Motif 812 (n=119)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NMY6 | ANXA2P2 | S161 | ochoa | Putative annexin A2-like protein (Annexin A2 pseudogene 2) (Lipocortin II pseudogene) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. {ECO:0000250}. |
| E9PLD3 | None | S65 | ochoa | Uncharacterized protein | None |
| E9PRG8 | C11orf98 | S65 | ochoa | Uncharacterized protein C11orf98 | None |
| H7C0S8 | None | S222 | ochoa | Argininosuccinate lyase (Calcitonin gene-related peptide-receptor component protein) (DNA-directed RNA polymerase III subunit RPC9) | Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues. {ECO:0000256|ARBA:ARBA00043924}.; FUNCTION: Catalyzes the reversible cleavage of L-argininosuccinate to fumarate and L-arginine, an intermediate step reaction in the urea cycle mostly providing for hepatic nitrogen detoxification into excretable urea as well as de novo L-arginine synthesis in nonhepatic tissues. Essential regulator of intracellular and extracellular L-arginine pools. As part of citrulline-nitric oxide cycle, forms tissue-specific multiprotein complexes with argininosuccinate synthase ASS1, transport protein SLC7A1 and nitric oxide synthase NOS1, NOS2 or NOS3, allowing for cell-autonomous L-arginine synthesis while channeling extracellular L-arginine to nitric oxide synthesis pathway. {ECO:0000256|ARBA:ARBA00045522}.; FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. With POLR3H/RPC8 forms a mobile stalk that protrudes from Pol III core and functions primarily in transcription initiation. Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway. {ECO:0000256|ARBA:ARBA00045808}. |
| O15400 | STX7 | S129 | ochoa | Syntaxin-7 | May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes. |
| O43683 | BUB1 | S437 | ochoa | Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) | Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (PubMed:35044816). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:17158872, ECO:0000269|PubMed:19487456, ECO:0000269|PubMed:20739936, ECO:0000269|PubMed:35044816}. |
| O60268 | KIAA0513 | S279 | ochoa | Uncharacterized protein KIAA0513 | None |
| O75575 | CRCP | S37 | ochoa | DNA-directed RNA polymerase III subunit RPC9 (RNA polymerase III subunit C9) (Calcitonin gene-related peptide-receptor component protein) (CGRP-RCP) (CGRP-receptor component protein) (CGRPRCP) (HsC17) | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:20413673, PubMed:33558764, PubMed:34675218). Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. With POLR3H/RPC8 forms a mobile stalk that protrudes from Pol III core and functions primarily in transcription initiation (By similarity) (PubMed:20413673, PubMed:33558764, PubMed:33558766, PubMed:34675218). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway (PubMed:19609254, PubMed:19631370). {ECO:0000250|UniProtKB:Q9C0Z9, ECO:0000269|PubMed:19609254, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20413673, ECO:0000269|PubMed:33558764, ECO:0000269|PubMed:33558766, ECO:0000269|PubMed:34675218}.; FUNCTION: Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues. {ECO:0000250|UniProtKB:O35427}. |
| O94763 | URI1 | S375 | ochoa | Unconventional prefoldin RPB5 interactor 1 (Protein NNX3) (Protein phosphatase 1 regulatory subunit 19) (RNA polymerase II subunit 5-mediating protein) (RPB5-mediating protein) | Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein.; FUNCTION: Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination. |
| O94953 | KDM4B | S1041 | ochoa | Lysine-specific demethylase 4B (EC 1.14.11.66) (JmjC domain-containing histone demethylation protein 3B) (Jumonji domain-containing protein 2B) ([histone H3]-trimethyl-L-lysine(9) demethylase 4B) | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate (PubMed:16603238, PubMed:28262558). Plays a critical role in the development of the central nervous system (CNS). {ECO:0000250|UniProtKB:Q91VY5, ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:28262558}. |
| O96028 | NSD2 | S407 | ochoa | Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein) | Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:19808676, PubMed:22099308, PubMed:27571355, PubMed:29728617, PubMed:33941880). Also monomethylates nucleosomal histone H3 at 'Lys-36' (H3K36me) in vitro (PubMed:22099308). Does not trimethylate nucleosomal histone H3 at 'Lys-36' (H3K36me3) (PubMed:22099308). However, specifically trimethylates histone H3 at 'Lys-36' (H3K36me3) at euchromatic regions in embryonic stem (ES) cells (By similarity). By methylating histone H3 at 'Lys-36', involved in the regulation of gene transcription during various biological processes (PubMed:16115125, PubMed:22099308, PubMed:29728617). In ES cells, associates with developmental transcription factors such as SALL1 and represses inappropriate gene transcription mediated by histone deacetylation (By similarity). During heart development, associates with transcription factor NKX2-5 to repress transcription of NKX2-5 target genes (By similarity). Plays an essential role in adipogenesis, by regulating expression of genes involved in pre-adipocyte differentiation (PubMed:29728617). During T-cell receptor (TCR) and CD28-mediated T-cell activation, promotes the transcription of transcription factor BCL6 which is required for follicular helper T (Tfh) cell differentiation (By similarity). During B-cell development, required for the generation of the B1 lineage (By similarity). During B2 cell activation, may contribute to the control of isotype class switch recombination (CRS), splenic germinal center formation, and the humoral immune response (By similarity). Plays a role in class switch recombination of the immunoglobulin heavy chain (IgH) locus during B-cell activation (By similarity). By regulating the methylation of histone H3 at 'Lys-36' and histone H4 at 'Lys-20' at the IgH locus, involved in TP53BP1 recruitment to the IgH switch region and promotes the transcription of IgA (By similarity). {ECO:0000250|UniProtKB:Q8BVE8, ECO:0000269|PubMed:16115125, ECO:0000269|PubMed:19808676, ECO:0000269|PubMed:22099308, ECO:0000269|PubMed:27571355, ECO:0000269|PubMed:29728617, ECO:0000269|PubMed:33941880}.; FUNCTION: [Isoform 1]: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2). {ECO:0000269|PubMed:22099308}.; FUNCTION: [Isoform 4]: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:22099308). Methylation of histone H3 at 'Lys-27' is controversial (PubMed:18172012, PubMed:22099308). Mono-, di- or tri-methylates histone H3 at 'Lys-27' (H3K27me, H3K27me2 and H3K27me3) (PubMed:18172012). Does not methylate histone H3 at 'Lys-27' (PubMed:22099308). May act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment (PubMed:11152655, PubMed:18172012). {ECO:0000269|PubMed:11152655, ECO:0000269|PubMed:18172012, ECO:0000269|PubMed:22099308}. |
| P00338 | LDHA | S237 | ochoa | L-lactate dehydrogenase A chain (LDH-A) (EC 1.1.1.27) (Cell proliferation-inducing gene 19 protein) (LDH muscle subunit) (LDH-M) (Renal carcinoma antigen NY-REN-59) | Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). {ECO:0000269|PubMed:11276087}. |
| P02795 | MT2A | S35 | ochoa | Metallothionein-2 (MT-2) (Metallothionein-2A) (Metallothionein-II) (MT-II) | Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. |
| P04049 | RAF1 | S322 | ochoa | RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) | Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}. |
| P04083 | ANXA1 | S170 | ochoa | Annexin A1 (Annexin I) (Annexin-1) (Calpactin II) (Calpactin-2) (Chromobindin-9) (Lipocortin I) (Phospholipase A2 inhibitory protein) (p35) [Cleaved into: Annexin Ac2-26] | Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity). {ECO:0000250|UniProtKB:P10107, ECO:0000250|UniProtKB:P19619, ECO:0000269|PubMed:17008549, ECO:0000269|PubMed:19625660, ECO:0000269|PubMed:2532504, ECO:0000269|PubMed:2936963, ECO:0000269|PubMed:8425544, ECO:0000269|PubMed:8557678}.; FUNCTION: [Annexin Ac2-26]: Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:15187149, PubMed:22879591, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Promotes resolution of inflammation and wound healing (PubMed:25664854). Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2 (PubMed:22879591). {ECO:0000269|PubMed:15187149, ECO:0000269|PubMed:22879591, ECO:0000269|PubMed:25664854}. |
| P04350 | TUBB4A | S234 | ochoa | Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P04732 | MT1E | S35 | ochoa | Metallothionein-1E (MT-1E) (Metallothionein-IE) (MT-IE) | Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. |
| P06400 | RB1 | S758 | psp | Retinoblastoma-associated protein (p105-Rb) (p110-RB1) (pRb) (Rb) (pp110) | Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle (PubMed:10499802). The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes (PubMed:10499802). Both physically blocks E2Fs transactivating domain and recruits chromatin-modifying enzymes that actively repress transcription (PubMed:10499802). Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase (PubMed:10499802). RB1 also promotes the G0-G1 transition upon phosphorylation and activation by CDK3/cyclin-C (PubMed:15084261). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). {ECO:0000250|UniProtKB:P13405, ECO:0000250|UniProtKB:P33568, ECO:0000269|PubMed:10499802, ECO:0000269|PubMed:15084261}.; FUNCTION: (Microbial infection) In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity. {ECO:0000269|PubMed:1316611, ECO:0000269|PubMed:17974914, ECO:0000269|PubMed:18701596, ECO:0000269|PubMed:2839300, ECO:0000269|PubMed:8892909}. |
| P07355 | ANXA2 | S161 | ochoa | Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:22848640, PubMed:24808179). Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation (By similarity). Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis (By similarity). {ECO:0000250|UniProtKB:P07356, ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22848640, ECO:0000269|PubMed:24808179}.; FUNCTION: (Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen. {ECO:0000269|PubMed:25139904}. |
| P07437 | TUBB | S234 | ochoa | Tubulin beta chain (Tubulin beta-5 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P08047 | SP1 | S702 | psp | Transcription factor Sp1 | Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Also binds the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component BMAL1 (PubMed:10391891, PubMed:11371615, PubMed:11904305, PubMed:14593115, PubMed:16377629, PubMed:16478997, PubMed:16943418, PubMed:17049555, PubMed:18171990, PubMed:18199680, PubMed:18239466, PubMed:18513490, PubMed:18619531, PubMed:19193796, PubMed:20091743, PubMed:21046154, PubMed:21798247). Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays a role in protecting cells against oxidative stress following brain injury by regulating the expression of RNF112 (By similarity). {ECO:0000250|UniProtKB:O89090, ECO:0000250|UniProtKB:Q01714, ECO:0000269|PubMed:10391891, ECO:0000269|PubMed:11371615, ECO:0000269|PubMed:11904305, ECO:0000269|PubMed:14593115, ECO:0000269|PubMed:16377629, ECO:0000269|PubMed:16478997, ECO:0000269|PubMed:16943418, ECO:0000269|PubMed:17049555, ECO:0000269|PubMed:18171990, ECO:0000269|PubMed:18199680, ECO:0000269|PubMed:18239466, ECO:0000269|PubMed:18513490, ECO:0000269|PubMed:18619531, ECO:0000269|PubMed:19193796, ECO:0000269|PubMed:20091743, ECO:0000269|PubMed:21046154, ECO:0000269|PubMed:21798247}. |
| P13640 | MT1G | S36 | ochoa | Metallothionein-1G (MT-1G) (Metallothionein-1K) (MT-1K) (Metallothionein-IG) (MT-IG) | Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. |
| P15311 | EZR | S144 | ochoa | Ezrin (Cytovillin) (Villin-2) (p81) | Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis. {ECO:0000269|PubMed:17881735, ECO:0000269|PubMed:18270268, ECO:0000269|PubMed:19111582}. |
| P19525 | EIF2AK2 | S33 | ochoa | Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2A protein kinase 2) (Interferon-inducible RNA-dependent protein kinase) (P1/eIF-2A protein kinase) (Protein kinase RNA-activated) (PKR) (Protein kinase R) (Tyrosine-protein kinase EIF2AK2) (EC 2.7.10.2) (p68 kinase) | IFN-induced dsRNA-dependent serine/threonine-protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) and plays a key role in the innate immune response to viral infection (PubMed:18835251, PubMed:19189853, PubMed:19507191, PubMed:21072047, PubMed:21123651, PubMed:22381929, PubMed:22948139, PubMed:23229543). Inhibits viral replication via the integrated stress response (ISR): EIF2S1/eIF-2-alpha phosphorylation in response to viral infection converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, resulting to a shutdown of cellular and viral protein synthesis, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4 (PubMed:19189853, PubMed:21123651, PubMed:22948139, PubMed:23229543). Exerts its antiviral activity on a wide range of DNA and RNA viruses including hepatitis C virus (HCV), hepatitis B virus (HBV), measles virus (MV) and herpes simplex virus 1 (HHV-1) (PubMed:11836380, PubMed:19189853, PubMed:19840259, PubMed:20171114, PubMed:21710204, PubMed:23115276, PubMed:23399035). Also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation: phosphorylates other substrates including p53/TP53, PPP2R5A, DHX9, ILF3, IRS1 and the HHV-1 viral protein US11 (PubMed:11836380, PubMed:19229320, PubMed:22214662). In addition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity and phosphorylates CDK1 at 'Tyr-4' upon DNA damage, facilitating its ubiquitination and proteasomal degradation (PubMed:20395957). Either as an adapter protein and/or via its kinase activity, can regulate various signaling pathways (p38 MAP kinase, NF-kappa-B and insulin signaling pathways) and transcription factors (JUN, STAT1, STAT3, IRF1, ATF3) involved in the expression of genes encoding pro-inflammatory cytokines and IFNs (PubMed:22948139, PubMed:23084476, PubMed:23372823). Activates the NF-kappa-B pathway via interaction with IKBKB and TRAF family of proteins and activates the p38 MAP kinase pathway via interaction with MAP2K6 (PubMed:10848580, PubMed:15121867, PubMed:15229216). Can act as both a positive and negative regulator of the insulin signaling pathway (ISP) (PubMed:20685959). Negatively regulates ISP by inducing the inhibitory phosphorylation of insulin receptor substrate 1 (IRS1) at 'Ser-312' and positively regulates ISP via phosphorylation of PPP2R5A which activates FOXO1, which in turn up-regulates the expression of insulin receptor substrate 2 (IRS2) (PubMed:20685959). Can regulate NLRP3 inflammasome assembly and the activation of NLRP3, NLRP1, AIM2 and NLRC4 inflammasomes (PubMed:22801494). Plays a role in the regulation of the cytoskeleton by binding to gelsolin (GSN), sequestering the protein in an inactive conformation away from actin (By similarity). {ECO:0000250|UniProtKB:Q03963, ECO:0000269|PubMed:10848580, ECO:0000269|PubMed:11836380, ECO:0000269|PubMed:15121867, ECO:0000269|PubMed:15229216, ECO:0000269|PubMed:18835251, ECO:0000269|PubMed:19189853, ECO:0000269|PubMed:19229320, ECO:0000269|PubMed:19507191, ECO:0000269|PubMed:19840259, ECO:0000269|PubMed:20171114, ECO:0000269|PubMed:20395957, ECO:0000269|PubMed:20685959, ECO:0000269|PubMed:21072047, ECO:0000269|PubMed:21123651, ECO:0000269|PubMed:21710204, ECO:0000269|PubMed:22214662, ECO:0000269|PubMed:22381929, ECO:0000269|PubMed:22801494, ECO:0000269|PubMed:22948139, ECO:0000269|PubMed:23084476, ECO:0000269|PubMed:23115276, ECO:0000269|PubMed:23229543, ECO:0000269|PubMed:23372823, ECO:0000269|PubMed:23399035, ECO:0000269|PubMed:32197074}. |
| P23508 | MCC | S684 | ochoa | Colorectal mutant cancer protein (Protein MCC) | Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation (PubMed:18591935, PubMed:19555689, PubMed:22480440). Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity (PubMed:24824780). {ECO:0000269|PubMed:18591935, ECO:0000269|PubMed:19555689, ECO:0000269|PubMed:22480440, ECO:0000269|PubMed:24824780}. |
| P25054 | APC | S1906 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P25787 | PSMA2 | S77 | ochoa | Proteasome subunit alpha type-2 (Macropain subunit C3) (Multicatalytic endopeptidase complex subunit C3) (Proteasome component C3) (Proteasome subunit alpha-2) (alpha-2) | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. |
