Motif 803 (n=192)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A4UGR9 | XIRP2 | S2321 | ochoa | Xin actin-binding repeat-containing protein 2 (Beta-xin) (Cardiomyopathy-associated protein 3) (Xeplin) | Protects actin filaments from depolymerization (PubMed:15454575). Required for correct morphology of cell membranes and maturation of intercalated disks of cardiomyocytes via facilitating localization of XIRP1 and CDH2 to the termini of aligned mature cardiomyocytes (By similarity). Thereby required for correct postnatal heart development and growth regulation that is crucial for overall heart morphology and diastolic function (By similarity). Required for normal electrical conduction in the heart including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with the cardiac ion channel components Scn5a/Nav1.5 and Kcna5/Kv1.5 (By similarity). Required for regular actin filament spacing of the paracrystalline array in both inner and outer hair cells of the cochlea, thereby required for maintenance of stereocilia morphology (By similarity). {ECO:0000250|UniProtKB:Q4U4S6, ECO:0000269|PubMed:15454575}. |
| B2RTY4 | MYO9A | S1349 | ochoa | Unconventional myosin-IXa (Unconventional myosin-9a) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating it's GTPase activity in neurons. Required for the regulation of neurite branching and motor neuron axon guidance (By similarity). {ECO:0000250|UniProtKB:Q8C170, ECO:0000250|UniProtKB:Q9Z1N3}. |
| E9PCH4 | None | S1487 | ochoa | Rap guanine nucleotide exchange factor 6 | None |
| O14813 | PHOX2A | S153 | psp | Paired mesoderm homeobox protein 2A (ARIX1 homeodomain protein) (Aristaless homeobox protein homolog) (Paired-like homeobox 2A) | May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype. |
| O14893 | GEMIN2 | S85 | ochoa | Gem-associated protein 2 (Gemin-2) (Component of gems 2) (Survival of motor neuron protein-interacting protein 1) (SMN-interacting protein 1) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:18984161, PubMed:9323129). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) (PubMed:18984161). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG (5Sm) are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:18984161). To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A (PubMed:18984161, PubMed:9323129). Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP (PubMed:31799625). Within the SMN complex, GEMIN2 constrains the conformation of 5Sm, thereby promoting 5Sm binding to snRNA containing the snRNP code (a nonameric Sm site and a 3'-adjacent stem-loop), thus preventing progression of assembly until a cognate substrate is bound (PubMed:16314521, PubMed:21816274, PubMed:31799625). {ECO:0000269|PubMed:16314521, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:21816274, ECO:0000269|PubMed:31799625, ECO:0000269|PubMed:9323129}. |
| O15355 | PPM1G | S527 | ochoa | Protein phosphatase 1G (EC 3.1.3.16) (Protein phosphatase 1C) (Protein phosphatase 2C isoform gamma) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma) | None |
| O15504 | NUP42 | S98 | ochoa | Nucleoporin NUP42 (NLP-1) (NUP42 homolog) (Nucleoporin hCG1) (Nucleoporin-42) (Nucleoporin-like protein 2) | Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. {ECO:0000269|PubMed:10610322, ECO:0000269|PubMed:16000379}.; FUNCTION: (Microbial infection) In case of infection by HIV-1, it may participate in the docking of viral Vpr at the nuclear envelope. {ECO:0000269|PubMed:12228227}. |
| O60502 | OGA | S364 | ochoa | Protein O-GlcNAcase (OGA) (EC 3.2.1.169) (Beta-N-acetylglucosaminidase) (Beta-N-acetylhexosaminidase) (Beta-hexosaminidase) (Meningioma-expressed antigen 5) (N-acetyl-beta-D-glucosaminidase) (N-acetyl-beta-glucosaminidase) (Nuclear cytoplasmic O-GlcNAcase and acetyltransferase) (NCOAT) | [Isoform 1]: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins (PubMed:11148210, PubMed:11788610, PubMed:20673219, PubMed:22365600, PubMed:24088714, PubMed:28939839, PubMed:37962578). Deglycosylates a large and diverse number of proteins, such as CRYAB, ELK1, GSDMD, LMNB1 and TAB1 (PubMed:28939839, PubMed:37962578). Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:20673219). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714). {ECO:0000269|PubMed:11148210, ECO:0000269|PubMed:11788610, ECO:0000269|PubMed:20673219, ECO:0000269|PubMed:22365600, ECO:0000269|PubMed:24088714, ECO:0000269|PubMed:28939839, ECO:0000269|PubMed:37962578}.; FUNCTION: [Isoform 3]: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1. {ECO:0000269|PubMed:20673219}. |
| O60503 | ADCY9 | S354 | ochoa | Adenylate cyclase type 9 (EC 4.6.1.1) (ATP pyrophosphate-lyase 9) (Adenylate cyclase type IX) (ACIX) (Adenylyl cyclase 9) (AC9) | Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors (PubMed:10987815, PubMed:12972952, PubMed:15879435, PubMed:9628827). Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors (PubMed:9628827). {ECO:0000269|PubMed:10987815, ECO:0000269|PubMed:12972952, ECO:0000269|PubMed:15879435, ECO:0000269|PubMed:9628827}. |
| O60934 | NBN | S447 | ochoa | Nibrin (Cell cycle regulatory protein p95) (Nijmegen breakage syndrome protein 1) (hNbs1) | Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:10888888, PubMed:15616588, PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:19759395, PubMed:23115235, PubMed:28216226, PubMed:28867292, PubMed:9705271). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (PubMed:19759395, PubMed:28867292, PubMed:9705271). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (PubMed:19759395, PubMed:9705271). The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination (PubMed:19759395, PubMed:28867292, PubMed:9705271). Within the MRN complex, NBN acts as a protein-protein adapter, which specifically recognizes and binds phosphorylated proteins, promoting their recruitment to DNA damage sites (PubMed:12419185, PubMed:15616588, PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890, PubMed:19759395, PubMed:19804756, PubMed:23762398, PubMed:24534091, PubMed:27814491, PubMed:27889449, PubMed:33836577). Recruits MRE11 and RAD50 components of the MRN complex to DSBs in response to DNA damage (PubMed:12419185, PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:24534091, PubMed:26438602). Promotes the recruitment of PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites, activating their functions (PubMed:15064416, PubMed:15616588, PubMed:15790808, PubMed:16622404, PubMed:22464731, PubMed:30952868, PubMed:35076389). Mediates the recruitment of phosphorylated RBBP8/CtIP to DSBs, leading to cooperation between the MRN complex and RBBP8/CtIP to initiate end resection (PubMed:19759395, PubMed:27814491, PubMed:27889449, PubMed:33836577). RBBP8/CtIP specifically promotes the endonuclease activity of the MRN complex to clear DNA ends containing protein adducts (PubMed:27814491, PubMed:27889449, PubMed:30787182, PubMed:33836577). The MRN complex is also required for the processing of R-loops (PubMed:31537797). NBN also functions in telomere length maintenance via its interaction with TERF2: interaction with TERF2 during G1 phase preventing recruitment of DCLRE1B/Apollo to telomeres (PubMed:10888888, PubMed:28216226). NBN also promotes DNA repair choice at dysfunctional telomeres: NBN phosphorylation by CDK2 promotes non-homologous end joining repair at telomeres, while unphosphorylated NBN promotes microhomology-mediated end-joining (MMEJ) repair (PubMed:28216226). Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex (PubMed:23762398). {ECO:0000269|PubMed:10888888, ECO:0000269|PubMed:12419185, ECO:0000269|PubMed:15064416, ECO:0000269|PubMed:15616588, ECO:0000269|PubMed:15790808, ECO:0000269|PubMed:16622404, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:19759395, ECO:0000269|PubMed:19804756, ECO:0000269|PubMed:22464731, ECO:0000269|PubMed:23115235, ECO:0000269|PubMed:23762398, ECO:0000269|PubMed:24534091, ECO:0000269|PubMed:26438602, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:28216226, ECO:0000269|PubMed:28867292, ECO:0000269|PubMed:30787182, ECO:0000269|PubMed:30952868, ECO:0000269|PubMed:31537797, ECO:0000269|PubMed:33836577, ECO:0000269|PubMed:35076389, ECO:0000269|PubMed:9705271}. |
| O75400 | PRPF40A | S194 | ochoa | Pre-mRNA-processing factor 40 homolog A (Fas ligand-associated factor 1) (Formin-binding protein 11) (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein 10) (HIP-10) (Huntingtin-interacting protein A) (Renal carcinoma antigen NY-REN-6) | Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing. {ECO:0000250, ECO:0000269|PubMed:21834987}. |
| O75643 | SNRNP200 | S457 | ochoa | U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.4.13) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog) (U5 snRNP-specific 200 kDa protein) (U5-200KD) | Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome (PubMed:35241646). Plays a role in pre-mRNA splicing as a core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:28502770, PubMed:28781166, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30315277, PubMed:30705154, PubMed:30728453). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. {ECO:0000269|PubMed:16723661, ECO:0000269|PubMed:23045696, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:30728453, ECO:0000269|PubMed:35241646, ECO:0000269|PubMed:8670905, ECO:0000269|PubMed:9539711, ECO:0000305|PubMed:33509932}. |
| O75940 | SMNDC1 | S201 | ochoa | Survival of motor neuron-related-splicing factor 30 (30 kDa splicing factor SMNrp) (SMN-related protein) (Survival motor neuron domain-containing protein 1) | Involved in spliceosome assembly. {ECO:0000269|PubMed:11331295, ECO:0000269|PubMed:11331595, ECO:0000269|PubMed:9817934}. |
| O76041 | NEBL | S817 | ochoa | Nebulette (Actin-binding Z-disk protein) | Binds to actin and plays an important role in the assembly of the Z-disk. May functionally link sarcomeric actin to the desmin intermediate filaments in the heart muscle sarcomeres (PubMed:27733623). {ECO:0000269|PubMed:27733623}.; FUNCTION: [Isoform 2]: May play a role in the assembly of focal adhesions. {ECO:0000269|PubMed:15004028}. |
| O94782 | USP1 | S42 | ochoa|psp | Ubiquitin carboxyl-terminal hydrolase 1 (EC 3.4.19.12) (Deubiquitinating enzyme 1) (hUBP) (Ubiquitin thioesterase 1) (Ubiquitin-specific-processing protease 1) [Cleaved into: Ubiquitin carboxyl-terminal hydrolase 1, N-terminal fragment] | Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2 (PubMed:15694335). Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (PubMed:16531995, PubMed:20147293). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:18082604, PubMed:26388029). {ECO:0000269|PubMed:15694335, ECO:0000269|PubMed:16531995, ECO:0000269|PubMed:18082604, ECO:0000269|PubMed:20147293, ECO:0000269|PubMed:26388029}. |
| O94885 | SASH1 | S135 | ochoa | SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) | Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). {ECO:0000269|PubMed:23333244, ECO:0000269|PubMed:23776175, ECO:0000269|PubMed:25315659}. |
| O94921 | CDK14 | S134 | ochoa | Cyclin-dependent kinase 14 (EC 2.7.11.22) (Cell division protein kinase 14) (Serine/threonine-protein kinase PFTAIRE-1) (hPFTAIRE1) | Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport. {ECO:0000269|PubMed:16461467, ECO:0000269|PubMed:17517622, ECO:0000269|PubMed:19524571, ECO:0000269|PubMed:20059949}. |
| O95433 | AHSA1 | S193 | ochoa | Activator of 90 kDa heat shock protein ATPase homolog 1 (AHA1) (p38) | Acts as a co-chaperone of HSP90AA1 (PubMed:29127155). Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity (PubMed:29127155). Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360). Competes with the inhibitory co-chaperone TSC1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155). {ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155}. |
| O95835 | LATS1 | S181 | ochoa | Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts) | Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:10518011, PubMed:10831611, PubMed:18158288, PubMed:26437443, PubMed:28068668). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288, PubMed:26437443, PubMed:28068668). Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:18158288, PubMed:26437443, PubMed:28068668). Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint (PubMed:15122335, PubMed:19927127). Negatively regulates G2/M transition by down-regulating CDK1 kinase activity (PubMed:9988268). Involved in the control of p53 expression (PubMed:15122335). Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1 (PubMed:15220930). May also play a role in endocrine function. Plays a role in mammary gland epithelial cell differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1 (PubMed:28068668). Acts as an activator of the NLRP3 inflammasome by mediating phosphorylation of 'Ser-265' of NLRP3 following NLRP3 palmitoylation, promoting NLRP3 activation by NEK7 (PubMed:39173637). {ECO:0000269|PubMed:10518011, ECO:0000269|PubMed:10831611, ECO:0000269|PubMed:15122335, ECO:0000269|PubMed:15220930, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:28068668, ECO:0000269|PubMed:39173637, ECO:0000269|PubMed:9988268}. |
| O95997 | PTTG1 | S31 | psp | Securin (Esp1-associated protein) (Pituitary tumor-transforming gene 1 protein) (Tumor-transforming protein 1) (hPTTG) | Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation. {ECO:0000269|PubMed:10411507, ECO:0000269|PubMed:11238996, ECO:0000269|PubMed:11371342, ECO:0000269|PubMed:12355087}. |
| P06241 | FYN | Y213 | ochoa|psp | Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn) | Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance (PubMed:11536198, PubMed:15489916, PubMed:15557120, PubMed:16387660, PubMed:20100835, PubMed:7568038, PubMed:7822789). Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain (PubMed:15489916). Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions (PubMed:15489916). Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin) (PubMed:17194753). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT (PubMed:14707117, PubMed:15536091). Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage (PubMed:16841086). Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6 (PubMed:14761972, PubMed:18258597, PubMed:19179337). Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein (PubMed:11162638, PubMed:12788081, PubMed:19652227). Involved in reelin signaling by mediating phosphorylation of DAB1 following reelin (RELN)-binding to its receptor (By similarity). Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation (PubMed:22080863). Phosphorylates PTK2B/PYK2 in response to T-cell receptor activation (PubMed:20028775). Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts (PubMed:18056706). CSK maintains LCK and FYN in an inactive form (By similarity). Promotes CD28-induced phosphorylation of VAV1 (PubMed:11005864). In mast cells, phosphorylates CLNK after activation of immunoglobulin epsilon receptor signaling (By similarity). Can also promote CD244-mediated NK cell activation (PubMed:15713798). {ECO:0000250|UniProtKB:P39688, ECO:0000269|PubMed:11005864, ECO:0000269|PubMed:11162638, ECO:0000269|PubMed:11536198, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:14707117, ECO:0000269|PubMed:14761972, ECO:0000269|PubMed:15536091, ECO:0000269|PubMed:15557120, ECO:0000269|PubMed:15713798, ECO:0000269|PubMed:16387660, ECO:0000269|PubMed:16841086, ECO:0000269|PubMed:17194753, ECO:0000269|PubMed:18056706, ECO:0000269|PubMed:18258597, ECO:0000269|PubMed:19179337, ECO:0000269|PubMed:19652227, ECO:0000269|PubMed:20028775, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:22080863, ECO:0000269|PubMed:7568038, ECO:0000269|PubMed:7822789, ECO:0000303|PubMed:15489916}. |
| P06733 | ENO1 | S291 | ochoa | Alpha-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (C-myc promoter-binding protein) (Enolase 1) (MBP-1) (MPB-1) (Non-neural enolase) (NNE) (Phosphopyruvate hydratase) (Plasminogen-binding protein) | Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (PubMed:1369209, PubMed:29775581). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses (PubMed:10802057, PubMed:12666133, PubMed:2005901, PubMed:29775581). May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (PubMed:12666133). Stimulates immunoglobulin production (PubMed:1369209). {ECO:0000269|PubMed:10802057, ECO:0000269|PubMed:12666133, ECO:0000269|PubMed:1369209, ECO:0000269|PubMed:2005901, ECO:0000269|PubMed:29775581}.; FUNCTION: [Isoform MBP-1]: Binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor. {ECO:0000269|PubMed:10082554}. |
| P07947 | YES1 | Y222 | ochoa | Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes) | Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGFR, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis. Catalyzes phosphorylation of organic cation transporter OCT2 which induces its transport activity (PubMed:26979622). {ECO:0000269|PubMed:11901164, ECO:0000269|PubMed:18479465, ECO:0000269|PubMed:19276087, ECO:0000269|PubMed:21566460, ECO:0000269|PubMed:21713032, ECO:0000269|PubMed:26979622}. |
| P09769 | FGR | Y208 | ochoa | Tyrosine-protein kinase Fgr (EC 2.7.10.2) (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog) (Proto-oncogene c-Fgr) (p55-Fgr) (p58-Fgr) (p58c-Fgr) | Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as a negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as a positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1. Together with CLNK, it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production (By similarity). {ECO:0000250|UniProtKB:P14234, ECO:0000269|PubMed:10739672, ECO:0000269|PubMed:17164290, ECO:0000269|PubMed:1737799, ECO:0000269|PubMed:7519620}. |
| P0C0L4 | C4A | S77 | ochoa | Complement C4-A (Acidic complement C4) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2) [Cleaved into: Complement C4 beta chain; Complement C4-A alpha chain; C4a anaphylatoxin; Complement C4b-A (Complement C4b-alpha' chain); Complement C4d-A; Complement C4 gamma chain] | Precursor of non-enzymatic components of the classical, lectin and GZMK complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. {ECO:0000269|PubMed:12878586, ECO:0000269|PubMed:18204047, ECO:0000269|PubMed:22949645, ECO:0000269|PubMed:2395880, ECO:0000269|PubMed:32769120, ECO:0000269|PubMed:35428691, ECO:0000269|PubMed:39914456, ECO:0000269|PubMed:8538770}.; FUNCTION: [Complement C4b-A]: Non-enzymatic component of C3 and C5 convertases (PubMed:8538770). Generated following cleavage by complement proteases (C1S, MASP2 or GZMK, depending on the complement pathway), it covalently attaches to the surface of pathogens, where it acts as an opsonin that marks the surface of antigens for removal (PubMed:27738201, PubMed:8538770). It then recruits the serine protease complement C2b to form the C3 and C5 convertases, which cleave and activate C3 and C5, respectively, the next components of the complement pathways (PubMed:12878586, PubMed:18204047, PubMed:2387864, PubMed:6906228). Complement C4b-A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while complement C4b-B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens (PubMed:8538770). {ECO:0000269|PubMed:12878586, ECO:0000269|PubMed:18204047, ECO:0000269|PubMed:2387864, ECO:0000269|PubMed:27738201, ECO:0000269|PubMed:6906228, ECO:0000269|PubMed:8538770}.; FUNCTION: [C4a anaphylatoxin]: Putative humoral mediator released following cleavage by complement proteases (C1S, MASP2 or GZMK, depending on the complement pathway) (PubMed:6167582). While it is strongly similar to anaphylatoxins, its role is unclear (PubMed:25659340). Was reported to act as a mediator of local inflammatory process; however these effects were probably due to contamination with C3a and/C5a anaphylatoxins in biological assays (PubMed:25659340). {ECO:0000269|PubMed:6167582, ECO:0000303|PubMed:25659340}. |
| P0C0L5 | C4B | S77 | ochoa | Complement C4-B (Basic complement C4) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3) [Cleaved into: Complement C4 beta chain; Complement C4-B alpha chain; C4a anaphylatoxin; Complement C4b-B; C4d-B; Complement C4 gamma chain] | Precursor of non-enzymatic components of the classical, lectin and GZMK complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. {ECO:0000269|PubMed:2395880, ECO:0000269|PubMed:8538770}.; FUNCTION: [Complement C4b-B]: Non-enzymatic component of C3 and C5 convertases (By similarity). Generated following cleavage by complement proteases (C1S, MASP2 or GZMK, depending on the complement pathway), it covalently attaches to the surface of pathogens, where it acts as an opsonin that marks the surface of antigens for removal (By similarity). It then recruits the serine protease complement C2b to form the C3 and C5 convertases, which cleave and activate C3 and C5, respectively, the next components of the complement pathways (PubMed:8538770). Complement C4b-B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens, while C4b-A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens (PubMed:8538770). {ECO:0000250|UniProtKB:P0C0L4, ECO:0000269|PubMed:8538770}.; FUNCTION: [C4a anaphylatoxin]: Putative humoral mediator released following cleavage by complement proteases (C1S, MASP2 or GZMK, depending on the complement pathway). While it is strongly similar to anaphylatoxins, its role is unclear. Was reported to act as a mediator of local inflammatory process; however these effects were probably due to contamination with C3a and/C5a anaphylatoxins in biological assays. {ECO:0000250|UniProtKB:P0C0L4}. |
| P12882 | MYH1 | S1603 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P15311 | EZR | S66 | psp | Ezrin (Cytovillin) (Villin-2) (p81) | Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis. {ECO:0000269|PubMed:17881735, ECO:0000269|PubMed:18270268, ECO:0000269|PubMed:19111582}. |
| P15822 | HIVEP1 | S1036 | ochoa | Zinc finger protein 40 (Cirhin interaction protein) (CIRIP) (Gate keeper of apoptosis-activating protein) (GAAP) (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis. |
| P18846 | ATF1 | S72 | ochoa | Cyclic AMP-dependent transcription factor ATF-1 (cAMP-dependent transcription factor ATF-1) (Activating transcription factor 1) (Protein TREB36) | This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation. {ECO:0000269|PubMed:18794154, ECO:0000269|PubMed:20980392}. |
