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 1.283280e-02 | 1.892 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 1.301110e-02 | 1.886 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 1.308760e-02 | 1.883 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 1.355927e-02 | 1.868 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 1.527580e-02 | 1.816 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 1.527580e-02 | 1.816 |
| R-HSA-68875 | Mitotic Prophase | 1.648993e-02 | 1.783 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 1.555999e-02 | 1.808 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 1.703688e-02 | 1.769 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 1.443443e-02 | 1.841 |
| R-HSA-9020591 | Interleukin-12 signaling | 1.409161e-02 | 1.851 |
| R-HSA-977225 | Amyloid fiber formation | 1.703688e-02 | 1.769 |
| R-HSA-446728 | Cell junction organization | 1.744306e-02 | 1.758 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 1.766858e-02 | 1.753 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 1.766858e-02 | 1.753 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 1.796322e-02 | 1.746 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 1.831471e-02 | 1.737 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 1.871804e-02 | 1.728 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 1.897536e-02 | 1.722 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 1.949962e-02 | 1.710 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 1.949962e-02 | 1.710 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 1.949962e-02 | 1.710 |
| R-HSA-1500620 | Meiosis | 1.965062e-02 | 1.707 |
| R-HSA-5689880 | Ub-specific processing proteases | 1.966691e-02 | 1.706 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 1.966691e-02 | 1.706 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 1.966691e-02 | 1.706 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 2.162343e-02 | 1.665 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 2.162343e-02 | 1.665 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 2.162343e-02 | 1.665 |
| R-HSA-5545483 | Defective Mismatch Repair Associated With MLH1 | 2.162343e-02 | 1.665 |
| R-HSA-5632987 | Defective Mismatch Repair Associated With PMS2 | 2.162343e-02 | 1.665 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 2.162343e-02 | 1.665 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 2.162343e-02 | 1.665 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 2.254465e-02 | 1.647 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 2.666388e-02 | 1.574 |
| R-HSA-72187 | mRNA 3'-end processing | 2.870325e-02 | 1.542 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 2.639730e-02 | 1.578 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 2.333223e-02 | 1.632 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 2.720451e-02 | 1.565 |
| R-HSA-9824446 | Viral Infection Pathways | 2.660918e-02 | 1.575 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 2.722247e-02 | 1.565 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 2.479268e-02 | 1.606 |
| R-HSA-447115 | Interleukin-12 family signaling | 2.176480e-02 | 1.662 |
| R-HSA-9609690 | HCMV Early Events | 3.172596e-02 | 1.499 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 3.172596e-02 | 1.499 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 3.205575e-02 | 1.494 |
| R-HSA-5619054 | Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalit... | 3.226015e-02 | 1.491 |
| R-HSA-5674404 | PTEN Loss of Function in Cancer | 3.226015e-02 | 1.491 |
| R-HSA-1500931 | Cell-Cell communication | 3.238705e-02 | 1.490 |
| R-HSA-68886 | M Phase | 3.406237e-02 | 1.468 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 3.444616e-02 | 1.463 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 3.814954e-02 | 1.419 |
| R-HSA-1227986 | Signaling by ERBB2 | 3.925960e-02 | 1.406 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 3.925960e-02 | 1.406 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 3.935494e-02 | 1.405 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 3.935494e-02 | 1.405 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 4.063673e-02 | 1.391 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 4.069987e-02 | 1.390 |
| R-HSA-9707616 | Heme signaling | 4.216658e-02 | 1.375 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 4.278188e-02 | 1.369 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 4.278188e-02 | 1.369 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 4.278188e-02 | 1.369 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 4.278188e-02 | 1.369 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 4.278188e-02 | 1.369 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 4.278188e-02 | 1.369 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 4.278188e-02 | 1.369 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 4.278188e-02 | 1.369 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 4.278188e-02 | 1.369 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 4.278188e-02 | 1.369 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 4.278188e-02 | 1.369 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 5.116544e-02 | 1.291 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 5.116544e-02 | 1.291 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 4.672403e-02 | 1.330 |
| R-HSA-399719 | Trafficking of AMPA receptors | 6.254944e-02 | 1.204 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 6.181868e-02 | 1.209 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 4.361759e-02 | 1.360 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 4.660249e-02 | 1.332 |
| R-HSA-5423599 | Diseases of Mismatch Repair (MMR) | 5.318986e-02 | 1.274 |
| R-HSA-373760 | L1CAM interactions | 5.536530e-02 | 1.257 |
| R-HSA-8939211 | ESR-mediated signaling | 6.434232e-02 | 1.192 |
| R-HSA-73894 | DNA Repair | 5.853309e-02 | 1.233 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 5.289159e-02 | 1.277 |
| R-HSA-162906 | HIV Infection | 5.527380e-02 | 1.257 |
| R-HSA-162587 | HIV Life Cycle | 4.418050e-02 | 1.355 |