| P30414 | NKTR | S379 | ochoa | NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Component of a putative tumor-recognition complex involved in the function of NK cells (PubMed:8421688). {ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:8421688}. |
| P30566 | ADSL | S289 | ochoa | Adenylosuccinate lyase (ADSL) (ASL) (EC 4.3.2.2) (Adenylosuccinase) (ASase) | Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate. {ECO:0000269|PubMed:10888601}. |
| P38398 | BRCA1 | S510 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P42285 | MTREX | S40 | ochoa | Exosome RNA helicase MTR4 (EC 3.6.4.13) (ATP-dependent RNA helicase DOB1) (ATP-dependent RNA helicase SKIV2L2) (Superkiller viralicidic activity 2-like 2) (TRAMP-like complex helicase) | Catalyzes the ATP-dependent unwinding of RNA duplexes with a single-stranded 3' RNA extension (PubMed:27871484, PubMed:29844170, PubMed:29906447). Central subunit of many protein complexes, namely TRAMP-like, nuclear exosome targeting (NEXT) and poly(A) tail exosome targeting (PAXT) (PubMed:21855801, PubMed:27871484, PubMed:29844170). NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. NEXT is involved in surveillance and turnover of aberrant transcripts and non-coding RNAs (PubMed:27871484, PubMed:29844170). PAXT directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor ZCCHC8, which links to RNA-binding protein adapters (PubMed:27871484). Associated with the RNA exosome complex and involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA (PubMed:17412707, PubMed:29107693). May be involved in pre-mRNA splicing. In the context of NEXT complex can also in vitro unwind DNA:RNA heteroduplexes with a 3' poly (A) RNA tracking strand (PubMed:29844170). Can promote unwinding and degradation of structured RNA substrates when associated with the nuclear exosome and its cofactors. Can displace a DNA strand while translocating on RNA to ultimately degrade the RNA within a DNA/RNA heteroduplex (PubMed:29906447). Plays a role in DNA damage response (PubMed:29902117). {ECO:0000269|PubMed:17412707, ECO:0000269|PubMed:21855801, ECO:0000269|PubMed:27871484, ECO:0000269|PubMed:29107693, ECO:0000269|PubMed:29844170, ECO:0000269|PubMed:29902117, ECO:0000269|PubMed:29906447}. |
| P42677 | RPS27 | S27 | ochoa|psp | Small ribosomal subunit protein eS27 (40S ribosomal protein S27) (Metallopan-stimulin 1) (MPS-1) | Component of the small ribosomal subunit (PubMed:23636399, PubMed:8706699). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Required for proper rRNA processing and maturation of 18S rRNAs (PubMed:25424902). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25424902, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:8706699}. |
| P46013 | MKI67 | S1048 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S1414 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S1656 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S2505 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S2626 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S2746 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | S2865 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P48382 | RFX5 | S476 | ochoa | DNA-binding protein RFX5 (Regulatory factor X 5) | Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters. |
| P51532 | SMARCA4 | S1421 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 (SMARCA4) (EC 3.6.4.-) (BRG1-associated factor 190A) (BAF190A) (Mitotic growth and transcription activator) (Protein BRG-1) (Protein brahma homolog 1) (SNF2-beta) (Transcription activator BRG1) | ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:15075294, PubMed:29374058, PubMed:30339381, PubMed:32459350). Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor complex and the recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by SMARCA4-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves the release of HDAC1 and recruitment of CREBBP (By similarity). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development, a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues (By similarity). Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1 (PubMed:20418909). Binds via DLX1 to enhancers located in the intergenic region between DLX5 and DLX6 and this binding is stabilized by the long non-coding RNA (lncRNA) Evf2 (By similarity). Binds to RNA in a promiscuous manner (By similarity). In brown adipose tissue, involved in the regulation of thermogenic genes expression (By similarity). {ECO:0000250|UniProtKB:Q3TKT4, ECO:0000250|UniProtKB:Q8K1P7, ECO:0000269|PubMed:15075294, ECO:0000269|PubMed:19571879, ECO:0000269|PubMed:20418909, ECO:0000269|PubMed:29374058, ECO:0000269|PubMed:30339381, ECO:0000269|PubMed:32459350, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| P54578 | USP14 | S143 | ochoa|psp | Ubiquitin carboxyl-terminal hydrolase 14 (EC 3.4.19.12) (Deubiquitinating enzyme 14) (Ubiquitin thioesterase 14) (Ubiquitin-specific-processing protease 14) | Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins (PubMed:35145029). Ensures the regeneration of ubiquitin at the proteasome (PubMed:18162577, PubMed:28396413). Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell (PubMed:18162577). Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (PubMed:19106094). Also serves as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1 (PubMed:19135427). Indispensable for synaptic development and function at neuromuscular junctions (NMJs) (By similarity). Plays a role in the innate immune defense against viruses by stabilizing the viral DNA sensor CGAS and thus inhibiting its autophagic degradation (PubMed:27666593). Inhibits OPTN-mediated selective autophagic degradation of KDM4D and thereby negatively regulates H3K9me2 and H3K9me3 (PubMed:35145029). {ECO:0000250|UniProtKB:Q9JMA1, ECO:0000269|PubMed:18162577, ECO:0000269|PubMed:19106094, ECO:0000269|PubMed:19135427, ECO:0000269|PubMed:27666593, ECO:0000269|PubMed:28396413, ECO:0000269|PubMed:35145029}. |
| P55198 | MLLT6 | S258 | ochoa | Protein AF-17 (ALL1-fused gene from chromosome 17 protein) | None |
| P61964 | WDR5 | S20 | ochoa | WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein) | Contributes to histone modification (PubMed:16600877, PubMed:16829960, PubMed:19103755, PubMed:19131338, PubMed:19556245, PubMed:20018852). May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4' (PubMed:16829960). As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:18840606). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:19103755, PubMed:20018852). May regulate osteoblasts differentiation (By similarity). In association with RBBP5 and ASH2L, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653). {ECO:0000250|UniProtKB:P61965, ECO:0000269|PubMed:16600877, ECO:0000269|PubMed:16829960, ECO:0000269|PubMed:18840606, ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:22266653}. |
| P63151 | PPP2R2A | S409 | ochoa | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (PP2A subunit B isoform B55-alpha) (B55) (PP2A subunit B isoform PR55-alpha) (PP2A subunit B isoform R2-alpha) (PP2A subunit B isoform alpha) | Substrate-recognition subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit (PubMed:1849734, PubMed:33108758). Involved in chromosome clustering during late mitosis by mediating dephosphorylation of MKI67 (By similarity). Essential for serine/threonine-protein phosphatase 2A-mediated dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint (PubMed:33108758). {ECO:0000250|UniProtKB:Q6P1F6, ECO:0000269|PubMed:1849734, ECO:0000269|PubMed:33108758}. |
| P68104 | EEF1A1 | S224 | ochoa | Elongation factor 1-alpha 1 (EF-1-alpha-1) (EC 3.6.5.-) (Elongation factor Tu) (EF-Tu) (Eukaryotic elongation factor 1 A-1) (eEF1A-1) (Leukocyte receptor cluster member 7) | Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623, PubMed:36638793). Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623, PubMed:36638793). The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623). Also plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1 (PubMed:17177976). Also plays a role in cytoskeleton organization by promoting actin bundling (By similarity). {ECO:0000250|UniProtKB:P68105, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:26593721, ECO:0000269|PubMed:26651998, ECO:0000269|PubMed:36123449, ECO:0000269|PubMed:36264623, ECO:0000269|PubMed:36638793}.; FUNCTION: (Microbial infection) Required for the translation of viral proteins and viral replication during human coronavirus SARS-CoV-2 infection. {ECO:0000269|PubMed:33495306}. |
| P68371 | TUBB4B | S234 | ochoa | Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P78332 | RBM6 | S613 | ochoa | RNA-binding protein 6 (Lung cancer antigen NY-LU-12) (Protein G16) (RNA-binding motif protein 6) (RNA-binding protein DEF-3) | Specifically binds poly(G) RNA homopolymers in vitro. |
| P80297 | MT1X | S35 | ochoa | Metallothionein-1X (MT-1X) (Metallothionein-IX) (MT-IX) | Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. May be involved in FAM168A anti-apoptotic signaling (PubMed:23251525). {ECO:0000269|PubMed:23251525}. |
| Q00059 | TFAM | S124 | ochoa | Transcription factor A, mitochondrial (mtTFA) (Mitochondrial transcription factor 1) (MtTF1) (Transcription factor 6) (TCF-6) (Transcription factor 6-like 2) | Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation (PubMed:29445193, PubMed:32183942). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA (PubMed:29149603). In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand (PubMed:20410300). Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase (PubMed:22037172). Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites (PubMed:22037172). Is able to unwind DNA (PubMed:22037172). Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes (PubMed:1737790). Required for maintenance of normal levels of mitochondrial DNA (PubMed:19304746, PubMed:22841477). May play a role in organizing and compacting mitochondrial DNA (PubMed:22037171). {ECO:0000269|PubMed:1737790, ECO:0000269|PubMed:19304746, ECO:0000269|PubMed:20410300, ECO:0000269|PubMed:22037171, ECO:0000269|PubMed:22037172, ECO:0000269|PubMed:22841477, ECO:0000269|PubMed:29149603, ECO:0000269|PubMed:29445193, ECO:0000269|PubMed:32183942}. |
| Q03164 | KMT2A | S941 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q05BQ5 | MBTD1 | S309 | ochoa | MBT domain-containing protein 1 | Chromatin reader component of the NuA4 histone acetyltransferase complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:27153538, PubMed:32209463). The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR) (PubMed:27153538). MBTD1 specifically recognizes and binds monomethylated and dimethylated 'Lys-20' on histone H4 (H4K20me1 and H4K20me2, respectively) (PubMed:19841675, PubMed:27153538, PubMed:32209463). In the NuA4 complex, MBTD1 promotes recruitment of the complex to H4K20me marks by competing with TP53BP1 for binding to H4K20me (PubMed:27153538). Following recruitment to H4K20me at DNA breaks, the NuA4 complex catalyzes acetylation of 'Lys-15' on histone H2A (H2AK15), blocking the ubiquitination mark required for TP53BP1 localization at DNA breaks, thereby promoting homologous recombination (HR) (PubMed:27153538). {ECO:0000269|PubMed:19841675, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:32209463}. |
| Q12893 | TMEM115 | S267 | ochoa | Transmembrane protein 115 (Placental protein 6) (Protein PL6) | May play a role in retrograde transport of proteins from the Golgi to the endoplasmic reticulum. May indirectly play a role in protein glycosylation in the Golgi. {ECO:0000269|PubMed:24806965}. |
| Q13185 | CBX3 | S97 | ochoa | Chromobox protein homolog 3 (HECH) (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein) | Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitment of NIPBL to sites of DNA damage at double-strand breaks (DSBs) (PubMed:28167679). {ECO:0000250|UniProtKB:P23198, ECO:0000269|PubMed:28167679}. |
| Q13330 | MTA1 | S675 | ochoa | Metastasis-associated protein MTA1 | Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator (PubMed:16617102, PubMed:17671180, PubMed:17922032, PubMed:21965678, PubMed:24413532). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). In the NuRD complex, regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA (PubMed:17671180). In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A (PubMed:17922032, PubMed:24413532). Acts as a transcriptional coactivator of BCAS3, and SUMO2, independent of the NuRD complex (PubMed:16617102, PubMed:17671180, PubMed:21965678). Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3 (By similarity). Regulates p53-dependent and -independent DNA repair processes following genotoxic stress (PubMed:19837670). Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair (PubMed:19837670). Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles (By similarity). Positively regulates the CLOCK-BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1 (By similarity). Regulates deacetylation of BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression (By similarity). With TFCP2L1, promotes establishment and maintenance of pluripotency in embryonic stem cells (ESCs) and inhibits endoderm differentiation (By similarity). {ECO:0000250|UniProtKB:Q8K4B0, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:17671180, ECO:0000269|PubMed:17922032, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:24413532}.; FUNCTION: [Isoform Short]: Binds to ESR1 and sequesters it in the cytoplasm and enhances its non-genomic responses. {ECO:0000269|PubMed:15077195}. |
| Q13596 | SNX1 | S280 | ochoa | Sorting nexin-1 | Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:12198132). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:19816406, PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1) and Shiginella dysenteria toxin stxB. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi (PubMed:12198132, PubMed:15498486, PubMed:17101778, PubMed:17550970, PubMed:18088323, PubMed:21040701). Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R (PubMed:16407403, PubMed:20070609). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed:20604901). Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking (PubMed:23152498). {ECO:0000269|PubMed:12198132, ECO:0000269|PubMed:15498486, ECO:0000269|PubMed:16407403, ECO:0000269|PubMed:17101778, ECO:0000269|PubMed:17550970, ECO:0000269|PubMed:18088323, ECO:0000269|PubMed:19816406, ECO:0000269|PubMed:20070609, ECO:0000269|PubMed:20604901, ECO:0000269|PubMed:21040701, ECO:0000269|PubMed:23085988, ECO:0000269|PubMed:23152498, ECO:0000303|PubMed:15498486}. |
| Q13835 | PKP1 | S191 | ochoa|psp | Plakophilin-1 (Band 6 protein) (B6P) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:23444369). Plays a role in desmosome protein expression regulation and localization to the desmosomal plaque, thereby maintaining cell sheet integrity and anchorage of desmosomes to intermediate filaments (PubMed:10852826, PubMed:23444369). Required for localization of DSG3 and YAP1 to the cell membrane in keratinocytes in response to mechanical strain, via the formation of an interaction complex composed of DSG3, YAP1, PKP1 and YWHAG (PubMed:31835537). Positively regulates differentiation of keratinocytes, potentially via promoting localization of DSG1 at desmosome cell junctions (By similarity). Required for calcium-independent development and maturation of desmosome plaques specifically at lateral cell-cell contacts in differentiating keratinocytes (By similarity). Plays a role in the maintenance of DSG3 protein abundance, DSG3 clustering and localization of these clusters to the cell membrane in keratinocytes (By similarity). May also promote keratinocyte proliferation and morphogenesis during postnatal development (PubMed:9326952). Required for tight junction inside-out transepidermal barrier function of the skin (By similarity). Promotes Wnt-mediated proliferation and differentiation of ameloblasts, via facilitating TJP1/ZO-1 localization to tight junctions (By similarity). Binds single-stranded DNA (ssDNA), and may thereby play a role in sensing DNA damage and promoting cell survival (PubMed:20613778). Positively regulates cap-dependent translation and as a result cell proliferation, via recruitment of EIF4A1 to the initiation complex and promotion of EIF4A1 ATPase activity (PubMed:20156963, PubMed:23444369). Regulates the mRNA stability and protein abundance of desmosome components PKP2, PKP3, DSC2 and DSP, potentially via its interaction with FXR1 (PubMed:25225333). {ECO:0000250|UniProtKB:P97350, ECO:0000269|PubMed:10852826, ECO:0000269|PubMed:20156963, ECO:0000269|PubMed:20613778, ECO:0000269|PubMed:23444369, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:31835537, ECO:0000269|PubMed:9326952}. |