| P20265 | POU3F2 | S360 | psp | POU domain, class 3, transcription factor 2 (Brain-specific homeobox/POU domain protein 2) (Brain-2) (Brn-2) (Nervous system-specific octamer-binding transcription factor N-Oct-3) (Octamer-binding protein 7) (Oct-7) (Octamer-binding transcription factor 7) (OTF-7) | Transcription factor that plays a key role in neuronal differentiation (By similarity). Binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides (By similarity). Acts as a transcriptional activator when binding cooperatively with SOX4, SOX11, or SOX12 to gene promoters (By similarity). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro (By similarity). Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL1, and promotes transcription of neuronal genes (By similarity). {ECO:0000250|UniProtKB:P31360, ECO:0000250|UniProtKB:P56222}. |
| P20810 | CAST | S87 | ochoa | Calpastatin (Calpain inhibitor) (Sperm BS-17 component) | Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. |
| P20929 | NEB | S1836 | ochoa | Nebulin | This giant muscle protein may be involved in maintaining the structural integrity of sarcomeres and the membrane system associated with the myofibrils. Binds and stabilize F-actin. |
| P20929 | NEB | S1865 | ochoa | Nebulin | This giant muscle protein may be involved in maintaining the structural integrity of sarcomeres and the membrane system associated with the myofibrils. Binds and stabilize F-actin. |
| P23025 | XPA | S196 | ochoa|psp | DNA repair protein complementing XP-A cells (Xeroderma pigmentosum group A-complementing protein) | Involved in DNA nucleotide excision repair (NER). Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation (PubMed:19197159). During NER stimulates the 5'-3' helicase activity of XPD/ERCC2 and the DNA translocase activity of XPB/ERCC3 (PubMed:31253769). Connects XPD/ERCC2 and XPB/ERCC3 during NER, retaining DNA near the XPB/ERCC3 active site, and stabilizing the complex in a different conformation than in transcribing TFIIH (PubMed:31253769). {ECO:0000269|PubMed:19197159, ECO:0000269|PubMed:31253769}. |
| P29374 | ARID4A | S427 | ochoa | AT-rich interactive domain-containing protein 4A (ARID domain-containing protein 4A) (Retinoblastoma-binding protein 1) (RBBP-1) | DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen receptor) (By similarity). May function as part of an mSin3A repressor complex (PubMed:14581478). Has no intrinsic transcriptional activity (By similarity). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4B (By similarity). Involved in spermatogenesis, together with ARID4B, where it acts as a transcriptional coactivator for AR and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier (By similarity). Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). {ECO:0000250|UniProtKB:F8VPQ2, ECO:0000269|PubMed:14581478}. |
| P29374 | ARID4A | S864 | ochoa|psp | AT-rich interactive domain-containing protein 4A (ARID domain-containing protein 4A) (Retinoblastoma-binding protein 1) (RBBP-1) | DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen receptor) (By similarity). May function as part of an mSin3A repressor complex (PubMed:14581478). Has no intrinsic transcriptional activity (By similarity). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4B (By similarity). Involved in spermatogenesis, together with ARID4B, where it acts as a transcriptional coactivator for AR and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier (By similarity). Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). {ECO:0000250|UniProtKB:F8VPQ2, ECO:0000269|PubMed:14581478}. |
| P29558 | RBMS1 | S213 | ochoa | RNA-binding motif, single-stranded-interacting protein 1 (Single-stranded DNA-binding protein MSSP-1) (Suppressor of CDC2 with RNA-binding motif 2) | Single-stranded DNA binding protein that interacts with the region upstream of the MYC gene. Binds specifically to the DNA sequence motif 5'-[AT]CT[AT][AT]T-3'. Probably has a role in DNA replication. |
| P29590 | PML | S493 | ochoa | Protein PML (E3 SUMO-protein ligase PML) (EC 2.3.2.-) (Promyelocytic leukemia protein) (RING finger protein 71) (RING-type E3 SUMO transferase PML) (Tripartite motif-containing protein 19) (TRIM19) | Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Inhibits EIF4E-mediated mRNA nuclear export by reducing EIF4E affinity for the 5' 7-methylguanosine (m7G) cap of target mRNAs (PubMed:11500381, PubMed:11575918, PubMed:18391071). Isoform PML-4 has a multifaceted role in the regulation of apoptosis and growth suppression: activates RB1 and inhibits AKT1 via interactions with PP1 and PP2A phosphatases respectively, negatively affects the PI3K pathway by inhibiting MTOR and activating PTEN, and positively regulates p53/TP53 by acting at different levels (by promoting its acetylation and phosphorylation and by inhibiting its MDM2-dependent degradation). Isoform PML-4 also: acts as a transcriptional repressor of TBX2 during cellular senescence and the repression is dependent on a functional RBL2/E2F4 repressor complex, regulates double-strand break repair in gamma-irradiation-induced DNA damage responses via its interaction with WRN, acts as a negative regulator of telomerase by interacting with TERT, and regulates PER2 nuclear localization and circadian function. Isoform PML-6 inhibits specifically the activity of the tetrameric form of PKM. The nuclear isoforms (isoform PML-1, isoform PML-2, isoform PML-3, isoform PML-4 and isoform PML-5) in concert with SATB1 are involved in local chromatin-loop remodeling and gene expression regulation at the MHC-I locus. Isoform PML-2 is required for efficient IFN-gamma induced MHC II gene transcription via regulation of CIITA. Cytoplasmic PML is involved in the regulation of the TGF-beta signaling pathway. PML also regulates transcription activity of ELF4 and can act as an important mediator for TNF-alpha- and IFN-alpha-mediated inhibition of endothelial cell network formation and migration. {ECO:0000269|PubMed:11500381, ECO:0000269|PubMed:11575918, ECO:0000269|PubMed:18391071}.; FUNCTION: Exhibits antiviral activity against both DNA and RNA viruses. The antiviral activity can involve one or several isoform(s) and can be enhanced by the permanent PML-NB-associated protein DAXX or by the recruitment of p53/TP53 within these structures. Isoform PML-4 restricts varicella zoster virus (VZV) via sequestration of virion capsids in PML-NBs thereby preventing their nuclear egress and inhibiting formation of infectious virus particles. The sumoylated isoform PML-4 restricts rabies virus by inhibiting viral mRNA and protein synthesis. The cytoplasmic isoform PML-14 can restrict herpes simplex virus-1 (HHV-1) replication by sequestering the viral E3 ubiquitin-protein ligase ICP0 in the cytoplasm. Isoform PML-6 shows restriction activity towards human cytomegalovirus (HHV-5) and influenza A virus strains PR8(H1N1) and ST364(H3N2). Sumoylated isoform PML-4 and isoform PML-12 show antiviral activity against encephalomyocarditis virus (EMCV) by promoting nuclear sequestration of viral polymerase (P3D-POL) within PML NBs. Isoform PML-3 exhibits antiviral activity against poliovirus by inducing apoptosis in infected cells through the recruitment and the activation of p53/TP53 in the PML-NBs. Isoform PML-3 represses human foamy virus (HFV) transcription by complexing the HFV transactivator, bel1/tas, preventing its binding to viral DNA. PML may positively regulate infectious hepatitis C viral (HCV) production and isoform PML-2 may enhance adenovirus transcription. Functions as an E3 SUMO-protein ligase that sumoylates (HHV-5) immediate early protein IE1, thereby participating in the antiviral response (PubMed:20972456, PubMed:28250117). Isoforms PML-3 and PML-6 display the highest levels of sumoylation activity (PubMed:20972456, PubMed:28250117). {ECO:0000269|PubMed:20972456, ECO:0000269|PubMed:28250117}. |
| P30414 | NKTR | S575 | ochoa | NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Component of a putative tumor-recognition complex involved in the function of NK cells (PubMed:8421688). {ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:8421688}. |
| P30530 | AXL | T508 | ochoa | Tyrosine-protein kinase receptor UFO (EC 2.7.10.1) (AXL oncogene) | Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, AXL binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. {ECO:0000269|PubMed:10403904, ECO:0000269|PubMed:11484958, ECO:0000269|PubMed:12364394, ECO:0000269|PubMed:12490074, ECO:0000269|PubMed:15507525, ECO:0000269|PubMed:15733062, ECO:0000269|PubMed:1656220, ECO:0000269|PubMed:18840707}.; FUNCTION: (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. {ECO:0000269|PubMed:17005688, ECO:0000269|PubMed:21501828, ECO:0000269|PubMed:22156524, ECO:0000269|PubMed:25277499}.; FUNCTION: (Microbial infection) Acts as a receptor for Ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. {ECO:0000269|PubMed:22673088}.; FUNCTION: (Microbial infection) Promotes Zika virus entry in glial cells, Sertoli cells and astrocytes (PubMed:28076778, PubMed:29379210, PubMed:31311882). Additionally, Zika virus potentiates AXL kinase activity to antagonize type I interferon signaling and thereby promotes infection (PubMed:28076778). Interferon signaling inhibition occurs via an SOCS1-dependent mechanism (PubMed:29379210). {ECO:0000269|PubMed:28076778, ECO:0000269|PubMed:29379210, ECO:0000269|PubMed:31311882}. |
| P31629 | HIVEP2 | S1447 | ochoa | Transcription factor HIVEP2 (Human immunodeficiency virus type I enhancer-binding protein 2) (HIV-EP2) (MHC-binding protein 2) (MBP-2) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation. |
| P33981 | TTK | S321 | ochoa|psp | Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT) | Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (PubMed:18243099, PubMed:28441529, PubMed:29162720). Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint (PubMed:18243099, PubMed:29162720). Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore (PubMed:18243099). Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments (PubMed:28441529). Phosphorylates KNL1, KNTC1 and autophosphorylates (PubMed:28441529). Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment (PubMed:30785839). {ECO:0000269|PubMed:18243099, ECO:0000269|PubMed:28441529, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:30785839}. |
| P40227 | CCT6A | S205 | ochoa | T-complex protein 1 subunit zeta (TCP-1-zeta) (EC 3.6.1.-) (Acute morphine dependence-related protein 2) (CCT-zeta-1) (Chaperonin containing T-complex polypeptide 1 subunit 6A) (HTR3) (Tcp20) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). {ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P40763 | STAT3 | S691 | ochoa | Signal transducer and activator of transcription 3 (Acute-phase response factor) | Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (PubMed:10688651, PubMed:12359225, PubMed:12873986, PubMed:15194700, PubMed:15653507, PubMed:16285960, PubMed:17344214, PubMed:18242580, PubMed:18782771, PubMed:22306293, PubMed:23084476, PubMed:28262505, PubMed:32929201, PubMed:38404237). Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:15653507, PubMed:16285960, PubMed:17344214, PubMed:18782771, PubMed:28262505, PubMed:32929201). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:12873986). Upon activation of IL6ST/gp130 signaling by interleukin-6 (IL6), binds to the IL6-responsive elements identified in the promoters of various acute-phase protein genes (PubMed:12359225). Activated by IL31 through IL31RA (PubMed:15194700). Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): acetylation promotes its transcription activity and cell differentiation while deacetylation and oxidation of lysine residues by LOXL3 inhibits differentiation (PubMed:28065600, PubMed:28262505). Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (PubMed:17344214). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (PubMed:23084476). Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion (By similarity). Following JAK/STAT signaling activation and as part of a complex with NFATC3 and NFATC4, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). {ECO:0000250|UniProtKB:P42227, ECO:0000269|PubMed:10688651, ECO:0000269|PubMed:12359225, ECO:0000269|PubMed:12873986, ECO:0000269|PubMed:15194700, ECO:0000269|PubMed:15653507, ECO:0000269|PubMed:16285960, ECO:0000269|PubMed:17344214, ECO:0000269|PubMed:18242580, ECO:0000269|PubMed:18782771, ECO:0000269|PubMed:22306293, ECO:0000269|PubMed:23084476, ECO:0000269|PubMed:28065600, ECO:0000269|PubMed:28262505, ECO:0000269|PubMed:32929201, ECO:0000269|PubMed:38404237}. |
| P40926 | MDH2 | S280 | ochoa | Malate dehydrogenase, mitochondrial (EC 1.1.1.37) | None |
| P46100 | ATRX | S703 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P46100 | ATRX | S788 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P49321 | NASP | S704 | ochoa | Nuclear autoantigenic sperm protein (NASP) | Component of the histone chaperone network (PubMed:22195965). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:22195965). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000250|UniProtKB:Q99MD9, ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 1]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 2]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}. |
| P49802 | RGS7 | S434 | psp | Regulator of G-protein signaling 7 (RGS7) | GTPase activator component of the RGS7-GNB5 complex that regulates G protein-coupled receptor signaling cascades (PubMed:10521509, PubMed:10862767, PubMed:31189666). The RGS7-GNB5 complex acts as an inhibitor signal transduction by promoting the GTPase activity of G protein alpha subunits, such as GNAO1, thereby driving them into their inactive GDP-bound form (PubMed:10521509, PubMed:10862767). May play a role in synaptic vesicle exocytosis (Probable) (PubMed:12659861). Glycine-dependent regulation of the RGS7-GNB5 complex by GPR158 affects mood and cognition via its ability to regulate neuronal excitability in L2/L3 pyramidal neurons of the prefrontal cortex (By similarity). Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling (PubMed:15897264). {ECO:0000250|UniProtKB:O54829, ECO:0000269|PubMed:10521509, ECO:0000269|PubMed:10862767, ECO:0000269|PubMed:15897264, ECO:0000269|PubMed:31189666, ECO:0000305|PubMed:12659861}. |
| P51810 | GPR143 | S331 | ochoa | G-protein coupled receptor 143 (Ocular albinism type 1 protein) | Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand-dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Also plays a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport. {ECO:0000269|PubMed:10471510, ECO:0000269|PubMed:16524428, ECO:0000269|PubMed:18697795, ECO:0000269|PubMed:18828673, ECO:0000269|PubMed:19717472}. |
| P52292 | KPNA2 | S24 | ochoa | Importin subunit alpha-1 (Karyopherin subunit alpha-2) (RAG cohort protein 1) (SRP1-alpha) | Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1 (PubMed:28991411, PubMed:32130408, PubMed:7604027, PubMed:7754385). Binds specifically and directly to substrates containing either a simple or bipartite NLS motif (PubMed:28991411, PubMed:32130408, PubMed:7604027, PubMed:7754385). Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:7604027, PubMed:7754385). At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediator of PR-DUB complex component BAP1 nuclear import; acts redundantly with KPNA1 and Transportin-1/TNPO1 (PubMed:35446349). {ECO:0000269|PubMed:28991411, ECO:0000269|PubMed:32130408, ECO:0000269|PubMed:35446349, ECO:0000269|PubMed:7604027, ECO:0000269|PubMed:7754385}. |
| P55072 | VCP | S702 | ochoa | Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP) | Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Mediates the endoplasmic reticulum-associated degradation of CHRNA3 in cortical neurons as part of the STUB1-VCP-UBXN2A complex (PubMed:26265139). Involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). Involved in clearance process by mediating G3BP1 extraction from stress granules (PubMed:29804830, PubMed:34739333). Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites (PubMed:22020440, PubMed:22120668). Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage (PubMed:23042605, PubMed:23042607). Together with SPRTN metalloprotease, involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis (PubMed:32152270). Involved in interstrand cross-link repair in response to replication stress by mediating unloading of the ubiquitinated CMG helicase complex (By similarity). Mediates extraction of PARP1 trapped to chromatin: recognizes and binds ubiquitinated PARP1 and promotes its removal (PubMed:35013556). Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation (PubMed:16186510, PubMed:21118995). Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy (PubMed:20104022, PubMed:27753622). Acts as a negative regulator of type I interferon production by interacting with RIGI: interaction takes place when RIGI is ubiquitinated via 'Lys-63'-linked ubiquitin on its CARD domains, leading to recruit RNF125 and promote ubiquitination and degradation of RIGI (PubMed:26471729). May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation (PubMed:21822278). May more particularly play a role in caveolins sorting in cells (PubMed:21822278, PubMed:23335559). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:P23787, ECO:0000269|PubMed:15456787, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:16186510, ECO:0000269|PubMed:20104022, ECO:0000269|PubMed:21118995, ECO:0000269|PubMed:21822278, ECO:0000269|PubMed:22020440, ECO:0000269|PubMed:22120668, ECO:0000269|PubMed:22607976, ECO:0000269|PubMed:23042605, ECO:0000269|PubMed:23042607, ECO:0000269|PubMed:23335559, ECO:0000269|PubMed:26265139, ECO:0000269|PubMed:26471729, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:27753622, ECO:0000269|PubMed:29804830, ECO:0000269|PubMed:32152270, ECO:0000269|PubMed:34739333, ECO:0000269|PubMed:35013556}. |
| P55201 | BRPF1 | S1187 | ochoa | Peregrin (Bromodomain and PHD finger-containing protein 1) (Protein Br140) | Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:24065767, PubMed:27939640). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac) (PubMed:24065767). Some HAT complexes preferentially mediate histone H3 'Lys-23' (H3K23ac) acetylation (PubMed:27939640). Positively regulates the transcription of RUNX1 and RUNX2 (PubMed:18794358). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:18794358, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:27939640}. |
| P62330 | ARF6 | S38 | ochoa | ADP-ribosylation factor 6 (EC 3.6.5.2) | GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling (PubMed:11266366, PubMed:16737952, PubMed:18400762, PubMed:21170023, PubMed:32103017, PubMed:7589240). GTP-bound form plays an important role in the transport of multiple palmitoylated proteins form the Golgi to the plasma membrane (PubMed:37461827). Required for normal completion of mitotic cytokinesis (By similarity). Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers (By similarity). Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension (PubMed:14978216). Potentiates the neurite outgrowth in primary neurons by interacting with the molecular adapter APBB1 (PubMed:36250347). Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization (PubMed:36017701). Regulates surface levels of adherens junction proteins such as CDH1 (By similarity). Required for NTRK1 sorting to the recycling pathway from early endosomes (By similarity). {ECO:0000250|UniProtKB:P62331, ECO:0000250|UniProtKB:P62332, ECO:0000269|PubMed:11266366, ECO:0000269|PubMed:14978216, ECO:0000269|PubMed:16099990, ECO:0000269|PubMed:16737952, ECO:0000269|PubMed:18400762, ECO:0000269|PubMed:21170023, ECO:0000269|PubMed:32103017, ECO:0000269|PubMed:36017701, ECO:0000269|PubMed:36250347, ECO:0000269|PubMed:37461827, ECO:0000269|PubMed:7589240}.; FUNCTION: (Microbial infection) Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. {ECO:0000269|PubMed:16099990}.; FUNCTION: (Microbial infection) Plays a key role in the endocytosis of enterovirus 71 and thus viral entry into brain microvascular endothelial cells. {ECO:0000269|PubMed:37417384}. |
| P63165 | SUMO1 | S31 | ochoa | Small ubiquitin-related modifier 1 (SUMO-1) (GAP-modifying protein 1) (GMP1) (SMT3 homolog 3) (Sentrin) (Ubiquitin-homology domain protein PIC1) (Ubiquitin-like protein SMT3C) (Smt3C) (Ubiquitin-like protein UBL1) | Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1 (PubMed:19223394). Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3 (PubMed:24651376). {ECO:0000269|PubMed:18408734, ECO:0000269|PubMed:18538659, ECO:0000269|PubMed:19223394, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:24651376, ECO:0000269|PubMed:9019411, ECO:0000269|PubMed:9162015}. |
| P78527 | PRKDC | S3432 | ochoa | DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) | Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250|UniProtKB:P97313, ECO:0000269|PubMed:10026262, ECO:0000269|PubMed:10467406, ECO:0000269|PubMed:11889123, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12509254, ECO:0000269|PubMed:12649176, ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:14612514, ECO:0000269|PubMed:14627815, ECO:0000269|PubMed:14704337, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:15262962, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:1597196, ECO:0000269|PubMed:16046194, ECO:0000269|PubMed:16397295, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:2247066, ECO:0000269|PubMed:2507541, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30247612, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33854234, ECO:0000269|PubMed:34352203, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:8407951, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9362500, ECO:0000269|PubMed:9363941, ECO:0000269|PubMed:9679063}. |
| P83731 | RPL24 | S64 | ochoa | Large ribosomal subunit protein eL24 (60S ribosomal protein L24) (60S ribosomal protein L30) | Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| Q00577 | PURA | S256 | ochoa | Transcriptional activator protein Pur-alpha (Purine-rich single-stranded DNA-binding protein alpha) | This is a probable transcription activator that specifically binds the purine-rich single strand of the PUR element located upstream of the MYC gene (PubMed:1448097, PubMed:20976240). May play a role in the initiation of DNA replication and in recombination. {ECO:0000269|PubMed:1448097, ECO:0000269|PubMed:20976240}. |
| Q00688 | FKBP3 | S100 | ochoa | Peptidyl-prolyl cis-trans isomerase FKBP3 (PPIase FKBP3) (EC 5.2.1.8) (25 kDa FK506-binding protein) (25 kDa FKBP) (FKBP-25) (FK506-binding protein 3) (FKBP-3) (Immunophilin FKBP25) (Rapamycin-selective 25 kDa immunophilin) (Rotamase) | FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins. |
