Motif 811 (n=158)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A1W2PRB8 | None | S595 | ochoa | Cofactor required for Sp1 transcriptional activation subunit 6 | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000256|ARBA:ARBA00025687}. |
| A6NKT7 | RGPD3 | S1543 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| O00244 | ATOX1 | S44 | ochoa | Copper transport protein ATOX1 (Metal transport protein ATX1) | Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense. |
| O00512 | BCL9 | S35 | ochoa | B-cell CLL/lymphoma 9 protein (B-cell lymphoma 9 protein) (Bcl-9) (Protein legless homolog) | Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:11955446}. |
| O15511 | ARPC5 | S77 | psp | Actin-related protein 2/3 complex subunit 5 (Arp2/3 complex 16 kDa subunit) (p16-ARC) | Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). {ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:9230079}. |
| O43166 | SIPA1L1 | S1178 | ochoa | Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) | Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}. |
| O43504 | LAMTOR5 | S26 | ochoa|psp | Ragulator complex protein LAMTOR5 (Hepatitis B virus X-interacting protein) (HBV X-interacting protein) (HBX-interacting protein) (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5) | As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:22980980, PubMed:29158492, PubMed:30181260). Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane (PubMed:22980980, PubMed:28935770, PubMed:29107538, PubMed:29158492, PubMed:30181260). Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (PubMed:22980980, PubMed:29158492, PubMed:30181260). When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway (PubMed:12773388). {ECO:0000269|PubMed:12773388, ECO:0000269|PubMed:22980980, ECO:0000269|PubMed:28935770, ECO:0000269|PubMed:29107538, ECO:0000269|PubMed:29158492, ECO:0000269|PubMed:30181260}. |
| O60934 | NBN | S397 | ochoa|psp | Nibrin (Cell cycle regulatory protein p95) (Nijmegen breakage syndrome protein 1) (hNbs1) | Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:10888888, PubMed:15616588, PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:19759395, PubMed:23115235, PubMed:28216226, PubMed:28867292, PubMed:9705271). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (PubMed:19759395, PubMed:28867292, PubMed:9705271). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (PubMed:19759395, PubMed:9705271). The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination (PubMed:19759395, PubMed:28867292, PubMed:9705271). Within the MRN complex, NBN acts as a protein-protein adapter, which specifically recognizes and binds phosphorylated proteins, promoting their recruitment to DNA damage sites (PubMed:12419185, PubMed:15616588, PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890, PubMed:19759395, PubMed:19804756, PubMed:23762398, PubMed:24534091, PubMed:27814491, PubMed:27889449, PubMed:33836577). Recruits MRE11 and RAD50 components of the MRN complex to DSBs in response to DNA damage (PubMed:12419185, PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:24534091, PubMed:26438602). Promotes the recruitment of PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites, activating their functions (PubMed:15064416, PubMed:15616588, PubMed:15790808, PubMed:16622404, PubMed:22464731, PubMed:30952868, PubMed:35076389). Mediates the recruitment of phosphorylated RBBP8/CtIP to DSBs, leading to cooperation between the MRN complex and RBBP8/CtIP to initiate end resection (PubMed:19759395, PubMed:27814491, PubMed:27889449, PubMed:33836577). RBBP8/CtIP specifically promotes the endonuclease activity of the MRN complex to clear DNA ends containing protein adducts (PubMed:27814491, PubMed:27889449, PubMed:30787182, PubMed:33836577). The MRN complex is also required for the processing of R-loops (PubMed:31537797). NBN also functions in telomere length maintenance via its interaction with TERF2: interaction with TERF2 during G1 phase preventing recruitment of DCLRE1B/Apollo to telomeres (PubMed:10888888, PubMed:28216226). NBN also promotes DNA repair choice at dysfunctional telomeres: NBN phosphorylation by CDK2 promotes non-homologous end joining repair at telomeres, while unphosphorylated NBN promotes microhomology-mediated end-joining (MMEJ) repair (PubMed:28216226). Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex (PubMed:23762398). {ECO:0000269|PubMed:10888888, ECO:0000269|PubMed:12419185, ECO:0000269|PubMed:15064416, ECO:0000269|PubMed:15616588, ECO:0000269|PubMed:15790808, ECO:0000269|PubMed:16622404, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:19759395, ECO:0000269|PubMed:19804756, ECO:0000269|PubMed:22464731, ECO:0000269|PubMed:23115235, ECO:0000269|PubMed:23762398, ECO:0000269|PubMed:24534091, ECO:0000269|PubMed:26438602, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:28216226, ECO:0000269|PubMed:28867292, ECO:0000269|PubMed:30787182, ECO:0000269|PubMed:30952868, ECO:0000269|PubMed:31537797, ECO:0000269|PubMed:33836577, ECO:0000269|PubMed:35076389, ECO:0000269|PubMed:9705271}. |
| O75821 | EIF3G | S264 | ochoa | Eukaryotic translation initiation factor 3 subunit G (eIF3g) (Eukaryotic translation initiation factor 3 RNA-binding subunit) (eIF-3 RNA-binding subunit) (Eukaryotic translation initiation factor 3 subunit 4) (eIF-3-delta) (eIF3 p42) (eIF3 p44) | RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). This subunit can bind 18S rRNA. {ECO:0000255|HAMAP-Rule:MF_03006, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}. |
| O75891 | ALDH1L1 | S629 | ochoa | Cytosolic 10-formyltetrahydrofolate dehydrogenase (10-FTHFDH) (FDH) (EC 1.5.1.6) (Aldehyde dehydrogenase family 1 member L1) | Cytosolic 10-formyltetrahydrofolate dehydrogenase that catalyzes the NADP(+)-dependent conversion of 10-formyltetrahydrofolate to tetrahydrofolate and carbon dioxide (PubMed:19933275, PubMed:21238436). May also have an NADP(+)-dependent aldehyde dehydrogenase activity towards formaldehyde, acetaldehyde, propionaldehyde, and benzaldehyde (By similarity). {ECO:0000250|UniProtKB:P28037, ECO:0000269|PubMed:19933275, ECO:0000269|PubMed:21238436}. |
| O94804 | STK10 | S417 | ochoa | Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase) | Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. {ECO:0000269|PubMed:11903060, ECO:0000269|PubMed:12639966, ECO:0000269|PubMed:19255442}. |
| O94916 | NFAT5 | S229 | ochoa | Nuclear factor of activated T-cells 5 (NF-AT5) (T-cell transcription factor NFAT5) (Tonicity-responsive enhancer-binding protein) (TonE-binding protein) (TonEBP) | Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3' (PubMed:10377394). Mediates the transcriptional response to hypertonicity (PubMed:10051678). Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17 (PubMed:22266867). Also involved in the DNA damage response by preventing formation of R-loops; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:34049076). {ECO:0000269|PubMed:10051678, ECO:0000269|PubMed:10377394, ECO:0000269|PubMed:22266867, ECO:0000269|PubMed:34049076}. |
| O94967 | WDR47 | S326 | ochoa | WD repeat-containing protein 47 (Neuronal enriched MAP-interacting protein) (Nemitin) | None |
| O95340 | PAPSS2 | S26 | ochoa | Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 (PAPS synthase 2) (PAPSS 2) (Sulfurylase kinase 2) (SK 2) (SK2) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (ATP-sulfurylase) (Sulfate adenylate transferase) (SAT); Adenylyl-sulfate kinase (EC 2.7.1.25) (3'-phosphoadenosine-5'-phosphosulfate synthase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (Adenylylsulfate 3'-phosphotransferase)] | Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate/PAPS, the activated sulfate donor used by sulfotransferases (PubMed:11773860, PubMed:19474428, PubMed:23824674, PubMed:25594860). In mammals, PAPS is the sole source of sulfate while APS appears to only be an intermediate in the sulfate-activation pathway (PubMed:11773860, PubMed:19474428, PubMed:23824674, PubMed:25594860). Plays indirectly an important role in skeletogenesis during postnatal growth (PubMed:9771708). {ECO:0000269|PubMed:11773860, ECO:0000269|PubMed:19474428, ECO:0000269|PubMed:23824674, ECO:0000269|PubMed:25594860, ECO:0000269|PubMed:9771708}. |
| O95490 | ADGRL2 | S1275 | ochoa | Adhesion G protein-coupled receptor L2 (Calcium-independent alpha-latrotoxin receptor 2) (CIRL-2) (Latrophilin homolog 1) (Latrophilin-2) (Lectomedin-1) | Orphan adhesion G-protein coupled receptor (aGPCR), which mediates synapse specificity (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (By similarity). Following G-protein coupled receptor activation, associates with cell adhesion molecules that are expressed at the surface of adjacent cells to direct synapse specificity. Specifically mediates the establishment of perforant-path synapses on CA1-region pyramidal neurons in the hippocampus. Localizes to postsynaptic spines in excitatory synapses in the S.lacunosum-moleculare and interacts with presynaptic cell adhesion molecules, such as teneurins, promoting synapse formation (By similarity). {ECO:0000250|UniProtKB:Q80TS3, ECO:0000250|UniProtKB:Q8JZZ7}. |
| O95835 | LATS1 | S872 | psp | Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts) | Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:10518011, PubMed:10831611, PubMed:18158288, PubMed:26437443, PubMed:28068668). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288, PubMed:26437443, PubMed:28068668). Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:18158288, PubMed:26437443, PubMed:28068668). Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint (PubMed:15122335, PubMed:19927127). Negatively regulates G2/M transition by down-regulating CDK1 kinase activity (PubMed:9988268). Involved in the control of p53 expression (PubMed:15122335). Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1 (PubMed:15220930). May also play a role in endocrine function. Plays a role in mammary gland epithelial cell differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1 (PubMed:28068668). Acts as an activator of the NLRP3 inflammasome by mediating phosphorylation of 'Ser-265' of NLRP3 following NLRP3 palmitoylation, promoting NLRP3 activation by NEK7 (PubMed:39173637). {ECO:0000269|PubMed:10518011, ECO:0000269|PubMed:10831611, ECO:0000269|PubMed:15122335, ECO:0000269|PubMed:15220930, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:28068668, ECO:0000269|PubMed:39173637, ECO:0000269|PubMed:9988268}. |
| O96028 | NSD2 | S102 | ochoa|psp | Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein) | Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:19808676, PubMed:22099308, PubMed:27571355, PubMed:29728617, PubMed:33941880). Also monomethylates nucleosomal histone H3 at 'Lys-36' (H3K36me) in vitro (PubMed:22099308). Does not trimethylate nucleosomal histone H3 at 'Lys-36' (H3K36me3) (PubMed:22099308). However, specifically trimethylates histone H3 at 'Lys-36' (H3K36me3) at euchromatic regions in embryonic stem (ES) cells (By similarity). By methylating histone H3 at 'Lys-36', involved in the regulation of gene transcription during various biological processes (PubMed:16115125, PubMed:22099308, PubMed:29728617). In ES cells, associates with developmental transcription factors such as SALL1 and represses inappropriate gene transcription mediated by histone deacetylation (By similarity). During heart development, associates with transcription factor NKX2-5 to repress transcription of NKX2-5 target genes (By similarity). Plays an essential role in adipogenesis, by regulating expression of genes involved in pre-adipocyte differentiation (PubMed:29728617). During T-cell receptor (TCR) and CD28-mediated T-cell activation, promotes the transcription of transcription factor BCL6 which is required for follicular helper T (Tfh) cell differentiation (By similarity). During B-cell development, required for the generation of the B1 lineage (By similarity). During B2 cell activation, may contribute to the control of isotype class switch recombination (CRS), splenic germinal center formation, and the humoral immune response (By similarity). Plays a role in class switch recombination of the immunoglobulin heavy chain (IgH) locus during B-cell activation (By similarity). By regulating the methylation of histone H3 at 'Lys-36' and histone H4 at 'Lys-20' at the IgH locus, involved in TP53BP1 recruitment to the IgH switch region and promotes the transcription of IgA (By similarity). {ECO:0000250|UniProtKB:Q8BVE8, ECO:0000269|PubMed:16115125, ECO:0000269|PubMed:19808676, ECO:0000269|PubMed:22099308, ECO:0000269|PubMed:27571355, ECO:0000269|PubMed:29728617, ECO:0000269|PubMed:33941880}.; FUNCTION: [Isoform 1]: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2). {ECO:0000269|PubMed:22099308}.; FUNCTION: [Isoform 4]: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:22099308). Methylation of histone H3 at 'Lys-27' is controversial (PubMed:18172012, PubMed:22099308). Mono-, di- or tri-methylates histone H3 at 'Lys-27' (H3K27me, H3K27me2 and H3K27me3) (PubMed:18172012). Does not methylate histone H3 at 'Lys-27' (PubMed:22099308). May act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment (PubMed:11152655, PubMed:18172012). {ECO:0000269|PubMed:11152655, ECO:0000269|PubMed:18172012, ECO:0000269|PubMed:22099308}. |
| P00918 | CA2 | S165 | ochoa | Carbonic anhydrase 2 (EC 4.2.1.1) (Carbonate dehydratase II) (Carbonic anhydrase C) (CAC) (Carbonic anhydrase II) (CA-II) (Cyanamide hydratase CA2) (EC 4.2.1.69) | Catalyzes the reversible hydration of carbon dioxide (PubMed:11327835, PubMed:11802772, PubMed:11831900, PubMed:12056894, PubMed:12171926, PubMed:1336460, PubMed:14736236, PubMed:15300855, PubMed:15453828, PubMed:15667203, PubMed:15865431, PubMed:16106378, PubMed:16214338, PubMed:16290146, PubMed:16686544, PubMed:16759856, PubMed:16807956, PubMed:17127057, PubMed:17251017, PubMed:17314045, PubMed:17330962, PubMed:17346964, PubMed:17540563, PubMed:17588751, PubMed:17705204, PubMed:18024029, PubMed:18162396, PubMed:18266323, PubMed:18374572, PubMed:18481843, PubMed:18618712, PubMed:18640037, PubMed:18942852, PubMed:1909891, PubMed:1910042, PubMed:19170619, PubMed:19186056, PubMed:19206230, PubMed:19520834, PubMed:19778001, PubMed:7761440, PubMed:7901850, PubMed:8218160, PubMed:8262987, PubMed:8399159, PubMed:8451242, PubMed:8485129, PubMed:8639494, PubMed:9265618, PubMed:9398308). Can also hydrate cyanamide to urea (PubMed:10550681, PubMed:11015219). Stimulates the chloride-bicarbonate exchange activity of SLC26A6 (PubMed:15990874). Essential for bone resorption and osteoclast differentiation (PubMed:15300855). Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. {ECO:0000269|PubMed:10550681, ECO:0000269|PubMed:11015219, ECO:0000269|PubMed:11327835, ECO:0000269|PubMed:11802772, ECO:0000269|PubMed:11831900, ECO:0000269|PubMed:12056894, ECO:0000269|PubMed:12171926, ECO:0000269|PubMed:1336460, ECO:0000269|PubMed:14736236, ECO:0000269|PubMed:15300855, ECO:0000269|PubMed:15453828, ECO:0000269|PubMed:15667203, ECO:0000269|PubMed:15865431, ECO:0000269|PubMed:15990874, ECO:0000269|PubMed:16106378, ECO:0000269|PubMed:16214338, ECO:0000269|PubMed:16290146, ECO:0000269|PubMed:16686544, ECO:0000269|PubMed:16759856, ECO:0000269|PubMed:16807956, ECO:0000269|PubMed:17127057, ECO:0000269|PubMed:17251017, ECO:0000269|PubMed:17314045, ECO:0000269|PubMed:17330962, ECO:0000269|PubMed:17346964, ECO:0000269|PubMed:17540563, ECO:0000269|PubMed:17588751, ECO:0000269|PubMed:17705204, ECO:0000269|PubMed:18024029, ECO:0000269|PubMed:18162396, ECO:0000269|PubMed:18266323, ECO:0000269|PubMed:18374572, ECO:0000269|PubMed:18481843, ECO:0000269|PubMed:18618712, ECO:0000269|PubMed:18640037, ECO:0000269|PubMed:18942852, ECO:0000269|PubMed:1909891, ECO:0000269|PubMed:1910042, ECO:0000269|PubMed:19170619, ECO:0000269|PubMed:19186056, ECO:0000269|PubMed:19206230, ECO:0000269|PubMed:19520834, ECO:0000269|PubMed:19778001, ECO:0000269|PubMed:7761440, ECO:0000269|PubMed:7901850, ECO:0000269|PubMed:8218160, ECO:0000269|PubMed:8262987, ECO:0000269|PubMed:8399159, ECO:0000269|PubMed:8451242, ECO:0000269|PubMed:8485129, ECO:0000269|PubMed:8639494, ECO:0000269|PubMed:9265618, ECO:0000269|PubMed:9398308}. |
| P02795 | MT2A | S35 | ochoa | Metallothionein-2 (MT-2) (Metallothionein-2A) (Metallothionein-II) (MT-II) | Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. |
| P03372 | ESR1 | S236 | psp | Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1) | Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (PubMed:17922032). Maintains neuronal survival in response to ischemic reperfusion injury when in the presence of circulating estradiol (17-beta-estradiol/E2) (By similarity). {ECO:0000250|UniProtKB:P06211, ECO:0000269|PubMed:10681512, ECO:0000269|PubMed:10816575, ECO:0000269|PubMed:11477071, ECO:0000269|PubMed:11682626, ECO:0000269|PubMed:14764652, ECO:0000269|PubMed:15078875, ECO:0000269|PubMed:15891768, ECO:0000269|PubMed:16043358, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:17922032, ECO:0000269|PubMed:17932106, ECO:0000269|PubMed:18247370, ECO:0000269|PubMed:19350539, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20705611, ECO:0000269|PubMed:21330404, ECO:0000269|PubMed:22083956, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:7651415, ECO:0000269|PubMed:9328340}.; FUNCTION: [Isoform 3]: Involved in activation of NOS3 and endothelial nitric oxide production (PubMed:21937726). Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full-length receptor (PubMed:10970861). Binds to ERE and inhibits isoform 1 (PubMed:10970861). {ECO:0000269|PubMed:10970861, ECO:0000269|PubMed:21937726}. |
| P04150 | NR3C1 | S305 | ochoa | Glucocorticoid receptor (GR) (Nuclear receptor subfamily 3 group C member 1) | Receptor for glucocorticoids (GC) (PubMed:27120390, PubMed:37478846). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors (PubMed:28139699). Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:25775514, ECO:0000269|PubMed:27120390, ECO:0000269|PubMed:28139699, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:9590696}.; FUNCTION: [Isoform Alpha]: Has transcriptional activation and repression activity (PubMed:11435610, PubMed:15769988, PubMed:15866175, PubMed:17635946, PubMed:19141540, PubMed:19248771, PubMed:20484466, PubMed:21664385, PubMed:23820903). Mediates glucocorticoid-induced apoptosis (PubMed:23303127). Promotes accurate chromosome segregation during mitosis (PubMed:25847991). May act as a tumor suppressor (PubMed:25847991). May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression (By similarity). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:11435610, ECO:0000269|PubMed:15769988, ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:17635946, ECO:0000269|PubMed:19141540, ECO:0000269|PubMed:19248771, ECO:0000269|PubMed:20484466, ECO:0000269|PubMed:21664385, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903, ECO:0000269|PubMed:25847991}.; FUNCTION: [Isoform Beta]: Acts as a dominant negative inhibitor of isoform Alpha (PubMed:20484466, PubMed:7769088, PubMed:8621628). Has intrinsic transcriptional activity independent of isoform Alpha when both isoforms are coexpressed (PubMed:19248771, PubMed:26711253). Loses this transcription modulator function on its own (PubMed:20484466). Has no hormone-binding activity (PubMed:8621628). May play a role in controlling glucose metabolism by maintaining insulin sensitivity (By similarity). Reduces hepatic gluconeogenesis through down-regulation of PEPCK in an isoform Alpha-dependent manner (PubMed:26711253). Directly regulates STAT1 expression in isoform Alpha-independent manner (PubMed:26711253). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:19248771, ECO:0000269|PubMed:20484466, ECO:0000269|PubMed:26711253, ECO:0000269|PubMed:7769088, ECO:0000269|PubMed:8621628}.; FUNCTION: [Isoform Alpha-2]: Has lower transcriptional activation activity than isoform Alpha. Exerts a dominant negative effect on isoform Alpha trans-repression mechanism (PubMed:20484466).; FUNCTION: [Isoform GR-P]: Increases activity of isoform Alpha. {ECO:0000269|PubMed:11358809}.; FUNCTION: [Isoform Alpha-B]: More effective than isoform Alpha in transcriptional activation, but not repression activity. {ECO:0000269|PubMed:11435610, ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform 10]: Has transcriptional activation activity. {ECO:0000269|PubMed:20484466}.; FUNCTION: [Isoform Alpha-C1]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-C2]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-C3]: Has highest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127). Mediates glucocorticoid-induced apoptosis (PubMed:23303127, PubMed:23820903). {ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903}.; FUNCTION: [Isoform Alpha-D1]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-D2]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-D3]: Has lowest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127). {ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903}. |