| Q13885 | TUBB2A | S234 | ochoa | Tubulin beta-2A chain (Tubulin beta class IIa) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q14680 | MELK | S529 | ochoa|psp | Maternal embryonic leucine zipper kinase (hMELK) (EC 2.7.11.1) (Protein kinase Eg3) (pEg3 kinase) (Protein kinase PK38) (hPK38) (Tyrosine-protein kinase MELK) (EC 2.7.10.2) | Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis. {ECO:0000269|PubMed:11802789, ECO:0000269|PubMed:12400006, ECO:0000269|PubMed:14699119, ECO:0000269|PubMed:15908796, ECO:0000269|PubMed:16216881, ECO:0000269|PubMed:17280616}. |
| Q14766 | LTBP1 | S321 | ochoa | Latent-transforming growth factor beta-binding protein 1 (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1) | Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:2022183, PubMed:8617200, PubMed:8939931). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:15184403, PubMed:8617200, PubMed:8939931). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). {ECO:0000269|PubMed:15184403, ECO:0000269|PubMed:2022183, ECO:0000269|PubMed:22278742, ECO:0000269|PubMed:8617200, ECO:0000269|PubMed:8939931}. |
| Q14802 | FXYD3 | S69 | ochoa | FXYD domain-containing ion transport regulator 3 (Chloride conductance inducer protein Mat-8) (Mammary tumor 8 kDa protein) (Phospholemman-like) (Sodium/potassium-transporting ATPase subunit FXYD3) | Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell (PubMed:17077088). Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1 (PubMed:21454534). Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes (PubMed:7836447). {ECO:0000269|PubMed:17077088, ECO:0000269|PubMed:21454534, ECO:0000269|PubMed:7836447}.; FUNCTION: [Isoform 1]: Decreases the apparent K+ and Na+ affinity of the sodium/potassium-transporting ATPase over a large range of membrane potentials. {ECO:0000269|PubMed:17077088}.; FUNCTION: [Isoform 2]: Decreases the apparent K+ affinity of the sodium/potassium-transporting ATPase only at slightly negative and positive membrane potentials and increases the apparent Na+ affinity over a large range of membrane potentials. {ECO:0000269|PubMed:17077088}. |
| Q14D04 | VEPH1 | S449 | ochoa | Ventricular zone-expressed PH domain-containing protein homolog 1 (Protein melted) | Interacts with TGF-beta receptor type-1 (TGFBR1) and inhibits dissociation of activated SMAD2 from TGFBR1, impeding its nuclear accumulation and resulting in impaired TGF-beta signaling. May also affect FOXO, Hippo and Wnt signaling. {ECO:0000269|PubMed:26039994}. |
| Q15032 | R3HDM1 | S138 | ochoa | R3H domain-containing protein 1 | None |
| Q15233 | NONO | S262 | ochoa | Non-POU domain-containing octamer-binding protein (NonO protein) (54 kDa nuclear RNA- and DNA-binding protein) (p54(nrb)) (p54nrb) (55 kDa nuclear protein) (NMT55) (DNA-binding p52/p100 complex, 52 kDa subunit) | DNA- and RNA binding protein, involved in several nuclear processes (PubMed:11525732, PubMed:12403470, PubMed:26571461). Binds the conventional octamer sequence in double-stranded DNA (PubMed:11525732, PubMed:12403470, PubMed:26571461). Also binds single-stranded DNA and RNA at a site independent of the duplex site (PubMed:11525732, PubMed:12403470, PubMed:26571461). Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ (PubMed:11525732, PubMed:12403470, PubMed:26571461). Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b (PubMed:12403470). Together with PSPC1, required for the formation of nuclear paraspeckles (PubMed:22416126). The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs (PubMed:11525732). The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1 (PubMed:10858305). The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends (PubMed:15590677). In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex (PubMed:15590677). NONO is involved in transcriptional regulation. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity (PubMed:11897684). NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription (By similarity). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (By similarity). Important for the functional organization of GABAergic synapses (By similarity). Plays a specific and important role in the regulation of synaptic RNAs and GPHN/gephyrin scaffold structure, through the regulation of GABRA2 transcript (By similarity). Plays a key role during neuronal differentiation by recruiting TET1 to genomic loci and thereby regulating 5-hydroxymethylcytosine levels (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728, PubMed:30270045). Promotes activation of the cGAS-STING pathway in response to HIV-2 infection: acts by interacting with HIV-2 Capsid protein p24, thereby promoting detection of viral DNA by CGAS, leading to CGAS-mediated inmmune activation (PubMed:30270045). In contrast, the weak interaction with HIV-1 Capsid protein p24 does not allow activation of the cGAS-STING pathway (PubMed:30270045). {ECO:0000250|UniProtKB:Q99K48, ECO:0000269|PubMed:10858305, ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:11897684, ECO:0000269|PubMed:12403470, ECO:0000269|PubMed:15590677, ECO:0000269|PubMed:22416126, ECO:0000269|PubMed:26571461, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:30270045}. |
| Q2LD37 | BLTP1 | S2303 | ochoa | Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein) | Tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (Probable). Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as a regulator of phagocytosis (PubMed:31540829). {ECO:0000269|PubMed:30906834, ECO:0000269|PubMed:31540829, ECO:0000305|PubMed:35015055, ECO:0000305|PubMed:35491307}. |
| Q38SD2 | LRRK1 | S1064 | psp | Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1) | Serine/threonine-protein kinase which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). Phosphorylates RAB7A; this activity is dependent on protein kinase C (PKC) activation (PubMed:36040231, PubMed:37558661, PubMed:37857821). Plays a role in the negative regulation of bone mass, acting through the maturation of osteoclasts (By similarity). {ECO:0000250|UniProtKB:Q3UHC2, ECO:0000269|PubMed:36040231, ECO:0000269|PubMed:37558661, ECO:0000269|PubMed:37857821}. |
| Q5T8P6 | RBM26 | S496 | ochoa | RNA-binding protein 26 (CTCL tumor antigen se70-2) (RNA-binding motif protein 26) | May be involved in the turnover of nuclear polyadenylated (pA+) RNA. {ECO:0000269|PubMed:31950173}. |
| Q5TKA1 | LIN9 | S207 | ochoa | Protein lin-9 homolog (HuLin-9) (hLin-9) (Beta subunit-associated regulator of apoptosis) (TUDOR gene similar protein) (Type I interferon receptor beta chain-associated protein) (pRB-associated protein) | Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition. {ECO:0000269|PubMed:15538385, ECO:0000269|PubMed:16730350}. |
| Q5VTE0 | EEF1A1P5 | S224 | ochoa | Putative elongation factor 1-alpha-like 3 (EF-1-alpha-like 3) (Eukaryotic elongation factor 1 A-like 3) (eEF1A-like 3) (Eukaryotic translation elongation factor 1 alpha-1 pseudogene 5) | This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. {ECO:0000250}. |
| Q63HR2 | TNS2 | S33 | ochoa | Tensin-2 (EC 3.1.3.48) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase) | Tyrosine-protein phosphatase which regulates cell motility, proliferation and muscle-response to insulin (PubMed:15817639, PubMed:23401856). Phosphatase activity is mediated by binding to phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3) via the SH2 domain (PubMed:30092354). In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy (PubMed:23401856, PubMed:30092354). Negatively regulates PI3K-AKT pathway activation (PubMed:15817639, PubMed:23401856, PubMed:30092354). Dephosphorylates nephrin NPHS1 in podocytes which regulates activity of the mTORC1 complex (PubMed:28955049). Under normal glucose conditions, NPHS1 outcompetes IRS1 for binding to phosphatidylinositol 3-kinase (PI3K) which balances mTORC1 activity but high glucose conditions lead to up-regulation of TNS2, increased NPHS1 dephosphorylation and activation of mTORC1, contributing to podocyte hypertrophy and proteinuria (PubMed:28955049). Required for correct podocyte morphology, podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in promoting DLC1-dependent remodeling of the extracellular matrix (PubMed:20069572). {ECO:0000250|UniProtKB:Q8CGB6, ECO:0000269|PubMed:15817639, ECO:0000269|PubMed:20069572, ECO:0000269|PubMed:23401856, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:28955049, ECO:0000269|PubMed:30092354}. |
| Q66LE6 | PPP2R2D | S415 | ochoa | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform (PP2A subunit B isoform B55-delta) (PP2A subunit B isoform PR55-delta) (PP2A subunit B isoform R2-delta) (PP2A subunit B isoform delta) | Substrate-recognition subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. Involved in chromosome clustering during late mitosis by mediating dephosphorylation of MKI67 (By similarity). The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis (By similarity). {ECO:0000250|UniProtKB:Q7ZX64, ECO:0000250|UniProtKB:Q925E7}. |
| Q6NZI2 | CAVIN1 | S300 | ochoa | Caveolae-associated protein 1 (Cavin-1) (Polymerase I and transcript release factor) | Plays an important role in caveolae formation and organization. Essential for the formation of caveolae in all tissues (PubMed:18056712, PubMed:18191225, PubMed:19726876). Core component of the CAVIN complex which is essential for recruitment of the complex to the caveolae in presence of calveolin-1 (CAV1). Essential for normal oligomerization of CAV1. Promotes ribosomal transcriptional activity in response to metabolic challenges in the adipocytes and plays an important role in the formation of the ribosomal transcriptional loop. Dissociates transcription complexes paused by DNA-bound TTF1, thereby releasing both RNA polymerase I and pre-RNA from the template (By similarity) (PubMed:18056712, PubMed:18191225, PubMed:19726876). The caveolae biogenesis pathway is required for the secretion of proteins such as GASK1A (By similarity). {ECO:0000250|UniProtKB:O54724, ECO:0000269|PubMed:18056712, ECO:0000269|PubMed:18191225, ECO:0000269|PubMed:19726876}. |
| Q6P4F7 | ARHGAP11A | S606 | ochoa | Rho GTPase-activating protein 11A (Rho-type GTPase-activating protein 11A) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000269|PubMed:27957544}. |
| Q6Y7W6 | GIGYF2 | S367 | ochoa | GRB10-interacting GYF protein 2 (PERQ amino acid-rich with GYF domain-containing protein 2) (Trinucleotide repeat-containing gene 15 protein) | Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931, PubMed:31439631, PubMed:35878012). In the 4EHP-GYF2 complex, acts as a factor that bridges EIF4E2 to ZFP36/TTP, linking translation repression with mRNA decay (PubMed:31439631). Also recruits and bridges the association of the 4EHP complex with the decapping effector protein DDX6, which is required for the ZFP36/TTP-mediated down-regulation of AU-rich mRNA (PubMed:31439631). May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors (PubMed:12771153). In association with EIF4E2, assists ribosome-associated quality control (RQC) by sequestering the mRNA cap, blocking ribosome initiation and decreasing the translational load on problematic messages. Part of a pathway that works in parallel to RQC-mediated degradation of the stalled nascent polypeptide (PubMed:32726578). GIGYF2 and EIF4E2 work downstream and independently of ZNF598, which seems to work as a scaffold that can recruit them to faulty mRNA even if alternative recruitment mechanisms may exist (PubMed:32726578). {ECO:0000269|PubMed:12771153, ECO:0000269|PubMed:22751931, ECO:0000269|PubMed:31439631, ECO:0000269|PubMed:32726578, ECO:0000269|PubMed:35878012}.; FUNCTION: (Microbial infection) Upon SARS coronavirus-2/SARS-CoV-2 infection, the interaction with non-structural protein 2 (nsp2) enhances GIGYF2 binding to EIF4E2 and increases repression of translation initiation of genes involved in antiviral innate immune response such as IFNB1. {ECO:0000269|PubMed:35878012}. |
| Q71UM5 | RPS27L | S27 | ochoa|psp | Ribosomal protein eS27-like (40S ribosomal protein S27-like) (Small ribosomal subunit protein eS27-like) | None |
| Q7L804 | RAB11FIP2 | S150 | ochoa | Rab11 family-interacting protein 2 (Rab11-FIP2) (NRip11) | A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity. Plays an essential role in phagocytosis through a mechanism involving TICAM2, RAC1 and CDC42 Rho GTPases for controlling actin-dynamics. {ECO:0000269|PubMed:12364336, ECO:0000269|PubMed:15304524, ECO:0000269|PubMed:16251358, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:19542231, ECO:0000269|PubMed:30883606}. |
| Q7Z403 | TMC6 | S63 | ochoa | Transmembrane channel-like protein 6 (Epidermodysplasia verruciformis protein 1) (Protein LAK-4) | Acts as a regulatory protein involved in the regulation of numerous cellular processes (PubMed:18158319, PubMed:30068544, PubMed:32917726). Together with its homolog TMC8/EVER2, forms a complex with CIB1 in lymphocytes and keratynocytes where TMC6 and TMC8 stabilize CIB1 and reciprocally (PubMed:30068544, PubMed:32917726). Together with TMC8, also forms a complex with and activates zinc transporter ZNT1 at the ER membrane of keratynocytes, thereby facilitating zinc uptake into the ER (PubMed:18158319). Down-regulates the activity of transcription factors induced by zinc and cytokines (PubMed:18158319). Also plays a role in thermal sensation by inhibiting the M-channel (KCNQ2-KCNQ3 channel) current in primary sensory neurons (By similarity). {ECO:0000250|UniProtKB:Q7TN60, ECO:0000269|PubMed:18158319, ECO:0000269|PubMed:30068544, ECO:0000269|PubMed:32917726}. |
| Q7Z6B7 | SRGAP1 | S196 | ochoa | SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho GTPase-activating protein 13) | GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42. {ECO:0000269|PubMed:11672528}. |
| Q86Y07 | VRK2 | S406 | ochoa | Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2) | Serine/threonine kinase that regulates several signal transduction pathways (PubMed:14645249, PubMed:16495336, PubMed:16704422, PubMed:17709393, PubMed:18286207, PubMed:18617507, PubMed:20679487). Isoform 1 modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes (PubMed:17709393). Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription (PubMed:18286207). Phosphorylates 'Thr-18' of p53/TP53, histone H3, and may also phosphorylate MAPK8IP1 (PubMed:16704422). Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins (PubMed:16495336). Down-regulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1 (PubMed:20679487). Blocks the phosphorylation of ERK in response to ERBB2 and HRAS (PubMed:20679487). Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevant (PubMed:14645249). {ECO:0000269|PubMed:14645249, ECO:0000269|PubMed:16495336, ECO:0000269|PubMed:16704422, ECO:0000269|PubMed:17709393, ECO:0000269|PubMed:18286207, ECO:0000269|PubMed:18617507, ECO:0000269|PubMed:20679487}.; FUNCTION: [Isoform 2]: Phosphorylates 'Thr-18' of p53/TP53, as well as histone H3. Reduces p53/TP53 ubiquitination by MDM2, promotes p53/TP53 acetylation by EP300 and thereby increases p53/TP53 stability and activity. {ECO:0000269|PubMed:16704422}. |