| Q01995 | TAGLN | S166 | ochoa | Transgelin (22 kDa actin-binding protein) (Protein WS3-10) (Smooth muscle protein 22-alpha) (SM22-alpha) | Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence. {ECO:0000250}. |
| Q02543 | RPL18A | S58 | ochoa | Large ribosomal subunit protein eL20 (60S ribosomal protein L18a) | Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| Q03164 | KMT2A | S2315 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q06787 | FMR1 | S599 | ochoa | Fragile X messenger ribonucleoprotein 1 (Fragile X messenger ribonucleoprotein) (FMRP) (Protein FMR-1) | Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of target mRNAs (PubMed:12417522, PubMed:16631377, PubMed:18653529, PubMed:19166269, PubMed:23235829, PubMed:25464849). Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (PubMed:12417522, PubMed:30765518, PubMed:31439799). Plays a role in the alternative splicing of its own mRNA (PubMed:18653529). Stabilizes the scaffolding postsynaptic density protein DLG4/PSD-95 and the myelin basic protein (MBP) mRNAs in hippocampal neurons and glial cells, respectively; this stabilization is further increased in response to metabotropic glutamate receptor (mGluR) stimulation (By similarity). Plays a role in selective delivery of a subset of dendritic mRNAs to synaptic sites in response to mGluR activation in a kinesin-dependent manner (By similarity). Undergoes liquid-liquid phase separation following phosphorylation and interaction with CAPRIN1, promoting formation of cytoplasmic ribonucleoprotein granules that concentrate mRNAs with factors that inhibit translation and mediate deadenylation of target mRNAs (PubMed:31439799). Acts as a repressor of mRNA translation in synaptic regions by mediating formation of neuronal ribonucleoprotein granules and promoting recruitmtent of EIF4EBP2 (PubMed:30765518). Plays a role as a repressor of mRNA translation during the transport of dendritic mRNAs to postsynaptic dendritic spines (PubMed:11157796, PubMed:11532944, PubMed:12594214, PubMed:23235829). Component of the CYFIP1-EIF4E-FMR1 complex which blocks cap-dependent mRNA translation initiation (By similarity). Represses mRNA translation by stalling ribosomal translocation during elongation (By similarity). Reports are contradictory with regards to its ability to mediate translation inhibition of MBP mRNA in oligodendrocytes (PubMed:23891804). Also involved in the recruitment of the RNA helicase MOV10 to a subset of mRNAs and hence regulates microRNA (miRNA)-mediated translational repression by AGO2 (PubMed:14703574, PubMed:17057366, PubMed:25464849). Facilitates the assembly of miRNAs on specific target mRNAs (PubMed:17057366). Also plays a role as an activator of mRNA translation of a subset of dendritic mRNAs at synapses (PubMed:19097999, PubMed:19166269). In response to mGluR stimulation, FMR1-target mRNAs are rapidly derepressed, allowing for local translation at synapses (By similarity). Binds to a large subset of dendritic mRNAs that encode a myriad of proteins involved in pre- and postsynaptic functions (PubMed:11157796, PubMed:11719189, PubMed:12594214, PubMed:17417632, PubMed:23235829, PubMed:24448548, PubMed:7692601). Binds to 5'-ACU[GU]-3' and/or 5'-[AU]GGA-3' RNA consensus sequences within mRNA targets, mainly at coding sequence (CDS) and 3'-untranslated region (UTR) and less frequently at 5'-UTR (PubMed:23235829). Binds to intramolecular G-quadruplex structures in the 5'- or 3'-UTRs of mRNA targets (PubMed:11719189, PubMed:18579868, PubMed:25464849, PubMed:25692235). Binds to G-quadruplex structures in the 3'-UTR of its own mRNA (PubMed:11532944, PubMed:12594214, PubMed:15282548, PubMed:18653529, PubMed:7692601). Also binds to RNA ligands harboring a kissing complex (kc) structure; this binding may mediate the association of FMR1 with polyribosomes (PubMed:15805463). Binds mRNAs containing U-rich target sequences (PubMed:12927206). Binds to a triple stem-loop RNA structure, called Sod1 stem loop interacting with FMRP (SoSLIP), in the 5'-UTR region of superoxide dismutase SOD1 mRNA (PubMed:19166269). Binds to the dendritic, small non-coding brain cytoplasmic RNA 1 (BC1); which may increase the association of the CYFIP1-EIF4E-FMR1 complex to FMR1 target mRNAs at synapses (By similarity). Plays a role in mRNA nuclear export (PubMed:31753916). Specifically recognizes and binds a subset of N6-methyladenosine (m6A)-containing mRNAs, promoting their nuclear export in a XPO1/CRM1-dependent manner (PubMed:31753916). Together with export factor NXF2, is involved in the regulation of the NXF1 mRNA stability in neurons (By similarity). Associates with export factor NXF1 mRNA-containing ribonucleoprotein particles (mRNPs) in a NXF2-dependent manner (By similarity). Binds to a subset of miRNAs in the brain (PubMed:14703574, PubMed:17057366). May associate with nascent transcripts in a nuclear protein NXF1-dependent manner (PubMed:18936162). In vitro, binds to RNA homomer; preferentially on poly(G) and to a lesser extent on poly(U), but not on poly(A) or poly(C) (PubMed:12950170, PubMed:15381419, PubMed:7688265, PubMed:7781595, PubMed:8156595). Moreover, plays a role in the modulation of the sodium-activated potassium channel KCNT1 gating activity (PubMed:20512134). Negatively regulates the voltage-dependent calcium channel current density in soma and presynaptic terminals of dorsal root ganglion (DRG) neurons, and hence regulates synaptic vesicle exocytosis (By similarity). Modulates the voltage-dependent calcium channel CACNA1B expression at the plasma membrane by targeting the channels for proteasomal degradation (By similarity). Plays a role in regulation of MAP1B-dependent microtubule dynamics during neuronal development (By similarity). Has been shown to play a translation-independent role in the modulation of presynaptic action potential (AP) duration and neurotransmitter release via large-conductance calcium-activated potassium (BK) channels in hippocampal and cortical excitatory neurons (PubMed:25561520). May be involved in the control of DNA damage response (DDR) mechanisms through the regulation of ATR-dependent signaling pathways such as histone H2AX/H2A.x and BRCA1 phosphorylations (PubMed:24813610). Forms a cytoplasmic messenger ribonucleoprotein (mRNP) network by packaging long mRNAs, serving as a scaffold that recruits proteins and signaling molecules. This network facilitates signaling reactions by maintaining proximity between kinases and substrates (PubMed:39106863). {ECO:0000250|UniProtKB:P35922, ECO:0000250|UniProtKB:Q80WE1, ECO:0000269|PubMed:11157796, ECO:0000269|PubMed:11532944, ECO:0000269|PubMed:11719189, ECO:0000269|PubMed:12417522, ECO:0000269|PubMed:12594214, ECO:0000269|PubMed:12927206, ECO:0000269|PubMed:12950170, ECO:0000269|PubMed:14703574, ECO:0000269|PubMed:15282548, ECO:0000269|PubMed:15381419, ECO:0000269|PubMed:15805463, ECO:0000269|PubMed:16631377, ECO:0000269|PubMed:17057366, ECO:0000269|PubMed:17417632, ECO:0000269|PubMed:18579868, ECO:0000269|PubMed:18653529, ECO:0000269|PubMed:18936162, ECO:0000269|PubMed:19097999, ECO:0000269|PubMed:19166269, ECO:0000269|PubMed:20512134, ECO:0000269|PubMed:23235829, ECO:0000269|PubMed:23891804, ECO:0000269|PubMed:24448548, ECO:0000269|PubMed:24813610, ECO:0000269|PubMed:25464849, ECO:0000269|PubMed:25561520, ECO:0000269|PubMed:25692235, ECO:0000269|PubMed:30765518, ECO:0000269|PubMed:31439799, ECO:0000269|PubMed:31753916, ECO:0000269|PubMed:39106863, ECO:0000269|PubMed:7688265, ECO:0000269|PubMed:7692601, ECO:0000269|PubMed:7781595, ECO:0000269|PubMed:8156595}.; FUNCTION: [Isoform 10]: Binds to RNA homomer; preferentially on poly(G) and to a lesser extent on poly(U), but not on poly(A) or poly(C) (PubMed:24204304). May bind to RNA in Cajal bodies (PubMed:24204304). {ECO:0000269|PubMed:24204304}.; FUNCTION: [Isoform 6]: Binds to RNA homomer; preferentially on poly(G) and to a lesser extent on poly(U), but not on poly(A) or poly(C) (PubMed:24204304). May bind to RNA in Cajal bodies (PubMed:24204304). {ECO:0000269|PubMed:24204304}.; FUNCTION: (Microbial infection) Acts as a positive regulator of influenza A virus (IAV) replication. Required for the assembly and nuclear export of the viral ribonucleoprotein (vRNP) components. {ECO:0000269|PubMed:24514761}. |
| Q12955 | ANK3 | S2445 | ochoa | Ankyrin-3 (ANK-3) (Ankyrin-G) | Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (PubMed:7836469). In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). {ECO:0000250|UniProtKB:G5E8K5, ECO:0000250|UniProtKB:O70511, ECO:0000269|PubMed:23903368, ECO:0000269|PubMed:7836469}.; FUNCTION: [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. {ECO:0000305|PubMed:17974005}. |
| Q13017 | ARHGAP5 | S1195 | ochoa | Rho GTPase-activating protein 5 (Rho-type GTPase-activating protein 5) (p190-B) | GTPase-activating protein for Rho family members (PubMed:8537347). {ECO:0000269|PubMed:8537347}. |
| Q13546 | RIPK1 | S610 | ochoa | Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1) | Serine-threonine kinase which is a key regulator of TNF-mediated apoptosis, necroptosis and inflammatory pathways (PubMed:17703191, PubMed:24144979, PubMed:31827280, PubMed:31827281, PubMed:32657447, PubMed:35831301). Exhibits kinase activity-dependent functions that regulate cell death and kinase-independent scaffold functions regulating inflammatory signaling and cell survival (PubMed:11101870, PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Has kinase-independent scaffold functions: upon binding of TNF to TNFR1, RIPK1 is recruited to the TNF-R1 signaling complex (TNF-RSC also known as complex I) where it acts as a scaffold protein promoting cell survival, in part, by activating the canonical NF-kappa-B pathway (By similarity). Kinase activity is essential to regulate necroptosis and apoptosis, two parallel forms of cell death: upon activation of its protein kinase activity, regulates assembly of two death-inducing complexes, namely complex IIa (RIPK1-FADD-CASP8), which drives apoptosis, and the complex IIb (RIPK1-RIPK3-MLKL), which drives necroptosis (By similarity). RIPK1 is required to limit CASP8-dependent TNFR1-induced apoptosis (By similarity). In normal conditions, RIPK1 acts as an inhibitor of RIPK3-dependent necroptosis, a process mediated by RIPK3 component of complex IIb, which catalyzes phosphorylation of MLKL upon induction by ZBP1 (PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Inhibits RIPK3-mediated necroptosis via FADD-mediated recruitment of CASP8, which cleaves RIPK1 and limits TNF-induced necroptosis (PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Required to inhibit apoptosis and necroptosis during embryonic development: acts by preventing the interaction of TRADD with FADD thereby limiting aberrant activation of CASP8 (By similarity). In addition to apoptosis and necroptosis, also involved in inflammatory response by promoting transcriptional production of pro-inflammatory cytokines, such as interleukin-6 (IL6) (PubMed:31827280, PubMed:31827281). Phosphorylates RIPK3: RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation (PubMed:19524513). Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade (PubMed:15310755, PubMed:17389591). Required for ZBP1-induced NF-kappa-B activation in response to DNA damage (By similarity). {ECO:0000250|UniProtKB:Q60855, ECO:0000269|PubMed:11101870, ECO:0000269|PubMed:15310755, ECO:0000269|PubMed:17389591, ECO:0000269|PubMed:17703191, ECO:0000269|PubMed:19524512, ECO:0000269|PubMed:19524513, ECO:0000269|PubMed:24144979, ECO:0000269|PubMed:29440439, ECO:0000269|PubMed:30988283, ECO:0000269|PubMed:31827280, ECO:0000269|PubMed:31827281, ECO:0000269|PubMed:32657447, ECO:0000269|PubMed:35831301}. |
| Q14151 | SAFB2 | S507 | ochoa | Scaffold attachment factor B2 (SAF-B2) | Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation. |
| Q14203 | DCTN1 | S541 | ochoa | Dynactin subunit 1 (150 kDa dynein-associated polypeptide) (DAP-150) (DP-150) (p135) (p150-glued) | Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule (PubMed:25185702). Can regulate microtubule stability by promoting microtubule formation, nucleation and polymerization and by inhibiting microtubule catastrophe in neurons. Inhibits microtubule catastrophe by binding both to microtubules and to tubulin, leading to enhanced microtubule stability along the axon (PubMed:23874158). Plays a role in metaphase spindle orientation (PubMed:22327364). Plays a role in centriole cohesion and subdistal appendage organization and function. Its recruitment to the centriole in a KIF3A-dependent manner is essential for the maintenance of centriole cohesion and the formation of subdistal appendage. Also required for microtubule anchoring at the mother centriole (PubMed:23386061). Plays a role in primary cilia formation (PubMed:25774020). {ECO:0000250|UniProtKB:A0A287B8J2, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23386061, ECO:0000269|PubMed:23874158, ECO:0000269|PubMed:25185702, ECO:0000269|PubMed:25774020}. |
| Q14644 | RASA3 | S809 | ochoa | Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) | Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) with high affinity. Might be a specific IP4 receptor. |
| Q14669 | TRIP12 | S310 | ochoa | E3 ubiquitin-protein ligase TRIP12 (EC 2.3.2.26) (E3 ubiquitin-protein ligase for Arf) (ULF) (HECT-type E3 ubiquitin transferase TRIP12) (Thyroid receptor-interacting protein 12) (TR-interacting protein 12) (TRIP-12) | E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair (PubMed:19028681, PubMed:22884692). Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins (PubMed:19028681). Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress (PubMed:20208519). In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation (PubMed:20208519). Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A (PubMed:20208519). Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation (PubMed:18627766). Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins (PubMed:20829358). Mediates ubiquitination of ASXL1: following binding to N(6)-methyladenosine methylated DNA, ASXL1 is ubiquitinated by TRIP12, leading to its degradation and subsequent inactivation of the PR-DUB complex (PubMed:30982744). {ECO:0000269|PubMed:18627766, ECO:0000269|PubMed:19028681, ECO:0000269|PubMed:20208519, ECO:0000269|PubMed:20829358, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:30982744}. |
| Q14676 | MDC1 | S1086 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14692 | BMS1 | S49 | ochoa | Ribosome biogenesis protein BMS1 homolog (EC 3.6.5.-) (Ribosome assembly protein BMS1 homolog) | GTPase required for the synthesis of 40S ribosomal subunits and for processing of pre-ribosomal RNA (pre-rRNA) at sites A0, A1, and A2. Controls access of pre-rRNA intermediates to RCL1 during ribosome biogenesis by binding RCL1 in a GTP-dependent manner, and delivering it to pre-ribosomes. GTP-binding and/or GTP hydrolysis may induce conformational rearrangements within the BMS1-RCL1 complex allowing the interaction of RCL1 with its RNA substrate. Required for RCL1 import into the nucleus. {ECO:0000250|UniProtKB:Q08965}. |
| Q15052 | ARHGEF6 | Y644 | ochoa | Rho guanine nucleotide exchange factor 6 (Alpha-Pix) (COOL-2) (PAK-interacting exchange factor alpha) (Rac/Cdc42 guanine nucleotide exchange factor 6) | Acts as a RAC1 guanine nucleotide exchange factor (GEF). |
| Q15111 | PLCL1 | S97 | ochoa | Inactive phospholipase C-like protein 1 (PLC-L1) (Phospholipase C-deleted in lung carcinoma) (Phospholipase C-related but catalytically inactive protein) (PRIP) | Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor (By similarity). Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as an inhibitor of PPP1C. {ECO:0000250, ECO:0000269|PubMed:17254016}. |
| Q15121 | PEA15 | S90 | ochoa | Astrocytic phosphoprotein PEA-15 (15 kDa phosphoprotein enriched in astrocytes) (Phosphoprotein enriched in diabetes) (PED) | Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface. {ECO:0000250, ECO:0000269|PubMed:10442631, ECO:0000269|PubMed:9670003}. |
| Q15233 | NONO | S209 | ochoa | Non-POU domain-containing octamer-binding protein (NonO protein) (54 kDa nuclear RNA- and DNA-binding protein) (p54(nrb)) (p54nrb) (55 kDa nuclear protein) (NMT55) (DNA-binding p52/p100 complex, 52 kDa subunit) | DNA- and RNA binding protein, involved in several nuclear processes (PubMed:11525732, PubMed:12403470, PubMed:26571461). Binds the conventional octamer sequence in double-stranded DNA (PubMed:11525732, PubMed:12403470, PubMed:26571461). Also binds single-stranded DNA and RNA at a site independent of the duplex site (PubMed:11525732, PubMed:12403470, PubMed:26571461). Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ (PubMed:11525732, PubMed:12403470, PubMed:26571461). Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b (PubMed:12403470). Together with PSPC1, required for the formation of nuclear paraspeckles (PubMed:22416126). The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs (PubMed:11525732). The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1 (PubMed:10858305). The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends (PubMed:15590677). In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex (PubMed:15590677). NONO is involved in transcriptional regulation. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity (PubMed:11897684). NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription (By similarity). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (By similarity). Important for the functional organization of GABAergic synapses (By similarity). Plays a specific and important role in the regulation of synaptic RNAs and GPHN/gephyrin scaffold structure, through the regulation of GABRA2 transcript (By similarity). Plays a key role during neuronal differentiation by recruiting TET1 to genomic loci and thereby regulating 5-hydroxymethylcytosine levels (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728, PubMed:30270045). Promotes activation of the cGAS-STING pathway in response to HIV-2 infection: acts by interacting with HIV-2 Capsid protein p24, thereby promoting detection of viral DNA by CGAS, leading to CGAS-mediated inmmune activation (PubMed:30270045). In contrast, the weak interaction with HIV-1 Capsid protein p24 does not allow activation of the cGAS-STING pathway (PubMed:30270045). {ECO:0000250|UniProtKB:Q99K48, ECO:0000269|PubMed:10858305, ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:11897684, ECO:0000269|PubMed:12403470, ECO:0000269|PubMed:15590677, ECO:0000269|PubMed:22416126, ECO:0000269|PubMed:26571461, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:30270045}. |
| Q15424 | SAFB | S582 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q15464 | SHB | S265 | ochoa | SH2 domain-containing adapter protein B | Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells. {ECO:0000269|PubMed:10828022, ECO:0000269|PubMed:10837138, ECO:0000269|PubMed:12084069, ECO:0000269|PubMed:12464388, ECO:0000269|PubMed:12520086, ECO:0000269|PubMed:15026417, ECO:0000269|PubMed:15919073, ECO:0000269|PubMed:8806685, ECO:0000269|PubMed:9484780, ECO:0000269|PubMed:9751119}. |
| Q27J81 | INF2 | S1229 | ochoa | Inverted formin-2 (HBEBP2-binding protein C) | Severs actin filaments and accelerates their polymerization and depolymerization. {ECO:0000250}. |
| Q5M9Q1 | NKAPL | S362 | ochoa | NKAP-like protein | Transcriptional repressor of Notch-mediated signaling. Required for spermatogenesis. {ECO:0000250|UniProtKB:Q5SZT7}. |
| Q5VT25 | CDC42BPA | S1003 | psp | Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha) | Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration (PubMed:15723050, PubMed:9092543, PubMed:9418861). Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates: PPP1R12A, LIMK1 and LIMK2 (PubMed:11340065, PubMed:11399775). May play a role in TFRC-mediated iron uptake (PubMed:20188707). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). Triggers the formation of an extrusion apical actin ring required for epithelial extrusion of apoptotic cells (PubMed:29162624). {ECO:0000250|UniProtKB:Q3UU96, ECO:0000269|PubMed:11340065, ECO:0000269|PubMed:11399775, ECO:0000269|PubMed:15723050, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:20188707, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:29162624, ECO:0000269|PubMed:9092543, ECO:0000269|PubMed:9418861}. |
| Q5VUA4 | ZNF318 | S264 | ochoa | Zinc finger protein 318 (Endocrine regulatory protein) | [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}. |
| Q5VUB5 | FAM171A1 | S422 | ochoa | Protein FAM171A1 (Astroprincin) (APCN) | Involved in the regulation of the cytoskeletal dynamics, plays a role in actin stress fiber formation. {ECO:0000269|PubMed:30312582}. |
| Q5VV41 | ARHGEF16 | S208 | ochoa | Rho guanine nucleotide exchange factor 16 (Ephexin-4) | Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6. {ECO:0000269|PubMed:20679435}. |
| Q6DN14 | MCTP1 | S403 | ochoa | Multiple C2 and transmembrane domain-containing protein 1 | Calcium sensor which is essential for the stabilization of normal baseline neurotransmitter release and for the induction and long-term maintenance of presynaptic homeostatic plasticity. {ECO:0000250|UniProtKB:A1ZBD6}. |
| Q6DT37 | CDC42BPG | S1514 | ochoa | Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42-binding protein kinase gamma) (DMPK-like gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (MRCK gamma) (MRCKG) (Myotonic dystrophy protein kinase-like gamma) (Myotonic dystrophy protein kinase-like alpha) | May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation (By similarity). {ECO:0000250|UniProtKB:Q5VT25, ECO:0000269|PubMed:15194684}. |
| Q6IQ55 | TTBK2 | S448 | ochoa | Tau-tubulin kinase 2 (EC 2.7.11.1) | Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro (PubMed:23141541). Phosphorylates MPHOSPH9 which promotes its ubiquitination and proteasomal degradation, loss of MPHOSPH9 facilitates the removal of the CP110-CEP97 complex (a negative regulator of ciliogenesis) from the mother centrioles, promoting the initiation of ciliogenesis (PubMed:30375385). Required for recruitment of CPLANE2 and INTU to the mother centriole (By similarity). {ECO:0000250|UniProtKB:Q3UVR3, ECO:0000269|PubMed:21548880, ECO:0000269|PubMed:23141541, ECO:0000269|PubMed:30375385}. |
| Q6ZSR9 | None | S157 | ochoa | Uncharacterized protein FLJ45252 | None |
| Q6ZUJ8 | PIK3AP1 | S562 | ochoa | Phosphoinositide 3-kinase adapter protein 1 (B-cell adapter for phosphoinositide 3-kinase) (B-cell phosphoinositide 3-kinase adapter protein 1) | Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL. {ECO:0000269|PubMed:15893754}. |