| P04406 | GAPDH | S151 | ochoa | Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (Peptidyl-cysteine S-nitrosylase GAPDH) (EC 2.6.99.-) | Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively (PubMed:11724794, PubMed:3170585). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (PubMed:11724794, PubMed:3170585). Modulates the organization and assembly of the cytoskeleton (By similarity). Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes (PubMed:23071094). Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (PubMed:23071094). Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (PubMed:23332158, PubMed:27387501). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis (By similarity). Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity). {ECO:0000250|UniProtKB:P04797, ECO:0000269|PubMed:11724794, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23332158, ECO:0000269|PubMed:27387501, ECO:0000269|PubMed:3170585}. |
| P04732 | MT1E | S35 | ochoa | Metallothionein-1E (MT-1E) (Metallothionein-IE) (MT-IE) | Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. |
| P07451 | CA3 | S48 | ochoa | Carbonic anhydrase 3 (EC 4.2.1.1) (Carbonate dehydratase III) (Carbonic anhydrase III) (CA-III) | Reversible hydration of carbon dioxide. {ECO:0000269|PubMed:17427958, ECO:0000269|PubMed:18618712}. |
| P08631 | HCK | S214 | ochoa | Tyrosine-protein kinase HCK (EC 2.7.10.2) (Hematopoietic cell kinase) (Hemopoietic cell kinase) (p59-HCK/p60-HCK) (p59Hck) (p61Hck) | Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS. {ECO:0000269|PubMed:10092522, ECO:0000269|PubMed:10779760, ECO:0000269|PubMed:10973280, ECO:0000269|PubMed:11741929, ECO:0000269|PubMed:11896602, ECO:0000269|PubMed:12411494, ECO:0000269|PubMed:15010462, ECO:0000269|PubMed:15952790, ECO:0000269|PubMed:15998323, ECO:0000269|PubMed:17310994, ECO:0000269|PubMed:17535448, ECO:0000269|PubMed:19114024, ECO:0000269|PubMed:19903482, ECO:0000269|PubMed:20452982, ECO:0000269|PubMed:21338576, ECO:0000269|PubMed:7535819, ECO:0000269|PubMed:8132624, ECO:0000269|PubMed:9406996, ECO:0000269|PubMed:9407116}. |
| P0DJD0 | RGPD1 | S1527 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | S1535 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P13640 | MT1G | S36 | ochoa | Metallothionein-1G (MT-1G) (Metallothionein-1K) (MT-1K) (Metallothionein-IG) (MT-IG) | Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. |
| P14923 | JUP | S24 | ochoa | Junction plakoglobin (Catenin gamma) (Desmoplakin III) (Desmoplakin-3) | Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity). {ECO:0000250}. |
| P15924 | DSP | S2209 | ochoa | Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) | Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). {ECO:0000250|UniProtKB:F1LMV6}. |
| P17948 | FLT1 | S1207 | ochoa | Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase FRT) (Tyrosine-protein kinase receptor FLT) (FLT) (Vascular permeability factor receptor) | Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. Acts as a positive regulator of postnatal retinal hyaloid vessel regression (By similarity). May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC and YES1, and may also phosphorylate CBL. Promotes phosphorylation of AKT1 at 'Ser-473'. Promotes phosphorylation of PTK2/FAK1 (PubMed:16685275). {ECO:0000250|UniProtKB:P35969, ECO:0000269|PubMed:11141500, ECO:0000269|PubMed:11312102, ECO:0000269|PubMed:11811792, ECO:0000269|PubMed:12796773, ECO:0000269|PubMed:14633857, ECO:0000269|PubMed:15735759, ECO:0000269|PubMed:16685275, ECO:0000269|PubMed:18079407, ECO:0000269|PubMed:18515749, ECO:0000269|PubMed:18583712, ECO:0000269|PubMed:18593464, ECO:0000269|PubMed:20512933, ECO:0000269|PubMed:20551949, ECO:0000269|PubMed:21752276, ECO:0000269|PubMed:7824266, ECO:0000269|PubMed:8248162, ECO:0000269|PubMed:8605350, ECO:0000269|PubMed:9299537, ECO:0000269|Ref.11}.; FUNCTION: [Isoform 1]: Phosphorylates PLCG. {ECO:0000269|PubMed:9299537}.; FUNCTION: [Isoform 2]: May function as decoy receptor for VEGFA. {ECO:0000269|PubMed:21752276}.; FUNCTION: [Isoform 3]: May function as decoy receptor for VEGFA. {ECO:0000269|PubMed:21752276}.; FUNCTION: [Isoform 4]: May function as decoy receptor for VEGFA. {ECO:0000269|PubMed:21752276}.; FUNCTION: [Isoform 7]: Has a truncated kinase domain; it increases phosphorylation of SRC at 'Tyr-418' by unknown means and promotes tumor cell invasion. {ECO:0000269|PubMed:20512933}. |
| P18859 | ATP5PF | S65 | ochoa | ATP synthase peripheral stalk subunit F6, mitochondrial (ATPase subunit F6) (ATP synthase peripheral stalk subunit F6) | Subunit F6, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (PubMed:37244256). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (PubMed:37244256). Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (By similarity). {ECO:0000250|UniProtKB:P02721, ECO:0000250|UniProtKB:P19483, ECO:0000269|PubMed:37244256, ECO:0000305|PubMed:37244256}. |
| P21333 | FLNA | S1411 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P21953 | BCKDHB | S318 | psp | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial (EC 1.2.4.4) (Branched-chain alpha-keto acid dehydrogenase E1 component beta chain) (BCKDE1B) (BCKDH E1-beta) | Together with BCKDHA forms the heterotetrameric E1 subunit of the mitochondrial branched-chain alpha-ketoacid dehydrogenase (BCKD) complex. The BCKD complex catalyzes the multi-step oxidative decarboxylation of alpha-ketoacids derived from the branched-chain amino-acids valine, leucine and isoleucine producing CO2 and acyl-CoA which is subsequently utilized to produce energy. The E1 subunit catalyzes the first step with the decarboxylation of the alpha-ketoacid forming an enzyme-product intermediate. A reductive acylation mediated by the lipoylamide cofactor of E2 extracts the acyl group from the E1 active site for the next step of the reaction. {ECO:0000269|PubMed:10745006, ECO:0000269|PubMed:9582350}. |
| P22626 | HNRNPA2B1 | S58 | ochoa | Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1) | Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs (PubMed:19099192). Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (PubMed:10567417). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts (PubMed:26321680). Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs (PubMed:24356509). Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (PubMed:26321680). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Also plays a role in the activation of the innate immune response (PubMed:31320558). Mechanistically, senses the presence of viral DNA in the nucleus, homodimerizes and is demethylated by JMJD6 (PubMed:31320558). In turn, translocates to the cytoplasm where it activates the TBK1-IRF3 pathway, leading to interferon alpha/beta production (PubMed:31320558). {ECO:0000250|UniProtKB:A7VJC2, ECO:0000269|PubMed:10567417, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:24356509, ECO:0000269|PubMed:26321680, ECO:0000303|PubMed:19099192}.; FUNCTION: (Microbial infection) Involved in the transport of HIV-1 genomic RNA out of the nucleus, to the microtubule organizing center (MTOC), and then from the MTOC to the cytoplasm: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) sequence motifs present on HIV-1 genomic RNA, and promotes its transport. {ECO:0000269|PubMed:15294897, ECO:0000269|PubMed:17004321}. |
| P23526 | AHCY | S154 | ochoa | Adenosylhomocysteinase (AdoHcyase) (EC 3.13.2.1) (S-adenosyl-L-homocysteine hydrolase) | Catalyzes the hydrolysis of S-adenosyl-L-homocysteine to form adenosine and homocysteine (PubMed:10933798). Binds copper ions (By similarity). {ECO:0000250|UniProtKB:P50247, ECO:0000269|PubMed:10933798}. |
| P24043 | LAMA2 | S2502 | ochoa | Laminin subunit alpha-2 (Laminin M chain) (Laminin-12 subunit alpha) (Laminin-2 subunit alpha) (Laminin-4 subunit alpha) (Merosin heavy chain) | Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. |
| P27816 | MAP4 | S1002 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P30086 | PEBP1 | S52 | ochoa|psp | Phosphatidylethanolamine-binding protein 1 (PEBP-1) (HCNPpp) (Neuropolypeptide h3) (Prostatic-binding protein) (Raf kinase inhibitor protein) (RKIP) [Cleaved into: Hippocampal cholinergic neurostimulating peptide (HCNP)] | Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation. {ECO:0000250, ECO:0000269|PubMed:18294816}.; FUNCTION: HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity). {ECO:0000250}. |
| P31949 | S100A11 | S41 | ochoa | Protein S100-A11 (Calgizzarin) (Metastatic lymph node gene 70 protein) (MLN 70) (Protein S100-C) (S100 calcium-binding protein A11) [Cleaved into: Protein S100-A11, N-terminally processed] | Facilitates the differentiation and the cornification of keratinocytes. {ECO:0000269|PubMed:18618420}. |
| P32119 | PRDX2 | S76 | psp | Peroxiredoxin-2 (EC 1.11.1.24) (Natural killer cell-enhancing factor B) (NKEF-B) (PRP) (Thiol-specific antioxidant protein) (TSA) (Thioredoxin peroxidase 1) (Thioredoxin-dependent peroxide reductase 1) (Thioredoxin-dependent peroxiredoxin 2) | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). {ECO:0000269|PubMed:9497357}. |
| P35442 | THBS2 | S238 | ochoa | Thrombospondin-2 | Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties. {ECO:0000269|PubMed:20714802}. |
| P35637 | FUS | S439 | psp | RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein) | DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response (PubMed:27731383). Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing (PubMed:26124092). Also binds its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay (PubMed:24204307). Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (PubMed:10567410). In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity). {ECO:0000250|UniProtKB:P56959, ECO:0000269|PubMed:10567410, ECO:0000269|PubMed:21256132, ECO:0000269|PubMed:24204307, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27731383}. |
| P36873 | PPP1CC | S182 | ochoa | Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC 3.1.3.16) (Protein phosphatase 1C catalytic subunit) | Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets (PubMed:17936702, PubMed:25012651). Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1 (PubMed:17936702). Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (PubMed:20516061). In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation (PubMed:21712997). May dephosphorylate CSNK1D and CSNK1E (By similarity). Regulates the recruitment of the SKA complex to kinetochores (PubMed:28982702). Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Together with PPP1CA (PP1-alpha subunit), dephosphorylates IFIH1/MDA5 and RIG-I leading to their activation and a functional innate immune response (PubMed:23499489). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (PubMed:35768504, PubMed:35831509). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (PubMed:35768504, PubMed:35831509). Dephosphorylates MKI67 at the onset of anaphase (PubMed:25012651). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (PubMed:35768504, PubMed:35831509). {ECO:0000250|UniProtKB:P63087, ECO:0000269|PubMed:17936702, ECO:0000269|PubMed:20516061, ECO:0000269|PubMed:21712997, ECO:0000269|PubMed:23396208, ECO:0000269|PubMed:23499489, ECO:0000269|PubMed:25012651, ECO:0000269|PubMed:28982702, ECO:0000269|PubMed:35768504, ECO:0000269|PubMed:35831509}. |
| P49792 | RANBP2 | S2518 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P52292 | KPNA2 | S54 | ochoa | Importin subunit alpha-1 (Karyopherin subunit alpha-2) (RAG cohort protein 1) (SRP1-alpha) | Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1 (PubMed:28991411, PubMed:32130408, PubMed:7604027, PubMed:7754385). Binds specifically and directly to substrates containing either a simple or bipartite NLS motif (PubMed:28991411, PubMed:32130408, PubMed:7604027, PubMed:7754385). Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:7604027, PubMed:7754385). At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediator of PR-DUB complex component BAP1 nuclear import; acts redundantly with KPNA1 and Transportin-1/TNPO1 (PubMed:35446349). {ECO:0000269|PubMed:28991411, ECO:0000269|PubMed:32130408, ECO:0000269|PubMed:35446349, ECO:0000269|PubMed:7604027, ECO:0000269|PubMed:7754385}. |
| P53350 | PLK1 | S375 | ochoa | Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13) | Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis (PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:23455478, PubMed:23509069, PubMed:28512243, PubMed:8991084). Polo-like kinase proteins act by binding and phosphorylating proteins that are already phosphorylated on a specific motif recognized by the POLO box domains (PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:23455478, PubMed:23509069, PubMed:28512243, PubMed:8991084). Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, MRE11, PPP1R12A/MYPT1, POLQ, PRC1, RACGAP1/CYK4, RAD51, RHNO1, SGO1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1, WEE1 and HNRNPU (PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17218258, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:22325354, PubMed:23455478, PubMed:23509069, PubMed:25986610, PubMed:26811421, PubMed:28512243, PubMed:37440612, PubMed:37674080, PubMed:8991084). Plays a key role in centrosome functions and the assembly of bipolar spindles by phosphorylating KIZ, NEDD1 and NINL (PubMed:16980960, PubMed:19509060). NEDD1 phosphorylation promotes subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation (PubMed:19509060). Phosphorylation of NINL component of the centrosome leads to NINL dissociation from other centrosomal proteins (PubMed:12852856). Involved in mitosis exit and cytokinesis by phosphorylating CEP55, ECT2, KIF20A/MKLP2, CENPU, PRC1 and RACGAP1 (PubMed:12939256, PubMed:16247472, PubMed:17351640, PubMed:19468300, PubMed:19468302). Recruited at the central spindle by phosphorylating and docking PRC1 and KIF20A/MKLP2; creates its own docking sites on PRC1 and KIF20A/MKLP2 by mediating phosphorylation of sites subsequently recognized by the POLO box domains (PubMed:12939256, PubMed:17351640). Phosphorylates RACGAP1, thereby creating a docking site for the Rho GTP exchange factor ECT2 that is essential for the cleavage furrow formation (PubMed:19468300, PubMed:19468302). Promotes the central spindle recruitment of ECT2 (PubMed:16247472). Plays a central role in G2/M transition of mitotic cell cycle by phosphorylating CCNB1, CDC25C, FOXM1, CENPU, PKMYT1/MYT1, PPP1R12A/MYPT1 and WEE1 (PubMed:11202906, PubMed:12447691, PubMed:12524548, PubMed:19160488). Part of a regulatory circuit that promotes the activation of CDK1 by phosphorylating the positive regulator CDC25C and inhibiting the negative regulators WEE1 and PKMYT1/MYT1 (PubMed:11202906). Also acts by mediating phosphorylation of cyclin-B1 (CCNB1) on centrosomes in prophase (PubMed:12447691, PubMed:12524548). Phosphorylates FOXM1, a key mitotic transcription regulator, leading to enhance FOXM1 transcriptional activity (PubMed:19160488). Involved in kinetochore functions and sister chromatid cohesion by phosphorylating BUB1B/BUBR1, FBXO5/EMI1 and STAG2/SA2 (PubMed:15148369, PubMed:15469984, PubMed:17376779, PubMed:18331714). PLK1 is high on non-attached kinetochores suggesting a role of PLK1 in kinetochore attachment or in spindle assembly checkpoint (SAC) regulation (PubMed:17617734). Required for kinetochore localization of BUB1B (PubMed:17376779). Regulates the dissociation of cohesin from chromosomes by phosphorylating cohesin subunits such as STAG2/SA2 (By similarity). Phosphorylates SGO1: required for spindle pole localization of isoform 3 of SGO1 and plays a role in regulating its centriole cohesion function (PubMed:18331714). Mediates phosphorylation of FBXO5/EMI1, a negative regulator of the APC/C complex during prophase, leading to FBXO5/EMI1 ubiquitination and degradation by the proteasome (PubMed:15148369, PubMed:15469984). Acts as a negative regulator of p53 family members: phosphorylates TOPORS, leading to inhibit the sumoylation of p53/TP53 and simultaneously enhance the ubiquitination and subsequent degradation of p53/TP53 (PubMed:19473992). Phosphorylates the transactivation domain of the transcription factor p73/TP73, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates BORA, and thereby promotes the degradation of BORA (PubMed:18521620). Contributes to the regulation of AURKA function (PubMed:18615013, PubMed:18662541). Also required for recovery after DNA damage checkpoint and entry into mitosis (PubMed:18615013, PubMed:18662541). Phosphorylates MISP, leading to stabilization of cortical and astral microtubule attachments required for proper spindle positioning (PubMed:23509069). Together with MEIKIN, acts as a regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage (By similarity). Phosphorylates CEP68 and is required for its degradation (PubMed:25503564). Regulates nuclear envelope breakdown during prophase by phosphorylating DCTN1 resulting in its localization in the nuclear envelope (PubMed:20679239). Phosphorylates the heat shock transcription factor HSF1, promoting HSF1 nuclear translocation upon heat shock (PubMed:15661742). Phosphorylates HSF1 also in the early mitotic period; this phosphorylation regulates HSF1 localization to the spindle pole, the recruitment of the SCF(BTRC) ubiquitin ligase complex induicing HSF1 degradation, and hence mitotic progression (PubMed:18794143). Regulates mitotic progression by phosphorylating RIOK2 (PubMed:21880710). Through the phosphorylation of DZIP1 regulates the localization during mitosis of the BBSome, a ciliary protein complex involved in cilium biogenesis (PubMed:27979967). Regulates DNA repair during mitosis by mediating phosphorylation of POLQ and RHNO1, thereby promoting POLQ recruitment to DNA damage sites (PubMed:37440612, PubMed:37674080). Phosphorylates ATXN10 which may play a role in the regulation of cytokinesis and may stimulate the proteasome-mediated degradation of ATXN10 (PubMed:21857149). {ECO:0000250|UniProtKB:P70032, ECO:0000250|UniProtKB:Q5F2C3, ECO:0000269|PubMed:11202906, ECO:0000269|PubMed:12207013, ECO:0000269|PubMed:12447691, ECO:0000269|PubMed:12524548, ECO:0000269|PubMed:12738781, ECO:0000269|PubMed:12852856, ECO:0000269|PubMed:12939256, ECO:0000269|PubMed:14532005, ECO:0000269|PubMed:14734534, ECO:0000269|PubMed:15070733, ECO:0000269|PubMed:15148369, ECO:0000269|PubMed:15469984, ECO:0000269|PubMed:15661742, ECO:0000269|PubMed:16198290, ECO:0000269|PubMed:16247472, ECO:0000269|PubMed:16980960, ECO:0000269|PubMed:17081991, ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:17351640, ECO:0000269|PubMed:17376779, ECO:0000269|PubMed:17617734, ECO:0000269|PubMed:18174154, ECO:0000269|PubMed:18331714, ECO:0000269|PubMed:18418051, ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:18521620, ECO:0000269|PubMed:18615013, ECO:0000269|PubMed:18662541, ECO:0000269|PubMed:18794143, ECO:0000269|PubMed:19160488, ECO:0000269|PubMed:19351716, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19468302, ECO:0000269|PubMed:19473992, ECO:0000269|PubMed:19509060, ECO:0000269|PubMed:19597481, ECO:0000269|PubMed:20679239, ECO:0000269|PubMed:21857149, ECO:0000269|PubMed:21880710, ECO:0000269|PubMed:22325354, ECO:0000269|PubMed:23455478, ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:25986610, ECO:0000269|PubMed:26811421, ECO:0000269|PubMed:27979967, ECO:0000269|PubMed:37440612, ECO:0000269|PubMed:37674080, ECO:0000269|PubMed:8991084}. |
| P55265 | ADAR | S1089 | ochoa | Double-stranded RNA-specific adenosine deaminase (DRADA) (EC 3.5.4.37) (136 kDa double-stranded RNA-binding protein) (p136) (Interferon-inducible protein 4) (IFI-4) (K88DSRBP) | Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing (PubMed:12618436, PubMed:7565688, PubMed:7972084). This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins since the translational machinery read the inosine as a guanosine; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2) and serotonin (HTR2C) and GABA receptor (GABRA3). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alters their functional activities. Exhibits low-level editing at the GRIA2 Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Its viral RNA substrates include: hepatitis C virus (HCV), vesicular stomatitis virus (VSV), measles virus (MV), hepatitis delta virus (HDV), and human immunodeficiency virus type 1 (HIV-1). Exhibits either a proviral (HDV, MV, VSV and HIV-1) or an antiviral effect (HCV) and this can be editing-dependent (HDV and HCV), editing-independent (VSV and MV) or both (HIV-1). Impairs HCV replication via RNA editing at multiple sites. Enhances the replication of MV, VSV and HIV-1 through an editing-independent mechanism via suppression of EIF2AK2/PKR activation and function. Stimulates both the release and infectivity of HIV-1 viral particles by an editing-dependent mechanism where it associates with viral RNAs and edits adenosines in the 5'UTR and the Rev and Tat coding sequence. Can enhance viral replication of HDV via A-to-I editing at a site designated as amber/W, thereby changing an UAG amber stop codon to an UIG tryptophan (W) codon that permits synthesis of the large delta antigen (L-HDAg) which has a key role in the assembly of viral particles. However, high levels of ADAR1 inhibit HDV replication. {ECO:0000269|PubMed:12618436, ECO:0000269|PubMed:15556947, ECO:0000269|PubMed:15858013, ECO:0000269|PubMed:16120648, ECO:0000269|PubMed:16475990, ECO:0000269|PubMed:17079286, ECO:0000269|PubMed:19605474, ECO:0000269|PubMed:19651874, ECO:0000269|PubMed:19710021, ECO:0000269|PubMed:19908260, ECO:0000269|PubMed:21289159, ECO:0000269|PubMed:22278222, ECO:0000269|PubMed:7565688, ECO:0000269|PubMed:7972084}. |