| Q86YP4 | GATAD2A | S512 | ochoa | Transcriptional repressor p66-alpha (Hp66alpha) (GATA zinc finger domain-containing protein 2A) | Transcriptional repressor (PubMed:12183469, PubMed:16415179). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Enhances MBD2-mediated repression (PubMed:12183469, PubMed:16415179). Efficient repression requires the presence of GATAD2B (PubMed:16415179). {ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}. |
| Q8IUW5 | RELL1 | S249 | ochoa | RELT-like protein 1 | Induces activation of MAPK14/p38 cascade, when overexpressed (PubMed:28688764). Induces apoptosis, when overexpressed (PubMed:19969290). {ECO:0000269|PubMed:19969290, ECO:0000269|PubMed:28688764}. |
| Q8IV36 | HID1 | S589 | ochoa | Protein HID1 (Down-regulated in multiple cancers 1) (HID1 domain-containing protein) (Protein hid-1 homolog) | May play an important role in the development of cancers in a broad range of tissues. {ECO:0000269|PubMed:11281419}. |
| Q8IZ41 | RASEF | S719 | ochoa | Ras and EF-hand domain-containing protein (Ras-related protein Rab-45) | Binds predominantly GDP, and also GTP (PubMed:17448446). Acts as a dynein adapter protein that activates dynein-mediated transport and dynein-dynactin motility on microtubules (PubMed:30814157). {ECO:0000269|PubMed:17448446, ECO:0000269|PubMed:30814157}. |
| Q8N0Y2 | ZNF444 | S232 | ochoa | Zinc finger protein 444 (Endothelial zinc finger protein 2) (EZF-2) (Zinc finger and SCAN domain-containing protein 17) | Transcriptional regulator. Binds to the 5'-flanking critical region of the SCARF1 promoter. |
| Q8N3K9 | CMYA5 | S142 | ochoa | Cardiomyopathy-associated protein 5 (Dystrobrevin-binding protein 2) (Genethonin-3) (Myospryn) (SPRY domain-containing protein 2) (Tripartite motif-containing protein 76) | May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity). Plays a role in the assembly of ryanodine receptor (RYR2) clusters in striated muscle (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q70KF4}. |
| Q8TF71 | SLC16A10 | S266 | ochoa | Monocarboxylate transporter 10 (MCT 10) (Aromatic amino acid transporter 1) (Solute carrier family 16 member 10) (T-type amino acid transporter 1) | Sodium- and proton-independent thyroid hormones and aromatic acids transporter (PubMed:11827462, PubMed:18337592, PubMed:28754537). Mediates both uptake and efflux of 3,5,3'-triiodothyronine (T3) and 3,5,3',5'-tetraiodothyronine (T4) with high affinity, suggesting a role in the homeostasis of thyroid hormone levels (PubMed:18337592). Responsible for low affinity bidirectional transport of the aromatic amino acids, such as phenylalanine, tyrosine, tryptophan and L-3,4-dihydroxyphenylalanine (L-dopa) (PubMed:11827462, PubMed:28754537). Plays an important role in homeostasis of aromatic amino acids (By similarity). {ECO:0000250|UniProtKB:Q3U9N9, ECO:0000269|PubMed:11827462, ECO:0000269|PubMed:18337592, ECO:0000269|PubMed:28754537}. |
| Q8WU79 | SMAP2 | S180 | ochoa | Stromal membrane-associated protein 2 (Stromal membrane-associated protein 1-like) | GTPase activating protein that acts on ARF1. Can also activate ARF6 (in vitro). May play a role in clathrin-dependent retrograde transport from early endosomes to the trans-Golgi network (By similarity). {ECO:0000250}. |
| Q8WW12 | PCNP | S142 | ochoa | PEST proteolytic signal-containing nuclear protein (PCNP) (PEST-containing nuclear protein) | May be involved in cell cycle regulation. |
| Q8WYP5 | AHCTF1 | S2181 | ochoa | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}. |
| Q96C24 | SYTL4 | S509 | ochoa | Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin) | Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By similarity). {ECO:0000250}. |
| Q96DG6 | CMBL | S208 | ochoa | Carboxymethylenebutenolidase homolog (EC 3.1.-.-) | Cysteine hydrolase. Can convert the prodrug olmesartan medoxomil into its pharmacologically active metabolite olmerstatan, an angiotensin receptor blocker, in liver and intestine. May also activate beta-lactam antibiotics faropenem medoxomil and lenampicillin. {ECO:0000269|PubMed:20177059}. |
| Q99618 | CDCA3 | S165 | ochoa | Cell division cycle-associated protein 3 (Gene-rich cluster protein C8) (Trigger of mitotic entry protein 1) (TOME-1) | F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase (By similarity). {ECO:0000250}. |
| Q9BVA1 | TUBB2B | S234 | ochoa | Tubulin beta-2B chain | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:23001566, PubMed:26732629, PubMed:28013290). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910). {ECO:0000269|PubMed:19465910, ECO:0000269|PubMed:23001566, ECO:0000269|PubMed:26732629, ECO:0000269|PubMed:28013290}. |
| Q9BYW2 | SETD2 | S939 | ochoa | Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) | Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}. |
| Q9BYW2 | SETD2 | S2085 | ochoa | Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) | Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}. |
| Q9C0C9 | UBE2O | S904 | ochoa | (E3-independent) E2 ubiquitin-conjugating enzyme (EC 2.3.2.24) (E2/E3 hybrid ubiquitin-protein ligase UBE2O) (Ubiquitin carrier protein O) (Ubiquitin-conjugating enzyme E2 O) (Ubiquitin-conjugating enzyme E2 of 230 kDa) (Ubiquitin-conjugating enzyme E2-230K) (Ubiquitin-protein ligase O) | E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). {ECO:0000269|PubMed:23381138, ECO:0000269|PubMed:23452853, ECO:0000269|PubMed:23455153, ECO:0000269|PubMed:24703950}. |
| Q9GZR2 | REXO4 | S128 | ochoa | RNA exonuclease 4 (EC 3.1.-.-) (Exonuclease XPMC2) (Prevents mitotic catastrophe 2 protein homolog) (hPMC2) | None |
| Q9H6H4 | REEP4 | S114 | ochoa | Receptor expression-enhancing protein 4 | Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes. {ECO:0000269|PubMed:23911198}. |
| Q9NR80 | ARHGEF4 | S109 | ochoa | Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor 1) (Asef) (Asef1) | Acts as a guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. {ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:12598901, ECO:0000269|PubMed:17145773, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19893577}. |
| Q9P2D0 | IBTK | S1069 | ochoa | Inhibitor of Bruton tyrosine kinase (IBtk) | Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription. {ECO:0000269|PubMed:11577348}. |
| Q9P2N5 | RBM27 | S120 | ochoa | RNA-binding protein 27 (RNA-binding motif protein 27) | May be involved in the turnover of nuclear polyadenylated (pA+) RNA. {ECO:0000269|PubMed:31950173}. |
| Q9UBU7 | DBF4 | S413 | ochoa | Protein DBF4 homolog A (Activator of S phase kinase) (Chiffon homolog A) (DBF4-type zinc finger-containing protein 1) | Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle. {ECO:0000269|PubMed:10373557, ECO:0000269|PubMed:10523313, ECO:0000269|PubMed:17062569}. |
| Q9UEW8 | STK39 | S309 | psp | STE20/SPS1-related proline-alanine-rich protein kinase (Ste-20-related kinase) (EC 2.7.11.1) (DCHT) (Serine/threonine-protein kinase 39) | Effector serine/threonine-protein kinase component of the WNK-SPAK/OSR1 kinase cascade, which is involved in various processes, such as ion transport, response to hypertonic stress and blood pressure (PubMed:16669787, PubMed:18270262, PubMed:21321328, PubMed:34289367). Specifically recognizes and binds proteins with a RFXV motif (PubMed:16669787, PubMed:21321328). Acts downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4): following activation by WNK kinases, catalyzes phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:21321328). Mediates regulatory volume increase in response to hyperosmotic stress by catalyzing phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1 and SLC12A6/KCC3 downstream of WNK1 and WNK3 kinases (PubMed:12740379, PubMed:16669787, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:16669787, PubMed:19665974, PubMed:21321328). Acts as a regulator of NaCl reabsorption in the distal nephron by mediating phosphorylation and activation of the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney downstream of WNK4 (PubMed:18270262). Mediates the inhibition of SLC4A4, SLC26A6 as well as CFTR activities (By similarity). Phosphorylates RELT (By similarity). {ECO:0000250|UniProtKB:Q9Z1W9, ECO:0000269|PubMed:12740379, ECO:0000269|PubMed:16669787, ECO:0000269|PubMed:18270262, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:34289367}. |
| Q9UHB6 | LIMA1 | S263 | ochoa | LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) | Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}. |
| Q9UK61 | TASOR | S633 | ochoa | Protein TASOR (CTCL tumor antigen se89-1) (Retinoblastoma-associated protein RAP140) (Transgene activation suppressor protein) | Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression (PubMed:26022416, PubMed:28581500). The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Plays a crucial role in early embryonic development (By similarity). Involved in the organization of spindle poles and spindle apparatus assembly during zygotic division (By similarity). Plays an important role in maintaining epiblast fitness or potency (By similarity). {ECO:0000250|UniProtKB:Q69ZR9, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}. |
| Q9UKI8 | TLK1 | S357 | ochoa | Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (PKU-beta) (Tousled-like kinase 1) | Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:10588641, ECO:0000269|PubMed:11314006, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:9427565}. |
| Q9UKY7 | CDV3 | S216 | ochoa | Protein CDV3 homolog | None |
| Q9UQ35 | SRRM2 | S144 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y2K5 | R3HDM2 | S139 | ochoa | R3H domain-containing protein 2 | None |
| Q9Y520 | PRRC2C | S651 | ochoa | Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) | Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}. |
| U3KPZ7 | LOC127814297 | S120 | ochoa | RNA-binding protein 27 (RNA-binding motif protein 27) | May be involved in the turnover of nuclear polyadenylated (pA+) RNA. {ECO:0000256|ARBA:ARBA00043866}. |
| P05771 | PRKCB | S85 | Sugiyama | Protein kinase C beta type (PKC-B) (PKC-beta) (EC 2.7.11.13) | Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity (PubMed:11598012). Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A (PubMed:20228790). In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. Participates in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4. Phosphorylates SLC2A1/GLUT1, promoting glucose uptake by SLC2A1/GLUT1 (PubMed:25982116). Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis (By similarity). Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription (PubMed:19176525). Phosphorylates KLHL3 in response to angiotensin II signaling, decreasing the interaction between KLHL3 and WNK4 (PubMed:25313067). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000250|UniProtKB:P68404, ECO:0000269|PubMed:11598012, ECO:0000269|PubMed:19176525, ECO:0000269|PubMed:20228790, ECO:0000269|PubMed:25313067, ECO:0000269|PubMed:25982116, ECO:0000269|PubMed:36040231}. |
| P17252 | PRKCA | S85 | Sugiyama | Protein kinase C alpha type (PKC-A) (PKC-alpha) (EC 2.7.11.13) | Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation in glioma cells. In intestinal cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppressive form of RB1 and induction of the CDK inhibitors CDKN1A and CDKN1B. Exhibits anti-apoptotic function in glioma cells and protects them from apoptosis by suppressing the p53/TP53-mediated activation of IGFBP3, and in leukemia cells mediates anti-apoptotic action by phosphorylating BCL2. During macrophage differentiation induced by macrophage colony-stimulating factor (CSF1), is translocated to the nucleus and is associated with macrophage development. After wounding, translocates from focal contacts to lamellipodia and participates in the modulation of desmosomal adhesion. Plays a role in cell motility by phosphorylating CSPG4, which induces association of CSPG4 with extensive lamellipodia at the cell periphery and polarization of the cell accompanied by increases in cell motility. During chemokine-induced CD4(+) T cell migration, phosphorylates CDC42-guanine exchange factor DOCK8 resulting in its dissociation from LRCH1 and the activation of GTPase CDC42 (PubMed:28028151). Is highly expressed in a number of cancer cells where it can act as a tumor promoter and is implicated in malignant phenotypes of several tumors such as gliomas and breast cancers. Negatively regulates myocardial contractility and positively regulates angiogenesis, platelet aggregation and thrombus formation in arteries. Mediates hypertrophic growth of neonatal cardiomyocytes, in part through a MAPK1/3 (ERK1/2)-dependent signaling pathway, and upon PMA treatment, is required to induce cardiomyocyte hypertrophy up to heart failure and death, by increasing protein synthesis, protein-DNA ratio and cell surface area. Regulates cardiomyocyte function by phosphorylating cardiac troponin T (TNNT2/CTNT), which induces significant reduction in actomyosin ATPase activity, myofilament calcium sensitivity and myocardial contractility. In angiogenesis, is required for full endothelial cell migration, adhesion to vitronectin (VTN), and vascular endothelial growth factor A (VEGFA)-dependent regulation of kinase activation and vascular tube formation. Involved in the stabilization of VEGFA mRNA at post-transcriptional level and mediates VEGFA-induced cell proliferation. In the regulation of calcium-induced platelet aggregation, mediates signals from the CD36/GP4 receptor for granule release, and activates the integrin heterodimer ITGA2B-ITGB3 through the RAP1GAP pathway for adhesion. During response to lipopolysaccharides (LPS), may regulate selective LPS-induced macrophage functions involved in host defense and inflammation. But in some inflammatory responses, may negatively regulate NF-kappa-B-induced genes, through IL1A-dependent induction of NF-kappa-B inhibitor alpha (NFKBIA/IKBA). Upon stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA), phosphorylates EIF4G1, which modulates EIF4G1 binding to MKNK1 and may be involved in the regulation of EIF4E phosphorylation. Phosphorylates KIT, leading to inhibition of KIT activity. Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription. Phosphorylates SOCS2 at 'Ser-52' facilitating its ubiquitination and proteasomal degradation (By similarity). Phosphorylates KLHL3 in response to angiotensin II signaling, decreasing the interaction between KLHL3 and WNK4 (PubMed:25313067). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000250|UniProtKB:P20444, ECO:0000269|PubMed:10848585, ECO:0000269|PubMed:11909826, ECO:0000269|PubMed:12724315, ECO:0000269|PubMed:12832403, ECO:0000269|PubMed:15016832, ECO:0000269|PubMed:15504744, ECO:0000269|PubMed:15526160, ECO:0000269|PubMed:18056764, ECO:0000269|PubMed:19176525, ECO:0000269|PubMed:21576361, ECO:0000269|PubMed:21806543, ECO:0000269|PubMed:23990668, ECO:0000269|PubMed:25313067, ECO:0000269|PubMed:28028151, ECO:0000269|PubMed:36040231, ECO:0000269|PubMed:9738012, ECO:0000269|PubMed:9830023, ECO:0000269|PubMed:9873035, ECO:0000269|PubMed:9927633}. |
| Q9H0B6 | KLC2 | Y431 | Sugiyama | Kinesin light chain 2 (KLC 2) | Kinesin is a microtubule-associated force-producing protein that plays a role in organelle transport. The light chain functions in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (Probable). Through binding with PLEKHM2 and ARL8B, recruits kinesin-1 to lysosomes and hence direct lysosomes movement toward microtubule plus ends (PubMed:22172677). {ECO:0000269|PubMed:22172677, ECO:0000305|PubMed:22172677}. |
| O95263 | PDE8B | S401 | Sugiyama | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (HsPDE8B) (EC 3.1.4.53) (Cell proliferation-inducing gene 22 protein) | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland. |
| P07237 | P4HB | S449 | Sugiyama | Protein disulfide-isomerase (PDI) (EC 5.3.4.1) (Cellular thyroid hormone-binding protein) (Prolyl 4-hydroxylase subunit beta) (p55) | This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations and following phosphorylation by FAM20C, functions as a chaperone that inhibits aggregation of misfolded proteins (PubMed:32149426). At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts as a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307). {ECO:0000269|PubMed:10636893, ECO:0000269|PubMed:12485997, ECO:0000269|PubMed:21670307, ECO:0000269|PubMed:32149426}. |