| Q6ZUJ8 | PIK3AP1 | S572 | ochoa | Phosphoinositide 3-kinase adapter protein 1 (B-cell adapter for phosphoinositide 3-kinase) (B-cell phosphoinositide 3-kinase adapter protein 1) | Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL. {ECO:0000269|PubMed:15893754}. |
| Q76FK4 | NOL8 | S663 | ochoa | Nucleolar protein 8 (Nucleolar protein Nop132) | Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells. {ECO:0000269|PubMed:14660641, ECO:0000269|PubMed:15132771, ECO:0000269|PubMed:16963496}. |
| Q7L4I2 | RSRC2 | S376 | ochoa | Arginine/serine-rich coiled-coil protein 2 | None |
| Q7Z2K8 | GPRIN1 | S382 | ochoa | G protein-regulated inducer of neurite outgrowth 1 (GRIN1) | May be involved in neurite outgrowth. {ECO:0000250}. |
| Q7Z7B0 | FILIP1 | S1082 | ochoa | Filamin-A-interacting protein 1 (FILIP) | By acting through a filamin-A/F-actin axis, it controls the start of neocortical cell migration from the ventricular zone. May be able to induce the degradation of filamin-A. {ECO:0000250|UniProtKB:Q8K4T4}. |
| Q7Z7L1 | SLFN11 | S142 | ochoa | Schlafen family member 11 (EC 3.1.-.-) | Inhibitor of DNA replication that promotes cell death in response to DNA damage (PubMed:22927417, PubMed:26658330, PubMed:29395061). Acts as a guardian of the genome by killing cells with defective replication (PubMed:29395061). Persistently blocks stressed replication forks by opening chromatin across replication initiation sites at stressed replication forks, possibly leading to unwind DNA ahead of the MCM helicase and block fork progression, ultimately leading to cell death (PubMed:29395061). Upon DNA damage, inhibits translation of ATR or ATM based on distinct codon usage without disrupting early DNA damage response signaling (PubMed:30374083). Antiviral restriction factor with manganese-dependent type II tRNA endoribonuclease (PubMed:36115853). A single tRNA molecule is bound and cleaved by the SLFN11 dimer (PubMed:36115853). Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner (PubMed:23000900). Impairs the replication of human cytomegalovirus (HCMV) and some Flaviviruses (PubMed:35105802, PubMed:36115853). Exploits the unique viral codon bias towards A/T nucleotides (PubMed:23000900). Also acts as an interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis (PubMed:23000900). {ECO:0000269|PubMed:22927417, ECO:0000269|PubMed:23000900, ECO:0000269|PubMed:26658330, ECO:0000269|PubMed:29395061, ECO:0000269|PubMed:30374083, ECO:0000269|PubMed:35105802, ECO:0000269|PubMed:36115853}. |
| Q86UP2 | KTN1 | S1084 | ochoa | Kinectin (CG-1 antigen) (Kinesin receptor) | Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin. |
| Q86V48 | LUZP1 | S908 | ochoa | Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin) | F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250|UniProtKB:Q8R4U7, ECO:0000269|PubMed:30990684, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:38009294, ECO:0000269|PubMed:38832964}. |
| Q8IVF5 | TIAM2 | S1569 | ochoa | Rho guanine nucleotide exchange factor TIAM2 (SIF and TIAM1-like exchange factor) (T-lymphoma invasion and metastasis-inducing protein 2) (TIAM-2) | Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane (By similarity). Activates specifically RAC1, but not CDC42 and RHOA. {ECO:0000250, ECO:0000269|PubMed:10512681}. |
| Q8IVL0 | NAV3 | S1117 | ochoa | Neuron navigator 3 (Pore membrane and/or filament-interacting-like protein 1) (Steerin-3) (Unc-53 homolog 3) (unc53H3) | Plays a role in cell migration (PubMed:21471154). May be involved in neuron regeneration. May regulate IL2 production by T-cells. {ECO:0000269|PubMed:16166283, ECO:0000269|PubMed:21471154}. |
| Q8IW00 | VSTM4 | S224 | ochoa | V-set and transmembrane domain-containing protein 4 [Cleaved into: Peptide Lv] | Peptide Lv enhances L-type voltage-gated calcium channel (L-VGCC) currents in retinal photoreceptors. {ECO:0000250|UniProtKB:T1NXB5}. |
| Q8IYD8 | FANCM | S1437 | ochoa | Fanconi anemia group M protein (Protein FACM) (EC 3.6.4.13) (ATP-dependent RNA helicase FANCM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog) | DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (PubMed:16116422). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:16116422, PubMed:19423727, PubMed:20347428, PubMed:20347429, PubMed:29231814). In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (PubMed:20347428, PubMed:20347429). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX (PubMed:20347429). In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates (PubMed:17289582). In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA (PubMed:16116434). {ECO:0000269|PubMed:16116422, ECO:0000269|PubMed:16116434, ECO:0000269|PubMed:17289582, ECO:0000269|PubMed:19423727, ECO:0000269|PubMed:20347428, ECO:0000269|PubMed:20347429, ECO:0000269|PubMed:29231814}. |
| Q8IYS0 | GRAMD1C | S531 | ochoa | Protein Aster-C (GRAM domain-containing protein 1C) | Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). {ECO:0000250|UniProtKB:Q8CI52}. |
| Q8N4C6 | NIN | S1931 | ochoa | Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein) | Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells (PubMed:15190203, PubMed:23386061). May also act as a centrosome maturation factor (PubMed:11956314). May play a role in microtubule nucleation, by recruiting the gamma-tubulin ring complex to the centrosome (PubMed:15190203). Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules (PubMed:15190203). Required for centriole organization and microtubule anchoring at the mother centriole (PubMed:23386061). {ECO:0000269|PubMed:11956314, ECO:0000269|PubMed:15190203, ECO:0000269|PubMed:23386061}. |
| Q8N5F7 | NKAP | S375 | ochoa | NF-kappa-B-activating protein | Acts as a transcriptional repressor (PubMed:14550261, PubMed:19409814, PubMed:31587868). Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development (PubMed:19409814). Also involved in the TNF and IL-1 induced NF-kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter. {ECO:0000269|PubMed:14550261, ECO:0000269|PubMed:19409814, ECO:0000269|PubMed:31587868}. |
| Q8N8Z6 | DCBLD1 | S488 | ochoa|psp | Discoidin, CUB and LCCL domain-containing protein 1 | None |
| Q8NB12 | SMYD1 | S298 | ochoa | Histone-lysine N-methyltransferase SMYD1 (EC 2.1.1.354) (SET and MYND domain-containing protein 1) | Methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. Acts as a transcriptional repressor. Essential for cardiomyocyte differentiation and cardiac morphogenesis. {ECO:0000250|UniProtKB:P97443}. |
| Q8NC51 | SERBP1 | S85 | ochoa | SERPINE1 mRNA-binding protein 1 (PAI1 RNA-binding protein 1) (PAI-RBP1) (Plasminogen activator inhibitor 1 RNA-binding protein) | Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (PubMed:36691768). Acts via its association with EEF2/eEF2 factor, sequestering EEF2/eEF2 at the A-site of the ribosome and promoting ribosome stabilization and storage in an inactive state (By similarity). May also play a role in the regulation of mRNA stability: binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay (PubMed:11001948). Seems to play a role in PML-nuclear bodies formation (PubMed:28695742). {ECO:0000250|UniProtKB:Q9CY58, ECO:0000269|PubMed:11001948, ECO:0000269|PubMed:28695742, ECO:0000269|PubMed:36691768}. |
| Q8NCN4 | RNF169 | S644 | ochoa | E3 ubiquitin-protein ligase RNF169 (EC 2.3.2.27) (RING finger protein 169) (RING-type E3 ubiquitin transferase RNF169) | Probable E3 ubiquitin-protein ligase that acts as a regulator of double-strand breaks (DSBs) repair following DNA damage. Functions in a non-canonical fashion to harness RNF168-mediated protein recruitment to DSB-containing chromatin, thereby contributing to regulation of DSB repair pathway utilization (PubMed:22492721, PubMed:30773093). Once recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168, competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby favouring homologous recombination repair (HRR) and single-strand annealing (SSA) instead of non-homologous end joining (NHEJ) mediated by TP53BP1 (PubMed:30104380, PubMed:30773093). E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair. {ECO:0000269|PubMed:22492721, ECO:0000269|PubMed:22733822, ECO:0000269|PubMed:22742833, ECO:0000269|PubMed:30104380, ECO:0000269|PubMed:30773093}. |
| Q8NE71 | ABCF1 | S595 | ochoa | ATP-binding cassette sub-family F member 1 (ATP-binding cassette 50) (TNF-alpha-stimulated ABC protein) | Isoform 2 is required for efficient Cap- and IRES-mediated mRNA translation initiation. Isoform 2 is not involved in the ribosome biogenesis. {ECO:0000269|PubMed:19570978}. |
| Q8TCG1 | CIP2A | S573 | ochoa | Protein CIP2A (Cancerous inhibitor of PP2A) (p90 autoantigen) | Acts as an inhibitor of protein phosphatase PP2A (PubMed:17632056). Promotes anchorage-independent cell growth and tumor formation by preventing dephosphorylation of MYC, thereby stabilizing MYC in human malignancies (PubMed:17632056). Together with TOPBP1, plays an essential role in the response to genome instability generated by the presence of acentric chromosome fragments derived from shattered chromosomes within micronuclei (PubMed:35121901, PubMed:35842428, PubMed:37165191, PubMed:37316668). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, the CIP2A-TOPBP1 complex tethers chromosome fragments during mitosis to ensure clustered segregation of the fragments to a single daughter cell nucleus, facilitating re-ligation with limited chromosome scattering and loss (PubMed:37165191, PubMed:37316668). {ECO:0000269|PubMed:17632056, ECO:0000269|PubMed:35121901, ECO:0000269|PubMed:35842428, ECO:0000269|PubMed:37165191, ECO:0000269|PubMed:37316668}. |
| Q8TEU7 | RAPGEF6 | S1437 | ochoa | Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2) | Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP. {ECO:0000269|PubMed:11524421, ECO:0000269|PubMed:12581858}. |
| Q8WWI1 | LMO7 | S709 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q92564 | DCUN1D4 | S71 | ochoa | DCN1-like protein 4 (DCNL4) (DCUN1 domain-containing protein 4) (Defective in cullin neddylation protein 1-like protein 4) | Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes which are necessary for the activation of cullin-RING E3 ubiquitin ligases (CRLs). {ECO:0000269|PubMed:23201271, ECO:0000269|PubMed:26906416}. |
| Q92576 | PHF3 | S707 | ochoa | PHD finger protein 3 | None |
| Q92616 | GCN1 | S1412 | ochoa | Stalled ribosome sensor GCN1 (GCN1 eIF-2-alpha kinase activator homolog) (GCN1-like protein 1) (General control of amino-acid synthesis 1-like protein 1) (Translational activator GCN1) (HsGCN1) | Ribosome collision sensor that plays a key role in the RNF14-RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation factors on stalled ribosomes (PubMed:32610081, PubMed:36638793, PubMed:37651229, PubMed:37951215, PubMed:37951216). Directly binds to the ribosome and acts as a sentinel for colliding ribosomes: activated following ribosome stalling and promotes recruitment of RNF14, which directly ubiquitinates EEF1A1/eEF1A, leading to its degradation (PubMed:36638793, PubMed:37951215, PubMed:37951216). In addition to EEF1A1/eEF1A, the RNF14-RNF25 translation quality control pathway mediates degradation of ETF1/eRF1 and ubiquitination of ribosomal protein (PubMed:36638793, PubMed:37651229). GCN1 also acts as a positive activator of the integrated stress response (ISR) by mediating activation of EIF2AK4/GCN2 in response to amino acid starvation (By similarity). Interaction with EIF2AK4/GCN2 on translating ribosomes stimulates EIF2AK4/GCN2 kinase activity, leading to phosphorylation of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) (By similarity). EIF2S1/eIF-2-alpha phosphorylation converts EIF2S1/eIF-2-alpha into a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, and thus to a reduced overall utilization of amino acids, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion (By similarity). {ECO:0000250|UniProtKB:E9PVA8, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:36638793, ECO:0000269|PubMed:37651229, ECO:0000269|PubMed:37951215, ECO:0000269|PubMed:37951216}. |
| Q92786 | PROX1 | S451 | ochoa | Prospero homeobox protein 1 (Homeobox prospero-like protein PROX1) (PROX-1) | Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3. {ECO:0000269|PubMed:23723244, ECO:0000303|PubMed:22733308}. |
| Q92793 | CREBBP | S1382 | psp | CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-) | Acetylates histones, giving a specific tag for transcriptional activation (PubMed:21131905, PubMed:24616510). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:24207024, PubMed:28790157, PubMed:30540930, PubMed:35675826, PubMed:9707565). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as lactoyl-CoA, and is able to mediate protein lactylation (PubMed:38128537). Catalyzes lactylation of MRE11 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR) (PubMed:38128537). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000269|PubMed:10490106, ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:24616510, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:30540930, ECO:0000269|PubMed:35675826, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9707565}. |
| Q96AQ6 | PBXIP1 | S469 | ochoa | Pre-B-cell leukemia transcription factor-interacting protein 1 (Hematopoietic PBX-interacting protein) | Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling. {ECO:0000269|PubMed:10825160, ECO:0000269|PubMed:12360403, ECO:0000269|PubMed:17043237}. |
| Q96AQ6 | PBXIP1 | S550 | ochoa | Pre-B-cell leukemia transcription factor-interacting protein 1 (Hematopoietic PBX-interacting protein) | Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling. {ECO:0000269|PubMed:10825160, ECO:0000269|PubMed:12360403, ECO:0000269|PubMed:17043237}. |
| Q96AT1 | KIAA1143 | S105 | ochoa | Uncharacterized protein KIAA1143 | None |
| Q96GA3 | LTV1 | S380 | ochoa | Protein LTV1 homolog | Essential for ribosome biogenesis. {ECO:0000250|UniProtKB:Q5U3J8}. |
| Q96MU7 | YTHDC1 | S120 | ochoa | YTH domain-containing protein 1 (Splicing factor YT521) (YT521-B) | Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:25242552, PubMed:26318451, PubMed:26876937, PubMed:28984244). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:25242552, PubMed:26318451). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May also regulate alternative splice site selection (PubMed:20167602). Also involved in nuclear export of m6A-containing mRNAs via interaction with SRSF3: interaction with SRSF3 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). Involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts, probably by binding m6A-containing MAT2A mRNAs (By similarity). Also recognizes and binds m6A on other RNA molecules (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: recognizes and binds m6A-containing Xist and promotes transcription repression activity of Xist (PubMed:27602518). Also recognizes and binds m6A-containing single-stranded DNA (PubMed:32663306). Involved in germline development: required for spermatogonial development in males and oocyte growth and maturation in females, probably via its role in alternative splicing (By similarity). {ECO:0000250|UniProtKB:E9Q5K9, ECO:0000269|PubMed:20167602, ECO:0000269|PubMed:25242552, ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:26876937, ECO:0000269|PubMed:27602518, ECO:0000269|PubMed:28984244, ECO:0000269|PubMed:32663306}. |
| Q96SB4 | SRPK1 | S587 | psp | SRSF protein kinase 1 (EC 2.7.11.1) (SFRS protein kinase 1) (Serine/arginine-rich protein-specific kinase 1) (SR-protein-specific kinase 1) | Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activities, such as chromatin reorganization in somatic and sperm cells and cell cycle progression. Isoform 2 phosphorylates SFRS2, ZRSR2, LBR and PRM1. Isoform 2 phosphorylates SRSF1 using a directional (C-terminal to N-terminal) and a dual-track mechanism incorporating both processive phosphorylation (in which the kinase stays attached to the substrate after each round of phosphorylation) and distributive phosphorylation steps (in which the kinase and substrate dissociate after each phosphorylation event). The RS domain of SRSF1 binds first to a docking groove in the large lobe of the kinase domain of SRPK1. This induces certain structural changes in SRPK1 and/or RRM2 domain of SRSF1, allowing RRM2 to bind the kinase and initiate phosphorylation. The cycles continue for several phosphorylation steps in a processive manner (steps 1-8) until the last few phosphorylation steps (approximately steps 9-12). During that time, a mechanical stress induces the unfolding of the beta-4 motif in RRM2, which then docks at the docking groove of SRPK1. This also signals RRM2 to begin to dissociate, which facilitates SRSF1 dissociation after phosphorylation is completed. Isoform 2 can mediate hepatitis B virus (HBV) core protein phosphorylation. It plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles. Isoform 1 and isoform 2 can induce splicing of exon 10 in MAPT/TAU. The ratio of isoform 1/isoform 2 plays a decisive role in determining cell fate in K-562 leukaemic cell line: isoform 2 favors proliferation where as isoform 1 favors differentiation. {ECO:0000269|PubMed:10049757, ECO:0000269|PubMed:10390541, ECO:0000269|PubMed:11509566, ECO:0000269|PubMed:12134018, ECO:0000269|PubMed:14555757, ECO:0000269|PubMed:15034300, ECO:0000269|PubMed:16122776, ECO:0000269|PubMed:16209947, ECO:0000269|PubMed:18155240, ECO:0000269|PubMed:18687337, ECO:0000269|PubMed:19240134, ECO:0000269|PubMed:19477182, ECO:0000269|PubMed:19886675, ECO:0000269|PubMed:20708644, ECO:0000269|PubMed:8208298, ECO:0000269|PubMed:9237760}. |
| Q99250 | SCN2A | S1968 | ochoa | Sodium channel protein type 2 subunit alpha (HBSC II) (Sodium channel protein brain II subunit alpha) (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2) | Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:1325650, PubMed:17021166, PubMed:28256214, PubMed:29844171). Implicated in the regulation of hippocampal replay occurring within sharp wave ripples (SPW-R) important for memory (By similarity). {ECO:0000250|UniProtKB:B1AWN6, ECO:0000269|PubMed:1325650, ECO:0000269|PubMed:17021166, ECO:0000269|PubMed:28256214, ECO:0000269|PubMed:29844171}. |
| Q99640 | PKMYT1 | S160 | ochoa | Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase) | Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins (PubMed:10373560, PubMed:10504341, PubMed:9001210, PubMed:9268380). Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation (PubMed:9001210, PubMed:9268380). May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect (PubMed:9001210, PubMed:9268380). {ECO:0000269|PubMed:10373560, ECO:0000269|PubMed:10504341, ECO:0000269|PubMed:9001210, ECO:0000269|PubMed:9268380}. |
| Q99848 | EBNA1BP2 | S207 | ochoa | Probable rRNA-processing protein EBP2 (EBNA1-binding protein 2) (Nucleolar protein p40) | Required for the processing of the 27S pre-rRNA. {ECO:0000250}. |
| Q9BRX2 | PELO | S52 | ochoa | Protein pelota homolog (hPelota) (Protein Dom34 homolog) | Component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:21448132, PubMed:23667253, PubMed:27543824, PubMed:27863242). In the Pelota-HBS1L complex, PELO recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel (PubMed:27543824, PubMed:27863242). Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (PubMed:21448132, PubMed:32006463). As part of the PINK1-regulated signaling, upon mitochondrial damage is recruited to the ribosome/mRNA-ribonucleoprotein complex associated to mitochondrial outer membrane thereby enabling the recruitment of autophagy receptors and induction of mitophagy (PubMed:29861391). {ECO:0000269|PubMed:21448132, ECO:0000269|PubMed:23667253, ECO:0000269|PubMed:27543824, ECO:0000269|PubMed:27863242, ECO:0000269|PubMed:29861391, ECO:0000269|PubMed:32006463}. |
| Q9BV44 | THUMPD3 | S154 | ochoa | tRNA (guanine(6)-N(2))-methyltransferase THUMP3 (EC 2.1.1.256) (THUMP domain-containing protein 3) (tRNA(Trp) (guanine(7)-N(2))-methyltransferase THUMP3) (EC 2.1.1.-) | Catalytic subunit of the THUMPD3-TRM112 methyltransferase complex, that specifically mediates the S-adenosyl-L-methionine-dependent N(2)-methylation of guanosine nucleotide at position 6 (m2G6) in tRNAs (PubMed:34669960, PubMed:37283053). This is one of the major tRNA (guanine-N(2))-methyltransferases (PubMed:37283053). Also catalyzes the S-adenosyl-L-methionine-dependent N(2)-methylation of guanosine nucleotide at position 7 of tRNA(Trp) (PubMed:34669960). {ECO:0000269|PubMed:34669960, ECO:0000269|PubMed:37283053}. |
| Q9BW71 | HIRIP3 | S196 | ochoa | HIRA-interacting protein 3 | Histone chaperone that carries a H2A-H2B histone complex and facilitates its deposition onto chromatin. {ECO:0000269|PubMed:38334665, ECO:0000269|PubMed:9710638}. |
| Q9BY42 | RTF2 | S272 | ochoa | Replication termination factor 2 (RTF2) (Replication termination factor 2 domain-containing protein 1) | Replication termination factor which is a component of the elongating replisome (Probable). Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion (Probable). Interacts with nascent DNA (PubMed:29290612). {ECO:0000269|PubMed:29290612, ECO:0000305|PubMed:29290612}. |
| Q9C0D2 | CEP295 | S1637 | ochoa | Centrosomal protein of 295 kDa | Centriole-enriched microtubule-binding protein involved in centriole biogenesis (PubMed:20844083, PubMed:25131205, PubMed:27185865, PubMed:38154379). Essential for the generation of the distal portion of new-born centrioles in a CPAP- and CEP120-mediated elongation dependent manner during the cell cycle S/G2 phase after formation of the initiating cartwheel structure (PubMed:27185865). Required for the recruitment of centriolar proteins, such as POC1B, POC5 and CEP135, into the distal portion of centrioles (PubMed:27185865). Also required for centriole-to-centrosome conversion during mitotic progression, but is dispensable for cartwheel removal or centriole disengagement (PubMed:25131205). Binds to and stabilizes centriolar microtubule (PubMed:27185865). May be involved in ciliogenesis (PubMed:38154379). {ECO:0000269|PubMed:20844083, ECO:0000269|PubMed:25131205, ECO:0000269|PubMed:27185865, ECO:0000269|PubMed:32060285, ECO:0000269|PubMed:38154379}. |
| Q9NP61 | ARFGAP3 | S211 | ochoa | ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3) | GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. {ECO:0000269|PubMed:11172815}. |
| Q9NQ84 | GPRC5C | S335 | ochoa | G-protein coupled receptor family C group 5 member C (Retinoic acid-induced gene 3 protein) (RAIG-3) | This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways. {ECO:0000250}. |
