Motif 816 (n=225)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0G2JPF8 | HNRNPCL4 | S196 | ochoa | Heterogeneous nuclear ribonucleoprotein C like 4 | None |
| A1L390 | PLEKHG3 | S433 | ochoa | Pleckstrin homology domain-containing family G member 3 (PH domain-containing family G member 3) | Plays a role in controlling cell polarity and cell motility by selectively binding newly polymerized actin and activating RAC1 and CDC42 to enhance local actin polymerization. {ECO:0000269|PubMed:27555588}. |
| B2RXH8 | HNRNPCL2 | S196 | ochoa | Heterogeneous nuclear ribonucleoprotein C-like 2 (hnRNP C-like-2) | May play a role in nucleosome assembly by neutralizing basic proteins such as A and B core hnRNPs. {ECO:0000250}. |
| B7ZW38 | HNRNPCL3 | S196 | ochoa | Heterogeneous nuclear ribonucleoprotein C-like 3 | None |
| H0YC42 | None | S115 | ochoa | Tumor protein D52 | None |
| H0YGG7 | None | S22 | ochoa | ADP-ribosylation factor 1 | None |
| H7C0S8 | None | S222 | ochoa | Argininosuccinate lyase (Calcitonin gene-related peptide-receptor component protein) (DNA-directed RNA polymerase III subunit RPC9) | Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues. {ECO:0000256|ARBA:ARBA00043924}.; FUNCTION: Catalyzes the reversible cleavage of L-argininosuccinate to fumarate and L-arginine, an intermediate step reaction in the urea cycle mostly providing for hepatic nitrogen detoxification into excretable urea as well as de novo L-arginine synthesis in nonhepatic tissues. Essential regulator of intracellular and extracellular L-arginine pools. As part of citrulline-nitric oxide cycle, forms tissue-specific multiprotein complexes with argininosuccinate synthase ASS1, transport protein SLC7A1 and nitric oxide synthase NOS1, NOS2 or NOS3, allowing for cell-autonomous L-arginine synthesis while channeling extracellular L-arginine to nitric oxide synthesis pathway. {ECO:0000256|ARBA:ARBA00045522}.; FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. With POLR3H/RPC8 forms a mobile stalk that protrudes from Pol III core and functions primarily in transcription initiation. Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway. {ECO:0000256|ARBA:ARBA00045808}. |
| O00203 | AP3B1 | S750 | ochoa | AP-3 complex subunit beta-1 (Adaptor protein complex AP-3 subunit beta-1) (Adaptor-related protein complex 3 subunit beta-1) (Beta-3A-adaptin) (Clathrin assembly protein complex 3 beta-1 large chain) | Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. {ECO:0000305|PubMed:9151686}. |
| O00267 | SUPT5H | S149 | ochoa | Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein) | Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A (PubMed:10075709, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter (PubMed:10075709, PubMed:10199401, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II (PubMed:16214896). TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme (PubMed:16214896). Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (PubMed:16214896). Following phosphorylation by CDK9, DSIF can also positively regulate transcriptional elongation (PubMed:16427012). Required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat (PubMed:10393184, PubMed:10454543, PubMed:11809800, PubMed:9514752). DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences (PubMed:11112772, PubMed:14701750). {ECO:0000269|PubMed:10075709, ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:10421630, ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10757782, ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11112772, ECO:0000269|PubMed:11553615, ECO:0000269|PubMed:11809800, ECO:0000269|PubMed:12653964, ECO:0000269|PubMed:12718890, ECO:0000269|PubMed:14701750, ECO:0000269|PubMed:15136722, ECO:0000269|PubMed:15380072, ECO:0000269|PubMed:16214896, ECO:0000269|PubMed:16427012, ECO:0000269|PubMed:9450929, ECO:0000269|PubMed:9514752, ECO:0000269|PubMed:9857195}. |
| O14672 | ADAM10 | S436 | psp | Disintegrin and metalloproteinase domain-containing protein 10 (ADAM 10) (EC 3.4.24.81) (CDw156) (Kuzbanian protein homolog) (Mammalian disintegrin-metalloprotease) (CD antigen CD156c) | Transmembrane metalloprotease which mediates the ectodomain shedding of a myriad of transmembrane proteins, including adhesion proteins, growth factor precursors and cytokines being essential for development and tissue homeostasis (PubMed:11786905, PubMed:12475894, PubMed:20592283, PubMed:24990881, PubMed:26686862, PubMed:28600292, PubMed:31792032). Associates with six members of the tetraspanin superfamily TspanC8 which regulate its exit from the endoplasmic reticulum and its substrate selectivity (PubMed:26686862, PubMed:28600292, PubMed:31792032, PubMed:34739841, PubMed:37516108). Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283). Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP) (PubMed:11786905, PubMed:26686862, PubMed:29224781, PubMed:34739841). Contributes to the normal cleavage of the cellular prion protein (PubMed:11477090). Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity (PubMed:12475894). Also controls the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis (By similarity). Required for the development of type 1 transitional B cells into marginal zone B cells, probably by cleaving Notch (By similarity). Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form (PubMed:17557115). Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B (PubMed:19114711, PubMed:21288900). Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (By similarity). Mediates the proteolytic cleavage of IL6R and IL11RA, leading to the release of secreted forms of IL6R and IL11RA (PubMed:26876177). Enhances the cleavage of CHL1 by BACE1 (By similarity). Cleaves NRCAM (By similarity). Cleaves TREM2, resulting in shedding of the TREM2 ectodomain (PubMed:24990881). Involved in the development and maturation of glomerular and coronary vasculature (By similarity). During development of the cochlear organ of Corti, promotes pillar cell separation by forming a ternary complex with CADH1 and EPHA4 and cleaving CADH1 at adherens junctions (By similarity). May regulate the EFNA5-EPHA3 signaling (PubMed:16239146). Regulates leukocyte transmigration as a sheddase for the adherens junction protein VE-cadherin/CDH5 in endothelial cells (PubMed:28600292). {ECO:0000250|UniProtKB:O35598, ECO:0000269|PubMed:11477090, ECO:0000269|PubMed:11786905, ECO:0000269|PubMed:12475894, ECO:0000269|PubMed:16239146, ECO:0000269|PubMed:17557115, ECO:0000269|PubMed:19114711, ECO:0000269|PubMed:20592283, ECO:0000269|PubMed:21288900, ECO:0000269|PubMed:24990881, ECO:0000269|PubMed:26686862, ECO:0000269|PubMed:26876177, ECO:0000269|PubMed:28600292, ECO:0000269|PubMed:29224781, ECO:0000269|PubMed:31792032, ECO:0000269|PubMed:34739841, ECO:0000269|PubMed:37516108}.; FUNCTION: (Microbial infection) Promotes the cytotoxic activity of S.aureus hly by binding to the toxin at zonula adherens and promoting formation of toxin pores. {ECO:0000269|PubMed:20624979, ECO:0000269|PubMed:30463011}. |
| O14775 | GNB5 | S63 | ochoa | Guanine nucleotide-binding protein subunit beta-5 (Gbeta5) (Transducin beta chain 5) | Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, such as RGS7 and RGS9, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (PubMed:27677260). Increases RGS7 GTPase-activating protein (GAP) activity, thereby regulating mood and cognition (By similarity). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (PubMed:27677260). May play an important role in neuronal signaling, including in the parasympathetic, but not sympathetic, control of heart rate (By similarity). {ECO:0000250|UniProtKB:A1L271, ECO:0000250|UniProtKB:P62881, ECO:0000269|PubMed:27677260}. |
| O15213 | WDR46 | S560 | ochoa | WD repeat-containing protein 46 (WD repeat-containing protein BING4) | Scaffold component of the nucleolar structure. Required for localization of DDX21 and NCL to the granular compartment of the nucleolus (PubMed:23848194). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23848194, ECO:0000269|PubMed:34516797}. |
| O15553 | MEFV | S242 | ochoa|psp | Pyrin (Marenostrin) | Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma (PubMed:10807793, PubMed:11468188, PubMed:16037825, PubMed:16785446, PubMed:17431422, PubMed:17964261, PubMed:18577712, PubMed:19109554, PubMed:19584923, PubMed:26347139, PubMed:27030597, PubMed:28835462). Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy (PubMed:16785446, PubMed:17431422, PubMed:26347139). Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18-mediated inflammation (PubMed:16785446, PubMed:17431422, PubMed:26347139). However, it can also have a positive effect in the inflammatory pathway, acting as an innate immune sensor that triggers PYCARD/ASC specks formation, caspase-1 activation, and IL1B and IL18 production (PubMed:16037825, PubMed:27030597, PubMed:28835462). Together with AIM2, also acts as a mediator of pyroptosis, necroptosis and apoptosis (PANoptosis), an integral part of host defense against pathogens, in response to bacterial infection (By similarity). It is required for PSTPIP1-induced PYCARD/ASC oligomerization and inflammasome formation (PubMed:10807793, PubMed:11468188, PubMed:17964261, PubMed:18577712, PubMed:19109554, PubMed:19584923). Recruits PSTPIP1 to inflammasomes, and is required for PSTPIP1 oligomerization (PubMed:10807793, PubMed:11468188, PubMed:17964261, PubMed:18577712, PubMed:19109554, PubMed:19584923). {ECO:0000250|UniProtKB:Q9JJ26, ECO:0000269|PubMed:10807793, ECO:0000269|PubMed:11468188, ECO:0000269|PubMed:16037825, ECO:0000269|PubMed:16785446, ECO:0000269|PubMed:17431422, ECO:0000269|PubMed:17964261, ECO:0000269|PubMed:18577712, ECO:0000269|PubMed:19109554, ECO:0000269|PubMed:19584923, ECO:0000269|PubMed:26347139, ECO:0000269|PubMed:27030597, ECO:0000269|PubMed:28835462}. |
| O43148 | RNMT | S24 | ochoa | mRNA cap guanine-N(7) methyltransferase (EC 2.1.1.56) (RG7MT1) (mRNA (guanine-N(7))-methyltransferase) (mRNA cap methyltransferase) (hCMT1) (hMet) (hcm1p) | Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs (PubMed:10347220, PubMed:11114884, PubMed:22099306, PubMed:27422871, PubMed:9705270, PubMed:9790902). Binds RNA containing 5'-terminal GpppC (PubMed:11114884). {ECO:0000269|PubMed:10347220, ECO:0000269|PubMed:11114884, ECO:0000269|PubMed:22099306, ECO:0000269|PubMed:27422871, ECO:0000269|PubMed:9705270, ECO:0000269|PubMed:9790902}. |
| O43353 | RIPK2 | S485 | ochoa | Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containing IL-1 beta ICE-kinase) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (Tyrosine-protein kinase RIPK2) (EC 2.7.10.2) | Serine/threonine/tyrosine-protein kinase that plays an essential role in modulation of innate and adaptive immune responses (PubMed:14638696, PubMed:17054981, PubMed:21123652, PubMed:28656966, PubMed:9575181, PubMed:9642260). Acts as a key effector of NOD1 and NOD2 signaling pathways: upon activation by bacterial peptidoglycans, NOD1 and NOD2 oligomerize and recruit RIPK2 via CARD-CARD domains, leading to the formation of RIPK2 filaments (PubMed:17054981, PubMed:17562858, PubMed:21123652, PubMed:22607974, PubMed:28656966, PubMed:29452636, PubMed:30026309). Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3, as well as 'Met-1'-linked (linear) polyubiquitination by the LUBAC complex, becoming a scaffolding protein for downstream effectors (PubMed:22607974, PubMed:28545134, PubMed:29452636, PubMed:30026309, PubMed:30279485, PubMed:30478312). 'Met-1'-linked polyubiquitin chains attached to RIPK2 recruit IKBKG/NEMO, which undergoes 'Lys-63'-linked polyubiquitination in a RIPK2-dependent process (PubMed:17562858, PubMed:22607974, PubMed:29452636, PubMed:30026309). 'Lys-63'-linked polyubiquitin chains attached to RIPK2 serve as docking sites for TAB2 and TAB3 and mediate the recruitment of MAP3K7/TAK1 to IKBKG/NEMO, inducing subsequent activation of IKBKB/IKKB (PubMed:18079694). In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:18079694). The protein kinase activity is dispensable for the NOD1 and NOD2 signaling pathways (PubMed:29452636, PubMed:30026309). Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappa-B activation by NOD2 (PubMed:21887730). Also involved in adaptive immunity: plays a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation (PubMed:14638696). Plays a role in the inactivation of RHOA in response to NGFR signaling (PubMed:26646181). {ECO:0000269|PubMed:14638696, ECO:0000269|PubMed:17054981, ECO:0000269|PubMed:17562858, ECO:0000269|PubMed:18079694, ECO:0000269|PubMed:21123652, ECO:0000269|PubMed:21887730, ECO:0000269|PubMed:22607974, ECO:0000269|PubMed:26646181, ECO:0000269|PubMed:28545134, ECO:0000269|PubMed:28656966, ECO:0000269|PubMed:29452636, ECO:0000269|PubMed:30026309, ECO:0000269|PubMed:30279485, ECO:0000269|PubMed:30478312, ECO:0000269|PubMed:9575181, ECO:0000269|PubMed:9642260}. |
| O43829 | ZBTB14 | S132 | ochoa | Zinc finger and BTB domain-containing protein 14 (Zinc finger protein 161 homolog) (Zfp-161) (Zinc finger protein 478) (Zinc finger protein 5 homolog) (ZF5) (Zfp-5) (hZF5) | Transcriptional activator of the dopamine transporter (DAT), binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. Binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. Transcriptional repressor of MYC and thymidine kinase promoters. {ECO:0000269|PubMed:17714511}. |
| O60291 | MGRN1 | S106 | ochoa | E3 ubiquitin-protein ligase MGRN1 (EC 2.3.2.27) (Mahogunin RING finger protein 1) (RING finger protein 156) (RING-type E3 ubiquitin transferase MGRN1) | E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling (By similarity). {ECO:0000250|UniProtKB:Q9D074, ECO:0000269|PubMed:17229889, ECO:0000269|PubMed:19703557, ECO:0000269|PubMed:19737927}. |
| O60812 | HNRNPCL1 | S196 | ochoa | Heterogeneous nuclear ribonucleoprotein C-like 1 (hnRNP C-like-1) (hnRNP core protein C-like 1) | May play a role in nucleosome assembly by neutralizing basic proteins such as A and B core hnRNPs. {ECO:0000250}. |
| O60934 | NBN | S509 | ochoa | Nibrin (Cell cycle regulatory protein p95) (Nijmegen breakage syndrome protein 1) (hNbs1) | Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:10888888, PubMed:15616588, PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:19759395, PubMed:23115235, PubMed:28216226, PubMed:28867292, PubMed:9705271). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (PubMed:19759395, PubMed:28867292, PubMed:9705271). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (PubMed:19759395, PubMed:9705271). The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination (PubMed:19759395, PubMed:28867292, PubMed:9705271). Within the MRN complex, NBN acts as a protein-protein adapter, which specifically recognizes and binds phosphorylated proteins, promoting their recruitment to DNA damage sites (PubMed:12419185, PubMed:15616588, PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890, PubMed:19759395, PubMed:19804756, PubMed:23762398, PubMed:24534091, PubMed:27814491, PubMed:27889449, PubMed:33836577). Recruits MRE11 and RAD50 components of the MRN complex to DSBs in response to DNA damage (PubMed:12419185, PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:24534091, PubMed:26438602). Promotes the recruitment of PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites, activating their functions (PubMed:15064416, PubMed:15616588, PubMed:15790808, PubMed:16622404, PubMed:22464731, PubMed:30952868, PubMed:35076389). Mediates the recruitment of phosphorylated RBBP8/CtIP to DSBs, leading to cooperation between the MRN complex and RBBP8/CtIP to initiate end resection (PubMed:19759395, PubMed:27814491, PubMed:27889449, PubMed:33836577). RBBP8/CtIP specifically promotes the endonuclease activity of the MRN complex to clear DNA ends containing protein adducts (PubMed:27814491, PubMed:27889449, PubMed:30787182, PubMed:33836577). The MRN complex is also required for the processing of R-loops (PubMed:31537797). NBN also functions in telomere length maintenance via its interaction with TERF2: interaction with TERF2 during G1 phase preventing recruitment of DCLRE1B/Apollo to telomeres (PubMed:10888888, PubMed:28216226). NBN also promotes DNA repair choice at dysfunctional telomeres: NBN phosphorylation by CDK2 promotes non-homologous end joining repair at telomeres, while unphosphorylated NBN promotes microhomology-mediated end-joining (MMEJ) repair (PubMed:28216226). Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex (PubMed:23762398). {ECO:0000269|PubMed:10888888, ECO:0000269|PubMed:12419185, ECO:0000269|PubMed:15064416, ECO:0000269|PubMed:15616588, ECO:0000269|PubMed:15790808, ECO:0000269|PubMed:16622404, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:19759395, ECO:0000269|PubMed:19804756, ECO:0000269|PubMed:22464731, ECO:0000269|PubMed:23115235, ECO:0000269|PubMed:23762398, ECO:0000269|PubMed:24534091, ECO:0000269|PubMed:26438602, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:28216226, ECO:0000269|PubMed:28867292, ECO:0000269|PubMed:30787182, ECO:0000269|PubMed:30952868, ECO:0000269|PubMed:31537797, ECO:0000269|PubMed:33836577, ECO:0000269|PubMed:35076389, ECO:0000269|PubMed:9705271}. |
| O75391 | SPAG7 | S202 | ochoa | Sperm-associated antigen 7 | None |
| O75554 | WBP4 | S213 | ochoa | WW domain-binding protein 4 (WBP-4) (Formin-binding protein 21) (WW domain-containing-binding protein 4) | Involved in pre-mRNA splicing as a component of the spliceosome (PubMed:19592703, PubMed:28781166, PubMed:9724750). May play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex (PubMed:9724750). {ECO:0000269|PubMed:19592703, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:9724750}. |
| O75575 | CRCP | S37 | ochoa | DNA-directed RNA polymerase III subunit RPC9 (RNA polymerase III subunit C9) (Calcitonin gene-related peptide-receptor component protein) (CGRP-RCP) (CGRP-receptor component protein) (CGRPRCP) (HsC17) | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:20413673, PubMed:33558764, PubMed:34675218). Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. With POLR3H/RPC8 forms a mobile stalk that protrudes from Pol III core and functions primarily in transcription initiation (By similarity) (PubMed:20413673, PubMed:33558764, PubMed:33558766, PubMed:34675218). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway (PubMed:19609254, PubMed:19631370). {ECO:0000250|UniProtKB:Q9C0Z9, ECO:0000269|PubMed:19609254, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20413673, ECO:0000269|PubMed:33558764, ECO:0000269|PubMed:33558766, ECO:0000269|PubMed:34675218}.; FUNCTION: Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues. {ECO:0000250|UniProtKB:O35427}. |
| O95568 | METTL18 | S36 | ochoa | Histidine protein methyltransferase 1 homolog (EC 2.1.1.85) (Arsenic-transactivated protein 2) (AsTP2) (Methyltransferase-like protein 18) | Protein-L-histidine N-tele-methyltransferase that specifically monomethylates RPL3, thereby regulating translation elongation (PubMed:23349634, PubMed:33693809, PubMed:35674491). Histidine methylation of RPL3 regulates translation elongation by slowing ribosome traversal on tyrosine codons: slower elongation provides enough time for proper folding of synthesized proteins and prevents cellular aggregation of tyrosine-rich proteins (PubMed:35674491). {ECO:0000269|PubMed:23349634, ECO:0000269|PubMed:33693809, ECO:0000269|PubMed:35674491}. |
| O95780 | ZNF682 | S54 | ochoa | Zinc finger protein 682 | May be involved in transcriptional regulation. |
| O95786 | RIGI | S854 | psp | Antiviral innate immune response receptor RIG-I (ATP-dependent RNA helicase DDX58) (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (RNA sensor RIG-I) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I) | Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and pro-inflammatory cytokines (PubMed:15208624, PubMed:15708988, PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:17190814, PubMed:18636086, PubMed:19122199, PubMed:19211564, PubMed:24366338, PubMed:28469175, PubMed:29117565, PubMed:31006531, PubMed:34935440, PubMed:35263596, PubMed:36793726). Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments (PubMed:15208624, PubMed:15708988). The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms (PubMed:28469175, PubMed:31006531). Upon activation, associates with mitochondria antiviral signaling protein (MAVS/IPS1) that activates the IKK-related kinases TBK1 and IKBKE which in turn phosphorylate the interferon regulatory factors IRF3 and IRF7, activating transcription of antiviral immunological genes including the IFN-alpha and IFN-beta interferons (PubMed:28469175, PubMed:31006531). Ligands include 5'-triphosphorylated ssRNAs and dsRNAs but also short dsRNAs (<1 kb in length) (PubMed:15208624, PubMed:15708988, PubMed:19576794, PubMed:19609254, PubMed:21742966). In addition to the 5'-triphosphate moiety, blunt-end base pairing at the 5'-end of the RNA is very essential (PubMed:15208624, PubMed:15708988, PubMed:19576794, PubMed:19609254, PubMed:21742966). Overhangs at the non-triphosphorylated end of the dsRNA RNA have no major impact on its activity (PubMed:15208624, PubMed:15708988, PubMed:19576794, PubMed:19609254, PubMed:21742966). A 3'overhang at the 5'triphosphate end decreases and any 5'overhang at the 5' triphosphate end abolishes its activity (PubMed:15208624, PubMed:15708988, PubMed:19576794, PubMed:19609254, PubMed:21742966). Detects both positive and negative strand RNA viruses including members of the families Paramyxoviridae: Human respiratory syncytial virus and measles virus (MeV), Rhabdoviridae: vesicular stomatitis virus (VSV), Orthomyxoviridae: influenza A and B virus, Flaviviridae: Japanese encephalitis virus (JEV), hepatitis C virus (HCV), dengue virus (DENV) and west Nile virus (WNV) (PubMed:21616437, PubMed:21884169). It also detects rotaviruses and reoviruses (PubMed:21616437, PubMed:21884169). Detects and binds to SARS-CoV-2 RNAs which is inhibited by m6A RNA modifications (Ref.74). Also involved in antiviral signaling in response to viruses containing a dsDNA genome such as Epstein-Barr virus (EBV) (PubMed:19631370). Detects dsRNA produced from non-self dsDNA by RNA polymerase III, such as Epstein-Barr virus-encoded RNAs (EBERs). May play important roles in granulocyte production and differentiation, bacterial phagocytosis and in the regulation of cell migration. {ECO:0000269|PubMed:15208624, ECO:0000269|PubMed:15708988, ECO:0000269|PubMed:16125763, ECO:0000269|PubMed:16127453, ECO:0000269|PubMed:16153868, ECO:0000269|PubMed:17190814, ECO:0000269|PubMed:18636086, ECO:0000269|PubMed:19122199, ECO:0000269|PubMed:19211564, ECO:0000269|PubMed:19576794, ECO:0000269|PubMed:19609254, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:21742966, ECO:0000269|PubMed:24366338, ECO:0000269|PubMed:28469175, ECO:0000269|PubMed:29117565, ECO:0000269|PubMed:31006531, ECO:0000269|PubMed:34935440, ECO:0000269|PubMed:35263596, ECO:0000269|PubMed:36793726, ECO:0000269|Ref.74, ECO:0000303|PubMed:21616437, ECO:0000303|PubMed:21884169}. |
| P00338 | LDHA | S237 | ochoa | L-lactate dehydrogenase A chain (LDH-A) (EC 1.1.1.27) (Cell proliferation-inducing gene 19 protein) (LDH muscle subunit) (LDH-M) (Renal carcinoma antigen NY-REN-59) | Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). {ECO:0000269|PubMed:11276087}. |
| P00915 | CA1 | S51 | ochoa | Carbonic anhydrase 1 (EC 4.2.1.1) (Carbonate dehydratase I) (Carbonic anhydrase B) (CAB) (Carbonic anhydrase I) (CA-I) (Cyanamide hydratase CA1) (EC 4.2.1.69) | Catalyzes the reversible hydration of carbon dioxide (PubMed:10550681, PubMed:16506782, PubMed:16686544, PubMed:16807956, PubMed:17127057, PubMed:17314045, PubMed:17407288, PubMed:18618712, PubMed:19186056, PubMed:19206230). Can hydrate cyanamide to urea (PubMed:10550681). {ECO:0000269|PubMed:10550681, ECO:0000269|PubMed:16506782, ECO:0000269|PubMed:16686544, ECO:0000269|PubMed:16807956, ECO:0000269|PubMed:17127057, ECO:0000269|PubMed:17314045, ECO:0000269|PubMed:17407288, ECO:0000269|PubMed:18618712, ECO:0000269|PubMed:19186056, ECO:0000269|PubMed:19206230}. |
| P00918 | CA2 | S172 | ochoa | Carbonic anhydrase 2 (EC 4.2.1.1) (Carbonate dehydratase II) (Carbonic anhydrase C) (CAC) (Carbonic anhydrase II) (CA-II) (Cyanamide hydratase CA2) (EC 4.2.1.69) | Catalyzes the reversible hydration of carbon dioxide (PubMed:11327835, PubMed:11802772, PubMed:11831900, PubMed:12056894, PubMed:12171926, PubMed:1336460, PubMed:14736236, PubMed:15300855, PubMed:15453828, PubMed:15667203, PubMed:15865431, PubMed:16106378, PubMed:16214338, PubMed:16290146, PubMed:16686544, PubMed:16759856, PubMed:16807956, PubMed:17127057, PubMed:17251017, PubMed:17314045, PubMed:17330962, PubMed:17346964, PubMed:17540563, PubMed:17588751, PubMed:17705204, PubMed:18024029, PubMed:18162396, PubMed:18266323, PubMed:18374572, PubMed:18481843, PubMed:18618712, PubMed:18640037, PubMed:18942852, PubMed:1909891, PubMed:1910042, PubMed:19170619, PubMed:19186056, PubMed:19206230, PubMed:19520834, PubMed:19778001, PubMed:7761440, PubMed:7901850, PubMed:8218160, PubMed:8262987, PubMed:8399159, PubMed:8451242, PubMed:8485129, PubMed:8639494, PubMed:9265618, PubMed:9398308). Can also hydrate cyanamide to urea (PubMed:10550681, PubMed:11015219). Stimulates the chloride-bicarbonate exchange activity of SLC26A6 (PubMed:15990874). Essential for bone resorption and osteoclast differentiation (PubMed:15300855). Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. {ECO:0000269|PubMed:10550681, ECO:0000269|PubMed:11015219, ECO:0000269|PubMed:11327835, ECO:0000269|PubMed:11802772, ECO:0000269|PubMed:11831900, ECO:0000269|PubMed:12056894, ECO:0000269|PubMed:12171926, ECO:0000269|PubMed:1336460, ECO:0000269|PubMed:14736236, ECO:0000269|PubMed:15300855, ECO:0000269|PubMed:15453828, ECO:0000269|PubMed:15667203, ECO:0000269|PubMed:15865431, ECO:0000269|PubMed:15990874, ECO:0000269|PubMed:16106378, ECO:0000269|PubMed:16214338, ECO:0000269|PubMed:16290146, ECO:0000269|PubMed:16686544, ECO:0000269|PubMed:16759856, ECO:0000269|PubMed:16807956, ECO:0000269|PubMed:17127057, ECO:0000269|PubMed:17251017, ECO:0000269|PubMed:17314045, ECO:0000269|PubMed:17330962, ECO:0000269|PubMed:17346964, ECO:0000269|PubMed:17540563, ECO:0000269|PubMed:17588751, ECO:0000269|PubMed:17705204, ECO:0000269|PubMed:18024029, ECO:0000269|PubMed:18162396, ECO:0000269|PubMed:18266323, ECO:0000269|PubMed:18374572, ECO:0000269|PubMed:18481843, ECO:0000269|PubMed:18618712, ECO:0000269|PubMed:18640037, ECO:0000269|PubMed:18942852, ECO:0000269|PubMed:1909891, ECO:0000269|PubMed:1910042, ECO:0000269|PubMed:19170619, ECO:0000269|PubMed:19186056, ECO:0000269|PubMed:19206230, ECO:0000269|PubMed:19520834, ECO:0000269|PubMed:19778001, ECO:0000269|PubMed:7761440, ECO:0000269|PubMed:7901850, ECO:0000269|PubMed:8218160, ECO:0000269|PubMed:8262987, ECO:0000269|PubMed:8399159, ECO:0000269|PubMed:8451242, ECO:0000269|PubMed:8485129, ECO:0000269|PubMed:8639494, ECO:0000269|PubMed:9265618, ECO:0000269|PubMed:9398308}. |
| P02549 | SPTA1 | S1284 | ochoa | Spectrin alpha chain, erythrocytic 1 (Erythroid alpha-spectrin) | Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. |
| P02686 | MBP | S19 | ochoa | Myelin basic protein (MBP) (Myelin A1 protein) (Myelin membrane encephalitogenic protein) | The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. {ECO:0000269|PubMed:8544862}. |