| R-HSA-212436 | Generic Transcription Pathway | 5.965804e-02 | 1.224 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 4.365960e-02 | 1.360 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 4.929715e-02 | 1.307 |
| R-HSA-418990 | Adherens junctions interactions | 4.781650e-02 | 1.320 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 4.472231e-02 | 1.349 |
| R-HSA-1592230 | Mitochondrial biogenesis | 5.662530e-02 | 1.247 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 5.116544e-02 | 1.291 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 5.047977e-02 | 1.297 |
| R-HSA-5693538 | Homology Directed Repair | 5.790067e-02 | 1.237 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 6.450685e-02 | 1.190 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 6.853332e-02 | 1.164 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 6.853332e-02 | 1.164 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 6.853332e-02 | 1.164 |
| R-HSA-2559583 | Cellular Senescence | 6.861650e-02 | 1.164 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 7.099409e-02 | 1.149 |
| R-HSA-69481 | G2/M Checkpoints | 7.149094e-02 | 1.146 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 7.366943e-02 | 1.133 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 7.469719e-02 | 1.127 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 7.469719e-02 | 1.127 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 7.484553e-02 | 1.126 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 7.585997e-02 | 1.120 |
| R-HSA-1474165 | Reproduction | 7.734571e-02 | 1.112 |
| R-HSA-9609646 | HCMV Infection | 7.736725e-02 | 1.111 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 7.784332e-02 | 1.109 |
| R-HSA-421270 | Cell-cell junction organization | 7.842685e-02 | 1.106 |
| R-HSA-9909396 | Circadian clock | 8.036087e-02 | 1.095 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 8.103056e-02 | 1.091 |
| R-HSA-5688426 | Deubiquitination | 8.274721e-02 | 1.082 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 8.281939e-02 | 1.082 |
| R-HSA-182218 | Nef Mediated CD8 Down-regulation | 8.374343e-02 | 1.077 |
| R-HSA-5638303 | Inhibition of Signaling by Overexpressed EGFR | 8.374343e-02 | 1.077 |
| R-HSA-5638302 | Signaling by Overexpressed Wild-Type EGFR in Cancer | 8.374343e-02 | 1.077 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 8.425763e-02 | 1.074 |
| R-HSA-68877 | Mitotic Prometaphase | 8.443733e-02 | 1.073 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 8.486795e-02 | 1.071 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 8.486795e-02 | 1.071 |
| R-HSA-162582 | Signal Transduction | 8.614011e-02 | 1.065 |
| R-HSA-8953854 | Metabolism of RNA | 8.739148e-02 | 1.059 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 9.082640e-02 | 1.042 |
| R-HSA-156902 | Peptide chain elongation | 9.114204e-02 | 1.040 |
| R-HSA-9948299 | Ribosome-associated quality control | 9.136495e-02 | 1.039 |
| R-HSA-9734767 | Developmental Cell Lineages | 9.177863e-02 | 1.037 |
| R-HSA-6807070 | PTEN Regulation | 9.299319e-02 | 1.032 |
| R-HSA-8948747 | Regulation of PTEN localization | 1.035658e-01 | 0.985 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 1.035658e-01 | 0.985 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 1.035658e-01 | 0.985 |
| R-HSA-212718 | EGFR interacts with phospholipase C-gamma | 1.133165e-01 | 0.946 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 1.133165e-01 | 0.946 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 1.133165e-01 | 0.946 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 1.325026e-01 | 0.878 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 1.419402e-01 | 0.848 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 1.605104e-01 | 0.794 |
| R-HSA-5619094 | Variant SLC6A14 may confer susceptibility towards obesity | 1.605104e-01 | 0.794 |
| R-HSA-177504 | Retrograde neurotrophin signalling | 1.786809e-01 | 0.748 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 1.876190e-01 | 0.727 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 1.009483e-01 | 0.996 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 1.538905e-01 | 0.813 |
| R-HSA-5674135 | MAP2K and MAPK activation | 1.009483e-01 | 0.996 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 1.113739e-01 | 0.953 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 1.110616e-01 | 0.954 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 1.184594e-01 | 0.926 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 1.184594e-01 | 0.926 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 1.184594e-01 | 0.926 |
| R-HSA-179812 | GRB2 events in EGFR signaling | 1.605104e-01 | 0.794 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 1.043893e-01 | 0.981 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 1.013398e-01 | 0.994 |
| R-HSA-167590 | Nef Mediated CD4 Down-regulation | 1.035658e-01 | 0.985 |
| R-HSA-9733458 | Induction of Cell-Cell Fusion | 1.964603e-01 | 0.707 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 1.227884e-01 | 0.911 |
| R-HSA-6802949 | Signaling by RAS mutants | 1.184594e-01 | 0.926 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 1.920952e-01 | 0.716 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 1.325026e-01 | 0.878 |
| R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 1.325026e-01 | 0.878 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 1.512758e-01 | 0.820 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 1.605104e-01 | 0.794 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 1.786809e-01 | 0.748 |
| R-HSA-9678110 | Attachment and Entry | 1.964603e-01 | 0.707 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 1.403688e-01 | 0.853 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 1.441017e-01 | 0.841 |
| R-HSA-191859 | snRNP Assembly | 1.669045e-01 | 0.778 |
| R-HSA-194441 | Metabolism of non-coding RNA | 1.669045e-01 | 0.778 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 1.064987e-01 | 0.973 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 1.964603e-01 | 0.707 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 1.184594e-01 | 0.926 |