| Q9NRE2 | TSHZ2 | S980 | ochoa | Teashirt homolog 2 (Ovarian cancer-related protein 10-2) (OVC10-2) (Zinc finger protein 218) | Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential). {ECO:0000305}. |
| Q9NSI6 | BRWD1 | S2051 | ochoa | Bromodomain and WD repeat-containing protein 1 (WD repeat-containing protein 9) | May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000250, ECO:0000269|PubMed:21834987}. |
| Q9NTZ6 | RBM12 | S525 | ochoa | RNA-binding protein 12 (RNA-binding motif protein 12) (SH3/WW domain anchor protein in the nucleus) (SWAN) | None |
| Q9NUJ3 | TCP11L1 | S21 | ochoa | T-complex protein 11-like protein 1 | None |
| Q9NUL7 | DDX28 | S127 | ochoa | Probable ATP-dependent RNA helicase DDX28 (EC 3.6.4.13) (Mitochondrial DEAD box protein 28) | Plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function (PubMed:25683708, PubMed:25683715). May be involved in RNA processing or transport. Has RNA and Mg(2+)-dependent ATPase activity (PubMed:11350955). {ECO:0000269|PubMed:11350955, ECO:0000269|PubMed:25683708, ECO:0000269|PubMed:25683715}. |
| Q9NW13 | RBM28 | S202 | ochoa | RNA-binding protein 28 (RNA-binding motif protein 28) | Nucleolar component of the spliceosomal ribonucleoprotein complexes. {ECO:0000269|PubMed:17081119}. |
| Q9NYQ6 | CELSR1 | S2889 | ochoa | Cadherin EGF LAG seven-pass G-type receptor 1 (Cadherin family member 9) (Flamingo homolog 2) (hFmi2) | Receptor that may have an important role in cell/cell signaling during nervous system formation. |
| Q9NZJ0 | DTL | S535 | ochoa | Denticleless protein homolog (DDB1- and CUL4-associated factor 2) (Lethal(2) denticleless protein homolog) (Retinoic acid-regulated nuclear matrix-associated protein) | Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), FBH1, KMT5A and SDE2 (PubMed:16861906, PubMed:16949367, PubMed:16964240, PubMed:17085480, PubMed:18703516, PubMed:18794347, PubMed:18794348, PubMed:19332548, PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613, PubMed:27906959). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication (PubMed:16861906, PubMed:16949367, PubMed:17085480). CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing (PubMed:18794348, PubMed:19332548). KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration (PubMed:23478445). Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613). The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (PubMed:26431207). {ECO:0000269|PubMed:16861906, ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:17085480, ECO:0000269|PubMed:18703516, ECO:0000269|PubMed:18794347, ECO:0000269|PubMed:18794348, ECO:0000269|PubMed:19332548, ECO:0000269|PubMed:20129063, ECO:0000269|PubMed:23478441, ECO:0000269|PubMed:23478445, ECO:0000269|PubMed:23677613, ECO:0000269|PubMed:26431207, ECO:0000269|PubMed:27906959}. |
| Q9P0L2 | MARK1 | S444 | ochoa | Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (EC 2.7.11.26) (MAP/microtubule affinity-regulating kinase 1) (PAR1 homolog c) (Par-1c) (Par1c) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:17573348, ECO:0000269|PubMed:23666762}. |
| Q9P246 | STIM2 | S613 | ochoa | Stromal interaction molecule 2 | Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx. {ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16860747, ECO:0000269|PubMed:17905723, ECO:0000269|PubMed:18160041, ECO:0000269|PubMed:21217057, ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:23359669}. |
| Q9P2B7 | CFAP97 | S288 | ochoa | Cilia- and flagella-associated protein 97 | None |
| Q9P2E9 | RRBP1 | S1340 | ochoa | Ribosome-binding protein 1 (180 kDa ribosome receptor homolog) (RRp) (ES/130-related protein) (Ribosome receptor protein) | Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane. {ECO:0000250}. |
| Q9UGU5 | HMGXB4 | Y83 | ochoa | HMG domain-containing protein 4 (HMG box-containing protein 4) (High mobility group protein 2-like 1) (Protein HMGBCG) | Negatively regulates Wnt/beta-catenin signaling during development. {ECO:0000250}. |
| Q9UGU5 | HMGXB4 | S156 | ochoa | HMG domain-containing protein 4 (HMG box-containing protein 4) (High mobility group protein 2-like 1) (Protein HMGBCG) | Negatively regulates Wnt/beta-catenin signaling during development. {ECO:0000250}. |
| Q9UHD1 | CHORDC1 | T204 | ochoa | Cysteine and histidine-rich domain-containing protein 1 (CHORD domain-containing protein 1) (CHORD-containing protein 1) (CHP-1) (Protein morgana) | Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2 (PubMed:20230755). Proposed to act as co-chaperone for HSP90 (PubMed:20230755). May play a role in the regulation of NOD1 via a HSP90 chaperone complex (PubMed:20230755). In vitro, has intrinsic chaperone activity (PubMed:20230755). This function may be achieved by inhibiting association of ROCK2 with NPM1 (PubMed:20230755). Plays a role in ensuring the localization of the tyrosine kinase receptor EGFR to the plasma membrane, and thus ensures the subsequent regulation of EGFR activity and EGF-induced actin cytoskeleton remodeling (PubMed:32053105). Involved in stress response (PubMed:20230755). Prevents tumorigenesis (PubMed:20230755). {ECO:0000269|PubMed:20230755, ECO:0000269|PubMed:32053105}. |
| Q9UHD8 | SEPTIN9 | S332 | ochoa | Septin-9 (MLL septin-like fusion protein MSF-A) (MLL septin-like fusion protein) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1) | Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri. {ECO:0000250, ECO:0000305}. |
| Q9UIG0 | BAZ1B | S507 | ochoa | Tyrosine-protein kinase BAZ1B (EC 2.7.10.2) (Bromodomain adjacent to zinc finger domain protein 1B) (Williams syndrome transcription factor) (Williams-Beuren syndrome chromosomal region 10 protein) (Williams-Beuren syndrome chromosomal region 9 protein) (hWALp2) | Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator (PubMed:19092802). Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph) (PubMed:19092802, PubMed:19234442). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19092802, PubMed:19234442). Regulatory subunit of the ATP-dependent WICH-1 and WICH-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:11980720, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The WICH-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the WICH-5 ISWI chromatin remodeling complex (PubMed:28801535). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the recruitment of the WICH-5 ISWI chromatin remodeling complex to replication foci during DNA replication (PubMed:15543136). {ECO:0000250|UniProtKB:Q9Z277, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:19092802, ECO:0000269|PubMed:19234442, ECO:0000269|PubMed:28801535}. |
| Q9UIG0 | BAZ1B | S1127 | ochoa | Tyrosine-protein kinase BAZ1B (EC 2.7.10.2) (Bromodomain adjacent to zinc finger domain protein 1B) (Williams syndrome transcription factor) (Williams-Beuren syndrome chromosomal region 10 protein) (Williams-Beuren syndrome chromosomal region 9 protein) (hWALp2) | Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator (PubMed:19092802). Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph) (PubMed:19092802, PubMed:19234442). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19092802, PubMed:19234442). Regulatory subunit of the ATP-dependent WICH-1 and WICH-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:11980720, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The WICH-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the WICH-5 ISWI chromatin remodeling complex (PubMed:28801535). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the recruitment of the WICH-5 ISWI chromatin remodeling complex to replication foci during DNA replication (PubMed:15543136). {ECO:0000250|UniProtKB:Q9Z277, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:19092802, ECO:0000269|PubMed:19234442, ECO:0000269|PubMed:28801535}. |
| Q9UKG1 | APPL1 | S496 | ochoa | DCC-interacting protein 13-alpha (Dip13-alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1) | Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism (PubMed:10490823, PubMed:15016378, PubMed:19661063, PubMed:26073777, PubMed:26583432). Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex (PubMed:15016378). Functions as a positive regulator of innate immune response via activation of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1 (By similarity). Inhibits Fc-gamma receptor-mediated phagocytosis through PI3K/Akt signaling in macrophages (By similarity). Regulates TLR4 signaling in activated macrophages (By similarity). Involved in trafficking of the TGFBR1 from the endosomes to the nucleus via microtubules in a TRAF6-dependent manner (PubMed:26583432). Plays a role in cell metabolism by regulating adiponecting and insulin signaling pathways (PubMed:19661063, PubMed:24879834, PubMed:26073777). Required for fibroblast migration through HGF cell signaling (By similarity). Positive regulator of beta-catenin/TCF-dependent transcription through direct interaction with RUVBL2/reptin resulting in the relief of RUVBL2-mediated repression of beta-catenin/TCF target genes by modulating the interactions within the beta-catenin-reptin-HDAC complex (PubMed:19433865). {ECO:0000250|UniProtKB:Q8K3H0, ECO:0000269|PubMed:10490823, ECO:0000269|PubMed:15016378, ECO:0000269|PubMed:19433865, ECO:0000269|PubMed:19661063, ECO:0000269|PubMed:24879834, ECO:0000269|PubMed:26073777, ECO:0000269|PubMed:26583432}. |
| Q9UKI9 | POU2F3 | S287 | ochoa | POU domain, class 2, transcription factor 3 (Octamer-binding protein 11) (Oct-11) (Octamer-binding transcription factor 11) (OTF-11) (Transcription factor PLA-1) (Transcription factor Skn-1) | Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and regulates cell type-specific differentiation pathways. Involved in the regulation of keratinocytes differentiation (PubMed:11329378). The POU2F3-POU2AF2/POU2AF3 complex drives the expression of tuft-cell-specific genes, a rare chemosensory cells that coordinate immune and neural functions within mucosal epithelial tissues (PubMed:35576971). {ECO:0000269|PubMed:11329378, ECO:0000269|PubMed:35576971}. |
| Q9UKJ3 | GPATCH8 | S1107 | ochoa | G patch domain-containing protein 8 | None |
| Q9UKS6 | PACSIN3 | S181 | ochoa | Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) | Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:11082044}. |
| Q9UKV3 | ACIN1 | S714 | ochoa | Apoptotic chromatin condensation inducer in the nucleus (Acinus) | Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}. |
| Q9UKV5 | AMFR | S601 | ochoa | E3 ubiquitin-protein ligase AMFR (EC 2.3.2.36) (Autocrine motility factor receptor) (AMF receptor) (RING finger protein 45) (gp78) | E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation (PubMed:10456327, PubMed:11724934, PubMed:12670940, PubMed:19103148, PubMed:24424410, PubMed:28604676). Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD) (PubMed:10456327, PubMed:11724934, PubMed:19103148, PubMed:24424410). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG1 complex at the ER membrane (PubMed:16168377, PubMed:22143767). In addition, interaction of AMFR with AUP1 facilitates interaction of AMFR with ubiquitin-conjugating enzyme UBE2G2 and ubiquitin ligase RNF139, leading to sterol-induced HMGCR ubiquitination (PubMed:23223569). The ubiquitinated HMGCR is then released from the ER into the cytosol for subsequent destruction (PubMed:16168377, PubMed:22143767, PubMed:23223569). In addition to ubiquitination on lysine residues, catalyzes ubiquitination on cysteine residues: together with INSIG1, mediates polyubiquitination of SOAT2/ACAT2 at 'Cys-277', leading to its degradation when the lipid levels are low (PubMed:28604676). Catalyzes ubiquitination and subsequent degradation of INSIG1 when cells are depleted of sterols (PubMed:17043353). Mediates polyubiquitination of INSIG2 at 'Cys-215' in some tissues, leading to its degradation (PubMed:31953408). Also regulates ERAD through the ubiquitination of UBL4A a component of the BAG6/BAT3 complex (PubMed:21636303). Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation (PubMed:21636303). Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor (PubMed:10456327). In association with LMBR1L and UBAC2, negatively regulates the canonical Wnt signaling pathway in the lymphocytes by promoting the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (PubMed:31073040). Regulates NF-kappa-B and MAPK signaling pathways by mediating 'Lys-27'-linked polyubiquitination of TAB3 and promoting subsequent TAK1/MAP3K7 activation (PubMed:36593296). Required for proper lipid homeostasis (PubMed:37119330). {ECO:0000269|PubMed:10456327, ECO:0000269|PubMed:11724934, ECO:0000269|PubMed:12670940, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:17043353, ECO:0000269|PubMed:19103148, ECO:0000269|PubMed:21636303, ECO:0000269|PubMed:22143767, ECO:0000269|PubMed:23223569, ECO:0000269|PubMed:24424410, ECO:0000269|PubMed:28604676, ECO:0000269|PubMed:31073040, ECO:0000269|PubMed:31953408, ECO:0000269|PubMed:36593296, ECO:0000269|PubMed:37119330}. |
| Q9UKX2 | MYH2 | S1605 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UMS6 | SYNPO2 | S519 | ochoa | Synaptopodin-2 (Genethonin-2) (Myopodin) | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. |
| Q9UPR0 | PLCL2 | S125 | ochoa | Inactive phospholipase C-like protein 2 (PLC-L(2)) (PLC-L2) (Phospholipase C-L2) (Phospholipase C-epsilon-2) (PLC-epsilon-2) | May play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum. {ECO:0000250}. |
| Q9UPY3 | DICER1 | S1016 | ochoa|psp | Endoribonuclease Dicer (EC 3.1.26.3) (Helicase with RNase motif) (Helicase MOI) | Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes. {ECO:0000269|PubMed:15242644, ECO:0000269|PubMed:15973356, ECO:0000269|PubMed:16142218, ECO:0000269|PubMed:16271387, ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:16357216, ECO:0000269|PubMed:16424907, ECO:0000269|PubMed:17452327, ECO:0000269|PubMed:18178619}. |
| Q9Y210 | TRPC6 | S839 | ochoa | Short transient receptor potential channel 6 (TrpC6) (Transient receptor protein 6) (TRP-6) | Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:19936226, PubMed:23291369, PubMed:26892346, PubMed:9930701). Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C (PubMed:26892346). Seems not to be activated by intracellular calcium store depletion. {ECO:0000269|PubMed:19936226, ECO:0000269|PubMed:23291369, ECO:0000269|PubMed:26892346, ECO:0000269|PubMed:9930701}. |
| Q9Y3B9 | RRP15 | S240 | ochoa | RRP15-like protein (Ribosomal RNA-processing protein 15) | None |
| Q9Y462 | ZNF711 | S230 | ochoa | Zinc finger protein 711 (Zinc finger protein 6) | Transcription regulator required for brain development (PubMed:20346720). Probably acts as a transcription factor that binds to the promoter of target genes and recruits PHF8 histone demethylase, leading to activated expression of genes involved in neuron development, such as KDM5C (PubMed:20346720, PubMed:31691806). May compete with transcription factor ARX for activation of expression of KDM5C (PubMed:31691806). {ECO:0000269|PubMed:20346720, ECO:0000269|PubMed:31691806}. |
| Q9Y5B0 | CTDP1 | S904 | ochoa | RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) (TFIIF-associating CTD phosphatase) | Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation. {ECO:0000269|PubMed:22692537}. |
| Q9Y5S9 | RBM8A | S42 | ochoa | RNA-binding protein 8A (Binder of OVCA1-1) (BOV-1) (RNA-binding motif protein 8A) (RNA-binding protein Y14) (Ribonucleoprotein RBM8A) | Required for pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:29301961). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator PYM1 leading to EJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Its removal from cytoplasmic mRNAs requires translation initiation from EJC-bearing spliced mRNAs. Associates preferentially with mRNAs produced by splicing. Does not interact with pre-mRNAs, introns, or mRNAs produced from intronless cDNAs. Associates with both nuclear mRNAs and newly exported cytoplasmic mRNAs. The MAGOH-RBM8A heterodimer is a component of the nonsense mediated decay (NMD) pathway. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the function is different from the established EJC assembly. {ECO:0000269|PubMed:12121612, ECO:0000269|PubMed:12718880, ECO:0000269|PubMed:12730685, ECO:0000269|PubMed:16209946, ECO:0000269|PubMed:19409878, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961}. |
| Q9Y6J0 | CABIN1 | S386 | ochoa | Calcineurin-binding protein cabin-1 (Calcineurin inhibitor) (CAIN) | May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:9655484}. |
| Q14683 | SMC1A | S514 | Sugiyama | Structural maintenance of chromosomes protein 1A (SMC protein 1A) (SMC-1-alpha) (SMC-1A) (Sb1.8) | Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint. {ECO:0000269|PubMed:11877377}. |
| Q53F19 | NCBP3 | S100 | EPSD|PSP | Nuclear cap-binding protein subunit 3 (Protein ELG) | Associates with NCBP1/CBP80 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export. The alternative CBC is particularly important in cellular stress situations such as virus infections and the NCBP3 activity is critical to inhibit virus growth (PubMed:26382858). {ECO:0000269|PubMed:26382858}. |
| Q15118 | PDK1 | S396 | EPSD | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 1) (PDH kinase 1) | Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2 (PubMed:7499431, PubMed:18541534, PubMed:22195962, PubMed:26942675, PubMed:17683942). This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate (PubMed:18541534, PubMed:22195962, PubMed:26942675). Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia (PubMed:18541534, PubMed:22195962, PubMed:26942675). {ECO:0000269|PubMed:17683942, ECO:0000269|PubMed:18541534, ECO:0000269|PubMed:22195962, ECO:0000269|PubMed:26942675, ECO:0000269|PubMed:7499431}. |
| O75914 | PAK3 | S239 | Sugiyama | Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (Beta-PAK) (Oligophrenin-3) (p21-activated kinase 3) (PAK-3) | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as a downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity). {ECO:0000250|UniProtKB:Q61036, ECO:0000269|PubMed:21177870}. |
| Q96E11 | MRRF | S239 | Sugiyama | Ribosome-recycling factor, mitochondrial (RRF) (mtRRF) (Ribosome-releasing factor, mitochondrial) | Responsible for the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis (PubMed:19716793, PubMed:33878294). Acts in collaboration with GFM2 (PubMed:33878294). Promotes mitochondrial ribosome recycling by dissolution of intersubunit contacts (PubMed:33878294). {ECO:0000269|PubMed:19716793, ECO:0000269|PubMed:33878294}. |
| Q99575 | POP1 | S816 | Sugiyama | Ribonucleases P/MRP protein subunit POP1 (hPOP1) | Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:30454648, PubMed:8918471). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465). {ECO:0000269|PubMed:28115465, ECO:0000269|PubMed:30454648, ECO:0000269|PubMed:8918471}. |
| P49756 | RBM25 | Y717 | Sugiyama | RNA-binding protein 25 (Arg/Glu/Asp-rich protein of 120 kDa) (RED120) (Protein S164) (RNA-binding motif protein 25) (RNA-binding region-containing protein 7) | RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA. Also involved in the generation of an abnormal and truncated splice form of SCN5A in heart failure. {ECO:0000269|PubMed:18663000, ECO:0000269|PubMed:21859973}. |
| P08631 | HCK | S130 | Sugiyama | Tyrosine-protein kinase HCK (EC 2.7.10.2) (Hematopoietic cell kinase) (Hemopoietic cell kinase) (p59-HCK/p60-HCK) (p59Hck) (p61Hck) | Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS. {ECO:0000269|PubMed:10092522, ECO:0000269|PubMed:10779760, ECO:0000269|PubMed:10973280, ECO:0000269|PubMed:11741929, ECO:0000269|PubMed:11896602, ECO:0000269|PubMed:12411494, ECO:0000269|PubMed:15010462, ECO:0000269|PubMed:15952790, ECO:0000269|PubMed:15998323, ECO:0000269|PubMed:17310994, ECO:0000269|PubMed:17535448, ECO:0000269|PubMed:19114024, ECO:0000269|PubMed:19903482, ECO:0000269|PubMed:20452982, ECO:0000269|PubMed:21338576, ECO:0000269|PubMed:7535819, ECO:0000269|PubMed:8132624, ECO:0000269|PubMed:9406996, ECO:0000269|PubMed:9407116}. |
| P35579 | MYH9 | S131 | Sugiyama | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| Q9Y639 | NPTN | S213 | Sugiyama | Neuroplastin (Stromal cell-derived receptor 1) (SDR-1) | Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK. May also regulate neurite outgrowth by activating the FGFR1 signaling pathway. May play a role in synaptic plasticity (By similarity). Also acts as a chaperone for ATP2B1; stabilizes ATP2B1 and increases its ATPase activity (PubMed:30190470). Promotes localization of XKR8 at the cell membrane (PubMed:27503893). {ECO:0000250|UniProtKB:P97546, ECO:0000269|PubMed:27503893, ECO:0000269|PubMed:30190470}. |
| P16333 | NCK1 | S53 | Sugiyama | SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha) | Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors. {ECO:0000269|PubMed:10026169, ECO:0000269|PubMed:16835242, ECO:0000269|PubMed:17803907, ECO:0000269|PubMed:18835251, ECO:0000269|PubMed:23358419, ECO:0000269|PubMed:9430661}. |
| O60479 | DLX3 | S137 | iPTMNet|EPSD | Homeobox protein DLX-3 | Transcriptional activator (By similarity). Activates transcription of GNRHR, via binding to the downstream activin regulatory element (DARE) in the gene promoter (By similarity). {ECO:0000250|UniProtKB:Q64205}. |
| Q12959 | DLG1 | S733 | Sugiyama | Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (SAP97) (hDlg) | Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). May also play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel. During long-term depression in hippocampal neurons, it recruits ADAM10 to the plasma membrane (PubMed:23676497). {ECO:0000250|UniProtKB:A0A8C0TYJ0, ECO:0000250|UniProtKB:Q811D0, ECO:0000269|PubMed:10656683, ECO:0000269|PubMed:12445884, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15263016, ECO:0000269|PubMed:19213956, ECO:0000269|PubMed:20605917, ECO:0000269|PubMed:23676497}. |
| Q15700 | DLG2 | S699 | Sugiyama | Disks large homolog 2 (Channel-associated protein of synapse-110) (Chapsyn-110) (Postsynaptic density protein PSD-93) | Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity). {ECO:0000250}. |
| Q92915 | FGF14 | S226 | SIGNOR | Fibroblast growth factor 14 (FGF-14) (Fibroblast growth factor homologous factor 4) (FHF-4) | Probably involved in nervous system development and function. |
| Q9Y5K3 | PCYT1B | S260 | GPS6 | Choline-phosphate cytidylyltransferase B (EC 2.7.7.15) (CCT-beta) (CTP:phosphocholine cytidylyltransferase B) (CCT B) (CT B) (Phosphorylcholine transferase B) | [Isoform 1]: Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. {ECO:0000269|PubMed:10480912, ECO:0000269|PubMed:9593753}.; FUNCTION: [Isoform 2]: Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. {ECO:0000269|PubMed:10480912}. |