| P02794 | FTH1 | S114 | ochoa | Ferritin heavy chain (Ferritin H subunit) (EC 1.16.3.1) (Cell proliferation-inducing gene 15 protein) [Cleaved into: Ferritin heavy chain, N-terminally processed] | Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity (PubMed:9003196). Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (PubMed:9003196). Also plays a role in delivery of iron to cells (By similarity). Mediates iron uptake in capsule cells of the developing kidney (By similarity). Delivery to lysosomes is mediated by the cargo receptor NCOA4 for autophagic degradation and release of iron (PubMed:24695223, PubMed:26436293). {ECO:0000250|UniProtKB:P09528, ECO:0000269|PubMed:24695223, ECO:0000269|PubMed:26436293, ECO:0000269|PubMed:9003196}. |
| P05093 | CYP17A1 | S258 | psp | Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (17-alpha-hydroxyprogesterone aldolase) (EC 1.14.14.32) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17) (Steroid 17-alpha-monooxygenase) | A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis (PubMed:22266943, PubMed:25301938, PubMed:27339894, PubMed:9452426). Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol (Probable) (PubMed:25301938, PubMed:9452426). Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, dehydroepiandrosterone (DHEA) and androstenedione (PubMed:22266943, PubMed:25301938, PubMed:27339894, PubMed:36640554, PubMed:9452426). Has 16-alpha hydroxylase activity. Catalyzes 16-alpha hydroxylation of 17-alpha hydroxy pregnenolone, followed by the cleavage of the C17-C20 bond to form 16-alpha-hydroxy DHEA (PubMed:36640554). Also 16-alpha hydroxylates androgens, relevant for estriol synthesis (PubMed:25301938, PubMed:27339894). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:22266943, PubMed:25301938, PubMed:27339894, PubMed:9452426). {ECO:0000269|PubMed:22266943, ECO:0000269|PubMed:25301938, ECO:0000269|PubMed:27339894, ECO:0000269|PubMed:36640554, ECO:0000269|PubMed:9452426, ECO:0000305|PubMed:8027220}. |
| P07195 | LDHB | S238 | ochoa | L-lactate dehydrogenase B chain (LDH-B) (EC 1.1.1.27) (LDH heart subunit) (LDH-H) (Renal carcinoma antigen NY-REN-46) | Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). {ECO:0000269|PubMed:27618187}. |
| P07814 | EPRS1 | S944 | ochoa | Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)] | Multifunctional protein which primarily functions within the aminoacyl-tRNA synthetase multienzyme complex, also known as multisynthetase complex. Within the complex it catalyzes the attachment of both L-glutamate and L-proline to their cognate tRNAs in a two-step reaction where the amino acid is first activated by ATP to form a covalent intermediate with AMP. Subsequently, the activated amino acid is transferred to the acceptor end of the cognate tRNA to form L-glutamyl-tRNA(Glu) and L-prolyl-tRNA(Pro) (PubMed:23263184, PubMed:24100331, PubMed:29576217, PubMed:3290852, PubMed:37212275). Upon interferon-gamma stimulation, EPRS1 undergoes phosphorylation, causing its dissociation from the aminoacyl-tRNA synthetase multienzyme complex. It is recruited to form the GAIT complex, which binds to stem loop-containing GAIT elements found in the 3'-UTR of various inflammatory mRNAs, such as ceruloplasmin. The GAIT complex inhibits the translation of these mRNAs, allowing interferon-gamma to redirect the function of EPRS1 from protein synthesis to translation inhibition in specific cell contexts (PubMed:15479637, PubMed:23071094). Furthermore, it can function as a downstream effector in the mTORC1 signaling pathway, by promoting the translocation of SLC27A1 from the cytoplasm to the plasma membrane where it mediates the uptake of long-chain fatty acid by adipocytes. Thereby, EPRS1 also plays a role in fat metabolism and more indirectly influences lifespan (PubMed:28178239). {ECO:0000269|PubMed:15479637, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:28178239, ECO:0000269|PubMed:29576217, ECO:0000269|PubMed:3290852, ECO:0000269|PubMed:37212275}. |
| P07910 | HNRNPC | S209 | ochoa | Heterogeneous nuclear ribonucleoproteins C1/C2 (hnRNP C1/C2) | Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621). May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671). {ECO:0000269|PubMed:12509468, ECO:0000269|PubMed:16010978, ECO:0000269|PubMed:25719671, ECO:0000269|PubMed:7567451, ECO:0000269|PubMed:8264621}. |
| P08684 | CYP3A4 | S259 | psp | Cytochrome P450 3A4 (EC 1.14.14.1) (1,4-cineole 2-exo-monooxygenase) (1,8-cineole 2-exo-monooxygenase) (EC 1.14.14.56) (Albendazole monooxygenase (sulfoxide-forming)) (EC 1.14.14.73) (Albendazole sulfoxidase) (CYPIIIA3) (CYPIIIA4) (Cholesterol 25-hydroxylase) (Cytochrome P450 3A3) (Cytochrome P450 HLp) (Cytochrome P450 NF-25) (Cytochrome P450-PCN1) (Nifedipine oxidase) (Quinine 3-monooxygenase) (EC 1.14.14.55) | A cytochrome P450 monooxygenase involved in the metabolism of sterols, steroid hormones, retinoids and fatty acids (PubMed:10681376, PubMed:11093772, PubMed:11555828, PubMed:12865317, PubMed:14559847, PubMed:15373842, PubMed:15764715, PubMed:19965576, PubMed:20702771, PubMed:21490593, PubMed:21576599). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds (PubMed:12865317, PubMed:14559847, PubMed:15373842, PubMed:15764715, PubMed:21490593, PubMed:21576599, PubMed:2732228). Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C-16 position (PubMed:11555828, PubMed:12865317, PubMed:14559847). Plays a role in the metabolism of androgens, particularly in oxidative deactivation of testosterone (PubMed:15373842, PubMed:15764715, PubMed:22773874, PubMed:2732228). Metabolizes testosterone to less biologically active 2beta- and 6beta-hydroxytestosterones (PubMed:15373842, PubMed:15764715, PubMed:2732228). Contributes to the formation of hydroxycholesterols (oxysterols), particularly A-ring hydroxylated cholesterol at the C-4beta position, and side chain hydroxylated cholesterol at the C-25 position, likely contributing to cholesterol degradation and bile acid biosynthesis (PubMed:21576599). Catalyzes bisallylic hydroxylation of polyunsaturated fatty acids (PUFA) (PubMed:9435160). Catalyzes the epoxidation of double bonds of PUFA with a preference for the last double bond (PubMed:19965576). Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling (PubMed:20702771). Plays a role in the metabolism of retinoids. Displays high catalytic activity for oxidation of all-trans-retinol to all-trans-retinal, a rate-limiting step for the biosynthesis of all-trans-retinoic acid (atRA) (PubMed:10681376). Further metabolizes atRA toward 4-hydroxyretinoate and may play a role in hepatic atRA clearance (PubMed:11093772). Responsible for oxidative metabolism of xenobiotics. Acts as a 2-exo-monooxygenase for plant lipid 1,8-cineole (eucalyptol) (PubMed:11159812). Metabolizes the majority of the administered drugs. Catalyzes sulfoxidation of the anthelmintics albendazole and fenbendazole (PubMed:10759686). Hydroxylates antimalarial drug quinine (PubMed:8968357). Acts as a 1,4-cineole 2-exo-monooxygenase (PubMed:11695850). Also involved in vitamin D catabolism and calcium homeostasis. Catalyzes the inactivation of the active hormone calcitriol (1-alpha,25-dihydroxyvitamin D(3)) (PubMed:29461981). {ECO:0000269|PubMed:10681376, ECO:0000269|PubMed:10759686, ECO:0000269|PubMed:11093772, ECO:0000269|PubMed:11159812, ECO:0000269|PubMed:11555828, ECO:0000269|PubMed:11695850, ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:14559847, ECO:0000269|PubMed:15373842, ECO:0000269|PubMed:15764715, ECO:0000269|PubMed:19965576, ECO:0000269|PubMed:20702771, ECO:0000269|PubMed:21490593, ECO:0000269|PubMed:21576599, ECO:0000269|PubMed:22773874, ECO:0000269|PubMed:2732228, ECO:0000269|PubMed:29461981, ECO:0000269|PubMed:8968357, ECO:0000269|PubMed:9435160}. |
| P09086 | POU2F2 | S26 | ochoa | POU domain, class 2, transcription factor 2 (Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2) (Octamer-binding protein 2) (Oct-2) (Octamer-binding transcription factor 2) (OTF-2) | Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3') (PubMed:2904654, PubMed:7859290). Regulates IL6 expression in B cells with POU2AF1 (By similarity). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression (PubMed:2901913, PubMed:2904654). Modulates transcription transactivation by NR3C1, AR and PGR (PubMed:10480874). {ECO:0000250|UniProtKB:Q00196, ECO:0000269|PubMed:10480874, ECO:0000269|PubMed:2328728, ECO:0000269|PubMed:2901913, ECO:0000269|PubMed:2904654, ECO:0000269|PubMed:7859290}.; FUNCTION: [Isoform 5]: Activates the U2 small nuclear RNA (snRNA) promoter. {ECO:0000269|PubMed:1739980}. |
| P09874 | PARP1 | S274 | ochoa | Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)] | Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:17177976, PubMed:18055453, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:20388712, PubMed:21680843, PubMed:22582261, PubMed:23230272, PubMed:25043379, PubMed:26344098, PubMed:26626479, PubMed:26626480, PubMed:30104678, PubMed:31796734, PubMed:32028527, PubMed:32241924, PubMed:32358582, PubMed:33186521, PubMed:34465625, PubMed:34737271). Mediates glutamate, aspartate, serine, histidine or tyrosine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:19764761, PubMed:25043379, PubMed:28190768, PubMed:29954836, PubMed:35393539, PubMed:7852410, PubMed:9315851). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:33186521, PubMed:34874266). Specificity for the different amino acids is conferred by interacting factors, such as HPF1 and NMNAT1 (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 confers serine specificity by completing the PARP1 active site (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Also catalyzes tyrosine ADP-ribosylation of target proteins following interaction with HPF1 (PubMed:29954836, PubMed:30257210). Following interaction with NMNAT1, catalyzes glutamate and aspartate ADP-ribosylation of target proteins; NMNAT1 confers glutamate and aspartate specificity (By similarity). PARP1 initiates the repair of DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones (H2BS6ADPr and H3S10ADPr), thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272, PubMed:27067600, PubMed:34465625, PubMed:34874266). HPF1 initiates serine ADP-ribosylation but restricts the polymerase activity of PARP1 in order to limit the length of poly-ADP-ribose chains (PubMed:33683197, PubMed:34732825, PubMed:34795260). In addition to base excision repair (BER) pathway, also involved in double-strand breaks (DSBs) repair: together with TIMELESS, accumulates at DNA damage sites and promotes homologous recombination repair by mediating poly-ADP-ribosylation (PubMed:26344098, PubMed:30356214). Mediates the poly-ADP-ribosylation of a number of proteins, including itself, APLF, CHFR, RPA1 and NFAT5 (PubMed:17396150, PubMed:19764761, PubMed:24906880, PubMed:34049076). In addition to proteins, also able to ADP-ribosylate DNA: catalyzes ADP-ribosylation of DNA strand break termini containing terminal phosphates and a 2'-OH group in single- and double-stranded DNA, respectively (PubMed:27471034). Required for PARP9 and DTX3L recruitment to DNA damage sites (PubMed:23230272). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). PARP1-mediated DNA repair in neurons plays a role in sleep: senses DNA damage in neurons and promotes sleep, facilitating efficient DNA repair (By similarity). In addition to DNA repair, also involved in other processes, such as transcription regulation, programmed cell death, membrane repair, adipogenesis and innate immunity (PubMed:15607977, PubMed:17177976, PubMed:19344625, PubMed:27256882, PubMed:32315358, PubMed:32844745, PubMed:35124853, PubMed:35393539, PubMed:35460603). Acts as a repressor of transcription: binds to nucleosomes and modulates chromatin structure in a manner similar to histone H1, thereby altering RNA polymerase II (PubMed:15607977, PubMed:22464733). Acts both as a positive and negative regulator of transcription elongation, depending on the context (PubMed:27256882, PubMed:35393539). Acts as a positive regulator of transcription elongation by mediating poly-ADP-ribosylation of NELFE, preventing RNA-binding activity of NELFE and relieving transcription pausing (PubMed:27256882). Acts as a negative regulator of transcription elongation in response to DNA damage by catalyzing poly-ADP-ribosylation of CCNT1, disrupting the phase separation activity of CCNT1 and subsequent activation of CDK9 (PubMed:35393539). Involved in replication fork progression following interaction with CARM1: mediates poly-ADP-ribosylation at replication forks, slowing fork progression (PubMed:33412112). Poly-ADP-ribose chains generated by PARP1 also play a role in poly-ADP-ribose-dependent cell death, a process named parthanatos (By similarity). Also acts as a negative regulator of the cGAS-STING pathway (PubMed:32315358, PubMed:32844745, PubMed:35460603). Acts by mediating poly-ADP-ribosylation of CGAS: PARP1 translocates into the cytosol following phosphorylation by PRKDC and catalyzes poly-ADP-ribosylation and inactivation of CGAS (PubMed:35460603). Acts as a negative regulator of adipogenesis: catalyzes poly-ADP-ribosylation of histone H2B on 'Glu-35' (H2BE35ADPr) following interaction with NMNAT1, inhibiting phosphorylation of H2B at 'Ser-36' (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (By similarity). Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000250|UniProtKB:P11103, ECO:0000269|PubMed:15607977, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:17396150, ECO:0000269|PubMed:18055453, ECO:0000269|PubMed:18172500, ECO:0000269|PubMed:19344625, ECO:0000269|PubMed:19661379, ECO:0000269|PubMed:19764761, ECO:0000269|PubMed:20388712, ECO:0000269|PubMed:21680843, ECO:0000269|PubMed:22464733, ECO:0000269|PubMed:22582261, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:24906880, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:26344098, ECO:0000269|PubMed:26626479, ECO:0000269|PubMed:26626480, ECO:0000269|PubMed:27067600, ECO:0000269|PubMed:27256882, ECO:0000269|PubMed:27257257, ECO:0000269|PubMed:27471034, ECO:0000269|PubMed:28190768, ECO:0000269|PubMed:29954836, ECO:0000269|PubMed:30104678, ECO:0000269|PubMed:30257210, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:31796734, ECO:0000269|PubMed:32028527, ECO:0000269|PubMed:32241924, ECO:0000269|PubMed:32315358, ECO:0000269|PubMed:32358582, ECO:0000269|PubMed:32844745, ECO:0000269|PubMed:33186521, ECO:0000269|PubMed:33412112, ECO:0000269|PubMed:33589610, ECO:0000269|PubMed:33683197, ECO:0000269|PubMed:34049076, ECO:0000269|PubMed:34465625, ECO:0000269|PubMed:34625544, ECO:0000269|PubMed:34732825, ECO:0000269|PubMed:34737271, ECO:0000269|PubMed:34795260, ECO:0000269|PubMed:34874266, ECO:0000269|PubMed:35124853, ECO:0000269|PubMed:35393539, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:7852410, ECO:0000269|PubMed:9315851}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed C-terminus]: Promotes AIFM1-mediated apoptosis (PubMed:33168626). This form, which translocates into the cytoplasm following cleavage by caspase-3 (CASP3) and caspase-7 (CASP7) in response to apoptosis, is auto-poly-ADP-ribosylated and serves as a poly-ADP-ribose carrier to induce AIFM1-mediated apoptosis (PubMed:33168626). {ECO:0000269|PubMed:33168626}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed N-terminus]: This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis. {ECO:0000269|PubMed:35104452}. |
| P0DMR1 | HNRNPCL4 | S196 | ochoa | Heterogeneous nuclear ribonucleoprotein C-like 4 | None |
| P10412 | H1-4 | S102 | ochoa | Histone H1.4 (Histone H1b) (Histone H1s-4) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P10599 | TXN | S44 | ochoa | Thioredoxin (Trx) (ATL-derived factor) (ADF) (Surface-associated sulphydryl protein) (SASP) (allergen Hom s Trx) | Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (PubMed:17182577, PubMed:19032234, PubMed:2176490). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity (PubMed:16408020, PubMed:17606900). Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity (PubMed:11118054, PubMed:9108029). {ECO:0000269|PubMed:11118054, ECO:0000269|PubMed:16408020, ECO:0000269|PubMed:17182577, ECO:0000269|PubMed:17606900, ECO:0000269|PubMed:19032234, ECO:0000269|PubMed:2176490, ECO:0000269|PubMed:9108029}.; FUNCTION: ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55). |
| P10809 | HSPD1 | S410 | ochoa | 60 kDa heat shock protein, mitochondrial (EC 5.6.1.7) (60 kDa chaperonin) (Chaperonin 60) (CPN60) (Heat shock protein 60) (HSP-60) (Hsp60) (Heat shock protein family D member 1) (HuCHA60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) | Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:11422376, PubMed:1346131). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). {ECO:0000269|PubMed:11422376, ECO:0000269|PubMed:1346131, ECO:0000305|PubMed:25918392}. |
| P11021 | HSPA5 | S86 | ochoa | Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein) | Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (PubMed:2294010, PubMed:23769672, PubMed:23990668, PubMed:28332555). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the EIF2AK3/PERK and ERN1/IRE1-mediated unfolded protein response (UPR) (PubMed:11907036, PubMed:1550958, PubMed:19538957, PubMed:36739529). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1 (By similarity). Also binds and inactivates EIF2AK3/PERK in unstressed cells (PubMed:11907036). Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1 and EIF2AK3/PERK, allowing their homodimerization and subsequent activation (PubMed:11907036). Plays an auxiliary role in post-translational transport of small presecretory proteins across endoplasmic reticulum (ER). May function as an allosteric modulator for SEC61 channel-forming translocon complex, likely cooperating with SEC62 to enable the productive insertion of these precursors into SEC61 channel. Appears to specifically regulate translocation of precursors having inhibitory residues in their mature region that weaken channel gating. May also play a role in apoptosis and cell proliferation (PubMed:26045166). {ECO:0000250|UniProtKB:G3I8R9, ECO:0000250|UniProtKB:P20029, ECO:0000269|PubMed:11907036, ECO:0000269|PubMed:1550958, ECO:0000269|PubMed:19538957, ECO:0000269|PubMed:2294010, ECO:0000269|PubMed:23769672, ECO:0000269|PubMed:23990668, ECO:0000269|PubMed:26045166, ECO:0000269|PubMed:28332555, ECO:0000269|PubMed:29719251, ECO:0000269|PubMed:36739529}.; FUNCTION: (Microbial infection) Plays an important role in viral binding to the host cell membrane and entry for several flaviruses such as Dengue virus, Zika virus and Japanese encephalitis virus (PubMed:15098107, PubMed:28053106, PubMed:33432092). Acts as a component of the cellular receptor for Dengue virus serotype 2/DENV-2 on human liver cells (PubMed:15098107). {ECO:0000269|PubMed:15098107, ECO:0000269|PubMed:28053106, ECO:0000269|PubMed:33432092}.; FUNCTION: (Microbial infection) Acts as a receptor for CotH proteins expressed by fungi of the order mucorales, the causative agent of mucormycosis, which plays an important role in epithelial cell invasion by the fungi (PubMed:20484814, PubMed:24355926, PubMed:32487760). Acts as a receptor for R.delemar CotH3 in nasal epithelial cells, which may be an early step in rhinoorbital/cerebral mucormycosis (RCM) disease progression (PubMed:32487760). {ECO:0000269|PubMed:20484814, ECO:0000269|PubMed:24355926, ECO:0000269|PubMed:32487760}. |
| P11055 | MYH3 | S1200 | ochoa | Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE) | Muscle contraction. |
| P12757 | SKIL | S75 | ochoa | Ski-like protein (Ski-related oncogene) (Ski-related protein) | May have regulatory role in cell division or differentiation in response to extracellular signals. |
| P12757 | SKIL | S492 | ochoa | Ski-like protein (Ski-related oncogene) (Ski-related protein) | May have regulatory role in cell division or differentiation in response to extracellular signals. |
| P12882 | MYH1 | S1203 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12883 | MYH7 | S1199 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P13533 | MYH6 | S1201 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P13804 | ETFA | S192 | ochoa | Electron transfer flavoprotein subunit alpha, mitochondrial (Alpha-ETF) | Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase (PubMed:10356313, PubMed:15159392, PubMed:15975918, PubMed:27499296, PubMed:9334218). It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (PubMed:9334218). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism (PubMed:12815589, PubMed:1430199, PubMed:1882842). {ECO:0000269|PubMed:10356313, ECO:0000269|PubMed:12815589, ECO:0000269|PubMed:1430199, ECO:0000269|PubMed:15159392, ECO:0000269|PubMed:15975918, ECO:0000269|PubMed:27499296, ECO:0000269|PubMed:9334218, ECO:0000303|PubMed:17941859, ECO:0000305|PubMed:1882842}. |
| P15498 | VAV1 | S756 | ochoa | Proto-oncogene vav | Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation. |
| P15924 | DSP | S1078 | ochoa | Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) | Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). {ECO:0000250|UniProtKB:F1LMV6}. |
| P16401 | H1-5 | S105 | ochoa | Histone H1.5 (Histone H1a) (Histone H1b) (Histone H1s-3) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P16402 | H1-3 | S103 | ochoa | Histone H1.3 (Histone H1c) (Histone H1s-2) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P16403 | H1-2 | S102 | ochoa | Histone H1.2 (Histone H1c) (Histone H1d) (Histone H1s-1) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P16949 | STMN1 | S46 | ochoa | Stathmin (Leukemia-associated phosphoprotein p18) (Metablastin) (Oncoprotein 18) (Op18) (Phosphoprotein p19) (pp19) (Prosolin) (Protein Pr22) (pp17) | Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity). {ECO:0000250}. |
| P17812 | CTPS1 | S324 | ochoa | CTP synthase 1 (EC 6.3.4.2) (CTP synthetase 1) (UTP--ammonia ligase 1) | This enzyme is involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen. This enzyme and its product, CTP, play a crucial role in the proliferation of activated lymphocytes and therefore in immunity. {ECO:0000269|PubMed:16179339, ECO:0000269|PubMed:24870241}. |
| P18085 | ARF4 | S147 | ochoa | ADP-ribosylation factor 4 | GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:25673879). {ECO:0000269|PubMed:25673879}. |
| P18206 | VCL | S820 | ochoa | Vinculin (Metavinculin) (MV) | Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. {ECO:0000269|PubMed:20484056}. |
| P20929 | NEB | S2182 | ochoa | Nebulin | This giant muscle protein may be involved in maintaining the structural integrity of sarcomeres and the membrane system associated with the myofibrils. Binds and stabilize F-actin. |
| P21757 | MSR1 | S27 | ochoa | Macrophage scavenger receptor types I and II (Macrophage acetylated LDL receptor I and II) (Scavenger receptor class A member 1) (CD antigen CD204) | Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL) (PubMed:2251254). Isoform III does not internalize acetylated LDL (PubMed:9548586). {ECO:0000269|PubMed:2251254, ECO:0000269|PubMed:9548586}. |
| P23458 | JAK1 | S963 | ochoa | Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1) | Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:16239216, PubMed:28111307, PubMed:32750333, PubMed:7615558, PubMed:8232552). Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529) as well as interleukin (IL)-10 receptor (PubMed:12133952). Kinase partner for the type I interferon receptor IFNAR2 (PubMed:16239216, PubMed:28111307, PubMed:32750333, PubMed:7615558, PubMed:8232552). In response to interferon-binding to IFNAR1-IFNAR2 heterodimer, phosphorylates and activates its binding partner IFNAR2, creating docking sites for STAT proteins (PubMed:7759950). Directly phosphorylates STAT proteins but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors (PubMed:16239216, PubMed:32750333, PubMed:8232552). {ECO:0000269|PubMed:11909529, ECO:0000269|PubMed:12133952, ECO:0000269|PubMed:16239216, ECO:0000269|PubMed:28111307, ECO:0000269|PubMed:32750333, ECO:0000269|PubMed:7615558, ECO:0000269|PubMed:7657660, ECO:0000269|PubMed:8232552}. |
| P23634 | ATP2B4 | S1149 | ochoa | Plasma membrane calcium-transporting ATPase 4 (PMCA4) (EC 7.2.2.10) (Matrix-remodeling-associated protein 1) (Plasma membrane calcium ATPase isoform 4) (Plasma membrane calcium pump isoform 4) | Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell (PubMed:8530416). By regulating sperm cell calcium homeostasis, may play a role in sperm motility (By similarity). {ECO:0000250|UniProtKB:Q6Q477, ECO:0000269|PubMed:8530416}. |
| P27448 | MARK3 | S724 | ochoa | MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (C-TAK1) (cTAK1) (Cdc25C-associated protein kinase 1) (ELKL motif kinase 2) (EMK-2) (Protein kinase STK10) (Ser/Thr protein kinase PAR-1) (Par-1a) (Serine/threonine-protein kinase p78) | Serine/threonine-protein kinase (PubMed:16822840, PubMed:16980613, PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Phosphorylates CDC25C on 'Ser-216' (PubMed:12941695). Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol (PubMed:16822840). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714). Phosphorylates PKP2 and KSR1 (PubMed:12941695). {ECO:0000269|PubMed:12941695, ECO:0000269|PubMed:16822840, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:23666762, ECO:0000269|PubMed:28087714}. |
| P28715 | ERCC5 | S1032 | ochoa | DNA excision repair protein ERCC-5 (EC 3.1.-.-) (DNA repair protein complementing XP-G cells) (XPG) (Xeroderma pigmentosum group G-complementing protein) | Single-stranded structure-specific DNA endonuclease involved in DNA excision repair (PubMed:32522879, PubMed:32821917, PubMed:7651464, PubMed:8078765, PubMed:8090225, PubMed:8206890). Makes the 3'incision in DNA nucleotide excision repair (NER) (PubMed:32522879, PubMed:32821917, PubMed:8078765, PubMed:8090225). Binds and bends DNA repair bubble substrate and breaks base stacking at the single-strand/double-strand DNA junction of the DNA bubble (PubMed:32522879). Plays a role in base excision repair (BER) by promoting the binding of DNA glycosylase NTHL1 to its substrate and increasing NTHL1 catalytic activity that removes oxidized pyrimidines from DNA (PubMed:9927729). Involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (PubMed:16246722). Functions during the initial step of TCR in cooperation with ERCC6/CSB to recognized stalled RNA polymerase II (PubMed:16246722). Also, stimulates ERCC6/CSB binding to the DNA repair bubble and ERCC6/CSB ATPase activity (PubMed:16246722). Required for DNA replication fork maintenance and preservation of genomic stability (PubMed:26833090, PubMed:32522879). Involved in homologous recombination repair (HRR) induced by DNA replication stress by recruiting RAD51, BRCA2, and PALB2 to the damaged DNA site (PubMed:26833090). In TFIIH stimulates the 5'-3' helicase activity of XPD/ERCC2 and the DNA translocase activity of XPB/ERCC3 (PubMed:31253769). During HRR, binds to the replication fork with high specificity and stabilizes it (PubMed:32522879). Also, acts upstream of HRR, to promote the release of BRCA1 from DNA (PubMed:26833090). {ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:26833090, ECO:0000269|PubMed:31253769, ECO:0000269|PubMed:32522879, ECO:0000269|PubMed:32821917, ECO:0000269|PubMed:7651464, ECO:0000269|PubMed:8078765, ECO:0000269|PubMed:8090225, ECO:0000269|PubMed:8206890, ECO:0000269|PubMed:9927729}. |
| P30305 | CDC25B | S209 | psp | M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B) | Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression (PubMed:1836978, PubMed:20360007). Directly dephosphorylates CDK1 and stimulates its kinase activity (PubMed:20360007). Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner (PubMed:17332740). The three isoforms seem to have a different level of activity (PubMed:1836978). {ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:1836978, ECO:0000269|PubMed:20360007}. |