| P60709 | ACTB | S338 | ochoa | Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] | Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (PubMed:39321809, PubMed:38609661). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:Q6QAQ1, ECO:0000269|PubMed:25255767, ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| P62136 | PPP1CA | S182 | ochoa | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16) | Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets (PubMed:28216226, PubMed:30158517, PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670, PubMed:39603239, PubMed:39603240). Protein phosphatase 1 (PP1) is essential for cell division, transcription elongation, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670, PubMed:39603239, PubMed:39603240). Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Catalytic component of the PNUTS-PP1 protein phosphatase complex, a protein phosphatase 1 (PP1) complex that promotes RNA polymerase II transcription pause-release, allowing transcription elongation: the PNUTS-PP1 complex mediates the release of RNA polymerase II from promoter-proximal region of genes by catalyzing dephosphorylation of proteins involved in transcription, such as AFF4, CDK9, MEPCE, INTS12, NCBP1, POLR2M/GDOWN1 and SUPT6H (PubMed:39603239, PubMed:39603240). The PNUTS-PP1 complex also regulates transcription termination by mediating dephosphorylation of SUPT5H in termination zones downstream of poly(A) sites, thereby promoting deceleration of RNA polymerase II transcription (PubMed:31677974). PNUTS-PP1 complex is also involved in the response to replication stress by mediating dephosphorylation of POLR2A at 'Ser-5' of the CTD, promoting RNA polymerase II degradation (PubMed:33264625). PNUTS-PP1 also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (PubMed:20516061). Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage (PubMed:17283141). Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development (By similarity). In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation (PubMed:21712997). May dephosphorylate CSNK1D and CSNK1E (PubMed:21712997). Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Dephosphorylates CENPA (PubMed:25556658). Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy (PubMed:26083323). Together with PPP1CC (PP1-gamma subunit), dephosphorylates IFIH1/MDA5 and RIG-I leading to their activation and a functional innate immune response (PubMed:23499489). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (PubMed:35768504, PubMed:36175670). {ECO:0000250|UniProtKB:P62137, ECO:0000269|PubMed:17283141, ECO:0000269|PubMed:20516061, ECO:0000269|PubMed:21712997, ECO:0000269|PubMed:23396208, ECO:0000269|PubMed:23499489, ECO:0000269|PubMed:25556658, ECO:0000269|PubMed:26083323, ECO:0000269|PubMed:28216226, ECO:0000269|PubMed:30158517, ECO:0000269|PubMed:31677974, ECO:0000269|PubMed:33264625, ECO:0000269|PubMed:35768504, ECO:0000269|PubMed:35830882, ECO:0000269|PubMed:35831509, ECO:0000269|PubMed:36175670, ECO:0000269|PubMed:39603239, ECO:0000269|PubMed:39603240}.; FUNCTION: (Microbial infection) Necessary for alphaviruses replication. {ECO:0000269|PubMed:29769351}. |
| P62140 | PPP1CB | S181 | ochoa | Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (PPP1CD) (EC 3.1.3.16) (EC 3.1.3.53) | Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (PubMed:35768504, PubMed:35831509, PubMed:36175670). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (PubMed:35768504, PubMed:35831509, PubMed:36175670). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (PubMed:35768504, PubMed:36175670). {ECO:0000269|PubMed:20516061, ECO:0000269|PubMed:21712997, ECO:0000269|PubMed:23396208, ECO:0000269|PubMed:35768504, ECO:0000269|PubMed:35831509, ECO:0000269|PubMed:36175670}. |
| P62753 | RPS6 | S148 | ochoa | Small ribosomal subunit protein eS6 (40S ribosomal protein S6) (Phosphoprotein NP33) | Component of the 40S small ribosomal subunit (PubMed:23636399, PubMed:8706699). Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (PubMed:17220279). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:17220279, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:8706699}. |
| P63261 | ACTG1 | S338 | ochoa | Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage (By similarity). {ECO:0000250|UniProtKB:P63260, ECO:0000305|PubMed:29581253}. |
| P80297 | MT1X | S35 | ochoa | Metallothionein-1X (MT-1X) (Metallothionein-IX) (MT-IX) | Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. May be involved in FAM168A anti-apoptotic signaling (PubMed:23251525). {ECO:0000269|PubMed:23251525}. |
| P98161 | PKD1 | S916 | psp | Polycystin-1 (PC1) (Autosomal dominant polycystic kidney disease 1 protein) | Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B (PubMed:27214281). Both PKD1 and PKD2 are required for channel activity (PubMed:27214281). Involved in renal tubulogenesis (PubMed:12482949). Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (By similarity). Acts as a regulator of cilium length, together with PKD2 (By similarity). The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling (By similarity). The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling (By similarity). May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate interactions. Likely to be involved with polycystin-1-interacting protein 1 in the detection, sequestration and exocytosis of senescent mitochondria (PubMed:37681898). {ECO:0000250|UniProtKB:O08852, ECO:0000269|PubMed:12482949, ECO:0000269|PubMed:27214281, ECO:0000269|PubMed:37681898}. |
| Q00341 | HDLBP | S583 | ochoa | Vigilin (High density lipoprotein-binding protein) (HDL-binding protein) | Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol. |
| Q00610 | CLTC | S67 | ochoa | Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17) | Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872). Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilization of the lattice promoting uncoating (By similarity). {ECO:0000250|UniProtKB:P49951, ECO:0000269|PubMed:15858577, ECO:0000269|PubMed:16968737, ECO:0000269|PubMed:20639872, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}. |
| Q03431 | PTH1R | S473 | psp | Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH/PTHrP type I receptor) (PTH/PTHr receptor) (Parathyroid hormone 1 receptor) (PTH1 receptor) | G-protein-coupled receptor for parathyroid hormone (PTH) and for parathyroid hormone-related peptide (PTHLH) (PubMed:10913300, PubMed:18375760, PubMed:19674967, PubMed:27160269, PubMed:30975883, PubMed:35932760, PubMed:8397094). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (cAMP) (PubMed:30975883, PubMed:35932760). PTH1R is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (PubMed:20172855, PubMed:30975883, PubMed:35932760). PTHLH dissociates from PTH1R more rapidly than PTH; as consequence, the cAMP response induced by PTHLH decays faster than the response induced by PTH (PubMed:35932760). {ECO:0000269|PubMed:10913300, ECO:0000269|PubMed:18375760, ECO:0000269|PubMed:19674967, ECO:0000269|PubMed:20172855, ECO:0000269|PubMed:27160269, ECO:0000269|PubMed:30975883, ECO:0000269|PubMed:35932760, ECO:0000269|PubMed:8397094}. |
| Q06187 | BTK | S371 | ochoa | Tyrosine-protein kinase BTK (EC 2.7.10.2) (Agammaglobulinemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Bruton tyrosine kinase) | Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling (PubMed:19290921). Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation (PubMed:19290921). After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members (PubMed:11606584). PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK (PubMed:11606584). BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways (PubMed:16517732, PubMed:17932028). Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway (PubMed:16517732). The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense (PubMed:16517732). Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells (PubMed:16517732, PubMed:17932028). Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation (PubMed:16415872). BTK also plays a critical role in transcription regulation (PubMed:19290921). Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes (PubMed:19290921). BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B (PubMed:19290921). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (PubMed:34554188). Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR (PubMed:9012831). GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression (PubMed:9012831). ARID3A and NFAT are other transcriptional target of BTK (PubMed:16738337). BTK is required for the formation of functional ARID3A DNA-binding complexes (PubMed:16738337). There is however no evidence that BTK itself binds directly to DNA (PubMed:16738337). BTK has a dual role in the regulation of apoptosis (PubMed:9751072). Plays a role in STING1-mediated induction of type I interferon (IFN) response by phosphorylating DDX41 (PubMed:25704810). {ECO:0000269|PubMed:11606584, ECO:0000269|PubMed:16415872, ECO:0000269|PubMed:16517732, ECO:0000269|PubMed:16738337, ECO:0000269|PubMed:17932028, ECO:0000269|PubMed:25704810, ECO:0000269|PubMed:34554188, ECO:0000269|PubMed:9012831, ECO:0000303|PubMed:19290921, ECO:0000303|PubMed:9751072}. |
| Q07912 | TNK2 | S529 | ochoa | Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Tyrosine kinase non-receptor protein 2) | Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR. Phosphorylates WASP (PubMed:20110370). {ECO:0000269|PubMed:10652228, ECO:0000269|PubMed:11278436, ECO:0000269|PubMed:16247015, ECO:0000269|PubMed:16257963, ECO:0000269|PubMed:16472662, ECO:0000269|PubMed:17038317, ECO:0000269|PubMed:18262180, ECO:0000269|PubMed:18435854, ECO:0000269|PubMed:19815557, ECO:0000269|PubMed:20110370, ECO:0000269|PubMed:20333297, ECO:0000269|PubMed:20383201}. |
| Q08AD1 | CAMSAP2 | S522 | ochoa | Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919, ECO:0000269|PubMed:24908486, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28726242}. |
| Q09666 | AHNAK | S691 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S3409 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S4715 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S5031 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S5414 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q09666 | AHNAK | S5577 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12789 | GTF3C1 | S501 | ochoa | General transcription factor 3C polypeptide 1 (TF3C-alpha) (TFIIIC box B-binding subunit) (Transcription factor IIIC 220 kDa subunit) (TFIIIC 220 kDa subunit) (TFIIIC220) (Transcription factor IIIC subunit alpha) | Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element. |
| Q12955 | ANK3 | S1405 | ochoa | Ankyrin-3 (ANK-3) (Ankyrin-G) | Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (PubMed:7836469). In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). {ECO:0000250|UniProtKB:G5E8K5, ECO:0000250|UniProtKB:O70511, ECO:0000269|PubMed:23903368, ECO:0000269|PubMed:7836469}.; FUNCTION: [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. {ECO:0000305|PubMed:17974005}. |
| Q13835 | PKP1 | S153 | ochoa | Plakophilin-1 (Band 6 protein) (B6P) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:23444369). Plays a role in desmosome protein expression regulation and localization to the desmosomal plaque, thereby maintaining cell sheet integrity and anchorage of desmosomes to intermediate filaments (PubMed:10852826, PubMed:23444369). Required for localization of DSG3 and YAP1 to the cell membrane in keratinocytes in response to mechanical strain, via the formation of an interaction complex composed of DSG3, YAP1, PKP1 and YWHAG (PubMed:31835537). Positively regulates differentiation of keratinocytes, potentially via promoting localization of DSG1 at desmosome cell junctions (By similarity). Required for calcium-independent development and maturation of desmosome plaques specifically at lateral cell-cell contacts in differentiating keratinocytes (By similarity). Plays a role in the maintenance of DSG3 protein abundance, DSG3 clustering and localization of these clusters to the cell membrane in keratinocytes (By similarity). May also promote keratinocyte proliferation and morphogenesis during postnatal development (PubMed:9326952). Required for tight junction inside-out transepidermal barrier function of the skin (By similarity). Promotes Wnt-mediated proliferation and differentiation of ameloblasts, via facilitating TJP1/ZO-1 localization to tight junctions (By similarity). Binds single-stranded DNA (ssDNA), and may thereby play a role in sensing DNA damage and promoting cell survival (PubMed:20613778). Positively regulates cap-dependent translation and as a result cell proliferation, via recruitment of EIF4A1 to the initiation complex and promotion of EIF4A1 ATPase activity (PubMed:20156963, PubMed:23444369). Regulates the mRNA stability and protein abundance of desmosome components PKP2, PKP3, DSC2 and DSP, potentially via its interaction with FXR1 (PubMed:25225333). {ECO:0000250|UniProtKB:P97350, ECO:0000269|PubMed:10852826, ECO:0000269|PubMed:20156963, ECO:0000269|PubMed:20613778, ECO:0000269|PubMed:23444369, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:31835537, ECO:0000269|PubMed:9326952}. |
| Q14315 | FLNC | S2646 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q14318 | FKBP8 | S296 | ochoa | Peptidyl-prolyl cis-trans isomerase FKBP8 (PPIase FKBP8) (EC 5.2.1.8) (38 kDa FK506-binding protein) (38 kDa FKBP) (FKBP-38) (hFKBP38) (FK506-binding protein 8) (FKBP-8) (FKBPR38) (Rotamase) | Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. Involved in the inhibition of viral infection by influenza A viruses (IAV) (PubMed:28169297). {ECO:0000269|PubMed:12510191, ECO:0000269|PubMed:15757646, ECO:0000269|PubMed:16176796, ECO:0000269|PubMed:28169297}. |
| Q14653 | IRF3 | S82 | psp | Interferon regulatory factor 3 (IRF-3) | Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses (PubMed:22394562, PubMed:24049179, PubMed:25636800, PubMed:27302953, PubMed:31340999, PubMed:36603579, PubMed:8524823). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:11846977, PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:32972995, PubMed:36603579, PubMed:8524823). Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction (PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:36603579). Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases (PubMed:22394562, PubMed:25636800, PubMed:27302953, PubMed:36603579). This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes (PubMed:16154084, PubMed:27302953, PubMed:33440148, PubMed:36603579). Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages (PubMed:16846591). In response to Sendai virus infection, is recruited by TOMM70:HSP90AA1 to mitochondrion and forms an apoptosis complex TOMM70:HSP90AA1:IRF3:BAX inducing apoptosis (PubMed:25609812). Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000269|PubMed:16154084, ECO:0000269|PubMed:22394562, ECO:0000269|PubMed:24049179, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27302953, ECO:0000269|PubMed:31340999, ECO:0000269|PubMed:31413131, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:33440148, ECO:0000269|PubMed:36603579, ECO:0000269|PubMed:8524823, ECO:0000303|PubMed:11846977, ECO:0000303|PubMed:16846591, ECO:0000303|PubMed:16979567, ECO:0000303|PubMed:20049431}. |
| Q14674 | ESPL1 | S1552 | psp | Separin (EC 3.4.22.49) (Caspase-like protein ESPL1) (Extra spindle poles-like 1 protein) (Separase) | Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms. {ECO:0000269|PubMed:10411507, ECO:0000269|PubMed:11509732}. |
| Q15020 | SART3 | S795 | ochoa | Spliceosome associated factor 3, U4/U6 recycling protein (Squamous cell carcinoma antigen recognized by T-cells 3) (SART-3) (Tat-interacting protein of 110 kDa) (Tip110) (p110 nuclear RNA-binding protein) | U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation (PubMed:12032085). Also binds U6atac snRNPs and may function as a recycling factor for U4atac/U6atac spliceosomal snRNP, an initial step in the assembly of U12-type spliceosomal complex. The U12-type spliceosomal complex plays a role in the splicing of introns with non-canonical splice sites (PubMed:14749385). May also function as a substrate-targeting factor for deubiquitinases like USP4 and USP15. Recruits USP4 to ubiquitinated PRPF3 within the U4/U5/U6 tri-snRNP complex, promoting PRPF3 deubiquitination and thereby regulating the spliceosome U4/U5/U6 tri-snRNP spliceosomal complex disassembly (PubMed:20595234). May also recruit the deubiquitinase USP15 to histone H2B and mediate histone deubiquitination, thereby regulating gene expression and/or DNA repair (PubMed:24526689). May play a role in hematopoiesis probably through transcription regulation of specific genes including MYC (By similarity). {ECO:0000250|UniProtKB:Q9JLI8, ECO:0000269|PubMed:12032085, ECO:0000269|PubMed:14749385, ECO:0000269|PubMed:20595234, ECO:0000269|PubMed:24526689}.; FUNCTION: Regulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1 gene expression and viral replication. {ECO:0000269|PubMed:11959860}. |
| Q16825 | PTPN21 | S820 | ochoa | Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1) | None |
| Q52LW3 | ARHGAP29 | S1019 | ochoa | Rho GTPase-activating protein 29 (PTPL1-associated RhoGAP protein 1) (Rho-type GTPase-activating protein 29) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis. {ECO:0000269|PubMed:15752761, ECO:0000269|PubMed:9305890}. |
| Q53F19 | NCBP3 | S446 | ochoa | Nuclear cap-binding protein subunit 3 (Protein ELG) | Associates with NCBP1/CBP80 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export. The alternative CBC is particularly important in cellular stress situations such as virus infections and the NCBP3 activity is critical to inhibit virus growth (PubMed:26382858). {ECO:0000269|PubMed:26382858}. |
| Q562F6 | SGO2 | S1140 | ochoa | Shugoshin 2 (Shugoshin-2) (Shugoshin-like 2) (Tripin) | Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments. Involved in centromeric enrichment of AUKRB in prometaphase. {ECO:0000250, ECO:0000269|PubMed:16541025, ECO:0000269|PubMed:17485487, ECO:0000269|PubMed:20739936}. |
| Q5SSJ5 | HP1BP3 | S377 | ochoa | Heterochromatin protein 1-binding protein 3 (Protein HP1-BP74) | Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity (PubMed:24830416). Mediates chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo-resistance and self-renewal (PubMed:25100860). {ECO:0000269|PubMed:24830416, ECO:0000269|PubMed:25100860}. |
| Q5VST9 | OBSCN | S7450 | ochoa | Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) | Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). {ECO:0000250|UniProtKB:A2AAJ9, ECO:0000269|PubMed:11448995, ECO:0000269|PubMed:16205939, ECO:0000269|PubMed:28826662}. |
| Q5W0Q7 | USPL1 | S561 | ochoa | SUMO-specific isopeptidase USPL1 (EC 3.4.22.-) (Ubiquitin-specific peptidase-like protein 1) (USP-like 1) | SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a higher affinity for SUMO2 and SUMO3 which it cleaves more efficiently. Also able to process full-length SUMO proteins to their mature forms (PubMed:22878415). Plays a key role in RNA polymerase-II-mediated snRNA transcription in the Cajal bodies (PubMed:24413172). Is a component of complexes that can bind to U snRNA genes (PubMed:24413172). {ECO:0000269|PubMed:22878415, ECO:0000269|PubMed:24413172}. |
| Q66K89 | E4F1 | S216 | ochoa | Transcription factor E4F1 (EC 2.3.2.27) (E4F transcription factor 1) (Putative E3 ubiquitin-protein ligase E4F1) (RING-type E3 ubiquitin transferase E4F1) (Transcription factor E4F) (p120E4F) (p50E4F) | May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating ubiquitination of chromatin-associated TP53. Functions in cell survival and proliferation through control of the cell cycle. Functions in the p53 and pRB tumor suppressor pathways and regulates the cyclin CCNA2 transcription.; FUNCTION: Identified as a cellular target of the adenoviral oncoprotein E1A, it is required for both transcriptional activation and repression of viral genes. |
| Q68DK7 | MSL1 | S401 | ochoa | Male-specific lethal 1 homolog (MSL-1) (Male-specific lethal 1-like 1) (MSL1-like 1) (Male-specific lethal-1 homolog 1) | Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:16227571, PubMed:16543150, PubMed:33837287). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). Within the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation (PubMed:22547026). Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) (PubMed:21726816, PubMed:30930284). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (PubMed:21726816). {ECO:0000250|UniProtKB:Q6PDM1, ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:21726816, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:30930284, ECO:0000269|PubMed:33837287}. |