| P51957 | NEK4 | S723 | Sugiyama | Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) | Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage. {ECO:0000250|UniProtKB:Q9Z1J2, ECO:0000269|PubMed:22851694}. |
| O75128 | COBL | S1174 | Sugiyama | Protein cordon-bleu | Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. {ECO:0000250, ECO:0000269|PubMed:21816349}. |
| P61927 | RPL37 | S50 | Sugiyama | Large ribosomal subunit protein eL37 (60S ribosomal protein L37) (G1.16) | Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| Q16555 | DPYSL2 | Y275 | Sugiyama | Dihydropyrimidinase-related protein 2 (DRP-2) (Collapsin response mediator protein 2) (CRMP-2) (N2A3) (Unc-33-like phosphoprotein 2) (ULIP-2) | Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis. {ECO:0000269|PubMed:11477421, ECO:0000269|PubMed:15466863, ECO:0000269|PubMed:20801876}. |
| O00273 | DFFA | S90 | Sugiyama | DNA fragmentation factor subunit alpha (DNA fragmentation factor 45 kDa subunit) (DFF-45) (Inhibitor of CAD) (ICAD) | Inhibitor of the caspase-activated DNase (DFF40). |
| Q8IY84 | NIM1K | S119 | Sugiyama | Serine/threonine-protein kinase NIM1 (EC 2.7.11.1) (NIM1 serine/threonine-protein kinase) | None |
| Q9H2J4 | PDCL3 | S151 | Sugiyama | Phosducin-like protein 3 (HTPHLP) (PhPL3) (Viral IAP-associated factor 1) (VIAF-1) | Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation (PubMed:23792958, PubMed:26059764). Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding (PubMed:17429077). Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity). Modulates the activation of caspases during apoptosis (PubMed:15371430). {ECO:0000250|UniProtKB:Q4KLJ8, ECO:0000269|PubMed:15371430, ECO:0000269|PubMed:17429077, ECO:0000269|PubMed:23792958, ECO:0000269|PubMed:26059764}. |
| Q9GZT8 | NIF3L1 | S193 | Sugiyama | NIF3-like protein 1 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 1 protein) | May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation. {ECO:0000250|UniProtKB:Q9EQ80}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-5693606 | DNA Double Strand Break Response | 0.000467 | 3.330 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 0.000389 | 3.410 |
| R-HSA-422475 | Axon guidance | 0.000425 | 3.371 |
| R-HSA-9675108 | Nervous system development | 0.000330 | 3.482 |
| R-HSA-428540 | Activation of RAC1 | 0.001022 | 2.991 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.005325 | 2.274 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.005325 | 2.274 |
| R-HSA-3928664 | Ephrin signaling | 0.003417 | 2.466 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.002072 | 2.684 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.001879 | 2.726 |
| R-HSA-174577 | Activation of C3 and C5 | 0.003797 | 2.421 |
| R-HSA-373753 | Nephrin family interactions | 0.004307 | 2.366 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.001538 | 2.813 |
| R-HSA-9706374 | FLT3 signaling through SRC family kinases | 0.002814 | 2.551 |
| R-HSA-194138 | Signaling by VEGF | 0.002426 | 2.615 |
| R-HSA-912631 | Regulation of signaling by CBL | 0.003846 | 2.415 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.001730 | 2.762 |
| R-HSA-73894 | DNA Repair | 0.004063 | 2.391 |
| R-HSA-373752 | Netrin-1 signaling | 0.004808 | 2.318 |
| R-HSA-9664407 | Parasite infection | 0.004517 | 2.345 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.004517 | 2.345 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.004517 | 2.345 |
| R-HSA-447038 | NrCAM interactions | 0.003797 | 2.421 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.005325 | 2.274 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.006216 | 2.206 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.006216 | 2.206 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.005883 | 2.230 |
| R-HSA-164944 | Nef and signal transduction | 0.006172 | 2.210 |
| R-HSA-9669938 | Signaling by KIT in disease | 0.005883 | 2.230 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.007081 | 2.150 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.007102 | 2.149 |
| R-HSA-373760 | L1CAM interactions | 0.007119 | 2.148 |
| R-HSA-9620244 | Long-term potentiation | 0.007764 | 2.110 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.007764 | 2.110 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.008436 | 2.074 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.009193 | 2.037 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.010748 | 1.969 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.011182 | 1.951 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 0.012453 | 1.905 |
| R-HSA-451308 | Activation of Ca-permeable Kainate Receptor | 0.012453 | 1.905 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.011796 | 1.928 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.013095 | 1.883 |
| R-HSA-186763 | Downstream signal transduction | 0.012484 | 1.904 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.016305 | 1.788 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.015340 | 1.814 |
| R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 0.016305 | 1.788 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 0.016368 | 1.786 |
| R-HSA-451306 | Ionotropic activity of kainate receptors | 0.014322 | 1.844 |
| R-HSA-373755 | Semaphorin interactions | 0.013861 | 1.858 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.016044 | 1.795 |
| R-HSA-210990 | PECAM1 interactions | 0.014322 | 1.844 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 0.025383 | 1.595 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 0.025383 | 1.595 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 0.025383 | 1.595 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 0.025383 | 1.595 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 0.025383 | 1.595 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 0.020596 | 1.686 |
| R-HSA-399956 | CRMPs in Sema3A signaling | 0.022898 | 1.640 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.021161 | 1.674 |
| R-HSA-72172 | mRNA Splicing | 0.026827 | 1.571 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.025302 | 1.597 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.018452 | 1.734 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.025302 | 1.597 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.019558 | 1.709 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.022898 | 1.640 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.019558 | 1.709 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.025949 | 1.586 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.027433 | 1.562 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.025773 | 1.589 |
| R-HSA-9833482 | PKR-mediated signaling | 0.027711 | 1.557 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.025728 | 1.590 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.024718 | 1.607 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.027318 | 1.564 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.022367 | 1.650 |
| R-HSA-8953854 | Metabolism of RNA | 0.028487 | 1.545 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.028725 | 1.542 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.030399 | 1.517 |
| R-HSA-2892247 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | 0.030399 | 1.517 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.031545 | 1.501 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.036317 | 1.440 |
| R-HSA-9636667 | Manipulation of host energy metabolism | 0.037834 | 1.422 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.036614 | 1.436 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 0.035866 | 1.445 |
| R-HSA-73893 | DNA Damage Bypass | 0.037953 | 1.421 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.041137 | 1.386 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.040810 | 1.389 |
| R-HSA-391251 | Protein folding | 0.043676 | 1.360 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 0.041679 | 1.380 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.038945 | 1.410 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.038945 | 1.410 |
| R-HSA-9694631 | Maturation of nucleoprotein | 0.038730 | 1.412 |
| R-HSA-9658195 | Leishmania infection | 0.042147 | 1.375 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.042147 | 1.375 |
| R-HSA-2029481 | FCGR activation | 0.044978 | 1.347 |
| R-HSA-1266738 | Developmental Biology | 0.045089 | 1.346 |
| R-HSA-72312 | rRNA processing | 0.045690 | 1.340 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 0.047818 | 1.320 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.048859 | 1.311 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.049014 | 1.310 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 0.057594 | 1.240 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.051108 | 1.292 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.057594 | 1.240 |
| R-HSA-9708296 | tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis | 0.050125 | 1.300 |
| R-HSA-8985801 | Regulation of cortical dendrite branching | 0.050125 | 1.300 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 0.054263 | 1.265 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.050394 | 1.298 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.050394 | 1.298 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 0.054263 | 1.265 |
| R-HSA-8875791 | MET activates STAT3 | 0.062261 | 1.206 |
| R-HSA-198745 | Signalling to STAT3 | 0.062261 | 1.206 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 0.074242 | 1.129 |
| R-HSA-9818035 | NFE2L2 regulating ER-stress associated genes | 0.074242 | 1.129 |
| R-HSA-9818026 | NFE2L2 regulating inflammation associated genes | 0.086071 | 1.065 |
| R-HSA-9032759 | NTRK2 activates RAC1 | 0.086071 | 1.065 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 0.120663 | 0.918 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 0.120663 | 0.918 |
| R-HSA-9032500 | Activated NTRK2 signals through FYN | 0.131902 | 0.880 |
| R-HSA-8875656 | MET receptor recycling | 0.131902 | 0.880 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 0.142998 | 0.845 |
| R-HSA-9634635 | Estrogen-stimulated signaling through PRKCZ | 0.142998 | 0.845 |
| R-HSA-5218900 | CASP8 activity is inhibited | 0.142998 | 0.845 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 0.153952 | 0.813 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.164767 | 0.783 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.067994 | 1.168 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.196394 | 0.707 |
| R-HSA-170660 | Adenylate cyclase activating pathway | 0.196394 | 0.707 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.196394 | 0.707 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 0.216813 | 0.664 |
| R-HSA-170670 | Adenylate cyclase inhibitory pathway | 0.216813 | 0.664 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 0.216813 | 0.664 |
| R-HSA-8964616 | G beta:gamma signalling through CDC42 | 0.236717 | 0.626 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 0.265631 | 0.576 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.265631 | 0.576 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.265631 | 0.576 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.275025 | 0.561 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.275025 | 0.561 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.275025 | 0.561 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.275025 | 0.561 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.284300 | 0.546 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.185371 | 0.732 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.328930 | 0.483 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.345996 | 0.461 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.345996 | 0.461 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.345996 | 0.461 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.213274 | 0.671 |
| R-HSA-191859 | snRNP Assembly | 0.213274 | 0.671 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.141993 | 0.848 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.354367 | 0.451 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.354367 | 0.451 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.354367 | 0.451 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.153989 | 0.813 |
| R-HSA-192823 | Viral mRNA Translation | 0.182056 | 0.740 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.198204 | 0.703 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.279444 | 0.554 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.321912 | 0.492 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 0.196394 | 0.707 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.064461 | 1.191 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.108121 | 0.966 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 0.082726 | 1.082 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.077241 | 1.112 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 0.075243 | 1.124 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.149150 | 0.826 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.077241 | 1.112 |
| R-HSA-156902 | Peptide chain elongation | 0.130332 | 0.885 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.354367 | 0.451 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.226829 | 0.644 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.345996 | 0.461 |
| R-HSA-5693538 | Homology Directed Repair | 0.241608 | 0.617 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.185986 | 0.731 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.123086 | 0.910 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.221354 | 0.655 |
| R-HSA-8849474 | PTK6 Activates STAT3 | 0.086071 | 1.065 |
| R-HSA-165158 | Activation of AKT2 | 0.086071 | 1.065 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.201475 | 0.696 |
| R-HSA-9692913 | SARS-CoV-1-mediated effects on programmed cell death | 0.074242 | 1.129 |
| R-HSA-426486 | Small interfering RNA (siRNA) biogenesis | 0.109280 | 0.961 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.157037 | 0.804 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 0.153952 | 0.813 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 0.175445 | 0.756 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.067994 | 1.168 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 0.226829 | 0.644 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.158070 | 0.801 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.227376 | 0.643 |
| R-HSA-69478 | G2/M DNA replication checkpoint | 0.109280 | 0.961 |
| R-HSA-9020933 | Interleukin-23 signaling | 0.131902 | 0.880 |
| R-HSA-8866904 | Negative regulation of activity of TFAP2 (AP-2) family transcription factors | 0.131902 | 0.880 |
| R-HSA-3371378 | Regulation by c-FLIP | 0.131902 | 0.880 |
| R-HSA-9693928 | Defective RIPK1-mediated regulated necrosis | 0.153952 | 0.813 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 0.175445 | 0.756 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.175445 | 0.756 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 0.071588 | 1.145 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.216813 | 0.664 |
| R-HSA-164378 | PKA activation in glucagon signalling | 0.256116 | 0.592 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.302495 | 0.519 |
| R-HSA-977443 | GABA receptor activation | 0.217966 | 0.662 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.157037 | 0.804 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.160103 | 0.796 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.331277 | 0.480 |
| R-HSA-1500620 | Meiosis | 0.335947 | 0.474 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.180772 | 0.743 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 0.064461 | 1.191 |
| R-HSA-397795 | G-protein beta:gamma signalling | 0.090425 | 1.044 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.127349 | 0.895 |
| R-HSA-8854691 | Interleukin-20 family signaling | 0.311420 | 0.507 |
| R-HSA-9686347 | Microbial modulation of RIPK1-mediated regulated necrosis | 0.120663 | 0.918 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 0.185986 | 0.731 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.144962 | 0.839 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 0.131902 | 0.880 |
| R-HSA-3295583 | TRP channels | 0.064461 | 1.191 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.127349 | 0.895 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.269966 | 0.569 |
| R-HSA-9020958 | Interleukin-21 signaling | 0.142998 | 0.845 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 0.216813 | 0.664 |
| R-HSA-8985947 | Interleukin-9 signaling | 0.131902 | 0.880 |
| R-HSA-418889 | Caspase activation via Dependence Receptors in the absence of ligand | 0.142998 | 0.845 |
| R-HSA-203927 | MicroRNA (miRNA) biogenesis | 0.328930 | 0.483 |
| R-HSA-437239 | Recycling pathway of L1 | 0.158070 | 0.801 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.147951 | 0.830 |
| R-HSA-69416 | Dimerization of procaspase-8 | 0.131902 | 0.880 |
| R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 0.071588 | 1.145 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.118859 | 0.925 |
| R-HSA-432142 | Platelet sensitization by LDL | 0.256116 | 0.592 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 0.320231 | 0.495 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.201475 | 0.696 |
| R-HSA-202403 | TCR signaling | 0.208054 | 0.682 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.106412 | 0.973 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.119031 | 0.924 |
| R-HSA-1059683 | Interleukin-6 signaling | 0.196394 | 0.707 |
| R-HSA-2028269 | Signaling by Hippo | 0.246479 | 0.608 |
| R-HSA-8983432 | Interleukin-15 signaling | 0.185986 | 0.731 |
| R-HSA-73887 | Death Receptor Signaling | 0.181977 | 0.740 |
| R-HSA-112040 | G-protein mediated events | 0.251008 | 0.600 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 0.109280 | 0.961 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.090425 | 1.044 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.227376 | 0.643 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.175701 | 0.755 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.184526 | 0.734 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.071134 | 1.148 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.236717 | 0.626 |
| R-HSA-2586552 | Signaling by Leptin | 0.153952 | 0.813 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.062434 | 1.205 |
| R-HSA-8866376 | Reelin signalling pathway | 0.086071 | 1.065 |
| R-HSA-199920 | CREB phosphorylation | 0.109280 | 0.961 |
| R-HSA-8948747 | Regulation of PTEN localization | 0.120663 | 0.918 |
| R-HSA-444257 | RSK activation | 0.131902 | 0.880 |
| R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 0.142998 | 0.845 |
| R-HSA-9020956 | Interleukin-27 signaling | 0.153952 | 0.813 |
| R-HSA-418890 | Role of second messengers in netrin-1 signaling | 0.185986 | 0.731 |
| R-HSA-877312 | Regulation of IFNG signaling | 0.185986 | 0.731 |
| R-HSA-75892 | Platelet Adhesion to exposed collagen | 0.196394 | 0.707 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.226829 | 0.644 |
| R-HSA-163615 | PKA activation | 0.256116 | 0.592 |
| R-HSA-110320 | Translesion Synthesis by POLH | 0.265631 | 0.576 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.090046 | 1.046 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.062278 | 1.206 |
| R-HSA-392451 | G beta:gamma signalling through PI3Kgamma | 0.311420 | 0.507 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.180772 | 0.743 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.331767 | 0.479 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.110521 | 0.957 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.086071 | 1.065 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 0.097750 | 1.010 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 0.131902 | 0.880 |
| R-HSA-111453 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | 0.131902 | 0.880 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 0.216813 | 0.664 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 0.246479 | 0.608 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.256116 | 0.592 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.144730 | 0.839 |
| R-HSA-5357801 | Programmed Cell Death | 0.165712 | 0.781 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.234820 | 0.629 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.345996 | 0.461 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.256116 | 0.592 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.155354 | 0.809 |
| R-HSA-202433 | Generation of second messenger molecules | 0.123086 | 0.910 |
| R-HSA-6783589 | Interleukin-6 family signaling | 0.320231 | 0.495 |
| R-HSA-5689877 | Josephin domain DUBs | 0.153952 | 0.813 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 0.302495 | 0.519 |
| R-HSA-69481 | G2/M Checkpoints | 0.111967 | 0.951 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.234820 | 0.629 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.082726 | 1.082 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.105457 | 0.977 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 0.153952 | 0.813 |
| R-HSA-9659379 | Sensory processing of sound | 0.102820 | 0.988 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.101710 | 0.993 |
| R-HSA-9856872 | Malate-aspartate shuttle | 0.206669 | 0.685 |
| R-HSA-9673770 | Signaling by PDGFRA extracellular domain mutants | 0.216813 | 0.664 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 0.216813 | 0.664 |
| R-HSA-9673767 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 0.216813 | 0.664 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.275025 | 0.561 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.075677 | 1.121 |
| R-HSA-111931 | PKA-mediated phosphorylation of CREB | 0.284300 | 0.546 |
| R-HSA-9711097 | Cellular response to starvation | 0.192241 | 0.716 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.241608 | 0.617 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.232210 | 0.634 |
| R-HSA-75153 | Apoptotic execution phase | 0.153598 | 0.814 |
| R-HSA-168255 | Influenza Infection | 0.113709 | 0.944 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.311157 | 0.507 |