| Q96EP5 | DAZAP1 | S195 | Sugiyama | DAZ-associated protein 1 (Deleted in azoospermia-associated protein 1) | RNA-binding protein, which may be required during spermatogenesis. |
| Q9NTX5 | ECHDC1 | S113 | Sugiyama | Ethylmalonyl-CoA decarboxylase (EC 4.1.1.94) (Enoyl-CoA hydratase domain-containing protein 1) (Methylmalonyl-CoA decarboxylase) (MMCD) | Decarboxylates ethylmalonyl-CoA, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading (PubMed:22016388). Acts preferentially on (S)-ethylmalonyl-CoA but also has some activity on the (R)-isomer (By similarity). Also has methylmalonyl-CoA decarboxylase activity at lower level (By similarity). {ECO:0000250|UniProtKB:Q9D9V3, ECO:0000269|PubMed:22016388}. |
| Q9UM73 | ALK | S1538 | Sugiyama | ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246) | Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system (PubMed:11121404, PubMed:11387242, PubMed:16317043, PubMed:17274988, PubMed:30061385, PubMed:34646012, PubMed:34819673). Also acts as a key thinness protein involved in the resistance to weight gain: in hypothalamic neurons, controls energy expenditure acting as a negative regulator of white adipose tissue lipolysis and sympathetic tone to fine-tune energy homeostasis (By similarity). Following activation by ALKAL2 ligand at the cell surface, transduces an extracellular signal into an intracellular response (PubMed:30061385, PubMed:33411331, PubMed:34646012, PubMed:34819673). In contrast, ALKAL1 is not a potent physiological ligand for ALK (PubMed:34646012). Ligand-binding to the extracellular domain induces tyrosine kinase activation, leading to activation of the mitogen-activated protein kinase (MAPK) pathway (PubMed:34819673). Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif (PubMed:15226403, PubMed:16878150). Induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1 (PubMed:15226403, PubMed:16878150). ALK activation may also be regulated by pleiotrophin (PTN) and midkine (MDK) (PubMed:11278720, PubMed:11809760, PubMed:12107166, PubMed:12122009). PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation (PubMed:11278720, PubMed:11809760, PubMed:12107166). MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction (PubMed:12122009). Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase (PubMed:15226403, PubMed:16878150). Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK (PubMed:15226403, PubMed:16878150). {ECO:0000250|UniProtKB:P97793, ECO:0000269|PubMed:11121404, ECO:0000269|PubMed:11278720, ECO:0000269|PubMed:11387242, ECO:0000269|PubMed:11809760, ECO:0000269|PubMed:12107166, ECO:0000269|PubMed:12122009, ECO:0000269|PubMed:15226403, ECO:0000269|PubMed:16317043, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:17274988, ECO:0000269|PubMed:30061385, ECO:0000269|PubMed:33411331, ECO:0000269|PubMed:34646012, ECO:0000269|PubMed:34819673}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-68886 | M Phase | 2.916422e-08 | 7.535 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 6.956222e-07 | 6.158 |
| R-HSA-68882 | Mitotic Anaphase | 5.261599e-07 | 6.279 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 6.741209e-07 | 6.171 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 5.498351e-07 | 6.260 |
| R-HSA-69278 | Cell Cycle, Mitotic | 2.566747e-07 | 6.591 |
| R-HSA-1640170 | Cell Cycle | 3.790578e-07 | 6.421 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 1.137784e-06 | 5.944 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 1.411911e-06 | 5.850 |
| R-HSA-983189 | Kinesins | 1.526078e-06 | 5.816 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 1.696754e-06 | 5.770 |
| R-HSA-2467813 | Separation of Sister Chromatids | 2.463556e-06 | 5.608 |
| R-HSA-437239 | Recycling pathway of L1 | 6.305089e-06 | 5.200 |
| R-HSA-68877 | Mitotic Prometaphase | 9.263614e-06 | 5.033 |
| R-HSA-5661231 | Metallothioneins bind metals | 9.717085e-06 | 5.012 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 9.290183e-06 | 5.032 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 1.786846e-05 | 4.748 |
| R-HSA-190861 | Gap junction assembly | 2.265374e-05 | 4.645 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 2.430460e-05 | 4.614 |
| R-HSA-5660526 | Response to metal ions | 2.795767e-05 | 4.553 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 2.818231e-05 | 4.550 |
| R-HSA-9646399 | Aggrephagy | 4.316076e-05 | 4.365 |
| R-HSA-69275 | G2/M Transition | 4.562121e-05 | 4.341 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 4.912634e-05 | 4.309 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 5.248595e-05 | 4.280 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 5.478333e-05 | 4.261 |
| R-HSA-190828 | Gap junction trafficking | 6.930694e-05 | 4.159 |
| R-HSA-9833482 | PKR-mediated signaling | 8.534542e-05 | 4.069 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 9.000662e-05 | 4.046 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 9.677304e-05 | 4.014 |
| R-HSA-157858 | Gap junction trafficking and regulation | 1.062441e-04 | 3.974 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 1.101457e-04 | 3.958 |
| R-HSA-2132295 | MHC class II antigen presentation | 1.304938e-04 | 3.884 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 1.443914e-04 | 3.840 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 1.686751e-04 | 3.773 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 1.859433e-04 | 3.731 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 2.084416e-04 | 3.681 |
| R-HSA-3247509 | Chromatin modifying enzymes | 2.264012e-04 | 3.645 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 2.438083e-04 | 3.613 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 2.440876e-04 | 3.612 |
| R-HSA-4839726 | Chromatin organization | 3.433393e-04 | 3.464 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 3.967710e-04 | 3.401 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 4.724310e-04 | 3.326 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 5.285883e-04 | 3.277 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 6.461140e-04 | 3.190 |
| R-HSA-373760 | L1CAM interactions | 6.756801e-04 | 3.170 |
| R-HSA-438064 | Post NMDA receptor activation events | 1.124022e-03 | 2.949 |
| R-HSA-5620924 | Intraflagellar transport | 1.139633e-03 | 2.943 |
| R-HSA-9663891 | Selective autophagy | 1.176330e-03 | 2.929 |
| R-HSA-913531 | Interferon Signaling | 1.617832e-03 | 2.791 |
| R-HSA-5358351 | Signaling by Hedgehog | 1.651856e-03 | 2.782 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 1.869711e-03 | 2.728 |
| R-HSA-69620 | Cell Cycle Checkpoints | 1.897077e-03 | 2.722 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 2.033674e-03 | 2.692 |
| R-HSA-5610787 | Hedgehog 'off' state | 2.112804e-03 | 2.675 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 2.281153e-03 | 2.642 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 2.253737e-03 | 2.647 |
| R-HSA-8953897 | Cellular responses to stimuli | 2.443994e-03 | 2.612 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 2.281153e-03 | 2.642 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 2.764412e-03 | 2.558 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 2.797291e-03 | 2.553 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 2.911406e-03 | 2.536 |
| R-HSA-9612973 | Autophagy | 2.925095e-03 | 2.534 |
| R-HSA-114516 | Disinhibition of SNARE formation | 3.021285e-03 | 2.520 |
| R-HSA-9675108 | Nervous system development | 3.451445e-03 | 2.462 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 3.582379e-03 | 2.446 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 3.636708e-03 | 2.439 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 3.636708e-03 | 2.439 |
| R-HSA-9930044 | Nuclear RNA decay | 3.955539e-03 | 2.403 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 4.542953e-03 | 2.343 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 5.026626e-03 | 2.299 |
| R-HSA-68875 | Mitotic Prophase | 4.686351e-03 | 2.329 |
| R-HSA-73864 | RNA Polymerase I Transcription | 5.276828e-03 | 2.278 |
| R-HSA-422475 | Axon guidance | 6.016644e-03 | 2.221 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 6.233237e-03 | 2.205 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 6.314422e-03 | 2.200 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 6.610392e-03 | 2.180 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 7.173870e-03 | 2.144 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 7.173870e-03 | 2.144 |
| R-HSA-5617833 | Cilium Assembly | 7.017251e-03 | 2.154 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 7.709912e-03 | 2.113 |
| R-HSA-1266738 | Developmental Biology | 6.897408e-03 | 2.161 |
| R-HSA-9700649 | Drug resistance of ALK mutants | 7.979174e-03 | 2.098 |
| R-HSA-9717329 | lorlatinib-resistant ALK mutants | 7.979174e-03 | 2.098 |
| R-HSA-9717319 | brigatinib-resistant ALK mutants | 7.979174e-03 | 2.098 |
| R-HSA-9717264 | ASP-3026-resistant ALK mutants | 7.979174e-03 | 2.098 |
| R-HSA-9717323 | ceritinib-resistant ALK mutants | 7.979174e-03 | 2.098 |
| R-HSA-9717301 | NVP-TAE684-resistant ALK mutants | 7.979174e-03 | 2.098 |
| R-HSA-9717326 | crizotinib-resistant ALK mutants | 7.979174e-03 | 2.098 |
| R-HSA-9717316 | alectinib-resistant ALK mutants | 7.979174e-03 | 2.098 |
| R-HSA-9661070 | Defective translocation of RB1 mutants to the nucleus | 7.979174e-03 | 2.098 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 7.979174e-03 | 2.098 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 9.474327e-03 | 2.023 |
| R-HSA-391251 | Protein folding | 9.474327e-03 | 2.023 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 9.084444e-03 | 2.042 |
| R-HSA-1632852 | Macroautophagy | 9.187467e-03 | 2.037 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 1.066164e-02 | 1.972 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 1.147172e-02 | 1.940 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 1.258230e-02 | 1.900 |
| R-HSA-109582 | Hemostasis | 1.280243e-02 | 1.893 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 1.473209e-02 | 1.832 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 1.493706e-02 | 1.826 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 1.493706e-02 | 1.826 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 1.540343e-02 | 1.812 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 1.576593e-02 | 1.802 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 1.589517e-02 | 1.799 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 1.589517e-02 | 1.799 |
| R-HSA-169131 | Inhibition of PKR | 1.589517e-02 | 1.799 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 1.774370e-02 | 1.751 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 1.985360e-02 | 1.702 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 1.985360e-02 | 1.702 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 1.706979e-02 | 1.768 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 2.016253e-02 | 1.695 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 2.048151e-02 | 1.689 |
| R-HSA-112315 | Transmission across Chemical Synapses | 2.102076e-02 | 1.677 |
| R-HSA-9824446 | Viral Infection Pathways | 2.157753e-02 | 1.666 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 2.209607e-02 | 1.656 |
| R-HSA-5693606 | DNA Double Strand Break Response | 2.287306e-02 | 1.641 |
| R-HSA-163282 | Mitochondrial transcription initiation | 2.374849e-02 | 1.624 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 2.529250e-02 | 1.597 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 2.529250e-02 | 1.597 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 2.784449e-02 | 1.555 |
| R-HSA-380287 | Centrosome maturation | 2.961928e-02 | 1.528 |
| R-HSA-75944 | Transcription from mitochondrial promoters | 3.153961e-02 | 1.501 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 2.612845e-02 | 1.583 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 2.612845e-02 | 1.583 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 2.612845e-02 | 1.583 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 2.603587e-02 | 1.584 |
| R-HSA-69481 | G2/M Checkpoints | 2.795703e-02 | 1.554 |
| R-HSA-69206 | G1/S Transition | 2.673396e-02 | 1.573 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 3.052864e-02 | 1.515 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 3.239119e-02 | 1.490 |
| R-HSA-9609690 | HCMV Early Events | 3.005760e-02 | 1.522 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 2.697912e-02 | 1.569 |
| R-HSA-4086400 | PCP/CE pathway | 3.239119e-02 | 1.490 |
| R-HSA-9020591 | Interleukin-12 signaling | 3.052864e-02 | 1.515 |
| R-HSA-376176 | Signaling by ROBO receptors | 3.378446e-02 | 1.471 |
| R-HSA-399719 | Trafficking of AMPA receptors | 3.596189e-02 | 1.444 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 3.773779e-02 | 1.423 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 3.832700e-02 | 1.416 |
| R-HSA-162582 | Signal Transduction | 3.839708e-02 | 1.416 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 3.926904e-02 | 1.406 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 3.926904e-02 | 1.406 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 3.954668e-02 | 1.403 |
| R-HSA-447115 | Interleukin-12 family signaling | 4.257114e-02 | 1.371 |
| R-HSA-9679506 | SARS-CoV Infections | 4.270232e-02 | 1.370 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 4.326097e-02 | 1.364 |
| R-HSA-156902 | Peptide chain elongation | 4.366760e-02 | 1.360 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 4.516511e-02 | 1.345 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 4.516511e-02 | 1.345 |
| R-HSA-2559585 | Oncogene Induced Senescence | 4.516511e-02 | 1.345 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 4.590267e-02 | 1.338 |
| R-HSA-9679191 | Potential therapeutics for SARS | 4.688844e-02 | 1.329 |
| R-HSA-69200 | Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 ... | 4.693725e-02 | 1.328 |
| R-HSA-9851151 | MDK and PTN in ALK signaling | 4.693725e-02 | 1.328 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 4.857942e-02 | 1.314 |
| R-HSA-201556 | Signaling by ALK | 5.308099e-02 | 1.275 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 5.513184e-02 | 1.259 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 5.513184e-02 | 1.259 |
| R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 6.209195e-02 | 1.207 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 7.022952e-02 | 1.153 |
| R-HSA-69231 | Cyclin D associated events in G1 | 6.578892e-02 | 1.182 |
| R-HSA-69236 | G1 Phase | 6.578892e-02 | 1.182 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 5.721029e-02 | 1.243 |
| R-HSA-8866423 | VLDL assembly | 6.957939e-02 | 1.158 |
| R-HSA-3214858 | RMTs methylate histone arginines | 6.578892e-02 | 1.182 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 6.144774e-02 | 1.211 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 6.937006e-02 | 1.159 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 6.937006e-02 | 1.159 |
| R-HSA-9609646 | HCMV Infection | 6.691899e-02 | 1.174 |
| R-HSA-75153 | Apoptotic execution phase | 7.022952e-02 | 1.153 |
| R-HSA-2262752 | Cellular responses to stress | 7.379132e-02 | 1.132 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 7.476534e-02 | 1.126 |
| R-HSA-9732724 | IFNG signaling activates MAPKs | 7.700751e-02 | 1.113 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 7.700751e-02 | 1.113 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 8.437679e-02 | 1.074 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 8.437679e-02 | 1.074 |
| R-HSA-9700645 | ALK mutants bind TKIs | 9.168768e-02 | 1.038 |