| Q6DN90 | IQSEC1 | S198 | ochoa | IQ motif and SEC7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein) (BRAG2) | Guanine nucleotide exchange factor for ARF1 and ARF6 (PubMed:11226253, PubMed:24058294). Guanine nucleotide exchange factor activity is enhanced by lipid binding (PubMed:24058294). Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalization of beta-1 integrin (PubMed:16461286). Involved in neuronal development (Probable). In neurons, plays a role in the control of vesicle formation by endocytoc cargo. Upon long term depression, interacts with GRIA2 and mediates the activation of ARF6 to internalize synaptic AMPAR receptors (By similarity). {ECO:0000250|UniProtKB:A0A0G2JUG7, ECO:0000269|PubMed:11226253, ECO:0000269|PubMed:16461286, ECO:0000269|PubMed:24058294, ECO:0000305|PubMed:31607425}. |
| Q6PDB4 | ZNF880 | S421 | ochoa | Zinc finger protein 880 | None |
| Q6U7Q0 | ZNF322 | S224 | psp | Zinc finger protein 322 (Zinc finger protein 322A) (Zinc finger protein 388) (Zinc finger protein 489) | Transcriptional activator (PubMed:15555580). Important for maintenance of pluripotency in embryonic stem cells (By similarity). Binds directly to the POU5F1 distal enhancer and the NANOG proximal promoter, and enhances expression of both genes (By similarity). Can also bind to numerous other gene promoters and regulates expression of many other pluripotency factors, either directly or indirectly (By similarity). Promotes inhibition of MAPK signaling during embryonic stem cell differentiation (By similarity). {ECO:0000250|UniProtKB:Q8BZ89, ECO:0000269|PubMed:15555580}. |
| Q6UB98 | ANKRD12 | S1166 | ochoa | Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein) | May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation. |
| Q6UX73 | C16orf89 | S173 | ochoa | UPF0764 protein C16orf89 | None |
| Q6UXG2 | ELAPOR1 | S990 | ochoa | Endosome/lysosome-associated apoptosis and autophagy regulator 1 (Estrogen-induced gene 121 protein) | May protect cells from cell death by inducing cytosolic vacuolization and up-regulating the autophagy pathway (PubMed:21072319). May play a role in apoptosis and cell proliferation through its interaction with HSPA5 (PubMed:26045166). {ECO:0000269|PubMed:21072319, ECO:0000269|PubMed:26045166}. |
| Q6WKZ4 | RAB11FIP1 | S280 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
| Q7L4I2 | RSRC2 | S348 | ochoa | Arginine/serine-rich coiled-coil protein 2 | None |
| Q7Z3J3 | RGPD4 | S1543 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q86V48 | LUZP1 | S608 | ochoa | Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin) | F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250|UniProtKB:Q8R4U7, ECO:0000269|PubMed:30990684, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:38009294, ECO:0000269|PubMed:38832964}. |
| Q86YS3 | RAB11FIP4 | S304 | ochoa | Rab11 family-interacting protein 4 (FIP4-Rab11) (Rab11-FIP4) (Arfophilin-2) | Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abscission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. In case of infection by HCMV (human cytomegalovirus), may participate in egress of the virus out of nucleus; this function is independent of ARF6. {ECO:0000269|PubMed:12470645}. |
| Q8IWZ3 | ANKHD1 | S1658 | ochoa | Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) | May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases. {ECO:0000269|PubMed:16098192}. |
| Q8IXS8 | HYCC2 | S416 | ochoa | Hyccin 2 | Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. {ECO:0000305|PubMed:26571211}. |
| Q8N5A5 | ZGPAT | S373 | ochoa | Zinc finger CCCH-type with G patch domain-containing protein (G patch domain-containing protein 6) (Zinc finger CCCH domain-containing protein 9) (Zinc finger and G patch domain-containing protein) | Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis. {ECO:0000269|PubMed:19644445}.; FUNCTION: [Isoform 4]: Antagonizes the transcription repression by isoform 1 by competing for the binding of the NuRD complex. Does not bind DNA. {ECO:0000269|PubMed:19644445}. |
| Q8N9B5 | JMY | S854 | ochoa | Junction-mediating and -regulatory protein | Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions (PubMed:30420355). In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments (PubMed:30420355). Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments (PubMed:30420355). Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. Upon nutrient stress, directly recruited by MAP1LC3B to the phagophore membrane surfaces to promote actin assembly during autophagy (PubMed:30420355). The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location (By similarity). {ECO:0000250|UniProtKB:Q9QXM1, ECO:0000269|PubMed:30420355}. |
| Q8NA03 | FSIP1 | S338 | ochoa | Fibrous sheath-interacting protein 1 | None |
| Q8NAA4 | ATG16L2 | S276 | ochoa | Protein Atg16l2 (APG16-like 2) (Autophagy-related protein 16-2) (WD repeat-containing protein 80) | May play a role in regulating epithelial homeostasis in an ATG16L1-dependent manner. {ECO:0000250|UniProtKB:Q6KAU8}. |
| Q8NB49 | ATP11C | S445 | ochoa | Phospholipid-transporting ATPase IG (EC 7.6.2.1) (ATPase IQ) (ATPase class VI type 11C) (P4-ATPase flippase complex alpha subunit ATP11C) | Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of the plasma membrane (PubMed:24904167, PubMed:25315773, PubMed:26567335, PubMed:32493773). Major PS-flippase in immune cell subsets. In erythrocyte plasma membrane, it is required to maintain PS in the inner leaflet preventing its exposure on the surface. This asymmetric distribution is critical for the survival of erythrocytes in circulation since externalized PS is a phagocytic signal for erythrocyte clearance by splenic macrophages (PubMed:26944472). Required for B cell differentiation past the pro-B cell stage (By similarity). Seems to mediate PS flipping in pro-B cells (By similarity). May be involved in the transport of cholestatic bile acids (By similarity). {ECO:0000250|UniProtKB:Q9QZW0, ECO:0000269|PubMed:24904167, ECO:0000269|PubMed:25315773, ECO:0000269|PubMed:26944472, ECO:0000269|PubMed:32493773}. |
| Q8NEV8 | EXPH5 | S318 | ochoa | Exophilin-5 (Synaptotagmin-like protein homolog lacking C2 domains b) (SlaC2-b) (Slp homolog lacking C2 domains b) | May act as Rab effector protein and play a role in vesicle trafficking. |
| Q8NFU5 | IPMK | S348 | ochoa | Inositol polyphosphate multikinase (EC 2.7.1.140) (EC 2.7.1.151) (EC 2.7.1.153) (Inositol 1,3,4,6-tetrakisphosphate 5-kinase) | Inositol phosphate kinase with a broad substrate specificity (PubMed:12027805, PubMed:12223481, PubMed:28882892, PubMed:30420721, PubMed:30624931). Phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) first to inositol 1,3,4,5-tetrakisphosphate and then to inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) (PubMed:12027805, PubMed:12223481, PubMed:28882892, PubMed:30624931). Phosphorylates inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4) (PubMed:12223481). Phosphorylates inositol 1,4,5,6-tetrakisphosphate (Ins(1,4,5,6)P4) (By similarity). Phosphorylates glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate to glycero-3-phospho-1D-myo-inositol 3,4,5-trisphosphate (PubMed:28882892, PubMed:30420721). Plays an important role in MLKL-mediated necroptosis via its role in the biosynthesis of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Binding of these highly phosphorylated inositol phosphates to MLKL mediates the release of an N-terminal auto-inhibitory region, leading to activation of the kinase. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis (PubMed:29883610). Required for normal embryonic development, probably via its role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) and inositol hexakisphosphate (InsP6) (By similarity). {ECO:0000250|UniProtKB:Q7TT16, ECO:0000269|PubMed:12027805, ECO:0000269|PubMed:12223481, ECO:0000269|PubMed:28882892, ECO:0000269|PubMed:29883610, ECO:0000269|PubMed:30420721, ECO:0000269|PubMed:30624931}. |
| Q8NG31 | KNL1 | S685 | ochoa | Outer kinetochore KNL1 complex subunit KNL1 (ALL1-fused gene from chromosome 15q14 protein) (AF15q14) (Bub-linking kinetochore protein) (Blinkin) (Cancer susceptibility candidate gene 5 protein) (Cancer/testis antigen 29) (CT29) (Kinetochore scaffold 1) (Kinetochore-null protein 1) (Protein CASC5) (Protein D40/AF15q14) | Acts as a component of the outer kinetochore KNL1 complex that serves as a docking point for spindle assembly checkpoint components and mediates microtubule-kinetochore interactions (PubMed:15502821, PubMed:17981135, PubMed:18045986, PubMed:19893618, PubMed:21199919, PubMed:22000412, PubMed:22331848, PubMed:27881301, PubMed:30100357). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules (PubMed:18045986, PubMed:19893618, PubMed:27881301). The outer kinetochore is made up of the ten-subunit KMN network, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:38459127, PubMed:38459128). Required for kinetochore binding by a distinct subset of kMAPs (kinetochore-bound microtubule-associated proteins) and motors (PubMed:19893618). Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore (PubMed:18045986, PubMed:27881301). Can bind either to microtubules or to the protein phosphatase 1 (PP1) catalytic subunits PPP1CA and PPP1CC (via overlapping binding sites), it has higher affinity for PP1 (PubMed:30100357). Recruits MAD2L1 to the kinetochore and also directly links BUB1 and BUB1B to the kinetochore (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:22331848, PubMed:25308863). In addition to orienting mitotic chromosomes, it is also essential for alignment of homologous chromosomes during meiotic metaphase I (By similarity). In meiosis I, required to activate the spindle assembly checkpoint at unattached kinetochores to correct erroneous kinetochore-microtubule attachments (By similarity). {ECO:0000250|UniProtKB:Q66JQ7, ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:17981135, ECO:0000269|PubMed:18045986, ECO:0000269|PubMed:19893618, ECO:0000269|PubMed:21199919, ECO:0000269|PubMed:22000412, ECO:0000269|PubMed:22331848, ECO:0000269|PubMed:25308863, ECO:0000269|PubMed:27881301, ECO:0000269|PubMed:30100357, ECO:0000269|PubMed:38459127, ECO:0000269|PubMed:38459128}. |
| Q8NHU6 | TDRD7 | S571 | ochoa | Tudor domain-containing protein 7 (PCTAIRE2-binding protein) (Tudor repeat associator with PCTAIRE-2) (Trap) | Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis. {ECO:0000269|PubMed:21436445}. |
| Q92613 | JADE3 | S650 | ochoa | Protein Jade-3 (Jade family PHD finger protein 3) (PHD finger protein 16) | Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity. {ECO:0000269|PubMed:16387653}. |
| Q92731 | ESR2 | S200 | psp | Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2) | Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560). {ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:29261182, ECO:0000269|PubMed:30113650, ECO:0000269|PubMed:9325313}.; FUNCTION: [Isoform 2]: Lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability. {ECO:0000269|PubMed:9671811}. |
| Q92854 | SEMA4D | S833 | ochoa | Semaphorin-4D (A8) (BB18) (GR3) (CD antigen CD100) | Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling (PubMed:20877282). Regulates GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity). Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (PubMed:19788569). Promotes the migration of cerebellar granule cells (PubMed:16055703). Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro) (PubMed:8876214). Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway (PubMed:16055703). {ECO:0000250|UniProtKB:O09126, ECO:0000269|PubMed:16055703, ECO:0000269|PubMed:19788569, ECO:0000269|PubMed:20877282, ECO:0000269|PubMed:8876214}. |
| Q96EY5 | MVB12A | S163 | psp | Multivesicular body subunit 12A (CIN85/CD2AP family-binding protein) (ESCRT-I complex subunit MVB12A) (Protein FAM125A) | Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down-regulation of EGF receptor. {ECO:0000269|PubMed:16895919}. |
| Q96FX7 | TRMT61A | S46 | ochoa | tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A (EC 2.1.1.220) (mRNA methyladenosine-N(1)-methyltransferase catalytic subunit TRMT61A) (EC 2.1.1.-) (tRNA(m1A58)-methyltransferase subunit TRMT61A) (tRNA(m1A58)MTase subunit TRMT61A) | Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA (PubMed:16043508). Catalytic subunit of mRNA N(1)-methyltransferase complex, which mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries (PubMed:29072297, PubMed:29107537). {ECO:0000269|PubMed:16043508, ECO:0000269|PubMed:29072297, ECO:0000269|PubMed:29107537}. |
| Q96I24 | FUBP3 | S162 | ochoa | Far upstream element-binding protein 3 (FUSE-binding protein 3) | May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. |
| Q96Q15 | SMG1 | S34 | ochoa | Serine/threonine-protein kinase SMG1 (SMG-1) (hSMG-1) (EC 2.7.11.1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (Nonsense mediated mRNA decay-associated PI3K-related kinase SMG1) | Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ. {ECO:0000269|PubMed:11331269, ECO:0000269|PubMed:11544179, ECO:0000269|PubMed:15175154, ECO:0000269|PubMed:16452507}. |
| Q96QB1 | DLC1 | S673 | ochoa | Rho GTPase-activating protein 7 (Deleted in liver cancer 1 protein) (DLC-1) (HP protein) (Rho-type GTPase-activating protein 7) (START domain-containing protein 12) (StARD12) (StAR-related lipid transfer protein 12) | Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality. Required for growth factor-induced epithelial cell migration; in resting cells, interacts with TNS3 while PTEN interacts with the p85 regulatory subunit of the PI3K kinase complex but growth factor stimulation induces phosphorylation of TNS3 and PTEN, causing them to change their binding preference so that PTEN interacts with DLC1 and TNS3 interacts with p85 (PubMed:26166433). The PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA while the TNS3-p85 complex translocates to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). {ECO:0000269|PubMed:18786931, ECO:0000269|PubMed:19170769, ECO:0000269|PubMed:19710422, ECO:0000269|PubMed:26166433}. |
| Q96SN8 | CDK5RAP2 | S843 | ochoa | CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215) | Potential regulator of CDK5 activity via its interaction with CDK5R1 (PubMed:15164053). Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter (PubMed:19282672). Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends (PubMed:18042621, PubMed:17959831, PubMed:19553473). Regulates centrosomal maturation by recruitment of the gamma-tubulin ring complex (gTuRC) onto centrosomes (PubMed:18042621, PubMed:17959831, PubMed:26485573, PubMed:39321809). In complex with PDE4DIP isoform 13/MMG8/SMYLE, MAPRE1 and AKAP9, contributes to microtubules nucleation and extension from the centrosome to the cell periphery (PubMed:29162697). Required for the recruitment of AKAP9 to centrosomes (PubMed:29162697). Plays a role in neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q8K389, ECO:0000269|PubMed:15164053, ECO:0000269|PubMed:17959831, ECO:0000269|PubMed:18042621, ECO:0000269|PubMed:19282672, ECO:0000269|PubMed:19553473, ECO:0000269|PubMed:26485573, ECO:0000269|PubMed:29162697, ECO:0000269|PubMed:39321809}. |
| Q96T23 | RSF1 | S1391 | ochoa | Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex) | Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:12972596, PubMed:28801535). Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively (PubMed:28801535). The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex (PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11788598, PubMed:11944984). {ECO:0000269|PubMed:11788598, ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:28801535}. |
| Q96T23 | RSF1 | S1398 | ochoa | Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex) | Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:12972596, PubMed:28801535). Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively (PubMed:28801535). The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex (PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11788598, PubMed:11944984). {ECO:0000269|PubMed:11788598, ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:28801535}. |
| Q99490 | AGAP2 | S750 | ochoa | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP-2) (Centaurin-gamma-1) (Cnt-g1) (GTP-binding and GTPase-activating protein 2) (GGAP2) (Phosphatidylinositol 3-kinase enhancer) (PIKE) | GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion. {ECO:0000269|PubMed:12640130, ECO:0000269|PubMed:14761976, ECO:0000269|PubMed:15118108, ECO:0000269|PubMed:16079295}. |
| Q99549 | MPHOSPH8 | S371 | ochoa | M-phase phosphoprotein 8 (Two hybrid-associated protein 3 with RanBPM) (Twa3) | Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416). Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene (PubMed:20871592). Mediates down-regulation of CDH1 expression (PubMed:20871592). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). {ECO:0000269|PubMed:20871592, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}. |
| Q9BTA9 | WAC | S22 | ochoa | WW domain-containing adapter protein with coiled-coil | Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1) (PubMed:21329877). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription (PubMed:21329877). Regulates the cell-cycle checkpoint activation in response to DNA damage (PubMed:21329877). Positive regulator of amino acid starvation-induced autophagy (PubMed:22354037). Also acts as a negative regulator of basal autophagy (PubMed:26812014). Positively regulates MTOR activity by promoting, in an energy-dependent manner, the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex. This leads to the dimerization of the mTORC1 complex and its subsequent activation (PubMed:26812014). May negatively regulate the ubiquitin proteasome pathway (PubMed:21329877). {ECO:0000269|PubMed:21329877, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:26812014}. |
| Q9BTV4 | TMEM43 | S21 | ochoa | Transmembrane protein 43 (Protein LUMA) | May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane (By similarity). Plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26 (PubMed:32614325). In addition, functions as a critical signaling component in mediating NF-kappa-B activation by acting downstream of EGFR and upstream of CARD10 (PubMed:27991920). Contributes to passive conductance current in cochlear glia-like supporting cells, mediated by gap junctions and necessary for hearing and speech discrimination (PubMed:34050020). {ECO:0000250|UniProtKB:Q9DBS1, ECO:0000269|PubMed:27991920, ECO:0000269|PubMed:32614325, ECO:0000269|PubMed:34050020}. |
| Q9BWU0 | SLC4A1AP | S709 | ochoa | Kanadaptin (Human lung cancer oncogene 3 protein) (HLC-3) (Kidney anion exchanger adapter protein) (Solute carrier family 4 anion exchanger member 1 adapter protein) | None |
| Q9C0B0 | UNK | S546 | psp | RING finger protein unkempt homolog (Zinc finger CCCH domain-containing protein 5) | Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280). {ECO:0000269|PubMed:25737280}. |
| Q9H8K7 | PAAT | S302 | ochoa | ATPase PAAT (EC 3.6.1.-) (Protein associated with ABC transporters) (PAAT) | ATPase that regulates mitochondrial ABC transporters ABCB7, ABCB8/MITOSUR and ABCB10 (PubMed:25063848). Regulates mitochondrial ferric concentration and heme biosynthesis and plays a role in the maintenance of mitochondrial homeostasis and cell survival (PubMed:25063848). {ECO:0000269|PubMed:25063848}. |
| Q9HB21 | PLEKHA1 | S129 | ochoa | Pleckstrin homology domain-containing family A member 1 (PH domain-containing family A member 1) (Tandem PH domain-containing protein 1) (TAPP-1) | Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane. {ECO:0000269|PubMed:11001876, ECO:0000269|PubMed:11513726, ECO:0000269|PubMed:14516276}. |
| Q9HBI1 | PARVB | S254 | ochoa | Beta-parvin (Affixin) | Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration. {ECO:0000269|PubMed:11402068, ECO:0000269|PubMed:15005707, ECO:0000269|PubMed:15159419, ECO:0000269|PubMed:15284246, ECO:0000269|PubMed:18325335}. |
| Q9HCE6 | ARHGEF10L | S708 | ochoa | Rho guanine nucleotide exchange factor 10-like protein (GrinchGEF) | Acts as a guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC. {ECO:0000269|PubMed:16112081}. |
| Q9HD42 | CHMP1A | S67 | ochoa | Charged multivesicular body protein 1a (Chromatin-modifying protein 1a) (CHMP1a) (Vacuolar protein sorting-associated protein 46-1) (Vps46-1) (hVps46-1) | Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing. {ECO:0000269|PubMed:11559747, ECO:0000269|PubMed:11559748, ECO:0000269|PubMed:19129479, ECO:0000269|PubMed:23045692}. |