| R-HSA-2467813 | Separation of Sister Chromatids | 1.398962e-01 | 0.854 |
| R-HSA-168330 | Viral RNP Complexes in the Host Cell Nucleus | 1.512758e-01 | 0.820 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 1.246250e-01 | 0.904 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 1.343417e-01 | 0.872 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 1.899493e-01 | 0.721 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 1.324811e-01 | 0.878 |
| R-HSA-5576890 | Phase 3 - rapid repolarisation | 1.035658e-01 | 0.985 |
| R-HSA-425381 | Bicarbonate transporters | 1.419402e-01 | 0.848 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 1.824318e-01 | 0.739 |
| R-HSA-8876725 | Protein methylation | 1.876190e-01 | 0.727 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 1.474989e-01 | 0.831 |
| R-HSA-1640170 | Cell Cycle | 1.762348e-01 | 0.754 |
| R-HSA-1483249 | Inositol phosphate metabolism | 1.552076e-01 | 0.809 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 1.702326e-01 | 0.769 |
| R-HSA-168255 | Influenza Infection | 1.726198e-01 | 0.763 |
| R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 1.035658e-01 | 0.985 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 1.579835e-01 | 0.801 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.950458e-01 | 0.710 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 1.229617e-01 | 0.910 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 1.605104e-01 | 0.794 |
| R-HSA-8983711 | OAS antiviral response | 1.605104e-01 | 0.794 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 1.208606e-01 | 0.918 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 1.424319e-01 | 0.846 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 1.403688e-01 | 0.853 |
| R-HSA-9700206 | Signaling by ALK in cancer | 1.424319e-01 | 0.846 |
| R-HSA-157118 | Signaling by NOTCH | 1.573737e-01 | 0.803 |
| R-HSA-69306 | DNA Replication | 1.190226e-01 | 0.924 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 2.021201e-01 | 0.694 |
| R-HSA-5576893 | Phase 2 - plateau phase | 2.052059e-01 | 0.688 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 2.052059e-01 | 0.688 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 2.054484e-01 | 0.687 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 2.060878e-01 | 0.686 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 2.138569e-01 | 0.670 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 2.138569e-01 | 0.670 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 2.138569e-01 | 0.670 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 2.138569e-01 | 0.670 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 2.138569e-01 | 0.670 |
| R-HSA-5683057 | MAPK family signaling cascades | 2.148153e-01 | 0.668 |
| R-HSA-389948 | Co-inhibition by PD-1 | 2.190654e-01 | 0.659 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 2.220370e-01 | 0.654 |
| R-HSA-180292 | GAB1 signalosome | 2.224143e-01 | 0.653 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 2.224143e-01 | 0.653 |
| R-HSA-5358508 | Mismatch Repair | 2.224143e-01 | 0.653 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 2.224143e-01 | 0.653 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 2.224143e-01 | 0.653 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 2.224143e-01 | 0.653 |
| R-HSA-72766 | Translation | 2.237477e-01 | 0.650 |
| R-HSA-1236394 | Signaling by ERBB4 | 2.260407e-01 | 0.646 |
| R-HSA-72172 | mRNA Splicing | 2.305948e-01 | 0.637 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 2.308791e-01 | 0.637 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 2.308791e-01 | 0.637 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 2.379354e-01 | 0.624 |
| R-HSA-163210 | Formation of ATP by chemiosmotic coupling | 2.392522e-01 | 0.621 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 2.392522e-01 | 0.621 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 2.392522e-01 | 0.621 |
| R-HSA-445144 | Signal transduction by L1 | 2.392522e-01 | 0.621 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 2.421032e-01 | 0.616 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 2.429685e-01 | 0.614 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 2.475346e-01 | 0.606 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 2.475346e-01 | 0.606 |
| R-HSA-9833482 | PKR-mediated signaling | 2.501552e-01 | 0.602 |
| R-HSA-9694614 | Attachment and Entry | 2.557274e-01 | 0.592 |
| R-HSA-2022377 | Metabolism of Angiotensinogen to Angiotensins | 2.557274e-01 | 0.592 |
| R-HSA-68882 | Mitotic Anaphase | 2.588422e-01 | 0.587 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 2.612280e-01 | 0.583 |
| R-HSA-8964038 | LDL clearance | 2.638315e-01 | 0.579 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 2.638315e-01 | 0.579 |
| R-HSA-6798695 | Neutrophil degranulation | 2.695023e-01 | 0.569 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 2.718479e-01 | 0.566 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 2.718479e-01 | 0.566 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 2.718479e-01 | 0.566 |
| R-HSA-9679191 | Potential therapeutics for SARS | 2.788513e-01 | 0.555 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 2.797775e-01 | 0.553 |
| R-HSA-8863678 | Neurodegenerative Diseases | 2.797775e-01 | 0.553 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 2.828818e-01 | 0.548 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 2.876211e-01 | 0.541 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 2.876211e-01 | 0.541 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 2.876211e-01 | 0.541 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 2.936417e-01 | 0.532 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 2.953799e-01 | 0.530 |
| R-HSA-3295583 | TRP channels | 2.953799e-01 | 0.530 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 2.953799e-01 | 0.530 |
| R-HSA-72312 | rRNA processing | 2.974699e-01 | 0.527 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 2.984988e-01 | 0.525 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 2.984988e-01 | 0.525 |
| R-HSA-9610379 | HCMV Late Events | 2.995739e-01 | 0.523 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 3.025149e-01 | 0.519 |