| R-HSA-111933 | Calmodulin induced events | 0.106412 | 0.973 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.262153 | 0.581 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.067299 | 1.172 |
| R-HSA-111997 | CaM pathway | 0.106412 | 0.973 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.194946 | 0.710 |
| R-HSA-8852135 | Protein ubiquitination | 0.288913 | 0.539 |
| R-HSA-109581 | Apoptosis | 0.084257 | 1.074 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 0.284300 | 0.546 |
| R-HSA-6806834 | Signaling by MET | 0.312514 | 0.505 |
| R-HSA-8984722 | Interleukin-35 Signalling | 0.185986 | 0.731 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 0.114670 | 0.941 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 0.164767 | 0.783 |
| R-HSA-9683610 | Maturation of nucleoprotein | 0.196394 | 0.707 |
| R-HSA-8876725 | Protein methylation | 0.216813 | 0.664 |
| R-HSA-9733709 | Cardiogenesis | 0.090425 | 1.044 |
| R-HSA-111996 | Ca-dependent events | 0.135977 | 0.867 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.284300 | 0.546 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 0.167087 | 0.777 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.311420 | 0.507 |
| R-HSA-901032 | ER Quality Control Compartment (ERQC) | 0.345996 | 0.461 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.149150 | 0.826 |
| R-HSA-162582 | Signal Transduction | 0.220181 | 0.657 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.230009 | 0.638 |
| R-HSA-8939211 | ESR-mediated signaling | 0.115915 | 0.936 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.216122 | 0.665 |
| R-HSA-3371556 | Cellular response to heat stress | 0.251849 | 0.599 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.087345 | 1.059 |
| R-HSA-9842663 | Signaling by LTK | 0.185986 | 0.731 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.216813 | 0.664 |
| R-HSA-9678110 | Attachment and Entry | 0.226829 | 0.644 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.080346 | 1.095 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.337518 | 0.472 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.176916 | 0.752 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.185257 | 0.732 |
| R-HSA-112043 | PLC beta mediated events | 0.222667 | 0.652 |
| R-HSA-9824446 | Viral Infection Pathways | 0.223996 | 0.650 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.144730 | 0.839 |
| R-HSA-9694614 | Attachment and Entry | 0.293456 | 0.532 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.320231 | 0.495 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.320231 | 0.495 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.326599 | 0.486 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.229482 | 0.639 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.149150 | 0.826 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.322782 | 0.491 |
| R-HSA-4839726 | Chromatin organization | 0.265770 | 0.575 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.338757 | 0.470 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.293456 | 0.532 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 0.328930 | 0.483 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.345996 | 0.461 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.354367 | 0.451 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.221354 | 0.655 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.345996 | 0.461 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.064461 | 1.191 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.328930 | 0.483 |
| R-HSA-913531 | Interferon Signaling | 0.151734 | 0.819 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.256116 | 0.592 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.311420 | 0.507 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.256116 | 0.592 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.100210 | 0.999 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.208969 | 0.680 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.224817 | 0.648 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.195771 | 0.708 |
| R-HSA-186797 | Signaling by PDGF | 0.062434 | 1.205 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.288913 | 0.539 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.197441 | 0.705 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.223162 | 0.651 |
| R-HSA-1500931 | Cell-Cell communication | 0.265323 | 0.576 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.087577 | 1.058 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 0.265631 | 0.576 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.337518 | 0.472 |
| R-HSA-9679506 | SARS-CoV Infections | 0.125736 | 0.901 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.106779 | 0.972 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.105530 | 0.977 |
| R-HSA-9607240 | FLT3 Signaling | 0.127349 | 0.895 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.298369 | 0.525 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.176316 | 0.754 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.217966 | 0.662 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.345257 | 0.462 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.169411 | 0.771 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.354524 | 0.450 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.356211 | 0.448 |
| R-HSA-5663205 | Infectious disease | 0.358432 | 0.446 |
| R-HSA-166520 | Signaling by NTRKs | 0.359696 | 0.444 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.362631 | 0.441 |
| R-HSA-204174 | Regulation of pyruvate dehydrogenase (PDH) complex | 0.362631 | 0.441 |
| R-HSA-418360 | Platelet calcium homeostasis | 0.362631 | 0.441 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.362631 | 0.441 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.363746 | 0.439 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.366657 | 0.436 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.368338 | 0.434 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.370789 | 0.431 |
| R-HSA-2424491 | DAP12 signaling | 0.370789 | 0.431 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.370789 | 0.431 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.370789 | 0.431 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.370789 | 0.431 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.372917 | 0.428 |
| R-HSA-8951664 | Neddylation | 0.374873 | 0.426 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.377483 | 0.423 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.378844 | 0.422 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.378844 | 0.422 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.378844 | 0.422 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.378844 | 0.422 |
| R-HSA-1989781 | PPARA activates gene expression | 0.384002 | 0.416 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.386574 | 0.413 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.386574 | 0.413 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.386796 | 0.413 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.386796 | 0.413 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.390911 | 0.408 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.391097 | 0.408 |
| R-HSA-162906 | HIV Infection | 0.392237 | 0.406 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.394359 | 0.404 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.394647 | 0.404 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.394647 | 0.404 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.394647 | 0.404 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.394647 | 0.404 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.394647 | 0.404 |
| R-HSA-9930044 | Nuclear RNA decay | 0.394647 | 0.404 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.394647 | 0.404 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.394647 | 0.404 |
| R-HSA-354192 | Integrin signaling | 0.394647 | 0.404 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.394647 | 0.404 |
| R-HSA-877300 | Interferon gamma signaling | 0.397802 | 0.400 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 0.400100 | 0.398 |
| R-HSA-390522 | Striated Muscle Contraction | 0.402398 | 0.395 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.402398 | 0.395 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.402398 | 0.395 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.402398 | 0.395 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.402398 | 0.395 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 0.402398 | 0.395 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.402398 | 0.395 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 0.402398 | 0.395 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.402398 | 0.395 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.409040 | 0.388 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.410050 | 0.387 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.410050 | 0.387 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.410050 | 0.387 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.410050 | 0.387 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 0.410050 | 0.387 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.410050 | 0.387 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 0.410050 | 0.387 |
| R-HSA-3214847 | HATs acetylate histones | 0.413486 | 0.384 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.414933 | 0.382 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.417604 | 0.379 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.417604 | 0.379 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.417604 | 0.379 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.417916 | 0.379 |
| R-HSA-70171 | Glycolysis | 0.417916 | 0.379 |
| R-HSA-3371511 | HSF1 activation | 0.425062 | 0.372 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.425062 | 0.372 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.425062 | 0.372 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.432425 | 0.364 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.432425 | 0.364 |
| R-HSA-111885 | Opioid Signalling | 0.435462 | 0.361 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.439695 | 0.357 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.439695 | 0.357 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.439695 | 0.357 |
| R-HSA-112316 | Neuronal System | 0.440226 | 0.356 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.444128 | 0.352 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.444128 | 0.352 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.446871 | 0.350 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.446871 | 0.350 |
| R-HSA-201556 | Signaling by ALK | 0.446871 | 0.350 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.446871 | 0.350 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.446871 | 0.350 |
| R-HSA-418346 | Platelet homeostasis | 0.448434 | 0.348 |
| R-HSA-211000 | Gene Silencing by RNA | 0.452721 | 0.344 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.453956 | 0.343 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.453956 | 0.343 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.453956 | 0.343 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.453956 | 0.343 |
| R-HSA-167169 | HIV Transcription Elongation | 0.453956 | 0.343 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.453956 | 0.343 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.453956 | 0.343 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.453956 | 0.343 |
| R-HSA-3371568 | Attenuation phase | 0.453956 | 0.343 |
| R-HSA-9646399 | Aggrephagy | 0.453956 | 0.343 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.456989 | 0.340 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.460951 | 0.336 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.460951 | 0.336 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.460951 | 0.336 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.460951 | 0.336 |
| R-HSA-1640170 | Cell Cycle | 0.462480 | 0.335 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.465468 | 0.332 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.465468 | 0.332 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.467857 | 0.330 |
| R-HSA-9683701 | Translation of Structural Proteins | 0.467857 | 0.330 |
| R-HSA-2559583 | Cellular Senescence | 0.471879 | 0.326 |
| R-HSA-991365 | Activation of GABAB receptors | 0.474675 | 0.324 |
| R-HSA-977444 | GABA B receptor activation | 0.474675 | 0.324 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.474675 | 0.324 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.480232 | 0.319 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.481405 | 0.317 |
| R-HSA-8854214 | TBC/RABGAPs | 0.481405 | 0.317 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 0.481405 | 0.317 |
| R-HSA-166663 | Initial triggering of complement | 0.486319 | 0.313 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.486319 | 0.313 |
| R-HSA-2172127 | DAP12 interactions | 0.488050 | 0.312 |
| R-HSA-375280 | Amine ligand-binding receptors | 0.488050 | 0.312 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.494610 | 0.306 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.494610 | 0.306 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 0.494610 | 0.306 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 0.494610 | 0.306 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.494610 | 0.306 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.501087 | 0.300 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.501087 | 0.300 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.501087 | 0.300 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.501087 | 0.300 |
| R-HSA-9675135 | Diseases of DNA repair | 0.501087 | 0.300 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 0.501087 | 0.300 |
| R-HSA-70326 | Glucose metabolism | 0.502634 | 0.299 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.507481 | 0.295 |
| R-HSA-1483191 | Synthesis of PC | 0.507481 | 0.295 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.513793 | 0.289 |
| R-HSA-9634597 | GPER1 signaling | 0.513793 | 0.289 |
| R-HSA-70263 | Gluconeogenesis | 0.513793 | 0.289 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.513793 | 0.289 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.520025 | 0.284 |
| R-HSA-9766229 | Degradation of CDH1 | 0.520025 | 0.284 |
| R-HSA-72766 | Translation | 0.520985 | 0.283 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.526177 | 0.279 |
| R-HSA-109704 | PI3K Cascade | 0.526177 | 0.279 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.526473 | 0.279 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.532251 | 0.274 |
| R-HSA-912446 | Meiotic recombination | 0.532251 | 0.274 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.532251 | 0.274 |
| R-HSA-977606 | Regulation of Complement cascade | 0.534248 | 0.272 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.537012 | 0.270 |
| R-HSA-72187 | mRNA 3'-end processing | 0.538247 | 0.269 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.538247 | 0.269 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.538247 | 0.269 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.538247 | 0.269 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.538247 | 0.269 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.538247 | 0.269 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.541607 | 0.266 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.544167 | 0.264 |
| R-HSA-1221632 | Meiotic synapsis | 0.544167 | 0.264 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.544167 | 0.264 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.547596 | 0.262 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.549534 | 0.260 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.550011 | 0.260 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.555781 | 0.255 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.555781 | 0.255 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.555781 | 0.255 |
| R-HSA-418597 | G alpha (z) signalling events | 0.555781 | 0.255 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.555781 | 0.255 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.557045 | 0.254 |
| R-HSA-1474165 | Reproduction | 0.560767 | 0.251 |
| R-HSA-75893 | TNF signaling | 0.561477 | 0.251 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.561477 | 0.251 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.561477 | 0.251 |
| R-HSA-5576891 | Cardiac conduction | 0.564467 | 0.248 |
| R-HSA-112399 | IRS-mediated signalling | 0.567100 | 0.246 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.567100 | 0.246 |
| R-HSA-5621480 | Dectin-2 family | 0.567100 | 0.246 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.567100 | 0.246 |
| R-HSA-9909396 | Circadian clock | 0.568145 | 0.246 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.568145 | 0.246 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.572652 | 0.242 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.572652 | 0.242 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.572652 | 0.242 |
| R-HSA-397014 | Muscle contraction | 0.574440 | 0.241 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.578092 | 0.238 |
| R-HSA-186712 | Regulation of beta-cell development | 0.578133 | 0.238 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.583544 | 0.234 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.583544 | 0.234 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.583544 | 0.234 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.583544 | 0.234 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.583544 | 0.234 |
| R-HSA-5362517 | Signaling by Retinoic Acid | 0.583544 | 0.234 |
| R-HSA-68882 | Mitotic Anaphase | 0.586013 | 0.232 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.588875 | 0.230 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.588885 | 0.230 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.588885 | 0.230 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.588885 | 0.230 |
| R-HSA-445717 | Aquaporin-mediated transport | 0.588885 | 0.230 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.588885 | 0.230 |
| R-HSA-450294 | MAP kinase activation | 0.588885 | 0.230 |
| R-HSA-68886 | M Phase | 0.593110 | 0.227 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.593261 | 0.227 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.594159 | 0.226 |
| R-HSA-9707616 | Heme signaling | 0.594159 | 0.226 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.596759 | 0.224 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.599365 | 0.222 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.599365 | 0.222 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.599365 | 0.222 |
| R-HSA-8848021 | Signaling by PTK6 | 0.599365 | 0.222 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.599365 | 0.222 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.599365 | 0.222 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.604505 | 0.219 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.604505 | 0.219 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.609579 | 0.215 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.609579 | 0.215 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.610527 | 0.214 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.613913 | 0.212 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.614060 | 0.212 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.614589 | 0.211 |
| R-HSA-1280218 | Adaptive Immune System | 0.619097 | 0.208 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.619534 | 0.208 |
| R-HSA-166658 | Complement cascade | 0.620617 | 0.207 |
| R-HSA-392499 | Metabolism of proteins | 0.624342 | 0.205 |
| R-HSA-167172 | Transcription of the HIV genome | 0.624416 | 0.205 |
| R-HSA-5218859 | Regulated Necrosis | 0.624416 | 0.205 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.624416 | 0.205 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.624416 | 0.205 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.630506 | 0.200 |
| R-HSA-448424 | Interleukin-17 signaling | 0.633994 | 0.198 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.638692 | 0.195 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.638692 | 0.195 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.638692 | 0.195 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.640194 | 0.194 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.643329 | 0.192 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.643329 | 0.192 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.644788 | 0.191 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.647908 | 0.188 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.647908 | 0.188 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.649682 | 0.187 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.652428 | 0.185 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.652428 | 0.185 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.652428 | 0.185 |
| R-HSA-380287 | Centrosome maturation | 0.656890 | 0.183 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.656890 | 0.183 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 0.656890 | 0.183 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.656890 | 0.183 |
| R-HSA-162587 | HIV Life Cycle | 0.658972 | 0.181 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.661295 | 0.180 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.661295 | 0.180 |
| R-HSA-168249 | Innate Immune System | 0.668932 | 0.175 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.669937 | 0.174 |
| R-HSA-6783783 | Interleukin-10 signaling | 0.669937 | 0.174 |
| R-HSA-5619084 | ABC transporter disorders | 0.669937 | 0.174 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.674175 | 0.171 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.675485 | 0.170 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.678359 | 0.169 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.678359 | 0.169 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.679883 | 0.168 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.682490 | 0.166 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.686568 | 0.163 |
| R-HSA-2262752 | Cellular responses to stress | 0.689507 | 0.161 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.694568 | 0.158 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.694568 | 0.158 |
| R-HSA-388396 | GPCR downstream signalling | 0.697408 | 0.157 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.698491 | 0.156 |