| Q9NRM7 | LATS2 | S835 | psp | Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase) | Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:18158288, PubMed:26437443, PubMed:26598551, PubMed:34404733). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:26437443, PubMed:26598551, PubMed:34404733). Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:26598551, PubMed:34404733). Also phosphorylates YAP1 in response to cell contact inhibition-driven WWP1 ubiquitination of AMOTL2, which results in LATS2 activation (PubMed:34404733). Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability (PubMed:10871863). Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity (PubMed:12853976). Negative regulator of the androgen receptor (PubMed:15131260). Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities (PubMed:21952048). This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ (PubMed:21952048). Acts as an activator of the NLRP3 inflammasome by mediating phosphorylation of 'Ser-265' of NLRP3 following NLRP3 palmitoylation, promoting NLRP3 activation by NEK7 (PubMed:39173637). {ECO:0000269|PubMed:10871863, ECO:0000269|PubMed:12853976, ECO:0000269|PubMed:15131260, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:21952048, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:34404733, ECO:0000269|PubMed:39173637}. |
| Q9NVC6 | MED17 | S408 | ochoa | Mediator of RNA polymerase II transcription subunit 17 (Activator-recruited cofactor 77 kDa component) (ARC77) (Cofactor required for Sp1 transcriptional activation subunit 6) (CRSP complex subunit 6) (Mediator complex subunit 17) (Thyroid hormone receptor-associated protein complex 80 kDa component) (Trap80) (Transcriptional coactivator CRSP77) (Vitamin D3 receptor-interacting protein complex 80 kDa component) (DRIP80) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:16595664}. |
| Q9P270 | SLAIN2 | S35 | ochoa | SLAIN motif-containing protein 2 | Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase. {ECO:0000269|PubMed:21646404}. |
| Q9UI36 | DACH1 | S581 | psp | Dachshund homolog 1 (Dach1) | Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation also seems to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By similarity). {ECO:0000250, ECO:0000269|PubMed:14525983}. |
| Q9UK61 | TASOR | S344 | ochoa | Protein TASOR (CTCL tumor antigen se89-1) (Retinoblastoma-associated protein RAP140) (Transgene activation suppressor protein) | Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression (PubMed:26022416, PubMed:28581500). The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Plays a crucial role in early embryonic development (By similarity). Involved in the organization of spindle poles and spindle apparatus assembly during zygotic division (By similarity). Plays an important role in maintaining epiblast fitness or potency (By similarity). {ECO:0000250|UniProtKB:Q69ZR9, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}. |
| Q9ULM0 | PLEKHH1 | S566 | ochoa | Pleckstrin homology domain-containing family H member 1 (PH domain-containing family H member 1) | None |
| Q9Y250 | LZTS1 | S231 | ochoa | Leucine zipper putative tumor suppressor 1 (F37/esophageal cancer-related gene-coding leucine-zipper motif) (Fez1) | Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor. {ECO:0000269|PubMed:10097140, ECO:0000269|PubMed:11464283, ECO:0000269|PubMed:11504921}. |
| Q9Y2F5 | ICE1 | S1040 | ochoa | Little elongation complex subunit 1 (Interactor of little elongator complex ELL subunit 1) | Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780). {ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23932780}. |
| Q9Y2X7 | GIT1 | S54 | psp | ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) (p95-APP1) | GTPase-activating protein for ADP ribosylation factor family members, including ARF1. Multidomain scaffold protein that interacts with numerous proteins and therefore participates in many cellular functions, including receptor internalization, focal adhesion remodeling, and signaling by both G protein-coupled receptors and tyrosine kinase receptors (By similarity). Through PAK1 activation, positively regulates microtubule nucleation during interphase (PubMed:27012601). Plays a role in the regulation of cytokinesis; for this function, may act in a pathway also involving ENTR1 and PTPN13 (PubMed:23108400). May promote cell motility both by regulating focal complex dynamics and by local activation of RAC1 (PubMed:10938112, PubMed:11896197). May act as scaffold for MAPK1/3 signal transduction in focal adhesions. Recruits MAPK1/3/ERK1/2 to focal adhesions after EGF stimulation via a Src-dependent pathway, hence stimulating cell migration (PubMed:15923189). Plays a role in brain development and function. Involved in the regulation of spine density and synaptic plasticity that is required for processes involved in learning (By similarity). Plays an important role in dendritic spine morphogenesis and synapse formation (PubMed:12695502, PubMed:15800193). In hippocampal neurons, recruits guanine nucleotide exchange factors (GEFs), such as ARHGEF7/beta-PIX, to the synaptic membrane. These in turn locally activate RAC1, which is an essential step for spine morphogenesis and synapse formation (PubMed:12695502). May contribute to the organization of presynaptic active zones through oligomerization and formation of a Piccolo/PCLO-based protein network, which includes ARHGEF7/beta-PIX and FAK1 (By similarity). In neurons, through its interaction with liprin-alpha family members, may be required for AMPA receptor (GRIA2/3) proper targeting to the cell membrane (By similarity). In complex with GABA(A) receptors and ARHGEF7, plays a crucial role in regulating GABA(A) receptor synaptic stability, maintaining GPHN/gephyrin scaffolds and hence GABAergic inhibitory synaptic transmission, by locally coordinating RAC1 and PAK1 downstream effector activity, leading to F-actin stabilization (PubMed:25284783). May also be important for RAC1 downstream signaling pathway through PAK3 and regulation of neuronal inhibitory transmission at presynaptic input (By similarity). Required for successful bone regeneration during fracture healing (By similarity). The function in intramembranous ossification may, at least partly, exerted by macrophages in which GIT1 is a key negative regulator of redox homeostasis, IL1B production, and glycolysis, acting through the ERK1/2/NRF2/NFE2L2 axis (By similarity). May play a role in angiogenesis during fracture healing (By similarity). In this process, may regulate activation of the canonical NF-kappa-B signal in bone mesenchymal stem cells by enhancing the interaction between NEMO and 'Lys-63'-ubiquitinated RIPK1/RIP1, eventually leading to enhanced production of VEGFA and others angiogenic factors (PubMed:31502302). Essential for VEGF signaling through the activation of phospholipase C-gamma and ERK1/2, hence may control endothelial cell proliferation and angiogenesis (PubMed:19273721). {ECO:0000250|UniProtKB:Q68FF6, ECO:0000250|UniProtKB:Q9Z272, ECO:0000269|PubMed:10938112, ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:12695502, ECO:0000269|PubMed:15800193, ECO:0000269|PubMed:15923189, ECO:0000269|PubMed:19273721, ECO:0000269|PubMed:23108400, ECO:0000269|PubMed:25284783, ECO:0000269|PubMed:27012601, ECO:0000269|PubMed:31502302}. |
| Q9Y3B7 | MRPL11 | S45 | ochoa | Large ribosomal subunit protein uL11m (39S ribosomal protein L11, mitochondrial) (L11mt) (MRP-L11) | None |
| Q9Y520 | PRRC2C | S376 | ochoa | Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) | Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}. |
| Q9Y616 | IRAK3 | S332 | ochoa | Interleukin-1 receptor-associated kinase 3 (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) (Inactive IL-1 receptor-associated kinase 3) | Putative inactive protein kinase which regulates signaling downstream of immune receptors including IL1R and Toll-like receptors (PubMed:10383454, PubMed:29686383). Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex (By similarity). Upon IL33-induced lung inflammation, positively regulates expression of IL6, CSF3, CXCL2 and CCL5 mRNAs in dendritic cells (PubMed:29686383). {ECO:0000250|UniProtKB:Q8K4B2, ECO:0000269|PubMed:10383454, ECO:0000269|PubMed:29686383}. |
| Q9Y6J0 | CABIN1 | S1375 | ochoa | Calcineurin-binding protein cabin-1 (Calcineurin inhibitor) (CAIN) | May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:9655484}. |
| Q9Y6T7 | DGKB | S420 | ochoa | Diacylglycerol kinase beta (DAG kinase beta) (EC 2.7.1.107) (90 kDa diacylglycerol kinase) (Diglyceride kinase beta) (DGK-beta) | Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:11719522). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Has a higher activity with long-chain diacylglycerols like 1,2-di-(9Z-octadecenoyl)-sn-glycerol compared to 1,2-didecanoyl-sn-glycerol (By similarity). Specifically expressed in brain, it regulates neuron-specific morphological changes including neurite branching and neurite spine formation (By similarity). {ECO:0000250|UniProtKB:P49621, ECO:0000250|UniProtKB:Q6NS52, ECO:0000269|PubMed:11719522, ECO:0000305}.; FUNCTION: [Isoform 2]: Does not associate with membranes but has a diacylglycerol kinase activity. {ECO:0000269|PubMed:11719522}. |
| V9GY48 | None | S259 | ochoa | Zinc finger CCCH-type with G patch domain-containing protein | None |
| P05787 | KRT8 | S404 | Sugiyama | Keratin, type II cytoskeletal 8 (Cytokeratin-8) (CK-8) (Keratin-8) (K8) (Type-II keratin Kb8) | Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. {ECO:0000269|PubMed:16000376}. |
| Q9Y2T3 | GDA | S263 | Sugiyama | Guanine deaminase (Guanase) (Guanine aminase) (EC 3.5.4.3) (Guanine aminohydrolase) (GAH) (p51-nedasin) | Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia. {ECO:0000269|PubMed:10075721, ECO:0000269|PubMed:22662200}. |
| O43781 | DYRK3 | S54 | Sugiyama | Dual specificity tyrosine-phosphorylation-regulated kinase 3 (EC 2.7.12.1) (Regulatory erythroid kinase) (REDK) | Dual-specificity protein kinase that promotes disassembly of several types of membraneless organelles during mitosis, such as stress granules, nuclear speckles and pericentriolar material (PubMed:29973724). Dual-specificity tyrosine-regulated kinases (DYRKs) autophosphorylate a critical tyrosine residue in their activation loop and phosphorylate their substrate on serine and threonine residues (PubMed:29634919, PubMed:9748265). Acts as a central dissolvase of membraneless organelles during the G2-to-M transition, after the nuclear-envelope breakdown: acts by mediating phosphorylation of multiple serine and threonine residues in unstructured domains of proteins, such as SRRM1 and PCM1 (PubMed:29973724). Does not mediate disassembly of all membraneless organelles: disassembly of P-body and nucleolus is not regulated by DYRK3 (PubMed:29973724). Dissolution of membraneless organelles at the onset of mitosis is also required to release mitotic regulators, such as ZNF207, from liquid-unmixed organelles where they are sequestered and keep them dissolved during mitosis (PubMed:29973724). Regulates mTORC1 by mediating the dissolution of stress granules: during stressful conditions, DYRK3 partitions from the cytosol to the stress granule, together with mTORC1 components, which prevents mTORC1 signaling (PubMed:23415227). When stress signals are gone, the kinase activity of DYRK3 is required for the dissolution of stress granule and mTORC1 relocation to the cytosol: acts by mediating the phosphorylation of the mTORC1 inhibitor AKT1S1, allowing full reactivation of mTORC1 signaling (PubMed:23415227). Also acts as a negative regulator of EPO-dependent erythropoiesis: may place an upper limit on red cell production during stress erythropoiesis (PubMed:10779429). Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells (PubMed:10779429). Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1: this in turn inhibits p53/TP53 activity and apoptosis (PubMed:20167603). {ECO:0000269|PubMed:10779429, ECO:0000269|PubMed:20167603, ECO:0000269|PubMed:23415227, ECO:0000269|PubMed:29634919, ECO:0000269|PubMed:29973724, ECO:0000269|PubMed:9748265}. |
| Q9P032 | NDUFAF4 | S35 | Sugiyama | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 (Hormone-regulated proliferation-associated protein of 20 kDa) | Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) (PubMed:18179882, PubMed:28853723). May be involved in cell proliferation and survival of hormone-dependent tumor cells. May be a regulator of breast tumor cell invasion. {ECO:0000269|PubMed:14871833, ECO:0000269|PubMed:17001319, ECO:0000269|PubMed:18179882, ECO:0000269|PubMed:28853723}. |
| Q96PZ0 | PUS7 | S53 | Sugiyama | Pseudouridylate synthase 7 homolog (EC 5.4.99.-) | Pseudouridylate synthase that catalyzes pseudouridylation of RNAs (PubMed:28073919, PubMed:29628141, PubMed:30778726, PubMed:31477916, PubMed:34718722, PubMed:35051350). Acts as a regulator of protein synthesis in embryonic stem cells by mediating pseudouridylation of RNA fragments derived from tRNAs (tRFs): pseudouridylated tRFs inhibit translation by targeting the translation initiation complex (PubMed:29628141). Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3' (PubMed:28073919, PubMed:31477916, PubMed:35051350). Acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions (PubMed:35051350). Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing (PubMed:35051350). In addition to mRNAs and tRNAs, binds other types of RNAs, such as snRNAs, Y RNAs and vault RNAs, suggesting that it can catalyze pseudouridylation of many RNA types (PubMed:29628141). {ECO:0000269|PubMed:28073919, ECO:0000269|PubMed:29628141, ECO:0000269|PubMed:30778726, ECO:0000269|PubMed:31477916, ECO:0000269|PubMed:34718722, ECO:0000269|PubMed:35051350}. |
| P22234 | PAICS | S213 | Sugiyama | Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) [Includes: Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) (AIR carboxylase) (AIRC); Phosphoribosylaminoimidazole succinocarboxamide synthetase (EC 6.3.2.6) (SAICAR synthetase)] | Bifunctional phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazole succinocarboxamide synthetase catalyzing two reactions of the de novo purine biosynthetic pathway. {ECO:0000269|PubMed:17224163, ECO:0000269|PubMed:2183217, ECO:0000269|PubMed:31600779}. |
| Q969U7 | PSMG2 | S166 | Sugiyama | Proteasome assembly chaperone 2 (PAC-2) (Hepatocellular carcinoma-susceptibility protein 3) (Tumor necrosis factor superfamily member 5-induced protein 1) | Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization. {ECO:0000269|PubMed:16251969, ECO:0000269|PubMed:17707236}. |
| Q05513 | PRKCZ | S148 | Sugiyama | Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta) | Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its kinase activity and can activate JUN promoter through MEF2C. Through binding with SQSTM1/p62, functions in interleukin-1 signaling and activation of NF-kappa-B with the specific adapters RIPK1 and TRAF6. Participates in TNF-dependent transactivation of NF-kappa-B by phosphorylating and activating IKBKB kinase, which in turn leads to the degradation of NF-kappa-B inhibitors. In migrating astrocytes, forms a cytoplasmic complex with PARD6A and is recruited by CDC42 to function in the establishment of cell polarity along with the microtubule motor and dynein. In association with FEZ1, stimulates neuronal differentiation in PC12 cells. In the inflammatory response, is required for the T-helper 2 (Th2) differentiation process, including interleukin production, efficient activation of JAK1 and the subsequent phosphorylation and nuclear translocation of STAT6. May be involved in development of allergic airway inflammation (asthma), a process dependent on Th2 immune response. In the NF-kappa-B-mediated inflammatory response, can relieve SETD6-dependent repression of NF-kappa-B target genes by phosphorylating the RELA subunit at 'Ser-311'. Phosphorylates VAMP2 in vitro (PubMed:17313651). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000269|PubMed:11035106, ECO:0000269|PubMed:12162751, ECO:0000269|PubMed:15084291, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:17313651, ECO:0000269|PubMed:36040231, ECO:0000269|PubMed:9447975}.; FUNCTION: [Isoform 2]: Involved in late synaptic long term potention phase in CA1 hippocampal cells and long term memory maintenance. {ECO:0000250|UniProtKB:Q02956}. |
| Q16288 | NTRK3 | S706 | Sugiyama | NT-3 growth factor receptor (EC 2.7.10.1) (GP145-TrkC) (Trk-C) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) | Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation. {ECO:0000269|PubMed:25196463}. |
| P06733 | ENO1 | S104 | Sugiyama | Alpha-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (C-myc promoter-binding protein) (Enolase 1) (MBP-1) (MPB-1) (Non-neural enolase) (NNE) (Phosphopyruvate hydratase) (Plasminogen-binding protein) | Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (PubMed:1369209, PubMed:29775581). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses (PubMed:10802057, PubMed:12666133, PubMed:2005901, PubMed:29775581). May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (PubMed:12666133). Stimulates immunoglobulin production (PubMed:1369209). {ECO:0000269|PubMed:10802057, ECO:0000269|PubMed:12666133, ECO:0000269|PubMed:1369209, ECO:0000269|PubMed:2005901, ECO:0000269|PubMed:29775581}.; FUNCTION: [Isoform MBP-1]: Binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor. {ECO:0000269|PubMed:10082554}. |
| Q14566 | MCM6 | S341 | Sugiyama | DNA replication licensing factor MCM6 (EC 3.6.4.12) (p105MCM) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). {ECO:0000269|PubMed:16899510, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9305914}. |
| Q9HBH9 | MKNK2 | S338 | Sugiyama | MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (MAPK signal-integrating kinase 2) (Mnk2) | Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal. {ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:11463832, ECO:0000269|PubMed:12897141, ECO:0000269|PubMed:16111636, ECO:0000269|PubMed:17965020, ECO:0000269|PubMed:18299328, ECO:0000269|PubMed:20823271, ECO:0000269|PubMed:20927323, ECO:0000269|PubMed:21149447}. |
| Q9NWZ3 | IRAK4 | S186 | Sugiyama | Interleukin-1 receptor-associated kinase 4 (IRAK-4) (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-64) | Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways (PubMed:17878374). Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections. {ECO:0000269|PubMed:11960013, ECO:0000269|PubMed:12538665, ECO:0000269|PubMed:15084582, ECO:0000269|PubMed:17217339, ECO:0000269|PubMed:17337443, ECO:0000269|PubMed:17878374, ECO:0000269|PubMed:17997719, ECO:0000269|PubMed:20400509, ECO:0000269|PubMed:24316379}. |
| Q9P2K8 | EIF2AK4 | S467 | Sugiyama | eIF-2-alpha kinase GCN2 (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 4) (GCN2-like protein) | Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to low amino acid availability (PubMed:25329545, PubMed:32610081). Plays a role as an activator of the integrated stress response (ISR) required for adaptation to amino acid starvation (By similarity). EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha into a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, and thus to a reduced overall utilization of amino acids, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion (PubMed:32610081). Binds uncharged tRNAs (By similarity). Required for the translational induction of protein kinase PRKCH following amino acid starvation (By similarity). Involved in cell cycle arrest by promoting cyclin D1 mRNA translation repression after the unfolded protein response pathway (UPR) activation or cell cycle inhibitor CDKN1A/p21 mRNA translation activation in response to amino acid deprivation (PubMed:26102367). Plays a role in the consolidation of synaptic plasticity, learning as well as formation of long-term memory (By similarity). Plays a role in neurite outgrowth inhibition (By similarity). Plays a proapoptotic role in response to glucose deprivation (By similarity). Promotes global cellular protein synthesis repression in response to UV irradiation independently of the stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) and p38 MAPK signaling pathways (By similarity). Plays a role in the antiviral response against alphavirus infection; impairs early viral mRNA translation of the incoming genomic virus RNA, thus preventing alphavirus replication (By similarity). {ECO:0000250|UniProtKB:P15442, ECO:0000250|UniProtKB:Q9QZ05, ECO:0000269|PubMed:25329545, ECO:0000269|PubMed:26102367, ECO:0000269|PubMed:32610081}.; FUNCTION: (Microbial infection) Plays a role in modulating the adaptive immune response to yellow fever virus infection; promotes dendritic cells to initiate autophagy and antigene presentation to both CD4(+) and CD8(+) T-cells under amino acid starvation (PubMed:24310610). {ECO:0000269|PubMed:24310610}. |
| Q9Y4K4 | MAP4K5 | S421 | Sugiyama | Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (Kinase homologous to SPS1/STE20) (KHS) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) | May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. {ECO:0000269|PubMed:9038372}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-383280 | Nuclear Receptor transcription pathway | 5.833710e-09 | 8.234 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 3.026340e-06 | 5.519 |