| R-HSA-8949613 | Cristae formation | 3.030546e-01 | 0.518 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 3.030546e-01 | 0.518 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 3.030546e-01 | 0.518 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 3.030546e-01 | 0.518 |
| R-HSA-264876 | Insulin processing | 3.030546e-01 | 0.518 |
| R-HSA-199991 | Membrane Trafficking | 3.103710e-01 | 0.508 |
| R-HSA-9837999 | Mitochondrial protein degradation | 3.145382e-01 | 0.502 |
| R-HSA-180024 | DARPP-32 events | 3.181556e-01 | 0.497 |
| R-HSA-1643685 | Disease | 3.184625e-01 | 0.497 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 3.185364e-01 | 0.497 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 3.225291e-01 | 0.491 |
| R-HSA-72764 | Eukaryotic Translation Termination | 3.225291e-01 | 0.491 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 3.255836e-01 | 0.487 |
| R-HSA-5619102 | SLC transporter disorders | 3.293051e-01 | 0.482 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 3.329311e-01 | 0.478 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 3.329311e-01 | 0.478 |
| R-HSA-182971 | EGFR downregulation | 3.329311e-01 | 0.478 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 3.329311e-01 | 0.478 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 3.401991e-01 | 0.468 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 3.401991e-01 | 0.468 |
| R-HSA-2408557 | Selenocysteine synthesis | 3.463531e-01 | 0.460 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 3.473883e-01 | 0.459 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 3.473883e-01 | 0.459 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 3.473883e-01 | 0.459 |
| R-HSA-9930044 | Nuclear RNA decay | 3.473883e-01 | 0.459 |
| R-HSA-1483255 | PI Metabolism | 3.502986e-01 | 0.456 |
| R-HSA-192823 | Viral mRNA Translation | 3.542361e-01 | 0.451 |
| R-HSA-390522 | Striated Muscle Contraction | 3.544996e-01 | 0.450 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 3.544996e-01 | 0.450 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 3.544996e-01 | 0.450 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 3.544996e-01 | 0.450 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 3.544996e-01 | 0.450 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 3.560549e-01 | 0.448 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 3.565095e-01 | 0.448 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 3.581652e-01 | 0.446 |
| R-HSA-5673000 | RAF activation | 3.615339e-01 | 0.442 |
| R-HSA-180746 | Nuclear import of Rev protein | 3.615339e-01 | 0.442 |
| R-HSA-9833110 | RSV-host interactions | 3.620858e-01 | 0.441 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 3.684919e-01 | 0.434 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 3.684919e-01 | 0.434 |
| R-HSA-2559585 | Oncogene Induced Senescence | 3.684919e-01 | 0.434 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 3.699002e-01 | 0.432 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 3.737934e-01 | 0.427 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 3.753746e-01 | 0.426 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 3.776770e-01 | 0.423 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 3.776770e-01 | 0.423 |
| R-HSA-1296072 | Voltage gated Potassium channels | 3.821826e-01 | 0.418 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 3.821826e-01 | 0.418 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 3.821826e-01 | 0.418 |
| R-HSA-196757 | Metabolism of folate and pterines | 3.821826e-01 | 0.418 |
| R-HSA-9711123 | Cellular response to chemical stress | 3.861213e-01 | 0.413 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 3.889169e-01 | 0.410 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 3.889169e-01 | 0.410 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 3.931098e-01 | 0.405 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 3.931098e-01 | 0.405 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 3.955782e-01 | 0.403 |
| R-HSA-69541 | Stabilization of p53 | 3.955782e-01 | 0.403 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 3.955782e-01 | 0.403 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 3.955782e-01 | 0.403 |
| R-HSA-1266738 | Developmental Biology | 3.992371e-01 | 0.399 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 4.021672e-01 | 0.396 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 4.021672e-01 | 0.396 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 4.021672e-01 | 0.396 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 4.021672e-01 | 0.396 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 4.086849e-01 | 0.389 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 4.086849e-01 | 0.389 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 4.086849e-01 | 0.389 |
| R-HSA-5663205 | Infectious disease | 4.115134e-01 | 0.386 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 4.151319e-01 | 0.382 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 4.151319e-01 | 0.382 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 4.151319e-01 | 0.382 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 4.159298e-01 | 0.381 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 4.159298e-01 | 0.381 |
| R-HSA-2980736 | Peptide hormone metabolism | 4.196921e-01 | 0.377 |
| R-HSA-422475 | Axon guidance | 4.240948e-01 | 0.373 |
| R-HSA-5683826 | Surfactant metabolism | 4.340564e-01 | 0.362 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 4.402283e-01 | 0.356 |
| R-HSA-9679506 | SARS-CoV Infections | 4.418940e-01 | 0.355 |
| R-HSA-2132295 | MHC class II antigen presentation | 4.420024e-01 | 0.355 |
| R-HSA-162909 | Host Interactions of HIV factors | 4.456753e-01 | 0.351 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 4.463333e-01 | 0.350 |
| R-HSA-9675135 | Diseases of DNA repair | 4.463333e-01 | 0.350 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 4.463333e-01 | 0.350 |
| R-HSA-437239 | Recycling pathway of L1 | 4.523721e-01 | 0.345 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 4.523721e-01 | 0.345 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 4.523721e-01 | 0.345 |