| R-HSA-4839744 | Signaling by APC mutants | 1.061361e-01 | 0.974 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 1.061361e-01 | 0.974 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 1.061361e-01 | 0.974 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 1.061361e-01 | 0.974 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 1.132746e-01 | 0.946 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 1.132746e-01 | 0.946 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 1.203565e-01 | 0.920 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 1.203565e-01 | 0.920 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 1.203565e-01 | 0.920 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 1.203565e-01 | 0.920 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 1.203565e-01 | 0.920 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 1.273823e-01 | 0.895 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 1.273823e-01 | 0.895 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 1.412673e-01 | 0.850 |
| R-HSA-73780 | RNA Polymerase III Chain Elongation | 1.412673e-01 | 0.850 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 1.481273e-01 | 0.829 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 1.549330e-01 | 0.810 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 1.549330e-01 | 0.810 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 1.683828e-01 | 0.774 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 1.750279e-01 | 0.757 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 1.816203e-01 | 0.741 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 1.816203e-01 | 0.741 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 1.816203e-01 | 0.741 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 1.816203e-01 | 0.741 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 1.816203e-01 | 0.741 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 1.816203e-01 | 0.741 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 1.881604e-01 | 0.725 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 8.410638e-02 | 1.075 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 8.649488e-02 | 1.063 |
| R-HSA-72649 | Translation initiation complex formation | 8.890371e-02 | 1.051 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 2.200911e-01 | 0.657 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 9.378050e-02 | 1.028 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 7.837007e-02 | 1.106 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 7.837007e-02 | 1.106 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 1.913762e-01 | 0.718 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 1.942659e-01 | 0.712 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 2.058785e-01 | 0.686 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 2.087939e-01 | 0.680 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 2.175652e-01 | 0.662 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 2.263261e-01 | 0.645 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 1.603777e-01 | 0.795 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 1.549330e-01 | 0.810 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 1.939629e-01 | 0.712 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 1.600471e-01 | 0.796 |
| R-HSA-444473 | Formyl peptide receptors bind formyl peptides and many other ligands | 8.437679e-02 | 1.074 |
| R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 1.132746e-01 | 0.946 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 1.549330e-01 | 0.810 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 8.649488e-02 | 1.063 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 9.133241e-02 | 1.039 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 1.298448e-01 | 0.887 |
| R-HSA-72764 | Eukaryotic Translation Termination | 2.087939e-01 | 0.680 |
| R-HSA-6798695 | Neutrophil degranulation | 9.052817e-02 | 1.043 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 9.378050e-02 | 1.028 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 1.584614e-01 | 0.800 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 9.168768e-02 | 1.038 |
| R-HSA-4839735 | Signaling by AXIN mutants | 1.132746e-01 | 0.946 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 1.132746e-01 | 0.946 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 1.273823e-01 | 0.895 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 1.273823e-01 | 0.895 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 1.750279e-01 | 0.757 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 1.946486e-01 | 0.711 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 2.010854e-01 | 0.697 |
| R-HSA-9948299 | Ribosome-associated quality control | 1.288569e-01 | 0.890 |
| R-HSA-9010642 | ROBO receptors bind AKAP5 | 8.437679e-02 | 1.074 |
| R-HSA-8963888 | Chylomicron assembly | 1.061361e-01 | 0.974 |
| R-HSA-156711 | Polo-like kinase mediated events | 1.683828e-01 | 0.774 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 2.010854e-01 | 0.697 |
| R-HSA-3214815 | HDACs deacetylate histones | 9.133241e-02 | 1.039 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 2.263261e-01 | 0.645 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 1.245099e-01 | 0.905 |
| R-HSA-8964041 | LDL remodeling | 7.700751e-02 | 1.113 |
| R-HSA-1433617 | Regulation of signaling by NODAL | 9.168768e-02 | 1.038 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 9.894064e-02 | 1.005 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 9.873307e-02 | 1.006 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 1.684977e-01 | 0.773 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 8.173869e-02 | 1.088 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 2.200911e-01 | 0.657 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 2.200911e-01 | 0.657 |
| R-HSA-399997 | Acetylcholine regulates insulin secretion | 1.549330e-01 | 0.810 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 1.183209e-01 | 0.927 |
| R-HSA-2408557 | Selenocysteine synthesis | 2.263690e-01 | 0.645 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 2.138063e-01 | 0.670 |
| R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 9.168768e-02 | 1.038 |
| R-HSA-9839394 | TGFBR3 expression | 2.200911e-01 | 0.657 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 1.406691e-01 | 0.852 |
| R-HSA-418597 | G alpha (z) signalling events | 9.133241e-02 | 1.039 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 9.168768e-02 | 1.038 |
| R-HSA-8876725 | Protein methylation | 1.412673e-01 | 0.850 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 1.750279e-01 | 0.757 |
| R-HSA-877300 | Interferon gamma signaling | 1.700642e-01 | 0.769 |
| R-HSA-9762293 | Regulation of CDH11 gene transcription | 9.168768e-02 | 1.038 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 1.088512e-01 | 0.963 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 1.683828e-01 | 0.774 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 1.343524e-01 | 0.872 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 1.412673e-01 | 0.850 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 8.173869e-02 | 1.088 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 1.298448e-01 | 0.887 |
| R-HSA-3214847 | HATs acetylate histones | 2.204965e-01 | 0.657 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 1.481273e-01 | 0.829 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 1.273823e-01 | 0.895 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 1.343524e-01 | 0.872 |
| R-HSA-9675151 | Disorders of Developmental Biology | 1.549330e-01 | 0.810 |
| R-HSA-1181150 | Signaling by NODAL | 1.816203e-01 | 0.741 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 8.890371e-02 | 1.051 |
| R-HSA-5689901 | Metalloprotease DUBs | 2.263261e-01 | 0.645 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 1.192305e-01 | 0.924 |
| R-HSA-195721 | Signaling by WNT | 1.132540e-01 | 0.946 |
| R-HSA-8963898 | Plasma lipoprotein assembly | 2.138063e-01 | 0.670 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 1.565523e-01 | 0.805 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 9.168768e-02 | 1.038 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 1.412673e-01 | 0.850 |
| R-HSA-392517 | Rap1 signalling | 1.750279e-01 | 0.757 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 1.298448e-01 | 0.887 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 1.037578e-01 | 0.984 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 2.207257e-01 | 0.656 |
| R-HSA-1433559 | Regulation of KIT signaling | 1.343524e-01 | 0.872 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 1.481273e-01 | 0.829 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 1.600471e-01 | 0.796 |
| R-HSA-3214842 | HDMs demethylate histones | 2.200911e-01 | 0.657 |
| R-HSA-69242 | S Phase | 1.489906e-01 | 0.827 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 1.980263e-01 | 0.703 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 8.437679e-02 | 1.074 |
| R-HSA-9020933 | Interleukin-23 signaling | 8.437679e-02 | 1.074 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 9.524957e-02 | 1.021 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 2.146375e-01 | 0.668 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 1.352322e-01 | 0.869 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 1.253081e-01 | 0.902 |
| R-HSA-199991 | Membrane Trafficking | 8.962805e-02 | 1.048 |
| R-HSA-418990 | Adherens junctions interactions | 1.250235e-01 | 0.903 |
| R-HSA-1280218 | Adaptive Immune System | 8.653818e-02 | 1.063 |
| R-HSA-421270 | Cell-cell junction organization | 1.735884e-01 | 0.760 |
| R-HSA-3000170 | Syndecan interactions | 2.074712e-01 | 0.683 |
| R-HSA-5688426 | Deubiquitination | 1.798762e-01 | 0.745 |
| R-HSA-5653656 | Vesicle-mediated transport | 2.209719e-01 | 0.656 |
| R-HSA-445355 | Smooth Muscle Contraction | 8.649488e-02 | 1.063 |
| R-HSA-446728 | Cell junction organization | 2.174128e-01 | 0.663 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 1.253081e-01 | 0.902 |
| R-HSA-6807070 | PTEN Regulation | 1.306447e-01 | 0.884 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 1.527563e-01 | 0.816 |
| R-HSA-168256 | Immune System | 8.039015e-02 | 1.095 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 1.546506e-01 | 0.811 |
| R-HSA-9020702 | Interleukin-1 signaling | 2.263690e-01 | 0.645 |
| R-HSA-168255 | Influenza Infection | 2.124068e-01 | 0.673 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 2.107301e-01 | 0.676 |
| R-HSA-75205 | Dissolution of Fibrin Clot | 1.061361e-01 | 0.974 |
| R-HSA-9682706 | Replication of the SARS-CoV-1 genome | 1.273823e-01 | 0.895 |
| R-HSA-9694686 | Replication of the SARS-CoV-2 genome | 1.616847e-01 | 0.791 |
| R-HSA-9734767 | Developmental Cell Lineages | 1.926773e-01 | 0.715 |
| R-HSA-9711123 | Cellular response to chemical stress | 2.008216e-01 | 0.697 |
| R-HSA-9679514 | SARS-CoV-1 Genome Replication and Transcription | 1.343524e-01 | 0.872 |
| R-HSA-1266695 | Interleukin-7 signaling | 2.200911e-01 | 0.657 |
| R-HSA-9694682 | SARS-CoV-2 Genome Replication and Transcription | 1.750279e-01 | 0.757 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 1.166127e-01 | 0.933 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 1.461557e-01 | 0.835 |
| R-HSA-112316 | Neuronal System | 9.902100e-02 | 1.004 |
| R-HSA-109581 | Apoptosis | 1.759564e-01 | 0.755 |
| R-HSA-449147 | Signaling by Interleukins | 1.480757e-01 | 0.830 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 2.312165e-01 | 0.636 |
| R-HSA-192823 | Viral mRNA Translation | 2.322531e-01 | 0.634 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 2.325116e-01 | 0.634 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 2.325116e-01 | 0.634 |
| R-HSA-264876 | Insulin processing | 2.325116e-01 | 0.634 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 2.351989e-01 | 0.629 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 2.351989e-01 | 0.629 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 2.386481e-01 | 0.622 |
| R-HSA-74160 | Gene expression (Transcription) | 2.412266e-01 | 0.618 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 2.447358e-01 | 0.611 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 2.447358e-01 | 0.611 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 2.470022e-01 | 0.607 |
| R-HSA-9700206 | Signaling by ALK in cancer | 2.470022e-01 | 0.607 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 2.470022e-01 | 0.607 |
| R-HSA-8953854 | Metabolism of RNA | 2.484454e-01 | 0.605 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 2.499570e-01 | 0.602 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 2.499570e-01 | 0.602 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 2.507753e-01 | 0.601 |
| R-HSA-68962 | Activation of the pre-replicative complex | 2.507753e-01 | 0.601 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 2.507753e-01 | 0.601 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 2.507753e-01 | 0.601 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 2.529129e-01 | 0.597 |
| R-HSA-389948 | Co-inhibition by PD-1 | 2.567457e-01 | 0.590 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 2.567668e-01 | 0.590 |
| R-HSA-2129379 | Molecules associated with elastic fibres | 2.567668e-01 | 0.590 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 2.567668e-01 | 0.590 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 2.627108e-01 | 0.581 |
| R-HSA-4791275 | Signaling by WNT in cancer | 2.627108e-01 | 0.581 |
| R-HSA-1538133 | G0 and Early G1 | 2.627108e-01 | 0.581 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 2.627108e-01 | 0.581 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 2.677024e-01 | 0.572 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 2.677024e-01 | 0.572 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 2.686076e-01 | 0.571 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 2.686076e-01 | 0.571 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 2.686076e-01 | 0.571 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 2.686076e-01 | 0.571 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 2.686076e-01 | 0.571 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 2.686076e-01 | 0.571 |
| R-HSA-9733709 | Cardiogenesis | 2.686076e-01 | 0.571 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 2.686076e-01 | 0.571 |
| R-HSA-5357801 | Programmed Cell Death | 2.696590e-01 | 0.569 |
| R-HSA-597592 | Post-translational protein modification | 2.699931e-01 | 0.569 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 2.706610e-01 | 0.568 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 2.744576e-01 | 0.562 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 2.744576e-01 | 0.562 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 2.744576e-01 | 0.562 |
| R-HSA-909733 | Interferon alpha/beta signaling | 2.765773e-01 | 0.558 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 2.765773e-01 | 0.558 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 2.795346e-01 | 0.554 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 2.795346e-01 | 0.554 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 2.802612e-01 | 0.552 |
| R-HSA-5673000 | RAF activation | 2.802612e-01 | 0.552 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 2.802612e-01 | 0.552 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 2.802612e-01 | 0.552 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 2.802612e-01 | 0.552 |
| R-HSA-1592230 | Mitochondrial biogenesis | 2.824912e-01 | 0.549 |
| R-HSA-1500931 | Cell-Cell communication | 2.833438e-01 | 0.548 |
| R-HSA-397014 | Muscle contraction | 2.848170e-01 | 0.545 |
| R-HSA-5693538 | Homology Directed Repair | 2.854469e-01 | 0.544 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 2.860188e-01 | 0.544 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 2.860188e-01 | 0.544 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 2.860188e-01 | 0.544 |
| R-HSA-169911 | Regulation of Apoptosis | 2.860188e-01 | 0.544 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 2.869890e-01 | 0.542 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 2.884014e-01 | 0.540 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 2.917306e-01 | 0.535 |
| R-HSA-74158 | RNA Polymerase III Transcription | 2.917306e-01 | 0.535 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 2.917306e-01 | 0.535 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 2.917306e-01 | 0.535 |