| P33240 | CSTF2 | S103 | ochoa | Cleavage stimulation factor subunit 2 (CF-1 64 kDa subunit) (Cleavage stimulation factor 64 kDa subunit) (CSTF 64 kDa subunit) (CstF-64) | One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs. {ECO:0000269|PubMed:32816001, ECO:0000269|PubMed:9199325}. |
| P34931 | HSPA1L | S546 | ochoa | Heat shock 70 kDa protein 1-like (Heat shock 70 kDa protein 1L) (Heat shock 70 kDa protein 1-Hom) (HSP70-Hom) (Heat shock protein family A member 1L) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Positive regulator of PRKN translocation to damaged mitochondria (PubMed:24270810). {ECO:0000269|PubMed:24270810, ECO:0000303|PubMed:26865365}. |
| P35367 | HRH1 | S255 | ochoa | Histamine H1 receptor (H1-R) (H1R) (HH1R) | G-protein-coupled receptor for histamine, a biogenic amine that functions as an immune modulator and a neurotransmitter (PubMed:33828102, PubMed:8280179). Through the H1 receptor, histamine mediates the contraction of smooth muscles and increases capillary permeability due to contraction of terminal venules. Also mediates neurotransmission in the central nervous system and thereby regulates circadian rhythms, emotional and locomotor activities as well as cognitive functions (By similarity). {ECO:0000250|UniProtKB:P70174, ECO:0000269|PubMed:33828102, ECO:0000269|PubMed:8280179}. |
| P35579 | MYH9 | S541 | ochoa | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P35749 | MYH11 | S548 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
| P35749 | MYH11 | S1034 | ochoa | Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC) | Muscle contraction. |
| P42568 | MLLT3 | S301 | ochoa | Protein AF-9 (ALL1-fused gene from chromosome 9 protein) (Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein) (YEATS domain-containing protein 3) | Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948, PubMed:25417107, PubMed:27105114, PubMed:27545619). Specifically recognizes and binds acylated histone H3, with a preference for histone H3 that is crotonylated (PubMed:25417107, PubMed:27105114, PubMed:27545619, PubMed:30374167, PubMed:30385749). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25417107, PubMed:27105114, PubMed:27545619). Recognizes and binds histone H3 crotonylated at 'Lys-9' (H3K9cr), and with slightly lower affinity histone H3 crotonylated at 'Lys-18' (H3K18cr) (PubMed:27105114). Also recognizes and binds histone H3 acetylated and butyrylated at 'Lys-9' (H3K9ac and H3K9bu, respectively), but with lower affinity than crotonylated histone H3 (PubMed:25417107, PubMed:27105114, PubMed:30385749). In the SEC complex, MLLT3 is required to recruit the complex to crotonylated histones (PubMed:27105114, PubMed:27545619). Recruitment of the SEC complex to crotonylated histones promotes recruitment of DOT1L on active chromatin to deposit histone H3 'Lys-79' methylation (H3K79me) (PubMed:25417107). Plays a key role in hematopoietic stem cell (HSC) maintenance by preserving, rather than conferring, HSC stemness (PubMed:31776511). Acts by binding to the transcription start site of active genes in HSCs and sustaining level of H3K79me2, probably by recruiting DOT1L (PubMed:31776511). {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:25417107, ECO:0000269|PubMed:27105114, ECO:0000269|PubMed:27545619, ECO:0000269|PubMed:30374167, ECO:0000269|PubMed:30385749, ECO:0000269|PubMed:31776511}. |
| P46060 | RANGAP1 | S301 | ochoa | Ran GTPase-activating protein 1 (RanGAP1) | GTPase activator for RAN (PubMed:16428860, PubMed:8146159, PubMed:8896452). Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export (PubMed:27160050, PubMed:8896452). Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export (PubMed:27160050). {ECO:0000269|PubMed:16428860, ECO:0000269|PubMed:27160050, ECO:0000269|PubMed:8146159, ECO:0000269|PubMed:8896452}. |
| P46100 | ATRX | S850 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P47755 | CAPZA2 | S215 | ochoa | F-actin-capping protein subunit alpha-2 (CapZ alpha-2) | F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. |
| P48995 | TRPC1 | S206 | psp | Short transient receptor potential channel 1 (TrpC1) (Transient receptor protein 1) (TRP-1) | Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:11139478, PubMed:15016832, PubMed:39478185). Forms a heteromeric ion channel with TRPC4 or TRPC5 that has reduced calcium permeability compared to the homomeric TRPC4 or TRPC5 channel (PubMed:39478185). Also permeable to monovalent ions including sodium, lithium and cesium ions (PubMed:39478185). {ECO:0000269|PubMed:11139478, ECO:0000269|PubMed:15016832, ECO:0000269|PubMed:39478185}.; FUNCTION: [Isoform Short]: Forms a receptor-activated non-selective calcium permeant cation channel. Also activated by intracellular calcium store depletion. {ECO:0000269|PubMed:8663995}. |
| P49915 | GMPS | S282 | ochoa | GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) (GMP synthetase) (Glutamine amidotransferase) | Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate. {ECO:0000269|PubMed:8089153}. |
| P52630 | STAT2 | S187 | ochoa | Signal transducer and activator of transcription 2 (p113) | Signal transducer and activator of transcription that mediates signaling by type I interferons (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state (PubMed:23391734, PubMed:9020188). In addition, also has a negative feedback regulatory role in the type I interferon signaling by recruiting USP18 to the type I IFN receptor subunit IFNAR2 thereby mitigating the response to type I IFNs (PubMed:28165510). Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively (PubMed:23391734, PubMed:26122121, PubMed:9020188). {ECO:0000269|PubMed:23391734, ECO:0000269|PubMed:26122121, ECO:0000269|PubMed:28165510, ECO:0000269|PubMed:31836668, ECO:0000269|PubMed:32092142, ECO:0000269|PubMed:9020188}. |
| P53618 | COPB1 | S371 | ochoa | Coatomer subunit beta (Beta-coat protein) (Beta-COP) | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Plays a functional role in facilitating the transport of kappa-type opioid receptor mRNAs into axons and enhances translation of these proteins. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte surface triglyceride lipase (PNPLA2) with the lipid droplet to mediate lipolysis (By similarity). Involved in the Golgi disassembly and reassembly processes during cell cycle. Involved in autophagy by playing a role in early endosome function. Plays a role in organellar compartmentalization of secretory compartments including endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC), Golgi, trans-Golgi network (TGN) and recycling endosomes, and in biosynthetic transport of CAV1. Promotes degradation of Nef cellular targets CD4 and MHC class I antigens by facilitating their trafficking to degradative compartments. {ECO:0000250, ECO:0000269|PubMed:18385291, ECO:0000269|PubMed:18725938, ECO:0000269|PubMed:19364919, ECO:0000269|PubMed:20056612}. |
| P54132 | BLM | S349 | ochoa | RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) | ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}. |
| P55011 | SLC12A2 | S242 | ochoa|psp | Solute carrier family 12 member 2 (Basolateral Na-K-Cl symporter) (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2) (BSC2) (Na-K-2Cl cotransporter 1) (hNKCC1) | Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:33597714, PubMed:35585053, PubMed:36239040, PubMed:36306358, PubMed:7629105). Plays a vital role in the regulation of ionic balance and cell volume (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:7629105). {ECO:0000269|PubMed:16669787, ECO:0000269|PubMed:32081947, ECO:0000269|PubMed:32294086, ECO:0000269|PubMed:33597714, ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36239040, ECO:0000269|PubMed:36306358, ECO:0000269|PubMed:7629105}. |
| P61204 | ARF3 | S147 | ochoa | ADP-ribosylation factor 3 | GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. |
| P62826 | RAN | S135 | ochoa|psp | GTP-binding nuclear protein Ran (EC 3.6.5.-) (Androgen receptor-associated protein 24) (GTPase Ran) (Ras-like protein TC4) (Ras-related nuclear protein) | GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs (PubMed:10400640, PubMed:17209048, PubMed:26272610, PubMed:27306458, PubMed:8276887, PubMed:8636225, PubMed:8692944, PubMed:8896452, PubMed:9351834, PubMed:9428644, PubMed:9822603). Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis (PubMed:11336674, PubMed:26272610, PubMed:29040603, PubMed:7819259, PubMed:8636225, PubMed:8692944, PubMed:8896452, PubMed:9351834, PubMed:9428644, PubMed:9822603). Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport (PubMed:8896452, PubMed:9351834, PubMed:9428644). Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (PubMed:20485264). RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation (PubMed:10408446, PubMed:29040603). Required for normal progress through mitosis (PubMed:12194828, PubMed:29040603, PubMed:8421051). The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (PubMed:18591255). Acts as a negative regulator of the kinase activity of VRK1 and VRK2 (PubMed:18617507). Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases (PubMed:10400640). {ECO:0000269|PubMed:10400640, ECO:0000269|PubMed:10408446, ECO:0000269|PubMed:11336674, ECO:0000269|PubMed:12194828, ECO:0000269|PubMed:17209048, ECO:0000269|PubMed:18591255, ECO:0000269|PubMed:18617507, ECO:0000269|PubMed:20485264, ECO:0000269|PubMed:26272610, ECO:0000269|PubMed:27306458, ECO:0000269|PubMed:29040603, ECO:0000269|PubMed:7819259, ECO:0000269|PubMed:8276887, ECO:0000269|PubMed:8421051, ECO:0000269|PubMed:8636225, ECO:0000269|PubMed:8692944, ECO:0000269|PubMed:8896452, ECO:0000269|PubMed:9351834, ECO:0000269|PubMed:9428644, ECO:0000269|PubMed:9822603, ECO:0000305|PubMed:26272610}. |
| P68104 | EEF1A1 | S224 | ochoa | Elongation factor 1-alpha 1 (EF-1-alpha-1) (EC 3.6.5.-) (Elongation factor Tu) (EF-Tu) (Eukaryotic elongation factor 1 A-1) (eEF1A-1) (Leukocyte receptor cluster member 7) | Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623, PubMed:36638793). Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623, PubMed:36638793). The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623). Also plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1 (PubMed:17177976). Also plays a role in cytoskeleton organization by promoting actin bundling (By similarity). {ECO:0000250|UniProtKB:P68105, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:26593721, ECO:0000269|PubMed:26651998, ECO:0000269|PubMed:36123449, ECO:0000269|PubMed:36264623, ECO:0000269|PubMed:36638793}.; FUNCTION: (Microbial infection) Required for the translation of viral proteins and viral replication during human coronavirus SARS-CoV-2 infection. {ECO:0000269|PubMed:33495306}. |
| P78344 | EIF4G2 | S602 | ochoa | Eukaryotic translation initiation factor 4 gamma 2 (eIF-4-gamma 2) (eIF-4G 2) (eIF4G 2) (Death-associated protein 5) (DAP-5) (p97) | Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases. {ECO:0000269|PubMed:11511540, ECO:0000269|PubMed:11943866, ECO:0000269|PubMed:9032289, ECO:0000269|PubMed:9049310}. |
| P78527 | PRKDC | S314 | ochoa | DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) | Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250|UniProtKB:P97313, ECO:0000269|PubMed:10026262, ECO:0000269|PubMed:10467406, ECO:0000269|PubMed:11889123, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12509254, ECO:0000269|PubMed:12649176, ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:14612514, ECO:0000269|PubMed:14627815, ECO:0000269|PubMed:14704337, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:15262962, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:1597196, ECO:0000269|PubMed:16046194, ECO:0000269|PubMed:16397295, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:2247066, ECO:0000269|PubMed:2507541, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30247612, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33854234, ECO:0000269|PubMed:34352203, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:8407951, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9362500, ECO:0000269|PubMed:9363941, ECO:0000269|PubMed:9679063}. |
| P84077 | ARF1 | S147 | ochoa | ADP-ribosylation factor 1 (EC 3.6.5.2) | Small GTPase involved in protein trafficking between different compartments (PubMed:8253837). Modulates vesicle budding and uncoating within the Golgi complex (PubMed:8253837). In its GTP-bound form, triggers the recruitment of coatomer proteins to the Golgi membrane (PubMed:8253837). The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles (PubMed:8253837). The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasticity of excitatory synapses and spine shrinkage during long-term depression (LTD) (By similarity). Plays a key role in the regulation of intestinal stem cells and gut microbiota, and is essential for maintaining intestinal homeostasis (By similarity). Also plays a critical role in mast cell expansion but not in mast cell maturation by facilitating optimal mTORC1 activation (By similarity). {ECO:0000250|UniProtKB:P84079, ECO:0000269|PubMed:8253837}.; FUNCTION: (Microbial infection) Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. {ECO:0000305}. |
| Q00341 | HDLBP | S317 | ochoa | Vigilin (High density lipoprotein-binding protein) (HDL-binding protein) | Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol. |
| Q01082 | SPTBN1 | S1057 | ochoa | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
| Q01196 | RUNX1 | S193 | ochoa | Runt-related transcription factor 1 (Acute myeloid leukemia 1 protein) (Core-binding factor subunit alpha-2) (CBF-alpha-2) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEA2-alpha B) (PEBP2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit) | Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (Probable). Essential for the development of normal hematopoiesis (PubMed:17431401). Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter (PubMed:10207087, PubMed:14970218). Inhibits KAT6B-dependent transcriptional activation (By similarity). Involved in lineage commitment of immature T cell precursors. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity). Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3. Activates the expression of IL2 and IFNG and down-regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells (PubMed:17377532). Positively regulates the expression of RORC in T-helper 17 cells (By similarity). {ECO:0000250|UniProtKB:Q03347, ECO:0000269|PubMed:10207087, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:14970218, ECO:0000269|PubMed:17377532, ECO:0000269|PubMed:17431401, ECO:0000305}.; FUNCTION: Isoform AML-1G shows higher binding activities for target genes and binds TCR-beta-E2 and RAG-1 target site with threefold higher affinity than other isoforms. It is less effective in the context of neutrophil terminal differentiation. {ECO:0000250|UniProtKB:Q03347}.; FUNCTION: Isoform AML-1L interferes with the transactivation activity of RUNX1. {ECO:0000269|PubMed:9199349}. |
| Q01814 | ATP2B2 | S1150 | ochoa | Plasma membrane calcium-transporting ATPase 2 (PMCA2) (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 2) (Plasma membrane calcium pump isoform 2) | ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels in specialized cells of cerebellar circuit and vestibular and cochlear systems (PubMed:15829536, PubMed:17234811). Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment (PubMed:15829536, PubMed:17234811). Has fast activation and Ca(2+) clearance rate suited to control fast neuronal Ca(2+) dynamics. At parallel fiber to Purkinje neuron synapse, mediates presynaptic Ca(2+) efflux in response to climbing fiber-induced Ca(2+) rise. Provides for fast return of Ca(2+) concentrations back to their resting levels, ultimately contributing to long-term depression induction and motor learning (By similarity). Plays an essential role in hearing and balance (PubMed:15829536, PubMed:17234811). In cochlear hair cells, shuttles Ca(2+) ions from stereocilia to the endolymph and dissipates Ca(2+) transients generated by the opening of the mechanoelectrical transduction channels. Regulates Ca(2+) levels in the vestibular system, where it contributes to the formation of otoconia (PubMed:15829536, PubMed:17234811). In non-excitable cells, regulates Ca(2+) signaling through spatial control of Ca(2+) ions extrusion and dissipation of Ca(2+) transients generated by store-operated channels (PubMed:25690014). In lactating mammary gland, allows for the high content of Ca(2+) ions in the milk (By similarity). {ECO:0000250|UniProtKB:Q9R0K7, ECO:0000269|PubMed:15829536, ECO:0000269|PubMed:17234811, ECO:0000269|PubMed:25690014}. |
| Q02539 | H1-1 | S105 | ochoa | Histone H1.1 (Histone H1a) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| Q03188 | CENPC | S96 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
| Q06190 | PPP2R3A | S562 | ochoa | Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha (PP2A subunit B isoform PR72/PR130) (PP2A subunit B isoform R3 isoform) (PP2A subunit B isoforms B''-PR72/PR130) (PP2A subunit B isoforms B72/B130) (Serine/threonine-protein phosphatase 2A 72/130 kDa regulatory subunit B) | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. |
| Q07864 | POLE | S1184 | ochoa | DNA polymerase epsilon catalytic subunit A (EC 2.7.7.7) (3'-5' exodeoxyribonuclease) (EC 3.1.11.-) (DNA polymerase II subunit A) | Catalytic component of the DNA polymerase epsilon complex (PubMed:10801849). Participates in chromosomal DNA replication (By similarity). Required during synthesis of the leading DNA strands at the replication fork, binds at/or near replication origins and moves along DNA with the replication fork (By similarity). Has 3'-5' proofreading exonuclease activity that corrects errors arising during DNA replication (By similarity). Involved in DNA synthesis during DNA repair (PubMed:20227374, PubMed:27573199). Along with DNA polymerase POLD1 and DNA polymerase POLK, has a role in excision repair (NER) synthesis following UV irradiation (PubMed:20227374). {ECO:0000250|UniProtKB:P21951, ECO:0000269|PubMed:10801849, ECO:0000269|PubMed:20227374, ECO:0000269|PubMed:27573199}. |
| Q09666 | AHNAK | S1571 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S4953 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q13153 | PAK1 | S249 | ochoa | Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (Alpha-PAK) (p21-activated kinase 1) (PAK-1) (p65-PAK) | Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes (PubMed:10551809, PubMed:11896197, PubMed:12876277, PubMed:14585966, PubMed:15611088, PubMed:17726028, PubMed:17989089, PubMed:30290153, PubMed:17420447). Can directly phosphorylate BAD and protects cells against apoptosis (By similarity). Activated by interaction with CDC42 and RAC1 (PubMed:8805275, PubMed:9528787). Functions as a GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway (PubMed:8805275, PubMed:9528787). Phosphorylates and activates MAP2K1, and thereby mediates activation of downstream MAP kinases (By similarity). Involved in the reorganization of the actin cytoskeleton, actin stress fibers and of focal adhesion complexes (PubMed:9032240, PubMed:9395435). Phosphorylates the tubulin chaperone TBCB and thereby plays a role in the regulation of microtubule biogenesis and organization of the tubulin cytoskeleton (PubMed:15831477). Plays a role in the regulation of insulin secretion in response to elevated glucose levels (PubMed:22669945). Part of a ternary complex that contains PAK1, DVL1 and MUSK that is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By similarity). Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2 (PubMed:12624090). Phosphorylates MYL9/MLC2 (By similarity). Phosphorylates RAF1 at 'Ser-338' and 'Ser-339' resulting in: activation of RAF1, stimulation of RAF1 translocation to mitochondria, phosphorylation of BAD by RAF1, and RAF1 binding to BCL2 (PubMed:11733498). Phosphorylates SNAI1 at 'Ser-246' promoting its transcriptional repressor activity by increasing its accumulation in the nucleus (PubMed:15833848). In podocytes, promotes NR3C2 nuclear localization (By similarity). Required for atypical chemokine receptor ACKR2-induced phosphorylation of LIMK1 and cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:23633677). In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3, maybe through CFL1 phosphorylation and inactivation (By similarity). Plays a role in RUFY3-mediated facilitating gastric cancer cells migration and invasion (PubMed:25766321). In response to DNA damage, phosphorylates MORC2 which activates its ATPase activity and facilitates chromatin remodeling (PubMed:23260667). In neurons, plays a crucial role in regulating GABA(A) receptor synaptic stability and hence GABAergic inhibitory synaptic transmission through its role in F-actin stabilization (By similarity). In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity). Along with GIT1, positively regulates microtubule nucleation during interphase (PubMed:27012601). Phosphorylates FXR1, promoting its localization to stress granules and activity (PubMed:20417602). Phosphorylates ILK on 'Thr-173' and 'Ser-246', promoting nuclear export of ILK (PubMed:17420447). {ECO:0000250|UniProtKB:O88643, ECO:0000250|UniProtKB:P35465, ECO:0000269|PubMed:10551809, ECO:0000269|PubMed:11733498, ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:12624090, ECO:0000269|PubMed:12876277, ECO:0000269|PubMed:14585966, ECO:0000269|PubMed:15611088, ECO:0000269|PubMed:15831477, ECO:0000269|PubMed:15833848, ECO:0000269|PubMed:17420447, ECO:0000269|PubMed:17726028, ECO:0000269|PubMed:17989089, ECO:0000269|PubMed:20417602, ECO:0000269|PubMed:22669945, ECO:0000269|PubMed:23260667, ECO:0000269|PubMed:23633677, ECO:0000269|PubMed:25766321, ECO:0000269|PubMed:27012601, ECO:0000269|PubMed:30290153, ECO:0000269|PubMed:8805275, ECO:0000269|PubMed:9032240, ECO:0000269|PubMed:9395435, ECO:0000269|PubMed:9528787}. |
| Q13315 | ATM | S1403 | psp | Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T mutated) | Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor (PubMed:10550055, PubMed:10839545, PubMed:10910365, PubMed:12556884, PubMed:14871926, PubMed:15064416, PubMed:15448695, PubMed:15456891, PubMed:15790808, PubMed:15916964, PubMed:17923702, PubMed:21757780, PubMed:24534091, PubMed:35076389, PubMed:9733514). Recognizes the substrate consensus sequence [ST]-Q (PubMed:10550055, PubMed:10839545, PubMed:10910365, PubMed:12556884, PubMed:14871926, PubMed:15448695, PubMed:15456891, PubMed:15916964, PubMed:17923702, PubMed:24534091, PubMed:9733514). Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism (By similarity). Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FBXW7, FANCD2, NFKBIA, BRCA1, CREBBP/CBP, RBBP8/CTIP, FBXO46, MRE11, nibrin (NBN), RAD50, RAD17, PELI1, TERF1, UFL1, RAD9, UBQLN4 and DCLRE1C (PubMed:10550055, PubMed:10766245, PubMed:10802669, PubMed:10839545, PubMed:10910365, PubMed:10973490, PubMed:11375976, PubMed:12086603, PubMed:15456891, PubMed:19965871, PubMed:21757780, PubMed:24534091, PubMed:26240375, PubMed:26774286, PubMed:30171069, PubMed:30612738, PubMed:30886146, PubMed:30952868, PubMed:38128537, PubMed:9733515, PubMed:9843217). May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation (PubMed:19965871). Phosphorylates ATF2 which stimulates its function in DNA damage response (PubMed:15916964). Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks (PubMed:29203878). Phosphorylates TTC5/STRAP at 'Ser-203' in the cytoplasm in response to DNA damage, which promotes TTC5/STRAP nuclear localization (PubMed:15448695). Also involved in pexophagy by mediating phosphorylation of PEX5: translocated to peroxisomes in response to reactive oxygen species (ROS), and catalyzes phosphorylation of PEX5, promoting PEX5 ubiquitination and induction of pexophagy (PubMed:26344566). {ECO:0000250|UniProtKB:Q62388, ECO:0000269|PubMed:10550055, ECO:0000269|PubMed:10766245, ECO:0000269|PubMed:10802669, ECO:0000269|PubMed:10839545, ECO:0000269|PubMed:10910365, ECO:0000269|PubMed:10973490, ECO:0000269|PubMed:11375976, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12556884, ECO:0000269|PubMed:14871926, ECO:0000269|PubMed:15448695, ECO:0000269|PubMed:15456891, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:16086026, ECO:0000269|PubMed:16858402, ECO:0000269|PubMed:17923702, ECO:0000269|PubMed:19431188, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:21757780, ECO:0000269|PubMed:24534091, ECO:0000269|PubMed:26240375, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:26774286, ECO:0000269|PubMed:29203878, ECO:0000269|PubMed:30171069, ECO:0000269|PubMed:30612738, ECO:0000269|PubMed:30886146, ECO:0000269|PubMed:30952868, ECO:0000269|PubMed:35076389, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9733514, ECO:0000269|PubMed:9733515, ECO:0000269|PubMed:9843217}. |
| Q13352 | ITGB3BP | S71 | ochoa | Centromere protein R (CENP-R) (Beta-3-endonexin) (Integrin beta-3-binding protein) (Nuclear receptor-interacting factor 3) | Transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. May also act as an inhibitor of cyclin A-associated kinase. Also acts a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. {ECO:0000269|PubMed:11713274, ECO:0000269|PubMed:12244126, ECO:0000269|PubMed:15082778, ECO:0000269|PubMed:15254226, ECO:0000269|PubMed:16622420}. |
| Q13621 | SLC12A1 | S130 | psp | Solute carrier family 12 member 1 (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1) (BSC1) (Kidney-specific Na-K-Cl symporter) (Na-K-2Cl cotransporter 2) (NKCC2) | Renal sodium, potassium and chloride ion cotransporter that mediates the transepithelial NaCl reabsorption in the thick ascending limb and plays an essential role in the urinary concentration and volume regulation (PubMed:21321328). Electrically silent transporter system (By similarity). {ECO:0000250|UniProtKB:P55014, ECO:0000250|UniProtKB:P55016, ECO:0000269|PubMed:21321328}. |
| Q13873 | BMPR2 | S680 | ochoa | Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Can also mediate signaling through the activation of the p38MAPK cascade (PubMed:12045205). Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6. Promotes signaling also by binding to activin A/INHBA (PubMed:24018044). {ECO:0000250|UniProtKB:O35607, ECO:0000269|PubMed:12045205, ECO:0000269|PubMed:24018044}. |
| Q14141 | SEPTIN6 | S319 | ochoa | Septin-6 | Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). {ECO:0000269|PubMed:17229681, ECO:0000269|PubMed:17803907, ECO:0000305|PubMed:25588830}. |
| Q14432 | PDE3A | S428 | ochoa|psp | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A) (cGMP-inhibited cAMP phosphodiesterase) (cGI-PDE) | Cyclic nucleotide phosphodiesterase with specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:1315035, PubMed:25961942, PubMed:8155697, PubMed:8695850). Also has activity toward cUMP (PubMed:27975297). Independently of its catalytic activity it is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling (PubMed:31420216, PubMed:34707099). {ECO:0000269|PubMed:1315035, ECO:0000269|PubMed:25961942, ECO:0000269|PubMed:27975297, ECO:0000269|PubMed:31420216, ECO:0000269|PubMed:34707099, ECO:0000269|PubMed:8155697, ECO:0000269|PubMed:8695850}. |