| R-HSA-9766229 | Degradation of CDH1 | 4.642538e-01 | 0.333 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 4.642538e-01 | 0.333 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 4.642538e-01 | 0.333 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 4.700982e-01 | 0.328 |
| R-HSA-9864848 | Complex IV assembly | 4.758792e-01 | 0.323 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 4.872537e-01 | 0.312 |
| R-HSA-9675108 | Nervous system development | 4.894475e-01 | 0.310 |
| R-HSA-72649 | Translation initiation complex formation | 4.928485e-01 | 0.307 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 4.928485e-01 | 0.307 |
| R-HSA-392499 | Metabolism of proteins | 4.951295e-01 | 0.305 |
| R-HSA-9012852 | Signaling by NOTCH3 | 4.983827e-01 | 0.302 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 5.038568e-01 | 0.298 |
| R-HSA-177929 | Signaling by EGFR | 5.038568e-01 | 0.298 |
| R-HSA-193648 | NRAGE signals death through JNK | 5.038568e-01 | 0.298 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 5.038568e-01 | 0.298 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 5.038568e-01 | 0.298 |
| R-HSA-75893 | TNF signaling | 5.038568e-01 | 0.298 |
| R-HSA-9764561 | Regulation of CDH1 Function | 5.092715e-01 | 0.293 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 5.092715e-01 | 0.293 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 5.103038e-01 | 0.292 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 5.146275e-01 | 0.289 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 5.146275e-01 | 0.289 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 5.199253e-01 | 0.284 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 5.199253e-01 | 0.284 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 5.228767e-01 | 0.282 |
| R-HSA-983189 | Kinesins | 5.251656e-01 | 0.280 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 5.251656e-01 | 0.280 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 5.303491e-01 | 0.275 |
| R-HSA-6784531 | tRNA processing in the nucleus | 5.354762e-01 | 0.271 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 5.354762e-01 | 0.271 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 5.405478e-01 | 0.267 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 5.405478e-01 | 0.267 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 5.405478e-01 | 0.267 |
| R-HSA-373755 | Semaphorin interactions | 5.405478e-01 | 0.267 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 5.554343e-01 | 0.255 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 5.555279e-01 | 0.255 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 5.555279e-01 | 0.255 |
| R-HSA-5653656 | Vesicle-mediated transport | 5.559955e-01 | 0.255 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 5.600059e-01 | 0.252 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 5.602891e-01 | 0.252 |
| R-HSA-73887 | Death Receptor Signaling | 5.618668e-01 | 0.250 |
| R-HSA-9711097 | Cellular response to starvation | 5.743510e-01 | 0.241 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 5.745396e-01 | 0.241 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 5.752796e-01 | 0.240 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 5.791869e-01 | 0.237 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 5.837838e-01 | 0.234 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 5.837838e-01 | 0.234 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 5.883307e-01 | 0.230 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 5.883307e-01 | 0.230 |
| R-HSA-2408522 | Selenoamino acid metabolism | 5.925915e-01 | 0.227 |
| R-HSA-1226099 | Signaling by FGFR in disease | 5.928283e-01 | 0.227 |
| R-HSA-380287 | Centrosome maturation | 5.972769e-01 | 0.224 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 5.972769e-01 | 0.224 |
| R-HSA-4086400 | PCP/CE pathway | 6.103350e-01 | 0.214 |
| R-HSA-416482 | G alpha (12/13) signalling events | 6.103350e-01 | 0.214 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 6.103350e-01 | 0.214 |
| R-HSA-9659379 | Sensory processing of sound | 6.145935e-01 | 0.211 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 6.273176e-01 | 0.203 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 6.352016e-01 | 0.197 |
| R-HSA-913531 | Interferon Signaling | 6.463817e-01 | 0.190 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 6.508961e-01 | 0.186 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 6.547136e-01 | 0.184 |
| R-HSA-1236974 | ER-Phagosome pathway | 6.584897e-01 | 0.181 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 6.622246e-01 | 0.179 |
| R-HSA-202424 | Downstream TCR signaling | 6.622246e-01 | 0.179 |
| R-HSA-5617833 | Cilium Assembly | 6.674590e-01 | 0.176 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 6.731876e-01 | 0.172 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 6.731876e-01 | 0.172 |
| R-HSA-391251 | Protein folding | 6.731876e-01 | 0.172 |
| R-HSA-2682334 | EPH-Ephrin signaling | 6.731876e-01 | 0.172 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 6.906785e-01 | 0.161 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 6.906785e-01 | 0.161 |
| R-HSA-1296071 | Potassium Channels | 6.906785e-01 | 0.161 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 6.922447e-01 | 0.160 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 6.940634e-01 | 0.159 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 6.940634e-01 | 0.159 |
| R-HSA-376176 | Signaling by ROBO receptors | 6.993793e-01 | 0.155 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 7.007230e-01 | 0.154 |
| R-HSA-70171 | Glycolysis | 7.039985e-01 | 0.152 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 7.072384e-01 | 0.150 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 7.167480e-01 | 0.145 |
| R-HSA-111885 | Opioid Signalling | 7.167480e-01 | 0.145 |
| R-HSA-397014 | Muscle contraction | 7.221813e-01 | 0.141 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 7.221813e-01 | 0.141 |
| R-HSA-8957322 | Metabolism of steroids | 7.276722e-01 | 0.138 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 7.319195e-01 | 0.136 |