| R-HSA-8941326 | RUNX2 regulates bone development | 2.917306e-01 | 0.535 |
| R-HSA-3371511 | HSF1 activation | 2.917306e-01 | 0.535 |
| R-HSA-111933 | Calmodulin induced events | 2.917306e-01 | 0.535 |
| R-HSA-111997 | CaM pathway | 2.917306e-01 | 0.535 |
| R-HSA-69205 | G1/S-Specific Transcription | 2.917306e-01 | 0.535 |
| R-HSA-8853659 | RET signaling | 2.917306e-01 | 0.535 |
| R-HSA-72766 | Translation | 2.934093e-01 | 0.533 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 2.943065e-01 | 0.531 |
| R-HSA-5663205 | Infectious disease | 2.954613e-01 | 0.529 |
| R-HSA-4641258 | Degradation of DVL | 2.973971e-01 | 0.527 |
| R-HSA-4641257 | Degradation of AXIN | 2.973971e-01 | 0.527 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 2.973971e-01 | 0.527 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 2.973971e-01 | 0.527 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 2.973971e-01 | 0.527 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 2.973971e-01 | 0.527 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 2.973971e-01 | 0.527 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 3.002051e-01 | 0.523 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 3.030185e-01 | 0.519 |
| R-HSA-1566948 | Elastic fibre formation | 3.030185e-01 | 0.519 |
| R-HSA-8951664 | Neddylation | 3.044087e-01 | 0.517 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 3.085954e-01 | 0.511 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 3.085954e-01 | 0.511 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 3.085954e-01 | 0.511 |
| R-HSA-69541 | Stabilization of p53 | 3.085954e-01 | 0.511 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 3.090382e-01 | 0.510 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 3.090382e-01 | 0.510 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 3.090382e-01 | 0.510 |
| R-HSA-194138 | Signaling by VEGF | 3.090382e-01 | 0.510 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 3.141280e-01 | 0.503 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 3.141280e-01 | 0.503 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 3.196166e-01 | 0.495 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 3.196166e-01 | 0.495 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 3.196166e-01 | 0.495 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 3.196166e-01 | 0.495 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 3.250617e-01 | 0.488 |
| R-HSA-5674135 | MAP2K and MAPK activation | 3.250617e-01 | 0.488 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 3.250617e-01 | 0.488 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 3.250617e-01 | 0.488 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 3.250617e-01 | 0.488 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 3.250617e-01 | 0.488 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 3.250617e-01 | 0.488 |
| R-HSA-72312 | rRNA processing | 3.284343e-01 | 0.484 |
| R-HSA-9843745 | Adipogenesis | 3.295583e-01 | 0.482 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 3.301010e-01 | 0.481 |
| R-HSA-111996 | Ca-dependent events | 3.304635e-01 | 0.481 |
| R-HSA-9909396 | Circadian clock | 3.324773e-01 | 0.478 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 3.358224e-01 | 0.474 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 3.358224e-01 | 0.474 |
| R-HSA-1433557 | Signaling by SCF-KIT | 3.358224e-01 | 0.474 |
| R-HSA-8939211 | ESR-mediated signaling | 3.393597e-01 | 0.469 |
| R-HSA-9907900 | Proteasome assembly | 3.411388e-01 | 0.467 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 3.411388e-01 | 0.467 |
| R-HSA-373752 | Netrin-1 signaling | 3.411388e-01 | 0.467 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 3.464129e-01 | 0.460 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 3.464129e-01 | 0.460 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 3.464129e-01 | 0.460 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 3.464129e-01 | 0.460 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 3.464129e-01 | 0.460 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 3.464129e-01 | 0.460 |
| R-HSA-1489509 | DAG and IP3 signaling | 3.464129e-01 | 0.460 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 3.464129e-01 | 0.460 |
| R-HSA-9824272 | Somitogenesis | 3.464129e-01 | 0.460 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 3.516452e-01 | 0.454 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 3.516452e-01 | 0.454 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 3.516452e-01 | 0.454 |
| R-HSA-6802949 | Signaling by RAS mutants | 3.516452e-01 | 0.454 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 3.516452e-01 | 0.454 |
| R-HSA-9675135 | Diseases of DNA repair | 3.516452e-01 | 0.454 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 3.516452e-01 | 0.454 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 3.516452e-01 | 0.454 |
| R-HSA-9839373 | Signaling by TGFBR3 | 3.516452e-01 | 0.454 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 3.516452e-01 | 0.454 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 3.568358e-01 | 0.448 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 3.568358e-01 | 0.448 |
| R-HSA-8963899 | Plasma lipoprotein remodeling | 3.619853e-01 | 0.441 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 3.619853e-01 | 0.441 |
| R-HSA-9766229 | Degradation of CDH1 | 3.670938e-01 | 0.435 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 3.670938e-01 | 0.435 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 3.670938e-01 | 0.435 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 3.721617e-01 | 0.429 |
| R-HSA-912446 | Meiotic recombination | 3.771894e-01 | 0.423 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 3.771894e-01 | 0.423 |
| R-HSA-2514856 | The phototransduction cascade | 3.771894e-01 | 0.423 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 3.807234e-01 | 0.419 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 3.821771e-01 | 0.418 |
| R-HSA-68949 | Orc1 removal from chromatin | 3.821771e-01 | 0.418 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 3.821771e-01 | 0.418 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 3.871252e-01 | 0.412 |
| R-HSA-1221632 | Meiotic synapsis | 3.871252e-01 | 0.412 |
| R-HSA-8956320 | Nucleotide biosynthesis | 3.871252e-01 | 0.412 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 3.871252e-01 | 0.412 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 3.920340e-01 | 0.407 |
| R-HSA-446652 | Interleukin-1 family signaling | 3.955980e-01 | 0.403 |
| R-HSA-69306 | DNA Replication | 3.984073e-01 | 0.400 |
| R-HSA-193648 | NRAGE signals death through JNK | 4.017347e-01 | 0.396 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 4.017347e-01 | 0.396 |
| R-HSA-5578775 | Ion homeostasis | 4.017347e-01 | 0.396 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 4.017347e-01 | 0.396 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 4.017347e-01 | 0.396 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 4.040081e-01 | 0.394 |
| R-HSA-9764561 | Regulation of CDH1 Function | 4.065274e-01 | 0.391 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 4.112819e-01 | 0.386 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 4.112819e-01 | 0.386 |
| R-HSA-9711097 | Cellular response to starvation | 4.123630e-01 | 0.385 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 4.123630e-01 | 0.385 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 4.159987e-01 | 0.381 |
| R-HSA-9006936 | Signaling by TGFB family members | 4.179013e-01 | 0.379 |
| R-HSA-5633007 | Regulation of TP53 Activity | 4.179013e-01 | 0.379 |
| R-HSA-351202 | Metabolism of polyamines | 4.206779e-01 | 0.376 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 4.206779e-01 | 0.376 |
| R-HSA-1227986 | Signaling by ERBB2 | 4.206779e-01 | 0.376 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 4.253199e-01 | 0.371 |
| R-HSA-112043 | PLC beta mediated events | 4.253199e-01 | 0.371 |
| R-HSA-445717 | Aquaporin-mediated transport | 4.253199e-01 | 0.371 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 4.253199e-01 | 0.371 |
| R-HSA-2408522 | Selenoamino acid metabolism | 4.288992e-01 | 0.368 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 4.293270e-01 | 0.367 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 4.299251e-01 | 0.367 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 4.299251e-01 | 0.367 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 4.344936e-01 | 0.362 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 4.344936e-01 | 0.362 |
| R-HSA-936837 | Ion transport by P-type ATPases | 4.390257e-01 | 0.358 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 4.435219e-01 | 0.353 |
| R-HSA-1234174 | Cellular response to hypoxia | 4.435219e-01 | 0.353 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 4.505650e-01 | 0.346 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 4.524072e-01 | 0.344 |
| R-HSA-112040 | G-protein mediated events | 4.524072e-01 | 0.344 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 4.524072e-01 | 0.344 |
| R-HSA-5689880 | Ub-specific processing proteases | 4.559098e-01 | 0.341 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 4.567969e-01 | 0.340 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 4.567969e-01 | 0.340 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 4.635049e-01 | 0.334 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 4.654718e-01 | 0.332 |
| R-HSA-5632684 | Hedgehog 'on' state | 4.697576e-01 | 0.328 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 4.740092e-01 | 0.324 |
| R-HSA-2559583 | Cellular Senescence | 4.743811e-01 | 0.324 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 4.782271e-01 | 0.320 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 4.782271e-01 | 0.320 |
| R-HSA-4086398 | Ca2+ pathway | 4.782271e-01 | 0.320 |
| R-HSA-9013694 | Signaling by NOTCH4 | 4.824113e-01 | 0.317 |
| R-HSA-392499 | Metabolism of proteins | 4.852302e-01 | 0.314 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 4.865623e-01 | 0.313 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 4.865623e-01 | 0.313 |
| R-HSA-5689603 | UCH proteinases | 4.906803e-01 | 0.309 |
| R-HSA-212436 | Generic Transcription Pathway | 4.959318e-01 | 0.305 |
| R-HSA-983712 | Ion channel transport | 4.975715e-01 | 0.303 |
| R-HSA-416482 | G alpha (12/13) signalling events | 4.988181e-01 | 0.302 |
| R-HSA-5619084 | ABC transporter disorders | 4.988181e-01 | 0.302 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 5.028385e-01 | 0.299 |
| R-HSA-9659379 | Sensory processing of sound | 5.028385e-01 | 0.299 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 5.051575e-01 | 0.297 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 5.101739e-01 | 0.292 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 5.186026e-01 | 0.285 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 5.262977e-01 | 0.279 |
| R-HSA-1500620 | Meiosis | 5.262977e-01 | 0.279 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 5.262977e-01 | 0.279 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 5.300993e-01 | 0.276 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 5.338706e-01 | 0.273 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 5.338706e-01 | 0.273 |
| R-HSA-1474244 | Extracellular matrix organization | 5.354892e-01 | 0.271 |
| R-HSA-72172 | mRNA Splicing | 5.371691e-01 | 0.270 |
| R-HSA-70268 | Pyruvate metabolism | 5.376119e-01 | 0.270 |
| R-HSA-1236974 | ER-Phagosome pathway | 5.450054e-01 | 0.264 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 5.481603e-01 | 0.261 |
| R-HSA-202424 | Downstream TCR signaling | 5.486580e-01 | 0.261 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 5.594422e-01 | 0.252 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 5.629798e-01 | 0.250 |
| R-HSA-9837999 | Mitochondrial protein degradation | 5.664893e-01 | 0.247 |
| R-HSA-1474290 | Collagen formation | 5.664893e-01 | 0.247 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 5.694081e-01 | 0.245 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 5.734244e-01 | 0.242 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 5.768506e-01 | 0.239 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 5.802495e-01 | 0.236 |
| R-HSA-422356 | Regulation of insulin secretion | 5.836213e-01 | 0.234 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 5.836213e-01 | 0.234 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 5.836213e-01 | 0.234 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 5.836213e-01 | 0.234 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 5.869662e-01 | 0.231 |
| R-HSA-73894 | DNA Repair | 5.893826e-01 | 0.230 |
| R-HSA-382556 | ABC-family proteins mediated transport | 5.902844e-01 | 0.229 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 5.924715e-01 | 0.227 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 5.947276e-01 | 0.226 |
| R-HSA-111885 | Opioid Signalling | 6.032950e-01 | 0.219 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 6.064830e-01 | 0.217 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 6.064830e-01 | 0.217 |
| R-HSA-9833110 | RSV-host interactions | 6.064830e-01 | 0.217 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 6.096456e-01 | 0.215 |
| R-HSA-69239 | Synthesis of DNA | 6.158954e-01 | 0.210 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 6.189830e-01 | 0.208 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 6.189830e-01 | 0.208 |
| R-HSA-2672351 | Stimuli-sensing channels | 6.189830e-01 | 0.208 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 6.220459e-01 | 0.206 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 6.250844e-01 | 0.204 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 6.250844e-01 | 0.204 |
| R-HSA-202403 | TCR signaling | 6.250844e-01 | 0.204 |
| R-HSA-73857 | RNA Polymerase II Transcription | 6.254573e-01 | 0.204 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 6.340553e-01 | 0.198 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 6.428131e-01 | 0.192 |
| R-HSA-168249 | Innate Immune System | 6.480234e-01 | 0.188 |
| R-HSA-2980736 | Peptide hormone metabolism | 6.513629e-01 | 0.186 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 6.569496e-01 | 0.182 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 6.569496e-01 | 0.182 |
| R-HSA-3371556 | Cellular response to heat stress | 6.624475e-01 | 0.179 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 6.651636e-01 | 0.177 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 6.651636e-01 | 0.177 |
| R-HSA-416476 | G alpha (q) signalling events | 6.660158e-01 | 0.177 |
| R-HSA-6809371 | Formation of the cornified envelope | 6.705308e-01 | 0.174 |
| R-HSA-162909 | Host Interactions of HIV factors | 6.705308e-01 | 0.174 |
| R-HSA-114608 | Platelet degranulation | 6.810106e-01 | 0.167 |
| R-HSA-1474165 | Reproduction | 6.911594e-01 | 0.160 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 6.933792e-01 | 0.159 |
| R-HSA-5576891 | Cardiac conduction | 6.936462e-01 | 0.159 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 6.986268e-01 | 0.156 |
| R-HSA-1643685 | Disease | 7.008723e-01 | 0.154 |
| R-HSA-163685 | Integration of energy metabolism | 7.081549e-01 | 0.150 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 7.105058e-01 | 0.148 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 7.105850e-01 | 0.148 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 7.221477e-01 | 0.141 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 7.286492e-01 | 0.137 |
| R-HSA-2187338 | Visual phototransduction | 7.351580e-01 | 0.134 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 7.372930e-01 | 0.132 |
| R-HSA-9758941 | Gastrulation | 7.394110e-01 | 0.131 |
| R-HSA-73887 | Death Receptor Signaling | 7.497491e-01 | 0.125 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 7.515456e-01 | 0.124 |
| R-HSA-1989781 | PPARA activates gene expression | 7.517674e-01 | 0.124 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 7.557556e-01 | 0.122 |
| R-HSA-388396 | GPCR downstream signalling | 7.683015e-01 | 0.114 |
| R-HSA-418555 | G alpha (s) signalling events | 7.837083e-01 | 0.106 |