| R-HSA-5661231 | Metallothioneins bind metals | 3.743060e-05 | 4.427 |
| R-HSA-5660526 | Response to metal ions | 1.063008e-04 | 3.973 |
| R-HSA-196025 | Formation of annular gap junctions | 2.874836e-04 | 3.541 |
| R-HSA-190873 | Gap junction degradation | 3.701514e-04 | 3.432 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 7.666138e-04 | 3.115 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 7.666138e-04 | 3.115 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 8.488230e-04 | 3.071 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 1.296492e-03 | 2.887 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 1.777180e-03 | 2.750 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 2.651411e-03 | 2.577 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 2.720192e-03 | 2.565 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 5.897754e-03 | 2.229 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 7.083796e-03 | 2.150 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 7.083796e-03 | 2.150 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 6.474897e-03 | 2.189 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 4.614811e-03 | 2.336 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 4.354391e-03 | 2.361 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 6.901486e-03 | 2.161 |
| R-HSA-2467813 | Separation of Sister Chromatids | 4.962864e-03 | 2.304 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 7.083796e-03 | 2.150 |
| R-HSA-2682334 | EPH-Ephrin signaling | 6.375841e-03 | 2.195 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 4.949091e-03 | 2.305 |
| R-HSA-69620 | Cell Cycle Checkpoints | 4.677283e-03 | 2.330 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 6.466147e-03 | 2.189 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 4.120779e-03 | 2.385 |
| R-HSA-9828806 | Maturation of hRSV A proteins | 6.474897e-03 | 2.189 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 8.343562e-03 | 2.079 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 9.308215e-03 | 2.031 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 8.832433e-03 | 2.054 |
| R-HSA-8939211 | ESR-mediated signaling | 9.358210e-03 | 2.029 |
| R-HSA-68877 | Mitotic Prometaphase | 1.093480e-02 | 1.961 |
| R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 1.278994e-02 | 1.893 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 1.340651e-02 | 1.873 |
| R-HSA-163560 | Triglyceride catabolism | 1.320130e-02 | 1.879 |
| R-HSA-162582 | Signal Transduction | 1.361192e-02 | 1.866 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 1.402918e-02 | 1.853 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 1.577175e-02 | 1.802 |
| R-HSA-1475029 | Reversible hydration of carbon dioxide | 1.618840e-02 | 1.791 |
| R-HSA-5674135 | MAP2K and MAPK activation | 1.860407e-02 | 1.730 |
| R-HSA-68882 | Mitotic Anaphase | 1.856430e-02 | 1.731 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 1.771973e-02 | 1.752 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 1.894677e-02 | 1.722 |
| R-HSA-437239 | Recycling pathway of L1 | 2.506051e-02 | 1.601 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 2.115519e-02 | 1.675 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 2.391099e-02 | 1.621 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 2.391099e-02 | 1.621 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 2.391099e-02 | 1.621 |
| R-HSA-77042 | Formation of editosomes by ADAR proteins | 2.235229e-02 | 1.651 |
| R-HSA-6802949 | Signaling by RAS mutants | 2.391099e-02 | 1.621 |
| R-HSA-190828 | Gap junction trafficking | 2.170009e-02 | 1.664 |
| R-HSA-446728 | Cell junction organization | 2.085358e-02 | 1.681 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 2.398946e-02 | 1.620 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 2.506051e-02 | 1.601 |
| R-HSA-194138 | Signaling by VEGF | 2.215541e-02 | 1.655 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 2.063872e-02 | 1.685 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 2.170009e-02 | 1.664 |
| R-HSA-2028269 | Signaling by Hippo | 2.613687e-02 | 1.583 |
| R-HSA-157858 | Gap junction trafficking and regulation | 2.744754e-02 | 1.561 |
| R-HSA-156711 | Polo-like kinase mediated events | 2.835915e-02 | 1.547 |
| R-HSA-9603505 | NTRK3 as a dependence receptor | 3.334139e-02 | 1.477 |
| R-HSA-9636667 | Manipulation of host energy metabolism | 3.334139e-02 | 1.477 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 3.153665e-02 | 1.501 |
| R-HSA-9664407 | Parasite infection | 3.382589e-02 | 1.471 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 3.382589e-02 | 1.471 |
| R-HSA-9664417 | Leishmania phagocytosis | 3.382589e-02 | 1.471 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 3.795879e-02 | 1.421 |
| R-HSA-1640170 | Cell Cycle | 3.810032e-02 | 1.419 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 3.795879e-02 | 1.421 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 3.505203e-02 | 1.455 |
| R-HSA-9764561 | Regulation of CDH1 Function | 3.816022e-02 | 1.418 |
| R-HSA-1500931 | Cell-Cell communication | 3.828163e-02 | 1.417 |
| R-HSA-3560796 | Defective PAPSS2 causes SEMD-PA | 4.420764e-02 | 1.355 |
| R-HSA-9034013 | NTF3 activates NTRK3 signaling | 4.420764e-02 | 1.355 |
| R-HSA-68881 | Mitotic Metaphase/Anaphase Transition | 4.420764e-02 | 1.355 |
| R-HSA-5578997 | Defective AHCY causes HMAHCHD | 4.420764e-02 | 1.355 |
| R-HSA-75064 | mRNA Editing: A to I Conversion | 4.420764e-02 | 1.355 |
| R-HSA-194306 | Neurophilin interactions with VEGF and VEGFR | 4.420764e-02 | 1.355 |
| R-HSA-75102 | C6 deamination of adenosine | 4.420764e-02 | 1.355 |
| R-HSA-166208 | mTORC1-mediated signalling | 4.052707e-02 | 1.392 |
| R-HSA-9734767 | Developmental Cell Lineages | 4.302717e-02 | 1.366 |
| R-HSA-913531 | Interferon Signaling | 4.128694e-02 | 1.384 |
| R-HSA-8979227 | Triglyceride metabolism | 4.112579e-02 | 1.386 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 4.680087e-02 | 1.330 |
| R-HSA-9034793 | Activated NTRK3 signals through PLCG1 | 5.495240e-02 | 1.260 |
| R-HSA-5603037 | IRAK4 deficiency (TLR5) | 5.495240e-02 | 1.260 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 4.739454e-02 | 1.324 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 4.739454e-02 | 1.324 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 5.238638e-02 | 1.281 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 5.069514e-02 | 1.295 |
| R-HSA-5693606 | DNA Double Strand Break Response | 5.410465e-02 | 1.267 |
| R-HSA-111446 | Activation of BIM and translocation to mitochondria | 5.495240e-02 | 1.260 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 4.825808e-02 | 1.316 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 5.466457e-02 | 1.262 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 8.647122e-02 | 1.063 |
| R-HSA-9907570 | Loss-of-function mutations in DLD cause MSUD3/DLDD | 8.647122e-02 | 1.063 |
| R-HSA-9865113 | Loss-of-function mutations in DBT cause MSUD2 | 8.647122e-02 | 1.063 |
| R-HSA-9912481 | Branched-chain ketoacid dehydrogenase kinase deficiency | 9.674341e-02 | 1.014 |
| R-HSA-9865125 | Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD | 9.674341e-02 | 1.014 |
| R-HSA-9912529 | H139Hfs13* PPM1K causes a mild variant of MSUD | 9.674341e-02 | 1.014 |
| R-HSA-8931987 | RUNX1 regulates estrogen receptor mediated transcription | 1.069007e-01 | 0.971 |
| R-HSA-9603381 | Activated NTRK3 signals through PI3K | 1.069007e-01 | 0.971 |
| R-HSA-111367 | SLBP independent Processing of Histone Pre-mRNAs | 1.069007e-01 | 0.971 |
| R-HSA-9634635 | Estrogen-stimulated signaling through PRKCZ | 1.268758e-01 | 0.897 |
| R-HSA-9700645 | ALK mutants bind TKIs | 1.268758e-01 | 0.897 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 1.366961e-01 | 0.864 |
| R-HSA-9034864 | Activated NTRK3 signals through RAS | 1.464065e-01 | 0.834 |
| R-HSA-416550 | Sema4D mediated inhibition of cell attachment and migration | 1.560083e-01 | 0.807 |
| R-HSA-9865114 | Maple Syrup Urine Disease | 1.655027e-01 | 0.781 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 1.748909e-01 | 0.757 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 1.748909e-01 | 0.757 |
| R-HSA-9859138 | BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV | 1.841740e-01 | 0.735 |
| R-HSA-177504 | Retrograde neurotrophin signalling | 1.841740e-01 | 0.735 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 1.933532e-01 | 0.714 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 1.933532e-01 | 0.714 |
| R-HSA-8964315 | G beta:gamma signalling through BTK | 1.933532e-01 | 0.714 |
| R-HSA-168275 | Entry of Influenza Virion into Host Cell via Endocytosis | 2.024297e-01 | 0.694 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 2.377313e-01 | 0.624 |
| R-HSA-163210 | Formation of ATP by chemiosmotic coupling | 2.463111e-01 | 0.609 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 2.463111e-01 | 0.609 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 2.463111e-01 | 0.609 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.463111e-01 | 0.609 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 2.463111e-01 | 0.609 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.463111e-01 | 0.609 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 5.762151e-02 | 1.239 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 2.547949e-01 | 0.594 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 1.213602e-01 | 0.916 |
| R-HSA-774815 | Nucleosome assembly | 1.213602e-01 | 0.916 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 6.497059e-02 | 1.187 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 2.631837e-01 | 0.580 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 2.631837e-01 | 0.580 |
| R-HSA-380287 | Centrosome maturation | 6.879925e-02 | 1.162 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 2.796806e-01 | 0.553 |
| R-HSA-72649 | Translation initiation complex formation | 1.558604e-01 | 0.807 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 2.958101e-01 | 0.529 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 1.637645e-01 | 0.786 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 9.829354e-02 | 1.007 |
| R-HSA-194441 | Metabolism of non-coding RNA | 1.757496e-01 | 0.755 |
| R-HSA-191859 | snRNP Assembly | 1.757496e-01 | 0.755 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 3.269994e-01 | 0.485 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 3.345796e-01 | 0.476 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 2.463111e-01 | 0.609 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 9.668226e-02 | 1.015 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 1.028665e-01 | 0.988 |
| R-HSA-68962 | Activation of the pre-replicative complex | 3.345796e-01 | 0.476 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 2.664165e-01 | 0.574 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 7.911296e-02 | 1.102 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 2.714786e-01 | 0.566 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 1.757496e-01 | 0.755 |
| R-HSA-6798695 | Neutrophil degranulation | 9.437009e-02 | 1.025 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 2.958101e-01 | 0.529 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 3.050099e-01 | 0.516 |
| R-HSA-1606341 | IRF3 mediated activation of type 1 IFN | 7.608287e-02 | 1.119 |
| R-HSA-8849473 | PTK6 Expression | 1.069007e-01 | 0.971 |
| R-HSA-77588 | SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs | 1.169444e-01 | 0.932 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 2.114047e-01 | 0.675 |
| R-HSA-3928664 | Ephrin signaling | 2.290543e-01 | 0.640 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 3.345796e-01 | 0.476 |
| R-HSA-975110 | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | 2.114047e-01 | 0.675 |
| R-HSA-3000157 | Laminin interactions | 2.958101e-01 | 0.529 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 1.109194e-01 | 0.955 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 1.067216e-01 | 0.972 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 2.631837e-01 | 0.580 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 1.878686e-01 | 0.726 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 1.370779e-01 | 0.863 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 3.269994e-01 | 0.485 |
| R-HSA-165159 | MTOR signalling | 1.103346e-01 | 0.957 |
| R-HSA-176417 | Phosphorylation of Emi1 | 8.647122e-02 | 1.063 |
| R-HSA-8939256 | RUNX1 regulates transcription of genes involved in WNT signaling | 9.674341e-02 | 1.014 |
| R-HSA-176974 | Unwinding of DNA | 1.268758e-01 | 0.897 |
| R-HSA-9762292 | Regulation of CDH11 function | 1.366961e-01 | 0.864 |
| R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 1.366961e-01 | 0.864 |
| R-HSA-6803544 | Ion influx/efflux at host-pathogen interface | 1.366961e-01 | 0.864 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 1.560083e-01 | 0.807 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 1.655027e-01 | 0.781 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 1.748909e-01 | 0.757 |
| R-HSA-174490 | Membrane binding and targetting of GAG proteins | 1.748909e-01 | 0.757 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 1.748909e-01 | 0.757 |
| R-HSA-176412 | Phosphorylation of the APC/C | 2.024297e-01 | 0.694 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 8.578146e-02 | 1.067 |
| R-HSA-8949613 | Cristae formation | 3.115804e-01 | 0.506 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 3.269994e-01 | 0.485 |
| R-HSA-6805567 | Keratinization | 2.534064e-01 | 0.596 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 7.076081e-02 | 1.150 |
| R-HSA-5617833 | Cilium Assembly | 2.125394e-01 | 0.673 |
| R-HSA-9865118 | Diseases of branched-chain amino acid catabolism | 3.037396e-01 | 0.517 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 7.584312e-02 | 1.120 |
| R-HSA-912631 | Regulation of signaling by CBL | 2.377313e-01 | 0.624 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 2.463111e-01 | 0.609 |
| R-HSA-9711097 | Cellular response to starvation | 3.203800e-01 | 0.494 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 2.290543e-01 | 0.640 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 8.647122e-02 | 1.063 |
| R-HSA-1855191 | Synthesis of IPs in the nucleus | 1.841740e-01 | 0.735 |
| R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 1.841740e-01 | 0.735 |
| R-HSA-174362 | Transport and metabolism of PAPS | 1.933532e-01 | 0.714 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 2.024297e-01 | 0.694 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 2.877907e-01 | 0.541 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 2.289590e-01 | 0.640 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 2.290543e-01 | 0.640 |
| R-HSA-2424491 | DAP12 signaling | 3.345796e-01 | 0.476 |
| R-HSA-195399 | VEGF binds to VEGFR leading to receptor dimerization | 8.647122e-02 | 1.063 |
| R-HSA-75072 | mRNA Editing | 1.268758e-01 | 0.897 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 1.268758e-01 | 0.897 |
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 1.366961e-01 | 0.864 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 9.608601e-02 | 1.017 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 1.250939e-01 | 0.903 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 1.558604e-01 | 0.807 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 2.958101e-01 | 0.529 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 1.717385e-01 | 0.765 |
| R-HSA-6809371 | Formation of the cornified envelope | 7.253338e-02 | 1.139 |
| R-HSA-9615710 | Late endosomal microautophagy | 3.269994e-01 | 0.485 |
| R-HSA-68886 | M Phase | 8.853467e-02 | 1.053 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 1.326422e-01 | 0.877 |
| R-HSA-2132295 | MHC class II antigen presentation | 2.029041e-01 | 0.693 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 2.958101e-01 | 0.529 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 2.958101e-01 | 0.529 |
| R-HSA-69275 | G2/M Transition | 8.446671e-02 | 1.073 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 1.054747e-01 | 0.977 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 8.714792e-02 | 1.060 |
| R-HSA-2408550 | Metabolism of ingested H2SeO4 and H2SeO3 into H2Se | 2.202792e-01 | 0.657 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 9.959610e-02 | 1.002 |
| R-HSA-5260271 | Diseases of Immune System | 9.959610e-02 | 1.002 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 3.345796e-01 | 0.476 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 1.560083e-01 | 0.807 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 2.114047e-01 | 0.675 |
| R-HSA-416482 | G alpha (12/13) signalling events | 7.472961e-02 | 1.127 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 2.377313e-01 | 0.624 |
| R-HSA-373760 | L1CAM interactions | 6.109199e-02 | 1.214 |
| R-HSA-9706374 | FLT3 signaling through SRC family kinases | 6.557703e-02 | 1.183 |
| R-HSA-194313 | VEGF ligand-receptor interactions | 8.647122e-02 | 1.063 |
| R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 | 9.674341e-02 | 1.014 |
| R-HSA-1237044 | Erythrocytes take up carbon dioxide and release oxygen | 2.377313e-01 | 0.624 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 2.372618e-01 | 0.625 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 1.677432e-01 | 0.775 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 1.717385e-01 | 0.765 |
| R-HSA-9768777 | Regulation of NPAS4 gene transcription | 1.268758e-01 | 0.897 |
| R-HSA-416700 | Other semaphorin interactions | 1.933532e-01 | 0.714 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 2.114047e-01 | 0.675 |
| R-HSA-1480926 | O2/CO2 exchange in erythrocytes | 2.377313e-01 | 0.624 |
| R-HSA-9610379 | HCMV Late Events | 3.173044e-01 | 0.499 |
| R-HSA-69481 | G2/M Checkpoints | 2.174575e-01 | 0.663 |
| R-HSA-69278 | Cell Cycle, Mitotic | 7.087866e-02 | 1.149 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 7.608287e-02 | 1.119 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 8.647122e-02 | 1.063 |
| R-HSA-8964011 | HDL clearance | 9.674341e-02 | 1.014 |
| R-HSA-164944 | Nef and signal transduction | 9.674341e-02 | 1.014 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 1.169444e-01 | 0.932 |
| R-HSA-6799990 | Metal sequestration by antimicrobial proteins | 1.366961e-01 | 0.864 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 1.841740e-01 | 0.735 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 1.933532e-01 | 0.714 |
| R-HSA-8874081 | MET activates PTK2 signaling | 3.037396e-01 | 0.517 |
| R-HSA-3214847 | HATs acetylate histones | 1.294435e-01 | 0.888 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 3.019393e-01 | 0.520 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 1.914358e-01 | 0.718 |
| R-HSA-168898 | Toll-like Receptor Cascades | 2.148908e-01 | 0.668 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 1.914358e-01 | 0.718 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 2.000216e-01 | 0.699 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 3.115804e-01 | 0.506 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 6.932367e-02 | 1.159 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 6.879925e-02 | 1.162 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 2.000216e-01 | 0.699 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 2.202792e-01 | 0.657 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 2.124215e-01 | 0.673 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 3.269994e-01 | 0.485 |
| R-HSA-418990 | Adherens junctions interactions | 1.341464e-01 | 0.872 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 9.831240e-02 | 1.007 |
| R-HSA-70171 | Glycolysis | 1.319711e-01 | 0.880 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 6.813569e-02 | 1.167 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 6.813569e-02 | 1.167 |
| R-HSA-421270 | Cell-cell junction organization | 1.940422e-01 | 0.712 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 1.202665e-01 | 0.920 |
| R-HSA-1247673 | Erythrocytes take up oxygen and release carbon dioxide | 1.655027e-01 | 0.781 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 1.841740e-01 | 0.735 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 2.024297e-01 | 0.694 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 9.608601e-02 | 1.017 |
| R-HSA-1632852 | Macroautophagy | 2.652817e-01 | 0.576 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 1.366961e-01 | 0.864 |
| R-HSA-9659379 | Sensory processing of sound | 2.580784e-01 | 0.588 |
| R-HSA-168255 | Influenza Infection | 1.871941e-01 | 0.728 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 6.879925e-02 | 1.162 |
| R-HSA-8964038 | LDL clearance | 2.714786e-01 | 0.566 |
| R-HSA-70326 | Glucose metabolism | 1.857659e-01 | 0.731 |
| R-HSA-9612973 | Autophagy | 1.358986e-01 | 0.867 |