| R-HSA-2672351 | Stimuli-sensing channels | 7.319195e-01 | 0.136 |
| R-HSA-5419276 | Mitochondrial translation termination | 7.348555e-01 | 0.134 |
| R-HSA-1280218 | Adaptive Immune System | 7.354866e-01 | 0.133 |
| R-HSA-202403 | TCR signaling | 7.377594e-01 | 0.132 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 7.490623e-01 | 0.125 |
| R-HSA-70326 | Glucose metabolism | 7.625121e-01 | 0.118 |
| R-HSA-114608 | Platelet degranulation | 7.896311e-01 | 0.103 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 7.919381e-01 | 0.101 |
| R-HSA-5576891 | Cardiac conduction | 8.009174e-01 | 0.096 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 8.031013e-01 | 0.095 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 8.031013e-01 | 0.095 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 8.052615e-01 | 0.094 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 8.136689e-01 | 0.090 |
| R-HSA-5368287 | Mitochondrial translation | 8.177362e-01 | 0.087 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 8.203025e-01 | 0.086 |
| R-HSA-597592 | Post-translational protein modification | 8.290392e-01 | 0.081 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 8.367861e-01 | 0.077 |
| R-HSA-69242 | S Phase | 8.385786e-01 | 0.076 |
| R-HSA-166520 | Signaling by NTRKs | 8.385786e-01 | 0.076 |
| R-HSA-9758941 | Gastrulation | 8.403515e-01 | 0.076 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 8.441317e-01 | 0.074 |
| R-HSA-9612973 | Autophagy | 8.522312e-01 | 0.069 |
| R-HSA-9006936 | Signaling by TGFB family members | 8.586206e-01 | 0.066 |
| R-HSA-1483257 | Phospholipid metabolism | 8.605878e-01 | 0.065 |
| R-HSA-72306 | tRNA processing | 8.748097e-01 | 0.058 |
| R-HSA-418555 | G alpha (s) signalling events | 8.761866e-01 | 0.057 |
| R-HSA-611105 | Respiratory electron transport | 8.854127e-01 | 0.053 |
| R-HSA-112315 | Transmission across Chemical Synapses | 8.907840e-01 | 0.050 |
| R-HSA-69275 | G2/M Transition | 8.951223e-01 | 0.048 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 8.974190e-01 | 0.047 |
| R-HSA-983712 | Ion channel transport | 8.985486e-01 | 0.046 |
| R-HSA-112316 | Neuronal System | 9.050081e-01 | 0.043 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.068804e-01 | 0.042 |
| R-HSA-428157 | Sphingolipid metabolism | 9.111759e-01 | 0.040 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 9.121548e-01 | 0.040 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 9.166536e-01 | 0.038 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 9.186971e-01 | 0.037 |
| R-HSA-449147 | Signaling by Interleukins | 9.254538e-01 | 0.034 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.363173e-01 | 0.029 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.444328e-01 | 0.025 |
| R-HSA-416476 | G alpha (q) signalling events | 9.563572e-01 | 0.019 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 9.609538e-01 | 0.017 |
| R-HSA-1474244 | Extracellular matrix organization | 9.793230e-01 | 0.009 |
| R-HSA-168256 | Immune System | 9.809829e-01 | 0.008 |
| R-HSA-168249 | Innate Immune System | 9.830114e-01 | 0.007 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.857048e-01 | 0.006 |
| R-HSA-556833 | Metabolism of lipids | 9.868104e-01 | 0.006 |
| R-HSA-418594 | G alpha (i) signalling events | 9.912716e-01 | 0.004 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.926251e-01 | 0.003 |
| R-HSA-388396 | GPCR downstream signalling | 9.930283e-01 | 0.003 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.933520e-01 | 0.003 |
| R-HSA-109582 | Hemostasis | 9.936380e-01 | 0.003 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.949124e-01 | 0.002 |
| R-HSA-382551 | Transport of small molecules | 9.958054e-01 | 0.002 |
| R-HSA-372790 | Signaling by GPCR | 9.967683e-01 | 0.001 |
| R-HSA-9709957 | Sensory Perception | 9.999994e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999998e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
NDR2 |
0.801 | 0.221 | -3 | 0.827 |
RSK2 |
0.797 | 0.214 | -3 | 0.798 |
CLK3 |
0.796 | 0.203 | 1 | 0.770 |
PIM1 |
0.796 | 0.281 | -3 | 0.792 |
NDR1 |
0.795 | 0.275 | -3 | 0.830 |
PIM3 |
0.793 | 0.191 | -3 | 0.820 |
PRKD2 |
0.791 | 0.215 | -3 | 0.818 |
COT |
0.790 | 0.100 | 2 | 0.792 |
PRKX |
0.790 | 0.269 | -3 | 0.740 |
CAMK1B |
0.788 | 0.241 | -3 | 0.852 |
RSK4 |
0.788 | 0.212 | -3 | 0.767 |
PKACG |
0.787 | 0.221 | -2 | 0.804 |
RSK3 |
0.787 | 0.160 | -3 | 0.796 |
P90RSK |
0.787 | 0.167 | -3 | 0.789 |
P70S6KB |
0.785 | 0.218 | -3 | 0.816 |
PKACB |
0.784 | 0.206 | -2 | 0.737 |
LATS2 |
0.784 | 0.139 | -5 | 0.659 |
AURC |
0.784 | 0.181 | -2 | 0.703 |
PRKD1 |
0.781 | 0.108 | -3 | 0.823 |
PKN3 |
0.781 | 0.145 | -3 | 0.816 |
WNK1 |
0.780 | 0.231 | -2 | 0.819 |
CAMK2A |
0.779 | 0.180 | 2 | 0.818 |
SKMLCK |
0.779 | 0.137 | -2 | 0.816 |
AMPKA1 |
0.779 | 0.235 | -3 | 0.853 |
NUAK2 |
0.779 | 0.164 | -3 | 0.844 |
CLK2 |
0.778 | 0.200 | -3 | 0.789 |
CAMK2B |
0.778 | 0.159 | 2 | 0.784 |
SRPK1 |
0.778 | 0.125 | -3 | 0.764 |
CDC7 |
0.777 | -0.004 | 1 | 0.795 |
CAMK2G |
0.777 | 0.069 | 2 | 0.791 |
AMPKA2 |
0.776 | 0.223 | -3 | 0.839 |
PKN2 |
0.776 | 0.175 | -3 | 0.831 |
MSK1 |
0.776 | 0.138 | -3 | 0.755 |
PRKD3 |
0.776 | 0.178 | -3 | 0.798 |
MOS |
0.776 | 0.049 | 1 | 0.823 |
MAPKAPK2 |
0.776 | 0.139 | -3 | 0.761 |
CDKL1 |
0.775 | 0.092 | -3 | 0.790 |
PIM2 |
0.775 | 0.219 | -3 | 0.784 |
TSSK1 |
0.775 | 0.223 | -3 | 0.872 |
MST4 |
0.775 | 0.151 | 2 | 0.733 |
CAMLCK |
0.775 | 0.151 | -2 | 0.818 |
CAMK2D |
0.774 | 0.097 | -3 | 0.821 |
MAPKAPK3 |
0.774 | 0.142 | -3 | 0.798 |
CLK4 |
0.774 | 0.159 | -3 | 0.796 |
TSSK2 |
0.774 | 0.199 | -5 | 0.715 |
CAMK4 |
0.773 | 0.171 | -3 | 0.828 |
PKCD |
0.773 | 0.151 | 2 | 0.694 |
CDKL5 |
0.773 | 0.100 | -3 | 0.786 |
MTOR |
0.773 | -0.017 | 1 | 0.756 |
PRPK |
0.773 | -0.014 | -1 | 0.848 |
MYLK4 |
0.772 | 0.167 | -2 | 0.763 |
RAF1 |
0.772 | 0.026 | 1 | 0.769 |
MNK1 |
0.772 | 0.210 | -2 | 0.819 |
CLK1 |
0.772 | 0.161 | -3 | 0.800 |
PKACA |
0.772 | 0.185 | -2 | 0.703 |
PAK1 |
0.771 | 0.137 | -2 | 0.756 |
AURB |
0.771 | 0.140 | -2 | 0.695 |
MNK2 |
0.771 | 0.162 | -2 | 0.800 |
PKG2 |
0.771 | 0.181 | -2 | 0.763 |