| Q14435 | GALNT3 | S134 | ochoa | Polypeptide N-acetylgalactosaminyltransferase 3 (EC 2.4.1.41) (Polypeptide GalNAc transferase 3) (GalNAc-T3) (pp-GaNTase 3) (Protein-UDP acetylgalactosaminyltransferase 3) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3) | Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor (PubMed:16638743, PubMed:31932717, PubMed:8663203, PubMed:9295285). Has activity toward HIV envelope glycoprotein gp120, EA2, MUC2, MUC1A and MUC5AC (PubMed:8663203, PubMed:9295285). Probably glycosylates fibronectin in vivo (PubMed:9295285). Glycosylates FGF23 (PubMed:16638743, PubMed:31932717). {ECO:0000269|PubMed:16638743, ECO:0000269|PubMed:31932717, ECO:0000269|PubMed:8663203, ECO:0000269|PubMed:9295285}. |
| Q15022 | SUZ12 | S539 | ochoa|psp | Polycomb protein SUZ12 (Chromatin precipitated E2F target 9 protein) (ChET 9 protein) (Joined to JAZF1 protein) (Suppressor of zeste 12 protein homolog) | Polycomb group (PcG) protein. Component of the PRC2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:15231737, PubMed:15385962, PubMed:16618801, PubMed:17344414, PubMed:18285464, PubMed:28229514, PubMed:29499137, PubMed:31959557). The PRC2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (PubMed:12351676, PubMed:12435631, PubMed:15099518, PubMed:15225548, PubMed:15385962, PubMed:15684044, PubMed:16431907, PubMed:18086877, PubMed:18285464). Genes repressed by the PRC2 complex include HOXC8, HOXA9, MYT1 and CDKN2A (PubMed:15231737, PubMed:16618801, PubMed:17200670, PubMed:31959557). {ECO:0000269|PubMed:12351676, ECO:0000269|PubMed:12435631, ECO:0000269|PubMed:15099518, ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15385962, ECO:0000269|PubMed:15684044, ECO:0000269|PubMed:16431907, ECO:0000269|PubMed:16618801, ECO:0000269|PubMed:17200670, ECO:0000269|PubMed:17344414, ECO:0000269|PubMed:18086877, ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:28229514, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}. |
| Q15149 | PLEC | S701 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q15185 | PTGES3 | S72 | ochoa | Prostaglandin E synthase 3 (EC 5.3.99.3) (Cytosolic prostaglandin E2 synthase) (cPGES) (Hsp90 co-chaperone) (Progesterone receptor complex p23) (Telomerase-binding protein p23) | Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448). {ECO:0000269|PubMed:10922363, ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:12077419, ECO:0000269|PubMed:24711448}. |
| Q16665 | HIF1A | S761 | psp | Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8) | Functions as a master transcriptional regulator of the adaptive response to hypoxia (PubMed:11292861, PubMed:11566883, PubMed:15465032, PubMed:16973622, PubMed:17610843, PubMed:18658046, PubMed:20624928, PubMed:22009797, PubMed:30125331, PubMed:9887100). Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia (PubMed:11292861, PubMed:11566883, PubMed:15465032, PubMed:16973622, PubMed:17610843, PubMed:20624928, PubMed:22009797, PubMed:30125331, PubMed:9887100). Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease (PubMed:22009797). Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300 (PubMed:16543236, PubMed:9887100). Activity is enhanced by interaction with NCOA1 and/or NCOA2 (PubMed:10594042). Interaction with redox regulatory protein APEX1 seems to activate CTAD and potentiates activation by NCOA1 and CREBBP (PubMed:10202154, PubMed:10594042). Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia (PubMed:19528298). {ECO:0000250|UniProtKB:Q61221, ECO:0000269|PubMed:10202154, ECO:0000269|PubMed:10594042, ECO:0000269|PubMed:11292861, ECO:0000269|PubMed:11566883, ECO:0000269|PubMed:15465032, ECO:0000269|PubMed:16543236, ECO:0000269|PubMed:16973622, ECO:0000269|PubMed:17610843, ECO:0000269|PubMed:18658046, ECO:0000269|PubMed:19528298, ECO:0000269|PubMed:20624928, ECO:0000269|PubMed:22009797, ECO:0000269|PubMed:30125331, ECO:0000269|PubMed:9887100}.; FUNCTION: (Microbial infection) Upon infection by human coronavirus SARS-CoV-2, is required for induction of glycolysis in monocytes and the consequent pro-inflammatory state (PubMed:32697943). In monocytes, induces expression of ACE2 and cytokines such as IL1B, TNF, IL6, and interferons (PubMed:32697943). Promotes human coronavirus SARS-CoV-2 replication and monocyte inflammatory response (PubMed:32697943). {ECO:0000269|PubMed:32697943}. |
| Q3MHD2 | LSM12 | S157 | ochoa | Protein LSM12 | Nicotinic acid adenine dinucleotide phosphate (NAADP) binding protein (PubMed:34362892). Confers NAADP sensitivity to the two pore channel complex (TPCs) by acting as TPC accessory protein necessary for NAADP-evoked Ca(2+) release (PubMed:34362892). {ECO:0000269|PubMed:34362892}. |
| Q4KWH8 | PLCH1 | S1028 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-eta-1) (Phospholipase C-eta-1) (PLC-eta-1) (Phospholipase C-like protein 3) (PLC-L3) | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by calcium-activated phosphatidylinositol-specific phospholipase C enzymes. {ECO:0000269|PubMed:15702972}. |
| Q5CZC0 | FSIP2 | S3175 | ochoa | Fibrous sheath-interacting protein 2 | Plays a role in spermatogenesis. {ECO:0000305|PubMed:30137358}. |
| Q5JSH3 | WDR44 | S161 | ochoa | WD repeat-containing protein 44 (Rab11-binding protein) (Rab11BP) (Rabphilin-11) | Downstream effector for Rab11 which regulates Rab11 intracellular membrane trafficking functions such as endocytic recycling, intracellular ciliogenesis and protein export (PubMed:31204173, PubMed:32344433). ATK1-mediated phosphorylation of WDR44 induces binding to Rab11 which activates endocytic recycling of transferrin receptor back to the plasma membrane (PubMed:31204173). When bound to Rab11, prevents the formation of the ciliogenic Rab11-Rabin8/RAB3IP-RAB11FIP3 complex, therefore inhibiting preciliary trafficking and ciliogenesis (PubMed:31204173). Participates in neo-synthesized protein export by connecting the endoplasmic reticulum (ER) with the endosomal tubule via direct interactions with the integral ER proteins VAPA or VAPB and the endosomal protein GRAFs (GRAF1/ARHGAP26 or GRAF2/ARHGAP10), which facilitates the transfer of proteins such as E-cadherin, MPP14 and CFTR into a Rab8-Rab10-Rab11-dependent export route (PubMed:32344433). {ECO:0000269|PubMed:31204173, ECO:0000269|PubMed:32344433}. |
| Q5VT06 | CEP350 | S2362 | ochoa | Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) | Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CPAP (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}. |
| Q5VTE0 | EEF1A1P5 | S224 | ochoa | Putative elongation factor 1-alpha-like 3 (EF-1-alpha-like 3) (Eukaryotic elongation factor 1 A-like 3) (eEF1A-like 3) (Eukaryotic translation elongation factor 1 alpha-1 pseudogene 5) | This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. {ECO:0000250}. |
| Q6RI45 | BRWD3 | S886 | ochoa | Bromodomain and WD repeat-containing protein 3 | Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000269|PubMed:21834987}. |
| Q6VY07 | PACS1 | S451 | ochoa | Phosphofurin acidic cluster sorting protein 1 (PACS-1) | Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN. Required for normal ER Ca2+ handling in lymphocytes. Together with WDR37, it plays an essential role in lymphocyte development, quiescence and survival. Required for stabilizing peripheral lymphocyte populations (By similarity). {ECO:0000250|UniProtKB:Q8K212, ECO:0000269|PubMed:11331585, ECO:0000269|PubMed:15692563}. |
| Q6ZQN7 | SLCO4C1 | S79 | ochoa | Solute carrier organic anion transporter family member 4C1 (SLCO4C1) (OATP-H) (Organic anion transporter M1) (OATP-M1) (Organic anion transporting polypeptide 4C1) (OATP4C1) (Solute carrier family 21 member 20) | Mediates the transport of organic anions such as steroids (estrone 3-sulfate, chenodeoxycholate, glycocholate) and thyroid hormones (3,3',5-triiodo-L-thyronine (T3), L-thyroxine (T4)), in the kidney (PubMed:14993604, PubMed:19129463, PubMed:20610891). Capable of transporting cAMP and pharmacological substances such as digoxin, ouabain and methotrexate (PubMed:14993604). Transport is independent of sodium, chloride ion, and ATP (PubMed:14993604). Transport activity is stimulated by an acidic extracellular environment due to increased substrate affinity to the transporter (PubMed:19129463). The driving force for this transport activity is currently not known (By similarity). The role of hydrogencarbonate (HCO3(-), bicarbonate) as the probable counteranion that exchanges for organic anions is still not well defined (PubMed:19129463). Functions as an uptake transporter at the apical membrane, suggesting a role in renal reabsorption (By similarity). Involved in the renal secretion of the uremic toxin ADMA (N(omega),N(omega)-dimethyl-L-arginine or asymmetrical dimethylarginine), which is associated to cardiovascular events and mortality, and the structurally related amino acids L-arginine and L-homoarginine (a cardioprotective biomarker) (PubMed:30865704). Can act bidirectionally, suggesting a dual protective role of this transport protein; exporting L-homoarginine after being synthesized in proximal tubule cells, and mediating uptake of ADMA from the blood into proximal tubule cells where it is degraded by the enzyme dimethylarginine dimethylaminohydrolase 1 (DDAH1) (PubMed:30865704, PubMed:32642843). May be involved in sperm maturation by enabling directed movement of organic anions and compounds within or between cells (By similarity). This ion-transporting process is important to maintain the strict epididymal homeostasis necessary for sperm maturation (By similarity). May have a role in secretory functions since seminal vesicle epithelial cells are assumed to secrete proteins involved in decapacitation by modifying surface proteins to facilitate the acquisition of the ability to fertilize the egg (By similarity). {ECO:0000250|UniProtKB:Q71MB6, ECO:0000250|UniProtKB:Q8BGD4, ECO:0000269|PubMed:14993604, ECO:0000269|PubMed:19129463, ECO:0000269|PubMed:20610891, ECO:0000269|PubMed:30865704, ECO:0000269|PubMed:32642843}. |
| Q6ZV29 | PNPLA7 | S469 | ochoa | Patatin-like phospholipase domain-containing protein 7 (EC 3.1.1.-) (EC 3.1.1.5) | Lysophospholipase which preferentially deacylates unsaturated lysophosphatidylcholine (C18:1), generating glycerophosphocholine. Also can deacylate, to a lesser extent, lysophosphatidylethanolamine (C18:1), lysophosphatidyl-L-serine (C18:1) and lysophosphatidic acid (C16:0). {ECO:0000250|UniProtKB:A2AJ88}. |
| Q709C8 | VPS13C | S737 | ochoa | Intermembrane lipid transfer protein VPS13C (Vacuolar protein sorting-associated protein 13C) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Necessary for proper mitochondrial function and maintenance of mitochondrial transmembrane potential (PubMed:26942284). Involved in the regulation of PINK1/PRKN-mediated mitophagy in response to mitochondrial depolarization (PubMed:26942284). {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:26942284}. |
| Q70Z53 | FRA10AC1 | S251 | ochoa | Protein FRA10AC1 | May be involved in pre-mRNA splicing. {ECO:0000269|PubMed:34694367}. |
| Q70Z53 | FRA10AC1 | S252 | ochoa | Protein FRA10AC1 | May be involved in pre-mRNA splicing. {ECO:0000269|PubMed:34694367}. |
| Q7KZI7 | MARK2 | S759 | ochoa | Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:12429843, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15158914, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:15365179, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:18626018, ECO:0000269|PubMed:20194617, ECO:0000269|PubMed:23666762}. |
| Q7L576 | CYFIP1 | S582 | ochoa | Cytoplasmic FMR1-interacting protein 1 (Specifically Rac1-associated protein 1) (Sra-1) (p140sra-1) | Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). May act as an invasion suppressor in cancers. {ECO:0000250|UniProtKB:Q7TMB8, ECO:0000269|PubMed:16260607, ECO:0000269|PubMed:19524508, ECO:0000269|PubMed:21107423, ECO:0000269|PubMed:9417078}. |
| Q7Z3E2 | CCDC186 | S157 | ochoa | Coiled-coil domain-containing protein 186 (CTCL tumor antigen HD-CL-01/L14-2) | None |
| Q7Z3T8 | ZFYVE16 | S330 | ochoa | Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome-associated FYVE domain protein) | May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes. {ECO:0000269|PubMed:11546807, ECO:0000269|PubMed:14613930}. |
| Q7Z406 | MYH14 | S567 | ochoa | Myosin-14 (Myosin heavy chain 14) (Myosin heavy chain, non-muscle IIc) (Non-muscle myosin heavy chain IIc) (NMHC II-C) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. {ECO:0000250}. |
| Q7Z7A4 | PXK | S470 | ochoa | PX domain-containing protein kinase-like protein (Modulator of Na,K-ATPase) (MONaKA) | Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity. {ECO:0000250|UniProtKB:Q8BX57, ECO:0000303|PubMed:16142408}. |
| Q86WG5 | SBF2 | S1104 | ochoa | Myotubularin-related protein 13 (Inactive phosphatidylinositol 3-phosphatase 13) (SET-binding factor 2) | Guanine nucleotide exchange factor (GEF) which activates RAB21 and possibly RAB28 (PubMed:20937701, PubMed:25648148). Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (PubMed:20937701, PubMed:25648148). In response to starvation-induced autophagy, activates RAB21 which in turn binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (PubMed:25648148). Acts as an adapter for the phosphatase MTMR2 (By similarity). Increases MTMR2 catalytic activity towards phosphatidylinositol 3,5-bisphosphate and to a lesser extent towards phosphatidylinositol 3-phosphate (By similarity). {ECO:0000250|UniProtKB:E9PXF8, ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:25648148}. |
| Q8IVH8 | MAP4K3 | S398 | ochoa | Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (Germinal center kinase-related protein kinase) (GLK) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) | Serine/threonine kinase that plays a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway (PubMed:9275185). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:9275185}. |
| Q8IY57 | YAF2 | S111 | ochoa | YY1-associated factor 2 | Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1 complex, a repressive complex that methylates 'Lys-9' of histone H3, suggesting that it is involved in chromatin-remodeling. {ECO:0000269|PubMed:11593398, ECO:0000269|PubMed:12706874, ECO:0000269|PubMed:9016636}. |
| Q8IYL3 | C1orf174 | S148 | ochoa | UPF0688 protein C1orf174 | None |
| Q8N0X7 | SPART | S102 | ochoa | Spartin (Spastic paraplegia 20 protein) (Trans-activated by hepatitis C virus core protein 1) | Lipophagy receptor that plays an important role in lipid droplet (LD) turnover in motor neurons (PubMed:37443287). Localizes to LDs and interacts with components of the autophagy machinery, such as MAP1LC3A/C proteins to deliver LDs to autophagosomes for degradation via lipophagy (PubMed:37443287). Lipid transfer protein required for lipid droplet degradation, including by lipophagy (PubMed:38190532). Can bind and transfer all lipid species found in lipid droplets, from phospholipids to triglycerides and sterol esters but the direction of lipid transfer by spartin and its cargos are unknown (PubMed:38190532). May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis (PubMed:20719964). {ECO:0000269|PubMed:20719964, ECO:0000269|PubMed:37443287, ECO:0000269|PubMed:38190532}. |
| Q8NCD3 | HJURP | S496 | ochoa | Holliday junction recognition protein (14-3-3-associated AKT substrate) (Fetal liver-expressing gene 1 protein) (Up-regulated in lung cancer 9) | Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions. {ECO:0000269|PubMed:19410544, ECO:0000269|PubMed:19410545}. |
| Q8NE01 | CNNM3 | S467 | ochoa | Metal transporter CNNM3 (Ancient conserved domain-containing protein 3) (Cyclin-M3) | Probable metal transporter. {ECO:0000250}. |
| Q8NF50 | DOCK8 | S20 | ochoa | Dedicator of cytokinesis protein 8 | Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP (PubMed:22461490, PubMed:28028151). During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC (By similarity). Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane (PubMed:28028151). Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing (PubMed:25762780). {ECO:0000250|UniProtKB:Q8C147, ECO:0000269|PubMed:22461490, ECO:0000269|PubMed:25762780, ECO:0000269|PubMed:28028151}. |
| Q8NFC6 | BOD1L1 | S266 | ochoa | Biorientation of chromosomes in cell division protein 1-like 1 | Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}. |
| Q8NI08 | NCOA7 | S366 | ochoa | Nuclear receptor coactivator 7 (140 kDa estrogen receptor-associated protein) (Estrogen nuclear receptor coactivator 1) | Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA. {ECO:0000269|PubMed:11971969}. |
| Q8NI08 | NCOA7 | S608 | ochoa | Nuclear receptor coactivator 7 (140 kDa estrogen receptor-associated protein) (Estrogen nuclear receptor coactivator 1) | Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA. {ECO:0000269|PubMed:11971969}. |
| Q8TDB6 | DTX3L | S548 | ochoa | E3 ubiquitin-protein ligase DTX3L (EC 2.3.2.27) (B-lymphoma- and BAL-associated protein) (Protein deltex-3-like) (RING-type E3 ubiquitin transferase DTX3L) (Rhysin-2) (Rhysin2) | E3 ubiquitin-protein ligase which, in association with ADP-ribosyltransferase PARP9, plays a role in DNA damage repair and in interferon-mediated antiviral responses (PubMed:12670957, PubMed:19818714, PubMed:23230272, PubMed:26479788). Monoubiquitinates several histones, including histone H2A, H2B, H3 and H4 (PubMed:28525742). In response to DNA damage, mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1) (PubMed:19818714). The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation (H4K20me) (PubMed:19818714). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). By monoubiquitinating histone H2B H2BC9/H2BJ and thereby promoting chromatin remodeling, positively regulates STAT1-dependent interferon-stimulated gene transcription and thus STAT1-mediated control of viral replication (PubMed:26479788). Independently of its catalytic activity, promotes the sorting of chemokine receptor CXCR4 from early endosome to lysosome following CXCL12 stimulation by reducing E3 ligase ITCH activity and thus ITCH-mediated ubiquitination of endosomal sorting complex required for transport ESCRT-0 components HGS and STAM (PubMed:24790097). In addition, required for the recruitment of HGS and STAM to early endosomes (PubMed:24790097). In association with PARP9, plays a role in antiviral responses by mediating 'Lys-48'-linked ubiquitination of encephalomyocarditis virus (EMCV) and human rhinovirus (HRV) C3 proteases and thus promoting their proteasomal-mediated degradation (PubMed:26479788). {ECO:0000269|PubMed:12670957, ECO:0000269|PubMed:19818714, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:24790097, ECO:0000269|PubMed:26479788, ECO:0000269|PubMed:28525742}. |
| Q8TF62 | ATP8B4 | S1168 | ochoa | Probable phospholipid-transporting ATPase IM (EC 7.6.2.1) (ATPase class I type 8B member 4) (P4-ATPase flippase complex alpha subunit ATP8B4) | Component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation also seems to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable). {ECO:0000305}. |
| Q8WYP5 | AHCTF1 | S509 | ochoa | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}. |
| Q92599 | SEPTIN8 | S192 | psp | Septin-8 | Filament-forming cytoskeletal GTPase (By similarity). May play a role in platelet secretion (PubMed:15116257). Seems to participate in the process of SNARE complex formation in synaptic vesicles (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:B0BNF1, ECO:0000269|PubMed:15116257}.; FUNCTION: [Isoform 4]: Stabilizes BACE1 protein levels and promotes the sorting and accumulation of BACE1 to the recycling or endosomal compartments, modulating the beta-amyloidogenic processing of APP. {ECO:0000269|PubMed:27084579}. |
| Q92608 | DOCK2 | S838 | ochoa | Dedicator of cytokinesis protein 2 | Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2. {ECO:0000269|PubMed:21613211}. |
| Q92667 | AKAP1 | S35 | ochoa | A-kinase anchor protein 1, mitochondrial (A-kinase anchor protein 149 kDa) (AKAP 149) (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Protein kinase A-anchoring protein 1) (PRKA1) (Spermatid A-kinase anchor protein 84) (S-AKAP84) | Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane (By similarity). Involved in mitochondrial-mediated antiviral innate immunity (PubMed:31522117). Promotes translocation of NDUFS1 into mitochondria to regulate mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) activity (By similarity). {ECO:0000250|UniProtKB:O08715, ECO:0000269|PubMed:31522117}. |
| Q92785 | DPF2 | S200 | ochoa | Zinc finger protein ubi-d4 (Apoptosis response zinc finger protein) (BRG1-associated factor 45D) (BAF45D) (D4, zinc and double PHD fingers family 2) (Protein requiem) | Plays an active role in transcriptional regulation by binding modified histones H3 and H4 (PubMed:27775714, PubMed:28533407). Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells (PubMed:28533407). Might also have a role in the development and maturation of lymphoid cells (By similarity). Involved in the regulation of non-canonical NF-kappa-B pathway (PubMed:20460684). {ECO:0000250|UniProtKB:Q61103, ECO:0000269|PubMed:20460684, ECO:0000269|PubMed:27775714, ECO:0000269|PubMed:28533407}. |
| Q92854 | SEMA4D | S780 | ochoa | Semaphorin-4D (A8) (BB18) (GR3) (CD antigen CD100) | Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling (PubMed:20877282). Regulates GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity). Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (PubMed:19788569). Promotes the migration of cerebellar granule cells (PubMed:16055703). Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro) (PubMed:8876214). Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway (PubMed:16055703). {ECO:0000250|UniProtKB:O09126, ECO:0000269|PubMed:16055703, ECO:0000269|PubMed:19788569, ECO:0000269|PubMed:20877282, ECO:0000269|PubMed:8876214}. |
| Q93045 | STMN2 | S80 | ochoa | Stathmin-2 (Superior cervical ganglion-10 protein) (Protein SCG10) | Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone (By similarity). {ECO:0000250}. |
| Q96AT1 | KIAA1143 | S68 | ochoa | Uncharacterized protein KIAA1143 | None |
| Q96BD8 | SKA1 | S76 | ochoa | SKA complex subunit 1 (Spindle and kinetochore-associated protein 1) | Component of the SKA complex, a microtubule plus end-binding complex of the outer kinetochore that stabilizes spindle microtubule-kinetochore attachments, promotes alignment of chromosomes at the mitotic spindle equator (chromosome congression) and assists suppression of the spindle assembly checkpoint (PubMed:17093495, PubMed:19289083, PubMed:22371557, PubMed:22483620, PubMed:23085020, PubMed:26981768, PubMed:27697923, PubMed:29487209, PubMed:31804178). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules (PubMed:19289083, PubMed:22483620, PubMed:23085020, PubMed:28479321, PubMed:29487209). The outer kinetochore is made up of the ten-subunit KMN network complex, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components such as the SKA complex; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle (PubMed:17093495, PubMed:19289083, PubMed:23085020, PubMed:28479321, PubMed:29487209). The SKA complex is loaded onto bioriented kinetochores and it facilitates chromosome congression by stabilizing microtubules together with MAPRE1, and end-on attachment of the NDC80 complex to depolymerizing spindle microtubules, thereby assisting the poleward-moving kinetochore in withstanding microtubule pulling forces (PubMed:19289083, PubMed:22371557, PubMed:22454517, PubMed:23085020, PubMed:24413531, PubMed:27697923, PubMed:28479321, PubMed:28495837, PubMed:29487209). The complex associates with dynamic microtubule plus-ends and can track both depolymerizing and elongating microtubules (PubMed:23085020, PubMed:29153323). The complex recruits protein phosphatase 1 (PP1) to the kinetochore in prometaphase and metaphase, to oppose spindle assembly checkpoint signaling and promote the onset of anaphase (PubMed:26981768). In the complex, it mediates interactions with microtubules (PubMed:19289083, PubMed:22483620, PubMed:23085020, PubMed:24413531, PubMed:27667719, PubMed:29153323, PubMed:36592928). It also stimulates AURKB/Aurora B catalytic activity (PubMed:27697923). During meiosis the SKA complex stabilizes the meiotic spindle and is required for its migration to the cortex (By similarity). {ECO:0000250|UniProtKB:Q9CPV1, ECO:0000269|PubMed:17093495, ECO:0000269|PubMed:19289083, ECO:0000269|PubMed:22371557, ECO:0000269|PubMed:22454517, ECO:0000269|PubMed:22483620, ECO:0000269|PubMed:23085020, ECO:0000269|PubMed:24413531, ECO:0000269|PubMed:26981768, ECO:0000269|PubMed:27667719, ECO:0000269|PubMed:27697923, ECO:0000269|PubMed:28479321, ECO:0000269|PubMed:28495837, ECO:0000269|PubMed:29153323, ECO:0000269|PubMed:29487209, ECO:0000269|PubMed:31804178, ECO:0000269|PubMed:36592928}. |
| Q96DR7 | ARHGEF26 | S356 | ochoa | Rho guanine nucleotide exchange factor 26 (SH3 domain-containing guanine exchange factor) | Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry. {ECO:0000269|PubMed:15133129, ECO:0000269|PubMed:17074883, ECO:0000269|PubMed:17875742}. |
| Q96FQ6 | S100A16 | S37 | ochoa | Protein S100-A16 (Aging-associated gene 13 protein) (Protein S100-F) (S100 calcium-binding protein A16) | Calcium-binding protein. Binds one calcium ion per monomer (PubMed:17030513). Can promote differentiation of adipocytes (in vitro) (By similarity). Overexpression in preadipocytes increases their proliferation, enhances adipogenesis and reduces insulin-stimulated glucose uptake (By similarity). {ECO:0000250|UniProtKB:Q9D708, ECO:0000269|PubMed:17030513}. |
| Q96GE4 | CEP95 | S544 | ochoa | Centrosomal protein of 95 kDa (Cep95) (Coiled-coil domain-containing protein 45) | None |
| Q96HC4 | PDLIM5 | S76 | ochoa | PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein) | May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May be required to restrain postsynaptic growth of excitatory synapses. Isoform 1, but not isoform 2, expression favors spine thinning and elongation. {ECO:0000250|UniProtKB:Q62920}. |
| Q96HS1 | PGAM5 | S80 | ochoa | Serine/threonine-protein phosphatase PGAM5, mitochondrial (EC 3.1.3.16) (Bcl-XL-binding protein v68) (Phosphoglycerate mutase family member 5) | Mitochondrial serine/threonine phosphatase that dephosphorylates various substrates and thus plays a role in different biological processes including cellular senescence or mitophagy (PubMed:24746696, PubMed:32439975). Modulates cellular senescence by regulating mitochondrial dynamics. Mechanistically, participates in mitochondrial fission through dephosphorylating DNM1L/DRP1 (PubMed:32439975). Additionally, dephosphorylates MFN2 in a stress-sensitive manner and consequently protects it from ubiquitination and degradation to promote mitochondrial network formation (PubMed:37498743). Regulates mitophagy independent of PARKIN by interacting with and dephosphorylating FUNDC1, which interacts with LC3 (PubMed:24746696). Regulates anti-oxidative response by forming a tertiary complex with KEAP1 and NRF2 (PubMed:18387606). Regulates necroptosis by acting as a RIPK3 target and recruiting the RIPK1-RIPK3-MLKL necrosis 'attack' complex to mitochondria (PubMed:22265414). {ECO:0000269|PubMed:18387606, ECO:0000269|PubMed:19590015, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:24746696, ECO:0000269|PubMed:32439975, ECO:0000269|PubMed:37498743}. |
| Q96L93 | KIF16B | S1100 | ochoa | Kinesin-like protein KIF16B (Sorting nexin-23) | Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. {ECO:0000269|PubMed:15882625}. |
| Q96Q42 | ALS2 | S356 | ochoa | Alsin (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein) (Amyotrophic lateral sclerosis 2 protein) | May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity). {ECO:0000250}. |