| R-HSA-5683057 | MAPK family signaling cascades | 7.951741e-01 | 0.100 |
| R-HSA-375276 | Peptide ligand-binding receptors | 8.084839e-01 | 0.092 |
| R-HSA-168898 | Toll-like Receptor Cascades | 8.160996e-01 | 0.088 |
| R-HSA-382551 | Transport of small molecules | 8.199780e-01 | 0.086 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 8.331732e-01 | 0.079 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 8.370839e-01 | 0.077 |
| R-HSA-372790 | Signaling by GPCR | 8.376348e-01 | 0.077 |
| R-HSA-6805567 | Keratinization | 8.385072e-01 | 0.076 |
| R-HSA-418594 | G alpha (i) signalling events | 8.599908e-01 | 0.066 |
| R-HSA-162906 | HIV Infection | 8.638546e-01 | 0.064 |
| R-HSA-15869 | Metabolism of nucleotides | 8.734698e-01 | 0.059 |
| R-HSA-157118 | Signaling by NOTCH | 8.775239e-01 | 0.057 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 8.843109e-01 | 0.053 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 8.899076e-01 | 0.051 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 9.101508e-01 | 0.041 |
| R-HSA-8957322 | Metabolism of steroids | 9.383092e-01 | 0.028 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.463275e-01 | 0.024 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.655458e-01 | 0.015 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.663855e-01 | 0.015 |
| R-HSA-211859 | Biological oxidations | 9.881243e-01 | 0.005 |
| R-HSA-500792 | GPCR ligand binding | 9.931371e-01 | 0.003 |
| R-HSA-9709957 | Sensory Perception | 9.996692e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.999969e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.839 | 0.128 | 2 | 0.883 |
CLK3 |
0.837 | 0.213 | 1 | 0.758 |
PIM3 |
0.835 | 0.222 | -3 | 0.786 |
KIS |
0.828 | 0.153 | 1 | 0.699 |
PIM1 |
0.826 | 0.225 | -3 | 0.734 |
MTOR |
0.826 | 0.007 | 1 | 0.700 |
NDR2 |
0.826 | 0.095 | -3 | 0.788 |
CDC7 |
0.825 | -0.024 | 1 | 0.692 |
MOS |
0.824 | 0.056 | 1 | 0.753 |
HIPK4 |
0.823 | 0.125 | 1 | 0.734 |
NLK |
0.823 | 0.093 | 1 | 0.768 |
PRPK |
0.823 | -0.030 | -1 | 0.901 |
ERK5 |
0.823 | 0.098 | 1 | 0.781 |
ATR |
0.822 | 0.034 | 1 | 0.728 |
GCN2 |
0.822 | -0.075 | 2 | 0.769 |
CDKL1 |
0.821 | 0.084 | -3 | 0.762 |
NDR1 |
0.821 | 0.138 | -3 | 0.786 |
SRPK1 |
0.821 | 0.095 | -3 | 0.708 |
CDKL5 |
0.821 | 0.124 | -3 | 0.750 |
DSTYK |
0.820 | 0.006 | 2 | 0.885 |
WNK1 |
0.820 | 0.109 | -2 | 0.879 |
RAF1 |
0.820 | -0.026 | 1 | 0.696 |
IKKB |
0.820 | -0.091 | -2 | 0.779 |
CDK8 |
0.820 | 0.110 | 1 | 0.661 |
CAMK1B |
0.819 | 0.027 | -3 | 0.836 |
CAMK2G |
0.819 | -0.014 | 2 | 0.843 |
TBK1 |
0.818 | -0.057 | 1 | 0.602 |
ICK |
0.818 | 0.137 | -3 | 0.797 |
DYRK2 |
0.817 | 0.118 | 1 | 0.701 |
PDHK4 |
0.817 | -0.165 | 1 | 0.715 |
FAM20C |
0.816 | 0.192 | 2 | 0.774 |
CDK19 |
0.815 | 0.114 | 1 | 0.640 |
RSK2 |
0.815 | 0.067 | -3 | 0.728 |
NUAK2 |
0.814 | 0.046 | -3 | 0.807 |
BMPR2 |
0.814 | -0.107 | -2 | 0.873 |
CDK1 |
0.813 | 0.128 | 1 | 0.632 |
PRKD1 |
0.813 | 0.009 | -3 | 0.772 |
CDK18 |
0.813 | 0.151 | 1 | 0.648 |
SKMLCK |
0.813 | 0.050 | -2 | 0.844 |
ULK2 |
0.812 | -0.112 | 2 | 0.754 |
RIPK3 |
0.812 | -0.003 | 3 | 0.690 |
IKKE |
0.812 | -0.122 | 1 | 0.588 |
JNK2 |
0.812 | 0.138 | 1 | 0.627 |
MARK4 |
0.812 | 0.045 | 4 | 0.825 |
CDK7 |
0.812 | 0.108 | 1 | 0.685 |
CLK2 |
0.811 | 0.157 | -3 | 0.709 |
P38B |
0.811 | 0.153 | 1 | 0.655 |
NIK |
0.811 | 0.020 | -3 | 0.854 |
CAMK2D |
0.811 | -0.008 | -3 | 0.807 |
P38A |
0.811 | 0.165 | 1 | 0.723 |
GRK1 |
0.810 | -0.001 | -2 | 0.848 |
MST4 |
0.810 | 0.035 | 2 | 0.786 |
CAMLCK |
0.810 | 0.020 | -2 | 0.830 |
P90RSK |
0.809 | 0.032 | -3 | 0.728 |
P70S6KB |
0.809 | 0.062 | -3 | 0.759 |
PRKD2 |
0.809 | 0.030 | -3 | 0.722 |
PIM2 |
0.809 | 0.207 | -3 | 0.706 |
PDHK1 |
0.808 | -0.211 | 1 | 0.702 |
PKN3 |
0.808 | -0.024 | -3 | 0.788 |
CDK5 |
0.808 | 0.127 | 1 | 0.711 |
AMPKA1 |
0.808 | 0.038 | -3 | 0.813 |
HIPK2 |
0.807 | 0.130 | 1 | 0.640 |
MASTL |
0.807 | -0.082 | -2 | 0.852 |
RSK3 |
0.807 | 0.032 | -3 | 0.719 |
LATS2 |
0.807 | -0.002 | -5 | 0.592 |
SRPK2 |
0.807 | 0.055 | -3 | 0.628 |
DYRK4 |
0.806 | 0.126 | 1 | 0.648 |
HUNK |
0.806 | -0.076 | 2 | 0.810 |
CAMK2B |
0.806 | 0.031 | 2 | 0.856 |
GRK5 |
0.806 | -0.144 | -3 | 0.846 |
PKACG |
0.806 | 0.040 | -2 | 0.695 |
CLK4 |
0.806 | 0.085 | -3 | 0.731 |
CDK3 |
0.806 | 0.141 | 1 | 0.611 |
CDK17 |
0.806 | 0.119 | 1 | 0.590 |
MLK1 |
0.806 | -0.114 | 2 | 0.769 |
TGFBR2 |
0.805 | -0.060 | -2 | 0.776 |
DAPK2 |
0.805 | -0.018 | -3 | 0.839 |
NEK6 |
0.805 | -0.081 | -2 | 0.815 |
DNAPK |
0.805 | 0.059 | 1 | 0.630 |
IKKA |
0.805 | -0.071 | -2 | 0.768 |
CDK2 |
0.805 | 0.099 | 1 | 0.693 |
ERK1 |
0.805 | 0.113 | 1 | 0.655 |
WNK3 |
0.805 | -0.088 | 1 | 0.700 |
AURC |
0.805 | 0.086 | -2 | 0.606 |
CHAK2 |
0.805 | -0.043 | -1 | 0.864 |
MAPKAPK2 |
0.804 | 0.001 | -3 | 0.670 |
MAPKAPK3 |
0.804 | -0.032 | -3 | 0.726 |
ATM |
0.804 | -0.014 | 1 | 0.675 |
HIPK1 |
0.804 | 0.128 | 1 | 0.721 |
JNK3 |
0.804 | 0.087 | 1 | 0.656 |
NEK7 |
0.804 | -0.150 | -3 | 0.833 |
CLK1 |
0.804 | 0.090 | -3 | 0.711 |
PAK1 |
0.803 | 0.044 | -2 | 0.785 |
PKN2 |
0.803 | -0.022 | -3 | 0.806 |
CDK13 |
0.803 | 0.058 | 1 | 0.664 |
P38G |
0.803 | 0.111 | 1 | 0.579 |
MPSK1 |
0.803 | 0.331 | 1 | 0.824 |
SRPK3 |
0.803 | 0.026 | -3 | 0.684 |
P38D |
0.803 | 0.137 | 1 | 0.629 |
NIM1 |
0.802 | 0.002 | 3 | 0.713 |
PKCD |
0.802 | 0.006 | 2 | 0.738 |
MLK2 |
0.802 | -0.041 | 2 | 0.784 |
AMPKA2 |
0.802 | 0.027 | -3 | 0.777 |
RSK4 |
0.802 | 0.081 | -3 | 0.689 |
CDK16 |
0.802 | 0.169 | 1 | 0.609 |
BMPR1B |
0.802 | 0.035 | 1 | 0.632 |
TSSK2 |
0.801 | -0.043 | -5 | 0.632 |
GRK6 |
0.801 | -0.103 | 1 | 0.675 |
ULK1 |
0.800 | -0.167 | -3 | 0.816 |
IRE1 |
0.800 | -0.013 | 1 | 0.716 |
RIPK1 |
0.800 | -0.097 | 1 | 0.709 |
PAK3 |
0.800 | 0.007 | -2 | 0.785 |
TGFBR1 |
0.800 | 0.003 | -2 | 0.808 |
GRK4 |
0.799 | -0.115 | -2 | 0.835 |
BCKDK |
0.799 | -0.161 | -1 | 0.817 |
CDK9 |
0.799 | 0.062 | 1 | 0.677 |
ALK4 |
0.799 | -0.022 | -2 | 0.831 |
CAMK2A |
0.799 | 0.003 | 2 | 0.846 |
SMG1 |
0.798 | -0.019 | 1 | 0.695 |
DYRK1B |
0.798 | 0.114 | 1 | 0.677 |
CDK14 |
0.798 | 0.137 | 1 | 0.681 |
TSSK1 |
0.798 | -0.013 | -3 | 0.833 |
GAK |
0.798 | 0.427 | 1 | 0.884 |
PKR |
0.797 | 0.018 | 1 | 0.746 |
CDK10 |
0.797 | 0.149 | 1 | 0.675 |
DLK |
0.797 | -0.173 | 1 | 0.672 |
ANKRD3 |
0.797 | -0.115 | 1 | 0.747 |
HIPK3 |
0.797 | 0.091 | 1 | 0.716 |
NEK9 |
0.797 | -0.141 | 2 | 0.784 |
PAK6 |
0.796 | 0.039 | -2 | 0.702 |
PKACB |
0.796 | 0.071 | -2 | 0.615 |
DYRK1A |
0.796 | 0.084 | 1 | 0.717 |
MELK |
0.796 | 0.015 | -3 | 0.766 |
CAMK4 |
0.796 | -0.061 | -3 | 0.786 |
MEK1 |
0.796 | -0.089 | 2 | 0.842 |
GRK7 |
0.796 | 0.004 | 1 | 0.648 |
TTBK2 |
0.795 | -0.149 | 2 | 0.689 |
ERK2 |
0.795 | 0.067 | 1 | 0.664 |
QIK |
0.795 | -0.024 | -3 | 0.808 |
CDK12 |
0.795 | 0.049 | 1 | 0.636 |
MYLK4 |
0.795 | 0.021 | -2 | 0.747 |
MLK3 |
0.795 | -0.056 | 2 | 0.691 |
PAK2 |
0.794 | 0.004 | -2 | 0.781 |
PRKD3 |
0.794 | -0.017 | -3 | 0.709 |
QSK |
0.793 | -0.000 | 4 | 0.810 |
MARK3 |
0.793 | 0.042 | 4 | 0.781 |
IRE2 |
0.793 | -0.005 | 2 | 0.681 |
MNK2 |
0.793 | -0.003 | -2 | 0.755 |
PRKX |
0.793 | 0.078 | -3 | 0.626 |
NUAK1 |
0.793 | -0.021 | -3 | 0.752 |
MSK2 |
0.793 | -0.040 | -3 | 0.689 |
LATS1 |
0.793 | 0.010 | -3 | 0.803 |
DYRK3 |
0.793 | 0.079 | 1 | 0.720 |
PRP4 |
0.792 | 0.047 | -3 | 0.719 |
ALK2 |
0.792 | -0.001 | -2 | 0.811 |
PKCG |
0.792 | -0.020 | 2 | 0.687 |
AURB |
0.792 | 0.039 | -2 | 0.608 |
SIK |
0.791 | -0.003 | -3 | 0.724 |
PKCB |
0.791 | -0.011 | 2 | 0.681 |
PLK3 |
0.791 | -0.062 | 2 | 0.809 |
PKCA |
0.791 | -0.018 | 2 | 0.664 |
MARK2 |
0.791 | 0.015 | 4 | 0.749 |
VRK2 |
0.790 | -0.140 | 1 | 0.766 |
PKCZ |
0.790 | -0.021 | 2 | 0.727 |
MSK1 |
0.790 | -0.004 | -3 | 0.696 |
YSK4 |
0.790 | -0.133 | 1 | 0.633 |
BRSK2 |
0.790 | -0.034 | -3 | 0.781 |
SGK3 |
0.790 | 0.031 | -3 | 0.712 |
AKT2 |
0.789 | 0.031 | -3 | 0.649 |
MNK1 |
0.789 | 0.009 | -2 | 0.754 |
CAMK1G |
0.789 | 0.001 | -3 | 0.733 |
PINK1 |
0.788 | -0.030 | 1 | 0.784 |
CHK1 |
0.788 | -0.046 | -3 | 0.766 |
ACVR2A |
0.788 | -0.072 | -2 | 0.771 |
BRSK1 |
0.788 | -0.044 | -3 | 0.750 |
PHKG1 |
0.788 | -0.049 | -3 | 0.783 |
MAK |
0.788 | 0.191 | -2 | 0.813 |
CK1E |
0.788 | 0.029 | -3 | 0.568 |
PBK |
0.788 | 0.406 | 1 | 0.903 |
PLK1 |
0.788 | -0.144 | -2 | 0.770 |
PKG2 |
0.787 | 0.019 | -2 | 0.607 |
MARK1 |
0.787 | -0.003 | 4 | 0.789 |
ACVR2B |
0.786 | -0.078 | -2 | 0.779 |
PASK |
0.786 | 0.048 | -3 | 0.805 |
PKCH |
0.786 | -0.052 | 2 | 0.665 |
CDK6 |
0.786 | 0.113 | 1 | 0.680 |
CHAK1 |
0.786 | -0.123 | 2 | 0.731 |
NEK2 |
0.785 | -0.112 | 2 | 0.751 |
DRAK1 |
0.785 | -0.061 | 1 | 0.627 |
TLK2 |
0.785 | -0.118 | 1 | 0.652 |
DCAMKL1 |
0.785 | 0.018 | -3 | 0.741 |
JNK1 |
0.785 | 0.067 | 1 | 0.618 |
WNK4 |
0.785 | -0.038 | -2 | 0.877 |
GSK3A |
0.785 | 0.047 | 4 | 0.417 |
MLK4 |
0.784 | -0.115 | 2 | 0.680 |
MOK |
0.784 | 0.159 | 1 | 0.750 |
BRAF |
0.784 | -0.064 | -4 | 0.761 |
PERK |
0.784 | -0.095 | -2 | 0.825 |
BMPR1A |
0.784 | -0.003 | 1 | 0.616 |
MST3 |
0.783 | 0.015 | 2 | 0.777 |
AURA |
0.783 | -0.009 | -2 | 0.586 |
MAPKAPK5 |
0.783 | -0.112 | -3 | 0.674 |
PLK4 |
0.783 | -0.092 | 2 | 0.625 |
GSK3B |
0.782 | 0.003 | 4 | 0.412 |
SNRK |
0.782 | -0.133 | 2 | 0.648 |
HRI |
0.782 | -0.114 | -2 | 0.831 |
GRK2 |
0.781 | -0.094 | -2 | 0.719 |
MEKK3 |
0.781 | -0.137 | 1 | 0.670 |
IRAK4 |
0.781 | -0.018 | 1 | 0.717 |
MEK5 |
0.781 | -0.173 | 2 | 0.800 |
CK1D |
0.781 | 0.023 | -3 | 0.525 |
P70S6K |
0.781 | 0.004 | -3 | 0.665 |
PKACA |
0.780 | 0.034 | -2 | 0.552 |
TAO3 |
0.779 | -0.030 | 1 | 0.671 |
SSTK |
0.779 | -0.007 | 4 | 0.787 |
NEK5 |
0.779 | -0.052 | 1 | 0.743 |
SMMLCK |
0.779 | -0.032 | -3 | 0.787 |
ERK7 |
0.778 | 0.018 | 2 | 0.478 |
PAK5 |
0.778 | 0.004 | -2 | 0.661 |
CK1G1 |
0.778 | -0.017 | -3 | 0.570 |
MEKK2 |
0.778 | -0.107 | 2 | 0.772 |
TLK1 |
0.778 | -0.123 | -2 | 0.807 |
ZAK |
0.778 | -0.140 | 1 | 0.636 |
DCAMKL2 |
0.777 | -0.022 | -3 | 0.775 |
CDK4 |
0.777 | 0.077 | 1 | 0.629 |
LKB1 |
0.777 | 0.028 | -3 | 0.812 |
MEKK1 |
0.776 | -0.176 | 1 | 0.692 |
AKT1 |
0.776 | 0.014 | -3 | 0.664 |
CK1A2 |
0.775 | 0.010 | -3 | 0.523 |
PKCI |
0.775 | -0.018 | 2 | 0.684 |
BIKE |
0.774 | 0.403 | 1 | 0.905 |
PHKG2 |
0.774 | -0.040 | -3 | 0.775 |
CAMK1D |
0.774 | -0.009 | -3 | 0.640 |
MRCKA |
0.774 | 0.124 | -3 | 0.712 |
CAMKK1 |
0.774 | -0.104 | -2 | 0.764 |
PAK4 |
0.773 | -0.006 | -2 | 0.661 |
CK2A2 |
0.773 | -0.022 | 1 | 0.562 |
PKCT |
0.773 | -0.053 | 2 | 0.673 |
TTBK1 |
0.773 | -0.146 | 2 | 0.618 |
DAPK3 |
0.772 | 0.024 | -3 | 0.762 |
PDK1 |
0.771 | -0.075 | 1 | 0.704 |
TAO2 |
0.771 | -0.061 | 2 | 0.797 |
IRAK1 |
0.771 | -0.145 | -1 | 0.783 |
GCK |
0.770 | -0.026 | 1 | 0.651 |
CAMKK2 |
0.770 | -0.102 | -2 | 0.758 |
MRCKB |
0.769 | 0.071 | -3 | 0.699 |
AKT3 |
0.769 | 0.042 | -3 | 0.574 |
PKCE |
0.769 | -0.011 | 2 | 0.660 |
DMPK1 |
0.769 | 0.150 | -3 | 0.725 |
SGK1 |
0.768 | 0.044 | -3 | 0.556 |
GRK3 |
0.768 | -0.088 | -2 | 0.679 |
NEK11 |
0.768 | -0.168 | 1 | 0.656 |
ROCK2 |
0.768 | 0.098 | -3 | 0.739 |
NEK4 |
0.767 | -0.082 | 1 | 0.680 |
EEF2K |
0.766 | -0.061 | 3 | 0.786 |
HPK1 |
0.766 | -0.025 | 1 | 0.632 |
NEK8 |
0.766 | -0.170 | 2 | 0.760 |
CK2A1 |
0.765 | -0.029 | 1 | 0.535 |
DAPK1 |
0.765 | -0.002 | -3 | 0.744 |
SBK |
0.765 | 0.012 | -3 | 0.527 |
TNIK |
0.765 | -0.026 | 3 | 0.828 |
MEKK6 |
0.765 | -0.065 | 1 | 0.671 |
AAK1 |
0.765 | 0.425 | 1 | 0.875 |
MINK |
0.764 | -0.078 | 1 | 0.651 |
TAK1 |
0.764 | -0.112 | 1 | 0.665 |
HGK |
0.764 | -0.068 | 3 | 0.822 |
LRRK2 |
0.764 | -0.102 | 2 | 0.799 |
STK33 |
0.764 | -0.084 | 2 | 0.620 |
PLK2 |
0.764 | -0.061 | -3 | 0.750 |
MST2 |
0.763 | -0.131 | 1 | 0.665 |
MAP3K15 |
0.763 | -0.105 | 1 | 0.643 |
NEK1 |
0.763 | -0.034 | 1 | 0.709 |
LOK |
0.762 | -0.023 | -2 | 0.770 |
PKN1 |
0.762 | -0.052 | -3 | 0.688 |
KHS1 |
0.761 | -0.025 | 1 | 0.640 |
VRK1 |
0.760 | -0.153 | 2 | 0.814 |
PDHK3_TYR |
0.759 | 0.138 | 4 | 0.831 |
KHS2 |
0.759 | -0.008 | 1 | 0.646 |
MST1 |
0.759 | -0.100 | 1 | 0.652 |
BUB1 |
0.758 | 0.008 | -5 | 0.555 |
CHK2 |
0.758 | -0.051 | -3 | 0.594 |
CAMK1A |
0.758 | -0.035 | -3 | 0.610 |
SLK |
0.757 | -0.061 | -2 | 0.739 |
MEK2 |
0.756 | -0.169 | 2 | 0.791 |
YSK1 |
0.754 | -0.084 | 2 | 0.739 |
MAP2K4_TYR |
0.754 | 0.068 | -1 | 0.913 |
CRIK |
0.753 | 0.044 | -3 | 0.653 |
ROCK1 |
0.753 | 0.056 | -3 | 0.708 |
PKMYT1_TYR |
0.752 | 0.108 | 3 | 0.811 |
PDHK4_TYR |
0.752 | 0.044 | 2 | 0.878 |
MAP2K6_TYR |
0.751 | 0.046 | -1 | 0.902 |
TESK1_TYR |
0.751 | 0.031 | 3 | 0.842 |
RIPK2 |
0.749 | -0.246 | 1 | 0.611 |
LIMK2_TYR |
0.749 | 0.099 | -3 | 0.861 |
ALPHAK3 |
0.748 | -0.030 | -1 | 0.803 |
NEK3 |
0.748 | -0.121 | 1 | 0.665 |
MAP2K7_TYR |
0.747 | -0.093 | 2 | 0.844 |
PDHK1_TYR |
0.747 | -0.013 | -1 | 0.905 |
OSR1 |
0.747 | -0.094 | 2 | 0.769 |
HASPIN |
0.746 | -0.036 | -1 | 0.708 |
YANK3 |
0.745 | -0.046 | 2 | 0.429 |
BMPR2_TYR |
0.745 | -0.035 | -1 | 0.873 |
PKG1 |
0.745 | -0.048 | -2 | 0.518 |
TTK |
0.743 | -0.074 | -2 | 0.795 |
MYO3B |
0.743 | -0.057 | 2 | 0.750 |
PINK1_TYR |
0.742 | -0.132 | 1 | 0.721 |
ASK1 |
0.740 | -0.153 | 1 | 0.624 |
CK1A |
0.740 | -0.032 | -3 | 0.440 |
YES1 |
0.739 | 0.104 | -1 | 0.878 |
MYO3A |
0.739 | -0.100 | 1 | 0.652 |
LIMK1_TYR |
0.738 | -0.061 | 2 | 0.817 |
ABL2 |
0.737 | 0.029 | -1 | 0.840 |
EPHA6 |
0.736 | -0.029 | -1 | 0.857 |
TXK |
0.736 | 0.038 | 1 | 0.688 |
FGR |
0.736 | 0.056 | 1 | 0.777 |
EPHB4 |
0.736 | -0.032 | -1 | 0.848 |
ABL1 |
0.735 | 0.034 | -1 | 0.835 |
RET |
0.735 | -0.110 | 1 | 0.686 |
TAO1 |
0.735 | -0.115 | 1 | 0.604 |
TNK2 |
0.734 | 0.019 | 3 | 0.692 |
BLK |
0.734 | 0.129 | -1 | 0.853 |
DDR1 |
0.733 | -0.100 | 4 | 0.749 |
EPHA4 |
0.733 | -0.021 | 2 | 0.810 |
MST1R |
0.732 | -0.139 | 3 | 0.747 |
LCK |
0.731 | 0.090 | -1 | 0.843 |
TYRO3 |
0.731 | -0.125 | 3 | 0.742 |
FYN |
0.730 | 0.103 | -1 | 0.824 |
HCK |
0.729 | 0.009 | -1 | 0.851 |
CSF1R |
0.729 | -0.133 | 3 | 0.739 |
JAK2 |
0.729 | -0.195 | 1 | 0.678 |
TYK2 |
0.729 | -0.237 | 1 | 0.684 |
SRMS |
0.728 | -0.073 | 1 | 0.690 |
ITK |
0.728 | -0.038 | -1 | 0.825 |
ROS1 |
0.728 | -0.160 | 3 | 0.706 |
FER |
0.726 | -0.129 | 1 | 0.736 |
EPHB2 |
0.726 | -0.041 | -1 | 0.819 |
STLK3 |
0.725 | -0.198 | 1 | 0.601 |
INSRR |
0.725 | -0.102 | 3 | 0.687 |
JAK3 |
0.725 | -0.147 | 1 | 0.661 |
EPHB3 |
0.725 | -0.062 | -1 | 0.830 |
TNNI3K_TYR |
0.724 | -0.056 | 1 | 0.697 |
NEK10_TYR |
0.723 | -0.104 | 1 | 0.557 |
EPHB1 |
0.723 | -0.120 | 1 | 0.685 |
FGFR2 |
0.722 | -0.137 | 3 | 0.739 |
TNK1 |
0.721 | -0.071 | 3 | 0.720 |
KIT |
0.721 | -0.151 | 3 | 0.741 |
TEK |
0.720 | -0.137 | 3 | 0.674 |
MERTK |
0.720 | -0.098 | 3 | 0.718 |
LYN |
0.719 | 0.000 | 3 | 0.654 |
BMX |
0.719 | -0.061 | -1 | 0.757 |
AXL |
0.719 | -0.134 | 3 | 0.713 |
MET |
0.718 | -0.104 | 3 | 0.724 |
KDR |
0.718 | -0.118 | 3 | 0.692 |
TEC |
0.718 | -0.091 | -1 | 0.794 |
CK1G3 |
0.718 | -0.047 | -3 | 0.397 |
JAK1 |
0.718 | -0.143 | 1 | 0.627 |
SRC |
0.717 | 0.037 | -1 | 0.830 |
PDGFRB |
0.717 | -0.208 | 3 | 0.737 |
YANK2 |
0.717 | -0.056 | 2 | 0.452 |
FGFR1 |
0.716 | -0.184 | 3 | 0.698 |
WEE1_TYR |
0.716 | -0.100 | -1 | 0.790 |
PTK2B |
0.715 | -0.041 | -1 | 0.818 |
EPHA3 |
0.715 | -0.106 | 2 | 0.773 |
BTK |
0.715 | -0.154 | -1 | 0.802 |
FLT3 |
0.715 | -0.204 | 3 | 0.726 |
EPHA7 |
0.714 | -0.103 | 2 | 0.801 |
DDR2 |
0.714 | -0.045 | 3 | 0.680 |
FLT1 |
0.713 | -0.134 | -1 | 0.813 |
LTK |
0.713 | -0.134 | 3 | 0.684 |
ERBB2 |
0.712 | -0.171 | 1 | 0.633 |
PDGFRA |
0.710 | -0.257 | 3 | 0.742 |
FGFR3 |
0.709 | -0.163 | 3 | 0.709 |
EPHA5 |
0.709 | -0.086 | 2 | 0.805 |
PTK6 |
0.709 | -0.193 | -1 | 0.760 |
EPHA1 |
0.709 | -0.132 | 3 | 0.686 |
NTRK1 |
0.708 | -0.239 | -1 | 0.835 |
ALK |
0.708 | -0.195 | 3 | 0.652 |
FRK |
0.708 | -0.151 | -1 | 0.857 |
FLT4 |
0.706 | -0.202 | 3 | 0.705 |
PTK2 |
0.705 | -0.041 | -1 | 0.755 |
NTRK2 |
0.705 | -0.227 | 3 | 0.695 |
INSR |
0.705 | -0.180 | 3 | 0.664 |
CSK |
0.704 | -0.153 | 2 | 0.793 |
EPHA8 |
0.704 | -0.117 | -1 | 0.804 |
EGFR |
0.703 | -0.119 | 1 | 0.545 |
CK1G2 |
0.703 | -0.040 | -3 | 0.489 |
MATK |
0.703 | -0.134 | -1 | 0.758 |
NTRK3 |
0.702 | -0.191 | -1 | 0.786 |
FGFR4 |
0.702 | -0.126 | -1 | 0.780 |
SYK |
0.701 | -0.070 | -1 | 0.758 |
EPHA2 |
0.694 | -0.121 | -1 | 0.760 |
ERBB4 |
0.693 | -0.095 | 1 | 0.541 |
MUSK |
0.689 | -0.176 | 1 | 0.564 |
IGF1R |
0.689 | -0.188 | 3 | 0.605 |
ZAP70 |
0.682 | -0.059 | -1 | 0.695 |
FES |
0.678 | -0.181 | -1 | 0.735 |