| R-HSA-193648 | NRAGE signals death through JNK | 1.637645e-01 | 0.786 |
| R-HSA-9638630 | Attachment of bacteria to epithelial cells | 3.037396e-01 | 0.517 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 2.124215e-01 | 0.673 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 1.527901e-01 | 0.816 |
| R-HSA-9700206 | Signaling by ALK in cancer | 1.527901e-01 | 0.816 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 1.480335e-01 | 0.830 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 2.331081e-01 | 0.632 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 2.721808e-01 | 0.565 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 2.713587e-01 | 0.566 |
| R-HSA-422475 | Axon guidance | 1.929857e-01 | 0.714 |
| R-HSA-175474 | Assembly Of The HIV Virion | 2.631837e-01 | 0.580 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 1.637645e-01 | 0.786 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 2.873019e-01 | 0.542 |
| R-HSA-9675108 | Nervous system development | 1.472466e-01 | 0.832 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 1.513280e-01 | 0.820 |
| R-HSA-70263 | Gluconeogenesis | 1.326422e-01 | 0.877 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 1.268758e-01 | 0.897 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 1.501323e-01 | 0.824 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 1.838155e-01 | 0.736 |
| R-HSA-438064 | Post NMDA receptor activation events | 2.955727e-01 | 0.529 |
| R-HSA-9842663 | Signaling by LTK | 1.655027e-01 | 0.781 |
| R-HSA-9629569 | Protein hydroxylation | 2.463111e-01 | 0.609 |
| R-HSA-9824443 | Parasitic Infection Pathways | 2.551254e-01 | 0.593 |
| R-HSA-9658195 | Leishmania infection | 2.551254e-01 | 0.593 |
| R-HSA-3247509 | Chromatin modifying enzymes | 3.236071e-01 | 0.490 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 2.830884e-01 | 0.548 |
| R-HSA-877300 | Interferon gamma signaling | 1.419646e-01 | 0.848 |
| R-HSA-5673000 | RAF activation | 7.911296e-02 | 1.102 |
| R-HSA-180024 | DARPP-32 events | 3.269994e-01 | 0.485 |
| R-HSA-909733 | Interferon alpha/beta signaling | 5.973458e-02 | 1.224 |
| R-HSA-74160 | Gene expression (Transcription) | 3.175062e-01 | 0.498 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 5.973458e-02 | 1.224 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 8.917739e-02 | 1.050 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 3.204367e-01 | 0.494 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 1.176550e-01 | 0.929 |
| R-HSA-8983711 | OAS antiviral response | 1.655027e-01 | 0.781 |
| R-HSA-9824446 | Viral Infection Pathways | 2.274472e-01 | 0.643 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 1.637645e-01 | 0.786 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 2.331081e-01 | 0.632 |
| R-HSA-9006936 | Signaling by TGFB family members | 1.440104e-01 | 0.842 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 2.958031e-01 | 0.529 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 1.063531e-01 | 0.973 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 6.943927e-02 | 1.158 |
| R-HSA-114452 | Activation of BH3-only proteins | 3.345796e-01 | 0.476 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 2.041977e-01 | 0.690 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 2.796806e-01 | 0.553 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 2.877907e-01 | 0.541 |
| R-HSA-8863678 | Neurodegenerative Diseases | 2.877907e-01 | 0.541 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 3.115804e-01 | 0.506 |
| R-HSA-75153 | Apoptotic execution phase | 1.250939e-01 | 0.903 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 6.809175e-02 | 1.167 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 2.000995e-01 | 0.699 |
| R-HSA-109581 | Apoptosis | 3.326844e-01 | 0.478 |
| R-HSA-9020591 | Interleukin-12 signaling | 2.455807e-01 | 0.610 |
| R-HSA-9909396 | Circadian clock | 2.351965e-01 | 0.629 |
| R-HSA-447115 | Interleukin-12 family signaling | 2.955727e-01 | 0.529 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 3.368991e-01 | 0.473 |
| R-HSA-2408522 | Selenoamino acid metabolism | 3.388349e-01 | 0.470 |
| R-HSA-8953897 | Cellular responses to stimuli | 3.398976e-01 | 0.469 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 3.401401e-01 | 0.468 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 3.409969e-01 | 0.467 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 3.420749e-01 | 0.466 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 3.420749e-01 | 0.466 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 3.420749e-01 | 0.466 |
| R-HSA-162588 | Budding and maturation of HIV virion | 3.420749e-01 | 0.466 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 3.420749e-01 | 0.466 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 3.420749e-01 | 0.466 |
| R-HSA-69190 | DNA strand elongation | 3.494862e-01 | 0.457 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 3.532423e-01 | 0.452 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 3.562300e-01 | 0.448 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 3.568145e-01 | 0.448 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 3.568145e-01 | 0.448 |
| R-HSA-5083635 | Defective B3GALTL causes PpS | 3.568145e-01 | 0.448 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 3.568145e-01 | 0.448 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 3.568145e-01 | 0.448 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 3.568145e-01 | 0.448 |
| R-HSA-397795 | G-protein beta:gamma signalling | 3.568145e-01 | 0.448 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 3.568145e-01 | 0.448 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 3.568145e-01 | 0.448 |
| R-HSA-168249 | Innate Immune System | 3.575503e-01 | 0.447 |
| R-HSA-72306 | tRNA processing | 3.603275e-01 | 0.443 |
| R-HSA-9020702 | Interleukin-1 signaling | 3.613624e-01 | 0.442 |
| R-HSA-4839726 | Chromatin organization | 3.618680e-01 | 0.441 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 3.640607e-01 | 0.439 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 3.640607e-01 | 0.439 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 3.640607e-01 | 0.439 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 3.640607e-01 | 0.439 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 3.640607e-01 | 0.439 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 3.640607e-01 | 0.439 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 3.640607e-01 | 0.439 |
| R-HSA-9609646 | HCMV Infection | 3.644210e-01 | 0.438 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 3.654084e-01 | 0.437 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 3.712257e-01 | 0.430 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 3.712257e-01 | 0.430 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 3.712257e-01 | 0.430 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 3.712257e-01 | 0.430 |
| R-HSA-180746 | Nuclear import of Rev protein | 3.712257e-01 | 0.430 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 3.734711e-01 | 0.428 |
| R-HSA-111885 | Opioid Signalling | 3.734711e-01 | 0.428 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 3.756219e-01 | 0.425 |
| R-HSA-9833110 | RSV-host interactions | 3.774871e-01 | 0.423 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 3.783104e-01 | 0.422 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 3.783104e-01 | 0.422 |
| R-HSA-2408508 | Metabolism of ingested SeMet, Sec, MeSec into H2Se | 3.783104e-01 | 0.422 |
| R-HSA-5663205 | Infectious disease | 3.799212e-01 | 0.420 |
| R-HSA-74158 | RNA Polymerase III Transcription | 3.853157e-01 | 0.414 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 3.853157e-01 | 0.414 |
| R-HSA-111933 | Calmodulin induced events | 3.853157e-01 | 0.414 |
| R-HSA-111997 | CaM pathway | 3.853157e-01 | 0.414 |
| R-HSA-114604 | GPVI-mediated activation cascade | 3.853157e-01 | 0.414 |
| R-HSA-5173214 | O-glycosylation of TSR domain-containing proteins | 3.922425e-01 | 0.406 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 3.922425e-01 | 0.406 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 3.922425e-01 | 0.406 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 3.922425e-01 | 0.406 |
| R-HSA-196757 | Metabolism of folate and pterines | 3.922425e-01 | 0.406 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 3.934427e-01 | 0.405 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 3.934427e-01 | 0.405 |
| R-HSA-1643685 | Disease | 3.970768e-01 | 0.401 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 3.990917e-01 | 0.399 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 3.990917e-01 | 0.399 |
| R-HSA-9931953 | Biofilm formation | 3.990917e-01 | 0.399 |
| R-HSA-8875878 | MET promotes cell motility | 3.990917e-01 | 0.399 |
| R-HSA-5683057 | MAPK family signaling cascades | 4.003622e-01 | 0.398 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 4.048176e-01 | 0.393 |
| R-HSA-6803157 | Antimicrobial peptides | 4.052883e-01 | 0.392 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 4.058641e-01 | 0.392 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 4.092125e-01 | 0.388 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 4.092125e-01 | 0.388 |
| R-HSA-1483249 | Inositol phosphate metabolism | 4.092125e-01 | 0.388 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 4.125605e-01 | 0.385 |
| R-HSA-9646399 | Aggrephagy | 4.125605e-01 | 0.385 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 4.125605e-01 | 0.385 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 4.125605e-01 | 0.385 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 4.125605e-01 | 0.385 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 4.170231e-01 | 0.380 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 4.191820e-01 | 0.378 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 4.191820e-01 | 0.378 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 4.191820e-01 | 0.378 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 4.191820e-01 | 0.378 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 4.191820e-01 | 0.378 |
| R-HSA-9607240 | FLT3 Signaling | 4.191820e-01 | 0.378 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 4.247819e-01 | 0.372 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 4.257292e-01 | 0.371 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 4.257292e-01 | 0.371 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 4.322030e-01 | 0.364 |
| R-HSA-111996 | Ca-dependent events | 4.322030e-01 | 0.364 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 4.324872e-01 | 0.364 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 4.324872e-01 | 0.364 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 4.329242e-01 | 0.364 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 4.379043e-01 | 0.359 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 4.386042e-01 | 0.358 |
| R-HSA-5693538 | Homology Directed Repair | 4.401377e-01 | 0.356 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 4.439419e-01 | 0.353 |
| R-HSA-9907900 | Proteasome assembly | 4.449336e-01 | 0.352 |
| R-HSA-2172127 | DAP12 interactions | 4.449336e-01 | 0.352 |
| R-HSA-156581 | Methylation | 4.449336e-01 | 0.352 |
| R-HSA-373752 | Netrin-1 signaling | 4.449336e-01 | 0.352 |
| R-HSA-68875 | Mitotic Prophase | 4.477318e-01 | 0.349 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 4.511921e-01 | 0.346 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 4.511921e-01 | 0.346 |
| R-HSA-3560782 | Diseases associated with glycosaminoglycan metabolism | 4.511921e-01 | 0.346 |
| R-HSA-1489509 | DAG and IP3 signaling | 4.511921e-01 | 0.346 |
| R-HSA-73886 | Chromosome Maintenance | 4.515073e-01 | 0.345 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 4.573804e-01 | 0.340 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 4.573804e-01 | 0.340 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 4.573804e-01 | 0.340 |
| R-HSA-9675135 | Diseases of DNA repair | 4.573804e-01 | 0.340 |
| R-HSA-162909 | Host Interactions of HIV factors | 4.627459e-01 | 0.335 |
| R-HSA-72172 | mRNA Splicing | 4.652414e-01 | 0.332 |
| R-HSA-1266738 | Developmental Biology | 4.654549e-01 | 0.332 |
| R-HSA-5357801 | Programmed Cell Death | 4.681406e-01 | 0.330 |
| R-HSA-5620924 | Intraflagellar transport | 4.695495e-01 | 0.328 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 4.695495e-01 | 0.328 |
| R-HSA-9766229 | Degradation of CDH1 | 4.755319e-01 | 0.323 |
| R-HSA-73857 | RNA Polymerase II Transcription | 4.762005e-01 | 0.322 |
| R-HSA-9679506 | SARS-CoV Infections | 4.765233e-01 | 0.322 |
| R-HSA-199991 | Membrane Trafficking | 4.860410e-01 | 0.313 |
| R-HSA-70895 | Branched-chain amino acid catabolism | 4.872961e-01 | 0.312 |
| R-HSA-912446 | Meiotic recombination | 4.872961e-01 | 0.312 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 4.910778e-01 | 0.309 |
| R-HSA-68949 | Orc1 removal from chromatin | 4.930795e-01 | 0.307 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 4.930795e-01 | 0.307 |
| R-HSA-6794361 | Neurexins and neuroligins | 4.930795e-01 | 0.307 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 4.930795e-01 | 0.307 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 4.987979e-01 | 0.302 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 4.987979e-01 | 0.302 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 4.987979e-01 | 0.302 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 4.987979e-01 | 0.302 |
| R-HSA-8956320 | Nucleotide biosynthesis | 4.987979e-01 | 0.302 |
| R-HSA-8953854 | Metabolism of RNA | 5.031432e-01 | 0.298 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 5.100430e-01 | 0.292 |
| R-HSA-212436 | Generic Transcription Pathway | 5.142950e-01 | 0.289 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 5.155712e-01 | 0.288 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 5.155712e-01 | 0.288 |
| R-HSA-162906 | HIV Infection | 5.300168e-01 | 0.276 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 5.370702e-01 | 0.270 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 5.370702e-01 | 0.270 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 5.370702e-01 | 0.270 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 5.370702e-01 | 0.270 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 5.408420e-01 | 0.267 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 5.422949e-01 | 0.266 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 5.422949e-01 | 0.266 |
| R-HSA-112043 | PLC beta mediated events | 5.422949e-01 | 0.266 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 5.439719e-01 | 0.264 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 5.474611e-01 | 0.262 |
| R-HSA-6784531 | tRNA processing in the nucleus | 5.474611e-01 | 0.262 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 5.474611e-01 | 0.262 |
| R-HSA-186797 | Signaling by PDGF | 5.474611e-01 | 0.262 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 5.474611e-01 | 0.262 |
| R-HSA-6799198 | Complex I biogenesis | 5.525692e-01 | 0.258 |
| R-HSA-373755 | Semaphorin interactions | 5.525692e-01 | 0.258 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 5.525692e-01 | 0.258 |
| R-HSA-8848021 | Signaling by PTK6 | 5.525692e-01 | 0.258 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 5.525692e-01 | 0.258 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 5.574716e-01 | 0.254 |
| R-HSA-936837 | Ion transport by P-type ATPases | 5.576200e-01 | 0.254 |
| R-HSA-166520 | Signaling by NTRKs | 5.607461e-01 | 0.251 |
| R-HSA-9679191 | Potential therapeutics for SARS | 5.672435e-01 | 0.246 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 5.724347e-01 | 0.242 |
| R-HSA-112040 | G-protein mediated events | 5.724347e-01 | 0.242 |
| R-HSA-446652 | Interleukin-1 family signaling | 5.736718e-01 | 0.241 |
| R-HSA-73887 | Death Receptor Signaling | 5.800308e-01 | 0.237 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 5.831843e-01 | 0.234 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 5.867559e-01 | 0.232 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 5.867559e-01 | 0.232 |
| R-HSA-162587 | HIV Life Cycle | 5.894393e-01 | 0.230 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 5.914228e-01 | 0.228 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 5.914228e-01 | 0.228 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 5.914228e-01 | 0.228 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 5.914228e-01 | 0.228 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 5.914228e-01 | 0.228 |
| R-HSA-3000178 | ECM proteoglycans | 5.914228e-01 | 0.228 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 5.960373e-01 | 0.225 |
| R-HSA-74259 | Purine catabolism | 5.960373e-01 | 0.225 |
| R-HSA-5633007 | Regulation of TP53 Activity | 5.986914e-01 | 0.223 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 6.006000e-01 | 0.221 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 6.006000e-01 | 0.221 |
| R-HSA-5688426 | Deubiquitination | 6.026520e-01 | 0.220 |
| R-HSA-1236394 | Signaling by ERBB4 | 6.051114e-01 | 0.218 |
| R-HSA-8852135 | Protein ubiquitination | 6.095721e-01 | 0.215 |
| R-HSA-5689603 | UCH proteinases | 6.139827e-01 | 0.212 |
| R-HSA-4086400 | PCP/CE pathway | 6.226558e-01 | 0.206 |
| R-HSA-73894 | DNA Repair | 6.247064e-01 | 0.204 |
| R-HSA-5579029 | Metabolic disorders of biological oxidation enzymes | 6.269194e-01 | 0.203 |
| R-HSA-9833482 | PKR-mediated signaling | 6.311351e-01 | 0.200 |
| R-HSA-6806834 | Signaling by MET | 6.311351e-01 | 0.200 |
| R-HSA-2262752 | Cellular responses to stress | 6.316516e-01 | 0.200 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 6.394249e-01 | 0.194 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 6.475294e-01 | 0.189 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 6.475696e-01 | 0.189 |
| R-HSA-168256 | Immune System | 6.504356e-01 | 0.187 |
| R-HSA-1500620 | Meiosis | 6.515134e-01 | 0.186 |
| R-HSA-2559583 | Cellular Senescence | 6.590920e-01 | 0.181 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 6.593476e-01 | 0.181 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 6.593476e-01 | 0.181 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 6.593476e-01 | 0.181 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 6.593476e-01 | 0.181 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 6.631988e-01 | 0.178 |
| R-HSA-156902 | Peptide chain elongation | 6.670066e-01 | 0.176 |
| R-HSA-9663891 | Selective autophagy | 6.670066e-01 | 0.176 |
| R-HSA-9645723 | Diseases of programmed cell death | 6.670066e-01 | 0.176 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 6.671037e-01 | 0.176 |
| R-HSA-3781865 | Diseases of glycosylation | 6.697405e-01 | 0.174 |
| R-HSA-1236974 | ER-Phagosome pathway | 6.707717e-01 | 0.173 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 6.744944e-01 | 0.171 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 6.781753e-01 | 0.169 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 6.818147e-01 | 0.166 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 6.854132e-01 | 0.164 |
| R-HSA-391251 | Protein folding | 6.854132e-01 | 0.164 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 6.889713e-01 | 0.162 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 6.889713e-01 | 0.162 |
| R-HSA-2029481 | FCGR activation | 6.889713e-01 | 0.162 |
| R-HSA-9837999 | Mitochondrial protein degradation | 6.924893e-01 | 0.160 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 6.959677e-01 | 0.157 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 6.959677e-01 | 0.157 |
| R-HSA-195721 | Signaling by WNT | 6.990303e-01 | 0.156 |
| R-HSA-72764 | Eukaryotic Translation Termination | 6.994070e-01 | 0.155 |
| R-HSA-9609690 | HCMV Early Events | 7.000842e-01 | 0.155 |
| R-HSA-5389840 | Mitochondrial translation elongation | 7.028076e-01 | 0.153 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 7.028076e-01 | 0.153 |
| R-HSA-5368286 | Mitochondrial translation initiation | 7.094945e-01 | 0.149 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 7.094945e-01 | 0.149 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 7.094945e-01 | 0.149 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 7.094945e-01 | 0.149 |
| R-HSA-9614085 | FOXO-mediated transcription | 7.127816e-01 | 0.147 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 7.143743e-01 | 0.146 |
| R-HSA-2408557 | Selenocysteine synthesis | 7.192452e-01 | 0.143 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 7.224226e-01 | 0.141 |
| R-HSA-1483255 | PI Metabolism | 7.224226e-01 | 0.141 |
| R-HSA-5653656 | Vesicle-mediated transport | 7.243022e-01 | 0.140 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 7.255642e-01 | 0.139 |
| R-HSA-192823 | Viral mRNA Translation | 7.255642e-01 | 0.139 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 7.286705e-01 | 0.137 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 7.347784e-01 | 0.134 |
| R-HSA-5696398 | Nucleotide Excision Repair | 7.347784e-01 | 0.134 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 7.390969e-01 | 0.131 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 7.407496e-01 | 0.130 |