| Q99590 | SCAF11 | S588 | ochoa | Protein SCAF11 (CTD-associated SR protein 11) (Renal carcinoma antigen NY-REN-40) (SC35-interacting protein 1) (SR-related and CTD-associated factor 11) (SRSF2-interacting protein) (Serine/arginine-rich splicing factor 2-interacting protein) (Splicing factor, arginine/serine-rich 2-interacting protein) (Splicing regulatory protein 129) (SRrp129) | Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly. {ECO:0000269|PubMed:9447963}. |
| Q99698 | LYST | S1017 | ochoa | Lysosomal-trafficking regulator (Beige homolog) | Adapter protein that regulates and/or fission of intracellular vesicles such as lysosomes (PubMed:11984006, PubMed:25216107). Might regulate trafficking of effectors involved in exocytosis (PubMed:25425525). In cytotoxic T-cells and natural killer (NK) cells, has role in the regulation of size, number and exocytosis of lytic granules (PubMed:26478006). In macrophages and dendritic cells, regulates phagosome maturation by controlling the conversion of early phagosomal compartments into late phagosomes (By similarity). In macrophages and dendritic cells, specifically involved in TLR3- and TLR4-induced production of pro-inflammatory cytokines by regulating the endosomal TLR3- TICAM1/TRIF and TLR4- TICAM1/TRIF signaling pathways (PubMed:27881733). {ECO:0000250|UniProtKB:P97412, ECO:0000269|PubMed:11984006, ECO:0000269|PubMed:25216107, ECO:0000269|PubMed:25425525, ECO:0000269|PubMed:26478006, ECO:0000269|PubMed:27881733}. |
| Q99733 | NAP1L4 | S54 | ochoa | Nucleosome assembly protein 1-like 4 (Nucleosome assembly protein 2) (NAP-2) | Acts as a histone chaperone in nucleosome assembly. {ECO:0000269|PubMed:9325046}. |
| Q99755 | PIP5K1A | S68 | ochoa | Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1-alpha) (PtdIns(4)P-5-kinase 1 alpha) (EC 2.7.1.68) (68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha) (Phosphatidylinositol 4-phosphate 5-kinase type I alpha) (PIP5KIalpha) | Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (PubMed:21477596, PubMed:22942276, PubMed:8955136). PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (PubMed:19158393, PubMed:20660631). PIP5K1A-mediated phosphorylation of PtdIns(4)P is the predominant pathway for PtdIns(4,5)P2 synthesis (By similarity). Can also use phosphatidylinositol (PtdIns) as substrate in vitro (PubMed:22942276). Together with PIP5K1C, is required for phagocytosis, both enzymes regulating different types of actin remodeling at sequential steps (By similarity). Promotes particle ingestion by activating the WAS GTPase-binding protein that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup (By similarity). Together with PIP5K1B, is required, after stimulation by G-protein coupled receptors, for the synthesis of IP3 that will induce stable platelet adhesion (By similarity). Recruited to the plasma membrane by the E-cadherin/beta-catenin complex where it provides the substrate PtdIns(4,5)P2 for the production of PtdIns(3,4,5)P3, IP3 and DAG, that will mobilize internal calcium and drive keratinocyte differentiation (PubMed:19158393). Positively regulates insulin-induced translocation of SLC2A4 to the cell membrane in adipocytes (By similarity). Together with PIP5K1C has a role during embryogenesis (By similarity). Independently of its catalytic activity, is required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of the small GTPase RAC1 to the plasma membrane (PubMed:20660631). Also functions in the nucleus where it acts as an activator of TUT1 adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of mRNAs (PubMed:18288197). {ECO:0000250|UniProtKB:P70182, ECO:0000269|PubMed:18288197, ECO:0000269|PubMed:19158393, ECO:0000269|PubMed:20660631, ECO:0000269|PubMed:21477596, ECO:0000269|PubMed:22942276, ECO:0000269|PubMed:8955136}. |
| Q9BQL6 | FERMT1 | S361 | ochoa | Fermitin family homolog 1 (Kindlerin) (Kindlin syndrome protein) (Kindlin-1) (Unc-112-related protein 1) | Involved in cell adhesion. Contributes to integrin activation. When coexpressed with talin, potentiates activation of ITGA2B. Required for normal keratinocyte proliferation. Required for normal polarization of basal keratinocytes in skin, and for normal cell shape. Required for normal adhesion of keratinocytes to fibronectin and laminin, and for normal keratinocyte migration to wound sites. May mediate TGF-beta 1 signaling in tumor progression. {ECO:0000269|PubMed:14634021, ECO:0000269|PubMed:17012746, ECO:0000269|PubMed:19804783}. |
| Q9BTT0 | ANP32E | S104 | ochoa | Acidic leucine-rich nuclear phosphoprotein 32 family member E (LANP-like protein) (LANP-L) | Histone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AZ1 from the nucleosome: removes H2A.Z/H2AZ1 from its normal sites of deposition, especially from enhancer and insulator regions. Not involved in deposition of H2A.Z/H2AZ1 in the nucleosome. May stabilize the evicted H2A.Z/H2AZ1-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state (PubMed:24463511). Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis. {ECO:0000269|PubMed:24463511}. |
| Q9BUE6 | ISCA1 | S73 | ochoa | Iron-sulfur cluster assembly 1 homolog, mitochondrial (HESB-like domain-containing protein 2) (Iron-sulfur assembly protein IscA) (hIscA) | Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Probably involved in the binding of an intermediate of Fe/S cluster assembly. {ECO:0000269|PubMed:15262227, ECO:0000269|PubMed:22323289}. |
| Q9BUQ8 | DDX23 | S143 | ochoa | Probable ATP-dependent RNA helicase DDX23 (EC 3.6.4.13) (100 kDa U5 snRNP-specific protein) (DEAD box protein 23) (PRP28 homolog) (U5-100kD) | Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation (PubMed:18425142). Independently of its spliceosome formation function, required for the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:28076779). {ECO:0000269|PubMed:18425142, ECO:0000269|PubMed:28076779}. |
| Q9GZZ9 | UBA5 | S381 | ochoa | Ubiquitin-like modifier-activating enzyme 5 (Ubiquitin-activating enzyme 5) (ThiFP1) (UFM1-activating enzyme) (Ubiquitin-activating enzyme E1 domain-containing protein 1) | E1-like enzyme which specifically catalyzes the first step in ufmylation (PubMed:15071506, PubMed:18442052, PubMed:20368332, PubMed:25219498, PubMed:26929408, PubMed:27545674, PubMed:27545681, PubMed:27653677, PubMed:30412706, PubMed:30626644, PubMed:34588452). Activates UFM1 by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a UFM1-E1 thioester and free AMP (PubMed:20368332, PubMed:26929408, PubMed:27653677, PubMed:30412706). Activates UFM1 via a trans-binding mechanism, in which UFM1 interacts with distinct sites in both subunits of the UBA5 homodimer (PubMed:27653677). Trans-binding also promotes stabilization of the UBA5 homodimer, and enhances ATP-binding (PubMed:29295865). Transfer of UFM1 from UBA5 to the E2-like enzyme UFC1 also takes place using a trans mechanism (PubMed:27653677, PubMed:34588452). Ufmylation plays a key role in various processes, such as ribosome recycling, response to DNA damage, interferon response or reticulophagy (also called ER-phagy) (PubMed:30412706, PubMed:32160526, PubMed:35394863). Ufmylation is essential for erythroid differentiation of both megakaryocytes and erythrocytes (By similarity). {ECO:0000250|UniProtKB:Q8VE47, ECO:0000269|PubMed:15071506, ECO:0000269|PubMed:18442052, ECO:0000269|PubMed:20368332, ECO:0000269|PubMed:25219498, ECO:0000269|PubMed:26929408, ECO:0000269|PubMed:27545674, ECO:0000269|PubMed:27545681, ECO:0000269|PubMed:27653677, ECO:0000269|PubMed:29295865, ECO:0000269|PubMed:30412706, ECO:0000269|PubMed:30626644, ECO:0000269|PubMed:32160526, ECO:0000269|PubMed:34588452, ECO:0000269|PubMed:35394863}. |
| Q9H1E3 | NUCKS1 | S40 | ochoa | Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (P1) | Chromatin-associated protein involved in DNA repair by promoting homologous recombination (HR) (PubMed:26323318). Binds double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures, but with less affinity than RAD51AP1 (PubMed:26323318). {ECO:0000269|PubMed:26323318}. |
| Q9H4L7 | SMARCAD1 | S67 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1) (EC 3.6.4.12) (ATP-dependent helicase 1) (hHEL1) | DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing. {ECO:0000269|PubMed:21549307, ECO:0000269|PubMed:22960744}. |
| Q9H582 | ZNF644 | S349 | ochoa | Zinc finger protein 644 (Zinc finger motif enhancer-binding protein 2) (Zep-2) | May be involved in transcriptional regulation. |
| Q9H772 | GREM2 | S55 | ochoa | Gremlin-2 (Cysteine knot superfamily 1, BMP antagonist 2) (DAN domain family member 3) (Protein related to DAN and cerberus) | Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner, and thereby modulates signaling by BMP family members. Contributes to the regulation of embryonic morphogenesis via BMP family members. Antagonizes BMP4-induced suppression of progesterone production in granulosa cells. {ECO:0000250|UniProtKB:O88273}. |
| Q9HBD1 | RC3H2 | S1119 | ochoa | Roquin-2 (EC 2.3.2.27) (Membrane-associated nucleic acid-binding protein) (RING finger and CCCH-type zinc finger domain-containing protein 2) (RING finger protein 164) (RING-type E3 ubiquitin transferase Roquin-2) | Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression. Also recognizes CDE in its own mRNA and in that of paralogous RC3H1, possibly leading to feedback loop regulation (By similarity). miRNA-binding protein that regulates microRNA homeostasis. Enhances DICER-mediated processing of pre-MIR146a but reduces mature MIR146a levels through an increase of 3' end uridylation. Both inhibits ICOS mRNA expression and they may act together to exert the suppression (PubMed:25697406). Acts as a ubiquitin E3 ligase. Pairs with E2 enzymes UBE2B, UBE2D2, UBE2E2, UBE2E3, UBE2G2, UBE2K and UBE2Q2 and produces polyubiquitin chains (PubMed:26489670). Shows the strongest activity when paired with UBE2N:UBE2V1 or UBE2N:UBE2V2 E2 complexes and generate both short and long polyubiquitin chains (PubMed:26489670). Involved in the ubiquitination of MAP3K5 (PubMed:24448648, PubMed:26489670, PubMed:29186683). Able to interact with double-stranded RNA (dsRNA) (PubMed:26489670). {ECO:0000250|UniProtKB:P0C090, ECO:0000269|PubMed:24448648, ECO:0000269|PubMed:26489670, ECO:0000269|PubMed:29186683}. |
| Q9HBM0 | VEZT | S677 | ochoa | Vezatin | Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life. Required for morphogenesis of the preimplantation embryo, and for the implantation process. {ECO:0000250|UniProtKB:Q3ZK22}.; FUNCTION: (Microbial infection) In case of Listeria infection, promotes bacterial internalization by participating in myosin VIIa recruitment to the entry site. {ECO:0000269|PubMed:15090598}. |
| Q9NS28 | RGS18 | S28 | ochoa | Regulator of G-protein signaling 18 (RGS18) | Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-2, G(i) alpha-3 and G(q) alpha. {ECO:0000269|PubMed:11042171, ECO:0000269|PubMed:11955952}. |
| Q9NV58 | RNF19A | S599 | ochoa | E3 ubiquitin-protein ligase RNF19A (EC 2.3.2.31) (Double ring-finger protein) (Dorfin) (RING finger protein 19A) (p38) | E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection. {ECO:0000269|PubMed:11237715, ECO:0000269|PubMed:12145308, ECO:0000269|PubMed:12750386, ECO:0000269|PubMed:15456787, ECO:0000269|PubMed:16513638}. |
| Q9NVA2 | SEPTIN11 | S318 | ochoa | Septin-11 | Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity). During Listeria monocytogenes infection, not required for the bacterial entry process, but restricts its efficacy. {ECO:0000250, ECO:0000269|PubMed:15196925, ECO:0000269|PubMed:19234302, ECO:0000305}. |
| Q9NVV4 | MTPAP | S493 | ochoa | Poly(A) RNA polymerase, mitochondrial (PAP) (EC 2.7.7.19) (PAP-associated domain-containing protein 1) (Polynucleotide adenylyltransferase) (Terminal uridylyltransferase 1) (TUTase 1) (mtPAP) | Polymerase that creates the 3' poly(A) tail of mitochondrial transcripts. Can use all four nucleotides, but has higher activity with ATP and UTP (in vitro). Plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. Might be responsible for the creation of some UAA stop codons which are not encoded in mtDNA. {ECO:0000269|PubMed:15547249, ECO:0000269|PubMed:15769737, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:20970105, ECO:0000269|PubMed:21292163}. |
| Q9NX58 | LYAR | S128 | ochoa | Cell growth-regulating nucleolar protein | Plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs (PubMed:24495227). Also acts at the level of transcription regulation. Along with PRMT5, binds the gamma-globin (HBG1/HBG2) promoter and represses its expression (PubMed:25092918). In neuroblastoma cells, may also repress the expression of oxidative stress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and SNORD41 that encodes a small nucleolar RNA (PubMed:28686580). Preferentially binds to a DNA motif containing 5'-GGTTAT-3' (PubMed:25092918). Negatively regulates the antiviral innate immune response by targeting IRF3 and impairing its DNA-binding activity (PubMed:31413131). In addition, inhibits NF-kappa-B-mediated expression of pro-inflammatory cytokines (PubMed:31413131). Stimulates phagocytosis of photoreceptor outer segments by retinal pigment epithelial cells (By similarity). Prevents nucleolin/NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stem cells (ESCs), which in turn is essential for ESC self-renewal (By similarity). {ECO:0000250|UniProtKB:Q08288, ECO:0000269|PubMed:24495227, ECO:0000269|PubMed:25092918, ECO:0000269|PubMed:28686580, ECO:0000269|PubMed:31413131}. |
| Q9NXG2 | THUMPD1 | S86 | ochoa | THUMP domain-containing protein 1 | Functions as a tRNA-binding adapter to mediate NAT10-dependent tRNA acetylation modifying cytidine to N4-acetylcytidine (ac4C) (PubMed:25653167, PubMed:35196516). {ECO:0000269|PubMed:25653167, ECO:0000269|PubMed:35196516}. |
| Q9NY74 | ETAA1 | S186 | ochoa | Ewing's tumor-associated antigen 1 (Ewing's tumor-associated antigen 16) | Replication stress response protein that accumulates at DNA damage sites and promotes replication fork progression and integrity (PubMed:27601467, PubMed:27723717, PubMed:27723720). Recruited to stalled replication forks via interaction with the RPA complex and directly stimulates ATR kinase activity independently of TOPBP1 (PubMed:27723717, PubMed:27723720, PubMed:30139873). Probably only regulates a subset of ATR targets (PubMed:27723717, PubMed:27723720). {ECO:0000269|PubMed:27601467, ECO:0000269|PubMed:27723717, ECO:0000269|PubMed:27723720, ECO:0000269|PubMed:30139873}. |
| Q9NZ72 | STMN3 | S81 | ochoa | Stathmin-3 (SCG10-like protein) | Exhibits microtubule-destabilizing activity, which is antagonized by STAT3. {ECO:0000250}. |
| Q9NZZ3 | CHMP5 | S26 | ochoa | Charged multivesicular body protein 5 (Chromatin-modifying protein 5) (SNF7 domain-containing protein 2) (Vacuolar protein sorting-associated protein 60) (Vps60) (hVps60) | Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses) (PubMed:14519844). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release (PubMed:14519844). {ECO:0000269|PubMed:14519844}. |
| Q9P0K7 | RAI14 | S318 | ochoa | Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14) | Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier. {ECO:0000250|UniProtKB:Q5U312}. |
| Q9P0L2 | MARK1 | S766 | ochoa | Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (EC 2.7.11.26) (MAP/microtubule affinity-regulating kinase 1) (PAR1 homolog c) (Par-1c) (Par1c) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:17573348, ECO:0000269|PubMed:23666762}. |
| Q9UIF8 | BAZ2B | S1467 | ochoa | Bromodomain adjacent to zinc finger domain protein 2B (hWALp4) | Regulatory subunit of the ATP-dependent BRF-1 and BRF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The BRF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the BRF-5 ISWI chromatin remodeling complex (PubMed:28801535). Chromatin reader protein, which may play a role in transcriptional regulation via interaction with ISWI (By similarity) (PubMed:10662543). Involved in positively modulating the rate of age-related behavioral deterioration (By similarity). Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with histone methyltransferase EHMT1 (By similarity). {ECO:0000250|UniProtKB:A2AUY4, ECO:0000269|PubMed:28801535, ECO:0000303|PubMed:10662543}. |
| Q9UK61 | TASOR | S1558 | ochoa | Protein TASOR (CTCL tumor antigen se89-1) (Retinoblastoma-associated protein RAP140) (Transgene activation suppressor protein) | Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression (PubMed:26022416, PubMed:28581500). The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Plays a crucial role in early embryonic development (By similarity). Involved in the organization of spindle poles and spindle apparatus assembly during zygotic division (By similarity). Plays an important role in maintaining epiblast fitness or potency (By similarity). {ECO:0000250|UniProtKB:Q69ZR9, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}. |
| Q9UKX2 | MYH2 | S1205 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9ULW0 | TPX2 | S646 | ochoa | Targeting protein for Xklp2 (Differentially expressed in cancerous and non-cancerous lung cells 2) (DIL-2) (Hepatocellular carcinoma-associated antigen 519) (Hepatocellular carcinoma-associated antigen 90) (Protein fls353) (Restricted expression proliferation-associated protein 100) (p100) | Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764, PubMed:37728657). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activate AURKA kinase and stimulate local microtubule nucleation (PubMed:26165940). {ECO:0000269|PubMed:18663142, ECO:0000269|PubMed:19208764, ECO:0000269|PubMed:26165940}. |
| Q9UMS6 | SYNPO2 | S310 | ochoa | Synaptopodin-2 (Genethonin-2) (Myopodin) | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. |
| Q9UPQ0 | LIMCH1 | S377 | ochoa | LIM and calponin homology domains-containing protein 1 | Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269|PubMed:28228547}. |
| Q9UPU7 | TBC1D2B | S360 | ochoa | TBC1 domain family member 2B | GTPase-activating protein that plays a role in the early steps of endocytosis (PubMed:32623794). {ECO:0000269|PubMed:32623794}. |
| Q9UPY3 | DICER1 | S1015 | ochoa | Endoribonuclease Dicer (EC 3.1.26.3) (Helicase with RNase motif) (Helicase MOI) | Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes. {ECO:0000269|PubMed:15242644, ECO:0000269|PubMed:15973356, ECO:0000269|PubMed:16142218, ECO:0000269|PubMed:16271387, ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:16357216, ECO:0000269|PubMed:16424907, ECO:0000269|PubMed:17452327, ECO:0000269|PubMed:18178619}. |
| Q9Y485 | DMXL1 | S465 | ochoa | DmX-like protein 1 (X-like 1 protein) | None |
| Q9Y4G6 | TLN2 | S1032 | ochoa | Talin-2 | As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity (By similarity). {ECO:0000250}. |
| Q9Y5B6 | PAXBP1 | S154 | ochoa | PAX3- and PAX7-binding protein 1 (GC-rich sequence DNA-binding factor 1) | Adapter protein linking the transcription factors PAX3 and PAX7 to the histone methylation machinery and involved in myogenesis. Associates with a histone methyltransferase complex that specifically mediates dimethylation and trimethylation of 'Lys-4' of histone H3. Mediates the recruitment of that complex to the transcription factors PAX3 and PAX7 on chromatin to regulate the expression of genes involved in muscle progenitor cells proliferation including ID3 and CDC20. {ECO:0000250|UniProtKB:P58501}. |
| Q9Y5X3 | SNX5 | S193 | ochoa | Sorting nexin-5 | Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) (PubMed:15561769). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Involved in retrograde transport of lysosomal enzyme receptor IGF2R (PubMed:17148574, PubMed:18596235). May function as link between endosomal transport vesicles and dynactin (Probable). Plays a role in the internalization of EGFR after EGF stimulation (Probable). Involved in EGFR endosomal sorting and degradation; the function involves PIP5K1C isoform 3 and is retromer-independent (PubMed:23602387). Together with PIP5K1C isoform 3 facilitates HGS interaction with ubiquitinated EGFR, which initiates EGFR sorting to intraluminal vesicles (ILVs) of the multivesicular body for subsequent lysosomal degradation (Probable). Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed:24610942). Plays a role in macropinocytosis (PubMed:18854019, PubMed:21048941). {ECO:0000269|PubMed:18854019, ECO:0000269|PubMed:21048941, ECO:0000269|PubMed:24610942, ECO:0000303|PubMed:15561769, ECO:0000303|PubMed:19619496, ECO:0000303|PubMed:23085988}. |
| Q9Y617 | PSAT1 | S38 | ochoa | Phosphoserine aminotransferase (EC 2.6.1.52) (Phosphohydroxythreonine aminotransferase) (PSAT) | Involved in L-serine biosynthesis via the phosphorylated pathway, a three-step pathway converting the glycolytic intermediate 3-phospho-D-glycerate into L-serine. Catalyzes the second step, that is the pyridoxal 5'-phosphate-dependent transamination of 3-phosphohydroxypyruvate and L-glutamate to O-phosphoserine (OPS) and alpha-ketoglutarate. {ECO:0000269|PubMed:36851825, ECO:0000269|PubMed:37627284}. |
| Q9Y657 | SPIN1 | S109 | psp | Spindlin-1 (Ovarian cancer-related protein) (Spindlin1) | Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and 'Lys-9' (H3K4me3K9me3) and is involved in piRNA-mediated retrotransposon silencing during spermatogenesis (PubMed:33574238). Plays a key role in the initiation of the PIWIL4-piRNA pathway, a pathway that directs transposon DNA methylation and silencing in the male embryonic germ cells, by promoting recruitment of DNA methylation machinery to transposons: binds young, but not old, LINE1 transposons, which are specifically marked with H3K4me3K9me3, and promotes the recruitment of PIWIL4 and SPOCD1 to transposons, leading to piRNA-directed DNA methylation (By similarity). Also recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2 (PubMed:22258766, PubMed:29061846). In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed:21960006). May play a role in cell-cycle regulation during the transition from gamete to embryo (By similarity). Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption (By similarity). {ECO:0000250|UniProtKB:Q61142, ECO:0000269|PubMed:21960006, ECO:0000269|PubMed:22258766, ECO:0000269|PubMed:24589551, ECO:0000269|PubMed:29061846, ECO:0000269|PubMed:33574238}. |
| Q9Y6Q9 | NCOA3 | S601 | psp | Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. |
| R4GMW8 | BIVM-ERCC5 | S1486 | ochoa | DNA excision repair protein ERCC-5 | None |
| O43423 | ANP32CP | S100 | Sugiyama | Putative uncharacterized protein ANP32CP (Acidic leucine-rich nuclear phosphoprotein 32 family member C) (Phosphoprotein 32-related protein 1) (Tumorigenic protein pp32r1) | None |
| O95626 | ANP32D | S104 | Sugiyama | Acidic leucine-rich nuclear phosphoprotein 32 family member D (Phosphoprotein 32-related protein 2) (Tumorigenic protein pp32r2) | None |
| P14854 | COX6B1 | S52 | Sugiyama | Cytochrome c oxidase subunit 6B1 (Cytochrome c oxidase subunit VIb isoform 1) (COX VIb-1) | Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:Q01519}. |
| P39687 | ANP32A | S104 | Sugiyama | Acidic leucine-rich nuclear phosphoprotein 32 family member A (Acidic nuclear phosphoprotein pp32) (pp32) (Leucine-rich acidic nuclear protein) (LANP) (Mapmodulin) (Potent heat-stable protein phosphatase 2A inhibitor I1PP2A) (Putative HLA-DR-associated protein I) (PHAPI) | Multifunctional protein that is involved in the regulation of many processes including tumor suppression, apoptosis, cell cycle progression or transcription (PubMed:10400610, PubMed:11360199, PubMed:16341127, PubMed:18439902). Promotes apoptosis by favouring the activation of caspase-9/CASP9 and allowing apoptosome formation (PubMed:18439902). In addition, plays a role in the modulation of histone acetylation and transcription as part of the INHAT (inhibitor of histone acetyltransferases) complex. Inhibits the histone-acetyltranferase activity of EP300/CREBBP (CREB-binding protein) and EP300/CREBBP-associated factor by histone masking (PubMed:11830591). Preferentially binds to unmodified histone H3 and sterically inhibiting its acetylation and phosphorylation leading to cell growth inhibition (PubMed:16341127). Participates in other biochemical processes such as regulation of mRNA nuclear-to-cytoplasmic translocation and stability by its association with ELAVL1 (Hu-antigen R) (PubMed:18180367). Plays a role in E4F1-mediated transcriptional repression as well as inhibition of protein phosphatase 2A (PubMed:15642345, PubMed:17557114). {ECO:0000269|PubMed:10400610, ECO:0000269|PubMed:11360199, ECO:0000269|PubMed:11830591, ECO:0000269|PubMed:15642345, ECO:0000269|PubMed:16341127, ECO:0000269|PubMed:17557114, ECO:0000269|PubMed:18180367, ECO:0000269|PubMed:18439902}.; FUNCTION: (Microbial infection) Plays an essential role in influenza A, B and C viral genome replication (PubMed:30666459, PubMed:32694517, PubMed:33045004, PubMed:33208942). Mechanistically, mediates the assembly of the viral replicase asymmetric dimers composed of PB1, PB2 and PA via its N-terminal region (PubMed:33208942). Also plays an essential role in foamy virus mRNA export from the nucleus (PubMed:21159877). {ECO:0000269|PubMed:21159877, ECO:0000269|PubMed:30666459, ECO:0000269|PubMed:32694517, ECO:0000269|PubMed:33045004, ECO:0000269|PubMed:33208942}. |
| P30533 | LRPAP1 | S230 | Sugiyama | Alpha-2-macroglobulin receptor-associated protein (Alpha-2-MRAP) (Low density lipoprotein receptor-related protein-associated protein 1) (RAP) | Molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway. {ECO:0000269|PubMed:32296178, ECO:0000269|PubMed:7774585}. |
| P26639 | TARS1 | S522 | Sugiyama | Threonine--tRNA ligase 1, cytoplasmic (EC 6.1.1.3) (Threonyl-tRNA synthetase) (ThrRS) (Threonyl-tRNA synthetase 1) | Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) (PubMed:25824639, PubMed:31374204). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage (By similarity). {ECO:0000250|UniProtKB:Q9D0R2, ECO:0000269|PubMed:25824639, ECO:0000269|PubMed:31374204}. |
| P29144 | TPP2 | S176 | Sugiyama | Tripeptidyl-peptidase 2 (TPP-2) (EC 3.4.14.10) (Tripeptidyl aminopeptidase) (Tripeptidyl-peptidase II) (TPP-II) | Cytosolic tripeptidyl-peptidase that releases N-terminal tripeptides from polypeptides and is a component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway (PubMed:25525876, PubMed:30533531). It plays an important role in intracellular amino acid homeostasis (PubMed:25525876). Stimulates adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q64514, ECO:0000269|PubMed:25525876, ECO:0000269|PubMed:30533531}. |
| P52907 | CAPZA1 | S215 | Sugiyama | F-actin-capping protein subunit alpha-1 (CapZ alpha-1) | F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions (PubMed:22891260). Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:A0PFK5, ECO:0000269|PubMed:22891260}. |
| P61024 | CKS1B | S39 | Sugiyama | Cyclin-dependent kinases regulatory subunit 1 (CKS-1) | Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. |
| Q6NVY1 | HIBCH | S242 | Sugiyama | 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial (EC 3.1.2.4) (3-hydroxyisobutyryl-coenzyme A hydrolase) (HIB-CoA hydrolase) (HIBYL-CoA-H) | Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA. {ECO:0000269|PubMed:8824301}. |
| Q8NBS9 | TXNDC5 | S285 | Sugiyama | Thioredoxin domain-containing protein 5 (EC 1.8.4.-) (EC 5.3.4.1) (Endoplasmic reticulum resident protein 46) (ER protein 46) (ERp46) (Thioredoxin-like protein p46) | Protein disulfide isomerase of the endoplasmic reticulum lumen involved in the formation of disulfide bonds in proteins. Can reduce insulin disulfide bonds. {ECO:0000250|UniProtKB:Q91W90}. |