SRPK2 |
0.771 | 0.114 | -3 | 0.703 |
MELK |
0.771 | 0.204 | -3 | 0.834 |
NIK |
0.771 | 0.193 | -3 | 0.850 |
RIPK3 |
0.770 | 0.073 | 3 | 0.752 |
MSK2 |
0.770 | 0.094 | -3 | 0.740 |
CAMK1G |
0.770 | 0.194 | -3 | 0.785 |
SGK3 |
0.769 | 0.185 | -3 | 0.787 |
AKT2 |
0.769 | 0.170 | -3 | 0.741 |
NLK |
0.769 | 0.037 | 1 | 0.792 |
GCN2 |
0.768 | -0.072 | 2 | 0.724 |
DAPK2 |
0.768 | 0.103 | -3 | 0.840 |
ICK |
0.768 | 0.094 | -3 | 0.813 |
MARK4 |
0.768 | 0.077 | 4 | 0.826 |
CAMK1D |
0.767 | 0.222 | -3 | 0.755 |
NUAK1 |
0.766 | 0.103 | -3 | 0.825 |
PDHK4 |
0.766 | -0.143 | 1 | 0.789 |
IKKB |
0.765 | -0.088 | -2 | 0.671 |
DCAMKL1 |
0.765 | 0.224 | -3 | 0.832 |
TBK1 |
0.765 | -0.050 | 1 | 0.681 |
LATS1 |
0.765 | 0.121 | -3 | 0.819 |
BRSK1 |
0.765 | 0.137 | -3 | 0.820 |
NIM1 |
0.765 | 0.087 | 3 | 0.766 |
ERK5 |
0.764 | 0.013 | 1 | 0.786 |
HUNK |
0.763 | -0.012 | 2 | 0.751 |
PAK3 |
0.763 | 0.079 | -2 | 0.757 |
ATR |
0.762 | -0.030 | 1 | 0.770 |
HIPK4 |
0.762 | 0.024 | 1 | 0.726 |
PAK6 |
0.762 | 0.114 | -2 | 0.687 |
DSTYK |
0.761 | -0.078 | 2 | 0.805 |
BMPR2 |
0.761 | -0.118 | -2 | 0.808 |
ULK2 |
0.761 | -0.098 | 2 | 0.676 |
WNK3 |
0.761 | 0.013 | 1 | 0.747 |
BRSK2 |
0.760 | 0.127 | -3 | 0.833 |
SIK |
0.760 | 0.113 | -3 | 0.796 |
GRK6 |
0.760 | 0.003 | 1 | 0.772 |
CHK1 |
0.760 | 0.128 | -3 | 0.834 |
P70S6K |
0.760 | 0.157 | -3 | 0.740 |
PKCB |
0.759 | 0.107 | 2 | 0.643 |
DCAMKL2 |
0.758 | 0.165 | -3 | 0.853 |
PKCG |
0.758 | 0.094 | 2 | 0.651 |
DRAK1 |
0.758 | 0.111 | 1 | 0.755 |
IKKE |
0.758 | -0.101 | 1 | 0.666 |
AURA |
0.758 | 0.073 | -2 | 0.640 |
KIS |
0.758 | 0.022 | 1 | 0.676 |
TGFBR2 |
0.758 | -0.032 | -2 | 0.734 |
PAK2 |
0.757 | 0.088 | -2 | 0.738 |
DYRK2 |
0.757 | 0.043 | 1 | 0.670 |
QIK |
0.757 | 0.088 | -3 | 0.818 |
RIPK1 |
0.757 | -0.017 | 1 | 0.760 |
TGFBR1 |
0.756 | 0.040 | -2 | 0.749 |
PDHK1 |
0.756 | -0.170 | 1 | 0.765 |
PKCA |
0.756 | 0.076 | 2 | 0.631 |
PKCH |
0.756 | 0.102 | 2 | 0.635 |
MARK3 |
0.755 | 0.109 | 4 | 0.760 |
MRCKA |
0.755 | 0.244 | -3 | 0.789 |
AKT1 |
0.755 | 0.147 | -3 | 0.755 |
MASTL |
0.755 | -0.081 | -2 | 0.742 |
FAM20C |
0.755 | 0.012 | 2 | 0.574 |
IKKA |
0.755 | -0.081 | -2 | 0.655 |
SSTK |
0.755 | 0.216 | 4 | 0.779 |
GRK1 |
0.755 | -0.023 | -2 | 0.690 |
QSK |
0.755 | 0.066 | 4 | 0.794 |
GRK5 |
0.755 | -0.112 | -3 | 0.760 |
BMPR1B |
0.754 | 0.050 | 1 | 0.754 |
PHKG1 |
0.754 | 0.076 | -3 | 0.827 |
SGK1 |
0.754 | 0.172 | -3 | 0.662 |
SRPK3 |
0.754 | 0.054 | -3 | 0.728 |
JNK2 |
0.753 | 0.066 | 1 | 0.613 |
BCKDK |
0.753 | -0.085 | -1 | 0.800 |
CDK7 |
0.753 | 0.035 | 1 | 0.667 |
MRCKB |
0.753 | 0.227 | -3 | 0.787 |
SMMLCK |
0.753 | 0.126 | -3 | 0.816 |
DMPK1 |
0.753 | 0.276 | -3 | 0.810 |
DNAPK |
0.752 | 0.055 | 1 | 0.655 |
PASK |
0.752 | 0.148 | -3 | 0.805 |
CAMK1A |
0.752 | 0.188 | -3 | 0.730 |
DYRK4 |
0.752 | 0.071 | 1 | 0.613 |
ALK4 |
0.752 | 0.027 | -2 | 0.776 |
AKT3 |
0.752 | 0.163 | -3 | 0.678 |
NEK6 |
0.751 | -0.091 | -2 | 0.786 |
PLK1 |
0.751 | -0.008 | -2 | 0.764 |
CDK10 |
0.751 | 0.132 | 1 | 0.643 |
ATM |
0.750 | -0.023 | 1 | 0.709 |
MARK2 |
0.750 | 0.059 | 4 | 0.730 |
NEK7 |
0.750 | -0.148 | -3 | 0.723 |
CHAK2 |
0.750 | -0.042 | -1 | 0.877 |
ULK1 |
0.750 | -0.134 | -3 | 0.718 |
DLK |
0.749 | -0.083 | 1 | 0.765 |
ROCK2 |
0.749 | 0.250 | -3 | 0.808 |
HIPK1 |
0.749 | 0.078 | 1 | 0.694 |
PHKG2 |
0.749 | 0.123 | -3 | 0.845 |
MLK1 |
0.749 | -0.119 | 2 | 0.724 |
PLK3 |
0.748 | 0.006 | 2 | 0.739 |
IRE2 |
0.748 | 0.038 | 2 | 0.643 |
MARK1 |
0.748 | 0.070 | 4 | 0.775 |
ANKRD3 |
0.747 | -0.090 | 1 | 0.802 |
PKR |
0.747 | 0.032 | 1 | 0.764 |
PKCZ |
0.747 | 0.043 | 2 | 0.653 |
IRE1 |
0.747 | 0.003 | 1 | 0.724 |
CDK18 |
0.747 | 0.057 | 1 | 0.610 |
SBK |
0.747 | 0.142 | -3 | 0.651 |
ALK2 |
0.747 | 0.028 | -2 | 0.753 |
DAPK3 |
0.746 | 0.150 | -3 | 0.817 |
CDK8 |
0.746 | -0.014 | 1 | 0.654 |
MLK2 |
0.746 | -0.068 | 2 | 0.708 |
P38A |
0.746 | 0.039 | 1 | 0.697 |
GRK4 |
0.746 | -0.113 | -2 | 0.725 |
HIPK2 |
0.746 | 0.054 | 1 | 0.598 |
SNRK |
0.745 | 0.009 | 2 | 0.603 |
NEK9 |
0.745 | -0.110 | 2 | 0.708 |
DYRK1A |
0.745 | 0.050 | 1 | 0.702 |
DYRK3 |
0.745 | 0.070 | 1 | 0.688 |
MAPKAPK5 |
0.745 | 0.004 | -3 | 0.710 |
DYRK1B |
0.744 | 0.062 | 1 | 0.639 |
JNK3 |
0.744 | 0.020 | 1 | 0.643 |
CRIK |
0.744 | 0.228 | -3 | 0.743 |
CDK14 |
0.744 | 0.081 | 1 | 0.652 |
PKCT |
0.744 | 0.078 | 2 | 0.632 |
GAK |
0.744 | 0.207 | 1 | 0.879 |
MEK1 |
0.743 | -0.087 | 2 | 0.768 |
GRK7 |
0.743 | -0.019 | 1 | 0.713 |
PKCE |
0.743 | 0.139 | 2 | 0.631 |
CDK16 |
0.742 | 0.106 | 1 | 0.573 |
PLK4 |
0.742 | -0.016 | 2 | 0.570 |
DAPK1 |
0.742 | 0.127 | -3 | 0.794 |
WNK4 |
0.741 | 0.062 | -2 | 0.800 |
PKN1 |
0.741 | 0.101 | -3 | 0.762 |
BMPR1A |
0.740 | 0.035 | 1 | 0.731 |
PAK5 |
0.740 | 0.073 | -2 | 0.617 |
MLK3 |
0.740 | -0.070 | 2 | 0.656 |
CDK5 |
0.740 | 0.024 | 1 | 0.684 |
P38B |
0.740 | 0.026 | 1 | 0.628 |
PAK4 |
0.740 | 0.065 | -2 | 0.622 |
BRAF |
0.740 | -0.028 | -4 | 0.360 |
PKCI |
0.739 | 0.084 | 2 | 0.628 |
CHK2 |
0.739 | 0.105 | -3 | 0.708 |
CDK17 |
0.739 | 0.037 | 1 | 0.553 |
CDK19 |
0.739 | -0.018 | 1 | 0.624 |
ACVR2B |
0.739 | -0.033 | -2 | 0.723 |
VRK2 |
0.739 | -0.134 | 1 | 0.812 |
CDK1 |
0.739 | 0.014 | 1 | 0.623 |
ACVR2A |
0.738 | -0.041 | -2 | 0.708 |
NEK2 |
0.737 | -0.063 | 2 | 0.672 |
CDK9 |
0.737 | 0.005 | 1 | 0.652 |
TTBK2 |
0.737 | -0.142 | 2 | 0.578 |
HIPK3 |
0.737 | 0.030 | 1 | 0.686 |
P38G |
0.736 | 0.025 | 1 | 0.546 |
ERK2 |
0.736 | -0.002 | 1 | 0.656 |
MST3 |
0.735 | 0.070 | 2 | 0.730 |
IRAK4 |
0.735 | 0.039 | 1 | 0.737 |
ROCK1 |
0.735 | 0.203 | -3 | 0.792 |
CDK13 |
0.735 | -0.021 | 1 | 0.643 |
YSK4 |
0.735 | -0.121 | 1 | 0.707 |
GRK2 |
0.734 | -0.050 | -2 | 0.635 |
CDK2 |
0.734 | -0.008 | 1 | 0.691 |
PKG1 |
0.734 | 0.121 | -2 | 0.699 |
ERK1 |
0.733 | -0.004 | 1 | 0.626 |
SMG1 |
0.732 | -0.088 | 1 | 0.724 |
CK2A2 |
0.732 | 0.049 | 1 | 0.698 |
GSK3A |
0.732 | 0.033 | 4 | 0.511 |
CDK3 |
0.731 | 0.030 | 1 | 0.576 |
CHAK1 |
0.731 | -0.072 | 2 | 0.618 |
TLK2 |
0.731 | -0.111 | 1 | 0.692 |
MAK |
0.731 | 0.083 | -2 | 0.691 |
GSK3B |
0.730 | 0.018 | 4 | 0.499 |
MLK4 |
0.730 | -0.122 | 2 | 0.638 |
MPSK1 |
0.730 | 0.060 | 1 | 0.796 |
PBK |
0.730 | 0.180 | 1 | 0.837 |
MOK |
0.729 | 0.093 | 1 | 0.710 |
MEKK3 |
0.729 | -0.095 | 1 | 0.738 |