| R-HSA-72306 | tRNA processing | 0.699741 | 0.155 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.702365 | 0.153 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.706189 | 0.151 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.707936 | 0.150 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.707936 | 0.150 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.709964 | 0.149 |
| R-HSA-70268 | Pyruvate metabolism | 0.709964 | 0.149 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.713690 | 0.146 |
| R-HSA-9663891 | Selective autophagy | 0.713690 | 0.146 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.717528 | 0.144 |
| R-HSA-202424 | Downstream TCR signaling | 0.721001 | 0.142 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.724587 | 0.140 |
| R-HSA-449147 | Signaling by Interleukins | 0.727669 | 0.138 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.730414 | 0.136 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.731621 | 0.136 |
| R-HSA-446728 | Cell junction organization | 0.738747 | 0.132 |
| R-HSA-69275 | G2/M Transition | 0.741321 | 0.130 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.746158 | 0.127 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.748434 | 0.126 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.748434 | 0.126 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.748434 | 0.126 |
| R-HSA-983712 | Ion channel transport | 0.748548 | 0.126 |
| R-HSA-5617833 | Cilium Assembly | 0.750919 | 0.124 |
| R-HSA-157579 | Telomere Maintenance | 0.751668 | 0.124 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.751668 | 0.124 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.753270 | 0.123 |
| R-HSA-597592 | Post-translational protein modification | 0.754470 | 0.122 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.754861 | 0.122 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.754861 | 0.122 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.754861 | 0.122 |
| R-HSA-68877 | Mitotic Prometaphase | 0.757916 | 0.120 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.758014 | 0.120 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.761126 | 0.119 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.764198 | 0.117 |
| R-HSA-9609690 | HCMV Early Events | 0.764743 | 0.116 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.764743 | 0.116 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.767231 | 0.115 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.768612 | 0.114 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.773587 | 0.111 |
| R-HSA-9833110 | RSV-host interactions | 0.776098 | 0.110 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.776098 | 0.110 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.776098 | 0.110 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.780029 | 0.108 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.787401 | 0.104 |
| R-HSA-5419276 | Mitochondrial translation termination | 0.790136 | 0.102 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.790136 | 0.102 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.798135 | 0.098 |
| R-HSA-372790 | Signaling by GPCR | 0.799985 | 0.097 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.800734 | 0.097 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.800734 | 0.097 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.808330 | 0.092 |
| R-HSA-418990 | Adherens junctions interactions | 0.811749 | 0.091 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.814382 | 0.089 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.815639 | 0.089 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.815639 | 0.089 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.820357 | 0.086 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.820357 | 0.086 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.820357 | 0.086 |
| R-HSA-68875 | Mitotic Prophase | 0.822670 | 0.085 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.824954 | 0.084 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.824954 | 0.084 |
| R-HSA-73886 | Chromosome Maintenance | 0.824954 | 0.084 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 0.824954 | 0.084 |
| R-HSA-1643685 | Disease | 0.827012 | 0.082 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.827209 | 0.082 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.827209 | 0.082 |
| R-HSA-9717207 | Sensory perception of sweet, bitter, and umami (glutamate) taste | 0.829434 | 0.081 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.829434 | 0.081 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.835942 | 0.078 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.835942 | 0.078 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.835942 | 0.078 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.844090 | 0.074 |
| R-HSA-9843745 | Adipogenesis | 0.850181 | 0.070 |
| R-HSA-9717189 | Sensory perception of taste | 0.850181 | 0.070 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.852112 | 0.070 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.859017 | 0.066 |
| R-HSA-163685 | Integration of energy metabolism | 0.861402 | 0.065 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.863189 | 0.064 |
| R-HSA-199991 | Membrane Trafficking | 0.863228 | 0.064 |
| R-HSA-9609646 | HCMV Infection | 0.863235 | 0.064 |
| R-HSA-421270 | Cell-cell junction organization | 0.864616 | 0.063 |
| R-HSA-5368287 | Mitochondrial translation | 0.864954 | 0.063 |
| R-HSA-6807070 | PTEN Regulation | 0.866695 | 0.062 |
| R-HSA-5688426 | Deubiquitination | 0.870010 | 0.060 |
| R-HSA-1632852 | Macroautophagy | 0.870112 | 0.060 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.876685 | 0.057 |
| R-HSA-416476 | G alpha (q) signalling events | 0.881436 | 0.055 |
| R-HSA-168256 | Immune System | 0.881888 | 0.055 |
| R-HSA-69242 | S Phase | 0.882928 | 0.054 |
| R-HSA-9758941 | Gastrulation | 0.884438 | 0.053 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.888855 | 0.051 |
| R-HSA-9612973 | Autophagy | 0.894485 | 0.048 |
| R-HSA-9610379 | HCMV Late Events | 0.895847 | 0.048 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.901562 | 0.045 |
| R-HSA-74160 | Gene expression (Transcription) | 0.904051 | 0.044 |
| R-HSA-5619102 | SLC transporter disorders | 0.908544 | 0.042 |
| R-HSA-418555 | G alpha (s) signalling events | 0.914302 | 0.039 |
| R-HSA-418594 | G alpha (i) signalling events | 0.914619 | 0.039 |
| R-HSA-212436 | Generic Transcription Pathway | 0.914647 | 0.039 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.916503 | 0.038 |
| R-HSA-611105 | Respiratory electron transport | 0.921762 | 0.035 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.926692 | 0.033 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.934799 | 0.029 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.935388 | 0.029 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.943505 | 0.025 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.947382 | 0.023 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.957934 | 0.019 |
| R-HSA-157118 | Signaling by NOTCH | 0.965594 | 0.015 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.967116 | 0.015 |
| R-HSA-109582 | Hemostasis | 0.979079 | 0.009 |
| R-HSA-1483257 | Phospholipid metabolism | 0.983250 | 0.007 |
| R-HSA-195721 | Signaling by WNT | 0.983896 | 0.007 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.985338 | 0.006 |
| R-HSA-6798695 | Neutrophil degranulation | 0.985668 | 0.006 |
| R-HSA-8957322 | Metabolism of steroids | 0.988552 | 0.005 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.989473 | 0.005 |
| R-HSA-1474244 | Extracellular matrix organization | 0.989558 | 0.005 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.995261 | 0.002 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.995504 | 0.002 |
| R-HSA-382551 | Transport of small molecules | 0.996689 | 0.001 |
| R-HSA-500792 | GPCR ligand binding | 0.999662 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999948 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999997 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
FAM20C |
0.893 | 0.733 | 2 | 0.916 |
COT |
0.874 | 0.102 | 2 | 0.664 |
CLK3 |
0.867 | 0.193 | 1 | 0.840 |
CDC7 |
0.867 | 0.057 | 1 | 0.878 |
PIM3 |
0.862 | 0.071 | -3 | 0.862 |
CAMK2G |
0.862 | 0.088 | 2 | 0.700 |
PRPK |
0.862 | -0.032 | -1 | 0.861 |
MOS |
0.862 | 0.064 | 1 | 0.885 |
CAMK1B |
0.862 | 0.068 | -3 | 0.885 |
PRKD1 |
0.862 | 0.116 | -3 | 0.839 |
CAMK2B |
0.861 | 0.256 | 2 | 0.733 |
NDR2 |
0.860 | 0.039 | -3 | 0.878 |
TSSK2 |
0.859 | 0.147 | -5 | 0.882 |
CAMK2D |
0.858 | 0.158 | -3 | 0.874 |
SKMLCK |
0.857 | 0.119 | -2 | 0.869 |
MARK4 |
0.857 | 0.090 | 4 | 0.864 |
DSTYK |
0.857 | 0.038 | 2 | 0.688 |
PDHK4 |
0.856 | -0.052 | 1 | 0.838 |
ATR |
0.856 | 0.056 | 1 | 0.868 |
RSK2 |
0.856 | 0.073 | -3 | 0.793 |
PRKD2 |
0.855 | 0.095 | -3 | 0.803 |
TSSK1 |
0.855 | 0.118 | -3 | 0.904 |
RAF1 |
0.854 | -0.097 | 1 | 0.834 |
BMPR2 |
0.854 | -0.057 | -2 | 0.907 |
PIM1 |
0.854 | 0.105 | -3 | 0.815 |
WNK1 |
0.853 | 0.021 | -2 | 0.894 |
IKKB |
0.853 | -0.062 | -2 | 0.767 |
NUAK2 |
0.853 | 0.031 | -3 | 0.876 |
AMPKA1 |
0.853 | 0.052 | -3 | 0.889 |
ULK2 |
0.852 | -0.161 | 2 | 0.585 |
GCN2 |
0.852 | -0.186 | 2 | 0.585 |
CDKL1 |
0.852 | 0.016 | -3 | 0.812 |
PKN3 |
0.852 | 0.003 | -3 | 0.850 |
TBK1 |
0.851 | -0.100 | 1 | 0.717 |
MAPKAPK2 |
0.851 | 0.107 | -3 | 0.760 |
GRK1 |
0.851 | 0.093 | -2 | 0.787 |
LATS2 |
0.851 | 0.035 | -5 | 0.740 |
NIK |
0.850 | -0.026 | -3 | 0.909 |
MTOR |
0.850 | -0.122 | 1 | 0.762 |
NDR1 |
0.850 | -0.004 | -3 | 0.868 |
P90RSK |
0.850 | 0.032 | -3 | 0.786 |
DAPK2 |
0.850 | 0.020 | -3 | 0.892 |
CAMLCK |
0.850 | 0.019 | -2 | 0.875 |
ERK5 |
0.850 | -0.005 | 1 | 0.802 |
NLK |
0.849 | -0.084 | 1 | 0.794 |
CAMK2A |
0.849 | 0.131 | 2 | 0.683 |
PDHK1 |
0.849 | -0.162 | 1 | 0.827 |
CDKL5 |
0.848 | 0.029 | -3 | 0.800 |
ATM |
0.848 | 0.130 | 1 | 0.828 |
MAPKAPK3 |
0.848 | 0.033 | -3 | 0.807 |
MST4 |
0.848 | -0.003 | 2 | 0.617 |
GRK6 |
0.848 | 0.024 | 1 | 0.865 |
GRK5 |
0.847 | -0.091 | -3 | 0.885 |
PKCD |
0.847 | 0.010 | 2 | 0.577 |
HUNK |
0.846 | -0.106 | 2 | 0.595 |
RSK3 |
0.846 | 0.014 | -3 | 0.780 |
TGFBR2 |
0.846 | -0.055 | -2 | 0.811 |
AMPKA2 |
0.846 | 0.043 | -3 | 0.858 |
LATS1 |
0.845 | 0.176 | -3 | 0.887 |
RIPK3 |
0.845 | -0.096 | 3 | 0.754 |
PKN2 |
0.845 | -0.033 | -3 | 0.870 |
PKACG |
0.845 | 0.029 | -2 | 0.775 |
IKKE |
0.845 | -0.134 | 1 | 0.706 |
BCKDK |
0.844 | -0.083 | -1 | 0.807 |
IKKA |
0.844 | -0.011 | -2 | 0.750 |
BMPR1B |
0.844 | 0.142 | 1 | 0.829 |
NIM1 |
0.844 | -0.033 | 3 | 0.798 |
TGFBR1 |
0.844 | 0.109 | -2 | 0.825 |
CHAK2 |
0.844 | -0.081 | -1 | 0.854 |
SRPK1 |
0.844 | 0.060 | -3 | 0.758 |
P70S6KB |
0.843 | 0.008 | -3 | 0.826 |
NEK6 |
0.843 | -0.115 | -2 | 0.873 |
WNK3 |
0.843 | -0.175 | 1 | 0.813 |
ICK |
0.843 | 0.003 | -3 | 0.851 |
MLK1 |
0.842 | -0.149 | 2 | 0.592 |
HIPK4 |
0.842 | -0.014 | 1 | 0.753 |
NEK7 |
0.842 | -0.196 | -3 | 0.865 |
ULK1 |
0.841 | -0.187 | -3 | 0.824 |
MNK2 |
0.841 | 0.039 | -2 | 0.820 |
ALK4 |
0.841 | 0.025 | -2 | 0.855 |
MASTL |
0.840 | -0.211 | -2 | 0.841 |
PRKD3 |
0.840 | 0.046 | -3 | 0.767 |
CAMK4 |
0.840 | -0.034 | -3 | 0.868 |
MARK2 |
0.840 | 0.075 | 4 | 0.779 |
GRK4 |
0.839 | -0.080 | -2 | 0.823 |
QSK |
0.839 | 0.034 | 4 | 0.842 |
ALK2 |
0.839 | 0.160 | -2 | 0.831 |
RSK4 |
0.839 | 0.065 | -3 | 0.767 |
MELK |
0.839 | -0.009 | -3 | 0.840 |
RIPK1 |
0.839 | -0.112 | 1 | 0.811 |
KIS |
0.838 | -0.021 | 1 | 0.654 |
AURC |
0.838 | 0.039 | -2 | 0.686 |
DNAPK |
0.838 | 0.155 | 1 | 0.731 |
NUAK1 |
0.838 | -0.002 | -3 | 0.828 |
MARK3 |
0.838 | 0.060 | 4 | 0.805 |
QIK |
0.838 | -0.028 | -3 | 0.875 |
PAK1 |
0.838 | -0.015 | -2 | 0.798 |
SIK |
0.838 | 0.028 | -3 | 0.804 |
SRPK2 |
0.837 | 0.051 | -3 | 0.687 |
MSK2 |
0.837 | -0.002 | -3 | 0.761 |
IRE2 |
0.837 | -0.063 | 2 | 0.553 |
MNK1 |
0.837 | 0.039 | -2 | 0.831 |
CHK1 |
0.836 | 0.068 | -3 | 0.858 |
ANKRD3 |
0.836 | -0.170 | 1 | 0.851 |
SSTK |
0.836 | 0.080 | 4 | 0.841 |
DLK |
0.836 | -0.169 | 1 | 0.835 |
IRE1 |
0.836 | -0.121 | 1 | 0.794 |
PKR |
0.836 | -0.041 | 1 | 0.843 |
BRSK1 |
0.835 | 0.005 | -3 | 0.826 |
PAK3 |
0.835 | -0.054 | -2 | 0.802 |
MSK1 |
0.835 | 0.044 | -3 | 0.765 |
MARK1 |
0.835 | 0.057 | 4 | 0.825 |
NEK9 |
0.834 | -0.224 | 2 | 0.590 |
TTBK2 |
0.834 | -0.196 | 2 | 0.517 |
MLK2 |
0.834 | -0.169 | 2 | 0.585 |
PKCB |
0.833 | -0.032 | 2 | 0.515 |
PKCA |
0.833 | -0.035 | 2 | 0.518 |
MLK3 |
0.833 | -0.098 | 2 | 0.537 |
PKACB |
0.833 | 0.064 | -2 | 0.703 |
CDK8 |
0.833 | -0.042 | 1 | 0.621 |
MYLK4 |
0.833 | 0.018 | -2 | 0.787 |
PKCG |
0.833 | -0.049 | 2 | 0.527 |
BRSK2 |
0.833 | -0.037 | -3 | 0.858 |
PLK1 |
0.832 | -0.082 | -2 | 0.829 |
PLK3 |
0.832 | -0.011 | 2 | 0.656 |
ACVR2A |
0.832 | 0.026 | -2 | 0.804 |
SRPK3 |
0.832 | 0.029 | -3 | 0.734 |
PKG2 |
0.832 | 0.030 | -2 | 0.713 |
AURB |
0.831 | 0.015 | -2 | 0.682 |
PIM2 |
0.831 | 0.047 | -3 | 0.771 |
VRK2 |
0.831 | -0.209 | 1 | 0.871 |
CLK2 |
0.831 | 0.118 | -3 | 0.774 |
BMPR1A |
0.831 | 0.135 | 1 | 0.819 |
MEK1 |
0.831 | -0.162 | 2 | 0.632 |
SMG1 |
0.831 | 0.004 | 1 | 0.823 |
ACVR2B |
0.831 | 0.029 | -2 | 0.811 |
DCAMKL1 |
0.831 | 0.013 | -3 | 0.826 |
CLK4 |
0.830 | 0.028 | -3 | 0.794 |
GRK7 |
0.830 | 0.021 | 1 | 0.793 |
PAK2 |
0.830 | -0.061 | -2 | 0.784 |
DYRK2 |
0.829 | -0.014 | 1 | 0.655 |
CAMK1G |
0.829 | -0.011 | -3 | 0.796 |
PKCH |
0.829 | -0.067 | 2 | 0.516 |
PHKG1 |
0.829 | -0.091 | -3 | 0.870 |
PRKX |
0.829 | 0.094 | -3 | 0.724 |
CAMK1D |
0.828 | 0.075 | -3 | 0.729 |
SGK3 |
0.828 | 0.003 | -3 | 0.789 |
PKCZ |
0.827 | -0.081 | 2 | 0.542 |
BRAF |
0.827 | -0.020 | -4 | 0.879 |
PAK6 |
0.826 | -0.009 | -2 | 0.730 |
DCAMKL2 |
0.826 | -0.011 | -3 | 0.848 |
CLK1 |
0.826 | 0.023 | -3 | 0.773 |
AURA |
0.826 | 0.012 | -2 | 0.647 |
MLK4 |
0.826 | -0.132 | 2 | 0.527 |
NEK2 |
0.826 | -0.168 | 2 | 0.556 |
SNRK |
0.826 | -0.162 | 2 | 0.523 |
CDK7 |
0.825 | -0.060 | 1 | 0.626 |
CDK19 |
0.825 | -0.048 | 1 | 0.580 |
JNK2 |
0.825 | -0.009 | 1 | 0.564 |
CDK5 |
0.825 | -0.021 | 1 | 0.651 |
P38A |
0.824 | -0.023 | 1 | 0.664 |
TLK2 |
0.824 | -0.104 | 1 | 0.807 |
AKT2 |
0.824 | 0.015 | -3 | 0.714 |
PLK4 |
0.823 | -0.137 | 2 | 0.499 |
CHAK1 |
0.823 | -0.188 | 2 | 0.526 |
JNK3 |
0.823 | -0.031 | 1 | 0.606 |
MAPKAPK5 |
0.822 | -0.064 | -3 | 0.740 |
CDK1 |
0.822 | -0.022 | 1 | 0.584 |
YSK4 |
0.822 | -0.200 | 1 | 0.751 |
WNK4 |
0.822 | -0.101 | -2 | 0.888 |
SMMLCK |
0.821 | -0.010 | -3 | 0.841 |
P38B |
0.821 | -0.009 | 1 | 0.600 |
DRAK1 |
0.821 | -0.117 | 1 | 0.754 |
PASK |
0.821 | 0.015 | -3 | 0.881 |
IRAK4 |
0.821 | -0.118 | 1 | 0.811 |
CK1E |
0.821 | 0.002 | -3 | 0.621 |
CDK13 |
0.820 | -0.062 | 1 | 0.596 |
PERK |
0.820 | -0.171 | -2 | 0.848 |
PKACA |
0.819 | 0.042 | -2 | 0.656 |
PHKG2 |
0.819 | -0.056 | -3 | 0.842 |
GRK2 |
0.819 | -0.075 | -2 | 0.714 |
PRP4 |
0.819 | -0.030 | -3 | 0.754 |
DAPK3 |
0.818 | 0.055 | -3 | 0.837 |
HIPK1 |
0.818 | -0.016 | 1 | 0.669 |
NEK5 |
0.818 | -0.150 | 1 | 0.838 |
PKCT |
0.817 | -0.063 | 2 | 0.521 |
HRI |
0.817 | -0.201 | -2 | 0.862 |
TLK1 |
0.817 | -0.112 | -2 | 0.830 |
MEK5 |
0.817 | -0.277 | 2 | 0.607 |
CDK18 |
0.817 | -0.043 | 1 | 0.555 |
MEKK3 |
0.817 | -0.189 | 1 | 0.789 |
CDK2 |
0.816 | -0.068 | 1 | 0.678 |
MEKK2 |
0.816 | -0.167 | 2 | 0.582 |
MEKK1 |
0.816 | -0.212 | 1 | 0.812 |
AKT1 |
0.816 | 0.013 | -3 | 0.740 |
MPSK1 |
0.815 | -0.011 | 1 | 0.758 |
ZAK |
0.815 | -0.190 | 1 | 0.778 |
DYRK4 |
0.815 | -0.000 | 1 | 0.573 |
P70S6K |
0.815 | -0.039 | -3 | 0.730 |
MST3 |
0.815 | -0.097 | 2 | 0.576 |
DYRK1A |
0.815 | -0.040 | 1 | 0.693 |
ERK2 |
0.814 | -0.087 | 1 | 0.624 |
GAK |
0.814 | 0.002 | 1 | 0.836 |
IRAK1 |
0.814 | -0.142 | -1 | 0.762 |
ERK1 |
0.814 | -0.061 | 1 | 0.578 |
HIPK2 |
0.814 | -0.015 | 1 | 0.552 |
CK1D |
0.813 | 0.017 | -3 | 0.575 |
P38G |
0.813 | -0.044 | 1 | 0.492 |
CDK12 |
0.813 | -0.065 | 1 | 0.567 |
CDK17 |
0.813 | -0.054 | 1 | 0.502 |
PINK1 |
0.812 | -0.193 | 1 | 0.792 |
TAO3 |
0.812 | -0.090 | 1 | 0.777 |
TTBK1 |
0.812 | -0.174 | 2 | 0.472 |
PKCI |
0.812 | -0.074 | 2 | 0.518 |
HIPK3 |
0.812 | -0.055 | 1 | 0.663 |
CDK9 |
0.812 | -0.087 | 1 | 0.604 |
CK2A2 |
0.811 | 0.072 | 1 | 0.712 |
DYRK1B |
0.811 | -0.028 | 1 | 0.602 |
PKCE |
0.811 | -0.025 | 2 | 0.511 |
EEF2K |
0.810 | -0.045 | 3 | 0.860 |
LKB1 |
0.810 | -0.094 | -3 | 0.873 |
CAMKK1 |
0.810 | -0.155 | -2 | 0.785 |
TAO2 |
0.809 | -0.113 | 2 | 0.619 |
CDK3 |
0.809 | -0.010 | 1 | 0.522 |
CK1G1 |
0.809 | -0.041 | -3 | 0.608 |
DAPK1 |
0.809 | 0.017 | -3 | 0.816 |
CK1A2 |
0.809 | -0.003 | -3 | 0.574 |
DYRK3 |
0.809 | -0.020 | 1 | 0.671 |
CAMK1A |
0.808 | 0.026 | -3 | 0.681 |
CDK14 |
0.808 | -0.057 | 1 | 0.597 |
CAMKK2 |
0.808 | -0.131 | -2 | 0.783 |
PLK2 |
0.807 | -0.003 | -3 | 0.782 |
P38D |
0.807 | -0.028 | 1 | 0.519 |
MRCKA |
0.806 | 0.018 | -3 | 0.794 |
NEK8 |
0.806 | -0.228 | 2 | 0.585 |
ERK7 |
0.806 | -0.077 | 2 | 0.344 |
CDK10 |
0.805 | -0.028 | 1 | 0.581 |
ROCK2 |
0.805 | 0.039 | -3 | 0.820 |
PKN1 |
0.805 | -0.052 | -3 | 0.755 |
PDK1 |
0.805 | -0.133 | 1 | 0.779 |
PDHK3_TYR |
0.805 | 0.148 | 4 | 0.900 |
GRK3 |
0.805 | -0.062 | -2 | 0.661 |
CDK16 |
0.804 | -0.035 | 1 | 0.522 |
MRCKB |
0.804 | 0.014 | -3 | 0.771 |
BUB1 |
0.804 | 0.066 | -5 | 0.842 |
CHK2 |
0.804 | -0.015 | -3 | 0.663 |
PAK5 |
0.804 | -0.060 | -2 | 0.656 |
TNIK |
0.803 | -0.051 | 3 | 0.880 |
NEK11 |
0.803 | -0.256 | 1 | 0.769 |
SGK1 |
0.803 | 0.022 | -3 | 0.627 |
MEKK6 |
0.803 | -0.165 | 1 | 0.796 |
GSK3B |
0.803 | -0.068 | 4 | 0.386 |
GCK |
0.803 | -0.089 | 1 | 0.771 |
NEK4 |
0.803 | -0.186 | 1 | 0.784 |
MAP3K15 |
0.803 | -0.150 | 1 | 0.753 |
HGK |
0.802 | -0.093 | 3 | 0.879 |
MST2 |
0.802 | -0.144 | 1 | 0.799 |
PAK4 |
0.802 | -0.054 | -2 | 0.664 |
NEK1 |
0.802 | -0.135 | 1 | 0.805 |
LRRK2 |
0.801 | -0.175 | 2 | 0.613 |
STK33 |
0.801 | -0.145 | 2 | 0.483 |
GSK3A |
0.801 | -0.045 | 4 | 0.396 |
MINK |
0.801 | -0.101 | 1 | 0.771 |
DMPK1 |
0.801 | 0.067 | -3 | 0.800 |
PBK |
0.801 | -0.009 | 1 | 0.763 |
SBK |
0.800 | 0.034 | -3 | 0.594 |
CK2A1 |
0.800 | 0.047 | 1 | 0.684 |
VRK1 |
0.800 | -0.180 | 2 | 0.611 |
AKT3 |
0.800 | 0.008 | -3 | 0.645 |
TAK1 |
0.800 | -0.166 | 1 | 0.818 |
MAK |
0.799 | 0.042 | -2 | 0.757 |
HPK1 |
0.797 | -0.092 | 1 | 0.747 |
LOK |
0.797 | -0.128 | -2 | 0.808 |
JNK1 |
0.796 | -0.056 | 1 | 0.556 |
KHS1 |
0.796 | -0.054 | 1 | 0.752 |
TESK1_TYR |
0.796 | -0.022 | 3 | 0.895 |
PDHK4_TYR |
0.796 | 0.058 | 2 | 0.689 |
KHS2 |
0.795 | -0.022 | 1 | 0.759 |
MST1 |
0.795 | -0.157 | 1 | 0.777 |
MOK |
0.795 | 0.011 | 1 | 0.696 |
MAP2K4_TYR |
0.795 | -0.019 | -1 | 0.881 |
MAP2K6_TYR |
0.794 | 0.037 | -1 | 0.881 |
CDK6 |
0.794 | -0.062 | 1 | 0.573 |
CDK4 |
0.794 | -0.058 | 1 | 0.555 |
EPHA6 |
0.793 | 0.075 | -1 | 0.853 |
MEK2 |
0.792 | -0.263 | 2 | 0.592 |
MAP2K7_TYR |
0.792 | -0.143 | 2 | 0.666 |
PKMYT1_TYR |
0.792 | -0.080 | 3 | 0.864 |
YSK1 |
0.792 | -0.154 | 2 | 0.559 |
PKG1 |
0.792 | -0.019 | -2 | 0.639 |
YANK3 |
0.791 | -0.051 | 2 | 0.356 |
ALPHAK3 |
0.791 | 0.061 | -1 | 0.771 |
PDHK1_TYR |
0.791 | -0.011 | -1 | 0.893 |
CRIK |
0.790 | 0.025 | -3 | 0.729 |
ROCK1 |
0.790 | 0.007 | -3 | 0.788 |
RIPK2 |
0.790 | -0.253 | 1 | 0.724 |
SLK |
0.790 | -0.137 | -2 | 0.741 |
BMPR2_TYR |
0.789 | 0.002 | -1 | 0.863 |
EPHB4 |
0.789 | 0.043 | -1 | 0.840 |
LIMK2_TYR |
0.789 | -0.038 | -3 | 0.914 |
TTK |
0.788 | -0.076 | -2 | 0.828 |
BIKE |
0.788 | 0.022 | 1 | 0.712 |
PINK1_TYR |
0.788 | -0.162 | 1 | 0.832 |
NEK3 |
0.786 | -0.189 | 1 | 0.751 |
EPHA4 |
0.786 | 0.077 | 2 | 0.663 |
HASPIN |
0.785 | -0.025 | -1 | 0.711 |
RET |
0.785 | -0.075 | 1 | 0.806 |
TYRO3 |
0.785 | -0.071 | 3 | 0.817 |
DDR1 |
0.784 | -0.024 | 4 | 0.850 |
FER |
0.783 | 0.004 | 1 | 0.923 |
ROS1 |
0.783 | -0.105 | 3 | 0.790 |
SRMS |
0.783 | 0.068 | 1 | 0.898 |
TYK2 |
0.782 | -0.141 | 1 | 0.807 |
LIMK1_TYR |
0.782 | -0.165 | 2 | 0.643 |
EPHB2 |
0.782 | 0.070 | -1 | 0.821 |
EPHB3 |
0.782 | 0.042 | -1 | 0.821 |
YES1 |
0.782 | 0.015 | -1 | 0.854 |
ABL2 |
0.782 | 0.022 | -1 | 0.809 |
EPHB1 |
0.781 | 0.014 | 1 | 0.892 |
MST1R |
0.781 | -0.138 | 3 | 0.822 |
ASK1 |
0.780 | -0.172 | 1 | 0.740 |
JAK2 |
0.780 | -0.116 | 1 | 0.802 |
OSR1 |
0.780 | -0.158 | 2 | 0.561 |
FGR |
0.780 | -0.037 | 1 | 0.883 |
TXK |
0.780 | 0.036 | 1 | 0.865 |
MYO3B |
0.779 | -0.130 | 2 | 0.575 |
INSRR |
0.779 | 0.004 | 3 | 0.759 |
HCK |
0.778 | -0.005 | -1 | 0.822 |
TNK2 |
0.777 | -0.045 | 3 | 0.765 |
ABL1 |
0.777 | -0.019 | -1 | 0.805 |
CSF1R |
0.777 | -0.108 | 3 | 0.798 |
ITK |
0.776 | -0.030 | -1 | 0.794 |
FGFR2 |
0.775 | -0.046 | 3 | 0.799 |
JAK3 |
0.775 | -0.107 | 1 | 0.784 |
TNNI3K_TYR |
0.775 | -0.051 | 1 | 0.840 |
EPHA7 |
0.775 | 0.033 | 2 | 0.653 |
BLK |
0.775 | 0.041 | -1 | 0.831 |
LCK |
0.775 | 0.008 | -1 | 0.824 |
TAO1 |
0.774 | -0.152 | 1 | 0.700 |
AXL |
0.774 | -0.061 | 3 | 0.783 |
MERTK |
0.774 | -0.036 | 3 | 0.778 |
MYO3A |
0.773 | -0.161 | 1 | 0.763 |
PDGFRB |
0.773 | -0.124 | 3 | 0.815 |
TEK |
0.773 | -0.082 | 3 | 0.743 |
AAK1 |
0.772 | 0.053 | 1 | 0.604 |
EPHA3 |
0.772 | -0.024 | 2 | 0.639 |
FGFR1 |
0.772 | -0.091 | 3 | 0.780 |
TNK1 |
0.772 | -0.097 | 3 | 0.789 |
BMX |
0.771 | -0.017 | -1 | 0.706 |
FLT3 |
0.771 | -0.112 | 3 | 0.808 |
FYN |
0.770 | 0.048 | -1 | 0.800 |
EPHA5 |
0.770 | 0.073 | 2 | 0.673 |
CK1A |
0.770 | -0.040 | -3 | 0.485 |
KIT |
0.770 | -0.102 | 3 | 0.797 |
LTK |
0.769 | -0.062 | 3 | 0.754 |
TEC |
0.769 | -0.049 | -1 | 0.737 |
DDR2 |
0.768 | 0.050 | 3 | 0.749 |
BTK |
0.768 | -0.099 | -1 | 0.758 |
ALK |
0.768 | -0.101 | 3 | 0.737 |
PTK2B |
0.768 | -0.013 | -1 | 0.785 |
KDR |
0.767 | -0.137 | 3 | 0.758 |
EPHA1 |
0.767 | -0.054 | 3 | 0.764 |
LYN |
0.766 | -0.002 | 3 | 0.727 |
PDGFRA |
0.765 | -0.200 | 3 | 0.815 |
NTRK1 |
0.765 | -0.109 | -1 | 0.815 |
MET |
0.765 | -0.114 | 3 | 0.788 |
FRK |
0.764 | -0.080 | -1 | 0.832 |
INSR |
0.764 | -0.078 | 3 | 0.738 |
JAK1 |
0.763 | -0.151 | 1 | 0.732 |
FGFR3 |
0.763 | -0.086 | 3 | 0.769 |
ERBB2 |
0.763 | -0.112 | 1 | 0.779 |
PTK6 |
0.763 | -0.184 | -1 | 0.735 |
EPHA8 |
0.762 | -0.010 | -1 | 0.797 |
STLK3 |
0.762 | -0.257 | 1 | 0.741 |
PTK2 |
0.762 | 0.024 | -1 | 0.775 |
NEK10_TYR |
0.761 | -0.181 | 1 | 0.636 |
EGFR |
0.761 | -0.006 | 1 | 0.703 |
WEE1_TYR |
0.760 | -0.143 | -1 | 0.743 |
FLT1 |
0.759 | -0.128 | -1 | 0.833 |
FLT4 |
0.758 | -0.161 | 3 | 0.754 |
NTRK2 |
0.758 | -0.179 | 3 | 0.767 |
SRC |
0.758 | -0.039 | -1 | 0.807 |
YANK2 |
0.757 | -0.071 | 2 | 0.379 |
EPHA2 |
0.755 | 0.001 | -1 | 0.761 |
NTRK3 |
0.755 | -0.121 | -1 | 0.765 |
CSK |
0.755 | -0.100 | 2 | 0.641 |
SYK |
0.754 | 0.026 | -1 | 0.758 |
MATK |
0.754 | -0.119 | -1 | 0.739 |
CK1G3 |
0.753 | -0.029 | -3 | 0.437 |
FGFR4 |
0.752 | -0.051 | -1 | 0.775 |
IGF1R |
0.749 | -0.080 | 3 | 0.675 |
ERBB4 |
0.747 | -0.015 | 1 | 0.731 |
MUSK |
0.739 | -0.175 | 1 | 0.684 |
FES |
0.737 | -0.120 | -1 | 0.693 |
CK1G2 |
0.730 | -0.048 | -3 | 0.531 |
ZAP70 |
0.723 | -0.064 | -1 | 0.674 |