| Q92688 | ANP32B | S104 | Sugiyama | Acidic leucine-rich nuclear phosphoprotein 32 family member B (Acidic protein rich in leucines) (Putative HLA-DR-associated protein I-2) (PHAPI2) (Silver-stainable protein SSP29) | Multifunctional protein that is involved in the regulation of many processes including cell proliferation, apoptosis, cell cycle progression or transcription (PubMed:18039846, PubMed:20015864). Regulates the proliferation of neuronal stem cells, differentiation of leukemic cells and progression from G1 to S phase of the cell cycle. As negative regulator of caspase-3-dependent apoptosis, may act as an antagonist of ANP32A in regulating tissue homeostasis (PubMed:20015864). Exhibits histone chaperone properties, able to recruit histones to certain promoters, thus regulating the transcription of specific genes (PubMed:18039846, PubMed:20538007). Also plays an essential role in the nucleocytoplasmic transport of specific mRNAs via the uncommon nuclear mRNA export receptor XPO1/CRM1 (PubMed:17178712). Participates in the regulation of adequate adaptive immune responses by acting on mRNA expression and cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q9EST5, ECO:0000269|PubMed:17178712, ECO:0000269|PubMed:18039846, ECO:0000269|PubMed:20015864, ECO:0000269|PubMed:20538007}.; FUNCTION: (Microbial infection) Plays an essential role in influenza A and B viral genome replication (PubMed:31217244, PubMed:33045004). Also plays a role in foamy virus mRNA export from the nucleus to the cytoplasm (PubMed:21159877). {ECO:0000269|PubMed:21159877, ECO:0000269|PubMed:31217244, ECO:0000269|PubMed:33045004}. |
| P29084 | GTF2E2 | S211 | Sugiyama | Transcription initiation factor IIE subunit beta (TFIIE-beta) (General transcription factor IIE subunit 2) | Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. {ECO:0000269|PubMed:1956398, ECO:0000269|PubMed:1956404}. |
| P13639 | EEF2 | Y634 | Sugiyama | Elongation factor 2 (EF-2) (EC 3.6.5.-) | Catalyzes the GTP-dependent ribosomal translocation step during translation elongation (PubMed:26593721). During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively (PubMed:26593721). Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (PubMed:26593721). {ECO:0000269|PubMed:26593721}. |
| O75582 | RPS6KA5 | S517 | Sugiyama | Ribosomal protein S6 kinase alpha-5 (S6K-alpha-5) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 5) (Nuclear mitogen- and stress-activated protein kinase 1) (RSK-like protein kinase) (RSKL) | Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes (PubMed:11909979, PubMed:12569367, PubMed:12763138, PubMed:18511904, PubMed:9687510, PubMed:9873047). Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin (PubMed:11909979, PubMed:9873047). Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression (PubMed:12628924, PubMed:18511904). In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress (PubMed:12628924). In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential (PubMed:12763138). Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation (PubMed:12569367). Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A (PubMed:15010469). Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN (PubMed:12773393). May also phosphorylate 'Ser-28' of histone H3 (PubMed:12773393). Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14) (PubMed:12773393). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines (By similarity). Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors (By similarity). Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury (By similarity). Phosphorylates TRIM7 at 'Ser-107' in response to growth factor signaling via the MEK/ERK pathway, thereby stimulating its ubiquitin ligase activity (PubMed:25851810). {ECO:0000250|UniProtKB:Q8C050, ECO:0000269|PubMed:11909979, ECO:0000269|PubMed:12569367, ECO:0000269|PubMed:12628924, ECO:0000269|PubMed:12763138, ECO:0000269|PubMed:12773393, ECO:0000269|PubMed:15010469, ECO:0000269|PubMed:18511904, ECO:0000269|PubMed:25851810, ECO:0000269|PubMed:9687510, ECO:0000269|PubMed:9873047}. |
| Q16719 | KYNU | Y86 | Sugiyama | Kynureninase (EC 3.7.1.3) (L-kynurenine hydrolase) | Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. {ECO:0000269|PubMed:11985583, ECO:0000269|PubMed:17300176, ECO:0000269|PubMed:28792876, ECO:0000269|PubMed:8706755, ECO:0000269|PubMed:9180257}. |
| Q96I99 | SUCLG2 | S98 | Sugiyama | Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial (EC 6.2.1.4) (GTP-specific succinyl-CoA synthetase subunit beta) (G-SCS) (GTPSCS) (Succinyl-CoA synthetase beta-G chain) (SCS-betaG) | GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. {ECO:0000255|HAMAP-Rule:MF_03221}. |
| Q9UL25 | RAB21 | S143 | Sugiyama | Ras-related protein Rab-21 (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:18804435, PubMed:25648148, PubMed:31455601). RAB21 is involved in membrane trafficking control (PubMed:18804435, PubMed:25648148). During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis (PubMed:18804435). Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general (By similarity). As a result, may regulate cell adhesion and migration (By similarity). Involved in neurite growth (By similarity). Following SBF2/MTMT13-mediated activation in response to starvation-induced autophagy, binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (PubMed:25648148). Modulates protein levels of the cargo receptors TMED2 and TMED10, and required for appropriate Golgi localization of TMED10 (PubMed:31455601). {ECO:0000250|UniProtKB:P35282, ECO:0000250|UniProtKB:Q6AXT5, ECO:0000269|PubMed:18804435, ECO:0000269|PubMed:25648148, ECO:0000269|PubMed:31455601}. |
| Q9NYK5 | MRPL39 | S57 | Sugiyama | Large ribosomal subunit protein mL39 (39S ribosomal protein L39, mitochondrial) (L39mt) (MRP-L39) (39S ribosomal protein L5, mitochondrial) (L5mt) (MRP-L5) | None |
| P51811 | XK | S383 | ELM | Endoplasmic reticulum membrane adapter protein XK (Kell complex 37 kDa component) (Kx antigen) (Membrane transport protein XK) (XK-related protein 1) | Recruits the lipid transfer protein VPS13A from lipid droplets to the endoplasmic reticulum (ER) membrane. {ECO:0000269|PubMed:32845802}. |
| Q9Y3R0 | GRIP1 | S734 | SIGNOR | Glutamate receptor-interacting protein 1 (GRIP-1) | May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons (PubMed:10197531). Through complex formation with NSG1, GRIA2 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity). {ECO:0000250|UniProtKB:P97879, ECO:0000269|PubMed:10197531}. |
| P24752 | ACAT1 | S195 | Sugiyama | Acetyl-CoA acetyltransferase, mitochondrial (EC 2.3.1.9) (Acetoacetyl-CoA thiolase) (T2) | This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (PubMed:1715688, PubMed:7728148, PubMed:9744475). Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms (PubMed:1715688, PubMed:7728148, PubMed:9744475). The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA (PubMed:17371050). Thereby, it plays a major role in ketone body metabolism (PubMed:1715688, PubMed:17371050, PubMed:7728148, PubMed:9744475). {ECO:0000269|PubMed:1715688, ECO:0000269|PubMed:17371050, ECO:0000269|PubMed:7728148, ECO:0000269|PubMed:9744475}. |
| Q9NQ48 | LZTFL1 | S209 | Sugiyama | Leucine zipper transcription factor-like protein 1 | Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function. {ECO:0000269|PubMed:20233871, ECO:0000269|PubMed:22072986, ECO:0000269|PubMed:22510444}. |
| P49959 | MRE11 | S447 | Sugiyama | Double-strand break repair protein MRE11 (EC 3.1.-.-) (Meiotic recombination 11 homolog 1) (MRE11 homolog 1) (Meiotic recombination 11 homolog A) (MRE11 homolog A) | Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:11741547, PubMed:14657032, PubMed:22078559, PubMed:23080121, PubMed:24316220, PubMed:26240375, PubMed:27889449, PubMed:28867292, PubMed:29670289, PubMed:30464262, PubMed:30612738, PubMed:31353207, PubMed:37696958, PubMed:38128537, PubMed:9590181, PubMed:9651580, PubMed:9705271). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (PubMed:24316220, PubMed:28867292, PubMed:31353207, PubMed:38128537). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (PubMed:24316220, PubMed:27889449, PubMed:28867292, PubMed:36050397, PubMed:38128537). Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity (PubMed:11741547, PubMed:22078559, PubMed:24316220, PubMed:26240375, PubMed:27889449, PubMed:29670289, PubMed:31353207, PubMed:36563124, PubMed:9590181, PubMed:9651580, PubMed:9705271). After DSBs, MRE11 is loaded onto DSBs sites and cleaves DNA by cooperating with RBBP8/CtIP to initiate end resection (PubMed:27814491, PubMed:27889449, PubMed:30787182). MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR (PubMed:24316220). It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation to create entry sites for EXO1- and DNA2-mediated 5' to 3' long-range resection, which is required for single-strand invasion and recombination (PubMed:24316220, PubMed:28867292). RBBP8/CtIP specifically promotes the endonuclease activity of MRE11 to clear protein-DNA adducts and generate clean double-strand break ends (PubMed:27814491, PubMed:27889449, PubMed:30787182). MRE11 endonuclease activity is also enhanced by AGER/RAGE (By similarity). The MRN complex is also required for DNA damage signaling via activation of the ATM and ATR kinases: the nuclease activity of MRE11 is not required to activate ATM and ATR (PubMed:14657032, PubMed:15064416, PubMed:15790808, PubMed:16622404). The MRN complex is also required for the processing of R-loops (PubMed:31537797). The MRN complex is involved in the activation of the cGAS-STING pathway induced by DNA damage during tumorigenesis: the MRN complex acts by displacing CGAS from nucleosome sequestration, thereby activating it (By similarity). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888). {ECO:0000250|UniProtKB:Q61216, ECO:0000269|PubMed:10888888, ECO:0000269|PubMed:11741547, ECO:0000269|PubMed:14657032, ECO:0000269|PubMed:15064416, ECO:0000269|PubMed:15790808, ECO:0000269|PubMed:16622404, ECO:0000269|PubMed:22078559, ECO:0000269|PubMed:23080121, ECO:0000269|PubMed:24316220, ECO:0000269|PubMed:26240375, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:28867292, ECO:0000269|PubMed:29670289, ECO:0000269|PubMed:30464262, ECO:0000269|PubMed:30612738, ECO:0000269|PubMed:30787182, ECO:0000269|PubMed:31353207, ECO:0000269|PubMed:31537797, ECO:0000269|PubMed:36050397, ECO:0000269|PubMed:36563124, ECO:0000269|PubMed:37696958, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9590181, ECO:0000269|PubMed:9651580, ECO:0000269|PubMed:9705271}.; FUNCTION: MRE11 contains two DNA-binding domains (DBDs), enabling it to bind both single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). {ECO:0000305}. |
| Q8N6H7 | ARFGAP2 | S364 | Sugiyama | ADP-ribosylation factor GTPase-activating protein 2 (ARF GAP 2) (GTPase-activating protein ZNF289) (Zinc finger protein 289) | GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. {ECO:0000269|PubMed:17760859}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.000002 | 5.706 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 0.000002 | 5.643 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.000008 | 5.083 |
| R-HSA-75153 | Apoptotic execution phase | 0.000026 | 4.584 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.000055 | 4.262 |
| R-HSA-3371511 | HSF1 activation | 0.000066 | 4.178 |
| R-HSA-2559583 | Cellular Senescence | 0.000081 | 4.093 |
| R-HSA-3371568 | Attenuation phase | 0.000108 | 3.968 |
| R-HSA-3371556 | Cellular response to heat stress | 0.000305 | 3.515 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.000361 | 3.443 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.000389 | 3.410 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.000586 | 3.232 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.000681 | 3.167 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.000681 | 3.167 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.000681 | 3.167 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.000681 | 3.167 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.000681 | 3.167 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.000847 | 3.072 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.001082 | 2.966 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.001248 | 2.904 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.001498 | 2.824 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.001498 | 2.824 |
| R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 0.001752 | 2.757 |
| R-HSA-8951911 | RUNX3 regulates RUNX1-mediated transcription | 0.001843 | 2.734 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.001968 | 2.706 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.002493 | 2.603 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.002320 | 2.635 |
| R-HSA-912446 | Meiotic recombination | 0.002461 | 2.609 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.002128 | 2.672 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.002430 | 2.614 |
| R-HSA-1475029 | Reversible hydration of carbon dioxide | 0.002493 | 2.603 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.002836 | 2.547 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.003409 | 2.467 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.003409 | 2.467 |
| R-HSA-2262752 | Cellular responses to stress | 0.003363 | 2.473 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.003727 | 2.429 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.004065 | 2.391 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.004065 | 2.391 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.004423 | 2.354 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.004689 | 2.329 |
| R-HSA-5693538 | Homology Directed Repair | 0.004944 | 2.306 |
| R-HSA-373755 | Semaphorin interactions | 0.005352 | 2.272 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.005716 | 2.243 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.005624 | 2.250 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.006970 | 2.157 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.006699 | 2.174 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.007070 | 2.151 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.008282 | 2.082 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.008698 | 2.061 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 0.008869 | 2.052 |
| R-HSA-199991 | Membrane Trafficking | 0.008909 | 2.050 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.009837 | 2.007 |
| R-HSA-774815 | Nucleosome assembly | 0.009837 | 2.007 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.009601 | 2.018 |
| R-HSA-397014 | Muscle contraction | 0.011103 | 1.955 |
| R-HSA-426117 | Cation-coupled Chloride cotransporters | 0.010839 | 1.965 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 0.010804 | 1.966 |
| R-HSA-9675135 | Diseases of DNA repair | 0.010475 | 1.980 |
| R-HSA-9659379 | Sensory processing of sound | 0.012138 | 1.916 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.012440 | 1.905 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.014034 | 1.853 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.013269 | 1.877 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.014631 | 1.835 |
| R-HSA-1500620 | Meiosis | 0.015739 | 1.803 |
| R-HSA-201451 | Signaling by BMP | 0.015220 | 1.818 |
| R-HSA-162906 | HIV Infection | 0.016040 | 1.795 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.015220 | 1.818 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.016402 | 1.785 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.016402 | 1.785 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.017082 | 1.767 |
| R-HSA-73886 | Chromosome Maintenance | 0.019774 | 1.704 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.021281 | 1.672 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.020512 | 1.688 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.022222 | 1.653 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.022375 | 1.650 |
| R-HSA-418359 | Reduction of cytosolic Ca++ levels | 0.023186 | 1.635 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 0.023186 | 1.635 |
| R-HSA-109581 | Apoptosis | 0.023463 | 1.630 |
| R-HSA-390522 | Striated Muscle Contraction | 0.025063 | 1.601 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 0.026116 | 1.583 |
| R-HSA-1247673 | Erythrocytes take up oxygen and release carbon dioxide | 0.026116 | 1.583 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.026691 | 1.574 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 0.029188 | 1.535 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 0.029188 | 1.535 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.030410 | 1.517 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 0.030575 | 1.515 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 0.030575 | 1.515 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 0.030575 | 1.515 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 0.030575 | 1.515 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 0.030575 | 1.515 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.030603 | 1.514 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.031690 | 1.499 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.035198 | 1.453 |
| R-HSA-1483255 | PI Metabolism | 0.032657 | 1.486 |
| R-HSA-8876725 | Protein methylation | 0.035735 | 1.447 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 0.035735 | 1.447 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 0.035735 | 1.447 |
| R-HSA-6798695 | Neutrophil degranulation | 0.037464 | 1.426 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.040137 | 1.396 |
| R-HSA-9916722 | 3-hydroxyisobutyryl-CoA hydrolase deficiency | 0.045511 | 1.342 |
| R-HSA-9915355 | Beta-ketothiolase deficiency | 0.045511 | 1.342 |
| R-HSA-8964616 | G beta:gamma signalling through CDC42 | 0.042789 | 1.369 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 0.046494 | 1.333 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 0.046494 | 1.333 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.041725 | 1.380 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.041530 | 1.382 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.046219 | 1.335 |
| R-HSA-5619104 | Defective SLC12A1 causes Bartter syndrome 1 (BS1) | 0.060219 | 1.220 |
| R-HSA-8939247 | RUNX1 regulates transcription of genes involved in interleukin signaling | 0.103000 | 0.987 |
| R-HSA-8939245 | RUNX1 regulates transcription of genes involved in BCR signaling | 0.103000 | 0.987 |
| R-HSA-5579028 | Defective CYP17A1 causes AH5 | 0.103000 | 0.987 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.116824 | 0.932 |
| R-HSA-8939256 | RUNX1 regulates transcription of genes involved in WNT signaling | 0.130437 | 0.885 |
| R-HSA-9732724 | IFNG signaling activates MAPKs | 0.143841 | 0.842 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 0.157038 | 0.804 |
| R-HSA-446107 | Type I hemidesmosome assembly | 0.157038 | 0.804 |
| R-HSA-9020958 | Interleukin-21 signaling | 0.170034 | 0.769 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.195428 | 0.709 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 0.207834 | 0.682 |
| R-HSA-416550 | Sema4D mediated inhibition of cell attachment and migration | 0.207834 | 0.682 |
| R-HSA-5358493 | Synthesis of diphthamide-EEF2 | 0.207834 | 0.682 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.220049 | 0.657 |
| R-HSA-8877330 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | 0.232077 | 0.634 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 0.243919 | 0.613 |
| R-HSA-8964315 | G beta:gamma signalling through BTK | 0.255580 | 0.592 |
| R-HSA-73780 | RNA Polymerase III Chain Elongation | 0.255580 | 0.592 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.123550 | 0.908 |
| R-HSA-5083625 | Defective GALNT3 causes HFTC | 0.267062 | 0.573 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 0.144464 | 0.840 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 0.300459 | 0.522 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 0.300459 | 0.522 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 0.300459 | 0.522 |
| R-HSA-418217 | G beta:gamma signalling through PLC beta | 0.300459 | 0.522 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.166045 | 0.780 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 0.171525 | 0.766 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.311252 | 0.507 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.105978 | 0.975 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.321878 | 0.492 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.342643 | 0.465 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.239016 | 0.622 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.184486 | 0.734 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.284766 | 0.546 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.330252 | 0.481 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.089084 | 1.050 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.256951 | 0.590 |
| R-HSA-8931987 | RUNX1 regulates estrogen receptor mediated transcription | 0.143841 | 0.842 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.133913 | 0.873 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.244726 | 0.611 |
| R-HSA-397795 | G-protein beta:gamma signalling | 0.123550 | 0.908 |
| R-HSA-9664873 | Pexophagy | 0.182829 | 0.738 |
| R-HSA-8854691 | Interleukin-20 family signaling | 0.075362 | 1.123 |
| R-HSA-202040 | G-protein activation | 0.332341 | 0.478 |
| R-HSA-8983432 | Interleukin-15 signaling | 0.220049 | 0.657 |
| R-HSA-167172 | Transcription of the HIV genome | 0.115768 | 0.936 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 0.070953 | 1.149 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.278367 | 0.555 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.166045 | 0.780 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.212059 | 0.674 |
| R-HSA-8939242 | RUNX1 regulates transcription of genes involved in differentiation of keratinocy... | 0.157038 | 0.804 |
| R-HSA-164940 | Nef mediated downregulation of MHC class I complex cell surface expression | 0.157038 | 0.804 |
| R-HSA-392170 | ADP signalling through P2Y purinoceptor 12 | 0.332341 | 0.478 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.172981 | 0.762 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.269427 | 0.570 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.269427 | 0.570 |
| R-HSA-6788467 | IL-6-type cytokine receptor ligand interactions | 0.232077 | 0.634 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.204957 | 0.688 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.204957 | 0.688 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.204957 | 0.688 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.273328 | 0.563 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.136306 | 0.865 |
| R-HSA-1059683 | Interleukin-6 signaling | 0.232077 | 0.634 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.155181 | 0.809 |
| R-HSA-8849473 | PTK6 Expression | 0.143841 | 0.842 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.149803 | 0.824 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.177036 | 0.752 |
| R-HSA-72086 | mRNA Capping | 0.103475 | 0.985 |
| R-HSA-9020558 | Interleukin-2 signaling | 0.195428 | 0.709 |
| R-HSA-203927 | MicroRNA (miRNA) biogenesis | 0.084431 | 1.073 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.176793 | 0.753 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 0.116824 | 0.932 |
| R-HSA-426486 | Small interfering RNA (siRNA) biogenesis | 0.130437 | 0.885 |
| R-HSA-392851 | Prostacyclin signalling through prostacyclin receptor | 0.311252 | 0.507 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.273602 | 0.563 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.089084 | 1.050 |
| R-HSA-8984722 | Interleukin-35 Signalling | 0.220049 | 0.657 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.177036 | 0.752 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.166045 | 0.780 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.204957 | 0.688 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 0.342643 | 0.465 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.278367 | 0.555 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.101634 | 0.993 |
| R-HSA-8985947 | Interleukin-9 signaling | 0.157038 | 0.804 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.084431 | 1.073 |
| R-HSA-9708296 | tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis | 0.060219 | 1.220 |
| R-HSA-8941333 | RUNX2 regulates genes involved in differentiation of myeloid cells | 0.088959 | 1.051 |
| R-HSA-199920 | CREB phosphorylation | 0.130437 | 0.885 |
| R-HSA-68952 | DNA replication initiation | 0.182829 | 0.738 |
| R-HSA-192814 | vRNA Synthesis | 0.195428 | 0.709 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 0.207834 | 0.682 |
| R-HSA-877312 | Regulation of IFNG signaling | 0.220049 | 0.657 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.093811 | 1.028 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.255580 | 0.592 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.144464 | 0.840 |
| R-HSA-500657 | Presynaptic function of Kainate receptors | 0.300459 | 0.522 |
| R-HSA-3000480 | Scavenging by Class A Receptors | 0.177036 | 0.752 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 0.321878 | 0.492 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 0.342643 | 0.465 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 0.352787 | 0.452 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.335889 | 0.474 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.182573 | 0.739 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.132799 | 0.877 |
| R-HSA-9020956 | Interleukin-27 signaling | 0.182829 | 0.738 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.109204 | 0.962 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.215515 | 0.667 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.171525 | 0.766 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.296187 | 0.528 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.228552 | 0.641 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.228552 | 0.641 |
| R-HSA-9664407 | Parasite infection | 0.228552 | 0.641 |
| R-HSA-73894 | DNA Repair | 0.140049 | 0.854 |
| R-HSA-162587 | HIV Life Cycle | 0.057082 | 1.244 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.243919 | 0.613 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.255580 | 0.592 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 0.321878 | 0.492 |
| R-HSA-193048 | Androgen biosynthesis | 0.342643 | 0.465 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 0.352787 | 0.452 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.352714 | 0.453 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.096534 | 1.015 |
| R-HSA-9027284 | Erythropoietin activates RAS | 0.255580 | 0.592 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.157981 | 0.801 |
| R-HSA-449147 | Signaling by Interleukins | 0.133177 | 0.876 |
| R-HSA-68882 | Mitotic Anaphase | 0.163391 | 0.787 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 0.130437 | 0.885 |
| R-HSA-112411 | MAPK1 (ERK2) activation | 0.170034 | 0.769 |
| R-HSA-77108 | Utilization of Ketone Bodies | 0.195428 | 0.709 |
| R-HSA-9754706 | Atorvastatin ADME | 0.267062 | 0.573 |