CDK12 |
0.729 | -0.019 | 1 | 0.613 |
PRP4 |
0.728 | -0.034 | -3 | 0.686 |
NEK5 |
0.728 | -0.043 | 1 | 0.777 |
HRI |
0.727 | -0.113 | -2 | 0.761 |
PERK |
0.727 | -0.111 | -2 | 0.744 |
ZAK |
0.726 | -0.093 | 1 | 0.723 |
MEK5 |
0.726 | -0.134 | 2 | 0.730 |
TAO3 |
0.726 | -0.005 | 1 | 0.728 |
LKB1 |
0.725 | -0.010 | -3 | 0.745 |
PDK1 |
0.724 | -0.010 | 1 | 0.759 |
TAO2 |
0.724 | 0.027 | 2 | 0.731 |
MEKK1 |
0.724 | -0.142 | 1 | 0.748 |
BUB1 |
0.724 | 0.107 | -5 | 0.700 |
P38D |
0.723 | 0.006 | 1 | 0.580 |
TLK1 |
0.723 | -0.113 | -2 | 0.742 |
CK1E |
0.723 | -0.076 | -3 | 0.407 |
IRAK1 |
0.722 | -0.108 | -1 | 0.764 |
CK2A1 |
0.722 | 0.038 | 1 | 0.678 |
JNK1 |
0.721 | 0.001 | 1 | 0.603 |
NEK11 |
0.721 | -0.081 | 1 | 0.740 |
PLK2 |
0.721 | -0.018 | -3 | 0.718 |
LOK |
0.721 | 0.080 | -2 | 0.747 |
MEKK2 |
0.721 | -0.125 | 2 | 0.704 |
ERK7 |
0.719 | -0.023 | 2 | 0.435 |
GRK3 |
0.719 | -0.067 | -2 | 0.589 |
MEKK6 |
0.719 | -0.003 | 1 | 0.732 |
PINK1 |
0.719 | -0.166 | 1 | 0.784 |
CDK4 |
0.718 | 0.024 | 1 | 0.599 |
CAMKK2 |
0.717 | -0.084 | -2 | 0.697 |
GCK |
0.717 | -0.010 | 1 | 0.727 |
BIKE |
0.716 | 0.176 | 1 | 0.836 |
HPK1 |
0.716 | 0.022 | 1 | 0.710 |
CDK6 |
0.716 | 0.023 | 1 | 0.640 |
CAMKK1 |
0.716 | -0.124 | -2 | 0.699 |
PDHK3_TYR |
0.716 | 0.183 | 4 | 0.900 |
NEK8 |
0.715 | -0.127 | 2 | 0.705 |
NEK4 |
0.715 | -0.048 | 1 | 0.720 |
CK1A2 |
0.714 | -0.072 | -3 | 0.359 |
TTBK1 |
0.714 | -0.135 | 2 | 0.519 |
NEK1 |
0.714 | 0.009 | 1 | 0.743 |
CK1G1 |
0.714 | -0.104 | -3 | 0.405 |
CK1D |
0.713 | -0.088 | -3 | 0.352 |
MAP3K15 |
0.712 | -0.066 | 1 | 0.713 |
TNIK |
0.711 | -0.014 | 3 | 0.785 |
STK33 |
0.711 | -0.051 | 2 | 0.549 |
LRRK2 |
0.711 | -0.067 | 2 | 0.725 |
SLK |
0.710 | -0.014 | -2 | 0.669 |
MST2 |
0.710 | -0.119 | 1 | 0.731 |
TAK1 |
0.709 | -0.125 | 1 | 0.745 |
KHS1 |
0.708 | 0.011 | 1 | 0.697 |
RIPK2 |
0.708 | -0.143 | 1 | 0.684 |
KHS2 |
0.708 | 0.030 | 1 | 0.710 |
MST1 |
0.708 | -0.052 | 1 | 0.708 |
TESK1_TYR |
0.708 | 0.132 | 3 | 0.836 |
VRK1 |
0.707 | -0.121 | 2 | 0.733 |
HGK |
0.707 | -0.066 | 3 | 0.782 |
EEF2K |
0.707 | -0.073 | 3 | 0.751 |
LIMK2_TYR |
0.706 | 0.168 | -3 | 0.843 |
AAK1 |
0.706 | 0.193 | 1 | 0.765 |
YSK1 |
0.705 | -0.025 | 2 | 0.676 |
MINK |
0.705 | -0.095 | 1 | 0.717 |
PDHK4_TYR |
0.705 | 0.058 | 2 | 0.822 |
MEK2 |
0.703 | -0.160 | 2 | 0.705 |
PKMYT1_TYR |
0.703 | 0.037 | 3 | 0.837 |
MAP2K6_TYR |
0.703 | 0.025 | -1 | 0.873 |
MAP2K4_TYR |
0.702 | -0.011 | -1 | 0.865 |
MAP2K7_TYR |
0.701 | 0.001 | 2 | 0.780 |
BMPR2_TYR |
0.700 | -0.007 | -1 | 0.859 |
DDR1 |
0.699 | 0.089 | 4 | 0.824 |
PINK1_TYR |
0.698 | -0.025 | 1 | 0.785 |
HASPIN |
0.697 | 0.004 | -1 | 0.696 |
EPHA6 |
0.697 | 0.022 | -1 | 0.846 |
PDHK1_TYR |
0.697 | -0.038 | -1 | 0.890 |
NEK3 |
0.696 | -0.101 | 1 | 0.708 |
RET |
0.694 | 0.019 | 1 | 0.732 |
LIMK1_TYR |
0.694 | 0.027 | 2 | 0.733 |
YES1 |
0.693 | 0.045 | -1 | 0.846 |
TTK |
0.693 | -0.059 | -2 | 0.750 |
ASK1 |
0.692 | -0.086 | 1 | 0.705 |
EPHB4 |
0.692 | -0.008 | -1 | 0.822 |
DDR2 |
0.691 | 0.127 | 3 | 0.712 |
TXK |
0.690 | 0.037 | 1 | 0.803 |
OSR1 |
0.689 | -0.102 | 2 | 0.691 |
EPHA4 |
0.689 | -0.008 | 2 | 0.753 |
TYRO3 |
0.689 | -0.047 | 3 | 0.764 |
TAO1 |
0.688 | -0.036 | 1 | 0.658 |
ALPHAK3 |
0.688 | -0.051 | -1 | 0.760 |
TNK2 |
0.687 | 0.022 | 3 | 0.739 |
MST1R |
0.687 | -0.066 | 3 | 0.787 |
FGR |
0.686 | -0.024 | 1 | 0.828 |
YANK3 |
0.686 | -0.070 | 2 | 0.365 |
SRMS |
0.685 | -0.031 | 1 | 0.782 |
ABL2 |
0.684 | -0.037 | -1 | 0.797 |
TNK1 |
0.684 | 0.034 | 3 | 0.765 |
INSRR |
0.683 | -0.028 | 3 | 0.719 |
MYO3B |
0.683 | -0.078 | 2 | 0.682 |
FGFR2 |
0.683 | -0.025 | 3 | 0.765 |
EPHB3 |
0.683 | -0.026 | -1 | 0.808 |
ITK |
0.683 | -0.009 | -1 | 0.787 |
ROS1 |
0.683 | -0.087 | 3 | 0.745 |
EPHB1 |
0.683 | -0.036 | 1 | 0.772 |
JAK3 |
0.682 | -0.070 | 1 | 0.733 |
CSF1R |
0.682 | -0.097 | 3 | 0.781 |
EPHB2 |
0.682 | -0.032 | -1 | 0.801 |
JAK2 |
0.681 | -0.144 | 1 | 0.731 |
AXL |
0.681 | -0.017 | 3 | 0.752 |
FER |
0.680 | -0.103 | 1 | 0.809 |
TYK2 |
0.680 | -0.172 | 1 | 0.729 |
BLK |
0.680 | 0.011 | -1 | 0.836 |
KDR |
0.680 | -0.022 | 3 | 0.745 |
NEK10_TYR |
0.680 | -0.009 | 1 | 0.631 |
MYO3A |
0.679 | -0.103 | 1 | 0.693 |
ABL1 |
0.679 | -0.056 | -1 | 0.790 |
CK1A |
0.679 | -0.113 | -3 | 0.264 |
TEK |
0.678 | -0.028 | 3 | 0.717 |
LCK |
0.678 | -0.025 | -1 | 0.823 |
FYN |
0.678 | 0.010 | -1 | 0.800 |
HCK |
0.677 | -0.081 | -1 | 0.819 |
PTK2B |
0.677 | -0.000 | -1 | 0.767 |
FGFR1 |
0.677 | -0.069 | 3 | 0.744 |
PDGFRB |
0.677 | -0.087 | 3 | 0.774 |
MERTK |
0.676 | -0.054 | 3 | 0.763 |
EPHA7 |
0.674 | -0.043 | 2 | 0.729 |
EPHA3 |
0.674 | -0.054 | 2 | 0.715 |
KIT |
0.674 | -0.106 | 3 | 0.782 |
FLT1 |
0.673 | -0.049 | -1 | 0.816 |
TNNI3K_TYR |
0.673 | -0.036 | 1 | 0.740 |
FLT3 |
0.673 | -0.116 | 3 | 0.765 |
TEC |
0.673 | -0.050 | -1 | 0.721 |
BMX |
0.672 | -0.039 | -1 | 0.692 |
LTK |
0.671 | -0.060 | 3 | 0.745 |
FGFR3 |
0.671 | -0.068 | 3 | 0.738 |
EPHA1 |
0.671 | -0.054 | 3 | 0.735 |
EPHA5 |
0.670 | -0.035 | 2 | 0.746 |
FLT4 |
0.669 | -0.076 | 3 | 0.755 |
NTRK1 |
0.668 | -0.136 | -1 | 0.790 |
MET |
0.668 | -0.107 | 3 | 0.760 |
SRC |
0.667 | -0.038 | -1 | 0.803 |
PTK2 |
0.666 | -0.011 | -1 | 0.769 |
STLK3 |
0.666 | -0.190 | 1 | 0.671 |
BTK |
0.666 | -0.146 | -1 | 0.746 |
LYN |
0.666 | -0.071 | 3 | 0.736 |
PDGFRA |
0.666 | -0.146 | 3 | 0.776 |
JAK1 |
0.665 | -0.126 | 1 | 0.687 |
EPHA8 |
0.664 | -0.067 | -1 | 0.799 |
ALK |
0.664 | -0.121 | 3 | 0.705 |
ERBB2 |
0.663 | -0.128 | 1 | 0.696 |
WEE1_TYR |
0.663 | -0.098 | -1 | 0.729 |
NTRK2 |
0.662 | -0.151 | 3 | 0.735 |
INSR |
0.662 | -0.125 | 3 | 0.706 |
FRK |
0.662 | -0.120 | -1 | 0.826 |
CSK |
0.661 | -0.100 | 2 | 0.730 |
PTK6 |
0.659 | -0.177 | -1 | 0.711 |
MATK |
0.659 | -0.092 | -1 | 0.729 |
NTRK3 |
0.658 | -0.136 | -1 | 0.738 |
EGFR |
0.656 | -0.093 | 1 | 0.617 |
EPHA2 |
0.656 | -0.060 | -1 | 0.748 |
FGFR4 |
0.654 | -0.107 | -1 | 0.749 |
CK1G3 |
0.654 | -0.122 | -3 | 0.220 |
SYK |
0.651 | -0.077 | -1 | 0.751 |
YANK2 |
0.650 | -0.091 | 2 | 0.387 |
IGF1R |
0.649 | -0.107 | 3 | 0.660 |
ERBB4 |
0.647 | -0.074 | 1 | 0.632 |
MUSK |
0.643 | -0.128 | 1 | 0.607 |
CK1G2 |
0.638 | -0.109 | -3 | 0.318 |
FES |
0.631 | -0.139 | -1 | 0.674 |
ZAP70 |
0.624 | -0.098 | -1 | 0.674 |