| R-HSA-69239 | Synthesis of DNA | 7.407496e-01 | 0.130 |
| R-HSA-211000 | Gene Silencing by RNA | 7.407496e-01 | 0.130 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 7.436849e-01 | 0.129 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 7.436849e-01 | 0.129 |
| R-HSA-5419276 | Mitochondrial translation termination | 7.465871e-01 | 0.127 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 7.465871e-01 | 0.127 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 7.465871e-01 | 0.127 |
| R-HSA-5668914 | Diseases of metabolism | 7.477399e-01 | 0.126 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 7.494567e-01 | 0.125 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 7.494567e-01 | 0.125 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 7.578728e-01 | 0.120 |
| R-HSA-1474244 | Extracellular matrix organization | 7.602572e-01 | 0.119 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 7.660078e-01 | 0.116 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 7.686585e-01 | 0.114 |
| R-HSA-1592230 | Mitochondrial biogenesis | 7.738708e-01 | 0.111 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 7.756254e-01 | 0.110 |
| R-HSA-3371556 | Cellular response to heat stress | 7.839476e-01 | 0.106 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 7.839476e-01 | 0.106 |
| R-HSA-15869 | Metabolism of nucleotides | 7.867755e-01 | 0.104 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 7.885704e-01 | 0.103 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 7.888173e-01 | 0.103 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 7.959178e-01 | 0.099 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 7.959178e-01 | 0.099 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 7.959178e-01 | 0.099 |
| R-HSA-69206 | G1/S Transition | 7.959178e-01 | 0.099 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 7.982315e-01 | 0.098 |
| R-HSA-388396 | GPCR downstream signalling | 7.987699e-01 | 0.098 |
| R-HSA-114608 | Platelet degranulation | 8.005190e-01 | 0.097 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 8.018219e-01 | 0.096 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 8.027808e-01 | 0.095 |
| R-HSA-8956319 | Nucleotide catabolism | 8.050171e-01 | 0.094 |
| R-HSA-112316 | Neuronal System | 8.056651e-01 | 0.094 |
| R-HSA-1474165 | Reproduction | 8.094143e-01 | 0.092 |
| R-HSA-9843745 | Adipogenesis | 8.115758e-01 | 0.091 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 8.137129e-01 | 0.090 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 8.158259e-01 | 0.088 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 8.240421e-01 | 0.084 |
| R-HSA-5173105 | O-linked glycosylation | 8.260385e-01 | 0.083 |
| R-HSA-5368287 | Mitochondrial translation | 8.280125e-01 | 0.082 |
| R-HSA-9948299 | Ribosome-associated quality control | 8.280125e-01 | 0.082 |
| R-HSA-6807070 | PTEN Regulation | 8.299641e-01 | 0.081 |
| R-HSA-416476 | G alpha (q) signalling events | 8.326151e-01 | 0.080 |
| R-HSA-9711123 | Cellular response to chemical stress | 8.383894e-01 | 0.077 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 8.448047e-01 | 0.073 |
| R-HSA-69242 | S Phase | 8.483090e-01 | 0.071 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 8.550831e-01 | 0.068 |
| R-HSA-69306 | DNA Replication | 8.567291e-01 | 0.067 |
| R-HSA-449147 | Signaling by Interleukins | 8.581168e-01 | 0.066 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 8.583565e-01 | 0.066 |
| R-HSA-1989781 | PPARA activates gene expression | 8.599656e-01 | 0.066 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 8.631293e-01 | 0.064 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 8.646843e-01 | 0.063 |
| R-HSA-372790 | Signaling by GPCR | 8.720216e-01 | 0.059 |
| R-HSA-5619102 | SLC transporter disorders | 8.779126e-01 | 0.057 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 8.833711e-01 | 0.054 |
| R-HSA-418555 | G alpha (s) signalling events | 8.846974e-01 | 0.053 |
| R-HSA-72766 | Translation | 8.858759e-01 | 0.053 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 8.873051e-01 | 0.052 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 8.873051e-01 | 0.052 |
| R-HSA-5689880 | Ub-specific processing proteases | 8.873051e-01 | 0.052 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 8.898541e-01 | 0.051 |
| R-HSA-611105 | Respiratory electron transport | 8.935706e-01 | 0.049 |
| R-HSA-112315 | Transmission across Chemical Synapses | 9.014249e-01 | 0.045 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 9.050810e-01 | 0.043 |
| R-HSA-983712 | Ion channel transport | 9.061616e-01 | 0.043 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 9.103630e-01 | 0.041 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.165039e-01 | 0.038 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 9.172703e-01 | 0.038 |
| R-HSA-428157 | Sphingolipid metabolism | 9.182128e-01 | 0.037 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 9.200660e-01 | 0.036 |
| R-HSA-376176 | Signaling by ROBO receptors | 9.200660e-01 | 0.036 |
| R-HSA-9640148 | Infection with Enterobacteria | 9.200660e-01 | 0.036 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.326431e-01 | 0.030 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.329545e-01 | 0.030 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 9.392998e-01 | 0.027 |
| R-HSA-72312 | rRNA processing | 9.433400e-01 | 0.025 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 9.442442e-01 | 0.025 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 9.477166e-01 | 0.023 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.478378e-01 | 0.023 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 9.523082e-01 | 0.021 |
| R-HSA-418594 | G alpha (i) signalling events | 9.556727e-01 | 0.020 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.616439e-01 | 0.017 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 9.681172e-01 | 0.014 |
| R-HSA-1483257 | Phospholipid metabolism | 9.725527e-01 | 0.012 |
| R-HSA-109582 | Hemostasis | 9.823031e-01 | 0.008 |
| R-HSA-597592 | Post-translational protein modification | 9.858429e-01 | 0.006 |
| R-HSA-1280218 | Adaptive Immune System | 9.940109e-01 | 0.003 |
| R-HSA-382551 | Transport of small molecules | 9.968723e-01 | 0.001 |
| R-HSA-211859 | Biological oxidations | 9.980785e-01 | 0.001 |
| R-HSA-500792 | GPCR ligand binding | 9.991136e-01 | 0.000 |
| R-HSA-392499 | Metabolism of proteins | 9.991280e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.995833e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999612e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999939e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
PIM3 |
0.889 | 0.389 | -3 | 0.895 |
COT |
0.888 | 0.157 | 2 | 0.895 |
CDKL5 |
0.888 | 0.436 | -3 | 0.912 |
CDKL1 |
0.888 | 0.453 | -3 | 0.909 |
NDR1 |
0.887 | 0.370 | -3 | 0.881 |
RSK2 |
0.887 | 0.416 | -3 | 0.894 |
P90RSK |
0.886 | 0.417 | -3 | 0.905 |
NDR2 |
0.885 | 0.290 | -3 | 0.872 |
RSK3 |
0.884 | 0.402 | -3 | 0.886 |
PIM1 |
0.883 | 0.442 | -3 | 0.875 |
PKN3 |
0.882 | 0.315 | -3 | 0.892 |
PKCD |
0.882 | 0.329 | 2 | 0.834 |
SRPK1 |
0.882 | 0.375 | -3 | 0.888 |
PRKD2 |
0.881 | 0.348 | -3 | 0.854 |
WNK1 |
0.881 | 0.271 | -2 | 0.922 |
CAMK1B |
0.880 | 0.324 | -3 | 0.896 |
P70S6KB |
0.880 | 0.383 | -3 | 0.884 |
SRPK2 |
0.879 | 0.399 | -3 | 0.853 |
SKMLCK |
0.878 | 0.295 | -2 | 0.902 |
CLK3 |
0.878 | 0.277 | 1 | 0.788 |
PKACG |
0.878 | 0.303 | -2 | 0.810 |
GCN2 |
0.877 | -0.048 | 2 | 0.835 |
PRKD1 |
0.877 | 0.243 | -3 | 0.875 |
MAPKAPK3 |
0.877 | 0.318 | -3 | 0.851 |
CDC7 |
0.876 | 0.052 | 1 | 0.844 |
RIPK3 |
0.876 | 0.134 | 3 | 0.803 |
ICK |
0.876 | 0.361 | -3 | 0.914 |
RAF1 |
0.876 | 0.085 | 1 | 0.885 |
HIPK4 |
0.876 | 0.280 | 1 | 0.777 |
NUAK2 |
0.876 | 0.295 | -3 | 0.881 |
ULK2 |
0.876 | -0.015 | 2 | 0.819 |
RSK4 |
0.876 | 0.413 | -3 | 0.884 |
CAMLCK |
0.876 | 0.309 | -2 | 0.895 |
PKN2 |
0.874 | 0.268 | -3 | 0.854 |
TBK1 |
0.874 | 0.002 | 1 | 0.790 |
TGFBR2 |
0.874 | 0.090 | -2 | 0.819 |
MSK2 |
0.874 | 0.348 | -3 | 0.869 |
AURC |
0.874 | 0.248 | -2 | 0.701 |
MST4 |
0.874 | 0.191 | 2 | 0.856 |
PRPK |
0.874 | -0.040 | -1 | 0.884 |
LATS2 |
0.873 | 0.215 | -5 | 0.731 |
NIK |
0.873 | 0.296 | -3 | 0.864 |
CAMK2D |
0.872 | 0.219 | -3 | 0.864 |
IKKB |
0.872 | -0.037 | -2 | 0.806 |
DSTYK |
0.872 | -0.006 | 2 | 0.916 |
PRKD3 |
0.872 | 0.353 | -3 | 0.852 |
ATR |
0.872 | 0.091 | 1 | 0.873 |
PIM2 |
0.872 | 0.447 | -3 | 0.873 |
DAPK2 |
0.871 | 0.309 | -3 | 0.891 |
AMPKA1 |
0.871 | 0.245 | -3 | 0.867 |
MOS |
0.871 | 0.054 | 1 | 0.870 |
MARK4 |
0.871 | 0.134 | 4 | 0.834 |
NLK |
0.871 | 0.074 | 1 | 0.798 |
NIM1 |
0.871 | 0.192 | 3 | 0.818 |
MNK2 |
0.870 | 0.215 | -2 | 0.842 |
SGK3 |
0.870 | 0.386 | -3 | 0.854 |
PKACB |
0.870 | 0.350 | -2 | 0.725 |
PDHK4 |
0.870 | -0.177 | 1 | 0.875 |
MTOR |
0.869 | -0.050 | 1 | 0.786 |
MAPKAPK2 |
0.869 | 0.311 | -3 | 0.845 |
MELK |
0.869 | 0.304 | -3 | 0.861 |
NEK6 |
0.869 | -0.003 | -2 | 0.895 |
IKKE |
0.869 | -0.052 | 1 | 0.782 |
WNK3 |
0.869 | 0.048 | 1 | 0.888 |
PKCB |
0.869 | 0.268 | 2 | 0.780 |
PKCA |
0.869 | 0.243 | 2 | 0.773 |
PAK3 |
0.868 | 0.206 | -2 | 0.829 |
AKT2 |
0.868 | 0.415 | -3 | 0.842 |
CAMK2G |
0.868 | 0.008 | 2 | 0.879 |
BMPR2 |
0.868 | -0.067 | -2 | 0.911 |
PAK1 |
0.868 | 0.226 | -2 | 0.828 |
NUAK1 |
0.868 | 0.274 | -3 | 0.869 |
AMPKA2 |
0.868 | 0.270 | -3 | 0.864 |
PHKG1 |
0.868 | 0.249 | -3 | 0.859 |
PKCG |
0.868 | 0.239 | 2 | 0.787 |
PKG2 |
0.868 | 0.289 | -2 | 0.726 |
MLK1 |
0.867 | 0.001 | 2 | 0.838 |
MYLK4 |
0.867 | 0.310 | -2 | 0.816 |
ERK5 |
0.867 | 0.071 | 1 | 0.796 |
PDHK1 |
0.867 | -0.135 | 1 | 0.878 |
NEK7 |
0.867 | -0.081 | -3 | 0.765 |
CAMK4 |
0.867 | 0.193 | -3 | 0.853 |
SRPK3 |
0.866 | 0.312 | -3 | 0.869 |
SIK |
0.866 | 0.288 | -3 | 0.843 |
CHAK2 |
0.866 | 0.069 | -1 | 0.876 |
PAK6 |
0.866 | 0.182 | -2 | 0.758 |
MSK1 |
0.866 | 0.328 | -3 | 0.864 |
AURB |
0.865 | 0.212 | -2 | 0.704 |
RIPK1 |
0.865 | 0.074 | 1 | 0.901 |
CLK4 |
0.864 | 0.321 | -3 | 0.882 |
QIK |
0.864 | 0.184 | -3 | 0.850 |
CLK1 |
0.864 | 0.328 | -3 | 0.861 |
PRKX |
0.864 | 0.374 | -3 | 0.808 |
PKCH |
0.864 | 0.240 | 2 | 0.767 |
IRE1 |
0.864 | 0.089 | 1 | 0.879 |
NEK9 |
0.863 | -0.018 | 2 | 0.850 |
BCKDK |
0.863 | -0.075 | -1 | 0.861 |
MLK2 |
0.863 | 0.046 | 2 | 0.841 |
AKT1 |
0.862 | 0.387 | -3 | 0.839 |
ANKRD3 |
0.862 | 0.066 | 1 | 0.921 |
PKCZ |
0.862 | 0.191 | 2 | 0.815 |
MNK1 |
0.862 | 0.205 | -2 | 0.847 |
PAK2 |
0.862 | 0.188 | -2 | 0.822 |
MLK3 |
0.862 | 0.096 | 2 | 0.785 |
ULK1 |
0.862 | -0.113 | -3 | 0.752 |
QSK |
0.862 | 0.193 | 4 | 0.821 |
CAMK2B |
0.861 | 0.202 | 2 | 0.845 |
BRSK2 |
0.861 | 0.182 | -3 | 0.853 |
IRE2 |
0.861 | 0.094 | 2 | 0.780 |
TSSK1 |
0.860 | 0.151 | -3 | 0.875 |
MAPKAPK5 |
0.860 | 0.273 | -3 | 0.845 |
P70S6K |
0.860 | 0.347 | -3 | 0.850 |
MASTL |
0.860 | -0.090 | -2 | 0.890 |
LATS1 |
0.859 | 0.228 | -3 | 0.887 |
PKCT |
0.859 | 0.274 | 2 | 0.776 |
DYRK2 |
0.859 | 0.159 | 1 | 0.655 |
BRSK1 |
0.859 | 0.224 | -3 | 0.860 |
PKACA |
0.859 | 0.334 | -2 | 0.668 |
CAMK2A |
0.858 | 0.230 | 2 | 0.873 |
PKR |
0.858 | 0.157 | 1 | 0.910 |
TSSK2 |
0.858 | 0.084 | -5 | 0.777 |
GRK5 |
0.858 | -0.140 | -3 | 0.782 |
CAMK1G |
0.857 | 0.300 | -3 | 0.869 |
ATM |
0.857 | 0.062 | 1 | 0.826 |
AKT3 |
0.857 | 0.426 | -3 | 0.805 |
CHAK1 |
0.856 | 0.046 | 2 | 0.808 |
NEK2 |
0.856 | 0.023 | 2 | 0.834 |
DLK |
0.856 | -0.006 | 1 | 0.875 |
PHKG2 |
0.855 | 0.229 | -3 | 0.841 |
SMMLCK |
0.855 | 0.318 | -3 | 0.889 |
SNRK |
0.855 | 0.094 | 2 | 0.737 |
HUNK |
0.855 | -0.102 | 2 | 0.822 |
DCAMKL1 |
0.854 | 0.303 | -3 | 0.845 |
TTBK2 |
0.854 | -0.106 | 2 | 0.732 |
IRAK4 |
0.854 | 0.146 | 1 | 0.905 |
KIS |
0.853 | -0.007 | 1 | 0.635 |
IKKA |
0.853 | -0.077 | -2 | 0.791 |
MARK3 |
0.853 | 0.121 | 4 | 0.767 |
CAMK1D |
0.853 | 0.347 | -3 | 0.822 |
DYRK1A |
0.853 | 0.253 | 1 | 0.695 |
FAM20C |
0.852 | 0.052 | 2 | 0.644 |
GRK6 |
0.852 | -0.073 | 1 | 0.851 |
MARK2 |
0.852 | 0.101 | 4 | 0.738 |
SGK1 |
0.852 | 0.433 | -3 | 0.800 |
AURA |
0.852 | 0.152 | -2 | 0.669 |
CHK1 |
0.851 | 0.128 | -3 | 0.839 |
GRK1 |
0.851 | -0.007 | -2 | 0.836 |
HIPK3 |
0.851 | 0.204 | 1 | 0.700 |
WNK4 |
0.851 | 0.136 | -2 | 0.920 |
MARK1 |
0.851 | 0.118 | 4 | 0.798 |
CLK2 |
0.851 | 0.328 | -3 | 0.873 |
MLK4 |
0.851 | 0.012 | 2 | 0.763 |
PKCI |
0.851 | 0.223 | 2 | 0.781 |
HIPK1 |
0.851 | 0.217 | 1 | 0.670 |
MRCKA |
0.850 | 0.418 | -3 | 0.857 |
YSK4 |
0.850 | -0.020 | 1 | 0.826 |
GRK4 |
0.850 | -0.138 | -2 | 0.851 |
MRCKB |
0.850 | 0.397 | -3 | 0.847 |
DNAPK |
0.850 | 0.098 | 1 | 0.754 |
PKN1 |
0.850 | 0.326 | -3 | 0.847 |
PKCE |
0.849 | 0.290 | 2 | 0.766 |
PLK1 |
0.849 | -0.061 | -2 | 0.849 |
PAK5 |
0.848 | 0.173 | -2 | 0.704 |
SMG1 |
0.848 | 0.036 | 1 | 0.830 |
HIPK2 |
0.848 | 0.183 | 1 | 0.547 |
PLK4 |
0.848 | 0.007 | 2 | 0.672 |
DYRK3 |
0.848 | 0.254 | 1 | 0.694 |
ALK4 |
0.848 | -0.022 | -2 | 0.841 |
DCAMKL2 |
0.847 | 0.211 | -3 | 0.860 |
VRK2 |
0.847 | -0.048 | 1 | 0.911 |
PERK |
0.846 | -0.016 | -2 | 0.876 |
CDK7 |
0.846 | -0.004 | 1 | 0.591 |
MEK1 |
0.846 | -0.078 | 2 | 0.860 |
CHK2 |
0.846 | 0.373 | -3 | 0.797 |
ROCK2 |
0.845 | 0.396 | -3 | 0.863 |
DRAK1 |
0.845 | 0.067 | 1 | 0.764 |
HRI |
0.845 | -0.057 | -2 | 0.881 |
BMPR1B |
0.845 | 0.033 | 1 | 0.783 |
DAPK3 |
0.844 | 0.319 | -3 | 0.873 |
MST3 |
0.843 | 0.148 | 2 | 0.853 |
NEK5 |
0.843 | 0.028 | 1 | 0.910 |
TGFBR1 |
0.843 | -0.031 | -2 | 0.810 |
CDK8 |
0.843 | -0.064 | 1 | 0.588 |
ZAK |
0.843 | 0.009 | 1 | 0.849 |
TLK2 |
0.842 | -0.062 | 1 | 0.867 |
CDK18 |
0.842 | 0.024 | 1 | 0.507 |
CAMK1A |
0.842 | 0.340 | -3 | 0.799 |
PAK4 |
0.842 | 0.148 | -2 | 0.705 |
BRAF |
0.842 | 0.036 | -4 | 0.815 |
MEKK1 |
0.841 | -0.051 | 1 | 0.890 |
PLK3 |
0.841 | -0.075 | 2 | 0.831 |
MEKK2 |
0.841 | 0.018 | 2 | 0.826 |
MEK5 |
0.841 | -0.039 | 2 | 0.852 |
ALK2 |
0.841 | -0.002 | -2 | 0.823 |
P38A |
0.840 | 0.015 | 1 | 0.648 |
TAO3 |
0.839 | 0.090 | 1 | 0.846 |
ACVR2A |
0.839 | -0.052 | -2 | 0.800 |
MAK |
0.838 | 0.330 | -2 | 0.816 |
MEKK3 |
0.838 | -0.080 | 1 | 0.870 |
DYRK1B |
0.838 | 0.136 | 1 | 0.586 |
PASK |
0.838 | 0.207 | -3 | 0.884 |
DYRK4 |
0.838 | 0.120 | 1 | 0.551 |
CDK14 |
0.837 | 0.069 | 1 | 0.555 |
DMPK1 |
0.837 | 0.405 | -3 | 0.850 |
TLK1 |
0.837 | -0.056 | -2 | 0.836 |
MOK |
0.836 | 0.330 | 1 | 0.714 |
NEK8 |
0.836 | 0.032 | 2 | 0.849 |
ACVR2B |
0.836 | -0.060 | -2 | 0.814 |
CDK19 |
0.836 | -0.060 | 1 | 0.543 |
CDK5 |
0.836 | -0.014 | 1 | 0.613 |
IRAK1 |
0.836 | -0.085 | -1 | 0.829 |
PKG1 |
0.836 | 0.265 | -2 | 0.628 |
GRK7 |
0.836 | -0.010 | 1 | 0.766 |
SSTK |
0.836 | 0.058 | 4 | 0.819 |
PDK1 |
0.836 | 0.148 | 1 | 0.852 |
MPSK1 |
0.835 | 0.069 | 1 | 0.803 |
ROCK1 |
0.835 | 0.369 | -3 | 0.849 |
LOK |
0.835 | 0.165 | -2 | 0.856 |
TAO2 |
0.834 | 0.074 | 2 | 0.882 |
DAPK1 |
0.834 | 0.280 | -3 | 0.872 |
TTBK1 |
0.834 | -0.102 | 2 | 0.662 |
NEK4 |
0.833 | 0.021 | 1 | 0.879 |
CDK13 |
0.833 | -0.081 | 1 | 0.560 |
PRP4 |
0.833 | -0.013 | -3 | 0.711 |
CAMKK1 |
0.833 | -0.056 | -2 | 0.818 |
JNK2 |
0.832 | -0.009 | 1 | 0.529 |
CDK17 |
0.832 | -0.017 | 1 | 0.441 |
LKB1 |
0.832 | 0.044 | -3 | 0.768 |
P38B |
0.832 | -0.004 | 1 | 0.555 |
SBK |
0.831 | 0.360 | -3 | 0.766 |
ERK1 |
0.831 | -0.031 | 1 | 0.546 |
CDK1 |
0.831 | -0.034 | 1 | 0.524 |
PINK1 |
0.830 | -0.179 | 1 | 0.806 |
NEK11 |
0.830 | -0.056 | 1 | 0.834 |
CAMKK2 |
0.830 | -0.020 | -2 | 0.825 |
HGK |
0.830 | 0.064 | 3 | 0.874 |
CDK9 |
0.830 | -0.068 | 1 | 0.575 |
NEK1 |
0.829 | 0.073 | 1 | 0.897 |
BMPR1A |
0.829 | 0.006 | 1 | 0.771 |
ERK2 |
0.829 | -0.059 | 1 | 0.597 |
TNIK |
0.829 | 0.102 | 3 | 0.873 |
CDK10 |
0.829 | 0.089 | 1 | 0.539 |
MEKK6 |
0.829 | 0.062 | 1 | 0.871 |
CDK16 |
0.828 | 0.045 | 1 | 0.459 |
GCK |
0.827 | 0.074 | 1 | 0.832 |
CRIK |
0.827 | 0.354 | -3 | 0.852 |
MAP3K15 |
0.827 | 0.037 | 1 | 0.836 |
LRRK2 |
0.827 | 0.079 | 2 | 0.879 |
CDK12 |
0.827 | -0.068 | 1 | 0.533 |
CDK2 |
0.827 | -0.071 | 1 | 0.624 |
JNK3 |
0.826 | -0.066 | 1 | 0.567 |
MINK |
0.826 | 0.031 | 1 | 0.855 |
EEF2K |
0.826 | 0.033 | 3 | 0.821 |
SLK |
0.825 | 0.068 | -2 | 0.807 |
HPK1 |
0.825 | 0.087 | 1 | 0.815 |
MST2 |
0.824 | -0.039 | 1 | 0.865 |
YSK1 |
0.824 | 0.088 | 2 | 0.826 |
CK1E |
0.824 | -0.087 | -3 | 0.450 |
ERK7 |
0.824 | 0.035 | 2 | 0.581 |
BUB1 |
0.824 | 0.133 | -5 | 0.703 |
STK33 |
0.823 | -0.036 | 2 | 0.666 |
GRK2 |
0.823 | -0.134 | -2 | 0.731 |
VRK1 |
0.823 | 0.015 | 2 | 0.852 |
RIPK2 |
0.823 | -0.080 | 1 | 0.824 |
GAK |
0.823 | 0.005 | 1 | 0.840 |
TAK1 |
0.822 | 0.006 | 1 | 0.869 |
KHS1 |
0.822 | 0.099 | 1 | 0.833 |
KHS2 |
0.822 | 0.123 | 1 | 0.828 |
P38G |
0.822 | -0.049 | 1 | 0.440 |
NEK3 |
0.820 | -0.007 | 1 | 0.864 |
CDK3 |
0.819 | -0.012 | 1 | 0.460 |
MST1 |
0.819 | -0.010 | 1 | 0.856 |
CK1G1 |
0.819 | -0.105 | -3 | 0.457 |
PBK |
0.819 | 0.072 | 1 | 0.788 |
MEK2 |
0.818 | -0.107 | 2 | 0.825 |
TTK |
0.816 | 0.089 | -2 | 0.853 |
P38D |
0.814 | -0.044 | 1 | 0.477 |
CDK4 |
0.813 | -0.007 | 1 | 0.514 |
GSK3B |
0.813 | -0.076 | 4 | 0.382 |
CK1D |
0.813 | -0.105 | -3 | 0.399 |
CDK6 |
0.812 | -0.032 | 1 | 0.542 |
CK1A2 |
0.811 | -0.103 | -3 | 0.404 |
MYO3B |
0.811 | 0.067 | 2 | 0.844 |
TAO1 |
0.810 | 0.054 | 1 | 0.806 |
GSK3A |
0.809 | -0.058 | 4 | 0.391 |
PLK2 |
0.808 | -0.099 | -3 | 0.696 |
HASPIN |
0.808 | 0.054 | -1 | 0.718 |
GRK3 |
0.806 | -0.148 | -2 | 0.682 |
MYO3A |
0.805 | 0.029 | 1 | 0.854 |
OSR1 |
0.804 | -0.041 | 2 | 0.812 |
PDHK3_TYR |
0.804 | 0.105 | 4 | 0.900 |
TESK1_TYR |
0.802 | 0.116 | 3 | 0.906 |
ASK1 |
0.800 | -0.052 | 1 | 0.810 |
LIMK2_TYR |
0.800 | 0.175 | -3 | 0.843 |
RET |
0.799 | 0.108 | 1 | 0.875 |
CK2A2 |
0.798 | -0.082 | 1 | 0.651 |
JNK1 |
0.798 | -0.095 | 1 | 0.495 |
TNK2 |
0.798 | 0.173 | 3 | 0.840 |
BIKE |
0.798 | -0.003 | 1 | 0.702 |
MAP2K7_TYR |
0.797 | -0.035 | 2 | 0.901 |
EPHB4 |
0.797 | 0.116 | -1 | 0.872 |
EPHA6 |
0.797 | 0.107 | -1 | 0.858 |
TYRO3 |
0.796 | 0.076 | 3 | 0.855 |
PKMYT1_TYR |
0.796 | 0.009 | 3 | 0.891 |
MAP2K4_TYR |
0.795 | -0.041 | -1 | 0.901 |
ALPHAK3 |
0.795 | -0.042 | -1 | 0.785 |
PINK1_TYR |
0.794 | -0.004 | 1 | 0.864 |
MST1R |
0.794 | 0.042 | 3 | 0.870 |
ROS1 |
0.793 | 0.042 | 3 | 0.833 |
TYK2 |
0.793 | -0.023 | 1 | 0.877 |
PDHK4_TYR |
0.792 | -0.049 | 2 | 0.927 |
ABL2 |
0.792 | 0.077 | -1 | 0.865 |
TNK1 |
0.792 | 0.124 | 3 | 0.833 |
JAK2 |
0.791 | -0.022 | 1 | 0.871 |
LIMK1_TYR |
0.791 | -0.023 | 2 | 0.885 |
MAP2K6_TYR |
0.791 | -0.098 | -1 | 0.881 |
DDR1 |
0.790 | 0.029 | 4 | 0.829 |
YANK3 |
0.790 | -0.062 | 2 | 0.445 |
AXL |
0.789 | 0.079 | 3 | 0.852 |
PDGFRB |
0.789 | 0.029 | 3 | 0.866 |
TXK |
0.789 | 0.109 | 1 | 0.850 |
ITK |
0.789 | 0.074 | -1 | 0.856 |
CK2A1 |
0.789 | -0.097 | 1 | 0.626 |
CSF1R |
0.789 | -0.005 | 3 | 0.859 |
PDHK1_TYR |
0.788 | -0.114 | -1 | 0.886 |
ABL1 |
0.788 | 0.054 | -1 | 0.870 |
TNNI3K_TYR |
0.788 | 0.093 | 1 | 0.917 |
EPHB1 |
0.788 | 0.058 | 1 | 0.905 |
YES1 |
0.787 | 0.038 | -1 | 0.893 |
TEC |
0.787 | 0.096 | -1 | 0.849 |
BMPR2_TYR |
0.787 | -0.104 | -1 | 0.844 |
STLK3 |
0.786 | -0.147 | 1 | 0.830 |
SRMS |
0.786 | 0.032 | 1 | 0.888 |
EPHB3 |
0.785 | 0.048 | -1 | 0.860 |
JAK3 |
0.785 | -0.014 | 1 | 0.847 |
JAK1 |
0.784 | 0.040 | 1 | 0.823 |
MERTK |
0.784 | 0.046 | 3 | 0.842 |
DDR2 |
0.784 | 0.169 | 3 | 0.806 |
LTK |
0.783 | 0.052 | 3 | 0.811 |
FER |
0.783 | -0.076 | 1 | 0.900 |
EPHB2 |
0.783 | 0.040 | -1 | 0.852 |
LCK |
0.783 | 0.042 | -1 | 0.842 |
FGR |
0.783 | -0.056 | 1 | 0.895 |
HCK |
0.782 | -0.019 | -1 | 0.859 |
NEK10_TYR |
0.782 | 0.010 | 1 | 0.714 |
EPHA4 |
0.782 | -0.002 | 2 | 0.828 |
BTK |
0.782 | -0.012 | -1 | 0.857 |
KDR |
0.782 | 0.022 | 3 | 0.825 |
EPHA1 |
0.781 | 0.077 | 3 | 0.837 |
FLT3 |
0.781 | -0.038 | 3 | 0.847 |
INSRR |
0.781 | -0.025 | 3 | 0.806 |
BLK |
0.780 | 0.057 | -1 | 0.849 |
TEK |
0.780 | -0.018 | 3 | 0.801 |
ALK |
0.780 | 0.003 | 3 | 0.787 |
FGFR2 |
0.780 | -0.041 | 3 | 0.849 |
BMX |
0.779 | 0.031 | -1 | 0.773 |
PDGFRA |
0.779 | -0.061 | 3 | 0.861 |
EPHA7 |
0.779 | 0.038 | 2 | 0.832 |
KIT |
0.778 | -0.072 | 3 | 0.860 |
FGFR1 |
0.777 | -0.059 | 3 | 0.836 |
AAK1 |
0.777 | 0.009 | 1 | 0.588 |
PTK6 |
0.775 | -0.088 | -1 | 0.805 |
MET |
0.775 | -0.041 | 3 | 0.855 |
WEE1_TYR |
0.774 | -0.039 | -1 | 0.813 |
EPHA3 |
0.774 | -0.037 | 2 | 0.811 |
PTK2B |
0.773 | 0.042 | -1 | 0.871 |
NTRK2 |
0.772 | -0.082 | 3 | 0.819 |
NTRK1 |
0.772 | -0.123 | -1 | 0.855 |
LYN |
0.770 | -0.032 | 3 | 0.779 |
FRK |
0.770 | -0.044 | -1 | 0.872 |
EPHA5 |
0.769 | 0.001 | 2 | 0.825 |
CK1A |
0.768 | -0.155 | -3 | 0.311 |
FYN |
0.767 | -0.029 | -1 | 0.802 |
FLT1 |
0.767 | -0.091 | -1 | 0.810 |
FLT4 |
0.766 | -0.108 | 3 | 0.813 |
INSR |
0.766 | -0.104 | 3 | 0.786 |
FGFR3 |
0.766 | -0.098 | 3 | 0.825 |
ERBB2 |
0.765 | -0.150 | 1 | 0.794 |
NTRK3 |
0.763 | -0.118 | -1 | 0.796 |
EPHA8 |
0.762 | -0.062 | -1 | 0.806 |
MATK |
0.762 | -0.105 | -1 | 0.778 |
CSK |
0.758 | -0.124 | 2 | 0.827 |
SRC |
0.758 | -0.081 | -1 | 0.829 |
CK1G3 |
0.755 | -0.141 | -3 | 0.267 |
YANK2 |
0.755 | -0.107 | 2 | 0.460 |
FGFR4 |
0.753 | -0.113 | -1 | 0.798 |
EPHA2 |
0.753 | -0.060 | -1 | 0.772 |
EGFR |
0.752 | -0.125 | 1 | 0.702 |
MUSK |
0.749 | -0.140 | 1 | 0.702 |
IGF1R |
0.747 | -0.145 | 3 | 0.725 |
PTK2 |
0.746 | -0.078 | -1 | 0.728 |
SYK |
0.740 | -0.128 | -1 | 0.718 |
FES |
0.739 | -0.124 | -1 | 0.763 |
ERBB4 |
0.735 | -0.130 | 1 | 0.691 |
CK1G2 |
0.724 | -0.169 | -3 | 0.364 |
ZAP70 |
0.720 | -0.119 | -1 | 0.652 |