| R-HSA-9710421 | Defective pyroptosis | 0.188136 | 0.726 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 0.332341 | 0.478 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.150640 | 0.822 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.165589 | 0.781 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.102790 | 0.988 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.070472 | 1.152 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.341739 | 0.466 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.183101 | 0.737 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.060926 | 1.215 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.357781 | 0.446 |
| R-HSA-211000 | Gene Silencing by RNA | 0.281971 | 0.550 |
| R-HSA-5578775 | Ion homeostasis | 0.078762 | 1.104 |
| R-HSA-390650 | Histamine receptors | 0.074700 | 1.127 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 0.170034 | 0.769 |
| R-HSA-5676934 | Protein repair | 0.255580 | 0.592 |
| R-HSA-198753 | ERK/MAPK targets | 0.332341 | 0.478 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.256161 | 0.591 |
| R-HSA-844456 | The NLRP3 inflammasome | 0.054240 | 1.266 |
| R-HSA-3928664 | Ephrin signaling | 0.300459 | 0.522 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.096534 | 1.015 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.171525 | 0.766 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.216260 | 0.665 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.352714 | 0.453 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.065596 | 1.183 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.171525 | 0.766 |
| R-HSA-1237044 | Erythrocytes take up carbon dioxide and release oxygen | 0.054240 | 1.266 |
| R-HSA-110056 | MAPK3 (ERK1) activation | 0.182829 | 0.738 |
| R-HSA-428540 | Activation of RAC1 | 0.207834 | 0.682 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 0.220049 | 0.657 |
| R-HSA-418890 | Role of second messengers in netrin-1 signaling | 0.220049 | 0.657 |
| R-HSA-190372 | FGFR3c ligand binding and activation | 0.243919 | 0.613 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.078762 | 1.104 |
| R-HSA-1474165 | Reproduction | 0.079000 | 1.102 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.239016 | 0.622 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.301887 | 0.520 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.155271 | 0.809 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.347121 | 0.460 |
| R-HSA-68877 | Mitotic Prometaphase | 0.234968 | 0.629 |
| R-HSA-379724 | tRNA Aminoacylation | 0.284766 | 0.546 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.100799 | 0.997 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.118445 | 0.926 |
| R-HSA-416700 | Other semaphorin interactions | 0.255580 | 0.592 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.204957 | 0.688 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.204957 | 0.688 |
| R-HSA-1480926 | O2/CO2 exchange in erythrocytes | 0.054240 | 1.266 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.300459 | 0.522 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.182573 | 0.739 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.190035 | 0.721 |
| R-HSA-9658195 | Leishmania infection | 0.190035 | 0.721 |
| R-HSA-168256 | Immune System | 0.193986 | 0.712 |
| R-HSA-157579 | Telomere Maintenance | 0.236353 | 0.626 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.344700 | 0.463 |
| R-HSA-8874177 | ATF6B (ATF6-beta) activates chaperones | 0.060219 | 1.220 |
| R-HSA-2660826 | Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | 0.116824 | 0.932 |
| R-HSA-2660825 | Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | 0.116824 | 0.932 |
| R-HSA-164944 | Nef and signal transduction | 0.130437 | 0.885 |
| R-HSA-8964011 | HDL clearance | 0.130437 | 0.885 |
| R-HSA-167590 | Nef Mediated CD4 Down-regulation | 0.143841 | 0.842 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 0.143841 | 0.842 |
| R-HSA-9013700 | NOTCH4 Activation and Transmission of Signal to the Nucleus | 0.170034 | 0.769 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 0.075362 | 1.123 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 0.075362 | 1.123 |
| R-HSA-9854311 | Maturation of TCA enzymes and regulation of TCA cycle | 0.166045 | 0.780 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 0.342643 | 0.465 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.220097 | 0.657 |
| R-HSA-450294 | MAP kinase activation | 0.290479 | 0.537 |
| R-HSA-9833110 | RSV-host interactions | 0.269427 | 0.570 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.079856 | 1.098 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 0.089084 | 1.050 |
| R-HSA-9865118 | Diseases of branched-chain amino acid catabolism | 0.089084 | 1.050 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 0.204957 | 0.688 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.093685 | 1.028 |
| R-HSA-622312 | Inflammasomes | 0.098609 | 1.006 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.102790 | 0.988 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.123550 | 0.908 |
| R-HSA-448424 | Interleukin-17 signaling | 0.341513 | 0.467 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.238459 | 0.623 |
| R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer | 0.220049 | 0.657 |
| R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants | 0.220049 | 0.657 |
| R-HSA-190239 | FGFR3 ligand binding and activation | 0.255580 | 0.592 |
| R-HSA-1362409 | Mitochondrial iron-sulfur cluster biogenesis | 0.321878 | 0.492 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 0.352787 | 0.452 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.083892 | 1.076 |
| R-HSA-1640170 | Cell Cycle | 0.063902 | 1.194 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.344942 | 0.462 |
| R-HSA-73884 | Base Excision Repair | 0.200127 | 0.699 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.352714 | 0.453 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.259799 | 0.585 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 0.129325 | 0.888 |
| R-HSA-8934903 | Receptor Mediated Mitophagy | 0.182829 | 0.738 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 0.093811 | 1.028 |
| R-HSA-6814848 | Glycerophospholipid catabolism | 0.243919 | 0.613 |
| R-HSA-9027307 | Biosynthesis of maresin-like SPMs | 0.278367 | 0.555 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.149803 | 0.824 |
| R-HSA-912631 | Regulation of signaling by CBL | 0.311252 | 0.507 |
| R-HSA-9931295 | PD-L1(CD274) glycosylation and translocation to plasma membrane | 0.332341 | 0.478 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.261883 | 0.582 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.265335 | 0.576 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 0.062404 | 1.205 |
| R-HSA-422475 | Axon guidance | 0.266556 | 0.574 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 0.139844 | 0.854 |
| R-HSA-70268 | Pyruvate metabolism | 0.188366 | 0.725 |
| R-HSA-418346 | Platelet homeostasis | 0.277783 | 0.556 |
| R-HSA-418360 | Platelet calcium homeostasis | 0.103475 | 0.985 |
| R-HSA-77111 | Synthesis of Ketone Bodies | 0.321878 | 0.492 |
| R-HSA-977347 | Serine metabolism | 0.342643 | 0.465 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.352787 | 0.452 |
| R-HSA-69481 | G2/M Checkpoints | 0.072126 | 1.142 |
| R-HSA-9675108 | Nervous system development | 0.230118 | 0.638 |
| R-HSA-168249 | Innate Immune System | 0.105795 | 0.976 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.160596 | 0.794 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.261883 | 0.582 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.204593 | 0.689 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.357781 | 0.446 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.324065 | 0.489 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 0.195428 | 0.709 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 0.220049 | 0.657 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 0.220049 | 0.657 |
| R-HSA-194002 | Glucocorticoid biosynthesis | 0.342643 | 0.465 |
| R-HSA-9748787 | Azathioprine ADME | 0.227617 | 0.643 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.296187 | 0.528 |
| R-HSA-9824446 | Viral Infection Pathways | 0.329521 | 0.482 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.145621 | 0.837 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.157038 | 0.804 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.170034 | 0.769 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.066632 | 1.176 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 0.342643 | 0.465 |
| R-HSA-162582 | Signal Transduction | 0.300483 | 0.522 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.180629 | 0.743 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.201579 | 0.696 |
| R-HSA-445144 | Signal transduction by L1 | 0.321878 | 0.492 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.236353 | 0.626 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.131655 | 0.881 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.300459 | 0.522 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.145621 | 0.837 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.122478 | 0.912 |
| R-HSA-70895 | Branched-chain amino acid catabolism | 0.233312 | 0.632 |
| R-HSA-193639 | p75NTR signals via NF-kB | 0.255580 | 0.592 |
| R-HSA-373753 | Nephrin family interactions | 0.321878 | 0.492 |
| R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 0.332341 | 0.478 |
| R-HSA-73887 | Death Receptor Signaling | 0.278981 | 0.554 |
| R-HSA-373760 | L1CAM interactions | 0.145459 | 0.837 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.128707 | 0.890 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.284766 | 0.546 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.122700 | 0.911 |
| R-HSA-8983711 | OAS antiviral response | 0.220049 | 0.657 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 0.352787 | 0.452 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.239016 | 0.622 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.073262 | 1.135 |
| R-HSA-9942503 | Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) | 0.267062 | 0.573 |
| R-HSA-9945266 | Differentiation of T cells | 0.267062 | 0.573 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.277783 | 0.556 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.226186 | 0.646 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.253071 | 0.597 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 0.267062 | 0.573 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.166045 | 0.780 |
| R-HSA-449836 | Other interleukin signaling | 0.311252 | 0.507 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.332503 | 0.478 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 0.160596 | 0.794 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.192266 | 0.716 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.347121 | 0.460 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.341513 | 0.467 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 0.054240 | 1.266 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.118445 | 0.926 |
| R-HSA-8964038 | LDL clearance | 0.352787 | 0.452 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.155181 | 0.809 |
| R-HSA-201556 | Signaling by ALK | 0.160596 | 0.794 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.193723 | 0.713 |
| R-HSA-5357801 | Programmed Cell Death | 0.063408 | 1.198 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 0.362775 | 0.440 |
| R-HSA-392451 | G beta:gamma signalling through PI3Kgamma | 0.362775 | 0.440 |
| R-HSA-74182 | Ketone body metabolism | 0.362775 | 0.440 |
| R-HSA-9937008 | Mitochondrial mRNA modification | 0.362775 | 0.440 |
| R-HSA-879518 | Organic anion transport by SLCO transporters | 0.362775 | 0.440 |
| R-HSA-9018682 | Biosynthesis of maresins | 0.362775 | 0.440 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.363849 | 0.439 |
| R-HSA-8939211 | ESR-mediated signaling | 0.369178 | 0.433 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.369390 | 0.433 |
| R-HSA-8852135 | Protein ubiquitination | 0.369390 | 0.433 |
| R-HSA-917937 | Iron uptake and transport | 0.369390 | 0.433 |
| R-HSA-194138 | Signaling by VEGF | 0.370377 | 0.431 |
| R-HSA-74160 | Gene expression (Transcription) | 0.370640 | 0.431 |
| R-HSA-429947 | Deadenylation of mRNA | 0.372609 | 0.429 |
| R-HSA-428930 | Thromboxane signalling through TP receptor | 0.372609 | 0.429 |
| R-HSA-6783589 | Interleukin-6 family signaling | 0.372609 | 0.429 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.372609 | 0.429 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.372609 | 0.429 |
| R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 0.372609 | 0.429 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.372609 | 0.429 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 0.372609 | 0.429 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.372609 | 0.429 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.372609 | 0.429 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.374912 | 0.426 |
| R-HSA-997272 | Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | 0.382293 | 0.418 |
| R-HSA-1296059 | G protein gated Potassium channels | 0.382293 | 0.418 |
| R-HSA-1296041 | Activation of G protein gated Potassium channels | 0.382293 | 0.418 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.382293 | 0.418 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.382293 | 0.418 |
| R-HSA-382551 | Transport of small molecules | 0.388624 | 0.410 |
| R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | 0.391827 | 0.407 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.391827 | 0.407 |
| R-HSA-3295583 | TRP channels | 0.391827 | 0.407 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 0.391827 | 0.407 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.396794 | 0.401 |
| R-HSA-5576891 | Cardiac conduction | 0.399574 | 0.398 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.401215 | 0.397 |
| R-HSA-171306 | Packaging Of Telomere Ends | 0.401215 | 0.397 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.401215 | 0.397 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 0.401215 | 0.397 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.401215 | 0.397 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.401215 | 0.397 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.401215 | 0.397 |
| R-HSA-977225 | Amyloid fiber formation | 0.402210 | 0.396 |
| R-HSA-983712 | Ion channel transport | 0.404306 | 0.393 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.410458 | 0.387 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.410458 | 0.387 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.410458 | 0.387 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.410458 | 0.387 |
| R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 0.410458 | 0.387 |
| R-HSA-9757110 | Prednisone ADME | 0.410458 | 0.387 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.418319 | 0.378 |
| R-HSA-5334118 | DNA methylation | 0.419560 | 0.377 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 0.419560 | 0.377 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.419560 | 0.377 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.419560 | 0.377 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 0.419560 | 0.377 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.419560 | 0.377 |
| R-HSA-420092 | Glucagon-type ligand receptors | 0.419560 | 0.377 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.419560 | 0.377 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.423640 | 0.373 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.428392 | 0.368 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.428521 | 0.368 |
| R-HSA-456926 | Thrombin signalling through proteinase activated receptors (PARs) | 0.428521 | 0.368 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.428521 | 0.368 |
| R-HSA-68886 | M Phase | 0.435354 | 0.361 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.437345 | 0.359 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.437345 | 0.359 |
| R-HSA-162588 | Budding and maturation of HIV virion | 0.437345 | 0.359 |
| R-HSA-913531 | Interferon Signaling | 0.437866 | 0.359 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.441494 | 0.355 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.442238 | 0.354 |
| R-HSA-156902 | Peptide chain elongation | 0.444668 | 0.352 |
| R-HSA-9663891 | Selective autophagy | 0.444668 | 0.352 |
| R-HSA-1296065 | Inwardly rectifying K+ channels | 0.446033 | 0.351 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.446033 | 0.351 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.446033 | 0.351 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.454587 | 0.342 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 0.454587 | 0.342 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.454587 | 0.342 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.460157 | 0.337 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.463009 | 0.334 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.463009 | 0.334 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.470343 | 0.328 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 0.471303 | 0.327 |
| R-HSA-392518 | Signal amplification | 0.471303 | 0.327 |
| R-HSA-5673000 | RAF activation | 0.471303 | 0.327 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.471303 | 0.327 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.471303 | 0.327 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 0.471303 | 0.327 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.471303 | 0.327 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 0.471303 | 0.327 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.471303 | 0.327 |
| R-HSA-1980145 | Signaling by NOTCH2 | 0.471303 | 0.327 |
| R-HSA-5205647 | Mitophagy | 0.471303 | 0.327 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.475393 | 0.323 |
| R-HSA-69242 | S Phase | 0.476576 | 0.322 |
| R-HSA-381042 | PERK regulates gene expression | 0.479468 | 0.319 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.479468 | 0.319 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.479468 | 0.319 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.487508 | 0.312 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.487508 | 0.312 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.487508 | 0.312 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.487508 | 0.312 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.487508 | 0.312 |
| R-HSA-9845576 | Glycosphingolipid transport | 0.487508 | 0.312 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.487508 | 0.312 |
| R-HSA-1280218 | Adaptive Immune System | 0.491835 | 0.308 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.492225 | 0.308 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 0.495424 | 0.305 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.495424 | 0.305 |
| R-HSA-110331 | Cleavage of the damaged purine | 0.495424 | 0.305 |
| R-HSA-549127 | SLC-mediated transport of organic cations | 0.495424 | 0.305 |
| R-HSA-5663205 | Infectious disease | 0.495660 | 0.305 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.499963 | 0.301 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.500200 | 0.301 |
| R-HSA-73927 | Depurination | 0.503219 | 0.298 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.504483 | 0.297 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.505070 | 0.297 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.505070 | 0.297 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.505070 | 0.297 |
| R-HSA-9612973 | Autophagy | 0.507642 | 0.294 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.510893 | 0.292 |
| R-HSA-69541 | Stabilization of p53 | 0.510893 | 0.292 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.510893 | 0.292 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.518450 | 0.285 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.518450 | 0.285 |
| R-HSA-167169 | HIV Transcription Elongation | 0.518450 | 0.285 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.518450 | 0.285 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.518450 | 0.285 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.518450 | 0.285 |
| R-HSA-71240 | Tryptophan catabolism | 0.518450 | 0.285 |
| R-HSA-202433 | Generation of second messenger molecules | 0.518450 | 0.285 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.524419 | 0.280 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.524647 | 0.280 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 0.525890 | 0.279 |
| R-HSA-5423646 | Aflatoxin activation and detoxification | 0.525890 | 0.279 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.525890 | 0.279 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 0.525890 | 0.279 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.525890 | 0.279 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.531713 | 0.274 |
| R-HSA-167161 | HIV Transcription Initiation | 0.533215 | 0.273 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.533215 | 0.273 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.533215 | 0.273 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.533215 | 0.273 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.533215 | 0.273 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.533215 | 0.273 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.533642 | 0.273 |
| R-HSA-597592 | Post-translational protein modification | 0.537158 | 0.270 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.538069 | 0.269 |
| R-HSA-991365 | Activation of GABAB receptors | 0.540428 | 0.267 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 0.540428 | 0.267 |
| R-HSA-977444 | GABA B receptor activation | 0.540428 | 0.267 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 0.540428 | 0.267 |
| R-HSA-73928 | Depyrimidination | 0.540428 | 0.267 |
| R-HSA-165159 | MTOR signalling | 0.540428 | 0.267 |
| R-HSA-1483257 | Phospholipid metabolism | 0.541645 | 0.266 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.542914 | 0.265 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.544451 | 0.264 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.547530 | 0.262 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.547530 | 0.262 |
| R-HSA-72766 | Translation | 0.550332 | 0.259 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.552057 | 0.258 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.552057 | 0.258 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.554523 | 0.256 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.554523 | 0.256 |
| R-HSA-69236 | G1 Phase | 0.554523 | 0.256 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.554523 | 0.256 |
| R-HSA-375280 | Amine ligand-binding receptors | 0.554523 | 0.256 |
| R-HSA-373752 | Netrin-1 signaling | 0.554523 | 0.256 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.556580 | 0.254 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.561070 | 0.251 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.561070 | 0.251 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.561408 | 0.251 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.561408 | 0.251 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 0.561408 | 0.251 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 0.561408 | 0.251 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.561408 | 0.251 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.561408 | 0.251 |
| R-HSA-15869 | Metabolism of nucleotides | 0.563052 | 0.249 |
| R-HSA-72306 | tRNA processing | 0.563179 | 0.249 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.565529 | 0.248 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.565529 | 0.248 |
| R-HSA-202403 | TCR signaling | 0.565529 | 0.248 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.568187 | 0.246 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.568187 | 0.246 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.568187 | 0.246 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 0.568187 | 0.246 |
| R-HSA-8953854 | Metabolism of RNA | 0.572130 | 0.243 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.573824 | 0.241 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.573824 | 0.241 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.573824 | 0.241 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.574348 | 0.241 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.574861 | 0.240 |
| R-HSA-437239 | Recycling pathway of L1 | 0.574861 | 0.240 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.574861 | 0.240 |
| R-HSA-157118 | Signaling by NOTCH | 0.575265 | 0.240 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.578708 | 0.238 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.578708 | 0.238 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.580831 | 0.236 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.581186 | 0.236 |
| R-HSA-9634597 | GPER1 signaling | 0.581433 | 0.236 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.583036 | 0.234 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.587904 | 0.231 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.587904 | 0.231 |
| R-HSA-73893 | DNA Damage Bypass | 0.587904 | 0.231 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.587904 | 0.231 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.591594 | 0.228 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.591594 | 0.228 |
| R-HSA-2162123 | Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | 0.594275 | 0.226 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.595823 | 0.225 |
| R-HSA-109582 | Hemostasis | 0.598182 | 0.223 |
| R-HSA-1500931 | Cell-Cell communication | 0.598776 | 0.223 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.599455 | 0.222 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.600548 | 0.221 |
| R-HSA-9864848 | Complex IV assembly | 0.600548 | 0.221 |
| R-HSA-2514856 | The phototransduction cascade | 0.600548 | 0.221 |
| R-HSA-4839726 | Chromatin organization | 0.602031 | 0.220 |
| R-HSA-72187 | mRNA 3'-end processing | 0.606724 | 0.217 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.606724 | 0.217 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.606724 | 0.217 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.606724 | 0.217 |
| R-HSA-1643685 | Disease | 0.611443 | 0.214 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.612415 | 0.213 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.612415 | 0.213 |
| R-HSA-1221632 | Meiotic synapsis | 0.612805 | 0.213 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.612805 | 0.213 |
| R-HSA-8956320 | Nucleotide biosynthesis | 0.612805 | 0.213 |
| R-HSA-69275 | G2/M Transition | 0.618053 | 0.209 |
| R-HSA-72649 | Translation initiation complex formation | 0.618792 | 0.208 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 0.618792 | 0.208 |
| R-HSA-5688426 | Deubiquitination | 0.619302 | 0.208 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.620514 | 0.207 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.624515 | 0.204 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.624515 | 0.204 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.624576 | 0.204 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.624688 | 0.204 |
| R-HSA-418597 | G alpha (z) signalling events | 0.624688 | 0.204 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.624688 | 0.204 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.628483 | 0.202 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.630492 | 0.200 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.630492 | 0.200 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 0.630492 | 0.200 |
| R-HSA-177929 | Signaling by EGFR | 0.630492 | 0.200 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.636207 | 0.196 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.637394 | 0.196 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.640192 | 0.194 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.640192 | 0.194 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.640192 | 0.194 |
| R-HSA-69206 | G1/S Transition | 0.640192 | 0.194 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.641593 | 0.193 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.641834 | 0.193 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.641834 | 0.193 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.643688 | 0.191 |
| R-HSA-392499 | Metabolism of proteins | 0.646395 | 0.190 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.647375 | 0.189 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.647375 | 0.189 |
| R-HSA-180786 | Extension of Telomeres | 0.647375 | 0.189 |
| R-HSA-114608 | Platelet degranulation | 0.647837 | 0.189 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.649905 | 0.187 |
| R-HSA-8873719 | RAB geranylgeranylation | 0.652829 | 0.185 |
| R-HSA-977443 | GABA receptor activation | 0.652829 | 0.185 |
| R-HSA-983189 | Kinesins | 0.652829 | 0.185 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.652829 | 0.185 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.652829 | 0.185 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.652829 | 0.185 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.652829 | 0.185 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.652829 | 0.185 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.652829 | 0.185 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.658200 | 0.182 |
| R-HSA-445717 | Aquaporin-mediated transport | 0.658200 | 0.182 |
| R-HSA-1442490 | Collagen degradation | 0.658200 | 0.182 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.659062 | 0.181 |
| R-HSA-1268020 | Mitochondrial protein import | 0.663489 | 0.178 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.668695 | 0.175 |
| R-HSA-8848021 | Signaling by PTK6 | 0.668695 | 0.175 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.668695 | 0.175 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.670827 | 0.173 |
| R-HSA-9679506 | SARS-CoV Infections | 0.673523 | 0.172 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.673583 | 0.172 |
| R-HSA-211981 | Xenobiotics | 0.673822 | 0.171 |
| R-HSA-72172 | mRNA Splicing | 0.676925 | 0.169 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.678869 | 0.168 |
| R-HSA-446728 | Cell junction organization | 0.681045 | 0.167 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.683564 | 0.165 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.683838 | 0.165 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 0.683838 | 0.165 |
| R-HSA-196071 | Metabolism of steroid hormones | 0.688731 | 0.162 |
| R-HSA-913709 | O-linked glycosylation of mucins | 0.693549 | 0.159 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.697785 | 0.156 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.702962 | 0.153 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.702962 | 0.153 |
| R-HSA-1632852 | Macroautophagy | 0.704423 | 0.152 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.707561 | 0.150 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.707561 | 0.150 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 0.707561 | 0.150 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.710856 | 0.148 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.712088 | 0.147 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.712088 | 0.147 |
| R-HSA-9748784 | Drug ADME | 0.715853 | 0.145 |
| R-HSA-418990 | Adherens junctions interactions | 0.715853 | 0.145 |
| R-HSA-4086398 | Ca2+ pathway | 0.716545 | 0.145 |
| R-HSA-9749641 | Aspirin ADME | 0.716545 | 0.145 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.716545 | 0.145 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.720934 | 0.142 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.723613 | 0.140 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.725255 | 0.140 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.728700 | 0.137 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.729509 | 0.137 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.729772 | 0.137 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.735815 | 0.133 |
| R-HSA-6783783 | Interleukin-10 signaling | 0.737822 | 0.132 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.737822 | 0.132 |
| R-HSA-9955298 | SLC-mediated transport of organic anions | 0.737822 | 0.132 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.738794 | 0.131 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 0.741883 | 0.130 |
| R-HSA-5579029 | Metabolic disorders of biological oxidation enzymes | 0.741883 | 0.130 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.741883 | 0.130 |
| R-HSA-69306 | DNA Replication | 0.744665 | 0.128 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.745881 | 0.127 |
| R-HSA-9833482 | PKR-mediated signaling | 0.745881 | 0.127 |
| R-HSA-9018677 | Biosynthesis of DHA-derived SPMs | 0.749817 | 0.125 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.753692 | 0.123 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.755806 | 0.122 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.757508 | 0.121 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.758851 | 0.120 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.764964 | 0.116 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.768606 | 0.114 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 0.772191 | 0.112 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.775721 | 0.110 |
| R-HSA-1266738 | Developmental Biology | 0.780330 | 0.108 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 0.785988 | 0.105 |
| R-HSA-202424 | Downstream TCR signaling | 0.785988 | 0.105 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.792572 | 0.101 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.792572 | 0.101 |
| R-HSA-421270 | Cell-cell junction organization | 0.793187 | 0.101 |
| R-HSA-418555 | G alpha (s) signalling events | 0.795005 | 0.100 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.795005 | 0.100 |
| R-HSA-391251 | Protein folding | 0.795787 | 0.099 |
| R-HSA-212436 | Generic Transcription Pathway | 0.795863 | 0.099 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.798953 | 0.097 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.799761 | 0.097 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.799761 | 0.097 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.802070 | 0.096 |
| R-HSA-1474290 | Collagen formation | 0.802070 | 0.096 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.805139 | 0.094 |
| R-HSA-5389840 | Mitochondrial translation elongation | 0.811135 | 0.091 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.811135 | 0.091 |
| R-HSA-1296071 | Potassium Channels | 0.811135 | 0.091 |
| R-HSA-611105 | Respiratory electron transport | 0.811227 | 0.091 |
| R-HSA-168255 | Influenza Infection | 0.813449 | 0.090 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.816948 | 0.088 |
| R-HSA-5368286 | Mitochondrial translation initiation | 0.816948 | 0.088 |
| R-HSA-422356 | Regulation of insulin secretion | 0.816948 | 0.088 |
| R-HSA-190236 | Signaling by FGFR | 0.816948 | 0.088 |
| R-HSA-416476 | G alpha (q) signalling events | 0.818466 | 0.087 |
| R-HSA-3214847 | HATs acetylate histones | 0.819787 | 0.086 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.819787 | 0.086 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.825334 | 0.083 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.825334 | 0.083 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.825699 | 0.083 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.826112 | 0.083 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 0.830712 | 0.081 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.832421 | 0.080 |
| R-HSA-111885 | Opioid Signalling | 0.833338 | 0.079 |
| R-HSA-5617833 | Cilium Assembly | 0.836394 | 0.078 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.838349 | 0.077 |
| R-HSA-69239 | Synthesis of DNA | 0.843444 | 0.074 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.845874 | 0.073 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.845874 | 0.073 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.845874 | 0.073 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.845874 | 0.073 |
| R-HSA-9609690 | HCMV Early Events | 0.847810 | 0.072 |
| R-HSA-5419276 | Mitochondrial translation termination | 0.848266 | 0.071 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.855223 | 0.068 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.855223 | 0.068 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.855223 | 0.068 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.860213 | 0.065 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.860213 | 0.065 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.861862 | 0.065 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.866118 | 0.062 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.868197 | 0.061 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.868197 | 0.061 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.868362 | 0.061 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.872259 | 0.059 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.874243 | 0.058 |
| R-HSA-68875 | Mitotic Prophase | 0.876197 | 0.057 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.876336 | 0.057 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.883713 | 0.054 |
| R-HSA-8951664 | Neddylation | 0.889367 | 0.051 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.890576 | 0.050 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.892472 | 0.049 |
| R-HSA-9843745 | Adipogenesis | 0.899003 | 0.046 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.900573 | 0.045 |
| R-HSA-72312 | rRNA processing | 0.903569 | 0.044 |
| R-HSA-163685 | Integration of energy metabolism | 0.908067 | 0.042 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.908067 | 0.042 |
| R-HSA-5173105 | O-linked glycosylation | 0.909496 | 0.041 |
| R-HSA-5368287 | Mitochondrial translation | 0.910904 | 0.041 |
| R-HSA-6807070 | PTEN Regulation | 0.912290 | 0.040 |
| R-HSA-5668914 | Diseases of metabolism | 0.918823 | 0.037 |
| R-HSA-9018678 | Biosynthesis of specialized proresolving mediators (SPMs) | 0.918903 | 0.037 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.921102 | 0.036 |
| R-HSA-9609646 | HCMV Infection | 0.923200 | 0.035 |
| R-HSA-2187338 | Visual phototransduction | 0.923835 | 0.034 |
| R-HSA-166520 | Signaling by NTRKs | 0.925020 | 0.034 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.929581 | 0.032 |
| R-HSA-2142753 | Arachidonate metabolism | 0.929581 | 0.032 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.929581 | 0.032 |
| R-HSA-9609507 | Protein localization | 0.930677 | 0.031 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.932819 | 0.030 |
| R-HSA-1989781 | PPARA activates gene expression | 0.932819 | 0.030 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.934895 | 0.029 |
| R-HSA-877300 | Interferon gamma signaling | 0.936907 | 0.028 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.941671 | 0.026 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 0.944355 | 0.025 |
| R-HSA-5619102 | SLC transporter disorders | 0.944355 | 0.025 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.946440 | 0.024 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.947744 | 0.023 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.957400 | 0.019 |
| R-HSA-3781865 | Diseases of glycosylation | 0.958064 | 0.019 |
| R-HSA-195721 | Signaling by WNT | 0.958769 | 0.018 |
| R-HSA-375276 | Peptide ligand-binding receptors | 0.959363 | 0.018 |
| R-HSA-372790 | Signaling by GPCR | 0.965085 | 0.015 |
| R-HSA-388396 | GPCR downstream signalling | 0.965523 | 0.015 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.969191 | 0.014 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.970399 | 0.013 |
| R-HSA-8957322 | Metabolism of steroids | 0.970791 | 0.013 |
| R-HSA-6805567 | Keratinization | 0.970798 | 0.013 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.971519 | 0.013 |
| R-HSA-1474244 | Extracellular matrix organization | 0.973403 | 0.012 |
| R-HSA-112316 | Neuronal System | 0.982345 | 0.008 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.984701 | 0.007 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.988863 | 0.005 |
| R-HSA-418594 | G alpha (i) signalling events | 0.990695 | 0.004 |
| R-HSA-500792 | GPCR ligand binding | 0.996209 | 0.002 |
| R-HSA-211859 | Biological oxidations | 0.998191 | 0.001 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.998441 | 0.001 |
| R-HSA-8978868 | Fatty acid metabolism | 0.998811 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 0.998980 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999935 | 0.000 |
| R-HSA-1430728 | Metabolism | 0.999996 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.772 | 0.103 | 2 | 0.881 |
NDR2 |
0.771 | 0.112 | -3 | 0.835 |
NDR1 |
0.770 | 0.179 | -3 | 0.843 |
TBK1 |
0.769 | 0.129 | 1 | 0.812 |
RSK2 |
0.769 | 0.142 | -3 | 0.774 |
LATS2 |
0.768 | 0.090 | -5 | 0.244 |
PIM3 |
0.768 | 0.124 | -3 | 0.823 |
PIM1 |
0.764 | 0.156 | -3 | 0.796 |
IKKE |
0.764 | 0.091 | 1 | 0.821 |
WNK1 |
0.764 | 0.170 | -2 | 0.863 |
RAF1 |
0.763 | 0.123 | 1 | 0.838 |
P90RSK |
0.762 | 0.105 | -3 | 0.764 |
AMPKA1 |
0.761 | 0.128 | -3 | 0.869 |
P70S6KB |
0.761 | 0.140 | -3 | 0.809 |
RSK4 |
0.760 | 0.160 | -3 | 0.747 |
CLK3 |
0.760 | 0.078 | 1 | 0.718 |
RSK3 |
0.760 | 0.100 | -3 | 0.759 |
PKACG |
0.759 | 0.130 | -2 | 0.751 |
MARK4 |
0.759 | 0.096 | 4 | 0.896 |
IKKB |
0.759 | 0.019 | -2 | 0.712 |
PKN3 |
0.758 | 0.052 | -3 | 0.818 |
MAPKAPK3 |
0.758 | 0.054 | -3 | 0.790 |
CAMK1B |
0.758 | 0.070 | -3 | 0.858 |
AMPKA2 |
0.758 | 0.105 | -3 | 0.847 |
MST4 |
0.757 | 0.128 | 2 | 0.794 |
NUAK2 |
0.757 | 0.069 | -3 | 0.859 |
CDC7 |
0.756 | -0.019 | 1 | 0.742 |
PRKD2 |
0.756 | 0.046 | -3 | 0.796 |
DSTYK |
0.756 | 0.028 | 2 | 0.866 |
TSSK1 |
0.755 | 0.055 | -3 | 0.880 |
PAK6 |
0.755 | 0.135 | -2 | 0.719 |
MAPKAPK2 |
0.755 | 0.060 | -3 | 0.748 |
CAMK2D |
0.755 | 0.053 | -3 | 0.833 |
CAMK2G |
0.754 | 0.069 | 2 | 0.816 |
AURC |
0.754 | 0.105 | -2 | 0.664 |
TSSK2 |
0.754 | 0.033 | -5 | 0.174 |
RIPK3 |
0.754 | 0.021 | 3 | 0.466 |
ULK2 |
0.754 | -0.000 | 2 | 0.789 |
PRKD1 |
0.754 | -0.012 | -3 | 0.804 |
PDHK4 |
0.753 | -0.046 | 1 | 0.813 |
PDHK1 |
0.753 | 0.015 | 1 | 0.840 |
PRPK |
0.753 | -0.011 | -1 | 0.841 |
WNK3 |
0.753 | 0.072 | 1 | 0.772 |
NLK |
0.753 | 0.021 | 1 | 0.760 |
MTOR |
0.752 | -0.016 | 1 | 0.757 |
PKN2 |
0.752 | 0.074 | -3 | 0.853 |
SKMLCK |
0.752 | 0.054 | -2 | 0.840 |
SGK3 |
0.752 | 0.146 | -3 | 0.784 |
PAK1 |
0.752 | 0.115 | -2 | 0.783 |
NIK |
0.751 | 0.109 | -3 | 0.873 |
PKCD |
0.751 | 0.082 | 2 | 0.768 |
PKACB |
0.751 | 0.125 | -2 | 0.692 |
PIM2 |
0.750 | 0.168 | -3 | 0.765 |
LATS1 |
0.750 | 0.103 | -3 | 0.830 |
SRPK1 |
0.750 | 0.040 | -3 | 0.730 |
MELK |
0.750 | 0.091 | -3 | 0.836 |
NIM1 |
0.750 | 0.066 | 3 | 0.511 |
PKG2 |
0.750 | 0.123 | -2 | 0.699 |
PAK3 |
0.750 | 0.097 | -2 | 0.790 |
CAMLCK |
0.749 | 0.058 | -2 | 0.846 |
IKKA |
0.749 | 0.026 | -2 | 0.696 |
GRK6 |
0.749 | 0.119 | 1 | 0.771 |
MNK2 |
0.749 | 0.076 | -2 | 0.804 |
CAMK2B |
0.749 | 0.092 | 2 | 0.790 |
MOS |
0.749 | -0.026 | 1 | 0.756 |
HUNK |
0.748 | 0.019 | 2 | 0.805 |
BCKDK |
0.748 | 0.033 | -1 | 0.798 |
SRPK2 |
0.748 | 0.050 | -3 | 0.663 |
CDKL1 |
0.747 | 0.009 | -3 | 0.771 |
TGFBR2 |
0.747 | 0.009 | -2 | 0.778 |
GCN2 |
0.747 | -0.100 | 2 | 0.788 |
NUAK1 |
0.747 | 0.043 | -3 | 0.821 |
CAMK4 |
0.746 | 0.037 | -3 | 0.852 |
CDKL5 |
0.746 | 0.020 | -3 | 0.765 |
BRSK1 |
0.746 | 0.062 | -3 | 0.810 |
MARK3 |
0.746 | 0.097 | 4 | 0.851 |
PRKX |
0.746 | 0.127 | -3 | 0.740 |
BRSK2 |
0.746 | 0.063 | -3 | 0.844 |
QSK |
0.746 | 0.049 | 4 | 0.879 |
AURB |
0.746 | 0.083 | -2 | 0.662 |
CAMK2A |
0.746 | 0.076 | 2 | 0.786 |
ERK5 |
0.745 | -0.007 | 1 | 0.723 |
BMPR2 |
0.745 | -0.103 | -2 | 0.866 |
FAM20C |
0.745 | 0.080 | 2 | 0.649 |
PLK1 |
0.745 | 0.089 | -2 | 0.818 |
MARK2 |
0.744 | 0.078 | 4 | 0.817 |
DAPK2 |
0.744 | 0.025 | -3 | 0.851 |
QIK |
0.744 | 0.066 | -3 | 0.841 |
CLK1 |
0.744 | 0.071 | -3 | 0.783 |
CHK1 |
0.744 | 0.008 | -3 | 0.842 |
SIK |
0.744 | 0.060 | -3 | 0.787 |
ULK1 |
0.743 | -0.038 | -3 | 0.765 |
ATR |
0.743 | -0.041 | 1 | 0.716 |
PAK2 |
0.743 | 0.088 | -2 | 0.765 |
MYLK4 |
0.743 | 0.072 | -2 | 0.765 |
NEK7 |
0.742 | -0.081 | -3 | 0.782 |
MSK2 |
0.742 | 0.030 | -3 | 0.720 |
ICK |
0.742 | 0.015 | -3 | 0.808 |
MSK1 |
0.742 | 0.051 | -3 | 0.737 |
MNK1 |
0.741 | 0.082 | -2 | 0.812 |
PRKD3 |
0.741 | 0.024 | -3 | 0.760 |
NEK6 |
0.741 | -0.060 | -2 | 0.858 |
GRK1 |
0.741 | 0.024 | -2 | 0.692 |
MARK1 |
0.740 | 0.074 | 4 | 0.866 |
GRK5 |
0.740 | -0.022 | -3 | 0.812 |
CLK4 |
0.740 | 0.055 | -3 | 0.789 |
PHKG1 |
0.740 | 0.039 | -3 | 0.844 |
PKCG |
0.739 | 0.068 | 2 | 0.709 |
KIS |
0.739 | -0.005 | 1 | 0.628 |
PKACA |
0.739 | 0.099 | -2 | 0.649 |
PLK3 |
0.739 | 0.104 | 2 | 0.782 |
NEK9 |
0.739 | -0.042 | 2 | 0.823 |
P70S6K |
0.739 | 0.078 | -3 | 0.714 |
HIPK4 |
0.739 | -0.025 | 1 | 0.671 |
MRCKA |
0.738 | 0.226 | -3 | 0.792 |
PKCB |
0.738 | 0.053 | 2 | 0.715 |
AKT2 |
0.738 | 0.067 | -3 | 0.712 |
PHKG2 |
0.737 | 0.094 | -3 | 0.850 |
TTBK2 |
0.737 | 0.005 | 2 | 0.722 |
MASTL |
0.737 | -0.109 | -2 | 0.796 |
DCAMKL1 |
0.737 | 0.100 | -3 | 0.828 |
ALK4 |
0.737 | 0.044 | -2 | 0.786 |
CHAK2 |
0.736 | -0.045 | -1 | 0.869 |
MLK1 |
0.736 | -0.093 | 2 | 0.786 |
ANKRD3 |
0.736 | -0.036 | 1 | 0.806 |
CLK2 |
0.736 | 0.082 | -3 | 0.770 |
RIPK1 |
0.736 | -0.068 | 1 | 0.732 |
PKCA |
0.736 | 0.042 | 2 | 0.699 |
AURA |
0.735 | 0.046 | -2 | 0.620 |
PAK5 |
0.735 | 0.098 | -2 | 0.647 |
JNK2 |
0.735 | 0.049 | 1 | 0.576 |
SRPK3 |
0.735 | 0.012 | -3 | 0.693 |
GRK7 |
0.735 | 0.130 | 1 | 0.696 |
AKT1 |
0.735 | 0.079 | -3 | 0.740 |
NEK2 |
0.735 | 0.045 | 2 | 0.790 |
DLK |
0.734 | -0.057 | 1 | 0.781 |
SSTK |
0.734 | 0.052 | 4 | 0.863 |
CDK8 |
0.734 | -0.027 | 1 | 0.609 |
CDK7 |
0.734 | -0.001 | 1 | 0.603 |
PKCH |
0.734 | 0.046 | 2 | 0.703 |
PLK4 |
0.733 | 0.041 | 2 | 0.640 |
IRE1 |
0.733 | -0.022 | 1 | 0.684 |
DNAPK |
0.733 | 0.058 | 1 | 0.689 |
IRE2 |
0.732 | 0.004 | 2 | 0.755 |
CK2A2 |
0.732 | 0.241 | 1 | 0.598 |
TGFBR1 |
0.732 | 0.032 | -2 | 0.752 |
WNK4 |
0.732 | 0.049 | -2 | 0.862 |
CAMK1D |
0.732 | 0.057 | -3 | 0.737 |
DYRK2 |
0.731 | -0.007 | 1 | 0.618 |
GRK4 |
0.731 | -0.044 | -2 | 0.758 |
SNRK |
0.731 | -0.016 | 2 | 0.688 |
PKR |
0.731 | 0.002 | 1 | 0.750 |
YSK4 |
0.731 | -0.009 | 1 | 0.791 |
DCAMKL2 |
0.730 | 0.067 | -3 | 0.853 |
BMPR1B |
0.730 | 0.024 | 1 | 0.710 |
SGK1 |
0.730 | 0.114 | -3 | 0.629 |
MLK2 |
0.730 | -0.097 | 2 | 0.794 |
ATM |
0.729 | -0.034 | 1 | 0.661 |
CAMK1G |
0.729 | 0.027 | -3 | 0.774 |
CDK19 |
0.729 | -0.030 | 1 | 0.578 |
BRAF |
0.728 | 0.065 | -4 | 0.790 |
PAK4 |
0.728 | 0.071 | -2 | 0.645 |
MRCKB |
0.728 | 0.153 | -3 | 0.774 |
P38A |
0.728 | 0.014 | 1 | 0.635 |
JNK3 |
0.727 | 0.009 | 1 | 0.593 |
PKCZ |
0.727 | -0.015 | 2 | 0.766 |
CDK5 |
0.727 | -0.010 | 1 | 0.608 |
MAPKAPK5 |
0.727 | -0.043 | -3 | 0.698 |
MEK1 |
0.726 | -0.062 | 2 | 0.812 |
ALK2 |
0.726 | 0.033 | -2 | 0.756 |
CDK18 |
0.726 | 0.009 | 1 | 0.535 |
ACVR2A |
0.726 | 0.008 | -2 | 0.777 |
ROCK2 |
0.725 | 0.169 | -3 | 0.819 |
PKCT |
0.725 | 0.042 | 2 | 0.714 |
IRAK4 |
0.725 | 0.022 | 1 | 0.716 |
DRAK1 |
0.725 | 0.023 | 1 | 0.673 |
VRK2 |
0.724 | -0.110 | 1 | 0.789 |
AKT3 |
0.724 | 0.081 | -3 | 0.643 |
SMMLCK |
0.724 | 0.029 | -3 | 0.814 |
CK2A1 |
0.724 | 0.224 | 1 | 0.578 |
CDK16 |
0.724 | 0.063 | 1 | 0.503 |
MST3 |
0.723 | 0.092 | 2 | 0.787 |
CHAK1 |
0.723 | -0.060 | 2 | 0.742 |
HIPK1 |
0.723 | 0.015 | 1 | 0.634 |
DYRK1B |
0.723 | 0.026 | 1 | 0.581 |
MLK3 |
0.722 | -0.054 | 2 | 0.709 |
P38G |
0.722 | 0.013 | 1 | 0.493 |
ACVR2B |
0.722 | -0.020 | -2 | 0.786 |
CDK9 |
0.722 | -0.024 | 1 | 0.596 |
CDK10 |
0.721 | 0.053 | 1 | 0.567 |
P38B |
0.721 | 0.001 | 1 | 0.579 |
DYRK1A |
0.721 | 0.002 | 1 | 0.654 |
TLK2 |
0.721 | -0.030 | 1 | 0.728 |
CDK2 |
0.721 | -0.037 | 1 | 0.632 |
ZAK |
0.721 | 0.002 | 1 | 0.774 |
CDK14 |
0.721 | 0.027 | 1 | 0.588 |
CDK1 |
0.720 | -0.025 | 1 | 0.556 |
PKN1 |
0.720 | 0.027 | -3 | 0.748 |
DAPK3 |
0.720 | 0.068 | -3 | 0.819 |
SMG1 |
0.719 | -0.059 | 1 | 0.668 |
MLK4 |
0.719 | -0.071 | 2 | 0.706 |
PKCI |
0.719 | 0.042 | 2 | 0.723 |
CDK17 |
0.719 | -0.001 | 1 | 0.491 |
ERK1 |
0.719 | -0.015 | 1 | 0.576 |
ERK2 |
0.719 | -0.014 | 1 | 0.598 |
HIPK2 |
0.719 | 0.003 | 1 | 0.534 |
HRI |
0.719 | -0.066 | -2 | 0.851 |
DMPK1 |
0.719 | 0.169 | -3 | 0.808 |
CDK13 |
0.719 | -0.045 | 1 | 0.582 |
MEKK3 |
0.718 | -0.046 | 1 | 0.784 |
TTBK1 |
0.718 | -0.008 | 2 | 0.649 |
MEKK1 |
0.718 | -0.081 | 1 | 0.790 |
CAMK1A |
0.718 | 0.017 | -3 | 0.693 |
PASK |
0.717 | 0.024 | -3 | 0.820 |
TAO3 |
0.717 | 0.032 | 1 | 0.774 |
PERK |
0.717 | -0.065 | -2 | 0.819 |
CDK3 |
0.716 | -0.015 | 1 | 0.506 |
PKCE |
0.716 | 0.047 | 2 | 0.689 |
NEK5 |
0.716 | -0.049 | 1 | 0.757 |
TLK1 |
0.716 | -0.022 | -2 | 0.790 |
PRP4 |
0.716 | -0.009 | -3 | 0.736 |
HIPK3 |
0.716 | -0.013 | 1 | 0.657 |
DYRK3 |
0.715 | 0.004 | 1 | 0.638 |
MEKK2 |
0.715 | -0.050 | 2 | 0.791 |
MEK5 |
0.715 | -0.091 | 2 | 0.803 |
PKG1 |
0.715 | 0.058 | -2 | 0.637 |
BMPR1A |
0.715 | 0.007 | 1 | 0.698 |
DAPK1 |
0.714 | 0.060 | -3 | 0.793 |
DYRK4 |
0.714 | -0.004 | 1 | 0.556 |
IRAK1 |
0.714 | -0.074 | -1 | 0.760 |
ROCK1 |
0.713 | 0.139 | -3 | 0.794 |
TAO2 |
0.713 | 0.042 | 2 | 0.826 |
CDK12 |
0.713 | -0.040 | 1 | 0.564 |
CHK2 |
0.713 | 0.003 | -3 | 0.678 |
SBK |
0.712 | 0.021 | -3 | 0.603 |
LOK |
0.712 | 0.099 | -2 | 0.781 |
GCK |
0.711 | 0.057 | 1 | 0.820 |
NEK4 |
0.710 | 0.016 | 1 | 0.787 |
HPK1 |
0.710 | 0.096 | 1 | 0.829 |
CK1G1 |
0.710 | -0.002 | -3 | 0.509 |
P38D |
0.710 | -0.000 | 1 | 0.505 |
GAK |
0.710 | 0.025 | 1 | 0.760 |
KHS1 |
0.710 | 0.100 | 1 | 0.833 |
CRIK |
0.710 | 0.076 | -3 | 0.721 |
CK1E |
0.710 | -0.016 | -3 | 0.524 |
GRK2 |
0.709 | -0.055 | -2 | 0.633 |
LKB1 |
0.708 | 0.022 | -3 | 0.804 |
KHS2 |
0.708 | 0.103 | 1 | 0.836 |
NEK11 |
0.707 | -0.071 | 1 | 0.789 |
PDK1 |
0.707 | -0.045 | 1 | 0.754 |
HGK |
0.707 | 0.015 | 3 | 0.507 |
CAMKK1 |
0.706 | -0.034 | -2 | 0.751 |
MINK |
0.706 | 0.018 | 1 | 0.824 |
TNIK |
0.706 | 0.036 | 3 | 0.503 |
CAMKK2 |
0.705 | -0.034 | -2 | 0.750 |
PLK2 |
0.705 | 0.016 | -3 | 0.735 |
CDK4 |
0.705 | -0.001 | 1 | 0.549 |
NEK8 |
0.705 | -0.080 | 2 | 0.802 |
EEF2K |
0.704 | -0.013 | 3 | 0.516 |
GSK3A |
0.704 | 0.011 | 4 | 0.433 |
MPSK1 |
0.704 | -0.041 | 1 | 0.685 |
MST2 |
0.704 | -0.032 | 1 | 0.824 |
CDK6 |
0.704 | -0.003 | 1 | 0.571 |
JNK1 |
0.704 | -0.009 | 1 | 0.548 |
NEK1 |
0.703 | 0.006 | 1 | 0.753 |
GSK3B |
0.703 | -0.021 | 4 | 0.425 |
MEKK6 |
0.703 | -0.014 | 1 | 0.767 |
MST1 |
0.702 | 0.027 | 1 | 0.813 |
RIPK2 |
0.702 | -0.084 | 1 | 0.753 |
ERK7 |
0.701 | 0.002 | 2 | 0.537 |
MAP3K15 |
0.701 | -0.041 | 1 | 0.762 |
PINK1 |
0.700 | -0.167 | 1 | 0.699 |
MOK |
0.700 | 0.023 | 1 | 0.622 |
CK1A2 |
0.700 | -0.020 | -3 | 0.480 |
YSK1 |
0.700 | 0.036 | 2 | 0.780 |
SLK |
0.700 | 0.027 | -2 | 0.701 |
BUB1 |
0.700 | -0.041 | -5 | 0.162 |
PBK |
0.699 | 0.032 | 1 | 0.706 |
MAK |
0.699 | 0.012 | -2 | 0.727 |
LRRK2 |
0.697 | -0.055 | 2 | 0.830 |
TAK1 |
0.697 | -0.038 | 1 | 0.792 |
GRK3 |
0.696 | -0.045 | -2 | 0.573 |
CK1D |
0.696 | -0.039 | -3 | 0.477 |
STK33 |
0.695 | -0.036 | 2 | 0.614 |
VRK1 |
0.695 | -0.111 | 2 | 0.840 |
PDHK3_TYR |
0.694 | 0.150 | 4 | 0.898 |
MEK2 |
0.694 | -0.081 | 2 | 0.791 |
NEK3 |
0.692 | -0.054 | 1 | 0.749 |
TTK |
0.688 | -0.013 | -2 | 0.811 |
HASPIN |
0.686 | -0.005 | -1 | 0.702 |
TESK1_TYR |
0.686 | 0.078 | 3 | 0.579 |
TAO1 |
0.686 | 0.014 | 1 | 0.745 |
BIKE |
0.684 | -0.013 | 1 | 0.665 |
RET |
0.683 | 0.061 | 1 | 0.767 |
MAP2K7_TYR |
0.683 | 0.059 | 2 | 0.841 |
LIMK2_TYR |
0.683 | 0.076 | -3 | 0.875 |
PDHK4_TYR |
0.682 | 0.034 | 2 | 0.854 |
ASK1 |
0.681 | -0.030 | 1 | 0.752 |
PKMYT1_TYR |
0.681 | -0.025 | 3 | 0.552 |
MAP2K4_TYR |
0.680 | -0.053 | -1 | 0.866 |
OSR1 |
0.679 | -0.070 | 2 | 0.768 |
MAP2K6_TYR |
0.678 | -0.032 | -1 | 0.876 |
EPHA6 |
0.678 | 0.014 | -1 | 0.870 |
DDR1 |
0.677 | 0.025 | 4 | 0.821 |
BMPR2_TYR |
0.677 | -0.023 | -1 | 0.867 |
MYO3B |
0.676 | -0.043 | 2 | 0.790 |
TYK2 |
0.676 | -0.038 | 1 | 0.781 |
ROS1 |
0.676 | -0.037 | 3 | 0.472 |
PDHK1_TYR |
0.676 | -0.022 | -1 | 0.885 |
PINK1_TYR |
0.676 | -0.047 | 1 | 0.743 |
EPHB4 |
0.676 | -0.031 | -1 | 0.852 |
MYO3A |
0.675 | -0.034 | 1 | 0.772 |
TYRO3 |
0.675 | -0.050 | 3 | 0.491 |
MST1R |
0.673 | -0.052 | 3 | 0.491 |
JAK2 |
0.672 | -0.073 | 1 | 0.783 |
INSRR |
0.672 | -0.010 | 3 | 0.476 |
ALPHAK3 |
0.671 | -0.047 | -1 | 0.771 |
LIMK1_TYR |
0.671 | -0.060 | 2 | 0.840 |
YES1 |
0.671 | -0.022 | -1 | 0.820 |
YANK3 |
0.671 | -0.042 | 2 | 0.420 |
AAK1 |
0.670 | -0.003 | 1 | 0.574 |
STLK3 |
0.670 | -0.049 | 1 | 0.756 |
TNK1 |
0.670 | 0.014 | 3 | 0.487 |
CSF1R |
0.670 | -0.077 | 3 | 0.480 |
TNNI3K_TYR |
0.669 | 0.016 | 1 | 0.777 |
EPHB1 |
0.669 | -0.041 | 1 | 0.795 |
NEK10_TYR |
0.668 | 0.027 | 1 | 0.671 |
DDR2 |
0.668 | 0.035 | 3 | 0.457 |
FGFR2 |
0.667 | -0.018 | 3 | 0.508 |
ITK |
0.667 | -0.055 | -1 | 0.791 |
EPHB3 |
0.667 | -0.047 | -1 | 0.837 |
TNK2 |
0.666 | -0.055 | 3 | 0.447 |
JAK3 |
0.666 | -0.058 | 1 | 0.732 |
ABL2 |
0.666 | -0.072 | -1 | 0.793 |
KDR |
0.666 | -0.013 | 3 | 0.462 |
TXK |
0.666 | -0.037 | 1 | 0.746 |
EPHB2 |
0.666 | -0.039 | -1 | 0.831 |
AXL |
0.666 | -0.043 | 3 | 0.484 |
TEK |
0.665 | -0.040 | 3 | 0.460 |
PDGFRB |
0.665 | -0.074 | 3 | 0.491 |
FGR |
0.665 | -0.087 | 1 | 0.772 |
FGFR1 |
0.665 | -0.047 | 3 | 0.491 |
EPHA4 |
0.664 | -0.039 | 2 | 0.766 |
FER |
0.664 | -0.113 | 1 | 0.784 |
HCK |
0.663 | -0.085 | -1 | 0.811 |
JAK1 |
0.663 | -0.036 | 1 | 0.770 |
FLT3 |
0.662 | -0.077 | 3 | 0.481 |
ABL1 |
0.662 | -0.073 | -1 | 0.782 |
ALK |
0.662 | -0.048 | 3 | 0.453 |
SRMS |
0.662 | -0.081 | 1 | 0.781 |
MERTK |
0.661 | -0.058 | 3 | 0.493 |
LTK |
0.661 | -0.038 | 3 | 0.471 |
EPHA1 |
0.660 | -0.044 | 3 | 0.457 |
EPHA7 |
0.659 | -0.046 | 2 | 0.780 |
CK1A |
0.659 | -0.060 | -3 | 0.389 |
LCK |
0.659 | -0.082 | -1 | 0.811 |
KIT |
0.658 | -0.099 | 3 | 0.487 |
BLK |
0.657 | -0.066 | -1 | 0.818 |
PDGFRA |
0.657 | -0.103 | 3 | 0.482 |
TEC |
0.656 | -0.058 | -1 | 0.724 |
INSR |
0.655 | -0.068 | 3 | 0.451 |
BMX |
0.655 | -0.064 | -1 | 0.705 |
FGFR3 |
0.655 | -0.050 | 3 | 0.488 |
EPHA3 |
0.654 | -0.061 | 2 | 0.749 |
BTK |
0.654 | -0.116 | -1 | 0.755 |
MET |
0.654 | -0.085 | 3 | 0.475 |
FLT4 |
0.654 | -0.072 | 3 | 0.477 |
NTRK2 |
0.653 | -0.093 | 3 | 0.468 |
FYN |
0.653 | -0.050 | -1 | 0.781 |
NTRK1 |
0.653 | -0.125 | -1 | 0.812 |
FLT1 |
0.652 | -0.061 | -1 | 0.846 |
FRK |
0.651 | -0.087 | -1 | 0.831 |
ERBB2 |
0.650 | -0.089 | 1 | 0.734 |
EPHA5 |
0.650 | -0.060 | 2 | 0.761 |
PTK2B |
0.649 | -0.057 | -1 | 0.755 |
PTK6 |
0.649 | -0.100 | -1 | 0.712 |
CK1G3 |
0.649 | -0.041 | -3 | 0.343 |
LYN |
0.648 | -0.100 | 3 | 0.454 |
WEE1_TYR |
0.646 | -0.088 | -1 | 0.733 |
EPHA8 |
0.644 | -0.084 | -1 | 0.810 |
NTRK3 |
0.643 | -0.129 | -1 | 0.762 |
EGFR |
0.643 | -0.054 | 1 | 0.647 |
CSK |
0.643 | -0.101 | 2 | 0.783 |
SRC |
0.642 | -0.098 | -1 | 0.773 |
IGF1R |
0.641 | -0.080 | 3 | 0.430 |
YANK2 |
0.638 | -0.050 | 2 | 0.435 |
FGFR4 |
0.637 | -0.082 | -1 | 0.763 |
MATK |
0.636 | -0.106 | -1 | 0.716 |
PTK2 |
0.636 | -0.044 | -1 | 0.809 |
EPHA2 |
0.636 | -0.080 | -1 | 0.786 |
MUSK |
0.632 | -0.107 | 1 | 0.630 |
ERBB4 |
0.632 | -0.064 | 1 | 0.659 |
SYK |
0.630 | -0.069 | -1 | 0.783 |
CK1G2 |
0.624 | -0.078 | -3 | 0.433 |
FES |
0.619 | -0.121 | -1 | 0.676 |
ZAP70 |
0.604 | -0.098 | -1 | 0.691 |